Relations among Grade 4 Students' Perceptions of Autonomy, Engagement in Science, and Reading Motivation

ERIC Educational Resources Information Center

Taboada Barber, Ana; Buehl, Michelle M.

2013-01-01

The authors extend previous work on students' perceptions of teachers' autonomy-enhancing and autonomy-suppressing behaviors in relation to students' engagement to a more situated context (i.e., two Grade 4 science instructional conditions instead of school in general) and a linguistically diverse population (i.e., Hispanic students). They also…

Mathematics Instruction for Students with Emotional and Behavioral Disorders: A Best-Evidence Synthesis

ERIC Educational Resources Information Center

Ralston, Nicole C.; Benner, Gregory J.; Tsai, Shu-Fei; Riccomini, Paul J.; Nelson, J. Ron

2014-01-01

The authors report findings of a best-evidence synthesis of the effects of mathematics instruction on the mathematics skills of students with emotional and behavioral disorders. The goal of the synthesis was to extend previous research by (a) detailing independent variables, instructional components, and outcome measures for each study; (b)…

Do Nimble Hands Make for Nimble Lexicons? Fine Motor Skills Predict Knowledge of Embodied Vocabulary Items

ERIC Educational Resources Information Center

Suggate, Sebastian P.; Stoeger, Heidrun

2014-01-01

Theories and research in embodied cognition postulate that cognition grounded in action enjoys a processing advantage. Extending this theory to the study of how fine motor skills (FMS) link to vocabulary development in preschool children, the authors investigated FMS and vocabulary in 76 preschoolers. Building on previous research, they…

Resilient Youths Use Humor to Enhance Socioemotional Functioning during a "Day in the Life"

ERIC Educational Resources Information Center

Cameron, E. Leslie; Fox, Janice D.; Anderson, Michelle S.; Cameron, Catherine Ann

2010-01-01

In order to extend previous early years humor research into early adolescence, the authors adapted an innovative ecological research method such that at-risk adolescents could be filmed during an entire waking day in their life. Community youth advocates nominated one 15-year-old female and one 14-year-old male as doing well despite adverse…

Long Work Hours and Family Life: A Cross-National Study of Employees' Concerns

ERIC Educational Resources Information Center

Wharton, Amy S.; Blair-Loy, Mary

2006-01-01

Work-family conflict is a pressing research and policy issue. The authors extend previous scholarship on this issue by studying elite employees worries about the effects of long work hours on those in their personal life. This issue is researched cross-nationally in a sample of managers and professionals based in the United States, London, and…

Determinants of Success on the ETS Business Major Field Exam for Students in an Undergraduate Multisite Regional University Business Program

ERIC Educational Resources Information Center

Bagamery, Bruce D.; Lasik, John J.; Nixon, Don R.

2005-01-01

Extending previous studies, the authors examined a larger set of variables to identify predictors of student performance on the Educational Testing Service Major Field Exam in Business, which has been shown to be an externally valid measure of student learning outcomes. Significant predictors include gender, whether students took the SAT, and…

Mapping Functional Brain Development: Building a Social Brain through Interactive Specialization

ERIC Educational Resources Information Center

Johnson, Mark H.; Grossmann, Tobias; Kadosh, Kathrin Cohen

2009-01-01

The authors review a viewpoint on human functional brain development, interactive specialization (IS), and its application to the emerging network of cortical regions referred to as the "social brain." They advance the IS view in 2 new ways. First, they extend IS into a domain to which it has not previously been applied--the emergence of social…

78 FR 40687 - Magnuson-Stevens Act Provisions; Implementation of the Shark Conservation Act of 2010; Extension...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-08

.... Authority: 16 U.S.C. 1801 et seq. Dated: July 2, 2013. Alan D. Risenhoover, Director, Office of Sustainable... period. SUMMARY: NMFS published a proposed rule on May 2, 2013, to implement provisions of the Shark... the proposed rule was previously extended, and ends on July 8, 2013. NMFS has decided to further...

Child maltreatment among U.S. Air Force parents deployed in support of Operation Iraqi Freedom/Operation Enduring Freedom.

PubMed

Rabenhorst, Mandy M; McCarthy, Randy J; Thomsen, Cynthia J; Milner, Joel S; Travis, Wendy J; Colasanti, Marie P

2015-02-01

This study examined child maltreatment perpetration among 99,697 active-duty U.S. Air Force parents who completed a combat deployment. Using the deploying parent as the unit of analysis, we analyzed whether child maltreatment rates increased postdeployement relative to predeployment. These analyses extend previous research that used aggregate data and extend our previous work that used data from the same period but used the victim as the unit of analysis and included only deploying parents who engaged in child maltreatment. In this study, 2% (n = 1,746) of deploying parents perpetrated child maltreatment during the study period. Although no overall differences were found in child maltreatment rates postdeployment compared to predeployment, several maltreatment-related characteristics qualified this finding. Rates for emotional abuse and mild maltreatment were lower following deployment, whereas child maltreatment rates for severe maltreatment were higher following deployment. The finding that rates of severe child maltreatment, including incidents involving alcohol use, were higher postdeployment suggests a need for additional support services for parents following their return from combat deployment, with a focus on returning parents who have an alcohol use problem. © The Author(s) 2014.

41 CFR 302-8.1 - When may extended storage of HHG be authorized?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false When may extended... EXTENDED STORAGE OF HOUSEHOLD GOODS (HHG) General § 302-8.1 When may extended storage of HHG be authorized? Your agency may authorize extended storage of HHG under the following circumstances: (a) Extended...

41 CFR 302-8.1 - When may extended storage of HHG be authorized?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false When may extended... EXTENDED STORAGE OF HOUSEHOLD GOODS (HHG) General § 302-8.1 When may extended storage of HHG be authorized? Your agency may authorize extended storage of HHG under the following circumstances: (a) Extended...

41 CFR 302-8.1 - When may extended storage of HHG be authorized?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 4 2011-07-01 2011-07-01 false When may extended... EXTENDED STORAGE OF HOUSEHOLD GOODS (HHG) General § 302-8.1 When may extended storage of HHG be authorized? Your agency may authorize extended storage of HHG under the following circumstances: (a) Extended...

On-site wildland activity choices among African Americans and White Americans in the rural south: implications for management

Treesearch

Cassandra Y. Johnson; J. Michael Bowker

1999-01-01

Johnson and Bowker compare wildland activity choices for a sample of rural African Americans and Whites who visited wildland settings in and around the Apalachicola National Forest. The authors also look at intra-racial (same race, different gender) variations for activity participation. This research extends previous research focused on the visit/not visit wildland...

Putting the Learning in Case Learning? The Effects of Case-Based Approaches on Student Knowledge, Attitudes, and Engagement

ERIC Educational Resources Information Center

Krain, Matthew

2016-01-01

This study revisits case learning's effects on student engagement and assesses student learning as a result of the use of case studies and problem-based learning. The author replicates a previous study that used indirect assessment techniques to get at case learning's impact, and then extends the analysis using a pre- and post-test experimental…

Intelligent virtual reality in the setting of fuzzy sets

NASA Technical Reports Server (NTRS)

Dockery, John; Littman, David

1992-01-01

The authors have previously introduced the concept of virtual reality worlds governed by artificial intelligence. Creation of an intelligent virtual reality was further proposed as a universal interface for the handicapped. This paper extends consideration of intelligent virtual realty to a context in which fuzzy set principles are explored as a major tool for implementing theory in the domain of applications to the disabled.

The mediating role of job involvement in the relationship between job characteristics and organizational citizenship behavior.

PubMed

Chen, Chien-Cheng; Chiu, Su-Fen

2009-08-01

Past researchers have found that motivating job characteristics can increase employee display of organizational citizenship behavior (OCB). In this study, the authors extended previous research by investigating the mediating process of job involvement in the relationship between job characteristics and OCB. The authors collected data from 323 employees and their supervisors from 7 companies in Taiwan. Results show that, through the mediating process of job involvement, the 3 job characteristics (i.e., task identity, task significance, and autonomy) positively influenced the display of an employee's OCB, whereas skill variety had a negative effect on OCB. The authors discuss implications of their findings, contributions, limitations, and future research directions.

A century of transitions in New York City's measles dynamics.

PubMed

Hempel, Karsten; Earn, David J D

2015-05-06

Infectious diseases spreading in a human population occasionally exhibit sudden transitions in their qualitative dynamics. Previous work has successfully predicted such transitions in New York City's historical measles incidence using the seasonally forced susceptible-infectious-recovered (SIR) model. This work relied on a dataset spanning 45 years (1928-1973), which we have extended to 93 years (1891-1984). We identify additional dynamical transitions in the longer dataset and successfully explain them by analysing attractors and transients of the same mechanistic epidemiological model. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

The symbolic computation of series solutions to ordinary differential equations using trees (extended abstract)

NASA Technical Reports Server (NTRS)

Grossman, Robert

1991-01-01

Algorithms previously developed by the author give formulas which can be used for the efficient symbolic computation of series expansions to solutions of nonlinear systems of ordinary differential equations. As a by product of this analysis, formulas are derived which relate to trees to the coefficients of the series expansions, similar to the work of Leroux and Viennot, and Lamnabhi, Leroux and Viennot.

Collinear collision chemistry. II. Energy disposition in reactive collisions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahan, B.H.

1974-06-01

A model describing the mechanics of collinear atom-diatom collisions and previously reported by the author is extended to describe reactive collisions. The model indicates the effects of such factors as the mass distribution and potential energy barriers and wells on the reaction probability and on the distribution of energy among the modes of motion of the products. Simple geometry and trigonometry are sufficient to solve the model.

The impact of recreational MDMA 'ecstasy' use on global form processing.

PubMed

White, Claire; Edwards, Mark; Brown, John; Bell, Jason

2014-11-01

The ability to integrate local orientation information into a global form percept was investigated in long-term ecstasy users. Evidence suggests that ecstasy disrupts the serotonin system, with the visual areas of the brain being particularly susceptible. Previous research has found altered orientation processing in the primary visual area (V1) of users, thought to be due to disrupted serotonin-mediated lateral inhibition. The current study aimed to investigate whether orientation deficits extend to higher visual areas involved in global form processing. Forty-five participants completed a psychophysical (Glass pattern) study allowing an investigation into the mechanisms underlying global form processing and sensitivity to changes in the offset of the stimuli (jitter). A subgroup of polydrug-ecstasy users (n=6) with high ecstasy use had significantly higher thresholds for the detection of Glass patterns than controls (n=21, p=0.039) after Bonferroni correction. There was also a significant interaction between jitter level and drug-group, with polydrug-ecstasy users showing reduced sensitivity to alterations in jitter level (p=0.003). These results extend previous research, suggesting disrupted global form processing and reduced sensitivity to orientation jitter with ecstasy use. Further research is needed to investigate this finding in a larger sample of heavy ecstasy users and to differentiate the effects of other drugs. © The Author(s) 2014.

Translation and adaptation of smoking relapse-prevention materials for pregnant and postpartum Hispanic women.

PubMed

Simmons, Vani Nath; Cruz, Ligia M; Brandon, Thomas H; Quinn, Gwendolyn P

2011-01-01

Quitting smoking is one of the most important behavior changes a pregnant woman can make, with health benefits extending beyond pregnancy for the woman and her child. Increasing numbers of pregnant women are quitting smoking; however, the majority resume smoking later in their pregnancy or shortly after giving birth. Previous research has demonstrated the efficacy of self-help smoking relapse-prevention booklets; however, there is a dearth of materials available in Spanish for Hispanic smokers. The goal of the present study was to translate and adapt existing, theoretically based, smoking relapse-prevention materials for pregnant and postpartum Hispanic women. This article describes the transcreation approach used to ensure the Forever Free for Baby and Me booklets were linguistically and culturally relevant for the heterogeneous populations of Hispanic women. The authors conducted multistage formative research to adapt the booklets and modify vignettes and graphics. Compared with previous research conducted with pregnant non-Hispanic women, results revealed the following: (a) a lack of association or concern about smoking and weight gain, (b) the importance of family approval of behavior, and (c) stress related to difficulties surrounding the immigration experience. The authors' qualitative findings confirm and extend past research that has suggested ways to enhance the cultural relevance and acceptability of a health intervention.

ICU Acquisition Rate, Risk Factors, and Clinical Significance of Digestive Tract Colonization With Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae: A Systematic Review and Meta-Analysis.

PubMed

Detsis, Marios; Karanika, Styliani; Mylonakis, Eleftherios

2017-04-01

To evaluate the acquisition rate, identify risk factors, and estimate the risk for subsequent infection, associated with the colonization of the digestive tract with extended-spectrum beta-lactamase-producing Enterobacteriaceae during ICU-hospitalization. PubMed, EMBASE, and reference lists of all eligible articles. Included studies provided data on ICU-acquired colonization with extended-spectrum beta-lactamase-producing Enterobacteriaceae in previously noncolonized and noninfected patients and used the double disk synergy test for extended-spectrum beta-lactamase-producing Enterobacteriaceae phenotypic confirmation. Studies reporting extended-spectrum beta-lactamase-producing Enterobacteriaceae outbreaks or data on pediatric population were excluded. Two authors independently assessed study eligibility and performed data extraction. Thirteen studies (with 15,045 ICUs-patients) were evaluated using a random-effect model and a meta-regression analysis. The acquisition rate of digestive tract colonization during ICU stay was 7% (95% CI, 5-10) and it varies from 3% (95% CI, 2-4) and 4% (95% CI, 2-6) in the Americas and Europe to 21% (95% CI, 9-35) in the Western Pacific region. Previous hospitalization (risk ratio, 1.57 [95% CI, 1.07-2.31]) or antibiotic use (risk ratio, 1.65 [95% CI, 1.15-2.37]) and exposure to beta-lactams/beta-lactamase inhibitors (risk ratio, 1.78 [95% CI, 1.24-2.56]) and carbapenems (risk ratio, 2.13 [95% CI, 1.49-3.06]) during the ICU stay were independent risk factors for ICU-acquired colonization. Importantly, colonized patients were more likely to develop an extended-spectrum beta-lactamase-producing Enterobacteriaceae infection (risk ratio, 49.62 [95% CI, 20.42-120.58]). The sensitivity and specificity of prior colonization to predict subsequent extended-spectrum beta-lactamase-producing Enterobacteriaceae infection were 95.1% (95% CI, 54.7-99.7) and 89.2% (95% CI, 77.2-95.3), respectively. The ICU acquisition rate of extended-spectrum beta-lactamase-producing Enterobacteriaceae ranged from 5% to 10%. Previous use of beta-lactam/beta-lactamase or carbapenems and recent hospitalization were independent risk factors for extended-spectrum beta-lactamase-producing Enterobacteriaceae colonization, and colonization was associated with significantly higher frequency of extended-spectrum beta-lactamase-producing Enterobacteriaceae subsequent infection and increased mortality.

Impaired inference in a case of developmental amnesia.

PubMed

D'Angelo, Maria C; Rosenbaum, R Shayna; Ryan, Jennifer D

2016-10-01

Amnesia is associated with impairments in relational memory, which is critically supported by the hippocampus. By adapting the transitivity paradigm, we previously showed that age-related impairments in inference were mitigated when judgments could be predicated on known pairwise relations, however, such advantages were not observed in the adult-onset amnesic case D.A. Here, we replicate and extend this finding in a developmental amnesic case (N.C.), who also shows impaired relational learning and transitive expression. Unlike D.A., N.C.'s damage affected the extended hippocampal system and diencephalic structures, and does not extend to neocortical areas that are affected in D.A. Critically, despite their differences in etiology and affected structures, N.C. and D.A. perform similarly on the task. N.C. showed intact pairwise knowledge, suggesting that he is able to use existing semantic information, but this semantic knowledge was insufficient to support transitive expression. The present results suggest a critical role for regions connected to the hippocampus and/or medial prefrontal cortex in inference beyond learning of pairwise relations. © 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc. © 2016 The Authors. Wiley Periodicals, Inc.

The gender role motivation model of women's sexually submissive behavior and satisfaction in heterosexual couples.

PubMed

Sanchez, Diana T; Phelan, Julie E; Moss-Racusin, Corinne A; Good, Jessica J

2012-04-01

Previous findings suggest that women are more likely than men to take on the submissive role during sexual activities (e.g., waiting for their partner to initiate and orchestrate sexual activities), often to the detriment of their sexual satisfaction. Extending previous research on gender role motivation, the authors recruited 181 heterosexual couples to examine scripted sexual behavior, motivation for such behavior, and relationship outcomes (sexual satisfaction, perceptions of closeness, and relationship satisfaction) for both women and their partners. Using the actor-partner interdependence model, path analyses revealed that women's submissive behavior had negative links to personal sexual satisfaction and their partner's sexual satisfaction but only when their submission was inconsistent with their sexual preferences. Moreover, the authors show there are negative downstream consequences of diminished sexual satisfaction on perceptions of closeness and overall relationship satisfaction for both partners in the relationship.

An ecological process model of female sex offending: the role of victimization, psychological distress, and life stressors.

PubMed

DeCou, Christopher R; Cole, Trevor T; Rowland, Sarah E; Kaplan, Stephanie P; Lynch, Shannon M

2015-06-01

Female sex offenders may be implicated in up to one fifth of all sex crimes committed in the United States. Despite previous research findings that suggest unique patterns of offending among female sex offenders, limited empirical research has investigated the motivations and processes involved. The present study qualitatively examined female sex offenders' offense-related experiences and characterized the internal and external factors that contributed to offending. Semi-structured interviews with 24 female sex offenders were analyzed by a team of coders with limited exposure to the existing literature using grounded theory analysis. A conceptual framework emerged representing distinctive processes for solo- and co-offending, contextualized within ecological layers of social and environmental influence. This model extends previous work by offering an example of nested vulnerabilities proximal to female sexual offending. Implications for future research, prevention, and treatment are discussed. © The Author(s) 2014.

To provide a temporary extension of the Food, Conservation, and Energy Act of 2008 and amendments made by that Act, as previously extended and amended and with certain additional modifications and exceptions, to suspend permanent price support authorities, and for other purposes.

THOMAS, 113th Congress

Rep. Lucas, Frank D. [R-OK-3

2013-12-11

Senate - 12/12/2013 Received in the Senate and Read twice and referred to the Committee on Agriculture, Nutrition, and Forestry. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

47 CFR 73.99 - Presunrise service authorization (PSRA) and postsunset service authorization (PSSA).

Code of Federal Regulations, 2013 CFR

2013-10-01

... authorization. (c) Extended Daylight Saving Time Pre-Sunrise Authorizations: (1) Between the first Sunday in... presunrise operations during extended daylight saving time and shall issue conforming authorizations. These...

47 CFR 73.99 - Presunrise service authorization (PSRA) and postsunset service authorization (PSSA).

Code of Federal Regulations, 2011 CFR

2011-10-01

... authorization. (c) Extended Daylight Saving Time Pre-Sunrise Authorizations: (1) Between the first Sunday in... presunrise operations during extended daylight saving time and shall issue conforming authorizations. These...

Role of hybridization in the superconducting properties of an extended d p Hubbard model: a detailed numerical study

NASA Astrophysics Data System (ADS)

Calegari, E. J.; Magalhães, S. G.; Gomes, A. A.

2005-04-01

The Roth's two-pole approximation has been used by the present authors to study the effects of the hybridization in the superconducting properties of a strongly correlated electron system. The model used is the extended Hubbard model which includes the d-p hybridization, the p-band and a narrow d-band. The present work is an extension of our previous work (J. Mod. Phys. B 18(2) (2004) 241). Nevertheless, some important correlation functions necessary to estimate the Roth's band shift, are included together with the temperature T and the Coulomb interaction U to describe the superconductivity. The superconducting order parameter of a cuprate system, is obtained following Beenen and Edwards formalism. Here, we investigate in detail the change of the order parameter associated to temperature, Coulomb interaction and Roth's band shift effects on superconductivity. The phase diagram with Tc versus the total occupation number nT, shows the difference respect to the previous work.

Quantum dynamics calculations using symmetrized, orthogonal Weyl-Heisenberg wavelets with a phase space truncation scheme. III. Representations and calculations.

PubMed

Poirier, Bill; Salam, A

2004-07-22

In a previous paper [J. Theo. Comput. Chem. 2, 65 (2003)], one of the authors (B.P.) presented a method for solving the multidimensional Schrodinger equation, using modified Wilson-Daubechies wavelets, and a simple phase space truncation scheme. Unprecedented numerical efficiency was achieved, enabling a ten-dimensional calculation of nearly 600 eigenvalues to be performed using direct matrix diagonalization techniques. In a second paper [J. Chem. Phys. 121, 1690 (2004)], and in this paper, we extend and elaborate upon the previous work in several important ways. The second paper focuses on construction and optimization of the wavelength functions, from theoretical and numerical viewpoints, and also examines their localization. This paper deals with their use in representations and eigenproblem calculations, which are extended to 15-dimensional systems. Even higher dimensionalities are possible using more sophisticated linear algebra techniques. This approach is ideally suited to rovibrational spectroscopy applications, but can be used in any context where differential equations are involved.

genepop'007: a complete re-implementation of the genepop software for Windows and Linux.

PubMed

Rousset, François

2008-01-01

This note summarizes developments of the genepop software since its first description in 1995, and in particular those new to version 4.0: an extended input format, several estimators of neighbourhood size under isolation by distance, new estimators and confidence intervals for null allele frequency, and less important extensions to previous options. genepop now runs under Linux as well as under Windows, and can be entirely controlled by batch calls. © 2007 The Author.

Fallout sup 131 I in western Nevada cattle thyroid glands: 1962-early 1969

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blincoe, C.; Bohman, V.R.

1991-10-01

There has been continuing interest in historical fallout data. The authors have previously published data concerning the concentrations of fallout radioactive {sup 131}I in the thyroid glands of cattle from the Nevada Test Site and from commercial slaughter cattle. These data showed that bovine thyroid {sup 131}I was an effective monitor of both local and worldwide fresh nuclear fallout. This paper extends the data on commercial slaughter cattle from western Nevada through early 1969.

Effect of Macroscopic Impurities on Resistive Measurements in Three Dimensions

NASA Astrophysics Data System (ADS)

Koon, Daniel W.

1997-03-01

The authors extend their study of the effect of macroscopic impurities on resistive measurements to include specimens of finite thickness. The effect of such impurities is calculated for a rectangular parallelepiped with two current and two voltage contacts on the corners of one of its faces. The weighting function(D. W. Koon and C. J. Knickerbocker, Rev. Sci. Instrum. 63, 207 (1992).) displays singularities near these contacts, but these are shown to vanish in the two-dimensional limit, in agreement with previous results.

Speed-of-light limitations in passive linear media

NASA Astrophysics Data System (ADS)

Welters, Aaron; Avniel, Yehuda; Johnson, Steven G.

2014-08-01

We prove that well-known speed-of-light restrictions on electromagnetic energy velocity can be extended to a new level of generality, encompassing even nonlocal chiral media in periodic geometries, while at the same time weakening the underlying assumptions to only passivity and linearity of the medium (either with a transparency window or with dissipation). As was also shown by other authors under more limiting assumptions, passivity alone is sufficient to guarantee causality and positivity of the energy density (with no thermodynamic assumptions). Our proof is general enough to include a very broad range of material properties, including anisotropy, bianisotropy (chirality), nonlocality, dispersion, periodicity, and even delta functions or similar generalized functions. We also show that the "dynamical energy density" used by some previous authors in dissipative media reduces to the standard Brillouin formula for dispersive energy density in a transparency window. The results in this paper are proved by exploiting deep results from linear-response theory, harmonic analysis, and functional analysis that had previously not been brought together in the context of electrodynamics.

Book review: Current perspectives on zinc deposits

USGS Publications Warehouse

Kelley, Karen D.

2016-01-01

This book, published in 2015 by the Irish Association for Economic Geology (IAEG), is a compilation of papers and abstracts written by selected authors who attended the ZINC 2010 Conference in Cork, Ireland. Unlike most books produced each decade by the IAEG, which are focused primarily on achievements of the Irish and European mineral sectors, this book has a global perspective of a single commodity—zinc. As stated in the Preface, the theme of the conference and book was quite relevant for the IAEG because Ireland has the highest concentration of zinc per square kilometer on the planet. The book contains 7 full papers and 5 extended abstracts by keynote speakers, followed by 17 extended abstracts by other presenters, plus an Appendix (reprint) of a previously published paper.

Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus.

PubMed

Demirci, F Yesim; Wang, Xingbin; Morris, David L; Feingold, Eleanor; Bernatsky, Sasha; Pineau, Christian; Clarke, Ann; Ramsey-Goldman, Rosalind; Manzi, Susan; Vyse, Timothy J; Kamboh, M I

2017-06-01

A major systemic lupus erythematosus (SLE) susceptibility locus lies within a common inversion polymorphism region (encompassing 3.8 - 4.5  Mb) located at 8p23. Initially implicated genes included FAM167A-BLK and XKR6 , of which BLK received major attention due to its known role in B-cell biology. Recently, additional SLE risk carried in non-inverted background was also reported. In this case -control study, we further investigated the 'extended' 8p23 locus (~ 4  Mb) where we observed multiple SLE signals and assessed these signals for their relation to the inversion affecting this region. The study involved a North American discovery data set ( ~ 1200  subjects) and a replication data set (> 10 000  subjects) comprising European-descent individuals. Meta-analysis of 8p23 SNPs, with p < 0.05 in both data sets, identified 51 genome-wide significant SNPs (p < 5.0 × 10 -8 ). While most of these SNPs were related to previously implicated signals ( XKR6-FAM167A-BLK subregion), our results also revealed two 'new' SLE signals, including SGK223-CLDN23-MFHAS1 (6.06 × 10 -9 ≤ meta p ≤ 4.88 × 10 -8 ) and CTSB (meta p = 4.87 × 10 -8 ) subregions that are located > 2 Mb upstream and ~ 0.3  Mb downstream from previously reported signals. Functional assessment of relevant SNPs indicated putative cis -effects on the expression of various genes at 8p23. Additional analyses in discovery sample, where the inversion genotypes were inferred, replicated the association of non-inverted status with SLE risk and suggested that a number of SLE risk alleles are predominantly carried in non-inverted background. Our results implicate multiple (known+novel) SLE signals/genes at the extended 8p23 locus, beyond previously reported signals/genes, and suggest that this broad locus contributes to SLE risk through the effects of multiple genes/pathways. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Modeling Bivariate Change in Individual Differences: Prospective Associations Between Personality and Life Satisfaction.

PubMed

Hounkpatin, Hilda Osafo; Boyce, Christopher J; Dunn, Graham; Wood, Alex M

2017-09-18

A number of structural equation models have been developed to examine change in 1 variable or the longitudinal association between 2 variables. The most common of these are the latent growth model, the autoregressive cross-lagged model, the autoregressive latent trajectory model, and the latent change score model. The authors first overview each of these models through evaluating their different assumptions surrounding the nature of change and how these assumptions may result in different data interpretations. They then, to elucidate these issues in an empirical example, examine the longitudinal association between personality traits and life satisfaction. In a representative Dutch sample (N = 8,320), with participants providing data on both personality and life satisfaction measures every 2 years over an 8-year period, the authors reproduce findings from previous research. However, some of the structural equation models overviewed have not previously been applied to the personality-life satisfaction relation. The extended empirical examination suggests intraindividual changes in life satisfaction predict subsequent intraindividual changes in personality traits. The availability of data sets with 3 or more assessment waves allows the application of more advanced structural equation models such as the autoregressive latent trajectory or the extended latent change score model, which accounts for the complex dynamic nature of change processes and allows stronger inferences on the nature of the association between variables. However, the choice of model should be determined by theories of change processes in the variables being studied. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Do patients have duties?

PubMed Central

Evans, H M

2007-01-01

The notion of patients' duties has received periodic scholarly attention but remains overwhelmed by attention to the duties of healthcare professionals. In a previous paper the author argued that patients in publicly funded healthcare systems have a duty to participate in clinical research, arising from their debt to previous patients. Here the author proposes a greatly extended range of patients' duties grounding their moral force distinctively in the interests of contemporary and future patients, since medical treatment offered to one patient is always liable to be an opportunity cost (however justifiable) in terms of medical treatment needed by other patients. This generates both negative and positive duties. Ten duties—enjoining obligations ranging from participation in healthcare schemes to promoting one's own earliest recovery from illness—are proposed. The characteristics of these duties, including their basis, moral force, extent and enforceability, are considered. They are tested against a range of objections—principled, societal, epistemological and practical—and found to survive. Finally, the paper suggests that these duties could be thought to reinforce a regrettably adversarial characteristic, shared with rights‐based approaches, and that a preferable alternative might be sought through the (here unexplored) notion of a “virtuous patient” contributing to a problem‐solving partnership with the clinician. However, in defining and giving content to that partnership, there is a clear role for most, if not all, of the proposed duties; their value thus extends beyond the adversarial context in which they might first be thought to arise. PMID:18055897

Comments on "Killer whale (Orcinus orca) behavioral audiograms" [J. Acoust. Soc. Am. 141, 2387-2398 (2017)].

PubMed

Heffner, Henry E; Heffner, Rickye S

2018-01-01

Branstetter and his colleagues present the audiograms of eight killer whales and provide a comprehensive review of previous killer whale audiograms. In their paper, they say that the present authors have reported a relationship between size and high-frequency hearing but that echolocating cetaceans might be a special case. The purpose of these comments is to clarify that the relationship of a species' high-frequency hearing is not to its size (mass) but to its "functional interaural distance" (a measure of the availability of sound-localization cues). Moreover, it has previously been noted that echolocating animals, cetaceans as well as bats, have extended their high-frequency hearing somewhat beyond the frequencies used by comparable non-echolocators for passive localization.

The implications of linking the dynamic performance and turnover literatures.

PubMed

Sturman, M C; Trevor, C O

2001-08-01

This article examines how the literatures of dynamic performance and the performance-turnover relationship inform each other. The nonrandom performance turnover relationship suggests that dynamic performance studies may be biased by their elimination of participants who do not remain for the entire study period. The authors demonstrated that the performance slopes of those who leave an organization differ from the performance slopes of those who remain. This finding suggests that studies of the performance-turnover relationship need to consider employee performance trends when predicting turnover. Replicating and extending the research of D. A. Harrison, M. Virick, and S. William (1996), the authors found that performance changes from the previous month and performance trends measured over a longer time period explained variance in voluntary turnover beyond current performance. Finally, the authors showed that performance trends interacted with current performance in the prediction of voluntary turnover.

Identification and interpretation of tectonic features from Skylab imagery. [California to Arizona

NASA Technical Reports Server (NTRS)

Abdel-Gawad, M. (Principal Investigator)

1974-01-01

The author has identified the following significant results. S190-B imagery confirmed previous conclusions from S190-A that the Garlock fault does not extend eastward beyond its known termination near the southern end of Death Valley. In the Avawatz Mountains, California, two faults related to the Garlock fault zone (Mule Spring fault and Leach Spring fault) show evidence of recent activity. There is evidence that faulting related to Death Valley fault zone extends southeastward across the Old Dad Mountains. There, the Old Dad fault shows evidence of recent activity. A significant fault lineament has been identified from McCullough Range, California southeastward to Eagle Tail Mountains in southwestern Arizona. The lineament appears to control tertiary and possible cretaceous intrusives. Considerable right lateral shear is suspected to have taken place along parts of this lineament.

Jurassic Lake T'oo'dichi': a large alkaline, saline lake, Morrison Formation, eastern Colorado Plateau

USGS Publications Warehouse

Turner, C.E.; Fishman, N.S.

1991-01-01

Recognition of alkaline, saline-lake deposits in the Morrison Formation significantly alters interpretations of depositional environments of this formation, and it also has important implications for paleoclimatic interpretation. Late Jurassic climate was apparently much more arid than had previously been thought. In fact, sedimentologic evidence suggests that the lake basin was typically dry for extended periods and enjoyed only brief wet intervals. This conclusion has important consequences for environmental interpretation of the habitat that was favorable for large herbivorous dinosaurs, which thrived in the Late Jurassic. -from Authors

The optimal manufacturing batch size with rework under time-varying demand process for a finite time horizon

NASA Astrophysics Data System (ADS)

Musa, Sarah; Supadi, Siti Suzlin; Omar, Mohd

2014-07-01

Rework is one of the solutions to some of the main issues in reverse logistic and green supply chain as it reduces production cost and environmental problem. Many researchers focus on developing rework model, but to the knowledge of the author, none of them has developed a model for time-varying demand rate. In this paper, we extend previous works and develop multiple batch production system for time-varying demand rate with rework. In this model, the rework is done within the same production cycle.

Educating nurses to protect the past or to advance health care?: A polemic.

PubMed

Nay, R; Pearson, A

2001-01-01

Internationally, nursing is challenged by recruitment and retention issues. On the one hand nursing is expanding and extending practice whilst on the other, lesser skilled workers are undertaking many roles which were previously fulfilled by nurses. This opinion paper contextualises the current debate and outlines many of the reasons that have been proffered for the apparent shortage. It then progresses to suggest strategies that may ensure nursing remains relevant to contemporary health care. Essentially a presentation of the authors' views, the intent of the paper is to generate debate.

41 CFR 302-8.401 - How should we administer the authorization and payment of extended storage of HHG?

Code of Federal Regulations, 2010 CFR

2010-07-01

... the authorization and payment of extended storage of HHG? 302-8.401 Section 302-8.401 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES TRANSPORTATION AND STORAGE OF PROPERTY 8-ALLOWANCES FOR EXTENDED STORAGE OF HOUSEHOLD GOODS (HHG) Agency Responsibilities...

Expanding the Entamoeba Universe: New Hosts Yield Novel Ribosomal Lineages.

PubMed

Jacob, Alison S; Busby, Eloise J; Levy, Abigail D; Komm, Natasha; Clark, C Graham

2016-01-01

Removing the requirement for cell culture has led to a substantial increase in the number of lineages of Entamoeba recognized as distinct. Surveying the range of potential host species for this parasite genus has barely been started and it is clear that additional sampling of the same host in different locations often identifies additional diversity. In this study, using small subunit ribosomal RNA gene sequencing, we identify four new lineages of Entamoeba, including the first report of Entamoeba from an elephant, and extend the host range of some previously described lineages. In addition, examination of microbiome data from a number of host animals suggests that substantial Entamoeba diversity remains to be uncovered. © 2015 The Author(s) Journal of Eukaryotic Microbiology © 2015 International Society of Protistologists.

Thrust imbalance of solid rocket motor pairs on Space Shuttle flights

NASA Technical Reports Server (NTRS)

Foster, W. A., Jr.; Shu, P. H.; Sforzini, R. H.

1986-01-01

This analysis extends the investigation presented at the 17th Joint Propulsion Conference in 1981 to include fifteen sets of Space Shuttle flight data. The previous report dealt only with static test data and the first flight pair. The objective is to compare the authors' previous theoretical analysis of thrust imbalance with actual Space Shuttle performance. The theoretical prediction method, which involves a Monte Carlo technique, is reviewed briefly as are salient features of the flight instrumentation system and the statistical analysis. A scheme for smoothing flight data is discussed. The effects of changes in design parameters are discussed with special emphasis on the filament wound motor case being developed to replace the steel case. Good agreement between the predictions and the flight data is demonstrated.

Extension of the general thermal field equation for nanosized emitters

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kyritsakis, A., E-mail: akyritsos1@gmail.com; Xanthakis, J. P.

2016-01-28

During the previous decade, Jensen et al. developed a general analytical model that successfully describes electron emission from metals both in the field and thermionic regimes, as well as in the transition region. In that development, the standard image corrected triangular potential barrier was used. This barrier model is valid only for planar surfaces and therefore cannot be used in general for modern nanometric emitters. In a recent publication, the authors showed that the standard Fowler-Nordheim theory can be generalized for highly curved emitters if a quadratic term is included to the potential model. In this paper, we extend thismore » generalization for high temperatures and include both the thermal and intermediate regimes. This is achieved by applying the general method developed by Jensen to the quadratic barrier model of our previous publication. We obtain results that are in good agreement with fully numerical calculations for radii R > 4 nm, while our calculated current density differs by a factor up to 27 from the one predicted by the Jensen's standard General-Thermal-Field (GTF) equation. Our extended GTF equation has application to modern sharp electron sources, beam simulation models, and vacuum breakdown theory.« less

Extended evolution: A conceptual framework for integrating regulatory networks and niche construction

PubMed Central

Renn, Jürgen

2015-01-01

ABSTRACT This paper introduces a conceptual framework for the evolution of complex systems based on the integration of regulatory network and niche construction theories. It is designed to apply equally to cases of biological, social and cultural evolution. Within the conceptual framework we focus especially on the transformation of complex networks through the linked processes of externalization and internalization of causal factors between regulatory networks and their corresponding niches and argue that these are an important part of evolutionary explanations. This conceptual framework extends previous evolutionary models and focuses on several challenges, such as the path‐dependent nature of evolutionary change, the dynamics of evolutionary innovation and the expansion of inheritance systems. J. Exp. Zool. (Mol. Dev. Evol.) 324B: 565–577, 2015. © 2015 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals, Inc. PMID:26097188

Identification of four novel variants that influence central corneal thickness in multi-ethnic Asian populations.

PubMed

Cornes, Belinda K; Khor, Chiea Chuen; Nongpiur, Monisha E; Xu, Liang; Tay, Wan-Ting; Zheng, Yingfeng; Lavanya, Raghavan; Li, Yang; Wu, Renyi; Sim, Xueling; Wang, Ya-Xing; Chen, Peng; Teo, Yik Ying; Chia, Kee-Seng; Seielstad, Mark; Liu, Jianjun; Hibberd, Martin L; Cheng, Ching-Yu; Saw, Seang-Mei; Tai, E-Shyong; Jonas, Jost B; Vithana, Eranga N; Wong, Tien Y; Aung, Tin

2012-01-15

Central corneal thickness (CCT) is a highly heritable trait. Genes that significantly influence CCT can be candidate genes for common disorders in which CCT has been implicated, such as primary open-angle glaucoma (POAG) and keratoconus. Because the genetic factors controlling CCT in different Asian populations are unclear, we have built on previous work conducted on Singaporean Indians and Malays and extended our hypothesis to individuals of Chinese descent. We have followed up on all suggestive signals of association with CCT (P < 10(-4)) from the previously reported meta-analysis comprising Indians and Malays in a sample of Chinese individuals (n= 2681). In the combined sample (n= 7711), strong evidence of association was observed at four novel loci: IBTK on chromosome 6q14.1; CHSY1 on chromosome 15q26.3; and intergenic regions on chromosomes 7q11.2 and 9p23 (8.01 × 10(-11) < λ(GC) corrected P(meta) < 8.72 × 10(-8)). These four new loci explain an additional 4.3% of the total CCT variance across the sample cohorts over and above that of previously identified loci. We also extend on a previous finding at a fifth locus (AKAP13) where a new single-nucleotide polymorphism (rs1821481, P(meta) = 9.99 × 10(-9)) was found to be significantly more informative compared with the previously reported rs6496932 (P(meta) = 3.64 × 10(-5)). Performing association analysis in Asians may lead to the discovery of ethnic-specific genes that control CCT, offering further mechanistic insights into the regulation of CCT. In addition, it may also provide several candidate genes for interrogation for POAG, keratoconus and possible racial/ethnic variations. © The Author 2011. Published by Oxford University Press. All rights reserved.

An analytical method to predict efficiency of aircraft gearboxes

NASA Technical Reports Server (NTRS)

Anderson, N. E.; Loewenthal, S. H.; Black, J. D.

1984-01-01

A spur gear efficiency prediction method previously developed by the authors was extended to include power loss of planetary gearsets. A friction coefficient model was developed for MIL-L-7808 oil based on disc machine data. This combined with the recent capability of predicting losses in spur gears of nonstandard proportions allows the calculation of power loss for complete aircraft gearboxes that utilize spur gears. The method was applied to the T56/501 turboprop gearbox and compared with measured test data. Bearing losses were calculated with large scale computer programs. Breakdowns of the gearbox losses point out areas for possible improvement.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kwasniewski, Bartosz K

The construction of reversible extensions of dynamical systems presented in a previous paper by the author and A.V. Lebedev is enhanced, so that it applies to arbitrary mappings (not necessarily with open range). It is based on calculating the maximal ideal space of C*-algebras that extends endomorphisms to partial automorphisms via partial isometric representations, and involves a new set of 'parameters' (the role of parameters is played by chosen sets or ideals). As model examples, we give a thorough description of reversible extensions of logistic maps and a classification of systems associated with compression of unitaries generating homeomorphisms of themore » circle. Bibliography: 34 titles.« less

Experiment to evaluate feasibility of utilizing Skylab-EREP remote sensing data for tectonic analysis of the Bighorn Mountains region, Wyoming-Montana

NASA Technical Reports Server (NTRS)

Hoppin, R. A. (Principal Investigator)

1974-01-01

The author has identified the following significant results. Analysis of SL-3, S-190A, and S-190B color frames indicates two sets of linears obliquely cutting across the east-west trending Owl Creek-Bridger uplifts. A northwest set of faults and folds has been mapped previously but the imagery indicates some changes and addition of detail can be made. A less pronounced east-northeast set of linear alignments (drainage segments, lithologic contacts, possible faults) extends into the southeast part of the Big Horn Basin.

Resistive and Hall weighting functions in three dimensions

NASA Astrophysics Data System (ADS)

Koon, D. W.; Knickerbocker, C. J.

1998-10-01

The authors extend their study of the effect of macroscopic impurities on resistive and Hall measurements to include objects of finite thickness. The effect of such impurities is calculated for a series of rectangular parallelepipeds with two current and two voltage contacts on the corners of one square face. The weighting functions display singularities near these contacts, but these are shown to vanish in the two-dimensional limit, in agreement with previous results. Finally, it is shown that while Hall measurements principally sample the plane of the electrodes, resistivity measurements sample more of the interior of an object of finite thickness.

41 CFR 302-8.3 - How will I know when my agency has made a decision to authorize extended storage of my HHG?

Code of Federal Regulations, 2010 CFR

2010-07-01

... agency has made a decision to authorize extended storage of my HHG? 302-8.3 Section 302-8.3 Public Contracts and Property Management Federal Travel Regulation System RELOCATION ALLOWANCES TRANSPORTATION AND STORAGE OF PROPERTY 8-ALLOWANCES FOR EXTENDED STORAGE OF HOUSEHOLD GOODS (HHG) General § 302-8.3 How will...

Descriptive Statistics for Modern Test Score Distributions: Skewness, Kurtosis, Discreteness, and Ceiling Effects.

PubMed

Ho, Andrew D; Yu, Carol C

2015-06-01

Many statistical analyses benefit from the assumption that unconditional or conditional distributions are continuous and normal. More than 50 years ago in this journal, Lord and Cook chronicled departures from normality in educational tests, and Micerri similarly showed that the normality assumption is met rarely in educational and psychological practice. In this article, the authors extend these previous analyses to state-level educational test score distributions that are an increasingly common target of high-stakes analysis and interpretation. Among 504 scale-score and raw-score distributions from state testing programs from recent years, nonnormal distributions are common and are often associated with particular state programs. The authors explain how scaling procedures from item response theory lead to nonnormal distributions as well as unusual patterns of discreteness. The authors recommend that distributional descriptive statistics be calculated routinely to inform model selection for large-scale test score data, and they illustrate consequences of nonnormality using sensitivity studies that compare baseline results to those from normalized score scales.

RETRACTED: Flap side edge noise modeling and prediction

NASA Astrophysics Data System (ADS)

Guo, Yueping

2013-08-01

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).This article has been retracted at the request of the first author because of the overlap with previously published papers. The first author takes full responsibility and sincerely apologizes for the error made.This article has been retracted at the request of the Editor-in-Chief.The article duplicates significant parts of an earlier paper by the same author, published in AIAA (Y.P. Guo, Aircraft flap side edge noise modeling and prediction. American Institute of Aeronautics and Astronautics, (2011), 10.2514/6.2011-2731). Prior to republication, conference papers should be comprehensively extended, and re-use of any data should be appropriately cited. As such this article represents a severe abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

A view from Riggs: treatment resistance and patient authority-IX. Integrative psychodynamic treatment of psychotic disorders.

PubMed

Tillman, Jane G

2008-01-01

Psychotic spectrum disorders present treatment challenges for patients, families, and clinicians. This article addresses the history of the dualism in the field between biological and psychological approaches to mental disorders, and surveys the contemporary literature about the etiology and treatment of psychotic spectrum disorders. An integrative approach to treatment derived from work at Austen Riggs with previously treatment refractory patients with psychotic spectrum disorders is described that combines individual psycho- dynamic psychotherapy, psychopharmacology, family systems approaches, and intensive psychosocial engagement. Helping patients develop their own authority to join the treatment, use relationships for learning, and understand the meaning of their symptoms is central to the treatment at Austen Riggs. An extended case vignette of a patient diagnosed with a schizoaffective disorder is presented illustrating this integrative psychodynamic treatment approach.

Reasoning on Weighted Delegatable Authorizations

NASA Astrophysics Data System (ADS)

Ruan, Chun; Varadharajan, Vijay

This paper studies logic based methods for representing and evaluating complex access control policies needed by modern database applications. In our framework, authorization and delegation rules are specified in a Weighted Delegatable Authorization Program (WDAP) which is an extended logic program. We show how extended logic programs can be used to specify complex security policies which support weighted administrative privilege delegation, weighted positive and negative authorizations, and weighted authorization propagations. We also propose a conflict resolution method that enables flexible delegation control by considering priorities of authorization grantors and weights of authorizations. A number of rules are provided to achieve delegation depth control, conflict resolution, and authorization and delegation propagations.

Global Solutions for the zero-energy Novikov–Veselov equation by inverse scattering

NASA Astrophysics Data System (ADS)

Music, Michael; Perry, Peter

2018-07-01

Using the inverse scattering method, we construct global solutions to the Novikov–Veselov equation for real-valued decaying initial data q 0 with the property that the associated Schrödinger operator is nonnegative. Such initial data are either critical (an arbitrarily small perturbation of the potential makes the operator nonpositive) or subcritical (sufficiently small perturbations of the potential preserve non-negativity of the operator). Previously, Lassas, Mueller, Siltanen and Stahel proved global existence for critical potentials, also called potentials of conductivity type. We extend their results to include the much larger class of subcritical potentials. We show that the subcritical potentials form an open set and that the critical potentials form the nowhere dense boundary of this open set. Our analysis draws on previous work of the first author and on ideas of Grinevich and Manakov.

Pulsatile flow in ventricular catheters for hydrocephalus

NASA Astrophysics Data System (ADS)

Giménez, Á.; Galarza, M.; Thomale, U.; Schuhmann, M. U.; Valero, J.; Amigó, J. M.

2017-05-01

The obstruction of ventricular catheters (VCs) is a major problem in the standard treatment of hydrocephalus, the flow pattern of the cerebrospinal fluid (CSF) being one important factor thereof. As a first approach to this problem, some of the authors studied previously the CSF flow through VCs under time-independent boundary conditions by means of computational fluid dynamics in three-dimensional models. This allowed us to derive a few basic principles which led to designs with improved flow patterns regarding the obstruction problem. However, the flow of the CSF has actually a pulsatile nature because of the heart beating and blood flow. To address this fact, here we extend our previous computational study to models with oscillatory boundary conditions. The new results will be compared with the results for constant flows and discussed. It turns out that the corrections due to the pulsatility of the CSF are quantitatively small, which reinforces our previous findings and conclusions. This article is part of the themed issue `Mathematical methods in medicine: neuroscience, cardiology and pathology'.

The international Genome sample resource (IGSR): A worldwide collection of genome variation incorporating the 1000 Genomes Project data.

PubMed

Clarke, Laura; Fairley, Susan; Zheng-Bradley, Xiangqun; Streeter, Ian; Perry, Emily; Lowy, Ernesto; Tassé, Anne-Marie; Flicek, Paul

2017-01-04

The International Genome Sample Resource (IGSR; http://www.internationalgenome.org) expands in data type and population diversity the resources from the 1000 Genomes Project. IGSR represents the largest open collection of human variation data and provides easy access to these resources. IGSR was established in 2015 to maintain and extend the 1000 Genomes Project data, which has been widely used as a reference set of human variation and by researchers developing analysis methods. IGSR has mapped all of the 1000 Genomes sequence to the newest human reference (GRCh38), and will release updated variant calls to ensure maximal usefulness of the existing data. IGSR is collecting new structural variation data on the 1000 Genomes samples from long read sequencing and other technologies, and will collect relevant functional data into a single comprehensive resource. IGSR is extending coverage with new populations sequenced by collaborating groups. Here, we present the new data and analysis that IGSR has made available. We have also introduced a new data portal that increases discoverability of our data-previously only browseable through our FTP site-by focusing on particular samples, populations or data sets of interest. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

Time to Let Go of the Illusion that Psychotherapy Extends the Survival of Cancer Patients: Reply to Kraemer, Kuchler, and Spiegel (2009)

ERIC Educational Resources Information Center

Coyne, James C.; Thombs, Brett D.; Stefanek, Michael; Palmer, Steven C.

2009-01-01

Replies to comments from Kraemer, Kuchler, and Spiegel on the authors original article Psychotherapy and survival in cancer: The conflict between hope and evidence. The authors recently reviewed evidence related to the notion that psychotherapy extends survival in cancer patients (J. C. Coyne, M. Stefanek, & S. C. Palmer, 2007). The authors found…

Extended exome sequencing identifies BACH2 as a novel major risk locus for Addison's disease.

PubMed

Eriksson, D; Bianchi, M; Landegren, N; Nordin, J; Dalin, F; Mathioudaki, A; Eriksson, G N; Hultin-Rosenberg, L; Dahlqvist, J; Zetterqvist, H; Karlsson, Å; Hallgren, Å; Farias, F H G; Murén, E; Ahlgren, K M; Lobell, A; Andersson, G; Tandre, K; Dahlqvist, S R; Söderkvist, P; Rönnblom, L; Hulting, A-L; Wahlberg, J; Ekwall, O; Dahlqvist, P; Meadows, J R S; Bensing, S; Lindblad-Toh, K; Kämpe, O; Pielberg, G R

2016-12-01

Autoimmune disease is one of the leading causes of morbidity and mortality worldwide. In Addison's disease, the adrenal glands are targeted by destructive autoimmunity. Despite being the most common cause of primary adrenal failure, little is known about its aetiology. To understand the genetic background of Addison's disease, we utilized the extensively characterized patients of the Swedish Addison Registry. We developed an extended exome capture array comprising a selected set of 1853 genes and their potential regulatory elements, for the purpose of sequencing 479 patients with Addison's disease and 1394 controls. We identified BACH2 (rs62408233-A, OR = 2.01 (1.71-2.37), P = 1.66 × 10 -15 , MAF 0.46/0.29 in cases/controls) as a novel gene associated with Addison's disease development. We also confirmed the previously known associations with the HLA complex. Whilst BACH2 has been previously reported to associate with organ-specific autoimmune diseases co-inherited with Addison's disease, we have identified BACH2 as a major risk locus in Addison's disease, independent of concomitant autoimmune diseases. Our results may enable future research towards preventive disease treatment. © 2016 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.

Landscape predictors of pathogen prevalence and range contractions in US bumblebees.

PubMed

McArt, Scott H; Urbanowicz, Christine; McCoshum, Shaun; Irwin, Rebecca E; Adler, Lynn S

2017-11-29

Several species of bumblebees have recently experienced range contractions and possible extinctions. While threats to bees are numerous, few analyses have attempted to understand the relative importance of multiple stressors. Such analyses are critical for prioritizing conservation strategies. Here, we describe a landscape analysis of factors predicted to cause bumblebee declines in the USA. We quantified 24 habitat, land-use and pesticide usage variables across 284 sampling locations, assessing which variables predicted pathogen prevalence and range contractions via machine learning model selection techniques. We found that greater usage of the fungicide chlorothalonil was the best predictor of pathogen ( Nosema bombi ) prevalence in four declining species of bumblebees. Nosema bombi has previously been found in greater prevalence in some declining US bumblebee species compared to stable species. Greater usage of total fungicides was the strongest predictor of range contractions in declining species, with bumblebees in the northern USA experiencing greater likelihood of loss from previously occupied areas. These results extend several recent laboratory and semi-field studies that have found surprising links between fungicide exposure and bee health. Specifically, our data suggest landscape-scale connections between fungicide usage, pathogen prevalence and declines of threatened and endangered bumblebees. © 2017 The Author(s).

Extended Transsphenoidal Endoscopic Endonasal Surgery of Suprasellar Craniopharyngiomas.

PubMed

Fomichev, Dmitry; Kalinin, Pavel; Kutin, Maxim; Sharipov, Oleg

2016-10-01

The endoscopic extended transsphenoidal approach for suprasellar craniopharyngiomas may be a really alternative to the transcranial approach in many cases. The authors present their experience with this technique in 136 patients with craniopharyngiomas. From the past 7 years 204 patients with different purely supradiaphragmatic tumors underwent removal by extended endoscopic transsphenoidal transtuberculum transplanum approach. Most of the patients (136) had craniopharyngiomas (suprasellar, intra-extraventricular). The patients were analyzed according to age, sex, tumor size, growth and tumor structure, and clinical symptoms. Twenty-five patients had undergone a previous surgery. The mean follow-up was 42 months (range, 4-120 months). The operation is always performed with the bilateral endoscopic endonasal anterior extended transsphenoidal approach. A gross-total removal was completed in 72%. Improvement of vision or absence of visual deterioration after operation was observed in 89% of patients; 11% had worsening vision after surgery. Endocrine dysfunction did not improve after surgery, new hypotalamopituitary dysfunction (anterior pituitary dysfunction or diabetes insipidus) or worsening of it was observed in 42.6%. Other main complications included transient new mental disorder in 11%, temporary neurological postoperative deficits in 3.7%, bacterial meningitis in 16%, cerebrospinal fluid leaks in 8.8%. The recurrence rate was 20% and the lethality was 5.8%. Resection of suprasellar craniopharyngiomas using the extended endoscopic approach is a more effective and less traumatic technology, able to provide resection of the tumor along with high quality of life after surgery, and relatively rare postoperative complications and mortality. Copyright © 2016 Elsevier Inc. All rights reserved.

5 CFR 575.503 - Who may approve the payment of an extended assignment incentive?

Code of Federal Regulations, 2012 CFR

2012-01-01

... extended assignment incentive? 575.503 Section 575.503 Administrative Personnel OFFICE OF PERSONNEL... DIFFERENTIALS; AND EXTENDED ASSIGNMENT INCENTIVES Extended Assignment Incentives § 575.503 Who may approve the payment of an extended assignment incentive? An authorized agency official must review and approve the...

5 CFR 575.503 - Who may approve the payment of an extended assignment incentive?

Code of Federal Regulations, 2010 CFR

2010-01-01

... extended assignment incentive? 575.503 Section 575.503 Administrative Personnel OFFICE OF PERSONNEL... DIFFERENTIALS; AND EXTENDED ASSIGNMENT INCENTIVES Extended Assignment Incentives § 575.503 Who may approve the payment of an extended assignment incentive? An authorized agency official must review and approve the...

Efficient Authorization of Rich Presence Using Secure and Composed Web Services

NASA Astrophysics Data System (ADS)

Li, Li; Chou, Wu

This paper presents an extended Role-Based Access Control (RBAC) model for efficient authorization of rich presence using secure web services composed with an abstract presence data model. Following the information symmetry principle, the standard RBAC model is extended to support context sensitive social relations and cascaded authority. In conjunction with the extended RBAC model, we introduce an extensible presence architecture prototype using WS-Security and WS-Eventing to secure rich presence information exchanges based on PKI certificates. Applications and performance measurements of our presence system are presented to show that the proposed RBAC framework for presence and collaboration is well suited for real-time communication and collaboration.

Types and Influence of Social Support on School Engagement of Young Survivors of Leukemia.

PubMed

Tougas, Anne-Marie; Jutras, Sylvie; Bigras, Marc

2016-08-01

The present study aimed to describe and explore the influence of social support on the school engagement of young survivors of pediatric leukemia. Fifty-three young Quebecers, previously diagnosed and treated for leukemia, completed a questionnaire measuring their school engagement and participated in an interview focusing on the support offered by four groups of relations with regard to school: parents, siblings, friends, and other nonprofessional relations. The interview responses revealed that parents were perceived to be the primary source of informational and emotional support, with support also provided to a lesser extent by friends, siblings, and members of the extended family. Inferential analyses indicated that young survivors report a higher school engagement score when they perceive themselves as receiving support from a greater number of groups of relations, especially from friends or siblings. © The Author(s) 2016.

The effect of the length of to-be-remembered lists and intervening lists on free recall: a reexamination using overt rehearsal.

PubMed

Ward, Geoff; Tan, Lydia

2004-11-01

In 3 experiments, the authors investigated the effects of to-be-remembered (TBR) and intervening list length on free recall to determine whether selective rehearsal could explain the previous finding that recall was affected only by TBR list length. In Experiments 1 (covert rehearsal) and 2 (overt rehearsal), participants saw 5- and 20-word lists and had to recall the list prior to that last presented list. In Experiment 3, either 1 or 2 lists were presented, and recall of TBR list was postcued. Recall proportion decreased with increased TBR list length. Moreover, the authors found extended recency effects when recall was replotted by when words were last rehearsed (Experiments 2 and 3) and an effect of intervening list length when rehearsal was reduced (Experiment 3). ((c) 2004 APA, all rights reserved).

Ion exchange of several radionuclides on the hydrous crystalline silicotitanate, UOP IONSIV IE-911

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huckman, M.E.; Latheef, I.M.; Anthony, R.G.

1999-04-01

The crystalline silicotitanate, UOP IONSIV IE-911, is a proven material for removing radionuclides from a wide variety of waste streams. It is superior for removing several radionuclides from the highly alkaline solutions typical of DOE wastes. This laboratory previously developed an equilibrium model applicable to complex solutions for IE-910 (the power form of the granular IE-911), and more recently, the authors have developed several single component ion-exchange kinetic models for predicting column breakthrough curves and batch reactor concentration histories. In this paper, the authors model ion-exchange column performance using effective diffusivities determined from batch kinetic experiments. This technique is preferablemore » because the batch experiments are easier, faster, and cheaper to perform than column experiments. They also extend these ideas to multicomponent systems. Finally, they evaluate the ability of the equilibrium model to predict data for IE-911.« less

Early grade curriculum-based reading measures for students with intellectual disability.

PubMed

Hill, David R; Lemons, Christopher J

2015-12-01

The purpose of this study was to extend previous research on the use of curriculum-based measurement (CBM) for students with intellectual disability by having 19 special education teachers monitor weekly reading progress of 38 students with intellectual disability for approximately 15 weeks and examining whether students exhibited gains on the progress monitoring measures. In addition to the weekly CBM, teachers reported the type and duration of daily reading instruction. Data were analyzed to explore relationships between CBM performance and reading instruction. Our results indicate that teachers are capable of administering and scoring CBM on a weekly basis and that CBM does capture reading growth for some students with intellectual disability. Correlations between CBM performance and a teacher report of skills taught during reading instruction indicate that teachers may be differentiating instruction based on students' reading ability. Directions for future research as well as limitations of the study are discussed. © The Author(s) 2015.

Effects of nonverbal behavior on perceptions of a female employee's power bases.

PubMed

Aguinis, H; Henle, C A

2001-08-01

The authors extended a previous examination of the effects of nonverbal behavior on perceptions of a male employee's power bases (H. Aguinis, M. M. Simonsen, & C. A. Pierce, 1998) by examining the effects of nonverbal behavior on perceptions of a female employee's power bases. U.S. undergraduates read vignettes describing a female employee engaging in 3 types of nonverbal behavior (i.e., eye contact, facial expression, body posture) and rated their perceptions of the woman's power bases (i.e., reward, coercive, legitimate, referent, expert, credibility). As predicted, (a) direct eye contact increased perceptions of coercive power, and (b) a relaxed facial expression decreased perceptions of all 6 power bases. Also as predicted, the present results differed markedly from those of Aguinis et al. (1998) regarding a male employee. The authors discuss implications for theory, future research, and the advancement of female employees.

Facial asymmetry as an indicator of psychological, emotional, and physiological distress.

PubMed

Shackelford, T K; Larsen, R J

1997-02-01

Fluctuating asymmetry (FA) is deviation from bilateral symmetry in morphological traits with asymmetry values that are normally distributed with a mean of 0. FA is produced by genetic or environmental perturbations of developmental design and may play a role in human sexual selection. K. Grammer and R. Thornhill (1994) found that facial FA negatively covaries with observer ratings of attractiveness, dominance, sexiness, and health. Using self-reports, observer ratings, daily diary reports, and psychophysiological measures, the authors assessed the relationship between facial FA and health in 2 samples of undergraduates (N = 101). Results partially replicate and extend those of K. Grammer and R. Thornhill (1994) and suggest that facial FA may signal psychological, emotional, and physiological distress. Discussion integrates the authors' findings with previous research on FA and suggests future research needed to clarify the role of FA in human sexual selection.

Adhesion modulation using glue droplet spreading in spider capture silk.

PubMed

Amarpuri, Gaurav; Zhang, Ci; Blackledge, Todd A; Dhinojwala, Ali

2017-05-01

Orb web spiders use sticky capture spiral silk to retain prey in webs. Capture spiral silk is composed of an axial fibre of flagelliform silk covered with glue droplets that are arranged in a beads-on-a-string morphology that allows multiple droplets to simultaneously extend and resist pull off. Previous studies showed that the adhesion of capture silk is responsive to environmental humidity, increasing up to an optimum humidity that varied among different spider species. The maximum adhesion was hypothesized to occur when the viscoelasticity of the glue optimized contributions from glue spreading and bulk cohesion. In this study, we show how glue droplet shape during peeling contributes significantly to capture silk adhesion. Both overspreading and underspreading of glue droplets reduces adhesion through changes in crack propagation and failure regime. Understanding the mechanism of stimuli-responsive adhesion of spider capture silk will lead to new designs for smarter adhesives. © 2017 The Author(s).

C*-algebras associated with reversible extensions of logistic maps

NASA Astrophysics Data System (ADS)

Kwaśniewski, Bartosz K.

2012-10-01

The construction of reversible extensions of dynamical systems presented in a previous paper by the author and A.V. Lebedev is enhanced, so that it applies to arbitrary mappings (not necessarily with open range). It is based on calculating the maximal ideal space of C*-algebras that extends endomorphisms to partial automorphisms via partial isometric representations, and involves a new set of 'parameters' (the role of parameters is played by chosen sets or ideals). As model examples, we give a thorough description of reversible extensions of logistic maps and a classification of systems associated with compression of unitaries generating homeomorphisms of the circle. Bibliography: 34 titles.

Width effects in transonic flow over a rectangular cavity

DOE PAGES

Beresh, Steven J.; Wagner, Justin L.; Henfling, John F.; ...

2015-07-24

A previous experiment by the present authors studied the flow over a finite-width rectangular cavity at freestream Mach numbers 1.5–2.5. In addition, this investigation considered the influence of three-dimensional geometry that is not replicated by simplified cavities that extend across the entire wind-tunnel test section. The latter configurations have the attraction of easy optical access into the depths of the cavity, but they do not reproduce effects upon the turbulent structures and acoustic modes due to the length-to-width ratio, which is becoming recognized as an important parameter describing the nature of the flow within narrower cavities.

Recognition of the geologic framework of porphyry deposits on ERTS-1 imagery

NASA Technical Reports Server (NTRS)

Wilson, J. C. (Principal Investigator)

1973-01-01

The author has identified the following significant results. Photointerpretation methods have been most successfully applied in the less vegetated test sites where several previously unknown geologic features have been recognized and known ones extended. Northwest mid-Tertiary faults in the ELY, Nevada area are observed to offset north-trending ranges and abruptly terminate older Mesozoic structures. In the Ray, Arizona area the observed patterns of fault and fracture systems appear to be related to the locations of known porphyry copper deposits. In the Tanacross, Alaska area a number of regional circular features observed may represent near surface intrusions and, therefore, permissive environments for copper porphyries.

Solving Fluid Structure Interaction Problems with an Immersed Boundary Method

NASA Technical Reports Server (NTRS)

Barad, Michael F.; Brehm, Christoph; Kiris, Cetin C.

2016-01-01

An immersed boundary method for the compressible Navier-Stokes equations can be used for moving boundary problems as well as fully coupled fluid-structure interaction is presented. The underlying Cartesian immersed boundary method of the Launch Ascent and Vehicle Aerodynamics (LAVA) framework, based on the locally stabilized immersed boundary method previously presented by the authors, is extended to account for unsteady boundary motion and coupled to linear and geometrically nonlinear structural finite element solvers. The approach is validated for moving boundary problems with prescribed body motion and fully coupled fluid structure interaction problems. Keywords: Immersed Boundary Method, Higher-Order Finite Difference Method, Fluid Structure Interaction.

Owning the program technical baseline for future space systems acquisition: program technical baseline tracking tool

NASA Astrophysics Data System (ADS)

Nguyen, Tien M.; Guillen, Andy T.; Hant, James J.; Kizer, Justin R.; Min, Inki A.; Siedlak, Dennis J. L.; Yoh, James

2017-05-01

The U.S. Air Force (USAF) has recognized the needs for owning the program and technical knowledge within the Air Force concerning the systems being acquired to ensure success. This paper extends the previous work done by the authors [1-2] on the "Resilient Program Technical Baseline Framework for Future Space Systems" and "Portfolio Decision Support Tool (PDST)" to the development and implementation of the Program and Technical Baseline (PTB) Tracking Tool (PTBTL) for the DOD acquisition life cycle. The paper describes the "simplified" PTB tracking model with a focus on the preaward phases and discusses how to implement this model in PDST.

Security in MANETs using reputation-adjusted routing

NASA Astrophysics Data System (ADS)

Ondi, Attila; Hoffman, Katherine; Perez, Carlos; Ford, Richard; Carvalho, Marco; Allen, William

2009-04-01

Mobile Ad-Hoc Networks enable communication in various dynamic environments, including military combat operations. Their open and shared communication medium enables new forms of attack that are not applicable for traditional wired networks. Traditional security mechanisms and defense techniques are not prepared to cope with the new attacks and the lack of central authorities make identity verifications difficult. This work extends our previous work in the Biologically Inspired Tactical Security Infrastructure to provide a reputation-based weighing mechanism for linkstate routing protocols to protect the network from attackers that are corrupting legitimate network traffic. Our results indicate that the approach is successful in routing network traffic around compromised computers.

Timepiece: Extending and Enhancing Learning Time.

ERIC Educational Resources Information Center

Anderson, Lorin W., Ed.; Walberg, Herbert J., Ed.

This publication offers suggestions for making more productive use of time, a scarce and valued educational resource. The chapter authors, authorities on the use of educational time, write about how to extend and enhance learning time within and outside schools. In "Productive Use of Time," Herbert Walberg describes how learning time can be…

FPGA acceleration of rigid-molecule docking codes

PubMed Central

Sukhwani, B.; Herbordt, M.C.

2011-01-01

Modelling the interactions of biological molecules, or docking, is critical both to understanding basic life processes and to designing new drugs. The field programmable gate array (FPGA) based acceleration of a recently developed, complex, production docking code is described. The authors found that it is necessary to extend their previous three-dimensional (3D) correlation structure in several ways, most significantly to support simultaneous computation of several correlation functions. The result for small-molecule docking is a 100-fold speed-up of a section of the code that represents over 95% of the original run-time. An additional 2% is accelerated through a previously described method, yielding a total acceleration of 36× over a single core and 10× over a quad-core. This approach is found to be an ideal complement to graphics processing unit (GPU) based docking, which excels in the protein–protein domain. PMID:21857870

Use of the nonavalent HPV vaccine in individuals previously fully or partially vaccinated with bivalent or quadrivalent HPV vaccines.

PubMed

Van Damme, Pierre; Bonanni, Paolo; Bosch, F Xavier; Joura, Elmar; Kjaer, Susanne Krüger; Meijer, Chris J L M; Petry, Karl-Ulrich; Soubeyrand, Benoit; Verstraeten, Thomas; Stanley, Margaret

2016-02-03

With the availability of the nonavalent human papillomavirus (HPV) vaccine, vaccinees, parents and healthcare providers need guidance on how to complete an immunization course started with the bi- or quadrivalent vaccine and whether to revaccinate individuals who have completed a full immunization course with the bi- or quadrivalent vaccine. To answer these questions three parameters should be considered: age at the start of vaccination (9 to 14 years of age versus 15 years and older, the cut-off for 2 or 3 doses schedule), the number of doses already received and the time interval between doses. Based on a number of scenarios, we propose that the 9-valent vaccine can be used to complete an incomplete vaccination regimen or might be added to a previous completed schedule to extend protection. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Quaternionic (super) twistors extensions and general superspaces

NASA Astrophysics Data System (ADS)

Cirilo-Lombardo, Diego Julio; Pervushin, Victor N.

2017-09-01

In a attempt to treat a supergravity as a tensor representation, the four-dimensional N-extended quaternionic superspaces are constructed from the (diffeomorphyc) graded extension of the ordinary Penrose-twistor formulation, performed in a previous work of the authors [D. J. Cirilo-Lombardo and V. N. Pervushin, Int. J. Geom. Methods Mod. Phys., doi: http://dx.doi.org/10.1142/S0219887816501139.], with N = p + k. These quaternionic superspaces have 4 + k(N - k) even-quaternionic coordinates and 4N odd-quaternionic coordinates, where each coordinate is a quaternion composed by four ℂ-fields (bosons and fermions respectively). The fields content as the dimensionality (even and odd sectors) of these superspaces are given and exemplified by selected physical cases. In this case, the number of fields of the supergravity is determined by the number of components of the tensor representation of the four-dimensional N-extended quaternionic superspaces. The role of tensorial central charges for any N even USp(N) = Sp(N, ℍℂ) ∩ U(N, ℍℂ) is elucidated from this theoretical context.

Mathematics beliefs and achievement of elementary school students in Japan and the United States: results from the Third International Mathematics and Science Study.

PubMed

House, J Daniel

2006-03-01

Student self-beliefs are significantly related to several types of academic achievement. In addition, results from international assessments have indicated that students in Japan have typically scored above international averages (D. L. Kelly, I. V. S. Mullis, & M. O. Martin, 2000). In this study, the author examined relationships between mathematics beliefs and achievement of elementary school-aged students in the United States and Japan. The students had participated in the Third International Mathematics and Science Study (TIMSS; A. E. Beaton et al., 1996). The author examined several self-beliefs and used variance estimation techniques for complex sampling designs. The author identified a number of significant relationships between self-beliefs and mathematics achievement. Students who attributed success in mathematics to controllable factors (e.g., hard work, studying at home) showed higher test scores whereas students who attributed success in mathematics at school to external factors (e.g., good luck) tended to earn lower mathematics test scores. These results extend the findings of previous research results because the author examined large national samples of students in cross-cultural settings as part of a comprehensive international assessment.

78 FR 34245 - Miscellaneous Corrections

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-07

... intended to authorize the Secretary to extend the time for the Commission to rule on a petition for review... the authority of the Secretary to extend the time for the Commission to rule on a petition for review... time for the Commission to rule on a petition for review under Sec. 2.341; * * * * * PART 40--DOMESTIC...

Early history of extended irreversible thermodynamics (1953-1983): An exploration beyond local equilibrium and classical transport theory

NASA Astrophysics Data System (ADS)

Lebon, G.; Jou, D.

2015-06-01

This paper gives a historical account of the early years (1953-1983) of extended irreversible thermodynamics (EIT). The salient features of this formalism are to upgrade the thermodynamic fluxes of mass, momentum, energy, and others, to the status of independent variables, and to explore the consistency between generalized transport equations and a generalized version of the second law of thermodynamics. This requires going beyond classical irreversible thermodynamics by redefining entropy and entropy flux. EIT provides deeper foundations, closer relations with microscopic formalisms, a wider spectrum of applications, and a more exciting conceptual appeal to non-equilibrium thermodynamics. We first recall the historical contributions by Maxwell, Cattaneo, and Grad on generalized transport equations. A thermodynamic theory wide enough to cope with such transport equations was independently proposed between 1953 and 1983 by several authors, each emphasizing different kinds of problems. In 1983, the first international meeting on this theory took place in Bellaterra (Barcelona). It provided the opportunity for the various authors to meet together for the first time and to discuss the common points and the specific differences of their previous formulations. From then on, a large amount of applications and theoretical confirmations have emerged. From the historical point of view, the emergence of EIT has been an opportunity to revisit the foundations and to open new avenues in thermodynamics, one of the most classical and well consolidated physical theories.

Extending Miles & Snow's strategy choice typology to the German hospital sector.

PubMed

Helmig, Bernd; Hinz, Vera; Ingerfurth, Stefan

2014-12-01

Hospitals' strategy choices represent highly relevant factors that affect organizational performance and survival. This study assesses the differences among hospitals' strategic choices. This strategy definition and assessment reflects the typology proposed by Miles and Snow, who distinguish four strategy types: defender, analyzer, prospector, and reactor. Synthesis of empirical evidence from previous studies that have applied Miles and Snow's typology in the hospital sector using various methodological approaches and measures provides hints for industry-specific patterns and avenues for further research. Taking an extended view of strategic choice, the authors conduct an empirical survey of a sample of 178 German hospitals. The authors apply a multi-item measure of the Miles and Snow strategy types in the hospital sector and identify hybrid strategy types that deviate from the four strategy types defined by Miles and Snow. Overall, seven distinct strategy types emerge from this analysis. There exist three distinct hybrid types in particular. Strategy choice is systematically related to hospital size and teaching status but not to ownership and location. The significant variance in performance for the seven different strategy types justifies the distinction between them. The results support the idea of industry-specific strategy choices. Policy makers should analyze the structural context in which hospitals operate and intervene through political and regulatory means. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

First recognition of the genus Verneuilia Hall and Clarke (Brachiopoda, Spiriferida) from North America (west-central Alaska)

USGS Publications Warehouse

Blodgett, R.B.; Johnson, J.G.

1994-01-01

The brachiopod genus Verneuilia Hall and Clarke, 1893, is recognized for the first time in North America, where it is represented by a new species described here. V. langenstrasseni. This occurrence extends not only the geographic range of the genus, but also the lower age and stratigraphic limit into the Eifelian (early Middle Devonian). Previously, the oldest known species was the type, V. cheiropteryx d'Archiac and de Verneuil, 1842, from the Givetian (late Middle Devonian) of Germany. Internal structures of V. langenstrasseni n.sp. are similar to those of genera in the ambocoeliid subfamily Rhynchospiriferinae, providing the first good evidence of a systematic relationship. -Authors

Impedance approach to designing efficient vibration energy absorbers

NASA Astrophysics Data System (ADS)

Bobrovnitskii, Y. I.; Morozov, K. D.; Tomilina, T. M.

2017-03-01

The concept introduced previously by the authors on the best sound absorber having the maximum allowable efficiency in absorbing the energy of an incident sound field has been extended to arbitrary linear elastic media and structures. Analytic relations have been found for the input impedance characteristics that the best vibrational energy absorber should have. The implementation of these relations is the basis of the proposed impedance method of designing efficient vibration and noise absorbers. We present the results of a laboratory experiment that confirms the validity of the obtained theoretical relations, and we construct the simplest best vibration absorber. We also calculate the parameters and demonstrate the efficiency of a dynamic vibration absorber as the best absorber.

Production of ethanol from enzymatically hydrolyzed orange peel by the yeast Saccharomyces cerevisiae

DOE Office of Scientific and Technical Information (OSTI.GOV)

Grohmann, K.; Baldwin, E.A.; Buslig, B.S.

The authors extended their previous investigations of enzymatic hydrolysis of polysaccharides in orange peel by commercial cellulase and pectinase enzymes to higher, more practical concentrations of orange peel solids. High yields of saccharification could be maintained even at substrate concentrations as high as 22-23%, but the rates of solubilization and saccarification decreased 2-3-fold. They also tested the fermentability of these hydrolysates by the yeast Saccharomyces cerevisiae, which revealed the presence of inhibitory compounds. These compounds could be removed by the filtration of hydrolyzed peel. Successful fermentations of filtered hydrolysates were achieved after pH adjustment with calcium carbonate. 27 refs., 6more » figs., 1 tab.« less

Bulk ultrasonic NDE of metallic components at high temperature using magnetostrictive transducers

NASA Astrophysics Data System (ADS)

Ashish, Antony Jacob; Rajagopal, Prabhu; Balasubramaniam, Krishnan; Kumar, Anish; Rao, B. Purnachandra; Jayakumar, Tammana

2017-02-01

Online ultrasonic NDE at high-temperature is of much interest to the power, process and automotive industries in view of possible savings in downtime. This paper describes a novel approach to developing ultrasonic transducers capable of high-temperature in-situ operation using the principle of magnetostriction. Preliminary design from previous research by the authors [1] is extended for operation at 1 MHz, and at elevated temperatures by amorphous metallic strips as the magnetostrictive core. Ultrasonic signals in pulse-echo mode are experimentally obtained from the ultrasonic transducer thus developed, in a simulated high-temperature environment of 350 °C for 10 hours. Advantages and challenges for practical deployment of this approach are discussed.

Index of satisfaction in engineering courses in Portugal based on the students perspective

NASA Astrophysics Data System (ADS)

Oliveira, Raquel; Gonçalves, A. Manuela; Vasconcelos, Rosa M.

2016-06-01

In this work we describe and characterize the student's allocation satisfaction in the Portuguese public higher education system through the students' point of view, namely, in the academic engineering programs, extending previous studies of the author's team. We compare the ratio provided by the Portuguese Education Ministry through the Institutions' point of view, demand satisfaction index with the ratio proposed, applicant's satisfaction index, for the so called post-Bologna period. The data used in this paper covers the years from 2007 to 2013, provided by the Portuguese Education Institute. Mann-Whitney and Kruskal-Wallis tests were performed in order to assess whether there are significant differences between the ratios.

Paranoia and psychotic process: some clinical applications of projective identification in psychoanalytic psychotherapy.

PubMed

Sweet, Alistair D

2010-01-01

The concept of projective identification has, since its introduction by Melanie Klein over half a century ago, caused much controversy amongst psychoanalysts and psychotherapists. In this paper the author traces some of the key theoretical developments of the concept since its introduction in 1946, including: normal and pathological projective identification, aspects of symbolisation and projective identification as an intrapsychic mechanism. An extended case report of a patient in weekly psychoanalytic psychotherapy is offered in order to expand upon some of the theoretical ideas previously considered. Emphasis is placed on the patient's use of intrapsychic projective mechanisms and the emergence and mutation of such mechanisms in the therapeutic relationship.

5 CFR 575.306 - Authorizing a retention incentive.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Authorizing a retention incentive. 575... RECRUITMENT, RELOCATION, AND RETENTION INCENTIVES; SUPERVISORY DIFFERENTIALS; AND EXTENDED ASSIGNMENT INCENTIVES Retention Incentives § 575.306 Authorizing a retention incentive. (a) Authority of authorized...

Multilayer neural networks for reduced-rank approximation.

PubMed

Diamantaras, K I; Kung, S Y

1994-01-01

This paper is developed in two parts. First, the authors formulate the solution to the general reduced-rank linear approximation problem relaxing the invertibility assumption of the input autocorrelation matrix used by previous authors. The authors' treatment unifies linear regression, Wiener filtering, full rank approximation, auto-association networks, SVD and principal component analysis (PCA) as special cases. The authors' analysis also shows that two-layer linear neural networks with reduced number of hidden units, trained with the least-squares error criterion, produce weights that correspond to the generalized singular value decomposition of the input-teacher cross-correlation matrix and the input data matrix. As a corollary the linear two-layer backpropagation model with reduced hidden layer extracts an arbitrary linear combination of the generalized singular vector components. Second, the authors investigate artificial neural network models for the solution of the related generalized eigenvalue problem. By introducing and utilizing the extended concept of deflation (originally proposed for the standard eigenvalue problem) the authors are able to find that a sequential version of linear BP can extract the exact generalized eigenvector components. The advantage of this approach is that it's easier to update the model structure by adding one more unit or pruning one or more units when the application requires it. An alternative approach for extracting the exact components is to use a set of lateral connections among the hidden units trained in such a way as to enforce orthogonality among the upper- and lower-layer weights. The authors call this the lateral orthogonalization network (LON) and show via theoretical analysis-and verify via simulation-that the network extracts the desired components. The advantage of the LON-based model is that it can be applied in a parallel fashion so that the components are extracted concurrently. Finally, the authors show the application of their results to the solution of the identification problem of systems whose excitation has a non-invertible autocorrelation matrix. Previous identification methods usually rely on the invertibility assumption of the input autocorrelation, therefore they can not be applied to this case.

Review of extended producer responsibility: A case study approach.

PubMed

Gupt, Yamini; Sahay, Samraj

2015-07-01

Principles of extended producer responsibility have been the core of most of the recent policies and legislation dealing with the end-of-life management of recyclable goods. This article makes an exploratory review of 27 cases of extended producer responsibility from developed and developing economies with and without informal recycling, to ascertain the most important aspect of extended producer responsibility. A comparative analysis of the cases with respect to role of stakeholders in the upstream and downstream stages of the extended producer responsibility has been carried out. Further, the study uses exploratory factor analysis to determine the important aspects of the extended producer responsibility in practice using 13 variables identified from the review. Findings of the comparative analysis reveal that financial responsibility of the producers and separate collecting and recycling agencies contributed significantly to the success of the extended producer responsibility-based environmental policies. Regulatory provisions, take-back responsibility and financial flow come out to be the three most important aspects of the extended producer responsibility. Presence of informal sector had a negative impact on the regulatory provisions. The outcomes of this study could serve as a guideline for designing of effective extended producer responsibility-based policies. © The Author(s) 2015.

76 FR 36533 - Transcontinental Gas Pipe Line Company, LLC; Notice of Request Under Blanket Authorization

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

...-000, for authorization to abandon in place: (i) Approximately 8.45 mile, 12- inch pipeline extending from South Marsh Island Block 38 to South Marsh Island Block 23, (ii) approximately 0.455 mile, 12-inch pipeline extending from production platform B in South Marsh Island Block 33 to South Marsh Island Block 38...

77 FR 8901 - Notice of a Change in Status of an Extended Benefit (EB) Period for New Mexico

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-15

... Extended Benefit (EB) Period for New Mexico AGENCY: Employment and Training Administration, Labor. ACTION... State's EB status: The Federal authorization to have a three year look-back was recently extended to... governed by the Federal- State Extended Unemployment Compensation Act of 1970, as amended, and the...

Extended cognition in science communication.

PubMed

Ludwig, David

2014-11-01

The aim of this article is to propose a methodological externalism that takes knowledge about science to be partly constituted by the environment. My starting point is the debate about extended cognition in contemporary philosophy and cognitive science. Externalists claim that human cognition extends beyond the brain and can be partly constituted by external devices. First, I show that most studies of public knowledge about science are based on an internalist framework that excludes the environment we usually utilize to make sense of science and does not allow the possibility of extended knowledge. In a second step, I argue that science communication studies should adopt a methodological externalism and accept that knowledge about science can be partly realized by external information resources such as Wikipedia. © The Author(s) 2013.

Outcomes in patients with chronic kidney disease not on dialysis receiving extended dosing regimens of darbepoetin alfa: long-term results of the EXTEND observational cohort study.

PubMed

Galle, Jan-Christoph; Addison, Janet; Suranyi, Michael G; Claes, Kathleen; Di Giulio, Salvatore; Guerin, Alain; Herlitz, Hans; Kiss, István; Farouk, Mourad; Manamley, Nick; Wirnsberger, Gerhard; Winearls, Christopher

2016-12-01

Extended dosing of the erythropoiesis-stimulating agent (ESA) darbepoetin alfa (DA) once biweekly or monthly reduces anaemia treatment burden. This observational study assessed outcomes and dosing patterns in patients with chronic kidney disease not on dialysis (CKD-NoD) commencing extended dosing of DA. Adult CKD-NoD patients starting extended dosing of DA in Europe or Australia in June 2006 or later were followed up until December 2012. Outcomes included haemoglobin (Hb) concentration, ESA dosing, mortality rates and receipt of dialysis and renal transplantation. Subgroup analyses were conducted for selected outcomes. Of 6035 enrolled subjects, 5723 (94.8%) met analysis criteria; 1795 (29.7%) received dialysis and 238 (3.9%) underwent renal transplantation. Mean (standard deviation) Hb concentration at commencement of extended dosing was 11.0 (1.5) g/dL. Mean [95% confidence interval (CI)] Hb 12 months after commencement of extended dosing (primary outcome) was 11.6 g/dL (11.5, 11.6) overall and was similar across countries, with no differences between subjects previously treated with an ESA versus ESA-naïve subjects, subjects with versus without prior renal transplant or diabetics versus non-diabetics. Weekly ESA dose gradually decreased following commencement of extended DA dosing and was similar across subgroups. The decrease in weekly DA dose was accompanied by an increase in the proportion of patients receiving iron therapy. Hb concentrations declined following changes in ESA labels and treatment guidelines. The mortality rate (95% CI) was 7.06 (6.68, 7.46) deaths per 100 years of follow-up. Subjects alive at study end had stable Hb concentrations in the preceding year, while those who died had lower and declining Hb concentrations in their last year. Long-term, extended dosing of DA maintained Hb concentrations in patients already treated with an ESA and corrected and maintained Hb in ESA-naïve patients. © The Author 2016. Published by Oxford University Press on behalf of ERA-EDTA.

Extended Interneuronal Network of the Dentate Gyrus.

PubMed

Szabo, Gergely G; Du, Xi; Oijala, Mikko; Varga, Csaba; Parent, Jack M; Soltesz, Ivan

2017-08-08

Local interneurons control principal cells within individual brain areas, but anecdotal observations indicate that interneuronal axons sometimes extend beyond strict anatomical boundaries. Here, we use the case of the dentate gyrus (DG) to show that boundary-crossing interneurons with cell bodies in CA3 and CA1 constitute a numerically significant and diverse population that relays patterns of activity generated within the CA regions back to granule cells. These results reveal the existence of a sophisticated retrograde GABAergic circuit that fundamentally extends the canonical interneuronal network. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Aircraft dual-shaft jet engine with indirect action fuel flow controller

NASA Astrophysics Data System (ADS)

Tudosie, Alexandru-Nicolae

2017-06-01

The paper deals with an aircraft single-jet engine's control system, based on a fuel flow controller. Considering the engine as controlled object and its thrust the most important operation effect, from the multitude of engine's parameters only its rotational speed n is measurable and proportional to its thrust, so engine's speed has become the most important controlled parameter. Engine's control system is based on fuel injection Qi dosage, while the output is engine's speed n. Based on embedded system's main parts' mathematical models, the author has described the system by its block diagram with transfer functions; furthermore, some Simulink-Matlab simulations are performed, concerning embedded system quality (its output parameters time behavior) and, meanwhile, some conclusions concerning engine's parameters mutual influences are revealed. Quantitative determinations are based on author's previous research results and contributions, as well as on existing models (taken from technical literature). The method can be extended for any multi-spool engine, single- or twin-jet.

Dysfunctional overnight memory consolidation in ecstasy users.

PubMed

Smithies, Vanessa; Broadbear, Jillian; Verdejo-Garcia, Antonio; Conduit, Russell

2014-08-01

Sleep plays an important role in the consolidation and integration of memory in a process called overnight memory consolidation. Previous studies indicate that ecstasy users have marked and persistent neurocognitive and sleep-related impairments. We extend past research by examining overnight memory consolidation among regular ecstasy users (n=12) and drug naïve healthy controls (n=26). Memory recall of word pairs was evaluated before and after a period of sleep, with and without interference prior to testing. In addition, we assessed neurocognitive performances across tasks of learning, memory and executive functioning. Ecstasy users demonstrated impaired overnight memory consolidation, a finding that was more pronounced following associative interference. Additionally, ecstasy users demonstrated impairments on tasks recruiting frontostriatal and hippocampal neural circuitry, in the domains of proactive interference memory, long-term memory, encoding, working memory and complex planning. We suggest that ecstasy-associated dysfunction in fronto-temporal circuitry may underlie overnight consolidation memory impairments in regular ecstasy users. © The Author(s) 2014.

Ribosome protection by antibiotic resistance ATP-binding cassette protein.

PubMed

Su, Weixin; Kumar, Veerendra; Ding, Yichen; Ero, Rya; Serra, Aida; Lee, Benjamin Sian Teck; Wong, Andrew See Weng; Shi, Jian; Sze, Siu Kwan; Yang, Liang; Gao, Yong-Gui

2018-05-15

The ribosome is one of the richest targets for antibiotics. Unfortunately, antibiotic resistance is an urgent issue in clinical practice. Several ATP-binding cassette family proteins confer resistance to ribosome-targeting antibiotics through a yet unknown mechanism. Among them, MsrE has been implicated in macrolide resistance. Here, we report the cryo-EM structure of ATP form MsrE bound to the ribosome. Unlike previously characterized ribosomal protection proteins, MsrE is shown to bind to ribosomal exit site. Our structure reveals that the domain linker forms a unique needle-like arrangement with two crossed helices connected by an extended loop projecting into the peptidyl-transferase center and the nascent peptide exit tunnel, where numerous antibiotics bind. In combination with biochemical assays, our structure provides insight into how MsrE binding leads to conformational changes, which results in the release of the drug. This mechanism appears to be universal for the ABC-F type ribosome protection proteins. Copyright © 2018 the Author(s). Published by PNAS.

The effects of surfing and the natural environment on the well-being of combat veterans.

PubMed

Caddick, Nick; Smith, Brett; Phoenix, Cassandra

2015-01-01

Although researchers have identified the benefits of physical activity on well-being, there is little evidence concerning the effects of nature-based physical activity. We investigated the effect of one nature-based activity-surfing-on the well-being of combat veterans experiencing posttraumatic stress disorder (PTSD). We conducted interviews and participant observations with a group of combat veterans belonging to a United Kingdom-based veterans' surfing charity. Our primary analytical approach was dialogical narrative analysis. Based on our rigorous analysis and findings, we suggest that surfing facilitated a sense of respite from PTSD. Respite was a fully embodied feeling of release from suffering that was cultivated through surfing and shaped by the stories veterans told of their experiences. We significantly extend previous knowledge on physical activity, combat veterans, and PTSD by highlighting how nature-based physical activity, encapsulated in the conceptual notion of the "blue gym," can promote well-being among combat veterans. © The Author(s) 2014.

Perceived Social Support Trajectories and the All-Cause Mortality Risk of Older Mexican American Women and Men.

PubMed

Hill, Terrence D; Uchino, Bert N; Eckhardt, Jessica L; Angel, Jacqueline L

2016-04-01

Although numerous studies of non-Hispanic Whites and Blacks show that social integration and social support tend to favor longevity, it is unclear whether this general pattern extends to the Mexican American population. Building on previous research, we employed seven waves of data from the Hispanic Established Populations for the Epidemiologic Study of the Elderly to examine the association between perceived social support trajectories and the all-cause mortality risk of older Mexican Americans. Growth mixture estimates revealed three latent classes of support trajectories: high, moderate, and low. Cox regression estimates indicated that older Mexican American men in the low support trajectory tend to exhibit a higher mortality risk than their counterparts in the high support trajectory. Social support trajectories were unrelated to the mortality risk of older Mexican American women. A statistically significant interaction term confirmed that social support was more strongly associated with the mortality risk of men. © The Author(s) 2015.

Ultrastructural aspects of autoschizis: a new cancer cell death induced by the synergistic action of ascorbate/menadione on human bladder carcinoma cells.

PubMed

Gilloteaux, J; Jamison, J M; Arnold, D; Taper, H S; Summers, J L

2001-01-01

Scanning and transmission electron microscopy were employed to further characterize the cytotoxic effects of a ascorbic acid/menadione (or vitamin C/vitamin K3) combination on a human bladder carcinoma T24 cell line. Following 1-h treatment T24 cells display membrane and mitochondrial defects as well as excision of cytoplasmic fragments that contain no organelles. These continuous self-excisions reduce the cell size. Concomitant, nuclear changes, chromatin disassembly, nucleolar condensation and fragmentation, and decreased nuclear volume lead to cell death via a process similar to karyorrhexis and karyolysis. Because this cell death is achieved through a progressive loss of cytoplasm due to self-morsellation, the authors named this mode of cell death autoschizis (from the Greek autos, self, and schizein, to split, as defined in Scanning. 1998; 20: 564-575). This morphological characterization of autoschizic cell death confirms and extends the authors previous reports and demonstrates that this cell death is distinct from apoptosis.

Changing roles: the radiologist in management.

PubMed

Siegle, R L; Nelsen, L

1999-05-01

Radiologists have rarely had direct administrative control of the hospital departments in which they practice. Several years ago, the administration of the medical school at the University of Texas Health Science Center at San Antonio and its county-owned principal teaching hospital agreed to integrate the physician and administrative management of the radiology department in an attempt to improve operations and reduce expenses. This integration is a pilot plan that will eventually be extended to most departments. The authors have collected data that measure department function for the seven quarters of physician management and compared these data with those of the previous four quarters prior to physician management. There are substantial increases in department activity, together with reductions in expenses and waiting time for procedures. These changes have occurred while overall hospital activity has decreased. Bench-marking studies show favorable comparison with comparable radiology departments. Radiologists can have an important effect on department operations when given the responsibility and authority for managing these affairs.

[Low transverse laparotomy with rectus abdominus section in gynecology and obstetrics. Apropos of 1,000 cases].

PubMed

Querleu, D; Delahousse, G; Turpin, D; Leblanc, P; Debodinance, P; Boutteville, C; Meurette, J; Laurent, J C; Crépin, G

1987-11-01

The authors report 1,000 cases (357 cesarean sections, 230 hysterectomies for benign lesions, 157 conservative utero-adnexal procedures, 128 tubal plasties, 58 prolapse or incontinence procedures, 70 cancers) ,of laparotomies performed according to the technique described by Mouchel in 1980, i.e. strictly supra-pubic and transverse, from skin to peritoneum, including section of the rectus abdominis. This incision enables to perform in ideal technical conditions, with a minimal complication rate (3 hematomas, 2 incisional hernias for 1,000), and satisfactory esthetic results, almost all of the gynecological and obstetrical surgical procedures (90% of two among the authors' practice). The only contra-indications are, except for cases of previous median laparotomy, ovarian tumors. Neither the high risk of infection, nor obesity, extended hysterectomy, nor fetal distress, represent contra-indications, which is a definite advantage over the Pfannenstiel incision. As compared with the median incision which at some time offered similar results, the esthetics and mainly the strength of the abdominal wall are markedly superior.

Periostin Limits Tumor Response to VEGFA Inhibition.

PubMed

Keklikoglou, Ioanna; Kadioglu, Ece; Bissinger, Stefan; Langlois, Benoît; Bellotti, Axel; Orend, Gertraud; Ries, Carola H; De Palma, Michele

2018-03-06

Resistance to antiangiogenic drugs limits their applicability in cancer therapy. Here, we show that revascularization and progression of pancreatic neuroendocrine tumors (PNETs) under extended vascular-endothelial growth factor A (VEGFA) blockade are dependent on periostin (POSTN), a matricellular protein expressed by stromal cells. Genetic deletion of Postn in RIP1-Tag2 mice blunted tumor rebounds of M2-like macrophages and αSMA + stromal cells in response to prolonged VEGFA inhibition and suppressed PNET revascularization and progression on therapy. POSTN deficiency also impeded the upregulation of basic fibroblast growth factor (FGF2), an adaptive mechanism previously implicated in PNET evasion from antiangiogenic therapy. Higher POSTN expression correlated with markers of M2-like macrophages in human PNETs, and depleting macrophages with a colony-stimulating factor 1 receptor (CSF1R) antibody inhibited PNET revascularization and progression under VEGFA blockade despite continued POSTN production. These findings suggest a role for POSTN in orchestrating resistance to anti-VEGFA therapy in PNETs. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

Damaging de novo mutations diminish motor skills in children on the autism spectrum.

PubMed

Buja, Andreas; Volfovsky, Natalia; Krieger, Abba M; Lord, Catherine; Lash, Alex E; Wigler, Michael; Iossifov, Ivan

2018-02-20

In individuals with autism spectrum disorder (ASD), de novo mutations have previously been shown to be significantly correlated with lower IQ but not with the core characteristics of ASD: deficits in social communication and interaction and restricted interests and repetitive patterns of behavior. We extend these findings by demonstrating in the Simons Simplex Collection that damaging de novo mutations in ASD individuals are also significantly and convincingly correlated with measures of impaired motor skills. This correlation is not explained by a correlation between IQ and motor skills. We find that IQ and motor skills are distinctly associated with damaging mutations and, in particular, that motor skills are a more sensitive indicator of mutational severity than is IQ, as judged by mutational type and target gene. We use this finding to propose a combined classification of phenotypic severity: mild (little impairment of either), moderate (impairment mainly to motor skills), and severe (impairment of both IQ and motor skills). Copyright © 2018 the Author(s). Published by PNAS.

Extended Kinship in the United States: Competing Models and the Case of La Familia Chicana.

ERIC Educational Resources Information Center

Sena-Rivera, Jaime

1979-01-01

Extended kinship among Chicanos is explored through intensive open-ended interviews with four cases of three generations of Mexican-descent families. "La familia chicana" is posited as a modified extended or kin-integrated family extending over time and space from Mexico at the turn of the century to present day industrial America. (Author)

Generic Safety Requirements for Developing Safe Insulin Pump Software

PubMed Central

Zhang, Yi; Jetley, Raoul; Jones, Paul L; Ray, Arnab

2011-01-01

Background The authors previously introduced a highly abstract generic insulin infusion pump (GIIP) model that identified common features and hazards shared by most insulin pumps on the market. The aim of this article is to extend our previous work on the GIIP model by articulating safety requirements that address the identified GIIP hazards. These safety requirements can be validated by manufacturers, and may ultimately serve as a safety reference for insulin pump software. Together, these two publications can serve as a basis for discussing insulin pump safety in the diabetes community. Methods In our previous work, we established a generic insulin pump architecture that abstracts functions common to many insulin pumps currently on the market and near-future pump designs. We then carried out a preliminary hazard analysis based on this architecture that included consultations with many domain experts. Further consultation with domain experts resulted in the safety requirements used in the modeling work presented in this article. Results Generic safety requirements for the GIIP model are presented, as appropriate, in parameterized format to accommodate clinical practices or specific insulin pump criteria important to safe device performance. Conclusions We believe that there is considerable value in having the diabetes, academic, and manufacturing communities consider and discuss these generic safety requirements. We hope that the communities will extend and revise them, make them more representative and comprehensive, experiment with them, and use them as a means for assessing the safety of insulin pump software designs. One potential use of these requirements is to integrate them into model-based engineering (MBE) software development methods. We believe, based on our experiences, that implementing safety requirements using MBE methods holds promise in reducing design/implementation flaws in insulin pump development and evolutionary processes, therefore improving overall safety of insulin pump software. PMID:22226258

Exact and Approximate Statistical Inference for Nonlinear Regression and the Estimating Equation Approach.

PubMed

Demidenko, Eugene

2017-09-01

The exact density distribution of the nonlinear least squares estimator in the one-parameter regression model is derived in closed form and expressed through the cumulative distribution function of the standard normal variable. Several proposals to generalize this result are discussed. The exact density is extended to the estimating equation (EE) approach and the nonlinear regression with an arbitrary number of linear parameters and one intrinsically nonlinear parameter. For a very special nonlinear regression model, the derived density coincides with the distribution of the ratio of two normally distributed random variables previously obtained by Fieller (1932), unlike other approximations previously suggested by other authors. Approximations to the density of the EE estimators are discussed in the multivariate case. Numerical complications associated with the nonlinear least squares are illustrated, such as nonexistence and/or multiple solutions, as major factors contributing to poor density approximation. The nonlinear Markov-Gauss theorem is formulated based on the near exact EE density approximation.

The mind behind the message: advancing theory-of-mind scales for typically developing children, and those with deafness, autism, or Asperger syndrome.

PubMed

Peterson, Candida C; Wellman, Henry M; Slaughter, Virginia

2012-01-01

Children aged 3-12 years (n = 184) with typical development, deafness, autism, or Asperger syndrome took a series of theory-of-mind (ToM) tasks to confirm and extend previous developmental scaling evidence. A new sarcasm task, in the format of H. M. Wellman and D. Liu's (2004) 5-step ToM Scale, added a statistically reliable 6th step to the scale for all diagnostic groups. A key previous finding, divergence in task sequencing for children with autism, was confirmed. Comparisons among diagnostic groups, controlling age, and language ability, showed that typical developers mastered the 6 ToM steps ahead of each of the 3 disabled groups, with implications for ToM theories. The final (sarcasm) task challenged even nondisabled 9-year-olds, demonstrating the new scale's sensitivity to post-preschool ToM growth. © 2012 The Authors. Child Development © 2012 Society for Research in Child Development, Inc.

Auditory perception in the aging brain: the role of inhibition and facilitation in early processing.

PubMed

Stothart, George; Kazanina, Nina

2016-11-01

Aging affects the interplay between peripheral and cortical auditory processing. Previous studies have demonstrated that older adults are less able to regulate afferent sensory information and are more sensitive to distracting information. Using auditory event-related potentials we investigated the role of cortical inhibition on auditory and audiovisual processing in younger and older adults. Across puretone, auditory and audiovisual speech paradigms older adults showed a consistent pattern of inhibitory deficits, manifested as increased P50 and/or N1 amplitudes and an absent or significantly reduced N2. Older adults were still able to use congruent visual articulatory information to aid auditory processing but appeared to require greater neural effort to resolve conflicts generated by incongruent visual information. In combination, the results provide support for the Inhibitory Deficit Hypothesis of aging. They extend previous findings into the audiovisual domain and highlight older adults' ability to benefit from congruent visual information during speech processing. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Autonomic, subjective, and expressive responses to emotional films in older and younger Chinese Americans and European Americans.

PubMed

Tsai, J L; Levenson, R W; Carstensen, L L

2000-12-01

Previously, the authors found that during idiosyncratic emotional events (relived emotions, discussions about marital conflict), older European American adults demonstrated smaller changes in cardiovascular responding than their younger counterparts (R. W. Levenson, L. L. Carstensen, W. V. Friesen, & P. Ekman, 1991; R. W. Levenson, L. L. Carstensen, & J. M. Gottman, 1994). This study examined whether such differences held when the emotional events were standardized, and whether they extend to another cultural group. Forty-eight old (70-85 years) and 48 young (20-34 years) European Americans and Chinese Americans viewed sad and amusing film clips in the laboratory while their cardiovascular, subjective (online and retrospective), and behavioral responses were measured. Consistent with previous findings, older participants evidenced smaller changes in cardiovascular responding than did younger participants during the film clips. Consistent with earlier reports, old and young participants did not differ in most subjective and behavioral responses to the films. No cultural differences were found.

Whither cognitive bias modification research? Commentary on the special section articles.

PubMed

MacLeod, Colin; Koster, Ernst H W; Fox, Elaine

2009-02-01

This commentary reviews key theoretical, methodological, and clinical issues raised by recent research on cognitive bias modification (CBM). The authors identify the major ways in which the new work reported within this special section extends earlier CBM research. In particular, they note that it considers a wider range of participants, includes a greater diversity of symptoms measures, and targets for change a broader array of processing biases than previously has been the case. Furthermore, they point out that the present work develops and employs a more diverse arsenal of bias modification procedures, in some cases delivered across extended periods of time within naturalistic settings. They also draw attention to methodological limitations associated with the current studies, offering recommendations concerning how future CBM research might profitably build upon these exciting new directions while overcoming such limitations. Finally, they evaluate the theoretical and applied implications of the reported findings, discussing their capacity to illuminate the causal contributions made by cognitive bias to emotional vulnerability and their promise concerning the potential therapeutic value of CBM as a clinical tool.

Extending the Cortical Grasping Network: Pre-supplementary Motor Neuron Activity During Vision and Grasping of Objects.

PubMed

Lanzilotto, Marco; Livi, Alessandro; Maranesi, Monica; Gerbella, Marzio; Barz, Falk; Ruther, Patrick; Fogassi, Leonardo; Rizzolatti, Giacomo; Bonini, Luca

2016-12-01

Grasping relies on a network of parieto-frontal areas lying on the dorsolateral and dorsomedial parts of the hemispheres. However, the initiation and sequencing of voluntary actions also requires the contribution of mesial premotor regions, particularly the pre-supplementary motor area F6. We recorded 233 F6 neurons from 2 monkeys with chronic linear multishank neural probes during reaching-grasping visuomotor tasks. We showed that F6 neurons play a role in the control of forelimb movements and some of them (26%) exhibit visual and/or motor specificity for the target object. Interestingly, area F6 neurons form 2 functionally distinct populations, showing either visually-triggered or movement-related bursts of activity, in contrast to the sustained visual-to-motor activity displayed by ventral premotor area F5 neurons recorded in the same animals and with the same task during previous studies. These findings suggest that F6 plays a role in object grasping and extend existing models of the cortical grasping network. © The Author 2016. Published by Oxford University Press.

Frequency of Maternal Touch Predicts Resting Activity and Connectivity of the Developing Social Brain.

PubMed

Brauer, Jens; Xiao, Yaqiong; Poulain, Tanja; Friederici, Angela D; Schirmer, Annett

2016-08-01

Previous behavioral research points to a positive relationship between maternal touch and early social development. Here, we explored the brain correlates of this relationship. The frequency of maternal touch was recorded for 43 five-year-old children during a 10 min standardized play session. Additionally, all children completed a resting-state functional magnetic resonance imaging session. Investigating the default mode network revealed a positive relation between the frequency of maternal touch and activity in the right posterior superior temporal sulcus (pSTS) extending into the temporo-parietal junction. Using this effect as a seed in a functional connectivity analysis identified a network including extended bilateral regions along the temporal lobe, bilateral frontal cortex, and left insula. Compared with children with low maternal touch, children with high maternal touch showed additional connectivity with the right dorso-medial prefrontal cortex. Together these results support the notion that childhood tactile experiences shape the developing "social brain" with a particular emphasis on a network involved in mentalizing. © The Author 2016. Published by Oxford University Press.

Generation of phase II in vitro metabolites using homogenized horse liver.

PubMed

Wong, Jenny K Y; Chan, George H M; Leung, David K K; Tang, Francis P W; Wan, Terence S M

2016-02-01

The successful use of homogenized horse liver for the generation of phase I in vitro metabolites has been previously reported by the authors' laboratory. Prior to the use of homogenized liver, the authors' laboratory had been using mainly horse liver microsomes for carrying out equine in vitro metabolism studies. Homogenized horse liver has shown significant advantages over liver microsomes for in vitro metabolism studies as the procedures are much quicker and have higher capability for generating more in vitro metabolites. In this study, the use of homogenized liver has been extended to the generation of phase II in vitro metabolites (glucuronide and/or sulfate conjugates) using 17β-estradiol, morphine, and boldenone undecylenate as model substrates. It was observed that phase II metabolites could also be generated even without the addition of cofactors. To the authors' knowledge, this is the first report of the successful use of homogenized horse liver for the generation of phase II metabolites. It also demonstrates the ease with which both phase I and phase II metabolites can now be generated in vitro simply by using homogenized liver without the need for ultracentrifuges or tedious preparation steps. Copyright © 2015 John Wiley & Sons, Ltd.

Narp regulates long-term aversive effects of morphine withdrawal.

PubMed

Reti, Irving M; Crombag, Hans S; Takamiya, Kogo; Sutton, Jeffrey M; Guo, Ning; Dinenna, Megan L; Huganir, Richard L; Holland, Peter C; Baraban, Jay M

2008-08-01

Although long-lasting effects of drug withdrawal are thought to play a key role in motivating continued drug use, the mechanisms mediating this type of drug-induced plasticity are unclear. Because Narp is an immediate early gene product that is secreted at synaptic sites and binds to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, it has been implicated in mediating enduring forms of synaptic plasticity. In previous studies, the authors found that Narp is selectively induced by morphine withdrawal in the extended amygdala, a group of limbic nuclei that mediate aversive behavioral responses. Accordingly, in this study, the authors evaluate whether long-term aversive effects of morphine withdrawal are altered in Narp knockout (KO) mice. The authors found that acute physical signs of morphine withdrawal are unaffected by Narp deletion. However, Narp KO mice acquire and sustain more aversive responses to the environment conditioned with morphine withdrawal than do wild type (WT) controls. Paradoxically, Narp KO mice undergo accelerated extinction of this heightened aversive response. Taken together, these studies suggest that Narp modulates both acquisition and extinction of aversive responses to morphine withdrawal and, therefore, may regulate plasticity processes underlying drug addiction.

Conformal expansions and renormalons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rathsman, J.

2000-02-07

The coefficients in perturbative expansions in gauge theories are factorially increasing, predominantly due to renormalons. This type of factorial increase is not expected in conformal theories. In QCD conformal relations between observables can be defined in the presence of a perturbative infrared fixed-point. Using the Banks-Zaks expansion the authors study the effect of the large-order behavior of the perturbative series on the conformal coefficients. The authors find that in general these coefficients become factorially increasing. However, when the factorial behavior genuinely originates in a renormalon integral, as implied by a postulated skeleton expansion, it does not affect the conformal coefficients.more » As a consequence, the conformal coefficients will indeed be free of renormalon divergence, in accordance with previous observations concerning the smallness of these coefficients for specific observables. The authors further show that the correspondence of the BLM method with the skeleton expansion implies a unique scale-setting procedure. The BLM coefficients can be interpreted as the conformal coefficients in the series relating the fixed-point value of the observable with that of the skeleton effective charge. Through the skeleton expansion the relevance of renormalon-free conformal coefficients extends to real-world QCD.« less

Incivility in the workplace: incidence and impact.

PubMed

Cortina, L M; Magley, V J; Williams, J H; Langhout, R D

2001-01-01

This study extends the literature on interpersonal mistreatment in the workplace by examining the incidence, targets, instigators, and impact of incivility (e.g., disrespect, condescension, degradation). Data were collected from 1,180 public-sector employees, 71% of whom reported some experience of workplace incivility in the previous 5 years. As many as one third of the most powerful individuals within the organization instigated these uncivil acts. Although women endured greater frequencies of incivility than did men, both genders experienced similarly negative effects on job satisfaction, job withdrawal, and career salience. Uncivil workplace experiences were also associated with greater psychological distress; however, indices of psychological and physical health were relatively unaffected. The authors discuss these findings in the context of organizational and cognitive stress theories.

Fractal dimension of spatially extended systems

NASA Astrophysics Data System (ADS)

Torcini, A.; Politi, A.; Puccioni, G. P.; D'Alessandro, G.

1991-10-01

Properties of the invariant measure are numerically investigated in 1D chains of diffusively coupled maps. The coarse-grained fractal dimension is carefully computed in various embedding spaces, observing an extremely slow convergence towards the asymptotic value. This is in contrast with previous simulations, where the analysis of an insufficient number of points led the authors to underestimate the increase of fractal dimension with increasing the dimension of the embedding space. Orthogonal decomposition is also performed confirming that the slow convergence is intrinsically related to local nonlinear properties of the invariant measure. Finally, the Kaplan-Yorke conjecture is tested for short chains, showing that, despite the noninvertibility of the dynamical system, a good agreement is found between Lyapunov dimension and information dimension.

77 FR 3958 - Coordination of Federal Authorizations for Electric Transmission Facilities

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-26

... Coordination of Federal Authorizations for Electric Transmission Facilities AGENCY: Office of Electricity... coordination of Federal Authorizations for Electric Transmission Facilities has been extended until February 27... authorizations for proposed interstate electric transmission facilities pursuant to section 216(h) of the Federal...

Scheduling, revenue management, and fairness in an academic-hospital radiology division.

PubMed

Baum, Richard; Bertsimas, Dimitris; Kallus, Nathan

2014-10-01

Physician staff of academic hospitals today practice in several geographic locations including their main hospital. This is referred to as the extended campus. With extended campuses expanding, the growing complexity of a single division's schedule means that a naive approach to scheduling compromises revenue. Moreover, it may provide an unfair allocation of individual revenue, desirable or burdensome assignments, and the extent to which the preferences of each individual are met. This has adverse consequences on incentivization and employee satisfaction and is simply against business policy. We identify the daily scheduling of physicians in this context as an operational problem that incorporates scheduling, revenue management, and fairness. Noting previous success of operations research and optimization in each of these disciplines, we propose a simple unified optimization formulation of this scheduling problem using mixed-integer optimization. Through a study of implementing the approach at the Division of Angiography and Interventional Radiology at the Brigham and Women's Hospital, which is directed by one of the authors, we exemplify the flexibility of the model to adapt to specific applications, the tractability of solving the model in practical settings, and the significant impact of the approach, most notably in increasing revenue by 8.2% over previous operating revenue while adhering strictly to a codified fairness and objectivity. We found that the investment in implementing such a system is far outweighed by the large potential revenue increase and the other benefits outlined. Copyright © 2014 AUR. Published by Elsevier Inc. All rights reserved.

Gender differences in responses to cues presented in the natural environment of cigarette smokers.

PubMed

Wray, Jennifer M; Gray, Kevin M; McClure, Erin A; Carpenter, Matthew J; Tiffany, Stephen T; Saladin, Michael E

2015-04-01

Although the evidence is mixed, female smokers appear to have more difficulty quitting smoking than male smokers. Craving, stress, and negative affect have been hypothesized as potential factors underlying gender differences in quit rates. In the current study, the cue-reactivity paradigm was used to assess craving, stress, and negative affect in response to cues presented in the natural environment of cigarette smokers using ecological momentary assessment. Seventy-six daily smokers (42% female) responded to photographs (smoking, stress, and neutral) presented 4 times per day on an iPhone over the course of 2 weeks. Both smoking and stress cues elicited stronger cigarette craving and stress responses compared to neutral cues. Compared with males, females reported higher levels of post-stress cue craving, stress, and negative affect, but response to smoking cues did not differ by gender. Findings from this project were largely consistent with results from laboratory-based research and extend previous work by measuring response to cues in the natural environment of cigarette smokers. This study extends previous cue reactivity ecological momentary assessment research by using a new platform and by measuring response to stress cues outside of the laboratory. Findings from this project highlight the importance of addressing coping in response to stress cues in clinical settings, especially when working with female smokers. © The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Extended Treatment with Bupropion SR for Cigarette Smoking Cessation

ERIC Educational Resources Information Center

Killen, Joel D.; Fortmann, Stephen P.; Murphy, Greer M.; Hayward, Chris; Arredondo, Christina; Cromp, DeAnn; Celio, Maria; Abe, Laurie; Wang, Yun; Schatzberg, Alan F.

2006-01-01

The authors present results of a randomized clinical trial of the efficacy of extended treatment with bupropion SR in producing longer term cigarette smoking cessation. Adult smokers (N = 362) received open-label treatment (11 weeks) that combined relapse prevention training, bupropion SR, and nicotine patch followed by extended treatment (14…

The High Costs and Doubtful Efficacy of Extended Teacher-Preparation Programs: An Invitation to More Basic Reforms.

ERIC Educational Resources Information Center

Hawley, Willis D.

1987-01-01

Extended programs are likely to reduce the quality and quantity of teachers and probably will not improve teacher performance. Because the risks of extended programs are great and the benefits uncertain, other strategies for improving teacher education should be explored more aggressively. (Author/LHW)

Abscopal Effects With Hypofractionated Schedules Extending Into the Effector Phase of the Tumor-Specific T-Cell Response.

PubMed

Zhang, Xuanwei; Niedermann, Gabriele

2018-05-01

Hypofractionated radiation therapy (hRT) combined with immune checkpoint blockade can induce T-cell-mediated local and abscopal antitumor effects. We had previously observed peak levels of tumor-infiltrating lymphocytes (TILs) between days 5 and 8 after hRT. Because TILs are regarded as radiosensitive, hRT schedules extending into this period might be less immunogenic, prompting us to compare clinically relevant, short and extended schedules with equivalent biologically effective doses combined with anti-programmed cell death 1 (PD1) antibody treatment. In mice bearing 2 B16-CD133 melanoma tumors, the primary tumor was irradiated with 3 × 9.18 Gy in 3 or 5 days or with 5 × 6.43 Gy in 10 days; an anti-PD1 antibody was given weekly. The mice were monitored for tumor growth and survival. T-cell responses were determined on days 8 and 15 of treatment. The role of regional lymph nodes was studied by administering FTY720, which blocks lymph node egress of activated T cells. Tumor growth measurements after combination treatment using short or extended hRT and control treatment were also performed in the wild-type B16 melanoma and 4T1 breast carcinoma models. In the B16-CD133 model, growth inhibition of irradiated primary and nonirradiated secondary tumors and overall survival were similar with all 3 hRT/anti-PD1 combinations, superior to hRT and anti-PD1 monotherapy, and was strongly dependent on CD8 + T cells. TIL infiltration and local and systemic tumor-specific CD8 + T-cell responses were also similar, regardless of whether short or extended hRT was used. Administration of FTY720 accelerated growth of both primary and secondary tumors, strongly reduced their TIL infiltration, and increased tumor-specific CD8 + T cells in the lymph nodes draining the irradiated tumor. In the 4T1 model, local and abscopal tumor control was also similar, regardless of whether short or extended hRT was used, although the synergy between hRT and anti-PD1 was weaker. No synergies were found in the B16 wild-type model lacking an exogenous antigen. Our data suggest that combination therapy with hRT schedules extending into the period during which treatment-induced T cells infiltrate the irradiated tumor can provoke local and systemic antitumor effects similar to those with therapy using shorter schedules, if the regional lymph nodes supply sufficient tumor-specific T cells. This has implications for planning clinical RT/immune checkpoint blockade trials. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

Social foraging and individual consistency in following behaviour: testing the information centre hypothesis in free-ranging vultures.

PubMed

Harel, Roi; Spiegel, Orr; Getz, Wayne M; Nathan, Ran

2017-04-12

Uncertainties regarding food location and quality are among the greatest challenges faced by foragers and communal roosting may facilitate success through social foraging. The information centre hypothesis (ICH) suggests that uninformed individuals at shared roosts benefit from following informed individuals to previously visited resources. We tested several key prerequisites of the ICH in a social obligate scavenger, the Eurasian griffon vulture ( Gyps fulvus ), by tracking movements and behaviour of sympatric individuals over extended periods and across relatively large spatial scales, thereby precluding alternative explanations such as local enhancement. In agreement with the ICH, we found that 'informed' individuals returning to previously visited carcasses were followed by 'uninformed' vultures that consequently got access to these resources. When a dyad (two individuals that depart from the same roost within 2 min of each other) included an informed individual, they spent a higher proportion of the flight time close to each other at a shorter distance between them than otherwise. Although all individuals occasionally profited from following others, they differed in their tendencies to be informed or uninformed. This study provides evidence for 'following behaviour' in natural conditions and demonstrates differential roles and information states among foragers within a population. Moreover, demonstrating the possible reliance of vultures on following behaviour emphasizes that individuals in declining populations may suffer from reduced foraging efficiency. © 2017 The Author(s).

Gene cluster conservation provides insight into cercosporin biosynthesis and extends production to the genus Colletotrichum.

PubMed

de Jonge, Ronnie; Ebert, Malaika K; Huitt-Roehl, Callie R; Pal, Paramita; Suttle, Jeffrey C; Spanner, Rebecca E; Neubauer, Jonathan D; Jurick, Wayne M; Stott, Karina A; Secor, Gary A; Thomma, Bart P H J; Van de Peer, Yves; Townsend, Craig A; Bolton, Melvin D

2018-06-12

Species in the genus Cercospora cause economically devastating diseases in sugar beet, maize, rice, soy bean, and other major food crops. Here, we sequenced the genome of the sugar beet pathogen Cercospora beticola and found it encodes 63 putative secondary metabolite gene clusters, including the cercosporin toxin biosynthesis ( CTB ) cluster. We show that the CTB gene cluster has experienced multiple duplications and horizontal transfers across a spectrum of plant pathogenic fungi, including the wide-host range Colletotrichum genus as well as the rice pathogen Magnaporthe oryzae Although cercosporin biosynthesis has been thought to rely on an eight-gene CTB cluster, our phylogenomic analysis revealed gene collinearity adjacent to the established cluster in all CTB cluster-harboring species. We demonstrate that the CTB cluster is larger than previously recognized and includes cercosporin facilitator protein, previously shown to be involved with cercosporin autoresistance, and four additional genes required for cercosporin biosynthesis, including the final pathway enzymes that install the unusual cercosporin methylenedioxy bridge. Lastly, we demonstrate production of cercosporin by Colletotrichum fioriniae , the first known cercosporin producer within this agriculturally important genus. Thus, our results provide insight into the intricate evolution and biology of a toxin critical to agriculture and broaden the production of cercosporin to another fungal genus containing many plant pathogens of important crops worldwide. Copyright © 2018 the Author(s). Published by PNAS.

Impacts of extended working hours in logging

Treesearch

Dana Mitchell; Tom Gallagher

2008-01-01

Last year at the 2007 AIM in Minneapolis, MN, the authors presented the human factors impacts to consider when implementing extended working hours in the logging industry. In a continuation of this project, we have researched existing literature to identify possible actions that logging business owners can take to reduce the impact of extended working hours on their...

Extended access to methamphetamine self-administration up-regulates dopamine transporter levels 72 hours after withdrawal in rats.

PubMed

D'Arcy, Christina; Luevano, Joe E; Miranda-Arango, Manuel; Pipkin, Joseph A; Jackson, Jonathan A; Castañeda, Eddie; Gosselink, Kristin L; O'Dell, Laura E

2016-01-01

Previous studies have demonstrated that there are persistent changes in dopamine systems following withdrawal from methamphetamine (METH). This study examined changes in striatal dopamine transporter (DAT), tyrosine hydroxylase (TH) and dopamine receptor 2 (D2) 72 h after withdrawal from METH intravenous self- administration (IVSA). Rats were given limited (1h) or extended (6h) access to METH IVSA (0.05 mg/kg/0.1 ml infusion) for 22 days. Controls did not receive METH IVSA. The rats given extended access to IVSA displayed higher METH intake during the first hour of drug access compared to rats given limited access. Extended access to METH also produced a concomitant increase in striatal DAT levels relative to drug-naïve controls. There were no changes in TH or D2 levels across groups. Previous studies have reported a decrease in striatal DAT levels during protracted periods (>7 days) of withdrawal from METH IVSA. This study extends previous work by showing an increase in striatal DAT protein expression during an earlier time point of withdrawal from this drug. These results are an important step toward understanding the dynamic changes in dopamine systems that occur during different time points of withdrawal from METH IVSA. Copyright © 2015 Elsevier B.V. All rights reserved.

77 FR 40834 - Proposed Amendment of Class E Airspace; Dillon, MT

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-11

... further expand the previous proposed amendment of Class E airspace extending upward from 700 feet above... an amendment of Class E airspace extending upward from 700 feet above the surface. DATES: Comments... published a NPRM to modify Class E airspace, extending upward from 700 feet or more above the surface, at...

Production version of the extended NASA-Langley Vortex Lattice FORTRAN computer program. Volume 1: User's guide

NASA Technical Reports Server (NTRS)

Lamar, J. E.; Herbert, H. E.

1982-01-01

The latest production version, MARK IV, of the NASA-Langley vortex lattice computer program is summarized. All viable subcritical aerodynamic features of previous versions were retained. This version extends the previously documented program capabilities to four planforms, 400 panels, and enables the user to obtain vortex-flow aerodynamics on cambered planforms, flowfield properties off the configuration in attached flow, and planform longitudinal load distributions.

76 FR 19746 - Approval for Extension of Subzone Status and Manufacturing Authority; Foreign-Trade Subzone 169A...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-08

... Subzone Status and Manufacturing Authority; Foreign-Trade Subzone 169A; Aso LLC (Adhesive Bandages... indefinitely extend subzone status and manufacturing authority on behalf of Aso LLC (Aso) to perform adhesive... and manufacturing authority for the production of adhesive bandages under zone procedures within...

Enhancement of chest radiographs using eigenimage processing

NASA Astrophysics Data System (ADS)

Bones, Philip J.; Butler, Anthony P. H.; Hurrell, Michael

2006-08-01

Frontal chest radiographs ("chest X-rays") are routinely used by medical personnel to assess patients for a wide range of suspected disorders. Often large numbers of images need to be analyzed. Furthermore, at times the images need to analyzed ("reported") when no radiological expert is available. A system which enhances the images in such a way that abnormalities are more obvious is likely to reduce the chance that an abnormality goes unnoticed. The authors previously reported the use of principal components analysis to derive a basis set of eigenimages from a training set made up of images from normal subjects. The work is here extended to investigate how best to emphasize the abnormalities in chest radiographs. Results are also reported for various forms of image normalizing transformations used in performing the eigenimage processing.

Recovery of short-term memory and psychomotor speed but not postural stability with long-term sobriety in alcoholic women.

PubMed

Rosenbloom, Margaret J; Pfefferbaum, Adolf; Sullivan, Edith V

2004-07-01

The authors assessed effects of extended abstinence on cognitive and motor function deficits previously observed in a group of alcoholic women (n = 43) initially tested after 15 weeks of sobriety. Alcoholic women were retested 1 and 4 years later, and control women were retested 3 years later. At Year 1, 14 of 23 returners had maintained sobriety, but they did not perform significantly better than relapsers; the group as a whole continued to show deficits relative to age norms. By Year 4, 13 of 14 returners had maintained sobriety for more than 30 months; as a group, these women had returned to normal levels on tests of memory and psychomotor speed but remained impaired in standing balance.

Genetic and environmental contributions to pro-social attitudes: a twin study of social responsibility.

PubMed

Rushton, J Philippe

2004-12-22

Although 51 twin and adoption studies have been performed on the genetic architecture of antisocial behaviour, only four previous studies have examined a genetic contribution to pro-social behaviour. Earlier work by the author with the University of London Institute of Psychiatry Adult Twin Register found that genes contributed approximately half of the variance to measures of self-report altruism, empathy, nurturance and aggression, including acts of violence. The present study extends those results by using a 22-item Social Responsibility Questionnaire with 174 pairs of monozygotic twins and 148 pairs of dizygotic twins. Forty-two per cent of the reliable variance was due to the twins' genes, 23% to the twins' common environment and the remainder to the twins' non-shared environment.

The conformal transformation of an airfoil into a straight line and its application to the inverse problem of airfoil theory

NASA Technical Reports Server (NTRS)

Mutterperl, William

1944-01-01

A method of conformal transformation is developed that maps an airfoil into a straight line, the line being chosen as the extended chord line of the airfoil. The mapping is accomplished by operating directly with the airfoil ordinates. The absence of any preliminary transformation is found to shorten the work substantially over that of previous methods. Use is made of the superposition of solutions to obtain a rigorous counterpart of the approximate methods of thin-airfoils theory. The method is applied to the solution of the direct and inverse problems for arbitrary airfoils and pressure distributions. Numerical examples are given. Applications to more general types of regions, in particular to biplanes and to cascades of airfoils, are indicated. (author)

SeqSIMLA2_exact: simulate multiple disease sites in large pedigrees with given disease status for diseases with low prevalence.

PubMed

Yao, Po-Ju; Chung, Ren-Hua

2016-02-15

It is difficult for current simulation tools to simulate sequence data in a pre-specified pedigree structure and pre-specified affection status. Previously, we developed a flexible tool, SeqSIMLA2, for simulating sequence data in either unrelated case-control or family samples with different disease and quantitative trait models. Here we extended the tool to efficiently simulate sequences with multiple disease sites in large pedigrees with a given disease status for each pedigree member, assuming that the disease prevalence is low. SeqSIMLA2_exact is implemented with C++ and is available at http://seqsimla.sourceforge.net. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Genetic and environmental contributions to pro-social attitudes: a twin study of social responsibility.

PubMed Central

Rushton, J. Philippe

2004-01-01

Although 51 twin and adoption studies have been performed on the genetic architecture of antisocial behaviour, only four previous studies have examined a genetic contribution to pro-social behaviour. Earlier work by the author with the University of London Institute of Psychiatry Adult Twin Register found that genes contributed approximately half of the variance to measures of self-report altruism, empathy, nurturance and aggression, including acts of violence. The present study extends those results by using a 22-item Social Responsibility Questionnaire with 174 pairs of monozygotic twins and 148 pairs of dizygotic twins. Forty-two per cent of the reliable variance was due to the twins' genes, 23% to the twins' common environment and the remainder to the twins' non-shared environment. PMID:15615684

Software Support for Transiently Powered Computers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Van Der Woude, Joel Matthew

With the continued reduction in size and cost of computing, power becomes an increasingly heavy burden on system designers for embedded applications. While energy harvesting techniques are an increasingly desirable solution for many deeply embedded applications where size and lifetime are a priority, previous work has shown that energy harvesting provides insufficient power for long running computation. We present Ratchet, which to the authors knowledge is the first automatic, software-only checkpointing system for energy harvesting platforms. We show that Ratchet provides a means to extend computation across power cycles, consistent with those experienced by energy harvesting devices. We demonstrate themore » correctness of our system under frequent failures and show that it has an average overhead of 58.9% across a suite of benchmarks representative for embedded applications.« less

High-flux beam source of fast neutral helium.

PubMed

Fahey, D W; Schearer, L D; Parks, W F

1978-04-01

A high-flux beam source of fast neutral helium has been constructed by extending the designs of previous authors. The source is a dc or pulsed electric discharge in an expanding gas nozzle. The beam produced has a flux on the order of 10(15) atoms/s sr and a mean velocity on the order of 10(7) cm/s. The composition of the beam has been determined by the use of particle detectors and by the observation of the excitation of certain target gases. An upper bound of 3.7 x 10(-5) has been estimated for the He(2(3)S(1))/He((1)S(0))beam density ratio and a value of 0.2 found for the He(+)/He(1(1)S(0)) beam density ratio.

Kinematic activity of gray wolf (Canis lupus) sperm in different extenders, added before or after centrifugation.

PubMed

Christensen, Bruce W; Asa, Cheryl S; Wang, Chong; Bauman, Karen; Agnew, Mary K; Lorton, Steven P; Callahan, Margaret

2013-04-01

We evaluated two approaches to improving in vitro wolf sperm survival. Both approaches aimed to reduce the exposure of sperm to prostatic fluid resulting from electroejaculation: (1) use of extender formulations recently developed for the domestic dog (the most closely related domestic species); and (2) dilution of ejaculate shortly after semen collection. Three commercial extenders were compared with the TRIS-based extender we had previously used. We also compared the effects on motility of adding extender immediately after collection to our previous protocol in which extender was added after centrifugation. Both subjective and objective (computer-assisted semen analysis program) kinematic measurements were made. Relatively minor differences were noted (and not in total or progressive motility) between the centrifugation protocols. Two of the commercial extenders resulted in significant improvement in motility over the TRIS-based extender and one of the other commercial extenders at 8 hours after collection (mean ± SEM; total motility was 68.3 ± 4.0% and 70.0 ± 4.0% compared with 53.3 ± 4.0% and 55.0 ± 4.0%, respectively; progressive motility 58.6 ± 5.4% and 57.1 ± 5.4% compared with 32.8 ± 5.4% and 39.3 ± 5.4%; P < 0.05). We inferred that components in two of the commercial dog extenders might provide more protection for wolf sperm, prolonging their motility. Copyright © 2013 Elsevier Inc. All rights reserved.

Beyond the School Gates: Can Full Service and Extended Schools Overcome Disadvantage?

ERIC Educational Resources Information Center

Cummings, Colleen; Dyson, Alan; Todd, Liz

2011-01-01

This book, for the first time ever, critically examines the role of full service and extended schools. The authors draw on their extensive international evaluations of this radical new phenomenon to ask: (1) What do extended or full service schools hope to achieve, and why should services based on schools be any more effective than services…

School Leaders' Perceptions of the Impact of Extended Services on Families and Communities: The Case of One Local Authority

ERIC Educational Resources Information Center

Peterson, Andrew; Durrant, Ian

2013-01-01

The move in England towards extended services was a core part of the educational policy of successive Labour governments throughout the 2000s. Sitting alongside like-minded initiatives, school leaders were encouraged to envision, plan for and operate a range of activities and services aimed at deepening and extending schools' relationships with…

Ensuring Access and Inclusion for Marginalised Children in Extended Services: Identifying the Barriers and Promoting Choice

ERIC Educational Resources Information Center

Frost, Nick; Elmer, Sue; Best, Lesly; Mills, Sue

2010-01-01

This article by Nick Frost of Leeds Metropolitan University, Sue Elmer of Leeds Trinity University, and Lesly Best and Sue Mills, who are both Independent Researchers, looks at the experience of marginalised children in extended services. The authors conducted research into access to, and inclusion in, extended services based within schools and…

49 CFR 173.23 - Previously authorized packaging.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Previously authorized packaging. 173.23 Section... REQUIREMENTS FOR SHIPMENTS AND PACKAGINGS Preparation of Hazardous Materials for Transportation § 173.23 Previously authorized packaging. (a) When the regulations specify a packaging with a specification marking...

Personality disorders as maladaptive, extreme variants of normal personality: borderline personality disorder and neuroticism in a substance using sample.

PubMed

Samuel, Douglas B; Carroll, Kathleen M; Rounsaville, Bruce J; Ball, Samuel A

2013-10-01

Although the current diagnostic manual conceptualizes personality disorders (PDs) as categorical entities, an alternative perspective is that PDs represent maladaptive extreme versions of the same traits that describe normal personality. Existing evidence indicates that normal personality traits, such as those assessed by the five-factor model (FFM), share a common structure and obtain reasonably predictable correlations with the PDs. However, very little research has investigated whether PDs are more extreme than normal personality traits. Utilizing item-response theory analyses, the authors of the current study extend previous research to demonstrate that the diagnostic criterion for borderline personality disorder and FFM neuroticism could be fit along a single latent dimension. Furthermore, the authors' findings indicate that the borderline criteria assessed the shared latent trait at a level that was more extreme (d = 1.11) than FFM neuroticism. This finding provides further evidence for dimensional understanding of personality pathology and suggests that a trait model in DSM-5 should span normal and abnormal personality functioning, but focus on the extremes of these common traits.

A collision model for grain-resolving simulations of flows over dense, mobile, polydisperse granular sediment beds

DOE PAGES

Biegert, Edward; Vowinckel, Bernhard; Meiburg, Eckart

2017-03-21

We present a collision model for phase-resolved Direct Numerical Simulations of sediment transport that couple the fluid and particles by the Immersed Boundary Method. Typically, a contact model for these types of simulations comprises a lubrication force for particles in close proximity to another solid object, a normal contact force to prevent particles from overlapping, and a tangential contact force to account for friction. Our model extends the work of previous authors to improve upon the time integration scheme to obtain consistent results for particle-wall collisions. Furthermore, we account for polydisperse spherical particles and introduce new criteria to account formore » enduring contact, which occurs in many sediment transport situations. This is done without using arbitrary values for physically-defined parameters and by maintaining the full momentum balance of a particle in enduring contact. Lastly, we validate our model against several test cases for binary particle-wall collisions as well as the collective motion of a sediment bed sheared by a viscous flow, yielding satisfactory agreement with experimental data by various authors.« less

Immediate Extinction Attenuates Spontaneous Recovery and Reinstatement in a Passive Avoidance Paradigm.

PubMed

Briggs, James F; Fava, Devin A

2016-08-01

Recent research suggests that extinction occurring shortly after fear conditioning attenuates spontaneous recovery and reinstatement of fear. Two experiments investigated whether immediate extinction would prevent spontaneous recovery and reinstatement of fear using a passive avoidance paradigm. In Experiment 1, naive female adult rats (N = 40) received extinction training either immediately or 24 hours (delayed) after fear conditioning. Both extinction groups showed a significant reduction in fear at a 1-day test. At a 15-day test, spontaneous recovery was observed in the delayed extinction group while the immediate extinction group continued to show significant extinction. In Experiment 2, using a naive group of adult female rats (N = 16), the extinction result was replicated in both the immediate and delayed extinction groups at the 1-day interval. Reinstatement of fear, elicited by foot-shock in a neutral environment, was observed for the delayed group but not for the immediate group. By utilizing the passive-avoidance paradigm, these experiments replicate and extend previous findings that immediate extinction attenuates spontaneous recovery and reinstatement of fear. © The Author(s) 2016.

Shyness and cognitions: an examination of Turkish university students.

PubMed

Koydemir, Selda; Demir, Ayhan

2008-11-01

The authors aimed to examine the relation between shyness and dysfunctional relationship beliefs and to extend findings of previous studies to understand the role of fear of negative evaluation and self-esteem in shyness. Participants were 415 Turkish undergraduate students at Middle East Technical University. The participants completed Turkish versions of the J. M. Cheek and A. H. Buss (1981) Shyness Scale, the Interpersonal Cognitive Distortions Scale (Z. Hamamci & S. Büyükoztürk, 2004) the Brief Fear of Negative Evaluation Scale (M. R. Leary, 1983), and the M. Rosenberg (1965) Self-Esteem Scale. Bivariate correlations showed that shyness had a significant positive correlation with unrealistic relationship expectations and interpersonal rejection. Fear of negative evaluation and self-esteem also had significant relations to shyness. A stepwise regression analysis indicated that fear of negative evaluation, self-esteem, and interpersonal rejection were significant predictors of shyness, and self-esteem was the best predictor. These results provided evidence of the role of distorted relationship beliefs, approval concerns, and self-evaluations in shyness for Turkish university students. The authors discuss the findings in terms of relevant literature and cultural issues.

A collision model for grain-resolving simulations of flows over dense, mobile, polydisperse granular sediment beds

NASA Astrophysics Data System (ADS)

Biegert, Edward; Vowinckel, Bernhard; Meiburg, Eckart

2017-07-01

We present a collision model for phase-resolved Direct Numerical Simulations of sediment transport that couple the fluid and particles by the Immersed Boundary Method. Typically, a contact model for these types of simulations comprises a lubrication force for particles in close proximity to another solid object, a normal contact force to prevent particles from overlapping, and a tangential contact force to account for friction. Our model extends the work of previous authors to improve upon the time integration scheme to obtain consistent results for particle-wall collisions. Furthermore, we account for polydisperse spherical particles and introduce new criteria to account for enduring contact, which occurs in many sediment transport situations. This is done without using arbitrary values for physically-defined parameters and by maintaining the full momentum balance of a particle in enduring contact. We validate our model against several test cases for binary particle-wall collisions as well as the collective motion of a sediment bed sheared by a viscous flow, yielding satisfactory agreement with experimental data by various authors.

Is physical activity a cause of longevity? It is not as straightforward as some would believe. A critical analysis.

PubMed

Kujala, Urho M

2018-03-15

There are discrepant findings between (A) observational follow-ups and (B) interventional studies that investigate possible causal association between high physical activity and low mortality. Participation in vigorous physical activity at a specific time-point is an indicator of good fitness and health, and is associated with a reduced risk of death. However, neither randomised controlled trials nor experimental animal studies have provided conclusive evidence to show that physical activity started during adulthood extends lifespan. Consequently, the undisputed health-related benefits of exercise have yet to translate into any proven causal relationship with longevity. Physical activity improves fitness and physical function, and confers other health-related effects. These outcomes have a greater basis in evidence-based data than any claims of a reduced risk of death, especially when recommending physical activity for previously physically inactive middle-aged and elderly adults. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Maternal Inheritance of a Recessive RBP4 Defect in Canine Congenital Eye Disease.

PubMed

Kaukonen, Maria; Woods, Sean; Ahonen, Saija; Lemberg, Seppo; Hellman, Maarit; Hytönen, Marjo K; Permi, Perttu; Glaser, Tom; Lohi, Hannes

2018-05-29

Maternally skewed transmission of traits has been associated with genomic imprinting and oocyte-derived mRNA. We report canine congenital eye malformations, caused by an amino acid deletion (K12del) near the N terminus of retinol-binding protein (RBP4). The disease is only expressed when both dam and offspring are deletion homozygotes. RBP carries vitamin A (retinol) from hepatic stores to peripheral tissues, including the placenta and developing eye, where it is required to synthesize retinoic acid. Gestational vitamin A deficiency is a known risk factor for ocular birth defects. The K12del mutation disrupts RBP folding in vivo, decreasing its secretion from hepatocytes to serum. The maternal penetrance effect arises from an impairment in the sequential transfer of retinol across the placenta, via RBP encoded by maternal and fetal genomes. Our results demonstrate a mode of recessive maternal inheritance, with a physiological basis, and they extend previous observations on dominant-negative RBP4 alleles in humans. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

Dementia and well-being: A conceptual framework based on Tom Kitwood's model of needs.

PubMed

Kaufmann, Elke G; Engel, Sabine A

2016-07-01

The topic of well-being is becoming increasingly significant as a key outcome measure in dementia care. Previous work on personhood of individuals with dementia suggests that their subjective well-being can be described in terms of comfort, inclusion, identity, occupation and attachment The study aimed to examine Tom Kitwood's model of psychological needs and well-being in dementia based on the self-report of individuals with moderate or severe dementia and to differentiate and elaborate this model in the light of the empirical qualitative data. Nineteen inhabitants of a special long-term care unit were interviewed using a semi-structured interview. Data were analysed using content analysis. Thirty components within Kitwood's model have been identified. A conceptual framework of subjective well-being in dementia was developed based on a theoretical background. The study was able to find indications that Kitwood's model has empirical relevance. Nevertheless, it requires to be extended by the domain agency. Furthermore, the study suggests that individuals with dementia are important informants of their subjective well-being. © The Author(s) 2014.

A Linearized Model for Flicker and Contrast Thresholds at Various Retinal Illuminances

NASA Technical Reports Server (NTRS)

Ahumada, Albert; Watson, Andrew

2015-01-01

We previously proposed a flicker visibility metric for bright displays, based on psychophysical data collected at a high mean luminance. Here we extend the metric to other mean luminances. This extension relies on a linear relation between log sensitivity and critical fusion frequency, and a linear relation between critical fusion frequency and log retina lilluminance. Consistent with our previous metric, the extended flicker visibility metric is measured in just-noticeable differences (JNDs).

Combustion of Interacting Droplet Arrays in a Microgravity Environment

NASA Technical Reports Server (NTRS)

Dietrich, D. L.; Struk, P. M.; Ikegami, M.; Nagaishi, H.; Honma, S.; Ikeda, K.

2001-01-01

Investigations into droplet interactions date back to Rex et al. Annamalai and Ryan and Annamalai published extensive reviews of droplet array and cloud combustion studies. In the majority of the reviewed studies, the authors examined the change in the burning rate constant, k, (relative to that of the single droplet) that results from interactions. More recently, Niioka and co-workers have examined ignition and flame propagation along arrays of interacting droplets with the goal of relating these phenomena in this simplified geometry to the more practical spray configuration. Our work has focussed on droplet interactions under conditions where flame extinction occurs at a finite droplet diameter. In our previous work, we reported that in normal gravity, reduced pressure conditions, droplet interactions improved flame stability and extended flammability limits (by inference). In our recent work, we examine droplet interactions under conditions where the flame extinguishes at a finite droplet diameter in microgravity. The microgravity experiments were in the NASA GRC 2.2 and 5.2 second drop towers, and the JAMIC (Japan Microgravity Center) 10 second drop tower. We also present progress on a numerical model of single droplet combustion that is in the process of being extended to model a binary droplet array.

78 FR 79418 - Agency Information Collection Extension

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-30

...The Department of Energy (DOE), pursuant to the Paperwork Reduction Act of 1995), intends to extend for three years, an information collection request (OMB Control Number 1910-1700) with the Office of Management and Budget (OMB). The proposed voluntary collection will request that an individual or an authorized designee provide pertinent information for easy record retrieval allowing for increased efficiencies and quicker processing. Pertinent information includes the requester's name, shipping address, phone number, email address, previous work location, the action requested and any identifying data that will help locate the records (e.g., maiden name, occupational license number, time and place of employment). Comments are invited on: (a) whether the extended collection of information is necessary for the proper performance of the functions of the agency, including whether the information shall have practical utility; (b) the accuracy of the agency's estimate of the burden of the proposed collection of information, including the validity of the methodology and assumptions used; (c) ways to enhance the quality, utility, and clarity of the information to be collected; and, (d) ways to minimize the burden of the collection of information on respondents, including through the use of automated collection techniques or other forms of information technology.

A comparison of the pharmacokinetic profile of an ascending-dose, extended-regimen combined oral contraceptive to those of other extended regimens.

PubMed

Darwish, Mona; Bond, Mary; Ricciotti, Nancy; Hsieh, Jennifer; Fiedler-Kelly, Jill; Grasela, Thaddeus

2014-11-01

Quartette (levonorgestrel [LNG]/ethinyl estradiol [EE] and EE) is an ascending-dose, extended-regimen combined oral contraceptive (COC) that consists of a constant dose of LNG 150 µg on days 1 to 84 with EE 20 µg on days 1 to 42, 25 µg on days 43 to 63, 30 µg on days 64 to 84, and 10 µg of EE monotherapy on days 85 to 91. A population pharmacokinetic (PK) model for EE was developed using nonlinear mixed-effects modeling to characterize the PK profile of EE administered in Quartette and other extended-regimen LNG/EE COCs. Model-predicted plasma concentration-time profiles demonstrated a stepwise increase in systemic exposure to EE during the first 84 days of the cycle following each EE dose change. Lower concentrations of EE were noted during the final 7-day period of EE 10 µg. Gradual increases in EE seen with Quartette may decrease the incidence of unscheduled bleeding frequently observed during early cycles of extended-regimen COCs. © The Author(s) 2014.

The localization of a gene causing X-linked cleft palate and ankyloglossia (CPX) in an Icelandic kindred is between DXS326 and DXYS1X

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stainer, P.; Forbes, S.A.; Moore, G.

1993-09-01

The locus responsible for X-linked, nonsyndromic cleft palate and/or ankyloglossia (CPX) has previously been mapped to the proximal long arm of the human X chromosome between Xq21.31 and q21.33 in an Icelandic kindred. The authors have extended these studies by analyzing an additional 14 informative markers in the family as well as including several newly investigated family members. Recombination analysis indicates that the CPX locus is more proximal than previously thought, within the interval Xq21.1-q21.31. Two recombinants place DXYS1X as the distal flanking marker, while one recombinant defines DXS326 as the proximal flanking marker, an interval of less than 5more » cM. Each of the flanking markers recombines with the CPX locus, giving 2-point lod scores of Z[sub max] = 4.16 at [theta] = 0.08 (DXS326) and Z[sub max] = 5.80 at [theta] = 0.06 (DXYS1X). 35 refs., 3 figs., 2 tabs.« less

On the limits of probabilistic forecasting in nonlinear time series analysis II: Differential entropy.

PubMed

Amigó, José M; Hirata, Yoshito; Aihara, Kazuyuki

2017-08-01

In a previous paper, the authors studied the limits of probabilistic prediction in nonlinear time series analysis in a perfect model scenario, i.e., in the ideal case that the uncertainty of an otherwise deterministic model is due to only the finite precision of the observations. The model consisted of the symbolic dynamics of a measure-preserving transformation with respect to a finite partition of the state space, and the quality of the predictions was measured by the so-called ignorance score, which is a conditional entropy. In practice, though, partitions are dispensed with by considering numerical and experimental data to be continuous, which prompts us to trade off in this paper the Shannon entropy for the differential entropy. Despite technical differences, we show that the core of the previous results also hold in this extended scenario for sufficiently high precision. The corresponding imperfect model scenario will be revisited too because it is relevant for the applications. The theoretical part and its application to probabilistic forecasting are illustrated with numerical simulations and a new prediction algorithm.

Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome.

PubMed

Siegmund, Stephanie E; Yang, Hua; Sharma, Rohit; Javors, Martin; Skinner, Owen; Mootha, Vamsi; Hirano, Michio; Schon, Eric A

2017-12-01

Mitochondrial disorders affecting oxidative phosphorylation (OxPhos) are caused by mutations in both the nuclear and mitochondrial genomes. One promising candidate for treatment is the drug rapamycin, which has been shown to extend lifespan in multiple animal models, and which was previously shown to ameliorate mitochondrial disease in a knock-out mouse model lacking a nuclear-encoded gene specifying an OxPhos structural subunit (Ndufs4). In that model, relatively high-dose intraperitoneal rapamycin extended lifespan and improved markers of neurological disease, via an unknown mechanism. Here, we administered low-dose oral rapamycin to a knock-in (KI) mouse model of authentic mtDNA disease, specifically, progressive mtDNA depletion syndrome, resulting from a mutation in the mitochondrial nucleotide salvage enzyme thymidine kinase 2 (TK2). Importantly, low-dose oral rapamycin was sufficient to extend Tk2KI/KI mouse lifespan significantly, and did so in the absence of detectable improvements in mitochondrial dysfunction. We found no evidence that rapamycin increased survival by acting through canonical pathways, including mitochondrial autophagy. However, transcriptomics and metabolomics analyses uncovered systemic metabolic changes pointing to a potential 'rapamycin metabolic signature.' These changes also implied that rapamycin may have enabled the Tk2KI/KI mice to utilize alternative energy reserves, and possibly triggered indirect signaling events that modified mortality through developmental reprogramming. From a therapeutic standpoint, our results support the possibility that low-dose rapamycin, while not targeting the underlying mtDNA defect, could represent a crucial therapy for the treatment of mtDNA-driven, and some nuclear DNA-driven, mitochondrial diseases. © The Author 2017. Published by Oxford University Press.

Resource limitation and responses to rivals in males of the fruit fly Drosophila melanogaster.

PubMed

Mason, J S; Rostant, W G; Chapman, T

2016-10-01

Diet has a profound direct and indirect effect on reproductive success in both sexes. Variation in diet quality and quantity can significantly alter the capacity of females to lay eggs and of males to deliver courtship. Here, we tested the effect of dietary resource limitation on the ability of male Drosophila melanogaster to respond adaptively to rivals by extending their mating duration. Previous work carried out under ad libitum diet conditions showed that males exposed to rivals prior to mating significantly extend mating duration, transfer more ejaculate proteins and achieve higher reproductive success. Such adaptive responses are predicted to occur because male ejaculate production may be limited. Hence, ejaculate resources require allocation across different reproductive bouts, to balance current vs. future reproductive success. However, when males suffer dietary limitation, and potentially have fewer reproductive resources to apportion, we expect adaptive allocation of responses to rivals to be minimized. We tested this prediction and found that males held on agar-only diets for 5-7 days lost the ability to extend mating following exposure to rivals. Interestingly, extended mating was retained in males held on low yeast/sugar: no sugar/yeast diet treatments, but was mostly lost when males were maintained on 'imbalanced' diets in which there was high yeast: no sugar and vice versa. Overall, the results show that males exhibit adaptive responses to rivals according to the degree of dietary resource limitation and to the ratio of individual diet components. © 2016 The Authors. Journal of Evolutionary Biology published by John Wiley & Sons Ltd on behalf of European Society for Evolutionary Biology.

Leveraging Independent Management and Chief Engineer Hierarchy: Vertically and Horizontally-Derived Technical Authority Value

NASA Technical Reports Server (NTRS)

Barley, Bryan; Newhouse, Marilyn

2012-01-01

In the development of complex spacecraft missions, project management authority is usually extended hierarchically from NASA's highest agency levels down to the implementing institution's project team level, through both the center and the program. In parallel with management authority, NASA utilizes a complementary, but independent, hierarchy of technical authority (TA) that extends from the agency level to the project, again, through both the center and the program. The chief engineers (CEs) who serve in this technical authority capacity oversee and report on the technical status and ensure sound engineering practices, controls, and management of the projects and programs. At the lowest level, implementing institutions assign project CEs to technically engage projects, lead development teams, and ensure sound technical principles, processes, and issue resolution. At the middle level, programs and centers independently use CEs to ensure the technical success of their projects and programs. At the agency level, NASA's mission directorate CEs maintain technical cognizance over every program and project in their directorate and advise directorate management on the technical, cost, schedule, and programmatic health of each. As part of this vertically-extended CE team, a program level CE manages a continually varying balance between penetration depth and breadth across his or her assigned missions. Teamwork issues and information integration become critical for management at all levels to ensure value-added use of both the synergy available between CEs at the various agency levels, and the independence of the technical authority at each organization.

Another Simple yet Effective Best Practice for Increasing Enrollments at an Extended Campus

ERIC Educational Resources Information Center

Christensen, Steven S.; Howell, Scott L.; Hall, C. Giles

2016-01-01

This article is a follow-up to a previous article, "Six Ways to Increase Enrollments at an Extended Campus," published in this journal (vol. 17, no. 4, winter 2015), wherein a seventh best practice to increase course offerings and increase enrollments at an extended campus is presented. This best practice seeks to identify those areas of…

Progress connecting multi-disciplinary geoscience communities through the VIVO semantic web application

NASA Astrophysics Data System (ADS)

Gross, M. B.; Mayernik, M. S.; Rowan, L. R.; Khan, H.; Boler, F. M.; Maull, K. E.; Stott, D.; Williams, S.; Corson-Rikert, J.; Johns, E. M.; Daniels, M. D.; Krafft, D. B.

2015-12-01

UNAVCO, UCAR, and Cornell University are working together to leverage semantic web technologies to enable discovery of people, datasets, publications and other research products, as well as the connections between them. The EarthCollab project, an EarthCube Building Block, is enhancing an existing open-source semantic web application, VIVO, to address connectivity gaps across distributed networks of researchers and resources related to the following two geoscience-based communities: (1) the Bering Sea Project, an interdisciplinary field program whose data archive is hosted by NCAR's Earth Observing Laboratory (EOL), and (2) UNAVCO, a geodetic facility and consortium that supports diverse research projects informed by geodesy. People, publications, datasets and grant information have been mapped to an extended version of the VIVO-ISF ontology and ingested into VIVO's database. Data is ingested using a custom set of scripts that include the ability to perform basic automated and curated disambiguation. VIVO can display a page for every object ingested, including connections to other objects in the VIVO database. A dataset page, for example, includes the dataset type, time interval, DOI, related publications, and authors. The dataset type field provides a connection to all other datasets of the same type. The author's page will show, among other information, related datasets and co-authors. Information previously spread across several unconnected databases is now stored in a single location. In addition to VIVO's default display, the new database can also be queried using SPARQL, a query language for semantic data. EarthCollab will also extend the VIVO web application. One such extension is the ability to cross-link separate VIVO instances across institutions, allowing local display of externally curated information. For example, Cornell's VIVO faculty pages will display UNAVCO's dataset information and UNAVCO's VIVO will display Cornell faculty member contact and position information. Additional extensions, including enhanced geospatial capabilities, will be developed following task-centered usability testing.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cabello, Adan

We introduce an extended version of a previous all-versus-nothing proof of impossibility of Einstein-Podolsky-Rosen's local elements of reality for two photons entangled both in polarization and path degrees of freedom (A. Cabello, quant-ph/0507259), which leads to a Bell's inequality where the classical bound is 8 and the quantum prediction is 16. A simple estimation of the detection efficiency required to close the detection loophole using this extended version gives {eta}>0.69. This efficiency is lower than that required for previous proposals.

76 FR 35348 - Delegation of Authority to the Director of Its Division of Enforcement

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

... delegate authority to the Director of the Division of Enforcement (``Division'') to issue witness immunity... the authority to submit witness immunity requests to the Department of Justice, in connection with... evaluate whether to extend the delegation to issue immunity orders. The Commission finds, in accordance...

Multimodal Self-Authoring across Bi/Multilingual Educator and Student Learning Spaces

ERIC Educational Resources Information Center

Valdez, Verónica E.; Omerbašic, Delila

2015-01-01

Drawing on sociocultural perspectives, this article illustrates the potential for extending figured worlds through cultural artifacts. Using thematic and multimodal analysis, the authors first compare how spaces of authoring were produced in two professional development settings: Proyecto Bilingüe and Critical Education Studies. Following one…

Ontology-Based Multimedia Authoring Tool for Adaptive E-Learning

ERIC Educational Resources Information Center

Deng, Lawrence Y.; Keh, Huan-Chao; Liu, Yi-Jen

2010-01-01

More video streaming technologies supporting distance learning systems are becoming popular among distributed network environments. In this paper, the authors develop a multimedia authoring tool for adaptive e-learning by using characterization of extended media streaming technologies. The distributed approach is based on an ontology-based model.…

Decline of traditional family system and reproductive behaviour in rural Bangladesh.

PubMed

Sarker, P C

1993-01-01

This paper is based on data taken from the study entitled Social Structure and Fertility Behavior in a Rural Community of Bangladesh. The field-work was carried out during 1985-86 in Kamnagar, a village in the north-eastern corner of Rajshahi metropolitan city, with a total population of 884. 54.4% of the villagers had no education. Basic information was collected from every household by questionnaires interviewing the head of the household. In the 2nd phase questionnaires were administered to 140 eligible husbands and 140 wives separately to collect information on fertility behavior. 56.8% of the families were nuclear. 12.1% of the families were supplementary nuclear, with parents and their unmarried children including 1 or more additional members. 24.9% of the families were joint, in which related males belonging to 2 or 3 generations lived together with their dependents. 6.2% of the families were extended. As far as the authority structure was concerned, 68.1% of the families were patriarchal, 9.9% of the families were matriarchal, and 22% of the families were egalitarian. The egalitarian authority system is increasing with the spread of female literacy, economic activities outside the home, and women's mobility. Couples in nuclear families are more free to decide on the number of children, birth spacing, and adoption of contraception than those in joint, extended, and supplementary nuclear families with patriarchal and matriarchal authority structures. In nuclear families with an egalitarian authority structure, husband-wife communication can help decide about the number of children wanted, the acceptance of contraceptives, and child spacing. Nuclear families favor lower fertility than supplementary nuclear, joint, and extended families with a patriarchal or matriarchal authority structure. The number of traditional joint and extended families is on the decline with the trend to nuclear families as a result of the increasing landlessness in rural Bangladesh. The authority structure of the family is also changing from patriarchal or matriarchal to egalitarian.

Counseling and Values in a Time Perspective

ERIC Educational Resources Information Center

Smith, Darrell; Peterson, James A.

1977-01-01

Smith and Peterson answer the question, "What are the common values and ethics that influence our practice?" Their searching analysis extends for beyond professional beliefs and extends into the influence of issues such as the space race, sexism, race relations, Viet Nam, and Watergate. (Author)

Extended Thermodynamics: a Theory of Symmetric Hyperbolic Field Equations

NASA Astrophysics Data System (ADS)

Müller, Ingo

2008-12-01

Extended thermodynamics is based on a set of equations of balance which are supplemented by local and instantaneous constitutive equations so that the field equations are quasi-linear first order differential equations. If the constitutive functions are subject to the requirements of the entropy principle, one may write them in symmetric hyperbolic form by a suitable choice of fields. The kinetic theory of gases, or the moment theories based on the Boltzmann equation provide an explicit example for extended thermodynamics. The theory proves its usefulness and practicality in the successful treatment of light scattering in rarefied gases. This presentation is based upon the book [1] of which the author of this paper is a co-author. For more details about the motivation and exploitation of the basic principles the interested reader is referred to that reference. It would seem that extended thermodynamics is worthy of the attention of mathematicians. It may offer them a non-trivial field of study concerning hyperbolic equations, if ever they get tired of the Burgers equation. Physicists may prefer to appreciate the success of extended thermodynamics in light scattering and to work on the open problems concerning the modification of the Navier-Stokes-Fourier theory in rarefied gases as predicted by extended thermodynamics of 13, 14, and more moments.

The effects of cultural values on mental health among the Taiwanese people: mediating of attitudes toward emotional expression.

PubMed

Chu, Li-Chuan

2015-03-01

Empirical evidence has demonstrated that an individual's cultural values can influence his or her mental health. This study extends previous research by proposing and testing a model that examines mediating processes underlying the relationship between individuals' cultural values and their mental health. This 2-stage study used data collected from 208 (at time 1) and 159 (at time 2) full-time staff employed by private enterprises in Taiwan. The author tested hypotheses through the use of hierarchical multiple regression. The results showed that under horizontal individualism and vertical collectivism, the predictors of negative mental health (ie, somatic symptoms, anxiety and insomnia, social dysfunction and/or severe depression) were partially and almost completely achieved through the mediating effect of the negative attitudes toward emotional expression. © 2012 APJPH.

Eighteenth annual report of the United States Geological Survey to the Secretary of the Interior, 1896-1897: Part IV - Hydrography

USGS Publications Warehouse

Davis, Arthur Powell; Leverett, Frank; Darton, N.H.; Schuyler, J.D.

1897-01-01

The completion of this volume marks the revival of extended systematic investigation of the hydrography of the United State. This book is, in effect, the ninth annual report of what has been known as the Irrigation Survey. Its preparation and publication has been made possible by the act of June 11, 1896 (Stat. L., vol. 29, p. 436), which enlarged the scope of the work and authorized the preparation of reports upon the best methods of utilizing the water resources of arid and semiarid sections. For some years before this date the sums available for hydrographic work were so small that it was practicable merely to continue observations at previously established stations, compute discharges, and compile for publication the data accumulated in the office.

Fertility, Human Capital, and Economic Growth over the Demographic Transition

PubMed Central

Mason, Andrew

2009-01-01

Do low fertility and population aging lead to economic decline if couples have fewer children, but invest more in each child? By addressing this question, this article extends previous work in which the authors show that population aging leads to an increased demand for wealth that can, under some conditions, lead to increased capital per worker and higher per capita consumption. This article is based on an overlapping generations (OLG) model which highlights the quantity–quality tradeoff and the links between human capital investment and economic growth. It incorporates new national level estimates of human capital investment produced by the National Transfer Accounts project. Simulation analysis is employed to show that, even in the absence of the capital dilution effect, low fertility leads to higher per capita consumption through human capital accumulation, given plausible model parameters. PMID:20495605

Outgroup helping as a tool to communicate ingroup warmth.

PubMed

van Leeuwen, Esther; Täuber, Susanne

2012-06-01

The authors extend previous research on the effects of metastereotype activation on outgroup helping by examining in more detail the role of group impression management motives and by studying direct helping (i.e., helping the outgroup believed to hold a negative view of the ingroup). Data from three experiments provided full support for the communicative nature of direct outgroup helping by demonstrating that outgroup helping in response to a negative metastereotype was predicted by participants' concern for the image of their ingroup, but not by their self-image concerns. Moreover, group image concerns predicted outgroup helping but not ingroup helping and predicted outgroup helping only when a negative metastereotype was activated, compared with a positive metastereotype, or a (negative or positive) autostereotype. The results also ruled out an alternative explanation in terms of denying the self-relevance of the metastereotype.

Confocal Microscopy

NASA Astrophysics Data System (ADS)

Liu, Jian; Tan, Jiubin

2016-12-01

The confocal microscope is appropriate for imaging cells or the measurement of industrial artefacts. However, junior researchers and instrument users sometimes misuse imaging concepts and metrological characteristics, such as position resolution in industrial metrology and scale resolution in bio-imaging. And, metrological characteristics or influence factors in 3D measurement such as height assessment error caused by 3D coupling effect are so far not yet identified. In this book, the authors outline their practices by the working experiences on standardization and system design. This book assumes little previous knowledge of optics, but rich experience in engineering of industrial measurements, in particular with profile metrology or areal surface topography will be very helpful to understand the theoretical concerns and value of the technological advances. It should be useful for graduate students or researchers as extended reading material, as well as microscope users alongside their handbook.

Self-generated covalent cross-links in the cell-surface adhesins of Gram-positive bacteria.

PubMed

Baker, Edward N; Squire, Christopher J; Young, Paul G

2015-10-01

The ability of bacteria to adhere to other cells or to surfaces depends on long, thin adhesive structures that are anchored to their cell walls. These structures include extended protein oligomers known as pili and single, multi-domain polypeptides, mostly based on multiple tandem Ig-like domains. Recent structural studies have revealed the widespread presence of covalent cross-links, not previously seen within proteins, which stabilize these domains. The cross-links discovered so far are either isopeptide bonds that link lysine side chains to the side chains of asparagine or aspartic acid residues or ester bonds between threonine and glutamine side chains. These bonds appear to be formed by spontaneous intramolecular reactions as the proteins fold and are strategically placed so as to impart considerable mechanical strength. © 2015 Authors; published by Portland Press Limited.

76 FR 21703 - Approval for Extension of Subzone Status and Manufacturing Authority; Foreign-Trade Subzone 169A...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-18

... Subzone Status and Manufacturing Authority; Foreign-Trade Subzone 169A; Aso LLC; (Adhesive Bandages... indefinitely extend subzone status and manufacturing authority on behalf of Aso LLC, to perform adhesive... LLC (Aso) to perform adhesive bandage manufacturing within FTZ Subzone 169A in Sarasota County...

41 CFR 302-8.203 - What is the authorized time period for extended storage of my HHG?

Code of Federal Regulations, 2010 CFR

2010-07-01

... HHG? Time limitations for extended storage of your HHG will be determined by your agency as follows: (a) For the duration of the OCONUS assignment plus 30 days prior to the time the tour begins and plus...

38 CFR 17.120 - Payment or reimbursement of the expenses of hospital care and other medical services not...

Code of Federal Regulations, 2010 CFR

2010-07-01

... of the expenses of hospital care and other medical services not previously authorized. 17.120 Section... the expenses of hospital care and other medical services not previously authorized. To the extent allowable, payment or reimbursement of the expenses of care, not previously authorized, in a private or...

Learning to Rank Figures within a Biomedical Article

PubMed Central

Liu, Feifan; Yu, Hong

2014-01-01

Hundreds of millions of figures are available in biomedical literature, representing important biomedical experimental evidence. This ever-increasing sheer volume has made it difficult for scientists to effectively and accurately access figures of their interest, the process of which is crucial for validating research facts and for formulating or testing novel research hypotheses. Current figure search applications can't fully meet this challenge as the “bag of figures” assumption doesn't take into account the relationship among figures. In our previous study, hundreds of biomedical researchers have annotated articles in which they serve as corresponding authors. They ranked each figure in their paper based on a figure's importance at their discretion, referred to as “figure ranking”. Using this collection of annotated data, we investigated computational approaches to automatically rank figures. We exploited and extended the state-of-the-art listwise learning-to-rank algorithms and developed a new supervised-learning model BioFigRank. The cross-validation results show that BioFigRank yielded the best performance compared with other state-of-the-art computational models, and the greedy feature selection can further boost the ranking performance significantly. Furthermore, we carry out the evaluation by comparing BioFigRank with three-level competitive domain-specific human experts: (1) First Author, (2) Non-Author-In-Domain-Expert who is not the author nor co-author of an article but who works in the same field of the corresponding author of the article, and (3) Non-Author-Out-Domain-Expert who is not the author nor co-author of an article and who may or may not work in the same field of the corresponding author of an article. Our results show that BioFigRank outperforms Non-Author-Out-Domain-Expert and performs as well as Non-Author-In-Domain-Expert. Although BioFigRank underperforms First Author, since most biomedical researchers are either in- or out-domain-experts for an article, we conclude that BioFigRank represents an artificial intelligence system that offers expert-level intelligence to help biomedical researchers to navigate increasingly proliferated big data efficiently. PMID:24625719

Learning to rank figures within a biomedical article.

PubMed

Liu, Feifan; Yu, Hong

2014-01-01

Hundreds of millions of figures are available in biomedical literature, representing important biomedical experimental evidence. This ever-increasing sheer volume has made it difficult for scientists to effectively and accurately access figures of their interest, the process of which is crucial for validating research facts and for formulating or testing novel research hypotheses. Current figure search applications can't fully meet this challenge as the "bag of figures" assumption doesn't take into account the relationship among figures. In our previous study, hundreds of biomedical researchers have annotated articles in which they serve as corresponding authors. They ranked each figure in their paper based on a figure's importance at their discretion, referred to as "figure ranking". Using this collection of annotated data, we investigated computational approaches to automatically rank figures. We exploited and extended the state-of-the-art listwise learning-to-rank algorithms and developed a new supervised-learning model BioFigRank. The cross-validation results show that BioFigRank yielded the best performance compared with other state-of-the-art computational models, and the greedy feature selection can further boost the ranking performance significantly. Furthermore, we carry out the evaluation by comparing BioFigRank with three-level competitive domain-specific human experts: (1) First Author, (2) Non-Author-In-Domain-Expert who is not the author nor co-author of an article but who works in the same field of the corresponding author of the article, and (3) Non-Author-Out-Domain-Expert who is not the author nor co-author of an article and who may or may not work in the same field of the corresponding author of an article. Our results show that BioFigRank outperforms Non-Author-Out-Domain-Expert and performs as well as Non-Author-In-Domain-Expert. Although BioFigRank underperforms First Author, since most biomedical researchers are either in- or out-domain-experts for an article, we conclude that BioFigRank represents an artificial intelligence system that offers expert-level intelligence to help biomedical researchers to navigate increasingly proliferated big data efficiently.

Extending The Calibration In The Underwater Sound Reference Division (USRD) Reciprocity Coupler To Incorporate Phase

DTIC Science & Technology

2016-09-01

NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS EXTENDING THE CALIBRATION IN THE UNDERWATER SOUND REFERENCE DIVISION (USRD) RECIPROCITY COUPLER...AND DATES COVERED Master’s Thesis 08-01-2014 to 08-21-2016 4. TITLE AND SUBTITLE EXTENDING THE CALIBRATION IN THE UNDERWATER SOUND REFERENCE DIVISION...SPONSORING / MONITORING AGENCY REPORT NUMBER 11. SUPPLEMENTARY NOTES The views expressed in this document are those of the author and do not reflect

Who can I trust? Extended fear during and after the Utøya terrorist attack.

PubMed

Filkuková, Petra; Hafstad, Gertrud Sofie; Jensen, Tine K

2016-07-01

The aim of the study was to investigate specific peritraumatic reactions among adolescent and young adult survivors of the 2011 terrorist attack on Utøya Island, Norway. The authors focused specifically on a phenomenon that has so far not been thoroughly investigated: fear of nondangerous stimuli ("extended fear") during and immediately after the traumatic event. In total, 325 survivors of the shooting on Utøya Island were interviewed 4-5 months after the attack and provided a free narrative of the event. Posttraumatic stress symptoms were assessed using the UCLA PTSD Reaction Index; depression and anxiety were assessed using HSCL-8. For the purpose of the current study, the authors chose participants who were under the age of 26 at the time of the terrorist attack (M = 18.4 years), which constituted the vast majority of the total sample (93%). The authors found that 54% of the sample felt threatened during and immediately after the attack, not only by the perpetrator himself, but by other people as well; in most cases by people who came to help them (medical personnel, policemen, volunteers). The participants who mentioned experiencing extended fear in their trauma narratives had significantly higher scores of posttraumatic stress symptoms, anxiety, and depression 5 months after the attack than participants who did not peritraumatically experience extended fear. Early detection of extended fear can help in identifying individuals who will later develop symptomatology. In addition, knowledge of the phenomenon could help policemen and medical personnel understand survivors' seemingly irrational reactions. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

The Physician Assistant in Geriatric Long-Term Care

ERIC Educational Resources Information Center

Becker, Robert G.

1976-01-01

The Physician Assistant (PA) is a new health-care professional who is trained to function as a "physician extender." The author's experience with 71 PA students and graduate PA's at the Jewish Institute for Geriatric Care is described. (Author)

The Changing Motivations of Students' Use of Lecture Podcasts across a Semester: An Extended Theory of Planned Behaviour Approach

ERIC Educational Resources Information Center

Moss, Nathan D.; Hamilton, Kyra; White, Katherine M.; Hansen, Julie

2015-01-01

We extended the previous work of Moss, O'Connor and White, to include a measure of group norms within the theory of planned behaviour (TPB), to examine the influences on students' decisions to use lecture podcasts as part of their learning. Participants (N?=?90) completed the extended TPB predictors before semester began (Time 1) and mid-semester…

Model-Based Engine Control Architecture with an Extended Kalman Filter

NASA Technical Reports Server (NTRS)

Csank, Jeffrey T.; Connolly, Joseph W.

2016-01-01

This paper discusses the design and implementation of an extended Kalman filter (EKF) for model-based engine control (MBEC). Previously proposed MBEC architectures feature an optimal tuner Kalman Filter (OTKF) to produce estimates of both unmeasured engine parameters and estimates for the health of the engine. The success of this approach relies on the accuracy of the linear model and the ability of the optimal tuner to update its tuner estimates based on only a few sensors. Advances in computer processing are making it possible to replace the piece-wise linear model, developed off-line, with an on-board nonlinear model running in real-time. This will reduce the estimation errors associated with the linearization process, and is typically referred to as an extended Kalman filter. The non-linear extended Kalman filter approach is applied to the Commercial Modular Aero-Propulsion System Simulation 40,000 (C-MAPSS40k) and compared to the previously proposed MBEC architecture. The results show that the EKF reduces the estimation error, especially during transient operation.

Model-Based Engine Control Architecture with an Extended Kalman Filter

NASA Technical Reports Server (NTRS)

Csank, Jeffrey T.; Connolly, Joseph W.

2016-01-01

This paper discusses the design and implementation of an extended Kalman filter (EKF) for model-based engine control (MBEC). Previously proposed MBEC architectures feature an optimal tuner Kalman Filter (OTKF) to produce estimates of both unmeasured engine parameters and estimates for the health of the engine. The success of this approach relies on the accuracy of the linear model and the ability of the optimal tuner to update its tuner estimates based on only a few sensors. Advances in computer processing are making it possible to replace the piece-wise linear model, developed off-line, with an on-board nonlinear model running in real-time. This will reduce the estimation errors associated with the linearization process, and is typically referred to as an extended Kalman filter. The nonlinear extended Kalman filter approach is applied to the Commercial Modular Aero-Propulsion System Simulation 40,000 (C-MAPSS40k) and compared to the previously proposed MBEC architecture. The results show that the EKF reduces the estimation error, especially during transient operation.

Shells, holes, worms, high-velocity gas and the z-distribution of gas in galaxies.

NASA Astrophysics Data System (ADS)

Rand, R. J.

The author gives an overview of the current observational understanding of vertically extended gas components in spiral galaxies and the various phenomena which come under such names as shells, holes, worms, and high-velocity gas. For the most part, the focus is on recent high-resolution interferometric studies. The author concentrates on cold gas, and briefly on warm ionized gas, in the Milky Way and a few nearby spirals. Along the way, it is seen how phenomena such as worms and shells may be related to the formation and maintenance of the vertically extended components.

Providing for consideration of the Senate amendment to the bill (H.R. 4853) to amend the Internal Revenue Code of 1986 to extend the funding and expenditure authority of the Airport and Airway Trust Fund, to amend title 49, United States Code, to extend authorizations for the airport improvement program, and for other purposes, and providing for consideration of motions to suspend the rules.

THOMAS, 111th Congress

Rep. Pingree, Chellie [D-ME-1

2010-12-01

House - 12/02/2010 On agreeing to the resolution Agreed to by the Yeas and Nays: 213 - 203 (Roll no. 597). (All Actions) Tracker: This bill has the status Agreed to in HouseHere are the steps for Status of Legislation:

The discovery of deep-water seagrass meadows in a pristine Indian Ocean wilderness revealed by tracking green turtles.

PubMed

Esteban, N; Unsworth, R K F; Gourlay, J B Q; Hays, G C

2018-03-21

Our understanding of global seagrass ecosystems comes largely from regions characterized by human impacts with limited data from habitats defined as notionally pristine. Seagrass assessments also largely focus on shallow-water coastal habitats with comparatively few studies on offshore deep-water seagrasses. We satellite tracked green turtles (Chelonia mydas), which are known to forage on seagrasses, to a remote, pristine deep-water environment in the Western Indian Ocean, the Great Chagos Bank, which lies in the heart of one of the world's largest marine protected areas (MPAs). Subsequently we used in-situ SCUBA and baited video surveys to survey the day-time sites occupied by turtles and discovered extensive monospecific seagrass meadows of Thalassodendron ciliatum. At three sites that extended over 128 km, mean seagrass cover was 74% (mean range 67-88% across the 3 sites at depths to 29 m. The mean species richness of fish in seagrass meadows was 11 species per site (mean range 8-14 across the 3 sites). High fish abundance (e.g. Siganus sutor: mean MaxN.site -1  = 38.0, SD = 53.7, n = 5) and large predatory shark (Carcharhinus amblyrhynchos) (mean MaxN.site -1  = 1.5, SD = 0.4, n = 5) were recorded at all sites. Such observations of seagrass meadows with large top predators, are limited in the literature. Given that the Great Chagos Bank extends over approximately 12,500 km 2 and many other large deep submerged banks exist across the world's oceans, our results suggest that deep-water seagrass may be far more abundant than previously suspected. Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Biodiversity and the Species Concept-Lineages are not Enough.

PubMed

Freudenstein, John V; Broe, Michael B; Folk, Ryan A; Sinn, Brandon T

2017-07-01

The nature and definition of species continue to be matters of debate. Current views of species often focus on their nature as lineages-maximal reproductive communities through time. Whereas many authors point to the Evolutionary Species Concept as optimal, in its original form it stressed the ecological role of species as well as their history as lineages, but most recent authors have ignored the role aspect of the concept, making it difficult to apply unambiguously in a time-extended way. This trend has been exacerbated by the application of methods and concepts emphasizing the notion of monophyly, originally applied only at higher levels, to the level of individuals, as well as by the current emphasis on molecular data. Hence, some current authors recognize units that are no more than probable exclusive lineages as species. We argue that biodiversity is inherently a phenotypic concept and that role, as manifested in the organismal extended phenotype, is a necessary component of the species concept. Viewing species as historically connected populations with unique role brings together the temporal and phenotypic natures of species, providing a clear way to view species both in a time-limited and time-extended way. Doing so alleviates perceived issues with "paraphyletic species" and returns the focus of species to units that are most relevant for biodiversity. © The Author(s) 2016. Published by Oxford University Press, on behalf of the Society of Systematic Biologists. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

40 CFR 147.1655 - Requirements for wells authorized by permit.

Code of Federal Regulations, 2010 CFR

2010-07-01

... New York § 147.1655 Requirements for wells authorized by permit. (a) The owner or operator of a Class... largest casing string. (b) The owner or operator of a new Class II well authorized by permit shall: (1... volume. (3) For new enhanced recovery wells, install tubing or long string casing extending to the...

3 CFR - Continuation of the National Emergency Relating to Cuba and of the Emergency Authority Relating...

Code of Federal Regulations, 2011 CFR

2011-01-01

... Cuba and of the Emergency Authority Relating to the Regulation of the Anchorage and Movement of Vessels... Emergency Relating to Cuba and of the Emergency Authority Relating to the Regulation of the Anchorage and... north of Cuba. On February 26, 2004, by Proclamation 7757, the national emergency was extended and its...

7 CFR 210.19 - Additional responsibilities.

Code of Federal Regulations, 2013 CFR

2013-01-01

... this part, fiscal action shall be extended back to the beginning of the school year or that point in... severity and longevity of the problem, the State agency may extend fiscal action back to previous school... AGRICULTURE CHILD NUTRITION PROGRAMS NATIONAL SCHOOL LUNCH PROGRAM Requirements for State Agency Participation...

7 CFR 210.19 - Additional responsibilities.

Code of Federal Regulations, 2014 CFR

2014-01-01

... this part, fiscal action shall be extended back to the beginning of the school year or that point in... severity and longevity of the problem, the State agency may extend fiscal action back to previous school... AGRICULTURE CHILD NUTRITION PROGRAMS NATIONAL SCHOOL LUNCH PROGRAM Requirements for State Agency Participation...

Quasi-experimental study designs series-paper 5: a checklist for classifying studies evaluating the effects on health interventions-a taxonomy without labels.

PubMed

Reeves, Barnaby C; Wells, George A; Waddington, Hugh

2017-09-01

The aim of the study was to extend a previously published checklist of study design features to include study designs often used by health systems researchers and economists. Our intention is to help review authors in any field to set eligibility criteria for studies to include in a systematic review that relate directly to the intrinsic strength of the studies in inferring causality. We also seek to clarify key equivalences and differences in terminology used by different research communities. Expert consensus meeting. The checklist comprises seven questions, each with a list of response items, addressing: clustering of an intervention as an aspect of allocation or due to the intrinsic nature of the delivery of the intervention; for whom, and when, outcome data are available; how the intervention effect was estimated; the principle underlying control for confounding; how groups were formed; the features of a study carried out after it was designed; and the variables measured before intervention. The checklist clarifies the basis of credible quasi-experimental studies, reconciling different terminology used in different fields of investigation and facilitating communications across research communities. By applying the checklist, review authors' attention is also directed to the assumptions underpinning the methods for inferring causality. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Extension of Drosophila Lifespan by Rhodiola rosea Depends on Dietary Carbohydrate and Caloric Content in a Simplified Diet.

PubMed

Schriner, Samuel E; Coskun, Volkan; Hogan, Sean P; Nguyen, Cindy T; Lopez, Terry E; Jafari, Mahtab

2016-03-01

The root and rhizome extract of Rhodiola rosea has been extensively used in traditional medicine to improve physical and mental performance and to protect against stress. We, and others, have reported that R. rosea can extend lifespan in flies, worms, and yeast. We also previously found that the extract can act independently of dietary restriction (DR), a treatment that can extend lifespan in a range of model organisms. In flies, DR is implemented through a reduction in dietary yeast content. Here, we report that the ability of R. rosea extract to extend lifespan in flies is dependent on the carbohydrate and caloric content when supplemented with a simplified diet composed of yeast and sucrose. R. rosea extract elevated the sugar content in flies and down-regulated hexokinase expression, suggesting that it perturbs carbohydrate metabolism in flies. In our previous studies, bananas, barley malt, and corn syrup provided dietary carbohydrates, and R. rosea extract could extend lifespan with a range of caloric levels. We conclude that the lifespan-extending effect of R. rosea extract in flies is dependent on dietary carbohydrate and caloric contents coupled with an interaction with complex dietary components present in bananas, barley, or corn.

Southeastern extension of the Lake Basin fault zone in south- central Montana: implications for coal and hydrocarbon exploration ( USA).

USGS Publications Warehouse

Robinson, L.N.; Barnum, B.E.

1986-01-01

The Lake Basin fault zone consists mainly of en echelon NE-striking normal faults that have been interpreted to be surface expressions of left-lateral movement along a basement wrench fault. Information gathered from recent field mapping of coal beds and from shallow, closely-spaced drill holes resulted in detailed coal bed correlations, which revealed another linear zone of en echelon faulting directly on the extended trend of the Lake Basin fault zone. This faulted area, referred to as the Sarpy Creek area, is located 48 km E of Hardin, Montana. It is about 16 km long, 13 km wide, and contains 21 en echelon normal faults that have an average strike of N 63oE. We therefore extend the Lake Basin fault zone 32 km farther SE than previously mapped to include the Sarpy Creek area. The Ash Creek oil field, Wyoming, 97 km due S of the Sarpy Creek area, produces from faulted anticlinal structues that have been interpreted to be genetically related to the primary wrench-fault system known as the Nye-Bowler fault zone. The structural similarities between the Sarpy Creek area and the Ash Creek area indicate that the Sarpy Creek area is a possible site for hydrocarbon accumulation.-from Authors

High precision analytical description of the allowed β spectrum shape

NASA Astrophysics Data System (ADS)

Hayen, Leendert; Severijns, Nathal; Bodek, Kazimierz; Rozpedzik, Dagmara; Mougeot, Xavier

2018-01-01

A fully analytical description of the allowed β spectrum shape is given in view of ongoing and planned measurements. Its study forms an invaluable tool in the search for physics beyond the standard electroweak model and the weak magnetism recoil term. Contributions stemming from finite size corrections, mass effects, and radiative corrections are reviewed. Particular focus is placed on atomic and chemical effects, where the existing description is extended and analytically provided. The effects of QCD-induced recoil terms are discussed, and cross-checks were performed for different theoretical formalisms. Special attention was given to a comparison of the treatment of nuclear structure effects in different formalisms. Corrections were derived for both Fermi and Gamow-Teller transitions, and methods of analytical evaluation thoroughly discussed. In its integrated form, calculated f values were in agreement with the most precise numerical results within the aimed for precision. The need for an accurate evaluation of weak magnetism contributions was stressed, and the possible significance of the oft-neglected induced pseudoscalar interaction was noted. Together with improved atomic corrections, an analytical description was presented of the allowed β spectrum shape accurate to a few parts in 10-4 down to 1 keV for low to medium Z nuclei, thereby extending the work by previous authors by nearly an order of magnitude.

Extending the generality of leaf economic design principles in the cycads, an ancient lineage.

PubMed

Zhang, Yong-Jiang; Cao, Kun-Fang; Sack, Lawren; Li, Nan; Wei, Xue-Mei; Goldstein, Guillermo

2015-04-01

Cycads are the most ancient lineage of living seed plants, but the design of their leaves has received little study. We tested whether cycad leaves are governed by the same fundamental design principles previously established for ferns, conifers and angiosperms, and characterized the uniqueness of this relict lineage in foliar trait relationships. Leaf structure, photosynthesis, hydraulics and nutrient composition were studied in 33 cycad species from nine genera and three families growing in two botanical gardens. Cycads varied greatly in leaf structure and physiology. Similarly to other lineages, light-saturated photosynthetic rate per mass (Am ) was related negatively to leaf mass per area and positively to foliar concentrations of chlorophyll, nitrogen (N), phosphorus and iron, but unlike angiosperms, leaf photosynthetic rate was not associated with leaf hydraulic conductance. Cycads had lower photosynthetic N use efficiency and higher photosynthetic performance relative to hydraulic capacity compared with other lineages. These findings extend the relationships shown for foliar traits in angiosperms to the cycads. This functional convergence supports the modern synthetic understanding of leaf design, with common constraints operating across lineages, even as they highlight exceptional aspects of the biology of this key relict lineage. © 2015 The Authors. New Phytologist © 2015 New Phytologist Trust.

A proposed procedure for expressing the behavior of a full engine cycle by identifying its critical load timings

NASA Astrophysics Data System (ADS)

Marius Andrei, Mihalache; Gheorghe, Nagit; Gavril, Musca; Vasile, Merticaru, Jr.; Marius Ionut, Ripanu

2016-11-01

In the present study the authors propose a new algorithm for identifying the right loads that act upon a functional connecting rod during a full engine cycle. The loads are then divided into three categories depending on the results they produce, as static, semi-dynamic and dynamic ones Because an engine cycle extends up to 720°, the authors aim to identify a method of substitution of values that produce the same effect as a previous value of a considered angle did. In other words, the proposed method aims to pin point the critical values that produce an effect different as the one seen before during a full engine cycle. Only those values will then be considered as valid loads that act upon the connecting rod inside FEA analyses. This technique has been applied to each of the three categories mentioned above and did produced different critical values for each one of them. The whole study relies on a theoretical mechanical project which was developed in order to identify the right values that correspond to each degree of the entire engine cycle of a Daewoo Tico automobile.

The extended Price equation quantifies species selection on mammalian body size across the Palaeocene/Eocene Thermal Maximum.

PubMed

Rankin, Brian D; Fox, Jeremy W; Barrón-Ortiz, Christian R; Chew, Amy E; Holroyd, Patricia A; Ludtke, Joshua A; Yang, Xingkai; Theodor, Jessica M

2015-08-07

Species selection, covariation of species' traits with their net diversification rates, is an important component of macroevolution. Most studies have relied on indirect evidence for its operation and have not quantified its strength relative to other macroevolutionary forces. We use an extension of the Price equation to quantify the mechanisms of body size macroevolution in mammals from the latest Palaeocene and earliest Eocene of the Bighorn and Clarks Fork Basins of Wyoming. Dwarfing of mammalian taxa across the Palaeocene/Eocene Thermal Maximum (PETM), an intense, brief warming event that occurred at approximately 56 Ma, has been suggested to reflect anagenetic change and the immigration of small bodied-mammals, but might also be attributable to species selection. Using previously reconstructed ancestor-descendant relationships, we partitioned change in mean mammalian body size into three distinct mechanisms: species selection operating on resident mammals, anagenetic change within resident mammalian lineages and change due to immigrants. The remarkable decrease in mean body size across the warming event occurred through anagenetic change and immigration. Species selection also was strong across the PETM but, intriguingly, favoured larger-bodied species, implying some unknown mechanism(s) by which warming events affect macroevolution. © 2015 The Author(s).

The experience of family carers attending a joint reminiscence group with people with dementia: A thematic analysis.

PubMed

Melunsky, Nina; Crellin, Nadia; Dudzinski, Emma; Orrell, Martin; Wenborn, Jennifer; Poland, Fiona; Woods, Bob; Charlesworth, Georgina

2015-11-01

Reminiscence therapy has the potential to improve quality of life for people with dementia. In recent years reminiscence groups have extended to include family members, but carers' experience of attending joint sessions is undocumented. This qualitative study explored the experience of 18 family carers attending 'Remembering Yesterday Caring Today' groups. Semi-structured interviews were transcribed and subjected to thematic analysis. Five themes were identified: experiencing carer support; shared experience; expectations (met and unmet), carer perspectives of the person with dementia's experience; and learning and comparing. Family carers' experiences varied, with some experiencing the intervention as entirely positive whereas others had more mixed feelings. Negative aspects included the lack of respite from their relative, the lack of emphasis on their own needs, and experiencing additional stress and guilt through not being able to implement newly acquired skills. These findings may explain the failure of a recent trial of joint reminiscence groups to replicate previous findings of positive benefit. More targeted research within subgroups of carers is required to justify the continued use of joint reminiscence groups in dementia care. © The Author(s) 2013.

Research ethics in victimization studies: widening the lens.

PubMed

Clark, James J; Walker, Robert

2011-12-01

Research ethics, especially the protection of research study participants, has been an enduring concern of investigators and scholars of victims of violence. Previous work has analyzed the overt and hidden risks of harm to study participants through poorly designed and implemented protocols, cross-cultural insensitivity, unjust exclusion of certain victim types, and neglect to ensure safety of research staff. This article extends this work by calling for greater attention to exploiting participants and victims as a class of persons. The need for this wider view derives from concern about the academic research environment with its emphasis on research, publication, and extramural funding. The authors argue that compliance with federal regulations and IRB directives is necessary but insufficient to conduct truly ethical research. Recognition of the unique pressures that researchers face in the context of the economically competitive university is required to delineate and manage exploitation risks. Such pressures have sometimes led to the rush from print to practices and policies with unintended harmful results for victims of violence as a class of persons. The authors suggest a number of strategies for researchers to define and manage the dangers of engaging in this type of unethical conduct.

Micro-CT scan reveals an unexpected high-volume and interconnected pore network in a Cretaceous Sanagasta dinosaur eggshell.

PubMed

Hechenleitner, E Martín; Grellet-Tinner, Gerald; Foley, Matthew; Fiorelli, Lucas E; Thompson, Michael B

2016-03-01

The Cretaceous Sanagasta neosauropod nesting site (La Rioja, Argentina) was the first confirmed instance of extinct dinosaurs using geothermal-generated heat to incubate their eggs. The nesting strategy and hydrothermal activities at this site led to the conclusion that the surprisingly 7 mm thick-shelled eggs were adapted to harsh hydrothermal microenvironments. We used micro-CT scans in this study to obtain the first three-dimensional microcharacterization of these eggshells. Micro-CT-based analyses provide a robust assessment of gas conductance in fossil dinosaur eggshells with complex pore canal systems, allowing calculation, for the first time, of the shell conductance through its thickness. This novel approach suggests that the shell conductance could have risen during incubation to seven times more than previously estimated as the eggshell erodes. In addition, micro-CT observations reveal that the constant widening and branching of pore canals form a complex funnel-like pore canal system. Furthermore, the high density of pore canals and the presence of a lateral canal network in the shell reduce the risks of pore obstruction during the extended incubation of these eggs in a relatively highly humid and muddy nesting environment. © 2016 The Author(s).

Gender Differences in Borderline Personality Disorder: Results From a Multinational, Clinical Trial Sample.

PubMed

Silberschmidt, Amy; Lee, Susanne; Zanarini, Mary; Schulz, S Charles

2015-12-01

This study aims to extend previous research by considering gender differences in borderline personality (BPD) using both dimensional self-reported and clinical measures of symptomatology. Drawing from a cross-cultural, clinical trial sample, the authors compared female and male BPD subjects (N = 770; 211 male) between the ages of 18 and 65 using diagnostic and self-report data. The authors found that women with BPD have greater hostility and relationship disruption than men. Gender differences in eating disorders, particularly bulimia, are more divergent than in the general population. Generally, gender differences in BPD in this sample are consistent with known general population differences. Women show greater overall symptomatology, including depressive, anxious, and somatic symptoms. Men have higher rates of antisocial personality disorder and a trend toward higher rates of narcissistic personality disorder. However, several gender differences consistently found in the general population are not present in this BPD sample. There are no differences in aggression, suicidality, substance abuse, panic disorder, or obsessive-compulsive disorder. Gender differences in major depression and posttraumatic stress disorder are attenuated. These findings support the conclusion that BPD may diminish normal gender differences.

Idiocy and the Law in Colonial New England.

ERIC Educational Resources Information Center

Wickham, Parnel

2001-01-01

A review of laws and records of the courts of colonial New England indicates early laws of Massachusetts extended certain rights to idiots: they authorized the transfer of property, exonerated idiots who committed capital crimes, and extended relief to impoverished idiots. The relationship between colonial laws and present legislation is examined.…

Coherence in the Assessment of Writing Skills

ERIC Educational Resources Information Center

Walker, Robin; Riu, Carmen Perez

2008-01-01

Unhappy with the contradiction of teaching writing skills through a process-genre approach and testing them by means of a timed essay, the authors devised the Extended Writing Project (EWP) as an alternative evaluation mechanism. This requires students to write an extended text in consecutive sections that are drafted and revised with external…

76 FR 18383 - Extension of Sunset Date for Attorney Advisor Program

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-04

... rule. SUMMARY: We are extending for 2 years our rule authorizing attorney advisors to conduct certain prehearing procedures and to issue fully favorable decisions. The current rule will expire on August 10, 2011... would end on August 10, 2009, unless we decided either to terminate the rule earlier or to extend it...

40 CFR 147.1955 - Requirements for wells authorized by permit.

Code of Federal Regulations, 2010 CFR

2010-07-01

... (ii) Cemented back to the surface by recirculating the cement; and (2) Long string casing and tubing... volume. (3) For new enhanced recovery wells, install tubing or long string casing extending to the injection zone. (4) For new salt water disposal wells, install long string casing and tubing extending to...

75 FR 73116 - Delaware River and Bay Oil Spill Advisory Committee; Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-29

... is given under the Federal Advisory Committee Act, 5 U.S.C. App. 2 (Pub. L. 92-463). The Coast Guard Authorization Act of 2010 (Pub. L. 111-281) extended the statutory authorization for the Committee until Dec 31...

Long-term outcomes and recurrence patterns of standard versus extended pancreatectomy for pancreatic head cancer: a multicenter prospective randomized controlled study.

PubMed

Jang, Jin-Young; Kang, Jae Seung; Han, Youngmin; Heo, Jin Seok; Choi, Seong Ho; Choi, Dong Wook; Park, Sang Jae; Han, Sung-Sik; Yoon, Dong Sup; Park, Joon Seong; Yu, Hee Chul; Kang, Koo Jeong; Kim, Sang Geol; Lee, Hongeun; Kwon, Wooil; Yoon, Yoo-Seok; Han, Ho-Seong; Kim, Sun-Whe

2017-07-01

Our previous randomized controlled trial revealed no difference in 2-year overall survival (OS) between extended and standard resection for pancreatic adenocarcinoma. The present study evaluated the 5-year OS and recurrence patterns according to the extent of pancreatectomy. Between 2006 and 2009, 169 consecutive patients were prospectively enrolled and randomized to standard (n = 83) or extended resection (n = 86) groups to compare 5-year OS rate, long-term recurrence patterns and factors associated with long-term survival. The surgical R0 rate was similar between the standard and extended groups (85.5 vs. 90.7%, P = 0.300). Five-year OS (18.4 vs. 14.4%, P = 0.388), 5-year disease-free survival (14.8 vs. 14.0%, P = 0.531), and overall recurrence rates (74.7 vs. 69.9%, P = 0.497) were not significantly different between the two groups, although the incidence of peritoneal seeding was higher in the extended group (25 vs. 8.1%, P = 0.014). Extended pancreatectomy does not have better short-term and long-term survival outcomes, and shows similar R0 rates and overall recurrence rates compared with standard pancreatectomy. Extended pancreatectomy does not have to be performed routinely for all cases of resectable pancreatic adenocarcinoma, especially considering its associated increased morbidity shown in our previous study. © 2017 Japanese Society of Hepato-Biliary-Pancreatic Surgery.

Association of transforming growth-factor alpha gene polymorphisms with nonsyndromic cleft palate only (CPO)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shiang, R.; Lidral, A.C.; Ardinger, H.H.

1993-10-01

Genetic analysis and tissue-specific expression studies support a role for transforming growth-factor alpha (TGFA) in craniofacial development. Previous studies have confirmed an association of alleles for TGFA with nonsyndromic cleft lip with or without cleft palate (CL/P) in humans. The authors carried out a retrospective association study to determine whether specific allelic variants of the TGFA gene are also associated with cleft palate only (CPO). The PCR products from 12 overlapping sets of primers to the TGFA cDNA were examined by using single-strand conformational polymorphism analysis. Four DNA polymorphic sites for TGFA were identified in the 3[prime] untranslated region ofmore » the TGFA gene. These variants, as well as previously identified RFLPs for TGFA, were characterized in case and control populations for CPO by using X[sup 2] analysis. A significant association between alleles of TGFA and CPO was identified which further supports a role for this gene as one of the genetic determinants of craniofacial development. Sequence analysis of the variants disclosed a cluster of three variable sites within 30 bp of each other in the 3[prime] untranslated region previously associated with an antisense transcript. These studies extend the role for TGFA in craniofacial morphogenesis and support an interrelated mechanism underlying nonsyndromic forms of CL/P. 46 refs., 3 figs., 3 tabs.« less

Evaluation of SAMe-TT2R2 Score on Predicting Success With Extended-Interval Warfarin Monitoring.

PubMed

Hwang, Andrew Y; Carris, Nicholas W; Dietrich, Eric A; Gums, John G; Smith, Steven M

2018-06-01

In patients with stable international normalized ratios, 12-week extended-interval warfarin monitoring can be considered; however, predictors of success with this strategy are unknown. The previously validated SAMe-TT 2 R 2 score (considering sex, age, medical history, treatment, tobacco, and race) predicts anticoagulation control during standard follow-up (every 4 weeks), with lower scores associated with greater time in therapeutic range. To evaluate the ability of the SAMe-TT 2 R 2 score in predicting success with extended-interval warfarin follow-up in patients with previously stable warfarin doses. In this post hoc analysis of a single-arm feasibility study, baseline SAMe-TT 2 R 2 scores were calculated for patients with ≥1 extended-interval follow-up visit. The primary analysis assessed achieved weeks of extended-interval follow-up according to baseline SAMe-TT 2 R 2 scores. A total of 47 patients receiving chronic anticoagulation completed a median of 36 weeks of extended-interval follow-up. The median baseline SAMe-TT 2 R 2 score was 1 (range 0-5). Lower SAMe-TT 2 R 2 scores appeared to be associated with greater duration of extended-interval follow-up achieved, though the differences between scores were not statistically significant. No individual variable of the SAMe-TT 2 R 2 score was associated with achieved weeks of extended-interval follow-up. Analysis of additional patient factors found that longer duration (≥24 weeks) of prior stable treatment was significantly associated with greater weeks of extended-interval follow-up completed ( P = 0.04). Conclusion and Relevance: This pilot study provides limited evidence that the SAMe-TT 2 R 2 score predicts success with extended-interval warfarin follow-up but requires confirmation in a larger study. Further research is also necessary to establish additional predictors of successful extended-interval warfarin follow-up.

The Four-Factor Model of Depressive Symptoms in Dementia Caregivers: A Structural Equation Model of Ethnic Differences

PubMed Central

Roth, David L.; Ackerman, Michelle L.; Okonkwo, Ozioma C.; Burgio, Louis D.

2008-01-01

Previous studies have suggested that 4 latent constructs (depressed affect, well-being, interpersonal problems, somatic symptoms) underlie the item responses on the Center for Epidemiological Studies Depression (CES-D) Scale. This instrument has been widely used in dementia caregiving research, but the fit of this multifactor model and the explanatory contributions of multifactor models have not been sufficiently examined for caregiving samples. The authors subjected CES-D data (N = 1,183) from the initial Resources for Enhancing Alzheimer’s Caregiver Health Study to confirmatory factor analysis methods and found that the 4-factor model provided excellent fit to the observed data. Invariance analyses suggested only minimal item-loading differences across race subgroups and supported the validity of race comparisons on the latent factors. Significant race differences were found on 3 of the 4 latent factors both before and after controlling for demographic covariates. African Americans reported less depressed affect and better well-being than White caregivers, who reported better well-being and fewer interpersonal problems than Hispanic caregivers. These findings clarify and extend previous studies of race differences in depression among diverse samples of dementia caregivers. PMID:18808246

The role of statistical fluctuations on the stability of shockwaves through gases with activated inelastic collisions

NASA Astrophysics Data System (ADS)

Sirmas, Nick; Radulescu, Matei

2016-11-01

The present study addresses the stability of piston driven shock waves through a system of hard particles subject to activated inelastic collisions. Molecular Dynamics (MD) simulations have previously revealed an unstable structure for such a system in the form of high density non-uniformities and convective rolls within the shock structure. The work has now been extended to the continuum level by considering the Euler and Navier-Stokes equations for granular gases with a modified cooling rate to include an impact threshold necessary for inelastic collisions. We find that the pattern formations produced in MD can be reproduced at the continuum level by continually perturbing the incoming density field. By varying the perturbation amplitude and wavelength, we find that fluctuations consistent with the statistical fluctuations seen in MD yield similar instabilities to those previously observed. While the inviscid model predicts a highly chaotic structure from these perturbations, the inclusion of viscosity and heat conductivity yields equivalent wavelengths of pattern formations to those seen in MD, which is equal to the relaxation length scale of the dissipative shock structure. The authors acknowledged funding through the Alexander Graham Bell Canada Graduate Scholarship (NSERC) and Ontario Graduate Scholarship.

Age- and bite-structured models for vector-borne diseases.

PubMed

Rock, K S; Wood, D A; Keeling, M J

2015-09-01

The biology and behaviour of biting insects is a vitally important aspect in the spread of vector-borne diseases. This paper aims to determine, through the use of mathematical models, what effect incorporating vector senescence and realistic feeding patterns has on disease. A novel model is developed to enable the effects of age- and bite-structure to be examined in detail. This original PDE framework extends previous age-structured models into a further dimension to give a new insight into the role of vector biting and its interaction with vector mortality and spread of disease. Through the PDE model, the roles of the vector death and bite rates are examined in a way which is impossible under the traditional ODE formulation. It is demonstrated that incorporating more realistic functions for vector biting and mortality in a model may give rise to different dynamics than those seen under a more simple ODE formulation. The numerical results indicate that the efficacy of control methods that increase vector mortality may not be as great as predicted under a standard host-vector model, whereas other controls including treatment of humans may be more effective than previously thought. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

A separate universe view of the asymmetric sky

NASA Astrophysics Data System (ADS)

Kobayashi, Takeshi; Cortês, Marina; Liddle, Andrew R.

2015-05-01

We provide a unified description of the hemispherical asymmetry in the cosmic microwave background generated by the mechanism proposed by Erickcek, Kamionkowski, and Carroll, using a δ Script N formalism that consistently accounts for the asymmetry-generating mode throughout. We derive a general form for the power spectrum which explicitly exhibits the broken translational invariance. This can be directly compared to cosmic microwave background observables, including the observed quadrupole and fNL values, automatically incorporating the Grishchuk-Zel'dovich effect. Our calculation unifies and extends previous calculations in the literature, in particular giving the full dependence of observables on the phase of our location in the super-horizon mode that generates the asymmetry. We demonstrate how the apparently different results obtained by previous authors arise as different limiting cases. We confirm the existence of non-linear contributions to the microwave background quadrupole from the super-horizon mode identified by Erickcek et al. and further explored by Kanno et al., and show that those contributions are always significant in parameter regimes capable of explaining the observed asymmetry. We indicate example parameter values capable of explaining the observed power asymmetry without violating other observational bounds.

Missions and Mobility Configurations for RED HORSE

DTIC Science & Technology

1988-04-01

use in other research reports or educational pursuits contingent upon the following stipulations: - Reproduction rights do not extend to any copyrighted...MOBILITY CONFIGURATIONS FOR RED HORSE AUTHOR(S) MAJOR JAMES T. RYBURN, USAF FACULTY ADVISOR LT COL ROBERT L. PETERS, ACSC/3823 STUS SPONSOR COL ROBERT J...Classification) MISSIONS AND MOBILITY CONFIGURATIONS FOR RED HORSE 12. PERSONAL AUTHOR(S) Ryburn, James T., Maj or, USAF 13a. TYPE OF REPORT J13b. TIME

78 FR 13207 - Continuation of the National Emergency With Respect to Cuba and of the Emergency Authority...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-26

...--Continuation of the National Emergency With Respect to Cuba and of the Emergency Authority Relating to the... Respect to Cuba and of the Emergency Authority Relating to the Regulation of the Anchorage and Movement of... north of Cuba. On February 26, 2004, by Proclamation 7757, the national emergency was extended and its...

76 FR 11071 - Continuation of the National Emergency With Respect to Cuba and of the Emergency Authority...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-28

...--Continuation of the National Emergency With Respect to Cuba and of the Emergency Authority Relating to the... Respect to Cuba and of the Emergency Authority Relating to the Regulation of the Anchorage and Movement of... north of Cuba. On February 26, 2004, by Proclamation 7757, the national emergency was extended and its...

Volcanic Tremors in the Third Circuit: First Amendment Freedom of Speech Protections through Common Law Authority.

ERIC Educational Resources Information Center

Sanders, Wayne C.

The authority of the First Amendment may transcend the strictures of its original wording, which limits it to proscriptions of federal government suppression of speech. Attempts by some courts to extend First Amendment authority to the workplace is clearly related to the growing criticism of unrestrained managerial dismissal power. The first major…

Payload specialist Reinhard Furrer show evidence of previous blood sampling

NASA Technical Reports Server (NTRS)

1985-01-01

Payload specialist Reinhard Furrer shows evidence of previous blood sampling while Wubbo J. Ockels, Dutch payload specialist (only partially visible), extends his right arm after a sample has been taken. Both men show bruises on their arms.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Falcón, R. M.; Núñez, J.

Based on the traditional concept of isotopism, extended isotopisms were introduced by the authors in 2006 in order to provide a fundamental basis to the isotheory of Santilli. Since that first attempt, distinct studies on extended isotopisms have focused on the construction of partial Latin squares having a Santilli autotopism in their autotopism group. In order to deal with new structures, we introduce in this paper the concept of extended pseudoisotopism. This is based on the use of onto linear transformations that are not necessarily injective. Some examples are exposed throughout the paper.

Comparison of 2 chromogenic media for the detection of extended-spectrum β-lactamase producing Enterobacteriaceae stool carriage in nursing home residents.

PubMed

Blane, Beth; Brodrick, Hayley J; Gouliouris, Theodore; Ambridge, Kirsty E; Kidney, Angela D; Ludden, Catherine M; Limmathurotsakul, Direk; Török, M Estée; Peacock, Sharon J

2016-03-01

ChromID ESBL agar and Brilliance ESBL agar were compared for the isolation of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae from 298 stools. These had comparable sensitivity and selectivity for the 116 positive samples. Pre-enrichment with cefpodoxime and extending incubation to 48 hours after direct plating both significantly increased sensitivity but reduced selectivity of both agars. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

A method of computer modelling the lithium-ion batteries aging process based on the experimental characteristics

NASA Astrophysics Data System (ADS)

Czerepicki, A.; Koniak, M.

2017-06-01

The paper presents a method of modelling the processes of aging lithium-ion batteries, its implementation as a computer application and results for battery state estimation. Authors use previously developed behavioural battery model, which was built using battery operating characteristics obtained from the experiment. This model was implemented in the form of a computer program using a database to store battery characteristics. Batteries aging process is a new extended functionality of the model. Algorithm of computer simulation uses a real measurements of battery capacity as a function of the battery charge and discharge cycles number. Simulation allows to take into account the incomplete cycles of charge or discharge battery, which are characteristic for transport powered by electricity. The developed model was used to simulate the battery state estimation for different load profiles, obtained by measuring the movement of the selected means of transport.

Building one molecule from a reservoir of two atoms.

PubMed

Liu, L R; Hood, J D; Yu, Y; Zhang, J T; Hutzler, N R; Rosenband, T; Ni, K-K

2018-05-25

Chemical reactions typically proceed via stochastic encounters between reactants. Going beyond this paradigm, we combined exactly two atoms in a single, controlled reaction. The experimental apparatus traps two individual laser-cooled atoms [one sodium (Na) and one cesium (Cs)] in separate optical tweezers and then merges them into one optical dipole trap. Subsequently, photoassociation forms an excited-state NaCs molecule. The discovery of previously unseen resonances near the molecular dissociation threshold and measurement of collision rates are enabled by the tightly trapped ultracold sample of atoms. As laser-cooling and trapping capabilities are extended to more elements, the technique will enable the study of more diverse, and eventually more complex, molecules in an isolated environment, as well as synthesis of designer molecules for qubits. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Biotransformation of glyceryl trinitrate (GTN) in isolated bovine pulmonary artery (BPA) and bovine pulmonary vein (BPV)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1986-03-01

A proposed mechanism of GTN-induced vasodilation requires biotransformation of GTN to glyceryl dinitrate (GDN). They have previously shown that GTN is metabolized to GDN during relaxation of isolated rabbit aorta. The authors have extended this study to include BPA and BPV and to determine if their sensitivity to GTN correlates with their ability to metabolize GTN. Strips of BPA and BPV were contracted submaximally with KCl and then incubated with 0.5 ..mu..M /sup 14/C-GTN for 2 min. GTN-induced relaxation of these vessels was monitored and tissue GTN and metabolite concentrations were measured. Data are presented which support the above hypothesismore » that GTN biotransformation and relaxation occur together in vascular smooth muscle; however, there appear to be factors other than extent of GTN biotransformation that account for the difference in sensitivity to GTN of the artery and vein.« less

Performance of Chevron-notch short bar specimen in determining the fracture toughness of silicon nitride and aluminum oxide

NASA Technical Reports Server (NTRS)

Munz, D.; Bubsey, R. T.; Shannon, J. L., Jr.

1980-01-01

Ease of preparation and testing are advantages unique to the chevron-notch specimen used for the determination of the plane strain fracture toughness of extremely brittle materials. During testing, a crack develops at the notch tip and extends stably as the load is increased. For a given specimen and notch configuration, maximum load always occurs at the same relative crack length independent of the material. Fracture toughness is determined from the maximum load with no need for crack length measurement. Chevron notch acuity is relatively unimportant since a crack is produced during specimen loading. In this paper, the authors use their previously determined stress intensity factor relationship for the chevron-notch short bar specimen to examine the performance of that specimen in determining the plane strain fracture toughness of silicon nitride and aluminum oxide.

Dynamic steady-state analysis of crack propagation in rubber-like solids using an extended finite element method

NASA Astrophysics Data System (ADS)

Kroon, Martin

2012-01-01

In the present study, a computational framework for studying high-speed crack growth in rubber-like solids under conditions of plane stress and steady-state is proposed. Effects of inertia, viscoelasticity and finite strains are included. The main purpose of the study is to examine the contribution of viscoelastic dissipation to the total work of fracture required to propagate a crack in a rubber-like solid. The computational framework builds upon a previous work by the present author (Kroon in Int J Fract 169:49-60, 2011). The model was fully able to predict experimental results in terms of the local surface energy at the crack tip and the total energy release rate at different crack speeds. The predicted distributions of stress and dissipation around the propagating crack tip are presented. The predicted crack tip profiles also agree qualitatively with experimental findings.

Is perceived emotional support beneficial? Well-being and health in independent and interdependent cultures.

PubMed

Uchida, Yukiko; Kitayama, Shinobu; Mesquita, Batja; Reyes, Jose Alberto S; Morling, Beth

2008-06-01

Previous studies show there is little or no association between perceived emotional support and well-being in European American culture. The authors hypothesized that this paradoxical absence of any benefit of perceived support is unique to cultural contexts that privilege independence rather than interdependence of the self. Study 1 tested college students and found, as predicted, that among Euro-Americans a positive effect of perceived emotional support on subjective well-being (positive affect) was weak and, moreover, it disappeared entirely once self-esteem was statistically controlled. In contrast, among Asians in Asia (Japanese and Filipinos) perceived emotional support positively predicted subjective well-being even after self-esteem was controlled. Study 2 extended Study 1 by testing both Japanese and American adults in midlife with respect to multiple indicators of well-being and physical health. Overall, the evidence underscores the central significance of culture as a moderator of the effectiveness of perceived emotional support.

Identification of a primordial asteroid family constrains the original planetesimal population.

PubMed

Delbo', Marco; Walsh, Kevin; Bolin, Bryce; Avdellidou, Chrysa; Morbidelli, Alessandro

2017-09-08

A quarter of known asteroids is associated with more than 100 distinct asteroid families, meaning that these asteroids originate as impact fragments from the family parent bodies. The determination of which asteroids of the remaining population are members of undiscovered families, or accreted as planetesimals from the protoplanetary disk, would constrain a critical phase of planetary formation by unveiling the unknown planetesimal size distribution. We discovered a 4-billion-year-old asteroid family extending across the entire inner part of the main belt whose members include most of the dark asteroids previously unlinked to families. This allows us to identify some original planetesimals, which are all larger than 35 kilometers, supporting the view of asteroids being born big. Their number matches the known distinct meteorite parent bodies. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Study geomorphology, past and present, linear trench, tectonics relationship between Pyrenees and Alps

NASA Technical Reports Server (NTRS)

Guillemot, J. (Principal Investigator)

1974-01-01

The author has identified the following significant results. ERTS-1 images obviously show up some large linear features trending N 80 E or N 30 E common to both Alps and Pyrenees. One of them, the Ligurian Fault, had been previously forecast by Laubscher in an interpretation of the Alps by the plate tectonic theory, but it extends westward farthest from the Alps, cutting the Pyrenees axis. These lineaments have been interpreted as reflections of deep seated wrench faults in the surficial part of the sedimentary series. A large set of such lineaments is perceptible in western Europe, such as the Guadalquivir Fault in southern Spain, Ligurian Fault, Insubrian Fault, Northern-Jura Fault, Metz Fault. Perhaps these may be interpreted as transform faults of the mid-Atlantic ridge or of a paleo-rift seated in the Rhine-Rhone graben.

Effect of Sodium Hydroxide Pretreatment of UOP IONSIV IE-911 Crystalline Silicotitanate Sorbent

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilmarth, W.R.

2000-08-29

Use of crystalline silicotitanate (CST) to remove cesium represents one of the alternatives identified for High Level Waste pretreatment at the Savannah River Site (SRS). Previous deployment of CST in the Department of Energy complex subjected the material to mildly caustic environments. Processing of SRS waste will expose CST to very alkaline solutions for extended period of time (typically 12 months in the proposed design). Results of elevated temperature stability tests showed that silicon and one of the proprietary materials leached from the CST. UOP personnel indicated to SRS personnel that these materials exist in the sorbent in excess ofmore » required stoichiometry. The authors examined the pretreatment of CST with sodium hydroxide to remove these components prior to placing the CST in radioactive service. Additionally, researchers analyzed solids discovered in the feed line during a test by non-destructive techniques.« less

Experimental measurement of stationary SS 304, SS 316L and 8630 GTA weld pool surface temperatures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kraus, H.G.

1989-07-01

The optical spectral radiometric/laser reflectance experimental method, previously developed by the author, was extended to obtain high-resolution surface temperature maps of stationary GTA molten weld pools using thick-plate SS 304, SS316L, and 8630 steel. Increasing the welding current from 50 to 200 A resulted in peak pool surface temperatures from 1050{sup 0} to 2400{sup 0}C for the SS 304. At a constant welding current of 150 A, the SS 304 and various heats of SS 316L and 8630 resulted in peak weld pool temperatures from 2300{sup 0} to 2700{sup 0}C. Temperature contour plots of all the welds made are given.more » Surface temperature maps are classified into types that are believed to be indicative of the convective circulation patterns present in the weld pools.« less

Helping the One You Hurt: Toddlers' Rudimentary Guilt, Shame, and Prosocial Behavior After Harming Another.

PubMed

Drummond, Jesse D K; Hammond, Stuart I; Satlof-Bedrick, Emma; Waugh, Whitney E; Brownell, Celia A

2017-07-01

This study explored the role of guilt and shame in early prosocial behavior by extending previous findings that guilt- and shame-like responses can be distinguished in toddlers and, for the first time, examining their associations with helping. Toddlers (n = 32; M age  = 28.9 months) were led to believe they broke an adult's toy, after which they exhibited either a guilt-like response that included frequently confessing their behavior and trying to repair the toy; or a shame-like response that included frequently avoiding the adult and seldom confessing or attempting to repair the toy. In subsequent prosocial tasks, children showing a guilt-like response helped an adult in emotional distress significantly faster and more frequently than did children showing a shame-like response. © 2016 The Authors. Child Development © 2016 Society for Research in Child Development, Inc.

Cost-effective non-surgical treatment of chronic pressure ulcers in the community.

PubMed

Dale, Megan; Cox-Martin, Bill; Shaw, Paula; Carolan-Rees, Grace

2014-03-01

The Salisbury Pressure Ulcer Outreach Service successfully treats patients with chronic pressure ulcers that have not healed during routine community treatment. These patients have grade 4 pressure ulcers, involving extensive destruction, or damage to muscle and bone. A combination of scientific, seating and tissue viability expertise with a holistic approach results in non-surgical healing for 70% of patients. For those who still require surgery, outcomes are more successful with this approach, resulting in low recurrence rates. Prior to creation of the outreach service, patients were referred directly for surgical closure, resulting in high recurrence levels and long waiting lists. The authors compared costs of the Pressure Ulcer Outreach Service with the previous system of surgical closure. The model base case found that the Pressure Ulcer Outreach Service saved £8588 per patient, and that cost savings could be even greater if the outreach service was extended into preventative work.

Extending and Applying the EPIC Architecture for Human Cognition and Performance: Auditory and Spatial Components

DTIC Science & Technology

2013-03-20

Wakefield of the University of Michigan as Co-PI. This extended activity produced a large number of products and accomplishments; however, this report...speech communication will be expanded to provide a robust modeling and prediction capability for tasks involving speech production and speech and non...preparations made to move to the newer Cocoa API instead of the previous Carbon API. In the following sections, an extended treatment will be

Changes in the Influence of Alcohol-Paired Stimuli on Alcohol Seeking across Extended Training

PubMed Central

Corbit, Laura H.; Janak, Patricia H.

2016-01-01

Previous work has demonstrated that goal-directed control of alcohol-seeking and other drug-related behaviors is reduced following extended self-administration and drug exposure. Here, we examined how the magnitude of stimulus influences on responding changes across similar training and drug exposure. Rats self-administered alcohol or sucrose for 2 or 8 weeks. Previous work has shown that 8 weeks, but not 2 weeks of self-administration produces habitual alcohol seeking. Next, all animals received equivalent Pavlovian conditioning sessions where a discrete stimulus predicted the delivery of alcohol or sucrose. Finally, the impact of the stimuli on ongoing instrumental responding was examined in a Pavlovian–instrumental transfer (PIT) test. While a significant PIT effect was observed following 2 weeks of either alcohol or sucrose self-administration, the magnitude of this effect was greater following 8 weeks of training. The specificity of the PIT effect appeared unchanged by extended training. While it is well established that evaluation of the outcome of responding contributes less to behavioral control following extended training and/or drug exposure, our data indicate that reward–predictive stimuli have a stronger contribution to responding after extended training. Together, these findings provide insight into the factors that control behavior after extended drug use, which will be important for developing effective methods for controlling and ideally reducing these behaviors. PMID:27777560

Hearings on the President's Youth Education and Employment Initiative. Hearings Before the Subcommittee on Elementary, Secondary, and Vocational Education of the Committee on Education and Labor, House of Representatives, 96th Congress, Second Session, on H.R. 6711. Hearings Held in Washington, D.C. on February 25, 26, 27, 28; March 3, 4, 5, 6, and 13, 1980.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on Education and Labor.

These congressional hearings contain testimony given in Washington, D.C. at nine hearings pertinent to the H.R. 6711 (Youth Act of 1980) and H.R. 6897 (Amendments to the Elementary Secondary Education Act of 1965). (These are bills to extend the authorization and improve youth training and employment programs, to extend the authorization of the…

Maltreatment and Delinquency in China: Examining and Extending the Intervening Process of General Strain Theory.

PubMed

Gao, Yunjiao; Wong, Dennis S W; Yu, Yanping

2016-01-01

Using a sample of 1,163 adolescents from four middle schools in China, this study explores the intervening process of how adolescent maltreatment is related to delinquency within the framework of general strain theory (GST) by comparing two models. The first model is Agnew's integrated model of GST, which examines the mediating effects of social control, delinquent peer affiliation, state anger, and depression on the relationship between maltreatment and delinquency. Based on this model, with the intent to further explore the mediating effects of state anger and depression and to investigate whether their effects on delinquency can be demonstrated more through delinquent peer affiliation and social control, an extended model (Model 2) is proposed by the authors. The second model relates state anger to delinquent peer affiliation and state depression to social control. By comparing the fit indices and the significance of the hypothesized paths of the two models, the study found that the extended model can better reflect the mechanism of how maltreatment contributes to delinquency, whereas the original integrated GST model only receives partial support because of its failure to find the mediating effects of state negative emotions. © The Author(s) 2014.

Electrostatics of proteins in dielectric solvent continua. II. First applications in molecular dynamics simulations

NASA Astrophysics Data System (ADS)

Stork, Martina; Tavan, Paul

2007-04-01

In the preceding paper by Stork and Tavan, [J. Chem. Phys. 126, 165105 (2007)], the authors have reformulated an electrostatic theory which treats proteins surrounded by dielectric solvent continua and approximately solves the associated Poisson equation [B. Egwolf and P. Tavan, J. Chem. Phys. 118, 2039 (2003)]. The resulting solution comprises analytical expressions for the electrostatic reaction field (RF) and potential, which are generated within the protein by the polarization of the surrounding continuum. Here the field and potential are represented in terms of Gaussian RF dipole densities localized at the protein atoms. Quite like in a polarizable force field, also the RF dipole at a given protein atom is induced by the partial charges and RF dipoles at the other atoms. Based on the reformulated theory, the authors have suggested expressions for the RF forces, which obey Newton's third law. Previous continuum approaches, which were also built on solutions of the Poisson equation, used to violate the reactio principle required by this law, and thus were inapplicable to molecular dynamics (MD) simulations. In this paper, the authors suggest a set of techniques by which one can surmount the few remaining hurdles still hampering the application of the theory to MD simulations of soluble proteins and peptides. These techniques comprise the treatment of the RF dipoles within an extended Lagrangian approach and the optimization of the atomic RF polarizabilities. Using the well-studied conformational dynamics of alanine dipeptide as the simplest example, the authors demonstrate the remarkable accuracy and efficiency of the resulting RF-MD approach.

Interpolation of the Extended Boolean Retrieval Model.

ERIC Educational Resources Information Center

Zanger, Daniel Z.

2002-01-01

Presents an interpolation theorem for an extended Boolean information retrieval model. Results show that whenever two or more documents are similarly ranked at any two points for a query containing exactly two terms, then they are similarly ranked at all points in between; and that results can fail for queries with more than two terms. (Author/LRW)

"Because That's Who I Am": Extending Theories of Culturally Responsive Pedagogy to Consider Religious Identity, Belief, and Practice

ERIC Educational Resources Information Center

Dallavis, Christian

2011-01-01

In this conceptual article the author explores the intersection of culturally responsive pedagogy and religious school contexts. He extends theories of culturally responsive pedagogy to consider how religion, a dimension of student culture that has largely been overlooked in the literature surrounding culturally responsive pedagogy, can inflect…

Extending the Principles of Intensive Writing to Large Macroeconomics Classes

ERIC Educational Resources Information Center

Docherty, Peter; Tse, Harry; Forman, Ross; McKenzie, Jo

2010-01-01

The authors report on the design and implementation of a pilot program to extend the principles of intensive writing outlined by W. Lee Hansen (1998), Murray S. Simpson and Shireen E. Carroll (1999) and David Carless (2006) to large macroeconomics classes. The key aspect of this program was its collaborative nature, with staff from two specialist…

How Far Is Leadership Distributed in Extended Services Provision?

ERIC Educational Resources Information Center

Fuller, Kay; Parsons, Sarah; MacNab, Natasha; Thomas, Hywel

2013-01-01

This study focuses on the leadership engagement of children, young people (CYP) and their families in six school-based extended services (ES) clusters in a single, large, urban local authority in England. Empirical research was carried out in two strands of activity that focused on outcomes and experiences for CYP and leaders and leadership.…

Demographic Trends as a Stimulus to Extended Post-Secondary Education in the Federal Republic of Germany.

ERIC Educational Resources Information Center

Brandes, Uwe; Raters, Ernst

1981-01-01

The effect of a sharp fall in the birth rate on German universities and the need to identify new target student groups are considered. The implementation of extended education and three matters of significance in promoting it (prospective audience, organization, and use of appropriate distance-study materials) are discussed. (Author/MLW)

76 FR 79244 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-21

... Change To Extend the Penny Pilot Program December 15, 2011. Pursuant to Section 19(b)(1) of the... a proposal for the BATS Options Market (``BATS Options'') to extend through June 30, 2012, the Penny Pilot Program (``Penny Pilot'') in options classes in certain issues (``Pilot Program'') previously...

20 CFR 10.740 - In what situations will OWCP automatically presume that a law enforcement officer is covered by...

Code of Federal Regulations, 2013 CFR

2013-04-01

... authority to assist a Federal law enforcement authority in the protection of the President of the United... will be extended. (b) Coverage for officers of the U.S. Park Police and those officers of the Uniformed...

20 CFR 10.740 - In what situations will OWCP automatically presume that a law enforcement officer is covered by...

Code of Federal Regulations, 2011 CFR

2011-04-01

... authority to assist a Federal law enforcement authority in the protection of the President of the United... will be extended. (b) Coverage for officers of the U.S. Park Police and those officers of the Uniformed...

20 CFR 10.740 - In what situations will OWCP automatically presume that a law enforcement officer is covered by...

Code of Federal Regulations, 2014 CFR

2014-04-01

... authority to assist a Federal law enforcement authority in the protection of the President of the United... will be extended. (b) Coverage for officers of the U.S. Park Police and those officers of the Uniformed...

20 CFR 10.740 - In what situations will OWCP automatically presume that a law enforcement officer is covered by...

Code of Federal Regulations, 2010 CFR

2010-04-01

... authority to assist a Federal law enforcement authority in the protection of the President of the United... will be extended. (b) Coverage for officers of the U.S. Park Police and those officers of the Uniformed...

20 CFR 10.740 - In what situations will OWCP automatically presume that a law enforcement officer is covered by...

Code of Federal Regulations, 2012 CFR

2012-04-01

... authority to assist a Federal law enforcement authority in the protection of the President of the United... will be extended. (b) Coverage for officers of the U.S. Park Police and those officers of the Uniformed...

78 FR 47546 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-06

... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft... Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Model... Aviation Authority of Israel (CAAI), which is the aviation authority for Israel, has issued Israeli...

Prostate segmentation by sparse representation based classification

PubMed Central

Gao, Yaozong; Liao, Shu; Shen, Dinggang

2012-01-01

Purpose: The segmentation of prostate in CT images is of essential importance to external beam radiotherapy, which is one of the major treatments for prostate cancer nowadays. During the radiotherapy, the prostate is radiated by high-energy x rays from different directions. In order to maximize the dose to the cancer and minimize the dose to the surrounding healthy tissues (e.g., bladder and rectum), the prostate in the new treatment image needs to be accurately localized. Therefore, the effectiveness and efficiency of external beam radiotherapy highly depend on the accurate localization of the prostate. However, due to the low contrast of the prostate with its surrounding tissues (e.g., bladder), the unpredicted prostate motion, and the large appearance variations across different treatment days, it is challenging to segment the prostate in CT images. In this paper, the authors present a novel classification based segmentation method to address these problems. Methods: To segment the prostate, the proposed method first uses sparse representation based classification (SRC) to enhance the prostate in CT images by pixel-wise classification, in order to overcome the limitation of poor contrast of the prostate images. Then, based on the classification results, previous segmented prostates of the same patient are used as patient-specific atlases to align onto the current treatment image and the majority voting strategy is finally adopted to segment the prostate. In order to address the limitations of the traditional SRC in pixel-wise classification, especially for the purpose of segmentation, the authors extend SRC from the following four aspects: (1) A discriminant subdictionary learning method is proposed to learn a discriminant and compact representation of training samples for each class so that the discriminant power of SRC can be increased and also SRC can be applied to the large-scale pixel-wise classification. (2) The L1 regularized sparse coding is replaced by the elastic net in order to obtain a smooth and clear prostate boundary in the classification result. (3) Residue-based linear regression is incorporated to improve the classification performance and to extend SRC from hard classification to soft classification. (4) Iterative SRC is proposed by using context information to iteratively refine the classification results. Results: The proposed method has been comprehensively evaluated on a dataset consisting of 330 CT images from 24 patients. The effectiveness of the extended SRC has been validated by comparing it with the traditional SRC based on the proposed four extensions. The experimental results show that our extended SRC can obtain not only more accurate classification results but also smoother and clearer prostate boundary than the traditional SRC. Besides, the comparison with other five state-of-the-art prostate segmentation methods indicates that our method can achieve better performance than other methods under comparison. Conclusions: The authors have proposed a novel prostate segmentation method based on the sparse representation based classification, which can achieve considerably accurate segmentation results in CT prostate segmentation. PMID:23039673

Prostate segmentation by sparse representation based classification.

PubMed

Gao, Yaozong; Liao, Shu; Shen, Dinggang

2012-10-01

The segmentation of prostate in CT images is of essential importance to external beam radiotherapy, which is one of the major treatments for prostate cancer nowadays. During the radiotherapy, the prostate is radiated by high-energy x rays from different directions. In order to maximize the dose to the cancer and minimize the dose to the surrounding healthy tissues (e.g., bladder and rectum), the prostate in the new treatment image needs to be accurately localized. Therefore, the effectiveness and efficiency of external beam radiotherapy highly depend on the accurate localization of the prostate. However, due to the low contrast of the prostate with its surrounding tissues (e.g., bladder), the unpredicted prostate motion, and the large appearance variations across different treatment days, it is challenging to segment the prostate in CT images. In this paper, the authors present a novel classification based segmentation method to address these problems. To segment the prostate, the proposed method first uses sparse representation based classification (SRC) to enhance the prostate in CT images by pixel-wise classification, in order to overcome the limitation of poor contrast of the prostate images. Then, based on the classification results, previous segmented prostates of the same patient are used as patient-specific atlases to align onto the current treatment image and the majority voting strategy is finally adopted to segment the prostate. In order to address the limitations of the traditional SRC in pixel-wise classification, especially for the purpose of segmentation, the authors extend SRC from the following four aspects: (1) A discriminant subdictionary learning method is proposed to learn a discriminant and compact representation of training samples for each class so that the discriminant power of SRC can be increased and also SRC can be applied to the large-scale pixel-wise classification. (2) The L1 regularized sparse coding is replaced by the elastic net in order to obtain a smooth and clear prostate boundary in the classification result. (3) Residue-based linear regression is incorporated to improve the classification performance and to extend SRC from hard classification to soft classification. (4) Iterative SRC is proposed by using context information to iteratively refine the classification results. The proposed method has been comprehensively evaluated on a dataset consisting of 330 CT images from 24 patients. The effectiveness of the extended SRC has been validated by comparing it with the traditional SRC based on the proposed four extensions. The experimental results show that our extended SRC can obtain not only more accurate classification results but also smoother and clearer prostate boundary than the traditional SRC. Besides, the comparison with other five state-of-the-art prostate segmentation methods indicates that our method can achieve better performance than other methods under comparison. The authors have proposed a novel prostate segmentation method based on the sparse representation based classification, which can achieve considerably accurate segmentation results in CT prostate segmentation.

Finding the Right Touch: Extending the Right-Touch Regulation Approach to the Accreditation of Voluntary Registers

ERIC Educational Resources Information Center

Bilton, Douglas; Cayton, Harry

2013-01-01

What is "right-touch regulation"? In this article we explain why the Professional Standards Authority for Health and Social Care (the Authority) has focussed much of its policy work in recent times on seeking an answer to this question, and why it wants to know. We explain why the Authority's predecessor body, the Council for Healthcare…

Application Of The Iberdrola Licensing Methodology To The Cofrentes BWR-6 110% Extended Power Up-rate

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mata, Pedro; Fuente, Rafael de la; Iglesias, Javier

Iberdrola (spanish utility) and Iberdrola Ingenieria (engineering branch) have been developing during the last two years the 110% Extended Power Up-rate Project (EPU 110%) for Cofrentes BWR-6. IBERDROLA has available an in-house design and licensing reload methodology that has been approved by the Spanish Nuclear Regulatory Authority. This methodology has been already used to perform the nuclear design and the reload licensing analysis for Cofrentes cycles 12 to 14. The methodology has been also applied to develop a significant number of safety analysis of the Cofrentes Extended Power Up-rate including: Reactor Heat Balance, Core and Fuel performance, Thermal Hydraulic Stability,more » ECCS LOCA Evaluation, Transient Analysis, Anticipated Transient Without Scram (ATWS) and Station Blackout (SBO) Since the scope of the licensing process of the Cofrentes Extended Power Up-rate exceeds the range of analysis included in the Cofrentes generic reload licensing process, it has been required to extend the applicability of the Cofrentes licensing methodology to the analysis of new transients. This is the case of the TLFW transient. The content of this paper shows the benefits of having an in-house design and licensing methodology, and describes the process to extend the applicability of the methodology to the analysis of new transients. The case of analysis of Total Loss of Feedwater with the Cofrentes Retran Model is included as an example of this process. (authors)« less

77 FR 58323 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-20

... Aerospace LP (Type Certificate Previously Held by Israel Aircraft Industries, Ltd.) Airplanes AGENCY... Previously Held by Israel Aircraft Industries, Ltd.) Model Gulfstream G150 airplanes. This proposed AD was.... Discussion The Civil Aviation Authority of Israel (CAAI), which is the aviation authority for Israel, has...

Analysis of the potential for point-of-care test to enable individualised treatment of infections caused by antimicrobial-resistant and susceptible strains of Neisseria gonorrhoeae: a modelling study.

PubMed

Turner, Katy Me; Christensen, Hannah; Adams, Elisabeth J; McAdams, David; Fifer, Helen; McDonnell, Anthony; Woodford, Neil

2017-06-14

To create a mathematical model to investigate the treatment impact and economic implications of introducing an antimicrobial resistance point-of-care test (AMR POCT) for gonorrhoea as a way of extending the life of current last-line treatments. Modelling study. England. Patients accessing sexual health services. Incremental impact of introducing a hypothetical AMR POCT that could detect susceptibility to previous first-line antibiotics, for example, ciprofloxacin or penicillin, so that patients are given more tailored treatment, compared with the current situation where all patients are given therapy with ceftriaxone and azithromycin. The hypothetical intervention was assessed using a mathematical model developed in Excel. The model included initial and follow-up attendances, loss to follow-up, use of standard or tailored treatment, time taken to treatment and the costs of testing and treatment. Number of doses of ceftriaxone saved, mean time to most appropriate treatment, mean number of visits per (infected) patient, number of patients lost to follow-up and total cost of testing. In the current situation, an estimated 33 431 ceftriaxone treatments are administered annually and 792 gonococcal infections remain untreated due to loss to follow-up. The use of an AMR POCT for ciprofloxacin could reduce these ceftriaxone treatments by 66%, and for an AMR POCT for penicillin by 79%. The mean time for patients receiving an antibiotic treatment is reduced by 2 days in scenarios including POCT and no positive patients remain untreated through eliminating loss to follow-up. Such POCTs are estimated to add £34 million to testing costs, but this does not take into account reductions in costs of repeat attendances and the reuse of older, cheaper antimicrobials. The introduction of AMR POCT could allow clinicians to discern between the majority of gonorrhoea-positive patients with strains that could be treated with older, previously abandoned first-line treatments, and those requiring our current last-line dual therapy. Such tests could extend the useful life of dual ceftriaxone and azithromycin therapy, thus pushing back the time when gonorrhoea may become untreatable. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

34 CFR 380.5 - What activities may the Secretary fund under community-based supported employment projects?

Code of Federal Regulations, 2011 CFR

2011-07-01

... the Secretary fund under community-based supported employment projects? (a) Authorized activities. The following activities are authorized under community-based projects: (1) Job search assistance. (2) Job... Community-Based Supported Employment projects for the provision of extended supported employment services...

Young Children Manifest Spiritualities in Their Hip-Hop Writing

ERIC Educational Resources Information Center

Norton, Nadjwa E. L.

2014-01-01

In this article, the author combines multicultural feminist critical theories with the voices of Black and Latina/Latino young spiritual children to extend culturally responsive teaching. The author illuminates how children use their hip-hop writing to construct themselves as people who communicate with God, choose spiritual content for their…

75 FR 58329 - Federal Travel Regulation (FTR); Relocation Expenses Test Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-24

...; Docket 2010-0016; Sequence 1] RIN 3090-ZA01 Federal Travel Regulation (FTR); Relocation Expenses Test... extended the authority for relocation expenses test programs for Federal employees, made by the passage of..., permits the Administrator of General Services to authorize Federal agencies to test new and innovative...

47 CFR 76.986 - “A la carte” offerings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... an extended 120 day period (if the franchise authority has requested an additional 90 days) pursuant... to the Commission within 14 days of the initial decision. Operators shall provide notice to franchise... provide notice to franchise authorities of their decision to appeal to the Commission within this period...

47 CFR 76.986 - “A la carte” offerings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... an extended 120 day period (if the franchise authority has requested an additional 90 days) pursuant... to the Commission within 14 days of the initial decision. Operators shall provide notice to franchise... provide notice to franchise authorities of their decision to appeal to the Commission within this period...

47 CFR 76.986 - “A la carte” offerings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... an extended 120 day period (if the franchise authority has requested an additional 90 days) pursuant... to the Commission within 14 days of the initial decision. Operators shall provide notice to franchise... provide notice to franchise authorities of their decision to appeal to the Commission within this period...

47 CFR 76.986 - “A la carte” offerings.

Code of Federal Regulations, 2014 CFR

2014-10-01

... an extended 120 day period (if the franchise authority has requested an additional 90 days) pursuant... to the Commission within 14 days of the initial decision. Operators shall provide notice to franchise... provide notice to franchise authorities of their decision to appeal to the Commission within this period...

47 CFR 76.986 - “A la carte” offerings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... an extended 120 day period (if the franchise authority has requested an additional 90 days) pursuant... to the Commission within 14 days of the initial decision. Operators shall provide notice to franchise... provide notice to franchise authorities of their decision to appeal to the Commission within this period...

33 CFR 1.05-1 - Delegation of rulemaking authority.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Delegation of rulemaking... SECURITY GENERAL GENERAL PROVISIONS Rulemaking § 1.05-1 Delegation of rulemaking authority. (a) The... regulations. (2) This delegation does not extend to those matters specified in paragraph (c) of this section...

33 CFR 1.05-1 - Delegation of rulemaking authority.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Delegation of rulemaking... SECURITY GENERAL GENERAL PROVISIONS Rulemaking § 1.05-1 Delegation of rulemaking authority. (a) The... regulations. (2) This delegation does not extend to those matters specified in paragraph (c) of this section...

Our Changing Climate

ERIC Educational Resources Information Center

Newhouse, Kay Berglund

2007-01-01

In this article, the author discusses how global warming makes the leap from the headlines to the classroom with thought-provoking science experiments. To teach her fifth-grade students about climate change, the author starts with a discussion of the United States' local climate. They extend this idea to contrast the local climate with others,…

Architecture, Aesthetics, and Pluralism: Theories of Taste as a Determinant of Architectural Standards.

ERIC Educational Resources Information Center

Mann, Dennis Alan

1979-01-01

The author outlines and extends the description of "taste cultures" offered by Gans, indicating the aesthetic standards supported by different social classes in American society and suggesting how these standards operate in the form, content, composition, and contextual relationships of American architecture. (Author/SJL)

76 FR 21858 - Endangered and Threatened Species; Take of Anadromous Fish

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-19

... and Threatened Species; Take of Anadromous Fish AGENCY: National Marine Fisheries Service (NMFS... and policy of section 2 of the ESA. The authority to take listed species is subject to conditions set... extend their 2-year scientific research permit that currently authorizes them to take juvenile and adult...

Soul Music: Techniques for Therapeutic Intervention

ERIC Educational Resources Information Center

Toldson, Ivory L.; Pasteur, Alfred B.

1972-01-01

The authors conclude that using black music in the educational process aligns educational input with black culture. This approach, which extends and utilizes the spiritual dimension of black life, is consistent with the black value system and can help black learners integrate and internalize an aspect of their cultural heritage. (Author/BY)

Contributions of Attentional Style and Previous Experience to 4-Month-Old Infants' Categorization

ERIC Educational Resources Information Center

Kovack-Lesh, Kristine A.; Oakes, Lisa M.; McMurray, Bob

2012-01-01

We examined how infants' categorization is jointly influenced by previous experience and how much they shift their gaze back and forth between stimuli. Extending previous findings reported by K. A. Kovack-Lesh, J. S. Horst, and L. M. Oakes (2008), we found that 4-month-old infants' (N = 122) learning of the exclusive category of "cats" was related…

Extended radio emission and the nature of blazars

NASA Astrophysics Data System (ADS)

Antonucci, R. R. J.; Ulvestad, J. S.

1985-07-01

The VLA has been used at 20 cm to map all 23 of the 54 confirmed blazars listed in the Angel and Stockman review paper that had not been mapped before at high resolution. In addition, data on most of the previously mapped blazars have been reprocessed in order to achieve higher dynamic range. Extended emission has been detected associated with 49 of the 54 objects. The extended radio emission has been used to test the hypothesis that blazars are normal radio galaxies and radio quasars viewed along the jet axes. It is found that blazars have substantial extended power, consistent with this hypothesis. The ratio of core to extended radio emission has been studied as a possible indicator of viewing aspect or beaming intensity.

Personality and Academic Motivation: Replication, Extension, and Replication

ERIC Educational Resources Information Center

Jones, Martin H.; McMichael, Stephanie N.

2015-01-01

Previous work examines the relationships between personality traits and intrinsic/extrinsic motivation. We replicate and extend previous work to examine how personality may relate to achievement goals, efficacious beliefs, and mindset about intelligence. Approximately 200 undergraduates responded to the survey with a 150 participants replicating…

Special Theme Section--Representation and Blindness: The Effect of Extended Acoustic Training on Spatial Updating in Adults Who Are Congenitally Blind.

ERIC Educational Resources Information Center

Easton, Randolph D.; Bentzen, Billie Louise

1999-01-01

A study, including research and practice notes by various authors, investigated whether extended training in an acoustically rich environment could enhance the spatial updating ability of 12 adults with congenital blindness. After training, the adults' distance perception from a home-base location and novel locations was superior to a sighted…

Perspectives on Extended Family and Fictive Kin in the Later Years: Strategies and Meanings of Kin Reinterpretation

ERIC Educational Resources Information Center

Allen, Katherine R.; Blieszner, Rosemary; Roberto, Karen A.

2011-01-01

To identify perspectives on the roles of extended family and fictive kin, the authors conducted a qualitative analysis of in-depth interviews with 45 older adults diverse in gender, race, and class. Five strategies of kin reinterpretation were found. Kin promotion defined a distant blood relative as a closer blood relative. Kin exchange…

Open Group Transformations

NASA Astrophysics Data System (ADS)

Batalin, Igor; Marnelius, Robert

Open groups whose generators are in arbitrary involutions may be quantized within a ghost extended framework in terms of a nilpotent BFV-BRST charge operator. Previously we have shown that generalized quantum Maurer-Cartan equations for arbitrary open groups may be extracted from the quantum connection operators and that they also follow from a simple quantum master equation involving an extended nilpotent BFV-BRST charge and a master charge. Here we give further details of these results. In addition we establish the general structure of the solutions of the quantum master equation. We also construct an extended formulation whose properties are determined by the extended BRST charge in the master equation.

Massive Open Online Course Completion Rates Revisited: Assessment, Length and Attrition

ERIC Educational Resources Information Center

Jordan, Katy

2015-01-01

This analysis is based upon enrolment and completion data collected for a total of 221 Massive Open Online Courses (MOOCs). It extends previously reported work (Jordan, 2014) with an expanded dataset; the original work is extended to include a multiple regression analysis of factors that affect completion rates and analysis of attrition rates…

Using the Extended Parallel Process Model to Examine Teachers' Likelihood of Intervening in Bullying

ERIC Educational Resources Information Center

Duong, Jeffrey; Bradshaw, Catherine P.

2013-01-01

Background: Teachers play a critical role in protecting students from harm in schools, but little is known about their attitudes toward addressing problems like bullying. Previous studies have rarely used theoretical frameworks, making it difficult to advance this area of research. Using the Extended Parallel Process Model (EPPM), we examined the…

A parametric study of the drift-tearing mode using an extended-magnetohydrodynamic model

DOE PAGES

King, Jacob R.; Kruger, S. E.

2014-10-24

The linear, collisional, constant-ψ drift-tearing mode is analyzed for different regimes of the plasma-β, ion-skin-depth parameter space with an unreduced, extended-magnetohydrodynamic model. Here, new dispersion relations are found at moderate plasma β and previous drift-tearing results are classified as applicable at small plasma β.

The culture ready brain

PubMed Central

2010-01-01

In this article, I examine two hypotheses of language origins: the extended mirror system hypothesis and the vocal grooming hypothesis. These conflict in several respects, partly because their authors were trained in different disciplines and influenced by different kinds of evidence. I note some ethnographic/linguistic and psychological issues which, in my view, have not been sufficiently considered by these authors, and present a ‘play and display’ hypothesis which aims to explain the evolution, not of language, but of the ‘culture ready brain’—with apologies to Arbib for so extending his original concept. In the second half of the article, I will test all three hypotheses against the available fossil, archaeological and neuroimaging evidence. PMID:20558409

Extension of the Expiration Date for State Disability Examiner Authority To Make Fully Favorable Quick Disability Determinations and Compassionate Allowance Determinations. Final rule.

PubMed

2016-10-24

We are extending, until December 28, 2018, the expiration date of our disability examiner authority (DEA) rule, which authorizes State agency disability examiners to make fully favorable determinations without the approval of a State agency medical or psychological consultant in claims that we consider under our quick disability determination (QDD) and compassionate allowance (CAL) processes. This is our last extension of this rule because we will phase out the use of DEA during the extension period under section 832 of the Bipartisan Budget Act of 2015 (BBA). This extension provides us the time necessary to take all of the administrative actions we need to take in order to reinstate uniform use of medical and psychological consultants. The current rule will expire on November 11, 2016. In this final rule, we are changing the November 11, 2016 expiration or "sunset" date to December 28, 2018, extending the authority for 2 years and 1 month. This is the final extension of our DEA rule. On December 28, 2018, at the conclusion of this extension, the authority for this test will terminate. We are making no other changes.

Viscoelastic properties of three vocal-fold injectable biomaterials at low audio frequencies.

PubMed

Klemuk, Sarah A; Titze, Ingo R

2004-09-01

Previous measurements of viscoelastic properties of Zyderm were to be extended to low audio frequencies, and properties of two other biomaterials not previously measured, thiolated hyaluronic acid (HA-DTPH) and Cymetra, were obtained. Rheologic investigation. Oscillatory shear stress was applied to each sample using a controlled stress rheometer at frequencies between 0.01 and 100 Hz with a parallel plate apparatus. Versuscoelastic moduli were recorded at each frequency. The calculated resonance frequency of the machine and sample were then used to determine the maximum frequency at which reliable data existed. Extrapolation functions were fit to viscoelastic parameters, which predicted the properties up to 1,000 Hz. Frequency trends of Zyderm were similar to those previously reported, whereas magnitudes were different. The elastic moduli logarithmically increased with frequency, whereas dynamic viscosity demonstrated shear thinning, a condition of primary importance for humans to vocalize over a broad frequency range. Previous measurements were extended from 15 Hz up to 74 Hz. Differences in magnitude between a previous study and the present study were attributed to particulate orientation during testing. Cymetra was found to have nearly identical viscoelastic properties to those of bovine collagen, both in magnitude and frequency trend, with reliable measures extending up to 81 Hz. Rheologic properties of the hyaluronic acid gel were the closest match to cadaveric vocal fold mucosa in magnitude and frequency trend. Viscoelastic properties of Cymetra and Zyderm are nearly the same and are significantly greater than those of vocal fold mucosa. HA-DTPH possesses a good viscoelastic match to vocal fold mucosa and may be useful in future lamina propria repair.

Evaluation of Flexible Tacrolimus Drug Concentration Monitoring Approach in Patients Receiving Extended-Release Once-Daily Tacrolimus Tablets.

PubMed

Philosophe, Benjamin; Leca, Nicolae; West-Thielke, Patricia M; Horwedel, Timothy; Culkin-Gemmell, Christine; Kistler, Kristin; Stevens, Daniel R

2018-02-20

The majority of United States kidney transplant patients are treated with tacrolimus, a drug effective in preventing graft rejection, but with a narrow therapeutic range, necessitating close monitoring to avoid increased risks of transplant rejection or toxicity if the tacrolimus concentration is too low or too high, respectively. The trough drug concentration tests are time sensitive; patients treated on a twice-daily basis have blood draws exactly 12 hours after their previous dose. The schedule's rigidity causes problems for both patients and health care providers. Novel once-daily tacrolimus formulations such as LCPT (an extended-release tablet by Veloxis Pharmaceuticals, Inc., Cary, North Carolina) have allowed for blood draws on a once-daily basis; however, even that schedule can be restrictive. Results from tests taken either before or after that 24-hour target time may be discarded, or worse, may lead to inappropriate dose changes. Data from ASTCOFF, a phase 3B pharmacokinetic clinical trial (NCT02339246), demonstrated that the unique pharmacokinetic curve of LCPT may allow for a therapeutic monitoring window that extends for 3 hours before or after the 24-hour monitoring target. Furthermore, important tools to help clinicians interpret these levels, such as formulas to estimate the 24-hour trough level if an alternative monitoring time is used, were constructed from these data. These study results give treating clinicians access to data that allow them to safely use and monitor LCPT in their patients and expand the body of evidence surrounding differentiation and practical application of the novel LCPT tacrolimus formulation. © 2018, The Authors. The Journal of Clinical Pharmacology published by Wiley Periodicals, Inc. on behalf of American College of Clinical Pharmacology.

Extending the Framework of Generativity Theory Through Research: A Qualitative Study.

PubMed

Rubinstein, Robert L; Girling, Laura M; de Medeiros, Kate; Brazda, Michael; Hannum, Susan

2015-08-01

Based on ethnographic interviews, we discuss three ideas we believe will expand knowledge of older informants' thoughts about and representations of generativity. We adapt the notion of "dividuality" as developed in cultural anthropology to reframe ideas on generativity. The term dividuality refers to a condition of interpersonal or intergenerational connectedness, as distinct from individuality. We also extend previous definitions of generativity by identifying both objects of generative action and temporal and relational frameworks for generative action. We define 4 foci of generativity (people, groups, things, and activities) and 4 spheres of generativity (historical, familial, individual, and relational) based in American culture and with which older informants could easily identify. The approach outlined here also discusses a form of generativity oriented to the past in which relationships with persons in senior generations form a kind of generative action since they are involved in caring for the origins of the self and hence of future generative acts. These 3 elements of a new framework will allow researchers to pose critical questions about generativity among older adults. Such questions include (a) How is the self, as culturally constituted, involved in generative action? and (b) What are the types of generativity within the context of American culture and how are they spoken about? Each of the above points is directly addressed in the data we present below. We defined these domains through extended ethnographic interviews with 200 older women. The article addresses some new ways of thinking about generativity as a construct, which may be useful in understanding the cultural personhood of older Americans. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Productivity trends and collaboration patterns: A diachronic study in the eating disorders field

PubMed Central

Valderrama-Zurián, Juan-Carlos; Aguilar-Moya, Remedios; Cepeda-Benito, Antonio; Navarro-Moreno, María-Ángeles; Gandía-Balaguer, Asunción; Aleixandre-Benavent, Rafael

2017-01-01

Objective The present study seeks to extend previous bibliometric studies on eating disorders (EDs) by including a time-dependent analysis of the growth and evolution of multi-author collaborations and their correlation with ED publication trends from 1980 to 2014 (35 years). Methods Using standardized practices, we searched Web of Science (WoS) Core Collection (WoSCC) (indexes: Science Citation Index-Expanded [SCIE], & Social Science Citation Index [SSCI]) and Scopus (areas: Health Sciences, Life Sciences, & Social Sciences and Humanities) to identify a large sample of articles related to EDs. We then submitted our sample of articles to bibliometric and graph theory analyses to identify co-authorship and social network patterns. Results We present a large number of detailed findings, including a clear pattern of scientific growth measured as number of publications per five-year period or quinquennium (Q), a tremendous increase in the number of authors attracted by the ED subject, and a very high and steady growth in collaborative work. Conclusions We inferred that the noted publication growth was likely driven by the noted increase in the number of new authors per Q. Social network analyses suggested that collaborations within ED follow patters of interaction that are similar to well established and recognized disciplines, as indicated by the presence of a “giant cluster”, high cluster density, and the replication of the “small world” phenomenon—the principle that we are all linked by short chains of acquaintances. PMID:28850569

Developing Academic Strategic Alliances: Reconciling Multiple Institutional Cultures, Policies, and Practices

ERIC Educational Resources Information Center

Eckel, Peter D.; Hartley, Matthew

2008-01-01

Interorganizational relationships (IORs), according to these authors, represent a promising means for developing new capacities in the creation of strategic partnerships between colleges and universities. In this study, the authors focus on academic IORs that are strategic in nature (i.e., they extend beyond the mere sharing of library books or…

Democracy Is Little "l" Leadership: For Every Day at Any Time

ERIC Educational Resources Information Center

Bogotch, Ira

2011-01-01

This article directs to the Dialogues of Leadership Education section of "Scholar-Practitioner Quarterly," Volume 4, Issue 4, wherein the contributing authors examined the question of priorities of leadership education for a democratic society. In this article, the author extends that earlier dialogue, and draws into specific relief the language…

76 FR 18216 - Southern Natural Gas Company; Notice of Request Under Blanket Authorization

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-01

... Natural Gas Company; Notice of Request Under Blanket Authorization Take notice that on March 16, 2011, Southern Natural Gas Company (Southern), Post Office Box 2563, Birmingham, Alabama 35202-2563, filed in... Regulations under the Natural Gas Act (NGA) as amended, to abandon in place a supply lateral that extends from...

Bridge over Black[ened] Water: A New Refrain for NGOs

ERIC Educational Resources Information Center

Ginsburg, Mark

2008-01-01

This author feels that how one views NGOs (non-government organizations) depends on one's perspective, and thus his reflections in this article focus more on extending his earlier analysis, rather than revising it. The author does this by considering three relatively recent developments, which in different ways have provoked him to keep wrestling…

Tasseography: Reading Post-Racial Resistance to Teaching

ERIC Educational Resources Information Center

Houston, Akil

2011-01-01

This article focuses on developing a progressive philosophy of praxis that challenges, what the author argues is, a post-racial resistance to teaching about racial injustice. Post-racial resistance to teaching can lead to forms of enlightened racism and sexism in the classroom. In this essay, the author develops and extends the use of the metaphor…

77 FR 5084 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-01

... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-66254; File No. SR-FINRA-2012-005] Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Extend the Pilot Period of Amendments to FINRA Rule 11892 Governing Clearly Erroneous Transactions January 26,...

77 FR 75627 - Commission Information Collection Activities (FERC-538); Comment Request; Extension

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-21

... municipality authorized to engage in the local distribution of natural gas, the Commission may order a natural gas company to extend or improve its transportation facilities, and sell natural gas to the... authorized to engage in the local distribution of natural gas. Estimate of Annual Burden: \\2\\ The Commission...

The Practice Set: A New Spin on an Old Idea

ERIC Educational Resources Information Center

Savage, Helen M.; Law, David B.

2003-01-01

In this article, the authors describe their experience in extending a manual practice set to accounting software. The "Systems Understanding Aid" by Arens and Ward (2001) has been used for some time in the authors' Accounting Information Systems course. The extension involved requiring students to redo the project using Peachtree Complete…

Shared decision-making for people living with dementia in extended care settings: a systematic review.

PubMed

Daly, Rachel Louise; Bunn, Frances; Goodman, Claire

2018-06-09

Shared decision-making is recognised as an important element of person-centred dementia care. The aim of this review was to explore how people living with dementia and cognitive impairment can be included in day-to-day decisions about their health and care in extended care settings. A systematic review including primary research relating to shared decision-making, with cognitively impaired adults in (or transferrable to) extended care settings. Databases searched were: CINAHL, PubMed, the Cochrane Library, NICE Evidence, OpenGrey, Autism Data, Google Scholar, Scopus and Medicines Complete (June to October 2016 and updated 2018) for studies published in the last 20 years. Of the 19 included studies 15 involved people with living dementia, seven in extended care settings. People living with cognitive impairment often have the desire and ability to participate in decision-making about their everyday care, although this is regularly underestimated by their staff and family care partners. Shared decision-making has the potential to improve quality of life for both the person living with dementia and those who support them. How resources to support shared decision-making are implemented in extended care settings is less well understood. Evidence suggests that people living with cognitive impairment value opportunities to be involved in everyday decision-making about their care. How these opportunities are created, understood, supported and sustained in extended care settings remains to be determined. CRD42016035919. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Cognitive demand of human sensorimotor performance during an extended space mission: a dual-task study.

PubMed

Bock, Otmar; Weigelt, Cornelia; Bloomberg, Jacob J

2010-09-01

Two previous single-case studies found that the dual-task costs of manual tracking plus memory search increased during a space mission, and concluded that sensorimotor deficits during spaceflight may be related to cognitive overload. Since dual-task costs were insensitive to the difficulty of memory search, the authors argued that the overload may reflect stress-related problems of multitasking, rather than a scarcity of specific cognitive resources. Here we expand the available database and compare different types of concurrent task. Three subjects were repeatedly tested before, during, and after an extended mission on the International Space Station (ISS). They performed an unstable tracking task and four reaction-time tasks, both separately and concurrently. Inflight data could only be obtained during later parts of the mission. The tracking error increased from pre- to in flight by a factor of about 2, both under single- and dual-task conditions. The dual-task costs with a reaction-time task requiring rhythm production was 2.4 times higher than with a reaction-time task requiring visuo-spatial transformations, and 8 times higher than with a regular choice reaction-time task. Long-term sensorimotor deficits during spaceflight may reflect not only stress, but also a scarcity of resources related to complex motor programming; possibly those resources are tied up by sensorimotor adaptation to the space environment.

Evolving beta-lactamase epidemiology in Enterobacteriaceae from Italian nationwide surveillance, October 2013: KPC-carbapenemase spreading among outpatients.

PubMed

Giani, Tommaso; Antonelli, Alberto; Caltagirone, Mariasofia; Mauri, Carola; Nicchi, Jessica; Arena, Fabio; Nucleo, Elisabetta; Bracco, Silvia; Pantosti, Annalisa; Luzzaro, Francesco; Pagani, Laura; Rossolini, Gian Maria

2017-08-03

Extended-spectrum beta-lactamases (ESBLs), AmpC-type beta-lactamases (ACBLs) and carbapenemases are among the most important resistance mechanisms in Enterobacteriaceae. This study investigated the presence of these resistance mechanisms in consecutive non-replicate isolates of Escherichia coli (n = 2,352), Klebsiella pneumoniae (n = 697), and Proteus mirabilis (n = 275) from an Italian nationwide cross-sectional survey carried out in October 2013. Overall, 15.3% of isolates were non-susceptible to extended-spectrum cephalosporins but susceptible to carbapenems (ESCR-carbaS), while 4.3% were also non-susceptible to carbapenems (ESCR-carbaR). ESCR-carbaS isolates were contributed by all three species, with higher proportions among isolates from inpatients (20.3%) but remarkable proportions also among those from outpatients (11.1%). Most ESCR-carbaS isolates were ESBL-positive (90.5%), and most of them were contributed by E. coli carrying bla CTX-M group 1 genes. Acquired ACBLs were less common and mostly detected in P. mirabilis. ESCR-carbaR isolates were mostly contributed by K. pneumoniae (25.1% and 7.7% among K. pneumoniae isolates from inpatients and outpatients, respectively), with bla KPC as the most common carbapenemase gene. Results showed an increasing trend for both ESBL and carbapenemase producers in comparison with previous Italian surveys, also among outpatients. This article is copyright of The Authors, 2017.

Influence of resveratrol on oxidative stress resistance and life span in Caenorhabditis elegans.

PubMed

Chen, Wei; Rezaizadehnajafi, Leila; Wink, Michael

2013-05-01

Resveratrol (3,5,4'-trihydroxy-trans-stilbene), a polyphenol from red wine, has been reported to be beneficial in cases of ageing-related cardiovascular and neurodegenerative diseases owing to its property to reduce oxidative stress. Previous studies on the longevity promoting effect of resveratrol have been partly inconclusive, therefore we set out to investigate whether resveratrol at least promoted longevity in Caenorhabditis elegans under acute oxidative stress conditions. C. elegans was cultured under standard conditions with or without resveratrol. After exposure to juglone-induced acute oxidative stress, the survival rate and hsp-16.2::GFP expression were measured. The influence of resveratrol on life span was recorded also under oxidative stress induced by high glucose concentrations in the growth medium. No extension of the normal life span of C. elegans was observed either in liquid or solid growth media containing different concentrations of resveratrol. However, resveratrol alleviated juglone-induced lethal oxidative stress, and significantly prolonged the life span of C. elegans under conditions of acute oxidative damage and oxidative stress caused by high concentrations of glucose. Resveratrol, as an antioxidant, ameliorated oxidative stress in vivo but did not extend the life span of C. elegans under normal conditions. However, resveratrol did extend life span under conditions of oxidative stress. © 2013 The Authors. JPP © 2013 Royal Pharmaceutical Society.

Quantitative determination of occupation sites of trace Co substituted for multiple Fe sites in M-type hexagonal ferrite using statistical beam-rocking TEM-EDXS analysis.

PubMed

Ohtsuka, Masahiro; Muto, Shunsuke; Tatsumi, Kazuyoshi; Kobayashi, Yoshinori; Kawata, Tsunehiro

2016-04-01

The occupation sites and the occupancies of trace dopants in La/Co co-doped Sr-M-type ferrite, SrFe12O19, were quantitatively and precisely determined by beam-rocking energy-dispersive X-ray spectroscopy (EDXS) on the basis of electron-channeling effects. Because the Co atoms, in particular, should be partially substituted for the five crystallographically inequivalent sites, which could be key parameters in improving the magneto-crystalline anisotropy, it is difficult yet intriguing to discover their occupation sites and occupancies without using the methods of large-scale facilities, such as neutron diffraction and synchrotron radiation. In the present study, we tackled this problem by applying an extended statistical atom location by channeling enhanced microanalysis method, using conventional transmission electron microscopy, EDXS and dynamical electron elastic/inelastic scattering theories. The results show that the key occupation sites of Co were the 2a, 4f1 and 12k sites. The quantified occupancies of Co were consistent with those of the previous study, which involved a combination of neutron diffraction and extended X-ray absorption fine structure analysis, as well as energetics considerations based on by first-principles calculations. © The Author 2015. Published by Oxford University Press on behalf of The Japanese Society of Microscopy. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Valence-specific conflict moderation in the dorso-medial PFC and the caudate head in emotional speech.

PubMed

Kotz, Sonja A; Dengler, Reinhard; Wittfoth, Matthias

2015-02-01

Emotional speech comprises of complex multimodal verbal and non-verbal information that allows deducting others' emotional states or thoughts in social interactions. While the neural correlates of verbal and non-verbal aspects and their interaction in emotional speech have been identified, there is very little evidence on how we perceive and resolve incongruity in emotional speech, and whether such incongruity extends to current concepts of task-specific prediction errors as a consequence of unexpected action outcomes ('negative surprise'). Here, we explored this possibility while participants listened to congruent and incongruent angry, happy or neutral utterances and categorized the expressed emotions by their verbal (semantic) content. Results reveal valence-specific incongruity effects: negative verbal content expressed in a happy tone of voice increased activation in the dorso-medial prefrontal cortex (dmPFC) extending its role from conflict moderation to appraisal of valence-specific conflict in emotional speech. Conversely, the caudate head bilaterally responded selectively to positive verbal content expressed in an angry tone of voice broadening previous accounts of the caudate head in linguistic control to moderating valence-specific control in emotional speech. Together, these results suggest that control structures of the human brain (dmPFC and subcompartments of the basal ganglia) impact emotional speech differentially when conflict arises. © The Author (2014). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

Snake fangs: 3D morphological and mechanical analysis by microCT, simulation, and physical compression testing.

PubMed

du Plessis, Anton; Broeckhoven, Chris; le Roux, Stephan G

2018-01-01

This Data Note provides data from an experimental campaign to analyse the detailed internal and external morphology and mechanical properties of venomous snake fangs. The aim of the experimental campaign was to investigate the evolutionary development of 3 fang phenotypes and investigate their mechanical behaviour. The study involved the use of load simulations to compare maximum Von Mises stress values when a load is applied to the tip of the fang. The conclusions of this study have been published elsewhere, but in this data note we extend the analysis, providing morphological comparisons including details such as curvature comparisons, thickness, etc. Physical compression results of individual fangs, though reported in the original paper, were also extended here by calculating the effective elastic modulus of the entire snake fang structure including internal cavities for the first time. This elastic modulus of the entire fang is significantly lower than the locally measured values previously reported from indentation experiments, highlighting the possibility that the elastic modulus is higher on the surface than in the rest of the material. The micro-computed tomography (microCT) data are presented both in image stacks and in the form of STL files, which simplifies the handling of the data and allows its re-use for future morphological studies. These fangs might also serve as bio-inspiration for future hypodermic needles. © The Author 2017. Published by Oxford University Press.

SPECTRAL CORRECTION FACTORS FOR CONVENTIONAL NEUTRON DOSE METERS USED IN HIGH-ENERGY NEUTRON ENVIRONMENTS-IMPROVED AND EXTENDED RESULTS BASED ON A COMPLETE SURVEY OF ALL NEUTRON SPECTRA IN IAEA-TRS-403.

PubMed

Oparaji, U; Tsai, Y H; Liu, Y C; Lee, K W; Patelli, E; Sheu, R J

2017-06-01

This paper presents improved and extended results of our previous study on corrections for conventional neutron dose meters used in environments with high-energy neutrons (En > 10 MeV). Conventional moderated-type neutron dose meters tend to underestimate the dose contribution of high-energy neutrons because of the opposite trends of dose conversion coefficients and detection efficiencies as the neutron energy increases. A practical correction scheme was proposed based on analysis of hundreds of neutron spectra in the IAEA-TRS-403 report. By comparing 252Cf-calibrated dose responses with reference values derived from fluence-to-dose conversion coefficients, this study provides recommendations for neutron field characterization and the corresponding dose correction factors. Further sensitivity studies confirm the appropriateness of the proposed scheme and indicate that (1) the spectral correction factors are nearly independent of the selection of three commonly used calibration sources: 252Cf, 241Am-Be and 239Pu-Be; (2) the derived correction factors for Bonner spheres of various sizes (6"-9") are similar in trend and (3) practical high-energy neutron indexes based on measurements can be established to facilitate the application of these correction factors in workplaces. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

More Time for Learning: Student Participation in Extended Day Programming at the UCCS Donoghue Campus during the 2009-10 School Year

ERIC Educational Resources Information Center

Lesnick, Joy; Hart, Bonnie; Spielberger, Julie

2011-01-01

The purpose of this study was to examine the participation of students in extended day programming at Donoghue Elementary School, a University of Chicago Charter School, during the 2009-2010 school year and explore whether participation was related to academic performance and improvement. Using the available written records, the authors found that…

Forecasting Three-Month Outcomes in a Laboratory School Comparison of Mixed Amphetamine Salts Extended Release (Adderall XR) and Atomoxetine (Strattera) in School-Aged Children with ADHD

ERIC Educational Resources Information Center

Faraone, Stephen V.; Wigal, Sharon B.; Hodgkins, Paul

2007-01-01

Objective: Compare observed and forecasted efficacy of mixed amphetamine salts extended release (MAS-XR; Adderall) with atomoxetine (Strattera) in ADHD children. Method: The authors analyze data from a randomized, double-blind, multicenter, parallel-group, forced-dose-escalation laboratory school study of children ages 6 to 12 with ADHD combined…

Effect of retinal defocus on basketball free throw shooting performance.

PubMed

Bulson, Ryan C; Ciuffreda, Kenneth J; Hayes, John; Ludlam, Diana P

2015-07-01

Vision plays a critical role in athletic performance; however, previous studies have demonstrated that a variety of simulated athletic sensorimotor tasks can be surprisingly resilient to retinal defocus (blurred vision). The purpose of the present study was to extend this work to determine the effect of retinal defocus on overall basketball free throw performance, as well as for the factors gender, refractive error and experience. Forty-four young adult participants of both genders were recruited. They had a range of refractive errors and basketball experience. Each performed 20 standard basketball free throws under five lens defocus conditions in a randomised manner: plano, +1.50 D, +3.00 D, +4.50 D and +10.00 D. Overall, free throw performance was significantly reduced under the +10.00 D lens defocus condition only. Previous experience, but neither refractive error nor gender, yielded a statistically significant difference in performance. Consistent with previous studies of complex sensorimotor tasks, basketball free throw performance was resilient to low and moderate levels of retinal defocus. Thus, for a relatively non-dynamic motor task at a fixed far distance, such as the basketball free throw, precise visual clarity was not critical. Other factors such as motor memory may be important. However, in the dynamic athletic competitive environment it is likely that visual clarity plays a more critical role in one's performance level, at least for specific task demands. © 2015 The Authors. Clinical and Experimental Optometry © 2015 Optometry Australia.

Weighted bi-prediction for light field image coding

NASA Astrophysics Data System (ADS)

Conti, Caroline; Nunes, Paulo; Ducla Soares, Luís.

2017-09-01

Light field imaging based on a single-tier camera equipped with a microlens array - also known as integral, holoscopic, and plenoptic imaging - has currently risen up as a practical and prospective approach for future visual applications and services. However, successfully deploying actual light field imaging applications and services will require developing adequate coding solutions to efficiently handle the massive amount of data involved in these systems. In this context, self-similarity compensated prediction is a non-local spatial prediction scheme based on block matching that has been shown to achieve high efficiency for light field image coding based on the High Efficiency Video Coding (HEVC) standard. As previously shown by the authors, this is possible by simply averaging two predictor blocks that are jointly estimated from a causal search window in the current frame itself, referred to as self-similarity bi-prediction. However, theoretical analyses for motion compensated bi-prediction have suggested that it is still possible to achieve further rate-distortion performance improvements by adaptively estimating the weighting coefficients of the two predictor blocks. Therefore, this paper presents a comprehensive study of the rate-distortion performance for HEVC-based light field image coding when using different sets of weighting coefficients for self-similarity bi-prediction. Experimental results demonstrate that it is possible to extend the previous theoretical conclusions to light field image coding and show that the proposed adaptive weighting coefficient selection leads to up to 5 % of bit savings compared to the previous self-similarity bi-prediction scheme.

Studies of extra-solar Oort Clouds and the Kuiper disk

NASA Technical Reports Server (NTRS)

Stern, S. Alan

1992-01-01

In 1991 we detected extended 1.1 mm emission around Fomalhaut (alpha PsA) at distances in order of magnitude beyond previous detections. This emission is plausibly related to the presence of an extended comet cloud, like our Oort Cloud, and may therefore represent indirect evidence for the formation of a planetary system at Fomalhaut. We propose now to extend this work to create a map of the angular and spatial extent of this emission. Fomalhaut is the only known main-sequence, submm-resolved IR excess source besides beta Pic.

Examining Associations among ADHD, Homework Behavior, and Reading Comprehension: A Twin Study

ERIC Educational Resources Information Center

Little, Callie W.; Hart, Sara A.; Schatschneider, Christopher; Taylor, Jeanette

2016-01-01

Previous literature has indicated an important association between reading comprehension and both attention-deficit/hyperactivity disorder (ADHD) and homework habits. This investigation sought to extend previous knowledge by providing information about how ADHD and homework behavior (i.e., completing homework regularly) may jointly influence…

Life Satisfaction and Happiness in Turkey

ERIC Educational Resources Information Center

Selim, Sibel

2008-01-01

This research aims to investigate life satisfaction and happiness in Turkey. It extends the previous researches on subjective well-being (SWB) for Turkey by considering both happiness and life satisfaction. The previous researches for Turkey are local studies, and their findings cannot be generalized to the population of Turkish society. Given…

Extended Fenske-Hall LCAO MO Calculations for Mixed Methylene Dihalides

NASA Astrophysics Data System (ADS)

Ziemann, Hartmut; Paulun, Manfred

1988-10-01

The electronic structure of mixed methylene dihalides CH2XY (X, Y = F, Cl, Br. I) has been studied using extended Fenske-Hall LCAO MO method. The comparison with available photoelec­tron spectra confirmes previous assignments of all bands with binding energies <100 eV. The electronic structure changes occurring upon varying the halogen substituents are discussed.

Time to Tenure: Does Tenure Reform Affect Teacher Absence Behavior and Mobility? Working Paper 172

ERIC Educational Resources Information Center

Goldhaber, Dan; Hansen, Michael; Walch, Joe

2016-01-01

We rely on natural experiments in North Carolina and Washington State, which previously extended time to tenure by one year, to estimate models that assess the relationship between the extended probationary period and absence and attrition outcomes for teachers affected by the new tenure laws. Across both states we find evidence of decreases in…

Aerodynamic Characteristics of Three Deep-Stepped Planing-Tail Flying-Boat Hulls

NASA Technical Reports Server (NTRS)

Riebe, John M.; Naeseth, Rodger L.

1947-01-01

An investigation was made in the Langley 300 MPH 7- by 10-foot tunnel to determine the aerodynamic characteristics of three deep-stepped planing-tail flying-boat hulls differing only in the amount of step fairing. The hulls were derived by increasing the unfaired step depth of a planing-tail hull of a previous aerodynamic investigation to a depth about 92 percent of the hull beam. Tests were also made on a transverse-stepped hull with an extended afterbody for the purpose of comparison and in order to extend and verify the results of a previous investigation. The investigation indicated that the extended afterbody hull had a minimum drag coefficient about the same as a conventional hull, 0.0066, and an angle-of-attack range for minimum drag coefficient of 0.0057 which was 14 percent less than the transverse stepped hull with extended afterbody; the hulls with step fairing had up to 44 percent less minimum drag coefficient than the transverse-stepped hull, or slightly more drag than a streamlined body having approximately the same length and volume. Longitudinal and lateral instability varied little with step fairing and was about the same as a conventional hull.

Open Group Transformations Within the Sp(2)-Formalism

NASA Astrophysics Data System (ADS)

Batalin, Igor; Marnelius, Robert

Previously we have shown that open groups whose generators are in arbitrary involutions may be quantized within a ghost extended framework in terms of the nilpotent BFV-BRST charge operator. Here we show that they may also be quantized within an Sp(2)-frame in which there are two odd anticommuting operators called Sp(2)-charges. Previous results for finite open group transformations are generalized to the Sp(2)-formalism. We show that in order to define open group transformations on the whole ghost extended space we need Sp(2)-charges in the nonminimal sector which contains dynamical Lagrange multipliers. We give an Sp(2)-version of the quantum master equation with extended Sp(2)-charges and a master charge of a more involved form, which is proposed to represent the integrability conditions of defining operators of connection operators and which therefore should encode the generalized quantum Maurer-Cartan equations for arbitrary open groups. General solutions of this master equation are given in explicit form. A further extended Sp(2)-formalism is proposed in which the group parameters are quadrupled to a supersymmetric set and from which all results may be derived.

Collective stories and well-being: using a dialogical narrative approach to understand peer relationships among combat veterans experiencing post-traumatic stress disorder.

PubMed

Caddick, Nick; Phoenix, Cassandra; Smith, Brett

2015-03-01

Using a dialogical narrative approach, this original research explored how combat veterans experiencing post-traumatic stress disorder made sense of peer relationships with other veterans and what effects these relationships had on their well-being. Interviews and participant observations were conducted with 15 male combat veterans (aged 27-60 years) and one member of the civilian emergency services, the majority of whom were diagnosed with post-traumatic stress disorder following traumatic exposure in a range of armed conflicts. All participants were part of a surfing charity for veterans experiencing post-traumatic stress disorder. Data were rigorously analysed using a dialogical narrative analysis (DNA). Findings revealed the collective story that veterans used to make sense of peer relationships within the group. This collective story worked for the veterans to shape their experiences of well-being by fostering camaraderie, stimulating deeper connections and countering the negative effects of post-traumatic stress disorder. Potential therapeutic effects of the collective story were also identified. This article extends previous knowledge on combat veterans and social relationships and advances the field of narrative health psychology through the empirical application of a sophisticated dialogical narrative approach. © The Author(s) 2015.

What results when firms implement practices: the differential relationship between specific practices, firm financial performance, customer service, and quality.

PubMed

Gibson, Cristina B; Porath, Christine L; Benson, George S; Lawler, Edward E

2007-11-01

Previous research on organizational practices is replete with contradictory evidence regarding their effects. Here, the authors argue that these contradictory findings may have occurred because researchers have often examined complex practice combinations and have failed to investigate a broad variety of firm-level outcomes. Thus, past research may obscure important differential effects of specific practices on specific firm-level outcomes. Extending this research, the authors develop hypotheses about the effects of practices that (a) enable information sharing, (b) set boundaries, and (c) enable teams on 3 different firm-level outcomes: financial performance, customer service, and quality. Relationships are tested in a sample of observations from over 200 Fortune 1000 firms. Results indicate that information-sharing practices were positively related to financial performance 1 year following implementation of the practices, boundary-setting practices were positively related to firm-level customer service, and team-enabling practices were related to firm-level quality. No single set of practices predicted all 3 firm-level outcomes, indicating practice-specific effects. These findings help resolve the theoretical tension in the literature regarding the effects of organizational practices and offer guidance as to how to best target practices to increase specific work-related outcomes. Implications for theory, research, and practice are discussed. (c) 2007 APA

Illustrations from the Wellcome Library William Winstanley's pestilential poesies in "The Christians refuge: or heavenly antidotes against the plague in this time of generall contagion to which is added the charitable physician (1665)".

PubMed

Miller, Kathleen

2011-04-01

During the Great Plague of London (1665), William Winstanley veered from his better known roles as arbiter of success and failure in his works of biography or as a comic author under the pseudonym Poor Robin, and instead engaged with his reading audience as a plague writer in the rare book The Christians Refuge: Or Heavenly Antidotes Against the Plague in this Time of Generall Contagion to Which is Added the Charitable Physician (1665). From its extensive paratexts, including a table of mortality statistics and woodcut of king death, to its temporal and providential interpretation of the disease between the covers of a single text, The Christians Refuge is a compendium of contemporary understanding of plague. This article addresses The Christians Refuge as an expression of London's print marketplace in a moment of transformation precipitated by the epidemic. The author considers the paratextual elements in The Christians Refuge that engage with the presiding norms in plague writing and publishing in 1665 and also explores how Winstanley's authorship is expressed in the work. Winstanley has long been seen as a biographer or as a humour writer; attributing The Christians Refuge extends and challenges previous perceptions of his work.

Loss of phototaxis and degeneration of an eyespot in long-term algal cultures: evidence from ultrastructure and behaviour in the dinoflagellate Kryptoperidinium foliaceum.

PubMed

Moldrup, Morten; Moestrup, Øjvind; Hansen, Per Juel

2013-01-01

Phototaxis provides phytoplankton with the means to orient themselves in a light gradient. This is accomplished using an eyespot and associated organelles. For the dinoflagellate Kryptoperidinium foliaceum, which has been described as having one of the most elaborate eyespot complexes known, positive phototaxis has hitherto not been reported. In this study, we show that a newly isolated strain of K. foliaceum is indeed capable of positive phototaxis with a mean vector (± 95% confidence interval) of 352°± 2.2, where 0/360° indicates the position of the light source. A study of three strains (UTEX 1688, CCMP 1326, and MBL07) of K. foliaceum showed that the eyespot in two of these strains has degenerated following decades in culture. Thus, previous studies have failed to report positive phototaxis due to loss of directionality caused by the degenerated eyespot. The results are discussed in a broader context and we conclude that studies on algal morphology and physiology may result in erroneous conclusions if based on algal cultures maintained under laboratory conditions for extended periods. © 2013 The Author(s) Journal of Eukaryotic Microbiology © 2013 International Society of Protistologists.

The Likelihood of Injury Among Bias Crimes: An Analysis of General and Specific Bias Types.

PubMed

Pezzella, Frank S; Fetzer, Matthew D

2015-06-18

In 2009, President Barack Obama signed the Mathew Sheppard and James Byrd Jr. Hate Crimes Protection act and thereby extended the list of previously protected classes of victims from actual or perceived race, color, religion, national origin, disability and sex orientation to gender and gender identity. Over 45 states, the District of Columbia and the federal government now include hate crime statutes that increase penalties when offenders perpetrate hate crimes against protected classes of victims. Penalty enhancement statutes sanction unlawful bias conduct arguably because they result in more severe injuries relative to non-bias conduct. We contend that physical injuries vary by bias type and are not equally injurious. Data on bias crimes was analyzed from the National Incident Based Reporting System. Descriptive patterns of bias crimes were identified by offense type, bias motivation and major and minor injuries. Using Multivariate analyses, we found an escalating trend of violence against racial minorities. Moreover, relative to non-bias crimes, only anti-White and anti-lesbian bias crimes experienced our two prong "animus" criteria of disproportionate prevalence and severity of injury. However, when compared to anti-White bias, anti-Black bias crimes were more prevalent and likely to suffer serious injuries. Implications for hate crime jurisprudence are discussed. © The Author(s) 2015.

Decisions reduce sensitivity to subsequent information.

PubMed

Bronfman, Zohar Z; Brezis, Noam; Moran, Rani; Tsetsos, Konstantinos; Donner, Tobias; Usher, Marius

2015-07-07

Behavioural studies over half a century indicate that making categorical choices alters beliefs about the state of the world. People seem biased to confirm previous choices, and to suppress contradicting information. These choice-dependent biases imply a fundamental bound of human rationality. However, it remains unclear whether these effects extend to lower level decisions, and only little is known about the computational mechanisms underlying them. Building on the framework of sequential-sampling models of decision-making, we developed novel psychophysical protocols that enable us to dissect quantitatively how choices affect the way decision-makers accumulate additional noisy evidence. We find robust choice-induced biases in the accumulation of abstract numerical (experiment 1) and low-level perceptual (experiment 2) evidence. These biases deteriorate estimations of the mean value of the numerical sequence (experiment 1) and reduce the likelihood to revise decisions (experiment 2). Computational modelling reveals that choices trigger a reduction of sensitivity to subsequent evidence via multiplicative gain modulation, rather than shifting the decision variable towards the chosen alternative in an additive fashion. Our results thus show that categorical choices alter the evidence accumulation mechanism itself, rather than just its outcome, rendering the decision-maker less sensitive to new information. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

New configuration factors for curved surfaces

NASA Astrophysics Data System (ADS)

Cabeza-Lainez, Jose M.; Pulido-Arcas, Jesus A.

2013-03-01

Curved surfaces have not been thoroughly considered in radiative transfer analysis mainly due to the difficulties arisen in the integration process and perhaps because of the lack of spatial vision of the researchers. It is a fact, especially for architectural lighting, that when concave geometries appear inside a curved space, they are mostly avoided. In this way, a vast repertoire of significant forms is neglected and energy waste is evident. Starting from the properties of volumes enclosed by the minimum number of surfaces, the authors formulate, with little calculus, new simple laws, which enable them to discover a set of configuration factors for caps and various segments of the sphere. The procedure is subsequently extended to previously unimagined surfaces as the paraboloid, the ellipsoid or the cone. Appropriate combination of the said forms with right truncated cones produces several complex volumes, often used in architectural and engineering creations and whose radiative performance could not be accurately predicted for decades. To complete the research, a new method for determining interreflections in curved volumes is also presented. Radiative transfer simulation benefits from these findings, as the simplicity of the results has led the authors to create innovative software more efficient for design and evaluation and applicable to emerging fields like LED lighting.

Estimating and testing interactions when explanatory variables are subject to non-classical measurement error.

PubMed

Murad, Havi; Kipnis, Victor; Freedman, Laurence S

2016-10-01

Assessing interactions in linear regression models when covariates have measurement error (ME) is complex.We previously described regression calibration (RC) methods that yield consistent estimators and standard errors for interaction coefficients of normally distributed covariates having classical ME. Here we extend normal based RC (NBRC) and linear RC (LRC) methods to a non-classical ME model, and describe more efficient versions that combine estimates from the main study and internal sub-study. We apply these methods to data from the Observing Protein and Energy Nutrition (OPEN) study. Using simulations we show that (i) for normally distributed covariates efficient NBRC and LRC were nearly unbiased and performed well with sub-study size ≥200; (ii) efficient NBRC had lower MSE than efficient LRC; (iii) the naïve test for a single interaction had type I error probability close to the nominal significance level, whereas efficient NBRC and LRC were slightly anti-conservative but more powerful; (iv) for markedly non-normal covariates, efficient LRC yielded less biased estimators with smaller variance than efficient NBRC. Our simulations suggest that it is preferable to use: (i) efficient NBRC for estimating and testing interaction effects of normally distributed covariates and (ii) efficient LRC for estimating and testing interactions for markedly non-normal covariates. © The Author(s) 2013.

Optimal electromagnetic energy transmission and real-time dissipation in extended media.

PubMed

Glasgow, S; Ware, M

2014-02-24

Pulse reshaping effects that give rise to fast and slow light phenomena are inextricably linked to the dynamics of energy exchange between the pulse and the propagation medium. Energy that is dissipated from the pulse can no longer participate in this exchange process, but previous methods of calculating real-time dissipation are not valid for extended propagation media. We present a method for calculating real-time dissipation that is valid for electromagnetic pulse propagation in extended media. This method allows one to divide the energy stored in an extended medium into the portion that can be later transmitted out of the medium, and that portion which must be lost to either dissipation or reflection.

3D-SIFT-Flow for atlas-based CT liver image segmentation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, Yan, E-mail: xuyan04@gmail.com; Xu, Chenchao, E-mail: chenchaoxu33@gmail.com; Kuang, Xiao, E-mail: kuangxiao.ace@gmail.com

Purpose: In this paper, the authors proposed a new 3D registration algorithm, 3D-scale invariant feature transform (SIFT)-Flow, for multiatlas-based liver segmentation in computed tomography (CT) images. Methods: In the registration work, the authors developed a new registration method that takes advantage of dense correspondence using the informative and robust SIFT feature. The authors computed the dense SIFT features for the source image and the target image and designed an objective function to obtain the correspondence between these two images. Labeling of the source image was then mapped to the target image according to the former correspondence, resulting in accurate segmentation.more » In the fusion work, the 2D-based nonparametric label transfer method was extended to 3D for fusing the registered 3D atlases. Results: Compared with existing registration algorithms, 3D-SIFT-Flow has its particular advantage in matching anatomical structures (such as the liver) that observe large variation/deformation. The authors observed consistent improvement over widely adopted state-of-the-art registration methods such as ELASTIX, ANTS, and multiatlas fusion methods such as joint label fusion. Experimental results of liver segmentation on the MICCAI 2007 Grand Challenge are encouraging, e.g., Dice overlap ratio 96.27% ± 0.96% by our method compared with the previous state-of-the-art result of 94.90% ± 2.86%. Conclusions: Experimental results show that 3D-SIFT-Flow is robust for segmenting the liver from CT images, which has large tissue deformation and blurry boundary, and 3D label transfer is effective and efficient for improving the registration accuracy.« less

Effect of magnetization boundary condition on cavity magnon polariton of YIG thin film.

PubMed

Jiang, H H; Xiao, Y; Hu, C M; Guo, H; Xia, K

2018-06-22

Motivated by recent studies of cavity magnon polariton (CMP), we extended a previous theoretical work to generalize microwave transmission calculation with various magnetization boundary condition of YIG thin film embedded in cavity. It is found that numerical implementation given in this paper can be easily applied to other magnetization boundary condition and extended to magnetic multilayers. Numerical results show that ferromagnetic resonance mode of microwave transmission spectrum, which is absent in previous calculation, can be recovered by altering the pinning condition of surface spins. The demonstrated reliability of our theory opens attractive perspectives for studying CMP of thin film with complicated surface magnetization distribution and magnetic multilayers.

Effect of magnetization boundary condition on cavity magnon polariton of YIG thin film

NASA Astrophysics Data System (ADS)

Jiang, H. H.; Xiao, Y.; Hu, C. M.; Guo, H.; Xia, K.

2018-06-01

Motivated by recent studies of cavity magnon polariton (CMP), we extended a previous theoretical work to generalize microwave transmission calculation with various magnetization boundary condition of YIG thin film embedded in cavity. It is found that numerical implementation given in this paper can be easily applied to other magnetization boundary condition and extended to magnetic multilayers. Numerical results show that ferromagnetic resonance mode of microwave transmission spectrum, which is absent in previous calculation, can be recovered by altering the pinning condition of surface spins. The demonstrated reliability of our theory opens attractive perspectives for studying CMP of thin film with complicated surface magnetization distribution and magnetic multilayers.

Extended kin and children's behavioral functioning: Family structure and parental immigrant status.

PubMed

Kang, Jeehye; Cohen, Philip N

2017-08-01

Using the Los Angeles Family and Neighborhood Survey (L.A. FANS), this paper examines the association between the presence of co-resident extended kin and children's internalizing and externalizing behaviors. The paper demonstrates the differential role of extended kin by family structure, as well as across parental immigrant status - specifically, nativity and documentation status. Children in the sample were found to be disadvantaged in extended family households, especially with regard to internalizing behaviors. This disadvantageous association was found mostly among married-parent extended family households, whereas there was no association between the presence of extended kin and behavior problems in children from single-parent families. This pattern emerged more clearly among children of documented immigrants, compared to those with native-born parents and those whose parents were unauthorized immigrants. These findings suggest a need to modify previous theories on extended family living arrangements; they also provide policy implications for immigrant families. Copyright © 2017 Elsevier Ltd. All rights reserved.

Automated Generation of Fault Management Artifacts from a Simple System Model

NASA Technical Reports Server (NTRS)

Kennedy, Andrew K.; Day, John C.

2013-01-01

Our understanding of off-nominal behavior - failure modes and fault propagation - in complex systems is often based purely on engineering intuition; specific cases are assessed in an ad hoc fashion as a (fallible) fault management engineer sees fit. This work is an attempt to provide a more rigorous approach to this understanding and assessment by automating the creation of a fault management artifact, the Failure Modes and Effects Analysis (FMEA) through querying a representation of the system in a SysML model. This work builds off the previous development of an off-nominal behavior model for the upcoming Soil Moisture Active-Passive (SMAP) mission at the Jet Propulsion Laboratory. We further developed the previous system model to more fully incorporate the ideas of State Analysis, and it was restructured in an organizational hierarchy that models the system as layers of control systems while also incorporating the concept of "design authority". We present software that was developed to traverse the elements and relationships in this model to automatically construct an FMEA spreadsheet. We further discuss extending this model to automatically generate other typical fault management artifacts, such as Fault Trees, to efficiently portray system behavior, and depend less on the intuition of fault management engineers to ensure complete examination of off-nominal behavior.

Hierarchical neural network model of the visual system determining figure/ground relation

NASA Astrophysics Data System (ADS)

Kikuchi, Masayuki

2017-07-01

One of the most important functions of the visual perception in the brain is figure/ground interpretation from input images. Figural region in 2D image corresponding to object in 3D space are distinguished from background region extended behind the object. Previously the author proposed a neural network model of figure/ground separation constructed on the standpoint that local geometric features such as curvatures and outer angles at corners are extracted and propagated along input contour in a single layer network (Kikuchi & Akashi, 2001). However, such a processing principle has the defect that signal propagation requires manyiterations despite the fact that actual visual system determines figure/ground relation within the short period (Zhou et al., 2000). In order to attain speed-up for determining figure/ground, this study incorporates hierarchical architecture into the previous model. This study confirmed the effect of the hierarchization as for the computation time by simulation. As the number of layers increased, the required computation time reduced. However, such speed-up effect was saturatedas the layers increased to some extent. This study attempted to explain this saturation effect by the notion of average distance between vertices in the area of complex network, and succeeded to mimic the saturation effect by computer simulation.

Quitting-Unmotivated and Quitting-Motivated Cigarette Smokers Exhibit Different Patterns of Cue-Elicited Brain Activation When Anticipating an Opportunity to Smoke

PubMed Central

Wilson, Stephen J.; Sayette, Michael A.; Fiez, Julie A.

2013-01-01

The authors examined the effects of smoking expectancy on cue-reactivity among those motivated and those unmotivated to quit smoking using functional magnetic resonance imaging. Cue-elicited activation was observed in the rostral prefrontal cortex (PFC) in smokers who expected to smoke within seconds, but not in those who expected to have to wait hours before having the chance to smoke, regardless of quitting motivation. For quitting-unmotivated smokers expecting to smoke, rostral PFC activation was strongly positively correlated with the activation of several areas previously linked to cue-reactivity, including the medial orbitofrontal cortex (OFC) and rostral anterior cingulate cortex (ACC). In contrast, there was a non-significant negative relationship between activation of the rostral PFC and activation of the medial OFC/rostral ACC in quitting-motivated smokers expecting to smoke. Results extend previous work examining the effects of smoking expectancy and highlight the utility of examining interregional covariation during cue exposure. Findings also suggest that investigators may need to pay close attention to the motivational contexts associated with their experiments when studying cue-reactivity, as these contexts can modulate not only responses to drug cues, but perhaps also the functional implications of observed activity. PMID:21859165

Extension of expiration date for temporary pilot program setting the time and place for a hearing before an administrative law judge. Final rule.

PubMed

2014-07-18

We are extending for one year our pilot program that authorizes the agency to set the time and place for a hearing before an administrative law judge (ALJ). Extending the pilot program continues our commitment to improve the efficiency of our hearing process and provide accurate, high-quality decisions for claimants. The current pilot program will expire on August 9, 2014. In this final rule, we are extending the expiration date to August 10, 2015. We are making no other substantive changes.

Moving Beyond Conventional Wisdom: Advancements in Cross-Cultural Theories of Leadership, Conflict, and Teams.

PubMed

Gibson, Cristina B; McDaniel, Dana M

2010-07-01

In this article, we discuss the importance of a cross-cultural approach to organizational behavior. To do so, we illustrate how cross-cultural research in the past two decades has enabled us to reconceptualize constructs, revise models, and extend boundary conditions in traditional organizational behavior theories. We focus on three domains-teams, leadership, and conflict-and review cross-cultural empirical evidence that has extended several theories in each of these domains. We support the claim that even well-established organizational behavior theories vary in the extent to which they may be applied unilaterally across cultures, thus identifying the critical need to advance these theories via a cross-cultural research agenda. © The Author(s) 2010.

Interactome of the hepatitis C virus: Literature mining with ANDSystem.

PubMed

Saik, Olga V; Ivanisenko, Timofey V; Demenkov, Pavel S; Ivanisenko, Vladimir A

2016-06-15

A study of the molecular genetics mechanisms of host-pathogen interactions is of paramount importance in developing drugs against viral diseases. Currently, the literature contains a huge amount of information that describes interactions between HCV and human proteins. In addition, there are many factual databases that contain experimentally verified data on HCV-host interactions. The sources of such data are the original data along with the data manually extracted from the literature. However, the manual analysis of scientific publications is time consuming and, because of this, databases created with such an approach often do not have complete information. One of the most promising methods to provide actualisation and completeness of information is text mining. Here, with the use of a previously developed method by the authors using ANDSystem, an automated extraction of information on the interactions between HCV and human proteins was conducted. As a data source for the text mining approach, PubMed abstracts and full text articles were used. Additionally, external factual databases were analyzed. On the basis of this analysis, a special version of ANDSystem, extended with the HCV interactome, was created. The HCV interactome contains information about the interactions between 969 human and 11 HCV proteins. Among the 969 proteins, 153 'new' proteins were found not previously referred to in any external databases of protein-protein interactions for HCV-host interactions. Thus, the extended ANDSystem possesses a more comprehensive detailing of HCV-host interactions versus other existing databases. It was interesting that HCV proteins more preferably interact with human proteins that were already involved in a large number of protein-protein interactions as well as those associated with many diseases. Among human proteins of the HCV interactome, there were a large number of proteins regulated by microRNAs. It turned out that the results obtained for protein-protein interactions and microRNA-regulation did not depend on how well the proteins were studied, while protein-disease interactions appeared to be dependent on the level of study. In particular, the mean number of diseases linked to well-studied proteins (proteins were considered well-studied if they were mentioned in 50 or more PubMed publications) from the HCV interactome was 20.8, significantly exceeding the mean number of associations with diseases (10.1) for the total set of well-studied human proteins present in ANDSystem. For proteins not highly poorly-studied investigated, proteins from the HCV interactome (each protein was referred to in less than 50 publications) distribution of the number of diseases associated with them had no statistically significant differences from the distribution of the number of diseases associated with poorly-studied proteins based on the total set of human proteins stored in ANDSystem. With this, the average number of associations with diseases for the HCV interactome and the total set of human proteins were 0.3 and 0.2, respectively. Thus, ANDSystem, extended with the HCV interactome, can be helpful in a wide range of issues related to analyzing HCV-host interactions in the search for anti-HCV drug targets. The demo version of the extended ANDSystem covered here containing only interactions between human proteins, genes, metabolites, diseases, miRNAs and molecular-genetic pathways, as well as interactions between human proteins/genes and HCV proteins, is freely available at the following web address: http://www-bionet.sscc.ru/psd/andhcv/. Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

High body mass index is associated with impaired cognitive control.

PubMed

Sellaro, Roberta; Colzato, Lorenza S

2017-06-01

The prevalence of weight problems is increasing worldwide. There is growing evidence that high body mass index (BMI) is associated with frontal lobe dysfunction and cognitive deficits concerning mental flexibility and inhibitory control efficiency. The present study aims at replicating and extending these observations. We compared cognitive control performance of normal weight (BMI < 25) and overweight (BMI ≥ 25) university students on a task tapping either inhibitory control (Experiment 1) or interference control (Experiment 2). Experiment 1 replicated previous findings that found less efficient inhibitory control in overweight individuals. Experiment 2 complemented these findings by showing that cognitive control impairments associated with high BMI also extend to the ability to resolve stimulus-induced response conflict and to engage in conflict-driven control adaptation. The present results are consistent with and extend previous literature showing that high BMI in young, otherwise healthy individuals is associated with less efficient cognitive control functioning. Copyright © 2017 Elsevier Ltd. All rights reserved.

Generalized Detectability for Discrete Event Systems

PubMed Central

Shu, Shaolong; Lin, Feng

2011-01-01

In our previous work, we investigated detectability of discrete event systems, which is defined as the ability to determine the current and subsequent states of a system based on observation. For different applications, we defined four types of detectabilities: (weak) detectability, strong detectability, (weak) periodic detectability, and strong periodic detectability. In this paper, we extend our results in three aspects. (1) We extend detectability from deterministic systems to nondeterministic systems. Such a generalization is necessary because there are many systems that need to be modeled as nondeterministic discrete event systems. (2) We develop polynomial algorithms to check strong detectability. The previous algorithms are based on observer whose construction is of exponential complexity, while the new algorithms are based on a new automaton called detector. (3) We extend detectability to D-detectability. While detectability requires determining the exact state of a system, D-detectability relaxes this requirement by asking only to distinguish certain pairs of states. With these extensions, the theory on detectability of discrete event systems becomes more applicable in solving many practical problems. PMID:21691432

Extending the Stay: Using Community-Based Research and Service Learning to Enhance Short-Term Study Abroad

ERIC Educational Resources Information Center

Lewis, Tammy L.; Niesenbaum, Richard A.

2005-01-01

Short-term study abroad (STSA) is an important alternative for students not likely to participate in semester-long or yearlong international study abroad programs. The authors present an assessment of their short-term study abroad program, Environmental and Cultural Conservation in Latin America. The authors show that STSA programs appeal to…

Students and School Adults: Partners in Keeping Schools Safe

ERIC Educational Resources Information Center

Gastic, Billie

2010-01-01

In this article, the author discusses the important roles that students, school staff and teachers play in keeping the school safe particularly from weapons. The author believes that one way that they do this is by working together to reduce the problem of weapons in school. The role of school staff and teachers extends beyond prevention and…

Enhancing Student Motivation: A Longitudinal Intervention Study Based on Future Time Perspective Theory

ERIC Educational Resources Information Center

Schuitema, Jaap; Peetsma, Thea; van der Veen, Ineke

2014-01-01

The authors investigated the effects of an intervention developed to enhance student motivation in the first years of secondary education. The intervention, based on future time perspective (FTP) theory, has been found to be effective in prevocational secondary education (T. T. D. Peetsma & I. Van der Veen, 2008, 2009). The authors extend the…

75 FR 51124 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

...-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Relating to Amendments to FINRA Rule 2360 To Extend the Time To Submit a Contrary Exercise Advice and the Time for a Final Exercise Decision in the Event of a Modified Close of...

When the Tenets of Composition Go Public: A Study of Writing in Wikipedia

ERIC Educational Resources Information Center

Purdy, James P.

2009-01-01

Based on a study of observable changes author-users made to three Wikipedia articles, this article contends that Wikipedia supports notions of revision, collaboration, and authority that writing studies purports to value, while also extending our understanding of the production of knowledge in public spaces. It argues that Wikipedia asks us to…

Peer-Based Control in Self-Managing Teams: Linking Rational and Normative Influence with Individual and Group Performance

ERIC Educational Resources Information Center

Stewart, Greg L.; Courtright, Stephen H.; Barrick, Murray R.

2012-01-01

The authors use a multilevel framework to introduce peer-based control as a motivational state that emerges in self-managing teams. The authors specifically describe how "peer-based rational control", which is defined as team members perceiving the distribution of economic rewards as dependent on input from teammates, extends and…

Extension of the Rejection Sensitivity Construct to the Interpersonal Functioning of Gay Men

ERIC Educational Resources Information Center

Pachankis, John E.; Goldfried, Marvin R.; Ramrattan, Melissa E.

2008-01-01

On the basis of recent evidence suggesting that gay men are particularly likely to fear interpersonal rejection, the authors set out to extend the "rejection sensitivity" construct to the mental health concerns of gay men. After establishing a reliable and valid measure of the gay-related rejection sensitivity construct, the authors use this to…

Technopotters and Webs of Clay: Digital Possibilities for Teaching Ceramics

ERIC Educational Resources Information Center

Weida, Courtney Lee

2007-01-01

In this article, the author examines ways in which the Internet is changing the way ceramicists teach, learn, and work. She addresses the curricular issue of how Web resources may supplement ceramic art history and extend student-centered learning. The author also explores the nature of the interplay between computer technology and clay. (Contains…

Pragmatism and Progressivism in the Educational Thought and Practices of Booker T. Washington

ERIC Educational Resources Information Center

Chennault, Ronald E.

2013-01-01

The author of this article asserts that African-American author and educator Booker T. Washington's work situates him within the educational traditions of pragmatism and progressivism. The article uncovers some of Washington's hidden complexity by drawing upon and extending arguments for labeling him both an educational pragmatist and…

Treatment for Acquired Apraxia of Speech: Examination of Treatment Intensity and Practice Schedule

ERIC Educational Resources Information Center

Wambaugh, Julie L.; Nessler, Christina; Cameron, Rosalea; Mauszycki, Shannon C.

2013-01-01

Purpose: The authors designed this investigation to extend the development of a treatment for acquired apraxia of speech (AOS)--sound production treatment (SPT)--by examining the effects of 2 treatment intensities and 2 schedules of practice. Method: The authors used a multiple baseline design across participants and behaviors with 4 speakers with…

Corrupting Conversations with the Marquis de Sade: On Education, Gender, and Sexuality

ERIC Educational Resources Information Center

Greteman, Adam J.

2016-01-01

In this essay, the author joins a conversation started by Martin ("Reclaiming the conversation: the ideal of the educated woman." Yale University Press, New Haven, 1985) regarding gender and education seeking to extend the conversation to address sexuality. To do so, the author brings a reading of the Marquis de Sade to challenge the…

77 FR 56909 - Notice of Comment Period Extension for the Revised Draft Environmental Impact Report/Supplemental...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-14

... for the California High-Speed Train Project Fresno to Bakersfield Section AGENCY: Federal Railroad... High-Speed Train (HST) Project (Project) issued on June 20, 2012 has been extended and shall now end on October 19, 2012. FRA and the Project sponsor, the California High Speed Rail Authority (Authority), made...

Extending the Dialogue about Science and Humanities in Counseling: A Reply to Hansen

ERIC Educational Resources Information Center

Martin, Clayton V.; Guterman, Jeffrey T.; Kopp, David M.

2012-01-01

This is a reply to Hansen's (2012b) rejoinder to the authors (Guterman, Martin, & Kopp, 2012), which is a response to Hansen's (2012a) keystone article about the relationship between humanities and science in counseling. In this reply, the authors provide remaining clarifications, points of disagreement, and suggestions for future directions in…

Retroperitoneal liposarcoma extending into the thigh.

PubMed

Salemis, Nikolaos S; Nisotakis, Konstantinos; Patouras, Paraskevas; Karagkiouzis, Grigorios; Gourgiotis, Stavros

2011-05-01

The authors describe a case of a giant retroperitoneal liposarcoma that extended into the thigh along the course of the iliopsoas muscle. The tumor was successfully excised en bloc through an abdominal and a proximal thigh incision. Histopathologic examination revealed a well-differentiated, lipoma-like liposarcoma with clear surgical margins. The patient remains well without any evidence of tumor recurrence 18 months after surgery. Copyright © 2011 Elsevier Inc. All rights reserved.

Is It Choice or Is It Interest? The Effect of Choice on the Cognitive and Affective Engagement of Elementary Students Performing a Reading Task

ERIC Educational Resources Information Center

Scott, Jerilyn Carter

2012-01-01

The author replicated and extended a study by Flowerday, Schraw, & Stevens (2004) that examined the effects of choice, topic interest, and situational interest on reading engagement, attitude, and learning in college-age students. The study was replicated using fourth and fifth graders as subjects. The study was extended to examine the effects of…

Ten-Ecosystem Study (TES) site 9, Washington County, Missouri

NASA Technical Reports Server (NTRS)

Echert, W. H. (Principal Investigator)

1979-01-01

The author has identified the following significant results. Sufficient spectral separability exists among softwood, hardwood, grassland, and water to develop a level 2 classification and inventory. Using the tested automatic data processing technology, softwood and grassland signatures can be extended across the county with acceptable accuracy; with more dense sampling, the hardwood signature probably could also be extended. Fall was found to be the best season for mapping this ecosystem.

Contribution to viscosity from the structural relaxation via the atomic scale Green-Kubo stress correlation function.

PubMed

Levashov, V A

2017-11-14

We studied the connection between the structural relaxation and viscosity for a binary model of repulsive particles in the supercooled liquid regime. The used approach is based on the decomposition of the macroscopic Green-Kubo stress correlation function into the correlation functions between the atomic level stresses. Previously we used the approach to study an iron-like single component system of particles. The role of vibrational motion has been addressed through the demonstration of the relationship between viscosity and the shear waves propagating over large distances. In our previous considerations, however, we did not discuss the role of the structural relaxation. Here we suggest that the contribution to viscosity from the structural relaxation can be taken into account through the consideration of the contribution from the atomic stress auto-correlation term only. This conclusion, however, does not mean that only the auto-correlation term represents the contribution to viscosity from the structural relaxation. Previously the role of the structural relaxation for viscosity has been addressed through the considerations of the transitions between inherent structures and within the mode-coupling theory by other authors. In the present work, we study the structural relaxation through the considerations of the parent liquid and the atomic level stress correlations in it. The comparison with the results obtained on the inherent structures also is made. Our current results suggest, as our previous observations, that in the supercooled liquid regime, the vibrational contribution to viscosity extends over the times that are much larger than the Einstein's vibrational period and much larger than the times that it takes for the shear waves to propagate over the model systems. Besides addressing the atomic level shear stress correlations, we also studied correlations between the atomic level pressure elements.

Contribution to viscosity from the structural relaxation via the atomic scale Green-Kubo stress correlation function

NASA Astrophysics Data System (ADS)

Levashov, V. A.

2017-11-01

We studied the connection between the structural relaxation and viscosity for a binary model of repulsive particles in the supercooled liquid regime. The used approach is based on the decomposition of the macroscopic Green-Kubo stress correlation function into the correlation functions between the atomic level stresses. Previously we used the approach to study an iron-like single component system of particles. The role of vibrational motion has been addressed through the demonstration of the relationship between viscosity and the shear waves propagating over large distances. In our previous considerations, however, we did not discuss the role of the structural relaxation. Here we suggest that the contribution to viscosity from the structural relaxation can be taken into account through the consideration of the contribution from the atomic stress auto-correlation term only. This conclusion, however, does not mean that only the auto-correlation term represents the contribution to viscosity from the structural relaxation. Previously the role of the structural relaxation for viscosity has been addressed through the considerations of the transitions between inherent structures and within the mode-coupling theory by other authors. In the present work, we study the structural relaxation through the considerations of the parent liquid and the atomic level stress correlations in it. The comparison with the results obtained on the inherent structures also is made. Our current results suggest, as our previous observations, that in the supercooled liquid regime, the vibrational contribution to viscosity extends over the times that are much larger than the Einstein's vibrational period and much larger than the times that it takes for the shear waves to propagate over the model systems. Besides addressing the atomic level shear stress correlations, we also studied correlations between the atomic level pressure elements.

Examining the "Neglected Side of the Work-Family Interface": Antecedents of Positive and Negative Family-to-Work Spillover

ERIC Educational Resources Information Center

Stevens, Daphne Pedersen; Minnotte, Krista Lynn; Mannon, Susan E.; Kiger, Gary

2007-01-01

This study extends previous research by Dilworth by examining antecedents of both positive and negative family-to-work spillover--a long-neglected area of research. It also uses an extended definition of domestic labor that includes emotion work and status enhancement. Using data from a random sample of dual-earner couples, the study found gender…

Implementing the Extended School Day Policy in Florida's 300 Lowest Performing Elementary Schools. REL 2017-253

ERIC Educational Resources Information Center

Folsom, Jessica Sidler; Osborne-Lampkin, La'Tara; Cooley, Stephan; Smith, Kevin

2017-01-01

Since the 2012/13 school year Florida law has required the 100 lowest performing elementary schools in reading to extend the school day by one hour to provide supplemental reading instruction. In 2014 the law was broadened to include the 300 elementary schools with the lowest reading performance. A previous study of the state's first two cohorts…

Klebsiella pneumoniae Strains Producing Extended-Spectrum β-Lactamases in Spain: Microbiological and Clinical Features▿

PubMed Central

de Alegría, C. Ruiz; Rodríguez-Baño, J.; Cano, M. E.; Hernández-Bello, J. R.; Calvo, J.; Román, E.; Díaz, M. A.; Pascual, A.; Martínez-Martínez, L.

2011-01-01

Extended-spectrum β-lactamases (ESBL) of the CTX-M, SHV, and TEM families were recognized in 76 (67%), 31 (27%), and 6 (5%) isolates, respectively, among 162 ESBL-producing Klebsiella pneumoniae (ESBL-Kp) strains obtained in a multicenter study in Spain. Predisposing factors for ESBL-Kp acquisition included invasive procedures, mechanical ventilation, and previous antimicrobial use. PMID:21191059

Disformally self-tuning gravity

NASA Astrophysics Data System (ADS)

Emond, William T.; Saffin, Paul M.

2016-03-01

We extend a previous self-tuning analysis of the most general scalar-tensor theory of gravity in four dimensions with second order field equations by considering a generalized coupling to the matter sector. Through allowing a disformal coupling to matter we are able to extend the Fab Four model and construct a new class of theories that are able to tune away the cosmological constant on Friedmann-Lemaitre-Robertson-Walker backgrounds.

A Confirmatory Study of Rating Scale Category Effectiveness for the Coaching Efficacy Scale

ERIC Educational Resources Information Center

Myers, Nicholas D.; Feltz, Deborah L.; Wolfe, Edward W.

2008-01-01

This study extended validity evidence for measures of coaching efficacy derived from the Coaching Efficacy Scale (CES) by testing the rating scale categorizations suggested in previous research. Previous research provided evidence for the effectiveness of a four-category (4-CAT) structure for high school and collegiate sports coaches; it also…

Teenagers' Perceptions of Communication and "Good Communication" with Peers, Young Adults, and Older Adults

ERIC Educational Resources Information Center

Williams, Angie; Garrett, Peter

2012-01-01

Taking an intergroup communication perspective, this study extends previous research into intergenerational communication. Firstly, we widen the respondent base, insofar as much previous research has tended to use college/university student respondents. Here, we asked young teenagers aged 12-16 years about their communication experiences with…

A deconstruction of the I-M-L commitment segmentation of forest recreationists

Treesearch

James D. Absher; Gerard T. Kyle

2007-01-01

Previous work has established the general utility of segmenting forest recreationists according to their commitment profiles into Indifferents, Moderates, and Loyalists (IML) groups. Observed differences between these segments suggest that place identity and affect are more central to management than previously thought. This study extends this finding through the use...

Reconceptualizing Reactivity of Think-Alouds and Eye Tracking: Absence of Evidence Is Not Evidence of Absence

ERIC Educational Resources Information Center

Godfroid, Aline; Spino, Le Anne

2015-01-01

This study extends previous reactivity research on the cognitive effects of think-alouds to include eye-tracking methodology. Unlike previous studies, we supplemented traditional superiority tests with equivalence tests, because only the latter are conceptually appropriate for demonstrating nonreactivity. Advanced learners of English read short…

Educational Assessment Profile of Teachers in the Sultanate of Oman

ERIC Educational Resources Information Center

Alkharusi, Hussain; Aldhafri, Said; Alnabhani, Hilal; Alkalbani, Muna

2014-01-01

This study builds on a previous pilot study conducted by Alkharusi, Aldhafri, Alnabhani, and Alkalbani (2012) to explore educational assessment attitudes, competence, knowledge, and practices of in-service teachers in the Sultanate of Oman. The present study extends the previous pilot study by surveying a larger sample of in-serivce teachers…

Amnesia of Inhibitory Avoidance by Scopolamine Is Overcome by Previous Openfield Exposure

ERIC Educational Resources Information Center

Colettis, Natalia C.; Snitcofsky, Marina; Kornisiuk, Edgar E.; Gonzalez, Emilio N.; Quillfeldt, Jorge A.; Jerusalinsky, Diana A.

2014-01-01

The muscarinic cholinergic receptor (MAChR) blockade with scopolamine either extended or restricted to the hippocampus, before or after training in inhibitory avoidance (IA) caused anterograde or retrograde amnesia, respectively, in the rat, because there was no long-term memory (LTM) expression. Adult Wistar rats previously exposed to one or two…

Family Stress, Parenting Styles, and Behavioral Adjustment in Preschool-Age Adopted Chinese Girls

ERIC Educational Resources Information Center

Tan, Tony Xing; Camras, Linda A.; Deng, Huihua; Zhang, Minghao; Lu, Zuhong

2012-01-01

This study seeks to extend previous research on family stress, parenting, and child adjustment to families with adopted Chinese children. In doing so, we also seek to strengthen inferences regarding the experiential underpinnings of previously obtained relationships among these variables by determining if they also occur in families where parents…

Strengthening practical wisdom: mental health workers' learning and development.

PubMed

Eriksen, Kristin Ådnøy; Dahl, Hellen; Karlsson, Bengt; Arman, Maria

2014-09-01

Practical wisdom, understood as knowing how to be or act in any present situation with clients, is believed to be an essential part of the knowledge needed to be a professional mental health worker. Exploring processes of adapting, extending knowledge and refining tacit knowledge grounded in mental health workers' experiences with being in practice may bring awareness of how mental health workers reflect, learn and practice professional 'artistry'. The aim of the article was to explore mental health workers' processes of development and learning as they appeared in focus groups intended to develop practical wisdom. The main research question was 'How might the processes of development and learning contribute to developing practical wisdom in the individual as well as in the practice culture?' The design was multi-stage focus groups, and the same participants met four times. A phenomenological hermeneutical method for researching lived experience guided the analysis. Eight experienced mental health workers representing four Norwegian municipalities participated. The research context was community-based mental health services. The study was reported to Norwegian Social Data Services, and procedures for informed consent were followed. Two examples of processes of re-evaluation of experience (Association, Integration, Validation, Appropriation and Outcomes and action) were explored. The health workers had developed knowledge in previous encounters with clients. In sharing practice experiences, this knowledge was expressed and developed, and also tested and validated against the aims of practice. Discussions led to adapted and extended knowledge, and as tacit knowledge was expressed it could be used actively. Learning to reflect, being ready to be provoked and learning to endure indecisiveness may be foundational in developing practical wisdom. Openness is demanding, and changing habits of mind is difficult. Reflection on, and confrontation with, set practices are essential to building practice cultures in line with the aims of mental health services. © The Author(s) 2014.

Comments on "extended zonal dislocations mediating ? ? twinning in titanium"

NASA Astrophysics Data System (ADS)

El Kadiri, Haitham; Barrett, Christopher D.

2013-09-01

In a recent paper, Li et al. (Philos. Mag. 92 (2012) p.1006) used results of atomistic simulations to advance a growth mechanism of ? ? twinning in titanium based on the concept of two elementary twinning dislocations which nucleate and glide in pairs but separately and sequentially on two neighbouring planes. This new Comment was stimulated after A. Serra, D.J. Bacon and R.C. Pond privately raised concerns on this growth model to one of the present authors, H. El Kadiri, who This was a co-author of the original paper (Philos. Mag. 92 (2012) p.1006). We repeated the simulations and obtained nearly the same simulations results as Li et al. However, after re-analysing these results, we have concluded that the extended extrinsic zonal dislocation mechanism claimed to be that for twin growth in titanium is in fact false, confirming the accuracy of the Comment by Serra et al that results of Li and co-authors were misinterpreted.

Studies Update Vinyl Chloride Hazards.

ERIC Educational Resources Information Center

Rawls, Rebecca

1980-01-01

Extensive study affirms that vinyl chloride is a potent animal carcinogen. Epidemiological studies show elevated rates of human cancers in association with extended contact with the compound. (Author/RE)

75 FR 21391 - Sunshine Act Meeting Notice

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-23

... TENNESSEE VALLEY AUTHORITY Sunshine Act Meeting Notice Agency Holding the Meeting: Tennessee Valley Authority. Federal Register Citation of Previous Announcement: 75 FR 19465 (April 14, 2010). Previously Announced Time and Date of Meeting: Immediately following 8:30 a.m. listening session, April 16...

Extended Le Chatelier's formula for carbon dioxide dilution effect on flammability limits.

PubMed

Kondo, Shigeo; Takizawa, Kenji; Takahashi, Akifumi; Tokuhashi, Kazuaki

2006-11-02

Carbon dioxide dilution effect on the flammability limits was measured for various flammable gases. The obtained values were analyzed using the extended Le Chatelier's formula developed in a previous study. As a result, it has been found that the flammability limits of methane, propane, propylene, methyl formate, and 1,1-difluoroethane are adequately explained by the extended Le Chatelier's formula using a common set of parameter values. Ethylene, dimethyl ether, and ammonia behave differently from these compounds. The present result is very consistent with what was obtained in the case of nitrogen dilution.

Generalized extended Lagrangian Born-Oppenheimer molecular dynamics

DOE PAGES

Niklasson, Anders M. N.; Cawkwell, Marc J.

2014-10-29

Extended Lagrangian Born-Oppenheimer molecular dynamics based on Kohn-Sham density functional theory is generalized in the limit of vanishing self-consistent field optimization prior to the force evaluations. The equations of motion are derived directly from the extended Lagrangian under the condition of an adiabatic separation between the nuclear and the electronic degrees of freedom. We show how this separation is automatically fulfilled and system independent. The generalized equations of motion require only one diagonalization per time step and are applicable to a broader range of materials with improved accuracy and stability compared to previous formulations.

IHC-TM connect-disconnect and efferent control V.

PubMed

Crane, H D

1982-07-01

Four previous papers in this series have explored how the idea of a set of disconnected inner hair cells (IHCs) that can "impact" the tectorial membrane (TM) is consistent with psychophysical data. This paper extends the model and explores the potential for mechanical interaction between the IHCs and outer hair cells (OHCs). In particular, it is speculated that the advantage of IHC-TM disconnect is extended dynamic range, and that movement of the movement of the OHCs and TM, under efferent control, constitutes a mechanical servo system for adjusting IHC-TM spacing along the cochlear partition to achieve this extended range.

Work and Family Characteristics as Predictors of Early Retirement in Married Men and Women

PubMed Central

Kubicek, Bettina; Korunka, Christian; Hoonakker, Peter; Raymo, James M.

2010-01-01

This study presents an integrative model of early retirement using data from the Wisconsin Longitudinal Study. The model extends prior work by incorporating work-family conflict to capture the interaction between the work and family domains and by assuming proximal and distal predictors of early retirement. More precisely, the model suggests that family and job demands and resources predict family-to-work and work-to-family conflict, respectively. All of these factors are presumed to have only indirect effects on retirement timing via the intervening effect of quality of life measures, that is, marital satisfaction, job satisfaction and health. The authors assume that these three factors constitute predictors of early retirement in addition to socioeconomic status and the availability of a pension plan and health insurance. The model was tested with structural equation modeling techniques, and the results were supportive. Therefore, the proposed model offers a general framework for the integration of previous research findings. PMID:21430790

Finding the critical cue: implementation intentions to change one's diet work best when tailored to personally relevant reasons for unhealthy eating.

PubMed

Adriaanse, Marieke A; de Ridder, Denise T D; de Wit, John B F

2009-01-01

Implementation intentions promote acting on one's good intentions. But does specifying where and when to act also suffice when goals involve complex change that requires not merely initiating a behavior but rather substituting a habit with a new response? In a pilot study and two experiments, the authors investigated the efficacy of implementation intentions to replace unhealthy snacks with healthy snacks by linking different types of cues for unhealthy snacking (if-part) to healthy snacking (then-part). The pilot study identified cues for unhealthy snacking, differentiating between situational (where/when) and motivational (why) cues. Studies 1 and 2 tested the efficacy of implementation intentions that specified either situational or motivational cues in altering snacking habits. Results showed that implementation intentions specifying motivational cues decreased unhealthy snack consumption whereas the classic specification of where and when did not. Extending previous research, for complex behavior change "why" seems more important than "where and when."

Review of sentinel node procedure in cN0 head and neck squamous cell carcinomas. Guidelines from the French evaluation cooperative subgroup of GETTEC.

PubMed

Garrel, R; Poissonnet, G; Temam, S; Dolivet, G; Fakhry, N; de Raucourt, D

2017-04-01

The reliability of the sentinel lymph node (SN) technique has been established for more than ten years in T1-T2 oral cavity and oropharynx squamous cell carcinoma. Although most authors stress the necessity of rigorous implementation, there are no agreed guidelines. Moreover, other indications have been described, in other anatomical areas of the upper aerodigestive tract and in case of previous surgery or radiotherapy. SN expert teams, under the GETTEC head and neck tumor study group, conducted a review of the key points for implementation in head and neck cancers through guidelines and a review of classical and extended indications. Reliability depends on respecting key points of preoperative landmarking by lymphoscintigraphy, and intraoperative SN sampling and histological analysis. The SN technique is the best means of diagnosing occult lymph node involvement, whatever the primary tumor location, T stage or patient history. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

The role of motivation, responsibility, and integrative complexity in crisis escalation: comparative studies of war and peace crises.

PubMed

Winter, David G

2007-05-01

Drawing on D. G. Winter's (1993) comparison of 1914 and the Cuban Missile Crisis, the author identified 8 paired crises (1 escalating to war, 1 peacefully resolved). Documents (diplomatic messages, speeches, official media commentary) from each crisis were scored for power, affiliation, and achievement motivation; text measures of responsibility and activity inhibition; and integrative complexity. Aggregated effect-size results show that war crises had significantly higher levels of power motivation and responsibility, whereas peace crises showed trends toward higher integrative complexity and achievement motivation. Follow-up analyses suggested that these results are robust with respect to both sides in a crisis, type of material scored, and historical time. The power motive results extend previous findings, but the responsibility results suggest that responsibility plays a paradoxical role in war. Future research directions are sketched, and the role of psychological content analysis in monitoring the danger of war is discussed. ((c) 2007 APA, all rights reserved).

Extending Previous cG×I Findings on 5-HTTLPR's Moderation of Intervention Effects on Adolescent Substance Misuse Initiation.

PubMed

Schlomer, Gabriel L; Cleveland, H Harrington; Feinberg, Mark E; Wolf, Pedro S A; Greenberg, Mark T; Spoth, Richard L; Redmond, Cleve; Tricou, Eric P; Vandenbergh, David J

2017-11-01

This study addresses replication in candidate gene × environment interaction (cG×E) research by investigating if the key findings from Brody, Beach, Philibert, Chen, and Murry (2009) can be detected using data (N = 1,809) from the PROSPER substance use preventive intervention delivery system. Parallel to Brody et al., this study tested the hypotheses that substance misuse initiation would increase faster from age 11 to age 14 and be higher at age 14 among: (a) 5-HTTLPR short carrier adolescents versus long homozygotes, (b) control versus intervention adolescents, and (c) 5-HTTLPR short carriers in the control condition versus all other participants. The hypotheses were generally supported and results were consistent with Brody et al.'s cG×I finding. Results are discussed in light of replication issues in cG×E research and implications for intervention. © 2016 The Authors. Child Development © 2016 Society for Research in Child Development, Inc.

The tale of hearts and reason: the influence of mood on decision making.

PubMed

Laborde, Sylvain; Raab, Markus

2013-08-01

In decision-making research, one important aspect of real-life decisions has so far been neglected: the mood of the decision maker when generating options. The authors tested the use of the take-the-first (TTF) heuristic and extended the TTF model to understand how mood influences the option-generation process of individuals in two studies, the first using a between-subjects design (30 nonexperts, 30 near-experts, and 30 experts) and the second conceptually replicating the first using a within-subject design (30 nonexperts). Participants took part in an experimental option-generation task, with 31 three-dimensional videos of choices in team handball. Three moods were elicited: positive, neutral, and negative. The findings (a) replicate previous results concerning TTF and (b) show that the option-generation process was associated with the physiological component of mood, supporting the neurovisceral integration model. The extension of TTF to processing emotional factors is an important step forward in explaining fast choices in real-life situations.

Facial resemblance to emotions: group differences, impression effects, and race stereotypes.

PubMed

Zebrowitz, Leslie A; Kikuchi, Masako; Fellous, Jean-Marc

2010-02-01

The authors used connectionist modeling to extend previous research on emotion overgeneralization effects. Study 1 demonstrated that neutral expression male faces objectively resemble angry expressions more than female faces do, female faces objectively resemble surprise expressions more than male faces do, White faces objectively resemble angry expressions more than Black or Korean faces do, and Black faces objectively resemble happy and surprise expressions more than White faces do. Study 2 demonstrated that objective resemblance to emotion expressions influences trait impressions even when statistically controlling possible confounding influences of attractiveness and babyfaceness. It further demonstrated that emotion overgeneralization is moderated by face race and that racial differences in emotion resemblance contribute to White perceivers' stereotypes of Blacks and Asians. These results suggest that intergroup relations may be strained not only by cultural stereotypes but also by adaptive responses to emotion expressions that are overgeneralized to groups whose faces subtly resemble particular emotions. Copyright 2009 APA, all rights reserved

Phonetic imitation by young children and its developmental changes.

PubMed

Nielsen, Kuniko

2014-12-01

In the current study, the author investigated the developmental course of phonetic imitation in childhood, and further evaluated existing accounts of phonetic imitation. Sixteen preschoolers, 15 third graders, and 18 college students participated in the current study. An experiment with a modified imitation paradigm with a picture-naming task was conducted, in which participants' voice-onset time (VOT) was compared before and after they were exposed to target speech with artificially increased VOT. Extended VOT in the target speech was imitated by preschoolers and 3rd graders as well as adults, confirming previous findings in phonetic imitation. Furthermore, an age effect of phonetic imitation was observed; namely, children showed greater imitation than adults, whereas the degree of imitation was comparable between preschoolers and 3rd graders. No significant effect of gender or word specificity was observed. Young children imitated fine phonetic details of the target speech, and greater degree of phonetic imitation was observed in children compared to adults. These findings suggest that the degree of phonetic imitation negatively correlates with phonological development.

Euclidean perspective on the unfolding of azurin: angular correlations

NASA Astrophysics Data System (ADS)

Warren, Jeffrey J.; Gray, Harry B.; Winkler, Jay R.; Kozak, John J.

2013-12-01

The geometrical model introduced previously by the authors has been extended quantitatively to document changes in angular correlations between and among residues as azurin unfolds. In the early stages of denaturation, these changes are found to be more pronounced than changes in the spatial displacement of residues, a result that is also found for residues acting in concert, viz., α-helices, β-sheet residues and residues in 'turning regions.' Our analysis leads to a picture of the large-scale motion of the polypeptide chain as azurin denatures. Flanking a central 'ribbon' of residues whose orientation remains essentially invariant, we find that in the early stages of unfolding, left- and right-hand 'wings' adjacent to this stationary scaffolding pivot counterclockwise, while smaller regions on opposing ends of the β-barrel pivot clockwise. As spatial constraints characterising the native state are further relaxed, our calculations show that some regions reverse their orientational motion, reflecting the enhanced flexibility of the polypeptide chain in the denatured state.

Computing approximate random Delta v magnitude probability densities. [for spacecraft trajectory correction

NASA Technical Reports Server (NTRS)

Chadwick, C.

1984-01-01

This paper describes the development and use of an algorithm to compute approximate statistics of the magnitude of a single random trajectory correction maneuver (TCM) Delta v vector. The TCM Delta v vector is modeled as a three component Cartesian vector each of whose components is a random variable having a normal (Gaussian) distribution with zero mean and possibly unequal standard deviations. The algorithm uses these standard deviations as input to produce approximations to (1) the mean and standard deviation of the magnitude of Delta v, (2) points of the probability density function of the magnitude of Delta v, and (3) points of the cumulative and inverse cumulative distribution functions of Delta v. The approximates are based on Monte Carlo techniques developed in a previous paper by the author and extended here. The algorithm described is expected to be useful in both pre-flight planning and in-flight analysis of maneuver propellant requirements for space missions.

French law: what about a reasoned reimbursement of serum vitamin D assays?

PubMed

Souberbielle, Jean-Claude; Benhamou, Claude Laurent; Cortet, Bernard; Rousière, Mickael; Roux, Christian; Abitbol, Vered; Annweiler, Cédric; Audran, Maurice; Bacchetta, Justine; Bataille, Pierre; Beauchet, Olivier; Bardet, Rémi; Benachi, Alexandra; Berenbaum, Francis; Blain, Hubert; Borson-Chazot, Françoise; Breuil, Véronique; Briot, Karine; Brunet, Philippe; Carel, Jean-Claude; Caron, Philippe; Chabre, Olivier; Chanson, Philippe; Chapurlat, Roland; Cochat, Pierre; Coutant, Régis; Christin-Maitre, Sophie; Cohen-Solal, Martine; Combe, Christian; Cormier, Catherine; Courbebaisse, Marie; Debrus, Grégory; Delemer, Brigitte; Deschenes, Georges; Duquenne, Marc; Duval, Guillaume; Fardellone, Patrice; Fouque, Denis; Friedlander, Gérard; Gauvain, Jean-Bernard; Groussin, Lionel; Guggenbuhl, Pascal; Houillier, Pascal; Hannedouche, Thierry; Jacot, William; Javier, Rose-Marie; Jean, Guillaume; Jeandel, Claude; Joly, Dominique; Kamenicky, Peter; Knebelmann, Bertrand; Lafage-Proust, Marie-Hélène; LeBouc, Yves; Legrand, Erick; Levy-Weil, Florence; Linglart, Agnès; Machet, Laurent; Maheu, Emmanuel; Mallet, Eric; Marcelli, Christian; Marès, Pierre; Mariat, Christophe; Maruani, Gérard; Maugars, Yves; Montagnon, France; Moulin, Bruno; Orcel, Philippe; Partouche, Henri; Personne, Virginie; Pierrot-Deseilligny, Charles; Polak, Michel; Pouteil-Noble, Claire; Prié, Dominique; Raynaud-Simon, Agathe; Rolland, Yves; Sadoul, Jean-Louis; Salle, Bernard; Sault, Corinne; Schott, Anne-Marie; Sermet-Gaudelus, Isabelle; Soubrier, Martin; Tack, Ivan; Thervet, Eric; Tostivint, Isabelle; Touraine, Philippe; Tremollières, Florence; Urena-Torres, Pablo; Viard, Jean-Paul; Wemeau, Jean-Louis; Weryha, Georges; Winer, Norbert; Young, Jacques; Thomas, Thierry

2016-12-01

The number of serum 25-hydroxyvitamin D (25OHD) assays has increased tenfold in France in less than 10 years, sometimes for invalidated reasons. In 2013, the French National Authority for Health (Haute autorité de santé, or HAS) limited the indications for serum 25OHD measurements to rickets/osteomalacia, older adults with recurrent falls, monitoring of kidney transplant in adults, and surgical treatment of obesity in adults. Our aim here was to note that other indications for serum 25OHD measurements are supported by previous literature and by a number of national and international recommendations, in particular the following: any situation of bone fragility, any chronic renal failure <45 mL/min/1.73m 2 , any situation of malabsorption, clinical signs consistent with vitamin D deficiency or vitamin D overload, and calcium phosphorus evaluation. We suggest that the measurement of serum 25OHD concentration should remain reimbursed as part of these extended indications.

"Not Homeless Yet. I'm Kind of Couch Surfing": Finding Identities for People at a Homeless Shelter.

PubMed

Terui, Sachiko; Hsieh, Elaine

2016-01-01

The meanings of homelessness are fluid and socially constructed, providing resources and limitations for individuals to negotiate their identities and relationships in everyday life. In this study, we examine the strategies and corresponding resources utilized by people who are homeless to cope with the labeling of a homeless identity and to redefine their identities. We used constant comparative analysis to examine in-depth interviews with 16 participants (male = 11, female = 5) who access a local homeless shelter in the southwest United States for resources. We identified three strategies that homeless people adopt to cope with the labeling of homeless identity: (a) differentiating oneself from others who are homeless, (b) prioritizing certain aspects of life, and (c) embracing the status of homelessness. Although these strategies have been identified in previous literature, the authors extend this line of research by identifying the common resources people who are homeless utilize when adopting these strategies, which entail important implications for theory development and practical implications.

A common variant near TGFBR3 is associated with primary open angle glaucoma.

PubMed

Li, Zheng; Allingham, R Rand; Nakano, Masakazu; Jia, Liyun; Chen, Yuhong; Ikeda, Yoko; Mani, Baskaran; Chen, Li-Jia; Kee, Changwon; Garway-Heath, David F; Sripriya, Sarangapani; Fuse, Nobuo; Abu-Amero, Khaled K; Huang, Chukai; Namburi, Prasanthi; Burdon, Kathryn; Perera, Shamira A; Gharahkhani, Puya; Lin, Ying; Ueno, Morio; Ozaki, Mineo; Mizoguchi, Takanori; Krishnadas, Subbiah Ramasamy; Osman, Essam A; Lee, Mei Chin; Chan, Anita S Y; Tajudin, Liza-Sharmini A; Do, Tan; Goncalves, Aurelien; Reynier, Pascal; Zhang, Hong; Bourne, Rupert; Goh, David; Broadway, David; Husain, Rahat; Negi, Anil K; Su, Daniel H; Ho, Ching-Lin; Blanco, Augusto Azuara; Leung, Christopher K S; Wong, Tina T; Yakub, Azhany; Liu, Yutao; Nongpiur, Monisha E; Han, Jong Chul; Hon, Do Nhu; Shantha, Balekudaru; Zhao, Bowen; Sang, Jinghong; Zhang, NiHong; Sato, Ryuichi; Yoshii, Kengo; Panda-Jonas, Songhomita; Ashley Koch, Allison E; Herndon, Leon W; Moroi, Sayoko E; Challa, Pratap; Foo, Jia Nee; Bei, Jin-Xin; Zeng, Yi-Xin; Simmons, Cameron P; Bich Chau, Tran Nguyen; Sharmila, Philomenadin Ferdinamarie; Chew, Merwyn; Lim, Blanche; Tam, Pansy O S; Chua, Elaine; Ng, Xiao Yu; Yong, Victor H K; Chong, Yaan Fun; Meah, Wee Yang; Vijayan, Saravanan; Seongsoo, Sohn; Xu, Wang; Teo, Yik Ying; Cooke Bailey, Jessica N; Kang, Jae H; Haines, Jonathan L; Cheng, Ching Yu; Saw, Seang-Mei; Tai, E-Shyong; Richards, Julia E; Ritch, Robert; Gaasterland, Douglas E; Pasquale, Louis R; Liu, Jianjun; Jonas, Jost B; Milea, Dan; George, Ronnie; Al-Obeidan, Saleh A; Mori, Kazuhiko; Macgregor, Stuart; Hewitt, Alex W; Girkin, Christopher A; Zhang, Mingzhi; Sundaresan, Periasamy; Vijaya, Lingam; Mackey, David A; Wong, Tien Yin; Craig, Jamie E; Sun, Xinghuai; Kinoshita, Shigeru; Wiggs, Janey L; Khor, Chiea-Chuen; Yang, Zhenglin; Pang, Chi Pui; Wang, Ningli; Hauser, Michael A; Tashiro, Kei; Aung, Tin; Vithana, Eranga N

2015-07-01

Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we observed one SNP showing significant association to POAG (CDC7-TGFBR3 rs1192415, ORG-allele = 1.13, Pmeta = 1.60 × 10(-8)). This particular SNP has previously been shown to be strongly associated with optic disc area and vertical cup-to-disc ratio, which are regarded as glaucoma-related quantitative traits. Our study now extends this by directly implicating it in POAG disease pathogenesis. © The Author 2015. Published by Oxford University Press.

Emission spectra from ZnS:Mn due to low velocity impacts

NASA Astrophysics Data System (ADS)

Hollerman, W. A.; Goedeke, S. M.; Bergeron, N. P.; Moore, R. J.; Allison, S. W.; Lewis, L. A.

2005-09-01

Triboluminescence (TL) is the emission of light due to crystal fracture and has been known for centuries. One of the most common examples of TL is the flash created from chewing wintergreen Lifesavers. Since 2003, the authors have been measuring triboluminescent properties of phosphors, of which zinc sulfide doped with manganese (ZnS:Mn) is an example. Preliminary results indicate that impact velocities greater than 0.5 m/s produce measurable TL from ZnS:Mn. To extend this research, the investigation of the emission spectrum was chosen. This differs from using filtered photodetectors in that the spectral composition of fluorescence can be ascertained. Previous research has utilized a variety of schemes that include scratching, crushing, and grinding to generate TL. In our case, the material is activated by a short duration interaction of a dropped mass and a small number of luminescence centers. This research provides a basis for the characterization and selection of materials for future spacecraft impact detection schemes.

Ethanol acts as an enhancer of steroid anesthetic activity in mouse

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bukusoglu, C.; Mok, W.M.; Krieger, N.R.

1992-02-26

Ethanol and the steroid 3{alpha}-hydroxy-5{alpha}-pregnan-20-one (3{alpha}) are each potent general anesthetics that bring about the rapid loss of the righting response (LRR) in mice. Ethanol is known to enhance the actions of a range of sedative and anesthetic agents. However the effects of ethanol on steroid anesthesia have not previously been described. When ethanol was co-injected with 3{alpha} as compared to 3{alpha} injected alone, the percentage of mice that lost the righting response was substantially increased; the time to LRR was shortened; and 3{alpha} brain levels were increased. The interactions between the two agents were analyzed with the aid ofmore » an isobologram and they were found to be consistent with a hypothesis of additivity. The authors speculate that the role of ethanol as an enhancer of administered 3{alpha} activity described here may extend to the enhancement of endogenous 3{alpha} activity.« less

Further links between the maximum hardness principle and the hard/soft acid/base principle: insights from hard/soft exchange reactions.

PubMed

Chattaraj, Pratim K; Ayers, Paul W; Melin, Junia

2007-08-07

Ayers, Parr, and Pearson recently showed that insight into the hard/soft acid/base (HSAB) principle could be obtained by analyzing the energy of reactions in hard/soft exchange reactions, i.e., reactions in which a soft acid replaces a hard acid or a soft base replaces a hard base [J. Chem. Phys., 2006, 124, 194107]. We show, in accord with the maximum hardness principle, that the hardness increases for favorable hard/soft exchange reactions and decreases when the HSAB principle indicates that hard/soft exchange reactions are unfavorable. This extends the previous work of the authors, which treated only the "double hard/soft exchange" reaction [P. K. Chattaraj and P. W. Ayers, J. Chem. Phys., 2005, 123, 086101]. We also discuss two different approaches to computing the hardness of molecules from the hardness of the composing fragments, and explain how the results differ. In the present context, it seems that the arithmetic mean of fragment softnesses is the preferable definition.

A precise measurement of the magnetic field in the corona of the black hole binary V404 Cygni.

PubMed

Dallilar, Yigit; Eikenberry, Stephen S; Garner, Alan; Stelter, Richard D; Gottlieb, Amy; Gandhi, Poshak; Casella, Piergiorgio; Dhillon, Vik S; Marsh, Tom R; Littlefair, Stuart P; Hardy, Liam; Fender, Rob; Mooley, Kunal; Walton, Dominic J; Fuerst, Felix; Bachetti, Matteo; Castro-Tirado, A J; Charcos, Miguel; Edwards, Michelle L; Lasso-Cabrera, Nestor M; Marin-Franch, Antonio; Raines, S Nicholas; Ackley, Kendall; Bennett, John G; Cenarro, A Javier; Chinn, Brian; Donoso, H Veronica; Frommeyer, Raymond; Hanna, Kevin; Herlevich, Michael D; Julian, Jeff; Miller, Paola; Mullin, Scott; Murphey, Charles H; Packham, Chris; Varosi, Frank; Vega, Claudia; Warner, Craig; Ramaprakash, A N; Burse, Mahesh; Punnadi, Sujit; Chordia, Pravin; Gerarts, Andreas; de Paz Martín, Héctor; Calero, María Martín; Scarpa, Riccardo; Acosta, Sergio Fernandez; Hernández Sánchez, William Miguel; Siegel, Benjamin; Pérez, Francisco Francisco; Viera Martín, Himar D; Rodríguez Losada, José A; Nuñez, Agustín; Tejero, Álvaro; Martín González, Carlos E; Rodríguez, César Cabrera; Molgó, Jordi; Rodriguez, J Esteban; Cáceres, J Israel Fernández; Rodríguez García, Luis A; Lopez, Manuel Huertas; Dominguez, Raul; Gaggstatter, Tim; Lavers, Antonio Cabrera; Geier, Stefan; Pessev, Peter; Sarajedini, Ata

2017-12-08

Observations of binary stars containing an accreting black hole or neutron star often show x-ray emission extending to high energies (>10 kilo--electron volts), which is ascribed to an accretion disk corona of energetic particles akin to those seen in the solar corona. Despite their ubiquity, the physical conditions in accretion disk coronae remain poorly constrained. Using simultaneous infrared, optical, x-ray, and radio observations of the Galactic black hole system V404 Cygni, showing a rapid synchrotron cooling event in its 2015 outburst, we present a precise 461 ± 12 gauss magnetic field measurement in the corona. This measurement is substantially lower than previous estimates for such systems, providing constraints on physical models of accretion physics in black hole and neutron star binary systems. Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Output-feedback control of combined sewer networks through receding horizon control with moving horizon estimation

NASA Astrophysics Data System (ADS)

Joseph-Duran, Bernat; Ocampo-Martinez, Carlos; Cembrano, Gabriela

2015-10-01

An output-feedback control strategy for pollution mitigation in combined sewer networks is presented. The proposed strategy provides means to apply model-based predictive control to large-scale sewer networks, in-spite of the lack of measurements at most of the network sewers. In previous works, the authors presented a hybrid linear control-oriented model for sewer networks together with the formulation of Optimal Control Problems (OCP) and State Estimation Problems (SEP). By iteratively solving these problems, preliminary Receding Horizon Control with Moving Horizon Estimation (RHC/MHE) results, based on flow measurements, were also obtained. In this work, the RHC/MHE algorithm has been extended to take into account both flow and water level measurements and the resulting control loop has been extensively simulated to assess the system performance according different measurement availability scenarios and rain events. All simulations have been carried out using a detailed physically based model of a real case-study network as virtual reality.

A Bayesian Approach for Measurements of Stray Neutrons at Proton Therapy Facilities: Quantifying Neutron Dose Uncertainty.

PubMed

Dommert, M; Reginatto, M; Zboril, M; Fiedler, F; Helmbrecht, S; Enghardt, W; Lutz, B

2017-11-28

Bonner sphere measurements are typically analyzed using unfolding codes. It is well known that it is difficult to get reliable estimates of uncertainties for standard unfolding procedures. An alternative approach is to analyze the data using Bayesian parameter estimation. This method provides reliable estimates of the uncertainties of neutron spectra leading to rigorous estimates of uncertainties of the dose. We extend previous Bayesian approaches and apply the method to stray neutrons in proton therapy environments by introducing a new parameterized model which describes the main features of the expected neutron spectra. The parameterization is based on information that is available from measurements and detailed Monte Carlo simulations. The validity of this approach has been validated with results of an experiment using Bonner spheres carried out at the experimental hall of the OncoRay proton therapy facility in Dresden. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

An extended BET format for La RC shuttle experiments: Definition and development

NASA Technical Reports Server (NTRS)

Findlay, J. T.; Kelly, G. M.; Henry, M. W.

1981-01-01

A program for shuttle post-flight data reduction is discussed. An extended Best Estimate Trajectory (BET) file was developed. The extended format results in some subtle changes to the header record. The major change is the addition of twenty-six words to each data record. These words include atmospheric related parameters, body axis rate and acceleration data, computed aerodynamic coefficients, and angular accelerations. These parameters were added to facilitate post-flight aerodynamic coefficient determinations as well as shuttle entry air data sensor analyses. Software (NEWBET) was developed to generate the extended BET file utilizing the previously defined ENTREE BET, a dynamic data file which may be either derived inertial measurement unit data or aerodynamic coefficient instrument package data, and some atmospheric information.

Broadband dielectric spectroscopy on single-crystalline and ceramic CaCu3Ti4O12

NASA Astrophysics Data System (ADS)

Krohns, S.; Lunkenheimer, P.; Ebbinghaus, S. G.; Loidl, A.

2007-07-01

The authors present dielectric measurements of the colossal dielectric constant material CaCu3Ti4O12 extending up to 1.3GHz also covering so far only rarely investigated single-crystalline samples. Special emphasis is put on the second relaxation reported in several works on polycrystals, which the authors detect also in single crystals. For polycrystalline samples, the authors provide a recipe to achieve values of the dielectric constant as high as in single crystals.

Biotransformation and bioactivation reactions - 2016 literature highlights.

PubMed

Khojasteh, S Cyrus; Rietjens, Ivonne M C M; Dalvie, Deepak; Miller, Grover

2017-08-01

We are pleased to present a second annual issue highlighting a previous year's literature on biotransformation and bioactivation. Each contributor to this issue worked independently to review the articles published in 2016 and proposed three to four articles, which he or she believed would be of interest to the broader research community. In each synopsis, the contributing author summarized the procedures, analyses and conclusions as described in the original manuscripts. In the commentary sections, our authors offer feedback and highlight aspects of the work that may not be apparent from an initial reading of the article. To be fair, one should still read the original article to gain a more complete understanding of the work conducted. Most of the articles included in this review were published in Drug Metabolism and Disposition or Chemical Research in Toxicology, but attempts were made to seek articles in 25 other journals. Importantly, these articles are not intended to represent a consensus of the best papers of the year, as we did not want to make any arbitrary standards for this purpose, but rather they were chosen by each author for their notable findings and descriptions of novel metabolic pathways or biotransformations. I am pleased that Drs. Rietjens and Dalvie have again contributed to this annual review. We would like to welcome Grover P Miller as an author for this year's issue, and we thank Tom Baillie for his contributions to last year's edition. We have intentionally maintained a balance of authors such that two come from an academic setting and two come from industry. Finally, please drop us a note if you find this review helpful. We would be pleased to hear your opinions of our commentary, and we extend an invitation to anyone who would like to contribute to a future edition of this review. This article is dedicated to Professor Thomas Baillie for his exceptional contributions to the field of drug metabolism.

ORCA Project: Research on high-performance parallel computer programming environments. Final report, 1 Apr-31 Mar 90

DOE Office of Scientific and Technical Information (OSTI.GOV)

Snyder, L.; Notkin, D.; Adams, L.

1990-03-31

This task relates to research on programming massively parallel computers. Previous work on the Ensamble concept of programming was extended and investigation into nonshared memory models of parallel computation was undertaken. Previous work on the Ensamble concept defined a set of programming abstractions and was used to organize the programming task into three distinct levels; Composition of machine instruction, composition of processes, and composition of phases. It was applied to shared memory models of computations. During the present research period, these concepts were extended to nonshared memory models. During the present research period, one Ph D. thesis was completed, onemore » book chapter, and six conference proceedings were published.« less

From Rhetoric to Action: From Words to Deeds--Closing Keynote Address to CONFINTEA VI

ERIC Educational Resources Information Center

Belanger, Paul

2012-01-01

In this keynote address, the author explains why it is important to advance the right to lifelong learning and extend education throughout life. The author stresses that the continuing development of knowledge and skills within the adult population is one of the most strategic investments that societies must make today. Furthermore, this is an…

Interdependence and Integration Learning in Student Project Teams: Do Team Project Assignments Achieve What We Want Them to?

ERIC Educational Resources Information Center

Skilton, Paul F.; Forsyth, David; White, Otis J.

2008-01-01

Building from research on learning in workplace project teams, the authors work forward from the idea that the principal condition enabling integration learning in student team projects is project complexity. Recognizing the challenges of developing and running complex student projects, the authors extend theory to propose that the experience of…

Teachers' Rights versus Students' Rights: Race and Professional Authority in the New York City Public Schools, 1960-1986

ERIC Educational Resources Information Center

D'Amico, Diana

2016-01-01

In 1968, New York City's unionized teachers participated in three separate strikes that spanned two school years. Teachers clashed with Black parents and activists who called for community control as both groups sought authority and recognition in the schools. Racialized assumptions in place before and extending beyond the labor skirmish infused…

Just Perfect, Part 2

ERIC Educational Resources Information Center

Scott, Paul

2007-01-01

In "Just Perfect: Part 1," the author defined a perfect number N to be one for which the sum of the divisors d (1 less than or equal to d less than N) is N. He gave the first few perfect numbers, starting with those known by the early Greeks. In this article, the author provides an extended list of perfect numbers, with some comments about their…

Body Beautiful, Beautiful Body: The Curricular Encounters of Gay Men Living with HIV

ERIC Educational Resources Information Center

Malewski, Erik

2012-01-01

Through this article the author extends the study of the curricular body and mothering curriculum initiated by Stephanie Springgay and Deborah Freedman with a study into the embodied experiences of gay men living with HIV. In the first section, the author focuses on difference as embodiment before and after HIV in order to craft analytic frames of…

The System of Systems Architecture Feasibility Assessment Model

DTIC Science & Technology

2016-06-01

OF SYSTEMS ARCHITECTURE FEASIBILITY ASSESSMENT MODEL by Stephen E. Gillespie June 2016 Dissertation Supervisor Eugene Paulo THIS PAGE...Dissertation 4. TITLE AND SUBTITLE THE SYSTEM OF SYSTEMS ARCHITECTURE FEASIBILITY ASSESSMENT MODEL 5. FUNDING NUMBERS 6. AUTHOR(S) Stephen E...SoS architecture feasibility assessment model (SoS-AFAM). Together, these extend current model- based systems engineering (MBSE) and SoS engineering

Reflective Writing and Life-Career Planning: Extending the Learning in a Learning Community Model

ERIC Educational Resources Information Center

Nownes, Nicholas; Stebleton, Michael

2010-01-01

This essay recounts the authors' experiences as community college faculty members in a learning community (LC) linking first-year composition with a class in life-career planning and development. The authors begin with a learning community story shared recently over drinks with a group of community college English teachers. They use the story to…

Population of anatomically variable 4D XCAT adult phantoms for imaging research and optimization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Segars, W. P.; Bond, Jason; Frush, Jack

2013-04-15

Purpose: The authors previously developed the 4D extended cardiac-torso (XCAT) phantom for multimodality imaging research. The XCAT consisted of highly detailed whole-body models for the standard male and female adult, including the cardiac and respiratory motions. In this work, the authors extend the XCAT beyond these reference anatomies by developing a series of anatomically variable 4D XCAT adult phantoms for imaging research, the first library of 4D computational phantoms. Methods: The initial anatomy of each phantom was based on chest-abdomen-pelvis computed tomography data from normal patients obtained from the Duke University database. The major organs and structures for each phantommore » were segmented from the corresponding data and defined using nonuniform rational B-spline surfaces. To complete the body, the authors manually added on the head, arms, and legs using the original XCAT adult male and female anatomies. The structures were scaled to best match the age and anatomy of the patient. A multichannel large deformation diffeomorphic metric mapping algorithm was then used to calculate the transform from the template XCAT phantom (male or female) to the target patient model. The transform was applied to the template XCAT to fill in any unsegmented structures within the target phantom and to implement the 4D cardiac and respiratory models in the new anatomy. Each new phantom was refined by checking for anatomical accuracy via inspection of the models. Results: Using these methods, the authors created a series of computerized phantoms with thousands of anatomical structures and modeling cardiac and respiratory motions. The database consists of 58 (35 male and 23 female) anatomically variable phantoms in total. Like the original XCAT, these phantoms can be combined with existing simulation packages to simulate realistic imaging data. Each new phantom contains parameterized models for the anatomy and the cardiac and respiratory motions and can, therefore, serve as a jumping point from which to create an unlimited number of 3D and 4D variations for imaging research. Conclusions: A population of phantoms that includes a range of anatomical variations representative of the public at large is needed to more closely mimic a clinical study or trial. The series of anatomically variable phantoms developed in this work provide a valuable resource for investigating 3D and 4D imaging devices and the effects of anatomy and motion in imaging. Combined with Monte Carlo simulation programs, the phantoms also provide a valuable tool to investigate patient-specific dose and image quality, and optimization for adults undergoing imaging procedures.« less

Plasma melatonin circadian rhythms during the menstrual cycle and after light therapy in premenstrual dysphoric disorder and normal control subjects.

PubMed

Parry, B L; Berga, S L; Mostofi, N; Klauber, M R; Resnick, A

1997-02-01

The aim of this study was to replicate and extend previous work in which the authors observed lower, shorter, and advanced nocturnal melatonin secretion patterns in premenstrually depressed patients compared to those in healthy control women. The authors also sought to test the hypothesis that the therapeutic effect of bright light in patients was associated with corrective effects on the phase, duration, and amplitude of melatonin rhythms. In 21 subjects with premenstrual dysphoric disorder (PMDD) and 11 normal control (NC) subjects, the authors measured the circadian profile of melatonin during follicular and luteal menstrual cycle phases and after 1 week of light therapy administered daily, in a randomized crossover design. During three separate luteal phases, the treatments were either (1) bright (> 2,500 lux) white morning (AM; 06:30 to 08:30 h), (2) bright white evening (PM; 19:00 to 21:00 h), or (3) dim (< 10 lux) red evening light (RED). In PMDD subjects, during the luteal phase compared to the follicular menstrual cycle phase, melatonin onset time was delayed, duration was compressed, and area under the curve, amplitude, and mean levels were decreased. In NC subjects, melatonin rhythms did not change significantly during the menstrual cycle. After AM light in PMDD subjects, onset and offset times were advanced and both duration and midpoint concentration were decreased as compared to RED light. After PM light in PMDD subjects, onset and offset times were delayed, midpoint concentration was increased, and duration was decreased as compared to RED light. By contrast, after light therapy in NC subjects, duration did not change; onset, offset, and midpoint concentration changed as they did in PMDD subjects. When the magnitude of advance and delay phase shifts in onset versus offset time with AM, PM, or RED light were compared, the authors found that in PMDD subjects light shifted offset time more than onset time and that AM light had a greater effect on shifting melatonin offset time (measured the following night in RED light), whereas PM light had a greater effect in shifting melatonin onset time. These findings replicate the authors' previous observation that nocturnal melatonin concentrations are decreased in women with PMDD and suggest specific effects of light therapy on melatonin circadian rhythms that are associated with mood changes in patient versus control groups. The differential changes in onset and offset times during the menstrual cycle, and in response to AM and PM bright light compared with RED light, support a two-oscillator (complex) model of melatonin regulation in humans.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Williams, Samuel; Patterson, David; Oliker, Leonid

This article consists of a collection of slides from the authors' conference presentation. The Roofline model is a visually intuitive figure for kernel analysis and optimization. We believe undergraduates will find it useful in assessing performance and scalability limitations. It is easily extended to other architectural paradigms. It is easily extendable to other metrics: performance (sort, graphics, crypto..) bandwidth (L2, PCIe, ..). Furthermore, a performance counters could be used to generate a runtime-specific roofline that would greatly aide the optimization.

Energy Efficiency and Renewable Energy Legislation in the 109th Congress

DTIC Science & Technology

2006-08-14

law November 19. H.R. 2498 ( Hulshof )/S. 1076 (Lincoln) Extends through December 31, 2010, the tax credit for biodiesel used as fuel and the excise...Resources. H.R. 5650 ( Hulshof ) Renewable Fuels and Energy Independence Promotion Act of 2006. The bill would make permanent certain tax incentives for...Committee on Armed Services. Includes $60 million authorization. Reported (S.Rept. 109-69) May 17. S. 1076 (Lincoln)/H.R. 2498 ( Hulshof ) Extends

Hospital variation in allogeneic transfusion and extended length of stay in primary elective hip and knee arthroplasty: a cross-sectional study.

PubMed

Voorn, Veronique M A; Marang-van de Mheen, Perla J; van der Hout, Anja; So-Osman, Cynthia; van den Akker-van Marle, M Elske; Koopman-van Gemert, Ankie W M M; Dahan, Albert; Vliet Vlieland, Thea P M; Nelissen, Rob G H H; van Bodegom-Vos, Leti

2017-07-20

Outcomes in total hip and knee arthroplasty (THA and TKA), such as allogeneic transfusions or extended length of stay (LoS), can be used to compare the performance of hospitals. However, there is much variation in these outcomes. This study aims to rank hospitals and to assess hospital differences of two outcomes in THA and TKA: allogeneic transfusions and extended LoS, and to additionally identify factors associated with these differences. Cross-sectional medical record review study. Data were gathered in 23 Dutch hospitals. 1163 THA and 986 TKA patient admissions. Hospitals were ranked based on their observed/expected (O/E) ratios regarding allogeneic transfusion and extended LoS percentages (extended LoS was defined by postoperative stay >4 days). To assess the reliability of these rankings, we calculated which percentage of the existing variation was based on differences between hospitals as compared with random variation (after adjustment for variation in patient characteristics). Associations between hospital-specific factors and O/E ratios were used to explore potential sources of differences. The variation in O/E ratios between hospitals ranged from 0 to 4.4 for allogeneic transfusion, and from 0.08 to 2.7 for extended LoS. Variation in transfusion could in 21% be explained by hospital differences in THA and 34% in TKA. For extended LoS this was 71% in THA and 78% in TKA. Better performance (low O/E ratios) in transfusion was associated with more frequent tranexamic acid (TXA) use in TKA (R=-0.43, p=0.04). Better performance in extended LoS was associated with more frequent TXA use in THA (R=-0.45, p=0.03) and TKA (R=-0.65, p<0.001) and local infiltration analgesia (LIA) in TKA (R=-0.60, p=0.002). Ranking hospitals based on allogeneic transfusion is unreliable due to small percentages of variation explained by hospital differences. Ranking based on extended LoS is more reliable. Hospitals using TXA and LIA have relatively fewer patients with transfusions and extended LoS. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Contract Service for School Maintenance

ERIC Educational Resources Information Center

Modern Schools, 1976

1976-01-01

Preventive maintenance can extend useful equipment life in a school building and keep systems running more efficiently. Points to consider before selecting a comprehensive energy management package are listed. (Author/MLF)

Extending the Use and Effectiveness of the Monopoly® Board Game as an In-Class Economic Simulation in the Introductory Financial Accounting Course

ERIC Educational Resources Information Center

Shanklin, Stephen B.; Ehlen, Craig R.

2017-01-01

This paper extends the use of the Monopoly® board game as an economic simulation exercise designed to reinforce an understanding of how the accounting cycle impacts the financial statements used to evaluate management performance. This extension adds elements of debt not previously utilized to allow for an introduction of the fundamentals of ratio…

Health Services for Domestic Agricultural Workers, 1972: S. 3762 -- To Extend the Program for Health Services for Domestic Agricultural Migrant Workers. Joint Hearing before the Subcommittee on Health and the Subcommittee on Migratory Labor of the Committee on Labor and Public Welfare, United States Senate, 92d Congress, 2d Session, August 1, 1972.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Senate Committee on Labor and Public Welfare.

On August 1, 1972, the Subcommittee heard testimony on bill S. 3762 which would extend the program for health services for domestic agricultural migrant workers. The bill would extend the migrant health program for 5 years, with $100 million authorized for fiscal year 1973 and a $25 million increase for each of the following years. S. 3762…

Extension of Effective Date for Temporary Pilot Program Setting the Time and Place for a Hearing Before an Administrative Law Judge. Final rule.

PubMed

2015-07-02

We are extending for one year our pilot program that authorizes the agency to set the time and place for a hearing before an administrative law judge (ALJ). Extending of the pilot program continues our commitment to improve the efficiency of our hearing process and to maintain a hearing process that results in accurate, high-quality decisions for claimants. The current pilot program will expire on August 10, 2015. In this final rule, we are extending the effective date to August 12, 2016. We are making no other substantive changes.

Student Participation in the College Classroom: An Extended Multidisciplinary Literature Review

ERIC Educational Resources Information Center

Rocca, Kelly A.

2010-01-01

The goal of this study was to integrate previous research conducted on student participation in the college classroom. Numerous studies have been completed on engaging students in classroom discussions, but no study has synthesized this information in the form of an extensive literature review. Here, previous research is pulled together to gain a…

Investigating the Receptive-Expressive Vocabulary Profile in Children with Idiopathic ASD and Comorbid ASD and Fragile X Syndrome

ERIC Educational Resources Information Center

Haebig, Eileen; Sterling, Audra

2017-01-01

Previous work has noted that some children with autism spectrum disorder (ASD) display weaknesses in receptive vocabulary relative to expressive vocabulary abilities. The current study extended previous work by examining the receptive-expressive vocabulary profile in boys with idiopathic ASD and boys with concomitant ASD and fragile X syndrome…

Psychometric Analysis of the Diagnostic Evaluation of Language Variation-Screening Test: Extension to Low-Income African American Pre-Kindergarteners

ERIC Educational Resources Information Center

Terry, Nicole P.; Petscher, Yaacov; Rhodes, Katherine T.

2017-01-01

The purpose of this study was to extend a previous investigation of the psychometrics of the "Diagnostic Evaluation of Language Variation-Screening Test" (DELV-S) to include pre-kindergarten children (primarily African American and from low-income households). The previous study (Petscher, Connor, & Al Otaiba, 2012) included a…

When Best Intentions Go Awry: The Failures of Concrete Representations to Help Solve Probability Word Problems

ERIC Educational Resources Information Center

Beitzel, Brian D.; Staley, Richard K.; DuBois, Nelson F.

2011-01-01

Previous research has cast doubt on the efficacy of utilizing external representations as an aid to solving word problems. The present study replicates previous findings that concrete representations hinder college students' ability to solve probability word problems, and extends those findings to apply to a multimedia instructional context. Our…

Transformational Leadership and Organizational Citizenship Behavior in the Arab Educational System in Israel: The Impact of Trust and Job Satisfaction

ERIC Educational Resources Information Center

Nasra, Muhammed Abu; Heilbrunn, Sibylle

2016-01-01

The present study aims to extend and integrate previous research on the mediating effects of trust in supervisor and job satisfaction on the relationship between transformational leadership style and organizational citizenship behavior (OCB). Drawing on previous research, we argue that transformational leadership impacts OCB directly and…

New Lepidoptera records for the Blue Mountains of eastern Oregon.

Treesearch

David G. Grimble; Roy C. Beckwith; Paul C. Hammond

1993-01-01

Black-light trap collections in mixed-coniferous forests in eastern Oregon resulted in the identification of one Arctiidae, six Noctuidae, and one Geometridae species not previously known to occur in Oregon. The ranges of 18 other species of Noctuidae, known previously in Oregon from only the Cascade and Coast Ranges, were extended to northeastern Oregon.

75 FR 57844 - Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

... inserting a copy of this AD into the AFM. ``MAXIMUM AIR BRAKES OPERATION/EXTENDED SPEED 360 KIAS/0.79 Mi NOTE During emergency, air brakes may be used at speeds above 0.79 M i. '' Note 1: When a statement... Airworthiness Directives; Gulfstream Aerospace LP (Type Certificate Previously Held by Israel Aircraft...

Further Evidence That Creativity and Innovation Are Inhibited by Conservative Thinking: Analyses of the 2016 Presidential Election

ERIC Educational Resources Information Center

Runco, Mark A.; Acar, Selcuk; Cayirdag, Nur

2017-01-01

The investigation replicated and extended previous research showing a negative relationship between conservatism and creative accomplishment. Conservatism was estimated, as in previous research, from voting patterns. The voting data used here were from the 2016 US Presidential election. The number of patents granted per county in the United States…

Characteristics of a Cognitive Tool That Helps Students Learn Diagnostic Problem Solving

ERIC Educational Resources Information Center

Danielson, Jared A.; Mills, Eric M.; Vermeer, Pamela J.; Preast, Vanessa A.; Young, Karen M.; Christopher, Mary M.; George, Jeanne W.; Wood, R. Darren; Bender, Holly S.

2007-01-01

Three related studies replicated and extended previous work (J.A. Danielson et al. (2003), "Educational Technology Research and Development," 51(3), 63-81) involving the Diagnostic Pathfinder (dP) (previously Problem List Generator [PLG]), a cognitive tool for learning diagnostic problem solving. In studies 1 and 2, groups of 126 and 113…

Computing the scatter component of mammographic images.

PubMed

Highnam, R P; Brady, J M; Shepstone, B J

1994-01-01

The authors build upon a technical report (Tech. Report OUEL 2009/93, Engng. Sci., Oxford Uni., Oxford, UK, 1993) in which they proposed a model of the mammographic imaging process for which scattered radiation is a key degrading factor. Here, the authors propose a way of estimating the scatter component of the signal at any pixel within a mammographic image, and they use this estimate for model-based image enhancement. The first step is to extend the authors' previous model to divide breast tissue into "interesting" (fibrous/glandular/cancerous) tissue and fat. The scatter model is then based on the idea that the amount of scattered radiation reaching a point is related to the energy imparted to the surrounding neighbourhood. This complex relationship is approximated using published empirical data, and it varies with the size of the breast being imaged. The approximation is further complicated by needing to take account of extra-focal radiation and breast edge effects. The approximation takes the form of a weighting mask which is convolved with the total signal (primary and scatter) to give a value which is input to a "scatter function", approximated using three reference cases, and which returns a scatter estimate. Given a scatter estimate, the more important primary component can be calculated and used to create an image recognizable by a radiologist. The images resulting from this process are clearly enhanced, and model verification tests based on an estimate of the thickness of interesting tissue present proved to be very successful. A good scatter model opens the was for further processing to remove the effects of other degrading factors, such as beam hardening.

Long-term effects of the extended wear of senofilcon A silicone hydrogel contact lenses on ocular tissues.

PubMed

Guillon, Michel; Maïssa, Cécile

2010-12-01

The objective of the investigation was to show that, because of their overall properties, Acuvue® Oasys™ with Hydraclear™ Plus brand (senofilcon A) silicone hydrogel contact lenses achieve excellent ocular tissue tolerance during long-term extended wear. The investigation was a 2-year, prospective, extended wear investigation of senofilcon A silicone hydrogel contact lenses worn for up to 6 nights without removal. The 2-year results compared with the subjects' baseline ocular statuses on entering the study revealed: The quantification of the effects on the ocular tissues of 2 years of extended wear of senofilcon A, by mainly previously successful daily soft contact lens wearers, found an excellent biocompatibility. The results support the hypothesis that senofilcon A contact lenses, when worn on a 6-night/7-day extended wear regimen, maintain excellent long-term ocular tissue tolerance. Copyright © 2010 American Optometric Association. Published by Elsevier Inc. All rights reserved.

The impact of alternate weekly collections on waste arisings.

PubMed

Williams, I D; Cole, C

2013-02-15

Residual waste is commonly collected separately from recyclable and organic materials. Different forms of collection and disposal are used internationally since regional or municipal authorities have to adapt to their own circumstances. Many authorities have adopted an alternate weekly collection (AWC) of residual waste and recyclables to force/encourage householders to recycle; however, the degree to which they achieve waste reduction has yet to be reliably quantified. This study reports on how the introduction of AWCs affects household waste arisings. The paper evaluates single and dual stream collection methods and compares their performance with the previous system. Household waste collection trials were conducted between March and June 2009 in England (Lichfield). The trials examined changes to frequency of collection, type of container issued, amounts of sorting required of residents, household participation and productivity levels. A survey of households was completed before any changes were implemented. The quantity of recyclates collected was examined for 2008/2009 and 2009/2010. The study showed that the AWC scheme positively impacted on recycling rates and household behaviour, with no adverse impacts on public participation, household waste arisings or the local environment. No public health problems were reported. Both trials saw an increase in the quantities of recyclates collected per household during the trial period compared to the same period of time in the previous year. The dual stream performed better than the single stream, collecting an average of 5.94 kg/hh/week compared to an average of 5.63 kg/hh/week. The single stream system showed a greater increase in the weight of material collected (0.53 kg/hh/week vs. 0.48 kg/hh/week). Participation and set-out rates showed an increase during the trial period. The single stream option (comingled materials in one container) outperformed the dual stream service. The reduction in costs and improved productivity were the principal reasons used for extending the trial and making changes to the district's waste collections. The study clearly demonstrates the benefits of local authorities and universities collaborating and identifies practical logistical and operational issues that need to be anticipated. Copyright © 2012 Elsevier B.V. All rights reserved.

Variable laterality of corticospinal tract axons that regenerate after spinal cord injury as a result of PTEN deletion or knock-down

PubMed Central

Willenberg, Rafer; Zukor, Katherine; Liu, Kai; He, Zhigang; Steward, Oswald

2016-01-01

Corticospinal tract (CST) axons from one hemisphere normally extend and terminate predominantly in the contralateral spinal cord. We previously showed that deleting PTEN in the sensorimotor cortex enables CST axons to regenerate after spinal cord injury and that some regenerating axons extend along the “wrong” side. Here, we characterize the degree of specificity of regrowth in terms of laterality. PTEN was selectively deleted via cortical AAV-Cre injections in neonatal PTEN-floxed mice. As adults, mice received dorsal hemisection injuries at T12 or complete crush injuries at T9. CST axons from one hemisphere were traced by unilateral BDA injections in PTEN-deleted mice with spinal cord injury and in non-injured PTEN-floxed mice that had not received AAV-Cre. In non-injured mice, 97.9 ± 0.7% of BDA-labeled axons in white matter and 88.5 ± 1.0% of BDA-labeled axons in grey matter were contralateral to the cortex of origin. In contrast, laterality of CST axons that extended past a lesion due to PTEN deletion varied across animals. In some cases, regenerated axons extended predominantly on the ipsilateral side, in other cases, axons extended predominantly contralaterally, and in others, axons were similar in numbers on both sides. Similar results were seen in analyses of cases from previous studies using shRNA-mediated PTEN knock-down. These results indicate that CST axons that extend past a lesion due to PTEN deletion or knock-down do not maintain the contralateral rule of the non-injured CST, highlighting one aspect for how resultant circuitry from regenerating axons may differ from that of the uninjured CST. PMID:26878190

Practical Aspects of Adolescent Satanism: A Response to Wynkoop.

ERIC Educational Resources Information Center

Moriarty, Anthony

1993-01-01

Responds to previous article by Wynkoop critiquing Moriarty's article of adolescent satanism. Notes that author's (Moriarty) previous article addresses satanism from perspective of differential diagnoses and that Wynkoop's critique cites number of improvements that author believes strengthens original article. Notes that some of Wynkoop's points…

Biofeedback and Electrodermal Self-Regulation in Psychopathy

ERIC Educational Resources Information Center

Steinberg, Earl P.; Schwartz, Gary E.

1976-01-01

Data replicate and extend research on differences in physiological patterning between psychopaths and control subjects and provide new information on patterning with instructions and learned specificity with biofeedback. (Author/RK)

Negative relationships between population density and metabolic rates are not general.

PubMed

Yashchenko, Varvara; Fossen, Erlend Ignacio; Kielland, Øystein Nordeide; Einum, Sigurd

2016-07-01

Population density has recently been suggested to be an important factor influencing metabolic rates and to represent an important 'third axis' explaining variation beyond that explained by body mass and temperature. In situations where population density influences food consumption, the immediate effect on metabolism acting through specific dynamic action (SDA), and downregulation due to fasting over longer periods, is well understood. However, according to a recent review, previous studies suggest a more general effect of population density per se, even in the absence of such effects. It has been hypothesized that this results from animals performing anticipatory responses (i.e. reduced activity) to expected declines in food availability. Here, we test the generality of this finding by measuring density effects on metabolic rates in 10 clones from two different species of the zooplankton Daphnia (Daphnia pulex Leydig and D. magna Straus). Using fluorescence-based respirometry, we obtain high-precision measures of metabolism. We also identify additional studies on this topic that were not included in the previous review, compare the results and evaluate the potential for measurement bias in all previous studies. We demonstrate significant variation in mass-specific metabolism among clones within both species. However, we find no evidence for a negative relationship between population density and mass-specific metabolism. The previously reported pattern also disappeared when we extended the set of studies analysed. We discuss potential reasons for the discrepancy among studies, including two main sources of potential bias (microbial respiration and declining oxygen consumption due to reduced oxygen availability). Only one of the previous studies gives sufficient information to conclude the absence of such biases, and consistent with our results, no effect of density on metabolism was found. We conclude that population density per se does not have a general effect on mass-specific metabolic rate. © 2016 The Authors. Journal of Animal Ecology © 2016 British Ecological Society.

Diversity of chimera-like patterns from a model of 2D arrays of neurons with nonlocal coupling

NASA Astrophysics Data System (ADS)

Tian, Chang-Hai; Zhang, Xi-Yun; Wang, Zhen-Hua; Liu, Zong-Hua

2017-06-01

Chimera states have been studied in 1D arrays, and a variety of different chimera states have been found using different models. Research has recently been extended to 2D arrays but only to phase models of them. Here, we extend it to a nonphase model of 2D arrays of neurons and focus on the influence of nonlocal coupling. Using extensive numerical simulations, we find, surprisingly, that this system can show most types of previously observed chimera states, in contrast to previous models, where only one or a few types of chimera states can be observed in each model. We also find that this model can show some special chimera-like patterns such as gridding and multicolumn patterns, which were previously observed only in phase models. Further, we present an effective approach, i.e., removing some of the coupling links, to generate heterogeneous coupling, which results in diverse chimera-like patterns and even induces transformations from one chimera-like pattern to another.

Extending the authority for sickness certification beyond the medical profession: the importance of 'boundary work'.

PubMed

Welsh, Victoria K; Sanders, Tom; Richardson, Jane C; Wynne-Jones, Gwenllian; Jinks, Clare; Mallen, Christian D

2014-05-17

The study aimed to explore the views of general practitioners (GPs), nurses and physiotherapists towards extending the role of sickness certification beyond the medical profession in primary care. Fifteen GPs, seven nurses and six physiotherapists were selected to achieve varied respondent characteristics including sex, geographical location, service duration and post-graduate specialist training. Constant-comparative qualitative analysis of data from 28 semi-structured telephone interviews was undertaken. The majority of respondents supported the extended role concept; however members of each professional group also rejected the notion. Respondents employed four different legitimacy claims to justify their views and define their occupational boundaries in relation to sickness certification practice. Condition-specific legitimacy, the ability to adopt a holistic approach to sickness certification, system efficiency and control-related arguments were used to different degrees by each occupation. Practical suggestions for the extension of the sickness certification role beyond the medical profession are underpinned by the sociological theory of professional identity. Extending the authority to certify sickness absence beyond the medical profession is not simply a matter of addressing practical and organisational obstacles. There is also a need to consider the impact on, and preferences of, the specific occupations and their respective boundary claims. This paper explores the implications of extending the sick certification role beyond general practice. We conclude that the main policy challenge of such a move is to a) persuade GPs to relinquish this role (or to share it with other professions), and b) to understand the 'boundary work' involved.

Extending the authority for sickness certification beyond the medical profession: the importance of ‘boundary work’

PubMed Central

2014-01-01

Background The study aimed to explore the views of general practitioners (GPs), nurses and physiotherapists towards extending the role of sickness certification beyond the medical profession in primary care. Methods Fifteen GPs, seven nurses and six physiotherapists were selected to achieve varied respondent characteristics including sex, geographical location, service duration and post-graduate specialist training. Constant-comparative qualitative analysis of data from 28 semi-structured telephone interviews was undertaken. Results The majority of respondents supported the extended role concept; however members of each professional group also rejected the notion. Respondents employed four different legitimacy claims to justify their views and define their occupational boundaries in relation to sickness certification practice. Condition-specific legitimacy, the ability to adopt a holistic approach to sickness certification, system efficiency and control-related arguments were used to different degrees by each occupation. Practical suggestions for the extension of the sickness certification role beyond the medical profession are underpinned by the sociological theory of professional identity. Conclusions Extending the authority to certify sickness absence beyond the medical profession is not simply a matter of addressing practical and organisational obstacles. There is also a need to consider the impact on, and preferences of, the specific occupations and their respective boundary claims. This paper explores the implications of extending the sick certification role beyond general practice. We conclude that the main policy challenge of such a move is to a) persuade GPs to relinquish this role (or to share it with other professions), and b) to understand the ‘boundary work’ involved. PMID:24884678

Signal Processing Studies of a Simulated Laser Doppler Velocimetry-Based Acoustic Sensor

DTIC Science & Technology

1990-10-17

investigated using spectral correlation methods. Results indicate that it may be possible to extend demonstrated LDV-based acoustic sensor sensitivities using higher order processing techniques. (Author)

Modeling healthcare authorization and claim submissions using the openEHR dual-model approach

PubMed Central

2011-01-01

Background The TISS standard is a set of mandatory forms and electronic messages for healthcare authorization and claim submissions among healthcare plans and providers in Brazil. It is not based on formal models as the new generation of health informatics standards suggests. The objective of this paper is to model the TISS in terms of the openEHR archetype-based approach and integrate it into a patient-centered EHR architecture. Methods Three approaches were adopted to model TISS. In the first approach, a set of archetypes was designed using ENTRY subclasses. In the second one, a set of archetypes was designed using exclusively ADMIN_ENTRY and CLUSTERs as their root classes. In the third approach, the openEHR ADMIN_ENTRY is extended with classes designed for authorization and claim submissions, and an ISM_TRANSITION attribute is added to the COMPOSITION class. Another set of archetypes was designed based on this model. For all three approaches, templates were designed to represent the TISS forms. Results The archetypes based on the openEHR RM (Reference Model) can represent all TISS data structures. The extended model adds subclasses and an attribute to the COMPOSITION class to represent information on authorization and claim submissions. The archetypes based on all three approaches have similar structures, although rooted in different classes. The extended openEHR RM model is more semantically aligned with the concepts involved in a claim submission, but may disrupt interoperability with other systems and the current tools must be adapted to deal with it. Conclusions Modeling the TISS standard by means of the openEHR approach makes it aligned with ISO recommendations and provides a solid foundation on which the TISS can evolve. Although there are few administrative archetypes available, the openEHR RM is expressive enough to represent the TISS standard. This paper focuses on the TISS but its results may be extended to other billing processes. A complete communication architecture to simulate the exchange of TISS data between systems according to the openEHR approach still needs to be designed and implemented. PMID:21992670

18 CFR 366.6 - Previously authorized activities.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Previously authorized activities. 366.6 Section 366.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... POWER ACT AND NATURAL GAS ACT BOOKS AND RECORDS Definitions and Provisions Under PUHCA 2005, the Federal...

18 CFR 366.6 - Previously authorized activities.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Previously authorized activities. 366.6 Section 366.6 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... POWER ACT AND NATURAL GAS ACT BOOKS AND RECORDS Definitions and Provisions Under PUHCA 2005, the Federal...

Improved detection following Neuro-Eye Therapy in patients with post-geniculate brain damage.

PubMed

Sahraie, Arash; Macleod, Mary-Joan; Trevethan, Ceri T; Robson, Siân E; Olson, John A; Callaghan, Paula; Yip, Brigitte

2010-09-01

Damage to the optic radiation or the occipital cortex results in loss of vision in the contralateral visual field, termed partial cortical blindness or hemianopia. Previously, we have demonstrated that stimulation in the field defect using visual stimuli with optimal properties for blindsight detection can lead to increases in visual sensitivity within the blind field of a group of patients. The present study was aimed to extend the previous work by investigating the effect of positive feedback on recovery of visual sensitivity. Patients' abilities for detection of a range of spatial frequencies within their field defect were determined using a temporal two-alternative forced-choice technique, before and after a period of visual training (n = 4). Patients underwent Neuro-Eye Therapy which involved detection of temporally modulated spatial grating patches at specific retinal locations within their field defect. Three patients showed improved detection ability following visual training. Based on our previous studies, we had hypothesised that should the occipital brain lesion extend anteriorly to the thalamus, little recovery would be expected. Here, we describe one such case who showed no improvements after extensive training. The present study provides further evidence that recovery (a) can be gradual and may require a large number of training sessions (b) can be accelerated using positive feedback and (c) may be less likely to take place if the occipital damage extends anteriorly to the thalamus.

Providing for consideration of the bill (H.R. 2553) to amend the Internal Revenue Code of 1986 to extend the funding and expenditure authority of the Airport and Airway Trust Fund, to amend title 49, United States Code, to extend the airport improvement program, and for other purposes.

THOMAS, 112th Congress

Rep. Webster, Daniel [R-FL-8

2011-07-19

House - 07/20/2011 On agreeing to the resolution Agreed to by recorded vote: 242 - 178 (Roll no. 609). (All Actions) Tracker: This bill has the status Agreed to in HouseHere are the steps for Status of Legislation:

Using neighborhood cohesiveness to infer interactions between protein domains.

PubMed

Segura, Joan; Sorzano, C O S; Cuenca-Alba, Jesus; Aloy, Patrick; Carazo, J M

2015-08-01

In recent years, large-scale studies have been undertaken to describe, at least partially, protein-protein interaction maps, or interactomes, for a number of relevant organisms, including human. However, current interactomes provide a somehow limited picture of the molecular details involving protein interactions, mostly because essential experimental information, especially structural data, is lacking. Indeed, the gap between structural and interactomics information is enlarging and thus, for most interactions, key experimental information is missing. We elaborate on the observation that many interactions between proteins involve a pair of their constituent domains and, thus, the knowledge of how protein domains interact adds very significant information to any interactomic analysis. In this work, we describe a novel use of the neighborhood cohesiveness property to infer interactions between protein domains given a protein interaction network. We have shown that some clustering coefficients can be extended to measure a degree of cohesiveness between two sets of nodes within a network. Specifically, we used the meet/min coefficient to measure the proportion of interacting nodes between two sets of nodes and the fraction of common neighbors. This approach extends previous works where homolog coefficients were first defined around network nodes and later around edges. The proposed approach substantially increases both the number of predicted domain-domain interactions as well as its accuracy as compared with current methods. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

First lunar occultation results from the 2.4 m Thai national telescope equipped with ULTRASPEC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richichi, A.; Irawati, P.; Soonthornthum, B.

2014-11-01

The recently inaugurated 2.4 m Thai National Telescope (TNT) is equipped with, among other instruments, the ULTRASPEC low-noise, frame-transfer EMCCD camera. At the end of its first official observing season, we report on the use of this facility to record high time resolution imaging using small detector subarrays with a sampling as fast as several 10{sup 2} Hz. In particular, we have recorded lunar occultations of several stars that represent the first contribution to this area of research made from Southeast Asia with a telescope of this class. Among the results, we discuss an accurate measurement of α Cnc, whichmore » has been reported previously as a suspected close binary. Attempts by several authors to resolve this star have so far met with a lack of unambiguous confirmation. With our observation we are able to place stringent limits on the projected angular separation (<0.''003) and brightness (Δm > 5) of a putative companion. We also present a measurement of the binary HR 7072, which extends considerably the time coverage available for its yet undetermined orbit. We discuss our precise determination of the flux ratio and projected separation in the context of other available data. We conclude by providing an estimate of the performance of ULTRASPEC at TNT for lunar occultation work. This facility can help to extend the lunar occultation technique in a geographical area where no comparable resources were available until now.« less

Numerical preservation of symmetry properties of continuum problems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Caramana, E.J.; Whalen, P.

1997-12-31

The authors investigate the problem of perfectly preserving a symmetry associated naturally with one coordinate system when calculated in a different coordinate system. This allows a much wider range of problems that may be viewed as perturbations of the given symmetry to be investigated. They study the problem of preserving cylindrical symmetry in two-dimensional cartesian geometry and spherical symmetry in two-dimensional cylindrical geometry. They show that this can be achieved by a simple modification of the gradient operator used to compute the force in a staggered grid Lagrangian hydrodynamics algorithm. In the absence of the supposed symmetry they show thatmore » the new operator produces almost no change in the results because it is always close to the original gradient operator. Their technique this results in a subtle manipulation of the spatial truncation error in favor of the assumed symmetry but only to the extent that it is naturally present in the physical situation. This not only extends the range of previous algorithms and the use of new ones for these studies, but for spherical or cylindrical calculations reduces the sensitivity of the results to grid setup with equal angular zoning that has heretofore been necessary with these problems. Although this work is in two-dimensions, it does point the way to solving this problem in three-dimensions. This is particularly important for the ASCI initiative. The manner in which these results can be extended to three-dimensions will be discussed.« less

Double trouble? The effects of sleep deprivation and chronotype on adolescent affect.

PubMed

Dagys, Natasha; McGlinchey, Eleanor L; Talbot, Lisa S; Kaplan, Katherine A; Dahl, Ronald E; Harvey, Allison G

2012-06-01

  Two understudied risk factors that have been linked to emotional difficulties in adolescence are chronotype and sleep deprivation. This study extended past research by using an experimental design to investigate the role of sleep deprivation and chronotype on emotion in adolescents. It was hypothesized that sleep deprivation and an evening chronotype would be associated with decreased positive affect (PA), increased negative affect (NA), and lower positivity ratios.   Forty-seven healthy adolescents (aged 10-15 for girls, 11-16 for boys) participated in a sleep deprivation and a rested condition. A subsample of 24 adolescents was selected on the basis of extreme morningness or eveningness scores (based on outer quartiles of scores on the Children's Morningness-Eveningness Preferences Scale). PA and NA were measured using the Positive and Negative Affect Schedule for Children, and positivity ratios were calculated by dividing PA by NA.   Participants reported less positive affect and lower positivity ratios when sleep deprived, relative to when rested. Evening chronotypes reported less positive affect and lower positivity ratios than morning chronotypes in both rested and sleep deprivation conditions.   These findings extend previous research by suggesting that adolescents are adversely impacted by sleep deprivation, and that an evening chronotype might serve as a useful marker of emotional vulnerability. Early intervention and prevention strategies can focus on improving sleep and on using chronotherapy principles to reduce eveningness. © 2011 The Authors. Journal of Child Psychology and Psychiatry © 2011 Association for Child and Adolescent Mental Health.

Environmental change mediates mate choice for an extended phenotype, but not for mate quality.

PubMed

Head, Megan L; Fox, Rebecca J; Barber, Iain

2017-01-01

Sexual cues, including extended phenotypes, are expected to be reliable indicators of male genetic quality and/or provide information on parental quality. However, the reliability of these cues may be dependent on stability of the environment, with heterogeneity affecting how selection acts on such traits. Here, we test how environmental change mediates mate choice for multiple sexual traits, including an extended phenotype--the structure of male-built nests - in stickleback fish. First, we manipulated the dissolved oxygen (DO) content of water to create high or low DO environments in which male fish built nests. Then we recorded the mate choice of females encountering these males (and their nests), under either the same or reversed DO conditions. Males in high DO environments built more compact nests than those in low DO conditions and males adjusted their nest structure in response to changing conditions. Female mate choice for extended phenotype (male nests) was environmentally dependent (females chose more compact nests in high DO conditions), while female choice for male phenotype was not (females chose large, vigorous males regardless of DO level). Examining mate choice in this dynamic context suggests that females evaluate the reliability of multiple sexual cues, taking into account environmental heterogeneity. © 2016 The Author(s). Evolution published by Wiley Periodicals, Inc. on behalf of The Society for the Study of Evolution.

Recycling research on spent fluorescent lamps on the basis of extended producer responsibility in China.

PubMed

Peng, Lihong; Wang, Yejun; Chang, Chang-Tang

2014-11-01

Mercury is a physiological toxin released by spent fluorescent lamps (SFLs) and is considered a serious pollutant. As the world's largest producer of fluorescent lamps, China suffers from SFL pollution because of inefficient recycling and management of SFLs. Drawing upon the most successful practices worldwide, this paper suggests the recycling of SFLs on the basis of the extended producer responsibility (EPR) system in China. Manufacturers and importers are the main parties responsible for the take-back, recycling, and disposal ofSFLs in the EPR system. In view of the situation in China and to address the objectives of the EPR system, this paper recommends the implementation of a third-party take-back mode for small- and medium-scale enterprises and of a takeback mode for large enterprises to be carried out by original equipment manufacturers. This paper suggests an extended responsibility fund to finance and support the SFL recycling system and discusses in detail the different recycling network systems and fund flows of the two take-back modes. By conducting a case study, the authors determine that the subsidy rate for SFLs that a recycling company can obtain from the extended responsibility fund for recycling and disposing of lamps can be set at $1.35/kg. The authors also predict the levy level that fluorescent lamp manufacturers must submit.

Enhancing Geoscience Research Discovery Through the Semantic Web

NASA Astrophysics Data System (ADS)

Rowan, Linda R.; Gross, M. Benjamin; Mayernik, Matthew; Khan, Huda; Boler, Frances; Maull, Keith; Stott, Don; Williams, Steve; Corson-Rikert, Jon; Johns, Erica M.; Daniels, Michael; Krafft, Dean B.; Meertens, Charles

2016-04-01

UNAVCO, UCAR, and Cornell University are working together to leverage semantic web technologies to enable discovery of people, datasets, publications and other research products, as well as the connections between them. The EarthCollab project, a U.S. National Science Foundation EarthCube Building Block, is enhancing an existing open-source semantic web application, VIVO, to enhance connectivity across distributed networks of researchers and resources related to the following two geoscience-based communities: (1) the Bering Sea Project, an interdisciplinary field program whose data archive is hosted by NCAR's Earth Observing Laboratory (EOL), and (2) UNAVCO, a geodetic facility and consortium that supports diverse research projects informed by geodesy. People, publications, datasets and grant information have been mapped to an extended version of the VIVO-ISF ontology and ingested into VIVO's database. Much of the VIVO ontology was built for the life sciences, so we have added some components of existing geoscience-based ontologies and a few terms from a local ontology that we created. The UNAVCO VIVO instance, connect.unavco.org, utilizes persistent identifiers whenever possible; for example using ORCIDs for people, publication DOIs, data DOIs and unique NSF grant numbers. Data is ingested using a custom set of scripts that include the ability to perform basic automated and curated disambiguation. VIVO can display a page for every object ingested, including connections to other objects in the VIVO database. A dataset page, for example, includes the dataset type, time interval, DOI, related publications, and authors. The dataset type field provides a connection to all other datasets of the same type. The author's page shows, among other information, related datasets and co-authors. Information previously spread across several unconnected databases is now stored in a single location. In addition to VIVO's default display, the new database can be queried using SPARQL, a query language for semantic data. EarthCollab is extending the VIVO web application. One such extension is the ability to cross-link separate VIVO instances across institutions, allowing local display of externally curated information. For example, Cornell's VIVO faculty pages will display UNAVCO's dataset information and UNAVCO's VIVO will display Cornell faculty member contact and position information. About half of UNAVCO's membership is international and we hope to connect our data to institutions in other countries with a similar approach. Additional extensions, including enhanced geospatial capabilities, will be developed based on task-centered usability testing.

Distributed Leadership in Secondary Schools in England: The Impact on the Role of the Headteacher and Other Issues

ERIC Educational Resources Information Center

Arrowsmith, Trevor

2007-01-01

Distributed leadership (DL) is an emerging form of power distribution in schools which extends authority and influence to groups or individuals in a way which is at least partly contrary to hierarchical arrangements. In this article, the author presents the findings of his study that aimed to answer two questions: (1) What do headteachers do to…

77 FR 31591 - Secretarial Authorization for a Member of the Department of the Navy to Serve on the Board of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

... Department of the Navy to Serve on the Board of Directors, Navy-Marine Corps Relief Society AGENCY... Directors of the Navy-Marine Corps Relief Society. Authorization to serve on the Board of Directors has been... Relief Society. Participation of the above official in the activities of the Society will not extend to...

The US Army and Future Security Force Assistance Operations

DTIC Science & Technology

2013-04-01

havens. It addresses the recent evolution of SFA doctrine, guidance and authorities, and the role of interagency cooperation related to the future...safe havens. It addresses the recent evolution of SFA doctrine, guidance and authorities, and the role of interagency cooperation related to the...organizations at all levels. 5 SFA extends well beyond military-to-military training and conceptually addresses security as a system of

Cryptic extended brood care in the facultatively eusocial sweat bee Megalopta genalis.

PubMed

Quiñones, A E; Wcislo, W T

As a result of different brood cell provisioning strategies, nest-making insects may differ in the extent to which adults regularly provide extended parental care to their brood beyond nest defense. Mass-provisioning species cache the entire food supply needed for larval development prior to the oviposition and typically seal the brood cell. It is usually assumed that there is no regular contact between the adult(s) and brood. Here, we show that the bee, Megalopta genalis , expresses a form of cryptic brood care, which would not be observed during normal development. Following experimental injections of different provisioning materials into brood cells, foundresses reopened manipulated cells and the brood were aborted in some cases, implying that the foundresses assessed conditions within the cells. In aborted cells, foundresses sometimes laid a second egg after first removing dead larvae, previously stored pollen and contaminants. Our results show that hygienic brood care can be cryptic and hence may be more widespread than previously believed, lending support to the hypothesis that extended parental care is a preadaptation toward eusociality.

Public Health and Increased Tobacco Regulation

Cancer.gov

NCI’s Dr. Robert Croyle discusses the Food and Drug Administration’s release of a rule that extends its regulatory authority over tobacco products to include cigars, e-cigarettes, hookah tobacco, and others.

19 CFR 10.231 - Applicability.

Code of Federal Regulations, 2014 CFR

2014-04-01

... Partnership Act (CBTPA), amended section 213(b) of the Caribbean Basin Economic Recovery Act (the CBERA, 19 U.S.C. 2701-2707) to authorize the President to extend additional trade benefits to countries that...

The Effects of Fading a Strategic Self-Monitoring Intervention on Students' Academic Engagement, Accuracy, and Productivity

ERIC Educational Resources Information Center

Rock, Marcia L.; Thead, Beth K.

2007-01-01

In this study, using a single-case multiple-treatment reversal (A-B-A-B-C) research design, we replicated and extended previous strategic self-monitoring research by teaching five students, with and without disabilities, to use ACT-REACT to increase their academic engagement, productivity, and accuracy across new and previously learned math…

The Relative Influence of Formal Learning Opportunities versus Indicators of Professional Community on Changes in Science Teaching in Urban Schools

ERIC Educational Resources Information Center

McGee, Steven

2016-01-01

Previous research has shown that professional communities have the potential to be a powerful lever for continuous improvement in school settings. This research seeks to extend previous research by investigating the indicators of professional community that influence science teaching practice. This study took place in a network of urban…

Examining the Efficacy of Self-Regulated Strategy Development for Students with Emotional or Behavioral Disorders: A Meta-Analysis

ERIC Educational Resources Information Center

Losinski, Mickey; Cuenca-Carlino, Yojanna; Zablocki, Mark; Teagarden, James

2014-01-01

Two previous reviews have indicated that self-regulated strategy instruction (SRSD) is an evidence-based practice that can improve the writing skills of students with emotional and behavioral disorders. The purpose of this meta-analysis is to extend the findings and analytic methods of previous reviews by examining published studies regarding…

Technology-Aided Verbal Instructions to Help Persons with Mild or Moderate Alzheimer's Disease Perform Daily Activities

ERIC Educational Resources Information Center

Lancioni, Giulio E.; Singh, Nirbhay N.; O'Reilly, Mark F.; Sigafoos, Jeff; Tatulli, Emanuela; Rigante, Valeria; Zonno, Nadia; Perilli, Viviana; Pinto, Katia; Minervini, Mauro G.

2010-01-01

These two studies extended previous research on the use of verbal instructions and support technology for helping persons with mild or moderate Alzheimer's disease perform daily activities. Study I included seven participants who were to carry out one of two previously targeted activities (i.e., either coffee preparation or table setting). Study…

Validation of the Self-Beliefs Related to Social Anxiety Scale

PubMed Central

Moulds, Michelle L.; Rapee, Ronald M.

2014-01-01

The importance of self-beliefs in prominent models of social phobia has led to the development of measures that tap this cognitive construct. The Self-Beliefs Related to Social Anxiety (SBSA) Scale is one such measure and taps the three maladaptive belief types proposed in Clark and Wells’s model of social phobia. This study aimed to replicate and extend previous research on the psychometric properties of the SBSA. Replicating previous research, in an (undiagnosed) undergraduate sample (n = 235), the SBSA was found to have a correlated three-factor structure using confirmatory factor analyses, and the SBSA and its subscales demonstrated good internal consistency and test–retest reliability. The SBSA and its subscales also had unique relationships with social anxiety and depression, the majority of which replicated previous research. Extending previous research, the SBSA and its subscales showed good incremental validity in the undergraduate sample and good discriminative validity using the undergraduate sample and a sample of individuals with social phobia (n = 33). The SBSA’s strong theoretical basis and the findings of this study suggest that the SBSA is an ideal research and clinical tool to assess the cognitions characteristic of social phobia. PMID:23575344

Activation of extended red emission photoluminescence in carbon solids by exposure to atomic hydrogen and UV radiation

NASA Technical Reports Server (NTRS)

Furton, Douglas G.; Witt, Adolf N.

1993-01-01

We report on new laboratory results which relate directly to the observation of strongly enhanced extended red emission (ERE) by interstellar dust in H2 photodissociation zones. The ERE has been attributed to photoluminescence by hydrogenated amorphous carbon (HAC). We are demonstrating that exposure to thermally dissociated atomic hydrogen will restore the photoluminescence efficiency of previously annealed HAC. Also, pure amorphous carbon (AC), not previously photoluminescent, can be induced to photoluminesce by exposure to atomic hydrogen. This conversion of AC into HAC is greatly enhanced by the presence of UV irradiation. The presence of dense, warm atomic hydrogen and a strong UV radiation field are characteristic environmental properties of H2 dissociation zones. Our results lend strong support to the HAC photoluminescence explanation for ERE.

Tracing evolutionary relicts of positive selection on eight malaria-related immune genes in mammals.

PubMed

Huang, Bing-Hong; Liao, Pei-Chun

2015-07-01

Plasmodium-induced malaria widely infects primates and other mammals. Multiple past studies have revealed that positive selection could be the main evolutionary force triggering the genetic diversity of anti-malaria resistance-associated genes in human or primates. However, researchers focused most of their attention on the infra-generic and intra-specific genome evolution rather than analyzing the complete evolutionary history of mammals. Here we extend previous research by testing the evolutionary link of natural selection on eight candidate genes associated with malaria resistance in mammals. Three of the eight genes were detected to be affected by recombination, including TNF-α, iNOS and DARC. Positive selection was detected in the rest five immunogenes multiple times in different ancestral lineages of extant species throughout the mammalian evolution. Signals of positive selection were exposed in four malaria-related immunogenes in primates: CCL2, IL-10, HO1 and CD36. However, selection signals of G6PD have only been detected in non-primate eutherians. Significantly higher evolutionary rates and more radical amino acid replacement were also detected in primate CD36, suggesting its functional divergence from other eutherians. Prevalent positive selection throughout the evolutionary trajectory of mammalian malaria-related genes supports the arms race evolutionary hypothesis of host genetic response of mammalian immunogenes to infectious pathogens. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy.

PubMed

Pang, Ka Ming; Castanotto, Daniela; Li, Haitang; Scherer, Lisa; Rossi, John J

2018-01-09

Gene therapy by engineering patient's own blood cells to confer HIV resistance can potentially lead to a functional cure for AIDS. Toward this goal, we have previously developed an anti-HIV lentivirus vector that deploys a combination of shRNA, ribozyme and RNA decoy. To further improve this therapeutic vector against viral escape, we sought an additional reagent to target HIV integrase. Here, we report the development of a new strategy for selection and expression of aptamer for gene therapy. We developed a SELEX protocol (multi-tag SELEX) for selecting RNA aptamers against proteins with low solubility or stability, such as integrase. More importantly, we expressed these aptamers in vivo by incorporating them in the terminal loop of shRNAs. This novel strategy allowed efficient expression of the shRNA-aptamer fusions that targeted RNAs and proteins simultaneously. Expressed shRNA-aptamer fusions targeting HIV integrase or reverse transcriptase inhibited HIV replication in cell cultures. Viral inhibition was further enhanced by combining an anti-integrase aptamer with an anti-HIV Tat-Rev shRNA. This construct exhibited efficacy comparable to that of integrase inhibitor Raltegravir. Our strategy for the selection and expression of RNA aptamers can potentially extend to other gene therapy applications. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

What does the geography of parthenogenesis teach us about sex?

PubMed

Tilquin, Anaïs; Kokko, Hanna

2016-10-19

Theory predicts that sexual reproduction is difficult to maintain if asexuality is an option, yet sex is very common. To understand why, it is important to pay attention to repeatably occurring conditions that favour transitions to, or persistence of, asexuality. Geographic parthenogenesis is a term that has been applied to describe a large variety of patterns where sexual and related asexual forms differ in their geographic distribution. Often asexuality is stated to occur in a habitat that is, in some sense, marginal, but the interpretation differs across studies: parthenogens might not only predominate near the margin of the sexuals' distribution, but might also extend far beyond the sexual range; they may be disproportionately found in newly colonizable areas (e.g. areas previously glaciated), or in habitats where abiotic selection pressures are relatively stronger than biotic ones (e.g. cold, dry). Here, we review the various patterns proposed in the literature, the hypotheses put forward to explain them, and the assumptions they rely on. Surprisingly, few mathematical models consider geographic parthenogenesis as their focal question, but all models for the evolution of sex could be evaluated in this framework if the (often ecological) causal factors vary predictably with geography. We also recommend broadening the taxa studied beyond the traditional favourites.This article is part of the themed issue 'Weird sex: the underappreciated diversity of sexual reproduction'. © 2016 The Author(s).

Fluctuating hydrogen-bond networks govern anomalous electron transfer kinetics in a blue copper protein.

PubMed

Kretchmer, Joshua S; Boekelheide, Nicholas; Warren, Jeffrey J; Winkler, Jay R; Gray, Harry B; Miller, Thomas F

2018-06-12

We combine experimental and computational methods to address the anomalous kinetics of long-range electron transfer (ET) in mutants of Pseudomonas aeruginosa azurin. ET rates and driving forces for wild type (WT) and three N47X mutants (X = L, S, and D) of Ru(2,2'-bipyridine) 2 (imidazole)(His83) azurin are reported. An enhanced ET rate for the N47L mutant suggests either an increase of the donor-acceptor (DA) electronic coupling or a decrease in the reorganization energy for the reaction. The underlying atomistic features are investigated using a recently developed nonadiabatic molecular dynamics method to simulate ET in each of the azurin mutants, revealing unexpected aspects of DA electronic coupling. In particular, WT azurin and all studied mutants exhibit more DA compression during ET (>2 Å) than previously recognized. Moreover, it is found that DA compression involves an extended network of hydrogen bonds, the fluctuations of which gate the ET reaction, such that DA compression is facilitated by transiently rupturing hydrogen bonds. It is found that the N47L mutant intrinsically disrupts this hydrogen-bond network, enabling particularly facile DA compression. This work, which reveals the surprisingly fluctional nature of ET in azurin, suggests that hydrogen-bond networks can modulate the efficiency of long-range biological ET. Copyright © 2018 the Author(s). Published by PNAS.

BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis.

PubMed

Bagger, Frederik Otzen; Sasivarevic, Damir; Sohi, Sina Hadi; Laursen, Linea Gøricke; Pundhir, Sachin; Sønderby, Casper Kaae; Winther, Ole; Rapin, Nicolas; Porse, Bo T

2016-01-04

Research on human and murine haematopoiesis has resulted in a vast number of gene-expression data sets that can potentially answer questions regarding normal and aberrant blood formation. To researchers and clinicians with limited bioinformatics experience, these data have remained available, yet largely inaccessible. Current databases provide information about gene-expression but fail to answer key questions regarding co-regulation, genetic programs or effect on patient survival. To address these shortcomings, we present BloodSpot (www.bloodspot.eu), which includes and greatly extends our previously released database HemaExplorer, a database of gene expression profiles from FACS sorted healthy and malignant haematopoietic cells. A revised interactive interface simultaneously provides a plot of gene expression along with a Kaplan-Meier analysis and a hierarchical tree depicting the relationship between different cell types in the database. The database now includes 23 high-quality curated data sets relevant to normal and malignant blood formation and, in addition, we have assembled and built a unique integrated data set, BloodPool. Bloodpool contains more than 2000 samples assembled from six independent studies on acute myeloid leukemia. Furthermore, we have devised a robust sample integration procedure that allows for sensitive comparison of user-supplied patient samples in a well-defined haematopoietic cellular space. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Sex linkage, sex-specific selection, and the role of recombination in the evolution of sexually dimorphic gene expression.

PubMed

Connallon, Tim; Clark, Andrew G

2010-12-01

Sex-biased genes--genes that are differentially expressed within males and females--are nonrandomly distributed across animal genomes, with sex chromosomes and autosomes often carrying markedly different concentrations of male- and female-biased genes. These linkage patterns are often gene- and lineage-dependent, differing between functional genetic categories and between species. Although sex-specific selection is often hypothesized to shape the evolution of sex-linked and autosomal gene content, population genetics theory has yet to account for many of the gene- and lineage-specific idiosyncrasies emerging from the empirical literature. With the goal of improving the connection between evolutionary theory and a rapidly growing body of genome-wide empirical studies, we extend previous population genetics theory of sex-specific selection by developing and analyzing a biologically informed model that incorporates sex linkage, pleiotropy, recombination, and epistasis, factors that are likely to vary between genes and between species. Our results demonstrate that sex-specific selection and sex-specific recombination rates can generate, and are compatible with, the gene- and species-specific linkage patterns reported in the genomics literature. The theory suggests that sexual selection may strongly influence the architectures of animal genomes, as well as the chromosomal distribution of fixed substitutions underlying sexually dimorphic traits. © 2010 The Author(s). Evolution© 2010 The Society for the Study of Evolution.

Illustrations from the Wellcome Library William Winstanley’s Pestilential Poesies in The Christians Refuge: Or Heavenly Antidotes Against the Plague in this Time of Generall Contagion to Which is Added the Charitable Physician (1665)

PubMed Central

MILLER, KATHLEEN

2011-01-01

During the Great Plague of London (1665), William Winstanley veered from his better known roles as arbiter of success and failure in his works of biography or as a comic author under the pseudonym Poor Robin, and instead engaged with his reading audience as a plague writer in the rare book The Christians Refuge: Or Heavenly Antidotes Against the Plague in this Time of Generall Contagion to Which is Added the Charitable Physician (1665). From its extensive paratexts, including a table of mortality statistics and woodcut of king death, to its temporal and providential interpretation of the disease between the covers of a single text, The Christians Refuge is a compendium of contemporary understanding of plague. This article addresses The Christians Refuge as an expression of London’s print marketplace in a moment of transformation precipitated by the epidemic. The author considers the paratextual elements in The Christians Refuge that engage with the presiding norms in plague writing and publishing in 1665 and also explores how Winstanley’s authorship is expressed in the work. Winstanley has long been seen as a biographer or as a humour writer; attributing The Christians Refuge extends and challenges previous perceptions of his work. PMID:21461312

ConsPred: a rule-based (re-)annotation framework for prokaryotic genomes.

PubMed

Weinmaier, Thomas; Platzer, Alexander; Frank, Jeroen; Hellinger, Hans-Jörg; Tischler, Patrick; Rattei, Thomas

2016-11-01

The rapidly growing number of available prokaryotic genome sequences requires fully automated and high-quality software solutions for their initial and re-annotation. Here we present ConsPred, a prokaryotic genome annotation framework that performs intrinsic gene predictions, homology searches, predictions of non-coding genes as well as CRISPR repeats and integrates all evidence into a consensus annotation. ConsPred achieves comprehensive, high-quality annotations based on rules and priorities, similar to decision-making in manual curation and avoids conflicting predictions. Parameters controlling the annotation process are configurable by the user. ConsPred has been used in the institutions of the authors for longer than 5 years and can easily be extended and adapted to specific needs. The ConsPred algorithm for producing a consensus from the varying scores of multiple gene prediction programs approaches manual curation in accuracy. Its rule-based approach for choosing final predictions avoids overriding previous manual curations. ConsPred is implemented in Java, Perl and Shell and is freely available under the Creative Commons license as a stand-alone in-house pipeline or as an Amazon Machine Image for cloud computing, see https://sourceforge.net/projects/conspred/. thomas.rattei@univie.ac.atSupplementary information: Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Search for annihilating dark matter in the Sun with 3 years of IceCube data: IceCube Collaboration

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aartsen, M. G.; Ackermann, M.; Adams, J.

© 2017, The Author(s). We present results from an analysis looking for dark matter annihilation in the Sun with the IceCube neutrino telescope. Gravitationally trapped dark matter in the Sun’s core can annihilate into Standard Model particles making the Sun a source of GeV neutrinos. IceCube is able to detect neutrinos with energies > 100 GeV while its low-energy infill array DeepCore extends this to > 10 GeV. This analysis uses data gathered in the austral winters between May 2011 and May 2014, corresponding to 532 days of livetime when the Sun, being below the horizon, is a source of up-going neutrinomore » events, easiest to discriminate against the dominant background of atmospheric muons. The sensitivity is a factor of two to four better than previous searches due to additional statistics and improved analysis methods involving better background rejection and reconstructions. The resultant upper limits on the spin-dependent dark matter-proton scattering cross section reach down to 1.46 × 10 - 5  pb for a dark matter particle of mass 500 GeV annihilating exclusively into τ + τ - particles. These are currently the most stringent limits on the spin-dependent dark matter-proton scattering cross section for WIMP masses above 50 GeV.« less

Bayesian hierarchical models for cost-effectiveness analyses that use data from cluster randomized trials.

PubMed

Grieve, Richard; Nixon, Richard; Thompson, Simon G

2010-01-01

Cost-effectiveness analyses (CEA) may be undertaken alongside cluster randomized trials (CRTs) where randomization is at the level of the cluster (for example, the hospital or primary care provider) rather than the individual. Costs (and outcomes) within clusters may be correlated so that the assumption made by standard bivariate regression models, that observations are independent, is incorrect. This study develops a flexible modeling framework to acknowledge the clustering in CEA that use CRTs. The authors extend previous Bayesian bivariate models for CEA of multicenter trials to recognize the specific form of clustering in CRTs. They develop new Bayesian hierarchical models (BHMs) that allow mean costs and outcomes, and also variances, to differ across clusters. They illustrate how each model can be applied using data from a large (1732 cases, 70 primary care providers) CRT evaluating alternative interventions for reducing postnatal depression. The analyses compare cost-effectiveness estimates from BHMs with standard bivariate regression models that ignore the data hierarchy. The BHMs show high levels of cost heterogeneity across clusters (intracluster correlation coefficient, 0.17). Compared with standard regression models, the BHMs yield substantially increased uncertainty surrounding the cost-effectiveness estimates, and altered point estimates. The authors conclude that ignoring clustering can lead to incorrect inferences. The BHMs that they present offer a flexible modeling framework that can be applied more generally to CEA that use CRTs.

The Oldest Actinopterygian Highlights the Cryptic Early History of the Hyperdiverse Ray-Finned Fishes.

PubMed

Lu, Jing; Giles, Sam; Friedman, Matt; den Blaauwen, Jan L; Zhu, Min

2016-06-20

Osteichthyans comprise two divisions, each containing over 32,000 living species [1]: Sarcopterygii (lobe-finned fishes and tetrapods) and Actinopterygii (ray-finned fishes). Recent discoveries from China highlight the morphological disparity of early sarcopterygians and extend their origin into the late Silurian [2-4]. By contrast, the oldest unambiguous actinopterygians are roughly 30 million years younger, leaving a long temporal gap populated by fragments and rare body fossils of controversial phylogenetic placement [5-10]. Here we reinvestigate the enigmatic osteichthyan Meemannia from the Early Devonian (∼415 million years ago) of China, previously identified as an exceptionally primitive lobe-finned fish [3, 7, 11, 12]. Meemannia combines "cosmine"-like tissues taken as evidence of sarcopterygian affinity with actinopterygian-like skull roof and braincase geometry, including endoskeletal enclosure of the spiracle and a lateral cranial canal. We report comparable histological structures in undoubted ray-finned fishes and conclude that they are general osteichthyan features. Phylogenetic analysis places Meemannia as an early-diverging ray-finned fish, resolving it as the sister lineage of Cheirolepis [13] plus all younger actinopterygians. This brings the first appearance of ray-fins more in line with that of lobe-fins and fills a conspicuous faunal gap in the otherwise diverse late Silurian-earliest Devonian vertebrate faunas of the South China Block [4]. Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.

The effects of telemedicine on racial and ethnic disparities in access to acute stroke care.

PubMed

Lyerly, Michael J; Wu, Tzu-Ching; Mullen, Michael T; Albright, Karen C; Wolff, Catherine; Boehme, Amelia K; Branas, Charles C; Grotta, James C; Savitz, Sean I; Carr, Brendan G

2016-03-01

Racial and ethnic disparities have been previously reported in acute stroke care. We sought to determine the effect of telemedicine (TM) on access to acute stroke care for racial and ethnic minorities in the state of Texas. Data were collected from the US Census Bureau, The Joint Commission and the American Hospital Association. Access for racial and ethnic minorities was determined by summing the population that could reach a primary stroke centre (PSC) or telemedicine spoke within specified time intervals using validated models. TM extended access to stroke expertise by 1.5 million residents. The odds of providing 60-minute access via TM were similar in Blacks and Whites (prevalence odds ratios (POR) 1.000, 95% CI 1.000-1.000), even after adjustment for urbanization (POR 1.000, 95% CI 1.000-1.001). The odds of providing access via TM were also similar for Hispanics and non-Hispanics (POR 1.000, 95% CI 1.000-1.000), even after adjustment for urbanization (POR 1.000, 95% CI 1.000-1.000). We found that telemedicine increased access to acute stroke care for 1.5 million Texans. While racial and ethnic disparities exist in other components of stroke care, we did not find evidence of disparities in access to the acute stroke expertise afforded by telemedicine. © The Author(s) 2015.

Towards a framework for the elicitation of dilemmas.

PubMed

Burger, Marc J C

2008-08-01

This paper covers the main findings of the doctoral research that was concerned with seeking to extend aspects of dilemma theory. In professional practice, the Trompenaars Hampden-Turner Dilemma Reconciliation Process(TM) is a vehicle delivering dilemma theory in application. It informs a manager or leader on how to explore the dilemmas they face, how to reconcile the tensions that result, and how to structure the action steps for implementing the reconciled solutions. This vehicle forms the professional practice of the author who seeks to bring more rigor to consulting practice and thereby also contribute to theory development in the domain. The critical review of dilemma theory reveals that previous authors are inconsistent and variously invalid in their use of the terms 'dilemma theory,' 'dilemma methodology,' 'dilemma process,' 'dilemma reconciliation,' etc., and therefore an attempt is made to resolve these inconsistencies by considering whether 'dilemmaism' at the meta-level might be positioned as a new paradigm of inquiry for (management) research that embodies ontological, epistemological, and methodical premises that frame an approach to the resolution of real world business problems in (multi) disciplinary; (multi) functional and (multi) cultural business environments. This research offers contributions to knowledge, professional practice and theory development from the exploration of the SPID model as a way to make the elicitation of dilemmas more rigorous and structured and in the broader context of exploring 'dilemmaism' as a new paradigm of inquiry.

Suppression of natural killer cell cytotoxicity in postpartum women: time course and potential mechanisms.

PubMed

Groer, Maureen W; El-Badri, Nagwa; Djeu, Julie; Williams, S Nicole; Kane, Bradley; Szekeres, Karoly

2014-07-01

Little is known about the recovery of the immune system from normal pregnancy and whether the postpartum period is a uniquely adapted immune state. This report extends previous observations from our group of decreased natural killer (NK) cell cytotoxicity in the postpartum period. NK cytotoxicity was measured from 1 week through 9 months postpartum. In addition, NK cytotoxicity was assayed in the presence or absence of pooled plasmas collected from either postpartum or nonpostpartum women. Samples of cells were stained for inhibitory receptors and analyzed by flow cytometry. NK cytotoxicity remained decreased in postpartum women compared to controls through the first 6 postpartum months, returned to normal levels by 9 months, and remained normal at 12 months. NK cytotoxicity during the first 6 months was further inhibited by the addition of pooled plasma to NK cultures from postpartum women, but the addition of pooled plasma from the control group did not affect that group's NK cultures. There were differences in inhibitory receptor staining between the two groups, with decreased CD158a and CD158b and increased NKG2A expression on postpartum NK cells during the first 3 postpartum months. These data suggest that NK cytotoxicity postpartum inhibition lasts 6 months and is influenced by unidentified postpartum plasma components. The effect may also involve receptors on NK cells. © The Author(s) 2013.