Objective Comparison of Commercially Available Breast Implant Devices.

PubMed

Henderson, Peter W; Nash, David; Laskowski, Marta; Grant, Robert T

2015-10-01

Breast implants are frequently used for both cosmetic breast augmentation and breast reconstruction after mastectomy. Three companies currently offer FDA-approved breast implants (Allergan, Mentor, and Sientra), but their product offerings-including permanent breast implants, breast tissue expanders, sizers, and post-operative warranty-can be difficult to compare because of brand names and company-specific jargon. The ability to have a brand-agnostic understanding of all available options is important for both the surgical trainee as well as the surgeon in clinical practice. After a brief review of the history of breast implant devices, this review utilizes a unique conceptual framework based on variables such as fill material, shape, relative dimensions, and surface coating to facilitate a better understanding of the similarities and differences between the different company's offerings. Specifically, we identify which types of devices are offered by all three companies, those that are offered by only one company, those that have very limited product offerings, and those combinations that are not available at all. Finally, clinical implications are drawn from this framework that can be used by both cosmetic and reconstructive surgeons to counsel patients about all available options. Importantly, this project is entirely independent of any company's funding, support, or input. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Marketing in the Special Library Environment.

ERIC Educational Resources Information Center

Powers, Janet E.

1995-01-01

Special libraries developed in response to a need for quick access to specific information. Integrated marketing in special libraries focuses the library toward strategic planning and offers the opportunity to develop more effective library services. (Author/AEF)

Managerial Support for Dual-Career Relocation Dilemmas.

ERIC Educational Resources Information Center

Eby, Lillian T.; Douthitt, Shane S.; Perrin, Towers; Noble, Carrie L.; Atchley, Kate P.; Ladd, Robert T.

2002-01-01

Managers (n=143) completed a simulation exercise involving requests for employment assistance for the spouses of relocating employees. About one-third authorized specific actions. However, managers offered more extensive assistance to the spouses of female employees. (Contains 60 references.) (SK)

Struggling for Equality/Struggling for Hierarchy: Gender Dynamics in an English as an Additional Language Classroom for Adolescent Vietnamese Refugees

ERIC Educational Resources Information Center

Robbins, Kristin

2004-01-01

In this article the author explores how the specific gender dynamics among newly arrived Vietnamese children influence classroom behavior in unanticipated ways. By focusing on specific ethnic experiences and data, analyzing similarities and differences, and offering other major findings on gender and power dynamics, she adds to the literature on…

38 CFR 21.4272 - Collegiate course measurement.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the school offering the degree under authority specifically conferred by a State education agency, and... accredited school must certify either: (i) That credits have been accepted on transfer at full value without... (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Administration of Educational Assistance Programs...

Embracing Silence and the Emptiness between Unspoken Words

ERIC Educational Resources Information Center

VanSlyke-Briggs, Kjersti

2014-01-01

This article examines the use of silence as a constructive teaching tool in the classroom rather than as a punitive measure. The author offers suggestions for the inclusion of silence to benefit students specifically in a literature high school classroom.

CRISPR/Cas9-loxP-Mediated Gene Editing as a Novel Site-Specific Genetic Manipulation Tool.

PubMed

Yang, Fayu; Liu, Changbao; Chen, Ding; Tu, Mengjun; Xie, Haihua; Sun, Huihui; Ge, Xianglian; Tang, Lianchao; Li, Jin; Zheng, Jiayong; Song, Zongming; Qu, Jia; Gu, Feng

2017-06-16

Cre-loxP, as one of the site-specific genetic manipulation tools, offers a method to study the spatial and temporal regulation of gene expression/inactivation in order to decipher gene function. CRISPR/Cas9-mediated targeted genome engineering technologies are sparking a new revolution in biological research. Whether the traditional site-specific genetic manipulation tool and CRISPR/Cas9 could be combined to create a novel genetic tool for highly specific gene editing is not clear. Here, we successfully generated a CRISPR/Cas9-loxP system to perform gene editing in human cells, providing the proof of principle that these two technologies can be used together for the first time. We also showed that distinct non-homologous end-joining (NHEJ) patterns from CRISPR/Cas9-mediated gene editing of the targeting sequence locates at the level of plasmids (episomal) and chromosomes. Specially, the CRISPR/Cas9-mediated NHEJ pattern in the nuclear genome favors deletions (64%-68% at the human AAVS1 locus versus 4%-28% plasmid DNA). CRISPR/Cas9-loxP, a novel site-specific genetic manipulation tool, offers a platform for the dissection of gene function and molecular insights into DNA-repair pathways. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

Electric Company Critique: Can Great Be Good Enough?

ERIC Educational Resources Information Center

Roser, Nancy L.

1974-01-01

Offers specific examples of instructional goals and their corresponding teaching techniques used in "The Electric Company" that do not substantiate the definition of reading as communication between author and reader, the effective reader being one who brings meaning to the printed word. (TO)

Post-Secondary Education and Rural-Urban Migration

ERIC Educational Resources Information Center

Synge, J.

1974-01-01

This study examined education and career plans of Scottish rural youth who entered post-secondary education in order to determine the extent to which the educational system offers rural youth not only specific training but only entry to the urban labour market. (Author/RK)

Services, architectures, and protocols for space data systems

NASA Technical Reports Server (NTRS)

Helgert, Hermann J.

1991-01-01

The author presents a comprehensive discussion of three major aspects of the work of the Consultative Committee for Space Data Systems (CCSDS), a worldwide cooperative effort of national space agencies. The author examines the CCSDS space data communications network concept on which the data communications facilities of future advanced orbiting systems will be based. He derives the specifications of an open communications architecture as a reference model for the development of services and protocols that support the transfer of information over space data communications networks. Detailed specifications of the communication services and information transfer protocols that have reached a high degree of maturity and stability are offered. The author also includes a complete list of currently available CCSDS standards and supporting documentation.

Influences on the Career Development of Gay Men.

ERIC Educational Resources Information Center

Prince, Jeffrey P.

1995-01-01

Relates selected concepts from the general literature of gay and lesbian psychology to the career development of gay men. Specific concerns related to sexual identity development, the management of stigma, and psychological adjustment are reviewed, and suggestions are offered both to practitioners and researchers. (Author)

Wellness among African American Counselors

ERIC Educational Resources Information Center

Day-Vines, Norma L.; Holcomb-McCoy, Cheryl

2007-01-01

Although there are various definitions of wellness, few conceptual definitions have addressed the contextual dimensions of wellness relative to African American counselors. The authors present an overview of generic models of wellness, discuss factors that both inhibit and promote wellness, offer some culture-specific models of wellness, and…

Teaching about Domestic Violence: Strategies for Empowerment.

ERIC Educational Resources Information Center

Gardner, Saundra

1993-01-01

Offers the author's experiences in teaching a college-level domestic violence sociology course, presenting specific strategies and a description of the syllabus. The course presents a feminist analysis of domestic violence and examines how the patriarchal structure and ideology of society create and perpetuate violence. (SLD)

31 CFR 515.565 - Educational activities.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Educational activities. 515.565..., Authorizations, and Statements of Licensing Policy § 515.565 Educational activities. (a) Specific institutional... structured educational program in Cuba as part of a course offered at the licensed institution, provided the...

48 CFR 28.202 - Acceptability of corporate sureties.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Acceptability of corporate... Acceptability of corporate sureties. (a)(1) Corporate sureties offered for bonds furnished with contracts... (1) new approved corporate surety companies and (2) the termination of the authority of any specific...

77 FR 12635 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-01

.... Securities Offering. Series 86 Research Analyst--Analysis..... From $160 to $175. Series 87 Research Analyst... Order Processing Assistant Representatives, Research Analysts and Operations Professionals, respectively... examination.\\7\\ \\6\\ PROCTOR is a computer system that is specifically designed for the administration and...

Use Level and Encounters: Important Variables of Perceived Crowding Among Nonspecialized Recreationists.

ERIC Educational Resources Information Center

Hammitt, William E.; And Others

1984-01-01

Use level, visual encounters, crowding expectations, and feelings were examined by regression techniques to explain perceived crowding among innertube floaters. Degree of user specialization and specificity for any given activity and place is offered as an explanation for the discrepancy from previous findings. (Author/DF)

Higher Goals in Mathematics Education

ERIC Educational Resources Information Center

Kolar-Begovic, Zdenka, Ed.; Kolar-Šuper, Ružica, Ed.; Ðurdevic Babic, Ivana, Ed.

2015-01-01

This monograph offers an overview of the current research work carried out in Croatia and the surrounding countries, and specifically an interesting insight in teaching and learning issues in these countries. The authors discuss the need of the general population for becoming good problem-solvers in society of today, which is characterised by…

Schools Fail to Promote Student Self-Development: The Case for Deliberate Psychological Education

ERIC Educational Resources Information Center

Vriend, John; Dyer, Wayne W.

1976-01-01

The emphasis here is on the need for affective education rather than on specific 'How-to's.' The concerned educator is the intended audience, and powerful arguments for including DPE in the school are offered as ammunition for persuading educational decision-makers. (Author/BD)

Supporting Classroom Transitions between Daily Routines: Strategies and Tips

ERIC Educational Resources Information Center

Banerjee, Rashida; Horn, Eva

2013-01-01

The purpose of this article is to provide tools for preschool professionals to plan for transitions between daily routines, to identify challenging transitions during the day, and to offer strategies to support transitions in classrooms to prevent challenging behaviors from occurring due to frequent changes. Specifically, the authors answer three…

A Media Mix Test of Paid Radio Advertising for Armed Services Recruitment. Volume II.

DTIC Science & Technology

1976-05-01

This was a test of the effectiveness of paid radio recruiting advertising . The four active military services (Army, Navy, Air Force, Marine Corps...service, awareness and knowledge of specific programs and benefits offered by individual services and awareness of armed forces advertising . (Author)

A Media MIX Test of Paid Radio Advertising for Armed Services Recruitment. Volume 3. Addendum.

DTIC Science & Technology

1976-07-01

This was a test of the effectiveness of paid radio recruiting advertising . The four active military services (Army, Navy, Air Force, Marine Corps...service, awareness and knowledge of specific programs and benefits offered by individual services and awareness of armed forces advertising . (Author)

The Importance of Knowing Ourselves.

ERIC Educational Resources Information Center

Farquhar, Robin H.

This speech focuses on the protection of institutional autonomy in higher education. The speaker opens by offering some of his own basic beliefs. The balance of the paper considers three key issues central to institutional autonomy. The first issue involves specific threats to autonomy: the socio-cultural mistrust of authority and institutions,…

Considerations in Counseling the Retiring Career Officer for Reemployment

ERIC Educational Resources Information Center

Schlenoff, David

1977-01-01

In this article, the unique characteristics of the retiring career officer are discussed, and specific problems encountered by counselors assisting the career officer in his or her transition from the military to civilian work environment are noted. Suggestions are offered concerning counseling such persons for reemployment. (Author)

Selected Issues in Mathematics Education.

ERIC Educational Resources Information Center

Lindquist, Mary Montgomery, Ed.

This document examines specifically relevant issues and offers useful guidance in making decisions for elementary and secondary school mathematics education in the 1980's. The expertise of 19 authors is reflected in 14 chapters that provide an overview of mathematics today and recommendations for the future. The individual chapters are titled: (1)…

Rediscovering Black Women's Literature. Review Essay [Book Review].

ERIC Educational Resources Information Center

George, Hermon, Jr.

1992-01-01

These volumes offer a blend of genres, authors, and purposes. Specific portraits are provided for each volume in chronological order. The central historical and educational values are in the view that the books give of the world of petit-bourgeois African-American women at the turn of the century. (SLD)

Into The 1990's: Environmental Education in the USA.

ERIC Educational Resources Information Center

Disinger, John F.; Floyd, Donald W.

1990-01-01

Activities in environmental education in the United States during the 1980s are summarized, in terms of audiences involved--formal (school), college/university, and nonformal. Discussion focuses on specific programs and materials, in summary fashion. Trends are noted, and speculative projections into the 1990s are offered. (36 references) (Author)

Antecedents of Substance Use among Mexican American School-Age Children.

ERIC Educational Resources Information Center

Zapata, Jesse T.; Katims, David S.

1994-01-01

This study examines the association of demographic, psychological, and environmental characteristics of a sample of low socioeconomic status, Mexican American students and their reported use of nine substances. Results indicate that a specific combination of variables predicted both minor and major substances used. The authors offer suggestions…

Complete Copyright for K-12 Librarians and Educators

ERIC Educational Resources Information Center

Russell, Carrie

2012-01-01

School librarians and educators have specific copyright questions that are often glossed over in larger books on the subject. Now, thanks to best-selling copyright authority Carrie Russell, there's a resource just for them, offering clear guidance for providing materials to students while carefully observing copyright law. Using whimsical…

A Learning Framework for the Small Business Environment

ERIC Educational Resources Information Center

Kelliher, Felicity; Henderson, Joan Bernadette

2006-01-01

Purpose: The aim of this article is to offer insight into the factors affecting individual and organisational learning in a small business; specifically the identification of the learning relationships that are unique to the small business environment. Design/methodology/approach: The authors apply Crossan et al.'s (1997, 1999) Organisational…

Training in quality and safety: the current landscape.

PubMed

Karasick, Andrew S; Nash, David B

2015-01-01

The current US health care environment requires and encourages the development and implementation of training programs focusing on quality improvement and patient safety. This article offers a new resource that details the basic characteristics of such physician-inclusive training programs. Specifically, program type, objectives, eligibility, cost, training length, and modality are aggregated and displayed to provide health care professionals with a new tool to facilitate individual education in the field of quality improvement and patient safety. © The Author(s) 2014.

Beyond bankable dollars: establishing a business case for improving health care.

PubMed

Bailit, Michael; Dyer, Mary Beth

2004-09-01

To address widespread deficiencies in the quality of health care, the authors argue that health care organizations need to be able to make a "business case" for improving quality--a compelling rationale for financial investment in quality improvement programs. The authors' framework for such a business case is organized around three broad areas: direct financial considerations, strategic considerations, and internal organizational considerations. Within these categories, they offer a total of 10 specific business case arguments, with examples, for investing in quality improvement.

The Impact of Language Factors on Learner Achievement in Science

ERIC Educational Resources Information Center

Prinsloo, C. H.; Rogers, S. C.; Harvey, J. C.

2018-01-01

South African learner achievement remains poor, despite large investment in schooling over the last two decades. Literature and research findings offer no single explanation or solution. In this article, the authors explored the relative contribution of specific language factors such as the role of home- and school-language equivalence, cultural…

Future Schools: Blending Face-to-Face and Online Learning

ERIC Educational Resources Information Center

Schorr, Jonathan; McGriff, Deborah

2012-01-01

"Hybrid schools" are schools that combine "face-to-face" education in a specific place with online instruction. In this article, the authors describe school models which offer a vision for what deeply integrated technology can mean for children's education, for the way schools are structured, and for the promise of greater…

Vocational Rehabilitation Day-Care Services for a Drug-Dependent Population

ERIC Educational Resources Information Center

Weiner, Harvey; And Others

1977-01-01

The philosophy, history, and operations of the Vocational Opportunities Center (VOC) are described. The VOC is offered as a model of employability service to a specific client group and part of a more comprehensive multimodality drug program. Presented at the National Drug Abuse Conference, San Francisco, May 5-9, 1977. (Author)

The Past as More than Prologue: A Call for Historical Research

ERIC Educational Resources Information Center

Horsford, Sonya Douglass; D'Amico, Diana

2015-01-01

Purpose: The purpose of this paper is to argue that historical research methods offer an innovative and powerful way to examine, frame, explain, and disrupt the study of contemporary issues in educational leadership. More specifically, the authors examine how historical methodology might recast some of the questions educational leadership…

Exploring "Whakaaro": A Way of Responsive Thinking in Maori Research

ERIC Educational Resources Information Center

Mika, Carl; Southey, Kim

2018-01-01

The experience of researching as a Maori student within academia will often raise questions about how and whether the student's research privileges Maori world views and articulates culturally specific epistemologies. This study offers some theorising, from the perspectives of a Maori doctoral student and her Maori supervisor (the authors of this…

"Waiting for Superman" to Save Black People: Racial Representation and the Official Antiracism of Neoliberal School Reform

ERIC Educational Resources Information Center

Dumas, Michael J.

2013-01-01

The author argues that the documentary, "Waiting for Superman," effectively employs bodies and texts in ways that reproduce hegemonic constructions of race, and more specifically, offers an image and imagination of black engagement in education that reinforces neoliberal-multicultural narratives about black disinterest in, and…

A Rhetorical Analysis of the Self in an Organization: The Production and Reception of Discourse in a Bank.

ERIC Educational Resources Information Center

Roberts, Joy S.

1999-01-01

Describes briefly the author's research (contributing to scholarship on successful language practices in organizations) examining the conflicts, and specifically the discursive methods of solving these conflicts, faced by individuals within an organization as they negotiate competing demands. Offers a new tool (called Bracketing, Ranking, and…

Infertility and Crisis: Self-Discovery and Healing through Poetry Writing.

ERIC Educational Resources Information Center

Barney, Anne

1992-01-01

Offers a personal narrative on how the author's own poetry helped her cope with the crisis of infertility, serving as a tool for self-discovery and healing. Suggests that specific advantages of poetry writing within the context of psychotherapy include problem solving; expression of feelings; insight; couple communication; and individual and…

Identifying domestic and international sex-trafficking victims during human service provision.

PubMed

Macy, Rebecca J; Graham, Laurie M

2012-04-01

Children, youth, and adults of both genders are sex trafficked into and throughout the United States every day. Regrettably, little attention has been given to how human service providers might identify the sex-trafficking victims they are likely to encounter. To address this knowledge gap, the authors review 20 documents with the aim of detecting and synthesizing service identification recommendations in the scientific literature, government reports, and documents produced by organizations working with sex-trafficking victims. The review shows consensus regarding identification recommendations, including (a) trafficking indicators, (b) victim interaction strategies, (c) immediate response strategies, and (d) child-specific information. The review also shows consensus regarding screening questions that are important for service providers to use in identifying sex-trafficking victims. These questions relate to the victims' safety, employment, living environment, and travel and immigration status in addition to specific questions used with children and youth. The review results offer human service providers a preliminary set of screening strategies and questions that can be used to identify sex-trafficking victims in the context of human services. Building on the review findings, the authors offer policy and research recommendations.

[Results of a study of the diagnostic qualities of brucellosis and tularemic antigenic erythrocytic diagnostica].

PubMed

Tsybin, B P; Taran, I F; Tinker, A I

1975-09-01

The authors elaborated methods of preparation of brucella and tularemia antigenic erythrocytic diagnostic agents which were characterized as highly specific, specific and stable preparations in mass examination of humans and animals at various stages of the vaccinal and infectous processes. The simplicity of obtaining specific antigens intended for the sensitization of formalinized erythrocytes and stability of the results of results of reproduction of the methods of preparation of the antigenic erythrocytic diagnostic agents offered a possibility of recommending the mentioned methods of industrial preparation of the diagnostic agents.

Putting food on the public health table: Making food security relevant to regional health authorities.

PubMed

Rideout, Karen; Seed, Barbara; Ostry, Aleck

2006-01-01

Food security is emerging as an increasingly important public health issue. The purpose of this paper is to describe a conceptual model and five classes of food security indicators for regional health authorities (RHAs): direct, indirect, consequence, process, and supra-regional. The model was developed after a review of the food security literature and interviews with British Columbia community nutritionists and public health officials. We offer this conceptual model as a practical tool to help RHAs develop a comprehensive framework and use specific indicators, in conjunction with public health nutritionists and other community stakeholders. We recommend using all five classes of indicator together to ensure a complete assessment of the full breadth of food security. This model will be useful for Canadian health authorities wishing to take a holistic community-based approach to public health nutrition to develop more effective policies and programs to maximize food security. The model and indicators offer a rational process that could be useful for collaborative multi-stakeholder initiatives to improve food security.

49 CFR 173.51 - Authorization to offer and transport explosives.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 2 2011-10-01 2011-10-01 false Authorization to offer and transport explosives... Class 1 § 173.51 Authorization to offer and transport explosives. (a) Unless otherwise provided in this subpart, no person may offer for transportation or transport an explosive, unless it has been tested and...

49 CFR 173.51 - Authorization to offer and transport explosives.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 2 2010-10-01 2010-10-01 false Authorization to offer and transport explosives... Class 1 § 173.51 Authorization to offer and transport explosives. (a) Unless otherwise provided in this subpart, no person may offer for transportation or transport an explosive, unless it has been tested and...

Use of MCAT Data in Admissions. A Guide for Medical School Admissions Officers and Faculty.

ERIC Educational Resources Information Center

Mitchell, Karen J.

A description of the standardized, multiple-choice Medical College Admission Test (MCAT) and how to use it is offered. Medical school admissions officers medical educators, college faculty members, and practicing physicians are active participants in selecting content, drafting test specifications, and authoring questions for the exam. The MCAT is…

Describing, Analysing and Judging Language Codes in Cinematic Discourse

ERIC Educational Resources Information Center

Richardson, Kay; Queen, Robin

2012-01-01

In this short commentary piece, the authors stand back from many of the specific details in the seven papers which constitute the special issue, and offer some observations which attempt to identify and assess points of similarity and difference amongst them, under a number of different general headings. To the extent that the "sociolinguistics of…

Evolving Systems of Care with Total Clinical Outcomes Management

ERIC Educational Resources Information Center

Lyons, John S.; Epstein, Richard A.; Jordan, Neil

2010-01-01

The current article proposes that further specification of the system of care concept is required. Based on the assertions that the system of care concept (a) refers to an ideal as opposed to an observable phenomenon, and (b) is engaged in offering transformational experiences, the authors propose that the system of care definition must be…

Grade School Philosophy: How Come and Where To?

ERIC Educational Resources Information Center

Lipman, Matthew

The inclusion of philosophy as part of the elementary school curriculum is discussed in this paper. A definite trend toward specifically including ethics and logic offers a starting point for a philosophy course as part of the general curriculum or as a separate course of study. The author begins by presenting a general analysis of the recent…

Visual Thinking Strategies: Teachers' Reflections on Closely Reading Complex Visual Texts within the Disciplines

ERIC Educational Resources Information Center

Cappello, Marva; Walker, Nancy T.

2016-01-01

The authors offer a new perspective on close reading that uses a range of multimodal texts to capitalize on the visual nature of contemporary society and to support literacy within the academic disciplines. Specifically, a qualitative study explored teachers' perspectives on the use of Visual Thinking Strategies (VTS), a practice borrowed from…

Proposals for Standardizing and Improving the Policy of Adding Points on the Entrance Exam

ERIC Educational Resources Information Center

Yuhong, Deng

2013-01-01

This article reviews policies for adding points on the College Entrance Examination. It analyzes the rationales and specific implementation strategies of various policies for adding points on the entrance exam, as well as their advantages and pitfalls. Based on these observations and analysis, the author also offers policy recommendations on the…

The Emotionally-Handicapped Child: Altering Home, School, and Social Environments as the Key to Prevention and Cure.

ERIC Educational Resources Information Center

Jones, Vern

The author examines the causes of behavioral disorders that stem from conditions existing in the home, school, and society, and offers specific recommendations for institutional changes which would reduce the number of behaviorally disordered children. Factors noted to be significantly related to emotional difficulties include divorce; the…

Investigating the Role of Domain General Mechanisms in the Acquisition of Domain Specific Expertise

ERIC Educational Resources Information Center

Kaufman, Scott Barry

2007-01-01

The expert performance approach championed by Ericsson et al. provides a scientific way forward for research on giftedness, and offers exciting new ways to further one's understanding of the determinants of high ability within a particular domain of expertise. While the methods the authors use are commendable and are likely to further one's…

Teaching Math to Young Children. Educator's Practice Guide. What Works Clearinghouse. NCEE 2014-4005

ERIC Educational Resources Information Center

Frye, Douglas; Baroody, Arthur J.; Burchinal, Margaret; Carver, Sharon M.; Jordan, Nancy C.; McDowell, Judy

2013-01-01

The goal of this practice guide is to offer educators specific, evidence-based recommendations that address the challenge of teaching early math to children ages 3 to 6. The guide provides practical, clear information on critical topics related to teaching early math and is based on the best available evidence as judged by the authors. The guide…

Segmented Assimilation Theory and the Life Model: An Integrated Approach to Understanding Immigrants and Their Children

ERIC Educational Resources Information Center

Piedra, Lissette M.; Engstrom, David W.

2009-01-01

The life model offers social workers a promising framework to use in assisting immigrant families. However, the complexities of adaptation to a new country may make it difficult for social workers to operate from a purely ecological approach. The authors use segmented assimilation theory to better account for the specificities of the immigrant…

Sorting the Wheat from the Chaff: What Makes for Good Evidence of Effectiveness in the Literature in Gifted Education?

ERIC Educational Resources Information Center

Callahan, Carolyn M.; Moon, Tonya R.

2007-01-01

To provide an overview of the specific components that must be considered when making decisions about research in the field of gifted education, the authors describe and evaluate the three types of evidence--speculative or anecdotal, theoretical, and empirical--commonly offered in the literature of the field. Empirical, or evidence-based, research…

Ethics, Vulnerability, and Speakers of Other Languages: How University IRBs (Do Not) Speak to Research Involving Refugee Participants

ERIC Educational Resources Information Center

Perry, Kristen H.

2011-01-01

In this study, the author analyzes the websites of 32 universities' Institutional Review Boards (IRBs) to explore two specific issues: (a) how individual IRBs define "vulnerable populations," and (b) the guidelines those IRBs offer with respect to participants who may have limited or no English language proficiency. Analysis indicates wide…

Detection of Inter- and Intra-Specific Competition in the Insect Communities of British Trees: A Practical Exercise in Community Ecology.

ERIC Educational Resources Information Center

Putman, R. J.

1984-01-01

Describes an activity (suitable for high school or college) in which the effects of competition in the structuring of ecological communities are examined. The exercise also offers an introduction into species diversity; more advanced classes may be encouraged to seek reasons for differences in insect diversity on different trees. (Author/JN)

Writing Juvenile Stories and Novels: How to Write and Sell Fiction for Young People.

ERIC Educational Resources Information Center

Whitney, Phyllis A.

Phyllis Whitney, author of more than 30 juvenile novels and 20 adult novels, offers specific advice to aspiring writers on how to write, and sell, fiction for young people. Telling a good story, entertaining the reader, is the most important factor in each of the four divisions of children's books. These divisions can be structured roughly…

Specialist Bibliographic Databases

PubMed Central

2016-01-01

Specialist bibliographic databases offer essential online tools for researchers and authors who work on specific subjects and perform comprehensive and systematic syntheses of evidence. This article presents examples of the established specialist databases, which may be of interest to those engaged in multidisciplinary science communication. Access to most specialist databases is through subscription schemes and membership in professional associations. Several aggregators of information and database vendors, such as EBSCOhost and ProQuest, facilitate advanced searches supported by specialist keyword thesauri. Searches of items through specialist databases are complementary to those through multidisciplinary research platforms, such as PubMed, Web of Science, and Google Scholar. Familiarizing with the functional characteristics of biomedical and nonbiomedical bibliographic search tools is mandatory for researchers, authors, editors, and publishers. The database users are offered updates of the indexed journal lists, abstracts, author profiles, and links to other metadata. Editors and publishers may find particularly useful source selection criteria and apply for coverage of their peer-reviewed journals and grey literature sources. These criteria are aimed at accepting relevant sources with established editorial policies and quality controls. PMID:27134485

Specialist Bibliographic Databases.

PubMed

Gasparyan, Armen Yuri; Yessirkepov, Marlen; Voronov, Alexander A; Trukhachev, Vladimir I; Kostyukova, Elena I; Gerasimov, Alexey N; Kitas, George D

2016-05-01

Specialist bibliographic databases offer essential online tools for researchers and authors who work on specific subjects and perform comprehensive and systematic syntheses of evidence. This article presents examples of the established specialist databases, which may be of interest to those engaged in multidisciplinary science communication. Access to most specialist databases is through subscription schemes and membership in professional associations. Several aggregators of information and database vendors, such as EBSCOhost and ProQuest, facilitate advanced searches supported by specialist keyword thesauri. Searches of items through specialist databases are complementary to those through multidisciplinary research platforms, such as PubMed, Web of Science, and Google Scholar. Familiarizing with the functional characteristics of biomedical and nonbiomedical bibliographic search tools is mandatory for researchers, authors, editors, and publishers. The database users are offered updates of the indexed journal lists, abstracts, author profiles, and links to other metadata. Editors and publishers may find particularly useful source selection criteria and apply for coverage of their peer-reviewed journals and grey literature sources. These criteria are aimed at accepting relevant sources with established editorial policies and quality controls.

Psychosocial Interventions in Reducing Cannabis Use in Early Phase Psychosis: A Canadian Survey of Treatments Offered.

PubMed

Aydin, Cristina; Tibbo, Philip G; Ursuliak, Zenovia

2016-06-01

Cannabis use in people with early phase psychosis (EPP) can have a significant impact on long-term outcomes. The purpose of this investigation was to describe current cannabis use treatment practices in English-speaking early intervention services (EISs) in Canada and determine if their services are informed by available evidence. Thirty-five Canadian English-speaking EISs for psychosis were approached to complete a survey through email, facsimile, or online in order to collect information regarding their current cannabis use treatment practices. Data were acquired from 27 of the 35 (78%) programs approached. Only 12% of EISs offered formal services that targeted cannabis use, whereas the majority (63%) of EISs offered informal services for all substance use, not specifically cannabis. In programs with informal services, individual patient psychoeducation (86%) was slightly more common than individual motivational interviewing (MI) (76%) followed by group patient psychoeducation (52%) and information handouts (52%). Thirty-seven percent of EISs offered formal services for substance use, and compared to programs with informal services, more MI, cognitive-behavioural therapy, and family services were offered, with individual treatment modalities more common than groups. No EISs used contingency management, even though it has some preliminary evidence in chronic populations. Evidence-based service implementation barriers included appropriate training and administrative support. While most English-speaking Canadian EIS programs offer individual MI and psychoeducation, which is in line with the available literature, there is room for improvement in cannabis treatment services based on current evidence for both people with EPP and their families. © The Author(s) 2016.

Sex selection for non-medical indications: a survey of current pre-implantation genetic screening practices among U.S. ART clinics.

PubMed

Capelouto, Sarah M; Archer, Sydney R; Morris, Jerrine R; Kawwass, Jennifer F; Hipp, Heather S

2018-03-01

This study aimed to determine the current percentage of United States (U.S.) assisted reproductive technology (ART) clinics offering sex selection via pre-implantation genetic screening (PGS) for non-medical purposes. The authors conducted website review and telephone interview survey of 493 U.S. ART clinics performing in vitro fertilization (IVF) in 2017. Main outcome measures were pre-implantation genetic screening (PGS)/pre-implantation genetic diagnosis (PGD) practices and non-medical sex selection practices including family balancing. Of the 493 ART clinics in the USA, 482 clinics (97.8%) responded to our telephone interview survey. Among all U.S. ART clinics, 91.9% (n = 449) reported offering PGS and/or PGD. Furthermore, 476 clinics responded to survey questions about sex selection practices. Of those ART clinics, 72.7% (n = 346) reported offering sex selection. More specifically among those clinics offering sex selection, 93.6% (n = 324) reported performing sex selection for family balancing, and 81.2% (n = 281) reported performing for elective purposes (patient preference, regardless of rationale for the request). For couples without infertility, 83.5% (n = 289) of clinics offer sex selection for family balancing and 74.6% (n = 258) for non-specific elective reasons. The majority of U.S. ART clinics offer non-medical sex selection, a percentage that has increased substantially since last reported in 2006.

Innovative Approaches in Chronic Disease Management: Health Literacy Solutions and Opportunities for Research Validation.

PubMed

Villaire, Michael; Gonzalez, Diana Peña; Johnson, Kirby L

2017-01-01

This chapter discusses the need for innovative health literacy solutions to combat extensive chronic disease prevalence and costs. The authors explore the intersection of chronic disease management and health literacy. They provide specific examples of successful health literacy interventions for managing several highly prevalent chronic diseases. This is followed by suggestions on pairing research and practice to support effective disease management programs. In addition, the authors discuss strategies for collection and dissemination of knowledge gained from collaborations between researchers and practitioners. They identify current challenges specific to disseminating information from the health literacy field and offer potential solutions. The chapter concludes with a brief look at future directions and organizational opportunities to integrate health literacy practices to address the need for effective chronic disease management.

The Interaction-Activity Connection

NASA Technical Reports Server (NTRS)

Borne, Kirk D.

1996-01-01

A review is presented of the numerous studies that have been undertaken to investigate the likely interaction-activity connection among galaxies. Both observational evidence and theoretical supporting models are reviewed. Some specific examples of "interactive" galaxies from the author's own research are presented: (a) the collision-induced AGN (Active Galactic Nuclei) activity in the radio jet source 3C278; and (b) the collision-induced starburst activity in the spectacular "Cartwheel" ring galaxy. Some comments are offered concerning some of the more promising theoretical investigations that are now taking place. A few words of warning are also offered about the possible misinterpretation of putative collision-induced morphologies among some galaxy samples.

Development of innovative activity of the enterprises of construction branch in the direction of increase in resource-saving and energy efficiency

NASA Astrophysics Data System (ADS)

Papelniuk, Oksana

2017-10-01

The author studies innovative activity of enterprises and carries out the classification of conditions and factors of construction enterprises’ innovative activity, and conducts systematization of specific features of this innovative activity. On the basis of statistical data on structure and dynamics of innovations the author carries out the research with the use of methods of economic-mathematical modelling in order to offer the approach which will allow construction enterprises to define the directions of innovative activity for achievement of a resource-saving and energy efficiency in construction sector.

In Favor of Clear Thinking: Incorporating Moral Rules Into a Wise Cost-Benefit Analysis-Commentary on Bennis, Medin, & Bartels (2010).

PubMed

Bazerman, Max H; D Greene, Joshua

2010-03-01

Bennis, Medin, and Bartels (2010, this issue) have contributed an interesting article on the comparative benefit of moral rules versus cost-benefit analysis (CBA). Many of their specific comments are accurate, useful, and insightful. At the same time, we believe they have misrepresented CBA and have reached a set of conclusions that are misguided and, if adopted wholesale, potentially dangerous. Overall, they offer wise suggestions for making CBA more effective, rather than eliminating CBA as a decision-making tool. © The Author(s) 2010.

Predicting appointment breaking.

PubMed

Bean, A G; Talaga, J

1995-01-01

The goal of physician referral services is to schedule appointments, but if too many patients fail to show up, the value of the service will be compromised. The authors found that appointment breaking can be predicted by the number of days to the scheduled appointment, the doctor's specialty, and the patient's age and gender. They also offer specific suggestions for modifying the marketing mix to reduce the incidence of no-shows.

5 CFR 831.114 - Voluntary early retirement-substantial delayering, reorganization, reduction in force, transfer...

Code of Federal Regulations, 2010 CFR

2010-01-01

... voluntary early retirement authority must be signed by the head of the agency or by a specific designee. (c... to be accepted may be announced to a different group of employees as long as they are covered by the... retirement offer; and (2) Meets the following conditions which are covered in 5 U.S.C. 8336(d)(2): (i) Has...

5 CFR 831.114 - Voluntary early retirement-substantial delayering, reorganization, reduction in force, transfer...

Code of Federal Regulations, 2011 CFR

2011-01-01

... voluntary early retirement authority must be signed by the head of the agency or by a specific designee. (c... to be accepted may be announced to a different group of employees as long as they are covered by the... retirement offer; and (2) Meets the following conditions which are covered in 5 U.S.C. 8336(d)(2): (i) Has...

Selected School Laws and Standards. A Summary Containing Specific School Laws Relating to Area Schools, Standards for Area Community Colleges and Area Vocational Schools.

ERIC Educational Resources Information Center

Iowa State Dept. of Public Instruction, Des Moines. Area Schools and Career Education Branch.

This document provides a selected summary of school laws relating to area schools and standards for area community colleges and vocational schools in Iowa. Area schools are authorized to offer the first two years of college work, pre-professional education, vocational and technical training, inservice training and retraining of workers, programs…

Evidence-based guidelines for the pharmacological treatment of postmenopausal osteoporosis: a consensus document by the Belgian Bone Club

PubMed Central

Body, J.-J.; Bergmann, P.; Boonen, S.; Boutsen, Y.; Devogelaer, J.-P.; Goemaere, S.; Kaufman, J.-M.; Rozenberg, S.

2010-01-01

Several drugs are available for the management of postmenopausal osteoporosis. This may, in daily practice, confuse the clinician. This manuscript offers an evidence-based update of previous treatment guidelines, with a critical assessment of the currently available efficacy data on all new chemical entities which were granted a marketing authorization. Osteoporosis is widely recognized as a major public health concern. The availability of new therapeutic agents makes clinical decision-making in osteoporosis more complex. Nation-specific guidelines are needed to take into consideration the specificities of each and every health care environment. The present manuscript is the result of a National Consensus, based on a systematic review and a critical appraisal of the currently available literature. It offers an evidence-based update of previous treatment guidelines, with the aim of providing clinicians with an unbiased assessment of osteoporosis treatment effect. PMID:20480148

Interrogating discourse: the application of Foucault's methodological discussion to specific inquiry.

PubMed

Fadyl, Joanna K; Nicholls, David A; McPherson, Kathryn M

2013-09-01

Discourse analysis following the work of Michel Foucault has become a valuable methodology in the critical analysis of a broad range of topics relating to health. However, it can be a daunting task, in that there seems to be both a huge number of possible approaches to carrying out this type of project, and an abundance of different, often conflicting, opinions about what counts as 'Foucauldian'. This article takes the position that methodological design should be informed by ongoing discussion and applied as appropriate to a particular area of inquiry. The discussion given offers an interpretation and application of Foucault's methodological principles, integrating a reading of Foucault with applications of his work by other authors, showing how this is then applied to interrogate the practice of vocational rehabilitation. It is intended as a contribution to methodological discussion in this area, offering an interpretation of various methodological elements described by Foucault, alongside specific application of these aspects.

Inpatient Applications of Cognitive-Behavioral Therapy

PubMed Central

STUART, SCOTT; THASE, MICHAEL E.

1994-01-01

The authors review empirical research of the past decade on cognitive-behavioral therapy (CBT) in the treatment of depressed inpatients and offer suggestions for future investigations. CBT appears to offer additive benefits in combination with pharmacotherapy, particularly after the transition from inpatient to outpatient treatment. CBT also holds promise as a primary treatment for inpatients but has not been clearly shown to be as effective as antidepressants. There is as yet no evidence that inpatient CBT is superior to other psychotherapies of comparable intensity or that short-term inpatient CBT has enduring value if not followed by outpatient therapy. Further research is needed to clarify the specific effects of CBT for inpatients and to establish its cost-effectiveness. PMID:22700196

The Index Medicus: Why It Works and When It Doesn't *

PubMed Central

Jackson, Mary F.

1966-01-01

A user study of the Index Medicus done at the Walter Reed Army Medical Center included responses from a group of sixty researchers, clinicians, residents, and interns. An analysis of the questionnaire shows that, while all respondents use the Index Medicus, most use it to search for a specific subject or a specific author reference. Comments received were critical of the delay from the time of journal publication until the appearance of its citation in Index Medicus. Suggestions were offered concerning the type of publication most of the respondents would prefer. PMID:5921472

Diversity in case management modalities: the Summit model.

PubMed

Peterson, G A; Drone, I D; Munetz, M R

1997-06-01

Though ubiquitous in community mental health agencies, case management suffers from a lack of consensus regarding its definition, essential components, and appropriate application. Meaningful comparisons of various case management models await such a consensus. Global assessments of case management must be replaced by empirical studies of specific interventions with respect to the needs of specific populations. The authors describe a highly differentiated and prescriptive system of case management involving the application of more than one model of service delivery. Such a diversified and targeted system offers an opportunity to study the technology of case management in a more meaningful manner.

Guidance on the selection of cohorts for the extended one-generation reproduction toxicity study (OECD test guideline 443).

PubMed

Moore, Nigel P; Beekhuijzen, Manon; Boogaard, Peter J; Foreman, Jennifer E; North, Colin M; Palermo, Christine; Schneider, Steffen; Strauss, Volker; van Ravenzwaay, Bennard; Poole, Alan

2016-10-01

The extended one-generation reproduction toxicity study (EOGRTS; OECD test guideline 433) is a new and technically complex design to evaluate the putative effects of chemicals on fertility and development, including effects upon the developing nervous and immune systems. In addition to offering a more comprehensive assessment of developmental toxicity, the EOGRTS offers important improvements in animal welfare through reduction and refinement in a modular study design. The challenge to the practitioner is to know how the modular aspects of the study should be triggered on the basis of prior knowledge of a particular chemical, or on earlier findings in the EOGRTS itself, requirements of specific regulatory frameworks notwithstanding. The purpose of this document is to offer guidance on science-based triggers for these extended evaluations. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Social contexts of drug offers among American Indian youth and their relationship to substance use: an exploratory study.

PubMed

Kulis, Stephen; Okamoto, Scott K; Rayle, Andrea Dixon; Sen, Soma

2006-01-01

In this exploratory study the authors examined the social contexts of American Indian youths' encounters with drug offers and their relationship to substance use. Using an inventory of drug use-related problem situations developed specifically for American Indian youth, questionnaires were completed by 71 American Indian youth at public middle schools in a Southwest metropolitan area. Regression analyses highlight the importance of situational and relational contexts in understanding substance use among the youth in this sample. Exposure to drug offers through parents, other adults, cousins, friends and other peers was associated with different types of substance use. Exposure through parents was particularly salient in predicting the drug use of female respondents. The study underscores the need for development of culturally grounded prevention programs in schools, reservations, and nonreservation communities. Copyright (c) 2006 APA, all rights reserved.

PHONATION TAKES PRECEDENCE IN DEVELOPMENT AS WELL AS EVOLUTION OF LANGUAGE

PubMed Central

Oller, D. Kimbrough

2014-01-01

Early development of vocalization in humans is characterized by emerging control of phonation, rather than of prosody or supraglottal articulation. This fact offers an opportunity to the authors of the target article to enrich their characterization of the evolution of differential brain mechanisms in human and non-human primates. Phonation, I suggest, is the initial target of human-specific brain changes in sound-making capability upon which language is founded. PMID:25514957

Commercialization of genetic testing services: the FDA, market forces, and biological tarot cards.

PubMed

Malinowski, M J; Blatt, R J R

1997-03-01

Many women fear being diagnosed with breast cancer, and rightfully so. Despite the capabilities of modern medicine, the cumulative lifetime risk of getting the disease has risen to one in eight and, despite decades of research, no cures exist. In this Article, the authors explore the commercialization of so-called breast cancer gene tests, based upon genetic alterations linked to the disease. Although the authors fully address this specific technology, they use what constitutes the seminal case of predictive genetic testing to analyze the adequacy of the existing regulatory framework. The authors conclude that the present regulatory system is inadequate and places a dangerous amount of reliance on primary care physicians. Their conclusion is grounded in the observation that most primary care physicians lack sufficient knowledge about this evolving investigative technology--which is highly subject to misinterpretation, and, though potentially helpful to some "high risk" patients, offers questionable clinical value for the general public. The authors set forth numerous proposals to promote both the quality and clinical value of predictive genetic testing so that it conforms to public health standards and can be properly integrated as a reliable component of medical care in specific situations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Davis, R. S.

The following are specific topics of this paper: 1.There is much creativity in the manner in which Dimensional Generator can be applied to a specific programming task [2]. This paper tells how Dimensional Generator was applied to a reactor-physics task. 2. In this first practical use, Dimensional Generator itself proved not to need change, but a better user interface was found necessary, essentially because the relevance of Dimensional Generator to reactor physics was initially underestimated. It is briefly described. 3. The use of Dimensional Generator helps make reactor-physics source code somewhat simpler. That is explained here with brief examples frommore » BURFEL-PC and WIMSBURF. 4. Most importantly, with the help of Dimensional Generator, all erroneous physical expressions were automatically detected. The errors are detailed here (in spite of the author's embarrassment) because they show clearly, both in theory and in practice, how Dimensional Generator offers quality enhancement of reactor-physics programming. (authors)« less

Industrial bioprocesses: beyond routine applications of established methodologies.

PubMed

Junker, Beth

2010-04-15

The subject matter of manuscripts by industrial authors has primarily focused on elements with perceived commercial or regulatory significance. Once published, this information interacted and ultimately influenced manuscripts from authors of other affiliations, creating the rapid advancements that culminated in the current multi-billion dollar worldwide biotechnology industry. This paper discusses trends in "solely industrial" articles published in the specific journal of Biotechnology and Bioengineering over the past five decades of this journal's lifetime. "Solely industrial" articles were defined as papers in which all the authors were affiliated with industry. Data were gathered concerning "solely industrial" article distribution and frequency, authoring companies, subject classification, and category distribution. Selected articles and their impact were related to current and past technology milestones as well as associated challenges. Suggestions for areas of greater emphasis to influence the number and subject matter of "solely industrial" articles for the journal's sixth decade were offered for consideration.

38 CFR 21.4266 - Approval of courses at a branch campus or extension.

Code of Federal Regulations, 2011 CFR

2011-07-01

... organization; and (iii) Offers courses in education programs leading to a degree, certificate, or other... institution is offering the course may be temporary will not serve to change jurisdictional authority. (3) The... which the course is being taught will not serve to change jurisdictional authority. (Authority: 38 U.S.C...

38 CFR 21.4266 - Approval of courses at a branch campus or extension.

Code of Federal Regulations, 2010 CFR

2010-07-01

... organization; and (iii) Offers courses in education programs leading to a degree, certificate, or other... institution is offering the course may be temporary will not serve to change jurisdictional authority. (3) The... which the course is being taught will not serve to change jurisdictional authority. (Authority: 38 U.S.C...

Black Male Mental Health and the Black Church: Advancing a Collaborative Partnership and Research Agenda.

PubMed

Robinson, Michael A; Jones-Eversley, Sharon; Moore, Sharon E; Ravenell, Joseph; Adedoyin, A Christson

2018-06-01

This article explores the role the Black Church could play in facilitating spiritually sensitive, culturally relevant and gender-specific services to address the mental health and well-being of Black males. The help-seeking behaviors of Black men are examined as the authors offer two theories: the body, mind, spirit, environment, social, transcendent, and health, illness, men, and masculinities that may assist the Black Church in functioning as an effective support networks for healthy Black male mental health. Next, the authors discuss implications for practice, research, and education, and lastly, eight recommendations for Black Church leadership, social workers, and mental health professionals are also discussed.

Some business and tax aspects of clinical practice plans.

PubMed

Mancino, D

1978-10-01

Medical schools throughout the country have developed diverse organizational forms through which their faculty members provide clinical services. In this article the author reviews several of the reasons frequently offered to support involvement of a medical school in a faculty practice plan and suggests many business and tax considerations which should be taken into account by a medical school in developing a plan to meet its objectives. He also reviews many of the considerations involved in establishing and operating specific types of group practice plans. The author concludes that, with conscientious planning and implementation, faculty members can receive professional satisfaction, medical schools can obtain many benefits, and the public will benefit from improved health care.

Prevention of deaths and injuries caused by house fires: survey of local authority smoke alarm policies.

PubMed

Rowland, Diane; Afolabi, Elizabeth; Roberts, Ian

2002-09-01

Despite an increased risk of fire in disadvantaged households, smoke alarm ownership is considerably lower than in the general population. The government currently recommends that local authorities install battery-operated smoke alarms in all public sector properties regardless of tenure. However, the extent to which local authorities comply is currently not known. We conducted a survey of local authorities to establish the extent of their smoke alarm provision to public sector households. A telephone survey of all 405 local authorities within England and Wales was carried out. We obtained responses from 390 (97 per cent) local authorities, 266 of which had responsibility for housing. Over half of all public-sector households are offered smoke alarms by the local authorities. The majority of local authorities offer ionization and/or optical sensor alarm types (78 per cent), with many local authorities providing battery-operated alarms alone (17 per cent) or in combination with hardwired alarms (31 per cent). Many local authorities offer smoke alarm provision to their public-sector households. Whether this represents an effective and cost-effective use of resources requires further investigation.

Alcohol-related fan behavior on college football game day.

PubMed

Glassman, Tavis; Werch, Chudley E; Jobli, Edessa; Bian, Hui

2007-01-01

High-risk drinking on game day represents a unique public health challenge. The authors examined the drinking behavior of college football fans and assessed the support for related interventions. The authors randomly selected 762 football fans, including college students, alumni, and other college football fans, to complete an anonymous online game-day survey. The authors collected data on participants' drinking behaviors and support for specific game-day interventions. Analysis revealed that, overall, fans drank significantly more on game day than they did the last time they partied or socialized. Nondrinkers were the most supportive of game-day interventions, followed by moderate drinkers, whereas heavy drinkers offered the least support. With the exception of limiting tailgating hours on game day, fans support game-day interventions, including alcohol-free alternatives, designating tailgating areas where open containers are permitted, and increasing law enforcement efforts.

A Framework Approach to Evaluate Cross-Cultural Adaptation of Public Engagement Strategies for Radioactive Waste Management - 13430

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hermann, Laura

2013-07-01

The complex interplay of politics, economics and culture undermines attempts to define universal best practices for public engagement in the management of nuclear materials. In the international context, communicators must rely on careful adaptation and creative execution to make standard communication techniques succeed in their local communities. Nuclear professionals need an approach to assess and adapt culturally specific public engagement strategies to meet the demands of their particular political, economic and social structures. Using participant interviews and public sources, the Potomac Communications Group reviewed country-specific examples of nuclear-related communication efforts to provide insight into a proposed approach. The review consideredmore » a spectrum of cultural dimensions related to diversity, authority, conformity, proximity and time. Comparisons help to identify cross-cultural influences of various public engagement tactics and to inform a framework for communicators. While not prescriptive in its application, the framework offers a way for communicators to assess the salience of outreach tactics in specific situations. The approach can guide communicators to evaluate and tailor engagement strategies to achieve localized public outreach goals. (authors)« less

Beyond the three-component model of organizational commitment.

PubMed

Solinger, Omar N; van Olffen, Woody; Roe, Robert A

2008-01-01

This article offers a conceptual critique of the three-component model (TCM) of organizational commitment (Allen & Meyer, 1990) and proposes a reconceptualization based on standard attitude theory. The authors use the attitude-behavior model by Eagly and Chaiken (1993) to demonstrate that the TCM combines fundamentally different attitudinal phenomena. They argue that general organizational commitment can best be understood as an attitude regarding the organization, while normative and continuance commitment are attitudes regarding specific forms of behavior (i.e., staying or leaving). The conceptual analysis shows that the TCM fails to qualify as general model of organizational commitment but instead represents a specific model for predicting turnover. The authors suggest that the use of the TCM be restricted to this purpose and that Eagly and Chaiken's model be adopted as a generic commitment model template from which a range of models for predicting specific organizational behaviors can be extracted. Finally, they discuss the definition and measurement of the organizational commitment attitude. Covering the affective, cognitive, and behavioral facets of this attitude helps to enhance construct validity and to differentiate the construct from other constructs. 2008 APA

A mapping review of the literature on UK-focused health and social care databases.

PubMed

Cooper, Chris; Rogers, Morwenna; Bethel, Alison; Briscoe, Simon; Lowe, Jenny

2015-03-01

Bibliographic databases are a day-to-day tool of the researcher: they offer the researcher easy and organised access to knowledge, but how much is actually known about the databases on offer? The focus of this paper is UK health and social care databases. These databases are often small, specialised by topic, and provide a complementary literature to the large, international databases. There is, however, good evidence that these databases are overlooked in systematic reviews, perhaps because little is known about what they can offer. To systematically locate and map, published and unpublished literature on the key UK health and social care bibliographic databases. Systematic searching and mapping. Two hundred and forty-two items were identified which specifically related to the 24 of the 34 databases under review. There is little published or unpublished literature specifically analysing the key UK health and social care databases. Since several UK databases have closed, others are at risk, and some are overlooked in reviews, better information is required to enhance our knowledge. Further research on UK health and social care databases is required. This paper suggests the need to develop the evidence base through a series of case studies on each of the databases. © 2014 The authors. Health Information and Libraries Journal © 2014 Health Libraries Journal.

RNAi-based GM plants: food for thought for risk assessors.

PubMed

Ramon, Matthew; Devos, Yann; Lanzoni, Anna; Liu, Yi; Gomes, Ana; Gennaro, Andrea; Waigmann, Elisabeth

2014-12-01

RNA interference (RNAi) is an emerging technology that offers new opportunities for the generation of new traits in genetically modified (GM) plants. Potential risks associated with RNAi-based GM plants and issues specific to their risk assessment were discussed during an international scientific workshop (June 2014) organized by the European Food Safety Authority (EFSA). Selected key outcomes of the workshop are reported here. © 2014 Society for Experimental Biology, Association of Applied Biologists and John Wiley & Sons Ltd.

What results when firms implement practices: the differential relationship between specific practices, firm financial performance, customer service, and quality.

PubMed

Gibson, Cristina B; Porath, Christine L; Benson, George S; Lawler, Edward E

2007-11-01

Previous research on organizational practices is replete with contradictory evidence regarding their effects. Here, the authors argue that these contradictory findings may have occurred because researchers have often examined complex practice combinations and have failed to investigate a broad variety of firm-level outcomes. Thus, past research may obscure important differential effects of specific practices on specific firm-level outcomes. Extending this research, the authors develop hypotheses about the effects of practices that (a) enable information sharing, (b) set boundaries, and (c) enable teams on 3 different firm-level outcomes: financial performance, customer service, and quality. Relationships are tested in a sample of observations from over 200 Fortune 1000 firms. Results indicate that information-sharing practices were positively related to financial performance 1 year following implementation of the practices, boundary-setting practices were positively related to firm-level customer service, and team-enabling practices were related to firm-level quality. No single set of practices predicted all 3 firm-level outcomes, indicating practice-specific effects. These findings help resolve the theoretical tension in the literature regarding the effects of organizational practices and offer guidance as to how to best target practices to increase specific work-related outcomes. Implications for theory, research, and practice are discussed. (c) 2007 APA

The ethical commitments of academic faculty in psychiatric education.

PubMed

Green, Stephen A

2006-01-01

This article explores the commitment of faculty to ethics training in psychiatric education. Although psychiatry has insufficiently addressed the profession's need for ethics training in education, program directors acknowledge its critical importance, and its positive impact has been demonstrated. Additionally, residents often seek ethics training as part of their instruction. The author suggests that academic faculty could respond to the profession's inadequate treatment of ethics training by helping trainees develop moral agency--the ability to recognize, assess, and respond to ethical dilemmas; decide what constitutes right or wrong care; and act accordingly. The author also describes how this objective could be met by promoting professionalism and offering didactic instruction that address substantive and process issues regarding psychiatric care. Specific recommendations are provided.

Harmonizing Measures of Cognitive Performance Across International Surveys of Aging Using Item Response Theory.

PubMed

Chan, Kitty S; Gross, Alden L; Pezzin, Liliana E; Brandt, Jason; Kasper, Judith D

2015-12-01

To harmonize measures of cognitive performance using item response theory (IRT) across two international aging studies. Data for persons ≥65 years from the Health and Retirement Study (HRS, N = 9,471) and the English Longitudinal Study of Aging (ELSA, N = 5,444). Cognitive performance measures varied (HRS fielded 25, ELSA 13); 9 were in common. Measurement precision was examined for IRT scores based on (a) common items, (b) common items adjusted for differential item functioning (DIF), and (c) DIF-adjusted all items. Three common items (day of date, immediate word recall, and delayed word recall) demonstrated DIF by survey. Adding survey-specific items improved precision but mainly for HRS respondents at lower cognitive levels. IRT offers a feasible strategy for harmonizing cognitive performance measures across other surveys and for other multi-item constructs of interest in studies of aging. Practical implications depend on sample distribution and the difficulty mix of in-common and survey-specific items. © The Author(s) 2015.

Systematic and Open Identification of Researchers and Authors: Focus on Open Researcher and Contributor ID

PubMed Central

Akazhanov, Nurbek A.; Voronov, Alexander A.; Kitas, George D.

2014-01-01

Unique identifiers of researchers and authors can help all stakeholders of scientific communications improve their workflows. There have been several attempts to establish professional networks of scholars and list their scholarly achievements on digital platforms. Some of these platforms such as Google Scholar, Web of Knowledge and PubMed are searched to pick relevant peer reviewers, assess authors' publication history or choose suitable candidates for research and academic projects. However, each of these hubs has its specific applications, limiting the universal use for permanent tagging of researcher profiles. The Open Researcher and Contributor ID (ORCID) initiative, launched in 2012, is aimed at registering scholarly contributors and averting the persistent ambiguity of recorded author names. The ORCID registry is growing fast and integrating with other ID-generating platforms, thereby increasing the functionality of the integrated systems. ORCID identifiers are increasingly used for selecting peer reviewers and acknowledging various scholarly contributions (e.g., published articles, reviewer comments, conference presentations). The initiative offers unique opportunities for transparent disclosures of author contributions and competing interests and improving ethical standards of research, editing, and publishing. PMID:25408574

Systematic and open identification of researchers and authors: focus on open researcher and contributor ID.

PubMed

Gasparyan, Armen Yuri; Akazhanov, Nurbek A; Voronov, Alexander A; Kitas, George D

2014-11-01

Unique identifiers of researchers and authors can help all stakeholders of scientific communications improve their workflows. There have been several attempts to establish professional networks of scholars and list their scholarly achievements on digital platforms. Some of these platforms such as Google Scholar, Web of Knowledge and PubMed are searched to pick relevant peer reviewers, assess authors' publication history or choose suitable candidates for research and academic projects. However, each of these hubs has its specific applications, limiting the universal use for permanent tagging of researcher profiles. The Open Researcher and Contributor ID (ORCID) initiative, launched in 2012, is aimed at registering scholarly contributors and averting the persistent ambiguity of recorded author names. The ORCID registry is growing fast and integrating with other ID-generating platforms, thereby increasing the functionality of the integrated systems. ORCID identifiers are increasingly used for selecting peer reviewers and acknowledging various scholarly contributions (e.g., published articles, reviewer comments, conference presentations). The initiative offers unique opportunities for transparent disclosures of author contributions and competing interests and improving ethical standards of research, editing, and publishing.

Knowing what to sell, when, and to whom.

PubMed

Kumar, V; Venkatesan, Rajkumar; Reinartz, Werner

2006-03-01

Despite an abundance of data, most companies do a poor job of predicting the behavior of their customers. In fact, the authors' research suggests that even companies that take the greatest trouble over their predictions about whether a particular customer will buy a particular product are correct only around 55% of the time--a result that hardly justifies the costs of having a CRM system in the first place. Businesses usually conclude from studies like this that it's impossible to use the past to predict the future, so they revert to the timeworn marketing practice of inundating their customers with offers. But as the authors explain, the reason for the poor predictions is not any basic limitation of CRM systems or the predictive power of past behavior, but rather of the mathematical methods that companies use to interpret the data. The authors have developed a new way of predicting customer behavior, based on the work of the Nobel Prize-winning economist Daniel McFadden, that delivers vastly improved results. Indeed, the methodology increases the odds of successfully predicting a specific purchase by a specific customer at a specific time to about 85%, a number that will have a major impact on any company's marketing ROI. What's more, using this methodology, companies can increase revenues while reducing their frequency of customer contact-evidence that overcommunication with customers may actually damage a company's sales.

PRGdb 3.0: a comprehensive platform for prediction and analysis of plant disease resistance genes.

PubMed

Osuna-Cruz, Cristina M; Paytuvi-Gallart, Andreu; Di Donato, Antimo; Sundesha, Vicky; Andolfo, Giuseppe; Aiese Cigliano, Riccardo; Sanseverino, Walter; Ercolano, Maria R

2018-01-04

The Plant Resistance Genes database (PRGdb; http://prgdb.org) has been redesigned with a new user interface, new sections, new tools and new data for genetic improvement, allowing easy access not only to the plant science research community but also to breeders who want to improve plant disease resistance. The home page offers an overview of easy-to-read search boxes that streamline data queries and directly show plant species for which data from candidate or cloned genes have been collected. Bulk data files and curated resistance gene annotations are made available for each plant species hosted. The new Gene Model view offers detailed information on each cloned resistance gene structure to highlight shared attributes with other genes. PRGdb 3.0 offers 153 reference resistance genes and 177 072 annotated candidate Pathogen Receptor Genes (PRGs). Compared to the previous release, the number of putative genes has been increased from 106 to 177 K from 76 sequenced Viridiplantae and algae genomes. The DRAGO 2 tool, which automatically annotates and predicts (PRGs) from DNA and amino acid with high accuracy and sensitivity, has been added. BLAST search has been implemented to offer users the opportunity to annotate and compare their own sequences. The improved section on plant diseases displays useful information linked to genes and genomes to connect complementary data and better address specific needs. Through, a revised and enlarged collection of data, the development of new tools and a renewed portal, PRGdb 3.0 engages the plant science community in developing a consensus plan to improve knowledge and strategies to fight diseases that afflict main crops and other plants. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

Adding Apples and Oranges: Telecourses Are Both Different and Important.

ERIC Educational Resources Information Center

Hoffman, Leon C.

1982-01-01

Discusses advantages of offering telecourses at the college level and offers suggestions to make the courses first-rate educational offerings and first-rate learning experiences for students. (Author/JN)

Human Rights Treaties Are an Important Part of the "International Health Instrumentariam" Comment on "The Legal Strength of International Health Instruments - What It Brings to Global Health Governance?"

PubMed

Forman, Lisa

2017-10-02

In their commentary, Haik Nikogosian and Ilona Kickbusch argue for the necessity of new binding international legal instruments for health to address complex health determinants and offer a cogent analysis of the implications of such treaties for future global health governance. Yet in doing so they pay no attention to the existing instrumentarium of international legally binding treaties relevant to health, in the form of human rights treaties. International human rights law has entrenched individual entitlements and state obligations in relation to individual and public health through iterative human rights treaties since 1946. These treaties offer normative specificity, institutional monitoring and the possibility of enforcement and accountability. If we are to build a new 'international health instrumentariam' we should not ignore existing and important tools that can assist in this endeavor. © 2018 The Author(s); Published by Kerman University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The randomised controlled trial design: unrecognized opportunities for health sciences librarianship.

PubMed

Eldredge, Jonathan D

2003-06-01

to describe the essential components of the Randomised Controlled Trial (RCT) and its major variations; to describe less conventional applications of the RCT design found in the health sciences literature with potential relevance to health sciences librarianship; to discuss the limited number of RCTs within health sciences librarianship. narrative review supported to a limited extent with PubMed and Library Literature database searches consistent with specific search parameters. In addition, more systematic methods, including handsearching of specific journals, to identify health sciences librarianship RCTs. While many RCTs within the health sciences follow more conventional patterns, some RCTs assume certain unique features. Selected examples illustrate the adaptations of this experimental design to answering questions of possible relevance to health sciences librarians. The author offers several strategies for controlling bias in library and informatics applications of the RCT and acknowledges the potential of the electronic era in providing many opportunities to utilize the blinding aspects of RCTs. RCTs within health sciences librarianship inhabit a limited number of subject domains such as education. This limited scope offers both advantages and disadvantages for making Evidence-Based Librarianship (EBL) a reality. The RCT design offers the potential to answer far more EBL questions than have been addressed by the design to date. Librarians need only extend their horizons through use of the versatile RCT design into new subject domains to facilitate making EBL a reality.

Reference Images from Thin Sections of Lunar Regolith

NASA Technical Reports Server (NTRS)

Rickman Doug; Edmunson, Jennifer

2013-01-01

The specialist literature about the lunar regolith is massive. It is also highly focused on specific topics and effectively impenetrable to most non-geologists. Both characteristics of the literature present substantial hurdles to scientists and engineers interested in the regolith In the author's experience it neither surprising or unusual to find serious misconceptions about lunar-type materials outside of the lunar research community. Education of professionals who are non-geologists but interested in the regolith is impeded by a lack of some basic resources. One asset that has been missing is simply detailed images of the regolith "soil". While a few websites offer imagery of specific features, these are of course selected to illustrate specific features. It is almost impossible for a non-specialist to reason from these what "normal" or "typical" regolith looks like. Further, access to lunar material is highly restricted. And as publications rarely do not provide other than highly focused and narrowly tailored data, there is little potential for workers without personal access to sample to do any work with lunar material. To address both problems the authors have begun to make high resolution optical micrographs of entire thin sections of lunar regolith.

What does it mean to "employ" the RE-AIM model?

PubMed

Kessler, Rodger S; Purcell, E Peyton; Glasgow, Russell E; Klesges, Lisa M; Benkeser, Rachel M; Peek, C J

2013-03-01

Many grant proposals identify the use of a given evaluation model or framework but offer little about how such models are implemented. The authors discuss what it means to employ a specific model, RE-AIM, and key dimensions from this model for program planning, implementation, evaluation, and reporting. The authors report both conceptual and content specifications for the use of the RE-AIM model and a content review of 42 recent dissemination and implementation grant applications to National Institutes of Health that proposed the use of this model. Outcomes include the extent to which proposals addressed the overall RE-AIM model and specific items within the five dimensions in their methods or evaluation plans. The majority of grants used only some elements of the model (less than 10% contained thorough measures across all RE-AIM dimensions). Few met criteria for "fully developed use" of RE-AIM and the percentage of key issues addressed varied from, on average, 45% to 78% across the RE-AIM dimensions. The results and discussion of key criteria should help investigators in their use of RE-AIM and illuminate the broader issue of comprehensive use of evaluation models.

Domestic mobile satellite systems in North America

NASA Technical Reports Server (NTRS)

Wachira, Muya

1990-01-01

Telest Mobile Inc. (TMI) and the American Mobile Satellite Corporation (AMSC) are authorized to provide mobile satellite services (MSS) in Canada and the United States respectively. They are developing compatible systems and are undertaking joint specification and procurement of spacecraft and ground segment with the aim of operational systems by late 1993. Early entry (phase 1) mobile data services are offered in 1990 using space segment capacity leased from Inmarsat. Here, an overview is given of these domestic MSS with an emphasis on the TMI component of the MSAT systen.

Neurology didactic curricula for psychiatry residents: a review of the literature and a survey of program directors.

PubMed

Reardon, Claudia L; Walaszek, Art

2012-03-01

Minimal literature exists on neurology didactic instruction offered to psychiatry residents, and there is no model neurology didactic curriculum offered for psychiatry residency programs. The authors sought to describe the current state of neurology didactic training in psychiatry residencies. The authors electronically surveyed 172 directors of U.S. psychiatric residency training programs to examine the types and extent of neurology didactic instruction offered to their residents. Fifty-seven program directors (33%) responded. The majority of these psychiatry residency programs offer neurology didactic instruction to their residents, as provided by both neurology and psychiatry faculty, in a number of different settings and covering many topics. However, room for improvement likely remains. The authors hope this report will guide psychiatry residencies in optimizing their neurology didactic curricula. Further research should explore tools for assessing resident knowledge in neurology and measure the effectiveness of neurology curricula in increasing knowledge and improving clinical outcomes.

The role of assessment packages for diagnostic consultations: A conversation analytic perspective.

PubMed

Rossen, Camilla B; Buus, Niels; Stenager, Egon; Stenager, Elsebeth

2015-05-01

This article reports a conversation analysis of assessment package consultations. Healthcare delivery packages belong to a highly structured mode of healthcare delivery, in which specific courses of healthcare interventions related to assessment and treatment are predefined, both as to timing and content. Assessment packages are widely used in an increasing number of medical specialities; however, there is a lack of knowledge about how packaged assessment influences the interaction between doctor and patient. In this study, we investigate the final consultation in assessment packages, which is when the final clarification of the patient's symptoms takes place. The primary data of the study were eight audio recordings of consultations, and the secondary data were ethnographic field descriptions. In most consultations, packaged assessment was a resource as it provided fast and efficient clarification. In most cases, clarification was treated as good news since it either confirmed the absence of a serious disease or resulted in a diagnosis leading to relevant treatment offers. However, in some cases, clarification was not perceived as good news. This was the case in consultations with patients whose goal was to leave the consultation with clarification in the form of a definite diagnosis, but who were not offered such clarification. These patients negotiated the outcome of the consultation by applying implicit and explicit pressure, which induced the doctors to disregard the boundaries of the package and offer the patient more tests. The study highlights some of the problems related to introducing narrow, specialized package assessment. © The Author(s) 2014.

The prevalence and practice of academies of medical educators: a survey of U.S. medical schools.

PubMed

Searle, Nancy S; Thompson, Britta M; Friedland, Joan A; Lomax, James W; Drutz, Jan E; Coburn, Michael; Nelson, Elizabeth A

2010-01-01

Academies of medical educators can be defined as formal organizations of academic teaching faculty recognized for excellence in their contributions to their school's education mission and who, as a group, serve specific needs of the institution. The authors studied the characteristics of academies, including the processes for admission, selection, and retention of academy members; the types of faculty who are academy members; program goals; benefits offered by academies to the individual and to the institution; funding sources and amounts; and the rapid increase in academies since 2003. In 2008, the authors sent an online questionnaire to 127 U.S. medical schools. Responses were analyzed using descriptive statistics. To determine differences between groups, multivariate analysis of variance was performed. Correlation analysis (Pearson r) was used to identify association between variables. Effect size was determined using eta squared (eta2). Thirty-six of the 122 responding schools (96% response rate) reported having academies; 21 schools had initiated academies since 2003, and 33 schools were planning or considering academies. There was a statistically significant difference between academies established before 2004 and in 2004 regarding benefits offered to individuals, membership terms and maintenance requirements, and goals. Rogers' theory of the diffusion of innovation may explain the recent spread of academies. When beginning or reexamining existing academy programs, institutions should consider goals, application process, benefits offered to members as well as the institution, expendable resources, and means of support, because the final product depends on the choices made at the beginning.

Neurology Didactic Curricula for Psychiatry Residents: A Review of the Literature and a Survey of Program Directors

ERIC Educational Resources Information Center

Reardon, Claudia L.; Walaszek, Art

2012-01-01

Objective: Minimal literature exists on neurology didactic instruction offered to psychiatry residents, and there is no model neurology didactic curriculum offered for psychiatry residency programs. The authors sought to describe the current state of neurology didactic training in psychiatry residencies. Methods: The authors electronically…

48 CFR 50.205-3 - Authorization of offers contingent upon SAFETY Act designation or certification before contract...

Code of Federal Regulations, 2010 CFR

2010-10-01

...; (2) To the contracting officer's knowledge, the Government has not provided advance notice so that... competition without SAFETY Act protections or the subject technology would be sold to the Government only with SAFETY Act protections. (b) Contracting officers shall not authorize offers contingent upon obtaining a...

Therapeutic jurisprudence and outpatient commitment law: Kendra's Law and case study.

PubMed

Perlin, Michael L

2003-01-01

This article considers the implications of assisted outpatient commitment laws (OPC), with specific focus on New York's "Kendra's Law" through the lens of therapeutic jurisprudence (TJ). In this article, the author offers perspectives on the relationship between involuntary civil commitment, outpatient commitment, and the concept of the "least restrictive alternative"; considers pertinent empirical research, and looks at OPC's controversial relationship to forced drugging. Here, the civil libertarian critique is briefly considered, as well as the MacArthur Research Network research. Finally, the author looks closely at Kendra's Law, providing a brief overview of the law itself, and identifying some "pressure points" and pivotal issues, and considers the TJ implications of Kendra's Law, to determine how it "fits" into the public's "take" on all of mental disability law.

Capturing Crime: The Qualitative Analysis of Individual Cases for Advancing Criminological Knowledge.

PubMed

Wright, Kevin A; Bouffard, Leana A

2016-02-01

The qualitative analysis of individual cases has a prominent place in the development of criminological theory, yet progression in the scientific study of crime has largely been viewed as a distinctly quantitative endeavor. In the process, much of the theoretical depth and precision supplied by earlier methods of criminological knowledge production have been sacrificed. The current work argues for a return to our criminological roots by supplementing quantitative analyses with the qualitative inspection of individual cases. We provide a specific example of a literature (i.e., criminal specialization/versatility) that has become increasingly quantitative and could benefit from the use of the proposed approach. We conclude by offering additional areas of research that might be advanced by our framework presented here. © The Author(s) 2014.

How to be a good academic leader.

PubMed

Detsky, Allan S

2011-01-01

Individuals who take on leadership positions in academic health science centers help facilitate the mission of those institutions. However, they are often chosen on the basis of success in the core activities in research, education and patient care rather than on the basis of demonstrated leadership and management skills. Indeed, most academic leaders in the past have "learned on the job." This commentary provides practical advice on how to be an effective leader on the basis of the author's experiences as a Division Head and Chief of Medicine. It covers six themes (vision, managerial style, knowledge, people skills, organizational orientation and personal development) and offers 21 specific suggestions, one for each year of the author's leadership. It is hoped that this experience-derived advice will help future leaders in academic medicine.

[The De affectibus oris, of Vittorio Trincavella of Venice].

PubMed

Vidal, F

1993-01-01

The author states that starting with a work published in 1575 in the city of Venice, it is possible to rebuild in a complete way the Dentistry History of the XVI century; it is indeed an important testimony considering specially the lack of existing information and of authors dedicated specifically to this subject. The article center its interest in the Book number V and in the 13 chapters it is composed of and where there are described the common affections of the mouth and its surroundings. It is also given a biography of Trincavella and a panorama of Medicine of that time and by XVI and XVII centuries. Prof. Vidal offers also the translation from latin to french of Vittorio Trincavella, text made by Jean Marc Galeazzi, Paris.

Paying Research Participants: Regulatory Uncertainty, Conceptual Confusion, and a Path Forward.

PubMed

Largent, Emily A; Fernandez Lynch, Holly

The practice of offering payment to individuals in exchange for their participation in clinical research is widespread and longstanding. Nevertheless, such payment remains the source of substantial debate, in particular about whether or the extent to which offers of payment coerce and/or unduly induce individuals to participate. Yet, the various laws, regulations, and ethical guidelines that govern the conduct of human subjects research offer relatively little in the way of specific guidance regarding what makes a payment offer ethically acceptable-or not. Moreover, there is a lack of definitional agreement regarding what the terms coercion and undue inducement mean in the human subjects research context. It is, therefore, unsurprising that investigators and Institutional Review Boards (IRBs) experience confusion about how to evaluate offers of payment, and lean toward conservative approaches. These trends are exemplified by our pilot data regarding the ways in which some IRB members and investigators (mis)understand the concepts of coercion and undue inducement, as well as the ways in which certain research institutions oversee offers of payment at a local level. This article systematically examines the legal and ethical dimensions of offering payment to research participants. It argues that many concerns about offers of payment to research participants can be attributed to the misguided view that such offers ought to be treated differently than offers of payment in other contexts, a form of "research exceptionalism." We show that rejection of research exceptionalism with respect to payment helps settle open debates about both how best to define coercion and undue influence, and how to understand the relation between these concepts and offers of payment. We argue for adoption of our preferred definitions, ideally by regulatory authorities, and against the conventional conservatism toward payment of research participants. Instead, we draw attention to the rarely asked, even radical, question: are research participants paid enough ? We conclude by arguing that we ought to change the default to favor, rather than encourage suspicion of, offers of payment to research participants.

School closure as an influenza mitigation strategy: how variations in legal authority and plan criteria can alter the impact.

PubMed

Potter, Margaret A; Brown, Shawn T; Cooley, Phillip C; Sweeney, Patricia M; Hershey, Tina B; Gleason, Sherrianne M; Lee, Bruce Y; Keane, Christopher R; Grefenstette, John; Burke, Donald S

2012-11-14

States' pandemic influenza plans and school closure statutes are intended to guide state and local officials, but most faced a great deal of uncertainty during the 2009 influenza H1N1 epidemic. Questions remained about whether, when, and for how long to close schools and about which agencies and officials had legal authority over school closures. This study began with analysis of states' school-closure statutes and pandemic influenza plans to identify the variations among them. An agent-based model of one state was used to represent as constants a population's demographics, commuting patterns, work and school attendance, and community mixing patterns while repeated simulations explored the effects of variations in school closure authority, duration, closure thresholds, and reopening criteria. The results show no basis on which to justify statewide rather than school-specific or community-specific authority for school closures. Nor do these simulations offer evidence to require school closures promptly at the earliest stage of an epidemic. More important are criteria based on monitoring of local case incidence and on authority to sustain closure periods sufficiently to achieve epidemic mitigation. This agent-based simulation suggests several ways to improve statutes and influenza plans. First, school closure should remain available to state and local authorities as an influenza mitigation strategy. Second, influenza plans need not necessarily specify the threshold for school closures but should clearly define provisions for early and ongoing local monitoring. Finally, school closure authority may be exercised at the statewide or local level, so long as decisions are informed by monitoring incidence in local communities and schools.

The specificity triad: notions of disease and therapeutic specificity in biomedical reasoning

PubMed Central

2014-01-01

Biomedicine is typically defined as the branch of medicine that is based on the principles of biology and biochemistry. A central tenet for biomedicine is the notion of disease and therapeutic specificity, i.e. the idea of tailored treatments for discrete disorders underpinned by specific pathologies. The present paper is concerned with how notions of disease and therapeutic specificity guide biomedical reasoning. To that end, the author proposes a model – the specificity triad – that draws on late philosopher and physician Ludwik Fleck’s concept of “style of thought” to offer a frame for investigating the intricate process through which links between disorders, mechanisms, and therapeutics are established by biomedicine. Next by applying the specificity triad model to scrutinize research efforts in two discrete areas of medicine—psychiatry and regenerative medicine—this paper seeks to stimulate pertinent discussions in and about biomedicine. These include discussions on the ambiguous epistemic status of psychiatry within contemporary biomedicine, as well as the relationship between developmental biology — historically relatively disjointed from biomedical enterprise — and the burgeoning field of regenerative medicine. PMID:25326797

Assessing the relationship between Section 404 and wetland losses: a feasibility study

USGS Publications Warehouse

Gladwin, Douglas N.; Roelle, James E.; Asherin, Duane A.

1989-01-01

The primary objective of the Clean Water Act of 1977 (33 U.S.C. 1251) is to restore and maintain the physical, chemical, and biological integrity of the Nation's waters. Section 404 of the Act regulates the discharge of dredged or fill materials into wetlands and represents the primary Federal authority for regulation of wetland alterations. Since its inception, the Section 404 program has been controversial in regard to the extent to which it was intended to provide wetlands regulation. Section 404 requires those who wish to discharge dredged or fill material into waters of the United States, which include many wetlands, to first obtain a Federal permit. The Environmental Protection Agency (EPA) has overall responsibility for administration of the Section 404 program and promulgates guidelines that must be followed in issuing permits. In addition, EPA has the final authority to prohibit specific discharges if the environmental impacts are unacceptable. The U.S. Army Corps of Engineers (Corps) issues Section 404 permits, which can be of two types. Individual Permits are issued following case-by-case reviews of proposed discharges. General Permits, which can be either nationwide or regional in scope, are authorized by the Corps for categories of activities that are similar in nature and that have only minimal individual and cumulative adverse environmental impacts. EPA, the National Marine Fisheries Service (NMFS), the Fish and Wildlife Service (Service), and State natural resource agencies review and comment on permit applications and offer recommendations on appropriate mitigation measures. Although comments from the Service and other natural resource agencies are advisory in nature (EPA's veto authority excepted), they can serve as the basis for modifying, conditioning, or denying a Section 404 permit. In 1986, in a survey conducted by the National Ecology Research Center, Service personnel indicated interest in additional information concerning both wetland trends and the impacts of activities authorized by the Corps under Section 404 (Roelle 1986). Although there is some information concerning wetland losses for certain geographic areas and for the Nation as a whole (Frayer et al. 1983; Tiner 1984), there appears to be little information on how these losses relate to the Section 404 permitting process. The primary objective of this study was to determine the feasibility of estimating wetland losses in relationship to Individual and General Permits issued under Section 404. A secondary objective was to assemble data on acceptance and implementation of specific mitigation recommendations offered by the Service and other natural resource agencies in connection with development activities on wetlands examined. At present, 26 categories of Nationwide permits have been authorized by the Corps. Nationwide permit 26 was of particular interest in this study because it specifically authorizes discharges into wetlands under certain circumstances (see Figure 1 and related text for a more complete discussion of circumstances under which Nationwide Permit 26 is applicable). All subsequent references to Nationwide or General permits pertain to Nationwide Permit 26.

Care homes and the Mental Capacity Act 2005: Changes in understanding and practice over time.

PubMed

Manthorpe, Jill; Samsi, Kritika

2016-07-01

The Mental Capacity Act 2005 provides the legal framework in England and Wales for the making of decisions in respect of people who have never had or have lost decision-making capacity. As part of a 5-year research program investigating the implementation and adoption of the Mental Capacity Act in dementia practice, we interviewed staff working in different care homes at two time points (32 staff at Time 1 in 2008 and 27 staff at Time 2 in 2012) in South East England. At baseline Time 1, daily practice seemed to resonate with Mental Capacity Act principles of respecting decisions and trying to act in a person's best interests. This paper reports Time 2 findings. We found that few care home staff interviewed specifically reported finding the Mental Capacity Act helpful in crystallizing the legal basis of their work. Most continued to offer illustrations of day-to-day practice in which they paid attention to individual choices, took account of the wishes of residents' families, and tried to act in residents' best interests but referred major decisions to their seniors. This study highlights the potential of referring to specific day-to-day practice in care homes when offering training or scrutinizing practice in dementia care more generally so that the work is set in its legal as well as moral framework. Care home staff in this study reported that advanced planning and pre-specifying preferences were more common among new care home residents, especially those with dementia, indicating that greater understanding of these is required by staff. © The Author(s) 2014.

Fifteen hundred guidelines and growing: the UK database of clinical guidelines.

PubMed

van Loo, John; Leonard, Niamh

2006-06-01

The National Library for Health offers a comprehensive searchable database of nationally approved clinical guidelines, called the Guidelines Finder. This resource, commissioned in 2002, is managed and developed by the University of Sheffield Health Sciences Library. The authors introduce the historical and political dimension of guidelines and the nature of guidelines as a mechanism to ensure clinical effectiveness in practice. The article then outlines the maintenance and organisation of the Guidelines Finder database itself, the criteria for selection, who publishes guidelines and guideline formats, usage of the Guidelines Finder service and finally looks at some lessons learnt from a local library offering a national service. Clinical guidelines are central to effective clinical practice at the national, organisational and individual level. The Guidelines Finder is one of the most visited resources within the National Library for Health and is successful in answering information needs related to specific patient care, clinical research, guideline development and education.

Arm position during ambulatory blood pressure monitoring: a review of the evidence and clinical guidelines.

PubMed

Byrd, James B; Brook, Robert D

2014-03-01

Ambulatory blood pressure monitoring (ABPM) offers advantages over clinic blood pressure measurement. Supporting the arm at the level of the right atrium has long been standard in clinic blood pressure measurement. In contrast, there is no consensus regarding arm position in the guidelines addressing ABPM. Research studies have used a variety of arm positions during ABPM. Discussed in this review are the merits of ABPM and a review of the several arm positions recommended in ABPM guidelines, suggested by cuff manufacturers, and used in research studies. To address this lack of standardization, a rationale for a clinically reasonable arm position during ABPM is offered. Specifically, the authors recommend advising the patient to keep the arm still and relaxed straight down at the side of the body when the cuff is going to inflate, when safe to do so. ©2014 Wiley Periodicals, Inc.

MONTE CARLO SIMULATION OF THE BREMSSTRAHLUNG RADIATION FOR THE MEASUREMENT OF AN INTERNAL CONTAMINATION WITH PURE-BETA EMITTERS IN VIVO.

PubMed

Fantínová, K; Fojtík, P; Malátová, I

2016-09-01

Rapid measurement techniques are required for a large-scale emergency monitoring of people. In vivo measurement of the bremsstrahlung radiation produced by incorporated pure-beta emitters can offer a rapid technique for the determination of such radionuclides in the human body. This work presents a method for the calibration of spectrometers, based on the use of UPh-02T (so-called IGOR) phantom and specific (90)Sr/(90)Y sources, which can account for recent as well as previous contaminations. The process of the whole- and partial-body counter calibration in combination with application of a Monte Carlo code offers readily extension also to other pure-beta emitters and various exposure scenarios. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Comparative Study of Three Different Personal Response Systems with Fourth-Year Undergraduate Veterinary Students.

PubMed

Duret, Denis; Senior, Avril

2015-01-01

The purpose of this study was to compare three different Personal Response Systems that have been used in recent years at the School of Veterinary Science, University of Liverpool: a technology-free system (Communicubes), a handset delivery device (TurningPoint), and a cloud-based technology (Poll Everywhere) that allows students to use a range of personal computing devices to register their answer. All three systems offer a method to promote active learning, and lecturers were encouraged to use them. However, there are cost and logistical implications for each. The authors found that both staff and students did have particular preferences for a specific system. This preference was not the same for both groups. The outcome of the comparison is that further research is needed into cloud-based technology as it offers benefits to the students but is also a distraction.

Moral disengagement in ethical decision making: a study of antecedents and outcomes.

PubMed

Detert, James R; Treviño, Linda Klebe; Sweitzer, Vicki L

2008-03-01

This article advances understanding of the antecedents and outcomes of moral disengagement by testing hypotheses with 3 waves of survey data from 307 business and education undergraduate students. The authors theorize that 6 individual differences will either increase or decrease moral disengagement, defined as a set of cognitive mechanisms that deactivate moral self-regulatory processes and thereby help to explain why individuals often make unethical decisions without apparent guilt or self-censure (Bandura, 1986). Results support 4 individual difference hypotheses, specifically, that empathy and moral identity are negatively related to moral disengagement, while trait cynicism and chance locus of control orientation are positively related to moral disengagement. Two additional locus of control orientations are not significantly related to moral disengagement. The authors also hypothesize and find that moral disengagement is positively related to unethical decision making. Finally, the authors hypothesize that moral disengagement plays a mediating role between the individual differences they studied and unethical decisions. Their results offer partial support for these mediating hypotheses. The authors discuss the implications of these findings for future research and for practice. Copyright 2008 APA

Someone has to give in: theta oscillations correlate with adaptive behavior in social bargaining.

PubMed

Billeke, Pablo; Zamorano, Francisco; López, Tamara; Rodriguez, Carlos; Cosmelli, Diego; Aboitiz, Francisco

2014-12-01

During social bargain, one has to both figure out the others' intentions and behave strategically in such a way that the others' behaviors will be consistent with one's expectations. To understand the neurobiological mechanisms underlying these behaviors, we used electroencephalography while subjects played as proposers in a repeated ultimatum game. We found that subjects adapted their offers to obtain more acceptances in the last round and that this adaptation correlated negatively with prefrontal theta oscillations. People with higher prefrontal theta activity related to a rejection did not adapt their offers along the game to maximize their earning. Moreover, between-subject variation in posterior theta oscillations correlated positively with how individual theta activity influenced the change of offer after a rejection, reflecting a process of behavioral adaptation to the others' demands. Interestingly, people adapted better their offers when they knew that they where playing against a computer, although the behavioral adaptation did not correlate with prefrontal theta oscillation. Behavioral changes between human and computer games correlated with prefrontal theta activity, suggesting that low adaptation in human games could be a strategy. Taken together, these results provide evidence for specific roles of prefrontal and posterior theta oscillations in social bargaining. © The Author (2014). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

A baseline assessment of emergency planning and preparedness in Italian universities.

PubMed

Marincioni, Fausto; Fraboni, Rita

2012-04-01

Besides offering teaching and research services, schools and universities also must provide for the safety and security of their employees, students, and visitors. This paper describes emergency preparedness in a sample of Italian universities. In particular it examines risk perception within a specific professional category (university safety and security officers) in a specific cultural context (Italy). In addition, it discusses the transposition and implementation in a European Union (EU) member state of EU Council Directive 89/391/EEC of 12 June 1989, on the introduction of measures to encourage improvements in the safety and health of workers. The findings highlight heterogeneous and fragmented emergency management models within the Italian university system, underlining the need for a stricter framework of standardised safety protocols and emergency management guidelines. The study also points out that enhancing emergency planning and preparedness in Italian universities entails increasing safety leadership, employee engagement and individual responsibility for safety and security; essentially, it necessitates improving the culture of risk prevention. © 2012 The Author(s). Disasters © Overseas Development Institute, 2012.

Speciation through the lens of biomechanics: locomotion, prey capture and reproductive isolation.

PubMed

Higham, Timothy E; Rogers, Sean M; Langerhans, R Brian; Jamniczky, Heather A; Lauder, George V; Stewart, William J; Martin, Christopher H; Reznick, David N

2016-09-14

Speciation is a multifaceted process that involves numerous aspects of the biological sciences and occurs for multiple reasons. Ecology plays a major role, including both abiotic and biotic factors. Whether populations experience similar or divergent ecological environments, they often adapt to local conditions through divergence in biomechanical traits. We investigate the role of biomechanics in speciation using fish predator-prey interactions, a primary driver of fitness for both predators and prey. We highlight specific groups of fishes, or specific species, that have been particularly valuable for understanding these dynamic interactions and offer the best opportunities for future studies that link genetic architecture to biomechanics and reproductive isolation (RI). In addition to emphasizing the key biomechanical techniques that will be instrumental, we also propose that the movement towards linking biomechanics and speciation will include (i) establishing the genetic basis of biomechanical traits, (ii) testing whether similar and divergent selection lead to biomechanical divergence, and (iii) testing whether/how biomechanical traits affect RI. Future investigations that examine speciation through the lens of biomechanics will propel our understanding of this key process. © 2016 The Author(s).

Transportation or CT scanners: a theory and method of health resources allocation.

PubMed Central

Greenwald, H P; Woodward, J M; Berg, D H

1979-01-01

Cost containment and access to appropriate care are the two most frequently discussed issues in contemporary health policy. Conceiving of the health services available in specific regions as "packages" of diverse items, the authors of this article consider the economic trade-offs among the various resources needed for appropriate care. In the discussion that follows, we examine the trade-offs between two divergent offering of the health care system: high technology medicine and support services. Specifically, we examine several strategies designed to achieve an optimal mix of investments in CT scanners and transportation resources in the South Chicago region. Using linear programming as a method for examining these options, the authors found that 1) the proper location of CT scanners is as important for cost containment as optimal number, and 2) excess capacity in the utilization of a single resource--CT scanners--need not imply inefficiency in the overall delivery of the service. These findings help demonstrate the importance of viewing health care as a package of interrelated services, both for achieving cost containment and for providing access to appropriate care. PMID:391772

Primary Care Providers' Knowledge and Practices of Diabetes Management During Ramadan.

PubMed

Ali, Mujtaba; Adams, Alexandra; Hossain, Md Anwar; Sutin, David; Han, Benjamin Hyun

2016-01-01

There are an estimated 3.5 million Muslims in North America. During the holy month of Ramadan, healthy adult Muslims are to fast from predawn to after sunset. While there are exemptions for older and sick adults, many adults with diabetes fast during Ramadan. However, there are risks associated with fasting and specific management considerations for patients with diabetes. We evaluated provider practices and knowledge regarding the management of patients with diabetes who fast during Ramadan. A 15-question quality improvement survey based on a literature review and the American Diabetes Association guidelines was developed and offered to providers at the outpatient primary care and geriatric clinics at an inner-city hospital in New York City. Forty-five providers completed the survey. Most respondents did not ask their Muslim patients with diabetes if they were fasting during the previous Ramadan. Knowledge of fasting practices during Ramadan was variable, and most felt uncomfortable managing patients with diabetes during Ramadan. There is room for improvement in educating providers about specific cultural and medical issues regarding fasting for patients with diabetes during Ramadan. © The Author(s) 2015.

The application of quantum mechanics in structure-based drug design.

PubMed

Mucs, Daniel; Bryce, Richard A

2013-03-01

Computational chemistry has become an established and valuable component in structure-based drug design. However the chemical complexity of many ligands and active sites challenges the accuracy of the empirical potentials commonly used to describe these systems. Consequently, there is a growing interest in utilizing electronic structure methods for addressing problems in protein-ligand recognition. In this review, the authors discuss recent progress in the development and application of quantum chemical approaches to modeling protein-ligand interactions. The authors specifically consider the development of quantum mechanics (QM) approaches for studying large molecular systems pertinent to biology, focusing on protein-ligand docking, protein-ligand binding affinities and ligand strain on binding. Although computation of binding energies remains a challenging and evolving area, current QM methods can underpin improved docking approaches and offer detailed insights into ligand strain and into the nature and relative strengths of complex active site interactions. The authors envisage that QM will become an increasingly routine and valued tool of the computational medicinal chemist.

Gas dynamic design of the pipe line compressor with 90% efficiency. Model test approval

NASA Astrophysics Data System (ADS)

Galerkin, Y.; Rekstin, A.; Soldatova, K.

2015-08-01

Gas dynamic design of the pipe line compressor 32 MW was made for PAO SMPO (Sumy, Ukraine). The technical specification requires compressor efficiency of 90%. The customer offered favorable scheme - single-stage design with console impeller and axial inlet. The authors used the standard optimization methodology of 2D impellers. The original methodology of internal scroll profiling was used to minimize efficiency losses. Radically improved 5th version of the Universal modeling method computer programs was used for precise calculation of expected performances. The customer fulfilled model tests in a 1:2 scale. Tests confirmed the calculated parameters at the design point (maximum efficiency of 90%) and in the whole range of flow rates. As far as the authors know none of compressors have achieved such efficiency. The principles and methods of gas-dynamic design are presented below. The data of the 32 MW compressor presented by the customer in their report at the 16th International Compressor conference (September 2014, Saint- Petersburg) and later transferred to the authors.

Community-based medical education: is success a result of meaningful personal learning experiences?

PubMed

Kelly, Len; Walters, Lucie; Rosenthal, David

2014-01-01

Community-based medical education (CBME) is the delivery of medical education in a specific social context. Learners become a part of social and medical communities where their learning occurs. Longitudinal integrated clerkships (LICs) are year-long community-based placements where the curriculum and clinical experience is typically delivered by primary care physicians. These programs have proven to be robust learning environments, where learners develop strong communication skills and excellent clinical reasoning. To date, no learning model has been offered to describe CBME. The characteristics of CBME are explored by the authors who suggest that the social and professional context provided in small communities enhances medical education. The authors postulate that meaningfulness is engendered by the authentic context, which develops over time. These relationships with preceptors, patients and the community provide meaningfulness, which in turn enhances learning. The authors develop a novel learning model. They propose that the context-rich environment of CBME allows for meaningful relationships and experiences for students and that such meaningfulness enhances learning.

Human resources management and firm performance: The differential role of managerial affective and continuance commitment.

PubMed

Gong, Yaping; Law, Kenneth S; Chang, Song; Xin, Katherine R

2009-01-01

In this study, the authors developed a dual-concern (i.e., maintenance and performance) model of human resources (HR) management. The authors identified commonly examined HR practices that apply to the middle manager level and classified them into the maintenance- and performance-oriented HR subsystems. The authors found support for the 2-factor model on the basis of responses from 2,148 managers from 463 firms operating in China. Regression results indicate that the performance-oriented HR subsystems had a positive relationship with firm performance and that the relationship was mediated by middle managers' affective commitment to the firm. The maintenance-oriented HR subsystems had a positive relationship with middle managers' continuance commitment but not with their affective commitment and firm performance. This study contributes to the understanding of how HR practices relate to firm performance and offers an improved test of the argument that valuable and firm-specific HR provide a source of competitive advantage. (PsycINFO Database Record (c) 2009 APA, all rights reserved).

Cosmetic websites Scotland: legal or lurid.

PubMed

Gunn, Eilidh G M; Loh, Charles Yuen Yung; Athanassopoulos, Thanassi

2014-08-01

The provision of cosmetic interventions and their advertising have recently come under intense scrutiny in the wake of the PIP scandal and Keogh report. A study of Scottish websites offering esthetic procedures was conducted to determine adherence to the advertising standards and regulations currently in place. Regulations are provided by the Advertising Standards Authority, Committee on Advertising Practice, Independent Healthcare Advisory Services and General Medical Council. An Internet search was then conducted to search for providers of non-surgical and surgical cosmetic procedures. Overall 125 websites were reviewed. 109 local and 16 national with 17 websites associated with cosmetic surgeons. 26 websites failed to adhere to regulations. Failure was related to advertising of POM on the homepage or dropdown menu (20), offering enticements inappropriately (6). 26.6% of websites did not display qualifications of the practitioners. Only 16.6% of websites described the specific and the non-specific side effects of "anti-wrinkle injections" and only 12.5% mentioned alternative treatments. The majority of websites reviewed adhered to current advertising standards. Plastic surgeons provide a small percentage of cosmetic procedures. Greater regulation at the point of product entry and of all esthetic practitioners is required. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

A Management Model for International Participation in Space Exploration Missions

NASA Technical Reports Server (NTRS)

George, Patrick J.; Pease, Gary M.; Tyburski, Timothy E.

2005-01-01

This paper proposes an engineering management model for NASA's future space exploration missions based on past experiences working with the International Partners of the International Space Station. The authors have over 25 years of combined experience working with the European Space Agency, Japan Aerospace Exploration Agency, Canadian Space Agency, Italian Space Agency, Russian Space Agency, and their respective contractors in the design, manufacturing, verification, and integration of their elements electric power system into the United States on-orbit segment. The perspective presented is one from a specific sub-system integration role and is offered so that the lessons learned from solving issues of technical and cultural nature may be taken into account during the formulation of international partnerships. Descriptions of the types of unique problems encountered relative to interactions between international partnerships are reviewed. Solutions to the problems are offered, taking into consideration the technical implications. Through the process of investigating each solution, the important and significant issues associated with working with international engineers and managers are outlined. Potential solutions are then characterized by proposing a set of specific methodologies to jointly develop spacecraft configurations that benefits all international participants, maximizes mission success and vehicle interoperability while minimizing cost.

Business plan to establish a CT colonography service.

PubMed

Fajardo, Laurie L; Hurley, James P; Brown, Bruce P; Summers, Robert W; McDaniel, R Donald

2006-03-01

The authors describe the University of Iowa Department of Radiology's business planning process to initiate a new service in computed tomographic colonography (CTC). Also known as virtual colonoscopy, CTC is a noninvasive technology that offers less risk, and potentially similar sensitivity and specificity, than conventional optical colonoscopy (OC). Although not currently covered by all insurance payers, about a year ago, the Centers for Medicare and Medicaid Services instituted temporary Current Procedural Terminology codes (Category III) for CTC. In locales where the procedure is not covered by insurers, it is likely to be sought by patients willing to pay out of pocket to undergo noninvasive cancer screening as an alternative to OC. Thus, CTC could become the preferred method of colon cancer surveillance by insurance providers in the near future. In developing the business plan, the authors reviewed pertinent scientific and clinical data to evaluate the need for and efficacy of CTC. Local market data were used to estimate patient and procedure volumes and utilization. The authors modeled financial expectations with respect to return on investment on the basis of recently reported models specific to CTC, resource requirements, and the operational impact of the new service on existing hospital and departmental clinical functions. Because there are few local providers of CTC in the authors' region, the business plan also included a publicity campaign and plan to market the new service, stimulate general public interest early, and differentiate the program as a leader in applying this unique new technology to promote cancer screening. Finally, the planning committee acknowledged and accommodated needs specific to the missions of an academic medical center with respect to research and education in designing the new service.

Deciding about patients' requests for extraction: ethical and legal guidelines.

PubMed

Broers, Dyonne L M; Brands, Wolter G; Welie, Jos V M; de Jongh, Ad

2010-02-01

and Overview. Dentists frequently are faced with patients' requests for an extraction, sometimes of the entire dentition. In this article, the authors offer guidelines to help dentists and oral surgeons make decisions regarding such requests for extraction. In most cases of patients' requesting extractions, the ethical principle of nonmaleficence will play a decisive role in the dentist's decision making. In cases in which the request appears influenced by a specific mental condition such as a phobia of dental treatment, extraction rarely is justifiable. Practice Implications. Dental professionals should keep in mind that they cannot be forced to carry out treatment that is at odds with the ethical principle of nonmaleficence or that is outside of the bounds of accepted treatment. To aid dentists in making treatment decisions in such cases, the authors present a flowchart that integrates possible considerations.

Response to "Discourse over a contested technology on Twitter: A case study of hydraulic fracturing"-Word choice as political speech.

PubMed

Grubert, Emily

2016-01-22

Hopke and Simis (Public Understanding of Science, online 4 October 2015) find that #fracking, the most popular of five shale-related hashtags analyzed from a 2013 period, is associated with pro-shale attitudes only 13% of the time and note that the dominant voice of the activist community, coupled with a lack of engagement from industry, is unexpected. This comment offers additional perspective on the sentiment- and actor-skewed result by noting that the term "fracking" is highly political, specifically because the spelling "frack" versus "frac" is associated with activism. Furthermore, in public speech, the industry tends to deemphasize the hydraulic fracturing process in favor of the product, consistent with the findings that #natgas is a relatively pro-industry hashtag. © The Author(s) 2016.

Developing Your Own Microcomputer Courseware with Authoring Tools.

ERIC Educational Resources Information Center

Hodges, James O.

1985-01-01

For social studies teachers who want to create their own software, authoring systems and authoring languages offer an interesting avenue to be explored. An authoring system available from Courseware, Inc., (California) and the authoring language PILOT available from Apple Computer (California) are described. (RM)

Virtual patients: practical advice for clinical authors using Labyrinth.

PubMed

Begg, Michael

2010-09-01

Labyrinth is a tool originally developed in the University of Edinburgh's Learning Technology Section for authoring and delivering branching case scenarios. The scenarios can incorporate game-informed elements such as scoring, randomising, avatars and counters. Labyrinth has grown more popular internationally since a version of the build was made available on the open source network Source Forge. This paper offers help and advice for clinical educators interested in creating cases. Labyrinth is increasingly recognised as a tool offering great potential for delivering cases that promote rich, situated learning opportunities for learners. There are, however, significant challenges to generating such cases, not least of which is the challenge for potential authors in approaching the process of constructing narrative-rich, context-sensitive cases in an unfamiliar authoring environment. This paper offers a brief overview of the principles informing Labyrinth cases (game-informed learning), and offers some practical advice to better prepare educators with little or no prior experience. Labyrinth has continued to grow and develop, from its roots as a research and development environment to one that is optimised for use by non-technical clinical educators. The process becomes increasingly iterative and better informed as the teaching community push the software further. The positive implications of providing practical advice and concept insight to new case authors is that it ideally leads to a broader base of users who will inform future iterations of the software. © Blackwell Publishing Ltd 2010.

DSM-III as a research tool.

PubMed

Treece, C

1982-05-01

The author describes the use of the DSM-III's diagnostic criteria and classification system as a research instrument and discusses some of the advantages and drawbacks of DMS-III for a specific type of study. A rearrangement of the hierarchical order of the DSM-III diagnostic classes is suggested. This rearrangement provides for levels of certainty in analyzing interrater reliability and offers a simplified framework for summarizing group data. When this approach is combined with a structured interview and response format, it provides a flexible way of managing a large classification system for a smaller study without sacrificing standardization.

NERC Policy 10: Measurement of two generation and load balancing IOS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spicer, P.J.; Galow, G.G.

1999-11-01

Policy 10 will describe specific standards and metrics for most of the reliability functions described in the Interconnected Operations Services Working Group (IOS WG) report. The purpose of this paper is to discuss, in detail, the proposed metrics for two generation and load balancing IOSs: Regulation; Load Following. For purposes of this paper, metrics include both measurement and performance evaluation. The measurement methods discussed are included in the current draft of the proposed Policy 10. The performance evaluation method discussed is offered by the authors for consideration by the IOS ITF (Implementation Task Force) for inclusion into Policy 10.

The new hospice compliance plan: defining and addressing risk areas. Part 3.

PubMed

Jones, D H; Woods, K

2000-07-01

The recently released OIG guidelines to ensure compliance with federal and state statutes, rules, and regulations, and private-payor health care program requirements provide a blueprint for developing such programs. This is the last of three installments that focus specifically on the 28 risk areas identified in the guidance and offer strategies for incorporating them in a hospice compliance program. The authors have organized the 28 risk areas under 9 topic domains to simplify the task of tackling the guidance. This article covers the areas of nursing home care, marketing, and Conditions of Participation.

Boomerang flap reconstruction for the breast.

PubMed

Baumholtz, Michael A; Al-Shunnar, Buthainah M; Dabb, Richard W

2002-07-01

The boomerang-shaped latissimus dorsi musculocutaneous flap for breast reconstruction offers a stable platform for breast reconstruction. It allows for maximal aesthetic results with minimal complications. The authors describe a skin paddle to obtain a larger volume than either the traditional elliptical skin paddle or the extended latissimus flap. There are three specific advantages to the boomerang design: large volume, conical shape (often lacking in the traditional skin paddle), and an acceptable donor scar. Thirty-eight flaps were performed. No reconstruction interfered with patient's ongoing oncological regimen. The most common complication was seroma, which is consistent with other latissimus reconstructions.

Evaluation of Standards for Access Control Enabling PHR-S Federation.

PubMed

Mense, Alexander; Urbauer, Philipp; Sauermann, Stefan

2017-01-01

The adoption of the Internet of Things (IoT) and mobile applications in the healthcare may transform the healthcare industry by offering better disease tracking and management as well as patient empowerment. Unfortunately, almost all of these new systems set up their own ecosystem and to be really valuable for the care process they need to be integrated or federated with user managed access control services based on international standards and profiles to enable interoperability. Thus, this work presents the results of an evaluation of available specifications for federated authorization, based on a set of basic requirements.

Organizational change tactics: the evidence base in the literature.

PubMed

Packard, Thomas; Shih, Amber

2014-01-01

Planned organizational change processes can be used to address the many challenges facing human service organizations (HSOs) and improve organizational outcomes. There is massive literature on organizational change, ranging from popular management books to academic research on specific aspects of change. Regarding HSOs, there is a growing literature, including increasing attention to implementation science and evidence-based practices. However, research which offers generalizable, evidence-based guidelines for implementing change is not common. The purpose of the authors was to assess the evidence base in this organizational change literature to lay the groundwork for more systematic knowledge development in this important field.

Trade-off between fertility and predation risk drives a geometric sequence in the pattern of group sizes in baboons.

PubMed

Dunbar, R I M; MacCarron, Padraig; Robertson, Cole

2018-03-01

Group-living offers both benefits (protection against predators, access to resources) and costs (increased ecological competition, the impact of group size on fertility). Here, we use cluster analysis to detect natural patternings in a comprehensive sample of baboon groups, and identify a geometric sequence with peaks at approximately 20, 40, 80 and 160. We suggest (i) that these form a set of demographic oscillators that set habitat-specific limits to group size and (ii) that the oscillator arises from a trade-off between female fertility and predation risk. © 2018 The Authors.

Developing of method for primary frequency control droop and deadband actual values estimation

NASA Astrophysics Data System (ADS)

Nikiforov, A. A.; Chaplin, A. G.

2017-11-01

Operation of thermal power plant generation equipment, which participates in standardized primary frequency control (SPFC), must meet specific requirements. These requirements are formalized as nine algorithmic criteria, which are used for automatic monitoring of power plant participation in SPFC. One of these criteria - primary frequency control droop and deadband actual values estimation is considered in detail in this report. Experience shows that existing estimation method sometimes doesn’t work properly. Author offers alternative method, which allows estimating droop and deadband actual values more accurately. This method was implemented as a software application.

Financial Recruitment Incentive Programs for Nursing Personnel in Canada.

PubMed

Mathews, Maria; Ryan, Dana

2015-03-01

Financial incentives are increasingly offered to recruit nursing personnel to work in underserved communities. The authors describe and compare the characteristics of federal, provincial and territorial financial recruitment incentive programs for registered nurses (RNs), nurse practitioners (NPs), licensed practical nurses (LPNs), registered practical nurses or registered psychiatric nurses. The authors identified incentive programs from government, health ministry and student aid websites and by contacting program officials. Only government-funded recruitment programs providing funding beyond the normal employee wages and benefits and requiring a service commitment were included. The authors excluded programs offered by hospitals, regional or private firms, and programs that rewarded retention. All provinces and territories except QC and NB offer financial recruitment incentive programs for RNs; six provinces (BC, AB, SK, ON, QC and NL) offer programs for NPs, and NL offers a program for LPNs. Programs include student loan forgiveness, tuition forgiveness, education bursaries, signing bonuses and relocation expenses. Programs target trainees, recent graduates and new hires. Funding and service requirements vary by program, and service requirements are not always commensurate with funding levels. This snapshot of government-funded recruitment incentives provides program managers with data to compare and improve nursing workforce recruitment initiatives. Copyright © 2015 Longwoods Publishing.

Revisiting Information Technology tools serving authorship and editorship: a case-guided tutorial to statistical analysis and plagiarism detection

PubMed Central

Bamidis, P D; Lithari, C; Konstantinidis, S T

2010-01-01

With the number of scientific papers published in journals, conference proceedings, and international literature ever increasing, authors and reviewers are not only facilitated with an abundance of information, but unfortunately continuously confronted with risks associated with the erroneous copy of another's material. In parallel, Information Communication Technology (ICT) tools provide to researchers novel and continuously more effective ways to analyze and present their work. Software tools regarding statistical analysis offer scientists the chance to validate their work and enhance the quality of published papers. Moreover, from the reviewers and the editor's perspective, it is now possible to ensure the (text-content) originality of a scientific article with automated software tools for plagiarism detection. In this paper, we provide a step-bystep demonstration of two categories of tools, namely, statistical analysis and plagiarism detection. The aim is not to come up with a specific tool recommendation, but rather to provide useful guidelines on the proper use and efficiency of either category of tools. In the context of this special issue, this paper offers a useful tutorial to specific problems concerned with scientific writing and review discourse. A specific neuroscience experimental case example is utilized to illustrate the young researcher's statistical analysis burden, while a test scenario is purpose-built using open access journal articles to exemplify the use and comparative outputs of seven plagiarism detection software pieces. PMID:21487489

Revisiting Information Technology tools serving authorship and editorship: a case-guided tutorial to statistical analysis and plagiarism detection.

PubMed

Bamidis, P D; Lithari, C; Konstantinidis, S T

2010-12-01

With the number of scientific papers published in journals, conference proceedings, and international literature ever increasing, authors and reviewers are not only facilitated with an abundance of information, but unfortunately continuously confronted with risks associated with the erroneous copy of another's material. In parallel, Information Communication Technology (ICT) tools provide to researchers novel and continuously more effective ways to analyze and present their work. Software tools regarding statistical analysis offer scientists the chance to validate their work and enhance the quality of published papers. Moreover, from the reviewers and the editor's perspective, it is now possible to ensure the (text-content) originality of a scientific article with automated software tools for plagiarism detection. In this paper, we provide a step-bystep demonstration of two categories of tools, namely, statistical analysis and plagiarism detection. The aim is not to come up with a specific tool recommendation, but rather to provide useful guidelines on the proper use and efficiency of either category of tools. In the context of this special issue, this paper offers a useful tutorial to specific problems concerned with scientific writing and review discourse. A specific neuroscience experimental case example is utilized to illustrate the young researcher's statistical analysis burden, while a test scenario is purpose-built using open access journal articles to exemplify the use and comparative outputs of seven plagiarism detection software pieces.

Working toward financial sustainability of integrated behavioral health services in a public health care system.

PubMed

Monson, Samantha Pelican; Sheldon, J Christopher; Ivey, Laurie C; Kinman, Carissa R; Beacham, Abbie O

2012-06-01

The need, benefit, and desirability of behavioral health integration in primary care is generally accepted and has acquired widespread positive regard. However, in many health care settings the economics, business aspects, and financial sustainability of practice in integrated care settings remains an unsolved puzzle. Organizational administrators may be reluctant to expand behavioral health services without evidence that such programs offer clear financial benefits and financial sustainability. The tendency among mental health professionals is to consider positive clinical outcomes (e.g., reduced depression) as being globally valued indicators of program success. Although such outcomes may be highly valued by primary care providers and patients, administrative decision makers may require demonstration of more tangible financial outcomes. These differing views require program developers and evaluators to consider multiple outcome domains including clinical/psychological symptom reduction, potential cost benefit, and cost offset. The authors describe a process by which a pilot demonstration project is being implemented to demonstrate programmatic outcomes with a focus on the following: 1) clinician efficiency, 2) improved health outcomes, and 3) direct revenue generation associated with the inclusion of integrated primary care in a public health care system. The authors subsequently offer specific future directions and commentary regarding financial evaluation in each of these domains.

Access control for electronic patient records.

PubMed

Glagola, M J

1998-01-01

The transition from hardcopy records to electronic records is in the forefront for healthcare today. For healthcare facilities, a major issue is determining who can access patients' medical information and how access to this information can be controlled. There are three components to access control: identification, authentication and authorization. Checking proof of identity is a means of authenticating someone--through a driver's license, passport or their fingerprints. Similar processes are needed in a computer environment, through the use of passwords, one-time passwords or smartcards, encryption and kerberos, and call-back procedures. New in the area of access control are biometric devices, which are hardware/software combinations that digitize a physical characteristic and compare the sample with previously stored samples. Fingerprints, voiceprints and facial features are examples. Their cost is currently prohibitive, but in time, they may become more common. Digital certificates and certification authorities are other means used to authenticate identify. When a system challenges a user's identity at log on, the user provides a certification that tells the system to go to the issuing certification authority and find proof the user's claim is valid. Low-level certifications offer little value for sensitive data, but high-level certification is now being introduced. It requires more specific, detailed information on the applicant. Authorization, the final component of access control, establishes what a specific user can and cannot access. To have effective access control, transaction logging and system monitoring are needed to ensure the various techniques are being used and performing properly.

Young Children in European Countries in the Present Economic and Social Period. Bulletin, 1936, No. 2

ERIC Educational Resources Information Center

Davis, Mary Dabney

1936-01-01

As plans for expansion of the emergency nursery school program were being considered in 1934, opportunity was offered for the author of this bulletin to visit some of the European countries and observe their programs. The Office of Education accepted this voluntary offer and the author, who had been loaned by the Office to the Federal Emergency…

Traditional Master of Business Administration (MBA) versus the MBA with Specialization: A Disconnection between What Business Schools Offer and What Employers Seek

ERIC Educational Resources Information Center

Gupta, Pola B.; Saunders, Paula M.; Smith, Jeremy

2007-01-01

A trend in master of business administration (MBA) programs has been to offer more specializations beyond the traditional broad MBA. In this article, the authors explore the recruitment practices of business and the curricula of MBA programs comparing general MBA degrees with MBA degrees with specialization. The authors empirically examine whether…

Becoming Co-Authors: Toward Sharing Authority in Religious Education

ERIC Educational Resources Information Center

Kim, Hyun-Sook

2009-01-01

This article offers an alternative model, the model of shared authority, to the traditional, authoritarian model for authority and obedience for Religious Education. This model moves away from the authoritarian model of a teacher as the authority and the students as obedient listeners in the direction of a shared authority model in which teachers…

Business marketing: understand what customers value.

PubMed

Anderson, J C; Narus, J A

1998-01-01

How do you define the value of your market offering? Can you measure it? Few suppliers in business markets are able to answer those questions, and yet the ability to pinpoint the value of a product or service for one's customers has never been more important. By creating and using what the authors call customer value models, suppliers are able to figure out exactly what their offerings are worth to customers. Field value assessments--the most commonly used method for building customer value models--call for suppliers to gather data about their customers firsthand whenever possible. Through these assessments, a supplier can build a value model for an individual customer or for a market segment, drawing on data gathered form several customers in that segment. Suppliers can use customer value models to create competitive advantage in several ways. First, they can capitalize on the inevitable variation in customers' requirements by providing flexible market offerings. Second, they can use value models to demonstrate how a new product or service they are offering will provide greater value. Third, they can use their knowledge of how their market offerings specifically deliver value to craft persuasive value propositions. And fourth, they can use value models to provide evidence to customers of their accomplishments. Doing business based on value delivered gives companies the means to get an equitable return for their efforts. Once suppliers truly understand value, they will be able to realize the benefits of measuring and monitoring it for their customers.

Paying Research Participants: Regulatory Uncertainty, Conceptual Confusion, and a Path Forward

PubMed Central

Largent, Emily A; Lynch, Holly Fernandez

2017-01-01

The practice of offering payment to individuals in exchange for their participation in clinical research is widespread and longstanding. Nevertheless, such payment remains the source of substantial debate, in particular about whether or the extent to which offers of payment coerce and/or unduly induce individuals to participate. Yet, the various laws, regulations, and ethical guidelines that govern the conduct of human subjects research offer relatively little in the way of specific guidance regarding what makes a payment offer ethically acceptable—or not. Moreover, there is a lack of definitional agreement regarding what the terms coercion and undue inducement mean in the human subjects research context. It is, therefore, unsurprising that investigators and Institutional Review Boards (IRBs) experience confusion about how to evaluate offers of payment, and lean toward conservative approaches. These trends are exemplified by our pilot data regarding the ways in which some IRB members and investigators (mis)understand the concepts of coercion and undue inducement, as well as the ways in which certain research institutions oversee offers of payment at a local level. This article systematically examines the legal and ethical dimensions of offering payment to research participants. It argues that many concerns about offers of payment to research participants can be attributed to the misguided view that such offers ought to be treated differently than offers of payment in other contexts, a form of “research exceptionalism.” We show that rejection of research exceptionalism with respect to payment helps settle open debates about both how best to define coercion and undue influence, and how to understand the relation between these concepts and offers of payment. We argue for adoption of our preferred definitions, ideally by regulatory authorities, and against the conventional conservatism toward payment of research participants. Instead, we draw attention to the rarely asked, even radical, question: are research participants paid enough? We conclude by arguing that we ought to change the default to favor, rather than encourage suspicion of, offers of payment to research participants. PMID:29249912

The Gift Relationship: Discovering Gift Exchange in Interpersonal Practice.

PubMed

Brown, Christopher Basil

2016-03-01

Encountering the deeper flows of human experience and glimpsing the touch of the divine on the human soul offer guides and companions rich reflective content for their ongoing formation. This is a precious gift which pilgrims constantly place before their companions, though at times it remains 'unwrapped'. Through offering a supervision narrative, this paper provides a phenomenological description of such a gift exchange. © The Author(s) 2016.

Queer Research and Queer Youth

ERIC Educational Resources Information Center

Talburt, Susan

2006-01-01

D'Augelli and Grossman's article offers an eloquent account of a complex longitudinal, interview-based study that surely has the potential to offer nuanced insights into the lives of lesbian, gay, and bisexual (LGB) youth. The authors' copious efforts to recruit, retain, and involve youth while avoiding potential dangers to them offer future…

Waiting in the wings: what can we learn about gene co-option from the diversification of butterfly wing patterns?

PubMed

Jiggins, Chris D; Wallbank, Richard W R; Hanly, Joseph J

2017-02-05

A major challenge is to understand how conserved gene regulatory networks control the wonderful diversity of form that we see among animals and plants. Butterfly wing patterns are an excellent example of this diversity. Butterfly wings form as imaginal discs in the caterpillar and are constructed by a gene regulatory network, much of which is conserved across the holometabolous insects. Recent work in Heliconius butterflies takes advantage of genomic approaches and offers insights into how the diversification of wing patterns is overlaid onto this conserved network. WntA is a patterning morphogen that alters spatial information in the wing. Optix is a transcription factor that acts later in development to paint specific wing regions red. Both of these loci fit the paradigm of conserved protein-coding loci with diverse regulatory elements and developmental roles that have taken on novel derived functions in patterning wings. These discoveries offer insights into the 'Nymphalid Ground Plan', which offers a unifying hypothesis for pattern formation across nymphalid butterflies. These loci also represent 'hotspots' for morphological change that have been targeted repeatedly during evolution. Both convergent and divergent evolution of a great diversity of patterns is controlled by complex alleles at just a few genes. We suggest that evolutionary change has become focused on one or a few genetic loci for two reasons. First, pre-existing complex cis-regulatory loci that already interact with potentially relevant transcription factors are more likely to acquire novel functions in wing patterning. Second, the shape of wing regulatory networks may constrain evolutionary change to one or a few loci. Overall, genomic approaches that have identified wing patterning loci in these butterflies offer broad insight into how gene regulatory networks evolve to produce diversity.This article is part of the themed issue 'Evo-devo in the genomics era, and the origins of morphological diversity'. © 2016 The Author(s).

5 CFR 339.302 - Authority to offer examinations.

Code of Federal Regulations, 2010 CFR

2010-01-01

..., working conditions, or any other benefit or special treatment (including reasonable accommodation or... performance or conduct problem which may require agency action. Reasons for offering an examination must be...

Nonprofit to for-profit conversions by hospitals, health insurers, and health plans.

PubMed

Needleman, J

1999-01-01

Conversion of hospitals, health insurers, and health plans from nonprofit to for-profit ownership has become a focus of national debate. The author examines why nonprofit ownership has been dominant in the US health system and assesses the strength of the argument that nonprofits provide community benefits that would be threatened by for-profit conversion. The author concludes that many of the specific community benefits offered by nonprofits, such as care for the poor, could be maintained or replaced by adequate funding of public programs and that quality and fairness in treatment can be better assured through clear standards of care and adequate monitoring systems. As health care becomes increasingly commercialized, the most difficult parts of nonprofits' historic mission to preserve are the community orientation, leadership role, and innovation that nonprofit hospitals and health plans have provided out of their commitment to a community beyond those to whom they sell services.

Oromucosal film preparations: classification and characterization methods.

PubMed

Preis, Maren; Woertz, Christina; Kleinebudde, Peter; Breitkreutz, Jörg

2013-09-01

Recently, the regulatory authorities have enlarged the variety of 'oromucosal preparations' by buccal films and orodispersible films. Various film preparations have entered the market and pharmacopoeias. Due to the novelty of the official monographs, no standardized characterization methods and quality specifications are included. This review reports the methods of choice to characterize oromucosal film preparations with respect to biorelevant characterization and quality control. Commonly used dissolution tests for other dosage forms are not transferable for films in all cases. Alternatives and guidance on decision, which methods are favorable for film preparations are discussed. Furthermore, issues about requirements for film dosage forms are reflected. Oromucosal film preparations offer a wide spectrum of opportunities. There are a lot of suggestions in the literature on how to control the quality of these innovative products, but no standardized tests are available. Regulatory authorities need to define the standards and quality requirements more precisely.

Commercial Sexual Exploitation of Children and State Child Welfare Systems.

PubMed

Bounds, Dawn; Julion, Wrenetha A; Delaney, Kathleen R

2015-01-01

In several states, commercial sexual exploitation of children (CSEC) is now a reportable child abuse offense. Illinois has taken the lead in tackling the issue and the Illinois experience illuminates valuable lessons. This article delineates the protection, practice, and policy implications that evolve when CSEC falls under a state child welfare system. The specific aims are to (a) discuss CSEC, its victims, risks, harms, and challenges inherent in providing effective care; (b) use Illinois as an exemplar to explicate the consequences and implementation challenges of establishing a state reporting system that frames CSEC as a child welfare issue; (c) recommend strategies for developing effective state reporting models, and (d) demonstrate how nurses are well poised to advocate for victims of human trafficking on both state and national levels. Recommendations for improving the identification of CSEC victims and overcoming challenges to state implementation are offered. © The Author(s) 2015.

Integration-free induced pluripotent stem cells derived from a patient with autosomal recessive Alport syndrome (ARAS).

PubMed

Kuebler, Bernd; Aran, Begoña; Miquel-Serra, Laia; Muñoz, Yolanda; Ars, Elisabet; Bullich, Gemma; Furlano, Monica; Torra, Roser; Marti, Merce; Veiga, Anna; Raya, Angel

2017-12-01

A skin biopsy was obtained from a 25-year-old female patient with autosomal recessive Alport syndrome (ARAS) with the homozygous COL4A3 mutation c.345delG, p.(P166Lfs*37). Dermal fibroblasts were derived and reprogrammed by nucleofection with episomal plasmids carrying OCT3/4, SOX2, KLF4 LIN28, L-MYC and p53shRNA. The generated induced Pluripotent Stem Cell (iPSC) clone AS FiPS1 Ep6F-2 was free of genomically integrated reprogramming genes, had the specific homozygous mutation, a stable karyotype, expressed pluripotency markers and generated embryoid bodies which were differentiated towards the three germ layers in vitro. This iPSC line offers a useful resource to study Alport syndrome pathomechanisms and drug testing. Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.

The influence of journal submission guidelines on authors' reporting of statistics and use of open research practices.

PubMed

Giofrè, David; Cumming, Geoff; Fresc, Luca; Boedker, Ingrid; Tressoldi, Patrizio

2017-01-01

From January 2014, Psychological Science introduced new submission guidelines that encouraged the use of effect sizes, estimation, and meta-analysis (the "new statistics"), required extra detail of methods, and offered badges for use of open science practices. We investigated the use of these practices in empirical articles published by Psychological Science and, for comparison, by the Journal of Experimental Psychology: General, during the period of January 2013 to December 2015. The use of null hypothesis significance testing (NHST) was extremely high at all times and in both journals. In Psychological Science, the use of confidence intervals increased markedly overall, from 28% of articles in 2013 to 70% in 2015, as did the availability of open data (3 to 39%) and open materials (7 to 31%). The other journal showed smaller or much smaller changes. Our findings suggest that journal-specific submission guidelines may encourage desirable changes in authors' practices.

12 CFR 618.8010 - Related services authorization process.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Related services authorization process. 618... PROVISIONS Related Services § 618.8010 Related services authorization process. (a) Authorities. System banks and associations may only offer related services that meet the criteria specified in this regulation...

Interdisciplinary Laboratory Course Facilitating Knowledge Integration, Mutualistic Teaming, and Original Discovery.

PubMed

Full, Robert J; Dudley, Robert; Koehl, M A R; Libby, Thomas; Schwab, Cheryl

2015-11-01

Experiencing the thrill of an original scientific discovery can be transformative to students unsure about becoming a scientist, yet few courses offer authentic research experiences. Increasingly, cutting-edge discoveries require an interdisciplinary approach not offered in current departmental-based courses. Here, we describe a one-semester, learning laboratory course on organismal biomechanics offered at our large research university that enables interdisciplinary teams of students from biology and engineering to grow intellectually, collaborate effectively, and make original discoveries. To attain this goal, we avoid traditional "cookbook" laboratories by training 20 students to use a dozen research stations. Teams of five students rotate to a new station each week where a professor, graduate student, and/or team member assists in the use of equipment, guides students through stages of critical thinking, encourages interdisciplinary collaboration, and moves them toward authentic discovery. Weekly discussion sections that involve the entire class offer exchange of discipline-specific knowledge, advice on experimental design, methods of collecting and analyzing data, a statistics primer, and best practices for writing and presenting scientific papers. The building of skills in concert with weekly guided inquiry facilitates original discovery via a final research project that can be presented at a national meeting or published in a scientific journal. © The Author 2015. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

Tobacco, youth, and sports.

PubMed

Epps, R P; Lynn, W R; Manley, M W

1998-10-01

Cigarette smoking constitutes the single largest threat to the health and longevity of American youth. Each year, almost 400,000 people die prematurely from tobacco-related diseases. Moreover, 90% of adult smokers began using tobacco before their eighteenth birthday, and each day 3,000 children and adolescents begin smoking. Smokeless tobacco use is less prevalent than cigarette smoking but has similar deleterious health effects and is often also glamorized by sports figures. This article examines the relationship between tobacco and sports and offers specific steps that physicians (specifically orthopedic surgeons and sports medicine physicians, who interact with athletes at sporting events and in schools as well as at the clinic) can take to help prevent or minimize tobacco use. Although sports have been used by the tobacco industry to promote tobacco products to young people, the authors suggest new ways to prevent its success.

An Integrated Conceptual Framework for the Development of Asian American Children and Youth.

PubMed

Mistry, Jayanthi; Li, Jin; Yoshikawa, Hirokazu; Tseng, Vivian; Tirrell, Jonathan; Kiang, Lisa; Mistry, Rashmita; Wang, Yijie

2016-07-01

The diversity of circumstances and developmental outcomes among Asian American children and youth poses a challenge for scholars interested in Asian American child development. This article addresses the challenge by offering an integrated conceptual framework based on three broad questions: (a) What are theory-predicated specifications of contexts that are pertinent for the development of Asian American children? (b) What are the domains of development and socialization that are particularly relevant? (c) How can culture as meaning-making processes be integrated in conceptualizations of development? The heuristic value of the conceptual model is illustrated by research on Asian American children and youth that examines the interconnected nature of specific features of context, pertinent aspects of development, and interpretive processes. © 2016 The Authors. Child Development © 2016 Society for Research in Child Development, Inc.

[Needs-based offers and gender-specific aspects in nursing homes : Results of a representative survey among directors of nursing homes].

PubMed

Teubner, Christian; Sulmann, Daniela; Lahmann, Nils; Suhr, Ralf

2016-12-01

Nursing and care that consider individual and biographically shaped impressions requires, among other things sensitivity for the specific needs of persons in need of care. A representative survey was conducted among directors of nursing homes to provide information about the importance of gender-specific aspects in nursing. In a written survey 516 directors of German resident care facilities were interviewed about their attitudes and perceptions regarding the subject, about information on general and gender-specific offers and about demographic information on the management of nursing homes. Activities specifically considering the needs of men and women (gender-specific 43.1 %) are not widespread in the nursing homes surveyed. Most respondents reasoned that there was no demand for such offers (57.1 %) or that they are dispensable due to the composition of residents (47.6 %). Of the respondents 36.4 % saw specific needs more with women than with men (18.4 %). Nevertheless, the need for male-specific activities is given a relatively high priority. The consideration of gender aspects in the planning of care processes (57.0 %) and the regular reflection of gender issues (20.7 %) are strongly correlated with the existence of gender-specific offers, while structural factors, such as the institution size and the education of nursing home directors are not. Currently, gender-specific activity offers in nursing facilities are not widespread. Existing offers are mostly based on traditional gender stereotypes; therefore, it would be desirable if the diversity in the reality of life and the individual needs of women and men would be recognized.

The role of direct-to-consumer pharmaceutical advertisements and individual differences in getting people to talk to physicians.

PubMed

Krezmien, Elyse; Wanzer, Melissa Bekelja; Servoss, Timothy; LaBelle, Sara

2011-09-01

In this study, 384 respondents provided quantitative and descriptive information about direct-to-consumer (DTC) pharmaceutical advertisements and factors related to message reception and drug adoption. The authors applied M. Booth-Butterfield's ( 2008 ) Standard Model to explain how DTC advertising is used in getting individuals to talk to their doctors about pharmaceutical drugs. The researchers predicted that individuals who talked with their physicians about a pharmaceutical drug (referred to as talkers) would differ from those who did not talk with their physicians (referred to as nontalkers) in a number of meaningful ways. Findings from this data set indicate that individuals who talked with their physician about a specific medication were more likely to be female, older, higher in need for cognition, and reported higher physician satisfaction. Total number of channels (TV, radio, newspaper, magazines, and the Internet) was negatively associated with talking to a physician about a specific medication, as was exposure to DTC advertisement on television. The authors offer explanations for these findings along with descriptive accounts of how talkers and nontalkers differed in their recall of DTC advertisement information. Copyright © Taylor & Francis Group, LLC

Future directions for beam-foil spectroscopy

NASA Technical Reports Server (NTRS)

Bashkin, S.

1976-01-01

The beam-foil source has proved to be so useful for the study of atomic energy levels that it is almost trivial to propose a variety of new experiments involving new elements, higher energies, a broader wavelength range, shorter time intervals, pulsed beams, different targets, and new configurations in geometry or external fields. However, what is perhaps not so trivial is to propose experiments for which there is a specific purpose, experiments from which a novel kind of information might be expected. It is from this latter point of view that the author shall talk about experiments which seem to offer unusual opportunities to learn new things about atoms.

NASA/DoD Aerospace Knowledge Diffusion Research Project. XXV - The impact of language and culture on technical communication in Japan

NASA Technical Reports Server (NTRS)

Kohl, John R.; Barclay, Rebecca O.; Pinelli, Thomas E.; Keene, Michael L.; Kennedy, John M.

1993-01-01

One of the most significant developments in the field of technical communication during the 1980s and 1990s has been a growing interest in international technical communication, including technical communication in Japan. This article provides insights into aspects of the Japanese language and culture that affect Japanese technical communication practices. The authors then use these insights to interpret and report the results of a survey of Japanese aerospace engineers and scientists concerning the kinds of communication products they produce, the kinds they use, and the specific recommendations they would offer to designers of academic programs in technical communication.

Alcohol expectancy multiaxial assessment: a memory network-based approach.

PubMed

Goldman, Mark S; Darkes, Jack

2004-03-01

Despite several decades of activity, alcohol expectancy research has yet to merge measurement approaches with developing memory theory. This article offers an expectancy assessment approach built on a conceptualization of expectancy as an information processing network. The authors began with multidimensional scaling models of expectancy space, which served as heuristics to suggest confirmatory factor analytic dimensional models for entry into covariance structure predictive models. It is argued that this approach permits a relatively thorough assessment of the broad range of potential expectancy dimensions in a format that is very flexible in terms of instrument length and specificity versus breadth of focus. ((c) 2004 APA, all rights reserved)

Formation of power management strategy at the industrial enterprises

NASA Astrophysics Data System (ADS)

Akimova, Elena

2017-10-01

The article is dedicated to energy efficiency problems. The main recommendations about the development of the system of strategic power management at the industrial enterprise offered in the research include a number of the principles, aimed at the increase of the importance of human resources in information-and-analytical and innovative functions of power management. According to the results of the current situation analyses, the author suggests using some specific indicators of human resources, as they can contribute to the energy efficiency formation. The system of standardization is considered to be the basis for the implementation of strategic power management at the enterprises.

Generation and analyses of human synthetic antibody libraries and their application for protein microarrays.

PubMed

Säll, Anna; Walle, Maria; Wingren, Christer; Müller, Susanne; Nyman, Tomas; Vala, Andrea; Ohlin, Mats; Borrebaeck, Carl A K; Persson, Helena

2016-10-01

Antibody-based proteomics offers distinct advantages in the analysis of complex samples for discovery and validation of biomarkers associated with disease. However, its large-scale implementation requires tools and technologies that allow development of suitable antibody or antibody fragments in a high-throughput manner. To address this we designed and constructed two human synthetic antibody fragment (scFv) libraries denoted HelL-11 and HelL-13. By the use of phage display technology, in total 466 unique scFv antibodies specific for 114 different antigens were generated. The specificities of these antibodies were analyzed in a variety of immunochemical assays and a subset was further evaluated for functionality in protein microarray applications. This high-throughput approach demonstrates the ability to rapidly generate a wealth of reagents not only for proteome research, but potentially also for diagnostics and therapeutics. In addition, this work provides a great example on how a synthetic approach can be used to optimize library designs. By having precise control of the diversity introduced into the antigen-binding sites, synthetic libraries offer increased understanding of how different diversity contributes to antibody binding reactivity and stability, thereby providing the key to future library optimization. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Striving for Gender Equity in Academic Medicine Careers: A Call to Action

PubMed Central

Bates, Carol; Gordon, Lynn; Travis, Elizabeth; Chatterjee, Archana; Chaudron, Linda; Fivush, Barbara; Gulati, Martha; Jagsi, Reshma; Sharma, Poonam; Gillis, Marin; Ganetzky, Rebecca; Grover, Amelia; Lautenberger, Diana; Moses, Ashleigh

2018-01-01

Women represent approximately half of students entering medical schools and more than half of those entering PhD programs. When advancing through the academic and professional fields, however, women continually face barriers that men do not. In this Commentary, the authors offer ideas for coordinating the efforts of organizations, academic institutions, and leaders throughout the scientific and medical professions to reduce barriers that result in inequities and, instead, strive for gender parity. Specific areas of focus outlined by the authors include facilitating women’s access to formal and informal professional networks, acknowledging and addressing the gender pay gap as well as the lack of research funding awarded to women in the field, and updating workplace policies that have not evolved to accommodate women’s lifestyles. As academic institutions seek access to top talent and the means to develop those individuals capable of generating the change medicine and science needs, the authors urge leaders and change agents within academic medicine to address the systemic barriers to gender equity that impede us from achieving the mission to improve the health of all. PMID:27332868

Striving for Gender Equity in Academic Medicine Careers: A Call to Action.

PubMed

Bates, Carol; Gordon, Lynn; Travis, Elizabeth; Chatterjee, Archana; Chaudron, Linda; Fivush, Barbara; Gulati, Martha; Jagsi, Reshma; Sharma, Poonam; Gillis, Marin; Ganetzky, Rebecca; Grover, Amelia; Lautenberger, Diana; Moses, Ashleigh

2016-08-01

Women represent approximately half of students entering medical schools and more than half of those entering PhD programs. When advancing through the academic and professional fields, however, women continually face barriers that men do not. In this Commentary, the authors offer ideas for coordinating the efforts of organizations, academic institutions, and leaders throughout the scientific and medical professions to reduce barriers that result in inequities and, instead, strive for gender parity. Specific areas of focus outlined by the authors include facilitating women's access to formal and informal professional networks, acknowledging and addressing the gender pay gap as well as the lack of research funding awarded to women in the field, and updating workplace policies that have not evolved to accommodate women's lifestyles. As academic institutions seek access to top talent and the means to develop those individuals capable of generating the change medicine and science needs, the authors urge leaders and change agents within academic medicine to address the systemic barriers to gender equity that impede us from achieving the mission to improve the health of all.

College health professionals and academic librarians: collaboration for student health.

PubMed

Hallyburton, Ann; Kolenbrander, Nancy; Robertson, Carolyn

2008-01-01

College health professionals must find new ways of educating students on finding and evaluating consumer health information, specifically in the online environment. Librarians are trained as information professionals; however, librarians at general academic libraries are not taking a lead role in providing consumer health information. The authors' purpose in this research was to determine the health information resource needs of college and university students and provide a model for collaboration between college health professionals and academic librarians. The authors compared data from a national survey on college health (N = 54,111) with their own results from a survey of general academic librarians (N = 17) to create recommendations for synching students' reported health information needs with librarians' resources. Although the Internet was students' second most-often consulted health information source, they ranked the believability of online health information above only television. In the librarian survey, although 12 respondents indicated that health information provision is a library's responsibility, the majority (n = 11) believed their library's consumer health outreach to be passive. The authors offer recommendations for partnerships between college healthcare professionals and academic librarians to better provide this information to students.

47 CFR 76.983 - Discrimination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... local franchising authority may prohibit a cable operator from offering reasonable discounts to senior... Federal agency, state, or local franchising authority from requiring and regulating the reception of cable...

Dnd Is a Critical Specifier of Primordial Germ Cells in the Medaka Fish.

PubMed

Hong, Ni; Li, Mingyou; Yuan, Yongming; Wang, Tiansu; Yi, Meisheng; Xu, Hongyan; Zeng, Huaqiang; Song, Jianxing; Hong, Yunhan

2016-03-08

Primordial germ cell (PGC) specification occurs early in development. PGC specifiers have been identified in Drosophila, mouse, and human but remained elusive in most animals. Here we identify the RNA-binding protein Dnd as a critical PGC specifier in the medaka fish (Oryzias latipes). Dnd depletion specifically abolished PGCs, and its overexpression boosted PGCs. We established a single-cell culture procedure enabling lineage tracing in vitro. We show that individual blastomeres from cleavage embryos at the 32- and 64-cell stages are capable of PGC production in culture. Importantly, Dnd overexpression increases PGCs via increasing PGC precursors. Strikingly, dnd RNA forms prominent particles that segregate asymmetrically. Dnd concentrates in germ plasm and stabilizes germ plasm RNA. Therefore, Dnd is a critical specifier of fish PGCs and utilizes particle partition as a previously unidentified mechanism for asymmetric segregation. These findings offer insights into PGC specification and manipulation in medaka as a lower vertebrate model. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

IBM Watson: How Cognitive Computing Can Be Applied to Big Data Challenges in Life Sciences Research.

PubMed

Chen, Ying; Elenee Argentinis, J D; Weber, Griff

2016-04-01

Life sciences researchers are under pressure to innovate faster than ever. Big data offer the promise of unlocking novel insights and accelerating breakthroughs. Ironically, although more data are available than ever, only a fraction is being integrated, understood, and analyzed. The challenge lies in harnessing volumes of data, integrating the data from hundreds of sources, and understanding their various formats. New technologies such as cognitive computing offer promise for addressing this challenge because cognitive solutions are specifically designed to integrate and analyze big datasets. Cognitive solutions can understand different types of data such as lab values in a structured database or the text of a scientific publication. Cognitive solutions are trained to understand technical, industry-specific content and use advanced reasoning, predictive modeling, and machine learning techniques to advance research faster. Watson, a cognitive computing technology, has been configured to support life sciences research. This version of Watson includes medical literature, patents, genomics, and chemical and pharmacological data that researchers would typically use in their work. Watson has also been developed with specific comprehension of scientific terminology so it can make novel connections in millions of pages of text. Watson has been applied to a few pilot studies in the areas of drug target identification and drug repurposing. The pilot results suggest that Watson can accelerate identification of novel drug candidates and novel drug targets by harnessing the potential of big data. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

Automated System Of Monitoring Of The Physical Condition Of The Staff Of The Enterprise

NASA Astrophysics Data System (ADS)

Pilipenko, A.

2017-01-01

In the work the author solves an important applied problem of increasing of safety of engineering procedures and production using technologies of monitoring of a condition of employees. The author offers a work algorithm, structural and basic electric schemes of system of collection of data of employee’s condition of the enterprise and some parameters of the surrounding environment. In the article the author offers an approach to increasing of efficiency of acceptance of management decisions at the enterprise at the expense of the prompt analysis of information about employee’s condition and productivity of his work and also about various parameters influencing these factors.

A Program for Alcoholism Nursing

ERIC Educational Resources Information Center

Heinemann, M. Edith; Estes, Nada J.

1974-01-01

This specialized program offers both undergraduate and graduate students a variety of study and learning experiences. It offers three modes of study to provide scope and depth of understanding of alcoholism: substantive, integrated, and independent study. (Author/MW)

Home oximetry to screen for obstructive sleep apnoea in Down syndrome.

PubMed

Hill, Catherine M; Elphick, Heather E; Farquhar, Michael; Gringras, Paul; Pickering, Ruth M; Kingshott, Ruth N; Martin, Jane; Reynolds, Janine; Joyce, Anna; Gavlak, Johanna C; Evans, Hazel J

2018-05-14

Children with Down syndrome are at high risk of obstructive sleep apnoea (OSA) and screening is recommended. Diagnosis of OSA should be confirmed with multichannel sleep studies. We aimed to determine whether home pulse oximetry (HPO) discriminates children at high risk of OSA, who need further diagnostic multichannel sleep studies. Cross-sectional prospective study in a training sample recruited through three UK centres. Validation sample used single-centre retrospective analysis of clinical data. Children with Down syndrome aged 0.5-6 years. Diagnostic multichannel sleep study and HPO. Sensitivity and specificity of HPO to predict moderate-to-severe OSA. 161/202 children with Down syndrome met quality criteria for inclusion and 25 had OSA. In this training sample, the best HPO parameter predictors of OSA were the delta 12 s index >0.555 (sensitivity 92%, specificity 65%) and 3% oxyhaemoglobin (SpO 2 ) desaturation index (3% ODI)>6.15 dips/hour (sensitivity 92%, specificity 63%). Combining variables (delta 12 s index, 3% ODI, mean and minimum SpO 2 ) achieved sensitivity of 96% but reduced specificity to 52%. All predictors retained or improved sensitivity in a clinical validation sample of 50 children with variable loss of specificity, best overall was the delta 12 s index, a measure of baseline SpO 2 variability (sensitivity 92%; specificity 63%). HPO screening could halve the number of children with Down syndrome needing multichannel sleep studies and reduce the burden on children, families and health services alike. This approach offers a practical universal screening approach for OSA in Down syndrome that is accessible to the non-specialist paediatrician. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

48 CFR 50.205-3 - Authorization of offers contingent upon SAFETY Act designation or certification before contract...

Code of Federal Regulations, 2011 CFR

2011-10-01

...— (i) For offers contingent upon SAFETY Act designation, a pre-qualification designation notice or a block designation; or (ii) For offers contingent upon SAFETY Act certification, a block certification... contingent upon SAFETY Act designation or certification before contract award. 50.205-3 Section 50.205-3...

Marketing Digital Offerings Is Different: Strategies for Teaching about Digital Offerings in the Marketing Classroom

ERIC Educational Resources Information Center

Roberts, Scott D.; Micken, Kathleen S.

2015-01-01

Digital offerings represent different challenges for marketers than do traditional goods and services. After reviewing the literature, the authors suggest ways that the marketing of digital goods and services might be better presented to and better understood by students. The well-known four challenges of services marketing model (e.g.,…

Digital technology in respiratory diseases: Promises, (no) panacea and time for a new paradigm.

PubMed

Pinnock, Hilary; McKinstry, Brian

2016-05-01

In a world where digital technology has revolutionized the way we work, shop and manage our finances it is unsurprising that digital systems are suggested as potential solutions to delivering clinically and cost-effective care for an aging population with one or more long-term conditions. However, recent evidence suggesting that telehealth may not be quite the panacea that was promised, has led to discussions on the mechanisms and role of digital technology in respiratory care. Implementation in rural and remote settings offers significant benefits in terms of convenient access to care, but is contingent on technical and organizational infrastructure. Telemonitoring systems rely on algorithms to detect deterioration and trigger alerts; machine learning may enable telemonitoring of the future to develop personalized systems that are sensitive to clinical status whilst reducing false alerts. By providing access to information, offering convenient and flexible modes of communication and enabling the transfer of monitoring data to support professional assessment, telehealth can support self-management. At present, all too often, expensive 'off the shelf' systems are purchased and given to clinicians to use. It is time for the paradigm to shift. As clinicians we should identify the specific challenges we face in delivering care, and expect flexible systems that can be customized to individual patients' requirements and adapted to our diverse healthcare contexts. © The Author(s) 2016.

Personalized gene silencing therapeutics for Huntington disease.

PubMed

Kay, C; Skotte, N H; Southwell, A L; Hayden, M R

2014-07-01

Gene silencing offers a novel therapeutic strategy for dominant genetic disorders. In specific diseases, selective silencing of only one copy of a gene may be advantageous over non-selective silencing of both copies. Huntington disease (HD) is an autosomal dominant disorder caused by an expanded CAG trinucleotide repeat in the Huntingtin gene (HTT). Silencing both expanded and normal copies of HTT may be therapeutically beneficial, but preservation of normal HTT expression is preferred. Allele-specific methods can selectively silence the mutant HTT transcript by targeting either the expanded CAG repeat or single nucleotide polymorphisms (SNPs) in linkage disequilibrium with the expansion. Both approaches require personalized treatment strategies based on patient genotypes. We compare the prospect of safe treatment of HD by CAG- and SNP-specific silencing approaches and review HD population genetics used to guide target identification in the patient population. Clinical implementation of allele-specific HTT silencing faces challenges common to personalized genetic medicine, requiring novel solutions from clinical scientists and regulatory authorities. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

12 CFR 250.142 - Meaning of “obligor or maker” in determining limitation on securities investments by member State...

Code of Federal Regulations, 2013 CFR

2013-01-01

... investments by member State banks. (a) From time to time the New York State Dormitory Authority offers issues... of the New York Dormitory Authority Act (N.Y. Public Authorities Law sections 1675-1690), the... the Dormitory Authority. (12 U.S.C. 24, 335) ...

12 CFR 250.142 - Meaning of “obligor or maker” in determining limitation on securities investments by member State...

Code of Federal Regulations, 2012 CFR

2012-01-01

... investments by member State banks. (a) From time to time the New York State Dormitory Authority offers issues... of the New York Dormitory Authority Act (N.Y. Public Authorities Law sections 1675-1690), the... the Dormitory Authority. (12 U.S.C. 24, 335) ...

12 CFR 250.142 - Meaning of “obligor or maker” in determining limitation on securities investments by member State...

Code of Federal Regulations, 2014 CFR

2014-01-01

... investments by member State banks. (a) From time to time the New York State Dormitory Authority offers issues... of the New York Dormitory Authority Act (N.Y. Public Authorities Law sections 1675-1690), the... the Dormitory Authority. (12 U.S.C. 24, 335) ...

12 CFR 250.142 - Meaning of “obligor or maker” in determining limitation on securities investments by member State...

Code of Federal Regulations, 2011 CFR

2011-01-01

... member State banks. (a) From time to time the New York State Dormitory Authority offers issues of bonds... of the New York Dormitory Authority Act (N.Y. Public Authorities Law sections 1675-1690), the... the Dormitory Authority. (12 U.S.C. 24, 335) ...

77 FR 38698 - Self-Regulatory Organizations; Financial Industry Regulatory Authority Inc.; Notice of Filing and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-28

... participation programs (``DPPs'') and real estate investment trusts (``REITs''), but generally exclude public offerings of seasoned issuers that are not broker- dealers or their affiliates and offerings of investment...

Biological Studies in Art

ERIC Educational Resources Information Center

Karan, Theodora

1978-01-01

The Biological Studies in Art program offers students at the high school level an unusual opportunity to prepare for a career in biological illustration. This field offers opportunities for employment in museums, publishing houses, and other similar settings. (Author/BB)

Report of Sugar-Sweetened Beverages Offered in Pennsylvania Childcare Centers.

PubMed

Lutzkanin, Kristen M; Myers, Abigail K; Schaefer, Eric W; Sekhar, Deepa L

2016-06-01

The study objective was to quantify sugar-sweetened beverage (SSB) offerings to children in Pennsylvania (PA) childcare centers and determine whether this information is communicated to parents. In October 2014, a SurveyMonkey link was sent to 4461 PA childcare centers. The 518 respondents represented 88% of PA counties. 279 centers (54%) serve SSBs. 330 (65%) of childcare centers provide parents a report of their child's daily intake. Of 185 centers serving SSBs and providing a daily intake report, 91% include SSB consumption. In total, 38% of centers (103/272) offer but do not report SSB consumption. In 96% of centers, parents may request their child not receive SSBs. In conclusion, though more than half of PA childcare centers surveyed offer SSBs, those providing daily intake reports usually include SSB consumption. Requiring daily intake reports may be a strategy to increase parental awareness of items consumed outside the home. © The Author(s) 2015.

Advice offered by practitioners of complementary/ alternative medicine: an important ethical issue.

PubMed

Ernst, E

2009-12-01

The current popularity of complementary/alternative medicine (CAM) generates many challenges to medical ethics. The one discussed here is the advice offered by CAM practitioners. Using selected examples, the author tries to demonstrate that some of the advice issued through the popular media or provided by acupuncturists, chiropractors, herbalists, homeopaths, pharmacists, and doctors is misleading or dangerous. This, the author argues, can impinge on the main principle of medical ethics: beneficence, nonmaleficence, and autonomy. We should work toward correcting this deplorable situation.

77 FR 52711 - Sabine River Authority of Texas and Sabine River Authority, State of Louisiana; Notice of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-30

..., containing two vertical Kaplan turbines with an authorized installed capacity of 81 megawatts (MW); (5) a 220... construct a 1.3-MW minimum flow turbine-generator at the project spillway. The offer of settlement involves...

Social skills interventions for the autism spectrum: essential ingredients and a model curriculum.

PubMed

Krasny, Lori; Williams, Brenda J; Provencal, Sherri; Ozonoff, Sally

2003-01-01

This article outlines the ingredients the authors feel are critical to making social skills interventions successful for children with autism spectrum disorders. The authors described basic principles for teaching social skills that capitalize on the strengths of such children, while specifically addressing their deficits. The authors applied these widely used principles to group social skills intervention. In particular, social skills groups for children with ASD need to break down complex social behaviors into concrete steps and rules that can be memorized and practiced in a variety of settings. Abstract concepts must be made concrete through a variety of visual, tangible, "hands-on" activities that make socialization fun. Visual structure and predictable routines are essential. Also critical to the success of social skills intervention are instruction and activities that provide necessary support for the language abilities of the participants. A variety of learning opportunities must be used to teach the goals and skills most relevant to children with ASD. These skills must be integrated as intervention progresses. Furthermore, interactions that require the children to focus on peers create a positive social group culture. Within this culture and environment, self-awareness and positive self-esteem can be fostered. A behavior plan that specifies individual goals for group members and a specific system for delivering rewards should be included. Other important ingredients include generalization, which is encouraged through community outings, skill practice in more naturalistic settings, and collaboration with parents and teachers to work on skills outside the group intervention. Weekly therapy does little to change basic deficits of ASD unless there is daily practice and reinforcement of the skills being learned in more natural situations. The authors hope that outlining these principles and specific techniques will encourage more clinicians to offer social skills groups and thus increase their availability around the nation and world. Continued research and treatment for social skills is necessary to provide much needed empiric evidence to determine effectiveness of such interventions.

Leadership for health improvement--implementation and evaluation.

PubMed

Carr, Susan M; Carr, Sue; Lhussier, Monique; Reynolds, Joanna; Hunter, David J; Hannaway, Catherine

2009-01-01

The purpose of this paper is to present a co-authored reflection on the health improvement leadership development programme and the key evaluation messages derived from piloting in an English National Health Service region. It highlights the specific attributes of this approach to health improvement leadership development and clarifies health improvement development issues. Appreciative inquiry and soft systems methodology are combined in an evaluation approach designed to capture individual as well as organisation learning and how it impacts on leadership in specific contexts. The evaluation exposes the health improvement leadership needs of a multi-organisation cohort, offers some explanations for successful achievement of learning needs while also exposing of the challenges and paradoxes faced in this endeavour. There are limited reported templates of how to develop leadership for health improvement. This paper details a whole systems approach, acknowledging the impact of context on leadership and an approach to evaluating such complex initiatives.

Endoscopic Management of Benign Esophageal Strictures.

PubMed

Ravich, William J

2017-08-24

This paper presents the author's approach to esophageal dilation. It offers a tailored approach to the application of dilation to specific types of esophageal stenotic lesions. In patients with inflammatory stricture, recent studies confirm the importance of treating the underlying inflammatory condition in order to decrease the rate of recurrence. The paper reviews some of the novel techniques that have been suggested for the treatment of refractory benign esophageal strictures, including incisional therapy, stenting, or the injection steroids or antifibrotic agents. The endoscopist who treats esophageal strictures must be familiar with the tools of the dilation and how they are best applied to specific types of stenotic lesions. If inflammation is present, effective management requires treatment of the inflammatory process in addition to mechanical dilation of the stenotic lesion. Controlled trials of novel approaches to treatment of refractory benign esophageal strictures are limited and will be necessary to determine efficacy.

Outplacement Services for Displaced Employees: Attitudes of Human Resource Managers Based on Differences in Internal and External Delivery

ERIC Educational Resources Information Center

Kilcrease, Kelly M.

2013-01-01

The results from a survey of 238 human resources executives from organizations that offer outplacement counseling (OPC) internally and 168 that offer it externally suggest that internal OPC delivery is inferior to external OPC delivery. The author found that most internal OPC organizations did not offer the 13 traditional OPC services, even when…

75 FR 12296 - Prohibited Transaction Exemptions and Grant of Individual Exemptions Involving: 2010-04, JPMorgan...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-15

.... App. 1 (1996), transferred the authority of the Secretary of the Treasury to issue exemptions of the... Offer may be made by Goldman after Goldman has determined that such purchase is in the best interest of... purchase under the Offer; (2) The background of the Offer; (3) The methods and timing by which Plans may...

All About School People Who Accept "Gifts' from School Suppliers and Manufacturers

ERIC Educational Resources Information Center

Monks, Robert

1974-01-01

A survey reveals that the school officials all over the country are being offered gifts by people who do business with schools. Most gift offering and accepting is done subtly and probably unconsciously. (Author/WM)

Isolated Apprenticeship Program. Final Report on Phase 2.

ERIC Educational Resources Information Center

New Mexico State Dept. of Education, Santa Fe.

A study is reported on the isolated correspondence courses offered in vocational areas by the New Mexico State Department of Vocational Education. Some courses which were offered were appliance servicing, automobile mechanics, cabinet making, meatcutting, refrigeration, and welding. (Author)

Pharmaceutical Education in Nigeria.

ERIC Educational Resources Information Center

Oyegbile, F. Rachel

1988-01-01

Nigeria has six pharmacy schools, most offering graduate programs. The undergraduate program is being expanded from four to five years. Although behavioral and clinical sciences are offered, emphasis is on the pharmaceutical sciences. Overall, pharmaceutical education is oriented toward hospice practice. (Author/MSE)

If You Feed Them, Will They Come? The Use of Social Marketing to Increase Interest in Attending a College Alcohol Program

PubMed Central

Palmer, Rebekka S.; Kilmer, Jason R.; Larimer, Mary E.

2010-01-01

The authors used social marketing to design and test advertisement components aimed at increasing students’ interest in attending an alcohol program focused on reaching students who drink heavily, although the authors offered no such program. Participants were undergraduate students in introductory psychology courses (N = 551). Questionnaires included measures assessing demographic information, alcohol use and negative consequences, and interest in attending an alcohol program in response to exposure to 1 of 12 systematically varied advertisements. The authors found that approximately 20% of participants across all ad types indicated some level of interest in attending the alcohol program. Students who use alcohol reported more interest in attending when an informational message was used. Of the participants offered food, 41.9% indicated the food offered in the advertisement impacted their interest in attending. Results suggest market segmentation plays a role in developing effective advertisements to recruit different groups of students based on their reported drinking behavior. PMID:16889315

If you feed them, will they come? The use of social marketing to increase interest in attending a college alcohol program.

PubMed

Palmer, Rebekka S; Kilmer, Jason R; Larimer, Mary E

2006-01-01

The authors used social marketing to design and test advertisement components aimed at increasing students' interest in attending an alcohol program focused on reaching students who drink heavily, although the authors offered no such program. Participants were undergraduate students in introductory psychology courses (N = 551). Questionnaires included measures assessing demographic information, alcohol use and negative consequences, and interest in attending an alcohol program in response to exposure to 1 of 12 systematically varied advertisements. The authors found that approximately 20% of participants across all ad types indicated some level of interest in attending the alcohol program. Students who use alcohol reported more interest in attending when an informational message was used. Of the participants offered food, 41.9% indicated the food offered in the advertisement impacted their interest in attending. Results suggest market segmentation plays a role in developing effective advertisements to recruit different groups of students based on their reported drinking behavior.

Review of Leaving it at the office.

PubMed

Hays, Kate F

2008-06-01

Reviews the book, Leaving it at the office by John C. Norcross and James D. Guy (2007). This book is filled with compassionate fervor and recognition of the satisfactions of our professional lives. Twelve central elements to therapist self-care form the base for the 12 chapters of the book. Describing themselves as "integrative psychotherapists," Norcross and Guy begin from the perspective of seeing the person of the psychotherapist as a valued human being. They encourage us to refocus on the rewards of our profession, while recognizing its hazards. Body, mind, and soul or spirit are each given their due: attending to activity, awareness and restructuring of our own cognitions (regardless of theoretical perspective), engaging in personal therapy of one kind or another, and cultivating spirituality or mission, creativity and growth. Each chapter sets out information that is described as a field guide rather than an instructional manual, a "curious mix of 'how to,' 'you should,' and 'chill-out.'" Information is culled from many types of sources: the authors' own research and that of a wide variety of others' with respect to self-care; workshops that the authors have offered regarding self-care; and clinical wisdom derived in part from interviews with master clinicians. Chapters are structured into sections focused on self-care both at the office and away from the office. (Yes, sometimes our not-great self-care extends outside of the office setting.) A summary self-care list ends each chapter, one that could serve as a wellness reminder or checklist for any individual. Further, the authors offer specific recommended reading at the end of each chapter, as well as an extensive full reference section at the end of the book. (PsycINFO Database Record (c) 2010 APA, all rights reserved).

Getting to Know Us: or, the Rewards and Problems of Outreach and Affiliation Programs.

ERIC Educational Resources Information Center

Jankowski, Theodora A.

Outreach and affiliation efforts undertaken by Utica College, an independently administered branch of Syracuse University, are discussed. The following general guidelines are offered: (1) contract for a specific price for any given offering so that fixed and variable costs will be covered; (2) offer courses that lead to a specific goal such as a…

Medical humanities and their discontents: definitions, critiques, and implications.

PubMed

Shapiro, Johanna; Coulehan, Jack; Wear, Delese; Montello, Martha

2009-02-01

The humanities offer great potential for enhancing professional and humanistic development in medical education. Yet, although many students report benefit from exposure to the humanities in their medical education, they also offer consistent complaints and skepticism. The authors offer a pedagogical definition of the medical humanities, linking it to medicine as a practice profession. They then explore three student critiques of medical humanities curricula: (1) the content critique, examining issues of perceived relevance and intellectual bait-and-switch, (2) the teaching critique, which examines instructor trustworthiness and perceived personal intrusiveness, and (3) the structural/placement critique, or how and when medical humanities appear in the curriculum. Next, ways are suggested to tailor medical humanities to better acknowledge and reframe the needs of medical students. These include ongoing cross-disciplinary reflective practices in which intellectual tools of the humanities are incorporated into educational activities to help students examine and, at times, contest the process, values, and goals of medical practice. This systematic, pervasive reflection will organically lead to meaningful contributions from the medical humanities in three specific areas of great interest to medical educators: professionalism, "narrativity," and educational competencies. Regarding pedagogy, the implications of this approach are an integrated required curriculum and innovative concepts such as "applied humanities scholars." In turn, systematic integration of humanities perspectives and ways of thinking into clinical training will usefully expand the range of metaphors and narratives available to reflect on medical practice and offer possibilities for deepening and strengthening professional education.

"A battle not man's but God's": origins of the American temperance crusade in the struggle for religious authority.

PubMed

Schmidt, L A

1995-01-01

Major theories of the origins of American temperance have emphasized materialist explanations without taking seriously enough the independent role of ideas--and, in particular, religious ideas--in stimulating the reform. This article develops a new interpretation, focusing on the religious origins of temperance in a "crisis of contested authority" that befell the Protestant denominations descended from Puritanism during the early years of the 19th century. One outgrowth of the crisis over the authority of traditional religious ideas was a new theology focused on religious salvation through the suppression of vice. This new religious ideology provided a core of beliefs and powerful justification for organizing a public crusade to "exterminate" vice, and one that for ideological reasons ultimately narrowed its focus to the specific vice of intemperance. The crusade against vice in the early republic offered clergymen a "solution" to their problems of contested authority by providing new strategies and an organizational base of voluntary societies for carrying out what they perceived to be their sacred duties: winning souls to God, guarding collective salvation and leveraging government to promote obedience to religious prohibitions on vice. At least initially, temperance was part of a new kind of effort to assert the authority of religious ideas in the public sphere, and to regroup religious forces under auspices outside the church.

Family and Leisure: A Set of Contradictions

ERIC Educational Resources Information Center

Carisse, Colette B.

1975-01-01

The author examines differing concepts of time-space and how these influence the way families use their leisure. A typology of family leisure styles is presented offering several normal and pathological alternatives. (Author)

The Specification of Causal Models with Tetrad IV: A Review

ERIC Educational Resources Information Center

Landsheer, J. A.

2010-01-01

Tetrad IV is a program designed for the specification of causal models. It is specifically designed to search for causal relations, but also offers the possibility to estimate the parameters of a structural equation model. It offers a remarkable graphical user interface, which facilitates building, evaluating, and searching for causal models. The…

50 CFR 20.91 - Commercial use of feathers.

Code of Federal Regulations, 2012 CFR

2012-10-01

... game authorities, except that: (a) No person shall purchase, sell, barter, or offer to purchase, sell, or barter for millinery or ornamental use the feathers of migratory game birds taken under authority... mounted specimens of migratory game birds taken under authority of this part. [38 FR 22021, Aug. 15, 1973...

50 CFR 20.91 - Commercial use of feathers.

Code of Federal Regulations, 2011 CFR

2011-10-01

... game authorities, except that: (a) No person shall purchase, sell, barter, or offer to purchase, sell, or barter for millinery or ornamental use the feathers of migratory game birds taken under authority... mounted specimens of migratory game birds taken under authority of this part. [38 FR 22021, Aug. 15, 1973...

50 CFR 20.91 - Commercial use of feathers.

Code of Federal Regulations, 2013 CFR

2013-10-01

... game authorities, except that: (a) No person shall purchase, sell, barter, or offer to purchase, sell, or barter for millinery or ornamental use the feathers of migratory game birds taken under authority... mounted specimens of migratory game birds taken under authority of this part. [38 FR 22021, Aug. 15, 1973...

50 CFR 20.91 - Commercial use of feathers.

Code of Federal Regulations, 2010 CFR

2010-10-01

... game authorities, except that: (a) No person shall purchase, sell, barter, or offer to purchase, sell, or barter for millinery or ornamental use the feathers of migratory game birds taken under authority... mounted specimens of migratory game birds taken under authority of this part. [38 FR 22021, Aug. 15, 1973...

50 CFR 20.91 - Commercial use of feathers.

Code of Federal Regulations, 2014 CFR

2014-10-01

... game authorities, except that: (a) No person shall purchase, sell, barter, or offer to purchase, sell, or barter for millinery or ornamental use the feathers of migratory game birds taken under authority... mounted specimens of migratory game birds taken under authority of this part. [38 FR 22021, Aug. 15, 1973...

A New Breed of Environmental Film

ERIC Educational Resources Information Center

Malamud, Randy

2008-01-01

In this article, the author reports how today's environmental film festivals feature a new breed of documentary that offer nuanced narratives about intricate technologies. The author relates that the environmental films he grew up with sedately depicted the quiet sublimity of the wilderness. Today's films, the author observes, aim far beyond a…

Evaluating the impact of a disease management program for chronic complex conditions at two large northeast health plans using a control group methodology.

PubMed

Schwerner, Henry; Mellody, Timothy; Goldstein, Allan B; Wansink, Daryl; Sullivan, Virginia; Yelenik, Stephan N; Charlton, Warwick; Lloyd, Kelley; Courtemanche, Ted

2006-02-01

The objective of this study was to observe trends in payer expenditures for plan members with one of 14 chronic, complex conditions comparing one group with a disease management program specific to their condition (the intervention group) and the other with no specific disease management program (the control group) for these conditions. The authors used payer claims and membership data to identify members eligible for the program in a 12-month baseline year (October 2001 to September 2002) and a subsequent 12-month program year (October 2002 to September 2003). Two payers were analyzed: one health plan with members primarily in New Jersey (AmeriHealth New Jersey [AHNJ]), where the disease management program was offered, and one affiliated large plan with members primarily in the metro Philadelphia area, where the program was not offered. The claims payment policy for both plans is identical. Intervention and control groups were analyzed for equivalence. The analysis was conducted in both groups over identical time periods. The intervention group showed statistically significant (p < 0.01) differences in total paid claims trend and expenditures when compared to the control group. Intervention group members showed a reduction in expenditures of -8%, while control group members showed an increase of +10% over identical time periods. Subsequent analyses controlling for outliers and product lines served to confirm the overall results. The disease management program is likely responsible for the observed difference between the intervention and control group results. A well-designed, targeted disease management program offered by a motivated, supportive health plan can play an important role in cost improvement strategies for members with complex, chronic conditions.

What mental health teams want in their leaders.

PubMed

Corrigan, P W; Garman, A N; Lam, C; Leary, M

1998-11-01

The authors present the findings of the first phase of a 3-year study developing a skills training curriculum for mental health team leaders. A factor model empirically generated from clinical team members was compared to Bass' (1990) Multifactor Model of Leadership. Members of mental health teams generated individual responses to questions about effective leaders. Results from this survey were subsequently administered to a sample of mental health team members. Analysis of these data yielded six factors: Autocratic Leadership, Clear Roles and Goals, Reluctant Leadership, Vision, Diversity Issues, and Supervision. Additional analyses suggest Bass' Multifactor Model offers a useful paradigm for developing a curriculum specific to the needs of mental health team leaders.

The Timing and Function of Offers in U.S. and Japanese Negotiations

ERIC Educational Resources Information Center

Adair, Wendi L.; Weingart, Laurie; Brett, Jeanne

2007-01-01

The authors examined the function of offers in U.S. and Japanese integrative negotiations. They proposed that early 1st offers begin information sharing and generate joint gains in Japan but have an anchoring effect that hinders joint gains in the United States. The data from the negotiation transcripts of 20 U.S. and 20 Japanese dyads supported 2…

78 FR 45494 - Notice of Second Sugar Purchase and Exchange for Re-export Program Credits

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-29

... raw cane sugar to be offered in exchange for Refined Sugar Re- export Program credits as a follow-up..., 2013. CCC will invite domestic sugarcane processors to offer raw cane sugar to CCC, as authorized by...

A Support Group Offers Help for Parents of Hyperactive Children.

ERIC Educational Resources Information Center

Pond, Elizabeth F.; Gilbert, Charlotte M.

1987-01-01

Describes the development of a parents' support group in Augusta, Georgia which offers parents of hyperactive and Attention Deficit Disorder (ADD) children an opportunity to share experiences and explore problem-solving strategies for coping with and managing their children. (Author/BB)

More of a Screen Than a Barrier?

ERIC Educational Resources Information Center

Anderson, Eric; Bogdanor, Vernon

1977-01-01

"The central issue ought to be the development of curricula suited to the differing needs of people of differing abilities". Authors offer a proposal which would allow local authorities to introduce selection at 14. (Editor)

Managed care contracting: a systematic approach.

PubMed

Flores, K

1987-12-01

Managed care is sweeping the health care industry and has produced some special challenges for providers. Success in contracting depends on preparation. In this article, the author defines managed care and outlines who should be involved in the contracting for these services. Special attention is given to how to develop the appropriate internal support. The author contends that a provider should not embrace all contracting offers and suggests criteria for selection of the best offers. Finally, the prevailing pricing schemes are reviewed and caveats given on their interpretation and use.

Theatre and pedagogy: using drama in mental health nurse education.

PubMed

Wasylko, Yolanda; Stickley, Theodore

2003-08-01

Drama is a feature of all civilisations. It has long been used as an educative tool. In this paper, the authors advocate for the use of drama in mental health nurse education. An historical overview of the relationship between drama and education is offered. Through their own experiences the authors give examples of the use of drama in the classroom. Drama challenges the power position of the participants, teacher and student alike. A humanistic framework is offered that promotes empathic understanding between all those concerned, especially the client.

Structured Course Objects in a Digital Library

NASA Technical Reports Server (NTRS)

Maly, K.; Zubair, M.; Liu, X.; Nelson, M.; Zeil, S.

1999-01-01

We are developing an Undergraduate Digital Library Framework (UDLF) that will support creation/archiving of courses and reuse of existing course material to evolve courses. UDLF supports the publication of course materials for later instantiation for a specific offering and allows the addition of time-dependent and student-specific information and structures. Instructors and, depending on permissions, students can access the general course materials or the materials for a specific offering. We are building a reference implementation based on NCSTRL+, a digital library derived from NCSTRL. Digital objects in NCSTRL+ are called buckets, self-contained entities that carry their own methods for access and display. Current bucket implementations have a two level structure of packages and elements. This is not a rich enough structure for course objects in UDLF. Typically, courses can only be modeled as a multilevel hierarchy and among different courses, both the syntax and semantics of terms may vary. Therefore, we need a mechanism to define, within a particular library, course models, their constituent objects, and the associated semantics in a flexible, extensible way. In this paper, we describe our approach to define and implement these multilayered course objects. We use XML technology to emulate complex data structures within the NCSTRL+ buckets. We have developed authoring and browsing tools to manipulate these course objects. In our current implementation a user downloading an XML based course bucket also downloads the XML-aware tools: an applet that enables the user to edit or browse the bucket. We claim that XML provides an effective means to represent multi-level structure of a course bucket.

A survey of Canadian websites providing information about female urinary incontinence.

PubMed

Farrell, Karen D; Robinson, Lynne M; Baydock, Sandra A; Farrell, Scott A; Irving, Linda E; O'Connell, Colleen M

2006-08-01

Urinary incontinence (UI) is a prevalent health issue that has significant detrimental effects on quality of life. The Internet offers a unique vehicle for incontinent women to access information that could facilitate conservative self-help therapy. An evaluation of Canadian websites offering female UI information was conducted to determine their quality and readability. We evaluated websites using published general quality criteria for health sites and a quality assessment tool compiled by the authors for specific UI information derived from published, peer-reviewed clinical practice guidelines. Three health care professionals reviewed sites for quality, Canadian content, and interactivity. The readability of health information was also evaluated. Fifty-six Canadian sites (18 professional, 22 organizational, 16 commercial) were evaluated. Significant agreement was found among the raters' evaluations on all measures. For all sites, the mean scores were general quality, 9/14; specific UI quality, 30/122; reading ease, 37/100; grade level, 10.9. The median score for Canadian content was high, but for interactivity it was low. The only significant difference between site types was for general quality (F [2,165]=3.38, P=0.036). Post hoc Tukey's tests showed a significant difference between organizational and commercial sites, with organizational sites having higher general quality. Canadian websites providing female UI information have moderately high general quality, low specific UI information quality, minimal interactivity, and more than minimal Canadian content. The reading level of most sites is too high for average consumers. A webliography of the best sites has been developed to guide patients.

Mole gun injury.

PubMed

Pistré, V; Rezzouk, J

2013-09-01

A mole gun is a weapon, which is used to trap and kill moles. This report provides an overview of the state of knowledge of mole gun injuries, comparable to blast injuries caused by fireworks, explosive or gunshot. Over a 2-year period, the authors reported their experience with ten hand injuries caused by mole gun. Radial side of the hand was often concerned, particularly the thumb. The authors explain their choices in the management of such lesions. Surgery was performed primarily and a large debridement currently seemed to offer the best outcome for the patient. Blast, crush, burns and lacerations may explain the higher rate of amputation to the digits. A long period of physiotherapy, specifically of the hand, was needed before the patient could return to work. This ballistic hand trauma encountered by surgeons requires knowledge and understanding of these injuries. It should be in accordance with firearms law because of severe injuries encountered and possible lethal wounds. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

How Research on Charitable Giving Can Inform Strategies to Promote Human Milk Donations to Milk Banks.

PubMed

Stevens, Jack; Keim, Sarah A

2015-08-01

Many hospitalized preterm infants do not exclusively receive mother's own milk, so milk from another mother may be sought. Previous research indicated that just 1% of US women who express breast milk actually donate it for another family. Therefore, strategies to boost donation rates should be identified. We draw upon the experimental literature on charitable giving of monetary donations to offer 6 strategies to promote breast milk donations to milk banks in North America. These strategies include (1) highlighting a potential identifiable recipient of donated breast milk as opposed to highlighting groups of potential recipients; (2) emphasizing similarities between the potential donor and potential beneficiaries; (3) emphasizing similarities between the potential donor and previous donors; (4) using negative arousal to promote donations; (5) emphasizing the self-interest of those asking for breast milk donations; and (6) highlighting the specific effect of breast milk donations. Potential limitations of these strategies are discussed. © The Author(s) 2015.

Subjective experiences of an art museum engagement activity for persons with early-stage Alzheimer's disease and their family caregivers.

PubMed

Flatt, Jason D; Liptak, Amy; Oakley, Mary Ann; Gogan, Jessica; Varner, Tresa; Lingler, Jennifer H

2015-06-01

To describe the subjective experiences of older adults with early-stage Alzheimer's disease or related cognitive disorders (ADRDs) and their family caregivers who participated in an art museum engagement activity. Four focus groups were conducted with 10 persons with ADRD and 10 family caregivers following the completion of a 1-time, 3-hour engagement activity. Participants also completed a brief satisfaction survey, and associations were examined using nonparametric statistics. Three key themes were identified: cognitive stimulation, social connections, and self-esteem. In addition, we identified programmatic issues such as activity-specific concerns and program logistics that could help improve future art program offerings. Past experience with art and perceived social cohesion were correlated with participants' overall satisfaction with the program. Efforts aimed at improving the quality of life of those with Alzheimer's disease and their family caregivers should consider the potential role of art museums. © The Author(s) 2014.

Cotard's delusion or syndrome?: a conceptual history.

PubMed

Berrios, G E; Luque, R

1995-01-01

This report offers an account of the historical construction of Cotard's syndrome showing that by délire des négations the French author meant a subtype of depressive illness. Subsequent debate led first to the belief that it was just a collection of symptoms associated with agitated depression (anxious melancholia) or general paralysis, and later to the view that it might after all constitute a separate entity. At the present moment, and impervious to the fact that the French term délire means far more than "delusion," some authors use Cotard's syndrome to refer to the belief of being dead and suggest that such a delusion might have a specific brain location. From the clinical and evolutionary perspective, it is unclear why a delusion should merit, simply because of its "nihilistic" content, a special brain location or presage chronicity. It is suggested here that before neurobiologic speculation starts, efforts should be made to map out the clinical features and correlations of the délire des négations.

Rethinking procrastination: positive effects of "active" procrastination behavior on attitudes and performance.

PubMed

Chu, Angela Hsin Chun; Choi, Jin Nam

2005-06-01

Researchers and practitioners have long regarded procrastination as a self-handicapping and dysfunctional behavior. In the present study, the authors proposed that not all procrastination behaviors either are harmful or lead to negative consequences. Specifically, the authors differentiated two types of procrastinators: passive procrastinators versus active procrastinators. Passive procrastinators are procrastinators in the traditional sense. They are paralyzed by their indecision to act and fail to complete tasks on time. In contrast, active procrastinators are a "positive" type of procrastinator. They prefer to work under pressure, and they make deliberate decisions to procrastinate. The present results showed that although active procrastinators procrastinate to the same degree as passive procrastinators, they are more similar to nonprocrastinators than to passive procrastinators in terms of purposive use of time, control of time, self-efficacy belief, coping styles, and outcomes including academic performance. The present findings offer a more sophisticated understanding of procrastination behavior and indicate a need to reevaluate its implications for outcomes of individuals.

Intra- Versus Intersex Aggression: Testing Theories of Sex Differences Using Aggression Networks.

PubMed

Wölfer, Ralf; Hewstone, Miles

2015-08-01

Two theories offer competing explanations of sex differences in aggressive behavior: sexual-selection theory and social-role theory. While each theory has specific strengths and limitations depending on the victim's sex, research hardly differentiates between intrasex and intersex aggression. In the present study, 11,307 students (mean age = 14.96 years; 50% girls, 50% boys) from 597 school classes provided social-network data (aggression and friendship networks) as well as physical (body mass index) and psychosocial (gender and masculinity norms) information. Aggression networks were used to disentangle intra- and intersex aggression, whereas their class-aggregated sex differences were analyzed using contextual predictors derived from sexual-selection and social-role theories. As expected, results revealed that sexual-selection theory predicted male-biased sex differences in intrasex aggression, whereas social-role theory predicted male-biased sex differences in intersex aggression. Findings suggest the value of explaining sex differences separately for intra- and intersex aggression with a dual-theory framework covering both evolutionary and normative components. © The Author(s) 2015.

Social network characteristics and resource access among formerly displaced households in Lira, Uganda.

PubMed

Obaa, Bernard B; Mazur, Robert E

2017-07-01

In rural African communities, the support of extended family, friends, and neighbours is essential in borrowing or leveraging land, labour, food, and money, especially at times of social and financial turmoil. Little is known, though, about the nature of the networks and the conditions under which they may generate greater support in post-conflict communities. This study, conducted in the Lira district of northern Uganda, examined the composition, proximity, and size of the networks that households utilise to gain access to resources during and after resettlement. Network structures with more kin and co-resident ties were found to offer greater resource access to households in post-conflict settings. Furthermore, there was a lack of meaningful linkages outside of a person's own village, especially with regard to households whose head has no or a low level of education. These findings enhance understanding of the specific role of relationships in social support for resource access among households in post-conflict communities. © 2017 The Author(s). Disasters © Overseas Development Institute, 2017.

Technological advances in bovine mastitis diagnosis: an overview.

PubMed

Duarte, Carla M; Freitas, Paulo P; Bexiga, Ricardo

2015-11-01

Bovine mastitis is an economic burden for dairy farmers and preventive control measures are crucial for the sustainability of any dairy business. The identification of etiological agents is necessary in controlling the disease, reducing risk of chronic infections and targeting antimicrobial therapy. The suitability of a detection method for routine diagnosis depends on several factors, including specificity, sensitivity, cost, time in producing results, and suitability for large-scale sampling of milk. This article focuses on current methodologies for identification of mastitis pathogens and for detection of inflammation, as well as the advantages and disadvantages of different methods. Emerging technologies, such as transcriptome and proteome analyses and nano- and microfabrication of portable devices, offer promising, sensitive methods for advanced detection of mastitis pathogens and biomarkers of inflammation. The demand for alternative, fast, and reliable diagnostic procedures is rising as farms become bigger. Several examples of technological and scientific advances are summarized which have given rise to more sensitive, reliable and faster diagnostic results. © 2015 The Author(s).

Nonprofit to for-profit conversions by hospitals, health insurers, and health plans.

PubMed Central

Needleman, J

1999-01-01

Conversion of hospitals, health insurers, and health plans from nonprofit to for-profit ownership has become a focus of national debate. The author examines why nonprofit ownership has been dominant in the US health system and assesses the strength of the argument that nonprofits provide community benefits that would be threatened by for-profit conversion. The author concludes that many of the specific community benefits offered by nonprofits, such as care for the poor, could be maintained or replaced by adequate funding of public programs and that quality and fairness in treatment can be better assured through clear standards of care and adequate monitoring systems. As health care becomes increasingly commercialized, the most difficult parts of nonprofits' historic mission to preserve are the community orientation, leadership role, and innovation that nonprofit hospitals and health plans have provided out of their commitment to a community beyond those to whom they sell services. Images p109-a p110-a p115-a p116-a PMID:10199712

Rethinking infant knowledge: toward an adaptive process account of successes and failures in object permanence tasks.

PubMed

Munakata, Y; McClelland, J L; Johnson, M H; Siegler, R S

1997-10-01

Infants seem sensitive to hidden objects in habituation tasks at 3.5 months but fail to retrieve hidden objects until 8 months. The authors first consider principle-based accounts of these successes and failures, in which early successes imply knowledge of principles and failures are attributed to ancillary deficits. One account is that infants younger than 8 months have the object permanence principle but lack means-ends abilities. To test this, 7-month-olds were trained on means-ends behaviors and were tested on retrieval of visible and occluded toys. Means-ends demands were the same, yet infants made more toy-guided retrievals in the visible case. The authors offer an adaptive process account in which knowledge is graded and embedded in specific behavioral processes. Simulation models that learn gradually to represent occluded objects show how this approach can account for success and failure in object permanence tasks without assuming principles and ancillary deficits.

Internet firewalls: questions and answers

NASA Astrophysics Data System (ADS)

Ker, Keith

1996-03-01

As organizations consider connecting to the Internet, the issue of internetwork security becomes more important. There are many tools and components that can be used to secure a network, one of which is a firewall. Modern firewalls offer highly flexible private network security by controlling and monitoring all communications passing into or out of the private network. Specifically designed for security, firewalls become the private network's single point of attack from Internet intruders. Application gateways (or proxies) that have been written to be secure against even the most persistent attacks ensure that only authorized users and services access the private network. One-time passwords prevent intruders from `sniffing' and replaying the usernames and passwords of authorized users to gain access to the private network. Comprehensive logging permits constant and uniform system monitoring. `Address spoofing' attacks are prevented. The private network may use registered or unregistered IP addresses behind the firewall. Firewall-to-firewall encryption establishes a `virtual private network' across the Internet, preventing intruders from eavesdropping on private communications, eliminating the need for costly dedicated lines.

Alternative approaches to pollution control and waste management: Regulatory and economic instruments. Planteamientos alternos para el control de la contaminacion y el manejo de desechos: instrumentos regulatorios y economicos

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bernstein, J.D.

1993-01-01

The paper examines ways in which developed and developing countries control pollution and manage urban wastes. It addresses pollution issues of concern to local, provincial, and national governments, as well as nongovernmental organizations. Two approaches to pollution management are discussed: direct regulation and economic incentives. Direct regulation sets standards and enforces them through permits, licenses, and controls on land or water use. Economic incentives encourage polluters to adopt control measures and are more flexible and cost effective. Such incentives include charging fees to enterprises for pollution discharges or providing government subsidies for pollution control technology. The author tells how economicmore » incentives can supplement direct regulation and why such incentives, when properly used, offer advantages over direct regulation. The author discusses how governments have used economic incentives to deal with specific environmental issues and what factors policymakers must address when they plan pollution controls.« less

Natural versus anthropogenic climate change: Swedish farmers' joint construction of climate perceptions.

PubMed

Asplund, Therese

2016-07-01

While previous research into understandings of climate change has usually examined general public perceptions, this study offers an audience-specific departure point. This article analyses how Swedish farmers perceive climate change and how they jointly shape their understandings. The agricultural sector is of special interest because it both contributes to and is directly affected by climate change. Through focus group discussions with Swedish farmers, this study finds that (1) farmers relate to and understand climate change through their own experiences, (2) climate change is understood either as a natural process subject to little or no human influence or as anthropogenic and (3) various communication tools contribute to the formation of natural and anthropogenic climate change frames. The article ends by discussing frame resonance and frame clash in public understanding of climate change and by comparing potential similarities and differences in how various segments of the public make sense of climate change. © The Author(s) 2014.

Shelter strategies, humanitarian praxis and critical urban theory in post-crisis reconstruction.

PubMed

Fan, Lilianne

2012-07-01

The paper seeks to link contemporary thinking on urban shelter in the humanitarian sector to debates in the field of 'critical urban theory'. It argues that current humanitarian thinking on urban shelter shares many common concerns with critical urban theory, but that these concerns are rarely translated effectively into humanitarian practice. It attributes this disconnect not only to weaknesses in implementation capacity, but also to the need to reorient humanitarian action to address more definitively questions of power and justice. Humanitarian actors need to step back from product-delivery approaches and find ways of integrating into their analytical, planning, implementation and monitoring tools questions about access, exclusion and the historically specific ways in which these aspects converge in particular urban spaces. By doing so, the humanitarian community would benefit from a more explicit, systematic and sustained engagement with the catalytic theoretical resources that critical urban theory has to offer. © 2012 The Author(s). Journal compilation © Overseas Development Institute, 2012.

Balancing dual roles in end-of-life research.

PubMed

Martin, Wanda; Grey, Meredith; Webber, Terry; Robinson, Linnea; Hartt, Nancy; Cairns, Moira; Stajduhar, Kelli

2007-01-01

Ethical and practical issues are sure to arise from the majority of research studies done with palliative populations. Whether it is feeling opportunistic, being emotionally available, or struggling with witnessing a gap in service and needs of the participants receiving care, nurses involved in research find a way to balance both roles to meet the needs of the participants as well as the study (McIlfatrick, Sullivan, & McKenna, 2006). This paper highlights some of the practical and ethical issues that arise when frontline nurses also take on the role of research assistant for studies with palliative populations. Specifically, the authors highlight their personal experiences based on their research assistant work on a study examining family caregiver coping in end-of-life cancer care. The authors discuss the "balancing act" of taking on these dual roles and offer recommendations on how to be with and approach people when doing research at the end of life using a framework based on Swanson's Theory of Caring (1991).

Disaster risk reduction and 'built-in' resilience: towards overarching principles for construction practice.

PubMed

Bosher, Lee; Dainty, Andrew

2011-01-01

The emerging emphasis on disaster risk reduction has broadened the range of experts whose knowledge must be garnered to resolve complex socio-technical challenges. This paper examines the role and position of the construction sector for addressing these concerns. Specifically, it examines the recursive nature of practices within the built environment, which can be seen as deeply ingraining fragmented approaches to the development process. These, in turn, render the industry a difficult arena within which to enact structural and cultural change. Based on a wide body of literature on resiliency a set of overarching principles are proffered to help inform efforts to overcome some of the barriers to creating a more resilient built environment. It is argued that these principles offer a point of departure for embedding resilience considerations at both project and institutional levels, although real change would demand challenging some of the conventions that currently underpin construction development. © 2011 The Author(s). Disasters © Overseas Development Institute, 2011.

Identity, place, and bystander intervention: social categories and helping after natural disasters.

PubMed

Levine, Mark; Thompson, Kirstien

2004-06-01

The authors developed a Self-Categorization Theory (SCT) approach to bystander behavior. Participants were 100 undergraduates at an English university. The authors made either a European or a British identity salient. Participants then rated their likelihood of offering both financial and political help after natural disasters in Europe and South America. When European (but not British) identity was salient, participants were less likely to offer help for disasters in South America than Europe. They were also more likely to offer financial help after disasters in Europe when European non-British identity was salient. There were no differences in levels of emotional response to disasters by identity salience. Results indicate that social category relations rather than geographical proximity or emotional reaction are most important in increasing helping behavior after natural disasters.

Human pluripotent stem cells as tools for neurodegenerative and neurodevelopmental disease modeling and drug discovery.

PubMed

Corti, Stefania; Faravelli, Irene; Cardano, Marina; Conti, Luciano

2015-06-01

Although intensive efforts have been made, effective treatments for neurodegenerative and neurodevelopmental diseases have not been yet discovered. Possible reasons for this include the lack of appropriate disease models of human neurons and a limited understanding of the etiological and neurobiological mechanisms. Recent advances in pluripotent stem cell (PSC) research have now opened the path to the generation of induced pluripotent stem cells (iPSCs) starting from somatic cells, thus offering an unlimited source of patient-specific disease-relevant neuronal cells. In this review, the authors focus on the use of human PSC-derived cells in modeling neurological disorders and discovering of new drugs and provide their expert perspectives on the field. The advent of human iPSC-based disease models has fuelled renewed enthusiasm and enormous expectations for insights of disease mechanisms and identification of more disease-relevant and novel molecular targets. Human PSCs offer a unique tool that is being profitably exploited for high-throughput screening (HTS) platforms. This process can lead to the identification and optimization of molecules/drugs and thus move forward new pharmacological therapies for a wide range of neurodegenerative and neurodevelopmental conditions. It is predicted that improvements in the production of mature neuronal subtypes, from patient-specific human-induced pluripotent stem cells and their adaptation to culture, to HTS platforms will allow the increased exploitation of human pluripotent stem cells in drug discovery programs.

Biochemical characterization of two GH70 family 4,6-α-glucanotransferases with distinct product specificity from Lactobacillus aviarius subsp. aviarius DSM 20655.

PubMed

Meng, Xiangfeng; Gangoiti, Joana; de Kok, Niels; van Leeuwen, Sander S; Pijning, Tjaard; Dijkhuizen, Lubbert

2018-07-01

Nine GtfB-like 4,6-α-glucanotransferases (4,6-α-GTs) (represented by GtfX of L. aviarius subsp. aviarius DSM 20655) were identified to show distinct characteristics in conserved motifs I-IV. In particular, the "fingerprint" Tyr in motif III of these nine GtfB-type 4,6-α-GTs was found to be replaced by a Trp. In L. aviarius subsp. aviarius DSM20655, a second GtfB-like protein (GtfY), containing the canonical GtfB Tyr residue in motif III, was located directly upstream of GtfX. Biochemical characterization revealed that both GtfX and GtfY showed GtfB-like 4,6-α-GT activity, cleaving (α1→4) linkages and catalyzing the synthesis of (α1→6) linkages. Nonetheless, they differ in product specificity; GtfY only synthesizes consecutive (α1→6) linkages, yielding linear α-glucan products, but GtfX catalyzes the synthesis of (α1→6) linkages predominantly at branch points (22%) rather than in linear segments (10%). The highly branched α-glucan produced by GtfX from amylose V is resistant to digestion by α-amylase, offering great potential as dietary fibers. Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

A historical examination of the Budin-Pinard phantom: what can contemporary obstetrics education learn from simulators of the past?

PubMed

Owen, Harry; Pelosi, Marco A

2013-05-01

In the 19th and early 20th centuries, obstetric simulators were widely used in medical schools to teach patient assessment skills and to allow students to learn and practice management of a wide range of conditions. Several types of simulators were manufactured, but one, known as the Budin-Pinard phantom, was specifically identified and recommended by J. Whitridge Williams of Johns Hopkins University in a paper he presented to the June 1898 meeting of the Association of American Medical Colleges. Obstetrics simulation became less popular as more women were encouraged to deliver in hospitals, providing trainees the opportunity to learn from actual patients. Today, though, simulation is undergoing a renaissance in obstetrics as a tool to improve learning and patient safety. In light of this shift, the authors examine the origins of simulation in obstetrics training, and specifically why Williams recommended the Budin-Pinard simulator in particular. They investigate the context of simulation in U.S. and Canadian obstetrics training generally up to the early 20th century and provide details about the Budin-Pinard simulator. Finally, the authors offer a discussion of how the Budin-Pinard simulator shaped obstetrics training in the 19th and early 20th centuries and how it can contribute to modern medical education.

Fundamental constructs in food parenting practices: a content map to guide future research.

PubMed

Vaughn, Amber E; Ward, Dianne S; Fisher, Jennifer O; Faith, Myles S; Hughes, Sheryl O; Kremers, Stef P J; Musher-Eizenman, Dara R; O'Connor, Teresia M; Patrick, Heather; Power, Thomas G

2016-02-01

Although research shows that "food parenting practices" can impact children's diet and eating habits, current understanding of the impact of specific practices has been limited by inconsistencies in terminology and definitions. This article represents a critical appraisal of food parenting practices, including clear terminology and definitions, by a working group of content experts. The result of this effort was the development of a content map for future research that presents 3 overarching, higher-order food parenting constructs--coercive control, structure, and autonomy support--as well as specific practice subconstructs. Coercive control includes restriction, pressure to eat, threats and bribes, and using food to control negative emotions. Structure includes rules and limits, limited/guided choices, monitoring, meal- and snacktime routines, modeling, food availability and accessibility, food preparation, and unstructured practices. Autonomy support includes nutrition education, child involvement, encouragement, praise, reasoning, and negotiation. Literature on each construct is reviewed, and directions for future research are offered. Clear terminology and definitions should facilitate cross-study comparisons and minimize conflicting findings resulting from previous discrepancies in construct operationalization. © The Author(s) 2016. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Human research ethics committees in technical universities.

PubMed

Koepsell, David; Brinkman, Willem-Paul; Pont, Sylvia

2014-07-01

Human research ethics has developed in both theory and practice mostly from experiences in medical research. Human participants, however, are used in a much broader range of research than ethics committees oversee, including both basic and applied research at technical universities. Although mandated in the United States, the United Kingdom, Canada, and Australia, non-medical research involving humans need not receive ethics review in much of Europe, Asia, Latin America, and Africa. Our survey of the top 50 technical universities in the world shows that, where not specifically mandated by law, most technical universities do not employ ethics committees to review human studies. As the domains of basic and applied sciences expand, ethics committees are increasingly needed to guide and oversee all such research regardless of legal requirements. We offer as examples, from our experience as an ethics committee in a major European technical university, ways in which such a committee provides needed services and can help ensure more ethical studies involving humans outside the standard medical context. We provide some arguments for creating such committees, and in our supplemental article, we provide specific examples of cases and concerns that may confront technical, engineering, and design research, as well as outline the general framework we have used in creating our committee. © The Author(s) 2014.

Systemic evaluation of cellular reprogramming processes exploiting a novel R-tool: eegc.

PubMed

Zhou, Xiaoyuan; Meng, Guofeng; Nardini, Christine; Mei, Hongkang

2017-08-15

Cells derived by cellular engineering, i.e. differentiation of induced pluripotent stem cells and direct lineage reprogramming, carry a tremendous potential for medical applications and in particular for regenerative therapies. These approaches consist in the definition of lineage-specific experimental protocols that, by manipulation of a limited number of biological cues-niche mimicking factors, (in)activation of transcription factors, to name a few-enforce the final expression of cell-specific (marker) molecules. To date, given the intricate complexity of biological pathways, these approaches still present imperfect reprogramming fidelity, with uncertain consequences on the functional properties of the resulting cells. We propose a novel tool eegc to evaluate cellular engineering processes, in a systemic rather than marker-based fashion, by integrating transcriptome profiling and functional analysis. Our method clusters genes into categories representing different states of (trans)differentiation and further performs functional and gene regulatory network analyses for each of the categories of the engineered cells, thus offering practical indications on the potential lack of the reprogramming protocol. eegc R package is released under the GNU General Public License within the Bioconductor project, freely available at https://bioconductor.org/packages/eegc/. christine.nardini.rsrc@gmail.com or hongkang.k.mei@gsk.com. Supplementary data are available at Bioinformatics online. © The Author(s) 2017. Published by Oxford University Press.

Programmable DNA-binding proteins from Burkholderia provide a fresh perspective on the TALE-like repeat domain.

PubMed

de Lange, Orlando; Wolf, Christina; Dietze, Jörn; Elsaesser, Janett; Morbitzer, Robert; Lahaye, Thomas

2014-06-01

The tandem repeats of transcription activator like effectors (TALEs) mediate sequence-specific DNA binding using a simple code. Naturally, TALEs are injected by Xanthomonas bacteria into plant cells to manipulate the host transcriptome. In the laboratory TALE DNA binding domains are reprogrammed and used to target a fused functional domain to a genomic locus of choice. Research into the natural diversity of TALE-like proteins may provide resources for the further improvement of current TALE technology. Here we describe TALE-like proteins from the endosymbiotic bacterium Burkholderia rhizoxinica, termed Bat proteins. Bat repeat domains mediate sequence-specific DNA binding with the same code as TALEs, despite less than 40% sequence identity. We show that Bat proteins can be adapted for use as transcription factors and nucleases and that sequence preferences can be reprogrammed. Unlike TALEs, the core repeats of each Bat protein are highly polymorphic. This feature allowed us to explore alternative strategies for the design of custom Bat repeat arrays, providing novel insights into the functional relevance of non-RVD residues. The Bat proteins offer fertile grounds for research into the creation of improved programmable DNA-binding proteins and comparative insights into TALE-like evolution. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

Interdisciplinary Dimensions in Entrepreneurship

ERIC Educational Resources Information Center

Levenburg, Nancy M.; Lane, Paul M.; Schwarz, Thomas V.

2006-01-01

Entrepreneurship programs and courses are offered by many business schools to support students who aspire to start, own, and operate businesses. Although these offerings are directed primarily toward business majors, based on data the authors collected from over 700 students, many nonbusiness majors also possess entrepreneurial characteristics and…

12 CFR 48.1 - Authority, purpose, and scope.

Code of Federal Regulations, 2013 CFR

2013-01-01

....1 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RETAIL FOREIGN EXCHANGE... or enter into retail foreign exchange transactions. A national bank offering or entering into retail... associations. A Federal savings association may offer or enter into retail foreign exchange transactions. A...

Anchors weigh more than power: why absolute powerlessness liberates negotiators to achieve better outcomes.

PubMed

Schaerer, Michael; Swaab, Roderick I; Galinsky, Adam D

2015-02-01

The current research shows that having no power can be better than having a little power. Negotiators prefer having some power (weak negotiation alternatives) to having no power (no alternatives). We challenge this belief that having any alternative is beneficial by demonstrating that weak alternatives create low anchors that reduce the value of first offers. In contrast, having no alternatives is liberating because there is no anchor to weigh down first offers. In our experiments, negotiators with no alternatives felt less powerful but made higher first offers and secured superior outcomes compared with negotiators who had weak alternatives. We established the role of anchoring through mediation by first offers and through moderation by showing that weak alternatives no longer led to worse outcomes when negotiators focused on a countervailing anchor or when negotiators faced an opponent with a strong alternative. These results demonstrate that anchors can have larger effects than feelings of power. Absolute powerlessness can be psychologically liberating. © The Author(s) 2014.

Prevention Activities in Professional Psychology: A Reaction to the Prevention Guidelines

ERIC Educational Resources Information Center

Rivera-Mosquera, Evelyn; Dowd, E. Thomas; Mitchell-Blanks, Marsha

2007-01-01

In this reaction article, the authors provide a historical context for prevention activities and their place in psychological practice. They then discuss the prevention guidelines in the Major Contribution authored by S. M. Hage et al. (2007 [this issue]) and provide their critique. Finally, the authors offer ideas for the future specific…

Authors, Authors, Authors

ERIC Educational Resources Information Center

Harvey, Carl A., II; Kaplan, Allison G.

2007-01-01

This article features some of the programs offered in the Reno conference. Two of the preconferences at Reno will focus on children's literature. Judy Freeman will talk about some of the current and future trends for books for younger readers. She will share a plethora of some of the best picture books and chapter books. Ruth Cox Clark will take…

28 CFR 8.3 - Designation of the investigative bureau having administrative forfeiture authority; claims for...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Designation of the investigative bureau having administrative forfeiture authority; claims for awards, offers in compromise and matters relating to bonds. 8.3 Section 8.3 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR...

28 CFR 8.3 - Designation of the investigative bureau having administrative forfeiture authority; claims for...

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Designation of the investigative bureau having administrative forfeiture authority; claims for awards, offers in compromise and matters relating to bonds. 8.3 Section 8.3 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR...

28 CFR 8.3 - Designation of the investigative bureau having administrative forfeiture authority; claims for...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Designation of the investigative bureau having administrative forfeiture authority; claims for awards, offers in compromise and matters relating to bonds. 8.3 Section 8.3 Judicial Administration DEPARTMENT OF JUSTICE FBI FORFEITURE AUTHORITY FOR...

Logistics of Behavior Screenings: How and Why Do We Conduct Behavior Screenings at Our School?

ERIC Educational Resources Information Center

Oakes, Wendy Peia; Lane, Kathleen Lynne; Cox, Meredith Lucille; Messenger, Mallory

2014-01-01

In this article, the authors provide an overview of behavior screening tools available, including free and commercially available options. Next, the authors offer step-by-step procedures for (a) selecting, (b) scheduling, (c) preparing, (d) administering, and (e) scoring and interpreting behaviors screening tools. The authors conclude with…

"Honey, Won't You Please Stay Home?"

ERIC Educational Resources Information Center

Roach, Rose Marie

1976-01-01

The author examines the stress produced in a "reentry woman's" interpersonal relationships with her husband and family in terms of balance theory. She also offers suggestions as to how colleges might develop programs to help these women. (Author)

Resourcing interventions enhance psychology support capabilities in special operations forces.

PubMed

Myatt, Craig A; Auzenne, J W

2012-01-01

This study provides an examination of approaches to United States Government (USG) resourcing interventions on a national scale that enhance psychology support capabilities in the Special Operations Forces (SOF) community. A review of Congressional legislation and resourcing trends in the form of authorizations and appropriations since 2006 demonstrates how Congress supported enhanced psychology support capabilities throughout the Armed Forces and in SOF supporting innovative command interests that address adverse affects of operations tempo behavioral effects (OTBE). The formulation of meaningful metrics to address SOF specific command interests led to a personnel tempo (PERSTEMPO) analysis in response to findings compiled by the Preservation of the Force and Families (POTFF) Task Force. The review of PERSTEMPO data at subordinate command and unit levels enhances the capability of SOF leaders to develop policy and guidance on training and operational planning that mitigates OTBE and maximizes resourcing authorizations. A major challenge faced by the DoD is in providing behavioral healthcare that meets public and legislative demands while proving suitable and sustainable at all levels of military operations: strategic, operational, and tactical. Current legislative authorizations offer a mechanism of command advocacy for resourced multi-functional program development that enhances psychology support capabilities while reinforcing SOF readiness and performance. 2012.

Introducing medical students to careers in medical education: the student track at an annual medical education conference.

PubMed

Blatt, Benjamin; Plack, Margaret; Suzuki, Mari; Arepalli, Sruthi; Schroth, Scott; Stagnaro-Green, Alex

2013-08-01

Few avenues exist to familiarize medical students with careers as clinician-educators, and the clinician-educator career pathway has not been well defined. In this article, the authors describe how they integrated a career-oriented student track into the 2011 Northeast Group on Educational Affairs (NEGEA) annual retreat to introduce students to careers in medical education. Annual education conferences are principal sources of educational scholarship, networking, collaboration, and information sharing; as such, they represent attractive venues for early exposure to the culture of medical education. The authors' goal in creating the NEGEA conference student track was to excite students about careers in medical education by providing them with an array of opportunities for active involvement in both student-specific and general conference activities.The authors draw from their experience to provide a guide for recruiting student participants to career-building student tracks. They also offer a guide for developing future student tracks, based on their experience and grounded in social cognitive career theory. Although their focus is on medical education, they believe these guides will be useful for educators planning a conference-based student track in any field.

Computational Unification: a Vision for Connecting Researchers

NASA Astrophysics Data System (ADS)

Troy, R. M.; Kingrey, O. J.

2002-12-01

Computational Unification of science, once only a vision, is becoming a reality. This technology is based upon a scientifically defensible, general solution for Earth Science data management and processing. The computational unification of science offers a real opportunity to foster inter and intra-discipline cooperation, and the end of 're-inventing the wheel'. As we move forward using computers as tools, it is past time to move from computationally isolating, "one-off" or discipline-specific solutions into a unified framework where research can be more easily shared, especially with researchers in other disciplines. The author will discuss how distributed meta-data, distributed processing and distributed data objects are structured to constitute a working interdisciplinary system, including how these resources lead to scientific defensibility through known lineage of all data products. Illustration of how scientific processes are encapsulated and executed illuminates how previously written processes and functions are integrated into the system efficiently and with minimal effort. Meta-data basics will illustrate how intricate relationships may easily be represented and used to good advantage. Retrieval techniques will be discussed including trade-offs of using meta-data versus embedded data, how the two may be integrated, and how simplifying assumptions may or may not help. This system is based upon the experience of the Sequoia 2000 and BigSur research projects at the University of California, Berkeley, whose goals were to find an alternative to the Hughes EOS-DIS system and is presently offered by Science Tools corporation, of which the author is a principal.

Disruptive innovation for social change.

PubMed

Christensen, Clayton M; Baumann, Heiner; Ruggles, Rudy; Sadtler, Thomas M

2006-12-01

Countries, organizations, and individuals around the globe spend aggressively to solve social problems, but these efforts often fail to deliver. Misdirected investment is the primary reason for that failure. Most of the money earmarked for social initiatives goes to organizations that are structured to support specific groups of recipients, often with sophisticated solutions. Such organizations rarely reach the broader populations that could be served by simpler alternatives. There is, however, an effective way to get to those underserved populations. The authors call it "catalytic innovation." Based on Clayton Christensen's disruptive-innovation model, catalytic innovations challenge organizational incumbents by offering simpler, good-enough solutions aimed at underserved groups. Unlike disruptive innovations, though, catalytic innovations are focused on creating social change. Catalytic innovators are defined by five distinct qualities. First, they create social change through scaling and replication. Second, they meet a need that is either overserved (that is, the existing solution is more complex than necessary for many people) or not served at all. Third, the products and services they offer are simpler and cheaper than alternatives, but recipients view them as good enough. Fourth, they bring in resources in ways that initially seem unattractive to incumbents. And fifth, they are often ignored, put down, or even encouraged by existing organizations, which don't see the catalytic innovators' solutions as viable. As the authors show through examples in health care, education, and economic development, both nonprofit and for-profit groups are finding ways to create catalytic innovation that drives social change.

The Florence Bird Lecture: "From Strength to Strength: The Interrelated Rights of Women and Children over the Life Cycle"

ERIC Educational Resources Information Center

Pearson, Landon

2012-01-01

This article presents the author's Florence Bird lecture, which was delivered at Carleton University in Ottawa, Canada on International Women's Day, March 8, 2012. In the lecture, the author focuses on the interrelated rights of women and children over the life cycle. The author explores this linkage and offers a caveat. The author shares a…

Disentangling the determinants of interest and willingness-to-pay for breast cancer susceptibility testing in the general population: a cross-sectional Web-based survey among women of Québec (Canada).

PubMed

Blouin-Bougie, Jolyane; Amara, Nabil; Bouchard, Karine; Simard, Jacques; Dorval, Michel

2018-02-27

To identify common and specific individual factors that favour or impede women's interest in and willingness-to-pay (WTP) for breast cancer susceptibility testing (BCST) and to identify the most impactful factors on both outcome measures. This study used a self-administered cross-sectional Web-based questionnaire that included hypothetical scenarios about the availability of a new genetic test for breast cancer. French-speaking women of the general population of Québec (Canada), aged between 35 and 69 years, were identified from a Web-based panel (2410 met the selection criteria, 1160 were reached and 1031 completed the survey). The outcomes are the level of interest in and the range of WTP for BCST. Three categories of individual factors identified in the literature were used as potential explanatory factors, that is, demographic, clinical and psychosocial. Descriptive statistics indicated that the vast majority of sampled women are interested in BCST (90%). Among those, more than half of them are willing-to-pay for such a test (57%). The regression models pointed out several factors associated with both outcomes (eg, age, income, family history, locus of control-powerful others) and marginal effects were used to highlight the most impactful factors for each outcome. The results of this study provide a proxy of the readiness of women of the general population to use and to pay for BCST. They also offer insights for developing inclusive and specific strategies to foster informed decision-making and guide the services offered by health organisations corresponding to women's preferences and needs. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Interfaith Leaders as Social Entrepreneurs

ERIC Educational Resources Information Center

Patel, Eboo; Meyer, Cassie

2012-01-01

Social entrepreneurs work to find concrete solutions to large-scale problems that are scalable and sustainable. In this article, the authors explore what the framework of social entrepreneurship might offer those seeking to positively engage religious diversity on college campuses, and highlight two programs that offer examples of what such…

Creating Poetry.

ERIC Educational Resources Information Center

Drury, John

Encouraging exploration and practice, this book offers hundreds of exercises and numerous tips covering every step involved in creating poetry. Each chapter is a self-contained unit offering an overview of material in the chapter, a definition of terms, and poetry examples from well-known authors designed to supplement the numerous exercises.…

Recent Work with the Transuranium Elements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seaborg, Glenn T.

1958-11-01

In this discussion of the heaviest known elements, the author describes some recent research which appears to offer the most promise for future investigations. As a general background, the author reviews briefly the history and properties of the transuranium elements.

75 FR 51147 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Order Approving the...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-18

....'' \\8\\ The rule requires prominent disclosure of the nature of the conflict, and in certain... Change To Adopt FINRA Rule 5121 (Public Offerings of Securities With Conflicts of Interest) in the... FINRA Rule 5121 (Public Offerings of Securities With Conflicts of Interest) (``Rule'') in the...

Extracurricular Business Planning Competitions: Challenging the Assumptions

ERIC Educational Resources Information Center

Watson, Kayleigh; McGowan, Pauric; Smith, Paul

2014-01-01

Business planning competitions [BPCs] are a commonly offered yet under-examined extracurricular activity. Given the extent of sceptical comment about business planning, this paper offers what the authors believe is a much-needed critical discussion of the assumptions that underpin the provision of such competitions. In doing so it is suggested…

Emergent Learning Focused Teachers and Their Ecological Complexity Worldview

ERIC Educational Resources Information Center

Butler, Joy I.; Storey, Brian; Robson, Claire

2014-01-01

Although Teaching Games for Understanding (TGfU) has gained ground, pedagogical models are sustainable only when situated in a comprehensive worldview and consistent epistemology. After considering the five values orientations offered by Jewett, Bain, and Ennis, the authors conclude that ecological integration offers a useful starting point in…

Afterword: Considerations for Future Practice of Assessment and Accountability

ERIC Educational Resources Information Center

Bresciani, Marilee J.

2013-01-01

This afterword offers challenges and considerations as the assessment movement continues to develop. The author offers some simple considerations for readers to ponder as they advance their evidence-based decision making processes, and encourages others to use these methods within the context of recent neuroscientific evidence that learning and…

Retaining Faculty: A Tale of Two Campuses.

ERIC Educational Resources Information Center

Matier, Michael W.

1990-01-01

A study examining factors influencing the decisions of faculty with firm offers to leave two universities is reported, focusing on the weight and importance faculty give to tangible, intangible, and work-related benefits of the incumbent and offering institutions. Comparisons among institutions and with other related research are made. (Author/MSE)

Maternity and Paternity Policies Available to Academic Librarians

ERIC Educational Resources Information Center

Connell, Ruth Sara

2013-01-01

This study examines how frequently parental leave and other related childcare policies are available to academic librarians across the United States. It also looks at the relationships between policies offered and types of academic libraries that offer those policies. The author surveyed administrators at academic libraries serving baccalaureate,…

77 FR 74283 - Clearing Requirement Determination Under Section 2(h) of the CEA

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-13

... where no DCO offers customer clearing.\\41\\ Freddie Mac requested clarification regarding the legal... represented by London Interbank Offered Rate (LIBOR), and three-month Treasury Bills. LIBOR contains credit... preparing for the move to mandatory clearing. For example, the Japanese Financial Services Authority (JFSA...

Hannelore Wass: Professional Influences and Legacies.

PubMed

Corr, Charles A

2015-01-01

This article offers a reflection on the professional influence of Dr. Hannelore Wass on the author's introduction to and work in the field of death, dying, and bereavement. At the same time, it also offers comments on her broader influence on and legacies left to others who work in this field.

Using Counterfactual History to Enhance Students' Historical Understanding

ERIC Educational Resources Information Center

Roberts, Scott L.

2011-01-01

The question "what if?" has been asked by historians for generations. This article explains how history teachers can use students' own what-if questions to enhance their historical knowledge and understanding by offering educators a step-by-step plan for utilizing counterfactual history into their classrooms. Additionally, the author offers a…

An Anatomy of Authority: The Bologna and ASEM Education Secretariats as Policy Actors and Region Builders

ERIC Educational Resources Information Center

Dang, Que Anh

2018-01-01

This paper examines the sources of authority behind the Bologna and ASEM secretariats' technocratic appearance and administrative routines, and argues that they are transnational policy actors in their own right. By drawing on principal-agent theory and the concept of "authority," it offers an alternative framework for understanding the…

Copyright Ownership in a Networked Multimedia Environment

NASA Technical Reports Server (NTRS)

Williams, Vernon E.

1994-01-01

The explosion of computer communications in the United States has spurred the development of many new technologies. One of these new technologies is Mosaic and the World-Wide Web. Mosaic is a user interface that uses the internet as a backbone for communications. The Mosaic interface enables a user to manipulate text, images and graphics produced by different authors. The flexibility that Mosaic offers raises significant copyright issues. This paper attempts to analyze these issues using current copyright law as a framework. The author then goes on to offer a different analysis that may result from future developments in copyright law.

2015 UK national guideline for the management of infection with Chlamydia trachomatis.

PubMed

Nwokolo, Nneka C; Dragovic, Bojana; Patel, Sheel; Tong, C Y William; Barker, Gary; Radcliffe, Keith

2016-03-01

This guideline offers recommendations on the diagnostic tests, treatment regimens and health promotion principles needed for the effective management of Chlamydia trachomatis genital infection. It covers the management of the initial presentation, as well the prevention of transmission and future infection. The guideline is aimed at individuals aged 16 years and older presenting to healthcare professionals working in departments offering Level 3 care in sexually transmitted infections management within the UK. However, the principles of the recommendations should be adopted across all levels, using local care pathways where appropriate. © The Author(s) 2016.

Self-ratings of physical attractiveness in a competitive context: when males are more sensitive to self-perceptions than females.

PubMed

Saad, Gad; Gill, Tripat

2009-10-01

The authors investigated sex differences in the ratings of physical attractiveness in a competitive context. Participants in an Ultimatum Game experiment offered to split a sum of money with their opponents who could either accept or reject the offers; subsequently, physical attractiveness ratings (both self-ratings and of the other) were obtained. The authors found that male participants rated themselves higher on physical attractiveness when facing male opponents than when facing female ones; there was no such difference for the female participants. Furthermore, male participants' self-ratings of physical attractiveness were higher than the ratings provided by their corresponding male opponents. The authors discuss these findings using the tenets of evolutionary psychology pertaining to as male intra-sexual rivalry in competitive contexts.

47 CFR 0.261 - Authority delegated.

Code of Federal Regulations, 2010 CFR

2010-10-01

... training program for foreign officials offered through the U.S. Telecommunications Training Institute; (12... forfeitures pursuant to section 203 or section 503(b) of the Communications Act of 1934, as amended, in... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Delegations of Authority...

47 CFR 0.261 - Authority delegated.

Code of Federal Regulations, 2014 CFR

2014-10-01

... for foreign officials offered through the U.S. Telecommunications Training Institute; (12) In... or section 503(b) of the Communications Act of 1934, as amended, in amounts of more than $80,000 for... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Delegations of Authority...

47 CFR 0.261 - Authority delegated.

Code of Federal Regulations, 2011 CFR

2011-10-01

... training program for foreign officials offered through the U.S. Telecommunications Training Institute; (12... forfeitures pursuant to section 203 or section 503(b) of the Communications Act of 1934, as amended, in... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Delegations of Authority...

47 CFR 0.261 - Authority delegated.

Code of Federal Regulations, 2012 CFR

2012-10-01

... for foreign officials offered through the U.S. Telecommunications Training Institute; (12) In... or section 503(b) of the Communications Act of 1934, as amended, in amounts of more than $80,000 for... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Delegations of Authority...

47 CFR 0.261 - Authority delegated.

Code of Federal Regulations, 2013 CFR

2013-10-01

... for foreign officials offered through the U.S. Telecommunications Training Institute; (12) In... or section 503(b) of the Communications Act of 1934, as amended, in amounts of more than $80,000 for... Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Delegations of Authority...

Social Institutions and Nuclear Energy

ERIC Educational Resources Information Center

Weinberg, Alvin M.

1972-01-01

Nuclear technologists can offer an all but infinite source of relatively cheap and clean energy" but society must decide whether the price of eternal vigilance needed to ensure proper and safe operation of its nuclear energy system" is worth the benefits. (Author/AL)

Three Big Ideas for Reforming Acquisition: Evidence-Based Propositions for Transformation

DTIC Science & Technology

2015-04-30

specific ideas for improving key aspects of defense acquisition reforming the process for managing capabilities, addressing technology insertion, and...offers three specific ideas for improving key aspects of defense acquisition: reforming the process for managing capabilities, addressing technology...and process changes need to be made for any significant change to be seen. This paper offers reform ideas in three specific areas: achieving the

Foods and Beverages Available at SNAP-Authorized Drugstores in Sections of North Carolina.

PubMed

Racine, Elizabeth F; Kennedy, Ashley; Batada, Ameena; Story, Mary

2017-09-01

To assess healthy food availability in Supplemental Nutrition Assistance Program-authorized drugstores by store chain and neighborhood income level in 3 regions of North Carolina. Cross-sectional, descriptive study. Twenty-five counties in North Carolina. A total of 108 drugstores (36 CVS Health, 36 Rite Aid, and 36 Walgreens). Fifty foods and beverages offered at drugstores, categorized as healthier and less healthy. Kruskal-Wallis tests were used to test differences in the availability of foods and beverages by chain and neighborhood income. Of the 50 foods/beverages observed, 11 were available at all drugstores. Three of the 36 (8%) healthier items were available at all stores (100% fruit juice, water, and high-fiber cereal) whereas 8 of the 14 less healthy items (57%) were available at all stores (chips, sports drinks, energy drinks, regular soda, diet soda, sugar-sweetened beverages, beer, and wine). Only 3% of drugstores offered fresh vegetables and 4% offered fresh fruits. Less than 20% offered frozen chicken or beef. For 36 healthier foods, 11 differed by chain (28%); for less healthy foods 2 of 14 differed by chain (7%). Foods and beverages offered did not vary by neighborhood income. Although drugstores offer some healthier items, few offer fresh produce. As the drugstore industry changes, it is important for the nutrition community to study the impact of these changes on food purchasing behavior and ultimately health. Copyright © 2017 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved.

Neural basis of increased costly norm enforcement under adversity.

PubMed

Wu, Yan; Yu, Hongbo; Shen, Bo; Yu, Rongjun; Zhou, Zhiheng; Zhang, Guoping; Jiang, Yushi; Zhou, Xiaolin

2014-12-01

Humans are willing to punish norm violations even at a substantial personal cost. Using fMRI and a variant of the ultimatum game and functional magnetic resonance imaging, we investigated how the brain differentially responds to fairness in loss and gain domains. Participants (responders) received offers from anonymous partners indicating a division of an amount of monetary gain or loss. If they accept, both get their shares according to the division; if they reject, both get nothing or lose the entire stake. We used a computational model to derive perceived fairness of offers and participant-specific inequity aversion. Behaviorally, participants were more likely to reject unfair offers in the loss (vs gain) domain. Neurally, the positive correlation between fairness and activation in ventral striatum was reduced, whereas the negative correlations between fairness and activations in dorsolateral prefrontal cortex were enhanced in the loss domain. Moreover, rejection-related dorsal striatum activation was higher in the loss domain. Furthermore, the gain-loss domain modulates costly punishment only when unfair behavior was directed toward the participants and not when it was directed toward others. These findings provide neural and computational accounts of increased costly norm enforcement under adversity and advanced our understanding of the context-dependent nature of fairness preference. © The Author (2014). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

Texas Medication Algorithm Project, phase 3 (TMAP-3): rationale and study design.

PubMed

Rush, A John; Crismon, M Lynn; Kashner, T Michael; Toprac, Marcia G; Carmody, Thomas J; Trivedi, Madhukar H; Suppes, Trisha; Miller, Alexander L; Biggs, Melanie M; Shores-Wilson, Kathy; Witte, Bradley P; Shon, Steven P; Rago, William V; Altshuler, Kenneth Z

2003-04-01

Medication treatment algorithms may improve clinical outcomes, uniformity of treatment, quality of care, and efficiency. However, such benefits have never been evaluated for patients with severe, persistent mental illnesses. This study compared clinical and economic outcomes of an algorithm-driven disease management program (ALGO) with treatment-as-usual (TAU) for adults with DSM-IV schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD) treated in public mental health outpatient clinics in Texas. The disorder-specific intervention ALGO included a consensually derived and feasibility-tested medication algorithm, a patient/family educational program, ongoing physician training and consultation, a uniform medical documentation system with routine assessment of symptoms and side effects at each clinic visit to guide ALGO implementation, and prompting by on-site clinical coordinators. A total of 19 clinics from 7 local authorities were matched by authority and urban status, such that 4 clinics each offered ALGO for only 1 disorder (SCZ, BD, or MDD). The remaining 7 TAU clinics offered no ALGO and thus served as controls (TAUnonALGO). To determine if ALGO for one disorder impacted care for another disorder within the same clinic ("culture effect"), additional TAU subjects were selected from 4 of the ALGO clinics offering ALGO for another disorder (TAUinALGO). Patient entry occurred over 13 months, beginning March 1998 and concluding with the final active patient visit in April 2000. Research outcomes assessed at baseline and periodically for at least 1 year included (1) symptoms, (2) functioning, (3) cognitive functioning (for SCZ), (4) medication side effects, (5) patient satisfaction, (6) physician satisfaction, (7) quality of life, (8) frequency of contacts with criminal justice and state welfare system, (9) mental health and medical service utilization and cost, and (10) alcohol and substance abuse and supplemental substance use information. Analyses were based on hierarchical linear models designed to test for initial changes and growth in differences between ALGO and TAU patients over time in this matched clinic design.

Segmented assimilation theory and the life model: an integrated approach to understanding immigrants and their children.

PubMed

Piedra, Lissette M; Engstrom, David W

2009-07-01

The life model offers social workers a promising framework to use in assisting immigrant families. However, the complexities of adaptation to a new country may make it difficult for social workers to operate from a purely ecological approach. The authors use segmented assimilation theory to better account for the specificities of the immigrant experience. They argue that by adding concepts from segmented assimilation theory to the life model, social workers can better understand the environmental stressors that increase the vulnerabilities of immigrants to the potentially harsh experience of adapting to a new country. With these concepts, social workers who work with immigrant families will be better positioned to achieve their central goal: enhancing person and environment fit.

Generation of six multiple sclerosis patient-derived induced pluripotent stem cell lines.

PubMed

Miquel-Serra, L; Duarri, A; Muñoz, Y; Kuebler, B; Aran, B; Costa, C; Martí, M; Comabella, M; Malhotra, S; Montalban, X; Veiga, A; Raya, A

2017-10-01

Multiple sclerosis (MS) is considered a chronic autoimmune disease of the central nervous system that leads to gliosis, demyelination, axonal damage and neuronal death. The MS disease aetiology is unknown, though a polymorphism of the TNFRSF1A gene, rs1800693, is known to confer an increased risk for MS. Using retroviral delivery of reprogramming transgenes, we generated six MS patient-specific iPSC lines with two distinct genotypes, CC or TT, of the polymorphism rs1800693. iPSC lines had normal karyotype, expressed pluripotency genes and differentiated into the three germ layers. These lines offer a good tool to study MS pathomechanisms and for drug testing. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

Critical Medical Anthropology in Midwifery Research

PubMed Central

Newnham, Elizabeth C.; Pincombe, Jan I.; McKellar, Lois V.

2016-01-01

In this article, we discuss the use of critical medical anthropology (CMA) as a theoretical framework for research in the maternity care setting. With reference to the doctoral research of the first author, we argue for the relevance of using CMA for research into the maternity care setting, particularly as it relates to midwifery. We then give an overview of an existing analytic model within CMA that we adapted for looking specifically at childbirth practices and which was then used in both analyzing the data and structuring the thesis. There is often no clear guide to the analysis or writing up of data in ethnographic research; we therefore offer this Critical analytic model of childbirth practices for other researchers conducting ethnographic research into childbirth or maternity care. PMID:28462347

[Do Italian university birthing centers promote starting breast-feeding?].

PubMed

Donati, Serena; Andreozzi, Silvia; Grandolfo, Michele E

2003-01-01

This study reports the results of an Italian sampling survey carried out in 1999 on the evaluation of the support and the information activities offered to women who delivered with specific regard to breast-feeding. 1986 women have been interviewed. The response rate was 95%. Ninety-four percent of the sample reported a positive attitude among breast-feeding, but only 80% breastfed her baby during hospital stay. Moreover only 31% had the opportunity to start breast-feeding immediately after birth. Around 50% of women reported the quality of the hospital support as inadequate. The authors conclude that, even in the light of the present Italian law, much more could and should be done in order to promote and support women in breast-feeding.

Transient thermal state of an active Braille matrix with incorporated thermal actuators by means of finite element method.

PubMed

Aluţei, Alexandra-Maria; Szelitzky, Emoke; Mândru, Dan

2013-01-01

In this article the authors present the transient thermal analysis for a developed thermal linear actuator based on wax paraffin used to drive the cells of a Braille device. A numerical investigation of transient heat transfer phenomenon during paraffin melting and solidification in an encapsulated recipient has been carried out using the ANSYS v.12 software. The researchers offer data on the heat distribution in the proposed model of the actuator as well as on the material properties required for these applications and provide the opportunity to identify new problems specific to thermal actuation, such as the heater properties and the cooling process of the active material in the structure of the Braille cell.

Depression and Anxiety During Pregnancy: Evaluating the Literature in Support of Clinical Risk-Benefit Decision-Making.

PubMed

Dalke, Katharine Baratz; Wenzel, Amy; Kim, Deborah R

2016-06-01

Depression and anxiety during pregnancy are common, and patients and providers are faced with complex decisions regarding various treatment modalities. A structured discussion of the risks and benefits of options with the patient and her support team is recommended to facilitate the decision-making process. This clinically focused review, with emphasis on the last 3 years of published study data, evaluates the major risk categories of medication treatments, namely pregnancy loss, physical malformations, growth impairment, behavioral teratogenicity, and neonatal toxicity. Nonpharmacological treatment options, including neuromodulation and psychotherapy, are also briefly reviewed. Specific recommendations, drawn from the literature and the authors' clinical experience, are also offered to help guide the clinician in decision-making.

Egg serpins: The chicken and/or the egg dilemma.

PubMed

Dombre, Clara; Guyot, Nicolas; Moreau, Thierry; Monget, Philippe; Da Silva, Mylène; Gautron, Joël; Réhault-Godbert, Sophie

2017-02-01

Twenty-seven serpins belonging to clade A, B, C, D, E, F, G, H and I serpins are currently referenced in chicken genome databases. Phylogenetic analysis of chicken serpins revealed that ovalbumin (Serpinb14) and its paralogs ovalbumin-related protein Y (Serpinb14b) and ovalbumin-related protein X (Serpinb14c) are found in bird species. These clade B serpins are specifically expressed in reproductive tissues and exported in the egg where they constitute major protein components. These data suggest that these three paralogs have probably appeared in birds to face new environments and ensure the extra-uterine development of an embryo in a shell egg. Twelve other serpins have been identified in the newly produced egg, some of them having a specific distribution in the respective egg structures (eggshell, egg white, vitelline membrane and egg yolk). The physiological role of these egg serpins remain largely unexplored, but there is increasing evidence in literature or by homologies with their mammalian counterparts, that some of them participate in cell proliferation, tissue remodeling and/or angiogenesis associated with folliculogenesis and development of extraembryonic structures, eggshell biomineralization, egg defense and nutrition of the embryo. A better knowledge of the phylogenetic evolution of these 15 serpins in other oviparous species, on their egg distribution, on their regulation during embryonic development (activation/degradation/transfer) and on their functional specificity, is needed to better appreciate their role and their bird-specificity. These review shed light on the multiple possibilities that offer the avian egg model to study the role of serpins in reproduction and developmental biology. Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Is an ecosystem services-based approach developed for setting specific protection goals for plant protection products applicable to other chemicals?

PubMed

Maltby, Lorraine; Jackson, Mathew; Whale, Graham; Brown, A Ross; Hamer, Mick; Solga, Andreas; Kabouw, Patrick; Woods, Richard; Marshall, Stuart

2017-02-15

Clearly defined protection goals specifying what to protect, where and when, are required for designing scientifically sound risk assessments and effective risk management of chemicals. Environmental protection goals specified in EU legislation are defined in general terms, resulting in uncertainty in how to achieve them. In 2010, the European Food Safety Authority (EFSA) published a framework to identify more specific protection goals based on ecosystem services potentially affected by plant protection products. But how applicable is this framework to chemicals with different emission scenarios and receptor ecosystems? Four case studies used to address this question were: (i) oil refinery waste water exposure in estuarine environments; (ii) oil dispersant exposure in aquatic environments; (iii) down the drain chemicals exposure in a wide range of ecosystems (terrestrial and aquatic); (iv) persistent organic pollutant exposure in remote (pristine) Arctic environments. A four-step process was followed to identify ecosystems and services potentially impacted by chemical emissions and to define specific protection goals. Case studies demonstrated that, in principle, the ecosystem services concept and the EFSA framework can be applied to derive specific protection goals for a broad range of chemical exposure scenarios. By identifying key habitats and ecosystem services of concern, the approach offers the potential for greater spatial and temporal resolution, together with increased environmental relevance, in chemical risk assessments. With modifications including improved clarity on terminology/definitions and further development/refinement of the key concepts, we believe the principles of the EFSA framework could provide a methodical approach to the identification and prioritization of ecosystems, ecosystem services and the service providing units that are most at risk from chemical exposure. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Negotiating for more: the multiple equivalent simultaneous offer.

PubMed

Heller, Richard E

2014-02-01

Whether a doctor, professional baseball manager, or a politician, having successful negotiation skills is a critical part of being a leader. Building upon prior journal articles on negotiation strategy, the author presents the concept of the multiple equivalent simultaneous offer (MESO). The concept of a MESO is straightforward: as opposed to making a single offer, make multiple offers with several variables. Each offer alters the different variables, such that the end result of each offer is equivalent from the perspective of the party making the offer. Research has found several advantages to the use of MESOs. For example, using MESOs, an offer was more likely to be accepted, and the counterparty was more likely to be satisfied with the negotiated deal. Additional benefits have been documented as well, underscoring why a prepared radiology business leader should understand the theory and practice of MESO. Copyright © 2014 American College of Radiology. Published by Elsevier Inc. All rights reserved.

Guidelines for Nonsexist Language in APA Journals: Publication Manual Change Sheet 2

ERIC Educational Resources Information Center

American Psychologist, 1977

1977-01-01

This second change sheet for its publication manual states the American Psychologist Association's policy on sexist language in its journals offers some general principles for journal authors to consider, and suggests some ways to avoid sexist language. (Author)

Writing Away from Fear: Mina Shaughnessy and the Uses of Authority.

ERIC Educational Resources Information Center

Allen, Michael

1980-01-01

Responds to John Rouse's attack on Mina Shaughnessy's teaching strategies for composition instruction (see EJ 209 264). Offers personal experiences to illustrate the role of the basic writing teacher and the uses of authority in the basic writing classroom. (JT)

Who's Who in Postsecondary Institutions?

ERIC Educational Resources Information Center

Kezar, Adrianna; Frank, Vikki; Lester, Jaime; Yang, Hannah

2009-01-01

In this document the authors provide practitioners offering education Independent Development Accounts (IDAs) with information about whom to partner with in a postsecondary institution. The authors gained this information through interviews, focus groups, and case studies with higher education and IDA practitioners. College campuses can sometimes…

Gestalt Therapy Interventions for Group Counseling

ERIC Educational Resources Information Center

Passons, William R.

1972-01-01

The author offers a brief introduction to some of the basic tenets of Gestalt therapy, noting goals that are similar to those in counseling theories. He also suggests several interventions from Gestalt therapy to be considered for group counseling and discusses their applications. (Author)

Carbon dioxide recycling

EPA Science Inventory

The recycling of carbon dioxide to methanol and dimethyl ether is seen to offer a substantial route to renewable and environmentally carbon neutral fuels. One of the authors has championed the “Methanol Economy" in articles and a book. By recycling ambient CO2, the authors argue ...

Learned Helplessness: A Model to Understand and Overcome a Child's Extreme Reaction to Failure.

ERIC Educational Resources Information Center

Balk, David

1983-01-01

The author reviews literature on childrens' reactions to perceived failure and offers "learned helplessness" as a model to explain why a child who makes a mistake gives up. Suggestions for preventing these reactions are given. (Author/JMK)

12 CFR 230.1 - Authority, purpose, coverage, and effect on state laws.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Authority, purpose, coverage, and effect on..., and effect on state laws. (a) Authority. This part, known as Regulation DD, is issued by the Board of... advertising rules in § 230.8 of this part apply to any person who advertises an account offered by a...

Evaluation of scientific output in Dentistry in Spanish Universities.

PubMed

De la Flor-Martínez, M; Galindo-Moreno, P; Sánchez-Fernández, E; Abadal, E; Cobo, M-J; Herrera-Viedma, E

2017-07-01

The aim of this study was to assess the scientific output of Spanish universities that offer a bachelor's degree in dentistry through the use of various bibliometric indicators. A total of 21 universities offered a bachelor's degree in dentistry in academic year 2016-2017. The search for papers published by authors associated with these institutions was carried out using the selection of journals listed in the Journal Citation Reports (JCR) and the Web of Knowledge database for the period 1986-2017. On the basis of these data, we determined the output, the h-, g- and hg-indexes, the most productive authors, international collaborations, and the most relevant journals. Public universities obtained better results than private universities. The University of Valencia was ranked first, followed by the Complutense University of Madrid and the University of Granada. The most productive author was José Vicente Bagán, but the author with the highest h-index was Mariano Sanz and Manuel Toledado. The universities with the greatest output and highest citation rates had more international collaborations. The most developed fields in Spanish universities were Oral surgery, Oral medicine and Dental materials. The universities had different models of production. At universities such as Barcelona or Valencia, the production was focused on very few departments and authors. At the other extreme, the University of Granada had various sources of research and authors, which meant that its output and citation rate could increase more. University faculties must provide suitable academic and research training, and therefore must be assessed using objective criteria and bibliometric tools. Although the number of university schools and faculties that teach dentistry has increased, and particularly the number of private universities, there is no correlation between their quality and output and the number of places offered on their courses.

75 FR 31825 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-04

....'' \\5\\ The rule requires prominent disclosure of the nature of the conflict, and in certain... Change To Adopt FINRA Rule 5121 (Public Offerings of Securities With Conflicts of Interest) in the... (Public Offerings of Securities With Conflicts of Interest) as a FINRA rule in the consolidated FINRA...

47 CFR 25.129 - Equipment authorization for portable earth-station transceivers.

Code of Federal Regulations, 2011 CFR

2011-10-01

... equipment certification procedure in part 2, Subpart J of this chapter for importation, sale or lease in the United States, or offer, shipment, or distribution for sale or lease in the United States of portable..., to devices imported, sold, leased, or offered, shipped, or distributed for sale or lease before...

Fostering Academic Creativity in Gifted Students. ERIC Digest #E484.

ERIC Educational Resources Information Center

Torrance, E. Paul; Goff, Kathy

This digest describes academic creativity and offers suggestions for its development in gifted students. Creative learning and learning by authority are contrasted and examples of each are given. The naturally creative behavior of young children is noted. Among suggestions offered to teachers are: respect the unusual questions of children; show…

77 FR 35457 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-13

... eliminating the Original Proposal's requirement for members to disclose to investors the anticipated use of... investor prior to sale the anticipated use of offering proceeds, and the amount and type of offering... investor a separate disclosure document containing this information. The Original Proposal also would have...

COOCs over MOOCs

ERIC Educational Resources Information Center

Horton, Howard E.

2013-01-01

Massive open online courses (MOOCs) are all the rage these days and are being offered as a potential way to shorten the degree-attainment process and thereby reduce costs. At New England College of Business and Finance (NECB), staff focus on what the author likes to call "classically offered online classes" or COOCs, instead of MOOCs.…

75 FR 54464 - Delegation of Authority to the Director of Its Division of Enforcement

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-08

... Division of Enforcement, in connection with the collection of delinquent debts arising from actions to enforce the federal securities laws, to terminate collection activity or discharge debts, to accept or reject offers to compromise debts, and to accept or reject offers to enter into payment plans. This...

Introduction to Communication, Grades PreK-2. The Math Process Standards Series

ERIC Educational Resources Information Center

O'Connell, Susan; O'Connor, Kelly

2007-01-01

In this book, the authors offer suggestions for teachers to help students explore, express, and better understand mathematical content through talking and writing. They offer an array of entry points for understanding, planning, and teaching, including strategies that help students put their ideas into words, clarify them, elaborate on them, and…

Nakem Pedagogy: Social Biography in Liberatory Education

ERIC Educational Resources Information Center

Acido, Jeffrey Tangonan

2016-01-01

In this article, the author offers the genealogy of his articulation of an emerging pedagogical praxis. He offers, through his discussion of "Nakem" Pedagogy, the profound realization that comes from one's story--a story in itself, not simply a story as a tool or medium, but a story as empirical evidence of one's ontological becoming--an…

Critical Race Theory and Research on Asian Americans and Pacific Islanders in Higher Education

ERIC Educational Resources Information Center

Teranishi, Robert T.; Behringer, Laurie B.; Grey, Emily A.; Parker, Tara L.

2009-01-01

In this article, the authors offer critical race theory (CRT) as an alternative theoretical perspective that permits the examination and transcendence of conceptual blockages, while simultaneously offering alternative perspectives on higher education policy and practice and the Asian American and Pacific Islander (AAPI) student population. The…

Humanistic Wellness Services for Community Mental Health Providers

ERIC Educational Resources Information Center

Carney, Jolynn V.

2007-01-01

The author examines the unique ability of mental health providers to offer humanistic services in a highly competitive atmosphere by using a wellness approach. J. E. Myers and T. J. Sweeney's (2005) 5 second-order factors are offered as a conceptual model. Therapeutic techniques and humanizing benefits for individuals, families, and communities…

38 CFR 21.7620 - Courses included in programs of education.

Code of Federal Regulations, 2011 CFR

2011-07-01

... learning offers the course for credit toward the standard college degree the reservist is pursuing; or (ii... reflect educational attainment and must be offered by an institution of higher learning. (Authority: 38 U... restrictions found in paragraph (c)(1) of this section, effective October 29, 1992, VA may pay educational...

38 CFR 21.7620 - Courses included in programs of education.

Code of Federal Regulations, 2013 CFR

2013-07-01

... learning offers the course for credit toward the standard college degree the reservist is pursuing; or (ii... reflect educational attainment and must be offered by an institution of higher learning. (Authority: 38 U... restrictions found in paragraph (c)(1) of this section, effective October 29, 1992, VA may pay educational...

38 CFR 21.7620 - Courses included in programs of education.

Code of Federal Regulations, 2014 CFR

2014-07-01

... learning offers the course for credit toward the standard college degree the reservist is pursuing; or (ii... reflect educational attainment and must be offered by an institution of higher learning. (Authority: 38 U... restrictions found in paragraph (c)(1) of this section, effective October 29, 1992, VA may pay educational...

38 CFR 21.7620 - Courses included in programs of education.

Code of Federal Regulations, 2010 CFR

2010-07-01

... learning offers the course for credit toward the standard college degree the reservist is pursuing; or (ii... reflect educational attainment and must be offered by an institution of higher learning. (Authority: 38 U... restrictions found in paragraph (c)(1) of this section, effective October 29, 1992, VA may pay educational...

38 CFR 21.7620 - Courses included in programs of education.

Code of Federal Regulations, 2012 CFR

2012-07-01

... learning offers the course for credit toward the standard college degree the reservist is pursuing; or (ii... reflect educational attainment and must be offered by an institution of higher learning. (Authority: 38 U... restrictions found in paragraph (c)(1) of this section, effective October 29, 1992, VA may pay educational...

28 CFR 0.162 - Offers which may be rejected by Assistant Attorneys General.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Attorneys General. 0.162 Section 0.162 Judicial Administration DEPARTMENT OF JUSTICE ORGANIZATION OF THE..., Penalties, and Forfeitures § 0.162 Offers which may be rejected by Assistant Attorneys General. Each Assistant Attorney General is authorized, with respect to matters assigned to his division or office, to...

Give Your Technology Program a Little "Class"!

ERIC Educational Resources Information Center

Vengersammy, Ormilla

2009-01-01

The Orange County Library System (OCLS) began to offer basic technology classes in July 2000. The computers were funded through a grant awarded by the Bill & Melinda Gates Foundation. Over time, the library staff noticed that the demand for the classes increased, so the offering of classes also increased. When the author arrived at OCLS, her…

Homeland Security Education: Managerial versus Nonmanagerial Market Perspectives of an Academic Program

ERIC Educational Resources Information Center

Doss, Daniel; Henley, Russ; McElreath, David; Lackey, Hilliard; Jones, Don; Gokaraju, Balakrishna; Sumrall, William

2016-01-01

The authors discuss the findings of a market study that preceded the offering of an academic program in homeland security. The university disseminated a mail survey to gain data for analysis of variance testing of several hypotheses regarding market perceptions of the intended homeland security program offering. Stratification involved segregating…

Principles and Practices of the Circle of Trust[R] Approach

ERIC Educational Resources Information Center

Chadsey, Terry; Jackson, Marcy

2012-01-01

Through the Center for Courage & Renewal, the authors offer personal and professional retreats and programs designed to explore vocational and life questions, offer renewal and encouragement, and deepen engagement in professional practice. Using what they call the Circle of Trust[R] approach, they invite groups into a communal process based upon a…

No Light at the End of Tunnel Vision: Steps for Improving Lesson Plans

ERIC Educational Resources Information Center

Dunn, Rita; Craig, Martin; Favre, Lois; Markus, Doron; Pedota, Paul; Sookdeo, Gale; Stock, Jessica; Terry, Brian

2010-01-01

The authors of this article believe that the current structure of lesson plans impede differentiation, individualization, and innovation and offer little in assessing the quality of teaching and learning. Concrete steps will be offered for planning to better respond to student diversity in meeting lesson objectives. (Contains 1 figure.)

The School Store: Learning by Involvement--part 1

ERIC Educational Resources Information Center

Levinson, Lawrence

1974-01-01

If the school store carries suitable product lines, presents them attractively, accommodates the flow of customers, and brings in sufficient sales, it can offer many--if not more--of the learning experiences offered by a good cooperative work station as it relates store operations, merchandising, sales promotion, and financial control. (Author/AG)

Fabrication of Micropatterned Dipeptide Hydrogels by Acoustic Trapping of Stimulus-Responsive Coacervate Droplets.

PubMed

Nichols, Madeleine K; Kumar, Ravinash Krishna; Bassindale, Philip G; Tian, Liangfei; Barnes, Adrian C; Drinkwater, Bruce W; Patil, Avinash J; Mann, Stephen

2018-06-01

Acoustic standing waves offer an excellent opportunity to trap and spatially manipulate colloidal objects. This noncontact technique is used for the in situ formation and patterning in aqueous solution of 1D or 2D arrays of pH-responsive coacervate microdroplets comprising poly(diallyldimethylammonium) chloride and the dipeptide N-fluorenyl-9-methoxy-carbonyl-D-alanine-D-alanine. Decreasing the pH of the preformed droplet arrays results in dipeptide nanofilament self-assembly and subsequent formation of a micropatterned supramolecular hydrogel that can be removed as a self-supporting monolith. Guest molecules such as molecular dyes, proteins, and oligonucleotides are sequestered specifically within the coacervate droplets during acoustic processing to produce micropatterned hydrogels containing spatially organized functional components. Using this strategy, the site-specific isolation of multiple enzymes to drive a catalytic cascade within the micropatterned hydrogel films is exploited. © 2018 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Apollo by the Numbers: A Statistical Reference

NASA Technical Reports Server (NTRS)

Orloff, Richard; Garber, Stephen (Technical Monitor)

2000-01-01

The purpose of this work is to provide researchers, students, and space enthusiasts with a comprehensive reference for facts about Project Apollo, America's effort to put humans in the Moon. Research for this work started in 1988, when the author discovered that, despite the number of excellent books that focused on the drama of events that highlighted Apollo, there were none that focused on the drama of the numbers. This book is separated into two parts. The first part contains narratives for the Apollo 1 fire and the 11 flown Apollo missions. Included after each narrative is a series of data tables, followed by a comprehensive timeline of events from just before liftoff to just after crew and spacecraft recovery. The second part contains more than 50 tables. These tables organize much of the data from the narratives in one place so they can be compared among all missions. The tables offer additional data as well. The reader can select a specific mission narrative or specific data table by consulting the Table of Contents.

Semantic embodiment, disembodiment or misembodiment? In search of meaning in modules and neuron circuits.

PubMed

Pulvermüller, Friedemann

2013-10-01

"Embodied" proposals claim that the meaning of at least some words, concepts and constructions is grounded in knowledge about actions and objects. An alternative "disembodied" position locates semantics in a symbolic system functionally detached from sensorimotor modules. This latter view is not tenable theoretically and has been empirically falsified by neuroscience research. A minimally-embodied approach now claims that action-perception systems may "color", but not represent, meaning; however, such minimal embodiment (misembodiment?) still fails to explain why action and perception systems exert causal effects on the processing of symbols from specific semantic classes. Action perception theory (APT) offers neurobiological mechanisms for "embodied" referential, affective and action semantics along with "disembodied" mechanisms of semantic abstraction, generalization and symbol combination, which draw upon multimodal brain systems. In this sense, APT suggests integrative-neuromechanistic explanations of why both sensorimotor and multimodal areas of the human brain differentially contribute to specific facets of meaning and concepts. Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

Digital images are data: and should be treated as such.

PubMed

Cromey, Douglas W

2013-01-01

The scientific community has become very concerned about inappropriate image manipulation. In journals that check figures after acceptance, 20-25% of the papers contained at least one figure that did not comply with the journal's instructions to authors. The scientific press continues to report a small, but steady stream of cases of fraudulent image manipulation. Inappropriate image manipulation taints the scientific record, damages trust within science, and degrades science's reputation with the general public. Scientists can learn from historians and photojournalists, who have provided a number of examples of attempts to alter or misrepresent the historical record. Scientists must remember that digital images are numerically sampled data that represent the state of a specific sample when examined with a specific instrument. These data should be carefully managed. Changes made to the original data need to be tracked like the protocols used for other experimental procedures. To avoid pitfalls, unexpected artifacts, and unintentional misrepresentation of the image data, a number of image processing guidelines are offered.

Digital Images Are Data: And Should Be Treated as Such

PubMed Central

Cromey, Douglas W.

2014-01-01

The scientific community has become very concerned about inappropriate image manipulation. In journals that check figures after acceptance, 20–25% of the papers contained at least one figure that did not comply with the journal’s instructions to authors. The scientific press continues to report a small, but steady stream of cases of fraudulent image manipulation. Inappropriate image manipulation taints the scientific record, damages trust within science, and degrades science’s reputation with the general public. Scientists can learn from historians and photojournalists, who have provided a number of examples of attempts to alter or misrepresent the historical record. Scientists must remember that digital images are numerically sampled data that represent the state of a specific sample when examined with a specific instrument. These data should be carefully managed. Changes made to the original data need to be tracked like the protocols used for other experimental procedures. To avoid pitfalls, unexpected artifacts, and unintentional misrepresentation of the image data, a number of image processing guidelines are offered. PMID:23026995

A survey of the use of complementary and alternative medicine in Illinois hospice and palliative care organizations.

PubMed

Van Hyfte, Gregory J; Kozak, Leila E; Lepore, Michael

2014-08-01

This research assesses complementary and alternative medicine (CAM) use and administration for patients and family caregivers in Illinois hospice and palliative care organizations. An online survey was administered to a sample of 108 contacts of Illinois organizations listed in the National Hospice and Palliative Care Organization website, and 90.3% of the responding organizations offered some type of CAM. The top 5 most frequently offered CAM modalities to patients were pet therapy (64.5%), music therapy (61.3%), massage therapy (54.8%), art therapy (29.0%), and energy therapies (25.8%); these were the same top 5 offered to families but with different frequencies. Findings regarding utilization, administration, financing, and spiritual/cultural competency are discussed with policy recommendations for data collection, administrative improvements, and integration of CAM providers into service delivery. © The Author(s) 2013.

Understanding customer reactions to brokered ultimatums: applying negotiation and justice theory.

PubMed

Humphrey, Stephen E; Ellis, Aleksander P J; Conlon, Donald E; Tinsley, Catherine H

2004-06-01

There has been little research examining customer reactions to brokered ultimatum game (BUG) contexts (i.e. exchanges in which 1 party offers an ultimatum price for a resource through an intermediary, and the ultimatum offer is accepted or rejected by the other party). In this study, the authors incorporated rational decision-making theory and justice theory to examine how customers' bids, recommendations, and repatronage behavior are affected by characteristics of BUG contexts (changing from an ultimatum to negotiation transaction, response timeliness, and offer acceptance or rejection). Results indicated that customers attempt to be economically efficient with their bidding behavior. However, negotiation structures, long waits for a response, and rejected bids create injustice perceptions (particularly informational and distributive injustice), negatively influencing customers' recommendations to others and their repatronage. The authors then discuss the practical and theoretical implications of their results. (c) 2004 APA

Nurse practitioners and controlled substances prescriptive authority: improving access to care.

PubMed

Ambrose, Michelle A; Tarlier, Denise S

2013-03-01

In 2007, Health Canada proposed a new framework to regulate prescriptive authority for controlled substances, titled New Classes of Practitioners Regulations (NCPR). The new regulatory framework was passed in November 2012; it gives nurse practitioners (NPs), midwives and podiatrists the authority to prescribe controlled medications under the Controlled Drugs and Substances Act. It is expected that authorizing NPs to write prescriptions for certain controlled substances commonly used in primary care will enhance flexibility and timeliness in primary care service delivery. Studies from the United States have shown positive outcomes in primary care access, decreased healthcare costs and the evolution and advancement of the NP role when prescriptive authority was expanded to include controlled substances. The purpose of this paper is to examine how NPs' prescriptive authority for controlled substances affects access to primary care and NP role development. Three key issues identified from the experience of one group of NPs in the United States (access to care, professional autonomy and prescriber knowledge) offer insight into the practice changes that may be anticipated for NPs in Canada now that they have acquired prescriptive authority for controlled substances. Recommendations are offered to assist nurse leaders and educators to best support NPs as they take on this new and important role responsibility.

The Use of Cronbach's Alpha When Developing and Reporting Research Instruments in Science Education

NASA Astrophysics Data System (ADS)

Taber, Keith S.

2017-06-01

Cronbach's alpha is a statistic commonly quoted by authors to demonstrate that tests and scales that have been constructed or adopted for research projects are fit for purpose. Cronbach's alpha is regularly adopted in studies in science education: it was referred to in 69 different papers published in 4 leading science education journals in a single year (2015)—usually as a measure of reliability. This article explores how this statistic is used in reporting science education research and what it represents. Authors often cite alpha values with little commentary to explain why they feel this statistic is relevant and seldom interpret the result for readers beyond citing an arbitrary threshold for an acceptable value. Those authors who do offer readers qualitative descriptors interpreting alpha values adopt a diverse and seemingly arbitrary terminology. More seriously, illustrative examples from the science education literature demonstrate that alpha may be acceptable even when there are recognised problems with the scales concerned. Alpha is also sometimes inappropriately used to claim an instrument is unidimensional. It is argued that a high value of alpha offers limited evidence of the reliability of a research instrument, and that indeed a very high value may actually be undesirable when developing a test of scientific knowledge or understanding. Guidance is offered to authors reporting, and readers evaluating, studies that present Cronbach's alpha statistic as evidence of instrument quality.

Connected Vehicle Pilot Deployment Program phase I : comprehensive Pilot Deployment Plan : Tampa Hillsborough Expressway Authority (THEA) : final report.

DOT National Transportation Integrated Search

2016-07-01

The Tampa Hillsborough Expressway Authority (THEA) Connected Vehicle (CV) Pilot Deployment Program is part of a national effort to advance CV technologies by deploying, demonstrating, testing and offering lessons learned for future deployers. The THE...

36 CFR 261.10 - Occupancy and use.

Code of Federal Regulations, 2010 CFR

2010-07-01

... authorization is required. (c) Selling or offering for sale any merchandise or conducting any kind of work... convenience of any person. (g) Commercial distribution of printed material without a special use authorization... Forest System lands; misrepresenting the purposes or affiliations of those selling or distributing the...

[Effects of sterilization and disinfection on mechanical properties of Sentalloy springs].

PubMed

Maddalone, M; Amalto, L; Cocconi, R; Ciafone, E

1991-01-01

The Authors evaluated mechanic characteristics of open and close titanium coils after two cycles of simulated usage. Coils undergone to thermic autoclaving didn't show any substantial variation in the forces offered compared to those only disinfected, authorizing reusage with igienic guarantees.

Teaching Strategies with Pedometers for All Children

ERIC Educational Resources Information Center

Foley, John Thomas; Lieberman, Lauren J.; Wood, Barbara

2008-01-01

The authors suggest incorporating pedometers into the physical education curricula for schoolchildren, especially children with visual impairment, as a way to combat childhood obesity. The authors offer activity ideas to incorporate pedometers into physical education classes and to encourage children with visual impairment to participate more…

Chittenden County Transportation Authority, Vermont multimodal passenger information, transit signal priority and ITS system planning local evaluation report

DOT National Transportation Integrated Search

2006-06-01

The Chittenden County Transportation Authority (CCTA) was founded in 1973 by the Vermont Legislature and provides transit services in northwestern Vermont. CCTA is a full service public transportation provider, offering services including fixed route...

Social Justice Language Teacher Education

ERIC Educational Resources Information Center

Hawkins, Margaret R.

2011-01-01

Social justice language teacher education conceptualizes language teacher education as responding to social and societal inequities that result in unequal access to educational and life opportunities. In this volume authors articulate a global view of Social Justice Language Teacher Education, with authors from 7 countries offering a theorized…

Less power or powerless? Egocentric empathy gaps and the irony of having little versus no power in social decision making.

PubMed

Handgraaf, Michel J J; Van Dijk, Eric; Vermunt, Riël C; Wilke, Henk A M; De Dreu, Carsten K W

2008-11-01

The authors investigate the effect of power differences and associated expectations in social decision making. Using a modified ultimatum game, the authors show that allocators lower their offers to recipients when the power difference shifts in favor of the allocator. Remarkably, however, when recipients are completely powerless, offers increase. This effect is mediated by a change in framing of the situation: When the opponent is without power, feelings of social responsibility are evoked. On the recipient side, the authors show that recipients do not anticipate these higher outcomes resulting from powerlessness. They prefer more power over less, expecting higher outcomes when they are more powerful, especially when less power entails powerlessness. Results are discussed in relation to empathy gaps and social responsibility. (c) 2008 APA, all rights reserved.

Psychodynamic Therapists' Reservations About Cognitive-Behavioral Therapy

PubMed Central

PERSONS, JACQUELINE B.; GROSS, JAMES J.; ETKIN, MARK S.; MADAN, SIMONE K.

1996-01-01

This article offers suggestions for psychodynamic therapists who encounter obstacles while learning cognitive-behavioral therapy (CBT) or working in settings where CBT is used. The authors discuss three types of questions commonly raised by psychodynamic therapists about CBT. These concern 1) the therapeutic relationship, 2) the focus of therapeutic interventions, and 3) the depth of change. To help psychodynamic therapists overcome obstacles to learning CBT, the authors focus on similarities between psychodynamic and cognitive-behavioral models in these three areas. They also examine differences between the models, including differences dependent on value judgments, and offer suggestions for making productive use of differences between the models in the training process. PMID:22700289

Analysis of Latino Award Winning Children's Literature

ERIC Educational Resources Information Center

Gomm, Jeff; Heath, Melissa Allen; Mora, Pat

2017-01-01

In this article, we offer information about the specific challenges US Latino immigrant children face. We then determine which of these challenges are included in 72 award winning children's picture books, specifically created for and/or about Latino children. Our analysis offers information to assist school-based mental health professionals,…

Direct fluorescent-dye labeling of α-tubulin in mammalian cells for live cell and superresolution imaging.

PubMed

Schvartz, Tomer; Aloush, Noa; Goliand, Inna; Segal, Inbar; Nachmias, Dikla; Arbely, Eyal; Elia, Natalie

2017-10-15

Genetic code expansion and bioorthogonal labeling provide for the first time a way for direct, site-specific labeling of proteins with fluorescent-dyes in live cells. Although the small size and superb photophysical parameters of fluorescent-dyes offer unique advantages for high-resolution microscopy, this approach has yet to be embraced as a tool in live cell imaging. Here we evaluated the feasibility of this approach by applying it for α-tubulin labeling. After a series of calibrations, we site-specifically labeled α-tubulin with silicon rhodamine (SiR) in live mammalian cells in an efficient and robust manner. SiR-labeled tubulin successfully incorporated into endogenous microtubules at high density, enabling video recording of microtubule dynamics in interphase and mitotic cells. Applying this labeling approach to structured illumination microscopy resulted in an increase in resolution, highlighting the advantages in using a smaller, brighter tag. Therefore, using our optimized assay, genetic code expansion provides an attractive tool for labeling proteins with a minimal, bright tag in quantitative high-resolution imaging. © 2017 Schvartz et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Dual-process theory and consumer response to front-of-package nutrition label formats.

PubMed

Sanjari, S Setareh; Jahn, Steffen; Boztug, Yasemin

2017-11-01

Nutrition labeling literature yields fragmented results about the effect of front-of-package (FOP) nutrition label formats on healthy food choice. Specifically, it is unclear which type of nutrition label format is effective across different shopping situations. To address this gap, the present review investigates the available nutrition labeling literature through the prism of dual-process theory, which posits that decisions are made either quickly and automatically (system 1) or slowly and deliberately (system 2). A systematically performed review of nutrition labeling literature returned 59 papers that provide findings that can be explained according to dual-process theory. The findings of these studies suggest that the effectiveness of nutrition label formats is influenced by the consumer's dominant processing system, which is a function of specific contexts and personal variables (eg, motivation, nutrition knowledge, time pressure, and depletion). Examination of reported findings through a situational processing perspective reveals that consumers might prefer different FOP nutrition label formats in different situations and can exhibit varying responses to the same label format across situations. This review offers several suggestions for policy makers and researchers to help improve current FOP nutrition label formats. © The Author(s) 2017. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Medical tourism: evidence from an Italian descriptive survey on pediatric neurorehabilitation treatment abroad.

PubMed

Trabacca, A; Ricci, S; Russo, L; Gennaro, L; Losito, L; De Rinaldis, M; Paloscia, C

2013-12-01

In recent years we have witnessed a rapidly-growing tendency to seek neurorehabilitation abroad. This study aimed at better understanding this practice through a analysis of the authorizations for pediatric neurorehabilitation services issued by Italian Regions. Descriptive retrospective survey study. Outpatient. Italian children travelling abroad for neurorehabilitation. We analyzed the number of authorizations granted in the 2008-2011 period by local health agencies of Italian regions to children aged 0-18 years applying for neurorehabilitation services abroad. Information was obtained from the Ministry of Health database management systems. Our analysis showed an extreme variability across Italian regions. This is probably suggestive of an unbalanced offer of pediatric neurorehabilitation services across regions, different mechanisms used to control the phenomenon. Our study looked specifically at the practice of neurorehabilitation abroad in order to encourage further and larger studies, even at international level. A greater integration of health systems with common policies is to be achieved in order to control this phenomenon in a field as sensitive as pediatric neurorehabilitation. Our study, which is the only study so far focusing on pediatric neurorehabilitation, looked specifically at the practice of health tourism in order to encourage further and larger studies, even at international level. Health tourism is a critical issue for all Western welfare systems which are under a pressure to cut health-related expenses.

Fly ash carbon burn-out at TVA`s Colbert and Shawnee Stations: Site specific application study. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cochran, J.W.; Kirkconnell, S.F.

1996-04-01

Many power plants, particularly after conversion to low-NOx burners, produce fly ash that is too high in carbon content to be successfully marketed as a concrete admixture. Fly ash beneficiation using Carbon Burn-Out (CBO) technology offers the opportunity to market fly ash that was previously landfilled. This site application study of beneficiating pulverized coal boiler fly ash at Tennessee Valley Authority`s Colbert and Shawnee Stations indicates this process is a cost effective solution for decreasing solid waste disposal, increasing landfill life, improving boiler heat rate, and generating a positive revenue stream. Results indicate that the Colbert Station has the flymore » ash market, site integration potential, and positive economics to support construction and operation of a CBO plant with an annual production rate of approximately 150,000 tons. As the market for fly ash increases, this capacity may be expanded to handle the majority of fly ash generated at Colbert. Results of the Shawnee Station analysis indicate that site integration constraints combined with the lack of near term local area fly ash market growth do not support construction and operation of a CBO plant. CBO commercial process design work in developing a generic commercial design resulted in a major improvement to the heat recovery portion of the process. This development resulted in the elimination of five major equipment items, with a corresponding reduction in plant complexity and costs. The design change is now considered part of the commercial offering.« less

scEpath: Energy landscape-based inference of transition probabilities and cellular trajectories from single-cell transcriptomic data.

PubMed

Jin, Suoqin; MacLean, Adam L; Peng, Tao; Nie, Qing

2018-02-05

Single-cell RNA-sequencing (scRNA-seq) offers unprecedented resolution for studying cellular decision-making processes. Robust inference of cell state transition paths and probabilities is an important yet challenging step in the analysis of these data. Here we present scEpath, an algorithm that calculates energy landscapes and probabilistic directed graphs in order to reconstruct developmental trajectories. We quantify the energy landscape using "single-cell energy" and distance-based measures, and find that the combination of these enables robust inference of the transition probabilities and lineage relationships between cell states. We also identify marker genes and gene expression patterns associated with cell state transitions. Our approach produces pseudotemporal orderings that are - in combination - more robust and accurate than current methods, and offers higher resolution dynamics of the cell state transitions, leading to new insight into key transition events during differentiation and development. Moreover, scEpath is robust to variation in the size of the input gene set, and is broadly unsupervised, requiring few parameters to be set by the user. Applications of scEpath led to the identification of a cell-cell communication network implicated in early human embryo development, and novel transcription factors important for myoblast differentiation. scEpath allows us to identify common and specific temporal dynamics and transcriptional factor programs along branched lineages, as well as the transition probabilities that control cell fates. A MATLAB package of scEpath is available at https://github.com/sqjin/scEpath. qnie@uci.edu. Supplementary data are available at Bioinformatics online. © The Author(s) 2018. Published by Oxford University Press.

Mouse IDGenes: a reference database for genetic interactions in the developing mouse brain.

PubMed

Matthes, Michaela; Preusse, Martin; Zhang, Jingzhong; Schechter, Julia; Mayer, Daniela; Lentes, Bernd; Theis, Fabian; Prakash, Nilima; Wurst, Wolfgang; Trümbach, Dietrich

2014-01-01

The study of developmental processes in the mouse and other vertebrates includes the understanding of patterning along the anterior-posterior, dorsal-ventral and medial- lateral axis. Specifically, neural development is also of great clinical relevance because several human neuropsychiatric disorders such as schizophrenia, autism disorders or drug addiction and also brain malformations are thought to have neurodevelopmental origins, i.e. pathogenesis initiates during childhood and adolescence. Impacts during early neurodevelopment might also predispose to late-onset neurodegenerative disorders, such as Parkinson's disease. The neural tube develops from its precursor tissue, the neural plate, in a patterning process that is determined by compartmentalization into morphogenetic units, the action of local signaling centers and a well-defined and locally restricted expression of genes and their interactions. While public databases provide gene expression data with spatio-temporal resolution, they usually neglect the genetic interactions that govern neural development. Here, we introduce Mouse IDGenes, a reference database for genetic interactions in the developing mouse brain. The database is highly curated and offers detailed information about gene expressions and the genetic interactions at the developing mid-/hindbrain boundary. To showcase the predictive power of interaction data, we infer new Wnt/β-catenin target genes by machine learning and validate one of them experimentally. The database is updated regularly. Moreover, it can easily be extended by the research community. Mouse IDGenes will contribute as an important resource to the research on mouse brain development, not exclusively by offering data retrieval, but also by allowing data input. http://mouseidgenes.helmholtz-muenchen.de. © The Author(s) 2014. Published by Oxford University Press.

Managing global accounts.

PubMed

Yip, George S; Bink, Audrey J M

2007-09-01

Global account management--which treats a multinational customer's operations as one integrated account, with coherent terms for pricing, product specifications, and service--has proliferated over the past decade. Yet according to the authors' research, only about a third of the suppliers that have offered GAM are pleased with the results. The unhappy majority may be suffering from confusion about when, how, and to whom to provide it. Yip, the director of research and innovation at Capgemini, and Bink, the head of marketing communications at Uxbridge College, have found that GAM can improve customer satisfaction by 20% or more and can raise both profits and revenues by at least 15% within just a few years of its introduction. They provide guidelines to help companies achieve similar results. The first steps are determining whether your products or services are appropriate for GAM, whether your customers want such a program, whether those customers are crucial to your strategy, and how GAM might affect your competitive advantage. If moving forward makes sense, the authors' exhibit, "A Scorecard for Selecting Global Accounts," can help you target the right customers. The final step is deciding which of three basic forms to offer: coordination GAM (in which national operations remain relatively strong), control GAM (in which the global operation and the national operations are fairly balanced), and separate GAM (in which a new business unit has total responsibility for global accounts). Given the difficulty and expense of providing multiple varieties, the vast majority of companies should initially customize just one---and they should be careful not to start with a choice that is too ambitious for either themselves or their customers to handle.

It's Not the Book, It's Not the Author, It's the Award: The Lambda Literary Award and the Case for Strategic Essentialism

ERIC Educational Resources Information Center

Crisp, Thomas

2011-01-01

On September 16, 2009, the Lambda Literary Foundation (LLF) released a statement revising their eligibility guidelines for the Lambda Literary Award, the most prestigious citation offered for LGBT books and authors. This criteria, which demands that an author must self-identify as a member of the LGBT family of writers, has been met with…

Holding Charter Authorizers Accountable: Why It Is Important and How It Might Be Done. NCSRP White Paper Series, Number 1

ERIC Educational Resources Information Center

Lake, Robin J.

2006-01-01

This paper takes on the question of whether and how school authorizers should be held accountable for their own performance. The author presents reasons why scrutiny and accountability are needed not only for schools but also for chartering agencies, identifies what types of accountability are present now, and offers ideas for ways accountability…

41 CFR 102-39.55 - When should I offer property I am exchanging or selling under the exchange/sale authority to...

Code of Federal Regulations, 2010 CFR

2010-07-01

... specified at § 102-38.125 of this title. The sales proceeds must be applied in whole or part payment for... property I am exchanging or selling under the exchange/sale authority to other Federal agencies or State... 39-REPLACEMENT OF PERSONAL PROPERTY PURSUANT TO THE EXCHANGE/SALE AUTHORITY Exchange/Sale...

41 CFR 102-39.55 - When should I offer property I am exchanging or selling under the exchange/sale authority to...

Code of Federal Regulations, 2013 CFR

2013-07-01

... specified at § 102-38.125 of this title. The sales proceeds must be applied in whole or part payment for... property I am exchanging or selling under the exchange/sale authority to other Federal agencies or State... 39-REPLACEMENT OF PERSONAL PROPERTY PURSUANT TO THE EXCHANGE/SALE AUTHORITY Exchange/Sale...

41 CFR 102-39.55 - When should I offer property I am exchanging or selling under the exchange/sale authority to...

Code of Federal Regulations, 2014 CFR

2014-01-01

... specified at § 102-38.125 of this title. The sales proceeds must be applied in whole or part payment for... property I am exchanging or selling under the exchange/sale authority to other Federal agencies or State... 39-REPLACEMENT OF PERSONAL PROPERTY PURSUANT TO THE EXCHANGE/SALE AUTHORITY Exchange/Sale...

41 CFR 102-39.55 - When should I offer property I am exchanging or selling under the exchange/sale authority to...

Code of Federal Regulations, 2011 CFR

2011-01-01

... specified at § 102-38.125 of this title. The sales proceeds must be applied in whole or part payment for... property I am exchanging or selling under the exchange/sale authority to other Federal agencies or State... 39-REPLACEMENT OF PERSONAL PROPERTY PURSUANT TO THE EXCHANGE/SALE AUTHORITY Exchange/Sale...

41 CFR 102-39.55 - When should I offer property I am exchanging or selling under the exchange/sale authority to...

Code of Federal Regulations, 2012 CFR

2012-01-01

... specified at § 102-38.125 of this title. The sales proceeds must be applied in whole or part payment for... property I am exchanging or selling under the exchange/sale authority to other Federal agencies or State... 39-REPLACEMENT OF PERSONAL PROPERTY PURSUANT TO THE EXCHANGE/SALE AUTHORITY Exchange/Sale...

On the Pursuit of Sound Science for the Betterment of the American Indian Community: Reply to Beals et al. (2009)

ERIC Educational Resources Information Center

Spillane, Nichea S.; Smith, Gregory T.

2009-01-01

The authors of this reply argue that ongoing criticism of existing theories, the development of alternative theories, and empirical theory tests offer the best chance for advancing American Indian research. The authors therefore note their appreciation for the comments of J. Beals et al. The authors nevertheless disagree with many of the specific…

The Anatomy of Coaching: Coaching through Storytelling

ERIC Educational Resources Information Center

Blackstone, Phyllis A.

2007-01-01

In this article, the author posits that storytelling can be used as a method for developing positive interpersonal relationships between coaches and classroom teachers. The author argues that developing interpersonal relationships is a necessary but challenging aspect of successful coaching, and that storytelling offers a mechanism for greater…

Developing "Assessment Capable" Learners

ERIC Educational Resources Information Center

Frey, Nancy; Fisher, Douglas; Hattie, John

2018-01-01

For students, the authors argue, the ability to assess their own learning--that is, to actively understand their own progress and trajectory--can have a significant impact on achievement levels. The authors discuss factors associated with "assessment-capable learners" and offer examples of how to foster such characteristics in classrooms.

In Search of Activist Pedagogies in SMTE

ERIC Educational Resources Information Center

Alsop, Steve; Bencze, Larry

2012-01-01

David Burns and Stephen Norris's (2012) article entitled "Activist Environmental Education and Moral Philosophy" offers a thought-provoking response to the CJSMTE special edition. The authors would like to thank these authors for their supportive and philosophically adroit arguments. Burns and Norris provide an opportunity to continue…

47 CFR 63.09 - Definitions applicable to international Section 214 authorizations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... telecommunications services offered to the public in that country within the meaning of the International... 47 Telecommunication 3 2010-10-01 2010-10-01 false Definitions applicable to international Section... Extensions and Supplements § 63.09 Definitions applicable to international Section 214 authorizations. The...

10 CFR 810.9 - Restrictions on general and specific authorization.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Restrictions on general and specific authorization. 810.9 Section 810.9 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.9 Restrictions on general and specific authorization. A general or specific authorization granted by the...

10 CFR 810.9 - Restrictions on general and specific authorization.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 10 Energy 4 2012-01-01 2012-01-01 false Restrictions on general and specific authorization. 810.9 Section 810.9 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.9 Restrictions on general and specific authorization. A general or specific authorization granted by the...

10 CFR 810.9 - Restrictions on general and specific authorization.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 4 2011-01-01 2011-01-01 false Restrictions on general and specific authorization. 810.9 Section 810.9 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.9 Restrictions on general and specific authorization. A general or specific authorization granted by the...

10 CFR 810.9 - Restrictions on general and specific authorization.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Restrictions on general and specific authorization. 810.9 Section 810.9 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.9 Restrictions on general and specific authorization. A general or specific authorization granted by the...

10 CFR 810.9 - Restrictions on general and specific authorization.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Restrictions on general and specific authorization. 810.9 Section 810.9 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.9 Restrictions on general and specific authorization. A general or specific authorization granted by the...

Education in nuclear decommissioning in the north of Scotland

DOE Office of Scientific and Technical Information (OSTI.GOV)

Catlow, F.; Reeves, G.M.

2007-07-01

This paper describes the work covered and experience gained in the first two years of operation of DERC, a Centre for Decommissioning and Environmental Remediation in the Highlands of Scotland. The Centre is a unique development which was set up to teach nuclear decommissioning as a separate discipline, address the problem of a declining skills base in the field of nuclear technologies and to take advantage of the unique and exceptional innovative, technical and research opportunities offered through the decommissioning of Britain's fast reactor site at Dounreay. The Centre is an offshoot from North Highland College which is a membermore » of UHI, the University in embryo of the Highlands and Islands. The Centre currently supports ten PhD students completing various diverse projects mainly in the field of nuclear environmental remediation. In addition there area number of full and part time MSc students who participate in NTEC (Nuclear Technology Education Consortium) a consortium of British Universities set up specifically to engender interest and skills in nuclear technology at postgraduate level. At undergraduate level, courses are offered in Nuclear Decommissioning and related subjects as part of Electrical and Mechanical degree courses. In addition to our relationship with the United Kingdom Atomic Energy Authority (UKAEA) the Dounreay site licensee, we have links with Rolls-Royce and the Ministry of Defence who also share the Dounreay site and with other stakeholders such as, the UK regulator (HSE/NII), the Scottish Environmental Protection Agency (SEPA), local and international contractors and we liaise with the newly formed Nuclear Decommissioning Authority (NDA), who provide some sponsorship and support. We possess our own equipment and laboratories for taking and analysing soil samples and for conducting environmental surveys. Recently we commissioned an aerial survey of contamination in the locality from natural sources, other background levels such as Chernobyl fall out and any local activity from Dounreay. (authors)« less

Serving Boys through Readers' Advisory

ERIC Educational Resources Information Center

Sullivan, Michael

2010-01-01

Based on more than twenty years' experience working to get boys interested in reading, the author now offers his first readers' advisory volume. With an emphasis on nonfiction and the boy-friendly categories of genre fiction, the work offers a wealth of material including: (1) Suggestions for how to booktalk one-on-one as well as in large groups;…

Alternative Fuels Data Center: Utility Initiatives Foster Plug-In Electric

Science.gov Websites

free charger or a rebate toward qualified equipment purchases. Residential customers are sometimes Authority and others offer PEV purchase rebates. Utility programs offering free or reduced-cost EVSE are , also known as Pepco, to pilot discounted time-of-use rates and free EVSE. This has enabled utilities to

The Quality of Pedagogical Exercises in U.S. History Textbooks

ERIC Educational Resources Information Center

Lavere, David Bruce

2008-01-01

The author analyzes pedagogical exercises related to Native Americans in thirteen U.S. history textbooks currently used in grades three, four, five, eight, and eleven. The purpose of the research was to determine the extent to which U.S. history textbooks offer, or fail to offer, opportunities for students to engage in and develop higher-order…

Enhancing a Core Journal Collection for Digital Libraries

ERIC Educational Resources Information Center

Kovacevic, Ana; Devedzic, Vladan; Pocajt, Viktor

2010-01-01

Purpose: This paper aims to address the problem of enhancing the selection of titles offered by a digital library, by analysing the differences in these titles when they are cited by local authors in their publications and when they are listed in the digital library offer. Design/methodology/approach: Text mining techniques were used to identify…

13 CFR 127.503 - When is a contracting officer authorized to restrict competition under this part?

Code of Federal Regulations, 2013 CFR

2013-01-01

... be made at fair market prices. This requirement does not preclude a contracting officer from making... reasonable expectation based on market research that: (1) Two or more EDWOSBs will submit offers for the... reasonable expectation based on market research that: (1) Two or more WOSBs will submit offers (this includes...

Portals of Entry: University Colleges and Undergraduate Divisions. The Freshman Year Experience. Monograph Series Number 12.

ERIC Educational Resources Information Center

Strommer, Diane W., Ed.

This monograph offers seven case studies and supporting papers on university colleges and undergraduate divisions and their role in shaping the freshman college experience. An introductory section offers a preface, information on the authors and a first chapter "University Colleges Today" by Diane W. Strommer which examines the…

Geriatric-Focused Educational Offerings in the Department of Veterans Affairs from 1999 to 2009

ERIC Educational Resources Information Center

Thielke, Stephen; Tumosa, Nina; Lindenfeld, Rivkah; Shay, Kenneth

2011-01-01

The scope of geriatrics-related educational offerings in large health care systems, in either the target audiences or topics covered, has not previously been analyzed or reported in the professional literature. The authors reviewed the geriatrics-related educational sessions that were provided between 1999 and 2009 by the Geriatrics Research,…

Tax Expert Offers Ideas for Monitoring Big Spending on College Sports

ERIC Educational Resources Information Center

Sander, Libby

2009-01-01

The federal government could take a cue from its regulation of charitable organizations in monitoring the freewheeling fiscal habits of big-time college athletics, a leading tax lawyer says. The author reports on the ideas offered by John D. Colombo, a professor at the University of Illinois College of Law, for monitoring big spending on college…

"DI Days:" Differentiating Instruction through Student Choice. Classroom Tips

ERIC Educational Resources Information Center

Hammond, Donald J.

2011-01-01

To better meet the needs of the author's high school students, who have a variety of abilities, interests and engagement levels, he often differentiates instruction through the use of "DI Days." On these days, students use a choice board to select from a wide range of activities offered in learning centers. Each center offers content-focused…

Films with Few Words; A Multi-Sensory Approach to Writing, Reading, and Discussion.

ERIC Educational Resources Information Center

Sohn, David A.

1969-01-01

Concerned with the need to offer high school students organized practice in observing visual stimuli and writing about what they see, the author offers an annotated list of short films with little dialogue and narration that can conveniently be used in the classroom for teaching observation through the moving image. (LS)

The sociology of popular music, interdisciplinarity and aesthetic autonomy.

PubMed

Marshall, Lee

2011-03-01

This paper considers the impact of interdisciplinarity upon sociological research, focusing on one particular case: the academic study of popular music. 'Popular music studies' is an area of research characterized by interdisciplinarity and, in keeping with broader intellectual trends, this approach is assumed to offer significant advantages. As such, popular music studies is broadly typical of contemporary intellectual and governmental attitudes regarding the best way to research specific topics. Such interdisciplinarity, however, has potential costs and this paper highlights one of the most significant: an over-emphasis upon shared substantive interests and subsequent undervaluation of shared epistemological understandings. The end result is a form of 'ghettoization' within sociology itself, with residents of any particular ghetto displaying little awareness of developments in neighbouring ghettos. Reporting from one such ghetto, this paper considers some of the ways in which the sociology of popular music has been limited by its positioning within an interdisciplinary environment and suggests two strategies for developing a more fully-realized sociology of popular music. First, based on the assumption that a sociological understanding of popular music shares much in common with a sociological understanding of everything else, this paper calls for increased intradisciplinary research between sociologists of varying specialisms. The second strategy, however, involves a reconceptualization of the disciplinary limits of sociology, as it argues that a sociology of popular music needs to accept musical specificity as part of its remit. Such acceptance has thus far been limited not only by an interdisciplinary context but also by the long-standing sociological scepticism toward the analysis of aesthetic objects. As such, this paper offers an intervention into wider debates concerning the remit of sociological enquiry, and whether it is ever appropriate for sociological analyses of culture to consider 'internal' aesthetic structures. In relation to the specific case study, the paper argues that considering musical specificity is a necessary component of a sociology of popular music, and some possibilities for developing a 'materialist sociology of music' are outlined. © The Author 2011.

Influence of faith-based organisations on HIV prevention strategies in Africa: a systematic review.

PubMed

Ochillo, Marylyn A; van Teijlingen, Edwin; Hind, Martin

2017-09-01

The HIV/AIDS epidemic remains of global significance and there is a need to target sub-Saharan Africa since it is the hardest hit region worldwide. Religion and more specifically faith-based organisations can have an effect on socio-cultural factors that increase or decrease the risk of infection; and offer preventative interventions to the wider community. To understand the influence of faith-based organisations on HIV prevention in Africa. The main search engine of a British university 'mysearch' was used as this incorporates all relevant databases. Studies were also retrieved by searches within Google scholar, PubMed and reference lists of included papers were hand searched. The authors assessed the relevance of each article separately against the inclusion criteria. The data extraction form was piloted by the first author and cross-checked by the other authors. Seven studies met all inclusion criteria and were reviewed. Seven individual themes were identified. However, for the purposes of focus within this paper only two themes were focused on. Given the accessibility of faith-based organisations (FBOs) and the coverage of religion among the population, FBOs are potentially important players in HIV prevention. Therefore, more resources and support should be given to support their health promotion strategies.

Breast tumor segmentation in high resolution x-ray phase contrast analyzer based computed tomography.

PubMed

Brun, E; Grandl, S; Sztrókay-Gaul, A; Barbone, G; Mittone, A; Gasilov, S; Bravin, A; Coan, P

2014-11-01

Phase contrast computed tomography has emerged as an imaging method, which is able to outperform present day clinical mammography in breast tumor visualization while maintaining an equivalent average dose. To this day, no segmentation technique takes into account the specificity of the phase contrast signal. In this study, the authors propose a new mathematical framework for human-guided breast tumor segmentation. This method has been applied to high-resolution images of excised human organs, each of several gigabytes. The authors present a segmentation procedure based on the viscous watershed transform and demonstrate the efficacy of this method on analyzer based phase contrast images. The segmentation of tumors inside two full human breasts is then shown as an example of this procedure's possible applications. A correct and precise identification of the tumor boundaries was obtained and confirmed by manual contouring performed independently by four experienced radiologists. The authors demonstrate that applying the watershed viscous transform allows them to perform the segmentation of tumors in high-resolution x-ray analyzer based phase contrast breast computed tomography images. Combining the additional information provided by the segmentation procedure with the already high definition of morphological details and tissue boundaries offered by phase contrast imaging techniques, will represent a valuable multistep procedure to be used in future medical diagnostic applications.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brun, E., E-mail: emmanuel.brun@esrf.fr; Grandl, S.; Sztrókay-Gaul, A.

Purpose: Phase contrast computed tomography has emerged as an imaging method, which is able to outperform present day clinical mammography in breast tumor visualization while maintaining an equivalent average dose. To this day, no segmentation technique takes into account the specificity of the phase contrast signal. In this study, the authors propose a new mathematical framework for human-guided breast tumor segmentation. This method has been applied to high-resolution images of excised human organs, each of several gigabytes. Methods: The authors present a segmentation procedure based on the viscous watershed transform and demonstrate the efficacy of this method on analyzer basedmore » phase contrast images. The segmentation of tumors inside two full human breasts is then shown as an example of this procedure’s possible applications. Results: A correct and precise identification of the tumor boundaries was obtained and confirmed by manual contouring performed independently by four experienced radiologists. Conclusions: The authors demonstrate that applying the watershed viscous transform allows them to perform the segmentation of tumors in high-resolution x-ray analyzer based phase contrast breast computed tomography images. Combining the additional information provided by the segmentation procedure with the already high definition of morphological details and tissue boundaries offered by phase contrast imaging techniques, will represent a valuable multistep procedure to be used in future medical diagnostic applications.« less

New Author Choice for Open Access

NASA Astrophysics Data System (ADS)

2007-04-01

AGU journals now offer authors the opportunity to make their articles open for others to read for free. Authors choosing this option pay a fee based on article length and number of figures; these charges are designed to offset the potential loss of subscription income. This new option, called Author Choice, provides •Unlimited access to the article for all readers from the moment of publication. • Permission to deposit the PDF version in institutional repositories so long as the repository accepts AGU copyright permissions. • Continued copyright protection to prevent unauthorized uses of the author's work.

Organ donation as transition work: Policy discourse and clinical practice in The Netherlands.

PubMed

Paul, Katharina T; Avezaat, Cees J J; Ijzermans, Jan N; Friele, Roland D; Bal, Roland A

2014-07-01

An increasing number of patients become eligible for organ transplants. In the Netherlands, at the level of policy discourse, growing waiting lists are often referred to as a persistent "shortage" of organs, producing a "public health crisis." In this way, organ donation is presented as an ethical, social, and medical necessity. Likewise, policy discourse offers a range of seemingly unambiguous solutions: improving logistical infrastructure at the level of hospitals, developing organizational and legal protocols, as well as public information campaigns. Instead of taking these problem and solution definitions as given, we critically examine the relationship between policy discourse and clinical practice. Based on a historical review, first, we trace the key moments of transformation where organ donation became naturalized in Dutch policy discourse, particularly in its altruistic connotation. Second, based on in-depth interviews with medical professionals, we show how those involved in organ donation continue to struggle with the controversial nature of their clinical practice. More specifically, we highlight their use of different forms of knowledge that underlie clinicians' "transition work": from losing a patient to "gaining" a donor. © The Author(s) 2013.

Teachable Moments Matter for: An analysis of the use of Pharmacy Curriculum Outcomes Assessment (PCOA) scores within one professional program.

PubMed

Peeters, Michael J; Garavalia, Linda S

Editors Note: The Teachable Moments Matter category of articles is designed to offer readers insight into a methodological issue identified within a companion article. Written in collaboration with one of these authors, these articles provide an opportunity to focus on a challenge experienced by the authors and, in the process, provide one or more perspectives as to how to successfully navigate this issue. Notably, this "issue" is not necessarily a problem (as this first paper in this series demonstrates). The Journal hopes this case-based approach will help highlight an issue nuance in context, something that might get "lost" in the entirety of a full-length article. This article discusses the importance of communicating a conceptual framework (i.e., theory) as a basis for scholarly articles. A specific example in the companion article is use of validity theory. In our community of researchers, we need to better communicate a conceptual framework as a basis to allow others to build on and grow our knowledge in pharmacy education. Copyright © 2017 Elsevier Inc. All rights reserved.

Introduction of Sap ERP System Into a Heterogeneous Academic Community

NASA Astrophysics Data System (ADS)

Mornar, Vedran; Fertalj, Krešimir; Kalpić, Damir

2010-06-01

Introduction of a complex ERP system like SAP into a heterogeneous academic environment like the University of Zagreb is far from being a trivial task. The University comprises more than 30 constituents, called faculties or academies, geographically dispersed, with long and specific traditions. Financing according to the lump sum principle, enforced in Croatia as a side effect of the in Europe obligatory and omnipresent Bologna process, requires a unified view on the educational institutions in order to provide a more just and appropriate financing scheme than the current one. After the experience with own development to support educational tasks and student administration, for standard financial and administration tasks SAP has been chosen as the most appropriate platform. The developer was selected after public bidding and the authors' institution was chosen for the pilot project. The authors were playing principal roles in the process of successful deployment and still expect to offer their expertise for implementation in the rest of the University. However, serious risks stemming from lack of motivation by some constituents are present.

Euthanasia and palliative sedation in Belgium.

PubMed

Cohen-Almagor, Raphael; Ely, E Wesley

2018-01-04

The aim of this article is to use data from Belgium to analyse distinctions between palliative sedation and euthanasia. There is a need to reduce confusion and improve communication related to patient management at the end of life specifically regarding the rapidly expanding area of patient care that incorporates a spectrum of nuanced yet overlapping terms such as palliative care, sedation, palliative sedation, continued sedation, continued sedation until death, terminal sedation, voluntary euthanasia and involuntary euthanasia. Some physicians and nurses mistakenly think that relieving suffering at the end of life by heavily sedating patients is a form of euthanasia, when indeed it is merely responding to the ordinary and proportionate needs of the patient. Concerns are raised about abuse in the form of deliberate involuntary euthanasia, obfuscation and disregard for the processes sustaining the management of refractory suffering at the end of life. Some suggestions designed to improve patient management and prevent potential abuse are offered. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Implementing climate change mitigation in health services: the importance of context.

PubMed

Desmond, Sharon

2016-10-01

Academic interest in strategies to reduce the impact of health services on climate change is quickening. Research has largely focused on local innovations with little consideration of the contextual and systemic elements that influence sustainable development across health systems. A realistic framework specifically to guide decision-making by health care providers is still needed. To address this deficit, the literature is explored in relation to health services and climate change mitigation strategies, and the contextual factors that influence efforts to mitigate climate effects in health service delivery environments are highlighted. A conceptual framework is proposed that offers a model for the pursuit of sustainable development practice in health services. A set of propositions is advanced to provide a systems approach to assist decision-making by decoding the challenges faced in implementing sustainable health services. This has important implications for health care providers, funders and legislators since the financial, policy and regulatory environment of health care, along with its leadership and models of care generally conflict with carbon literacy and climate change mitigation strategies. © The Author(s) 2016.

Do the 'brain dead' merely appear to be alive?

PubMed

Nair-Collins, Michael; Miller, Franklin G

2017-11-01

The established view regarding 'brain death' in medicine and medical ethics is that patients determined to be dead by neurological criteria are dead in terms of a biological conception of death, not a philosophical conception of personhood, a social construction or a legal fiction. Although such individuals show apparent signs of being alive, in reality they are (biologically) dead, though this reality is masked by the intervention of medical technology. In this article, we argue that an appeal to the distinction between appearance and reality fails in defending the view that the 'brain dead' are dead. Specifically, this view relies on an inaccurate and overly simplistic account of the role of medical technology in the physiology of a 'brain dead' patient. We conclude by offering an explanation of why the conventional view on 'brain death', though mistaken, continues to be endorsed in light of its connection to organ transplantation and the dead donor rule. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Especial Skills in Experienced Archers.

PubMed

Nabavinik, Mahdi; Abaszadeh, Ali; Mehranmanesh, Mehrab; Rosenbaum, David A

2017-09-05

Especial skills are skills that are distinctive by virtue of massive practice within the narrow contexts in which they are expressed. In the first demonstration of especial skills, Keetch, Schmidt, Lee, and Young (2005) showed that experienced basketball players are better at shooting baskets from the foul line, where they had massive amounts of practice, than would expected from their success at other locations closer to or farther from the basket. Similar results were obtained for baseball throwing. The authors asked whether especial skills hold in archery, a sport requiring less movement. If the emergence of especial skills depends on large-scale movement, one would expect archery to escape so-called especialism. But if the emergence of especial skills reflects a more general tendency for highly specific learning, experienced archers should show especial skills. The authors obtained evidence consistent with the latter prediction. The expert archers did much better at their most highly practiced distance than would be expected by looking at the overall function relating shooting score to distance. We offer a mathematical model to account for this result. The findings attest to the generality of the especial skills phenomenon.

Psychoanalytic application and psychoanalytic integrity.

PubMed

O'Neill, Sylvia

2005-02-01

In this article, the author offers an analysis of psychoanalytic application, defined as the breaking of new conceptual ground in some field of knowledge whereby the new idea is conceived, and later articulated, with the aid of reference to analogous phenomena in psychoanalysis. It requires apt analogy based on competent understanding of the applied field and of psychoanalysis. Only when the relevant differences between the applied and psychoanalytic fields are grasped can the extent of certain parallels emerge. The thinking by analogy that comprises psychoanalytic application may be intuitive and implicit, but should be susceptible of explicit theoretical elaboration that specifies, precisely, the point(s) of correspondence between psychoanalysis and the applied field in relation to a precise specification of their relevant differences. Applied psychotherapy at the interface of the internal and external worlds (historically rooted in casework) is employed as a model. By analogy with Donnet's concept of the analytic site, the author proposes the concept of the psychodynamic (case)work site, and elaborates it for that applied field in order to elucidate the proposed principles of psychoanalytic application.

Psychoanalysis as a lifeline: a clinical study of a transference perversion.

PubMed

Baker, R

1994-08-01

Case material from the analysis of a fetishistic cross-dresser is reported. The evolution of a transference perversion and treatment impasse, in the form of the recalcitrant symptom of anal flatulence, is described. The patient's contrasting needs to cling perversely and addictively to the analyst, on the one hand, and to provoke an acting out of the countertransference, on the other, are placed in the context of his dread of rejection and potentially suicidal reaction. The author argues in favour of offering psychoanalysis as a lifeline, but with the condition that the psychoanalytic setting and boundaries are maintained and that gratifications are denied. Limited but precise interpretive psychoanalytic work in the transference was maintained. The relatively good outcome is explained in terms of the provision of safety, survival of the analyst and avoidance of countertransference acting out, which, in the author's view, represents an implicit and mutative transference interpretation, the specific factor in bringing about psychic change. This enabled the patient to recognise and accept the analyst as a 'new' object and, as a consequence, to question and reject his idealisation of the anal universe that he inhabited.

NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice.

PubMed

Lin, Jonathan B; Kubota, Shunsuke; Ban, Norimitsu; Yoshida, Mitsukuni; Santeford, Andrea; Sene, Abdoulaye; Nakamura, Rei; Zapata, Nicole; Kubota, Miyuki; Tsubota, Kazuo; Yoshino, Jun; Imai, Shin-Ichiro; Apte, Rajendra S

2016-09-27

Photoreceptor death is the endpoint of many blinding diseases. Identifying unifying pathogenic mechanisms in these diseases may offer global approaches for facilitating photoreceptor survival. We found that rod or cone photoreceptor-specific deletion of nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme in the major NAD(+) biosynthetic pathway beginning with nicotinamide, caused retinal degeneration. In both cases, we could rescue vision with nicotinamide mononucleotide (NMN). Significantly, retinal NAD(+) deficiency was an early feature of multiple mouse models of retinal dysfunction, including light-induced degeneration, streptozotocin-induced diabetic retinopathy, and age-associated dysfunction. Mechanistically, NAD(+) deficiency caused metabolic dysfunction and consequent photoreceptor death. We further demonstrate that the NAD(+)-dependent mitochondrial deacylases SIRT3 and SIRT5 play important roles in retinal homeostasis and that NAD(+) deficiency causes SIRT3 dysfunction. These findings demonstrate that NAD(+) biosynthesis is essential for vision, provide a foundation for future work to further clarify the mechanisms involved, and identify a unifying therapeutic target for diverse blinding diseases. Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.

Climate, environmental and socio-economic change: weighing up the balance in vector-borne disease transmission.

PubMed

Parham, Paul E; Waldock, Joanna; Christophides, George K; Hemming, Deborah; Agusto, Folashade; Evans, Katherine J; Fefferman, Nina; Gaff, Holly; Gumel, Abba; LaDeau, Shannon; Lenhart, Suzanne; Mickens, Ronald E; Naumova, Elena N; Ostfeld, Richard S; Ready, Paul D; Thomas, Matthew B; Velasco-Hernandez, Jorge; Michael, Edwin

2015-04-05

Arguably one of the most important effects of climate change is the potential impact on human health. While this is likely to take many forms, the implications for future transmission of vector-borne diseases (VBDs), given their ongoing contribution to global disease burden, are both extremely important and highly uncertain. In part, this is owing not only to data limitations and methodological challenges when integrating climate-driven VBD models and climate change projections, but also, perhaps most crucially, to the multitude of epidemiological, ecological and socio-economic factors that drive VBD transmission, and this complexity has generated considerable debate over the past 10-15 years. In this review, we seek to elucidate current knowledge around this topic, identify key themes and uncertainties, evaluate ongoing challenges and open research questions and, crucially, offer some solutions for the field. Although many of these challenges are ubiquitous across multiple VBDs, more specific issues also arise in different vector-pathogen systems. © 2015 The Author(s) Published by the Royal Society. All rights reserved.

Logic of energy conservation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schipper, L.; Darmstadter, J.

1978-01-01

Energy conservation is seen as a complex mix of economic and moral considerations, which should be applied to specific strategies for changing waste handling, lifestyle, growth, etc., after meaningful payoffs have been researched and identified. The author recommends measuring energy conservation in terms of primary energy resources saved, and evaluating changes in consumption patterns on the basis of indirect as well as direct energy use. He feels consideration should be given to the intensity of energy use as well as to before-and-after comparisons. Human factors and wellbeing need to be included in shifts from energy-intensive to labor-intensive equipment. Curtailment ofmore » energy supplies as a conservation technique is seen as less effective than substitution, changes in habit and attitude, and changes in the types of goods and services demanded. While add-on investments have short-term value, new capital-equipment investments offer greater energy and economic savings in the long run. The author cautions against using strict rules to determine energy efficiency by relating energy to gross national product. Conservation is seen as an economic stimulus when compared to the costs of not conserving. 14 references. (DCK)« less

The operating surgeon is an independent predictor of chest tube drainage following cardiac surgery.

PubMed

Dixon, Barry; Reid, David; Collins, Marnie; Newcomb, Andrew E; Rosalion, Alexander; Yap, Cheng-Hon; Santamaria, John D; Campbell, Duncan J

2014-04-01

Bleeding into the chest is a major cause of blood transfusion and adverse outcomes following cardiac surgery. The authors investigated predictors of bleeding following cardiac surgery to identify potentially correctable factors. Data were retrieved from the medical records of patients undergoing cardiac surgery over the period of 2002 to 2008. Multivariate analysis was used to identify the independent predictors of chest tube drainage. Tertiary hospital. Two thousand five hundred seventy-five patients. Cardiac surgery. The individual operating surgeon was independently associated with the extent of chest tube drainage. Other independent factors included internal mammary artery grafting, cardiopulmonary bypass time, urgency of surgery, tricuspid valve surgery, redo surgery, left ventricular impairment, male gender, lower body mass index and higher preoperative hemoglobin levels. Both a history of diabetes and administration of aprotinin were associated with reduced levels of chest tube drainage. The individual operating surgeon was an independent predictor of the extent of chest tube drainage. Attention to surgeon-specific factors offers the possibility of reduced bleeding, fewer transfusions, and improved patient outcomes. © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Controversies regarding the new oral anticoagulants for stroke prevention in patients with atrial fibrillation.

PubMed

Mohanty, Bibhu D; Looser, Patrick M; Gokanapudy, Lakshmi R; Handa, Rishi; Mohanty, Sudipta; Choi, Sharon S; Goldman, Martin E; Fuster, Valentin; Halperin, Jonathan L

2014-06-01

Increasing use of the new oral anticoagulants (NOACs) - dabigatran, rivaroxaban, and apixaban - has prompted considerable discussion in the medical community even as warfarin remains the mainstay of therapy. This article raises 10 controversial issues regarding the use of NOACs for stroke prevention in patients with atrial fibrillation, and offers a review of the latest available evidence. We provide a brief overview of the mechanism and dosing of these drugs, as well as a summary of the key clinical trials that have brought them into the spotlight. Comparative considerations relative to warfarin such as NOAC safety, efficacy, bleeding risk, reversibility, drug-transitioning and use in patients well controlled on warfarin are addressed. Use in select populations such as the elderly, those with coronary disease, renal impairment, or on multiple anti-platelet drugs is also discussed. Finally, we consider such specific issues as comparative efficacy, off-label use, cost, rebound and management during events. Ultimately, the rise of the NOACs to mainstream use will depend on further data and clinical experience amongst the medical community. © The Author(s) 2014.

Professional e-mail communication among health care providers: proposing evidence-based guidelines.

PubMed

Malka, S Terez; Kessler, Chad S; Abraham, John; Emmet, Thomas W; Wilbur, Lee

2015-01-01

E-mail is now a primary method of correspondence in health care, and proficiency with professional e-mail use is a vital skill for physicians. Fundamentals of e-mail courtesy can be derived from lay literature, but there is a dearth of scientific literature that addresses the use of e-mail between physicians. E-mail communication between providers is generally more familiar and casual than other professional interactions, which can promote unprofessional behavior or misunderstanding. Not only e-mail content but also wording, format, and tone may influence clinical recommendations and perceptions of the e-mail sender. In addition, there are serious legal and ethical implications when unprofessional or unsecured e-mails related to patient-identifying information are exchanged or included within an electronic medical record. The authors believe that the appropriate use of e-mail is a vital skill for physicians, with serious legal and ethical ramifications and the potential to affect professional development and patient care. In this article, the authors analyze a comprehensive literature search, explore several facets of e-mail use between physicians, and offer specific recommendations for professional e-mail use.

A Case Review: Integrating Lewin’s Theory with Lean’s System Approach for Change

PubMed

Wojciechowski, Elizabeth; Pearsall, Tabitha; Murphy, Patricia; French, Eileen

2016-05-31

The complexity of healthcare calls for interprofessional collaboration to improve and sustain the best outcomes for safe and high quality patient care. Historically, rehabilitation nursing has been an area that relies heavily on interprofessional relationships. Professionals from various disciplines often subscribe to different change management theories for continuous quality improvement. Through a case review, authors describe how a large, Midwestern, rehabilitation hospital used the crosswalk methodology to facilitate interprofessional collaboration and develop an intervention model for implementing and sustaining bedside shift reporting. The authors provide project background and offer a brief overview of the two common frameworks used in this project, Lewin’s Three-Step Model for Change and the Lean Systems Approach. The description of the bedside shift report project methods demonstrates that multiple disciplines are able to utilize a common framework for leading and sustaining change to support outcomes of high quality and safe care, and capitalize on the opportunities of multiple views and discipline-specific approaches. The conclusion discusses outcomes, future initiatives, and implications for nursing practice.

Staff immunisation: policy and practice in child care.

PubMed

Spokes, Paula J; Ferson, Mark J; Ressler, Kelly-Anne

2011-08-01

The aims of this study were to determine the level of knowledge among child-care centre directors regarding the National Health and Medical Research Council (NHMRC) recommendations for the immunisation of child-care workers, the extent to which this knowledge was translated into practice and any organisational barriers to the development and implementation of staff immunisation policy. A cross-sectional survey, conducted in August 2006, in which a postal questionnaire was sent to a random sample of 784 NSW child-care centres. Centre directors were asked to complete the questionnaire on immunisation knowledge, policy and practice for the centre. A multivariate logistic-regression model was used to identify factors independently associated with centres with an immunisation policy for staff and centres that offered to pay all or part of the cost of vaccination of staff. Directors from 437 centres participated in the study for a response rate of 56%. Of these, 49% were aware of the NHMRC recommendations, and 57% had a staff immunisation policy in place. In the logistic regression model, centres with a written immunisation policy for staff were more likely to be aware of the NHMRC guidelines and offer long day care services. Centres that offered to pay all or part of the cost of immunisation for staff were more likely to be aware of the NHMRC guidelines, offer other child-care services and not operate for profit. Barriers to staff immunisation were related to the implementation of policy and included cost, time and access to information. The level of awareness of specific staff immunisation recommendations was relatively low. The transition of knowledge to policy was encouraging, although implementation of policies requires further commitment. © 2011 The Authors. Journal of Paediatrics and Child Health © 2011 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

Renewing the Covenant: Ten Years after the Kellogg Commission

ERIC Educational Resources Information Center

Spanier, Graham B.

2011-01-01

This article presents the author's remarks at the 11th Annual National Outreach Scholarship Conference. The author offers five strategies for advancing engagement at colleges and universities: (1) each institution needs to focus on activities that play to its strengths; (2) colleges and universities need to advance access for nontraditional…

Integrating the New Immigrant: A Model for Social Work Practice in Transitional States

ERIC Educational Resources Information Center

Golan, Naomi; Gruschka, Ruth

1971-01-01

The authors of this paper cast the process of immigration in the prevention intervention framework and offer a model for activity in six key areas: income management, health, housing, education, leisure time activities, and citizenship, by which the integration absorption crisis can be successfully resolved. (Author)

Reflections on Pedagogy: A Journey of Collaboration

ERIC Educational Resources Information Center

Woods, Christine

2011-01-01

One of the goals of autoethnography is to "offer lessons for further conversation". In this article, the author reflects on several lessons that were learnt along a journey in management education in the area of indigenous entrepreneurship. In particular, the author outlines her pedagogical practice as an academic engaged in teaching…

31 CFR 328.3 - Authorization for restrictive endorsements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 31 Money and Finance: Treasury 2 2014-07-01 2014-07-01 false Authorization for restrictive... date; (2) For exchange—during any period for their presentation pursuant to an exchange offering; (3) For redemption at par in payment of Federal estate taxes (only eligible securities)—at any time prior...

31 CFR 328.3 - Authorization for restrictive endorsements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance:Treasury 2 2011-07-01 2011-07-01 false Authorization for restrictive... date; (2) For exchange—during any period for their presentation pursuant to an exchange offering; (3) For redemption at par in payment of Federal estate taxes (only eligible securities)—at any time prior...

31 CFR 328.3 - Authorization for restrictive endorsements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance:Treasury 2 2013-07-01 2013-07-01 false Authorization for restrictive... date; (2) For exchange—during any period for their presentation pursuant to an exchange offering; (3) For redemption at par in payment of Federal estate taxes (only eligible securities)—at any time prior...

31 CFR 328.3 - Authorization for restrictive endorsements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance:Treasury 2 2012-07-01 2012-07-01 false Authorization for restrictive... date; (2) For exchange—during any period for their presentation pursuant to an exchange offering; (3) For redemption at par in payment of Federal estate taxes (only eligible securities)—at any time prior...

Philosophy in the Music Classroom: Poststructuralist Lessons from "The Lego Movie"

ERIC Educational Resources Information Center

Richerme, Lauren Kapalka

2015-01-01

This article introduces some of the practices in which various poststructuralist authors engage and suggests applications for music education. First, an explanation of how some poststructuralist authors embrace exclusions and how music educators might draw on such thinking and action is offered. Second, the article articulates various…

Presentation: For Challenging the Political Pilgrims

ERIC Educational Resources Information Center

London, Herbert

2003-01-01

This article presents the author's opening remarks during the tenth national convention of the National Association of Scholars (NAS) wherein he conferred Paul Hollander, a distinguished scholar of sociology and a prolific author, the Peter Shaw Award. More than any other scholar, Hollander offered documentation of a condition observed on campus.…

Leadership and the Fate of Organizations

ERIC Educational Resources Information Center

Kaiser, Robert B.; Hogan, Robert; Craig, S. Bartholomew

2008-01-01

This article concerns the real-world importance of leadership for the success or failure of organizations and social institutions. The authors propose conceptualizing leadership and evaluating leaders in terms of the performance of the team or organization for which they are responsible. The authors next offer a taxonomy of the dependent variables…

Identity, Intersectionality, and Mixed-Methods Approaches

ERIC Educational Resources Information Center

Harper, Casandra E.

2011-01-01

In this article, the author argues that current strategies to study and understand students' identities fall short of fully capturing their complexity. A multi-dimensional perspective and a mixed-methods approach can reveal nuance that is missed with current approaches. The author offers an illustration of how mixed-methods research can promote a…

22 CFR 96.12 - Authorized adoption service providers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Authorized adoption service providers. 96.12 Section 96.12 Foreign Relations DEPARTMENT OF STATE LEGAL AND RELATED SERVICES ACCREDITATION OF AGENCIES... (relating to transitional cases), an agency or person may not offer, provide, or facilitate the provision of...

Museums, Imagination and Education.

ERIC Educational Resources Information Center

United Nations Educational, Scientific, and Cultural Organization, Paris (France).

Twelve authors offer initiative and creative ideas for using museums to further world-wide education in a broad sense. Rather than viewing the museum as a preserver and storehouse of works and objectives, the authors see the museum as a place where direct involvement in process education occurs. International trends in museum education are focused…

What's Wrong with "Aesthetic Education"?

ERIC Educational Resources Information Center

Luca-Marshall, Judith B.

1980-01-01

The author considers definitions of "aesthetic," especially that offered by Woodrow Wilson in his essay on Adam Smith. Her major contention is that too much of aesthetic and other education is not very aesthetic, for it does not excite both senses and intellect nor develop the ability to generalize. (Author/SJL)

Teamwork through Team Building: Face-to-Face to Online

ERIC Educational Resources Information Center

Staggers, Julie; Garcia, Susan; Nagelhout, Ed

2008-01-01

This article describes the ways the authors incorporated team-building activities into our online business writing courses by interrogating the ways that kinesthetic learning translates into the electronic realm. The authors review foundational theories of team building, including Cog's Ladder and Tuckman's Stages, and offer sample exercises they…

Early Childhood Systems: Transforming Early Learning

ERIC Educational Resources Information Center

Kagan, Sharon Lynn, Ed.; Kauertz, Kristie, Ed.

2012-01-01

In this seminal volume, leading authorities strategize about how to create early childhood systems that transcend politics and economics to serve the needs of all young children. The authors offer different interpretations of the nature of early childhood systems, discuss the elements necessary to support their development, and examine how…

The Occult Today: Why?

ERIC Educational Resources Information Center

Kessler, Gary E.

1975-01-01

Author offered some reflections on the "why" of the contemporary interest in the occult. He attempted to convince the reader that, if he or she has been surprised by the recent rise of occultism, sober reflection will dispell some fears and, perhaps, even convince him or her that occultism is not merely superstition. (Author/RK)

Downsizing our Schools Corporate Style?

ERIC Educational Resources Information Center

Burton, Gary

2005-01-01

In this article, the author offers his views on downsizing the public schools in the US. To be efficient, American industries are redesigning themselves to stay competitive. Likewise, America's public schools are being prompted to do the same. The author contends that downsizing public schools may only cause adverse impact. Since education is…

The Value of Sustainability Education

ERIC Educational Resources Information Center

Bradfield, Steven L.

2009-01-01

This article offers the perspectives of a veteran in the field of sustainability. The author shares the steps in the development, evolution, and management of sustainability and sustainable practices at a leading flooring manufacturer. The author leverages over 20 years of experience in industry to discuss the necessary skills and mindsets to…

47 CFR 76.986 - “A la carte” offerings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... an extended 120 day period (if the franchise authority has requested an additional 90 days) pursuant... to the Commission within 14 days of the initial decision. Operators shall provide notice to franchise... provide notice to franchise authorities of their decision to appeal to the Commission within this period...

47 CFR 76.986 - “A la carte” offerings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... an extended 120 day period (if the franchise authority has requested an additional 90 days) pursuant... to the Commission within 14 days of the initial decision. Operators shall provide notice to franchise... provide notice to franchise authorities of their decision to appeal to the Commission within this period...

47 CFR 76.986 - “A la carte” offerings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... an extended 120 day period (if the franchise authority has requested an additional 90 days) pursuant... to the Commission within 14 days of the initial decision. Operators shall provide notice to franchise... provide notice to franchise authorities of their decision to appeal to the Commission within this period...

47 CFR 76.986 - “A la carte” offerings.

Code of Federal Regulations, 2014 CFR

2014-10-01

... an extended 120 day period (if the franchise authority has requested an additional 90 days) pursuant... to the Commission within 14 days of the initial decision. Operators shall provide notice to franchise... provide notice to franchise authorities of their decision to appeal to the Commission within this period...

47 CFR 76.986 - “A la carte” offerings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... an extended 120 day period (if the franchise authority has requested an additional 90 days) pursuant... to the Commission within 14 days of the initial decision. Operators shall provide notice to franchise... provide notice to franchise authorities of their decision to appeal to the Commission within this period...

76 FR 15212 - Redelegation of Authority to Compromise and Close Civil Claims

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-21

... Division directive delegates to a Principal Deputy Assistant Attorney General all of the Assistant Attorney... Review, and the Deputy Assistant Attorneys General, to compromise and close civil claims. In addition... Section 11 hereof, each of the Deputy Assistant Attorneys General is authorized to: (A) Accept offers in...

Survivor: The Library Edition

ERIC Educational Resources Information Center

Curzon, Susan Carol

2009-01-01

Six years ago, the author shared some strategies on managing a cutback ("Budget Shortfalls," "Library Journal" 5/15/03, p. 34-35). Now, people are in an even more severe economic downturn. In this article, the author offers some additional tips on how to cope with more budget shortfalls during this recession.

18 CFR 1314.3 - Authority of Reserve Banks.

Code of Federal Regulations, 2010 CFR

2010-04-01

... functions with respect to the issuance of Book-entry TVA Power Securities offered and sold by TVA to which this part 1314 applies, in accordance with the Securities Documentation, Reserve Bank Operating...-ENTRY PROCEDURES FOR TVA POWER SECURITIES ISSUED THROUGH THE FEDERAL RESERVE BANKS § 1314.3 Authority of...

Things that Keep Us up at Night

ERIC Educational Resources Information Center

Fitzpatrick, Kristen MacCartney; Walker, Willis C.

2006-01-01

In this article, the authors share their experiences as librarians, and offer their perspectives on issues critical to the new academic librarian. When the authors sat down to sort through ideas for this article, it became apparent that while their backgrounds, coursework, and experiences differed considerably, their passions and concerns are more…

School Renewal Through Staff Development.

ERIC Educational Resources Information Center

Schiffer, Judith

This book offers the premise that staff development plans are often based on politically naive assumptions about authority prerogatives. Three sources of authority: the public trust, the bureaucracy, and colleagues, are traced from colonial times through the progressive era. An analysis is given of the forces that have had an impact on educational…

Fluency Instruction. Research-Based Best Practices

ERIC Educational Resources Information Center

Rasinski, Timothy Ed.; Blachowicz, Camille Ed.; Lems, Kristin Ed.

2006-01-01

Because fluency instruction was identified, only recently, as a cornerstone literacy subject--it is still unfamiliar terrain for many teachers. This volume fills a crucial gap by offering a thorough, authoritative examination of what reading fluency is--and how it should be taught. Contributing authors, who include the field's leading authorities,…

Culturally Diverse Literature: Enriching Variety in an Era of Common Core State Standards

ERIC Educational Resources Information Center

Boyd, Fenice B.; Causey, Lauren L.; Galda, Lee

2015-01-01

The authors argue for the overwhelming importance of finding and including culturally diverse literature into the curricula teachers are authorized to teach. They discuss the implications of use and offer ideas on how to identify quality literature to include in classroom and school libraries.

A Breakfast with the Authors.

ERIC Educational Resources Information Center

Darigan, Dan

1997-01-01

Presents separate interviews with children's authors Bruce Coville and Paul Zelinsky. Suggests that Coville captures the interests and hearts of his readers by offering a different twist on the story and the world. Notes that Zelinsky, under the influence of Maurice Sendak, turned his art major into a career of making picture books. (RS)

The Role of Transnational Feminism in Psychology: Complementary Visions

ERIC Educational Resources Information Center

Grabe, Shelly; Else-Quest, Nicole M.

2012-01-01

Denmark and Segovich's (2012), Hyde's (2012), and Marecek's (2012) reflections on the authors' article (Else-Quest & Grabe, 2012) further bolster the need for feminist psychology to investigate gender disparities in power. The authors offer a rejoinder that draws together the commonalities in their various perspectives by putting the study of…

Architecture, Aesthetics, and Pluralism: Theories of Taste as a Determinant of Architectural Standards.

ERIC Educational Resources Information Center

Mann, Dennis Alan

1979-01-01

The author outlines and extends the description of "taste cultures" offered by Gans, indicating the aesthetic standards supported by different social classes in American society and suggesting how these standards operate in the form, content, composition, and contextual relationships of American architecture. (Author/SJL)

Group Work with Transgender Clients

ERIC Educational Resources Information Center

Dickey, Lore M.; Loewy, Michael I.

2010-01-01

Drawing on the existing literature, the authors' research and clinical experiences, and the first author's personal journey as a member and leader of the transgender community, this article offers a brief history of group work with transgender clients followed by suggestions for group work with transgender clients from a social justice…

Urinary Incontinence: Causes and Methods of Evaluation

ERIC Educational Resources Information Center

Griebling, Tomas L.

2008-01-01

This article presents the third of a multi-part series offering the most timely educational information, innovative approaches, products and technology solutions as well as coping and stigma-fighting approaches available on the subject of incontinence. Here, the author introduces the types and physiology of urinary incontinence. The author also…

How Wraparound Can Help Overcome Three Common Barriers to Successful Transition Services.

ERIC Educational Resources Information Center

Burchard, John D.

1998-01-01

Based on his experiences as the leader of Vermont's Department of Social and Rehabilitation Services and a transition researcher, the author describes why transitions from institutional settings to less restrictive ones are often unsuccessful. Also offers suggestions, including wraparound, for reversing this problem. (Author/MKA)

From Dissertation to Publication in JRME

ERIC Educational Resources Information Center

Thanheiser, Eva; Ellis, Amy; Herbel-Eisenmann, Beth

2012-01-01

Three "JRME" authors describe the process of publishing their research in "JRME". All 3 authors published parts of their dissertation in "JRME" and are sharing their stories to help (new) researchers in mathematics education better understand the process and to offer (experienced) researchers in mathematics education a tool that can be used to…

Experiencing Action Evaluation's Cyclic Process: Partnering Conflict, Reflection, and Action

ERIC Educational Resources Information Center

Burrows, Andrea C.; Harkness, Shelly Sheats

2016-01-01

In this article, the authors describe experiences in and offer suggestions from a course entitled "Educational Innovation for Excellence Through Action Research, Conflict Resolution, and Organizational Learning"--an action evaluation (AE). The class was taught using the principles of action research and AE. The authors explore the impact…

Timepiece: Extending and Enhancing Learning Time.

ERIC Educational Resources Information Center

Anderson, Lorin W., Ed.; Walberg, Herbert J., Ed.

This publication offers suggestions for making more productive use of time, a scarce and valued educational resource. The chapter authors, authorities on the use of educational time, write about how to extend and enhance learning time within and outside schools. In "Productive Use of Time," Herbert Walberg describes how learning time can be…

Open Source Software Development and Lotka's Law: Bibliometric Patterns in Programming.

ERIC Educational Resources Information Center

Newby, Gregory B.; Greenberg, Jane; Jones, Paul

2003-01-01

Applies Lotka's Law to metadata on open source software development. Authoring patterns found in software development productivity are found to be comparable to prior studies of Lotka's Law for scientific and scholarly publishing, and offer promise in predicting aggregate behavior of open source developers. (Author/LRW)

The integration of GC-MS and LC-MS to assay the metabolomics profiling in Panax ginseng and Panax quinquefolius reveals a tissue- and species-specific connectivity of primary metabolites and ginsenosides accumulation.

PubMed

Liu, Jia; Liu, Yang; Wang, Yu; Abozeid, Ann; Zu, Yuan-Gang; Tang, Zhong-Hua

2017-02-20

The traditional medicine Ginseng mainly including Panax ginseng and Panax quinquefolius is the most widely consumed herbal product in the world. Despite the extensive investigation of biosynthetic pathway of the active compounds ginsenosides, our current understanding of the metabolic interlink between ginsenosides synthesis and primary metabolism at the whole-plant level. In this study, the tissue-specific profiling of primary and the secondary metabolites in two different species of ginseng were investigated by gas chromatography- and liquid chromatography coupled to mass spectrometry. A complex continuous coordination of primary- and secondary-metabolic network was modulated by tissues and species factors during growth. The results showed that altogether 149 primary compounds and 10 ginsenosides were identified from main roots, lateral roots, stems, petioles and leaves in P. ginseng and P. quinquefolius. The partial least squares-discriminate analysis (PLS-DA) revealed obvious compounds distinction among tissue-specific districts relative to species. To survey the dedication of carbon and nitrogen metabolism in different tissues to the accumulation of ginsenosides, we inspected the tissue-specific metabolic changes. Our study testified that the ginsenosides content was dependent on main roots and lateral roots energy metabolism, whereas independent of leaves and petiole photosynthesis during ginsenosides accumulation. When tow species were compared, the results indicated that high rates of C assimilation to C accumulation are closely associated with ginsenosides accumulation in P. ginseng main roots and P. quinquefolius lateral roots, respectively. Taken together, our results suggest that tissue-specific metabolites profiling dynamically changed in process of ginsenosides biosynthesis, which may offer a new train of thoughts to the mechanisms of the ginsenosides biosynthesis at the metabolite level. Copyright © 2016 The Author(s). Published by Elsevier B.V. All rights reserved.

Professional competencies in health promotion and public health: what is common and what is specific? Review of the European debate and perspectives for professional development.

PubMed

Mereu, Alessandra; Sotgiu, Alessandra; Buja, Alessandra; Casuccio, Alessandra; Cecconi, Rosaria; Fabiani, Leila; Guberti, Emilia; Lorini, Chiara; Minelli, Liliana; Pocetta, Giancarlo; Contu, Paolo

2015-01-01

According to the Nairobi Call to Action, the growth of practitioners' skills can be favoured by setting accreditation standards and by reorienting professional competencies of current and future health workers. This will make it possible to develop a critical mass of competent practitioners, foster training, and increase visibility of the professional field. Through a review of the literature, the authors offer an overview of competency-based strategies for professional development in health promotion. The main research questions discussed were as follows: Is there a shared definition of public health?; Is there a shared definition of health promotion?; Who are the main stakeholders for public health and health promotion in Europe?; What is the meaning of professional competencies in education and practice for public health and health promotion?; Is there a shared system of professional core competencies in public health and health promotion?;What is common and what is specific between the two systems of professional competencies?; Is it useful and feasible to create specific strategies of professional development for public health and health promotion? A transformative use of competencies makes it possible to inform students, professionals, employers, and political decision-makers about what is expected from a specific profession and its values.

Learning to Rank Figures within a Biomedical Article

PubMed Central

Liu, Feifan; Yu, Hong

2014-01-01

Hundreds of millions of figures are available in biomedical literature, representing important biomedical experimental evidence. This ever-increasing sheer volume has made it difficult for scientists to effectively and accurately access figures of their interest, the process of which is crucial for validating research facts and for formulating or testing novel research hypotheses. Current figure search applications can't fully meet this challenge as the “bag of figures” assumption doesn't take into account the relationship among figures. In our previous study, hundreds of biomedical researchers have annotated articles in which they serve as corresponding authors. They ranked each figure in their paper based on a figure's importance at their discretion, referred to as “figure ranking”. Using this collection of annotated data, we investigated computational approaches to automatically rank figures. We exploited and extended the state-of-the-art listwise learning-to-rank algorithms and developed a new supervised-learning model BioFigRank. The cross-validation results show that BioFigRank yielded the best performance compared with other state-of-the-art computational models, and the greedy feature selection can further boost the ranking performance significantly. Furthermore, we carry out the evaluation by comparing BioFigRank with three-level competitive domain-specific human experts: (1) First Author, (2) Non-Author-In-Domain-Expert who is not the author nor co-author of an article but who works in the same field of the corresponding author of the article, and (3) Non-Author-Out-Domain-Expert who is not the author nor co-author of an article and who may or may not work in the same field of the corresponding author of an article. Our results show that BioFigRank outperforms Non-Author-Out-Domain-Expert and performs as well as Non-Author-In-Domain-Expert. Although BioFigRank underperforms First Author, since most biomedical researchers are either in- or out-domain-experts for an article, we conclude that BioFigRank represents an artificial intelligence system that offers expert-level intelligence to help biomedical researchers to navigate increasingly proliferated big data efficiently. PMID:24625719

Learning to rank figures within a biomedical article.

PubMed

Liu, Feifan; Yu, Hong

2014-01-01

Hundreds of millions of figures are available in biomedical literature, representing important biomedical experimental evidence. This ever-increasing sheer volume has made it difficult for scientists to effectively and accurately access figures of their interest, the process of which is crucial for validating research facts and for formulating or testing novel research hypotheses. Current figure search applications can't fully meet this challenge as the "bag of figures" assumption doesn't take into account the relationship among figures. In our previous study, hundreds of biomedical researchers have annotated articles in which they serve as corresponding authors. They ranked each figure in their paper based on a figure's importance at their discretion, referred to as "figure ranking". Using this collection of annotated data, we investigated computational approaches to automatically rank figures. We exploited and extended the state-of-the-art listwise learning-to-rank algorithms and developed a new supervised-learning model BioFigRank. The cross-validation results show that BioFigRank yielded the best performance compared with other state-of-the-art computational models, and the greedy feature selection can further boost the ranking performance significantly. Furthermore, we carry out the evaluation by comparing BioFigRank with three-level competitive domain-specific human experts: (1) First Author, (2) Non-Author-In-Domain-Expert who is not the author nor co-author of an article but who works in the same field of the corresponding author of the article, and (3) Non-Author-Out-Domain-Expert who is not the author nor co-author of an article and who may or may not work in the same field of the corresponding author of an article. Our results show that BioFigRank outperforms Non-Author-Out-Domain-Expert and performs as well as Non-Author-In-Domain-Expert. Although BioFigRank underperforms First Author, since most biomedical researchers are either in- or out-domain-experts for an article, we conclude that BioFigRank represents an artificial intelligence system that offers expert-level intelligence to help biomedical researchers to navigate increasingly proliferated big data efficiently.

Bioinformatics tools for the analysis of NMR metabolomics studies focused on the identification of clinically relevant biomarkers.

PubMed

Puchades-Carrasco, Leonor; Palomino-Schätzlein, Martina; Pérez-Rambla, Clara; Pineda-Lucena, Antonio

2016-05-01

Metabolomics, a systems biology approach focused on the global study of the metabolome, offers a tremendous potential in the analysis of clinical samples. Among other applications, metabolomics enables mapping of biochemical alterations involved in the pathogenesis of diseases, and offers the opportunity to noninvasively identify diagnostic, prognostic and predictive biomarkers that could translate into early therapeutic interventions. Particularly, metabolomics by Nuclear Magnetic Resonance (NMR) has the ability to simultaneously detect and structurally characterize an abundance of metabolic components, even when their identities are unknown. Analysis of the data generated using this experimental approach requires the application of statistical and bioinformatics tools for the correct interpretation of the results. This review focuses on the different steps involved in the metabolomics characterization of biofluids for clinical applications, ranging from the design of the study to the biological interpretation of the results. Particular emphasis is devoted to the specific procedures required for the processing and interpretation of NMR data with a focus on the identification of clinically relevant biomarkers. © The Author 2015. Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

Marketing of personalized cancer care on the web: an analysis of Internet websites.

PubMed

Gray, Stacy W; Cronin, Angel; Bair, Elizabeth; Lindeman, Neal; Viswanath, Vish; Janeway, Katherine A

2015-05-01

Internet marketing may accelerate the use of care based on genomic or tumor-derived data. However, online marketing may be detrimental if it endorses products of unproven benefit. We conducted an analysis of Internet websites to identify personalized cancer medicine (PCM) products and claims. A Delphi Panel categorized PCM as standard or nonstandard based on evidence of clinical utility. Fifty-five websites, sponsored by commercial entities, academic institutions, physicians, research institutes, and organizations, that marketed PCM included somatic (58%) and germline (20%) analysis, interpretive services (15%), and physicians/institutions offering personalized care (44%). Of 32 sites offering somatic analysis, 56% included specific test information (range 1-152 tests). All statistical tests were two-sided, and comparisons of website content were conducted using McNemar's test. More websites contained information about the benefits than limitations of PCM (85% vs 27%, P < .001). Websites specifying somatic analysis were statistically significantly more likely to market one or more nonstandard tests as compared with standard tests (88% vs 44%, P = .04). © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Particularism in health care: challenging the authority of the aggregate.

PubMed

Tanenbaum, Sandra J

2014-12-01

In health care, particularism asserts the primacy of the individual case. Moral particularists, such as Jonsen and Toulmin, reject deduction from universal moral principles and instead seek warrants for action from the multiple sources unique to a given patient. Another kind of health care particularism, here referred to as the knowledge of particulars, is offered as a corrective to evidence-based medicine (EBM), its influence on health care practice and policy, and specifically to EBM's reliance on the aggregate. This paper describes the knowledge of particulars and identifies strategies for its legitimation in health care policy and practice. First, the paper documents the ascendancy of the aggregate through EBM's definition of 'what works' in health care. Second, it delineates the limits of health care knowledge based on the analysis of aggregates, not only for the care of individual patients but for the formulation of policies about patient care. Third, the paper analyses prominent rejections of the particular in contemporary health policy discourse and relates them to larger political purposes. Finally, it depicts the knowledge of particulars as the basis for clinical prudence and offers three potential strategies for promoting particularism as essential to high-quality care. © 2014 John Wiley & Sons, Ltd.

Updates in the management of sinonasal mucosal melanoma.

PubMed

Crippen, Meghan M; Kılıç, Suat; Eloy, Jean A

2018-02-01

Sinonasal mucosal melanoma (SNMM) is an aggressive cancer with a poor prognosis. Although there is significant study surrounding the treatment of sinonasal malignancies and cutaneous melanomas, the rarity of this tumor has largely precluded robust outcomes analyses. The authors of this review seek to provide an overview of the recent literature related to the treatment of SNMM with added context from our institutional experience with this disease. In the surgical management of sinonasal malignancies and SNMM specifically, resection via endoscopic endonasal technique appears to offer comparable oncologic outcomes versus an open approach. The role of adjuvant therapy continues to be debated, but there is strong evidence for improved rates of local control with radiotherapy after complete resection. In the last few years, significant developments have been made in the study of systemic therapies for cutaneous melanoma. The identification of genetic mutations common to mucosal melanoma has allowed for early trials of targeted therapies, but study is ongoing. Although the study of SNMM is largely limited to small retrospective case series, treatment continues to evolve. Until effective systemic therapies can be identified, endoscopic resection with adjuvant radiotherapy may offer the best disease-free survival with acceptably low morbidity.

Factors Associated with Forensic Nurses Offering HIV nPEP status-post Sexual Assault

PubMed Central

Draughon, Jessica E.; Hauda, William E.; Price, Bonnie; Rotolo, Sue; Austin, Kim Wieczorek; Sheridan, Daniel J.

2014-01-01

Non-occupational post-exposure prophylaxis (nPEP) for Human Immunodeficiency Virus (HIV) is offered inconsistently to patients who have been sexually assaulted. This may be due to Forensic Nurse Examiner (FNE) programs utilizing diverse nPEP protocols and HIV risk assessment algorithms. This study examines factors associated with FNEs offering nPEP to patients following sexual assault at two FNE programs in urban settings. Offering nPEP is mostly driven by site-specific protocol. At Site 1 in addition to open anal or open genital wounds, the presence of injury to the head or face was associated with FNEs offering nPEP (AOR 64.15, 95%CI [2.12 – 1942.37]). At Site 2, patients assaulted by someone of other race/ethnicity (non-White, non-African American) were 86% less likely to be offered nPEP (AOR 0.14, 95%CI [.03-.72]) than patients assaulted by Whites. In addition to following site specific protocols, future research should further explore the mechanisms influencing clinician decision making. PMID:24733232

The world can look better: enhancing beauty experience with brain stimulation.

PubMed

Cattaneo, Zaira; Lega, Carlotta; Flexas, Albert; Nadal, Marcos; Munar, Enric; Cela-Conde, Camilo J

2014-11-01

Aesthetic appreciation is part of our everyday life: it is a subjective judgment we make when looking at a painting, a landscape, or--in fact--at another person. Neuroimaging and electrophysiological evidence suggests that the left dorsolateral prefrontal cortex (DLPFC) plays a critical role in aesthetic judgments. Here, we show that the experience of beauty can be artificially enhanced with brain stimulation. Specifically, we show that aesthetic appreciation of representational paintings and photographs can be increased by applying anodal (excitatory) transcranial direct current stimulation on the left DLPFC. Our results thus show that beauty is in the brain of the beholder, and offer a novel view on the neural networks underlying aesthetic appreciation. © The Author (2013). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

Library learning space--empirical research and perspective.

PubMed

Littleton, Dawn; Rethlefsen, Melissa

2008-01-01

Navigate the Net columns offer navigation to Web sites of value to medical librarians. For this issue, the authors recognize that librarians are frequently challenged to justify the need for the physical space occupied by a library in the context of the wide availability of electronic resources, ubiquitous student laptops, and competition for space needed by other institutional priorities. While this trend started years ago, it continues to raise a number of important practical and philosophical questions for libraries and the institutions they serve. What is the library for? What is library space best used for? How does the concept of "Library as Place" support informed decisions for librarians and space planners? In this issue, Web-based resources are surveyed that address these questions for libraries generally and health sciences libraries more specifically.

Novel therapies in advanced renal cell carcinoma: management of adverse events from sorafenib and sunitinib.

PubMed

Ivanyi, Philipp; Winkler, Thomas; Ganser, Arnold; Reuter, Christoph; Grünwald, Viktor

2008-03-01

Sorafenib and Sunitinib are the first tyrosine kinase inhibitors licensed for the treatment of advanced renal cell carcinoma. In contrast to conventional chemotherapy, targeted therapies have distinct and specific side effects. Selective review in Medline and the data base of the American Society of Clinical Oncology on the treatment and side effects of tyrosine kinase inhibitors in renal cell carcinoma, drawing on the authors' own experience. Tyrosine kinase inhibitors are characterized by a variety of uncommon side effects, such as lassitude, mucosal inflammation and skin changes. The detection and treatment of adverse events are critical for interdisciplinary cancer treatment in order to ensure patients' safety. This article offers an overview of the unwanted effects of drug therapy in the management of renal cell carcinoma.

Can solar access rights be protected by a revival of the doctrine of ancient lights

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weiss, R.B.

A review of the history of solar access rights from their origin in 13th Century England's Doctrine of Ancient Lights to the present state of the law in both England and the US discusses how solar access law developed and possible solutions to the current US problem through the use of federal and state legislation. To compensate for the inadequacy of the Doctrine of Ancient Lights, the author offers model legislation which recognizes the right to receive sunlight for the purpose of providing energy as a property right, and which prohibits acts which deprive an individual of that right. Themore » model bill specifically prohibits construction which interferes with sunlight necessary for solar energy equipment. 71 references.« less

Gregor Mendel's classic paper and the nature of science in genetics courses.

PubMed

Westerlund, Julie F; Fairbanks, Daniel J

2010-12-01

The discoveries of Gregor Mendel, as described by Mendel in his 1866 paper Versuche uber Pflanzen-Hybriden (Experiments on plant hybrids), can be used in undergraduate genetics and biology courses to engage students about specific nature of science characteristics and their relationship to four of his major contributions to genetics. The use of primary source literature as an instructional tool to enhance genetics students' understanding of the nature of science helps students more clearly understand how scientists work and how the science of genetics has evolved as a discipline. We offer a historical background of how the nature of science developed as a concept and show how Mendel's investigations of heredity can enrich biology and genetics courses by exemplifying the nature of science. © 2010 The Authors.

Sunken costs and desired plans: examining different types of investments in close relationships.

PubMed

Goodfriend, Wind; Agnew, Christopher R

2008-12-01

Although the concept of investments in romantic relationships has featured prominently in close relationships research, there have been no empirical analyses of different types of investments and their possible differential predictive power regarding relationship state or fate. With data from five independent samples, the authors offer and examine investments that differ in terms of their timing (past vs. planned) and materiality (tangible vs. intangible). Cross-sectional and longitudinal tests of hypotheses regarding these investment types provide evidence for the utility of considering specific types of investments in predicting a variety of important relationship factors, including commitment, stability, and the impact of breakup on relationship partners. Intangible investments and planned investments were found to be particularly robust predictors of key relational states and outcomes.

Nucleic Acid Templated Reactions for Chemical Biology.

PubMed

Di Pisa, Margherita; Seitz, Oliver

2017-06-21

Nucleic acid directed bioorthogonal reactions offer the fascinating opportunity to unveil and redirect a plethora of intracellular mechanisms. Nano- to picomolar amounts of specific RNA molecules serve as templates and catalyze the selective formation of molecules that 1) exert biological effects, or 2) provide measurable signals for RNA detection. Turnover of reactants on the template is a valuable asset when concentrations of RNA templates are low. The idea is to use RNA-templated reactions to fully control the biodistribution of drugs and to push the detection limits of DNA or RNA analytes to extraordinary sensitivities. Herein we review recent and instructive examples of conditional synthesis or release of compounds for in cellulo protein interference and intracellular nucleic acid imaging. © 2017 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

Effective Interpersonal Communication: A Practical Guide to Improve Your Life.

PubMed

Vertino, Kathleen A

2014-09-30

Use of effective interpersonal communication strategies by nurses in both personal and professional settings, may reduce stress, promote wellness, and therefore, improve overall quality of life. This article briefly explores the concept of interpersonal communication as it relates to Maslow's hierarchy of human needs; describes personal variables and the interaction of internal and external variables that can impact communication; and discusses possible causes and consequences of ineffective communication. Drawing on both the literature and experiences as a longtime provider of care in the mental health field, the author offers multiple practical strategies, with specific examples of possible responses for effective communication. Recommendations in this article are intended for nurses to consider as they seek healthy communication strategies that may be useful in both their personal and professional lives.

Critical Medical Anthropology in Midwifery Research: A Framework for Ethnographic Analysis.

PubMed

Newnham, Elizabeth C; Pincombe, Jan I; McKellar, Lois V

2016-01-01

In this article, we discuss the use of critical medical anthropology (CMA) as a theoretical framework for research in the maternity care setting. With reference to the doctoral research of the first author, we argue for the relevance of using CMA for research into the maternity care setting, particularly as it relates to midwifery. We then give an overview of an existing analytic model within CMA that we adapted for looking specifically at childbirth practices and which was then used in both analyzing the data and structuring the thesis. There is often no clear guide to the analysis or writing up of data in ethnographic research; we therefore offer this Critical analytic model of childbirth practices for other researchers conducting ethnographic research into childbirth or maternity care.

A Guide for Understanding Health Education and Promotion Programs.

PubMed

Kim, Richard W; Nahar, Vinayak K

2018-03-01

Planning, Implementing & Evaluating Health Promotion Programs: A Primer is a versatile and comprehensive resource on the theoretical and practical underpinnings of successful health promotion programs. The requirements for effective health promotion program development are presented with frequent use of practical planning examples, pedagogical devices, and expert rationale. Ideal for undergraduate and graduate students in health education, promotion, and planning courses, this 15-chapter textbook is organized in a manner that specifically addresses the responsibilities and competencies required of health education specialists as published in the Health Education Specialist Practice Analysis of 2015. The authors of this textbook are leaders in the field and provide readers with the skills necessary to carry out the full process of health promotion program execution, while also offering direct preparation for CHES and MCHES licensing exams.

Legal implications of premenstrual syndrome: a Canadian perspective.

PubMed Central

Meehan, E; MacRae, K

1986-01-01

A summary of the symptoms, prevalence and history of premenstrual syndrome (PMS) is presented. The legal implications of PMS, particularly its use as a defence in criminal prosecutions and as an implicit factor in specific offences, are discussed by means of an analysis of Canadian legal cases, with reference to those in England and the United States. The authors offer suggestions on how physicians can make use of PMS in a courtroom more reliable. They conclude that PMS is unlikely to become a substantive criminal defence until the medical community more fully recognizes its significance. Although the role of PMS as a mitigating factor in sentencing may be illogical, the courts now recognize the syndrome in a legally and practically important manner. Images p602-a PMID:3756691

[Amanitine determination as an example of peptide analysis in the biological samples with HPLC-MS technique].

PubMed

Janus, Tomasz; Jasionowicz, Ewa; Potocka-Banaś, Barbara; Borowiak, Krzysztof

Routine toxicological analysis is mostly focused on the identification of non-organic and organic, chemically different compounds, but generally with low mass, usually not greater than 500–600 Da. Peptide compounds with atomic mass higher than 900 Da are a specific analytical group. Several dozen of them are highly-toxic substances well known in toxicological practice, for example mushroom toxin and animal venoms. In the paper the authors present an example of alpha-amanitin to explain the analytical problems and different original solutions in identifying peptides in urine samples with the use of the universal LC MS/MS procedure. The analyzed material was urine samples collected from patients with potential mushroom intoxication, routinely diagnosed for amanitin determination. Ultra filtration with centrifuge filter tubes (limited mass cutoff 3 kDa) was used. Filtrate fluid was directly injected on the chromatographic column and analyzed with a mass detector (MS/MS). The separation of peptides as organic, amphoteric compounds from biological material with the use of the SPE technique is well known but requires dedicated, specific columns. The presented paper proved that with the fast and simple ultra filtration technique amanitin can be effectively isolated from urine, and the procedure offers satisfactory sensitivity of detection and eliminates the influence of the biological matrix on analytical results. Another problem which had to be solved was the non-characteristic fragmentation of peptides in the MS/MS procedure providing non-selective chromatograms. It is possible to use higher collision energies in the analytical procedure, which results in more characteristic mass spectres, although it offers lower sensitivity. The ultra filtration technique as a procedure of sample preparation is effective for the isolation of amanitin from the biological matrix. The monitoring of selected mass corresponding to transition with the loss of water molecule offers satisfactory sensitivity of determination.

High-resolution community profiling of arbuscular mycorrhizal fungi.

PubMed

Schlaeppi, Klaus; Bender, S Franz; Mascher, Fabio; Russo, Giancarlo; Patrignani, Andrea; Camenzind, Tessa; Hempel, Stefan; Rillig, Matthias C; van der Heijden, Marcel G A

2016-11-01

Community analyses of arbuscular mycorrhizal fungi (AMF) using ribosomal small subunit (SSU) or internal transcribed spacer (ITS) DNA sequences often suffer from low resolution or coverage. We developed a novel sequencing based approach for a highly resolving and specific profiling of AMF communities. We took advantage of previously established AMF-specific PCR primers that amplify a c. 1.5-kb long fragment covering parts of SSU, ITS and parts of the large ribosomal subunit (LSU), and we sequenced the resulting amplicons with single molecule real-time (SMRT) sequencing. The method was applicable to soil and root samples, detected all major AMF families and successfully discriminated closely related AMF species, which would not be discernible using SSU sequences. In inoculation tests we could trace the introduced AMF inoculum at the molecular level. One of the introduced strains almost replaced the local strain(s), revealing that AMF inoculation can have a profound impact on the native community. The methodology presented offers researchers a powerful new tool for AMF community analysis because it unifies improved specificity and enhanced resolution, whereas the drawback of medium sequencing throughput appears of lesser importance for low-diversity groups such as AMF. © 2016 The Authors. New Phytologist © 2016 New Phytologist Trust.

Computer-aided biochemical programming of synthetic microreactors as diagnostic devices.

PubMed

Courbet, Alexis; Amar, Patrick; Fages, François; Renard, Eric; Molina, Franck

2018-04-26

Biological systems have evolved efficient sensing and decision-making mechanisms to maximize fitness in changing molecular environments. Synthetic biologists have exploited these capabilities to engineer control on information and energy processing in living cells. While engineered organisms pose important technological and ethical challenges, de novo assembly of non-living biomolecular devices could offer promising avenues toward various real-world applications. However, assembling biochemical parts into functional information processing systems has remained challenging due to extensive multidimensional parameter spaces that must be sampled comprehensively in order to identify robust, specification compliant molecular implementations. We introduce a systematic methodology based on automated computational design and microfluidics enabling the programming of synthetic cell-like microreactors embedding biochemical logic circuits, or protosensors , to perform accurate biosensing and biocomputing operations in vitro according to temporal logic specifications. We show that proof-of-concept protosensors integrating diagnostic algorithms detect specific patterns of biomarkers in human clinical samples. Protosensors may enable novel approaches to medicine and represent a step toward autonomous micromachines capable of precise interfacing of human physiology or other complex biological environments, ecosystems, or industrial bioprocesses. © 2018 The Authors. Published under the terms of the CC BY 4.0 license.

Exploiting science? A systematic analysis of complementary and alternative medicine clinic websites' marketing of stem cell therapies.

PubMed

Murdoch, Blake; Zarzeczny, Amy; Caulfield, Timothy

2018-02-28

To identify the frequency and qualitative characteristics of stem cell-related marketing claims made on websites of clinics featuring common types of complementary and alternative medicine practitioners. The involvement of complementary and alternative medicine practitioners in the marketing of stem cell therapies and stem cell-related interventions is understudied. This research explores the extent to which they are involved and collaborate with medical professionals. This knowledge will help with identifying and evaluating potential policy responses to this growing market. Systematic website analysis. Global. US and English-language bias due to methodology. Representations made on clinic websites in relation to practitioner types, stem cell therapies and their targets, stem cell-related interventions. Statements about stem cell therapies relating to evidence of inefficacy, limited evidence of efficacy, general procedural risks, risks specific to the mode of therapy, regulatory status, experimental or unproven nature of therapy. Use of hype language (eg, language that exaggerates potential benefits). 243 websites offered stem cell therapies. Many websites advertised stem cell transplantation from multiple sources, such as adipose-derived (112), bone marrow-derived (100), blood-derived (28), umbilical cord-derived (26) and others. Plant stem cell-based treatments and products (20) were also advertised. Purposes for and targets of treatment included pain, physical injury, a wide range of diseases and illnesses, cosmetic concerns, non-cosmetic ageing, sexual enhancement and others. Medical doctors (130), chiropractors (53) and naturopaths (44) commonly work in the clinics we found to be offering stem cell therapies. Few clinic websites advertising stem cell therapies included important additional information, including statements about evidence of inefficacy (present on only 12.76% of websites), statements about limited evidence of efficacy (18.93%), statements of general risks (24.69%), statements of risks specific to the mode(s) of therapy (5.76%), statements as to the regulatory status of the therapies (30.86%) and statements that the therapy is experimental or unproven (33.33%). Hype language was noted (31.69%). Stem cell therapies and related interventions are marketed for a wide breadth of conditions and are being offered by complementary and alternative practitioners, often in conjunction with medical doctors. Consumer protection and truth-in-advertising regulation could play important roles in addressing misleading marketing practices in this area. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Editorial: Which Wei Wang?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sprouse, Gene D.

The APS journals receive manuscripts from scientists all over the world. For authors whose names cannot be expressed in Latin characters, their names in the byline must be transliterated, a process that is not necessarily bidirectionally unique. For example, the eight Chinese names all transliterate as Wei Wang. To remove some of the ambiguity arising from this unfortunate degeneracy of names, APS will allow some authors the option to include their names in their own language in parentheses after the transliterated name, such as Wei Wang. The option to present names in the article byline in this manner is anmore » experiment initially offered to Chinese, Japanese, and Korean authors, whose names can be expressed in Unicode characters. An example of a Japanese name is Tadanori Minamisono and a Korean name is Chang Kee Jung. In the English text the given name precedes the family name, while the reverse is true for the characters. As we gain experience, we may be able to broaden this offer to other languages. Authors who wish to try this option will need to prepare their manuscripts by following the special instructions at http://authors.aps.org/names.html.« less

Grade Validity of Online Quantitative Courses

ERIC Educational Resources Information Center

Faurer, Judson C.

2013-01-01

Are prospective employers getting "quality" educated, degreed applicants and are academic institutions that offer online degree programs ensuring the quality control of the courses/programs offered? The issue specifically addressed in this paper is not with all institutions offering degrees through online programs or even with all online…

Grade Validity of Online Quantitative Courses

ERIC Educational Resources Information Center

Faurer, Judson C.

2009-01-01

Are prospective employers getting "quality" educated degreed applicants and are academic institutions that offer online degree programs ensuring the quality control of the courses/programs offered? The issue specifically addressed in this paper is not with all institutions offering degrees through online programs or even with all online…

Nature-based agricultural solutions: Scaling perennial grains across Africa.

PubMed

Peter, Brad G; Mungai, Leah M; Messina, Joseph P; Snapp, Sieglinde S

2017-11-01

Modern plant breeding tends to focus on maximizing yield, with one of the most ubiquitous implementations being shorter-duration crop varieties. It is indisputable that these breeding efforts have resulted in greater yields in ideal circumstances; however, many farmed locations across Africa suffer from one or more conditions that limit the efficacy of modern short-duration hybrids. In view of global change and increased necessity for intensification, perennial grains and long-duration varieties offer a nature-based solution for improving farm productivity and smallholder livelihoods in suboptimal agricultural areas. Specific conditions where perennial grains should be considered include locations where biophysical and social constraints reduce agricultural system efficiency, and where conditions are optimal for crop growth. Using a time-series of remotely-sensed data, we locate the marginal agricultural lands of Africa, identifying suboptimal temperature and precipitation conditions for the dominant crop, i.e., maize, as well as optimal climate conditions for two perennial grains, pigeonpea and sorghum. We propose that perennial grains offer a lower impact, sustainable nature-based solution to this subset of climatic drivers of marginality. Using spatial analytic methods and satellite-derived climate information, we demonstrate the scalability of perennial pigeonpea and sorghum across Africa. As a nature-based solution, we argue that perennial grains offer smallholder farmers of marginal lands a sustainable solution for enhancing resilience and minimizing risk in confronting global change, while mitigating social and edaphic drivers of low and variable production. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.