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Sample records for atom ssa dan

  1. Global transcript and phenotypic analysis of yeast cells expressing Ssa1, Ssa2, Ssa3 or Ssa4 as sole source of cytosolic Hsp70-Ssa chaperone activity.

    PubMed

    Hasin, Naushaba; Cusack, Sarah A; Ali, Shahin S; Fitzpatrick, David A; Jones, Gary W

    2014-03-14

    Cytosolic Hsp70 is a ubiquitous molecular chaperone that is involved in responding to a variety of cellular stresses. A major function of Hsp70 is to prevent the aggregation of denatured proteins by binding to exposed hydrophobic regions and preventing the accumulation of amorphous aggregates. To gain further insight into the functional redundancy and specialisation of the highly homologous yeast Hsp70-Ssa family we expressed each of the individual Ssa proteins as the sole source of Hsp70 in the cell and assessed phenotypic differences in prion propagation and stress resistance. Additionally we also analysed the global gene expression patterns in yeast strains expressing individual Ssa proteins, using microarray and RT-qPCR analysis. We confirm and extend previous studies demonstrating that cells expressing different Hsp70-Ssa isoforms vary in their ability to propagate the yeast [PSI+] prion, with Ssa3 being the most proficient. Of the four Ssa family members the heat inducible isoforms are more proficient in acquiring thermotolerance and we show a greater requirement than was previously thought, for cellular processes in addition to the traditional Hsp104 protein disaggregase machinery, in acquiring such thermotolerance. Cells expressing different Hsp70-Ssa isoforms also display differences in phenotypic response to exposure to cell wall damaging and oxidative stress agents, again with the heat inducible isoforms providing better protection than constitutive isoforms. We assessed global transcriptome profiles for cells expressing individual Hsp70-Ssa isoforms as the sole source of cytosolic Hsp70, and identified a significant difference in cellular gene expression between these strains. Differences in gene expression profiles provide a rationale for some phenotypic differences we observed in this study. We also demonstrate a high degree of correlation between microarray data and RT-qPCR analysis for a selection of genes. The Hsp70-Ssa family provide both

  2. NASA SSA for Robotic Missions

    NASA Technical Reports Server (NTRS)

    Newman, Lauri K.

    2009-01-01

    This viewgraph presentation reviews NASA's Space Situational Awareness (SSA) activities as preparation for robotic missions and Goddard's role in this work. The presentation includes the preparations that Goddard Space Flight Center (GSFC) has made to provide consolidated space systems protection indluding consolidating GSFC support for Orbit Debris analysis, conjunction assessment and collision avoidance, commercial and foreign support, and protection of GSFC managed missions.

  3. AFSPC A5CS SSA Activities

    NASA Astrophysics Data System (ADS)

    Thacher, H.

    2011-09-01

    With the signing of the National Space Policy in June of 2010 and the National Security Space Strategy in January of this year, the Department of Defense and the Air Force have clear direction to preserve vital national security capabilities in space. The ever-growing population of resident space objects necessitates improved Space Situational Awareness (SSA) to ensure safety of flight and enable defensive actions when necessary. The Air Force, through Air Force Space Command, has placed a particular emphasis on increasing National SSA capabilities in the Deep Space environment by fielding technologically advanced systems, seeking partnership opportunities, and identifying areas where data exploitation and technology advancements are needed. This presentation will discuss space and groundbased optical SSA sensor capabilities recently fielded to close key SSA capability gaps, describe how these sensors are being used to develop new tactics, techniques and procedures for conducting SSA and discuss activities underway to further exploit these new capabilities. The presentation will also discuss areas ripe for partnership with industry and other government agencies to tap into non-traditional SSA data sources to improve SSA capabilities while reducing overall cost. This could include opportunities to exploit inherent capabilities of existing systems or to enhance SSA capabilities through system modification. Finally, the presentation will identify where Air Force Space Command sees potential for capability advancement such as self aware SSA technologies and potential exploitation of space-based infrared collections. The presentation will close by challenging the audience to help meet National SSA objectives by developing new, innovative capabilities and techniques for SSA.

  4. An Improvement on SSA Congruence for Geometry and Trigonometry.

    ERIC Educational Resources Information Center

    Yeshurun, Shraga; Kay, David C.

    1983-01-01

    Three ideas are explored: (1) an improvement of the SSA congruence theorem for trigonometry; (2) a discussion of the failure of SSA in spherical geometry; and (3) an extension of SSA to spherical geometry and hyperbolic geometry. (MNS)

  5. An Improvement on SSA Congruence for Geometry and Trigonometry.

    ERIC Educational Resources Information Center

    Yeshurun, Shraga; Kay, David C.

    1983-01-01

    Three ideas are explored: (1) an improvement of the SSA congruence theorem for trigonometry; (2) a discussion of the failure of SSA in spherical geometry; and (3) an extension of SSA to spherical geometry and hyperbolic geometry. (MNS)

  6. The Case for GEO Hosted SSA Payloads

    NASA Astrophysics Data System (ADS)

    Welsch, C.; Armand, B.; Repp, M.; Robinson, A.

    2014-09-01

    Space situational awareness (SSA) in the geosynchronous earth orbit (GEO) belt presents unique challenges, and given the national importance and high value of GEO satellites, is increasingly critical as space becomes more congested and contested. Space situational awareness capabilities can serve as an effective deterrent against potential adversaries if they provide accurate, timely, and persistent information and are resilient to the threat environment. This paper will demonstrate how simple optical SSA payloads hosted on GEO commercial and government satellites can complement the SSA mission and data provided by Space-Based Space Surveillance (SBSS) and the Geosynchronous Space Situational Awareness Program (GSSAP). GSSAP is built by Orbital Sciences Corporation and launched on July 28, 2014. Analysis performed for this paper will show how GEO hosted SSA payloads, working in combination with SBSS and GSSAP, can increase persistence and timely coverage of high value assets in the GEO belt. The potential to further increase GEO object identification and tracking accuracy by integrating SSA data from multiple sources across different viewing angles including GEO hosted SSA sources will be addressed. Hosting SSA payloads on GEO platforms also increases SSA mission architecture resiliency as the sensors are by distributed across multiple platforms including commercial platforms. This distributed architecture presents a challenging target for an adversary to attempt to degrade or disable. We will present a viable concept of operations to show how data from hosted SSA sensors could be integrated with SBSS and GSSAP data to present a comprehensive and more accurate data set to users. Lastly, we will present an acquisition approach using commercial practices and building on lessons learned from the Commercially Hosted Infra Red Payload CHIRP to demonstrate the affordability of GEO hosted SSA payloads.

  7. 20 CFR 422.710 - Procedures SSA will follow.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Procedures SSA will follow. 422.710 Section 422.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ORGANIZATION AND PROCEDURES Use of SSA Telephone Lines § 422.710 Procedures SSA will follow. SSA component(s) that plan to listen-in to or record...

  8. 20 CFR 422.710 - Procedures SSA will follow.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Procedures SSA will follow. 422.710 Section 422.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ORGANIZATION AND PROCEDURES Use of SSA Telephone Lines § 422.710 Procedures SSA will follow. SSA component(s) that plan to listen-in to or record...

  9. 20 CFR 422.710 - Procedures SSA will follow.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Procedures SSA will follow. 422.710 Section 422.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ORGANIZATION AND PROCEDURES Use of SSA Telephone Lines § 422.710 Procedures SSA will follow. SSA component(s) that plan to listen-in to or record...

  10. 20 CFR 422.710 - Procedures SSA will follow.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Procedures SSA will follow. 422.710 Section 422.710 Employees' Benefits SOCIAL SECURITY ADMINISTRATION ORGANIZATION AND PROCEDURES Use of SSA Telephone Lines § 422.710 Procedures SSA will follow. SSA component(s) that plan to listen-in to or record...

  11. An Update on SSA in Australia

    NASA Astrophysics Data System (ADS)

    Newsam, G.; Gordon, N.

    2011-09-01

    At AMOS 2008 the first author presented a review of surveillance of space activities in Australia up to that date: this paper reviews significant initiatives and events that have taken place since then. In summary some major policy commitments to Space Situational Awareness (SSA) have been made and some sizeable new R&D programs have been launched to develop nascent Australian SSA capabilities. Australia has still to settle on its national requirements for SSA and space generally, however, so these initiatives have yet to evolve into substantial, enduring programs of record. In more detail, the communiqués issued at the annual Australian-US ministerial consultations in November 2010 announced an in-principle commitment to Defence collaboration on SSA and to establishing a joint space tracking facility in Western Australia: Defence in Australia is now working through setting up this facility and how it will move into SSA generally. These are part of a larger national re-engagement with space: in particular in 2009 Australia committed to developing a national space policy and allocated A40 million of funding to a new Australian Space Research Program (ASRP) to boost space research. Over 5 million from this program has been awarded to projects centred on SSA, primarily to enhance EOS’ satellite laser tracking system. In addition to these projects, the partners in an allied Defence R&D agreement that includes DSTO have agreed to a joint experiment that will fly a small formation of suitably instrumented CubeSats with the aim of, inter alia, providing ground truth for testing SSA capabilities. More generally DSTO has been supporting various aspects of Defence’s engagement with SSA, including identification of S&T in which Australia has particular expertise that could be deployed on SSA given the necessary direction. The paper outlines these recent developments, reviews relevant Australian expertise in one particular field, tracking and sensor fusion (the second

  12. Dynamique et interférence de paquets d'ondes dans les atomes et dimères d'alcalins

    NASA Astrophysics Data System (ADS)

    Bouchene, M. A.

    2002-11-01

    (saturation regime, chirped pulse, ...) that allow us to determine the advantages and limits of this technique. In the case of molecules, the interaction of the two-pulse sequence leads to the interference of vibrational wave packets. We analyse and discuss in this case the effects of a thermal distribution of initial states on the temporal coherent control signal. Ce travail porte sur l'étude expérimentale résolue en temps de la dynamique atomique et moléculaire prenant place sur une échelle de temps femtoseconde. Il présente deux orientations distinctes et complémentaires. La première concerne l'étude de la dynamique de paquets d'ondes dans des atomes et dimères d'alcalins (K, K2) par des méthodes pompe-sonde. Dans le cas du potassium atomique le paquet d'ondes est une superposition des états de structure fine de l'état 4p et représente un paquet de spin électronique. Nous observons la dynamique de ce paquet d'ondes au cours du temps et montrons que celle-ci correspond à une inversion du sens d'orientation du spin. Le formalisme théorique des états brillants et noirs est particulièrement adapté à la description de ce type de dynamique. Nous présentons alors une méthode originale qui, tirant avantage du mouvement d'inversion du spin, permet de produire des électrons polarisés en spin à l'échelle femtoseconde. Dans le cas des molécules, le paquet d'ondes créé est une superposition d'états vibrationnels. Nous présentons les résultats d'une étude systématique de la dynamique de paquet d'ondes vibrationnel dans les états électroniques A^1Σ^+_u et 2^1Pi_g. Le signal pompe-sonde dépend alors de la compétition entre les dynamiques associées aux paquets d'ondes créés dans les deux états électroniques. La deuxième partie traite d'expériences d'interférences de paquets d'ondes dans des systèmes similaires (K, Cs, Cs2). Cette technique, complémentaire de la première, consiste à faire interagir une séquence de deux impulsions

  13. BOREAS TGB-9 Above-canopy NMHC at SSA-OBS, SSA-OJP, and SSA-OA Sites

    NASA Technical Reports Server (NTRS)

    Keiser, B. N.; Niki, H.; Young, V. L.; Hall, Forrest G. (Editor); Conrad, Sara K. (Editor)

    2000-01-01

    The BOREAS TGB-9 team collected data in order to inventory and quantify the anthropogenic and biogenic NMHCs over the BOREAS study areas. This data set contains concentration and mixing ratio values for several NMHCs collected at the BOREAS SSA from 27-May-1994 to 15-Sep-1994. The data are provided in tabular ASCII files.

  14. Phosphate fertilizer from sewage sludge ash (SSA).

    PubMed

    Franz, M

    2008-01-01

    Ashes from sewage sludge incineration are rich in phosphorus content, ranging between 4% and 9%. Due to the current methods of disposal used for these ashes, phosphorus, which is a valuable plant nutrient, is removed from biological cycling. This article proposes the possible three-stage processing of SSA, whereby more than 90% of phosphorus can be extracted to make an adequate phosphate fertilizer. SSA from two Swiss sewage sludge incinerators was used for laboratory investigations. In an initial step, SSA was leached with sulfuric acid using a liquid-to-solid ratio of 2. The leaching time and pH required for high phosphorus dissolution were determined. Inevitably, dissolution of heavy metals takes place that would contaminate the fertilizer. Thus in a second step, leach solution has to be purified by having the heavy metals removed. Both ion exchange using chelating resins and sulfide precipitation turned out to be suitable for removing critical Cu, Ni and Cd. Thirdly, phosphates were precipitated as calcium phosphates with lime water. The resulting phosphate sludge was dewatered, dried and ground to get a powdery fertilizer whose efficacy was demonstrated by plant tests in a greenhouse. By measuring the weight of plants after 6 weeks of growth, fertilized in part with conventional phosphate fertilizer, fertilizer made from SSA was proven to be equal in its plant uptake efficiency.

  15. BMDS/SSA Integrated Sensing Demonstration (BISD)

    NASA Astrophysics Data System (ADS)

    Turner, T.; Springford, K.; Grimaldi, L.

    2011-09-01

    This demonstration is intended to provide a near-term prototype, leave-behind capability for integrating Ballistic Missile Defense System (BMDS) ground sensors for use in the Space Situational Awareness (SSA) mission. Closed-loop tasking and cueing capability will be implemented, and a demonstration of net-centric space data dissemination using the BMDS sensors will be undertaken using various SSA mission threads. The demonstration is designed to highlight the implications of modifying software and/or hardware at the BMDS command and control node so that cost, risk, and schedule for an operational implementation can be fully understood. Additionally, this demonstration is intended to assess the impacts to both mission areas as a multi-mission, non-traditional sensor capability is integrated into the SSA mission. A successful demonstration will have many leave-behind capabilities and first-of-its-kind achievements to include: a) an extensible SSA operational prototype configuration for BMDS X-Band radars such as AN/TPY-2 and Sea-Based X-Band (SBX) b) a prototype SSA tasking and cueing capability between the Joint Functional Component Command for Space (JFCC Space) Joint Space Operations Center (JSpOC) and the Command, Control, Battle Management, and Communications (C2BMC) Experimental Laboratory (X-Lab), extensible to the Combatant Commands (COCOMS), and out to BMDS sensors c) a capability for a twoway, net-centric, interface for JSpOC space operations, to include translation from net-centric communications to legacy systems and d) processing of BMDS X-Band Radar tracks in the Space Defense Operations Center (SPADOC).

  16. 20 CFR 416.2005 - Administration agreements with SSA.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Administration agreements with SSA. 416.2005... Administration agreements with SSA. (a) Agreement-mandatory only. Subject to the provisions of paragraph (d) of this section, any State having an agreement with the Social Security Administration (SSA) under § 416...

  17. 20 CFR 416.2005 - Administration agreements with SSA.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Administration agreements with SSA. 416.2005... Administration agreements with SSA. (a) Agreement-mandatory only. Subject to the provisions of paragraph (d) of this section, any State having an agreement with the Social Security Administration (SSA) under § 416...

  18. 20 CFR 416.2005 - Administration agreements with SSA.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Administration agreements with SSA. 416.2005... Administration agreements with SSA. (a) Agreement-mandatory only. Subject to the provisions of paragraph (d) of this section, any State having an agreement with the Social Security Administration (SSA) under § 416...

  19. 20 CFR 416.2005 - Administration agreements with SSA.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Administration agreements with SSA. 416.2005... Administration agreements with SSA. (a) Agreement-mandatory only. Subject to the provisions of paragraph (d) of this section, any State having an agreement with the Social Security Administration (SSA) under § 416...

  20. 20 CFR 416.2005 - Administration agreements with SSA.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Administration agreements with SSA. 416.2005... Administration agreements with SSA. (a) Agreement-mandatory only. Subject to the provisions of paragraph (d) of this section, any State having an agreement with the Social Security Administration (SSA) under § 416...

  1. Evolution of ESA's SSA Conjunction Prediction Service

    NASA Astrophysics Data System (ADS)

    Escobar, D.; Sancho, A. Tirado, J.; Agueda, A.; Martin, L.; Luque, F.; Fletcher, E.; Navarro, V.

    2013-08-01

    This paper presents the recent evolution of ESA's SSA Conjunction Prediction Service (CPS) as a result of an on-going activity in the Space Surveillance and Tracking (SST) Segment of ESA's Space Situational Awareness (SSA) Programme. The CPS is one of a number of precursor services being developed as part of the SST segment. It has been implemented as a service to provide external users with web-based access to conjunction information and designed with a service-oriented architecture. The paper encompasses the following topics: service functionality enhancements, integration with a live objects catalogue, all vs. all analyses supporting an operational concept based on low and high fidelity screenings, and finally conjunction detection and probability algorithms.

  2. Standardized Photometric Calibrations for Panchromatic SSA Sensors

    NASA Astrophysics Data System (ADS)

    Castro, P.; Payne, T.; Battle, A.; Cole, Z.; Moody, J.; Gregory, S.; Dao, P.

    2016-09-01

    Panchromatic sensors used for Space Situational Awareness (SSA) have no standardized method for transforming the net flux detected by a CCD without a spectral filter into an exo-atmospheric magnitude in a standard magnitude system. Each SSA data provider appears to have their own method for computing the visual magnitude based on panchromatic brightness making cross-comparisons impossible. We provide a procedure in order to standardize the calibration of panchromatic sensors for the purposes of SSA. A technique based on theoretical modeling is presented that derives standard panchromatic magnitudes from the Johnson-Cousins photometric system defined by Arlo Landolt. We verify this technique using observations of Landolt standard stars and a Vega-like star to determine empirical panchromatic magnitudes and compare these to synthetically derived panchromatic magnitudes. We also investigate color terms caused by differences in the quantum efficiency (QE) between the Landolt standard system and panchromatic systems. We evaluate calibrated panchromatic satellite photometry by observing several GEO satellites and standard stars using three different sensors. We explore the effect of satellite color terms by comparing the satellite signatures. In order to remove other variables affecting the satellite photometry, two of the sensors are at the same site using different CCDs. The third sensor is geographically separate from the first two allowing for a definitive test of calibrated panchromatic satellite photometry.

  3. Open-Filter Optical SSA Analysis Considerations

    NASA Astrophysics Data System (ADS)

    Lambert, J.

    2016-09-01

    Optical Space Situational Awareness (SSA) sensors used for space object detection and orbit refinement measurements are typically operated in an "open-filter" mode without any spectral filters to maximize sensitivity and signal-to-noise. These same optical brightness measurements are often also employed for size determination (e.g., for orbital debris), object correlation, and object status change. These functions, especially when performed using multiple sensors, are highly dependent on sensor calibration for measurement accuracy. Open-filter SSA sensors are traditionally calibrated against the cataloged visual magnitudes of solar-type stars which have similar spectral distributions as the illuminating source, the Sun. The stellar calibration is performed to a high level of accuracy, a few hundredths of a magnitude, by observing many stars over a range of elevation angles to determine sensor, telescope, and atmospheric effects. However, space objects have individual color properties which alter the reflected solar illumination producing spectral distributions which differ from those of the calibration stars. When the stellar calibrations are applied to the space object measurements, visual magnitude values are obtained which are systematically biased. These magnitudes combined with the unknown Bond albedos of the space objects result in systematically biased size determinations which will differ between sensors. Measurements of satellites of known sizes and surface materials have been analyzed to characterize these effects. The results have combined into standardized Bond albedos to correct the measured magnitudes into object sizes. However, the actual albedo values will vary between objects and represent a mean correction subject to some uncertainty. The objective of this discussion is to characterize the sensor spectral biases that are present in open-filter optical observations and examine the resulting brightness and albedo uncertainties that should accompany

  4. Clients of SSA Net-Ready Data

    NASA Astrophysics Data System (ADS)

    Richmond, D.; Bicker, S.; Malloy, B.

    2014-09-01

    Multiple Net-Centric approaches have been developed to expose optical and radar sensor data. Client applications have been developed to ingest and process this data by NASIC and JMS. Data flows and formats used that integrate these Net-Centric approaches with JMS and NASIC will be presented. Example data collected and examples of improved SSA benefits will be discussed. Potential future improvements to increase the precision of the SOI processing algorithm will be addressed. Specifics regarding the process to gain access to the N-CSDS GEODSS sensor data in near real time will be identified.

  5. BOREAS TE-21 SSA Site Characteristics Data

    NASA Technical Reports Server (NTRS)

    Knox, Robert; Hall, Forrest G. (Editor); Papagno, Andrea (Editor)

    2000-01-01

    The Boreal Ecosystem-Atmospheric Study (BOREAS) TE-20 (Terrestrial Ecology) team collected several data sets for use in developing and testing models of forest ecosystem dynamics. This data set contains measurements of site characteristics conducted in the Southern Study Area (SSA) from 18 Jul 1994 to 30 Jul 1994. The data are stored in CSV files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  6. Idiopathic interstitial lung disease with anti-SSA antibody.

    PubMed

    Boitiaux, Jean-François; Debray, Marie-Pierre; Nicaise-Roland, Pascale; Adle-Biassette, Homa; Danel, Claire; Clérici, Christine; Aubier, Michel; Mariette, Xavier; Cadranel, Jacques; Crestani, Bruno

    2011-12-01

    Consensus is lacking on the immunological tests to perform for diagnosis of interstitial lung diseases (ILDs). In particular, the value of detecting anti-SSA antibody in this context is unknown. We aimed to determine whether the detection of anti-SSA antibody in patients with ILD can identify a subgroup of patients with CTD. We compared the characteristics of patients with newly diagnosed apparently idiopathic ILD with anti-SSA antibody [anti-SSA(+) group] and without anti-SSA antibody (control group). RESULTS; Anti-SSA(+) patients (n = 15) more often had extra-respiratory signs (xerostomia and ocular dryness), auto-immune features, a CT scan pattern of non-specific interstitial pneumonia and more severe lung function alteration than controls (n = 30). Of patients who were anti-SSA(+), 2 met the criteria for SS and 13 (86%) of 15 met the criteria for the diagnosis of undifferentiated CTD. Our results suggest that identification of anti-SSA antibody in patients with early ILD can reveal a specific subgroup of patients with more ground glass opacity and more severe lung function impairment than those without anti-SSA antibody.

  7. BOREAS TE-1 SSA Soil Lab Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Knapp, David E. (Editor); Nerbas, Tim; Anderson, Darwin

    2000-01-01

    This data set was collected by TE-1 to provide a set of soil properties for BOREAS investigators in the SSA. The soil samples were collected at sets of soil pits in 1993 and 1994. Each set of soil pits was in the vicinity of one of the five flux towers in the BOREAS SSA. The collected soil samples were sent to a lab, where the major soil properties were determined. These properties include, but are not limited to, soil horizon; dry soil color; pH; bulk density; total, organic, and inorganic carbon; electric conductivity; cation exchange capacity; exchangeable sodium, potassium, calcium, magnesium, and hydrogen; water content at 0.01, 0.033, and 1.5 MPascals; nitrogen; phosphorus; particle size distribution; texture; pH of the mineral soil and of the organic soil; extractable acid; and sulfur. The data are stored in tabular ASCII text files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  8. 20 CFR 403.155 - Does SSA certify records?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Does SSA certify records? 403.155 Section 403.155 Employees' Benefits SOCIAL SECURITY ADMINISTRATION TESTIMONY BY EMPLOYEES AND THE PRODUCTION OF RECORDS AND INFORMATION IN LEGAL PROCEEDINGS § 403.155 Does SSA certify records? We can certify the...

  9. 20 CFR 416.583 - Findings by SSA.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Findings by SSA. 416.583 Section 416.583 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Payment of Benefits, Overpayments, and Underpayments § 416.583 Findings by SSA. (a) Following the...

  10. 20 CFR 403.155 - Does SSA certify records?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Does SSA certify records? 403.155 Section 403.155 Employees' Benefits SOCIAL SECURITY ADMINISTRATION TESTIMONY BY EMPLOYEES AND THE PRODUCTION OF RECORDS AND INFORMATION IN LEGAL PROCEEDINGS § 403.155 Does SSA certify records? We can certify the...

  11. 20 CFR 404.523 - Findings by SSA.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Findings by SSA. 404.523 Section 404.523 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950... Officer § 404.523 Findings by SSA. (a) Following the hearing or a review of the record, we will issue...

  12. 20 CFR 416.1922 - Your appeal rights in SSA.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Your appeal rights in SSA. 416.1922 Section 416.1922 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Interim Assistance Provisions Appeals § 416.1922 Your appeal rights in SSA. If you...

  13. 20 CFR 404.523 - Findings by SSA.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Findings by SSA. 404.523 Section 404.523 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950... Officer § 404.523 Findings by SSA. (a) Following the hearing or a review of the record, we will issue...

  14. 20 CFR 403.155 - Does SSA certify records?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Does SSA certify records? 403.155 Section 403.155 Employees' Benefits SOCIAL SECURITY ADMINISTRATION TESTIMONY BY EMPLOYEES AND THE PRODUCTION OF RECORDS AND INFORMATION IN LEGAL PROCEEDINGS § 403.155 Does SSA certify records? We can certify the...

  15. 20 CFR 404.523 - Findings by SSA.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Findings by SSA. 404.523 Section 404.523 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950... Officer § 404.523 Findings by SSA. (a) Following the hearing or a review of the record, we will issue...

  16. 20 CFR 416.583 - Findings by SSA.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Findings by SSA. 416.583 Section 416.583 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Payment of Benefits, Overpayments, and Underpayments § 416.583 Findings by SSA. (a) Following the...

  17. 20 CFR 403.155 - Does SSA certify records?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Does SSA certify records? 403.155 Section 403.155 Employees' Benefits SOCIAL SECURITY ADMINISTRATION TESTIMONY BY EMPLOYEES AND THE PRODUCTION OF RECORDS AND INFORMATION IN LEGAL PROCEEDINGS § 403.155 Does SSA certify records? We can certify the...

  18. 20 CFR 416.1922 - Your appeal rights in SSA.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Your appeal rights in SSA. 416.1922 Section 416.1922 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Interim Assistance Provisions Appeals § 416.1922 Your appeal rights in SSA. If you...

  19. 20 CFR 416.583 - Findings by SSA.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Findings by SSA. 416.583 Section 416.583 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Payment of Benefits, Overpayments, and Underpayments § 416.583 Findings by SSA. (a) Following the...

  20. 20 CFR 403.155 - Does SSA certify records?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Does SSA certify records? 403.155 Section 403.155 Employees' Benefits SOCIAL SECURITY ADMINISTRATION TESTIMONY BY EMPLOYEES AND THE PRODUCTION OF RECORDS AND INFORMATION IN LEGAL PROCEEDINGS § 403.155 Does SSA certify records? We can certify the...

  1. 20 CFR 404.523 - Findings by SSA.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Findings by SSA. 404.523 Section 404.523 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950... Officer § 404.523 Findings by SSA. (a) Following the hearing or a review of the record, we will issue...

  2. 20 CFR 416.1922 - Your appeal rights in SSA.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Your appeal rights in SSA. 416.1922 Section 416.1922 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Interim Assistance Provisions Appeals § 416.1922 Your appeal rights in SSA. If you...

  3. 20 CFR 404.523 - Findings by SSA.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Findings by SSA. 404.523 Section 404.523 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950... Officer § 404.523 Findings by SSA. (a) Following the hearing or a review of the record, we will issue...

  4. 20 CFR 416.1922 - Your appeal rights in SSA.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Your appeal rights in SSA. 416.1922 Section 416.1922 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Interim Assistance Provisions Appeals § 416.1922 Your appeal rights in SSA. If you...

  5. 20 CFR 416.583 - Findings by SSA.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Findings by SSA. 416.583 Section 416.583 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Payment of Benefits, Overpayments, and Underpayments § 416.583 Findings by SSA. (a) Following the...

  6. 20 CFR 416.1922 - Your appeal rights in SSA.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Your appeal rights in SSA. 416.1922 Section 416.1922 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Interim Assistance Provisions Appeals § 416.1922 Your appeal rights in SSA. If you...

  7. 20 CFR 416.583 - Findings by SSA.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Findings by SSA. 416.583 Section 416.583 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Payment of Benefits, Overpayments, and Underpayments § 416.583 Findings by SSA. (a) Following the...

  8. 76 FR 41685 - Electronic Substitutions for Form SSA-538

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ... decisionmaking process in SSI childhood cases. Both the SSA-538 and the web-based tool include choices of... review process. Our prior rule required adjudicators at these levels to complete a Form SSA-538, Childhood Disability Evaluation Form, in all cases of children alleging disability or continuing...

  9. BOREAS TE-12 SSA Shoot Geometry Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Walter-Shea, Elizabeth A.; Mesarch, Mark A.; Cheng, L.; Yang, Litao

    2000-01-01

    The Boreal Ecosystem-Atmospheric Study (BOREAS) TE-12 (Terrestrial Ecology) team collected shoot geometry data in 1993 and 1994 from aspen, jack pine, and black spruce trees. Collections were made at the Southern Study Area Nipawin Fen Site (SSA FEN), Young Jack Pine (YJP), Old Jack Pine (OJP), Old Aspen (OA), Young Aspen (YA), Mixed Site (MIX), and Old Black Spruce (OBS) sites. A caliper was used to measure shoot and needle lengths and widths. A volume displacement procedure was used to measure the weight of the shoot or twig submerged in water. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  10. Clinical and laboratory aspects of Ro/SSA-52 autoantibodies.

    PubMed

    Defendenti, Caterina; Atzeni, Fabiola; Spina, Maria Francesca; Grosso, Silvia; Cereda, Aldo; Guercilena, Giacinto; Bollani, Simona; Saibeni, Simone; Puttini, Piercarlo Sarzi

    2011-01-01

    Anti-Ro/SSA antibodies, which were described for the first time in systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS), are the most prevalent extractable nuclear antigen (ENA) specificity identified in laboratories. Two types of anti-Ro/SSA antibodies have been described, anti-SSA-52 kDa (aSSA52) and anti-SSA-60 kDa (aSSA60), each specific to different antigens. Anti-Ro/SSA52 autoantibodies are more frequent than other autoantibodies possibly because of the antigen's accessible and ubiquitous nature. The sites involved and the symptoms associated with these autoantibodies depend on the antigen's structural variability. Isolated congenital complete atrioventricular block (CAVB) shows a close association with maternal anti-Ro/SSA and anti-La/SSB antibodies; the highest relative risks of CAVB are seen in offspring of mothers with antibodies against 52-kDa Ro and 48-kDa La proteins. Anti-Ro/SSA52 antibodies have little impact on adult rheumatic autoimmune diseases or adult cardiac arrhythmias, but the course of autoimmune liver diseases is greatly worsened by their presence, and solid tumours tend to relapse. Their diagnostic role in rheumatic diseases is controversial, although a significant association between isolated anti-Ro/SSA52-kDa positivity and myositis and to a lesser extent with systemic sclerosis (SSc) has been described. However, the majority of the specific diagnosis is mostly based on the simultaneous presence of other autoantibodies that seems diagnostically more relevant.

  11. Anti-SSA antibodies are present in immunoglobulin preparations.

    PubMed

    van der Molen, Renate G; Hamann, Dörte; Jacobs, Joannes F M; van der Meer, Arnold; de Jong, Jan; Kramer, Christine; Strengers, Paul F W; van der Meer, Jos W M

    2015-04-01

    Anti-SSA autoantibodies are among the most frequently detected autoantibodies and have traditionally been associated with Sjögren's syndrome (SjS) and systemic lupus erythematosus. The unexpected finding of anti-SSA antibodies in a patient with common variable immunodeficiency disorder (CVID) treated with intravenous immunoglobulin (IVIG), who developed discoid lupus erythematosus, prompted us to investigate the presence of anti-SSA antibodies in IVIG preparations. Since anti-SSA antibodies may be present in apparently healthy individuals without overt autoimmune features, IVIG preparations may also contain anti-SSA antibodies. IVIG consists of polyclonal immunoglobulin G isolated from the plasma of more than 1000 blood donors. Several IVIG batches from different suppliers and serum samples of patients receiving these IVIG products were tested for the presence of anti-nuclear antibodies (ANAs) and extractable nuclear antibodies (ENAs). In addition, we tested several plasma pools for the presence of anti-SSA and subsequent serum samples of individual donors. Several CVID-patients receiving IVIG tested positive for ANA and anti-SSA. The IVIG products administered also contained clearly detectable concentrations of these antibodies. The frequency of apparently healthy blood donors with anti-SSA positivity was 0.69% and one of 1894 donors (0.05%) showed a very high titer of anti-SSA of more than 10,000 U/mL. Anti-SSA is present in IVIG products and in blood donors without clinical symptoms. IVIG replacement can interfere with ANA and ENA serology by passive transfer of autoantibodies. We hypothesize that such autoantibodies may be causally related to disease manifestations in some recipients. © 2014 AABB.

  12. 77 FR 38880 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Railroad Retirement Board (SSA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-29

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Railroad Retirement Board (SSA... an existing computer matching program that will expire on September 30, 2012. SUMMARY: In accordance... computer matching program that we are currently conducting with RRB. DATES: We will file a report of the...

  13. COMPARISON OF LAPAROSCOPIC SKILLS PERFORMANCE USING SINGLE-SITE ACCESS (SSA) DEVICES VS. AN INDEPENDENT-PORT SSA APPROACH

    PubMed Central

    Schill, Matthew R.; Varela, J. Esteban; Frisella, Margaret M.; Brunt, L. Michael

    2015-01-01

    Background We compared performance of validated laparoscopic tasks on four commercially available single site access (SSA) access devices (AD) versus an independent port (IP) SSA set-up. Methods A prospective, randomized comparison of laparoscopic skills performance on four AD (GelPOINT™, SILS™ Port, SSL Access System™, TriPort™) and one IP SSA set-up was conducted. Eighteen medical students (2nd–4th year), four surgical residents, and five attending surgeons were trained to proficiency in multi-port laparoscopy using four laparoscopic drills (peg transfer, bean drop, pattern cutting, extracorporeal suturing) in a laparoscopic trainer box. Drills were then performed in random order on each IP-SSA and AD-SSA set-up using straight laparoscopic instruments. Repetitions were timed and errors recorded. Data are mean ± SD, and statistical analysis was by two-way ANOVA with Tukey HSD post-hoc tests. Results Attending surgeons had significantly faster total task times than residents or students (p< 0.001), but the difference between residents and students was NS. Pair-wise comparisons revealed significantly faster total task times for the IP-SSA set-up compared to all four AD-SSA’s within the student group only (p<0.05). Total task times for residents and attending surgeons showed a similar profile, but the differences were NS. When data for the three groups was combined, the total task time was less for the IP-SSA set-up than for each of the four AD-SSA set-ups (p < 0.001). Similarly,, the IP-SSA set-up was significantly faster than 3 of 4 AD-SSA set-ups for peg transfer, 3 of 4 for pattern cutting, and 2 of 4 for suturing. No significant differences in error rates between IP-SSA and AD-SSA set-ups were detected. Conclusions When compared to an IP-SSA laparoscopic set-up, single site access devices are associated with longer task performance times in a trainer box model, independent of level of training. Task performance was similar across different SSA

  14. Comparison of laparoscopic skills performance between single-site access (SSA) devices and an independent-port SSA approach.

    PubMed

    Schill, Matthew R; Varela, J Esteban; Frisella, Margaret M; Brunt, L Michael

    2012-03-01

    This study compared the performance of validated laparoscopic tasks on four commercially available single-site-access (SSA) devices with the performance of those tasks on an independent-port (IP) SSA setup. A prospective, randomized comparison of laparoscopic skills performance on four access devices (ADs) (GelPOINT, SILS Port, SSL Access System, TriPort) and one IP-SSA setup was conducted. A laparoscopic trainer box was used to train 18 (2nd- to 4th-year) medical students, four surgical residents, and five attending surgeons to proficiency in multiport laparoscopy using four laparoscopic drills (i.e., peg transfer, bean drop, pattern cutting, extracorporeal suturing). Drills then were performed in random order on each IP-SSA and AD-SSA setup using straight laparoscopic instruments. Repetitions were timed and errors recorded. Data are presented as mean ± standard deviation. Statistical analysis was performed by two-way analysis of variance (ANOVA) with Tukey HSD post hoc tests. The attending surgeons had significantly faster total task times than the residents or students (P < 0.001), but the difference between the residents and students was not significant. Pair-wise comparisons showed significantly faster total task times for the IP-SSA setup than for all four AD-SSAs within the student group only (P < 0.05). The total task times for the residents and attending surgeons showed a similar profile, but the differences were not significant. When the data for the three groups were combined, the total task time was less for the IP-SSA setup than for each of the four AD-SSA setups (P < 0.001). Similarly, the IP-SSA setup was significantly faster than three of the four AD-SSA setups for peg transfer, three of the four setups for pattern cutting, and two of the four setups for suturing. No significant differences in error rates between the IP-SSA and AD-SSA setups were detected. Compared with an IP-SSA laparoscopic setup, AD-SSAs are associated with longer task

  15. ESA-SSA Review of Space Weather Measurement Requirements

    NASA Astrophysics Data System (ADS)

    Luntama, Juha-Pekka; Glover, Alexi; Hilgers, Alain

    2012-07-01

    The ESA Space Situational Awareness (SSA) Preparatory Programme was started in 2009. The objective of the programme is to support the European independent utilisation of and access to space. The first phase of the ESA SSA system development will be finished in 2012 and the next phase is foreseen to be started after the ESA Ministerial Council meeting in November 2012. The definition of measurement requirements for the Space Weather Segment (SWE) of the ESA SSA system has been based on the space weather service requirements defined the by expected users of the system. This document, SSA SWE Customer Requirements Document (CRD), has been defined in a iterative process together with the members of the SSA User Representative Group (URG) and the delegates representing the European states participating the programme. Based on the SWE CRD, ESA with the support of the European industry has produced two documents: SSA SWE System Requirements Document (SRD) and SSA SWE Product Specification (PS). SWE PS contains the requirements for the measurements data required by the SSA SWE system. The SWE PS document has been recently rigorously reviewed by the SSA URG in the framework of the SSA System Requirements Review (SRR). The support provided by the Steering Board of the ESA Space Weather Working Team (SWWT) in this review was extremely useful. The members of the SWWT SB representing the scientific community and the provisional service providers were able to give very detailed comments regarding the measurement requirements for accuracy, cadence, timeliness, etc. As these parameters will be provisional design and cost drivers for the ESA SSA system, definition of the appropriate values at this point in the programme is crucial. This paper provides an overview of the measurement requirements for the SWE Segment of the ESA SSA Programme. The paper discusses the requirement definition process, the customer and service provider inputs, and the critical requirements as they have

  16. The development of the MELiSSA Pilot Plant Facility

    NASA Astrophysics Data System (ADS)

    Godia, Francesc; Dussap, Claude-Gilles; Dixon, Mike; Peiro, Enrique; Fossen, Arnaud; Lamaze, Brigitte; Brunet, Jean; Demey, Dries; Mas-Albaigès, Joan L.

    MELiSSA (Micro-Ecological Life Support System Alternative) is a closed artificial ecosystem intended as a tool for the development of a bio-regenerative life support system for longterm manned missions. The MELiSSA loop is formed by five interconnected compartments, organized in three different loops (solid, liquid and gas). This compartments are microbial bioreactors and higher plant chambers. The MELiSSA Pilot Plant facility has been designed to achieve the preliminary terrestrial demonstration of the MELiSSA concept at pilot scale, using animals as a model for the crew compartent. The experience gained in the operation of such a facility will be highly relevant for planning future life support systems in Space. In this communication, the latests developments in the MELiSSA Pilot Plant will be reported. Particularly, the completion of the design phase and instalation of all the different compartments will be discussed in detail. Each of the compartments had to be designed and constructed according to very specific characteristics, associated to the biological systems to be cultured, as part of the complete MELiSSA loop (anerobic, oxygenic, thermophilic, heterotrophic, autotrophic, axenic, photosynthetic, etc.). Additionally, the sizing of each reactor (ranging from 8 to 100 Liters, depending of each particular compartment) should compile with the global integration scenario proposed, and with the final goal of connection of all compartments to provide a demonstration of the MELiSSA concept, and generate data for the design and operation of future biological life support systems.

  17. Adding the "Local" Layer to the SSA Picture

    NASA Astrophysics Data System (ADS)

    Zaman, F.; Duckett, M.

    2012-09-01

    The heritage of Space Situational Awareness (SSA) has been limited to Earth based observation of space to support collision avoidance and space object identification. In part, this has led to reliance on multiple CONUS locations for optical and non-optical ground based observation. It has also led to the specialization of many fields and industries, which are highlighted at conferences like AMOS through discussion of state-of-the-art of observation capabilities. This paradigm alone no longer addresses the current needs for situational awareness of space assets in the changing space culture. Events in recent years have shown that space based sensing capabilities are increasingly critical as complements to ground based radar and optical systems. The SSA community would be better served by adopting the concept of "local" SSA and proliferating technologies to accomplish this. The traditional definition of SSA would expand to encompass an understanding of the immediate natural and manmade environment of the satellite. Multiple insights would be enabled, including baseline trending to support anomaly identification and resolution, catastrophic failure investigation, and anomaly and/or failure attribution. Additionally, protection measures could potentially be enabled to ensure space asset availability. Moving forward with a combination of traditional SSA and "local" SSA capabilities would allow a potential "global" SSA picture to be developed. This enhanced understanding would consist of ground observations in addition to the satellite's "first person" perspective. The potential for an exponentially increased comprehension of SSA is created by this powerful combination. The first step toward demonstrating this combination of SSA knowledge has been achieved with data from the SASSA Technology Demonstration.

  18. JSpOC SSA: A Year in Review

    NASA Astrophysics Data System (ADS)

    Putnam, S.; McKissock, D.

    2016-09-01

    This paper summarizes significant improvements and changes made by the JSpOC's Space Surveillance Division since the AMOS conference in 2015. It will focus on the areas of spaceflight safety, breakup and debris analysis, reentry processing, launch support, and SSA sharing. In relation to all of these topics, the paper will discuss how the JSpOC has worked with international and industry partners to address SSA challenges, citing current collaboration efforts, as well as specific events. Future initiatives will be presented to provide insight into where the JSpOC's SSA mission is headed in 2017.

  19. BOREAS RSS-1 PARABOLA SSA Surface Reflectance and Transmittance Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Deering, Donald D.; Eck, Thomas F.; Banerjee, Babu

    2000-01-01

    The BOREAS RSS-1 team collected surface reflectance and transmittance data from three forested sites in the SSA. This data set contains averaged reflectance factors and transmitted radiances measured by the PARABOLA instrument at selected sites in the BOREAS SSA at different view angles and at three wavelength bands throughout the day. PARABOLA measurements were made during each of the three BOREAS IFCs during the growing season of 1994 at three SSA tower flux sites as well as during the FFC-T. Additional measurements were made in early and mid-1996 during the FFC-W and during IFC-2. The data are stored in tabular ASCII files.

  20. Differences in the strength of cortical and brainstem inputs to SSA and non-SSA neurons in the inferior colliculus

    PubMed Central

    Ayala, Yaneri A.; Udeh, Adanna; Dutta, Kelsey; Bishop, Deborah; Malmierca, Manuel S.; Oliver, Douglas L.

    2015-01-01

    In an ever changing auditory scene, change detection is an ongoing task performed by the auditory brain. Neurons in the midbrain and auditory cortex that exhibit stimulus-specific adaptation (SSA) may contribute to this process. Those neurons adapt to frequent sounds while retaining their excitability to rare sounds. Here, we test whether neurons exhibiting SSA and those without are part of the same networks in the inferior colliculus (IC). We recorded the responses to frequent and rare sounds and then marked the sites of these neurons with a retrograde tracer to correlate the source of projections with the physiological response. SSA neurons were confined to the non-lemniscal subdivisions and exhibited broad receptive fields, while the non-SSA were confined to the central nucleus and displayed narrow receptive fields. SSA neurons receive strong inputs from auditory cortical areas and very poor or even absent projections from the brainstem nuclei. On the contrary, the major sources of inputs to the neurons that lacked SSA were from the brainstem nuclei. These findings demonstrate that auditory cortical inputs are biased in favor of IC synaptic domains that are populated by SSA neurons enabling them to compare top-down signals with incoming sensory information from lower areas. PMID:25993334

  1. Differences in the strength of cortical and brainstem inputs to SSA and non-SSA neurons in the inferior colliculus.

    PubMed

    Ayala, Yaneri A; Udeh, Adanna; Dutta, Kelsey; Bishop, Deborah; Malmierca, Manuel S; Oliver, Douglas L

    2015-05-20

    In an ever changing auditory scene, change detection is an ongoing task performed by the auditory brain. Neurons in the midbrain and auditory cortex that exhibit stimulus-specific adaptation (SSA) may contribute to this process. Those neurons adapt to frequent sounds while retaining their excitability to rare sounds. Here, we test whether neurons exhibiting SSA and those without are part of the same networks in the inferior colliculus (IC). We recorded the responses to frequent and rare sounds and then marked the sites of these neurons with a retrograde tracer to correlate the source of projections with the physiological response. SSA neurons were confined to the non-lemniscal subdivisions and exhibited broad receptive fields, while the non-SSA were confined to the central nucleus and displayed narrow receptive fields. SSA neurons receive strong inputs from auditory cortical areas and very poor or even absent projections from the brainstem nuclei. On the contrary, the major sources of inputs to the neurons that lacked SSA were from the brainstem nuclei. These findings demonstrate that auditory cortical inputs are biased in favor of IC synaptic domains that are populated by SSA neurons enabling them to compare top-down signals with incoming sensory information from lower areas.

  2. The refolding activity of the yeast heat shock proteins Ssa1 and Ssa2 defines their role in protein translocation

    PubMed Central

    1996-01-01

    Ssa1/2p, members of one of the yeast cytosolic hsp70 subfamilies, have been implicated in the translocation of secretory proteins into the lumen of the ER. The involvement of these hsp70s in translocation was tested directly by examining the effect of immunodepleting Ssa1/2p from yeast cytosol and subsequently testing the cytosol for its ability to support co- and post-translational translocation of prepro-alpha- factor. Depletion of Ssa1/2p had no effect on the efficiency of translocation in this in vitro assay. The system was used to examine the effect of the absence of Ssa1/2p on two other putative hsp70 functions: cotranslational folding of nascent luciferase and refolding of denatured luciferase. Depletion of Ssa1/2p had no effect on the ability of the yeast lysate to synthesize enzymatically active luciferase, but had a dramatic effect on the ability of the lysate to refold chemically denatured luciferase. These results demonstrate, for the first time, the refolding activity of Ssa1/2p in the context of the yeast cytosol, and define refolding activity as a chaperone function specific to Ssa1/2p, aprt from other cytosolic hsp70s. They also suggest that Ssa1/2p do not play a significant role in chaperoning the folding of nascent polypeptides. The implications of these findings for Ssa1/2p activity on their proposed role in the process of translocation are discussed. PMID:8947547

  3. Enabling GEODSS for Space Situational Awareness (SSA)

    NASA Astrophysics Data System (ADS)

    Wootton, S.

    2016-09-01

    The Ground-Based Electro-Optical Deep Space Surveillance (GEODSS) System has been in operation since the mid-1980's. While GEODSS has been the Space Surveillance Network's (SSN's) workhorse in terms of deep space surveillance, it has not undergone a significant modernization since the 1990's. This means GEODSS continues to operate under a mostly obsolete, legacy data processing baseline. The System Program Office (SPO) responsible for GEODSS, SMC/SYGO, has a number of advanced Space Situational Awareness (SSA)-related efforts in progress, in the form of innovative optical capabilities, data processing algorithms, and hardware upgrades. Each of these efforts is in various stages of evaluation and acquisition. These advanced capabilities rely upon a modern computing environment in which to integrate, but GEODSS does not have one—yet. The SPO is also executing a Service Life Extension Program (SLEP) to modernize the various subsystems within GEODSS, along with a parallel effort to implement a complete, modern software re-architecture. The goal is to use a modern, service-based architecture to provide expedient integration as well as easier and more sustainable expansion. This presentation will describe these modernization efforts in more detail and discuss how adopting such modern paradigms and practices will help ensure the GEODSS system remains relevant and sustainable far beyond 2027.

  4. Remote Control Southern Hemisphere SSA Observatory

    NASA Astrophysics Data System (ADS)

    Ritchie, I.; Pearson, M.; Sang, J.

    2013-09-01

    EOS Space Systems (EOSSS) is a research and development company which has developed custom observatories, camera and telescope systems for space surveillance since 1996, as well as creating several evolutions of systems control software for control of observatories and laser tracking systems. Our primary reserach observatory is the Space Reserach Centre (SRC) at Mount Stromlo Asutralia. The current SRC control systems are designed such that remote control can be offered for real time data collection, noise filtering and flexible session management. Several imaging fields of view are available simultaneously for tracking orbiting objects, with real time imaging to Mag 18. Orbiting objects can have the centroids post processed into orbital determination/ orbital projection (OD/OP) elements. With or without laser tracking of orbiting objects, they can be tracked in terminator conditions and their OD/OP data created, then enhanced by proprietary methods involving ballistic coefficient estimation and OD convergence pinning, using a priori radar elements. Sensors in development include a thermal imager for satellite thermal signature detection. Extending laser tracking range by use of adaptive optics beam control is also in development now. This Southern Hemisphere observatory is in a unique position to facilitate the study of space debris, either stand-alone or as part of a network such as Falcon. Current national and international contracts will enhance the remote control capabilities further, creating a resource ready to go for a wide variety of SSA missions.

  5. BOREAS TF-9 SSA-OBS Branch Level Flux Data

    NASA Technical Reports Server (NTRS)

    Rayment, Mark B.; Jarvis, Paul G.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOREAS TF-9 team collected data that describe carbon dioxide and water vapor fluxes from foliage at the BOREAS SSA-OBS site from 07-April through 23-November-1996. The data are available in tabular ASCII files.

  6. The Critical Role of Experimentation to Further SSA Understanding

    NASA Astrophysics Data System (ADS)

    Donnelly, P.; Ash, A.

    2016-09-01

    Dstl has developed an approach to explore the challenges of understanding the fundamental principles of SSA through the design and execution of a series of national and international SSA experiments conducted since 2008. These have involved a number of nations within different multi-lateral constructs (such as Combined Space Operations [CSPO] and NATO), and have also served as test case scenarios in support of international SSA research collaboration. It has been found that this experimentally-driven approach has been successful in linking government R&D activities to actual operations with UK MOD; enabling enhanced cooperation with academia through the provision of access to sensors and data; as well as an understanding of the operational imperatives and constraints, not usually available or apparent to these institutions. The experiences of the Dstl team over the past 8 years have yielded a number of lessons learnt that we believe the wider international community would benefit from in relation to effective SSA operations, including how to generate closer relationships between communities across government, industry, academia and operators. This paper describes the overall Dstl approach to a series of SSA experiments designed to inform the UK MOD on the challenges and potential technical solutions related to SSA mission areas. It includes details of the participants, design and execution; and illustrates some major findings of each event to date. Lessons learnt pertinent to the AMOS and wider SSA community are presented that will inform the audience on how this approach may be adopted to meet other SSA scenarios. Finally, it presents the UK roadmap for future experiments identified as possible activities under the CSPO initiative and the EU Space Surveillance and Tracking programme.

  7. BOREAS TF-11 SSA-Fen Leaf Gas Exchange Data

    NASA Technical Reports Server (NTRS)

    Arkebauer, Timothy J.; Hall, Forrest G. (Editor); Knapp, David E. (Editor)

    2000-01-01

    The BOREAS TF-11 team gathered a variety of data to complement its tower flux measurements collected at the SSA-Fen site. This data set contains single-leaf gas exchange data from the SSA-Fen site during 1994 and 1995. These leaf gas exchange properties were measured for the dominant vascular plants using portable gas exchange systems. The data are stored in tabular ASCII files.

  8. Science opportunities offered by the European SSA-NEO segment

    NASA Astrophysics Data System (ADS)

    Drolshagen, Gerhard; Koschny, Detlef; Bobrinsky, Nicolas

    The new ESA programme on Space Situational Awareness (SSA) initially consists of 3 segments: Space Surveillance and Tracking, Space Weather and Near-Earth Objects (NEO). The scope of the SSA-NEO segment includes the assessment of the impact risk with Earth from known NEOs, observations of NEO objects and the support of related international co-operations and mitigation measures. To fulfill its objectives the SSA-NEO system will , inter alia, support the detection and tracking of all NEOs above a given size or risk threshold, and determine the orbit state and physical parameters of NEOs and their associated uncertainties. It is also foreseen that the SSA-NEO system keeps a record of all larger fireballs and provides statistical information and predictions on meteoroid fluxes. The SSA-NEO segment offers numerous opportunities for scientific studies on small bodies in the solar system. Examples are: 1. Observations of asteroids and NEOs 2. Study of non-gravitational perturbing forces 3. New methods for precise determination of orbits and their evolution 4. Physical characterization of NEOs (Albedo, mass, density, composition, light curves, rotation rate, etc) 5. Fluxes of larger meteoroids This paper gives an overview of the SSA-NEO segment and discusses scientific opportunities offered by this programme.

  9. ESA SSA Space Weather Services Supporting Space Surveillance and Tracking

    NASA Astrophysics Data System (ADS)

    Luntama, Juha-Pekka; Glover, Alexi; Hilgers, Alain; Fletcher, Emmet

    2012-07-01

    ESA Space Situational Awareness (SSA) Preparatory Programme was started in 2009. The objective of the programme is to support the European independent utilisation of and access to space research or services. This will be performed through providing timely and quality data, information, services and knowledge regarding the environment, the threats and the sustainable exploitation of the outer space surrounding the planet Earth. SSA serves the implementation of the strategic missions of the European Space Policy based on the peaceful uses of the outer space by all states, by supporting the autonomous capacity to securely and safely operate the critical European space infrastructures. The Space Weather (SWE) Segment of the SSA will provide user services related to the monitoring of the Sun, the solar wind, the radiation belts, the magnetosphere and the ionosphere. These services will include near real time information and forecasts about the characteristics of the space environment and predictions of space weather impacts on sensitive spaceborne and ground based infrastructure. The SSA SWE system will also include establishment of a permanent database for analysis, model development and scientific research. These services are will support a wide variety of user domains including spacecraft designers, spacecraft operators, human space flights, users and operators of transionospheric radio links, and space weather research community. The precursor SWE services to be established starting in 2010. This presentation provides an overview of the ESA SSA SWE services focused on supporting the Space Surveillance and Tracking users. This services include estimates of the atmospheric drag and archive and forecasts of the geomagnetic and solar indices. In addition, the SSA SWE system will provide nowcasts of the ionospheric group delay to support mitigation of the ionospheric impact on radar signals. The paper will discuss the user requirements for the services, the data

  10. BOREAS TGB-8 Photosynthetic Rate Data over the SSA-OBS and the SSA-OJP

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Conrad, Sara K. (Editor); Lerdau, Manuel

    2000-01-01

    The BOREAS TGB-8 team collected data to investigate the controls over NMHC fluxes from boreal forest tree species. This data set includes measurements of photosynthetic rates at mature jack pine and black spruce sites. The data were collected at the OJP and OBS tower flux locations in the BOREAS SSA. These areas contained mature stands of jack pine and black spruce and were the focal sites in the BOREAS program for studies of biosphere/atmosphere exchange from these two habitat types. The OBS site is situated in a black spruce/sphagnum bog with the largest trees 155 years old and 10-15 m tall. The OJP site is in a jack pine forest, 80 to 120 years old, which lies on a sandy bench of glacial outwash with the largest tree standing 15 m tall. Temporally, the data cover the period of 24-May-1994 to 19-Sep-1994. The data are stored in tabular ASCII files.

  11. B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma/polyp (SSA/P) and cancer in SSA/P

    PubMed Central

    Inoue, A; Okamoto, K; Fujino, Y; Nakagawa, T; Muguruma, N; Sannomiya, K; Mitsui, Y; Takaoka, T; Kitamura, S; Miyamoto, H; Okahisa, T; Fujimori, T; Imoto, I; Takayama, T

    2015-01-01

    Background: Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon cancer with microsatellite instability (MSI). However, the developmental mechanism of SSA/P remains unknown. We performed genetic analysis and genome-wide DNA methylation analysis in aberrant crypt foci (ACF), SSA/P, and cancer in SSA/P specimens to show a close association between ACF and the SSA/P-cancer sequence. We also evaluated the prevalence and number of ACF in SSA/P patients. Methods: ACF in the right-side colon were observed in 36 patients with SSA/Ps alone, 2 with cancers in SSA/P, and 20 normal subjects and biopsied under magnifying endoscopy. B-RAF mutation and MSI were analysed by PCR–restriction fragment length polymorphism (RFLP) and PCR–SSCP, respectively, in 15 ACF, 20 SSA/P, and 2 cancer specimens. DNA methylation array analysis of seven ACF, seven SSA/P, and two cancer in SSA/P specimens was performed using the microarray-based integrated analysis of methylation by isochizomers (MIAMI) method. Results: B-RAF mutations were frequently detected in ACF, SSA/P, and cancer in SSA/P tissues. The number of methylated genes increased significantly in the order of ACF<SSA/PSSA/P were PQLC1, HDHD3, RASL10B, FLI1, GJA3, and SLC26A2. Some of these genes were methylated in ACF, whereas all genes were methylated in cancers. Immunohistochemistry revealed their silenced expression. Microsatellite instability and MLH1 methylation were observed only in cancer. The prevalence and number of ACF were significantly higher in SSA/P patients than in normal subjects. A significant correlation was seen between the numbers of SSA/P and ACF in SSA/P patients. Conclusions: Our results suggest that ACF are precursor lesions of the SSA/P-cancer sequence in patients with SSA/P, where ACF arise by B-RAF mutation and methylation of some of the six identified genes and develop into SSA/Ps through accumulated methylation of these genes. PMID

  12. B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma/polyp (SSA/P) and cancer in SSA/P.

    PubMed

    Inoue, A; Okamoto, K; Fujino, Y; Nakagawa, T; Muguruma, N; Sannomiya, K; Mitsui, Y; Takaoka, T; Kitamura, S; Miyamoto, H; Okahisa, T; Fujimori, T; Imoto, I; Takayama, T

    2015-01-20

    Sessile serrated adenomas/polyps (SSA/Ps) are a putative precursor of colon cancer with microsatellite instability (MSI). However, the developmental mechanism of SSA/P remains unknown. We performed genetic analysis and genome-wide DNA methylation analysis in aberrant crypt foci (ACF), SSA/P, and cancer in SSA/P specimens to show a close association between ACF and the SSA/P-cancer sequence. We also evaluated the prevalence and number of ACF in SSA/P patients. ACF in the right-side colon were observed in 36 patients with SSA/Ps alone, 2 with cancers in SSA/P, and 20 normal subjects and biopsied under magnifying endoscopy. B-RAF mutation and MSI were analysed by PCR-restriction fragment length polymorphism (RFLP) and PCR-SSCP, respectively, in 15 ACF, 20 SSA/P, and 2 cancer specimens. DNA methylation array analysis of seven ACF, seven SSA/P, and two cancer in SSA/P specimens was performed using the microarray-based integrated analysis of methylation by isochizomers (MIAMI) method. B-RAF mutations were frequently detected in ACF, SSA/P, and cancer in SSA/P tissues. The number of methylated genes increased significantly in the order of ACF<SSA/PSSA/P were PQLC1, HDHD3, RASL10B, FLI1, GJA3, and SLC26A2. Some of these genes were methylated in ACF, whereas all genes were methylated in cancers. Immunohistochemistry revealed their silenced expression. Microsatellite instability and MLH1 methylation were observed only in cancer. The prevalence and number of ACF were significantly higher in SSA/P patients than in normal subjects. A significant correlation was seen between the numbers of SSA/P and ACF in SSA/P patients. Our results suggest that ACF are precursor lesions of the SSA/P-cancer sequence in patients with SSA/P, where ACF arise by B-RAF mutation and methylation of some of the six identified genes and develop into SSA/Ps through accumulated methylation of these genes.

  13. [Correlation of anti-60000 SSA antibody and anti-52000 SSA antibody with systemic lupus erythematosus and Sjögren's syndrome].

    PubMed

    Zhang, Feng-Chun; Liu, Li; Xu, Dong

    2007-01-02

    To investigate the correlation of anti-60 000 SSA antibody and anti-52 000 SSA antibody with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). Western blotting against purified 60 000 SSA antigenic polypeptide and 52 000 SSA antigenic polypeptide were done to detect the anti-60 000 SSA and anti-52 000 SSA antibodies in 59 serum samples positive in anti-SSA antibodies, among which 44 samples were from SLE patients and 15 samples from SS patients. There was no significant difference in positive rate of anti-60 000 SSA antibodies between the SLE and pSS patients (P > 0.05). But the sole positive rate of anti-60 000 SSA antibodies of the SLA patients was 39.47% (15/38), significantly higher than that of the primary SS (pSS) patients ((6.67%, 1/15, P < 0.05). The positive rate of anti-52 000 SSA antibodies of the pSS patients was 93.33% (14/15), significantly higher than that of the SLE patients (23/38, 60.53%, P < 0.05). There was no significant differences in positive rates of anti-60 000 SSA antibodies and anti-52 000 SSA antibodies between the secondary SS (sSS) and pSS patients (P > 0.05). The pSS patients mainly present anti-52 000 antibodies and with a very low sole anti-60 000 SSA antibody positive rate. Sole positivity of anti-52 000 SSA antibodies maybe correlated with pSS and is not a strong implication for the diagnosis of sSS. Sole positive anti-60000 SSA antibodies rate can be seen mainly in SLE.

  14. Synthesis of multi-functionalized benzofurans through the condensation of ninhydrin and phenols using SSA as a recyclable heterogeneous acid catalyst.

    PubMed

    Kundu, Ashis; Pramanik, Animesh

    2016-08-01

    A simple and efficient one-pot methodology has been developed for the synthesis of biologically important multi-functionalized 3-(2[Formula: see text]-hydroxyaryl)-2-(2[Formula: see text]-carboxyphenyl)benzofurans using silica sulfuric acid (SSA) as a heterogeneous acid catalyst in DMF medium. The significant advantages of this methodology are the use of SSA as a recyclable solid acid catalyst, operational simplicity, easy availability of the starting materials, and good yield of the products with high atom-economy.

  15. 20 CFR 403.100 - When can an SSA employee testify or produce information or records in legal proceedings?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false When can an SSA employee testify or produce....100 When can an SSA employee testify or produce information or records in legal proceedings? An SSA employee can testify concerning any function of SSA or any information or record created or acquired by SSA...

  16. 20 CFR 422.705 - When SSA employees may listen-in to or record telephone conversations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false When SSA employees may listen-in to or record... ORGANIZATION AND PROCEDURES Use of SSA Telephone Lines § 422.705 When SSA employees may listen-in to or record telephone conversations. SSA employees may listen-in to or record telephone conversations on SSA telephone...

  17. 20 CFR 403.100 - When can an SSA employee testify or produce information or records in legal proceedings?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false When can an SSA employee testify or produce....100 When can an SSA employee testify or produce information or records in legal proceedings? An SSA employee can testify concerning any function of SSA or any information or record created or acquired by SSA...

  18. 20 CFR 403.100 - When can an SSA employee testify or produce information or records in legal proceedings?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false When can an SSA employee testify or produce....100 When can an SSA employee testify or produce information or records in legal proceedings? An SSA employee can testify concerning any function of SSA or any information or record created or acquired by SSA...

  19. 20 CFR 403.100 - When can an SSA employee testify or produce information or records in legal proceedings?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false When can an SSA employee testify or produce....100 When can an SSA employee testify or produce information or records in legal proceedings? An SSA employee can testify concerning any function of SSA or any information or record created or acquired by SSA...

  20. 20 CFR 403.100 - When can an SSA employee testify or produce information or records in legal proceedings?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false When can an SSA employee testify or produce....100 When can an SSA employee testify or produce information or records in legal proceedings? An SSA employee can testify concerning any function of SSA or any information or record created or acquired by SSA...

  1. Multi-Scale SSA or Data-Adaptive Wavelets

    NASA Astrophysics Data System (ADS)

    Yiou, P.; Sornette, D.; Sornette, D.; Sornette, D.; Ghil, M.; Ghil, M.

    2001-05-01

    Using multi-scale ideas from wavelet analysis, the singular-spectrum analysis (SSA) is extended to the study of nonstationary time series, including the case where their variance diverges. The wavelet transform is similar to a local Fourier transform within a finite moving window whose width W, proportional to the major period of interest, is varied to explore a broad range of such periods. SSA, on the other hand, relies on the construction of the lag-correlation matrix C on M lagged copies of the time series over a fixed window width W proportional to M to detect the regular part of the variability in that window in terms of the minimal number of oscillatory components. The proposed multi-scale SSA is a local SSA analysis within a moving window of width M<= W <= N, where N is the length of the time series. Multi-scale SSA varies W, while keeping a fixed W/M ratio, and uses the eigenvectors of the corresponding lag-correlation matrix C(M) as data-adaptive wavelets; successive eigenvectors of C(M) correspond approximately to successive derivatives of the first mother wavelet in standard wavelet analysis. Multi-scale SSA thus solves objectively the delicate problem of optimizing the analyzing wavelet in the time-frequency domain, by a suitable localization of the signal's correlation matrix. We present several examples of application to synthetic signals with fractal or power-law behavior which mimic selected features of certain climatic or geophysical time series. The method is applied to the monthly values of the Southern Oscillation index (SOI) which captures major features of the El Niño/Southern Oscillation in the Tropical Pacific. Our methodology highlights an abrupt periodicity shift in the SOI near 1960. This abrupt shift between 5 and 3 years supports the Devil's staircase scenario for the El Niño/Southern Oscillation phenomenon.

  2. Preliminary approach of the MELiSSA loop energy balance

    NASA Astrophysics Data System (ADS)

    Poulet, Lucie; Lamaze, Brigitte; Lebrun, Jean

    Long duration missions, such as the establishment of permanent bases on the lunar surface or the travel to Mars, require a huge amount of life support consumables (e.g. food, water and oxygen). Current rockets are at the moment unable to launch such a mass from Earth. Consequently Regenerative Life Support Systems are necessary to sustain long-term manned space mission to increase recycling rates and so reduce the launched mass. Thus the European and Canadian research has been concentrating on the MELiSSA (Micro-Ecological Life Support System Alternative) project over the last 20 years. MELiSSA is an Environmental Controlled Life Support System (ECLSS), i.e. a closed regenerative loop inspired of a lake ecosystem. Using light as a source of energy, MELiSSA's goal is the recovery of food, water and oxygen from CO2 and organic wastes, using microorganisms and higher plants. The architecture of a ECLSS depends widely on the mission scenario. To compare several ECLSS architectures and in order to be able to evaluate them, ESA is developing a multi criteria evaluation tool: ALISSE (Advanced LIfe Support System Evaluator). One of these criteria is the energy needed to operate the ECLSS. Unlike other criteria like the physical mass, the energy criterion has not been investigated yet and needs hence a detailed analysis. It will consequently be the focus of this study. The main objective of the work presented here is to develop a dynamic tool able to estimate the energy balance for several configurations of the MELiSSA loop. The first step consists in establishing the energy balance using concrete figures from the MELiSSA Pilot Plant (MPP). This facility located at the Universitat Autonoma de Barcelona (UAB) is aimed at the ground demonstration of the MELiSSA loop. The MELiSSA loop is structured on several subsystems; each of them is characterized by supplies, exhausts and process reactions. For the purpose of this study (i.e. a generic tool) the solver EES (Engineering

  3. Game-theoretic homological sensor resource management for SSA

    NASA Astrophysics Data System (ADS)

    Chin, Sang Peter

    2009-05-01

    We present a game-theoretic approach to Level 2/3/4 fusion for the purpose of Space Situational Awareness (SSA) along with prototypical SW implementation of this approach to demonstrate its effectiveness for possible future space operations. Our approach is based upon innovative techniques that we are developing to solve dynamic games and Nperson cooperative/non-cooperative games, as well as a new emerging homological sensing algorithms which we apply to control disparate network of space sensors in order to gain better SSA.

  4. BOREAS TGB-8 Starch Concentration Data Over the SSA-OBS and the SSA-OJP

    NASA Technical Reports Server (NTRS)

    Lerdau, Manuel; Hall, Forrest G. (Editor); Conrad, Sara K. (Editor)

    2000-01-01

    The BOREAS TGB-8 team collected data to investigate the controls over NMHC fluxes from boreal forest tree species. This data set includes measurements of starch concentrations in foliar samples at mature jack pine and black spruce sites. The data were collected at the OJP and OBS tower flux locations in the BOREAS SSA. These areas contained mature stands of jack pine and black spruce and were the focal sites in the BOREAS program for studies of biosphere/atmosphere exchange from these two habitat types. The OBS site is situated in a black spruce/sphagnum bog with the largest trees 155 years old and 10-15 m tall. The OJP site is in a jack pine forest, 80 to 120 years old, which lies on a sandy bench of glacial outwash with the largest tree standing 15 m tall. Temporally, the data cover the period of 24-May-1994 to 19-Sep-1994. The data are stored in tabular ASCII files.

  5. 20 CFR 411.660 - Is SSA's decision final?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Is SSA's decision final? 411.660 Section 411.660 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Employment Networks and Program Managers §...

  6. 20 CFR 411.630 - Is SSA's decision final?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Is SSA's decision final? 411.630 Section 411.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Beneficiaries and Employment Networks §...

  7. BOREAS TGB-10 Volatile Organic Carbon Data over the SSA

    NASA Technical Reports Server (NTRS)

    Westberg, Hal; Hall, Forrest G. (Editor); Conrad, Sara K. (Editor); Hall, Brad; Jackson, Andrea V.

    2000-01-01

    The BOREAS TGB-10 team collected several trace gas data sets in its efforts to determine the role of biogenic hydrocarbon emissions with respect to boreal forest carbon cycles. This data set contains measured VOC concentrations. These data were obtained at the SSA-OJP site from May to September 1994. The data are stored in tabular ASCII files.

  8. The Benefits Trap: Barriers to Employment Experienced by SSA Beneficiaries

    ERIC Educational Resources Information Center

    Olney, Marjorie F.; Lyle, Cindy

    2011-01-01

    In the first of two rounds of interviews, 12 Social Security Administration (SSA) beneficiaries, all of whom professed a desire to work, discussed their perspectives on barriers to employment. Two years later, 8 of the 12 engaged in a second round of interviews. Only 1 of the 8 participants had succeeded in becoming self-supporting. After a review…

  9. The Benefits Trap: Barriers to Employment Experienced by SSA Beneficiaries

    ERIC Educational Resources Information Center

    Olney, Marjorie F.; Lyle, Cindy

    2011-01-01

    In the first of two rounds of interviews, 12 Social Security Administration (SSA) beneficiaries, all of whom professed a desire to work, discussed their perspectives on barriers to employment. Two years later, 8 of the 12 engaged in a second round of interviews. Only 1 of the 8 participants had succeeded in becoming self-supporting. After a review…

  10. 20 CFR 411.660 - Is SSA's decision final?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Is SSA's decision final? 411.660 Section 411.660 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Employment Networks and Program Managers § 411...

  11. 20 CFR 411.630 - Is SSA's decision final?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Is SSA's decision final? 411.630 Section 411.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Beneficiaries and Employment Networks § 411...

  12. 20 CFR 411.660 - Is SSA's decision final?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Is SSA's decision final? 411.660 Section 411.660 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Employment Networks and Program Managers § 411...

  13. 20 CFR 411.660 - Is SSA's decision final?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Is SSA's decision final? 411.660 Section 411.660 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Employment Networks and Program Managers § 411...

  14. 20 CFR 411.630 - Is SSA's decision final?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Is SSA's decision final? 411.630 Section 411.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Beneficiaries and Employment Networks § 411...

  15. 20 CFR 411.630 - Is SSA's decision final?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Is SSA's decision final? 411.630 Section 411.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Beneficiaries and Employment Networks § 411...

  16. 20 CFR 411.630 - Is SSA's decision final?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Is SSA's decision final? 411.630 Section 411.630 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Beneficiaries and Employment Networks §...

  17. 20 CFR 411.660 - Is SSA's decision final?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Is SSA's decision final? 411.660 Section 411.660 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Ticket to Work Program Dispute Resolution Disputes Between Employment Networks and Program Managers §...

  18. BOREAS TF-1 SSA-OA Soil Characteristics Data

    NASA Technical Reports Server (NTRS)

    Black, T. Andrew; Chen, Z; Nesic, Z.; Hall, Forrest G. (Editor); Papagno, Andrea (Editor)

    2000-01-01

    The BOREAS TF-1 team collected several data sets in support of its efforts to characterize and interpret soil information at the SSA-OA tower site in 1994 as part of BOREAS. Data sets collected include soil respiration, temperature, moisture, and gravimetric data. The data are stored in tabular ASCII format.

  19. Long-term effects of the combination of pegvisomant with somatostatin analogs (SSA) on glucose homeostasis in non-diabetic patients with active acromegaly partially resistant to SSA.

    PubMed

    De Marinis, Laura; Bianchi, Antonio; Fusco, Alessandra; Cimino, Vincenzo; Mormando, Marilda; Tilaro, Laura; Mazziotti, Gherardo; Pontecorvi, Alfredo; Giustina, Andrea

    2007-01-01

    Several recent studies have reported beneficial effects of pegvisomant monotherapy on glucose homeostasis for acromegalic patients resistant to somatostatin analogs (SSA). The aim of our longitudinal study was to test whether these beneficial effects on glucose homeostasis would also occur during combined pegvisomant + SSA treatment amongst partially SSA-resistant acromegalic patients. Ten non-diabetic, partially SSA-resistant acromegalic patients underwent a 12-month SSA+pegvisomant treatment after SSA-only therapy. Glucose homeostasis was evaluated at disease diagnosis, at the end of the SSA treatment and after 6 and 12 months of combined SSA+pegvisomant treatment. The addition of pegvisomant treatment was accompanied by a significant improvement in insulin and glycemic responses to the oral glucose tolerance test, without any significant changes in fasting plasma glucose, glycosylated haemoglobin, homeostatic model assessment-derived insulin resistance index and homeostatic model assessment-derived beta-cell function. Moreover, the number of patients with glucose intolerance did not significantly change during the 12-month combined treatment, notwithstanding the significant decrease in serum IGF-1 values. Therefore, our findings suggest that the combined pegvisomant and SSA treatment may not be able to restore normal clinical and biochemical glycometabolic features occurring in acromegalic patients resistant to SSA, while a slight but significant improvement in some biochemical features may be expected.

  20. 20 CFR 429.110 - Are there any limitations on SSA's authority under this subpart?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Are there any limitations on SSA's authority... the Federal Tort Claims Act § 429.110 Are there any limitations on SSA's authority under this subpart... with the Department of Justice when, in the opinion of SSA: (1) A new precedent or a new point of law...

  1. 20 CFR 429.110 - Are there any limitations on SSA's authority under this subpart?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Are there any limitations on SSA's authority... the Federal Tort Claims Act § 429.110 Are there any limitations on SSA's authority under this subpart... with the Department of Justice when, in the opinion of SSA: (1) A new precedent or a new point of law...

  2. DAN DORNEY

    NASA Image and Video Library

    2016-03-16

    CHIEF ENGINEER OF THE LAUNCH VEHICLE FOR NASA'S COMMERCIAL CREW PROGRAM, DAN DORNEY GUIDES THE TEAM EVALUATING THE VEHICLES CREATED BY INDUSTRY PARTNERS AND ENSURES THE ROCKETS MEET THE REQUIREMENTS TO SAFELY CARRY ASTRONAUTS TO THE INTERNATIONAL SPACE STATION.

  3. Molecular studies of Ssa1, a serotype-specific antigen of Pasteurella haemolytica A1.

    PubMed Central

    Lo, R Y; Strathdee, C A; Shewen, P E; Cooney, B J

    1991-01-01

    A serotype-specific antigen of Pasteurella haemolytica A1 encoded on the recombinant plasmid pSSA1 is characterized. Nucleotide sequence analysis of the insert DNA in pSSA1 identified the gene ssaI, which codes for a protein of approximately 100 kDa. In vivo labeling of pSSA1-encoded protein in Escherichia coli maxicells showed the expression of a 100-kDa protein from the insert DNA on the recombinant plasmid. Northern blot and primer extension analyses were used to identify the mRNA transcript in P. haemolytica A1 and the putative promoter of ssaI. The antigen (designated Ssa1) could be localized to the outer membrane of P. haemolytica A1 and E. coli clones carrying pSSA1. A rabbit serum against Ssa1 was produced by using whole cells of E. coli expressing Ssa1 on the surface as the immunogen, demonstrating that Ssa1 is immunogenic in rabbits. The results from colony immunoblot analysis with calf serum from animals that were resistant to P. haemolytica A1-induced pneumonia suggest indirectly that Ssa1 is also immunogenic in the animals. Images PMID:1840576

  4. Detection of serum IgE class anti-SSA antibodies in mothers with foetal loss.

    PubMed

    Sekigawa, Iwao; Kaneda, Kazuhiko; Kaneko, Hiroshi; Takasaki, Yoshinari; Takamori, Kenji; Ogawa, Hideoki

    2008-05-01

    We previously reported a close relationship between serum immunoglobulin (Ig)E and anti-SSA antibody levels in mothers with foetal loss. Here, we investigated the existence of IgE class anti-SSA antibodies (IgE anti-SSA antibody) and the relationship of such antibodies with foetal loss. Serum samples from 24 women who were positive for IgG class anti-SSA antibody (IgG anti-SSA antibody) were examined for IgE anti-SSA antibody by enzyme-linked immunosorbent assay (ELISA). Then, a retrospective analysis of the relationship between the IgE anti-SSA antibody positivity and the frequency of foetal loss was performed. Using our ELISA system, IgE anti-SSA antibodies were detected in the serum samples, and the frequency of foetal loss was increased among the mothers with higher IgE anti-SSA antibody titers. Our results indicate that IgE anti-SSA antibodies may be a useful marker for the risk of foetal loss in mothers with anti-SSA antibodies.

  5. Host Cell Invasion and Virulence Mediated by Candida albicans Ssa1

    PubMed Central

    Sun, Jianing N.; Solis, Norma V.; Phan, Quynh T.; Bajwa, Jashanjot S.; Kashleva, Helena; Thompson, Angela; Liu, Yaoping; Dongari-Bagtzoglou, Anna; Edgerton, Mira; Filler, Scott G.

    2010-01-01

    Candida albicans Ssa1 and Ssa2 are members of the HSP70 family of heat shock proteins that are expressed on the cell surface and function as receptors for antimicrobial peptides such as histatins. We investigated the role of Ssa1 and Ssa2 in mediating pathogenic host cell interactions and virulence. A C. albicans ssa1Δ/Δ mutant had attenuated virulence in murine models of disseminated and oropharyngeal candidiasis, whereas an ssa2Δ/Δ mutant did not. In vitro studies revealed that the ssa1Δ/Δ mutant caused markedly less damage to endothelial cells and oral epithelial cell lines. Also, the ssa1Δ/Δ mutant had defective binding to endothelial cell N-cadherin and epithelial cell E-cadherin, receptors that mediate host cell endocytosis of C. albicans. As a result, this mutant had impaired capacity to induce its own endocytosis by endothelial cells and oral epithelial cells. Latex beads coated with recombinant Ssa1 were avidly endocytosed by both endothelial cells and oral epithelial cells, demonstrating that Ssa1 is sufficient to induce host cell endocytosis. These results indicate that Ssa1 is a novel invasin that binds to host cell cadherins, induces host cell endocytosis, and is critical for C. albicans to cause maximal damage to host cells and induce disseminated and oropharyngeal disease. PMID:21085601

  6. BOREAS TE-18 Biomass Density Image of the SSA

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Knapp, David

    2000-01-01

    The BOREAS TE-18 team focused its efforts on using remotely sensed data to characterize the successional and disturbance dynamics of the boreal forest for use in carbon modeling. This biomass density image covers almost the entire BOREAS SSA. The pixels for which biomass density is computed include areas, that are in conifer land cover classes only. The biomass density values represent the amount of overstory biomass (i.e., tree biomass only) per unit area. It is derived from a Landsat-5 TM image collected on 02-Sep-1994. The technique that was used to create this image is very similar to the technique that was as used to create the physical classification of the SSA. The data are provided in a binary image file format. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Activity Archive Center (DAAC).

  7. A total and biosafe liquefaction compartment for MELiSSA

    NASA Astrophysics Data System (ADS)

    Verstraete, W.; Albrecht, T.; Kübe, J.; Dussap, G.; Creuly, C.

    2005-10-01

    Envisaging long-duration space missions and settlements on the Moon or even on more distant planets means considering the production of food and the recycling of scarce, valuable chemical species from waste. ESA's MELiSSA project (Micro-Ecological Life Support System Alternative) is studying, in which five different compartments degrade waste into basic chemicals and then assimilate them into food, clean water and a breathable atmosphere. Crucial to the success of such a closed system is the absolute efficiency of the first compartment, in which all waste is biologically degraded into easily assimilable basic compounds. In order to ease this strenuous task and to ensure total and biosafe liquefaction of the waste, this MAP project is studying additional technologies that complement MELiSSA's waste degrading compartment.

  8. International and NASA SSA and Safety of Flight Issues

    NASA Technical Reports Server (NTRS)

    Johnson, Nicholas K,

    2010-01-01

    This presentation reviews the international and NASA interests in Space Situational Awareness (SSA) and space debris as it affects space flight safety. The international interesrt has increased since the collision of the Iridium and Cosmos satellites in 2009. The United Nations Committee on the Peaceful Uses of Outer Space (UN COPUOS) has commenced a multi-year effort to review the long-term sustainability of outer space activities.

  9. Systematic Sustainability Assessment (SSA) Tool for Hydroelectric Project in Malaysia

    NASA Astrophysics Data System (ADS)

    Turan, Faiz Mohd; Johan, Kartina

    2017-08-01

    Sustainably developed and managed hydropower has enormous potential to contribute to global sustainability goals. It is known that hydroelectricity contributing small amounts to greenhouse gas emissions and other atmospheric pollutants. However, developing the remaining hydroelectric potential offers many challenges, and public pressure and expectations on the environmental and social performance of hydroelectric tend to increase over time. This paper aims to develop Systematic Sustainability Assessment (SSA) Tool that promotes and guides more sustainable hydroelectric projects in the context of Malaysia. The proposed SSA tool which not only provide a quality and quantitative report of sustainability performance but also act as Self-Assessment Report (SAR) to provide roadmap to achieve greater level of sustainability in project management for continuous improvement. It is expected to provide a common language that allow government, civil society, financial institutions and the hydroelectric sector to talk about and evaluate sustainability issues. The advantage of SSA tool is it can be used at any stage of hydroelectric development, from the earliest planning stages right through to operation.

  10. 20 CFR 408.1205 - How can a State have SSA administer its State recognition payment program?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false How can a State have SSA administer its State... § 408.1205 How can a State have SSA administer its State recognition payment program? A State (or political subdivision) may enter into a written agreement with SSA, under which SSA will make recognition...

  11. 20 CFR 408.1205 - How can a State have SSA administer its State recognition payment program?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false How can a State have SSA administer its State... § 408.1205 How can a State have SSA administer its State recognition payment program? A State (or political subdivision) may enter into a written agreement with SSA, under which SSA will make recognition...

  12. 20 CFR 408.1205 - How can a State have SSA administer its State recognition payment program?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false How can a State have SSA administer its State... § 408.1205 How can a State have SSA administer its State recognition payment program? A State (or political subdivision) may enter into a written agreement with SSA, under which SSA will make recognition...

  13. 20 CFR 408.1205 - How can a State have SSA administer its State recognition payment program?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false How can a State have SSA administer its State... § 408.1205 How can a State have SSA administer its State recognition payment program? A State (or political subdivision) may enter into a written agreement with SSA, under which SSA will make recognition...

  14. Arrhythmogenic effects of anti-Ro/SSA antibodies on the adult heart: more than expected?

    PubMed

    Lazzerini, Pietro Enea; Capecchi, Pier Leopoldo; Acampa, Maurizio; Selvi, Enrico; Guideri, Francesca; Bisogno, Stefania; Rossi, Pier Carlo; Galeazzi, Mauro; Pasini, Franco Laghi

    2009-09-01

    The arrhythmogenicity of anti-Ro/SSA antibodies for the foetal heart and their crucial role in the development of congenital heart block is now well established, representing a paradigmatic model of passively acquired autoimmunity. Recently, intriguing data suggest that also the adult heart may represent a possible target of anti-Ro/SSA antibody-mediated autoimmune injury. The prolongation of the QTc interval, possibly resulting from a direct inhibitory interaction between the anti-Ro/SSA antibodies and the potassium current I(Kr) in the heart seems the abnormality more frequently observed in adults with anti-Ro/SSA-positive CTD. Although the possibility that anti-Ro/SSA positivity may be considered a risk factor for arrhythmic sudden death in adults has not been demonstrated as yet, preliminary data suggest a relationship among anti-Ro/SSA antibodies, QTc prolongation, and the prevalence of ventricular arrhythmias, also life threatening, in adult patients.

  15. BOREAS TF-11 Biomass Data over the SSA-Fen

    NASA Technical Reports Server (NTRS)

    Valentine, David W.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOREAS TF-11 team collected several data sets in its efforts to fully describe the flux and site characteristics at the SSA-Fen site. This data set contains plant cover, standing crop of plant biomass, and estimated net primary productivity at each chamber site at the end of the 1994 field season. The measurements were conducted as part of a 2 x 2 factorial experiment in which we added carbon (300 g/sq m as wheat straw) and nitrogen (6 g/sq m as urea) to four replicate locations in the vicinity of the TF-11 tower. The data are stored in tabular ASCII files.

  16. BOREAS TE-12 SSA Leaf Water Potential Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Walter-Shea, Elizabeth A.; Mesarch, Mark A.; Chen, L.; Yang, Litao

    2000-01-01

    The Boreal Ecosystem-Atmospheric Study (BOREAS) TE-12 (Terrestrial Ecology) team collected water potential data in 1993 and 1994 from aspen, jack pine, and black spruce leaves/needles. Collections were made at the Southern Study Area Nipawin Fen Site (SSA FEN), Young Jack Pine (YJP), Young Aspen (YA), Old Aspen (OA), and Old Black Spruce (OBS) sites. Measurements were made using a pressure chamber on a platform in the field. The data are provided in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  17. BOREAS TF-11 Decomposition Data over the SSA-Fen

    NASA Technical Reports Server (NTRS)

    Valentine, David W.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOREAS TF-11 team collected several data sets in its efforts to fully describe the flux and site characteristics at the SSA-Fen site. This data set contains decomposition rates of a standard substrate (wheat straw) across treatments. The measurements were conducted in 1994 as part of a 2 x 2 factorial experiment in which we added carbon (300 g/sq m as wheat straw) and nitrogen (6 g/sq m as urea) to four replicate locations in the vicinity of the TF-11 tower. The data are stored in tabular ASCII files.

  18. Use of sewage sludge ash (SSA)-cement admixtures in mortars

    SciTech Connect

    Monzo, J.; Paya, J.; Borrachero, M.V.; Corcoles, A.

    1996-09-01

    The chemical composition of sewage sludge ash (SSA) and their sized fractions are studied; some differences in chemical composition are observed. SEM studies show irregular shape of SSA particles and sized fractions, this shape has a decisive influence on workability of mortars. The effect of replacing 15% of portland cement by SSA and their sized fractions: coarse (SSAC) and medium (SSAM) obtained by sieving on compressive (R{sub c}) and flexural (R{sub f}) strength of mortars was investigated. The study reveals an enhancement of strength when ashes are used, due to probably, pozzolanic properties of SSA.

  19. BOREAS TE-1 SSA-Fen Soil Profile Nutrient Data

    NASA Technical Reports Server (NTRS)

    Papagno, Andrea; Anderson, Darwin; Newcomer, Jeffrey A. (Editor); Hall, Forrest G. (Editor)

    2000-01-01

    The BOREAS TE-1 team collected various data to characterize the soil-plant systems in the BOREAS SSA. Particular emphasis was placed on nutrient biochemistry, the stores and transfers of organic carbon, and how the characteristics were related to measured methane fluxes. The overall traniect in the Prince Albert National Park (Saskatchewan, Canada) included the major plant communities and related soils that occurred in that section of the boreal forest. Soil physical, chemical, and biological measurements along the transect were used to characterize the static environment, which allowed them to be related to methane fluxes. Chamber techniques were used to provide a measure of methane production/uptake. Chamber measurements coupled with flask sampling were used to determine the seasonality of methane fluxes. This particular data set contains soil profile measurements of various nutrients at the SSA-Fen site. The data were collected from 23-May to 21-Oct- 1994. The data are stored in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  20. Is identification of anti-SSA and/or -SSB antibodies necessary in serum samples referred for antinuclear antibodies testing?

    PubMed

    Yang, Zaixing; Liang, Yan; Zhong, Renqian

    2012-11-01

    Anti-SSA and -SSB antibodies are clinically important antinuclear antibodies in patients with systemic rheumatic diseases. We evaluated fluorescence characteristics and clinical significance of anti-SSA and -SSB and explored whether identification of these antibodies was necessary in clinical application. Of 4,978 consecutive samples, 259 showed anti-SSA or -SSB reactivity, clinical information of which were analyzed. Compared with SSA+SSB- and SSA-SSB+ group, SSA+SSB+ group showed a lower proportion (0.5%) of negative specimens detected with antinuclear antibody assay and a higher proportion (53.5%) of specimens with high titer. Anti-SSA- and/or -SSB-positive samples presented various patterns. However, 64.6% of SSA+SSB+ samples presented speckled pattern, significantly higher than SSA+SSB- and SSA-SSB+ samples. A total of 475 specimens containing anti-SSA or -SSB were obtained from 302 individuals. Clinical information was obtained for 259 of them, which were further analyzed. The prevalence of Sjögren syndrome (SS) was significantly higher, and that of other diseases was lower in SSA+SSB+ than in SSA+SSB- group. Of the 259 individuals, 71 anti-SSA- and/or -SSB-positive patients had blood drawn on 2 or more occasions over the 2-year study period. The number of tests per patient was 2.7 ± 1.1. In 7 of the 71 patients, anti-SSA was observed in some but not all samples, so was anti-SSB in 6. In conclusion, the identification of anti-SSA and -SSB antibodies is necessary, when corresponding diseases are suspected. The specificity of anti-SSA for the diagnosis of SS could be improved, when combined with anti-SSB. SS patients need not be identified frequently for anti-SSA and -SSB because of their stability. © 2012 Wiley Periodicals, Inc.

  1. Comparisons of double immunodiffusion, ELISA, western blot and CAPE blot for the detection of anti-SSA antibody: study of anti-SSA prevalence in systemic lupus erythematosus.

    PubMed

    Chretien, P; Soulie, E; Johanet, C; Abuaf, N

    1994-06-01

    The specificity and sensitivity of anti-SSA (Ro) antibody detection by double immunodiffusion, ELISA, western blot and a new method named CAPE blot were studied. Using 79 normal sera, 61 sera positive for anti-SSA (Ro) antibodies (double immunodiffusion), and 39 sera without anti-SSA (Ro) antibodies but containing anti-Sm, anti-RNP, anti-SSB (La), anti-Scl 70 and anti-PCNA antibodies, we compared ELISA, western blot and CAPE blot with the immunodiffusion assay. The sensitivities of the three methods were 100, 62 and 100%, respectively. Sera from 196 patients with systemic lupus erythematosus (SLE) were tested. The prevalence of anti-SSA (Ro) antibodies in this group was scored as 26% by double immunodiffusion, 47% by ELISA, 25% by western blot and 38% by CAPE blot.

  2. 20 CFR 411.330 - How will SSA evaluate an EN's performance?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How will SSA evaluate an EN's performance? 411.330 Section 411.330 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Networks § 411.330 How will SSA evaluate an EN's performance? (a) We...

  3. 20 CFR 411.330 - How will SSA evaluate an EN's performance?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false How will SSA evaluate an EN's performance? 411.330 Section 411.330 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Networks § 411.330 How will SSA evaluate an EN's performance? (a) We will...

  4. Cloning, expression and interaction of human T-cell receptors with the bacterial superantigen SSA.

    PubMed

    De Marzí, Mauricio C; Fernández, Marisa M; Sundberg, Eric J; Molinero, Luciana; Zwirner, Norberto W; Llera, Andrea S; Mariuzza, Roy A; Malchiodi, Emilio L

    2004-10-01

    Superantigens (SAgs) are a class of disease-causing and immunostimulatory proteins of bacterial or viral origin that activate a large number of T-cells through interaction with the Vbeta domain of T-cell receptors (TCRs). In this study, recombinant TCR beta chains were constructed with human variable domains Vbeta5.2, Vbeta1 and Vbeta2.1, expressed as inclusion bodies, refolded and purified. The Streptococcus pyogenes SAg SSA-1 was cloned and expressed as a soluble periplasmic protein. SSA-1 was obtained both as a monomer and a dimer that has an intermolecular disulfide bond. We analyzed the biological activity of the recombinant SAgs by proliferation assays. The results suggest that SSA dimerization occludes the TCR interaction site. Naturally occurring SSA dimerization was also observed in supernatants of S. pyogenes isolates. An SSA mutant [SSA(C26S)] was produced to eliminate the Cys responsible for dimerization. Affinity assays using a resonant biosensor showed that both the mutant and monomeric wild type SSA have affinity for human Vbeta5.2 and Vbeta1 with Kd of 9-11 microm with a fast kass and a moderately fast kdiss. In spite of the reported stimulation of Vbeta2.1 bearing T-cells by SSA, we observed no measurable interaction.

  5. 77 FR 54943 - Privacy Act of 1974, as Amended; Computer Matching Program (Social Security Administration (SSA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ...)/Department of Veterans Affairs (VA), Veterans Benefits Administration (VBA))--Match Number 1309 AGENCY: SSA... protections for persons applying for, and receiving, Federal benefits. Section 7201 of the Omnibus Budget... benefits or payments. ] B. SSA Computer Matches Subject to the Privacy Act We have taken action to...

  6. Hearings by administrative law judges of certain Medicare claims--HCFA, SSA. General notice.

    PubMed

    1988-06-01

    This notice is to advise the public that the Social Security Administration's Office of Hearings and Appeals (SSA, OHA) has recently been given temporary jurisdiction over Medicare Part B, Supplementary Medical Insurance, Administrative Law Judge (ALJ) hearings. Medicare Part A, Hospital Insurance, ALJ hearings and Medicare entitlement matters continue under SSA, OHA's jurisdiction.

  7. 20 CFR 439.400 - What are my responsibilities as an SSA awarding official?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What are my responsibilities as an SSA awarding official? 439.400 Section 439.400 Employees' Benefits SOCIAL SECURITY ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Responsibilities of SSA Awarding...

  8. 77 FR 43639 - Privacy Act of 1974, as Amended; Computer Matching Program (Social Security Administration (SSA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (Social Security Administration (SSA..., SSA, as shown above. SUPPLEMENTARY INFORMATION: A. General The Computer Matching and Privacy... persons. The Privacy Act, as amended, regulates the use of computer matching by Federal agencies...

  9. 20 CFR 402.25 - Referral of requests outside of SSA.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Referral of requests outside of SSA. 402.25 Section 402.25 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC § 402.25 Referral of requests outside of SSA. If you request records that were created...

  10. 20 CFR 402.25 - Referral of requests outside of SSA.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Referral of requests outside of SSA. 402.25 Section 402.25 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC § 402.25 Referral of requests outside of SSA. If you request records that were created...

  11. 20 CFR 402.25 - Referral of requests outside of SSA.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Referral of requests outside of SSA. 402.25 Section 402.25 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC § 402.25 Referral of requests outside of SSA. If you request records that were created...

  12. Toxicity, membrane binding and uptake of the Sclerotinia sclerotiorum agglutinin (SSA) in different insect cell lines.

    PubMed

    Shen, Ying; De Schutter, Kristof; Walski, Tomasz; Van Damme, Els J M; Smagghe, Guy

    2017-07-11

    The fungal lectin purified from Sclerotinia sclerotiorum, further referred to as Sclerotinia sclerotiorum agglutinin or SSA, possesses insecticidal activity against important pest insects such as pea aphids (Acyrthosiphon pisum). This paper aims at a better understanding of its activity at cellular level. Therefore, different insect cell lines were treated with SSA. These cell lines were derived from different tissues and represent the three major orders of insects important in agriculture: CF-203 (midgut Choristoneura fumiferana, Lepidoptera), GUTAW1 (midgut, Helicoverpa zea, Lepidoptera), High5 cells (ovary, Trichoplusia ni, Lepidoptera), Sf9 (ovary cells from Spodoptera frugiperda, Lepidoptera), S2 (hemocyte, Drosophila melanogaster, Diptera), and TcA (whole body, Tribolium castaneum, Coleoptera). Although the sensitivity to SSA differs between the cell lines, SSA clearly showed toxicity in all six cell lines with median effect concentrations (EC50) ranging between 9 and 42 μg/ml. An in-depth analysis of the mechanism of uptake in the cells revealed superior amounts of FITC-SSA at the membrane of CF-203 cells compared to Sf9 cells, while a similar small amount of SSA was internalized in both cell lines. Pre-incubation with the clathrin-mediated endocytosis inhibitor phenylarsine oxide inhibited the internalization of SSA into the CF-203 and Sf9 cells with a respective reduction of 6- and 1.7-fold. The data are discussed in relation to the importance of cellular uptake mechanism for SSA binding and cytotoxicity.

  13. 20 CFR 402.25 - Referral of requests outside of SSA.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Referral of requests outside of SSA. 402.25 Section 402.25 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC § 402.25 Referral of requests outside of SSA. If you request records that were created...

  14. 20 CFR 402.25 - Referral of requests outside of SSA.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Referral of requests outside of SSA. 402.25 Section 402.25 Employees' Benefits SOCIAL SECURITY ADMINISTRATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC § 402.25 Referral of requests outside of SSA. If you request records that were created...

  15. 20 CFR 411.330 - How will SSA evaluate an EN's performance?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false How will SSA evaluate an EN's performance? 411.330 Section 411.330 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Networks § 411.330 How will SSA evaluate an EN's performance? (a) We...

  16. Arrhythmogenicity of Anti-Ro/SSA Antibodies in Patients With Torsades de Pointes.

    PubMed

    Lazzerini, Pietro Enea; Yue, Yuankun; Srivastava, Ujala; Fabris, Frank; Capecchi, Pier Leopoldo; Bertolozzi, Iacopo; Bacarelli, Maria Romana; Morozzi, Gabriella; Acampa, Maurizio; Natale, Mariarita; El-Sherif, Nabil; Galeazzi, Mauro; Laghi-Pasini, Franco; Boutjdir, Mohamed

    2016-04-01

    In patients with autoimmune disease, anti-Ro/SSA antibodies (anti-Ro/SSA) are responsible for a novel autoimmune-associated long-QT syndrome by targeting the hERG potassium channel and inhibiting the related current (IKr). Because anti-Ro/SSA are also present in a significant proportion of healthy subjects and may be associated with torsades de pointes (TdP) arrhythmia, we tested the hypothesis that anti-Ro/SSA may represent a silent risk factor in patients developing TdP. Twenty-five consecutive patients who experienced TdP were prospectively collected independent of ongoing therapies and concomitant diseases. Anti-Ro/SSA were detected by fluoroenzyme immunoassay, immuno-Western blotting, and line-blot immunoassay. Purified IgGs from anti-Ro/SSA-positive and anti-Ro/SSA-negative patients were tested on IKr using HEK293 cells stably expressing the hERG channel. As expected, in TdP patients, many known corrected QT interval-prolonging risk factors were simultaneously present, including hypokalemia that was the most common (52%). Anti-Ro/SSA were present in 60% of the subjects, mostly the anti-Ro/SSA-52-kD subtype detected by immuno-Western blotting only. A history of autoimmune disease was found in only 2 of anti-Ro/SSA-positive patients. Experimental data demonstrated that purified anti-Ro/SSA-positive IgGs significantly inhibited IKr and cross reacted with hERG-channel proteins. Moreover, anti-Ro/SSA-positive sera exhibited high reactivity with a peptide corresponding to the hERG-channel pore-forming region. Anti-Ro/SSA may represent a clinically silent novel risk factor for TdP development via an autoimmune-mediated electrophysiological interference with the hERG channel. We propose that TdP patients may benefit from specific anti-Ro/SSA testing even in the absence of autoimmune diseases as immunomodulating therapies may be effective in shortening corrected QT interval and reducing TdP recurrence risk. © 2016 American Heart Association, Inc.

  17. The organic fraction of bubble-generated, accumulation mode Sea Spray Aerosol (SSA)

    NASA Astrophysics Data System (ADS)

    Modini, R. L.; Harris, B.; Ristovski, Z. D.

    2010-03-01

    Recent studies have detected a dominant accumulation mode (~100 nm) in the Sea Spray Aerosol (SSA) number distribution. There is evidence to suggest that particles in this mode are composed primarily of organics. To investigate this hypothesis we conducted experiments on NaCl, artificial SSA and natural SSA particles with a Volatility-Hygroscopicity-Tandem-Differential-Mobility-Analyser (VH-TDMA). NaCl particles were atomiser generated and a bubble generator was constructed to produce artificial and natural SSA particles. Natural seawater samples for use in the bubble generator were collected from biologically active, terrestrially-affected coastal water in Moreton Bay, Australia. Differences in the VH-TDMA-measured volatility curves of artificial and natural SSA particles were used to investigate and quantify the organic fraction of natural SSA particles. Hygroscopic Growth Factor (HGF) data, also obtained by the VH-TDMA, were used to confirm the conclusions drawn from the volatility data. Both datasets indicated that the organic fraction of our natural SSA particles evaporated in the VH-TDMA over the temperature range 170-200 °C. The organic volume fraction for 71-77 nm natural SSA particles was 8±6%. Organic volume fraction did not vary significantly with varying water residence time (40 s to 24 h) in the bubble generator or SSA particle diameter in the range 38-173 nm. At room temperature we measured shape- and Kelvin-corrected HGF at 90% RH of 2.46±0.02 for NaCl, 2.35±0.02 for artifical SSA and 2.26±0.02 for natural SSA particles. Overall, these results suggest that the natural accumulation mode SSA particles produced in these experiments contained only a minor organic fraction, which had little effect on hygroscopic growth. Our measurement of 8±6% is an order of magnitude below two previous measurements of the organic fraction in SSA particles of comparable sizes. We stress that our results were obtained using coastal seawater and they can't necessarily

  18. The organic fraction of bubble-generated, accumulation mode Sea Spray Aerosol (SSA)

    NASA Astrophysics Data System (ADS)

    Modini, R. L.; Harris, B.; Ristovski, Z. D.

    2009-10-01

    Recent studies have detected a dominant accumulation mode (~100 nm) in the Sea Spray Aerosol (SSA) number distribution. There is evidence to suggest that particles in this mode are composed primarily of organics. To investigate this hypothesis we conducted experiments on NaCl, artificial SSA and natural SSA particles with a Volatility-Hygroscopicity-Tandem-Differential-Mobility-Analyser (VH-TDMA). NaCl particles were atomiser generated and a bubble generator was constructed to produce artificial and natural SSA particles. Natural seawater samples for use in the bubble generator were collected from biologically active, terrestrially-affected coastal water in Moreton Bay, Australia. Differences in the VH-TDMA-measured volatility curves of artificial and natural SSA particles were used to investigate and quantify the organic fraction of natural SSA particles. Hygroscopic Growth Factor (HGF) data, also obtained by the VH-TDMA, were used to confirm the conclusions drawn from the volatility data. Both datasets indicated that the organic fraction of our natural SSA particles evaporated in the VH-TDMA over the temperature range 170-200°C. The organic volume fraction for 71-77 nm natural SSA particles was 8±6%. Organic volume fraction did not vary significantly with varying water residence time (40 s0 to 24 h) in the bubble generator or SSA particle diameter in the range 38-173 nm. At room temperature we measured shape- and Kelvin-corrected HGF at 90% RH of 2.46±0.02 for NaCl, 2.35±0.02 for artifical SSA and 2.26±0.02 for natural SSA particles. Overall, these results suggest that the natural accumulation mode SSA particles produced in these experiments contained only a minor organic fraction, which had little effect on hygroscopic growth. Our measurement of 8±6% is an order of magnitude below two previous measurements of the organic fraction in SSA particles of comparable sizes. Further studies with a variety of different seawaters are required to better quantify how

  19. MELiSSA Food Characterization general approach and current status

    NASA Astrophysics Data System (ADS)

    Weihreter, Martin; Chaerle, Laury; Secco, Benjamin; Molders, Katrien; van der Straeten, Dominique; Duliere, Eric; Pieters, Serge; Maclean, Heather; Dochain, Denis; Quinet, Muriel; Lutts, Stanley; Graham, Thomas; Stasiak, Michael; Rondeau Vuk, Theresa; Zheng, Youbin; Dixon, Mike; Laniau, Martine; Larreture, Alain; Timsit, Michel; Aronne, Giovanna; Barbieri, Giancarlo; Buonomo, Roberta; Veronica; Paradiso, Roberta; de Pascale, Stafania; Galbiati, Massimo; Troia, A. R.; Nobili, Matteo; Bucchieri, Lorenzo; Page, Valérie; Feller, Urs; Lasseur, Christophe

    Higher plants play an important role in closed ecological life support systems as oxygen pro-ducers, carbon dioxide and water recyclers, and as a food source. For an integration of higher plant chambers into the MELiSSA (Micro Ecological Life Support System Alternative) loop, a detailed characterization and optimization of the full food production and preparation chain is needed. This implies the prediction and control of the nutritional quality of the final products consumed by the crew, the prediction of the wastes quality and quantity produced along the chain for further waste treatment (MELiSSA waste treatment) and the optimization of overall efficiencies. To reach this goal several issues have to be studied in an integrated manner: the physiological responses of crops to a range of environmental parameters, crop yield efficiencies and respective ratio and composition of edible and inedible biomass, the processability and storability of the produced food and last but not least composition of wastes in view of further degradation (fiber content). Within the Food Characterization (FC) project several compar-ative plant growth bench tests were carried out to obtain preliminary data regarding these aspects. Four pre-selected cultivars of each of the four energy-rich crops with worldwide usage -wheat, durum wheat, potato and soybean -were grown under well-characterized environmental conditions. The different cultivars of each species are screened for their performance in view of a closed loop application by parameter ranking. This comprises the characterization of edi-ble/inedible biomass ratio, nutritional quality, processability and overall performance under the specific conditions of hydroponic cultivation and artificial illumination. A second closely linked goal of the FC project is to develop a mechanistic physiological plant model, which will ease the integration of higher plants compartments in the MELiSSA concept by virtue of its predictive abilities

  20. Human Decision Processes: Implications for SSA Support Tools

    NASA Astrophysics Data System (ADS)

    Picciano, P.

    2013-09-01

    Despite significant advances in computing power and artificial intelligence (AI), few critical decisions are made without a human decision maker in the loop. Space Situational Awareness (SSA) missions are both critical and complex, typically adhering to the human-in-the-loop (HITL) model. The collection of human operators injects a needed diversity of expert knowledge, experience, and authority required to successfully fulfill SSA tasking. A wealth of literature on human decision making exists citing myriad empirical studies and offering a varied set of prescriptive and descriptive models of judgment and decision making (Hastie & Dawes, 2001; Baron, 2000). Many findings have been proven sufficiently robust to allow information architects or system/interface designers to take action to improve decision processes. For the purpose of discussion, these concepts are bifurcated in two groups: 1) vulnerabilities to mitigate, and 2) capabilities to augment. These vulnerabilities and capabilities refer specifically to the decision process and should not be confused with a shortcoming or skill of a specific human operator. Thus the framing of questions and orders, the automated tools with which to collaborate, priming and contextual data, and the delivery of information all play a critical role in human judgment and choice. Evaluating the merits of any decision can be elusive; in order to constrain this discussion, ‘rational choice' will tend toward the economic model characteristics such as maximizing utility and selection consistency (e.g., if A preferred to B, and B preferred to C, than A should be preferred to C). Simple decision models often encourage one to list the pros and cons of a decision, perhaps use a weighting schema, but one way or another weigh the future benefit (or harm) of making a selection. The result (sought by the rationalist models) should drive toward higher utility. Despite notable differences in researchers' theses (to be discussed in the full

  1. Gap Filling of Precipitation Data by SSA - Singular Spectrum Analysis

    NASA Astrophysics Data System (ADS)

    Filho, A. S. F.; Lima, G. A. R.

    2016-10-01

    From the macroscopic standpoint, the precipitation time series is obtained from observation of natural systems rather than in the laboratory. These time series are often full of gaps (missing values) due to the conditions under which the measurements are made. Missing values give rise to various problems in spectral estimation, inhibit statistical analysis and in specifying boundary conditions for numerical models. Hence, gap filling is necessary in environmental science. The aim of this study is to highlight the application of the SSA forecasting algorithm to fill in missing values to real-life time series. It was applied to several monthly precipitation time series recorded over a large savannah area in Brazil. The results are promising and the accuracy and reliability depend on the pattern and relative length of the gaps with respect to the total length of the time series and presence of noise.

  2. BOREAS RS-12 Automated Ground Sunphotometer Measurements in the SSA

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Lobitz, Brad; Spanner, Michael; Wrigley, Robert

    2000-01-01

    The BOREAS RSS-12 team collected both ground and airborne sunphotometer measurements for use in characterizing the aerosol optical properties of the atmosphere during the BOREAS data collection activities. These measurements are to be used to: 1) measure the magnitude and variability of the aerosol optical depth in both time and space; 2) determine the optical properties of the boreal aerosols; and 3) atmospherically correct some remotely sensed data acquired during BOREAS. These data cover selected days and times from May to September 1994 and were taken from one of two ground sites near Candle Lake in the SSA. The data described in this document are from the field sunphotometer data. The data are stored in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  3. Preliminary study of the space adaptation of the MELiSSA life support system

    NASA Astrophysics Data System (ADS)

    Mas-Albaigès, Joan L.; Duatis, Jordi; Podhajsky, Sandra; Guirado, Víctor; Poughon, Laurent

    MELiSSA (Micro-Ecological Life Support System Alternative) is an European Space Agency (ESA) project focused on the development of a closed regenerative life support system to aid the development of technologies for future life support systems for long term manned planetary missions, e.g. a lunar base or missions to Mars. In order to understand the potential evolution of the MELiSSA concept towards its future use in the referred manned planetary mission context the MELiSSA Space Adaptation (MSA) activity has been undertaken. MSA's main objective is to model the different MELiSSA compartments using EcosimPro R , a specialized simulation tool for life support applications, in order to define a preliminary MELiSSA implementation for service in a man-tended lunar base scenario, with a four-member crew rotating in six-month increments, and performing the basic LSS functions of air revitalization, food production, and waste and water recycling. The MELiSSA EcosimPro R Model features a dedicated library for the different MELiSSA elements (bioreactors, greenhouse, crew, interconnecting elements, etc.). It is used to dimension the MELiSSA system in terms of major parameters like mass, volume and energy needs, evaluate the accuracy of the results and define the strategy for a progressive loop closure from the initial required performance (approx.100 The MELiSSA configuration(s) obtained through the EcosimPro R simulation are further analysed using the Advanced Life Support System Evaluation (ALISSE) metric, relying on mass, energy, efficiency, human risk, system reliability and crew time, for trade-off and optimization of results. The outcome of the MSA activity is, thus, a potential Life Support System architecture description, based on combined MELiSSA and other physico-chemical technologies, defining its expected performance, associated operational conditions and logistic needs.

  4. Anti-SSA/Ro52 autoantibodies in scleroderma: results of an observational, cross-sectional study.

    PubMed

    Sánchez-Montalvá, A; Fernández-Luque, A; Simeón, C P; Fonollosa-Plà, V; Marín, A; Guillén, A; Vilardell, M

    2014-01-01

    To date, the diagnostic utility of anti-SSA/Ro52 autoantibodies in scleroderma and the association of them with certain clinical manifestations, particularly inflammatory myositis, are still controversial. This paper aims to assess the correlation between the presence of anti-SSA/Ro52 antibodies and the demographic, clinical and prognosis characteristics of patients with systemic sclerosis (SSc). This is a retrospective, cross-sectional and observational study in patients with SSc. Baseline demographic and clinical characteristics were recorded. Presence of anti-SSA/Ro52, anti-SSA/Ro, anti-SSB/La, snRNP/Sm, anti-centromere, anti-Scl-70 and anti-PM-Scl were analysed by immunoblot, and antinuclear antibodies (ANA) by indirect immunofluorescence. Statistical analysis was performed with PASW Statics 18 software. A total of 132 consecutive patients with analysis of anti-SSA/Ro52 antibodies were selected from a Spanish cohort of 408 patients with SSc, 87.1% of them being women. About half of patients had the limited form (51.5%), followed by diffused form (18.9%), sclerosis sine scleroderma (22.7%), and pre-scleroderma (6.8%). Prevalence of anti-SSA/Ro52 was 35.6%. No association between anti-SSA/Ro52 and clinical manifestations was found, while detection of anti-SSA/Ro52 was significantly associated with the presence of anti-Ro. The results of our study show that anti-SSA/Ro52 antibodies are often found in SSc patients. No clinical manifestations, including inflammatory myopathy, were related with anti-SSA/Ro antibodies.

  5. 20 CFR 404.410 - How does SSA reduce my benefits when my entitlement begins before full retirement age?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false How does SSA reduce my benefits when my... Nonpayments of Benefits § 404.410 How does SSA reduce my benefits when my entitlement begins before full... in benefits are made in the amounts described. (a) How does SSA reduce my old-age benefits? The...

  6. 20 CFR 404.410 - How does SSA reduce my benefits when my entitlement begins before full retirement age?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false How does SSA reduce my benefits when my... Nonpayments of Benefits § 404.410 How does SSA reduce my benefits when my entitlement begins before full... in benefits are made in the amounts described. (a) How does SSA reduce my old-age benefits? The...

  7. 20 CFR 403.130 - What factors may the Commissioner consider in determining whether SSA will grant your application...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... determining whether SSA will grant your application for testimony? 403.130 Section 403.130 Employees' Benefits... LEGAL PROCEEDINGS § 403.130 What factors may the Commissioner consider in determining whether SSA will grant your application for testimony? In deciding whether to authorize the testimony of an SSA employee...

  8. 20 CFR 403.130 - What factors may the Commissioner consider in determining whether SSA will grant your application...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... determining whether SSA will grant your application for testimony? 403.130 Section 403.130 Employees' Benefits... LEGAL PROCEEDINGS § 403.130 What factors may the Commissioner consider in determining whether SSA will grant your application for testimony? In deciding whether to authorize the testimony of an SSA employee...

  9. 42 CFR 401.132 - Materials in field offices of the Office of Hearings and Appeals, SSA.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Hearings and Appeals, SSA. 401.132 Section 401.132 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Confidentiality and Disclosure § 401.132 Materials in field offices of the Office of Hearings and Appeals, SSA. (a... offices of the Office of Hearings and Appeals, SSA. (1) Title 45 of the Code of Federal Regulations...

  10. 42 CFR 401.132 - Materials in field offices of the Office of Hearings and Appeals, SSA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Hearings and Appeals, SSA. 401.132 Section 401.132 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Confidentiality and Disclosure § 401.132 Materials in field offices of the Office of Hearings and Appeals, SSA. (a... offices of the Office of Hearings and Appeals, SSA. (1) Title 45 of the Code of Federal Regulations...

  11. 20 CFR 404.410 - How does SSA reduce my benefits when my entitlement begins before full retirement age?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false How does SSA reduce my benefits when my... Nonpayments of Benefits § 404.410 How does SSA reduce my benefits when my entitlement begins before full... in benefits are made in the amounts described. (a) How does SSA reduce my old-age benefits? The...

  12. 42 CFR 401.132 - Materials in field offices of the Office of Hearings and Appeals, SSA.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Hearings and Appeals, SSA. 401.132 Section 401.132 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... Confidentiality and Disclosure § 401.132 Materials in field offices of the Office of Hearings and Appeals, SSA. (a... offices of the Office of Hearings and Appeals, SSA. (1) Title 45 of the Code of Federal Regulations...

  13. 20 CFR 404.410 - How does SSA reduce my benefits when my entitlement begins before full retirement age?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How does SSA reduce my benefits when my... Nonpayments of Benefits § 404.410 How does SSA reduce my benefits when my entitlement begins before full... in benefits are made in the amounts described. (a) How does SSA reduce my old-age benefits? The...

  14. Anti-Ro/SSA antibodies in rheumatoid arthritis: clinical and immunologic associations.

    PubMed

    Cavazzana, I; Franceschini, F; Quinzanini, M; Manera, C; Del Papa, N; Maglione, W; Comina, D; Radice, A; Sinico, R A; Cattaneo, R

    2006-01-01

    To assess the prevalence of anti-Ro/SSA in RA and to analyse clinical and serological features of anti-Ro/SSA positive patients with RA. 195 consecutive patients affected by RA were studied by counterimmunoelectrophoresis and ELISA for the detection of anti-Ro/SSA antibodies. Anti-Ro were found in 12 patients, with a prevalence of 6%. These 12 patients were pooled with other 15 patients known to have anti-Ro/SSA antibodies and RA, in order to evaluate their clinical and laboratory features. Anti-Ro positive patients showed a common pattern of joint involvement at onset and a comparable progression of disease compared to anti-Ro negative subjects. In addition, extra-articular manifestations (such as xerophthalmia, xerostomia, scleritis, oral ulcers and amyloidosis) and peculiar autoantibody profile (hypergammaglobulinemia, anti-dsDNA and AMA) were found significantly associated to anti-Ro/SSA positivity. Even though DMARDs withdrawals were more frequently detected in anti-Ro/SSA patients, especially when using gold salts, no statistical difference between the two groups was detected. In addition, anti-TNFalpha treatment did not cause further progression of autoimmunity neither on laboratory nor on clinical ground. Anti-Ro/SSA can be detected in about 6% of patients affected by RA. These patients presented a peculiar clinical picture characterised by extra-articular manifestations some of which are known to be anti-Ro/SSA correlated, while others are more disease-specific (amyloidosis, episcleritis). Anti-Ro/SSA are significantly associated with other autoantibodies not specific for RA such as anti-dsDNA and AMA. Treatment with anti-TNF drugs did not cause further progression of autoimmunity neither on laboratory nor on clinical ground.

  15. SSA’s Journey to SW-CMM ML3 and Transition to CMMI

    DTIC Science & Technology

    2005-01-01

    Patent & Trademark Office. SSA’s Journey to SW-CMM® ML3 and Transition to CMMI® Rick Barbour, SEI Jon Gross, SEI Rod Waltersdorff, Social Security...SSA’s Journey to SW-CMM ML3 and Transition to CMMI 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER...interfaces provided focus in SSA Office of Systems Electronic Services (OSES) and SW- CMM ML3 2004- December Gap analysis demonstrated SSA Office of

  16. BOREAS TGB-10 Oxidant Concentration Data over the SSA

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Conrad, Sara K. (Editor); Westberg, Hal; Hall, Brad; Jackson, Andrea V.

    2000-01-01

    The BOREAS TGB-10 team collected several trace gas data sets in its efforts to determine the role of biogenic hydrocarbon emissions with respect to boreal forest carbon cycles. This data set contains measured peroxide (H2O2 and total organic peroxides (ROOH)) and ozone concentrations as well as H2O2 and ROOH deposition velocities. These data were obtained at the SSA-OJP site from May to September 1994. The data are stored in tabular ASCII files. Some important results were: (1) Ozone concentrations were consistently low, 20-30 ppb, during the summer of 1994. (2) Peroxide concentrations showed a seasonal variation with highest concentrations occurring in July (IFC-2). (3) Midday H2O2 levels averaged around 1.4 ppb during IFC-2 and 0.4 - 0.5 ppb during IFC's 1 and 3. (4) Midday organic peroxide concentrations were lower, averaging 0.8 ppb during IFC-2, and 0.4 - 0.5 ppb during IFC's 1 and 3. (5) The rough pine forest canopy serves as a significant sink for H2O2. (6) Midday H2O2 deposition velocities averaged 4 - 7 cm/s. (7) Organic peroxide deposition velocities (measured as total ROOH) were approximately 40% as large as those of H2O2.

  17. Lyman continuum leaking AGN in the SSA22 field

    NASA Astrophysics Data System (ADS)

    Micheva, Genoveva; Iwata, Ikuru; Inoue, Akio K.

    2017-02-01

    Subaru/SuprimeCam narrow-band photometry of the SSA22 field reveals the presence of four Lyman continuum (LyC) candidates among a sample of 14 active galactic nuclei (AGNs). Two show offsets and likely have stellar LyCin nature or are foreground contaminants. The remaining two LyC candidates are type I AGN. We argue that the average LyC escape fraction of high-redshift, low-luminosity AGN is not likely to be unity, as often assumed in the literature. From direct measurement we obtain the average LyC-to-UV flux density ratio and ionizing emissivity for a number of AGN classes and find it at least a factor of 2 lower than values obtained assuming fesc = 1. Comparing to recent Ly α forest measurements, AGNs at redshift z ˜ 3 make up at most ˜12 per cent and as little as ˜5 per cent of the total ionizing budget. Our results suggest that AGNs are unlikely to dominate the ionization budget of the Universe at high redshifts.

  18. BOREAS TGB-10 Oxidant Flux Data over the SSA

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Conrad, Sara K. (Editor); Westberg, Hal; Hall, Brad; Jackson, Andrea V.

    2000-01-01

    The BOREAS TGB-10 team collected several trace gas data sets in its efforts to determine the role of biogenic hydrocarbon emissions with respect to boreal forest carbon cycles. This oxidant data set contains measured peroxide (H2O2 and total organic peroxides (ROOH)) and ozone concentrations as well as H2O2 and ROOH deposition velocities. These data were obtained at the SSA-OJP site during the summer of 1994. Measurements were made from May to September 1994. The data are stored in tabular ASCII files. Some important results were: (1) Ozone concentrations were consistently low, 20-30 ppb, during the summer of 1994. (2) Peroxide concentrations showed a seasonal variation with highest concentrations occurring in July (IFC-2). (3) Midday H2O2 levels averaged around 1.4 ppb during IFC-2 and 0.4 - 0.5 ppb during IFC's 1 and 3. (4) Midday organic peroxide concentrations were lower, averaging 0.8 ppb during IFC-2, and 0.4 - 0.5 ppb during IFC's 1 and 3. (5) The rough pine forest canopy serves as a significant sink for H2O2. (6) Midday H2O2 deposition velocities averaged 4 - 7 cm/s. (7) Organic peroxide deposition velocities (measured as total ROOH) were approximately 40% as large as those of H2O2.

  19. BOREAS TE-12 Leaf Optical Data for SSA Species

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Curd, Shelaine (Editor); Walter-Shea, Elizabeth A.; Mesarch, Mark A.; Chen, L.

    2000-01-01

    The BOREAS TE-12 team collected several data sets in support of its efforts to characterize and interpret information on the reflectance, transmittance, and gas exchange of boreal vegetation. This data set contains measurements of hemispherical spectral reflectance and transmittance factors of individual leaves, needles (ages: current and past 2 years' growth, i.e., for 1993, the growing seasons of 1993, 1992, and 1991 were measured; in 1994, the growing seasons of 1994, 1993, and 1992 were measured), twigs (reflectance only), and substrate at near-normal incidence measured using a LI-COR LI-1800-12 integrating sphere attached to a Spectron Engineering SE590 spectroradiometer. Procedures of Daughtry et a]. (1989) were followed. These procedures permitted measurement of samples that: (1) filled the entire integrating sphere sample port; and (2) were narrow with a length greater than the sample port diameter. Optical properties were measured in 1993 and 1994 at the SSA Fen, YJP, YA, and OBS sites. The data are stored in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  20. 77 FR 74913 - Privacy Act of 1974, as Amended; Computer Matching Program (Social Security Administration (SSA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-18

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (Social Security Administration (SSA)/Office of Personnel Management (OPM))--Match Number 1307 AGENCY: Social Security Administration....

  1. A New Trend-Following Indicator: Using SSA to Design Trading Rules

    NASA Astrophysics Data System (ADS)

    Leles, Michel Carlo Rodrigues; Mozelli, Leonardo Amaral; Guimarães, Homero Nogueira

    Singular Spectrum Analysis (SSA) is a non-parametric approach that can be used to decompose a time-series as trends, oscillations and noise. Trend-following strategies rely on the principle that financial markets move in trends for an extended period of time. Moving Averages (MAs) are the standard indicator to design such strategies. In this study, SSA is used as an alternative method to enhance trend resolution in comparison with the traditional MA. New trading rules using SSA as indicator are proposed. This paper shows that for the Down Jones Industrial Average (DJIA) and Shangai Securities Composite Index (SSCI) time-series the SSA trading rules provided, in general, better results in comparison to MA trading rules.

  2. A cutoff phenomenon in accelerated stochastic simulations of chemical kinetics via flow averaging (FLAVOR-SSA)

    NASA Astrophysics Data System (ADS)

    Bayati, Basil; Owhadi, Houman; Koumoutsakos, Petros

    2010-12-01

    We present a simple algorithm for the simulation of stiff, discrete-space, continuous-time Markov processes. The algorithm is based on the concept of flow averaging for the integration of stiff ordinary and stochastic differential equations and ultimately leads to a straightforward variation of the the well-known stochastic simulation algorithm (SSA). The speedup that can be achieved by the present algorithm [flow averaging integrator SSA (FLAVOR-SSA)] over the classical SSA comes naturally at the expense of its accuracy. The error of the proposed method exhibits a cutoff phenomenon as a function of its speed-up, allowing for optimal tuning. Two numerical examples from chemical kinetics are provided to illustrate the efficiency of the method.

  3. A cutoff phenomenon in accelerated stochastic simulations of chemical kinetics via flow averaging (FLAVOR-SSA).

    PubMed

    Bayati, Basil; Owhadi, Houman; Koumoutsakos, Petros

    2010-12-28

    We present a simple algorithm for the simulation of stiff, discrete-space, continuous-time Markov processes. The algorithm is based on the concept of flow averaging for the integration of stiff ordinary and stochastic differential equations and ultimately leads to a straightforward variation of the the well-known stochastic simulation algorithm (SSA). The speedup that can be achieved by the present algorithm [flow averaging integrator SSA (FLAVOR-SSA)] over the classical SSA comes naturally at the expense of its accuracy. The error of the proposed method exhibits a cutoff phenomenon as a function of its speed-up, allowing for optimal tuning. Two numerical examples from chemical kinetics are provided to illustrate the efficiency of the method.

  4. BOREAS TF-11 SSA-Fen Soil Surface CO2 Flux Data

    NASA Technical Reports Server (NTRS)

    Arkebauer, Timothy J.; Hall, Forrest G. (Editor); Knapp, David E. (Editor)

    2000-01-01

    The BOREAS TF-11 team gathered a variety of data to complement its tower flux measurements collected at the SSA-Fen site. These data are soil surface CO 2 flux data at the SSA-Fen site from 27- May-1994 to 23-Sep-1994 and from 13-May-1995 to 03-Oct-1995. A portable gas exchange system was used to make these measurements. The data are stored in tabular ASCII files.

  5. Association of anti-Ro/SSA antibody with response to biologics in patients with rheumatoid arthritis.

    PubMed

    Hagiwara, Shinya; Tsuboi, Hiroto; Honda, Fumika; Takahashi, Hidenori; Kurata, Izumi; Ohyama, Ayako; Yagishita, Mizuki; Abe, Saori; Kurashima, Yuko; Kaneko, Syunta; Kawaguchi, Hoshimi; Takahashi, Hiroyuki; Ebe, Hiroshi; Yokosawa, Masahiro; Asashima, Hiromitsu; Hirota, Tomoya; Umeda, Naoto; Kondo, Yuya; Matsumoto, Isao; Sumida, Takayuki

    2016-11-01

    To compare the effectiveness of three different biologics in anti-Ro/SSA antibody-positive and antibody-negative patients with rheumatoid arthritis (RA). The study subjects were 110 biologics naïve patients with RA who started treatment with biologics and examined for anti-Ro/SSA antibody between December 2003 and March 2014. For patients treated with intravenous infliximab (IFX), tocilizumab (TCZ), or abatacept (ABT), we compared the clinical characteristics and changes in composite disease activity index, such as DAS28, SDAI, and CDAI, for 12 months in anti-Ro/SSA antibody-positive and antibody-negative patients. We examined 59 patients (nine were positive and 50 were negative for anti-Ro/SSA antibody) treated with IFX, 27 patients (5 positive and 22 negative) treated with TCZ, and 24 patients (13 positive and 11 negative) treated with ABT. For patients treated with IFX, parameters of disease activity did not change significantly from baseline in anti-Ro/SSA antibody-positive patients, whereas they improved in antibody-negative patients. On the other hand, treatment with TCZ and ABT significantly decreased disease activity, relative to baseline, in both anti-Ro/SSA antibody-positive and antibody-negative patients. Anti-Ro/SSA antibody-positive patients treated with IFX showed higher frequency of HACA and seroconversion of ANA, and lower serum TGF-β levels. Positivity to anti-Ro/SSA in RA seems to confer resistance to IFX via production of HACA and ANA, and low serum TGF-β levels, but not to TCZ and ABT.

  6. [Neonatal lupus and maternofetal transmission of anti-SSA/Ro and anti-SSB/La antibodies].

    PubMed

    Feki, S; Turki, A; Frikha, F; Hachicha, H; Walha, L; Gargouri, A; Bahloul, Z; Masmoudi, H

    2015-02-01

    Neonatal lupus (NL) is a rare syndrome caused by placental transfer of maternal anti-SSA/Ro (60 and 52kDa) or anti-SSB/La antibodies. The aim of this study was to evaluate the clinical and biological profile of NL at the neonatal unit of Sfax, Tunisia, over a 10-year period. Six mother-NB pairs (two sets of twins and two sisters) had positive ANA by transplacental transmission during the study period. The ANA pattern was speckled and the NBs' sera titer was half that of their mothers'. Anti-SSA, anti-Ro52, and anti-SSB were found in 100%, 33%, and 50% of the mothers' sera, respectively. The transmission of anti-SSA was observed in four pregnancies out of six, anti-Ro52 in two pregnancies out of two, and anti-SSB in one pregnancy out of three. The patients' clinical records showed that two NBs had a congenital heart block: one with anti-SSA, whose mother had Sjögren syndrome, and another with anti-SSA, anti-SSB, anti-Ro52, and anti-mitochondrial antibodies (M2 type), whose mother had no diagnosis at the child's birth (cutaneous erythema and positive ANA with the same profile). Cutaneous signs (erythema, petechia) were described in three NBs out of six. The two sets of fraternal twins had cutaneous signs with the same ANA titer and profile (no anti-SSA transmission from their mother with lupus and anti-phospholipid syndrome). The two sisters' (two pregnancies 3 years apart) mother had Sjögren syndrome, one of them had heart block with positive anti-SSA, and the other was asymptomatic with anti-SSA and anti-Ro52. The same mother had a history of three pregnancies with two NBs who died of heart block. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  7. BOREAS TF-1 SSA-OA Weekly Tower CH4 and N2O Flux

    NASA Technical Reports Server (NTRS)

    Thurtell, George; Edwards, Grant; Simpson, George; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOREAS TF-1 team collected various trace gas and energy flux data in its efforts to characterize the temporal energy and gas exchanges that occurred over the SSA-OA site. This data set contains methane (CH4) and nitrous oxide (N2O) fluxes that were measured at the BOREAS SSA-OA site. These fluxes were measured from 16-Apr to 16-Sep-1994. The data were averaged to weekly values and are available in tabular ASCII files.

  8. 20 CFR 403.145 - What will SSA do if you have not satisfied the conditions in this part or in 20 CFR part 401 or 402?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false What will SSA do if you have not satisfied... LEGAL PROCEEDINGS § 403.145 What will SSA do if you have not satisfied the conditions in this part or in... are met, no SSA employee will appear. (c) SSA will seek the advice and assistance of the Department of...

  9. 20 CFR 403.145 - What will SSA do if you have not satisfied the conditions in this part or in 20 CFR part 401 or 402?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false What will SSA do if you have not satisfied... LEGAL PROCEEDINGS § 403.145 What will SSA do if you have not satisfied the conditions in this part or in... are met, no SSA employee will appear. (c) SSA will seek the advice and assistance of the Department of...

  10. 20 CFR 403.145 - What will SSA do if you have not satisfied the conditions in this part or in 20 CFR part 401 or 402?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false What will SSA do if you have not satisfied... LEGAL PROCEEDINGS § 403.145 What will SSA do if you have not satisfied the conditions in this part or in... are met, no SSA employee will appear. (c) SSA will seek the advice and assistance of the Department of...

  11. 20 CFR 403.145 - What will SSA do if you have not satisfied the conditions in this part or in 20 CFR part 401 or 402?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false What will SSA do if you have not satisfied... LEGAL PROCEEDINGS § 403.145 What will SSA do if you have not satisfied the conditions in this part or in... are met, no SSA employee will appear. (c) SSA will seek the advice and assistance of the Department of...

  12. 20 CFR 403.145 - What will SSA do if you have not satisfied the conditions in this part or in 20 CFR part 401 or 402?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false What will SSA do if you have not satisfied... LEGAL PROCEEDINGS § 403.145 What will SSA do if you have not satisfied the conditions in this part or in... are met, no SSA employee will appear. (c) SSA will seek the advice and assistance of the Department of...

  13. High Performance Computing Software Applications Institute for Space Situational Awareness (HSAI-SSA)

    NASA Astrophysics Data System (ADS)

    Sabol, C.; Schumacher, P.; Duncan, B.

    This poster paper firstly provides a status of the Institute project team's work to date over the past year, starting with brief HSAI background from the Department of Defense (DOD) High Performance Computing Modernization Program (DOD HPCMP). HSAI-SSA is one of only nine DOD institute projects that have been selected by the Deputy Under Secretary of Defense (Science and Technology) to focus and use advanced computational science and high performance computing to accelerate solving the DOD's highest priority challenges and make important advances in research, development, test, and evaluation. HSAI-SSA is the only DOD institute project focused on Space. We next describe Space Situational Awareness (SSA), how its many challenges necessitate supercomputing, and identify the type of disciplines required to solve many SSA problems; and the role of the Institute, which is led by the Air Force Research Laboratory AFRL/RD Directorate and an Onsite Director located on Maui. We then follow with a short discussion of the vision, mission, and overview of the Institute's strategic goals and core competencies. HSAI-SSA core competencies include Image Enhancement, Astrodynamics, Non-Resolvable Satellite Characterization, Data Integration, and High Performance Computing. We then follow up with and most of the poster shows and discusses the technical status for several of our current software applications projects and show the high performance computing metrics we have been able to achieve to date. In closing, we quickly summarize HSAI-SSA challenges, members and partners, and technology transition payoffs for selected applications and users.

  14. Hydraulic and mechanical behavior of landfill clay liner containing SSA in contact with leachate.

    PubMed

    Zhang, Qian; Lu, Haijun; Liu, Junzhu; Wang, Weiwei; Zhang, Xiong

    2017-05-24

    Sewage sludge ash (SSA) produced by municipal sludge can be used as a modified additive for clay liner, and improves the working performance of landfill clay liner in contact with leachate. Under the action of landfill leachate, the permeability, shear strength, phase composition, and pore structure of the modified clay are investigated through the flexible wall permeability test, triaxial shear test, thermal gravimetric and differential thermal analysis, and low-temperature nitrogen adsorption test, respectively. The hydraulic conductivity of the modified clay containing 0-5% SSA is in the range of 3.94 × 10(-8)-1.16 × 10(-7) cm/s, and the pollutant concentration of the sample without SSA was higher than others. The shear strength of the modified clay is more than that of the traditional clay liner, the cohesion rate of modified clay increases from 32.5 to 199.91 kPa, and the internal friction angle decreases from 32.5° to 15.6°. Furthermore, the weight loss rates of the samples are 15.69%, 17.92%, 18.06%, and 20.68%, respectively, when the SSA content increases from 0% to 5%. The total pore volume and average pore diameter of the modified clay decrease with the increase in the SSA content, respectively. However, the specific area of the modified clay increases with the increase in the SSA content.

  15. Meet EPA's Dan Nelson

    EPA Pesticide Factsheets

    EPA’s Dan Nelson is the Director of the Human Research Protocol Office at the National Health and Environmental Effect Research Laboratory, Dan works to protect the rights and welfare of EPA’s research participants.

  16. [Detection of anti-SSA/Ro antibody by ELISA, double immunodiffusion, and immunoblotting: a comparative study].

    PubMed

    Tong, Sheng-quan; Shi, Qun; Wen, Xiao-hong; Gan, Xiao-dan; Shi, Yan-ping; Zhao, Yan; Zeng, Xiao-feng; Zhang, Feng-chun; Dong, Yi

    2006-09-19

    To compare the specificity and sensitivity of ELISA, double immunodiffusion (ID), and immunoblotting (IB) in detection of anti-SSA/Ro antibodies in the sera of patients with connective tissue disease (CTD). ELISA, double ID, and IB were used to detect the serum levels of anti-SSA/Ro antibodies in 7736 patients undergoing screening of CTD, 122 healthy blood donors, and 166 CTD patients positive in antinuclear antibody (ANA) and/or anti-extractable nuclear antigen (ENA). (1) The sera of the 122 healthy blood donors were all negative in anti-SSA/Ro antibodies by these three methods. (2) 1085 of the 7736 sera undergoing screening of CTD were positive in the anti-SSA/R0 antibody of the relative molecular quantity of 52,000. Ninety-two of the 1085 patient, ANA and/or anti-ENA negative, were all confirmed by ELISA and ID to be negative in anti-SSA/R0 antibodies. And 993 of these 1085 patients were positive in ANA and/or anti-ENA antibody, 917 of which were shown to be anti-SSA/R0 antibodies positive by ELISA (92.3%, 917/993), and 860 of which were shown to be anti-SSA/R0 antibodies positive by ID (86.6%, 860/993). (3) The prevalence rates of anti-SSA/Ro antibodies in the 166 CTD patients detected by ELISA, ID, and IB respectively were 76.5% (127/166), 65.1% (108/166), and 49.4% (82/166) respectively. (4) 127 of the 166 sera of the CTD group were anti-SSA/Ro antibody positive By ELISA, and 108 of the 166 sera were anti-SSA/R0 antibody positive by ID, with a coincidence rate of ELISA and ID of 88.6% (147/166), and there was a significant difference in positive rate of anti-SSA/Ro antibody between these two methods (P < 0.001). 81 of the 166 CTD sera were anti-SSA/Ro antibody positive with a positive rate of 63.8%. The coincidence rate of ID and IB was 75.9% (126/166) and there was a significant difference in positive rate of anti-SSA/Ro antibody between ID and IB methods too (P < 0.001). (5) Spearman's rank correlation study showed that the correlation coefficient between

  17. The location of a disease-associated polymorphism and genomic structure of the human 52-kDa Ro/SSA locus (SSA1)

    SciTech Connect

    Tsugu, H.; Horowitz, R.; Gibson, N.

    1994-12-01

    Sera from approximately 30% of patients with systemic lupus erythematosus (SLE) contain high titers of autoantibodies that bind to the 52-kDa Ro/SSA protein. We previously detected polymorphisms in the 52-kDa Ro/SSA gene (SSA1) with restriction enzymes, one of which is strongly associated with the presence of SLE (P < 0.0005) in African Americans. A higher disease frequency and more severe forms of the disease are commonly noted among these female patients. To determine the location and nature of this polymorphism, we obtained two clones that span 8.5 kb of the 52-kDa Ro/SSA locus including its upstream regulatory region. Six exons were identified, and their nucleotide sequences plus adjacent noncoding regions were determined. No differences were found between these exons and the coding region of one of the reported cDNAs. The disease-associated polymorphic site suggested by a restriction enzyme map and confirmed by DNA amplification and nucleotide sequencing was present upstream of exon 1. This polymorphism may be a genetic marker for a disease-related variation in the coding region for the protein or in the upstream regulatory region of this gene. Although this RFLP is present in Japanese, it is not associated with lupus in this race. 41 refs., 4 figs., 2 tabs.

  18. The validity of sequence symmetry analysis (SSA) for adverse drug reaction signal detection.

    PubMed

    Wahab, Izyan A; Pratt, Nicole L; Wiese, Michael D; Kalisch, Lisa M; Roughead, Elizabeth E

    2013-05-01

    To determine the validity of sequence symmetry analysis (SSA) method to detect adverse drug reactions from an administrative claims database. Published randomised controlled trials (RCTs) of 19 medicines were identified through search databases, product information (PI) or the US Food and Drug Administration Web site. All adverse events (AEs) in the RCTs and the PI for the medicines were extracted. AEs were considered 'gold standard positive events' if they were reported as being statistically significant events in adequately powered RCTs. The remaining AEs were considered 'gold standard negative events' if the event was not listed as an AE in the PI for that medicine or any other medicine in its class. Indicators of AEs were identified by consensus from two clinical researchers. SSA was run for each medicine-indicator pair using four different time windows: 3, 6, 9 and 12 months. A total of 120 randomised placebo controlled trials were reviewed for the 19 tested medicines. A total of 165 medicine-indicator pairs (44 positive and 121 negative events) were identified and tested by SSA. At the 12-month time window, the sensitivity, specificity, positive and negative predictive values of SSA were 61% (95%CI 0.46-0.74), 93% (95%CI 0.87-0.96), 77% (95%CI 0.61-0.88) and 87% (95%CI 0.80-0.92), respectively. Using a 3-month time window, the SSA had a lower sensitivity (52%). The SSA technique was found to have moderate sensitivity and high specificity for detecting ADRs. These results suggest that SSA is a potential tool for detecting ADRs using administrative claims data that could complement existing pharmacosurveillance methods. Copyright © 2013 John Wiley & Sons, Ltd.

  19. Role of the Cytosolic Heat Shock Protein 70 Ssa5 in the Ciliate Protozoan Tetrahymena thermophila.

    PubMed

    Fukuda, Yasuhiro; Akematsu, Takahiko; Attiq, Rizwan; Tada, Chika; Nakai, Yutaka; Pearlman, Ronald E

    2015-01-01

    Heat shock protein 70 (Hsp70) is a member of a family of conserved chaperone proteins whose function is well investigated in many model organisms. Here we focus on an Hsp70 called Ssa5 in the ciliate protozoan Tetrahymena thermophila, and reveal that its translation is heat inducible as for general Hsps. Moreover, the protein is abundantly expressed in the cytoplasm during sexual reproduction (conjugation) as well as in response to heat-stress. Knocking out of SSA5 (ΔSSA5) does not affect the survival of the cell under heat-stress, likely due to other Hsp70 paralogs compensating for the defect. During conjugation, ΔSSA5 leads to a fertilization defect in which the two pronuclei are in close proximity but never fuse. The unfertilized pronuclei differentiate, resulting in a heterokaryon with developed haploid germline and somatic nuclei. In addition, degeneration of the parental somatic nucleus is not affected. These results suggest a specific involvement of Ssa5 in pronuclear fusion and fertilization. © 2015 The Author(s) Journal of Eukaryotic Microbiology © 2015 International Society of Protistologists.

  20. Long-term prediction of polar motion using a combined SSA and ARMA model

    NASA Astrophysics Data System (ADS)

    Shen, Yi; Guo, Jinyun; Liu, Xin; Kong, Qiaoli; Guo, Linxi; Li, Wang

    2017-09-01

    To meet the need for real-time and high-accuracy predictions of polar motion (PM), the singular spectrum analysis (SSA) and the autoregressive moving average (ARMA) model are combined for short- and long-term PM prediction. According to the SSA results for PM and the SSA prediction algorithm, the principal components of PM were predicted by SSA, and the remaining components were predicted by the ARMA model. In applying this proposed method, multiple sets of PM predictions were made with lead times of two years, based on an IERS 08 C04 series. The observations and predictions of the principal components correlated well, and the SSA + ARMA model effectively predicted the PM. For 360-day lead time predictions, the root-mean-square errors (RMSEs) of PMx and PMy were 20.67 and 20.42 mas, respectively, which were less than the 24.46 and 24.78 mas predicted by IERS Bulletin A. The RMSEs of PMx and PMy in the 720-day lead time predictions were 28.61 and 27.95 mas, respectively.

  1. Anti-Ro/SSA antibodies and cardiac arrhythmias in the adult: facts and hypotheses.

    PubMed

    Lazzerini, P E; Capecchi, P L; Laghi-Pasini, F

    2010-09-01

    It is well established that the passive trans-placental passage of anti-Ro/SSA antibodies from mother to foetus is associated with the risk to develop an uncommon syndrome named neonatal lupus (NLE), where the congenital heart block represents the most severe clinical feature. Recent evidence demonstrated that also adult heart, classically considered invulnerable to the anti-Ro/SSA antibodies, may represent a target of the arrhythmogenicity of these autoantibodies. In particular, the prolongation of the QTc interval appears the most frequent abnormality observed in adults with circulating anti-Ro/SSA antibodies, with some data suggesting an association with an increased risk of ventricular arrhythmias, also life threatening. Moreover, even though the association between anti-Ro/SSA antibodies and conduction disturbances is undoubtedly less evident in adults than in infants, from the accurate dissection of the literature data the possibility arises that sometimes also the adult cardiac conduction tissue may be affected by such antibodies. The exact arrhythmogenic mechanisms involved in foetus/newborns and adults, respectively, have not been completely clarified as yet. However, increasing evidence suggests that anti-Ro/SSA antibodies may trigger rhythm disturbances through an inhibiting cross-reaction with several cardiac ionic channels, particularly the calcium channels (L-type and T-type), but also the potassium channel hERG, whose different expression and involvement in the cardiac electrophysiology during lifespan might account for the occurrence of age-related differences.

  2. Retrieval of snow Specific Surface Area (SSA) from MODIS data in mountainous regions

    NASA Astrophysics Data System (ADS)

    Mary, A.; Dumont, M.; Dedieu, J.-P.; Durand, Y.; Sirguey, P.; Milhem, H.; Mestre, O.; Negi, H. S.; Kokhanovsky, A. A.

    2012-05-01

    This study describes a method to retrieve snow specific surface area (SSA) from satellite radiance reasurements in mountainous terrain. It aims at comparing different retrieval methods and at addressing topographic corrections of reflectance, namely slope and aspect of terrain and multiple reflections on neighbouring slopes. We use an iterative algorithm to compute reflectance from radiance of the MODerate resolution Imaging Spectrometer (MODIS) with a comprehensive correction of local illumination with regards to topography. The retrieved SSA is compared to the results of the snowpack model Crocus, fed by driving data from the SAFRAN meteorological analysis, over a large domain in the French Alps. We compared SSA retrievals with and without topographic or anisotropy correction, and with a spherical or non-spherical snow reflectance model. The topographic correction enables SSA to be retrieved in better agreement with those from SAFRAN-Crocus. The root mean square deviation is 10.0 m2 kg-1 and the bias is -0.6 m2 kg-1, over 3829 pixels representing seven different dates and snow conditions. The standard deviation of MODIS retrieved data, larger than the one of SAFRAN-Crocus estimates, is responsible for half this RMSD. It is due to the topographic classes used by SAFRAN-Crocus. In addition, MODIS retrieved data show SSA gradients with elevation and solar exposition, physically consistent and in good agreement with SAFRAN-Crocus.

  3. Synthesis and crystal structures of a novel layered silicate SSA-1 and its microporous derivatives by topotactic transformation.

    PubMed

    Takahashi, S; Kurita, Y; Ikeda, T; Miyamoto, M; Uemiya, S; Oumi, Y

    2016-10-18

    The synthesis of a novel layered silicate SSA-1 (SSA: silicate synthesized with a quaternary amine) was achieved in the SiO2-H2O-TEAOH (TEAOH: tetraethylammonium hydroxide - as an organic structural directing agent) system. The crystal structure of SSA-1 involved two silicate layers composed of bre [10T]-type CBU (Composite Building Unit) and TEAOH in interlayers. The topotactic transformation of SSA-1 by calcination was examined, resulting in a porous material (PML-1: porous material transformed from a layered silicate) with a 108 m(2) g(-1) BET surface area and 0.035 cm(3) g(-1) pore volume. PML-1 is a siliceous microporous material with silanols in the framework and possesses unique properties, such as hydrophilicity, in spite of all its silica composition. The most reasonable crystal structure of PML-1 was successfully determined on the basis of the crystal structure of SSA-1 by a combination of manual modelling, PXRD pattern simulation, DFT optimization and Rietveld analysis. Additionally, an interlayer expanded siliceous zeolite SSA-1 (IEZ-SSA-1) was also successfully prepared by silylation using trichloro(methyl)silane under acidic conditions. IEZ-SSA-1 showed hydrophilicity or hydrophobicity properties by changing the functional group of the pillar part in the interlayer. Additionally, IEZ-SSA-1 showed a large gas adsorption property (537 m(2) g(-1) and 0.21 cm(3) g(-1)).

  4. The requirements of yeast Hsp70 of SSA family for the ubiquitin-dependent degradation of short-lived and abnormal proteins.

    PubMed

    Lee, Do Hee; Sherman, Michael Y; Goldberg, Alfred L

    2016-06-17

    Cytoplasmic Hsp70s of SSA family, especially Ssa1p, are involved in the degradation of a variety of misfolded proteins in yeast. However the importance of other Ssa proteins in this process is unclear. To clarify the role(s) of individual Ssa proteins in proteolysis, we measured the breakdown of various cell proteins in mutants lacking different Ssa proteins. In mutants lacking Ssa1p and Ssa2p, the proteasomal degradation of short-lived proteins was reduced, which was not restored fully by the over-expression of Ssa1p. By contrast, the degradation of stable cellular proteins did not require Ssa proteins. The degradation of the cytosolic model substrates (Ub-P-β-gal and R-β-gal) and their ubiquitylation were inhibited by the inactivation of Ssa proteins. In addition, Ssa1p and the co-chaperone Ydj1p are indispensable for the intracellular degradation of a mutant secretory protein, Siiyama variant of human antitrypsin. Our findings indicate that both Ssa1p and Ssa2p are essential for the ubiquitin-dependent degradation of short-lived proteins and the requirements of Ssa proteins and the co-chaperones widely vary depending on the conformations and folding status of the substrates. Copyright © 2016 Elsevier Inc. All rights reserved.

  5. RFI suppression in SAR based on filtering interpretation of SSA and fast implementation

    NASA Astrophysics Data System (ADS)

    Wang, Xiaoyu; Yu, Weidong; Qi, Xiangyang; Liu, Yue

    2012-12-01

    Synthetic aperture radar (SAR) has proven to be a powerful remote sensing instrument for underground and obscured object detection. However, SAR echoes are often contaminated by radio frequency interferences (RFI) from multiple broadcasting stations. Essentially, RFI suppression problem is one-dimensional stationary time series denoising problem. This article proposed a novel RFI suppression algorithm based on singular spectral analysis (SSA) from a linear invariant systems perspective. It can be seen that SSA algorithm has an equivalence relation with finite impulse response (FIR) filter banks. Besides, this article first introduce two approximated methods which can remarkably speed up spectral decomposition--Nyström method and Column-Sampling approximation--to obtain the coefficients of above SSA-FIR-filter. Simulation results and imaging results of measured data have proved the efficiency and validity of this algorithm.

  6. An expanded phenotype of maternal SSA/SSB antibody-associated fetal cardiac disease

    PubMed Central

    CUNEO, BETTINA F.; STRASBURGER, JANETTE F.; NIKSCH, ALISA; OVADIA, MARC; WAKAI, RONALD T.

    2010-01-01

    Objectives Conventional manifestations of fetal Sjögren’s antibodies (SSA/SSB) associated cardiac disease include atrio-ventricular block (AVB), transient sinus bradycardia, endocardial fibroelastosis (EFE) and dilated cardiomyopathy. We describe other manifestations of cardiac disease. Methods We describe three fetuses with unique myocardial and conduction system disease. Results One had isolated EFE with subsequent mitral and tricuspid valve chordal avulsion, the second had sinoatrial and infrahissian conduction system disease, and in both, neonatal progression to life threatening disease occurred. The third had sinus node dysfunction and atrial flutter. Conclusion These findings expand the clinical phenotype of maternal SSA/SSB antibody associated fetal cardiac disease. PMID:19330707

  7. Anti-Ro/SSA antibodies and cardiac rhythm disturbances: Present and future perspectives.

    PubMed

    Santos-Pardo, Irene; Villuendas, Roger; Salvador-Corres, Iñaki; Martínez-Morillo, Melania; Olivé, Alejandro; Bayes-Genis, Antoni

    2015-04-01

    Several case reports, small case series, and original research papers have recently suggested that the action of certain auto-antibodies related to connective tissue diseases may be responsible for significant cardiac rhythm disturbances in adults. The relationship between anti-Ro/SSA antibodies and congenital complete atrioventricular block is well recognized in the fetal heart. Herein we review the emerging evidences of the link to increased levels of anti-Ro/SSA antibodies with rhythm disorders of unknown origin in the adult. Confirmation of this distinct etiology may eventually be the basis for new therapies. Copyright © 2014. Published by Elsevier Ireland Ltd.

  8. [The diagnostic value of anti-SSA antibody in primary Sjögren's syndrome].

    PubMed

    Li, Meng-tao; Zhao, Yan; Zheng, Wen-jie; Su, Jin-mei; Wu, Qing-jun; Jiang, Ying; Xu, Dong; Zhang, Wen; Zhang, Feng-chun; Dong, Yi

    2010-05-01

    According to international classification criteria (2002) on Sjögren's syndrome, labial pathology was still considered as a major criterion for diagnosis. Standard labial biopsy was hard to be carried out in China. This study is to evaluate whether the invasive labial biopsy could be replaced by noninvasive detection of serum anti-SSA antibody. 181 Chinese patients with the initial diagnosis of primary Sjögren's syndrome in Peking Union Medical College Hospital (PUMCH) were enrolled in Sjögren's International Collaborative Clinical Alliance (SICCA). All patients received standard labial biopsies (area of salivary gland tissue ≥ 4 mm²) and focal score (FS) of focal lymphatic sialadenitis were confirmed by pathologists from school of stomatology, University California of San Francisco (UCSF). Anti-SSA antibodies in sera of all patients were detected by double immunodiffusion (DID), Western blot in PUMCH and by enzyme-linked immunosorbent assay (ELISA) in central laboratory of SICCA. The correlation between labial pathological findings and serum anti-SSA antibody was studied by chi² test and the concordance was calculated by unweighted Kappa. (1) Bivariate analysis revealed strong associations of FS > 1 with the presence of anti-SSA antibody by DID (83.9% vs 42.0%, P < 0.0001). The accordance between FS and antibody detection by DID was fine with a kappa value of 0.432. However, there were 16.1% false-positive antibody reports and 42.0% false-negative antibody reports. (2) FS > 1 was strongly associated with the presence of anti-SSA antibody by Western blot (83.0% vs 51.7%, P < 0.0001). But the accordance between FS and antibody detection by Western blot was only fair with a kappa value of 0.316. There were 17.0% false-positive antibody reports and 51.7% false-negative antibody reports. (3) FS > 1 was strongly associated with the presence of anti-SSA antibody by ELISA (81.5% vs 38.6%, P < 0.0001). The accordance between FS and antibody detection by ELISA was

  9. Role of electrospun fibre diameter and corresponding specific surface area (SSA) on cell attachment.

    PubMed

    Chen, Ming; Patra, Prabir K; Lovett, Michael L; Kaplan, David L; Bhowmick, Sankha

    2009-06-01

    In order to develop scaffolds for tissue regeneration applications, it is important to develop an understanding of the kinetics of cell attachment as a function of scaffold geometry. In the present study, we investigated how the specific surface area of electrospun scaffolds affected cell attachment and spreading. Number of cells attached to the scaffold was measured by the relative intensity of a metabolic dye (MTS) and cell spreading was analysed for individual cells by measuring the area of projected F-actin cytoskeleton. We varied the fibre diameter to obtain a specific surface area distribution in the range 2.24-18.79 microm(-1). In addition, we had one case where the scaffolds had beads in them and therefore had non-uniform fibres. For each of these different geometries, we varied the cell-seeding density (0.5-1 x 10(5)) and the serum concentration (0-12%) over the first 8 h in an electrospun polycaprolactone NIH 3T3 fibroblast system. Cells on beaded scaffolds showed the lowest attachment and almost no F-actin spreading in all experiments indicating uniform fibre diameter is essential for electrospun scaffolds. For the uniform fibre scaffolds, cell attachment was a function of scaffold specific surface area (SSA) (18.79-2.24 microm(-1)) and followed two distinct trends: when scaffold SSA was < 7.13 microm(-1), cell adhesion rate remained largely unchanged; however, for SSA > 7.13 microm(-1) there was a significant increase in cellular attachment rate with increasing SSA. This indicated that nanofibrous scaffolds increased cellular adhesion compared to microfibrous scaffolds. This phenomenon is true for serum concentrations of 7.5% and higher. For 5% and lower serum concentration, cell attachment is low and higher SSA fails to make a significant improvement in cell attachment. When cell attachment was investigated at a single-cell level by measuring the projected actin area, a similar trend was noted where the effect of higher SSA led to higher projected area

  10. BOREAS TE-1 Soils Data Over The SSA Tower Sites in Raster Format

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Anderson, Darwin; Knapp, David E.

    2000-01-01

    The BOREAS TE-1 team collected various data to characterize the soil-plant systems in the BOREAS SSA. This data set was gridded from vector layers of soil maps that were received from Dr. Darwin Anderson (TE-1), who did the original soil mapping in the field during 1994. The vector layers were gridded into raster files that cover approximately 1 square kilometer over each of the tower sites in the SSA. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  11. 76 FR 12398 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Bureau of the Public Debt (BPD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY...))--Match Number 1304 AGENCY: Social Security Administration (SSA) . ACTION: Notice of a renewal of an... of the Social Security Act (42 U.S.C. 1395w-114) requires the Commissioner of SSA to verify the...

  12. 75 FR 54213 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Office of Personnel Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ...] [FR Doc No: 2010-22000] SOCIAL SECURITY ADMINISTRATION [Docket No. SSA 2010-0016] Privacy Act of 1974..., 1019, 1020, and 1021 AGENCY: Social Security Administration (SSA). ACTION: Notice of a renewal of an...) and (f) of the Social Security Act (Act) (42 U.S.C. 1383(e)(1)(B) and (f)) and for the SVB purposes...

  13. The Relationship of the Lipoprotein SsaB, Manganese, and Superoxide Dismutase in Streptococcus sanguinis Virulence for Endocarditis

    PubMed Central

    Crump, Katie E.; Bainbridge, Brian; Brusko, Sarah; Turner, Lauren S.; Ge, Xiuchun; Stone, Victoria; Xu, Ping; Kitten, Todd

    2014-01-01

    Summary Streptococcus sanguinis colonizes teeth and is an important cause of infective endocarditis. Our prior work showed that the lipoprotein SsaB is critical for S. sanguinis virulence for endocarditis and belongs to the LraI family of conserved metal transporters. In this study, we demonstrated that an ssaB mutant accumulates less manganese and iron than its parent. A mutant lacking the manganese-dependent superoxide dismutase, SodA, was significantly less virulent than wild-type in a rabbit model of endocarditis, but significantly more virulent than the ssaB mutant. Neither the ssaB nor the sodA mutation affected sensitivity to phagocytic killing or efficiency of heart valve colonization. Animal virulence results for all strains could be reproduced by growing bacteria in serum under physiological levels of O2. SodA activity was reduced, but not eliminated in the ssaB mutant in serum and in rabbits. Growth of the ssaB mutant in serum was restored upon addition of Mn2+ or removal of O2. Antioxidant supplementation experiments suggested that superoxide and hydroxyl radicals were together responsible for the ssaB mutant’s growth defect. We conclude that manganese accumulation mediated by the SsaB transport system imparts virulence by enabling cell growth in oxygen through SodA-dependent and independent mechanisms. PMID:24750294

  14. The relationship of the lipoprotein SsaB, manganese and superoxide dismutase in Streptococcus sanguinis virulence for endocarditis.

    PubMed

    Crump, Katie E; Bainbridge, Brian; Brusko, Sarah; Turner, Lauren S; Ge, Xiuchun; Stone, Victoria; Xu, Ping; Kitten, Todd

    2014-06-01

    Streptococcus sanguinis colonizes teeth and is an important cause of infective endocarditis. Our prior work showed that the lipoprotein SsaB is critical for S. sanguinis virulence for endocarditis and belongs to the LraI family of conserved metal transporters. In this study, we demonstrated that an ssaB mutant accumulates less manganese and iron than its parent. A mutant lacking the manganese-dependent superoxide dismutase, SodA, was significantly less virulent than wild-type in a rabbit model of endocarditis, but significantly more virulent than the ssaB mutant. Neither the ssaB nor the sodA mutation affected sensitivity to phagocytic killing or efficiency of heart valve colonization. Animal virulence results for all strains could be reproduced by growing bacteria in serum under physiological levels of O(2). SodA activity was reduced, but not eliminated in the ssaB mutant in serum and in rabbits. Growth of the ssaB mutant in serum was restored upon addition of Mn(2+) or removal of O(2). Antioxidant supplementation experiments suggested that superoxide and hydroxyl radicals were together responsible for the ssaB mutant's growth defect. We conclude that manganese accumulation mediated by the SsaB transport system imparts virulence by enabling cell growth in oxygen through SodA-dependent and independent mechanisms.

  15. 20 CFR 422.705 - When SSA employees may listen-in to or record telephone conversations.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... telephone conversations. 422.705 Section 422.705 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... telephone conversations. SSA employees may listen-in to or record telephone conversations on SSA telephone lines under the following conditions: (a) Law enforcement/national security. When performed for...

  16. 20 CFR 422.705 - When SSA employees may listen-in to or record telephone conversations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... telephone conversations. 422.705 Section 422.705 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... telephone conversations. SSA employees may listen-in to or record telephone conversations on SSA telephone lines under the following conditions: (a) Law enforcement/national security. When performed for...

  17. 20 CFR 422.705 - When SSA employees may listen-in to or record telephone conversations.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... telephone conversations. 422.705 Section 422.705 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... telephone conversations. SSA employees may listen-in to or record telephone conversations on SSA telephone lines under the following conditions: (a) Law enforcement/national security. When performed for...

  18. 20 CFR 422.705 - When SSA employees may listen-in to or record telephone conversations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... telephone conversations. 422.705 Section 422.705 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... telephone conversations. SSA employees may listen-in to or record telephone conversations on SSA telephone lines under the following conditions: (a) Law enforcement/national security. When performed for...

  19. 77 FR 27108 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Office of Child Support...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-08

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Office of Child Support Enforcement (OCSE))--Match Number 1074 AGENCY: Social Security Administration (SSA). ACTION: Notice of a...

  20. 76 FR 71417 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Law Enforcement Agencies (LEA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Law Enforcement Agencies (LEA... General Counsel. Notice of Computer Matching Program, SSA With the Law Enforcement Agency (LEA) A... establish terms, conditions, and safeguards under which we will conduct a computer matching program with law...

  1. 76 FR 77238 - Submission for OMB Review; Comment Request; The SSA-NIH Collaboration to Improve the Disability...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-12

    ... HUMAN SERVICES National Institutes of Health Submission for OMB Review; Comment Request; The SSA-NIH... allow the SSA to collect more relevant and precise data about human functioning in a faster, more... functional domains of Physical Demands and Interpersonal Interactions along with established...

  2. 76 FR 55690 - Submission for OMB Review; Comment Request; The SSA-NIH Collaboration To Improve the Disability...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-08

    ... HUMAN SERVICES National Institutes of Health Submission for OMB Review; Comment Request; The SSA-NIH... could potentially allow the SSA to collect more relevant and precise data about human functioning in a... tools for the functional domains of Physical Demands and Interpersonal Interactions along...

  3. 78 FR 69926 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Centers for Medicare & Medicaid...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-21

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Centers for Medicare & Medicaid Services (CMS))--Match Number 1076 AGENCY: Social Security Administration (SSA). ACTION: Notice of...

  4. 76 FR 5235 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA Internal Match)-Match Number 1014

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-28

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA Internal Match)--Match Number 1014 AGENCY: Social Security Administration (SSA) ACTION: Notice of a new computer matching program. SUMMARY... computer matching program that we are conducting with ourselves. DATES: We will file a report of the...

  5. 77 FR 6620 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/the States); Match 6000 and 6003

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ the States); Match 6000 and 6003 AGENCY: Social Security Administration (SSA). ACTION: Notice of a renewal of an existing computer... Privacy Act, as amended, this notice announces a renewal of an existing computer matching program that we...

  6. 78 FR 40541 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA)-Match Number 1014

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-05

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA)--Match Number 1014 AGENCY: Social Security Administration (SSA). ] ACTION: Notice of a renewal of an existing computer matching program that... amended, this notice announces a renewal of an existing computer matching program that we are currently...

  7. 77 FR 24757 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Department of Labor (DOL))-Match...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Department of Labor (DOL))--Match Number 1015 AGENCY: Social Security Administration (SSA). ACTION: Notice of a new computer matching... a new computer matching program that we will conduct with DOL. Also published today in a separate...

  8. 20 CFR 404.522 - Review within SSA that an overpayment is past due and legally enforceable.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Review within SSA that an overpayment is past due and legally enforceable. 404.522 Section 404.522 Employees' Benefits SOCIAL SECURITY... within SSA that an overpayment is past due and legally enforceable. (a) Notification by overpaid...

  9. 20 CFR 416.582 - Review within SSA that an overpayment is past due and legally enforceable.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Review within SSA that an overpayment is past due and legally enforceable. 416.582 Section 416.582 Employees' Benefits SOCIAL SECURITY..., and Underpayments § 416.582 Review within SSA that an overpayment is past due and legally enforceable...

  10. 20 CFR 404.522 - Review within SSA that an overpayment is past due and legally enforceable.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Review within SSA that an overpayment is past due and legally enforceable. 404.522 Section 404.522 Employees' Benefits SOCIAL SECURITY... within SSA that an overpayment is past due and legally enforceable. (a) Notification by overpaid...

  11. 20 CFR 403.125 - How will we handle requests for records, information, or testimony involving SSA's Office of the...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false How will we handle requests for records, information, or testimony involving SSA's Office of the Inspector General? 403.125 Section 403.125 Employees... involving SSA's Office of the Inspector General? A request for records or information of the Office of the...

  12. 20 CFR 403.125 - How will we handle requests for records, information, or testimony involving SSA's Office of the...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false How will we handle requests for records, information, or testimony involving SSA's Office of the Inspector General? 403.125 Section 403.125 Employees... involving SSA's Office of the Inspector General? A request for records or information of the Office of the...

  13. 20 CFR 403.125 - How will we handle requests for records, information, or testimony involving SSA's Office of the...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false How will we handle requests for records, information, or testimony involving SSA's Office of the Inspector General? 403.125 Section 403.125 Employees... involving SSA's Office of the Inspector General? A request for records or information of the Office of the...

  14. 20 CFR 416.582 - Review within SSA that an overpayment is past due and legally enforceable.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Review within SSA that an overpayment is past due and legally enforceable. 416.582 Section 416.582 Employees' Benefits SOCIAL SECURITY..., and Underpayments § 416.582 Review within SSA that an overpayment is past due and legally enforceable...

  15. 20 CFR 411.597 - Will SSA periodically review the outcome payment system and the outcome-milestone payment system...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Will SSA periodically review the outcome payment system and the outcome-milestone payment system for possible modifications? 411.597 Section 411... Employment Network Payment Systems § 411.597 Will SSA periodically review the outcome payment system and the...

  16. 20 CFR 404.522 - Review within SSA that an overpayment is past due and legally enforceable.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Review within SSA that an overpayment is past due and legally enforceable. 404.522 Section 404.522 Employees' Benefits SOCIAL SECURITY... within SSA that an overpayment is past due and legally enforceable. (a) Notification by overpaid...

  17. 20 CFR 411.597 - Will SSA periodically review the outcome payment system and the outcome-milestone payment system...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Will SSA periodically review the outcome payment system and the outcome-milestone payment system for possible modifications? 411.597 Section 411... Employment Network Payment Systems § 411.597 Will SSA periodically review the outcome payment system and the...

  18. 20 CFR 403.125 - How will we handle requests for records, information, or testimony involving SSA's Office of the...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false How will we handle requests for records, information, or testimony involving SSA's Office of the Inspector General? 403.125 Section 403.125 Employees... involving SSA's Office of the Inspector General? A request for records or information of the Office of the...

  19. 20 CFR 416.582 - Review within SSA that an overpayment is past due and legally enforceable.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Review within SSA that an overpayment is past due and legally enforceable. 416.582 Section 416.582 Employees' Benefits SOCIAL SECURITY..., and Underpayments § 416.582 Review within SSA that an overpayment is past due and legally enforceable...

  20. 20 CFR 404.522 - Review within SSA that an overpayment is past due and legally enforceable.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Review within SSA that an overpayment is past due and legally enforceable. 404.522 Section 404.522 Employees' Benefits SOCIAL SECURITY... within SSA that an overpayment is past due and legally enforceable. (a) Notification by overpaid...

  1. 20 CFR 403.125 - How will we handle requests for records, information, or testimony involving SSA's Office of the...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false How will we handle requests for records, information, or testimony involving SSA's Office of the Inspector General? 403.125 Section 403.125 Employees... involving SSA's Office of the Inspector General? A request for records or information of the Office of the...

  2. 20 CFR 411.597 - Will SSA periodically review the outcome payment system and the outcome-milestone payment system...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Will SSA periodically review the outcome payment system and the outcome-milestone payment system for possible modifications? 411.597 Section 411... Employment Network Payment Systems § 411.597 Will SSA periodically review the outcome payment system and the...

  3. 20 CFR 416.582 - Review within SSA that an overpayment is past due and legally enforceable.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Review within SSA that an overpayment is past due and legally enforceable. 416.582 Section 416.582 Employees' Benefits SOCIAL SECURITY..., and Underpayments § 416.582 Review within SSA that an overpayment is past due and legally enforceable...

  4. 20 CFR 404.522 - Review within SSA that an overpayment is past due and legally enforceable.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Review within SSA that an overpayment is past due and legally enforceable. 404.522 Section 404.522 Employees' Benefits SOCIAL SECURITY... within SSA that an overpayment is past due and legally enforceable. (a) Notification by overpaid...

  5. 76 FR 21091 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Centers for Medicare & Medicaid...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... From the Federal Register Online via the Government Publishing Office ] SOCIAL SECURITY ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Centers for Medicare & Medicaid Services (CMS))--Match Number 1076 AGENCY: Social Security Administration (SSA). ACTION: Notice of a...

  6. Mechanical behavior of mortars containing sewage sludge ash (SSA) and Portland cements with different tricalcium aluminate content

    SciTech Connect

    Monzo, J.; Paya, J.; Borrachero, M.V.; Peris-Mora, E.

    1999-01-01

    The influence of sewage sludge ash (SSA) on cement mortars strength has been studied. To evaluate better the increase of strength compared to control mortar, relative compressive strength gain (CSGr) and flexural strength gain (FSGr) were calculated. The experience shows that SSA behaves as an active material, producing an increase of compressive strength compared to control mortar, probably due to pozzolanic properties of SSA. It can be emphasized that high sulfur content of SSA (12.4%) does not seem to have influence on compressive strength of mortars containing SSA. When CSGr of mortars containing different types of cements are compared, no clear correlation is observed between CSGr and C{sub 3}A content in cement.

  7. BOREAS TF-9 SSA-OBS Tower Flux, Meteorological, and Soil Temperature Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Massheder, Jonathan M.; Moncrieff, John B.; Rayment, Mark B.; Jarvis, Paul G.

    2000-01-01

    The BOREAS TF-9 team collected energy, carbon dioxide, and water vapor flux data at the BOREAS SSA-OBS site during the growing season of 1994 and most of the year for 1996. From the winter of 1995 to 1996, soil temperature data were also collected and provided. The data are available in tabular ASCII files.

  8. BOREAS TF-7 SSA-OBS Tower Flux and Meteorological Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Pattey, Elizabeth; Desjardins, Raymond L.

    2000-01-01

    The BOREAS TF-7 team collected meteorological data as well as energy, carbon dioxide, water vapor, methane, and nitrous oxide flux data at the BOREAS SSA-OBS site. The data were collected from 24-May to 19-Sep-1994. The data are available in tabular ASCII files.

  9. Get in the Loop: Fibre Channel, SSA, and Ultra SCSI Connect the Digital Studio.

    ERIC Educational Resources Information Center

    Sauer, Jeff

    1997-01-01

    Removable hard drives and Ethernet are common ways to move data around the media studio, but new protocols allow multiple computers to share an array on one bus. Examines shared storage configurations using fibre channel arbitrated loop (FC-AL) and serial storage architecture (SSA), both serial storage solutions, as well as on small computer…

  10. 20 CFR 429.110 - Are there any limitations on SSA's authority under this subpart?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Are there any limitations on SSA's authority under this subpart? 429.110 Section 429.110 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... Justice when it is learned that the United States, or an employee, agent, or cost-plus contractor of the...

  11. SERM Forest Cover Data Layers of the SSA in Vector Format

    NASA Technical Reports Server (NTRS)

    Nickeson, Jaime; Gruszka, Fern; Hall, Forrest G. (Editor)

    2000-01-01

    This data set was prepared by the SERM-FBIU. The data include information on forest parameters and cover the area in and near the BOREAS SSA, excluding the PANP. The data were produced from aerial photography taken as recently as 1988.

  12. 20 CFR 411.250 - How will SSA evaluate a PM?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... PROGRAM Use of One or More Program Managers To Assist in Administration of the Ticket to Work Program Evaluation of Program Manager Performance § 411.250 How will SSA evaluate a PM? (a) We will periodically conduct a formal evaluation of the PM. The evaluation will include, but not be limited to, an...

  13. 20 CFR 411.250 - How will SSA evaluate a PM?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... PROGRAM Use of One or More Program Managers To Assist in Administration of the Ticket to Work Program Evaluation of Program Manager Performance § 411.250 How will SSA evaluate a PM? (a) We will periodically conduct a formal evaluation of the PM. The evaluation will include, but not be limited to, an...

  14. 20 CFR 411.250 - How will SSA evaluate a PM?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... PROGRAM Use of One or More Program Managers To Assist in Administration of the Ticket to Work Program Evaluation of Program Manager Performance § 411.250 How will SSA evaluate a PM? (a) We will periodically conduct a formal evaluation of the PM. The evaluation will include, but not be limited to, an...

  15. 20 CFR 411.250 - How will SSA evaluate a PM?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... PROGRAM Use of One or More Program Managers To Assist in Administration of the Ticket to Work Program Evaluation of Program Manager Performance § 411.250 How will SSA evaluate a PM? (a) We will periodically conduct a formal evaluation of the PM. The evaluation will include, but not be limited to, an...

  16. BOREAS TF-1 SSA-OA Tower Flux, Meteorological, and Soil Temperature Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Black, T. Andrew; Chen, Z.; Nesic, Zoran

    2000-01-01

    The BOREAS TF-1 team collected energy, carbon dioxide, and momentum flux data above the canopy along with meteorological and soils data at the BOREAS SSA-OA site from mid-April to the end of the year for 1996. The data are available in tabular ASCII files.

  17. BOREAS TF-1 SSA-OA Understory Flux, Meteorological, and Soil Temperature Data

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Black, T. Andrew; Chen, Z.; Nesic, Zoran

    2000-01-01

    The BOREAS TF-1 team collected energy, carbon dioxide, and momentum flux data under the canopy along with meteorological and soils data at the BOREAS SSA-OA site from mid-October to mid-November of 1993 and throughout all of 1994. The data are available in tabular ASCII files.

  18. Possible role of anti-SSA/Ro antibodies in the pathogenesis of pulmonary hypertension

    PubMed Central

    Guerreso, Kelsey; Conner, Edward Alexander

    2016-01-01

    Introduction There are many different causes of pulmonary hypertension and the pathogenesis of the disease is still being elucidated. Although they are not the most common, autoimmunity and inflammation have been identified as possible causes. No one autoantibody has been identified as the definite cause of pulmonary hypertension. We present a rare association of anti-SSA/Ro antibodies and isolated pulmonary hypertension. Case presentation A 53 year old African American female presented with abdominal pain, nausea, weight loss, dyspnea and fatigue. Upon further exam she was found to have high titers of antinuclear antibodies and anti-SSA/Ro antibodies. This antibody profile would typically be suggestive of Sjögren's Syndrome, which is characterized by dry eyes and poor salivary gland function. However, since this patient did not have any symptoms consistent with the disease a diagnosis of Sjögren's Syndrome could not be made. A combination of laboratory, imaging and diagnostic studies were done that revealed a final diagnosis of pulmonary hypertension. Conclusion It is known that pulmonary hypertension has association with autoimmune diseases, however no clear markers yet exist. Anti-SSA/Ro antibodies have been rarely described in cases of pulmonary disease, and less so in pulmonary hypertension. This case describes a unique association between isolated pulmonary hypertension and anti-SSA/Ro antibody, thereby illustrating the need to investigate this autoantibody and others in the pathogenesis of autoimmune pulmonary hypertension. PMID:27222785

  19. BOREAS TF-6 SSA-YA Surface Energy Flux and Meteorological Data

    NASA Technical Reports Server (NTRS)

    Bessemoulin, Pierre; Puech, Dominique; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOREAS TF-6 team collected surface energy flux and meteorology data at the SSA-YA site. The data characterize the energy flux and meteorological conditions at the site from 18-Jul to 20-Sep-1994. The data set does not contain any trace gas exchange measurements. The data are available in tabular ASCII files.

  20. BOREAS TF-4 SSA-YJP Tower Flux, Meteorological, and Canopy Condition Data

    NASA Technical Reports Server (NTRS)

    Striegl, Robert; Wickland, Kimberly; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-4) team collected energy, carbon dioxide, and water vapor flux data at the BOREAS Southern Study Area-Young Jack Pine (SSA-YJP) site during the growing season of 1994. In addition, meteorological data were collected both above and within the canopy. The data are available in tabular ASCII files.

  1. ESA research and development activity on SSA-NEO preliminary definition

    NASA Astrophysics Data System (ADS)

    Franco, R.

    2010-10-01

    The paper gives an account of goals, prospects, and planning of the first ESA research associated with definition of the SSA-NEO segment and puts it in the context of ESA system engineering practices of ESA (as defined in ESA’s ECSS standards).

  2. Mapping of HI Absorption Structure in the SSA22 Protocluster at z = 3.1

    NASA Astrophysics Data System (ADS)

    Mawatari, Ken

    2017-07-01

    We developed a new scheme to evaluate z = 3.1 HI Lya absorption strength relative to the cosmic mean from photometric data of star-forming galaxies at z = 3.3 - 3.5. With the new measure, dNB497, we have made two dimensional HI absorption maps in the z = 3.1 SSA22 proto-cluster region and two control fields with a spatial resolution of 5 comoving Mpc. The HI absorption strength in the SSA22 field are systematically larger than those in the control fields, and this HI absorption enhancement extends more than 50 comoving Mpc. The field-averaged (i.e., 50 comoving Mpc scale) HI absorption strength and the overdensity of Lya emitters (LAEs) seem to be correlated, while there is no clear dependency of the HI absorption strength on the local LAE overdensity in a few comoving Mpc scale. These results suggest that diffuse HI gas spreads out in/around the SSA22 proto-cluster. We have also found an enhancement of HI absorption at a projected distance less than 100 physical kpc from the nearest z = 3.1 galaxies at least in the SSA22 field, which is probably due to HI gas associated with the CGM of individual galaxies.

  3. BOREAS TF-5 SSA-OJP Tower Flux and Meteorological Data

    NASA Technical Reports Server (NTRS)

    Baldocchi, Dennis; Vogel, Christoph; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-5) team collected tower flux data at the BOREAS Southern Study Area Old Jack Pine (SSA-OJP) site through the growing season of 1994. The data are available in tabular ASCII files.

  4. ESA SSA Space Radiation Expert Service Centre: the Importance of Community Feedback

    NASA Astrophysics Data System (ADS)

    Crosby, Norma; Dierckxsens, Mark; Kruglanski, Michel; De Donder, Erwin; Calders, Stijn; Messios, Neophytos; Glover, Alexi

    2017-04-01

    End-users in a wide range of sectors both in space and on the ground are affected by space weather. In the frame of its Space Situational Awareness (SSA) programme (http://swe.ssa.esa.int/) the European Space Agency (ESA) is establishing a Space Weather (SWE) Service Network to support end-users in three ways: mitigate the effects of space weather on their systems, reduce costs, and improve reliability. Almost 40 expert groups from institutes and organisations across Europe contribute to this Network organised in five Expert Service Centres (ESCs) - Solar Weather, Heliospheric Weather, Space Radiation, Ionospheric Weather, Geomagnetic Conditions. To understand the end-user needs, the ESCs are supported by the SSCC (SSA Space Weather Coordination Centre) that offers first line support to the end-users. Here we present the mission of the Space Radiation ESC (R-ESC) (http://swe.ssa.esa.int/space-radiation) and the space domain services it supports. Furthermore, we describe how the R-ESC project complements past and ongoing projects both on national level as well as international (e.g. EU projects), emphasizing the importance of inter-disciplinary communication between different communities ranging from scientists, engineers to end-users. Such collaboration is needed if basic science is to be used most efficiently for the development of products and tools that provide end-users with what they actually need. Additionally, feedback from the various communities (projects) is also essential when defining future projects.

  5. Application of magnetically modified sewage sludge ash (SSA) in ionic dye adsorption.

    PubMed

    Hu, Shao-Hua; Hu, Shen-Chih

    2014-02-01

    Incineration is a traditional method of treating sewage sludge and the disposal of derived ash is a problem of secondary waste treatment. In this study, sewage sludge ash (SSA) was coated with ferrite through a ferrite process and then used as an adsorbent for ionic dyes (methylene blue [MB] and Procion Red MX-5B [PR]). The modified SSA possessed surface potential that provided electrostatic attraction toward MB and PR. Adsorbent FA10 (named on the basis of being produced from 10 g of SSA in the ferrite process) was used for the adsorption of MB. Ideal pH for adsorption was 9.0 and maximum adsorption capacity based on Langmuir isotherm equation was 22.03 mg/g. Adsorbent FA2.5 (named on the basis of being produced from 2.5 g of SSA in the ferrite process) was used for PR adsorption. Ideal pH for adsorption was 3.0 and the maximum adsorption capacity (calculated as above) was 28.82 mg/g. Kinetic results reveal that both MB and PR adsorption fit the pseudo-second-order kinetic model better than the pseudo-first-order model. The values of activation energy calculated from rate constants were 61.71 and 9.07 kJ/mol for MB and PR, respectively.

  6. Possible role of anti-SSA/Ro antibodies in the pathogenesis of pulmonary hypertension.

    PubMed

    Guerreso, Kelsey; Conner, Edward Alexander

    2016-01-01

    There are many different causes of pulmonary hypertension and the pathogenesis of the disease is still being elucidated. Although they are not the most common, autoimmunity and inflammation have been identified as possible causes. No one autoantibody has been identified as the definite cause of pulmonary hypertension. We present a rare association of anti-SSA/Ro antibodies and isolated pulmonary hypertension. A 53 year old African American female presented with abdominal pain, nausea, weight loss, dyspnea and fatigue. Upon further exam she was found to have high titers of antinuclear antibodies and anti-SSA/Ro antibodies. This antibody profile would typically be suggestive of Sjögren's Syndrome, which is characterized by dry eyes and poor salivary gland function. However, since this patient did not have any symptoms consistent with the disease a diagnosis of Sjögren's Syndrome could not be made. A combination of laboratory, imaging and diagnostic studies were done that revealed a final diagnosis of pulmonary hypertension. It is known that pulmonary hypertension has association with autoimmune diseases, however no clear markers yet exist. Anti-SSA/Ro antibodies have been rarely described in cases of pulmonary disease, and less so in pulmonary hypertension. This case describes a unique association between isolated pulmonary hypertension and anti-SSA/Ro antibody, thereby illustrating the need to investigate this autoantibody and others in the pathogenesis of autoimmune pulmonary hypertension.

  7. 20 CFR 411.330 - How will SSA evaluate an EN's performance?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false How will SSA evaluate an EN's performance? 411.330 Section 411.330 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF... periodically review the results of the work of each EN to ensure effective quality assurance in the provision...

  8. 20 CFR 411.330 - How will SSA evaluate an EN's performance?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false How will SSA evaluate an EN's performance? 411.330 Section 411.330 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF... periodically review the results of the work of each EN to ensure effective quality assurance in the provision...

  9. 20 CFR 429.110 - Are there any limitations on SSA's authority under this subpart?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... under this subpart? 429.110 Section 429.110 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... with the Department of Justice when, in the opinion of SSA: (1) A new precedent or a new point of law... Justice when it is learned that the United States, or an employee, agent, or cost-plus contractor of...

  10. 20 CFR 429.110 - Are there any limitations on SSA's authority under this subpart?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... under this subpart? 429.110 Section 429.110 Employees' Benefits SOCIAL SECURITY ADMINISTRATION... with the Department of Justice when, in the opinion of SSA: (1) A new precedent or a new point of law... Justice when it is learned that the United States, or an employee, agent, or cost-plus contractor of...

  11. Get in the Loop: Fibre Channel, SSA, and Ultra SCSI Connect the Digital Studio.

    ERIC Educational Resources Information Center

    Sauer, Jeff

    1997-01-01

    Removable hard drives and Ethernet are common ways to move data around the media studio, but new protocols allow multiple computers to share an array on one bus. Examines shared storage configurations using fibre channel arbitrated loop (FC-AL) and serial storage architecture (SSA), both serial storage solutions, as well as on small computer…

  12. 20 CFR 411.250 - How will SSA evaluate a PM?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PROGRAM Use of One or More Program Managers To Assist in Administration of the Ticket to Work Program Evaluation of Program Manager Performance § 411.250 How will SSA evaluate a PM? (a) We will periodically conduct a formal evaluation of the PM. The evaluation will include, but not be limited to, an...

  13. Ro/SSA autoantibody-positive pregnancy: reactions to serial fetal Doppler echocardiographic surveillance.

    PubMed

    Tingström, J; Hjelmstedt, A; Welin Henriksson, E; Sonesson, S-E; Wahren-Herlenius, M

    2015-12-01

    The risk for congenital heart block (CHB) associated with maternal Ro/SSA autoantibodies is low, but the possibility of treating early stages of disease has seen the introduction of Doppler echocardiographic surveillance programs with serial examinations during the CHB susceptibility weeks of pregnancy. The aim of the present study was to understand how Ro/SSA autoantibody-positive women having undergone Doppler echocardiographic surveillance programs and giving birth to children without CHB experienced their pregnancy and frequent ultrasound examinations. A validated questionnaire based on data from an interview-study was distributed to Ro/SSA-positive women supervised with Doppler examinations during their pregnancy (n = 100). The response rate was 79%. The majority of the women (61%) reported that the increased number of ultrasound examinations influenced their pregnancy, but in a positive way, with qualified information and additional support from health care personnel in conjunction with the examinations. Further, the visits to the clinic provided opportunities to see the ultrasound picture of the expected infant. However, one-third of the women also reported stress in relation to the examinations. Fetal echocardiographic surveillance holds many and predominantly positive effects for Ro/SSA-positive women during pregnancy in addition to the medical advantages. © The Author(s) 2015.

  14. Anti-Ro/SSA antibodies are associated with severe mitral valve regurgitation in patients with systemic lupus erythematosus.

    PubMed

    Higuera-Ortiz, Violeta; Mora-Arias, Tania; Castillo-Martinez, Diana; Amezcua-Guerra, Luis M

    2017-05-01

    To assess whether anti-Ro/SSA antibodies are associated with cardiac valve disease in lupus. A single-center, medical chart review was performed. Lupus patients were divided according to its anti-Ro/SSA status and subgroups were compared for valvular abnormalities and other characteristics. Dependence of anti-Ro/SSA reactivity to anti-Ro52/TRIM21 antibodies was also evaluated. Eighty-nine lupus patients were analyzed. The most common valvular abnormalities were tricuspid (60%), mitral (41%) and pulmonary (14%) regurgitation. Thirty-six patients were positive and 53 negative for anti-Ro/SSA antibodies. In patients positive to anti-Ro/SSA, a difference was noted for anti-dsDNA (67 versus 45%; p = 0.04) and anti-La/SSB (19 versus 2%; p = 0.004) antibodies. An association between anti-Ro/SSA antibodies and severe mitral regurgitation was observed; indeed, 4/15 patients with anti-Ro/SSA and mitral regurgitation had severe forms of valvulopathy as compared to only 1/22 patients with mitral regurgitation but negative to such antibody (27 versus 5%; p = 0.02). Anti-Ro/SSA antibodies significantly elevated the risk of severe mitral regurgitation (OR = 5). Anti-Ro52/TRIM21 levels (103 ± 29 versus 42 ± 43 U/mL; p = 0.03) and anti-Ro52/TRIM21: anti-Ro/SSA ratios (0.88 ± 0.02 versus 0.35 ± 0.37; p = 0.03) were higher in patients with mitral valve regurgitation than in those with no valvulopathy. Anti-Ro/SSA antibodies, mainly against Ro52/TRIM21 antigens, may be pathologically involved in lupus-associated mitral valve regurgitation.

  15. Role of salivary anti-SSA/B antibodies for diagnosing primary Sjögren's syndrome.

    PubMed

    Wei, Pan; Li, Chunlei; Qiang, Lu; He, Jing; Li, Zhanguo; Hua, Hong

    2015-03-01

    The diagnosis of primary Sjögren's syndrome (pSS) is complex, and the saliva test is a potential method to improve the existing diagnostic criteria. To estimate the diagnostic accuracy of salivary anti-SSA/B antibodies in primary Sjögren's syndrome (pSS), and to analyze their correlations with clinical and laboratory profiles. This study enrolled 100 pSS patients and 140 non-pSS controls, including 40 rheumatoid arthritis (RA) patients, 40 systemic lupus erythematosus (SLE) patients, and 60 healthy controls. Unstimulated whole saliva and stimulated parotid saliva samples were collected from the subjects. Salivary anti-SSA/B antibodies were measured using an enzyme-linked immunosorbent assay (ELISA). Clinical and laboratory data were retrieved from the medical records. In the pSS group, the sensitivity of anti-SSA and anti-SSB antibodies in whole saliva was 49% and 29%, respectively, and the specificity was 87.5% and 95%. The sensitivity of anti-SSA and anti-SSB antibodies in parotid saliva was 32% and 8%, respectively, and the specificity was 95.52% and 97.86%, respectively. In the pSS group, the diagnostic accuracy of anti-SSA/B antibodies in whole saliva was significantly higher than in parotid saliva (p<0.05), but was significantly lower than in serum (p<0.05). The salivary flow rate in the pSS group positive for whole salivary anti-SSA was significantly lower than in the negative group (p<0.05). The prevalence of rheumatoid factor and antinuclear factor were significantly higher in salivary SSB-positive pSS patients than in SSB-negative patients (p<0.05). Compared to parotid saliva, whole saliva is a more suitable diagnostic fluid. Using salivary anti-SSA/B antibodies as a single test item is insufficient given the relatively low sensitivity. Further studies should investigate the possibility of combining tests for different salivary autoantibodies as a method for diagnosing pSS.

  16. Prolonged corrected QT interval in anti-Ro/SSA-positive adults with systemic lupus erythematosus.

    PubMed

    Bourré-Tessier, Josiane; Clarke, Ann E; Huynh, Thao; Bernatsky, Sasha; Joseph, Lawrence; Belisle, Patrick; Pineau, Christian A

    2011-07-01

    To examine whether anti-Ro/SSA antibodies are associated with an increased risk of corrected QT (QTc) prolongation, and to study the stability of this relationship over time. Patients fulfilling the American College of Rheumatology (ACR) criteria for systemic lupus erythematosus (SLE) were invited to undergo a 12-lead resting electrocardiogram (EKG) in the pilot phase of our project, performed between February 2002 and March 2005. The same study population was used to perform a second similar analysis with a larger sample between April 2005 and May 2007. Multivariate logistic regression models were fit to estimate the cross-sectional association between anti-Ro/SSA and other demographic and clinical variables on QTc prolongation. The other potentially associated factors examined included age, sex, disease duration, lupus activity (Systemic Lupus Erythematosus Disease Activity Index 2000 update), damage (Systemic Lupus International Collaborating Clinics/ACR Damage Index), potassium and magnesium levels, and medications with the potential to prolong the QTc interval. Cross-sectional analysis of the pilot data (n = 150 patients) showed an association of prolonged QTc with the presence of anti-Ro/SSA (adjusted odds ratio [OR] 12.6; 95% confidence interval [95% CI] 2.3, 70.7). In the second larger study (n = 278), the association was replicated, with a narrower 95% CI (adjusted OR 5.1; 95% CI 1.5, 17.4). In the 118 patients with 2 EKG assessments, the results were consistent over time. Anti-Ro/SSA was associated with QTc prolongation in both our pilot data and a larger SLE cohort sample. Patients positive for anti-Ro/SSA may benefit from EKG testing and appropriate counseling should be considered for those identified with QTc prolongation. Copyright © 2011 by the American College of Rheumatology.

  17. Detecting anti-SSA and anti-SSB antibodies in routine analysis: a comparison between double immunodiffusion and immunoblotting.

    PubMed

    Yago, M; Belmonte, M A; Olmos, M J; Beltran, J; Teruel, C; Segarra, M

    1999-05-01

    The aim of this study was to assess the performance of a commercially available procedure for detecting anti-Sjögren's syndrome A (anti-SSA) and anti-Sjögren's syndrome B (anti-SSB) antibodies by immunoblotting (IB) and compare it with double immunodiffusion (DID). We also studied the clinical significance of these profiles in a series of unselected anti-SSA positive patients. Serum samples from 534 patients that were positive on an immunofluorescent screening test using HEp-2 cells were analysed for anti-SSA and anti-SSB antibodies by DID and IB (Biolab Anablot System II), and the results on anti-SSA antibodies were confirmed by an enzyme-linked immunosorbent assay (ELISA). Fifty-five serum samples were found to be positive for anti-SSA antibodies. Among these, 24 were anti-SSA negative by IB but positive by DID and ELISA ('non-blotter sera'), whereas only three serum samples were anti-SSA negative by DID but positive by IB and ELISA. Of the 18 anti-SSB positive serum samples, eight were negative by DID. All the serum samples that were anti-SSB positive by DID were also positive by IB. Anti-SSB antibodies showed a significant association with eye dryness and leucopenia. Anti-52 kDa SSA antibodies were associated with anti-SSB antibodies but showed no significant association with sicca symptoms, while anti-60 kDa SSA antibodies were associated with lower rates of leucopenia. The 'non-blotter' profile showed no significant association with any clinical parameter. IB is less sensitive than DID for detecting anti-SSA antibodies but more sensitive than DID for detecting anti-SSB antibodies. The determination of anti-SSA immunoblotting profiles in patients positive for anti-SSA antibodies by DID does not significantly improve the clinical usefulness of this test. As expected, anti-SSB antibodies were associated with clinical features of Sjögren's disease. Non-blotting (probably conformational) anti-SSA antibodies did not show any further association with clinical

  18. Anti-Ro/SSA-associated corrected QT interval prolongation in adults: the role of antibody level and specificity.

    PubMed

    Lazzerini, Pietro Enea; Capecchi, Pier Leopoldo; Acampa, Maurizio; Morozzi, Gabriella; Bellisai, Francesca; Bacarelli, Maria Romana; Dragoni, Saverio; Fineschi, Irene; Simpatico, Antonella; Galeazzi, Mauro; Laghi-Pasini, Franco

    2011-10-01

    Recent evidence suggests that anti-Ro/SSA antibodies, strongly associated with the development of congenital heart block, may also be arrhythmogenic for the adult heart. In fact, anti-Ro/SSA-positive patients with connective tissue disease (CTD) frequently display corrected QT (QTc) prolongation associated with an increase in ventricular arrhythmias. However, QTc prolongation prevalence markedly differs throughout the studies (10-60%), but the reason why is not yet clear. The aim of this study was to evaluate whether anti-Ro/SSA-associated QTc prolongation in adult patients with CTD is related to antibody level and specificity. Forty-nine adult patients with CTD underwent a resting 12-lead electrocardiogram recording to measure QTc interval, and a venous withdrawal to determine anti-Ro/SSA antibody level and specificity (anti-Ro/SSA 52 kd and anti-Ro/SSA 60 kd) by immunoenzymatic methods and Western blotting. In our population, a direct correlation was demonstrated between anti-Ro/SSA 52-kd level and QTc duration (r = 0.38, P = 0.007), patients with a prolonged QTc had higher levels of anti-Ro/SSA 52 kd with respect to those with a normal QTc (P = 0.003), and patients with a moderate to high level (≥50 units/ml) of anti-Ro/SSA 52 kd showed a longer QTc interval (P = 0.008) and a higher QTc prolongation prevalence (P = 0.008) than those with a low positive/negative level (<50 units/ml). On the contrary, no association was found between QTc and anti-Ro/SSA 60-kd level. In anti-Ro/SSA-positive adult patients with CTD, the occurrence of QTc prolongation seems strictly dependent on the anti-Ro/SSA 52-kd level. This finding, possibly explaining the different QTc prolongation prevalence reported, strengthens the hypothesis that an extremely specific autoimmune cross-reaction is responsible for the anti-Ro/SSA-dependent interference on ventricular repolarization. Copyright © 2011 by the American College of Rheumatology.

  19. Atomes du big bang : premiere detection

    NASA Astrophysics Data System (ADS)

    Bonnet-Bidaud, J. M.

    1994-09-01

    Ce fut au Keck d'ouvrir le bal, en debusquant du deuterium a plus de 10 milliards d'annees-lumiere. Puis, en juillet, vint l'annonce qu'Hubble avait apercu de l'helium flottant dans le milieu intergalactque lontain. Que ces deux prouesses realisees a la lumiere de quasars se confirment et elles ouvriraient enfin la chasse aux atomes primordiaux nes dans les trois premieres minutes de l'Univers. Avec toutefois un probleme : l'une apporterait de l'eau au moulin du Big Bang, mais l'autre ferait plutot figure de pave dans la mare ...

  20. SSA-MOA: a novel CTC isolation platform using selective size amplification (SSA) and a multi-obstacle architecture (MOA) filter.

    PubMed

    Kim, Minseok S; Sim, Tae Seok; Kim, Yeon Jeong; Kim, Sun Soo; Jeong, Hyoyoung; Park, Jong-Myeon; Moon, Hui-Sung; Kim, Seung Il; Gurel, Ogan; Lee, Soo Suk; Lee, Jeong-Gun; Park, Jae Chan

    2012-08-21

    Circulating tumor cells (CTCs) have gained increasing attention as physicians and scientists learn more about the role these extraordinarily rare cells play in metastatic cancer. In developing CTC technology, the critical criteria are high recovery rates and high purity. Current isolation methods suffer from an inherent trade-off between these two goals. Moreover, ensuring minimal cell stress and robust reproducibility is also important for the clinical application of CTCs. In this paper, we introduce a novel CTC isolation technology using selective size amplification (SSA) for target cells and a multi-obstacle architecture (MOA) filter to overcome this trade-off, improving both recovery rate and purity. We also demonstrate SSA-MOA's advantages in minimizing cell deformation during filter transit, resulting in more stable and robust CTC isolation. In this technique, polymer microbeads conjugated with anti-epithelial cell adhesion molecules (anti-EpCAM) were used to selectively size-amplify MCF-7 breast cancer cells, definitively differentiating from the white blood cells (WBCs) by avoiding the size overlap that compromises other size selection methods. 3 μm was determined to be the optimal microbead diameter, not only for size discrimination but also in maximizing CTC surface coverage. A multi-obstacle architecture filter was fabricated using silicon-on-glass (SOG) technology-a first such application of this fabrication technique-to create a precise microfilter structure with a high aspect ratio. The filter was designed to minimize cell deformation as simulation results predicted that cells captured via this MOA filter would experience 22% less moving force than with a single-obstacle architecture. This was verified by experiments, as we observed reliable cell capture and reduced cell deformation, with a 92% average recovery rate and 351 peripheral blood leukocytes (PBL) per millilitre (average). We expect the SSA-MOA platform to optimize CTC recovery rates

  1. Pregnancy outcome in 100 women with autoimmune diseases and anti-Ro/SSA antibodies: a prospective controlled study.

    PubMed

    Brucato, A; Doria, A; Frassi, M; Castellino, G; Franceschini, F; Faden, D; Pisoni, M Pia; Solerte, L; Muscarà, M; Lojacono, A; Motta, M; Cavazzana, I; Ghirardello, A; Vescovi, F; Tombini, V; Cimaz, R; Gambari, P F; Meroni, P L; Canesi, B; Tincani, A

    2002-01-01

    Anti-Ro/SSA antibodies are associated with neonatal lupus but are also considered a possible cause for unexplained pregnancy loss and adverse pregnancy outcome. In a large multicentres cohort study we have prospectively followed 100 anti-Ro/SSA positive women (53 systemic lupus erythematosus (SLE)) during their 122 pregnancies and 107 anti-Ro/SSA negative women (58 SLE) (140 pregnancies). Anti-Ro/SSA antibodies were tested by immunoblot and counterimunoelectrophoresis. Mean gestational age at delivery (38 vs 37.9 weeks), prevalence of pregnancy loss (9.9 vs 18.6%), preterm birth (21.3 vs 13.9%), cesarean sections (49.2 vs 53.4%), premature rupture of membranes (4.9 vs 8.1%), preeclampsia (6.6 vs 8%), intrauterine growth retardation (0 vs 2.3%)and newborns small for gestational age (11.5 vs 5.8%) were similar in anti-Ro/SSA positive and negative SLE mothers; findings were similar in non-SLE women. Two cases of congenital heart block were observed out of 100 anti-Ro/SSA positive women. In conclusion, anti-Ro/SSA antibodies are responsible for congenital heart block but do not affect other pregnancy outcomes, both in SLE and in non-SLE women. The general outcome of these pregnancies is now very good, ifprospectively followed by multidisciplinary teams with ample experience in this field.

  2. Outcomes of fetal echocardiographic surveillance in anti-SSA exposed fetuses at a large fetal cardiology center.

    PubMed

    Krishnan, Anita; Arya, Bhawna; Moak, Jeffrey P; Donofrio, Mary T

    2014-12-01

    Echocardiography screening in anti-SSA antibody exposed fetuses is controversial. The aim of this study is to evaluate utility of fetal echocardiography in anti-SSA exposure. Echocardiograms performed over 9 years for maternal anti-SSA exposure were reviewed for atrioventricular (AV) block, cardiomyopathy, arrhythmias, effusion, valve abnormalities, or other abnormalities identified by the echocardiographer. Fetuses with AV block referred to our institution and subsequently found to be anti-SSA exposed were also identified. Six hundred thirty six echocardiograms were performed on 140 fetuses (Cohort 1) of 134 women screened for maternal anti-SSA +/- anti-SSB antibodies. No fetuses developed second or third-degree AV block or cardiomyopathy (odds ratio 0.1, CI 0.0051 to 1.9410, p = 0.13). Dexamethasone was administered to three fetuses for sinus bradycardia, echogenicity near AV node, and ventricular systolic dysfunction with valve regurgitation; all normalized. Screening echocardiograms identified: sinus bradycardia (n = 1), PR prolongation (n = 5), premature atrial contractions (n = 3), valve regurgitation (n = 24), echogenic myocardium (n = 4), and pericardial effusion (n = 1). Isolated tricuspid regurgitation and first-degree AV block did not progress. Nine cases of SSA-mediated AV block (Cohort 2) were referred after heart block developed. Serial fetal echocardiography in anti-SSA exposed fetuses did not detect AV block. In rare cases, dexamethasone treatment may have affected disease course. © 2014 John Wiley & Sons, Ltd.

  3. Ro52/SSA sensitizes cells to death receptor-induced apoptosis by down-regulating c-FLIP(L).

    PubMed

    Zhang, Jing; Fang, Lei; Zhu, Xuguo; Qiao, Yiting; Yu, Mei; Wang, Lu; Chen, Yuan; Yin, Wu; Hua, Zi-Chun

    2012-05-01

    Ro52/SSA is an autoantigen that presents in patients with SS (Sjögren's syndrome) and SLE (systemic lupus erythematosus). It increases cell death and redistributes itself to apoptotic blebs, but its pro-apoptotic function has not been completely identified. Overexpression of Ro52/SSA promoted cell apoptosis induced by DR (death receptor) in caspase-8-dependent manner. Ro52/SSA expression down-regulated c-FLIP(L) [cellular (Fas-associated death domain)-like interleukin 1β-converting enzyme-inhibitory protein long form] expression, and Ro52/SSA siRNAs (small interfering RNAs) increased c-FLIP(L) production, indicating that Ro52/SSA plays a role in c-FLIP(L) regulation. Ro52/SSA negatively regulated c-FLIP(L) transcriptional level probably by suppressing NF-κB (nuclear factor κB) signalling. The data suggest that Ro52/SSA is involved in DR-mediated apoptosis by regulating c-FLIP(L).

  4. Effects of aspect ratio (AR) and specific surface area (SSA) on cytotoxicity and phototoxicity of ZnO nanomaterials.

    PubMed

    Yin, Hong; Casey, Philip S

    2015-04-01

    With growing interests in the applications of high aspect ratio (AR) ZnO nanomaterials (NMs), their potential toxicity to human health and nature environment remains a critical concern because these NMs have extremely large specific surface area (SSA) that could dramatically enhance interactions between NMs and surrounding molecules. In addition, originated to their intrinsic photocatalytical activity, ZnO NMs may induce phototoxicity under environmentally UV exposure. In this paper, ZnO spheres, grains, rods and needles with increasing AR (from 1.1 to 17.8) and various SSA (from 2.0 m(2) g(-1) to 27.4 m(2) g(-1)) were used to study the influence of AR and SSA on viabilities of WIL2-NS human lymphoblastoid cells in both dark and UV conditions. In dark, SSA was the main influencing factor for toxicity of NMs with low AR (spheres, grains and rods) and smaller SSA leads to higher cell viability. However, ZnO needles with the smallest SSA did not further enhance cell viability which may be possibly attributed to its high AR. Cell viability measured under UV irradiation did not show evident relationship with SSA or AR, but indicated that lower photocatalytic activity could mitigate phototoxicity. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Phenotypic and chemotypic studies using Arabidopsis and yeast reveal that GHB converts to SSA and induce toxicity.

    PubMed

    Mekonnen, Dereje Worku; Ludewig, Frank

    2016-07-01

    γ-Hydroxybutyric acid (GHB) is a naturally occurring compound. It is detected in organisms such as yeasts, plants and mammals. GHB is produced from the reduction of succinic semialdehyde (SSA) by the activity of GHB dehydrogenase. Arabidopsis genome contains two GHB dehydrogenase encoding genes. The accumulation of GHB in ssadh mutants led to the speculation that GHB is the cause of aberrant phenotypes. Conversely, the accumulation of GHB in Arabidopsis plants subjected to abiotic stresses was described as a way of avoiding SSA induced damage. To resolve these contrasting views on GHB, we examined the effect of exogenous GHB and SSA on the growth of yeast and Arabidopsis plants. GHB concentrations up to 1.5 mM didn't affect shoots of Arabidopsis plants; however, root growth was inhibited. In contrast, 0.3 mM SSA has severely affected the growth of plants. Treatment of yeast wild-type strain with 10 mM SSA and 10 mM GHB didn't affect the growth. However, the growth of yeast uga2 mutant was greatly inhibited by the same concentration of SSA, but not GHB. Metabolic analysis and enzyme activity assay on native gel showed that Arabidopsis, but not yeast, possesses a GHB dehydrogenase activity that converts GHB back to SSA. The enzymatic assay has also indicated the existence of an additional GHB dehydrogenase encoding gene(s) in Arabidopsis genome. Taken together, we conclude that GHB is less toxic than SSA. Its accumulation in ssadh mutants and during abiotic stresses is a response to avoid the SSA induced damage.

  6. MELiSSA Pilot Plant: A facility for ground demonstration of a closed life support system

    NASA Astrophysics Data System (ADS)

    Godia, Francesc; Fossen, Arnaud; Peiro, Enrique; Gerbi, Olivier; Dussap, Gilles; Leys, Natalie; Arnau, Carolina; Milian, Ernest

    MELiSSA (Micro Ecological Life Support System Alternative) is an international collaborative effort focused on the development of a Life Support System for long-term Space missions. The goals of the MELiSSA loop are the recovery of food, water and oxygen from wastes, i.e. CO2 and organic wastes, using light as a source of energy. It is conceived as a series of compartments, each one performing a specific function within this cycle, inspired in the terrestrial ecological systems. Each one of the compartments is colonized with specific bacteria or higher plants depending on its dedicated function. Therefore, its design and operational conditions should guarantee that only a given specific biological activity takes place in each compartment. Moreover, this has to be done in a controlled manner, both at the subsystems level (i.e., compartments) and at the overall system level (i.e., complete loop). In order to achieve the complete operation of such a Closed Ecological System, in a first step each compartment has to be developed at individual level, and its operation demonstrated under its associated control law. In a second step, the complete loop needs to be integrated by the connection of the different compartments in the gas, loop and solid phases. An extensive demonstration of MELiSSA loop under terrestrial conditions is a mandatory step in the process of its adaptation to space. This is the main goal of the MPP. The demonstration scenario for the MPP is the respiration equivalent of a human being, and production of 20 percent of the diet of one person. To serve this goal, the different compartments of the MELiSSA loop have been designed and sized at the pilot scale level, and further characterized. Nowadays, the focus of the MELiSSA Pilot Plant is on the integration of its compartments. To this end, the integration challenge is concentrated in three compartments devoted to the following functions: nitrification (Compartment 3, an axenic co-culture of Nitrosomonas

  7. Remote Ultra-low Light Imaging (RULLI) For Space Situational Awareness (SSA): Modeling And Simulation Results For Passive And Active SSA

    SciTech Connect

    Thompson, David C; Shirey, Robert L; Roggemann, Michael C; Gudimetla, Rao

    2008-01-01

    Remote Ultra-Low Light Imaging detectors are photon limited detectors developed at Los Alamos National Laboratories. RULLI detectors provide a very high degree of temporal resolution for the arrival times of detected photoevents, but saturate at a photo-detection rate of about 10{sup 6} photo-events per second. Rather than recording a conventional image, such as output by a charged coupled device (CCD) camera, the RULLI detector outputs a data stream consisting of the two-dimensional location, and time of arrival of each detected photo-electron. Hence, there is no need to select a specific exposure time to accumulate photo-events prior to the data collection with a RULLI detector this quantity can be optimized in post processing. RULLI detectors have lower peak quantum efficiency (from as low as 5% to perhaps as much as 40% with modern photocathode technology) than back-illuminated CCD's (80% or higher). As a result of these factors, and the associated analyses of signal and noise, we have found that RULLI detectors can play two key new roles in SSA: passive imaging of exceedingly dim objects, and three-dimensional imaging of objects illuminated with an appropriate pulsed laser. In this paper we describe the RULLI detection model, compare it to a conventional CCD detection model, and present analytic and simulation results to show the limits of performance of RULLI detectors used for SSA applications at AMOS field site.

  8. BOREAS TF-11 SSA-Fen 1996 Water Surface Film Capping Data

    NASA Technical Reports Server (NTRS)

    Billesbach, David P.; Hall, Forrest G. (Editor); Knapp, David E. (Editor)

    2000-01-01

    The BOREAS TF-11 team gathered a variety of data to complement its tower flux measurements collected at the SSA-Fen site. The data described in this document were made by the TF-11 team at the SSA-Fen site to quantify the effect that the films observed to form on open water surfaces had on the transfer of carbon dioxide and methane from the water to the air. Measurements of fluxes of carbon dioxide and methane were made in 1994 and in 1996 using the chamber flux method. A gas chromatograph and a LI-COR LI-6200 were used to measure concentrations and to calculate the fluxes. The data are stored in tabular ASCII files.

  9. BOREAS RSS-17 Xylem Flux Density Measurements at the SSA-OBS Site

    NASA Technical Reports Server (NTRS)

    Zimmerman, Reiner; Way, JoBea; McDonald, Kyle; Nickeson, Jaime (Editor); Hall, Forrest G. (Editor); Smith, David E. (Technical Monitor)

    2000-01-01

    As part of its efforts to determine environmental and phenological states from radar imagery, the Boreal Ecosystem-Atmosphere Study (BOREAS) Remote Sensing Science (RSS)-17 team collected in situ tree xylem flow measurements for one growing season on five Picea mariana (black spruce) trees. The data were collected to obtain information on the temporal and spatial variability in water uptake by trees in the Southern Study Area-Old Black Spruce (SSA-OBS) stand in the BOREAS SSA. Temporally, the data were collected in 30-minute intervals for 120 days from 31 May 1994 until 27 September 1994. The data are stored in tabular ASCII files. The xylem flux data are available from the Earth Observing System Data and Information System (EOSDIS) Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC). The data files are available on a CD-ROM (see document number 20010000884).

  10. Medicare premium buy-in programs: results of SSA demonstration projects.

    PubMed

    Nadel, M; Alecxih, L; Parent, R; Sears, J

    2000-01-01

    Three programs known collectively as the Medicare buy-in programs are available to pay Medicare Part B premiums and, in some cases, other medical expenses for certain low-income individuals. The Health Care Financing Administration administers those programs, with most functions performed by the states. The Social Security Administration (SSA) plays an indirect role in the buy-in programs: with certain exceptions, people who qualify for Medicare and hence for buy-in are beneficiaries of Social Security retirement or disability programs. SSA is often cited as an agency that might be able to increase enrollment in the buy-in programs through outreach to its beneficiaries and by acting as an intermediary in the enrollment process. The three buy-in programs have different requirements for eligibility. The Qualified Medicare Beneficiary (QMB) program includes individuals who have Part A Medicare benefits and whose income does not exceed 100 percent of federal poverty guidelines. People in the Specified Low-Income Medicare Beneficiary (SLMB) program are individuals who would otherwise be QMBs but whose income is more than 100 percent but less than 120 percent of poverty guidelines. People in the Qualified Individual (QI) program are those who meet the other criteria but whose income is less than 175 percent of poverty guidelines. Various reports and studies by government agencies and advocacy organizations conclude that the buy-in programs are not reaching many of the people who are eligible. Low enrollment appears to be a particular issue for the SLMB and QI programs. States have tried various outreach efforts, but the effectiveness of those efforts has not been adequately assessed. In 1998, Congress mandated that SSA conduct a demonstration project to determine how to increase participation in the buy-in programs. The project tested six different administrative models in which outreach letters were sent to potential beneficiaries asking them to contact SSA and then be

  11. BOREAS TF-11 CO2 and CH4 Flux Data from the SSA-Fen

    NASA Technical Reports Server (NTRS)

    Valentine, David W.; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOREAS TF-11 team collected several data sets in its efforts to fully describe the flux and site characteristics at the SSA-Fen site. This data set contains fluxes of methane and carbon dioxide at the SSA-Fen site measured using static chambers. The measurements were conducted as part of a 2 x 2 factorial experiment in which we added carbon (300 g/sq m as wheat straw) and nitrogen (6 g/sq m as urea) to four replicate locations in the vicinity of the TF-11 tower. In addition to siting and treatment variables, it reports air temperature and water table height relative to the average peat surface during each measurement. The data set covers the period from the first week of June 1994 through the second week of September 1994. The data are stored in tabular ASCII files.

  12. Higher Plants in Space for MELiSSA -Literature Review and Future Directions

    NASA Astrophysics Data System (ADS)

    Zabrodina, Marina; Kittang, Ann-Iren; Coelho, Liz Helena; Karoliussen, Irene; Aase Wolff, Silje; Iversen, Tor-Henning

    The human exploration of space requires the development of closed life support systems to regenerate oxygen, purify water, and produce food. MELiSSA (Micro-Ecological Life Support System Alternative) is a model system for advanced life support based on different microbial species and higher plants. The main objective of the LiRHiPliSMe (Literature Review of Higher Plants in Space for MELiSSA) project was to elaborate the preliminary roadmap for higher plant research activities for the MELiSSA project Phase 2 (Preliminary Space Experiments). The first task was to establish an understanding of the current knowledge concerning how higher plant will adapt to Moon/Mars physical factors different from Earth with focus on reduced gravity, space radiation, variations in magnetic field and combined effects of these factors. The literature related to how Moon/Mars physical factors can affect genetic processes, growth regulators, development, morphology, water and nutrients transport, gas exchange and metabolism of higher plants during one life cycle were collected. The possible effects of the space environment on the plant role as a food and on the mass balance in a Life Support System that includes a Higher Plant Compartment are reviewed. Based on this literature review there was made an assessment of where new or extended scientific knowledge about space factors effects on higher plant growth and development is needed. The requirements for research activities on higher plants in enclosed life support systems were identified. The required higher plant research activities for MELiSSA phase 2 both on ground and in space were placed in a timescale from the present until higher plants can be grown in closed life support systems on Moon and Mars.

  13. Vector Topographic Map Data over the BOREAS NSA and SSA in SIF Format

    NASA Technical Reports Server (NTRS)

    Knapp, David; Nickeson, Jaime; Hall, Forrest G. (Editor)

    2000-01-01

    This data set contains vector contours and other features of individual topographic map sheets from the National Topographic Series (NTS). The map sheet files were received in Standard Interchange Format (SIF) and cover the BOReal Ecosystem-Atmosphere Study (BOREAS) Northern Study Area (NSA) and Southern Study Area (SSA) at scales of 1:50,000 and 1:250,000. The individual files are stored in compressed Unix tar archives.

  14. BOREAS TF-2 SSA-OA Tethersonde Meteorological and Ozone Data

    NASA Technical Reports Server (NTRS)

    Arnold, A. James; Mickle, Robert E.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux-2 (BOREAS TF-2) team collected meteorological and ozone measurements from instruments mounted below a tethered balloon. These data were collected at the Southern Study Area Old Aspen (SSA-OA) site to extend meteorological and ozone measurements made from the flux tower to heights of 300 m. The tethersonde operated during the fall of 1993 and the spring, summer, and fall of 1994. The data are available in tabular ASCII files.

  15. A Comparison of JPDA and Belief Propagation for Data Association in SSA

    DTIC Science & Technology

    2014-09-01

    A COMPARISON OF JPDA AND BELIEF PROPAGATION FOR DATA ASSOCIATION IN SSA Mark Rutten,∗ Jason Willams∗,† and Neil Gordon∗,‡ ∗NSID, Defence Science and...to which object. Realities of imperfect sensors mean that the association must be made in the presence of missed detections, false alarms and...Using an approximate inference algorithm, belief propagation (BP), on the graphical model results in an algorithm that is both computationally efficient

  16. Building a Local Space Situational Awareness (SSA) Architecture Using Hosted Payloads

    DTIC Science & Technology

    2013-09-01

    applications such as remote sensing , navigation and scientific applications. However, the use of hosted payloads with respect to SSA was limited...operate unattended. For that reason, if a component fails, only remote maintenance actions can be carried out. Such actions must usually be preplanned...against each other with respect to effectiveness, affordability, and risk (Space and Missile Systems Center 2005, 3). There is the remote possibility

  17. BOREAS TF-11 SSA-Fen 1995 Leaf Area Index Data

    NASA Technical Reports Server (NTRS)

    Arkebauer, Timothy J.; Hall, Forrest G. (Editor); Knapp, David E. (Editor)

    2000-01-01

    The BOREAS TF-11 team gathered a variety of data to complement its tower flux measurements collected at the SSA-Fen site. These data are LAI measurements made by the TF-11 team throughout the 1995 growing season. The data include the LAI of plants that fall into six categories: total, Carex spp., Betula pumila, Menyanthes trifoliata, Salix spp., and other vascular plants. The data are stored in tabular ASCII files.

  18. Next generation of space based sensor for application in the SSA space weather domain.

    NASA Astrophysics Data System (ADS)

    Jansen, Frank; Kudela, Karel; Behrens, Joerg

    Next generation of space based sensor for application in the SSA space weather domain. F. Jansen1, K. Kudela2, J. Behrens1 and NESTEC consortium3 1DLR, Bremen, Germany 2IEP SAS Kosice, Slovakia 3NESTEC consortium members (DLR Bremen, DESY Hamburg, MPS Katlenburg-Lindau, CTU Prague, University of Twente, IEP-SAS Kosice, UCL/MSSL, University of Manchester, University of Surrey, Hermanus Magnetic Observatory, North-West University Potchefsroom, University of Montreal) High energy solar and galactic cosmic rays have twofold importance for the SSA space weather domain. Cosmic rays have dangerous effects for space, air and ground based assets, but on the other side cosmic rays are direct measure tools for real time space weather warning. A review of space weather related SSA results from operating global cosmic ray networks (especially those by neutron monitors and by muon directional telescopes), its limitations and main questions to be solved, is presented. Especially those recent results, received in real time and with high temporal resolution, are reviewed and discussed. In addition the relevance of these monitors and telescopes in forecasting geomagnetic disturbances are checked. Based on this study result, a next generation of highly miniaturized hybrid silicon pixel device (Medipix sensor) will be described for the following, beyond state-of-the-art application: a SSA satellite for high energy solar and galactic cosmic ray spectrum measurement, with a space plasma environment data package and CME real time imaging by means of cosmic rays. All data management and processing will be carried out on the satellite in real time. Insofar a high reduction of data and transmission to ground station of finalized space weather relevant data and images are foreseen.

  19. The experiences of pregnancy in women with SSA/Ro52 autoantibodies.

    PubMed

    Tingström, Joanna; Barimani, Mia; Sonesson, Sven-Erik; Wahren-Herlenius, Marie; Henriksson, Elisabet Welin

    2010-12-01

     Congenital heart block may develop in the foetus during pregnancy in SSA/Ro52 autoantibody-positive women. The aim of this study was to investigate how women with SSA/Ro52 autoantibodies experience their pregnancy in terms of the risk of developing foetal heart block, and in undergoing serial ultrasound Doppler echocardiography to detect early signs of congenital heart block.  Data were collected through individual semi-structured interviews with SSA/Ro52-positive women post-pregnancy (n = 14). The interviews were audio-taped, transcribed verbatim and analysed according to qualitative content analysis.  Three categories emerged from the responses: information, emotional response and support. The information received prior to and during early pregnancy was focused on the need for attending a specialized antenatal clinic, and information on the risk for congenital heart block was scarce or missing. During gestational weeks 18-24, when the ultrasound/Doppler examinations were performed, all women described increased stress. However, the interaction with the caregivers made the women feel more safe and secure. Several women also said that they did not emotionally acknowledge the pregnancy until after gestational week 24. None had been offered psychological support.  There is a need for structured information and organized programmes for the surveillance of women who are SSA/Ro52 positive during their pregnancy. Further, offering psychological support to the women and their families to manage the stress and to facilitate the early attachment to the child should be considered. Copyright © 2010 John Wiley & Sons, Ltd.

  20. BOREAS TF-4 CO2 and CH4 Chamber Flux Data from the SSA

    NASA Technical Reports Server (NTRS)

    Anderson, Dean; Striegl, Robert; Wickland, Kimberly; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOREAS TF-4 team measured fluxes of CO2 and CH4 across the soil-air interface in four ages of jack pine forest at the BOREAS SSA during August 1993 to March 1995. Gross and net flux of CO2 and flux of CH4 between soil and air are presented for 24 chamber sites in mature jack pine forest, 20-year-old, 4-year-old, and clear cut areas. The data are stored in tabular ASCII files.

  1. Surviving space flight: case study on MELiSSA's CIII nitrifying compartment

    NASA Astrophysics Data System (ADS)

    Ilgrande, Chiara; Lasseur, Christophe; Mastroleo, Felice; Paille, Christel; Leys, Natalie; Morozova, Julia; Ilyin, Vyacheslav; Clauwaert, Peter; Christiaens, Marlies E. R.; Lindeboom, Ralph E. F.; Vlaeminck, Siegfried; Prat, Delphine; Arroyo, Jose M. C.; Conincx, Ilse; Van Hoey, Olivier; Roume, Hugo; Udert, Kai; Sas, Benedikt

    2016-07-01

    Space synthetic biology offers key opportunities for long-term space missions. Planets mining, terraformation, space medicine and Life Support technologies would all benefit from an integrative biological approach. However, space is a harsh environment for life: microgravity, temperature, UV and cosmic radiation can affect the health and functionality of microorganisms and plants, possibly preventing the optimal performance of the systems. The European Space Agency's Life Support System (MELiSSA) has been developed as a model for future long term Space missions and Space habitation. MELiSSA is a 5 compartment artificial ecosystem with microorganisms and higher, that aims at completely recycling gas, liquid and solid waste. In this study, the survival and functional activity after Lower Earth Orbit conditions of microbial nitrogen conversions, relevant for MELiSSA's CIII compartment, was tested. Synthetic communities containing Nitrosomonas europeae, Nitrosomonas ureae, Nitrobacter winogradskyi, Nitrospira moscoviensis and Cupriavidus pinatubonensis were exposed to the Lower Earth Orbit conditions of the International Space Station (ISS) for 7 days. Nitrosomonas europeae, Nitrobacter winogradskyi, Cupriavidus pinatubonensis, and three mixed communities (a urine nitrification sludge, a sludge containing aerobic ammonia oxidizing bacteria and anammox bacteria (OLAND), and an aquaculture sludge containing ammonia oxidizing archaea) were exposed to Lower Earth Orbit conditions for 44 days. Survival after both space flights was demonstrated because nitritation, nitratation, denitrification and anammox activity could be restored at a rate comparable to ground storage conditions. Our results validate the potential survival feasibility and suggest future space applications for N-related microorganisms.

  2. Pregnancy Outcomes in Patients with Autoimmune Diseases and Anti-Ro/SSA Antibodies

    PubMed Central

    Cimaz, Rolando; Caporali, Roberto; Ramoni, Véronique; Buyon, Jill

    2013-01-01

    Anti-Ro/SSA antibodies are associated with neonatal lupus (congenital heart block (CHB), neonatal transient skin rash, hematological and hepatic abnormalities), but do not negatively affects other gestational outcomes, and the general outcome of these pregnancies is now good, when followed by experienced multidisciplinary teams. The prevalence of CHB, defined as an atrioventricular block diagnosed in utero, at birth, or within the neonatal period (0–27 days after birth), in the offspring of an anti-Ro/SSA-positive women is 1–2%, of neonatal lupus rash around 10–20%, while laboratory abnormalities in asymptomatic babies can be detected in up to 27% of cases. The risk of recurrence of CHB is ten times higher. Most of the mothers are asymptomatic at delivery and are identified only by the birth of an affected child. Half of these asymptomatic women develop symptoms of a rheumatic disease, most commonly arthralgias and xerophtalmia, but few develop lupus nephritis. A standard therapy for CHB is still matter of investigation, although fluorinated corticosteroids have been reported to be effective for associated cardiomyopathy. Serial echocardiograms and obstetric sonograms, performed at least every 1–2 weeks starting from the 16th week of gestational age, are recommended in anti-Ro/SSA-positive pregnant women to detect early fetal abnormalities that might be a target of preventive therapy. PMID:20012231

  3. SSA-ME Detection of cancer driver genes using mutual exclusivity by small subnetwork analysis

    PubMed Central

    Pulido-Tamayo, Sergio; Weytjens, Bram; De Maeyer, Dries; Marchal, Kathleen

    2016-01-01

    Because of its clonal evolution a tumor rarely contains multiple genomic alterations in the same pathway as disrupting the pathway by one gene often is sufficient to confer the complete fitness advantage. As a result, many cancer driver genes display mutual exclusivity across tumors. However, searching for mutually exclusive gene sets requires analyzing all possible combinations of genes, leading to a problem which is typically too computationally complex to be solved without a stringent a priori filtering, restricting the mutations included in the analysis. To overcome this problem, we present SSA-ME, a network-based method to detect cancer driver genes based on independently scoring small subnetworks for mutual exclusivity using a reinforced learning approach. Because of the algorithmic efficiency, no stringent upfront filtering is required. Analysis of TCGA cancer datasets illustrates the added value of SSA-ME: well-known recurrently mutated but also rarely mutated drivers are prioritized. We show that using mutual exclusivity to detect cancer driver genes is complementary to state-of-the-art approaches. This framework, in which a large number of small subnetworks are being analyzed in order to solve a computationally complex problem (SSA), can be generically applied to any problem in which local neighborhoods in a network hold useful information. PMID:27808240

  4. SSA-ME Detection of cancer driver genes using mutual exclusivity by small subnetwork analysis.

    PubMed

    Pulido-Tamayo, Sergio; Weytjens, Bram; De Maeyer, Dries; Marchal, Kathleen

    2016-11-03

    Because of its clonal evolution a tumor rarely contains multiple genomic alterations in the same pathway as disrupting the pathway by one gene often is sufficient to confer the complete fitness advantage. As a result, many cancer driver genes display mutual exclusivity across tumors. However, searching for mutually exclusive gene sets requires analyzing all possible combinations of genes, leading to a problem which is typically too computationally complex to be solved without a stringent a priori filtering, restricting the mutations included in the analysis. To overcome this problem, we present SSA-ME, a network-based method to detect cancer driver genes based on independently scoring small subnetworks for mutual exclusivity using a reinforced learning approach. Because of the algorithmic efficiency, no stringent upfront filtering is required. Analysis of TCGA cancer datasets illustrates the added value of SSA-ME: well-known recurrently mutated but also rarely mutated drivers are prioritized. We show that using mutual exclusivity to detect cancer driver genes is complementary to state-of-the-art approaches. This framework, in which a large number of small subnetworks are being analyzed in order to solve a computationally complex problem (SSA), can be generically applied to any problem in which local neighborhoods in a network hold useful information.

  5. Clinical characteristics of children with positive anti-SSA/SSB antibodies.

    PubMed

    Chen, Pei-Hsuan; Yang, Yao-Hsu; Lin, Yu-Tsan; Lee, Jyh-Hong; Wang, Li-Chieh; Yu, Hsin-Hui; Chiang, Bor-Luen

    2014-08-01

    This study aimed to characterize the manifestations of clinical symptoms and signs, primary rheumatic diseases, and other autoantibodies in pediatric patients with positive anti-SSA and/or anti-SSB antibodies. Subjects under age 18 with positive anti-SSA and/or anti-SSB antibodies were screened and enrolled in a tertiary hospital in Taiwan. Data were collected via medical records,including age, gender, onset of the primary rheumatic disease, clinical symptoms and signs, and the medication used. Schirmer test for Sjögren's syndrome (SS) screening was performed in all enrolled patients. Among twenty enrolled subjects, seventeen of them had systemic lupus erythematosus; four of them were diagnosed as SS with positive Schirmer test. In addition to antinuclear antibodies and anti-DNA antibodies, other common autoantibodies were anti-RNP antibodies (50 %) and anti-Sm antibodies(30 %). The most common symptoms were arthritis (60 %)followed by malar rash (40 %). In conclusion, we observed that a low proportion of childhood SS (4/20) exists in our patients with positive SSA and/or anti-SSB antibodies. It is suggested that clinicians should focus more on the clinical symptoms in these patients, rather than undertaking invasive diagnostic interventions to rule out Sjögren's syndrome.

  6. [Anti- SSA/Ro and Anti-SSB/ La Antibodies in Patients with Yusho].

    PubMed

    Tsuji, Hiroshi

    2015-05-01

    To investigate chronic immune effects of polychlorinated biphenyl (PCB) and polychlorinated dibenzofuran (PCDF), anti-SSA/Ro and anti-SSB/La antibodies were studied in serum of 213 patients with Yusho and 63 control subjects in 2013. Anti-SSA/Ro antibodies were found in 4.2% (9/213) of patients with Yusho and 1.6% (1/63) of control subjects. The prevalence rates of anti-SSA/Ro antibodies in Yusho patients were not associated with blood PCB concentration or blood 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) concentration. Anti-SSB/La antibodies were found in 1.4% (3/213) of patients of Yusho, but none of controls. Furthermore, high concentrations of PCB and 2,3,4,7,8-PeCDF were present in Yusho patients with anti-SSB/La antibodies. We conclude that anti-SSB/La antibody is present in patients with Yusho, and it may be associated with PCB and 2,3,4,7,8-PeCDF in the blood.

  7. 78 FR 12128 - Privacy Act of 1974; Computer Matching Program (SSA/Department of the Treasury, Internal Revenue...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY... Service (IRS))--Match Number 1305 AGENCY: Social Security Administration (SSA). ACTION: Notice of a... Counsel, Social Security Administration, 617 Altmeyer Building, 6401 Security Boulevard, Baltimore, MD...

  8. 78 FR 37875 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Bureau of the Fiscal Service...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-24

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY... (Fiscal Service))--Match Number 1304 AGENCY: Social Security Administration (SSA). ACTION: Notice of a... Disclosure, Office of the General Counsel, Social Security Administration, 617 Altmeyer Building, 6401...

  9. 20 CFR 408.1235 - How does the State transfer funds to SSA to administer its recognition payment program?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Federal Administration of State Recognition... total amounts paid by SSA on behalf of the State during the current Federal fiscal year; the...

  10. 20 CFR 408.1235 - How does the State transfer funds to SSA to administer its recognition payment program?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Federal Administration of State Recognition... total amounts paid by SSA on behalf of the State during the current Federal fiscal year; the...

  11. 20 CFR 408.1235 - How does the State transfer funds to SSA to administer its recognition payment program?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Federal Administration of State Recognition... total amounts paid by SSA on behalf of the State during the current Federal fiscal year; the...

  12. 20 CFR 408.1235 - How does the State transfer funds to SSA to administer its recognition payment program?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Federal Administration of State Recognition... total amounts paid by SSA on behalf of the State during the current Federal fiscal year; the...

  13. 20 CFR 411.597 - Will SSA periodically review the outcome payment system and the outcome-milestone payment system...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....597 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Network Payment Systems § 411.597 Will SSA periodically review the outcome payment system and...

  14. 78 FR 12127 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Department of the Treasury...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-21

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY..., Internal Revenue Service (IRS))--Match Number 1310 AGENCY: Social Security Administration (SSA). ACTION... the General Counsel, Social Security Administration, 617 Altmeyer Building, 6401 Security...

  15. 20 CFR 411.597 - Will SSA periodically review the outcome payment system and the outcome-milestone payment system...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ....597 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Network Payment Systems § 411.597 Will SSA periodically review the outcome payment system and...

  16. Resolving Changing Chemical and Physical Properties of SSA Particle Types during Laboratory Phytoplankton Blooms using Online Single Particle Analysis

    NASA Astrophysics Data System (ADS)

    Sultana, C. M.; Prather, K. A.; Richardson, R.; Wang, X.

    2015-12-01

    Changes in the chemical composition of sea spray aerosols (SSA) can modify their climate-relevant properties. Recent studies have shown a diverse set of distinct SSA particle types, however there are conflicting reports on how and whether biological activity controls the organic fraction and mixing state of SSA. This study leverages an aerosol time-of-flight mass spectrometer to give an accounting of the temporally resolved mixing state of primary SSA (0.4 - 3 µm vacuum aerodynamic diameter), encompassing 97% of particles detected over the course of laboratory phytoplankton blooms. The influence of biological activity on the climate relevant properties of defined particle types is also investigated. Spatial chemical particle heterogeneity and particularly the surface chemical composition of particles are described along with particle type specific water-particle interactions. These online measurements in tandem with chemical composition could give new insight on the link between seawater chemistry, marine aerosols, and climate properties.

  17. 20 CFR 408.1235 - How does the State transfer funds to SSA to administer its recognition payment program?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... ADMINISTRATION SPECIAL BENEFITS FOR CERTAIN WORLD WAR II VETERANS Federal Administration of State Recognition... total amounts paid by SSA on behalf of the State during the current Federal fiscal year; the...

  18. Monte Carlo SSA to detect time-variable seasonal oscillations from GPS-derived site position time series

    NASA Astrophysics Data System (ADS)

    Xu, Chang; Yue, Dongjie

    2015-12-01

    We explore the capability of singular spectrum analysis (SSA) to extract time-variable seasonal oscillations from continual GPS observations and demonstrate the statistical assessment on the colored noise (in particular the first-order autoregressive AR(1) noise) using Monte Carlo SSA (MCSSA) methodology. We provide example applications to 15-year vertical coordinate time series for 36 globally distributed International GNSS Service (IGS) sites. We find the SSA-filtered seasonal signals can easily pass the confidence interval and hypothesis tests of MCSSA. However, maximum likelihood estimate (MLE) results show that 72% of sites have their flicker noise amplitudes reduced after removing SSA-filtered annual signal, implying that the SSA-filtered seasonal signals may contain an artificial signal driven by colored noise. Therefore, the AR(1) null hypothesis noise model may be misleading in surrogate data tests for GPS seasonal signals. Moreover, comparison between SSA-filtered GPS annual signals and joint geophysical model predictions (non-tidal atmospheric loading + non-tidal ocean loading + hydrological loading) confirms that seasonal signals are resulting from a combination of mass loading and systematic error.

  19. Adenocarcinoma arising in small sessile serrated adenoma/polyp (SSA/P) of the colon: clinicopathological study of eight lesions.

    PubMed

    Ban, Shinichi; Mitomi, Hiroyuki; Horiguchi, Hisashi; Sato, Hideaki; Shimizu, Michio

    2014-03-01

    We reviewed the clinicopathological findings of eight cases of sessile serrated adenoma/polyps (SSA/Ps) with carcinoma, the largest diameter of which was 10 mm or less. All lesions were polyps located in the right side of the colon. Four lesions showed submucosal invasion and one lesion invaded the proper muscle layer. The depth of invasion, however, did not seem to be related to the carcinoma area size. Most carcinomas were well to moderately differentiated tubular adenocarcinomas focally showing some serrated appearances, and the predominant component of one carcinoma was a poorly differentiated medullary growth with inflammatory stroma. Rapid progression to invasive carcinoma from SSA/P was suggested for the carcinoma with proper muscle invasion whereas one submucosally invasive carcinoma was considered to progress over 7 years. Immunohistochemically, it was suggested that with or without hMLH1 protein loss, alterations of p53 and/or Wnt signaling pathway can be involved in the cancerization through SSA/Ps. The carcinomas irregularly imitated the mucin expression of the SSA/Ps (positive for MUC5AC and MUC2, and MUC6 expression in crypt bases), which was lost with progression of the carcinomas. Analyses of small SSA/P lesions with cancerization would facilitate the understanding of the mode of progression of SSA/Ps and their early detection. © 2014 The Authors. Pathology International © 2014 Japanese Society of Pathology and Wiley Publishing Asia Pty Ltd.

  20. Development and calibration of an automatic spectral albedometer to estimate near-surface snow SSA time series

    NASA Astrophysics Data System (ADS)

    Picard, Ghislain; Libois, Quentin; Arnaud, Laurent; Verin, Gauthier; Dumont, Marie

    2016-06-01

    Spectral albedo of the snow surface in the visible/near-infrared range has been measured for 3 years by an automatic spectral radiometer installed at Dome C (75° S, 123° E) in Antarctica in order to retrieve the specific surface area (SSA) of superficial snow. This study focuses on the uncertainties of the SSA retrieval due to instrumental and data processing limitations. We find that when the solar zenith angle is high, the main source of uncertainties is the imperfect angular response of the light collectors. This imperfection introduces a small spurious wavelength-dependent trend in the albedo spectra which greatly affects the SSA retrieval. By modeling this effect, we show that for typical snow and illumination conditions encountered at Dome C, retrieving SSA with an accuracy better than 15 % (our target) requires the difference of response between 400 and 1100 nm to not exceed 2 %. Such a small difference can be achieved only by (i) a careful design of the collectors, (ii) an ad hoc correction of the spectra using the actual measured angular response of the collectors, and (iii) for solar zenith angles less than 75°. The 3-year time series of retrieved SSA features a 3-fold decrease every summer which is significantly larger than the estimated uncertainties. This highlights the high dynamics of near-surface SSA at Dome C.

  1. The effect of welfare reform on SSA's disability programs: design of policy evaluation and early evidence.

    PubMed

    Davies, P; Iams, H; Rupp, K

    2000-01-01

    During the past several years, the U.S. social safety net has gone through substantial changes involving an emphasis on personal responsibility and incentives, the shift of certain responsibilities to the states, and new limits on entitlements for benefits. Two pieces of recent legislation affected the Social Security Administration's (SSA's) disability programs. Section 105 of Public Law 104-121, enacted on March 29, 1996, mandated the removal of persons from the Supplemental Security Income (SSI) and Social Security Disability Insurance (DI) rolls for whom drug addiction and alcoholism (DA&A) were material to the determination of disability. It eliminated allowances on the basis of DA&A immediately and required the termination of benefits to all persons receiving benefits at the time of enactment. The other major piece of legislation was the Personal Responsibility and Work Opportunity Reconciliation Act (PRWORA) of 1996, which was later amended by the Balanced Budget Act (BBA) of 1997. PRWORA converted the Aid to Families with Dependent Children (AFDC) program from an open-ended entitlement program into a block grant, Temporary Assistance for Needy Families (TANF), incorporating time limits on the receipt of benefits as well as strict work requirements. PRWORA also tightened child eligibility for SSI, narrowed eligibility for noncitizens, and reduced funding for food stamps. The BBA restored SSI eligibility for noncitizens receiving SSI prior to August 1996 and for legal noncitizens residing in the United States prior to August 1996 who become disabled in the future. SSA designed three studies to assess the effects of this legislation. Two of the studies focused on direct effects on SSA's disabled beneficiary population, targeting drug addicts and alcoholics and SSI children. The third study focused on the indirect effects of PRWORA, particularly the replacement of AFDC with TANF, on SSA's programs. The three studies were tied together by a concern of the

  2. Dan Johnson the mentor

    NASA Astrophysics Data System (ADS)

    McKinley, Richard

    2003-04-01

    I first met Dan Johnson in early 1975 as I was interviewing for an engineering job with Henning von Gierke's bioengineering and bionics laboratory at Wright-Patterson Air Force Base. From the very beginning Dan was always direct and forthright. Over the ensuing next 27 years my knowledge and respect of Dan constantly grew. This presentation will review Dan's technical and personal contributions while at the laboratory at Wright-Patterson Air Force Base. He was instrumental in the development of a national noise exposure criteria with the equal-energy-rule, an accurate single number hearing protector attenuation measure based on ``C-A,'' an impulse noise exposure criteria, a longitudinal study of hearing loss in children, development of noise dosimeters, and description of hearing damage risk from nonoccupational noise exposures such as disco's, bowling alleys, lawn mowers, and school buses. Dan has had a significant effect on my career. I and the many people who knew him at the laboratory miss him greatly.

  3. Elevated IL-1β levels in anti-Ro/SSA connective tissue diseases patients with prolonged corrected QTc interval.

    PubMed

    Pisoni, Cecilia N; Reina, Silvia; Arakaki, Diego; Eimon, Alicia; Carrizo, Carolina; Borda, Enri

    2015-01-01

    Patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) have increased IL-1β levels. IL-1β and other pro-inflammatory cytokines have a modulating activity on cardiac ion channels and have been associated with increased arrhythmic risk in rheumatoid arthritis patients. Likewise, adult patients with connective tissue diseases (CTDs) may have prolonged QTc intervals associated with the presence of anti-Ro/SSA antibodies. Our objective was to evaluate the presence of serum IL-1β in subjects with CTDs, in relation to the presence of anti-Ro/SSA antibodies and QTc interval duration. 12-lead electrocardiograms (ECG) were performed and blood was withdrawn, measuring electrolytes, IL-1β anti-Ro/SSA antibodies by ELISA in 73 patients with CTDs. 55 patients were anti-Ro/SSA positive and 18 were anti-Ro/SSA negative. Patients with anti-Ro/SSA positive antibodies had a significantly greater median IL-1β serum level: 7.29 (range: 0.17-17.3 pg/ml) compared to patients with anti-Ro/SSA negative antibodies whose median was: 1.67 (range 0.55-4.12 pg/ml) p<0.001. The mean QTc interval values obtained in both groups were not significantly different (417.7±23.1 vs. 414.7±21.2, p=0.63). The QTc interval was prolonged in 11 (20%) patients, who were all anti-Ro/SSA positive versus 0 (0 %) in anti-Ro/SSA negative patients p=0.05. Median IL-1β levels were: 8.7 (range: 2.69-15.1 pg/ml) in patients with prolonged QTc interval versus median: 5.0 (range: 0.17-17.3 pg/ml) in those with normal QTc interval values (<440ms) p=0.006. IL-1β is elevated in patients with CTDs that have both anti-Ro/SSA antibodies and prolonged QTc intervals.

  4. Findings from the UK and Canadian Space Situational Awareness (SSA) Experimentation during the Relocation of SKYNET 5A Satellite

    NASA Astrophysics Data System (ADS)

    Ash, A.; Scott, L.; Feline, W.

    2016-09-01

    This paper describes the planning, execution, analysis and lessons identified from a collaborative Space Situational Awareness (SSA) experiment to observe the SKYNET 5A satellite during a series of orbital maneuvers that occurred in the summer of 2015. In March 2015 Airbus Defence and Space (Airbus DS) announced its intention to relocate the SKYNET 5A satellite from the Atlantic to the Asia Pacific region to increase its global coverage; this provided an opportunity to observe this high value asset to explore the challenges and technical solutions related to deep space SSA. Within the UK the Defence Science and Technology Laboratory (Dstl, part of the UK Ministry of Defence) were established as the lead agency to plan the observation campaign utilising operational and emerging experimental SSA capabilities. The campaign was then expanded to involve Canada, the United States and Australia under the auspices of the Combined Space Operations (CSpO) Memorandum of Understanding (MOU) to further explore the coordination of observations between operational systems and potential fusion of data collected using experimental SSA assets. The focus for this paper is the collaborative work between Dstl and Defence Research and Development Canada (DRDC) that featured a period of experimentation to explore methods that enable cross cueing between ground-based and space-based SSA sensors, namely the UK Starbrook facility (located on the island of Cyprus), and NEOSSat/ Sapphire space surveillance satellites located in low-Earth orbit. A number of conclusions and lessons are identified in this paper that seek to inform the wider SSA community on the challenges, potential solutions and benefits of operating a distributed SSA architecture such as the one utilized during this experiment.

  5. Utilisation and Further Development of Space Science Results in the ESA SSA Programme Space Weather Service Network

    NASA Astrophysics Data System (ADS)

    Glover, Alexi; Luntama, Juha-Pekka; Keil, Ralf

    2016-04-01

    ESA SSA Programme is approaching the end of its second period. Service development activities within the current period aim at advancing the SSA SWE Service Network from the initial utilisation of existing European assets toward development of these and new assets together with the associated coordination infrastructure necessary to provide consistently reliable services. The SSA SWE Service Network is based on a federated architecture where service provision is carried out by Expert Service Centres in the Programme Member States with overall coordination and helpdesk functions provided by a central node and coordination centre located at the Space Pole in Brussels, Belgium. The SSA SWE Service Network builds on the wealth of space weather expertise available within the Member States, and consequently, as the network continues to develop, emphasis will continue to be placed on building services based on demonstrated space science advances in key areas such as those highlighted by the COSPAR-ILWS Space Weather Roadmap, published in 2015. Activities supported by programmes including the ESA technology programmes, EC FP7 and H2020 have all demonstrated promising results, and the SSA SWE Network is actively investigating their potential application to SSA SWE Customer Requirements, and in many cases already adopting these as part of the suite of products provided via the Network to its registered users. This presentation will provide an overview of recent advances in the SSA SWE Service Network, emphasising the utilisation of scientific results within a pre-operational context. The presentation will show the layout of the federated Expert Service Centres, highlighting ongoing and upcoming service developments and provide a perspective on the service development plans for the next phase of the programme.

  6. A new instrument to measure the activity profile of elderly shoulder pathology patients: the Senior Shoulder Activity score (SSA score).

    PubMed

    Deranlot, J; Flurin, P-H; Hardy, P; Klouche, S

    2013-12-01

    Whether rotator cuff repair is indicated in an elderly subject depends on the patient's activity profile and functional demand. A Senior Shoulder Activity (SSA) score is described, as a support for indications and analysis of clinical results according to activity level. The SSA score, comprising 4 levels from "sedentary" to "very active", was validated by comparison against a control group of 113 asymptomatic patients. It was included in the protocol of the French Arthroscopy Society's comparative study of repair versus simple decompression in 143 rotator cuff tears. Recovery of activity was assessed according to procedure. At 1-year follow-up, suturing was associated with recovery of previous activity level in 87% of the cases and in 80% for decompression, a non-significant difference. When, however, less active patients (SSA 1 and 2) were contrasted with the more active (SSA 3 and 4), clinical results with suture versus decompression on Constant score showed a greater difference in the SSA 3-4 group. The SSA score is not the same as the activity item of the Constant score, as it assesses the patient's usual activity level, before symptom onset, whereas the Constant item assesses activity at a given moment, independently of the patient's normal activity profile. The Senior Shoulder Activity score is a simple, reproducible complement to the Constant score, revealing differences in clinical results on the latter, according to activity profile. Rotator cuff repair or simple decompression provided recovery of previous SSA activity level in more than 80% of the cases. The difference in clinical results between the two was significantly greater in more active patients. It would seem to follow that suture is more beneficial for more active subjects while simple decompression may be suitable for those with lower functional demand. Copyright © 2013. Published by Elsevier Masson SAS.

  7. Space Environment Forecasting with Neutron Monitors: Establishing a novel service for the ESA SSA Program

    NASA Astrophysics Data System (ADS)

    Papaioannou, Athanasios; Mavromichalaki, Helen; Souvatzoglou, George; Paschalis, Pavlos; Sarlanis, Christos; Dimitroulakos, John; Gerontidou, Maria

    2013-04-01

    High-energy particles released at the Sun during a solar flare or a very energetic coronal mass ejection, result to a significant intensity increase at neutron monitor measurements known as Ground Level Enhancements (GLEs). Due to their space weather impact (i.e. risks and failures at communication and navigation systems, spacecraft electronics and operations, space power systems, manned space missions, and commercial aircraft operations) it is crucial to establish a real-time operational system that would be in place to issue reliable and timely GLE Alerts. Currently, the Cosmic Ray group of the National and Kapodistrian University of Athens is working towards the establishment of a Neutron Monitor Service that will be made available via the Space Weather Portal operated by the European Space Agency (ESA), under the Space Situational Awareness (SSA) Program. To this end, a web interface providing data from multiple Neutron Monitor stations as well as an upgraded GLE Alert will be provided. Both services are now under testing and validation and they will probably enter to an operational phase next year. The core of this Neutron Monitor Service is the GLE Alert software, and therefore, the main goal of this research effort is to upgrade the existing GLE Alert software, to minimize the probability of a false alarm and to enhance the usability of the corresponding results. The ESA Neutron Monitor Service is building upon the infrastructure made available with the implementation of the High-Resolution Neutron Monitor Database (NMDB). In this work the structure of the Neutron Monitor Service for ESA SSA Program and the impact of the novel GLE Alert Service that will be made available to future users via ESA SSA web portal will be presented and further discussed.

  8. Overview of Human-Centric Space Situational Awareness (SSA) Science and Technology (S&T)

    NASA Astrophysics Data System (ADS)

    Ianni, J.; Aleva, D.; Ellis, S.

    2012-09-01

    A number of organizations, within the government, industry, and academia, are researching ways to help humans understand and react to events in space. The problem is both helped and complicated by the fact that there are numerous data sources that need to be planned (i.e., tasked), collected, processed, analyzed, and disseminated. A large part of the research is in support of the Joint Space Operational Center (JSpOC), National Air and Space Intelligence Center (NASIC), and similar organizations. Much recent research has been specifically targeting the JSpOC Mission System (JMS) which has provided a unifying software architecture. This paper will first outline areas of science and technology (S&T) related to human-centric space situational awareness (SSA) and space command and control (C2) including: 1. Object visualization - especially data fused from disparate sources. Also satellite catalog visualizations that convey the physical relationships between space objects. 2. Data visualization - improve data trend analysis as in visual analytics and interactive visualization; e.g., satellite anomaly trends over time, space weather visualization, dynamic visualizations 3. Workflow support - human-computer interfaces that encapsulate multiple computer services (i.e., algorithms, programs, applications) into a 4. Command and control - e.g., tools that support course of action (COA) development and selection, tasking for satellites and sensors, etc. 5. Collaboration - improve individuals or teams ability to work with others; e.g., video teleconferencing, shared virtual spaces, file sharing, virtual white-boards, chat, and knowledge search. 6. Hardware/facilities - e.g., optimal layouts for operations centers, ergonomic workstations, immersive displays, interaction technologies, and mobile computing. Secondly we will provide a survey of organizations working these areas and suggest where more attention may be needed. Although no detailed master plan exists for human

  9. Swarm Utilisation Analysis: LEO satellite observations for the ESA's SSA Space Weather network

    NASA Astrophysics Data System (ADS)

    Kervalishvili, Guram; Stolle, Claudia; Rauberg, Jan; Olsen, Nils; Vennerstrøm, Susanne; Gullikstad Johnsen, Magnar; Hall, Chris

    2017-04-01

    ESA's (European Space Agency) constellation mission Swarm was successfully launched on 22 November 2013. The three satellites achieved their final constellation on 17 April 2014 and since then Swarm-A and Swarm-C orbiting the Earth at about 470 km (flying side-by-side) and Swarm-B at about 520 km altitude. Each of Swarm satellite carries instruments with high precision to measure magnetic and electric fields, neutral and plasma densities, and TEC (Total Electron Content) for which a dual frequency GPS receiver is used. SUA (Swarm Utilisation Analysis) is a project of the ESA's SSA (Space Situational Awareness) SWE (Space Weather) program. Within this framework GFZ (German Research Centre for Geosciences, Potsdam, Germany) and DTU (National Space Institute, Kongens Lyngby, Denmark) have developed two new Swarm products ROT (Rate Of change of TEC) and PEJ (Location and intensity level of Polar Electrojets), respectively. ROT is derived as the first time derivative from the Swarm measurements of TEC at 1 Hz sampling. ROT is highly relevant for users in navigation and communications: strong plasma gradients cause GPS signal degradation or even loss of GPS signal. Also, ROT is a relevant space weather asset irrespective of geomagnetic activity, e.g., high amplitude values of ROT occur during all geomagnetic conditions. PEJ is derived from the Swarm measurements of the magnetic field strength at 1 Hz sampling. PEJ has a high-level importance for power grid companies since the polar electrojet is a major cause for ground-induced currents. ROT and PEJ together with five existing Swarm products TEC, electron density, IBI (Ionospheric Bubble Index), FAC (Field-Aligned Current), and vector magnetic field build the SUA service prototype. This prototype will be integrated into ESA's SSA Space Weather network as a federated service and will be available soon from ESA's SSA SWE Ionospheric Weather and Geomagnetic Conditions Expert Service Centres (ESCs).

  10. Indirect immunofluorescence on HEp-2000 substrate is a sensitive method for detecting anti-Ro/SSA antibodies in patients with lupus erythematosus and/or photosensitivity.

    PubMed

    Cozzani, Emanuele; Drosera, Massimo; Siccardi, Marina; Babbini, Giovanni; Parodi, Aurora

    2008-07-01

    To evaluate the sensitivity of indirect immunofluorescence (IIF) utilizing HEp-2000 cells to detect antinuclear and anti-Ro/SSA antibodies. We examined 5949 sera samples from 2316 patients with connective tissue diseases. All sera were tested by IIF on HEp-2 cells as substrate and by counterimmunoelectrophoresis (CIE). The positive sera for anti-Ro/SSA antibodies by CIE were retested by IIF using HEp-2000 cells. The sera that were anti-Ro/SSA-positive in CIE but negative on HEp-2000 cells were tested by ELISA for the 60 and 52 subunits of Ro/SSA antigen. Our results confirm the high sensitivity (81%) of HEp-2000 cells in detecting anti Ro/SSA antibodies. Using the HEp-2000 substrate is a reliable, simple alternative method for detecting anti-Ro/SSA antibodies in a first-level screening test such as IIF, especially in patients with lupus erythematosus and/or photosensitivity.

  11. BOREAS Elevation Contours over the NSA and SSA in ARC/INFO Generate Format

    NASA Technical Reports Server (NTRS)

    Knapp, David; Nickeson, Jaime; Hall, Forrest G. (Editor)

    2000-01-01

    This data set was prepared by BORIS Staff by reformatting the original data into the ARC/INFO Generate format. The original data were received in SIF at a scale of 1:50,000. BORIS staff could not find a format document or commercial software for reading SIF; the BOREAS HYD-08 team pro-vided some C source code that could read some of the SIF files. The data cover the BOREAS NSA and SSA. The original data were compiled from information available in the 1970s and 1980s. The data are available in ARC/INFO Generate format files.

  12. Substructure within the SSA22 Protocluster at z≈3.09

    NASA Astrophysics Data System (ADS)

    Topping, Michael W.; Shapley, Alice E.; Steidel, Charles C.

    2016-06-01

    We present the results of a densely sampled spectroscopic survey of the SSA22 protocluster at z ≈ 3.09. Our sample with Keck/LRIS spectroscopy includes 106 Lyα emitters (LAEs) and 40 Lyman break galaxies (LBGs) at z = 3.05-3.12. These galaxies are contained within the 9‧ × 9‧ region in which the protocluster was discovered, which also hosts the maximum galaxy overdensity in the SSA22 region. The redshift histogram of our spectroscopic sample reveals two distinct peaks, at z = 3.069 (blue; 43 galaxies) and z = 3.095 (red; 103 galaxies). Furthermore, objects in the blue and red peaks are segregated on the sky, with galaxies in the blue peak concentrating toward the western half of the field. These results suggest that the blue and red redshift peaks represent two distinct structures in physical space. Although the double-peaked redshift histogram is traced in the same manner by LBGs and LAEs, and brighter and fainter galaxies, we find that 9 out of 10 X-ray AGNs in SSA22, and all 7 spectroscopically confirmed giant Lyα “blobs,” reside in the red peak. We combine our data set with sparsely sampled spectroscopy from the literature over a significantly wider area, finding preliminary evidence that the double-peaked structure in redshift space extends beyond the region of our dense spectroscopic sampling. In order to fully characterize the three-dimensional structure, dynamics, and evolution of large-scale structure in the SSA22 overdensity, we require the measurement of large samples of LAE and LBG redshifts over a significantly wider area, as well as detailed comparisons with cosmological simulations of massive cluster formation. Based on data obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration, and was made possible by the generous financial support of the W.M. Keck Foundation.

  13. BOREAS Forest Cover Data Layers over the SSA-MSA in Raster Format

    NASA Technical Reports Server (NTRS)

    Nickeson, Jaime; Gruszka, F; Hall, F.

    2000-01-01

    This data set, originally provided as vector polygons with attributes, has been processed by BORIS staff to provide raster files that can be used for modeling or for comparison purposes. The original data were received as ARC/INFO coverages or as export files from SERM. The data include information on forest parameters for the BOREAS SSA-MSA. Most of the data used for this product were acquired by BORIS in 1993; the maps were produced from aerial photography taken as recently as 1988. The data are stored in binary, image format files.

  14. BOREAS Soils Data over the SSA in Raster Format and AEAC Projection

    NASA Technical Reports Server (NTRS)

    Knapp, David; Rostad, Harold; Hall, Forrest G. (Editor)

    2000-01-01

    This data set consists of GIS layers that describe the soils of the BOREAS SSA. The original data were submitted as vector layers that were gridded by BOREAS staff to a 30-meter pixel size in the AEAC projection. These data layers include the soil code (which relates to the soil name), modifier (which also relates to the soil name), and extent (indicating the extent that this soil exists within the polygon). There are three sets of these layers representing the primary, secondary, and tertiary soil characteristics. Thus, there is a total of nine layers in this data set along with supporting files. The data are stored in binary, image format files.

  15. BOREAS TF-8 NSA-OJP and SSA-OBS Ceilometer Data

    NASA Technical Reports Server (NTRS)

    Moore, Kathleen E.; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor); Fitzjarrald, David R.

    2000-01-01

    The BOREAS TF-8 team used ceilometers to collect data on the fraction of the sky covered with clouds and the cloud height. Included with these data is the surface-based lifting condensation level, derived from temperature and humidity values acquired at the flux tower at the NSA-OJP site. Ceilo-meter data were collected at the NSA-OJP site in 1994 and at the NSA-OJP and SSA-OBS sites in 1996. The data are available in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884).

  16. MELiSSA third compartment: Nitrosomonas europaea and Nitrobacter winogradskyi axenic cultures in bioreactors

    NASA Astrophysics Data System (ADS)

    Cruvellier, Nelly; Lasseur, Christophe; Poughon, Laurent; Creuly, Catherine; Dussap, Gilles

    Nitrogen is a key element for the life and its balance on Earth is regulated by the nitrogen cycle. This loop includes several steps among which nitrification that permits the transformation of the ammonium into nitrate. The MELiSSA loop is an artificial ecosystem designed for life support systems (LSS). It is based on the carbon and nitrogen cycles and the recycling of the non-edible part of the higher plants and the waste produced by the crew. In this order, all the wastes are collected in the first compartment to degrade them into organic acids and CO2. These compounds are joining the second compartment which is a photoheterotrophic compartment where at the outlet an organic-free medium containing ammonium is produced. This solution will be the substrate of the third compartment where nitrification is done. This compartment has to oxidize the ammonium into nitrate, and this biological reaction needs two steps. In the MELiSSA loop, the nitrification is carried out by two bacteria: Nitrosomonas europaea ATCC® 19718™ which is oxidizing ammonia into nitrite and Nitrobacter winogradskyi ATCC® 25391™ which is producing nitrate from nitrite in the third compartment. These two bacteria are growing in axenic conditions on a fixed bed bioreactor filled with Biostyr® beads. The nitrogen compounds are controlled by Ionic Chromatography and colorimetric titration for each sample. The work presented here deals with the culture of both bacteria in pure cultures and mixed cultures in stirred and aerated bioreactors of different volumes. The first aim of our work is the characterization of the bacteria growth in bioreactors and in the nitrifying fixed-bed column. The experimental results confirm that the growth is slow; the maximal growth rate in suspended cultures is 0.054h-1 for Nitrosomonas europaea and 0.022h-1 for Nitrobacter winogradskyi. Mixed cultures are difficult to control and operate but one could be done for more than 500 hours. The characterization of the

  17. BOREAS RSS-7 Landsat TM LAI IMages of the SSA and NSA

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Chen, Jing; Cihlar, Josef

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Remote Sensing Science (BOREAS RSS-7) team used Landsat Thematic Mapper (TM) images processed at CCRS to produce images of Leaf Area Index (LAI) for the BOREAS study areas. Two images acquired on 06-Jun and 09-Aug-1991 were used for the SSA, and one image acquired on 09-Jun-1994 was used for the NSA. The LAI images are based on ground measurements and Landsat TM Reduced Simple Ratio (RSR) images. The data are stored in binary image-format files.

  18. BOREAS TF-2 SSA-OA Tower Flux, Meteorological, and Precipitation Data

    NASA Technical Reports Server (NTRS)

    Neumann, Harold; Mickle, Robert; Staebler, Ralf; Hall, Forrest G. (Editor); Huemmrich, Karl (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux-2 (BOREAS TF-2) team collected energy, carbon dioxide, water vapor, and momentum flux data above the canopy and in profiles through the canopy, along with meteorological data at the BOREAS Southern Study Area-Old Aspen (SSA-OA) site. Above-canopy measurements began in early February and ran through mid-September of 1994. Measurements were collected over a longer period of 1994 than most BOREAS flux sites. Daily precipitation data from several gauges were also collected. The data are available in tabular ASCII files.

  19. Rapid detection of contaminating bacteria in the Rhodospirillum rubrum bioreactor of the life support system MELiSSA

    NASA Astrophysics Data System (ADS)

    Hendrickx, L.; Janssen, P.; Baatout, S.; Wattiez, R.; van Havermaet, A.; Bossi, V.; Mergeay, M.

    For a lunar base or a mission to Mars a reliable life support system is essential to replenish the food and water supplies and manage the production of gases and wastes MELiSSA Micro Ecological Life Support System is a model of regenerative life support system targeting complete recycling of gas liquids and solid wastes by using the combined activity of different living organisms i e microbial communities in 4 succesive microbial bioreactors CI CII CIII CIVa a plant compartment and a human crew http www estec esa nl ecls In order for the MELiSSA system to function properly the organisms inhabiting the MELiSSA loop need to perform their tasks as optimally as possible One important aspect is to control the axenicity of the MELISSA compartments CII CIII CIVa because contaminants constitute a major concern in the proper functioning and maintenance of a closed artificial ecosystem The first compartment of the MELiSSA loop wherein the organic waste is liquefied by a bacterial consortium originating from the waste itself is a likely source of pathogens Hence the second compartment in which R rubrum converts the in CI produced volatile fatty acids into minerals and biomass is probably an axenically vulnerable compartment within the MELiSSA loop due to its direct link with the first compartment Methods to check any loss of axenicity in the compartment of R rubrum are presented and evaluated in the present communication Flow cytometry in combination with specific fluorescent probes matrix assisted laser

  20. Effect of lime addition during sewage sludge treatment on characteristics of resulting SSA when it is used in cementitious materials.

    PubMed

    Vouk, D; Nakic, D; Štirmer, N; Baricevic, A

    2017-02-01

    Final disposal of sewage sludge is important not only in terms of satisfying the regulations, but the aspect of choosing the optimal wastewater treatment technology, including the sludge treatment. In most EU countries, significant amounts of stabilized and dewatered sludge are incinerated, and sewage sludge ash (SSA) is generated as a by product. At the same time, lime is one of the commonly used additives in the sewage sludge treatment primarily to stabilize the sludge. In doing so, the question arose how desirable is such addition of lime if the sludge is subsequently incinerated, and the generated ash is further used in the production of cementitious materials. A series of mortars were prepared where 10-20% of the cement fraction was replaced by SSA. Since all three types of analyzed SSA (without lime, with lime added during sludge stabilization and with extra lime added during sludge incineration) yielded nearly same results, it can be concluded that if sludge incineration is accepted solution, lime addition during sludge treatment is unnecessary even from the standpoint of preserving the pozzolanic properties of the resulting SSA. Results of the research carried out on cement mortars point to the great possibilities of using SSA in concrete industry.

  1. BOREAS TE-1 CO2 and CH4 Flux Data Over the SSA-OBS Site

    NASA Technical Reports Server (NTRS)

    Anderson, Darwin; Papagno, Andrea; Hall, Forrest G. (Editor); Newcomer, Jeffrey A. (Editor)

    2000-01-01

    The BOREAS TE-1 team collected various data to characterize the soil-plant systems in the BOREAS SSA. Particular emphasis was placed on nutrient biochemistry, the stores and transfers of organic carbon, and how the characteristics were related to measured methane fluxes. The overall transect in the Prince Albert National Park (Saskatchewan, Canada) included the major plant communities and related soils that occurred in that section of the boreal forest. Soil physical, chemical, and biological measurements along the transect were used to characterize the static environment, which allowed them to be related to methane fluxes. Chamber techniques were used to provide a measure of methane production/uptake. Chamber measurements coupled with flask sampling were used to determine the seasonality of methane fluxes. This particular data set contains carbon dioxide and methane flux values from the SSA-OBS site. The data were collected from 09-Jun to 04-Sep-1994. The data are stored in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  2. BOREAS TE-1 CH4 Flux Data Over The SSA-OA

    NASA Technical Reports Server (NTRS)

    Anderson, Darwin; Papagno, Andrea; Hall, Forrest G. (Editor); Newcomer, Jeffrey A. (Editor)

    2000-01-01

    The BOREAS TE-1 team collected various data to characterize the soil-plant systems in the BOREAS SSA. Particular emphasis was placed on nutrient biochemistry, the stores and transfers of organic carbon, and how the characteristics were related to measured methane fluxes. The overall transect in the Prince Albert National Park (Saskatchewan, Canada) included the major plant communities and related soils that occurred in that section of the boreal forest. Soil physical, chemical, and biological measurements along the transect were used to characterize the static environment, which allowed them to be related to methane fluxes. Chamber techniques were used to provide a measure of methane production/uptake. Chamber measurements coupled with flask sampling were used to determine the seasonality of methane fluxes. This particular data set contains methane flux and soil profile methane concentration values from the SSA-OA site. The data were collected from 29-May to 17-Sep-1994. The data are stored in tabular ASCII files. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  3. Solar Flare Prediction Science-to-Operations: the ESA/SSA SWE A-EFFort Service

    NASA Astrophysics Data System (ADS)

    Georgoulis, Manolis K.; Tziotziou, Konstantinos; Themelis, Konstantinos; Magiati, Margarita; Angelopoulou, Georgia

    2016-07-01

    We attempt a synoptical overview of the scientific origins of the Athens Effective Solar Flare Forecasting (A-EFFort) utility and the actions taken toward transitioning it into a pre-operational service of ESA's Space Situational Awareness (SSA) Programme. The preferred method for solar flare prediction, as well as key efforts to make it function in a fully automated environment by coupling calculations with near-realtime data-downloading protocols (from the Solar Dynamics Observatory [SDO] mission), pattern recognition (solar active-region identification) and optimization (magnetic connectivity by simulated annealing) will be highlighted. In addition, the entire validation process of the service will be described, with its results presented. We will conclude by stressing the need for across-the-board efforts and synergistic work in order to bring science of potentially limited/restricted interest into realizing a much broader impact and serving the best public interests. The above presentation was partially supported by the ESA/SSA SWE A-EFFort project, ESA Contract No. 4000111994/14/D/MRP. Special thanks go to the ESA Project Officers R. Keil, A. Glover, and J.-P. Luntama (ESOC), M. Bobra and C. Balmer of the SDO/HMI team at Stanford University, and M. Zoulias at the RCAAM of the Academy of Athens for valuable technical help.

  4. Characterizing the Space Debris Environment with a Variety of SSA Sensors

    NASA Technical Reports Server (NTRS)

    Stansbery, Eugene G.

    2010-01-01

    Damaging space debris spans a wide range of sizes and altitudes. Therefore no single method or sensor can fully characterize the space debris environment. Space debris researchers use a variety of radars and optical telescopes to characterize the space debris environment in terms of number, altitude, and inclination distributions. Some sensors, such as phased array radars, are designed to search a large volume of the sky and can be instrumental in detecting new breakups and cataloging and precise tracking of relatively large debris. For smaller debris sizes more sensitivity is needed which can be provided, in part, by large antenna gains. Larger antenna gains, however, produce smaller fields of view. Statistical measurements of the debris environment with less precise orbital parameters result. At higher altitudes, optical telescopes become the more sensitive instrument and present their own measurement difficulties. Space Situational Awareness, or SSA, is concerned with more than the number and orbits of satellites. SSA also seeks to understand such parameters as the function, shape, and composition of operational satellites. Similarly, debris researchers are seeking to characterize similar parameters for space debris to improve our knowledge of the risks debris poses to operational satellites as well as determine sources of debris for future mitigation. This paper will discuss different sensor and sensor types and the role that each plays in fully characterizing the space debris environment.

  5. Batch Model for Batched Timestamps Data Analysis with Application to the SSA Disability Program.

    PubMed

    Yue, Qingqi; Yuan, Ao; Che, Xuan; Huynh, Minh; Zhou, Chunxiao

    2016-08-01

    The Office of Disability Adjudication and Review (ODAR) is responsible for holding hearings, issuing decisions, and reviewing appeals as part of the Social Security Administration's disability determining process. In order to control and process cases, the ODAR has established a Case Processing and Management System (CPMS) to record management information since December 2003. The CPMS provides a detailed case status history for each case. Due to the large number of appeal requests and limited resources, the number of pending claims at ODAR was over one million cases by March 31, 2015. Our National Institutes of Health (NIH) team collaborated with SSA and developed a Case Status Change Model (CSCM) project to meet the ODAR's urgent need of reducing backlogs and improve hearings and appeals process. One of the key issues in our CSCM project is to estimate the expected service time and its variation for each case status code. The challenge is that the systems recorded job departure times may not be the true job finished times. As the CPMS timestamps data of case status codes showed apparent batch patterns, we proposed a batch model and applied the constrained least squares method to estimate the mean service times and the variances. We also proposed a batch search algorithm to determine the optimal batch partition, as no batch partition was given in the real data. Simulation studies were conducted to evaluate the performance of the proposed methods. Finally, we applied the method to analyze a real CPMS data from ODAR/SSA.

  6. Characterizing the Space Debris Environment with a Variety of SSA Sensors

    NASA Astrophysics Data System (ADS)

    Stansbery, Eugene

    Damaging space debris spans a wide range of sizes and altitudes. Therefore no single method or sensor can fully characterize the space debris environment. Space debris researchers use a variety of radars and optical telescopes to characterize the space debris environment in terms of number, altitude, and inclination distributions. Some sensors, such as phased array radars, are designed to search a large volume of the sky and can be instrumental in detecting new breakups and cataloging and precise tracking of relatively large debris. For smaller debris sizes more sensitivity is needed which can be provided, in part, by large antenna gains. Larger antenna gains, however, produce smaller fields of view. Statistical measurements of the debris environment with less precise orbital parameters result. At higher altitudes, optical telescopes become the more sensitive instrument and present their own measurement difficulties. Space Situational Awareness, or SSA, is concerned with more than the number and orbits of satellites. SSA also seeks to understand such parameters as the function, shape, and compo-sition of operational satellites. Similarly, debris researchers are seeking to characterize similar parameters for space debris to improve our knowledge of the risks debris poses to operational satellites as well as determine sources of debris for future mitigation. This paper will discuss different sensor and sensor types and the role that each plays in fully characterizing the space debris environment.

  7. Spatial correlation between submillimetre and Lyman-alpha galaxies in the SSA 22 protocluster.

    PubMed

    Tamura, Yoichi; Kohno, Kotaro; Nakanishi, Kouichiro; Hatsukade, Bunyo; Iono, Daisuke; Wilson, Grant W; Yun, Min S; Takata, Tadafumi; Matsuda, Yuichi; Tosaki, Tomoka; Ezawa, Hajime; Perera, Thushara A; Scott, Kimberly S; Austermann, Jason E; Hughes, David H; Aretxaga, Itziar; Chung, Aeree; Oshima, Tai; Yamaguchi, Nobuyuki; Tanaka, Kunihiko; Kawabe, Ryohei

    2009-05-07

    Lyman-alpha emitters are thought to be young, low-mass galaxies with ages of approximately 10(8) yr (refs 1, 2). An overdensity of them in one region of the sky (the SSA 22 field) traces out a filamentary structure in the early Universe at a redshift of z approximately 3.1 (equivalent to 15 per cent of the age of the Universe) and is believed to mark a forming protocluster. Galaxies that are bright at (sub)millimetre wavelengths are undergoing violent episodes of star formation, and there is evidence that they are preferentially associated with high-redshift radio galaxies, so the question of whether they are also associated with the most significant large-scale structure growing at high redshift (as outlined by Lyman-alpha emitters) naturally arises. Here we report an imaging survey of 1,100-microm emission in the SSA 22 region. We find an enhancement of submillimetre galaxies near the core of the protocluster, and a large-scale correlation between the submillimetre galaxies and the low-mass Lyman-alpha emitters, suggesting synchronous formation of the two very different types of star-forming galaxy within the same structure at high redshift. These results are in general agreement with our understanding of the formation of cosmic structure.

  8. SSA Building Blocks - Transforming Your Data and Applications into Operational Capability

    NASA Astrophysics Data System (ADS)

    Buell, D.; Hawthorne, Shayn, L.; Higgins, J.

    The Electronic System Center's 850 Electronic Systems Group (ELSG) is currently using a Service Oriented Architecture (SOA) to rapidly create net-centric experimental prototypes. This SOA has been utilized effectively across diverse mission areas, such as global air operations and rapid sensor tasking for improved space event management. The 850 ELSG has deployed a working, accredited, SOA on the SIPRNET and provided real-time space information to five separate distributed operations centers. The 850 ELSG has learned first-hand the power of SOAs for integrating DoD and non-DoD SSA data in a rapid and agile manner, allowing capabilities to be fielded and sensors to be integrated in weeks instead of months. This opens a world of opportunity to integrate University data and experimental or proof-of-concept data with sensitive sensors and sources to support developing an array of SSA products for approved users in and outside of the space community. This paper will identify how new capabilities can be proactively developed to rapidly answer critical needs when SOA methodologies are employed and identifies the operational utility and the far-reaching benefits realized by implementing a service-oriented architecture. We offer a new paradigm for how data and application producer's contributions are presented for the rest of the community to leverage.

  9. Isolated anti-Ro/SSA thrombocytopenia: a rare feature of neonatal lupus.

    PubMed

    Ayadi, Imene Dahmane; Ben Hamida, Emira; Boukhris, Mohamed Riadh; Bezzine, Ahlem; Chaouachi, Sihem; Marrakchi, Zahra

    2015-01-01

    We report a rare case of isolated thrombocytopenia related to anti-Ro/SSA antibodies. The mother was followed for unlabeled familial thrombocytopenia. The mother had positive anti-Ro/SSA antibodies. She was asymptomatic without skin lesions or other criteria neither of systemic lupus erythematosus nor other connective tissue disease. Pregnancy was uneventful. The postnatal examination was normal. On the first day of life, blood cells count showed thrombocytopenia at 40 x 10(9)/L. Within the second day of life, platelet level dropped to 20 x 10(9)/L. The management of thrombocytopenia included platelet transfusion and human immunoglobulin infusion. On the fifth day of life, there has been a drop in platelet count to 10 x 10(9)/L requiring renewed platelet transfusion and human immunoglobulin infusion. On the 10(th) of life platelets rate was stable around 60 x 10(9)/L. The infant had no evidence of cardiac, dermatologic or hepatobilary involvement initially or throughout follow up.

  10. Acquired Gitelman Syndrome in an Anti-SSA Antibody-positive Patient with a SLC12A3 Heterozygous Mutation

    PubMed Central

    Kusuda, Takeshi; Hosoya, Tadashi; Mori, Takayasu; Ihara, Katsuhito; Nishida, Hidenori; Chiga, Motoko; Sohara, Eisei; Rai, Tatemitsu; Koike, Ryuji; Uchida, Shinichi; Kohsaka, Hitoshi

    2016-01-01

    A 36-year-old woman developed hypokalemic metabolic alkalosis after anti SS-A antibody was found to be positive. Diuretic loading test results were compatible with Gitelman syndrome (GS). The patient had a heterozygous mutation in SLC12A3, which encodes for thiazide-sensitive NaCl cotransporter (NCCT). While the mutation may be responsible for a latent hypofunction of NCCTs, the underlying anti-SSA antibody-associated autoimmunity induced the manifestation of its hypofunction. To the best of our knowledge, this is the first report to demonstrate that anti SS-A antibody-associated autoimmunity may induce GS in a patient with a SLC12A3 heterozygous mutation. PMID:27803420

  11. Isotype switching and titer variation of anti-Ro/SSA antibodies over time in 100 patients with undifferentiated connective tissue disease (UCTD).

    PubMed

    Ceribelli, A; Cavazzana, I; Franceschini, F; Quinzanini, M; Rizzini, F Lodi; Cattaneo, R

    2008-01-01

    To correlate the clinical course of the disease with the titer, the isotype profile and the switch of the anti-Ro/SSA antibodies in a cohort of patients affected by UCTD. One hundred selected patients with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis (CIE), and affected by UCTD with a mean follow-up of 7.6 years (SD 4.8 yrs.), were studied. The titer of IgA, IgG and IgM anti-Ro/SSA antibodies was determined in two different sera, obtained at the time of diagnosis and at the last visit, by ELISA with Ro/SSA recombinant proteins as substrate. Thirty-five patients evolved from UCTD to a different connective tissue disease, while 65 showed a stable disease. Anti-Ro/SSA antibodies were detected in 91% and 97% of the patients, at baseline and during follow-up, respectively. IgG dominates the anti-Ro response. The titer of IgA, IgM and IgG anti-Ro/SSA did not differ significantly between the two groups of patients with UCTD. An increasing trend of IgG and IgA anti-Ro/SSA titer could be detected in patients evolving in primary Sjögren's Syndrome (pSS), but only the increase of IgG anti-Ro/SSA was significant (p=0.0235). IgG dominates the anti-Ro/SSA response in patients with UCTD. No substantial change of the antibody isotype against Ro/SSA peptides could be observed during follow-up. The titer of IgG anti-Ro/SSA significantly raised in the group of patients evolving in pSS.

  12. Cellular mechanism of the conduction abnormalities induced by serum from anti-Ro/SSA-positive patients in rabbit hearts.

    PubMed Central

    Garcia, S; Nascimento, J H; Bonfa, E; Levy, R; Oliveira, S F; Tavares, A V; de Carvalho, A C

    1994-01-01

    In this study, IgG fractions from sera of SLE patients with anti-Ro/SSA or anti-Ro/SSA and anti-La/SSB activity were tested in Langendorff preparations of adult rabbit hearts, aiming to reproduce the cardiac manifestations observed in neonatal lupus in an experimental model. The hearts were perfused with normal Tyrode's solution for 30 min, followed by perfusion with Tyrode's containing 0.3 mg/ml of anti-Ro/SSA- (or anti-Ro/La-) positive IgG (nine sera), anti-ribonucleoprotein (RNP)-positive IgG (five sera), or IgG fractions from normal donors (five sera). In one third of the experiments done with anti-Ro/La-positive IgG, heart block was observed. With the remaining fractions, a decrease in heart rate of 17.1% was observed, but normal sinus rhythm was maintained. The IgG fractions with anti-RNP activity (five experiments) and from normal sera (six experiments) reduced heart rates by 12.9 and 3.3%, respectively, but heart block was not observed. To further characterize the cellular mechanisms involved in the conduction disturbances observed in the whole rabbit hearts, we conducted experiments with ventricular myocytes isolated from young rabbit hearts, studied by whole cell patch-clamp technique. In these experiments, the slow inward currents were analyzed during the superfusion of the cell with normal Tyrode's solution and 5 min after superfusion with Tyrode's solution containing 0.3 mg/ml of anti-Ro/SSA- (or anti-Ro/La-) positive IgG (five sera), anti-RNP-positive IgG (three sera), or IgG from normal donors (four sera). Resting and action potential amplitudes were not affected by any of the sera used. The anti-Ro/SSA IgG fraction induced a mean reduction in the peak slow inward current of 31.6%. IgG fractions with anti-RNP activity reduced slow inward current by 4.4%, whereas IgG fractions from normal donors increased this current by 3.3%. IgG-free fractions from sera of patients with anti-Ro/SSA activity did not alter the peak slow inward current. These results

  13. Ultrasound findings in fetal congenital heart block associated with maternal anti-Ro/SSA and Anti-La/SSB antibodies.

    PubMed

    Lai, Jasmine; Clark, Toshi J; Tan, Justin H; Delaney, Shani; Jolley, Jennifer A

    2015-03-01

    We present the sonographic features of a second-trimester fetus diagnosed with a bradyarrhythmia at 19 weeks' gestation. The mother carried a diagnosis of Sjögren syndrome, including the presence of SSA and SSB antibodies. Ultrasound M-mode and fetal echocardiogram revealed the etiology of the bradycardia to be a complete fetal congenital heart block, likely due to transplacental passage of autoimmune anti-Ro/SSA and anti-La/SSB antibodies. Consequential to the congenital heart block, the fetus developed hydrops fetalis at 21 weeks' gestational age. We discuss the 2 major etiologies of congenital heart block and the implications in subsequent pregnancies.

  14. Ductal constriction during dexamethasone treatment in an anti-SSA-antibody-exposed fetus with signs of myocardial inflammation.

    PubMed

    Talemal, Lauren; Olivieri, Laura; Krishnan, Anita

    2016-06-01

    This report describes the clinical course and multi-modality imaging findings in an anti-SSA-antibody-exposed fetus with suspected myocardial inflammation. Postnatal cardiac MRI - using fast acquisition, free-breathing with feed-and-swaddle technique - was used to evaluate for myocardial fibrosis/inflammation. This is the first published report, to our knowledge, of ductal constriction temporally associated with oral dexamethasone therapy in an anti-SSA-antibody-exposed fetus and of the use of this unique postnatal MRI protocol in this setting.

  15. The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukaemia cells through downregulation of Mcl-1.

    PubMed

    Larrayoz, M; Blakemore, S J; Dobson, R C; Blunt, M D; Rose-Zerilli, M J J; Walewska, R; Duncombe, A; Oscier, D; Koide, K; Forconi, F; Packham, G; Yoshida, M; Cragg, M S; Strefford, J C; Steele, A J

    2016-02-01

    The pro-survival Bcl-2 family member Mcl-1 is expressed in chronic lymphocytic leukaemia (CLL), with high expression correlated with progressive disease. The spliceosome inhibitor spliceostatin A (SSA) is known to regulate Mcl-1 and so here we assessed the ability of SSA to elicit apoptosis in CLL. SSA induced apoptosis of CLL cells at low nanomolar concentrations in a dose- and time-dependent manner, but independently of SF3B1 mutational status, IGHV status and CD38 or ZAP70 expression. However, normal B and T cells were less sensitive than CLL cells (P=0.006 and P<0.001, respectively). SSA altered the splicing of anti-apoptotic MCL-1(L) to MCL-1(s) in CLL cells coincident with induction of apoptosis. Overexpression studies in Ramos cells suggested that Mcl-1 was important for SSA-induced killing since its expression inversely correlated with apoptosis (P=0.001). IL4 and CD40L, present in patient lymph nodes, are known to protect tumour cells from apoptosis and significantly inhibited SSA, ABT-263 and ABT-199 induced killing following administration to CLL cells (P=0.008). However, by combining SSA with the Bcl-2/Bcl-x(L) antagonists ABT-263 or ABT-199, we were able to overcome this pro-survival effect. We conclude that SSA combined with Bcl-2/Bcl-x(L) antagonists may have therapeutic utility for CLL.

  16. 20 CFR 411.226 - How will SSA determine if I am meeting the timely progress guidelines if I assign my ticket prior...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false How will SSA determine if I am meeting the timely progress guidelines if I assign my ticket prior to July 21, 2008? 411.226 Section 411.226... § 411.226 How will SSA determine if I am meeting the timely progress guidelines if I assign my ticket...

  17. 2 CFR 2336.137 - Who in the SSA may grant an exception to let an excluded person participate in a covered...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Who in the SSA may grant an exception to let an excluded person participate in a covered transaction? 2336.137 Section 2336.137 Grants and... DEBARMENT AND SUSPENSION General § 2336.137 Who in the SSA may grant an exception to let an excluded person...

  18. 20 CFR 411.226 - How will SSA determine if I am meeting the timely progress guidelines if I assign my ticket prior...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false How will SSA determine if I am meeting the timely progress guidelines if I assign my ticket prior to July 21, 2008? 411.226 Section 411.226... § 411.226 How will SSA determine if I am meeting the timely progress guidelines if I assign my ticket...

  19. Low titer, isolated anti Ro/SSA 60 kd antibodies is correlated with positive pregnancy outcomes in women at risk of congenital heart block.

    PubMed

    Tonello, Marta; Hoxha, Ariela; Mattia, Elena; Zambon, Alessandra; Visentin, Silvia; Cerutti, Alessia; Ghirardello, Anna; Milanesi, Ornella; Ruffatti, Amelia

    2017-05-01

    Congenital heart block (CHB) is an autoantibody mediated disorder presumably caused by placental transmission of maternal autoantibodies to Ro/SSA 52 kd, p200, Ro/SSA 60 kd, La/SSB ribonucleoproteins. This study investigated the clinical significance of isolated anti-Ro/SSA 52 kd, anti-p200, anti-Ro/SSA 60 kd, and anti-La/SSB antibodies in positive pregnant patients. One hundred sixty-three pregnant women positive to anti-Ro/SSA 52 kd and/or anti-Ro/SSA 60 kd and/or anti-La/SSB antibodies were prospectively enrolled in the study. Anti-Ro52, anti-Ro60, anti-p200, and anti-La antibodies were assayed using home-made ELISA assays. Isolated antibody positivity was found in 25 women (15.3%), while multiple antibody positivity in 138 (84.7%). Twenty-four developed CHB, and the 139 had a favorable pregnancy outcome. The prevalence of isolated anti-Ro/SSA 60 kd antibodies was significantly higher (p < 0.046) as the prevalence of lower mean antibody titers (p < 0.0001) in the later group. Confirmation of these results by large-scale studies could lead clinicians to recommend less stringent fetal echocardiography monitoring in women with isolated anti-Ro/SSA 60 kd antibodies.

  20. 2 CFR 2336.137 - Who in the SSA may grant an exception to let an excluded person participate in a covered...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Who in the SSA may grant an exception to let an excluded person participate in a covered transaction? 2336.137 Section 2336.137 Grants and... DEBARMENT AND SUSPENSION General § 2336.137 Who in the SSA may grant an exception to let an excluded person...

  1. 2 CFR 2336.137 - Who in the SSA may grant an exception to let an excluded person participate in a covered...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Who in the SSA may grant an exception to let an excluded person participate in a covered transaction? 2336.137 Section 2336.137 Grants and... DEBARMENT AND SUSPENSION General § 2336.137 Who in the SSA may grant an exception to let an excluded person...

  2. 2 CFR 2336.137 - Who in the SSA may grant an exception to let an excluded person participate in a covered...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Who in the SSA may grant an exception to let an excluded person participate in a covered transaction? 2336.137 Section 2336.137 Grants and... DEBARMENT AND SUSPENSION General § 2336.137 Who in the SSA may grant an exception to let an excluded person...

  3. 20 CFR 411.226 - How will SSA determine if I am meeting the timely progress guidelines if I assign my ticket prior...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false How will SSA determine if I am meeting the timely progress guidelines if I assign my ticket prior to July 21, 2008? 411.226 Section 411.226... § 411.226 How will SSA determine if I am meeting the timely progress guidelines if I assign my ticket...

  4. 2 CFR 2336.137 - Who in the SSA may grant an exception to let an excluded person participate in a covered...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Who in the SSA may grant an exception to let an excluded person participate in a covered transaction? 2336.137 Section 2336.137 Grants and... DEBARMENT AND SUSPENSION General § 2336.137 Who in the SSA may grant an exception to let an excluded person...

  5. 20 CFR 411.226 - How will SSA determine if I am meeting the timely progress guidelines if I assign my ticket prior...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false How will SSA determine if I am meeting the timely progress guidelines if I assign my ticket prior to July 21, 2008? 411.226 Section 411.226... § 411.226 How will SSA determine if I am meeting the timely progress guidelines if I assign my ticket...

  6. BOREAS RSS-4 1994 Jack Pine Leaf Biochemistry and Modeled Spectra in the SSA

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Plummer, Stephen; Lucas, Neil; Dawson, Terry

    2000-01-01

    The BOREAS RSS-4 team focused its efforts on deriving estimates of LAI and leaf chlorophyll and nitrogen concentrations from remotely sensed data for input into the Forest BGC model. This data set contains measurements of jack pine (Pinus banksiana) needle biochemistry from the BOREAS SSA in July and August 1994. The data contain measurements of current and year-1 needle chlorophyll, nitrogen, lignin, cellulose, and water content for the OJP flux tower and nearby auxiliary sites. The data have been used to test a needle reflectance and transmittance model, LIBERTY (Dawson et al., in press). The source code for the model and modeled needle spectra for each of the sampled tower and auxiliary sites are provided as part of this data set. The LIBERTY model was developed and the predicted spectral data generated to parameterize a canopy reflectance model (North, 1996) for comparison with AVIRIS, POLDER, and PARABOLA data. The data and model source code are stored in ASCII files.

  7. BOREAS TE-18 Landsat TM Physical Classification Image of the SSA

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Knapp, David

    2000-01-01

    The BOREAS TE-18 team focused its efforts on using remotely sensed data to characterize the successional and disturbance dynamics of the boreal forest for use in carbon modeling. The objective of this classification is to provide the BOREAS investigators with a data product that characterizes the land cover of the SSA. A Landsat-5 TM image from 02-Sep-1994 was used to derive the classification. A technique was implemented that uses reflectances of various land cover types along with a geometric optical canopy model to produce spectral trajectories. These trajectories are used as training data to classify the image into the different land cover classes. These data are provided in a binary image file format. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Activity Archive Center (DAAC).

  8. BOREAS TF-4 CO2 and CH4 Soil Profile Data from the SSA

    NASA Technical Reports Server (NTRS)

    Striegl, Robert; Wickland, Kimberly; Hall, Forrest G. (Editor); Conrad, Sara (Editor)

    2000-01-01

    The BOReal Ecosystem-Atmosphere Study Tower Flux (BOREAS TF-4) team measured distributions of carbon dioxide (CO2) and methane (CH4) concentrations for the upper 5 m of soil and unsaturated zone at the mature stand, upper 6 m at the 20-year-old stand, and the upper 1 m at the 8-year-old stand and clear cut area at the BOREAS Southern Study Area (SSA) during August 1993 to March 1995. Particle size and carbon content of the unsaturated deposits, precipitation, soil temperature and moisture, carbon and oxygen isotopes of soil CO2, and soil water chemistry are also presented. The data are stored in tabular ASCII files.

  9. BOREAS TE-18 Landsat TM Maximum Likelihood Classification Image of the SSA

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Knapp, David

    2000-01-01

    The BOREAS TE-18 team focused its efforts on using remotely sensed data to characterize the successional and disturbance dynamics of the boreal forest for use in carbon modeling. The objective of this classification is to provide the BOREAS investigators with a data product that characterizes the land cover of the SSA. A Landsat-5 TM image from 02-Sep- 1994 was used to derive the classification. A technique was implemented that uses reflectances of various land cover types along with a geometric optical canopy model to produce spectral trajectories. These trajectories are used as training data to classify the image into the different land cover classes. These data are provided in a binary image file format. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Center (DAAC).

  10. BOREAS RSS-8 BIOME-BGC SSA Simulation of Annual Water and Carbon Fluxes

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Nickeson, Jaime (Editor); Kimball, John

    2000-01-01

    The BOREAS RSS-8 team performed research to evaluate the effect of seasonal weather and landcover heterogeneity on boreal forest regional water and carbon fluxes using a process-level ecosystem model, BIOME-BGC, coupled with remote sensing-derived parameter maps of key state variables. This data set contains derived maps of landcover type and crown and stem biomass as model inputs to determine annual evapotranspiration, gross primary production, autotrophic respiration, and net primary productivity within the BOREAS SSA-MSA, at a 30-m spatial resolution. Model runs were conducted over a 3-year period from 1994-1996; images are provided for each of those years. The data are stored in binary image format. The data files are available on a CD-ROM (see document number 20010000884), or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  11. BOREAS TF-11 CO2 and CH4 Concentration Data from the SSA-Fen

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Conrad, Sara (Editor); Valentine, David W.

    2000-01-01

    The BOREAS TF-11 team collected several data sets in its efforts to fully describe the flux and site characteristics at the SSA-Fen site. This data set contains temperature, pH, and concentration profiles of methane and carbon dioxide within the surface 50 cm of peat. The measurements were conducted as part of a 2 x 2 factorial experiment in which we added carbon (300 g/sq m as wheat straw) and nitro-gen (6 g/sq m as urea) to four replicate locations in the vicinity of the TF-11 tower. The data set covers the period from the first week of June 1994 through the second week of September 1994. The data are stored in tabular ASCII files.

  12. The ESA SSA NEO Coordination Centre contribution to NEO hazard monitoring and observational campaigns

    NASA Astrophysics Data System (ADS)

    Micheli, Marco; Borgia, Barbara; Drolshagen, Gerhard; Koschny, Detlef; Perozzi, Ettore

    2015-08-01

    The NEO Coordination Centre (NEOCC) has recently been established in Frascati, near Rome, within the framework of the ESA Space Situational Awareness (SSA) Programme. Among its tasks is the coordination of observational activities related to the NEO hazard, and the distribution of relevant and up-to-date information on NEOs to both the scientific community and general users through its web portal (http://neo.ssa.esa.int).On the observational side, the NEOCC is linked to an increasingly large worldwide network of collaborating observatories, ranging from amateurs observers to large professional telescopes. The Centre organizes observation campaigns, alerting the network to suggest urgent or high-priority observations, and providing them with observational support.The NEOCC is also directly obtaining astrometric observations of high-priority targets, especially Virtual Impactors (VIs), on challenging objects as faint as magnitude 26.5, thanks to successful collaborations with ESO VLT in Chile and the INAF-sponsored LBT in Arizona. In addition, the Centre carries out regular monthly runs dedicated to NEO follow-up, recovery and survey activities with the 1-meter ESA OGS telescope in Tenerife.From a service perspective, the NEO System hosted at the NEOCC collects data and information on NEOs produced by various European services (e.g. NEODyS, EARN) and makes them available to a variety of users, with a particular focus on objects with possible collision solutions with the Earth. Among the tools provided through the web portal are the Risk List (a table of all known NEOs with impact solutions), a table of recent and upcoming close approaches, a database of physical properties of NEOs and the so-called Priority List, which allows observers to identify NEOs in most urgent need of observations, and prioritise their observational activities accordingly.The results of our recent observation campaigns and some major recent improvements to the NEO System will presented and

  13. 76 FR 12397 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Bureau of the Public Debt (BPD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-07

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY...))--Match Number 1038 AGENCY: Social Security Administration (SSA). ACTION: Notice of a renewal of an... matching activity is contained in sections 1631(e)(1)(B), and 1631(f) of the Social Security Act (Act), (42...

  14. 20 CFR 411.321 - Under what conditions will SSA terminate an agreement with an EN due to inadequate performance?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Under what conditions will SSA terminate an agreement with an EN due to inadequate performance? 411.321 Section 411.321 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Networks § 411.321...

  15. 20 CFR 411.321 - Under what conditions will SSA terminate an agreement with an EN due to inadequate performance?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Under what conditions will SSA terminate an agreement with an EN due to inadequate performance? 411.321 Section 411.321 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Networks § 411.321 Under...

  16. [Evaluation of an immunoblotting technique for the detection of anti-SSA and anti-SSB antibodies].

    PubMed

    Yalaoui, S; Gorgi, Y; Ayed, K

    2001-04-01

    Immunoblotting and ELISA methods are now employed for the detection of anti Ro/SSA and anti La/SSB antibodies sometimes more often than double immunodiffusion or counter-immunoelectrophoresis. We have developed an immunoblotting technique for the detection of anti Ro/SSA and anti-La/SSB antibodies. This assay named IB-Hela, which uses a Hela cell extract, was compared with the double immunodiffusion technique like two other commercial immunoassays (Elisa test from Sanofi-diagnostic Pasteur and Line immunoassay from Innogenetics). This evaluation shows a good agreement especially in the case of Ro/SSA antibodies detection. IB-Hela seems to be useful in the La/SSB detection with a better sensitivity than the double immunodiffusion technique. We conclude that the IB Hela is helpful for the search for anti-Ro/SSA and anti-La/SSB autoantibodies and that it can be used as an alternative method to the classical techniques of immunodiffusion and counter immunoelectrophoresis.

  17. 75 FR 51154 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Department of the Treasury...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Department of the Treasury... of the Privacy Act, as amended, this notice announces a renewal of an existing computer matching... INFORMATION: A. General The Computer Matching and Privacy Protection Act of 1988 (Pub. L. 100-503),...

  18. 75 FR 7648 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Department of Veterans Affairs...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Department of Veterans Affairs... INFORMATION: A. General The Computer Matching and Privacy Protection Act of 1988 (Public Law (Pub. L.) 100-503), amended the Privacy Act (5 U.S.C. 552a) by describing the conditions under which computer...

  19. 75 FR 62623 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Internal Revenue Service (IRS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... certain Federally-assisted benefit programs under the Act and the Food Stamp Act of 1977. Section 1631(e... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Internal Revenue Service (IRS... with the provisions of the Privacy Act, as amended, this notice announces a renewal of an existing...

  20. 20 CFR 404.410 - How does SSA reduce my benefits when my entitlement begins before full retirement age?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... retirement age? Generally your old-age, wife's, husband's, widow's, or widower's benefits are reduced if... benefits as a wife or husband are not reduced for any month in which you have in your care a child of the... SSA reduce my wife's or husband's benefits? Your wife's or husband's benefits before any reduction...

  1. 42 CFR 401.132 - Materials in field offices of the Office of Hearings and Appeals, SSA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Materials in field offices of the Office of Hearings and Appeals, SSA. 401.132 Section 401.132 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... (including the public information regulation of the Department of Health and Human Services). (2)...

  2. 42 CFR 401.132 - Materials in field offices of the Office of Hearings and Appeals, SSA.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Materials in field offices of the Office of Hearings and Appeals, SSA. 401.132 Section 401.132 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES... (including the public information regulation of the Department of Health and Human Services). (2)...

  3. 75 FR 32833 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Office of Personnel Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-09

    ... local government records. It requires Federal agencies involved in computer matching programs to: (1... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Office of Personnel Management... existing computer matching program that is scheduled to expire on May 28, 2010. SUMMARY: In accordance with...

  4. 75 FR 18251 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Internal Revenue Service (IRS...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-09

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Internal Revenue Service (IRS... computer matching program that is scheduled to expire on March 31, 2010. SUMMARY: In accordance with the provisions of the Privacy Act, as amended, this notice announces a renewal of an existing computer matching...

  5. 77 FR 24756 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Department of Labor (DOL))-Match...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ..., you will find an announcement of a new computer matching program (Match 1015). DATES: We will file a... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Department of Labor (DOL))--Match... computer matching program due to expire on May 31, 2012. SUMMARY: In accordance with the provisions of the...

  6. 75 FR 68396 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Department of Labor (DOL))-Match...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-05

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Department of Labor (DOL))--Match... of the Privacy Act, as amended, this notice announces a renewal of an existing computer matching... INFORMATION: A. General The Computer Matching and Privacy Protection Act of 1988 (Pub. L. 100-503),...

  7. 75 FR 59780 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Railroad Retirement Board (RRB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-28

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Railroad Retirement Board (RRB... as shown above. SUPPLEMENTARY INFORMATION: A. General The Computer Matching and Privacy Protection... persons. The Privacy Act, as amended, regulates the use of computer matching by Federal agencies...

  8. 77 FR 32709 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Department of Homeland Security...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Department of Homeland Security... the provisions of the Privacy Act, as amended, this notice announces a renewal of an existing computer.... SUPPLEMENTARY INFORMATION: A. General The Computer Matching and Privacy Protection Act of 1988 (Public Law...

  9. 78 FR 37647 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Railroad Retirement Board (RRB...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Railroad Retirement Board (RRB... of the Privacy Act, as amended, this notice announces a renewal of an existing computer matching..., as shown above. SUPPLEMENTARY INFORMATION: A. General The Computer Matching and Privacy...

  10. 78 FR 16564 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Office of Personnel Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-15

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Office of Personnel Management... Privacy Act We have taken action to ensure that all of our computer matching programs comply with the... the Computer Matching and Privacy Protection Act of 1998, and the regulations and guidance...

  11. 77 FR 33547 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Centers for Medicare and Medicaid...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-06

    ... ADMINISTRATION Privacy Act of 1974, as Amended; Computer Matching Program (SSA/ Centers for Medicare and Medicaid... of the Privacy Act, as amended, this notice announces a new computer matching program that we will... Privacy Act We have taken action to ensure that all of our computer matching programs comply with...

  12. Fetal echocardiographic assessment of endocardial fibroelastosis in maternal anti-SSA antibody-associated complete heart block.

    PubMed

    Aoki, Hisaaki; Inamura, Noboru; Kawazu, Yukiko; Nakayama, Masahiro; Kayatani, Futoshi

    2011-01-01

    There are few reports describing the features of maternal anti-SSA antibody-associated congenital complete heart block (CCHB) patients developing endocardial fibroelastosis (EFE). The aim of this study was to describe the clinical features and the outcome of patients with CCHB, with or without EFE. Over a 20-year period, 12 consecutive patients diagnosed with maternal anti-SSA antibody-associated CCHB were identified. The maternal anti-SSA antibody levels were measured and fetal echocardiographic findings were reviewed. The ratios of the thickness of the endocardium to that of the whole wall of the left ventricle (LE/W) and right ventricle (RE/W) were measured to investigate the degree of endocardial thickening. A total of 7 patients survived (living group) and were not diagnosed as having EFE. The remaining 5 patients died and were diagnosed with EFE during autopsy (dead group). Fetal echocardiography of the patients showed differences in the thickening and hyperintensity of the endocardium. The RE/W value was significantly higher in the dead group than in the living group. The titers of both maternal anti-52-kDa and anti-60-kDa SSA antibodies were high, but showed no significant differences between the 2 patient groups. EFE was the major negative prognostic factor for CCHB. Myocardial damage, predominantly in the right ventricle, was related to the outcome of CCHB associated with EFE.

  13. Combination use of anti-CD133 antibody and SSA lectin can effectively enrich cells with high tumorigenicity.

    PubMed

    Moriwaki, Kenta; Okudo, Kumiko; Haraguchi, Naotsugu; Takeishi, Shunsaku; Sawaki, Hiromichi; Narimatsu, Hisashi; Tanemura, Masahiro; Ishii, Hideshi; Mori, Masaki; Miyoshi, Eiji

    2011-06-01

    Glycans exhibit characteristic changes in their structures during development and thus have been used as markers for stem/progenitor cells. However, the glycan structures unique to cancer stem cells (CSC) remain unknown. In the present study, we examined glycan structures in CD133+ CD13+ CSC, which were recently found to have a high CSC ability, by means of a lectin microarray. Seven sialylated glycan-recognizing lectins, MAL-I, SNA, SSA, TJA-I, ACG, ABA and MAH, showed higher affinity to CD133+ CD13+ CSC than CD133+ cells with a lower CSC ability. In addition, we demonstrated that CD133+ SSA+ cells isolated from Huh7 cells had a significantly higher ability to form tumors in non-obese diabetic/severe combined immunodeficiency disease (NOD/SCID) mice and spheres under serum-free conditions than CD133+ SSA- cells. These results suggest that hepatic CSC highly express sialylated glycans and that SSA lectin can be used as a tool for isolating CSC. This study is the first report to demonstrate the characteristic glycan structures in CSC and to indicate a new methodology involving lectins for isolating CSC. © 2011 Japanese Cancer Association.

  14. VizieR Online Data Catalog: AzTEC/ASTE 1.1mm survey of SSA22 (Umehata+, 2014)

    NASA Astrophysics Data System (ADS)

    Umehata, H.; Tamura, Y.; Kohno, K.; Hatsukade, B.; Scott, K. S.; Kubo, M.; Yamada, T.; Ivison, R. J.; Cybulski, R.; Aretxaga, I.; Austermann, J.; Hughes, D. H.; Ezawa, H.; Hayashino, T.; Ikarashi, S.; Iono, D.; Kawabe, R.; Matsuda, Y.; Matsuo, H.; Nakanishi, K.; Oshima, T.; Perera, T.; Takata, T.; Wilson, G. W.; Yun, M. S.

    2015-01-01

    We used the AzTEC camera operating at 1.1mm mounted on the ASTE 10-m submillimetre telescope located at Pampa la Bola, near Cerro Chajnantor in northern Chile. All of the AzTEC/ASTE observations of SSA22 were carried out at night during 2007 August-September and 2008 August-September. (4 data files).

  15. 20 CFR 411.321 - Under what conditions will SSA terminate an agreement with an EN due to inadequate performance?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 2 2014-04-01 2014-04-01 false Under what conditions will SSA terminate an agreement with an EN due to inadequate performance? 411.321 Section 411.321 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Networks § 411.321 Under...

  16. 20 CFR 411.321 - Under what conditions will SSA terminate an agreement with an EN due to inadequate performance?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 2 2012-04-01 2012-04-01 false Under what conditions will SSA terminate an agreement with an EN due to inadequate performance? 411.321 Section 411.321 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Networks § 411.321 Under...

  17. 77 FR 49849 - Privacy Act of 1974, as Amended; Computer Matching Program (SSA/Office of Child Support...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-17

    ... beneficiaries during periodic screening; and (3) in administering the Extra Help program. C. Authority for... to SSA. We will provide OCSE the following data elements electronically in the finder file: Client's... elements electronically from the NDNH: a. Quarterly Wage File: QW record identifier, For employees: (1...

  18. 20 CFR 411.321 - Under what conditions will SSA terminate an agreement with an EN due to inadequate performance?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Under what conditions will SSA terminate an agreement with an EN due to inadequate performance? 411.321 Section 411.321 Employees' Benefits SOCIAL SECURITY ADMINISTRATION THE TICKET TO WORK AND SELF-SUFFICIENCY PROGRAM Employment Networks § 411.321...

  19. 20 CFR 416.582 - Review within SSA that an overpayment is past due and legally enforceable.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 2 2013-04-01 2013-04-01 false Review within SSA that an overpayment is past due and legally enforceable. 416.582 Section 416.582 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Payment of Benefits, Overpayments...

  20. Atomic polarizabilities

    SciTech Connect

    Safronova, M. S.; Mitroy, J.; Clark, Charles W.; Kozlov, M. G.

    2015-01-22

    The atomic dipole polarizability governs the first-order response of an atom to an applied electric field. Atomic polarization phenomena impinge upon a number of areas and processes in physics and have been the subject of considerable interest and heightened importance in recent years. In this paper, we will summarize some of the recent applications of atomic polarizability studies. A summary of results for polarizabilities of noble gases, monovalent, and divalent atoms is given. The development of the CI+all-order method that combines configuration interaction and linearized coupled-cluster approaches is discussed.

  1. Presence of anti-Ro/SSA antibody may be associated with anti-aquaporin-4 antibody positivity in neuromyelitis optica spectrum disorder.

    PubMed

    Park, Jae-Hyun; Hwang, Jaechun; Min, Ju-Hong; Kim, Byoung Joon; Kang, Eun-Suk; Lee, Kwang Ho

    2015-01-15

    Neuromyelitis optica (NMO) is often associated with systemic autoimmune diseases or serological markers of non-organ-specific autoimmunity, and has been most frequently associated with Sjögren's syndrome and anti-Ro/SSA antibody (SSA-Ab) positivity in Asian populations. We evaluated the clinical significance of anti-Ro/SSA antibody positivity in patients with NMO spectrum disorder (NMOSD). We retrospectively collected data from 106 consecutive patients with NMOSD and reviewed clinical features and laboratory findings. All patients underwent tests for SSA-Ab and anti-aquaporin-4 antibody (AQP4-Ab) using cell-based indirect immunofluorescence assays. Among 106 patients, 20 (18.9%) were positive for SSA-Ab. Of 48 AQP4-Ab-positive patients, 18 (37.5%) had SSA-Ab. AQP4-Ab seropositivity was 90.0% in patients positive for SSA-Ab, and 32.6% in patients without SSA-Ab (p<0.001). Presence of SSA-Ab was associated with systemic autoimmune diseases, including Sjögren's syndrome (p<0.001) and systemic lupus erythematosus (p=0.003), and with the presence of non-organ-specific autoantibodies such as anti-nuclear antibody and anti-dsDNA antibody in patients with NMOSD, but was not associated with annualized relapse rate or final Expanded Disability Status Scale score independent of AQP4-Ab positivity. We found that the presence of SSA-Ab was highly associated with seropositivity for AQP4-Ab in patients with NMOSD. Copyright © 2014 Elsevier B.V. All rights reserved.

  2. Differential expression of Ro/SSA 60 kDa and La/SSB, but not Ro/SSA 52 kDa, mRNA and protein in minor salivary glands from patients with primary Sjögren's syndrome.

    PubMed

    Barcellos, Karin S A; Nonogaki, Suely; Enokihara, Milvia M S S; Teixeira, Miriam S; Andrade, Luís E C

    2007-06-01

    To analyze the protein and messenger RNA (mRNA) expression of La/SSB, Ro/SSA 60, and Ro/SSA 52 antigens in minor salivary glands (MSG) from patients with primary Sjögren's syndrome (pSS). La/SSB, Ro/SSA 60, and Ro/SSA 52 protein expression was studied by immunohistochemistry in MSG from 26 patients with pSS and 16 controls. mRNA expression was determined by real-time polymerase chain reaction in MSG of 10 patients with pSS and 7 controls. La/SSB and Ro/SSA 60, but not Ro/SSA 52, mRNA expression was higher in samples from patients with pSS compared to controls (p < 0.05). La/SSB protein had higher expression in the cytoplasm of ductal cells than in the cytoplasm of mucous acinar cells in patients with pSS (p = 0.013) but not in controls. Ro/SSA 60 had higher expression in the cytoplasm of ductal cells than in the cytoplasm of serous acinar cells in patients with pSS (p = 0.006) but not in controls. The Ro/SSA 52 expression pattern was similar in patients and controls. There was no association between circulating autoantibodies to Ro/SSA or La/SSB and the aberrant expression of the cognate autoantigens. The increased Ro/SSA 60 and La/SSB mRNA expression in MSG of patients with pSS as well as the differential Ro/SSA 60 and La/SSB protein expression in ductal cells of MSG in patients with pSS suggest that these these 2 autoantigens, but not Ro/SSA 52, are probably involved in triggering and maintaining the tissue-specific autoimmune response in pSS MSG and may contribute to the antigen-driven immune response and local autoantibody production in pSS.

  3. Neonatal lupus: Follow-up in infants with anti-SSA/Ro antibodies and review of the literature.

    PubMed

    Zuppa, Antonio Alberto; Riccardi, Riccardo; Frezza, Simonetta; Gallini, Francesca; Luciano, Rita Maria Paola; Alighieri, Giovanni; Romagnoli, Costantino; De Carolis, Sara

    2017-04-01

    Neonatal Lupus Syndrome (NLS) is a distinct clinical entity caused by transplacental passage of maternal anti-SSA/Ro antibodies (Ab). Mothers may have systemic lupus erythematosus, Sjögren syndrome, or other connective tissue disease, or may be completely healthy at the time of giving birth. NLS includes several clinical manifestations: complete congenital heart block (CCHB) and cutaneous lupus are the most common, while hepatobiliary disease, hematological manifestations and central nervous system involvement may occur. Data from literature on the incidence of the different clinical manifestations of NLS are difficult to compare because they come mostly from retrospective studies or prospective studies, but up to date no systematic follow-up was carried out. We performed a large prospective single-center study with a systematic clinical and instrumental follow-up until 9months of life, in order to evaluate the incidence and the clinical impact of NLS features. From 2004 to 2014 all infants born in our center to mothers with anti-SSA/Ro Ab were enrolled in a specific diagnostic and follow-up (FU) program. At birth, 50 infants born to mothers with anti-SSA/Ro Ab were found positive for anti-SSA/Ro Ab. Infants were tested for anti SSA/Ro Ab at 3months of life, if positive they were re-tested at 6 and 9months. At 9months anti-SSA/Ro Ab were positive in 10% of children. In two cases (4%) a CCHB was identified during pregnancy and required pacemaker implantation at birth. In 10% of cases a transient ECG alterations was found during follow-up. Hematological NLS features (anemia, neutropenia, thrombocytopenia) were found at birth and during FU in several patients, in all cases without clinical manifestations and in most cases with complete normalization at 9months. Mild and transient elevation of aminotransferases between 3 and 6months of life were found in 56% and 40% of patient, respectively; non-specific ultrasound cerebral anomalies in absence of clinical

  4. Sewage sludge ash (SSA) from large and small incineration plants as a potential source of phosphorus - Polish case study.

    PubMed

    Smol, Marzena; Kulczycka, Joanna; Kowalski, Zygmunt

    2016-12-15

    The aim of this research is to present the possibility of using the sewage sludge ash (SSA) generated in incineration plants as a secondary source of phosphorus (P). The importance of issues related to P recovery from waste materials results from European Union (UE) legislation, which indicated phosphorus as a critical raw material (CRM). Due to the risks of a shortage of supply and its impact on the economy, which is greater than other raw materials, the proper management of phosphorus resources is required in order to achieve global P security. Based on available databases and literature, an analysis of the potential use of SSA for P-recovery in Poland was conducted. Currently, approx. 43,000 Mg/year of SSA is produced in large and small incineration plants and according to in the Polish National Waste Management Plan 2014 (NWMP) further steady growth is predicted. This indicates a great potential to recycle phosphorus from SSA and to reintroduce it again into the value chain as a component of fertilisers which can be applied directly on fields. The amount of SSA generated in installations, both large and small, varies and this contributes to the fact that new and different P recovery technology solutions must be developed and put into use in the years to come (e.g. mobile/stationary P recovery installations). The creation of a database focused on the collection and sharing of data about the amount of P recovered in EU and Polish installations is identified as a helpful tool in the development of an efficient P management model for Poland.

  5. Pro-inflammatory role of Anti-Ro/SSA autoantibodies through the activation of Furin-TACE-amphiregulin axis.

    PubMed

    Lisi, Sabrina; Sisto, Margherita; Lofrumento, Dario Domenico; Cucci, Liana; Frassanito, Maria Antonia; Mitolo, Vincenzo; D'Amore, Massimo

    2010-09-01

    Prolonged inflammation can be detrimental because it may cause host toxicity and tissue damage. Indeed, excessive production of inflammatory cytokines is often associated with many autoimmune diseases. In this study we demonstrate that the anti-Ro/SSA autoantibodies (Abs) stimulate the production of pro-inflammatory cytokines IL-6 and IL-8 by human healthy salivary gland epithelial cells (healthy SGEC). The secretion of these cytokines is due to amphiregulin (AREG) that is overexpressed in healthy SGEC treated with anti-Ro/SSA Abs and in Sjögren's syndrome. We have discovered that the up-regulation of AREG occurs through TNF-alpha produced following anti-Ro/SSA Abs treatment. The gene silencing technique was used to study the AREG-TNF-alpha-IL-6/IL-8 secretion pathway, demonstrating that: (i) TNF-alpha gene silencing provokes a significant decrease of proinflammatory cytokines production and AREG expression in anti-Ro/SSA Abs-treated healthy SGEC; (ii) AREG gene silencing has a potent inhibitory effect on TNF-alpha-induced IL-6 and IL-8 secretion in healthy SGEC treated with anti-Ro/SSA Abs. These findings indicate that TACE-mediated AREG shedding plays a critical role in TNF-alpha-induced IL-6 and IL-8 secretion by the human healthy salivary gland epithelial cells, suggesting that this may be one of the possible intracellular mechanisms involved in the salivary glands inflammatory response in Sjögren's syndrome. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

  6. Hsp70 chaperones as modulators of prion life cycle: novel effects of Ssa and Ssb on the Saccharomyces cerevisiae prion [PSI+].

    PubMed

    Allen, Kim D; Wegrzyn, Renee D; Chernova, Tatiana A; Müller, Susanne; Newnam, Gary P; Winslett, Peggy A; Wittich, Kristin B; Wilkinson, Keith D; Chernoff, Yury O

    2005-03-01

    [PSI(+)] is a prion isoform of the yeast release factor Sup35. In some assays, the cytosolic chaperones Ssa1 and Ssb1/2 of the Hsp70 family were previously shown to exhibit "pro-[PSI(+)]" and "anti-[PSI(+)]" effects, respectively. Here, it is demonstrated for the first time that excess Ssa1 increases de novo formation of [PSI(+)] and that pro-[PSI(+)] effects of Ssa1 are shared by all other Ssa proteins. Experiments with chimeric constructs show that the peptide-binding domain is a major determinant of differences in the effects of Ssa and Ssb proteins on [PSI(+)]. Surprisingly, overproduction of either chaperone increases loss of [PSI(+)] when Sup35 is simultaneously overproduced. Excess Ssa increases both the average size of prion polymers and the proportion of monomeric Sup35 protein. Both in vivo and in vitro experiments uncover direct physical interactions between Sup35 and Hsp70 proteins. The proposed model postulates that Ssa stimulates prion formation and polymer growth by stabilizing misfolded proteins, which serve as substrates for prion conversion. In the case of very large prion aggregates, further increase in size may lead to the loss of prion activity. In contrast, Ssb either stimulates refolding into nonprion conformation or targets misfolded proteins for degradation, in this way counteracting prion formation and propagation.

  7. Specific testing for "isolated" anti-52 kDa SSA/Ro antibodies during standard anti-extractable nuclear antigen testing is of limited clinical value.

    PubMed

    Langguth, Daman M; Morris, Samantha; Clifford, Lynette; Wilson, Robert J; Neil, John; Hogan, Patrick G; Wong, Richard C W

    2007-06-01

    To ascertain whether specific testing for "isolated" anti-52 kDa SSA/Ro antibodies (a-SSA/Ro52) during standard anti-extractable nuclear antigen (ENA) testing is clinically useful. 1438 consecutive sera submitted for anti-ENA testing over 1 year were evaluated for a-SSA/Ro52 using various assays. 7 of 1438 (0.48%) patients were found to have a-SSA/Ro52 without SSA/Ro60 antibodies. Subsequent testing detected a further five patients. Clinical follow-up was possible in 10/12 patients. 2 of these 10 patients had evidence of primary Sjögren's syndrome (SS) and one had systemic lupus erythematosus (SLE), with sicca symptoms and abnormal Schirmer's tests. Five other patients had sicca symptoms, of which four had abnormal Schirmer's tests. "Isolated" anti-52 kDa SSA/Ro antibodies were detected in approximately 0.5% of standard anti-ENA requests, in which their presence was generally not associated with underlying SS or SLE. In view of the increased testing complexity and costs in detecting and confirming these antibodies, specific testing for isolated a-SSA Ro52 antibodies during standard anti-ENA testing seems to be of limited clinical value in a non-obstetric population.

  8. Association of various inflammatory diseases with human leukocyte antigens B27, B7, Bw4 and Bw6 in patients with SSA.

    PubMed

    Singh, Sangeeta; Sonkar, Gyanendra K; Singh, Usha

    2009-07-01

    Seronegative spondyloarthropathies (SSA) are a group of inflammatory disorders, which clinically involve the axial skeleton and the sacroiliiac and shoulder joints. The aim of the present study was to study the association of HLA B27, B7, Bw4 and Bw6 with some inflammatory diseases, in SSA patients in our area. A total of 220 SSA patients were studied and HLA typing for these antigens were done by the complement-mediated microcytotoxicity method. The total positivity of B27 was found to be 68.64% in SSA patients. Tubercular infection (chi(2) = 8.06) and acute anterior uveitis (chi(2) = 6.19) were found to be statistically significant (P < 0.05) in B27-positive SSA patients. Tuberculosis was also found to be significantly (chi(2) = 6.40) associated with Bw4. In SSA urinary tract infection, gastrointestinal infection and streptococcal infection were not significantly associated with B27, B7, Bw4 or Bw6 antigens. Our study concludes that microbial infections do have some pathogenic role in causing SSA.

  9. SUBMILLIMETER ARRAY IDENTIFICATION OF THE MILLIMETER-SELECTED GALAXY SSA22-AzTEC1: A PROTOQUASAR IN A PROTOCLUSTER?

    SciTech Connect

    Tamura, Y.; Iono, D.; Hatsukade, B.; Kawabe, R.; Wilner, D. J.; Chung, A.; Kajisawa, M.; Hayashino, T.; Ichikawa, T.; Uchimoto, Y. K.; Ikarashi, S.; Kohno, K.; Alexander, D. M.; Lehmer, B. D.; Matsuda, Y.; Ezawa, H.; Nakanishi, K.; Takata, T.; Hughes, D. H.; Wilson, G. W.

    2010-12-01

    We present results from Submillimeter Array (SMA) 860 {mu}m subarcsecond astrometry and multiwavelength observations of the brightest millimeter (S{sub 1.1mm} = 8.4 mJy) source, SSA22-AzTEC1, found near the core of the SSA22 protocluster that is traced by Ly{alpha}-emitting galaxies at z = 3.09. We identify a 860 {mu}m counterpart with a flux density of S{sub 860{sub {mu}m}} = 12.2 {+-} 2.3 mJy and absolute positional accuracy that is better than 0.''3. At the SMA position, we find radio-to-mid-infrared counterparts, whilst no object is found in Subaru optical and near-infrared deep images at wavelengths {<=}1 {mu}m (J > 25.4 in AB, 2{sigma}). The photometric redshift estimate, using flux densities at {>=}24 {mu}m, indicates z{sub phot} = 3.19{sup +0.26}{sub -0.35}, consistent with the protocluster redshift. We then model the near-to-mid-infrared spectral energy distribution (SED) of SSA22-AzTEC1, and find that the SED modeling requires a large extinction (A{sub V} {approx} 3.4 mag) of starlight from a stellar component with M{sub star} {approx} 10{sup 10.9} M{sub sun}, assuming z = 3.1. Additionally, we find a significant X-ray counterpart with a very hard spectrum ({Gamma}{sub eff} = -0.34{sup +0.57}{sub -0.61}), strongly suggesting that SSA22-AzTEC1 harbors a luminous active galactic nuclei (AGNs; L{sub X} {approx} 3 x 10{sup 44} erg s{sup -1}) behind a large hydrogen column (N{sub H} {approx} 10{sup 24} cm{sup -2}). The AGN, however, is responsible for only {approx}10% of the bolometric luminosity of the host galaxy, and therefore the star formation activity likely dominates the submillimeter emission. It is possible that SSA22-AzTEC1 is the first example of a protoquasar growing at the bottom of the gravitational potential underlying the SSA22 protocluster.

  10. Observer Interface Analysis for Standardization to a Cloud Based Real-Time Space Situational Awareness (SSA)

    NASA Astrophysics Data System (ADS)

    Eilers, J.

    2013-09-01

    The interface analysis from an observer of space objects makes a standard necessary. This standardized dataset serves as input for a cloud based service, which aimed for a near real-time Space Situational Awareness (SSA) system. The system contains all advantages of a cloud based solution, like redundancy, scalability and an easy way to distribute information. For the standard based on the interface analysis of the observer, the information can be separated in three parts. One part is the information about the observer e.g. a ground station. The next part is the information about the sensors that are used by the observer. And the last part is the data from the detected object. Backbone of the SSA System is the cloud based service which includes the consistency check for the observed objects, a database for the objects, the algorithms and analysis as well as the visualization of the results. This paper also provides an approximation of the needed computational power, data storage and a financial approach to deliver this service to a broad community. In this context cloud means, neither the user nor the observer has to think about the infrastructure of the calculation environment. The decision if the IT-infrastructure will be built by a conglomerate of different nations or rented on the marked should be based on an efficiency analysis. Also combinations are possible like starting on a rented cloud and then go to a private cloud owned by the government. One of the advantages of a cloud solution is the scalability. There are about 3000 satellites in space, 900 of them are active, and in total there are about ~17.000 detected space objects orbiting earth. But for the computation it is not a N(active) to N problem it is more N(active) to N(apo peri) quantity of N(all). Instead of 15.3 million possible collisions to calculate a computation of only approx. 2.3 million possible collisions must be done. In general, this Space Situational Awareness System can be used as a

  11. The influence of quorum sensing in compartment II of the MELiSSA loop

    NASA Astrophysics Data System (ADS)

    Condori, Sandra; Mastroleo, Felice; Wattiez, Ruddy; Leys, Natalie

    MELiSSA (Micro-Ecological Life Support System Alternative) has been conceived as a 5 compartments microorganisms and higher plants recycling system for long haul space flights. Rhodospirillum rubrum S1H colonizes compartment II. Previous work reported that continuous culture of the bacterium in a photobioreactor could lead to thick biofilm formation, leading to bioreactor arrest. Our aim is to investigate the unknown quorum sensing (QS) system of R. rubrum S1H, specifically under MELiSSA relevant culture conditions meaning light anaerobic (LAN) and using acetate as carbon source. In that purpose an autoinducer synthase gene (Rru_A3396) knockout mutant was constructed by allelic exchange generating strain M68. In addition phenotypic comparison between wild type (WT) and M68 was performed. Results of thin layer chromatography assay where Agrobacterium tumefaciens NT1 have been used as reporter strain showed that WT produces acyl-homoserine lactones (AHLs) from C4 to C12 acyl carbon chain length; however, in M68 no AHLs were detected confirming that gene Rru_A3396 (named rruI) encodes an autoinducer synthase. Interestingly under a low shear or static environment M68 showed cell aggregation similar as reported in a closely related bacterium Rhodobacter sphaeroides (cerI mutant). In contrast to WT, M68 did not form biofilm and exhibited a decreased motility and pigment content. M68 vs wild type transcriptomics results showed that 326 genes were statistically significant differentially expressed. Downregulation of genes related to photosynthesis e.g., reaction center subunits, light harvesting complex and photosynthetic assembly proteins was observed. Similar results were obtained for preliminary proteomic analysis. Results obtained showed that in R. rubrum S1H the AHL-based QS system regulates almost 8% of the genome which is linked to biofilm formation among other biological processes described above. Since strain M68 could not be used in compartment II due to its less

  12. Parameterization of single-scattering albedo (SSA) and absorption Ångström exponent (AAE) with EC / OC for aerosol emissions from biomass burning

    NASA Astrophysics Data System (ADS)

    Pokhrel, Rudra P.; Wagner, Nick L.; Langridge, Justin M.; Lack, Daniel A.; Jayarathne, Thilina; Stone, Elizabeth A.; Stockwell, Chelsea E.; Yokelson, Robert J.; Murphy, Shane M.

    2016-08-01

    Single-scattering albedo (SSA) and absorption Ångström exponent (AAE) are two critical parameters in determining the impact of absorbing aerosol on the Earth's radiative balance. Aerosol emitted by biomass burning represent a significant fraction of absorbing aerosol globally, but it remains difficult to accurately predict SSA and AAE for biomass burning aerosol. Black carbon (BC), brown carbon (BrC), and non-absorbing coatings all make substantial contributions to the absorption coefficient of biomass burning aerosol. SSA and AAE cannot be directly predicted based on fuel type because they depend strongly on burn conditions. It has been suggested that SSA can be effectively parameterized via the modified combustion efficiency (MCE) of a biomass burning event and that this would be useful because emission factors for CO and CO2, from which MCE can be calculated, are available for a large number of fuels. Here we demonstrate, with data from the FLAME-4 experiment, that for a wide variety of globally relevant biomass fuels, over a range of combustion conditions, parameterizations of SSA and AAE based on the elemental carbon (EC) to organic carbon (OC) mass ratio are quantitatively superior to parameterizations based on MCE. We show that the EC / OC ratio and the ratio of EC / (EC + OC) both have significantly better correlations with SSA than MCE. Furthermore, the relationship of EC / (EC + OC) with SSA is linear. These improved parameterizations are significant because, similar to MCE, emission factors for EC (or black carbon) and OC are available for a wide range of biomass fuels. Fitting SSA with MCE yields correlation coefficients (Pearson's r) of ˜ 0.65 at the visible wavelengths of 405, 532, and 660 nm while fitting SSA with EC / OC or EC / (EC + OC) yields a Pearson's r of 0.94-0.97 at these same wavelengths. The strong correlation coefficient at 405 nm (r = 0.97) suggests that parameterizations based on EC / OC or EC / (EC + OC) have good predictive

  13. Atomic Calligraphy

    NASA Astrophysics Data System (ADS)

    Imboden, Matthias; Pardo, Flavio; Bolle, Cristian; Han, Han; Tareen, Ammar; Chang, Jackson; Christopher, Jason; Corman, Benjamin; Bishop, David

    2013-03-01

    Here we present a MEMS based method to fabricate devices with a small number of atoms. In standard semiconductor fabrication, a large amount of material is deposited, after which etching removes what is not wanted. This technique breaks down for structures that approach the single atom limit, as it is inconceivable to etch away all but one atom. What is needed is a bottom up method with single or near single atom precision. We demonstrate a MEMS device that enables nanometer position controlled deposition of gold atoms. A digitally driven plate is swept as a flux of gold atoms passes through an aperture. Appling voltages on four comb capacitors connected to the central plate by tethers enable nanometer lateral precision in the xy plane over 15x15 sq. microns. Typical MEMS structures have manufacturing resolutions on the order of a micron. Using a FIB it is possible to mill apertures as small as 10 nm in diameter. Assuming a low incident atomic flux, as well as an integrated MEMS based shutter with microsecond response time, it becomes possible to deposit single atoms. Due to their small size and low power consumption, such nano-printers can be mounted directly in a cryogenic system at ultrahigh vacuum to deposit clean quench condensed metallic structures.

  14. Atomic supersymmetry

    NASA Technical Reports Server (NTRS)

    Kostelecky, V. Alan

    1993-01-01

    Atomic supersymmetry is a quantum-mechanical supersymmetry connecting the properties of different atoms and ions. A short description of some established results in the subject are provided and a few recent developments are discussed including the extension to parabolic coordinates and the calculation of Stark maps using supersymmetry-based models.

  15. Benefits of Applying Predictive Intelligence to the Space Situational Awareness (SSA) Mission

    NASA Astrophysics Data System (ADS)

    Lane, B.; Mann, B.; Millard, C.

    Recent events have heightened the interest in providing improved Space Situational Awareness (SSA) to the warfighter using novel techniques that are affordable and effective. The current Space Surveillance Network (SSN) detects, tracks, catalogs and identifies artificial objects orbiting earth and provides information on Resident Space Objects (RSO) as well as new foreign launch (NFL) satellites. The reactive nature of the SSN provides little to no warning on changes to the expected states of these RSOs or NFLs. This paper will detail the use of the historical data collected on RSOs to characterize what their steady state is, proactively help identify when changes or anomalies have occurred using a pattern-of-like activity based intelligence approach, and apply dynamic, adaptive mission planning to the observables that lead up to a NFL. Multiple hypotheses will be carried along with the intent or the changes to the steady state to assist the SSN in tasking the various sensors in the network to collect the relevant data needed to help prune the number of hypotheses by assigning likelihood to each of those activities. Depending on the hypothesis and thresholds set, these likelihoods will then be used in turn to alert the SSN operator with changes to the steady state, prioritize additional data collections, and provide a watch list of likely next activities.

  16. BOREAS AFM-1 NOAA/ATDD Long-EZ Aircraft Flux data Over the SSA

    NASA Technical Reports Server (NTRS)

    Crawford, Timothy L.; Baldocchi, Dennis; Hall, Forrest G. (Editor); Knapp, David E. (Editor); Gunter, Laureen; Dumas, Ed; Smith, David E. (Technical Monitor)

    2000-01-01

    This data set contains measurements from the Airborne Flux and Meteorology (AFM)-1 National Oceanographic and Atmospheric Administration/Atmospheric Turbulence and Diffusion Division (NOAA/ATDD) Long-EZ Aircraft collected during the 1994 Intensive Field Campaigns (IFCs) at the southern study area (SSA). These measurements were made from various instruments mounted on the aircraft. The data that were collected include aircraft altitude, wind direction, wind speed, air temperature, potential temperature, water mixing ratio, U and V components of wind velocity, static pressure, surface radiative temperature, downwelling and upwelling total radiation, downwelling and upwelling longwave radiation, net radiation, downwelling and upwelling photosynthectically active radiation (PAR), greenness index, CO2 concentration, O3 concentration, and CH4 concentration. There are also various columns that indicate the standard deviation, skewness, kurtosis, and trend of some of these data. The data are stored in tabular ASCII files. The NOAA/ATDD Long-EZ aircraft flux data are available from the Earth Observing System Data and Information System (EOSDIS) Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC). The data files are available on a CD-ROM (see document number 20010000884).

  17. BOREAS TGB-8 Monoterpene Concentration Data over the SSA-OBS

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Conrad, Sara K. (Editor); Lerdau, Manuel

    2000-01-01

    The BOREAS TGB-8 team collected data to investigate the controls over NMHC fluxes from boreal forest tree species. This data set contains measurements of monoterpene concentrations in collected foliar gas emissions and foliar samples. The data were collected at the OJP and OBS tower flux sites in the SSA and were the locus for the monoterpene emission measurements. These areas contained mature stands of jack pine and black spruce and were the focal sites in the BOREAS program for studies of biosphere/atmosphere exchange from these two habitat types. The OBS site is situated in a black spruce/sphagnum bog with the largest trees 155 years old and 10-15 m tall. The OJP site is in a jack pine forest, 80 to 120 years old, which lies on a sandy bench of glacial outwash with the largest tree standing 15 m tall. Temporally, the data cover the period of 24-May-1994 to 19-Sep-1994. The data are stored in tabular ASCII files.

  18. BOREAS AFM-08 ECMWF Hourly Surface and Upper Air Data for the SSA and NSA

    NASA Technical Reports Server (NTRS)

    Viterbo, Pedro; Betts, Alan; Hall, Forrest G. (Editor); Newcomer, Jeffrey A.; Smith, David E. (Technical Monitor)

    2000-01-01

    The Boreal Ecosystem-Atmosphere Study (BOREAS) Airborne Fluxes and Meteorology (AFM)-8 team focused on modeling efforts to improve the understanding of the diurnal evolution of the convective boundary layer over the boreal forest. This data set contains hourly data from the European Center for for Medium-Range Weather Forecasts (ECMWF) operational model from below the surface to the top of the atmosphere, including the model fluxes at the surface. Spatially, the data cover a pair of the points that enclose the rawinsonde sites at Candle Lake, Saskatchewan, in the Southern Study Area (SSA) and Thompson, Manitoba, in the Northern Study Area (NSA). Temporally, the data include the two time periods of 13 May 1994 to 30 Sept 1994 and 01 Mar 1996 to 31 Mar 1997. The data are stored in tabular ASCII files. The number of records in the upper air data files may exceed 20,000, causing a problem for some software packages. The ECMWF hourly surface and upper air data are available from the Earth Observing System Data and Information System (EOSDIS) Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC). The data files are available on a CD-ROM (see document number 20010000884).

  19. Viable Biomass Sensor integration in the MELiSSA CI and CIII compartments

    NASA Astrophysics Data System (ADS)

    Duatis Juarez, Jordi; Peiro, Enrique; Bragos, Ramon

    Traditionally, the biomass quantity and quality in complex substrate reactor (e.g. activated sludge, high density, fixed bed,..) is determined off-line in laboratories. Within this study, the VIAMASS Sensor System, which uses Electrical Impedance Spectroscopy (EIS) techniques, has been tested for MELiSSA compartment CI and C III, the liquefying and the nitrifying compartment respectively. This sensor is able to measure viable cells on basis of an impedance spectroscopy measurement. The fact that viable biomass can be detected, distinguishes the sensor from classical biomass sensors used in wastewater treatment plants. Detection of viable biomass and composition of the biomass can be very useful for calibration and validation of biological models. The sensor can be used to detect toxicity in system leading to die-off of organisms. The technology developed initially for space applications has been adapted and will be also able to give overall information on the population distribution of cells, distinguishing what type of biomass is dominant (for example, bacteria or protozoa).

  20. Hazard Analysis for the Mark III Space Suit Assembly (SSA) Used in One-g Operations

    NASA Technical Reports Server (NTRS)

    Mitchell, Kate; Ross, Amy; Blanco, Raul; Wood, Art

    2012-01-01

    This Hazard Analysis document encompasses the Mark III Space Suit Assembly (SSA) and associated ancillary equipment. It has been prepared using JSC17773, "Preparing Hazard Analyses for JSC Ground Operation", as a guide. The purpose of this document is to present the potential hazards involved in ground (23 % maximum O2, One-g) operations of the Mark III and associated ancillary support equipment system. The hazards listed in this document are specific to suit operations only; each supporting facility (Bldg. 9, etc.) is responsible for test specific Hazard Analyses. A "hazard" is defined as any condition that has the potential for harming personnel or equipment. This analysis was performed to document the safety aspects associated with manned use of the Mark III for pressurized and unpressurized ambient, ground-based, One-g human testing. The hazards identified herein represent generic hazards inherent to all standard JSC test venues for nominal ground test configurations. Non-standard test venues or test specific configurations may warrant consideration of additional hazards analysis prior to test. The cognizant suit engineer is responsible for the safety of the astronaut/test subject, space suit, and suit support personnel. The test requester, for the test supported by the suit test engineer and suited subject, is responsible for overall safety and any necessary Test Readiness Reviews (TRR).

  1. Submillimeter Galaxies in the SSA22 Protocluster at z = 3.1

    NASA Astrophysics Data System (ADS)

    Umehata, H.; Tamura, Y.; Kohno, K.

    2013-10-01

    We present the results from the 1.1mm continuum imaging the SSA22 field, which is known as an protocluster field which is traced by Lyα emitting galaxies (LAEs) at z = 3.1, with the AzTEC camera on ASTE telescope. We find 112 submillimeter(1.1mm)-selected galaxies (SMGs) with signal to noise ratio of ≥3.5 within 50% coverage region. Counterpart identification analysis utilizing radio(1.4GHz), MIPS ch1(24 μm) imaging data and IRAC color(3.6 μm, 4.5 μm, 5.8 μm, and 8.0 μm) diagnostics has been carried out to reveal that 48 SMGs have at least one reliable counterpart. We derived photometric redshifts of these sources and consequently seven z = 3.1 candidate SMGs are extracted. Two point angular correlation function between LAEs and these SMGs indicate that high density regions at the high redshift universe are the site of SMG/AGN formation. This picture is consistent with predictions from the standard model of hierarchical structure formation.

  2. Are crude oil markets multifractal? Evidence from MF-DFA and MF-SSA perspectives

    NASA Astrophysics Data System (ADS)

    He, Ling-Yun; Chen, Shu-Peng

    2010-08-01

    In this article, we investigated the multifractality and its underlying formation mechanisms in international crude oil markets, namely, Brent and WTI, which are the most important oil pricing benchmarks globally. We attempt to find the answers to the following questions: (1) Are those different markets multifractal? (2) What are the dynamical causes for multifractality in those markets (if any)? To answer these questions, we applied both multifractal detrended fluctuation analysis (MF-DFA) and multifractal singular spectrum analysis (MF-SSA) based on the partition function, two widely used multifractality detecting methods. We found that both markets exhibit multifractal properties by means of these methods. Furthermore, in order to identify the underlying formation mechanisms of multifractal features, we destroyed the underlying nonlinear temporal correlation by shuffling the original time series; thus, we identified that the causes of the multifractality are influenced mainly by a nonlinear temporal correlation mechanism instead of a non-Gaussian distribution. At last, by tracking the evolution of left- and right-half multifractal spectra, we found that the dynamics of the large price fluctuations is significantly different from that of the small ones. Our main contribution is that we not only provided empirical evidence of the existence of multifractality in the markets, but also the sources of multifractality and plausible explanations to current literature; furthermore, we investigated the different dynamical price behaviors influenced by large and small price fluctuations.

  3. Simulation of the MELiSSA closed loop system as a tool to define its integration strategy

    NASA Astrophysics Data System (ADS)

    Poughon, L.; Farges, B.; Dussap, C. G.; Godia, F.; Lasseur, C.

    2009-12-01

    Inspired by a terrestrial ecosystem, Micro-Ecological Life Support System Alternative (MELiSSA) is a project focused on a closed-loop life support system intended for future long-term manned missions (Moon and Mars bases). Started by the ESA in 1989, this 5-compartment concept has evolved through a mechanistic engineering approach designed to acquire both theoretical and technical knowledge. In its current state of development, the project can now start to demonstrate the MELiSSA loop concept at pilot scale. Thus, an integration strategy for a MELiSSA Pilot Plant (MPP) has been defined, describing the different test phases and connections between compartments. The integration steps are due to be started in 2008 and completed with a complete operational loop in 2015. The ultimate objective is to achieve a closed liquid and gas loop fulfiling 100% of oxygen requirements and at least 20% of food requirements for one-man. Although the integration logic could start with the most advanced processes in terms of knowledge and hardware development, this logic needs to be expanded to encompass a high-level simulation policy. This simulation exercise will make it possible to run effective demonstrations of each independent process, followed by progressive coupling with other processes in operational conditions mirroring as far as possible the final configuration. The theoretical approach described in this paper is based on mass balance models of each MELiSSA compartment which are used to simulate each integration step and the complete MPP loop itself. These simulations will help identify criticalities in each integration step and check consistency between objectives, flows, recycling efficiencies and sizing of the pilot reactors. An MPP scenario compatible with current knowledge on the operation of the pilot reactors was investigated, and the theoretical performances of the system were compared against the objectives assigned to the MPP. This scenario makes it possible to

  4. Imaging of diffuse H I absorption structure in the SSA22 proto-cluster region at z = 3.1

    NASA Astrophysics Data System (ADS)

    Mawatari, Ken; Inoue, Akio K.; Yamada, Toru; Hayashino, Tomoki; Otsuka, Takuya; Matsuda, Yuichi; Umehata, Hideki; Ouchi, Masami; Mukae, Shiro

    2017-01-01

    Using galaxies as background light sources to map intervening Lyα absorption is a novel approach to study the interplay among galaxies, the circum-galactic medium (CGM), and the intergalactic medium (IGM). Introducing a new measure of z = 3.1 H I Lyα absorption relative to the cosmic mean, ΔNB497, estimated from photometric data of star-forming galaxies at 3.3 ⪉ z ⪉ 3.5, we have made two-dimensional ΔNB497 maps in the z = 3.1 SSA22 proto-cluster region and two control fields (SXDS and GOODS-N fields) with a spatial resolution of ˜5 comoving Mpc. The ΔNB497 measurements in the SSA22 field are systematically larger than those in the control fields, and this H I absorption enhancement extends more than 50 comoving Mpc. The field-averaged (i.e., ˜50 comoving Mpc scale) ΔNB497 and the overdensity of Lyα emitters (LAEs) seem to be correlated, while there is no clear dependency of the ΔNB497 on the local LAE overdensity in a few comoving Mpc scale. These results suggest that diffuse H I gas spreads out in/around the SSA22 proto-cluster. We have also found an enhancement of ΔNB497 at a projected distance <100 physical kpc from the nearest z = 3.1 galaxies at least in the SSA22 field, which is probably due to H I gas associated with the CGM of individual galaxies. The H I absorption enhancement in the CGM-scale tends to be weaker around galaxies with stronger Lyα emission, which suggests that the Lyα escape fraction from galaxies depends on hydrogen neutrality in the CGM.

  5. Imaging of diffuse H I absorption structure in the SSA22 protocluster region at z = 3.1

    NASA Astrophysics Data System (ADS)

    Mawatari, Ken; Inoue, Akio K.; Yamada, Toru; Hayashino, Tomoki; Otsuka, Takuya; Matsuda, Yuichi; Umehata, Hideki; Ouchi, Masami; Mukae, Shiro

    2017-06-01

    Using galaxies as background light sources to map intervening Ly α absorption is a novel approach to study the interplay among galaxies, the circumgalactic medium (CGM) and the intergalactic medium. Introducing a new measure of z = 3.1 H I Ly α absorption relative to the cosmic mean, ΔNB497, estimated from photometric data of star-forming galaxies at 3.3 ≲ z ≲ 3.5, we have made two-dimensional ΔNB497 maps in the z = 3.1 SSA22 protocluster region and two control fields (Subaru/XMM-Newton Deep Survey; Great Observatory Optical Deep Survey North) with a spatial resolution of ˜5 comoving Mpc. The ΔNB497 measurements in the SSA22 field are systematically larger than those in the control fields, and this H I absorption enhancement extends more than 50 comoving Mpc. The field-averaged (i.e. ˜50 comoving Mpc scale) ΔNB497 and the overdensity of Ly α emitters (LAEs) seem to be correlated, while there is no clear dependency of the ΔNB497 on the local LAE overdensity in a few comoving Mpc scale. These results suggest that diffuse H I gas spreads out in/around the SSA22 protocluster. We have also found an enhancement of ΔNB497 at a projected distance <100 physical kpc from the nearest z = 3.1 galaxies at least in the SSA22 field, which is probably due to H I gas associated with the CGM of individual galaxies. The H I absorption enhancement in the CGM-scale tends to be weaker around galaxies with stronger Ly α emission, which suggests that the Ly α escape fraction from galaxies depends on hydrogen neutrality in the CGM.

  6. Simulation of the MELiSSA closed loop system as a tool to define its integration strategy

    NASA Astrophysics Data System (ADS)

    Poughon, Laurent; Farges, Berangere; Dussap, Claude-Gilles; Godia, Francesc; Lasseur, Christophe

    Inspired from a terrestrial ecosystem, MELiSSA (Micro Ecological Life Support System Alternative) is a project of closed life support system future long-term manned missions (Moon and Mars bases). Started on ESA in 1989, this 5 compartments concept has evolved following a mechanistic engineering approach for acquiring both theoretical and technical knowledge. In its current state of development the project can now start to demonstrate the MELiSSA loop concept at a pilot scale. Thus an integration strategy for a MELiSSA Pilot Plant (MPP) was defined, describing the different phases for tests and connections between compartments. The integration steps should be started in 2008 and be completed with a complete operational loop in 2015, which final objective is to achieve a closed liquid and gas loop with 100 Although the integration logic could start with the most advanced processes in terms of knowledge and hardware development, this logic needs to be completed by high politic of simulation. Thanks to this simulation exercise, the effective demonstrations of each independent process and its progressive coupling with others will be performed in operational conditions as close as possible to the final configuration. The theoretical approach described in this paper is based on mass balance models of each of the MELiSSA biological compartments which are used to simulate each integration step and the complete MPP loop itself. These simulations will help to identify criticalities of each integration steps and to check the consistencies between objectives, flows, recycling efficiencies and sizing of the pilot reactors. A MPP scenario compatible with the current knowledge of the operation of the pilot reactors was investigated and the theoretical performances of the system compared to the objectives of the MPP. From this scenario the most important milestone steps in the integration are highlighted and their behaviour can be simulated.

  7. Spontaneous rupture of atrioventricular valve tensor apparatus as late manifestation of anti-Ro/SSA antibody-mediated cardiac disease.

    PubMed

    Cuneo, Bettina F; Fruitman, Deborah; Benson, D Woodrow; Ngan, Bo-Yee; Liske, Michael R; Wahren-Herlineus, Marie; Ho, S Yen; Jaeggi, Edgar

    2011-03-01

    Atrioventricular (AV) block and endocardial fibroelastosis associated with dilated cardiomyopathy are the most common clinical manifestations of anti-Ro/SSA-mediated fetal cardiac disease. Valvar dysfunction has not been a prominent feature of this disease; however, recent anecdotal cases have suggested an association between rupture of the AV valve tensor apparatus and maternal anti-Ro/SSA antibodies. In the present study, we have described the clinical and laboratory findings and reviewed the published data for infants of anti-Ro/SSA-positive pregnancies with AV valve insufficiency due to chordal rupture from the papillary muscles. The histopathologic features of the papillary muscle and ventricular free wall and septum biopsy specimens were examined and compared to the sections of AV leaflets from 6 autopsied fetuses with anti-Ro/SSA-mediated complete AV block without chordal disruption. Specific epitopes to the p200 region of Ro52, and Ro60 antibodies were evaluated in cases with chordal rupture. Severe AV valve insufficiency was detected prenatally (as early as 34 weeks of gestation) or postnatally (as late as 182 days) after areas of patchy echogenicity were noted in the papillary muscle at 19 to 22 weeks of gestation. Postnatally, urgent valve surgery was performed in 5 of 6 patients; 1 of 6 patients died preoperatively. All patients tested positive for Ro52. Valve leaflet tissue from the autopsy specimens was normal. The ventricular free wall and septum biopsy specimens from a patient with chordal rupture showed normal tissue; however, the papillary muscle biopsy specimens demonstrated severe atrophy with near total replacement of myocytes by fibrosis and dystrophic calcifications, and negative immunochemistry findings. In conclusion, these findings have defined an underappreciated complication of fetal antibody-mediated cardiac inflammation. Copyright © 2011 Elsevier Inc. All rights reserved.

  8. Outcome in 212 anti-Ro/SSA-positive pregnancies and population-based incidence of congenital heart block.

    PubMed

    Skog, Amanda; Lagnefeldt, Linda; Conner, Peter; Wahren-Herlenius, Marie; Sonesson, Sven-Erik

    2016-01-01

    We investigated the effects of maternal autoimmune disease and fetal congenital heart block (CHB) on pregnancy outcomes in anti-Ro/SSA-positive women and assessed the population-based incidence of isolated CHB. One hundred and ninety nine anti-Ro/SSA-positive pregnancies were prospectively followed at our center (2000-2013). Seven fetuses developed atrioventricular block (AVB) II-III. In this period, another 13 anti-Ro/SSA-positive pregnancies were referred for fetal bradycardia, subsequently diagnosed with AVB II-III. Cesarean section rates, gestational age, body measurements at birth, and the incidence of CHB in these 212 pregnancies were analyzed in relation to fetal atrioventricular conduction and maternal diagnosis and compared with data from the Medical Birth Registry on 352,104 pregnancies in the Stockholm County. The prevalence of maternal systemic lupus erythematosus (SLE) and primary Sjögren's syndrome and the outcomes at birth were similar in normal conduction and AVB I cases. Only 1/20 AVB II-III cases (0/7 in the surveillance group) had a mother diagnosed with SLE, compared with 73/192 in cases with normal conduction or AVB I. Excluding cases with AVB II-III, SLE mothers more frequently delivered by cesarean section (31% vs. 20%, p < 0.05) and had a higher incidence of preterm birth (13% vs. 5.8%, p < 0.05) than the county population. Both SLE and primary Sjögren's syndrome mothers had a fourfold greater rate of growth-retarded babies (10.11% vs. 2.2%, p < 0.001). The incidence of autoantibody-related AVB II-III in Stockholm County was 1/23 300. This study of CHB provides new information on the incidence of CHB and outcome of pregnancy in anti-Ro/SSA-positive women, which has clinical relevance when counseling rheumatic patients considering pregnancy. © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.

  9. Autoantibodies from mice exposed to Libby amphibole asbestos bind SSA/Ro52 – enriched apoptotic blebs of murine macrophages

    PubMed Central

    Blake, David J.; Wetzel, Scott A.; Pfau, Jean C.

    2008-01-01

    Asbestos exposure is associated with increased autoimmune responses in humans. For example, in Libby, MT where significant asbestos exposure has occurred due to an asbestos contaminated vermiculite mine near the community, residents have developed increased autoimmune responses compared to an unexposed population. However, the exact mechanism by which Libby amphibole asbestos generates autoimmune responses is unclear. A murine model of amphibole asbestos-induced autoimmunity was recently established, and one of the targets of the autoantibodies was the SSA/Ro52 autoantigen. The purpose of this study was to determine whether the SSA/Ro52 autoantigen is exposed at the surface of cells as a result of asbestos exposure as a possible mechanism leading to antigenicity. Our results indicate that Libby asbestos induces apoptosis in murine macrophages as determined by phosphatidylserine exposure, cleavage of poly (ADP-ribose) polymerase and morphological changes such as nuclear condensation. Moreover, asbestos induced apoptosis results in the formation of apoptotic cell surface blebs enriched in SSA/Ro52 as determined by confocal microscopy. Most importantly, apoptotic cell surface blebs are recognized by autoantibodies from mice exposed to amphibole asbestos suggesting that these cell surface structures may be antigenic when presented in a pro-inflammatory context. This study supports the hypothesis that the induction of apoptosis plays a key role in environmentally-induced autoimmunity through cell surface exposure of a known autoantigen. PMID:18295955

  10. Atrioventricular Conduction Delay in Fetuses Exposed to Anti-SSA/Ro and Anti-SSB/La Antibodies: A Magnetocardiography Study

    PubMed Central

    Wacker-Gußmann, Annette; Paulsen, Henrike; Kiefer-Schmidt, Isabelle; Henes, Joerg; Muenssinger, Jana; Weiss, Magdalene; Goelz, Rangmar; Preissl, Hubert

    2012-01-01

    Background. The presence of anti-SSA/Ro and anti-SSB/La antibodies during pregnancy is associated with fetal congenital heart block (CHB), which is primarily diagnosed through fetal echocardiography. Conclusive information about the complete electrophysiology of the fetal cardiac conducting system is still lacking. In addition to echocardiography, fetal magnetocardiography (fMCG) can be used. fMCG is the magnetic analogue of the fetal electrocardiogram (ECG). Patients and Methods. Forty-eight pregnant women were enrolled in an observational study; 16 of them tested positive for anti-SSA/Ro and anti-SSB/La antibodies. In addition to routine fetal echocardiography, fMCG was used. Fetal cardiac time intervals (fCTIs) were extracted from the magnetic recordings by predefined procedures. ECGs in the neonates of the study group were performed within the first month after delivery. Results. The PQ segment of the fCTI was significantly prolonged in the study group (P = 0.007), representing a delay of the electrical impulse in the atrioventricular (AV) node. Other fCTIs were within normal range. None of the anti-SSA/Ro and/or anti-SSB/La fetuses progressed to a more advanced heart block during pregnancy or after birth. Conclusion. The study identified a low-risk population within antibody positive mothers, where PQ segment prolongation is associated with a lack of progression of the disease. PMID:23320018

  11. Commercial Space Situational Awareness: An investigation of Ground-based SSA Concepts to Support Commercial GEO Satellite Operators

    NASA Astrophysics Data System (ADS)

    Skinner, M.; Kelecy, T.; Gregory, S.; Toth, J.; Liang, D.; Yamanaka, D.; Kent, S.; Tjoelker, R.; Margineantu, D.; Allison, A.; Heiberg, C.

    2013-09-01

    The geostationary Earth orbit (GEO) satellite belt is a unique place above the earth affording a continuous line-of-sight to satellite uplink and downlink stations. The volume defined by this belt is large, but available slots are limited. During the course of the space age, this volume has become more crowded, as humankind has launched more and more satellites into this particular orbital regime, and satellites that suffered incapacitating anomalies and space debris have remained in the belt. The latter pose a hazard since they are uncontrolled, and with no capability for debris removal, the only way for satellite operators to avoid collisions with space objects is to maneuver. Knowing when and where to maneuver requires space situational awareness (SSA). Discussions with commercial satellite operators have led us to see the need for a new targeted source of observations of both active satellites, as well as space debris and inactive satellites, in this orbital regime. This presentation reports on an investigation of the applicability of well-established SSA approaches to support the interests of commercial GEO satellite owner-operators. We identify prominent issues and concerns of the commercial satellite community and explore ground-based SSA methods to address these interests.

  12. Dynamic aspects and controllability of the MELiSSA project: a bioregenerative system to provide life support in space.

    PubMed

    Farges, Bérangère; Poughon, Laurent; Creuly, Catherine; Cornet, Jean-François; Dussap, Claude-Gilles; Lasseur, Christophe

    2008-12-01

    Manmade ecosystems differ from their prototype biosphere by the principle of control. The Earth Biosphere is sustainable by stochastic control and very large time constants. By contrast, in a closed ecosystem such as the micro-ecological life support system alternative (MELiSSA system) developed by the European Space Agency for space exploration, a deterministic control is a prerequisite of sustainable existence. MELiSSA is an integrated sum of interconnected biological subsystems. On one hand, all unit operations in charge of the elementary functions constitutive of the entire life support system are studied until a thorough understanding and mathematical modelling. On the other hand, the systemic approach of complex, highly branched systems with feedback loops is performed. This leads to study in the same perspective, with the same degree of accuracy and with the same language, waste degradation, water recycling, atmosphere revitalisation and food production systems prior to the integration of knowledge-based control models. This paper presents the mathematical modelling of the MELiSSA system and the interface between the control strategy of the entire system and the control of the bioreactors.

  13. Cryptococcal heat shock protein 70 homolog Ssa1 contributes to pulmonary expansion of Cryptococcus neoformans during the afferent phase of the immune response by promoting macrophage M2 polarization.

    PubMed

    Eastman, Alison J; He, Xiumiao; Qiu, Yafeng; Davis, Michael J; Vedula, Priya; Lyons, Daniel M; Park, Yoon-Dong; Hardison, Sarah E; Malachowski, Antoni N; Osterholzer, John J; Wormley, Floyd L; Williamson, Peter R; Olszewski, Michal A

    2015-06-15

    Numerous virulence factors expressed by Cryptococcus neoformans modulate host defenses by promoting nonprotective Th2-biased adaptive immune responses. Prior studies demonstrate that the heat shock protein 70 homolog, Ssa1, significantly contributes to serotype D C. neoformans virulence through the induction of laccase, a Th2-skewing and CNS tropic factor. In the present study, we sought to determine whether Ssa1 modulates host defenses in mice infected with a highly virulent serotype A strain of C. neoformans (H99). To investigate this, we assessed pulmonary fungal growth, CNS dissemination, and survival in mice infected with either H99, an SSA1-deleted H99 strain (Δssa1), and a complement strain with restored SSA1 expression (Δssa1::SSA1). Mice infected with the Δssa1 strain displayed substantial reductions in lung fungal burden during the innate phase (days 3 and 7) of the host response, whereas less pronounced reductions were observed during the adaptive phase (day 14) and mouse survival increased only by 5 d. Surprisingly, laccase activity assays revealed that Δssa1 was not laccase deficient, demonstrating that H99 does not require Ssa1 for laccase expression, which explains the CNS tropism we still observed in the Ssa1-deficient strain. Lastly, our immunophenotyping studies showed that Ssa1 directly promotes early M2 skewing of lung mononuclear phagocytes during the innate phase, but not the adaptive phase, of the immune response. We conclude that Ssa1's virulence mechanism in H99 is distinct and laccase-independent. Ssa1 directly interferes with early macrophage polarization, limiting innate control of C. neoformans, but ultimately has no effect on cryptococcal control by adaptive immunity.

  14. Acting Atoms.

    ERIC Educational Resources Information Center

    Farin, Susan Archie

    1997-01-01

    Describes a fun game in which students act as electrons, protons, and neutrons. This activity is designed to help students develop a concrete understanding of the abstract concept of atomic structure. (DKM)

  15. Kinetic Atom.

    ERIC Educational Resources Information Center

    Wilson, David B.

    1981-01-01

    Surveys the research of scientists like Joule, Kelvin, Maxwell, Clausius, and Boltzmann as it comments on the basic conceptual issues involved in the development of a more precise kinetic theory and the idea of a kinetic atom. (Author/SK)

  16. Acting Atoms.

    ERIC Educational Resources Information Center

    Farin, Susan Archie

    1997-01-01

    Describes a fun game in which students act as electrons, protons, and neutrons. This activity is designed to help students develop a concrete understanding of the abstract concept of atomic structure. (DKM)

  17. Kinetic Atom.

    ERIC Educational Resources Information Center

    Wilson, David B.

    1981-01-01

    Surveys the research of scientists like Joule, Kelvin, Maxwell, Clausius, and Boltzmann as it comments on the basic conceptual issues involved in the development of a more precise kinetic theory and the idea of a kinetic atom. (Author/SK)

  18. Ground Optical Signal Processing Architecture for Contributing SSA Space Based Sensor Data

    NASA Astrophysics Data System (ADS)

    Koblick, D.; Klug, M.; Goldsmith, A.; Flewelling, B.; Jah, M.; Shanks, J.; Piña, R.

    2014-09-01

    The main objective of the DARPA program Orbit Outlook (O^2) is to improve the metric tracking and detection performance of the Space Situational Network (SSN) by adding a diverse low-cost network of contributing sensors to the Space Situational Awareness (SSA) mission. In order to accomplish this objective, not only must a sensor be in constant communication with a planning and scheduling system to process tasking requests, there must be an underlying framework to provide useful data products, such as angles only measurements. Existing optical signal processing implementations such as the Optical Processing Architecture at Lincoln (OPAL) are capable of converting mission data collections to angles only observations, but may be difficult for many users to obtain, support, and customize for low-cost missions and demonstration programs. The Ground Optical Signal Processing Architecture (GOSPA) will ingest raw imagery and telemetry data from a space based electro optical sensor and perform a background removal process to remove anomalous pixels, interpolate over bad pixels, and dominant temporal noise. After background removal, the streak end points and target centroids are located using a corner detection algorithm developed by Air Force Research Laboratory. These identified streak locations are then fused with the corresponding spacecraft telemetry data to determine the Right Ascension and Declination measurements with respect to time. To demonstrate the performance of GOSPA, non-rate tracking collections against a satellite in Geosynchronous Orbit are simulated from a visible optical imaging sensor in a polar Low Earth Orbit. Stars, noise and bad pixels are added to the simulated images based on look angles and sensor parameters. These collections are run through the GOSPA framework to provide angles- only measurements to the Air Force Research Laboratory Constrained Admissible Region Multiple Hypothesis Filter (CAR-MHF) in which an Initial Orbit Determination is

  19. Automatic, Rapid Replanning of Satellite Operations for Space Situational Awareness (SSA)

    NASA Astrophysics Data System (ADS)

    Stottler, D.; Mahan, K.

    An important component of Space Situational Awareness (SSA) is knowledge of the status and tasking of blue forces (e.g. satellites and ground stations) and the rapid determination of the impacts of real or hypothetical changes and the ability to quickly replan based on those changes. For example, if an antenna goes down (either for benign reasons or from purposeful interference) determining which missions will be impacted is important. It is not simply the set of missions that were scheduled to utilize that antenna, because highly expert human schedulers will respond to the outage by intelligently replanning the real-time schedule. We have developed an automatic scheduling and deconfliction engine, called MIDAS (for Managed Intelligent Deconfliction And Scheduling) that interfaces to the current legacy system (ESD 2.7) which can perform this replanning function automatically. In addition to determining the impact of failed resources, MIDAS can also replan in response to a satellite under attack. In this situation, additional supports must be quickly scheduled and executed (while minimizing impacts to other missions). Because MIDAS is a fully automatic system, replacing a current human labor-intensive process, and provides very rapid turnaround (seconds) it can also be used by commanders to consider what-if questions and focus limited protection resources on the most critical resources. For example, the commander can determine the impact of a successful attack on one of two ground stations and place heavier emphasis on protecting the station whose loss would create the most severe impacts. The system is currently transitioning to operational use. The MIDAS system and its interface to the legacy ESD 2.7 system will be described along with the ConOps for different types of detailed operational scenarios.

  20. Relation of Sensory Peripheral Neuropathy in Sjögren Syndrome to anti-Ro/SSA

    PubMed Central

    Scofield, Amanda K.; Radfar, Lida; Ice, John; Vista, Evan; Anaya, Juan-Manuel; Houston, Glen; Lewis, David; Stone, Donald U.; Chodosh, James; Hefner, Kimberly; Lessard, Christopher J.; Moser, Kathy L.; Scofield, R. Hal

    2013-01-01

    Background Sjögren syndrome is a common, chronic autoimmune disease that typically produces inflammation and poor function of the salivary and lacrimal glands. Other organs can be affected, including the nervous system. Sensory peripheral neuropathy is a common manifestation of the disease. Methods Eight-eight patients attending a dry eyes-dry mouth clinic were classified as primary Sjögren syndrome and underwent a neurological examination. Anti-Ro (or SSA) and anti-La (or SSB) were determined using immunodiffusion as well as Inno-Lia and BioPlex ANA screen. Serum vitamin B12 levels were determined using an enzyme-linked microtiter plate assay. Results Twenty-seven (31%) of the 88 patients had peripheral neuropathy as defined by loss of light touch, proprioception or vibratory sensation. Anti-Ro and anti-La were found by immunodiffusion in 12 patients, and 8 of these 12 had neuropathy (χ2=8.46, p=0.0036, odds ratio = 6.0 compared to those without precipitating anti-Ro and anti-La). Of the 27 patients with only anti-Ro by immunodiffusion, 13 (48.1%) of these had neuropathy (χ2 =5.587, p=0.018 compared to those without anti-Ro). There was no relationship of the other, more sensitive measures of anti-Ro and anti-La to neuropathy. In addition, we found no association of serum vitamin B12 levels to neuropathy among these patients with Sjögren syndrome. Conclusion Sensory peripheral neuropathy is common among patients with Sjögren syndrome, and is associated with the presence of anti-Ro and anti-La when determined by immunodiffusion. PMID:22955477

  1. Searching for candidates of Lyman continuum sources - revisiting the SSA22 field

    NASA Astrophysics Data System (ADS)

    Micheva, Genoveva; Iwata, Ikuru; Inoue, Akio K.; Matsuda, Yuichi; Yamada, Toru; Hayashino, Tomoki

    2017-02-01

    We present the largest to date sample of hydrogen Lyman continuum (LyC) emitting galaxy candidates at any redshift, with 18 Lyman α emitters (LAEs) and seven Lyman break galaxies (LBGs), obtained from the SSA22 field with Subaru/Suprime-Cam. The sample is based on the 159 LAEs and 136 LBGs observed in the field, all with spectroscopically confirmed redshifts, and these LyC candidates are selected as galaxies with counterparts in a narrow-band filter image which traces LyC at z ≥ 3.06. Many LyC candidates show a spatial offset between the rest-frame non-ionizing ultraviolet (UV) detection and the LyC-emitting substructure or between the Lyα emission and LyC. The possibility of foreground contamination complicates the analysis of the nature of LyC emitters, although statistically it is highly unlikely that all candidates in our sample are contaminated by foreground sources. Many viable LyC LAE candidates have flux density ratios inconsistent with standard models, while also having too blue UV slopes to be foreground contaminants. Stacking reveals no significant LyC detection, suggesting that there is a dearth of objects with marginal LyC signal strength, perhaps due to a bimodality in the LyC emission. The foreground contamination corrected 3σ upper limits of the observed average flux density ratios are fLyC/fUV < 0.08 from stacking LAEs and fLyC/fUV < 0.02 from stacking LBGs. There is a sign of a positive correlation between LyC and Lyα, suggesting that both types of photons escape via a similar mechanism. The LyC detection rate among protocluster LBGs is seemingly lower compared to the field.

  2. ALMA Deep Field in SSA22: Source Catalog and Number Counts

    NASA Astrophysics Data System (ADS)

    Umehata, Hideki; Tamura, Yoichi; Kohno, Kotaro; Ivison, R. J.; Smail, Ian; Hatsukade, Bunyo; Nakanishi, Kouichiro; Kato, Yuta; Ikarashi, Soh; Matsuda, Yuichi; Fujimoto, Seiji; Iono, Daisuke; Lee, Minju; Steidel, Charles C.; Saito, Tomoki; Alexander, D. M.; Yun, Min S.; Kubo, Mariko

    2017-01-01

    We present results from a deep 2‧ × 3‧ (comoving scale of 3.7 Mpc × 5.5 Mpc at z = 3) survey at 1.1 mm, taken with the Atacama Large Millimeter/submillimeter Array (ALMA) in the SSA22 field. We observe the core region of a z = 3.09 protocluster, achieving a typical rms sensitivity of 60 μJy beam-1 at a spatial resolution of 0.″7. We detect 18 robust ALMA sources at a signal-to-noise ratio (S/N) > 5. Comparison between the ALMA map and a 1.1 mm map, taken with the AzTEC camera on the Atacama Submillimeter Telescope Experiment (ASTE), indicates that three submillimeter sources discovered by the AzTEC/ASTE survey are resolved into eight individual submillimeter galaxies (SMGs) by ALMA. At least 10 of our 18 ALMA SMGs have spectroscopic redshifts of z ≃ 3.09, placing them in the protocluster. This shows that a number of dusty starburst galaxies are forming simultaneously in the core of the protocluster. The nine brightest ALMA SMGs with S/N > 10 have a median intrinsic angular size of 0\\buildrel{\\prime\\prime}\\over{.} {32}-0.06+0.13 ({2.4}-0.4+1.0 physical kpc at z = 3.09), which is consistent with previous size measurements of SMGs in other fields. As expected, the source counts show a possible excess compared to the counts in the general fields at S1.1mm ≥ 1.0 mJy, due to the protocluster. Our contiguous mm mapping highlights the importance of large-scale structures on the formation of dusty starburst galaxies.

  3. Obstetric and perinatal outcome in anti-Ro/SSA-positive pregnant women: a prospective cohort study.

    PubMed

    Martínez-Sánchez, Nuria; Pérez-Pinto, Sergio; Robles-Marhuenda, Ángel; Arnalich-Fernández, Francisco; Martín Cameán, María; Hueso Zalvide, Edurne; Bartha, Jose Luis

    2017-04-01

    Anti-Ro/SS-A is one specific type of antinuclear antibodies. They are in the majority of cases associated with primary Sjögren syndrome (SS) but also in Systemic Lupus Erythematosus (SLE), rheumatoid arthritis (RA), and in healthy people. During pregnancy, they are mainly associated to congenital heart block (CHB) and neonatal lupus (NL). The aim of this study was to compare the rate of maternal and fetal complications between a series of anti-Ro/SS-A positive pregnant women prospectively followed. Forty-two anti-Ro/SSA antibodies positive pregnant women that were referred to our hospital between 2011 and 2015. Data about pregnancy follow-up and outcomes were prospectively recorded from electronic databases. Data included demographic characteristics of the patients and their diseases (type, treatments, profile of anti-Ro/SSA, and antiphospholipid antibodies), pregnancy complications (CHB, preeclampsia, preterm delivery), ultrasound examinations and conditions, and mode of delivery. Maternal age was 35.22 ± 3.42 years and most of them were either SLE (n = 16, 40%) or Sjögren syndrome (n = 15, 37.5%). The rest of them were asymptomatic carriers (n = 8; 20%), and there was only one case of rheumatoid arthritis (n = 1; 2.5%). The incidence of anti-Ro52 and anti-Ro60 positive was n = 13, 82.4% and n = 16, 100%, respectively. Anti-La/SSB antibodies were present in n = 17, 48,6% of the patients. Half of the patients were taking hydroxycloroquine (n = 18, 45%). Seven pregnancies were complicated by fetal anti-Ro-related cardiac disease (17.9%) including four cases (57.1%) of second-degree heart block, two cases of third degree heart block (28.6%) and one case (14.3%) of intense and diffuse hyperechogenicity in atrioventricular valves without heart block. Gestational age at diagnosis of these conditions was 23.2 ± 3.5 weeks. One of the 18 patients having hydroxychloroquine (5.6%) compared with the six of them in women not having this medication (6

  4. NPPy With Dan DeVito

    NASA Image and Video Library

    The NPP mission mascot NPPy was found by the NPP Ground Project Manager Dan DeVito in a place called Svalbard, located 600 miles from the North Pole. Since then, Dan and other people on the NPP pro...

  5. Atomic research

    NASA Technical Reports Server (NTRS)

    Hadaway, James B.; Connatser, Robert; Cothren, Bobby; Johnson, R. B.

    1993-01-01

    Work performed by the University of Alabama in Huntsville's (UAH) Center for Applied Optics (CAO) entitled Atomic Research is documented. Atomic oxygen (AO) effects on materials have long been a critical concern in designing spacecraft to withstand exposure to the Low Earth Orbit (LEO) environment. The objective of this research effort was to provide technical expertise in the design of instrumentation and experimental techniques for analyzing materials exposed to atomic oxygen in accelerated testing at NASA/MSFC. Such testing was required to answer fundamental questions concerning Space Station Freedom (SSF) candidate materials and materials exposed to atomic oxygen aboard the Long-Duration Exposure Facility (LDEF). The primary UAH task was to provide technical design, review, and analysis to MSFC in the development of a state-of-the-art 5eV atomic oxygen beam facility required to simulate the RAM-induced low earth orbit (LEO) AO environment. This development was to be accomplished primarily at NASA/MSFC. In support of this task, contamination effects and ultraviolet (UV) simulation testing was also to be carried out using NASA/MSFC facilities. Any materials analysis of LDEF samples was to be accomplished at UAH.

  6. Atom Interferometry

    ScienceCinema

    Mark Kasevich

    2016-07-12

    Atom de Broglie wave interferometry has emerged as a tool capable of addressing a diverse set of questions in gravitational and condensed matter physics, and as an enabling technology for advanced sensors in geodesy and navigation. This talk will review basic principles, then discuss recent applications and future directions. Scientific applications to be discussed include measurement of G (Newton’s constant), tests of the Equivalence Principle and post-Newtonian gravity, and study of the Kosterlitz-Thouless phase transition in layered superfluids. Technology applications include development of precision gryoscopes and gravity gradiometers. The talk will conclude with speculative remarks looking to the future: Can atom interference methods be sued to detect gravity waves? Can non-classical (entangled/squeezed state) atom sources lead to meaningful sensor performance improvements?

  7. Atom Interferometry

    SciTech Connect

    Mark Kasevich

    2008-05-07

    Atom de Broglie wave interferometry has emerged as a tool capable of addressing a diverse set of questions in gravitational and condensed matter physics, and as an enabling technology for advanced sensors in geodesy and navigation. This talk will review basic principles, then discuss recent applications and future directions. Scientific applications to be discussed include measurement of G (Newton’s constant), tests of the Equivalence Principle and post-Newtonian gravity, and study of the Kosterlitz-Thouless phase transition in layered superfluids. Technology applications include development of precision gryoscopes and gravity gradiometers. The talk will conclude with speculative remarks looking to the future: Can atom interference methods be sued to detect gravity waves? Can non-classical (entangled/squeezed state) atom sources lead to meaningful sensor performance improvements?

  8. Atom Interferometry

    SciTech Connect

    Kasevich, Mark

    2008-05-08

    Atom de Broglie wave interferometry has emerged as a tool capable of addressing a diverse set of questions in gravitational and condensed matter physics, and as an enabling technology for advanced sensors in geodesy and navigation. This talk will review basic principles, then discuss recent applications and future directions. Scientific applications to be discussed include measurement of G (Newton's constant), tests of the Equivalence Principle and post-Newtonian gravity, and study of the Kosterlitz-Thouless phase transition in layered superfluids. Technology applications include development of precision gyroscopes and gravity gradiometers. The talk will conclude with speculative remarks looking to the future: Can atom interference methods be used to detect gravity waves? Can non-classical (entangled/squeezed state) atom sources lead to meaningful sensor performance improvements?

  9. Anti-SSA Ro52/Ro60 antibody testing by immunodot could help the diagnosis of Sjogren's syndrome in the absence of anti-SSA/SSB antibodies by ELISA.

    PubMed

    Mekinian, Arsène; Nicaise-Roland, Pascale; Chollet-Martin, Sylvie; Fain, Olivier; Crestani, Bruno

    2013-12-01

    The objective of this study was to assess the diagnostic value of anti-Ro52/60 antibodies by immunodot in patients with suspected SS. All patients between 2008 and 2012 with suspected SS without anti-SSA/SSB antibodies by ELISA and who had a determination of anti-SSA (Ro52/Ro60) antibodies by immunodot (Euroimmun, Germany) were retrospectively analysed. Eighty-four patients (median age 62 years; males 35 cases) were included. Forty-five patients had associated interstitial lung disease (ILD). American-European Consensus Group (AECG) criteria for SS were fulfilled in 10 patients (12%) with a positive salivary gland biopsy, and among them 2 patients had anti-Ro52 antibodies by dot (20%). Among 74 patients with a negative salivary gland biopsy, 16 (22%) had anti-Ro52/60 antibodies and 10 (14%) fulfilled AECG criteria when including Ro52/60 antibodies. A comparison of patients with and without anti-Ro52/60 antibodies revealed no differences, except gamma globulin levels and more frequent steroid use in patients with anti-Ro52/60 antibodies (P < 0.05). In 45 patients with ILD and dry eye/mouth syndrome, 10 (22%) had positive anti-Ro52/60 antibodies. In these patients 2 (4%) fulfilled AECG criteria without anti-Ro52/60 antibodies vs 4 (8%) patients if anti-Ro52/60 antibodies were included. In patients with dry eye/mouth syndrome without anti-SSA/SSB antibodies by ELISA, the detection of anti-Ro52/Ro60 antibodies by dot could help in the diagnosis of SS. In patients with ILD, the lower frequency of a Chisholm score ≥3 enhances the interest of anti-Ro52/Ro60 screening.

  10. New coupled-particle light-scattering assay for detection of Ro/SSA (52 and 60 kilodaltons) and La/SSB autoantibodies in connective tissue diseases.

    PubMed

    Bizzaro, N; Bonelli, F; Tonutti, E; Tozzoli, R; Villalta, D

    2001-09-01

    The diagnostic and analytical performance of the coupled-particle light-scattering assay in detecting anti-Ro/SSA autoantibodies (the 60-kDa [Ro60] and the 52-kDa [Ro52] antibodies) and anti-La/SSB autoantibodies was evaluated. The antigens were obtained by recombinant DNA procedures to include the most immunogenic epitopes for each protein by using a prokaryotic expression system. Serum samples from 151 patients with connective tissue diseases and 52 control subjects (including patients with viral infections, patients with Lyme disease, and healthy subjects) were studied. Sensitivities for detection of anti-Ro/SSA and anti-La/SSB were 88.2 and 95.2%, respectively; specificities were 97.6 and 98.1%, respectively. The intra-assay coefficient of variation (CV) ranged from 4.3 to 10.9% for anti-Ro/SSA and from 2.8 to 12.5% for anti-La/SSB; interassay CVs ranged from 6.5 to 13.2% and from 8.2 to 14.5%, respectively. Among the anti-Ro/SSA-positive samples, Ro60 was recognized by 66% of the test sera and Ro52 was recognized by 95% of the test sera. Thirty-four percent of the Ro/SSA-positive sera were reactive only with the Ro52 antigen, indicating that anti-Ro52 is the most common antibody specificity recognized by anti-Ro/SSA autoantibodies. No differences were found between the prevalences of anti-Ro60 and anti-Ro52 in relation to systemic lupus erythematosus or Sjögren's syndrome. The results of the present study indicate that this new immunoassay is an efficient diagnostic tool for the detection of anti-Ro/SSA and anti-La/SSB antibodies in patients with autoimmune disorders.

  11. New Coupled-Particle Light-Scattering Assay for Detection of Ro/SSA (52 and 60 Kilodaltons) and La/SSB Autoantibodies in Connective Tissue Diseases

    PubMed Central

    Bizzaro, Nicola; Bonelli, Fabrizio; Tonutti, Elio; Tozzoli, Renato; Villalta, Danilo

    2001-01-01

    The diagnostic and analytical performance of the coupled-particle light-scattering assay in detecting anti-Ro/SSA autoantibodies (the 60-kDa [Ro60] and the 52-kDa [Ro52] antibodies) and anti-La/SSB autoantibodies was evaluated. The antigens were obtained by recombinant DNA procedures to include the most immunogenic epitopes for each protein by using a prokaryotic expression system. Serum samples from 151 patients with connective tissue diseases and 52 control subjects (including patients with viral infections, patients with Lyme disease, and healthy subjects) were studied. Sensitivities for detection of anti-Ro/SSA and anti-La/SSB were 88.2 and 95.2%, respectively; specificities were 97.6 and 98.1%, respectively. The intra-assay coefficient of variation (CV) ranged from 4.3 to 10.9% for anti-Ro/SSA and from 2.8 to 12.5% for anti-La/SSB; interassay CVs ranged from 6.5 to 13.2% and from 8.2 to 14.5%, respectively. Among the anti-Ro/SSA-positive samples, Ro60 was recognized by 66% of the test sera and Ro52 was recognized by 95% of the test sera. Thirty-four percent of the Ro/SSA-positive sera were reactive only with the Ro52 antigen, indicating that anti-Ro52 is the most common antibody specificity recognized by anti-Ro/SSA autoantibodies. No differences were found between the prevalences of anti-Ro60 and anti-Ro52 in relation to systemic lupus erythematosus or Sjögren's syndrome. The results of the present study indicate that this new immunoassay is an efficient diagnostic tool for the detection of anti-Ro/SSA and anti-La/SSB antibodies in patients with autoimmune disorders. PMID:11527804

  12. ALMA deep field in SSA22: Blindly detected CO emitters and [C II] emitter candidates

    NASA Astrophysics Data System (ADS)

    Hayatsu, Natsuki H.; Matsuda, Yuichi; Umehata, Hideki; Yoshida, Naoki; Smail, Ian; Swinbank, A. Mark; Ivison, Rob; Kohno, Kotaro; Tamura, Yoichi; Kubo, Mariko; Iono, Daisuke; Hatsukade, Bunyo; Nakanishi, Kouichiro; Kawabe, Ryohei; Nagao, Tohru; Inoue, Akio K.; Takeuchi, Tsutomu T.; Lee, Minju; Ao, Yiping; Fujimoto, Seiji; Izumi, Takuma; Yamaguchi, Yuki; Ikarashi, Soh; Yamada, Toru

    2017-06-01

    We report the identification of four millimeter line-emitting galaxies with the Atacama Large Milli/submillimeter Array (ALMA) in SSA22 Field (ADF22). We analyze the ALMA 1.1-mm survey data, with an effective survey area of 5 arcmin2, frequency ranges of 253.1-256.8 and 269.1-272.8 GHz, angular resolution of 0{^''.}7 and rms noise of 0.8 mJy beam-1 at 36 km s-1 velocity resolution. We detect four line-emitter candidates with significance levels above 6σ. We identify one of the four sources as a CO(9-8) emitter at z = 3.1 in a member of the proto-cluster known in this field. Another line emitter with an optical counterpart is likely a CO(4-3) emitter at z = 0.7. The other two sources without any millimeter continuum or optical/near-infrared counterpart are likely to be [C II] emitter candidates at z = 6.0 and 6.5. The equivalent widths of the [C II] candidates are consistent with those of confirmed high-redshift [C II] emitters and candidates, and are a factor of 10 times larger than that of the CO(9-8) emitter detected in this search. The [C II] luminosity of the candidates are 4-7 × 108 L⊙. The star formation rates (SFRs) of these sources are estimated to be 10-20 M⊙ yr-1 if we adopt an empirical [C II] luminosity-SFR relation. One of them has a relatively low S/N ratio, but shows features characteristic of emission lines. Assuming that at least one of the two candidates is a [C II] emitter, we derive a lower limit of [C II]-based star formation rate density (SFRD) at z ∼ 6. The resulting value of >10-2 M⊙ yr-1 Mpc-3 is consistent with the dust-uncorrected UV-based SFRD. Future millimeter/submillimeter surveys can be used to detect a number of high-redshift line emitters, with which to study the star formation history in the early universe.

  13. Remodeling pharmaceutical care in Sub-Saharan Africa (SSA) amidst human resources challenges and the HIV/AIDS pandemic.

    PubMed

    King, Rosalyn C; Fomundam, Henry N

    2010-01-01

    Pharmaceutical care, meant to complement a proper drug supply system, is a key component of a robust health care system and is the direct, responsible provision of medication-related care designed to achieve definite outcomes that improve a patient's quality of life. Beyond simply dispensing medicine, pharmaceutical care promotes adherence to therapeutic regimens and addresses problems such as overdosage, sub-therapeutic dosage, adverse drug reactions, medication errors, and untreated indications. The dearth of health care workers trained in pharmaceutical care coupled with inadequate access to medications creates multiple disease management challenges in Sub-Saharan Africa (SSA), which has 25% of the world's disease burden but only 1.3% of the world's health workforce. To prevent and treat HIV/AIDS, TB, malaria, and other maladies, the need is urgent to train and integrate the contributions of current workers who handle medications for major and minor health problems, especially those in licensed pharmacies and drug shops. On the aggregate in SSA, pharmaceutical care is in a nascent stage in most countries but needs to grow as a discipline as well as be tailored to specific country needs. The SSA solution lies in establishing health care system components where cadres of workers engage in pharmaceutical care practices, as well as store and distribute medications. Curriculum changes in pre-service education, more continuing education for the health workforce in place, and training pharmacists to supervise a lower cadre of assistants and others are among the elements in a pharmaceutical care paradigm shift which is the focus of this article. Copyright (c) 2009 John Wiley & Sons, Ltd.

  14. Heart sounds at home: feasibility of an ambulatory fetal heart rhythm surveillance program for anti-SSA-positive pregnancies.

    PubMed

    Cuneo, B F; Moon-Grady, A J; Sonesson, S-E; Levasseur, S; Hornberger, L; Donofrio, M T; Krishnan, A; Szwast, A; Howley, L; Benson, D W; Jaeggi, E

    2017-03-01

    Fetuses exposed to anti-SSA (Sjögren's) antibodies are at risk of developing irreversible complete atrioventricular block (CAVB), resulting in death or permanent cardiac pacing. Anti-inflammatory treatment during the transition period from normal heart rhythm (fetal heart rhythm (FHR)) to CAVB (emergent CAVB) can restore sinus rhythm, but detection of emergent CAVB is challenging, because it can develop in ⩽24 h. We tested the feasibility of a new technique that relies on home FHR monitoring by the mother, to surveil for emergent CAVB. We recruited anti-SSA-positive mothers at 16 to 18 weeks gestation (baseline) from 8 centers and instructed them to monitor FHR two times a day until 26 weeks, using a Doppler device at home. FHR was also surveilled by weekly or every other week fetal echo. If FHR was irregular, the mother underwent additional fetal echo. We compared maternal stress/anxiety before and after monitoring. Postnatally, infants underwent a 12-lead electrocardiogram. Among 133 recruited, 125 (94%) enrolled. Among those enrolled, 96% completed the study. Reasons for withdrawal (n=5) were as follows: termination of pregnancy, monitoring too time consuming or moved away. During home monitoring, 9 (7.5%) mothers detected irregular FHR diagnosed by fetal echo as normal (false positive, n=2) or benign atrial arrhythmia (n=7). No CAVB was undetected or developed after monitoring. Questionnaire analysis indicated mothers felt comforted by the experience and would monitor again in future pregnancies. These data suggest ambulatory FHR surveillance of anti-SSA-positive pregnancies is feasible, has a low false positive rate and is empowering to mothers.

  15. Crop selection for advanced life support systems in the ESA MELiSSA program: Durum wheat (Triticum turgidum var durum)

    NASA Astrophysics Data System (ADS)

    Stasiak, M.; Gidzinski, D.; Jordan, M.; Dixon, M.

    2012-06-01

    As part of an ESA MELiSSA investigation into advanced life support (ALS) candidate crop cultivar selection and growth requirements, the University of Guelph's Controlled Environment Systems Research Facility (CESRF) conducted a case study on growth and development of four durum wheat cultivars (Triticum turgidum var durum) grown hydroponically under controlled conditions in a sealed environment. Cultivars tested were Canadian developed Avonlea, Commander, Eurostar and Strongfield. There were few fundamental differences in durum quality parameters between hydroponically and field grown wheat, however yields of Eurostar and Strongfield exceeded those of field trials by 41% and 87% respectively.

  16. Pregnancy outcome of 126 anti-SSA/Ro-positive patients during the past 24 years--a retrospective cohort study.

    PubMed

    Luo, Yan; Zhang, Lili; Fei, Yunyun; Li, Yiqun; Hao, Donglin; Liu, Yi; Zhao, Yan

    2015-10-01

    The aims of our study are to observe the pregnancy outcome of anti-Sjögren's syndrome-related antigen A (SSA)/Ro-positive women and to predict the risk factors for adverse pregnancy outcome and neonatal lupus erythematosus (NLE). Clinical data of 126 anti-SSA/Ro-positive patients with 140 pregnancies were evaluated retrospectively, and the newborns were followed up as a cohort in 3 months. χ (2) test or logistic regression was used to predict the risk factors of lupus flares during pregnancy, fetal loss, and NLE. Twenty-six out of 93 pregnancies with systemic lupus erythematosus (SLE) experienced flares during pregnancy. Active disease prior to conception was the independent risk factor for flares [P = 0.002, odds ratio (OR) = 10.41 (95 % confidence interval (CI) = 2.34∼46.26)]. Continuous use of steroids and hydroxychloroquine (HCQ) might help decrease the risk (P = 0.041 and 0.015, respectively). Eleven out of 140 pregnancies ended with fetal loss, and 9 out of 113 live births were diagnosed with NLE. The presence of anti-phospholipid syndrome (APS) was associated with fetal loss (P = 0.018, OR = 6.41 (95 % CI = 1.57-26.14)). The presence of anti-Sjögren's syndrome-related antigen B (SSB)/La antibodies tended to increase the risk of giving birth to an infant with NLE (P = 0.140); on the other hand, duration of disease, history of renal involvement, and active SLE during pregnancy did not contribute to the incidence of NLE (P = 0.649, 0.685, and 1.000, respectively). Active disease without regular follow-up before conception significantly increased the risk of lupus flares during pregnancy. The continuous use of low-dose steroids and hydroxychloroquine might help maintain lower SLE activity. Concurrent APS instead of high titer of anti-SSA/Ro might raise the risk of fetal loss in anti-SSA/Ro-positive patients.

  17. The SSB-positive/SSA-negative antibody profile is not associated with key phenotypic features of Sjögren's syndrome.

    PubMed

    Baer, Alan N; McAdams DeMarco, Mara; Shiboski, Stephen C; Lam, Mi Y; Challacombe, Stephen; Daniels, Troy E; Dong, Yi; Greenspan, John S; Kirkham, Bruce W; Lanfranchi, Hector E; Schiødt, Morten; Srinivasan, Muthiah; Umehara, Hisanori; Vivino, Frederick B; Vollenweider, Cristina F; Zhao, Yan; Criswell, Lindsey A; Shiboski, Caroline H

    2015-08-01

    To determine whether the Sjögren's syndrome B (SSB)-positive/Sjögren's syndrome A (SSA)-negative antibody profile is associated with key phenotypic features of SS. Among registrants in the Sjögren's International Collaborative Clinical Alliance (SICCA) with possible or established SS, we compared anti-SSA/anti-SSB reactivity profiles against concurrent phenotypic features. We fitted logistic regression models to explore the association between anti-SSA/anti-SSB reactivity profile and each key SS phenotypic feature, controlling for potential confounders. Among 3297 participants, 2061 (63%) had negative anti-SSA/anti-SSB, 1162 (35%) had anti-SSA with or without anti-SSB, and 74 (2%) anti-SSB alone. Key SS phenotypic features were more prevalent and had measures indicative of greater disease activity in those participants with anti-SSA, either alone or with anti-SSB, than in those with anti-SSB alone or negative SSA/SSB serology. These between-group differences were highly significant and not explained by confounding by age, race/ethnicity or gender. Participants with anti-SSB alone were comparable to those with negative SSA/SSB serology in their association with these key phenotypic features. Among SICCA participants classified with SS on the basis of the American-European Consensus Group or American College of Rheumatology criteria, only 2% required the anti-SSB-alone test result to meet these criteria. The presence of anti-SSB, without anti-SSA antibodies, had no significant association with SS phenotypic features, relative to seronegative participants. The solitary presence of anti-SSB antibodies does not provide any more support than negative serology for the diagnosis of SS. This serological profile should thus be interpreted cautiously in clinical practice and potentially eliminated from future classification criteria. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  18. Anti-SSA/SSB-negative Sjögren's syndrome shows a lower prevalence of lymphoproliferative manifestations, and a lower risk of lymphoma evolution.

    PubMed

    Quartuccio, Luca; Baldini, Chiara; Bartoloni, Elena; Priori, Roberta; Carubbi, Francesco; Corazza, Laura; Alunno, Alessia; Colafrancesco, Serena; Luciano, Nicoletta; Giacomelli, Roberto; Gerli, Roberto; Valesini, Guido; Bombardieri, Stefano; De Vita, Salvatore

    2015-11-01

    This study aims to compare clinical and laboratory features of patients who, while satisfying the American European Consensus Group (AECG) criteria for primary Sjögren's syndrome (SS), do not present the positivity for anti-Ro/SSA and/or anti-La/SSB, with patients that meet the AECG criteria and are positive for anti-Ro/SSA and/or anti-La/SSB. 548 patients were selected based on the following criteria, and exclusion of patients negative for histopathology but positive for anti-Ro/SSA and anti-La/SSB: 1. Fulfilment of the AECG criteria, 2. Performance of minor salivary gland biopsy, 3. Search for anti-Ro/SSA and anti-La/SSB, 4. Absence of hepatitis C virus infection. Univariate and multivariate analyses were performed. Two groups were compared: 342 patients were positive for both the histopathology and for anti-Ro/SSA and/or anti-La/SSB (H-only) and 206 patients were positive for histopathology, but negative for autoantibodies (H+SSA/SSB). The following variables were statistically found to be associated with H+SSA/SSB: younger age at diagnosis (p<0.0001), glandular swelling (p=0.01), purpura (p=0.04), leucopoenia (p=0.0001), lymphoma (p=0.002), low C3 (p=0.04), low C4 (p=0.01), hypergammaglobulinemia (p<0.0001), ANA (p<0.0001), rheumatoid factor (p<0.0001), and serum cryoglobulins (p=0.039). ANA positivity (OR 6.9), hypergammaglobulinemia (OR 5.1), positive rheumatoid factor (OR 2.3), and age at diagnosis (OR 0.97) were also selected by multivariate analyses as associated with H+SSA/SSB. Primary SS negative for anti-Ro/SSA and anti-La/SSB antibodies appears to be characterized by a lower risk of lymphoma and by a lower level of B-cell expansion. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Integration of a Higher Plant Chamber into the European Space Agency's MELiSSA Pilot Plant: The Canadian Role in Advanced Life Support Test-Bed Development

    NASA Astrophysics Data System (ADS)

    Waters, Geoffrey; Lawson, Jamie; Gidzinski, Danuta; Stasiak, Michael; Dixon, Mike; Peiro, Enrique; Godia, Francesc; Paille, Christel; Fossen, Arnaud; Lamaze, Brigitte; Lasseur, Christophe

    The European Space Agency's Micro-Ecological Life Support System Alternative (MELiSSA) project has been conceived as a tool for developing the technology of future biological life support systems required for long-term human space exploration missions to the Moon or Mars. The main life support functions of MELiSSA are the recycling of waste (inedible plant biomass, human excrement), carbon dioxide and minerals and the production of food, fresh water and air revitalization. Based on the principle of an aquatic ecosystem, MELiSSA is comprised of four microbial compartments and a higher plant compartment integrated in a closed loop. Each compartment is studied, designed and demonstrated at laboratory scale before being scaled-up for subsequent integration into the MELISSA Pilot Plant (MPP) at the Universitat Aut`noma de Barcelona. Work related to higher plant cultivation systems, o which have been historically focussed at the University of Guelph's Controlled Environment Systems Research Facility (CESRF), has included design of the HPC for the MPP, the metabolic characterization of MELiSSA candidate crops and the validation of theoretical gas exchange and nutrient dynamic models, The presented paper will review some of the recent data and HPC design work of CESRF conducted as part of Canada's involvement in the MELiSSA program and its partnership in the development of the MPP terrestrial demonstration test-bed.

  20. Production characteristics of lettuce Lactuca sativa L. in the frame of the first crop tests in the Higher Plant Chamber integrated into the MELiSSA Pilot Plant

    NASA Astrophysics Data System (ADS)

    Tikhomirova, Natalia; Lawson, Jamie; Stasiak, Michael; Dixon, Mike; Paille, Christel; Peiro, Enrique; Fossen, Arnaud; Godia, Francesc

    Micro-Ecological Life Support System Alternative (MELiSSA) is an artificial closed ecosystem that is considered a tool for the development of a bioregenerative life support system for manned space missions. One of the five compartments of MELiSSA loop -Higher Plant Chamber was recently integrated into the MELiSSA Pilot Plant facility at Universitat Aut`noma deo Barcelona. The main contributions expected by integration of this photosynthetic compartment are oxygen, water, vegetable food production and CO2 consumption. Production characteristics of Lactuca sativa L., as a MELiSSA candidate crop, were investigated in this work in the first crop experiments in the MELiSSA Pilot Plant facility. The plants were grown in batch culture and totaled 100 plants with a growing area 5 m long and 1 m wide in a sealed controlled environment. Several replicates of the experiments were carried out with varying duration. It was shown that after 46 days of lettuce cultivation dry edible biomass averaged 27, 2 g per plant. However accumulation of oxygen in the chamber, which required purging of the chamber, and decrease in the food value of the plants was observed. Reducing the duration of the tests allowed uninterrupted test without opening the system and also allowed estimation of the crop's carbon balance. Results of productivity, tissue composition, nutrient uptake and canopy photosynthesis of lettuce regardless of test duration are discussed in the paper.

  1. Atomic arias

    NASA Astrophysics Data System (ADS)

    Crease, Robert P.

    2009-01-01

    The American composer John Adams uses opera to dramatize controversial current events. His 1987 work Nixon in China was about the landmark meeting in 1972 between US President Richard Nixon and Chairman Mao Zedong of China; The Death of Klinghoffer (1991) was a musical re-enactment of an incident in 1985 when Palestinian terrorists kidnapped and murdered a wheelchair-bound Jewish tourist on a cruise ship. Adams's latest opera, Doctor Atomic, is also tied to a controversial event: the first atomic-bomb test in Alamogordo, New Mexico, on 16 June 1945. The opera premièred in San Francisco in 2005, had a highly publicized debut at the Metropolitan Opera in New York in 2008, and will have another debut on 25 February - with essentially the same cast - at the English National Opera in London.

  2. Atomic rivals

    SciTech Connect

    Goldschmidt, B.

    1990-01-01

    This book is a memoir of rivalries among the Allies over the bomb, by a participant and observer. Nuclear proliferation began in the uneasy wartime collaboration of the United States, England, Canada, and Free France to produce the atom bomb. Through the changes of history, a young French chemist had a role in almost every act of this international drama. This memoir is based on Goldschmidt's own recollections, interviews with other leading figures, and 3,000 pages of newly declassified documents in Allied archives. From his own start as Marie Curie's lab assistant, Goldschmidt's career was closely intertwined with Frances complicated rise to membership in the nuclear club. As a refugee from the Nazis, he became part of the wartime nuclear energy project in Canada and found himself the only French scientist to work (although briefly) on the American atom bomb project.

  3. Corner Office: Google's Dan Clancy

    ERIC Educational Resources Information Center

    Albanese, Andrew Richard; Oder, Norman

    2009-01-01

    This article presents an interview with Dan Clancy, engineering director for Google Book Search. In this interview, Clancy talks about the pending Google Book Search settlement, involving millions of volumes digitized from libraries, which drew a lawsuit from the Association of American Publishers and the Authors Guild. He also discusses pricing,…

  4. Corner Office: Google's Dan Clancy

    ERIC Educational Resources Information Center

    Albanese, Andrew Richard; Oder, Norman

    2009-01-01

    This article presents an interview with Dan Clancy, engineering director for Google Book Search. In this interview, Clancy talks about the pending Google Book Search settlement, involving millions of volumes digitized from libraries, which drew a lawsuit from the Association of American Publishers and the Authors Guild. He also discusses pricing,…

  5. Atomic physics

    SciTech Connect

    Livingston, A.E.; Kukla, K.; Cheng, S.

    1995-08-01

    In a collaboration with the Atomic Physics group at Argonne and the University of Toledo, the Atomic Physics group at the University of Notre Dame is measuring the fine structure transition energies in highly-charged lithium-like and helium-like ions using beam-foil spectroscopy. Precise measurements of 2s-2p transition energies in simple (few-electron) atomic systems provide stringent tests of several classes of current atomic- structure calculations. Analyses of measurements in helium-like Ar{sup 16+} have been completed, and the results submitted for publication. A current goal is to measure the 1s2s{sup 3}S{sub 1} - 1s2p{sup 3}P{sub 0} transition wavelength in helium-like Ni{sup 26+}. Measurements of the 1s2s{sup 2}S{sub 1/2} - 1s2p{sup 2}P{sub 1/2,3/2} transition wavelengths in lithium-like Kr{sup 33+} is planned. Wavelength and lifetime measurements in copper-like U{sup 63+} are also expected to be initiated. The group is also participating in measurements of forbidden transitions in helium-like ions. A measurement of the lifetime of the 1s2s{sup 3}S{sub 1} state in Kr{sup 34+} was published recently. In a collaboration including P. Mokler of GSI, Darmstadt, measurements have been made of the spectral distribution of the 2E1 decay continuum in helium-like Kr{sup 34+}. Initial results have been reported and further measurements are planned.

  6. Atomic Databases

    NASA Astrophysics Data System (ADS)

    Mendoza, Claudio

    2000-10-01

    Atomic and molecular data are required in a variety of fields ranging from the traditional astronomy, atmospherics and fusion research to fast growing technologies such as lasers, lighting, low-temperature plasmas, plasma assisted etching and radiotherapy. In this context, there are some research groups, both theoretical and experimental, scattered round the world that attend to most of this data demand, but the implementation of atomic databases has grown independently out of sheer necessity. In some cases the latter has been associated with the data production process or with data centers involved in data collection and evaluation; but sometimes it has been the result of individual initiatives that have been quite successful. In any case, the development and maintenance of atomic databases call for a number of skills and an entrepreneurial spirit that are not usually associated with most physics researchers. In the present report we present some of the highlights in this area in the past five years and discuss what we think are some of the main issues that have to be addressed.

  7. BOREAS HYP-8 DEM Data Over The NSA-MSA and SSA-MSA in The AEAC Projection

    NASA Technical Reports Server (NTRS)

    Knapp, David E.; Hall, Forrest G. (Editor); Wang, Xue-Wen; Band, L. E.; Smith, David E. (Technical Monitor)

    2000-01-01

    These data were derived from the original Digital Elevation Models (DEMs) produced by the Boreal Ecosystem-Atmosphere Study (BOREAS) Hydrology (HYD)-8 team. The original DEMs were in the Universal Transverse Mercator (UTM) projection, while this product is projected in the Albers Equal-Area Conic (AEAC) projection. The pixel size of the data is 100 meters, which is appropriate for the 1:50,000-scale contours from which the DEMs were made. The original data were compiled from information available in the 1970s and 1980s. This data set covers the two Modeling Sub-Areas (MSAs) that are contained within the Southern Study Area (SSA) and the Northern Study Area (NSA). The data are stored in binary, image format files. The DEM data over the NSA-MSA and SSA-MSA in the AEAC projection are available from the Earth Observing System Data and Information System (EOSDIS) Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC). The data files are available on a CD-ROM (see document number 20010000884).

  8. Induction of Osmoadaptive Mechanisms and Modulation of Cellular Physiology Help Bacillus licheniformis Strain SSA 61 Adapt to Salt Stress

    SciTech Connect

    Paul, Sangeeta; Aggarwal, Chetana; Thakur, Jyoti Kumar; Bandeppa, G.S.; Khan, Md. Aslam; Pearson, Lauren M.; Babnigg, Gyorgy; Giometti, Carol S.; Joachimiak, Andrzej

    2015-01-06

    Bacillus licheniformis strain SSA 61, originally isolated from Sambhar salt lake, was observed to grow even in the presence of 25 % salt stress. Osmoadaptive mechanisms of this halotolerant B. licheniformis strain SSA 61, for long-term survival and growth under salt stress, were determined. Proline was the preferentially accumulated compatible osmolyte. There was also increased accumulation of antioxidants ascorbic acid and glutathione. Among the different antioxidative enzymes assayed, superoxide dismutase played the most crucial role in defense against salt-induced stress in the organism. Adaptation to stress by the organism involved modulation of cellular physiology at various levels. There was enhanced expression of known proteins playing essential roles in stress adaptation, such as chaperones DnaK and GroEL, and general stress protein YfkM and polynucleotide phosphorylase/polyadenylase. Proteins involved in amino acid biosynthetic pathway, ribosome structure, and peptide elongation were also overexpressed. Salt stress-induced modulation of expression of enzymes involved in carbon metabolism was observed. There was up-regulation of a number of enzymes involved in generation of NADH and NADPH, indicating increased cellular demand for both energy and reducing power.

  9. Induction of osmoadaptive mechanisms and modulation of cellular physiology help Bacillus licheniformis strain SSA 61 adapt to salt stress.

    PubMed

    Paul, Sangeeta; Aggarwal, Chetana; Thakur, Jyoti Kumar; Bandeppa, G S; Khan, Md Aslam; Pearson, Lauren M; Babnigg, Gyorgy; Giometti, Carol S; Joachimiak, Andrzej

    2015-04-01

    Bacillus licheniformis strain SSA 61, originally isolated from Sambhar salt lake, was observed to grow even in the presence of 25 % salt stress. Osmoadaptive mechanisms of this halotolerant B. licheniformis strain SSA 61, for long-term survival and growth under salt stress, were determined. Proline was the preferentially accumulated compatible osmolyte. There was also increased accumulation of antioxidants ascorbic acid and glutathione. Among the different antioxidative enzymes assayed, superoxide dismutase played the most crucial role in defense against salt-induced stress in the organism. Adaptation to stress by the organism involved modulation of cellular physiology at various levels. There was enhanced expression of known proteins playing essential roles in stress adaptation, such as chaperones DnaK and GroEL, and general stress protein YfkM and polynucleotide phosphorylase/polyadenylase. Proteins involved in amino acid biosynthetic pathway, ribosome structure, and peptide elongation were also overexpressed. Salt stress-induced modulation of expression of enzymes involved in carbon metabolism was observed. There was up-regulation of a number of enzymes involved in generation of NADH and NADPH, indicating increased cellular demand for both energy and reducing power.

  10. Development and application of dual-fluorescence reporter systems for measuring specific nuclease activity based on SSA repair mechanism.

    PubMed

    Furong, Han; Ling, Wang; Kun, Xu; Zhiying, Zhang; Xin, Wang

    2015-10-01

    Reporter vector system has become an important method for measuring activity of specific nucleases because of its fast construction, simple modification, easy operation, economic effectiveness as well as its role in enriching positive cells with genomic modification through mediating screen of specific nucleases positive cells. After introducing double strand breaks (DSBs), a reporter system based on non-homologous end joining (NHEJ)-mediated repair can only repair maximally two thirds of reporter genes after optimization, while single strand annealing (SSA)-mediated repair can repair all reporter genes theoretically which has higher sensitivity and facilitates the detection of specific nuclease with low activity and provides an effective way to detect specific nuclease activity in genome modification studies. In this study, we designed and constructed three sets of dual-fluorescence reporter systems based on SSA repair mechanism and applied the mRFP-eGFP system in measuring the effective activity of three pairs of ZFNs, which was 8.9%, 9.3% and 5.0%, respectively. Our study provides an effective way to detect the activity of nucleases.

  11. Anti-Ro/SSA autoantibody-positive women's experience of information given on the risk of congenital heart block.

    PubMed

    Tingström, J; Hjelmstedt, A; Welin Henriksson, E; Ambrosi, A; Sonesson, S-E; Wahren-Herlenius, M

    2016-04-01

    Congenital heart block (CHB) may develop in fetuses of women with anti-Ro/SSA autoantibodies, and carries substantial morbidity and mortality. The aim was to evaluate how information on CHB is imparted and identify areas of improvement. A questionnaire was distributed to anti-Ro/SSA antibody-positive women who had either participated in a surveillance programme but whose expected child did not develop CHB (n = 100, denoted Doppler-Assessed Pregnancies (DAP) group) or given birth to a child with CHB (n = 88, denoted CHB-Affected Pregnancies (CAP) group). The response rate was 83% (157/188). Most women received the information on CHB when they were already pregnant (DAP group 60%, CAP group 83%). However, a majority of them would have wanted the information before pregnancy (DAP group 52%, CAP group 56%), and most stated that it would not have influenced their decision to have a child (DAP group 77%, CAP group 58%). The ability to both understand the information and to perceive the information as sufficient were significantly higher when someone trained in paediatric cardiology gave the information. Our findings indicate that information on CHB should be given to women before pregnancy. The data further highlight the importance of having specific knowledge for giving relevant and understandable, yet sufficient information. © The Author(s) 2015.

  12. Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins.

    PubMed

    Kim, S; Schilke, B; Craig, E A; Horwich, A L

    1998-10-27

    The nature of chaperone action in the eukaryotic cytosol that assists newly translated cytosolic proteins to reach the native state has remained poorly defined. Actin, tubulin, and Galpha transducin are assisted by the cytosolic chaperonin, CCT, but many other proteins, for example, ornithine transcarbamoylase (OTC), a cytosolic homotrimeric enzyme of yeast, do not require CCT action. Here, we observe that yeast cytosolic OTC is assisted to its native state by the SSA class of yeast cytosolic Hsp70 proteins. In vitro, refolding of OTC diluted from denaturant was assisted by crude yeast cytosol and ATP and found to be directed by SSA1/2. In vivo, when OTC was induced in a temperature-sensitive SSA-deficient strain, it exhibited reduced specific activity, and nonnative subunits were detected in the soluble fraction. These findings indicate that, in vivo, the Hsp70 system assists in folding at least some newly translated cytosolic enzymes, most likely functioning in a posttranslational manner.

  13. Folding in vivo of a newly translated yeast cytosolic enzyme is mediated by the SSA class of cytosolic yeast Hsp70 proteins

    PubMed Central

    Kim, Suwon; Schilke, Brenda; Craig, Elizabeth A.; Horwich, Arthur L.

    1998-01-01

    The nature of chaperone action in the eukaryotic cytosol that assists newly translated cytosolic proteins to reach the native state has remained poorly defined. Actin, tubulin, and Gα transducin are assisted by the cytosolic chaperonin, CCT, but many other proteins, for example, ornithine transcarbamoylase (OTC), a cytosolic homotrimeric enzyme of yeast, do not require CCT action. Here, we observe that yeast cytosolic OTC is assisted to its native state by the SSA class of yeast cytosolic Hsp70 proteins. In vitro, refolding of OTC diluted from denaturant was assisted by crude yeast cytosol and ATP and found to be directed by SSA1/2. In vivo, when OTC was induced in a temperature-sensitive SSA-deficient strain, it exhibited reduced specific activity, and nonnative subunits were detected in the soluble fraction. These findings indicate that, in vivo, the Hsp70 system assists in folding at least some newly translated cytosolic enzymes, most likely functioning in a posttranslational manner. PMID:9789005

  14. Environment-Level Strategies to Support Independent Control of Finances: A Response to the SSA Review of Financial Capability Determination Review.

    PubMed

    Harper, Annie; Rowe, Michael

    2017-01-01

    The Social Security Administration (SSA) recently completed an evaluation of the process by which representative payees are assigned. The SSA report is welcome, particularly for its focus on developing more accurate, real-world assessments of a person's financial capability and its recognition of the need for more flexible options for people with disabilities. Crucially, the report discusses the impact of the broader environment-specifically, conditions related to living in poverty. However, it provides no guidance about environmental interventions that could enable more beneficiaries to manage their funds without a payee. Innovative financial products could be offered to beneficiaries, and the retail industry could develop processes to support responsible financial management by people with mental illness. Changes to SSA benefits systems, including raising benefits levels and asset limits, could enable more beneficiaries to manage their funds independently.

  15. [Severe fever with thrombocytopenia syndrome virus nucleoprotein specifically binds to 60kD SSA/Ro protein in host cells].

    PubMed

    Zheng, Bin; Wang, Tao; Zhang, Shuo; Li, A-Qian; Li, Chuan; Zhang, Quan-Fu; Liang, Mi-Fang; Li, De-Xin

    2014-05-01

    This study aims to investigate whether the nucleoprotein (NP) of severe fever with thrombocytopenia syndrome virus (SFTSV) can impact the cellular immunity of host cells. Gene segments that encode the NP and non-structural protein (NSs) of SFTSV were inserted into eukaryotic expression vector VR1012. Host proteins that interact with NP and affect immunity were identified with co-immunoprecipitation (IP), SDS-PAGE, mass spectrometry (MS), and Western blot. Co-localization of NP and the identified host proteins was confirmed by confocal microscopy. A 60kD SSA/Ro, a protein related to immunity, interacted with NP, as found by IP and MS. Confocal microscopy showed that NP and SSA/Ro were co-localized in cytoplasm. These results indicated that SFTSV NP may specifically bind to 60kD SSA/Ro and cause a series of immune responses and clinical symptoms.

  16. RETRACTED: Blockade of TNF-α signaling suppresses the AREG-mediated IL-6 and IL-8 cytokines secretion induced by anti-Ro/SSA autoantibodies.

    PubMed

    Sisto, Margherita; Lisi, Sabrina; Lofrumento, Dario Domenico; Cucci, Liana; Mitolo, Vincenzo; D'Amore, Massimo

    2010-09-20

    The aim of this study was to analyze the Furin-TNF-α-converting enzyme (TACE)-amphiregulin (AREG)-IL-6/IL-8 secretion pathway in non-neoplastic human salivary gland epithelial cells (SGECs) stimulated with anti-Ro/SSA autoantibodies (Abs). We examined whether anti-Ro/SSA Abs-mediated TACE activation is responsible for AREG activation. As recent studies have demonstrated that AREG could induce proinflammatory cytokines secretion in epithelial cells, we discuss how TACE-mediated AREG shedding, caused by anti-Ro/SSA Abs treatment, could have a critical role in TNF-α-induced IL-6 and IL-8 secretion by SGEC. Furthermore, the effects of TNF-α blockade on AREG expression and TNF-α-AREG-mediated IL-6 and IL-8 secretion were evaluated. We have discovered that the upregulation of AREG occurs through TNF-α produced after anti-Ro/SSA Abs uptake via Fcγ receptors. Biological drug adalimumab and the gene silencing technique were used to study the AREG-IL-6/IL-8 secretion pathway, demonstrating that (i) adalimumab-mediated TNF-α blocking and TNF-α gene silencing provoke a significant decrease of proinflammatory cytokines production and AREG expression in anti-Ro/SSA Abs-treated SGEC; (ii) AREG gene silencing has a potent inhibitory effect on TNF-α-induced IL-6 and IL-8 secretion in SGEC treated with anti-Ro/SSA Abs; (iii) an inspection of the kinetics of cytokine production after exogeni TNF-α and AREG addition, and the use of cycloheximide in the presence of exogenous TNF-α as stimulant, clarified that TNF-α induces IL-6 and IL-8 secretion through AREG.Laboratory Investigation advance online publication, 20 September 2010; doi:10.1038/labinvest.2010.168.

  17. Clinical associations of anti-SSA/Ro60 and anti-Ro52/TRIM21 antibodies: Diagnostic utility of their separate detection.

    PubMed

    Menéndez, Aurora; Gómez, Jesús; Escanlar, Esther; Caminal-Montero, Luis; Mozo, Lourdes

    2013-02-01

    Clinical associations of anti-SSA/Ro60 and anti-Ro52/TRIM21 antibodies are not yet fully established. In order to analyse the diagnostic utility of their separate detection, we retrospectively revised the clinical data of 200 anti-SSA/Ro60 and/or anti-Ro52/TRIM21 positive patients identified by line immunoassay during ANA routine detection. Anti-SSA/Ro60 positive patients showed a significantly higher prevalence of autoimmune diseases (AIDs) independently on the presence of anti-Ro52/TRIM21 (OR 3.13, 95% CI 1.10-8.88, p = 0.032). Anti-SSA/Ro60 was independently associated with systemic lupus erythematosus (SLE) when comparing with Sjögren's syndrome (SS) and other systemic AIDs (OR 3.46, 95% CI 1.08-11.06, p = 0.036). The more frequent specificity found in cutaneous lupus erythematosus (CLE) was also anti-SSA/Ro60. In contrast, detection of isolated anti-Ro52/TRIM21 was characteristic of SS (7/35, 20.0%), diffuse cutaneous systemic sclerosis (dcSSc) (3/4, 75.0%), primary biliary cirrhosis (PBC) (4/5, 80.0%) and, specially, of polymyositis/dermatomyositis (PM/DM) (6/6, 100%). In fact, anti-Ro52/TRIM21 was the only antibody detected in 4 out of the 6 PM/DM patients. Malignancies mainly account for the observed high prevalence of mono-specific anti-Ro52/TRIM21 in patients with non-AIDs (10/15, 62.5%). In conclusion, this retrospective study supports the routine distinction of anti-SSA/Ro60 and anti-Ro52/TRIM21 due to their different clinical associations.

  18. A serology-based approach combined with clinical examination of 125 Ro/SSA-positive patients to define incidence and prevalence of subacute cutaneous lupus erythematosus.

    PubMed

    Popovic, Karin; Nyberg, Fredrik; Wahren-Herlenius, Marie; Nyberg, Filippa

    2007-01-01

    To estimate the incidence and prevalence of Ro/SSA-positive subacute cutaneous lupus erythematosus (SCLE) in Stockholm County, Sweden (1.8 million inhabitants) and to investigate the frequency of photosensitivity and other clinical manifestations associated with Ro/SSA autoantibodies. Ro/SSA-positive patients in Stockholm were identified via registry-based searches. All patients who tested positive for the presence of Ro/SSA autoantibodies during 1996-2002 (n = 1,323; 85% women) were identified. A questionnaire was sent to all patients still living in Stockholm in 2003 (n = 1,048). Patients who reported having skin symptoms and photosensitivity (n = 125) underwent a clinical examination. Of the 741 (71%) of 1,048 Ro/SSA-positive patients who responded to the questionnaire, 400 (54%) reported having photosensitivity, and of these patients, 125 agreed to be clinically examined. A diagnosis of LE was confirmed in 59 of the 125 patients (SCLE in 20, systemic LE [SLE] in 33, and chronic CLE in 6). Eighty-six patients reported experiencing symptoms consistent with polymorphous light eruption (PLE). Comorbidities such as cardiovascular disease, autoimmune disease, and other skin diseases were common. The incidence of Ro/SSA-positive SCLE during the study period was estimated to be 0.7 cases per 100,000 persons per year and the prevalence was approximately 6.2-14 in 100,000 persons. The incidence of Ro/SSA-positive SCLE in Stockholm County, Sweden is estimated to be 0.7 per 100,000 persons per year as compared with an incidence of SLE in Sweden of 4.8 per 100,000 persons per year. The prevalence is estimated to be 6.2-14 in 100,000 persons. Self-reported photosensitivity commonly corresponds to a history of PLE in Ro/SSA-positive patients, even when the clinical profile of SCLE is absent. Photoprotection should therefore be included in the treatment recommendations for these patients.

  19. Atom Skimmers and Atom Lasers Utilizing Them

    NASA Technical Reports Server (NTRS)

    Hulet, Randall; Tollett, Jeff; Franke, Kurt; Moss, Steve; Sackett, Charles; Gerton, Jordan; Ghaffari, Bita; McAlexander, W.; Strecker, K.; Homan, D.

    2005-01-01

    Atom skimmers are devices that act as low-pass velocity filters for atoms in thermal atomic beams. An atom skimmer operating in conjunction with a suitable thermal atomic-beam source (e.g., an oven in which cesium is heated) can serve as a source of slow atoms for a magneto-optical trap or other apparatus in an atomic-physics experiment. Phenomena that are studied in such apparatuses include Bose-Einstein condensation of atomic gases, spectra of trapped atoms, and collisions of slowly moving atoms. An atom skimmer includes a curved, low-thermal-conduction tube that leads from the outlet of a thermal atomic-beam source to the inlet of a magneto-optical trap or other device in which the selected low-velocity atoms are to be used. Permanent rare-earth magnets are placed around the tube in a yoke of high-magnetic-permeability material to establish a quadrupole or octupole magnetic field leading from the source to the trap. The atoms are attracted to the locus of minimum magnetic-field intensity in the middle of the tube, and the gradient of the magnetic field provides centripetal force that guides the atoms around the curve along the axis of the tube. The threshold velocity for guiding is dictated by the gradient of the magnetic field and the radius of curvature of the tube. Atoms moving at lesser velocities are successfully guided; faster atoms strike the tube wall and are lost from the beam.

  20. An analysis of the potential for achieving the fourth millennium development goal in SSA with domestic resources.

    PubMed

    O'Hare, Bernadette; Makuta, Innocent

    2015-02-25

    The importance of good health is reflected in the fact that more than half of the eight Millennium Development Goals (MDGs) are aimed at improving health status. Goal 4 (MDG4) aims to reduce child mortality. The progress indicator for goal 4 is the under-five mortality rate (U5M), with a targeted reduction of two thirds by 2015 from 1990 levels. This paper seeks to compare the time (in years) Sub Saharan African (SSA) countries will take to reach their MDG4 target at the current rate of decline, and the time it could have taken to reach their target if domestic resources had not been lost through illicit financial flows, corruption and servicing of debt since 2000. We estimate the amount by which the Gross Domestic Product (GDP) per capita would increase (in percentage terms) if losses of resource through illicit financial flows, corruption and debt servicing, were reduced. Using the income elasticity of U5M, a metric which reports the percentage change in U5M for a one percent change in GDP per capita, we estimate the potential gains in the annual reduction of the under-five mortality if these resource losses were reduced. At the current rate of reduction in U5M, nine countries out of this sample of 36 SSA countries (25%) will achieve their MDG4 target by 2015. In the absence of the leakages (IFF, corruption and debt service) 30 out of 36 (83%) would reach their MDG4 target by 2015 and all except one country, Zimbabwe would have achieved their MDG4 by 2017 (97%). In view of the uncertainty of the legitimacy of African debts we have also provided results where we excluded debt repayment from our analysis. Most countries would have met MDG4 target by curtailing these outflows. In order to release latent resources in SSA for development, action will be needed both by African countries and internationally. We consider that stemming these outflows, and thereby reducing the need for aid, can be achieved with a more transparent global financial system.

  1. PASS Program. SSA Work Incentive for Disabled Beneficiaries Poorly Managed. Report to the Committee on Finance, U.S. Senate, and the Committee on Ways and Means, House of Representatives.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC. Health, Education, and Human Services Div.

    The General Accounting Office reviewed the Social Security Administration's (SSA) Plan for Achieving Self-Support (PASS) program, which was established in 1972 to help disability benefit recipients return to employment. The study evaluated the SSA's management of the PASS program, including the program's impact on employment, and sought to…

  2. Atomic memory

    NASA Astrophysics Data System (ADS)

    Brewer, R. G.; Hahn, E. L.

    1984-12-01

    The fundamental principles of atomic-memory effects related to the Loschmidt paradox in the second law of thermodynamics are introduced and illustrated with simple analogies, photographs, and diagrams; and the results of RF and laser experiments are summarized. Nuclear-spin echoes in response to RF pulses and the NMR free-induction decay phenomenon are described, and the extension of these concepts to the visible spectrum in laser-frequency-switching and multipulsed-laser experiments is examined with an emphasis on studies of free-induction decay in LaF3 crystals containing Pr impurities (DeVoe and Brewster). The laser-induced phenomena can be applied to studies of intramolecular and intermolecular interactions, and an improved understanding of the RF effects is needed to enhance the performance of medical NMR imaging systems.

  3. Atomic magnetometer

    DOEpatents

    Schwindt, Peter [Albuquerque, NM; Johnson, Cort N [Albuquerque, NM

    2012-07-03

    An atomic magnetometer is disclosed which uses a pump light beam at a D1 or D2 transition of an alkali metal vapor to magnetically polarize the vapor in a heated cell, and a probe light beam at a different D2 or D1 transition to sense the magnetic field via a polarization rotation of the probe light beam. The pump and probe light beams are both directed along substantially the same optical path through an optical waveplate and through the heated cell to an optical filter which blocks the pump light beam while transmitting the probe light beam to one or more photodetectors which generate electrical signals to sense the magnetic field. The optical waveplate functions as a quarter waveplate to circularly polarize the pump light beam, and as a half waveplate to maintain the probe light beam linearly polarized.

  4. BOREAS HYD-8 DEM Data Over the NSA-MSA and SSA-MSA in the UTM Projection

    NASA Technical Reports Server (NTRS)

    Wang, Xue-Wen; Hall, Forrest G. (Editor); Knapp, David E. (Editor); Band, L. E.; Smith, David E. (Technical Monitor)

    2000-01-01

    The BOREAS HYD-8 team focused on describing the scaling behavior of water and carbon flux processes at local and regional scales. These DEMs were produced from digitized contours at a cell resolution of 100 meters. Vector contours of the area were used as input to a software package that interpolates between contours to create a DEM representing the terrain surface. The vector contours had a contour interval of 25 feet. The data cover the BOREAS MSAs of the SSA and NSA and are given in a UTM map projection. Most of the elevation data from which the DEM was produced were collected in the 1970s or 1980s. The data are stored in binary, image format files. The data files are available on a CD-ROM (see document number 20010000884) or from the Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC).

  5. New collinear twist-3 analysis of transverse SSA: Toward a resolution for the sign-mismatch problem

    SciTech Connect

    Kanazawa, Koichi; Pitonyak, Daniel; Koike, Yuji; Metz, Andreas

    2014-10-19

    We present a new collinear twist-3 analysis of the transverse SSA AN at RHIC. We use the TMD Sivers/Collins function to fix some of the relevant collinear twist-3 functions and perform a fit of the RHIC data with other parameterized twist-3 functions. This allows us to keep the consistency among descriptions in pp collision, SIDIS, and e+e annihilation and thus could provide a unified description of the spin asymmetries in the low- and high-PT processes. In conclusion, by taking into account the twist-3 fragmentation contribution, we show for the first time this contribution could be the main source of AN in pp → hX and its inclusion could provide a solution for the sign-mismatch problem.

  6. New collinear twist-3 analysis of transverse SSA: Toward a resolution for the sign-mismatch problem

    DOE PAGES

    Kanazawa, Koichi; Pitonyak, Daniel; Koike, Yuji; ...

    2014-10-19

    We present a new collinear twist-3 analysis of the transverse SSA AN at RHIC. We use the TMD Sivers/Collins function to fix some of the relevant collinear twist-3 functions and perform a fit of the RHIC data with other parameterized twist-3 functions. This allows us to keep the consistency among descriptions in pp collision, SIDIS, and e+e– annihilation and thus could provide a unified description of the spin asymmetries in the low- and high-PT processes. In conclusion, by taking into account the twist-3 fragmentation contribution, we show for the first time this contribution could be the main source of ANmore » in pp↑ → hX and its inclusion could provide a solution for the sign-mismatch problem.« less

  7. Preliminary Modelling of Mass Flux at the Surface of Plant Leaves within the MELiSSA Higher Plant Compartments

    NASA Astrophysics Data System (ADS)

    Holmberg, Madeleine; Paille, Christel; Lasseur, Christophe

    The ESA project Micro Ecological Life Support System Alternative (MELiSSA) is an ecosystem of micro-organisms and higher plants, constructed with the objective of being operated as a tool to understand artificial ecosystems to be used for a long-term or permanent manned planetary base (e.g. Moon or Mars). The purpose of such a system is to provide for generation of food, water recycling, atmospheric regeneration and waste management within defined standards of quality and reliability. As MELiSSA consists of individual compartments which are connected to each other, the robustness of the system is fully dependent on the control of each compartment, as well as the flow management between them. Quality of consumables and reliability of the ecosystem rely on the knowledge, understanding and control of each of the components. This includes the full understanding of all processes related to the higher plants. To progress in that direction, this paper focuses on the mechanical processes driving the gas and liquid exchanges between the plant leaf and its environment. The process responsible for the mass transfer on the surface of plant leaves is diffusion. The diffusion flux is dependent on the behaviour of the stoma of the leaf and also on the leaf boundary layer (BL). In this paper, the physiology of the leaf is briefly examined in order to relate parameters such as light quality, light quantity, CO2 concentration, temperature, leaf water potential, humidity, vapour pressure deficit (VPD) gradients and pollutants to the opening or closing of stomata. The diffusion process is described theoretically and the description is compared to empirical approaches. The variables of the BL are examined and the effect airflow in the compartment has on the BL is investigated. Also presented is the impact changes in different environmental parameters may have on the fluid exchanges. Finally, some tests, to evaluate the accuracy of the concluded model, are suggested.

  8. The mapping of the human 52-kD Ro/SSA autoantigen gene to human chromosome II, and its polymorphisms

    SciTech Connect

    Frank, M.B.; Itoh, Kazuko ); Fujisaku, Atsushi ); Pontarotti, P. ); Mattei, M.G. ); Neas, B.R. Univ. of Oklahoma, Oklahoma City )

    1993-01-01

    Autoantibodies to the ribonucleoprotein Ro/SSA occur in nearly half of the patients with systemic lupus erythematosus and are associated with lymphopenia, photosensitive dermatitis, and pulmonary and renal disease, which suggests that they have an immunopathologic role. The majority of Ro/SSA precipitin-positive patients produce serum antibodies that bind to the 60-kD and 52-kD Ro/SSA proteins. The authors previously isolated and determined the nucleotide sequence of a cDNA clone that encodes the 52-kD form of the human Ro/SSA protein. In the present study, they have determined the chromosomal location of the gene by in situ hybridization to the end of the short arm of chromosome 11. Hybridization of portions of the cDNA probe to restriction enzyme-digested DNA indicated the gene is composed of at least three exons. The exon encoding the putative zinc fingers of this protein was found to be distinct from that which encodes the leucine zipper. An RFLP of this gene was identified and is associated with the presence of lupus, primarily in black Americans. 60 refs., 3 figs., 3 tabs.

  9. [Laboratory-based evaluation of "INOVA/QUANTA Lite" to determine antinuclear antibodies (ANA) and autoantibodies to double-stranded DNA, SS-A and SS-B].

    PubMed

    Yamauchi, Megumi S; Shingaki, Naohiko; Yamane, Nobuhisa

    2012-05-01

    We evaluated QUANTA Lite reagent series (INOVA Diagnostics, CA, USA) to determine antinuclear antibodies (ANA) and autoantibodies to double-stranded (ds) DNA, SS-A and SS-B, in parallel with MESACUP (Medical & Biological Laboratories, Nagoya). Overall agreements between two reagents for qualitative interpretation ranged from 77.5% (ANA) to 99.0%(anti-SS-B antibodies). When we compared to the results by indirect fluorescent antibody (IFA) test on HEp-2 cells, QUANTA Lite ANA demonstrated better sensitivity and specificity; 92.2% versus 76.5% in sensitivity and 92.1% versus 86.8% in specificity. Also, determining anti-chromatin antibodies and IFA test onto Chrithidia luciliae demonstrated greater interpretive correlation to detect anti-ds DNA by QUANTA Lite than by MESACUP. All the discrepant sera to which QUANTA Lite SS-A gave positive interpretations were confirmed to contain the antibodies specific to SS-A 52kDa antigen, which is supplemented to QUANTA Lite capture-probes. With these results, we can conclude that QUANTA Lite has superiorities over MESACUP; (1) to detect a variety of autoantibodies consisting of ANA, (2) to have a better correlation with confirmatory tests to detect anti-ds DNA antibodies, (3)to detect additional autoantibodies specific to SS-A 52kDa antigen, and (4) to have an enough compatibility in determining anti-SS-B antibodies.

  10. 78 FR 48170 - Privacy Act of 1974; CMS Computer Match No. 2013-12; HHS Computer Match No. 1307; SSA Computer...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-07

    ... Services Privacy Act of 1974; CMS Computer Match No. 2013-12; HHS Computer Match No. 1307; SSA Computer... Human Services (HHS). ACTION: Notice of Computer Matching Program (CMP). SUMMARY: In accordance with the....Wesolowski@cms.hhs.gov . SUPPLEMENTARY INFORMATION: The Computer Matching and Privacy Protection Act of 1988...

  11. 75 FR 30839 - Privacy Act of 1974; CMS Computer Match No. 2010-03, HHS Computer Match No. 1003, SSA Computer...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... HUMAN SERVICES Centers for Medicare & Medicaid Services Privacy Act of 1974; CMS Computer Match No. 2010-03, HHS Computer Match No. 1003, SSA Computer Match No. 1048, IRS Project No. 241 AGENCY: Department... renewal of an existing computer matching program (CMP) that has an expiration date of June 30, 2010...

  12. Induction of in vitro heart block is not restricted to affinity purified anti-52 kDa Ro/SSA antibody from mothers of children with neonatal lupus.

    PubMed

    Viana, V S; Garcia, S; Nascimento, J H; Elkon, K B; Brot, N; Campos de Carvalho, A C; Bonfá, E

    1998-01-01

    The ability of affinity purified anti-52 kDa Ro/SSA antibody from patients without obstetric history of neonatal lupus to cause heart block using an experimental model was investigated. IgG-enriched fractions from sera of 20 systemic lupus erythematosus (SLE) and one Sjögren's syndrome (SS) all positives for anti-Ro/SSA antibodies as detected by CIE, were perfused on isolated whole rabbit hearts. Only six (29%) samples induced A-V block, five of them presenting low anti-Ro/SSA titre. All of them recognized the 52 kDa isoform on ELISA whereas only one had a concomitant binding to the 60 kDa protein. Moreover, affinity purified antibodies from two sera previously known to induce A-V block were obtained by affinity chromatography using a column containing the full-length 52 kDa Ro/SSA fusion protein. Paired eluate and effluent devoid of anti-52 kDa activity from the same patient were individually perfused in whole hearts. The ability to cause cardiac blockade was restricted to the affinity anti-52 kDa eluates. In addition, anti-52 kDa eluates from three IgG fractions that primarily failed to induce blockade remained ineffective. The present study has added to our knowledge that affinity anti-52 kDa Ro/SSA antibodies from mothers with healthy infants are capable of causing in vitro cardiac conduction disturbances. A prospective follow up of these patients will better delineate the clinical usefulness of this experimental model.

  13. Common and specific associations of anti-SSA/Ro60 and anti-Ro52/TRIM21 antibodies in systemic lupus erythematosus.

    PubMed

    Menéndez, Aurora; Gómez, Jesús; Caminal-Montero, Luis; Díaz-López, José Bernardino; Cabezas-Rodríguez, Iván; Mozo, Lourdes

    2013-01-01

    Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE) features. In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients. Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 (P = 0.024 and P = 0.019, resp.) and anti-Ro52/TRIM21 (P = 0.026 and P = 0.022, resp.). In contrast, a negative association was detected regarding anti-phospholipid antibodies, anti-SSA/Ro60 having a stronger effect (P = 0.014) than anti-Ro52/TRIM21. Anti-SSA/Ro60 showed a specific positive association with hypocomplementemia (P = 0.041), mainly with low C4 levels (P = 0.008), whereas anti-Ro52/TRIM21 was found to be positively associated with Raynaud's phenomenon (P = 0.026) and cytopenia (P = 0.048) and negatively associated with anti-dsDNA (P = 0.013). Lymphocytes are involved in the relationship between anti-Ro52/TRIM21 and cytopenia since positive patients showed lower cell levels than negative patients (P = 0.036). In conclusion, anti-SSA/Ro60 and anti-Ro52/TRIM21 showed both common and specific associations in SLE. These data thus increase evidence of the different associations of the two anti-Ro specificities even in a particular disease.

  14. Plasma exchange effectively removes 52- and 60-kDa anti-Ro/SSA and anti-La/SSB antibodies in pregnant women with congenital heart block.

    PubMed

    Tonello, Marta; Ruffatti, Amelia; Marson, Piero; Tison, Tiziana; Marozio, Luca; Hoxha, Ariela; De Silvestro, Giustina; Punzi, Leonardo

    2015-07-01

    Pregnant women positive for 52- and 60-kDa anti-Ro/SSA and anti-La/SSB antibodies can suffer from congenital heart block (CHB), a passively acquired autoimmune disease. We evaluated the efficacy of plasma exchange (PE) in removing 52- and 60-kDa anti-Ro/SSA and anti-La/SSB antibodies in pregnant women with CHB treated with a combined therapy including PE, intravenous immunoglobulins, and steroids. Antibody levels were monitored in 10 consecutive pregnant women diagnosed with CHB and prospectively followed between 2009 and 2013. Assaying was performed using a homemade enzyme-linked immunosorbent assay test on blood samples collected immediately before and after PE sessions. A significant decrease in mean post-PE antibody levels was noted in all the cases examined. An analysis of antibody level trends in the samples collected before PE sessions showed that there was a steady, significant decrease in 90% of the patients with 52-kDa anti-Ro/SSA, in 80% of those with 60-kDa anti-Ro/SSA antibodies, and in 100% of those with anti-La/SSB antibodies. This study demonstrates that PE is effective in removing antibodies linked to the pathogenesis of CHB. PE treatment was found to have a long-term efficacy in all the women positive for anti-La/SSB antibodies and in most of the women positive for 52- and 60-kDa anti-Ro/SSA antibodies. It is interesting that the significant, immediate, and long-term fall in antibody levels that was observed in these patients took place in all the women whose CHB was reversed. This finding could give PE an important role in the treatment of CHB. © 2015 AABB.

  15. Common and Specific Associations of Anti-SSA/Ro60 and Anti-Ro52/TRIM21 Antibodies in Systemic Lupus Erythematosus

    PubMed Central

    Menéndez, Aurora; Gómez, Jesús; Caminal-Montero, Luis; Díaz-López, José Bernardino; Cabezas-Rodríguez, Iván; Mozo, Lourdes

    2013-01-01

    Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE) features. In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients. Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 (P = 0.024 and P = 0.019, resp.) and anti-Ro52/TRIM21 (P = 0.026 and P = 0.022, resp.). In contrast, a negative association was detected regarding anti-phospholipid antibodies, anti-SSA/Ro60 having a stronger effect (P = 0.014) than anti-Ro52/TRIM21. Anti-SSA/Ro60 showed a specific positive association with hypocomplementemia (P = 0.041), mainly with low C4 levels (P = 0.008), whereas anti-Ro52/TRIM21 was found to be positively associated with Raynaud's phenomenon (P = 0.026) and cytopenia (P = 0.048) and negatively associated with anti-dsDNA (P = 0.013). Lymphocytes are involved in the relationship between anti-Ro52/TRIM21 and cytopenia since positive patients showed lower cell levels than negative patients (P = 0.036). In conclusion, anti-SSA/Ro60 and anti-Ro52/TRIM21 showed both common and specific associations in SLE. These data thus increase evidence of the different associations of the two anti-Ro specificities even in a particular disease. PMID:24294139

  16. Radiations cosmiques : danger dans l'Espace

    NASA Astrophysics Data System (ADS)

    Bonnet-Bidaud, J. M.; Dzitko, H.

    2000-06-01

    Au sol, l'atmosphere nous protege plus ou moins bien. Mais dans l'espace ou a bord des avions de ligne, l'homme est directement expose aux rayonnements cosmiques qui peuvent etre mortels. Un veritable frein a la presence humaine prolongee dans l'espace. Une menace que les agences spatiales prennent tres au serieux.

  17. "Bohr's Atomic Model."

    ERIC Educational Resources Information Center

    Willden, Jeff

    2001-01-01

    "Bohr's Atomic Model" is a small interactive multimedia program that introduces the viewer to a simplified model of the atom. This interactive simulation lets students build an atom using an atomic construction set. The underlying design methodology for "Bohr's Atomic Model" is model-centered instruction, which means the central model of the…

  18. "Bohr's Atomic Model."

    ERIC Educational Resources Information Center

    Willden, Jeff

    2001-01-01

    "Bohr's Atomic Model" is a small interactive multimedia program that introduces the viewer to a simplified model of the atom. This interactive simulation lets students build an atom using an atomic construction set. The underlying design methodology for "Bohr's Atomic Model" is model-centered instruction, which means the central model of the…

  19. The atomic orbitals of the topological atom.

    PubMed

    Ramos-Cordoba, Eloy; Salvador, Pedro; Mayer, István

    2013-06-07

    The effective atomic orbitals have been realized in the framework of Bader's atoms in molecules theory for a general wavefunction. This formalism can be used to retrieve from any type of calculation a proper set of orthonormalized numerical atomic orbitals, with occupation numbers that sum up to the respective Quantum Theory of Atoms in Molecules (QTAIM) atomic populations. Experience shows that only a limited number of effective atomic orbitals exhibit significant occupation numbers. These correspond to atomic hybrids that closely resemble the core and valence shells of the atom. The occupation numbers of the remaining effective orbitals are almost negligible, except for atoms with hypervalent character. In addition, the molecular orbitals of a calculation can be exactly expressed as a linear combination of this orthonormalized set of numerical atomic orbitals, and the Mulliken population analysis carried out on this basis set exactly reproduces the original QTAIM atomic populations of the atoms. Approximate expansion of the molecular orbitals over a much reduced set of orthogonal atomic basis functions can also be accomplished to a very good accuracy with a singular value decomposition procedure.

  20. Atomic Energy Basics, Understanding the Atom Series.

    ERIC Educational Resources Information Center

    Atomic Energy Commission, Oak Ridge, TN. Div. of Technical Information.

    This booklet is part of the "Understanding the Atom Series," though it is a later edition and not included in the original set of 51 booklets. A basic survey of the principles of nuclear energy and most important applications are provided. These major topics are examined: matter has molecules and atoms, the atom has electrons, the nucleus,…

  1. Anti-RO/SSA and anti-La/SSB antibodies: Association with mild lupus manifestations in 645 childhood-onset systemic lupus erythematosus.

    PubMed

    Novak, Glaucia V; Marques, Mariana; Balbi, Verena; Gormezano, Natali W S; Kozu, Kátia; Sakamoto, Ana P; Pereira, Rosa M R; Terreri, Maria T; Magalhães, Claudia S; Guariento, Andressa; Sallum, Adriana M E; Marini, Roberto; Ferriani, Virginia Paes Leme; Barbosa, Cássia Maria; de Castro, Tânia Caroline Monteiro; Ramos, Valéria C; Bonfá, Eloisa; Silva, Clovis A

    2017-02-01

    To our knowledge there are no studies assessing anti-Ro/SSA and anti-La/SSB autoantibodies in a large population of childhood-systemic lupus erythematosus (cSLE) patients. This was a retrospective multicenter cohort study performed in 10 Pediatric Rheumatology services, São Paulo state, Brazil. Anti-Ro/SSA and anti-La/SSB antibodies were measured by enzyme linked immunosorbent assay (ELISA) in 645 cSLE patients. Anti-Ro/SSA and anti-La/SSB antibodies were evidenced in 209/645 (32%) and 102/645 (16%) of cSLE patients, respectively. Analysis of cSLE patients with and without anti-Ro/SSA antibodies revealed higher frequencies of malar rash (79% vs. 71%, p=0.032), photosensitivity (73% vs. 65%, p=0.035), cutaneous vasculitis (43% vs. 35%, p=0.046) and musculoskeletal involvement (82% vs. 75%, p=0.046) in spite of long and comparable disease duration in both groups (4.25 vs. 4.58years, p=0.973). Secondary Sjögren syndrome was observed in only five patients with this antibody (2.5% vs. 0%, p=0.0035), two of them with concomitant anti-La/SSB. The presence of associated autoantibodies: anti-Sm (50% vs. 30%, p<0.0001), anti-RNP (39% vs. 21%, p<0.0001) and anti-ribossomal P protein (46% vs. 21%, p=0.002) was also significantly higher in patients with anti-Ro/SAA antibodies. Further evaluation of cSLE patients with the presence of anti-La/SSB antibodies compared to those without these autoantibodies showed that the frequency of alopecia (70% vs. 51%, p=0.0005), anti-Sm (59% vs. 31%, p<0.0001) and anti-RNP (42% vs. 23%, p<0.0001) were significantly higher in the former group. Our large multicenter cohort study provided novel evidence in cSLE that anti-Ro/SSA and/or anti-La/SSB antibodies were associated with mild manifestations, particularly cutaneous and musculoskeletal. Secondary Sjögren syndrome was rarely observed in these patients, in spite of comparable frequencies of anti-Ro/SSA and/or anti-La/SSB reported for adult SLE. Copyright © 2016 Elsevier B.V. All rights

  2. MeLiSSA third compartment: a kinetic and stoichiometric study for Nitrosomonas europaea and Nitrobacter winogradskyi axenic cultures

    NASA Astrophysics Data System (ADS)

    Creuly, Catherine; Poughon, Laurent; Dussap, Claude-Gilles; Farges, Berangere

    2012-07-01

    As a part of a natural biological N-cycle, nitrification is one of the steps included in the conception of artificial ecosystems designed for extraterrestrial life support systems (LSS). In MELiSSA loop, which is based on carbon and nitrogen recycling, the non-edible part of the higher plants and the waste produced by the crew are collected in the liquefying compartment that degrades the chemically complex wastes into simpler building blocks (organic acids and CO2). The organic acids are eliminated in the second photoheterotrophic compartment letting an organic free medium mostly containing minerals and N-NH+4 nitrogen. The third compartment is in charge to re-oxidize N-NH+4 in order to make nitrogen usable by the following compartments. In MELiSSA, the constraint is to perform axenic cultures in order to fully control the genetic status of the culture and a thorough modelling for developing a control strategy of the compartment and of the loop, knowing that the reliability of the production of oxidized forms of nitrogen NO3- directly impacts the behaviour of the following compartments. Nitrification in aerobic environments is carried out by two groups of bacteria in co-cultures in a two-step process. The ammonia-oxidizing bacteria (Nitrosomonas europaea) realize the oxidation of ammonia to nitrite and the nitrite-oxidizing bacteria (Nitrobacter winogradskyi) the oxidation of nitrite to nitrate. In both cases, the bacteria achieve the oxidations to obtain an energy and reductant source for their growth and maintenance. Both groups use CO2 predominantly as their carbon source. They are typically found together in ecosystems and, consequently, nitrite accumulation is rare. This study concerns kinetic and mass balances studies of axenic cultures of Ns. europaea and Nb. winogradskyi in autotrophic conditions. The daily follow-up of these cultures is done using a new protocol involving flow cytometry and ionic chromatography. Nitrogen substrates and products are

  3. Lightning potential forecast over Nanjing with denoised sounding-derived indices based on SSA and CS-BP neural network

    NASA Astrophysics Data System (ADS)

    Wang, Jun; Sheng, Zheng; Zhou, Bihua; Zhou, Shudao

    2014-02-01

    The method of using the back propagation neural network improved by cuckoo search algorithm (hereafter CS-BP neural network) to forecast lightning occurrence from sounding-derived indices over Nanjing is presented. The general distribution features of lightning activities over Nanjing area are summarized and analyzed first. The sounding data of 156 thunderstorm days and 164 fair-weather days during the years 2007-2012 are used to calculate the values of sounding-derived indices. The indices are pre-filtered using singular spectrum analysis (hereafter SSA) as preprocessing technique and 4 most pertinent indices (namely CAPE, K, JI and SWEAT) are determined as inputs of CS-BP network by a linear bivariate analysis and selection algorithm. The cases of 2007-2010 are used to train CS-BP network and the cases of 2011-2012 are used as an independent sample to test the forecast performance. Some statistical skill score parameters (namely POD, SAR, CSI, et.al.) indicate that the CS-BP model excels in lightning forecasting and has a better performance compared with the traditional BP neural network and linear multiregression method.

  4. Effects of the Extraterrestrial Environment on Plants: Recommendations for Future Space Experiments for the MELiSSA Higher Plant Compartment.

    PubMed

    Wolff, Silje A; Coelho, Liz H; Karoliussen, Irene; Jost, Ann-Iren Kittang

    2014-05-05

    Due to logistical challenges, long-term human space exploration missions require a life support system capable of regenerating all the essentials for survival. Higher plants can be utilized to provide a continuous supply of fresh food, atmosphere revitalization, and clean water for humans. Plants can adapt to extreme environments on Earth, and model plants have been shown to grow and develop through a full life cycle in microgravity. However, more knowledge about the long term effects of the extraterrestrial environment on plant growth and development is necessary. The European Space Agency (ESA) has developed the Micro-Ecological Life Support System Alternative (MELiSSA) program to develop a closed regenerative life support system, based on micro-organisms and higher plant processes, with continuous recycling of resources. In this context, a literature review to analyze the impact of the space environments on higher plants, with focus on gravity levels, magnetic fields and radiation, has been performed. This communication presents a roadmap giving directions for future scientific activities within space plant cultivation. The roadmap aims to identify the research activities required before higher plants can be included in regenerative life support systems in space.

  5. Effects of the Extraterrestrial Environment on Plants: Recommendations for Future Space Experiments for the MELiSSA Higher Plant Compartment

    PubMed Central

    Wolff, Silje A.; Coelho, Liz H.; Karoliussen, Irene; Jost, Ann-Iren Kittang

    2014-01-01

    Due to logistical challenges, long-term human space exploration missions require a life support system capable of regenerating all the essentials for survival. Higher plants can be utilized to provide a continuous supply of fresh food, atmosphere revitalization, and clean water for humans. Plants can adapt to extreme environments on Earth, and model plants have been shown to grow and develop through a full life cycle in microgravity. However, more knowledge about the long term effects of the extraterrestrial environment on plant growth and development is necessary. The European Space Agency (ESA) has developed the Micro-Ecological Life Support System Alternative (MELiSSA) program to develop a closed regenerative life support system, based on micro-organisms and higher plant processes, with continuous recycling of resources. In this context, a literature review to analyze the impact of the space environments on higher plants, with focus on gravity levels, magnetic fields and radiation, has been performed. This communication presents a roadmap giving directions for future scientific activities within space plant cultivation. The roadmap aims to identify the research activities required before higher plants can be included in regenerative life support systems in space. PMID:25370192

  6. Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment options

    PubMed Central

    Costedoat-Chalumeau, Nathalie; Amoura, Zahir; Villain, Elisabeth; Cohen, Laurence; Piette, Jean-Charles

    2005-01-01

    Apart from complete and incomplete congenital heart block (CHB), new cardiac manifestations related to anti-SSA/Ro antibodies have been reported in children born to mothers bearing these antibodies. These manifestations include transient fetal first-degree heart block, prolongation of corrected QT (QTc) interval, sinus bradycardia, late-onset cardiomyopathy, endocardial fibroelastosis and cardiac malformations. Anti-SSA/Ro antibodies are not considered pathogenic to the adult heart, but a prolongation of the QTc interval has recently been reported in adult patients and is still a matter of debate. Treatment of CHB is not well established and needs to be assessed carefully. The risks and benefits of prenatal fluorinated steroids are discussed. PMID:15743492

  7. Exotic Atoms and Muonium

    NASA Astrophysics Data System (ADS)

    Horváth, D.

    In exotic atoms, one of the atomic electrons is replaced by a negatively charged particle, whereas muonium consists of a positive muon and an electron. After a general review of the theoretical and experimental aspects, the present knowledge of this field is summarized. These include muonium and the application of the muon spin resonance method in solid-state physics and chemistry, muonic hydrogen atoms, muonic molecules and muon-catalyzed fusion, pionic hydrogen atoms and their use in chemistry, testing quantum electrodynamics on heavy muonic atoms, measuring particle and nuclear properties using hadronic atoms, and testing basic symmetry principles with antiprotonic helium atoms and antihydrogen.

  8. Material Balance Based Modeling of BLSS with Matlab/Simulink. The MEliSSA Loop Case in Steady-State Conditions

    NASA Astrophysics Data System (ADS)

    Poughon, L.; Farges-Haddani, B.; Gros, J. B.; Du, C. G.

    Solving material balances in Biological Life Support Systems BLSS affords mass flow rates and chemical elements C H O N S P etc in all parts of these very intricate and complex systems this helps defining and optimizing the performance of the entire recycling loop in terms of closedness and necessary flow inputs The complete MELiSSA loop was modeled using MatLab Simulink and a mass balance simulator for the loop was released In order to build the complete MELiSSA loop material balance simulator with Matlab Simulink it was necessary 1- To establish steady-state models on the basis of mass-balances and elements-balances for each compartment and each subsystem of the loop for biological processes in the MELiSSA compartments within the loop stoichiometric equations including biomass were derived 2- To develop for each compartments and subsystems the associated Matlab Simulink S-blocks in which models are included 3- To assemble the different S-blocks of the loop flowchart giving as a result the flow rates in the entire recycling loop The simulation parameters are easily managed using the graphical dialog boxes The simulator is used to test the behavior of the loop in different operating conditions typically by varying the composition of the food produced in the loop

  9. Soilless cultivation of soybean for Bioregenerative Life-Support Systems: a literature review and the experience of the MELiSSA Project - Food characterisation Phase I.

    PubMed

    Paradiso, R; De Micco, V; Buonomo, R; Aronne, G; Barbieri, G; De Pascale, S

    2014-01-01

    Higher plants play a key role in Bioregenerative Life-Support Systems (BLSS) for long-term missions in space, by regenerating air through photosynthetic CO2 absorption and O2 emission, recovering water through transpiration and recycling waste products through mineral nutrition. In addition, plants could provide fresh food to integrate into the crew diet and help to preserve astronauts' wellbeing. The ESA programme Micro-Ecological Life-Support System Alternative (MELiSSA) aims to conceive an artificial bioregenerative ecosystem for resources regeneration, based on both microorganisms and higher plants. Soybean [Glycine max (L.) Merr.] is one of the four candidate species studied for soilless (hydroponic) cultivation in MELiSSA, because of the high nutritional value of the seeds. Within the MELiSSA programme - Food characterisation Phase I, the aim of the research carried out on soybean at the University of Naples was to select the most suitable European cultivars for cultivation in BLSS. In this context, a concise review on the state-of-the-art of soybean cultivation in space-oriented experiments and a summary of research activity for the preliminary theoretical selection and subsequent agronomical evaluation of four cultivars will be presented in this paper. © 2013 German Botanical Society and The Royal Botanical Society of the Netherlands.

  10. One-pot SSA-catalyzed β-elimination: an efficient and inexpensive protocol for easy access to the glycal of sialic acid.

    PubMed

    Paragas, Erickson M; Monreal, I Abrrey; Vasil, Chris M; Saludes, Jonel P

    2015-01-30

    Neu5Ac2en1Me per-OAc, the fully protected glycal of sialic acid, is a key intermediate in the discovery of therapeutics and diagnostics, including anti-influenza drugs and proteolysis resistant peptidomimetic foldamers. The synthesis of this sialic acid derivative, however, still relies on standard sugar chemistry that utilizes multi-step methodologies. Herein we report a facile and highly efficient microwave-assisted preparation of Neu5Ac1Me using silica sulfuric acid (SSA) as solid-supported acid catalyst that is one- to two-orders of magnitude faster than standard procedures. We also describe the microwave-assisted and SSA-catalyzed one-pot, rapid, solvent free reaction that combines both peracetylation and β-elimination reactions in one step to generate the glycal from Neu5Ac1Me. We coined the term One-pot SSA-catalyzed Technology for β-Elimination Protocol (OneSTEP) to describe this least laborious, most efficient, and practical preparation to date of Neu5Ac2en1Me per-OAc in terms of yield, time, reagent cost, and waste generation. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. One-pot SSA-catalyzed β-elimination: An efficient and inexpensive protocol for easy access to the glycal of sialic acid

    PubMed Central

    Paragas, Erickson M.; Monreal, I. Abrrey; Vasil, Chris M.; Saludes, Jonel P.

    2014-01-01

    Neu5Ac2en1Me per-OAc, the fully protected glycal of sialic acid, is a key intermediate in the discovery of therapeutics and diagnostics, including anti-influenza drugs and proteolysis resistant peptidomimetic foldamers. The synthesis of this sialic acid derivative, however, still relies on standard sugar chemistry that utilizes multi-step methodologies. Herein we report a facile and highly efficient microwave-assisted preparation of Neu5Ac1Me using silica sulfuric acid (SSA) as solid-supported acid catalyst that is one- to two-orders of magnitude faster than standard procedures. We also describe the microwave-assisted and SSA-catalyzed one-pot, rapid, solvent free reaction that combines both peracetylation and β-elimination reactions in one step to generate the glycal from Neu5Ac1Me. We coined the term One-pot SSA-catalyzed Technology for β-Elimination Protocol (OneSTEP) to describe this least laborious, most efficient, and practical preparation to date of Neu5Ac2en1Me per-OAc in terms of yield, time, reagent cost, and waste generation. PMID:25497336

  12. Neutral atom traps.

    SciTech Connect

    Pack, Michael Vern

    2008-12-01

    This report describes progress in designing a neutral atom trap capable of trapping sub millikelvin atom in a magnetic trap and shuttling the atoms across the atom chip from a collection area to an optical cavity. The numerical simulation and atom chip design are discussed. Also, discussed are preliminary calculations of quantum noise sources in Kerr nonlinear optics measurements based on electromagnetically induced transparency. These types of measurements may be important for quantum nondemolition measurements at the few photon limit.

  13. High Atom Number in Microsized Atom Traps

    DTIC Science & Technology

    2015-12-14

    2012 conference of the Division of Atomic , Molecular, and Optical Physics (DAMOP) of the American Physical Society (APS). We have reconfigured the...Final Performance Report on ONR Grant N00014-12-1-0608 High atom number in microsized atom traps for the period 15 May 2012 through 14 September...2015 J. M. Grossman Department of Physics St. Mary’s College of Maryland 18952 E. Fisher Road St. Mary’s City, MD 20686 jmgrossman @smcm. edu

  14. Gene transcript analysis blood values correlate with ⁶⁸Ga-DOTA-somatostatin analog (SSA) PET/CT imaging in neuroendocrine tumors and can define disease status.

    PubMed

    Bodei, L; Kidd, M; Modlin, I M; Prasad, V; Severi, S; Ambrosini, V; Kwekkeboom, D J; Krenning, E P; Baum, R P; Paganelli, G; Drozdov, I

    2015-08-01

    Precise determination of neuroendocrine tumor (NET) disease status and response to therapy remains a rate-limiting concern for disease management. This reflects limitations in biomarker specificity and resolution capacity of imaging. In order to evaluate biomarker precision and identify if combinatorial blood molecular markers and imaging could provide added diagnostic value, we assessed the concordance between (68)Ga-somatostatin analog (SSA) positron emission tomography (PET), circulating NET gene transcripts (NETest), chromogranin A (CgA), and Ki-67 in NETs. We utilized two independent patient groups with positive (68)Ga-SSA PET: data set 1 ((68)Ga-SSA PETs undertaken for peptide receptor radionuclide therapy (PRRT), as primary or salvage treatment, n = 27) and data set 2 ((68)Ga-SSA PETs performed in patients referred for initial disease staging or restaging after various therapies, n = 22). We examined the maximum standardized uptake value (SUVmax), circulating gene transcripts, CgA levels, and baseline Ki-67. Regression analyses, generalized linear modeling, and receiver-operating characteristic (ROC) analyses were undertaken to determine the strength of the relationships. SUVmax measured in two centers were mathematically evaluated (regression modeling) and determined to be comparable. Of 49 patients, 47 (96 %) exhibited a positive NETest. Twenty-six (54 %) had elevated CgA (χ(2) = 20.1, p < 2.5×10(-6)). The majority (78 %) had Ki-67 < 20 %. Gene transcript scores were predictive of imaging with >95 % concordance and significantly correlated with SUVmax (R (2) = 0.31, root-mean-square error = 9.4). The genes MORF4L2 and somatostatin receptors SSTR1, 3, and 5 exhibited the highest correlation with SUVmax. Progressive disease was identified by elevated levels of a quotient of MORF4L2 expression and SUVmax [ROC-derived AUC (R (2) = 0.7, p < 0.05)]. No statistical relationship was identified between CgA and Ki-67 and no

  15. Intrication de deux atomes en utilisant le blocage de Rydberg

    NASA Astrophysics Data System (ADS)

    Gaëtan, A.

    2010-12-01

    Considérons un système quantique constitué de deux sous-systèmes : on dit qu'il est dans un état intriqué s'il existe des corrélations quantiques entre les états de ces derniers. La compréhension et la mise en œuvre d'états intriqués ont de nombreuses applications (métrologie quantique, étude des systèmes fortement corrélés, traitement quantique de l'information, etc.) et constituent le contexte général de ce travail de thèse. Plus en détail, nous démontrons la réalisation d'un état intriqué de deux atomes neutres piégés indépendamment. Pour cela, nous exploitons le phénomène de blocage de Rydberg : lorsqu'on essaie d'exciter simultanément deux atomes séparés de quelques micromètres vers un état de Rydberg donné, la forte interaction entre atomes de Rydberg peut empêcher cette excitation simultanée. Dans ce cas, seul un des deux atomes est excité et l'on génère ainsi des corrélations quantiques entre les états des deux atomes, c'est-à-dire de l'intrication. Dans notre expérience, deux atomes de 87Rb dans l'état fondamental 5S1/2 sont piégés chacun dans une pince optique microscopique, à une distance relative de 4 micromètres. En réalisant des transitions entre l'état 5S1/2 et l'état de Rydberg 58D3/2 par des transitions à deux photons, nous obtenons un état intriqué des deux atomes dans les sous-niveaux |5S1/2, f = 1, mf = 1> et |5S1/2, f = 2, mf = 2>. Afin de quantifier l'intrication, nous mesurons la fidélité par rapport à l'état-cible en réalisant des transitions Raman entre ces deux sous-niveaux. La fidélité des paires d'atomes présentes à la fin de l'expérience est supérieure à la valeur seuil de 0,5, ce qui prouve la création d'un état intriqué.

  16. ALMA DEEP FIELD IN SSA22: A CONCENTRATION OF DUSTY STARBURSTS IN A z = 3.09 PROTOCLUSTER CORE

    SciTech Connect

    Umehata, H.; Ivison, R. J.; Tamura, Y.; Kohno, K.; Izumi, T.; Makiya, R.; Alexander, D. M.; Smail, I.; Geach, J. E.; Hatsukade, B.; Kato, Y.; Kawabe, R.; Lee, M.; Matsuda, Y.; Nakanishi, K.; Saito, T.; Hughes, D. H.; Ikarashi, S.; Kubo, M.; Lehmer, B.; and others

    2015-12-10

    We report the results of 1.′5 × 3′ mapping at 1.1 mm with the Atacama Large Millimeter/submillimeter Array toward the central region of the z = 3.09 SSA22 protocluster. By combining our source catalog with archival spectroscopic redshifts, we find that eight submillimeter galaxies (SMGs) with flux densities, S{sub 1.1} {sub mm} = 0.7–6.4 mJy (L{sub IR} ∼ 10{sup 12.1}–10{sup 13.1} L{sub ⊙}) are at z = 3.08–3.10. Not only are these SMGs members of the protocluster, but they in fact reside within the node at the junction of the 50 Mpc scale filamentary three-dimensional structure traced by Lyα emitters in this field. The eight SMGs account for a star formation rate density (SFRD) ∼10 M{sub ⊙} yr{sup −1} Mpc{sup −3} in the node, which is two orders of magnitudes higher than the global SFRD at this redshift. We find that four of the eight SMGs host an X-ray-luminous active galactic nucleus. Our results suggest that the vigorous star formation activity and the growth of supermassive black holes (SMBHs) occurred simultaneously in the densest regions at z ∼ 3, which may correspond to the most active historical phase of the massive galaxy population found in the core of the clusters in the present universe. Two SMGs are associated with Lyα blobs, implying that the two populations coexist in high-density environments for a few cases.

  17. The MELiSSA GreenMOSS Study: Preliminary Design Considerations for a Greenhouse Module on the Lunar Surface

    NASA Astrophysics Data System (ADS)

    Lobascio, Cesare; Paille, Christel; Lamantea, Matteo Maria; Boscheri, Giorgio; Rossetti, Vittorio

    Extended human presence on an extraterrestrial planetary surface will be made possible by the development of life support systems affordable in the long term. The key elements to support the goal will be the maximization of closure of air and water cycles, as well as the development of cost-effective and reliable hardware, including a careful strategic effort toward reduction of spare parts and consumables. Regenerative life support systems likely represent the final step toward long term sustainability of a space crew, allowing in situ food production and regeneration of organic waste. Referring to the MELiSSA loop, a key element for food production is the Higher Plant Compartment. The paper focuses on the preliminary design of a Greenhouse at the lunar South Pole, as performed within the “Greenhouse Module for Space System” (GreenMOSS) study, under a contract from the European Space Agency. The greenhouse is in support to a relatively small crew for provision of an energetic food complement. Resources necessary for the greenhouse such as water, carbon dioxide and nitrogen are assumed available, as required. The relevant mass and energy balances for incoming resources should be part of future studies, and should help integrate this element with the interfacing MELISSA compartments. Net oxygen production and harvested crop biomass from the greenhouse system will be quantified. This work presents the results of the two major trade-offs performed as part of this study: artificial vs natural illumination and monocrop vs multicrop solutions. Comparisons among possible design solutions were driven by the ALiSSE metric as far as practicable within this preliminary stage, considering mass and power parameters. Finally, the paper presents the mission duration threshold for determining the convenience of the designed solution with respect to other resources provision strategies

  18. Atomic Fuel, Understanding the Atom Series. Revised.

    ERIC Educational Resources Information Center

    Hogerton, John F.

    This publication is part of the "Understanding the Atom" series. Complete sets of the series are available free to teachers, schools, and public librarians who can make them available for reference or use by groups. Among the topics discussed are: What Atomic Fuel Is; The Odyssey of Uranium; Production of Uranium; Fabrication of Reactor…

  19. Atomic Particle Detection, Understanding the Atom Series.

    ERIC Educational Resources Information Center

    Hellman, Hal

    This booklet is one of the booklets in the "Understanding the Atom Series" published by the U. S. Atomic Energy Commission for high school science teachers and their students. The instruments used to detect both particles and electromagnetic radiation that emerge from the nucleus are described. The counters reviewed include ionization chambers,…

  20. PHYSICS: Toward Atom Chips.

    PubMed

    Fortágh, József; Zimmermann, Claus

    2005-02-11

    As a novel approach for turning the peculiar features of quantum mechanics into practical devices, researchers are investigating the use of ultracold atomic clouds above microchips. Such "atom chips" may find use as sensitive probes for gravity, acceleration, rotation, and tiny magnetic forces. In their Perspective, Fortagh and Zimmermann discuss recent advances toward creating atom chips, in which current-carrying conductors in the chips create magnetic microtraps that confine the atomic clouds. Despite some intrinsic limits to the performance of atom chips, existing technologies are capable of producing atom chips, and many possibilities for their construction remain to be explored.