Sample records for auto restricted zone

  1. Downtown Crossing: Auto Restricted Zone in Boston

    DOT National Transportation Integrated Search

    1982-07-01

    The Downtown Crossing auto restricted zone, implemented in 1978, involved the : elimination of all auto traffic froma zone of twelve blocks encompassing six : different streets in Bostn's central business district. Some of the blocks were : pedestria...

  2. The Implementation of Downtown Auto-Restricted Projects

    DOT National Transportation Integrated Search

    1984-06-01

    In 1975 UMTA's Office of Service and Methods Demonstration launched a demonstration program of Auto Restricted Zones (ARZs) which went beyond the traditional scope of linear pedestrian malls. ARZs involve auto restriction in a large geographic area w...

  3. Auto-Restricted Zone Demonstration in Memphis, TN

    DOT National Transportation Integrated Search

    1988-03-01

    The Service and Methods Demonstration conducted in downtown Memphis was one of 4 parallel demonstrations involving downtown auto-restricted zones (ARZs). Unlike the other three demonstrations (Boston, New York, and Providence), the Memphis ARZ was al...

  4. 76 FR 1065 - Security Zone; 23rd Annual North American International Auto Show, Detroit River, Detroit, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-07

    ...-AA87 Security Zone; 23rd Annual North American International Auto Show, Detroit River, Detroit, MI... officials at the 23rd Annual North American International Auto Show (NAIAS) being held at Cobo Hall in... 23rd Annual North American International Auto Show (NAIAS) being held at Cobo Hall in downtown Detroit...

  5. Impacts of building geometry modeling methods on the simulation results of urban building energy models

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chen, Yixing; Hong, Tianzhen

    We present that urban-scale building energy modeling (UBEM)—using building modeling to understand how a group of buildings will perform together—is attracting increasing attention in the energy modeling field. Unlike modeling a single building, which will use detailed information, UBEM generally uses existing building stock data consisting of high-level building information. This study evaluated the impacts of three zoning methods and the use of floor multipliers on the simulated energy use of 940 office and retail buildings in three climate zones using City Building Energy Saver. The first zoning method, OneZone, creates one thermal zone per floor using the target building'smore » footprint. The second zoning method, AutoZone, splits the building's footprint into perimeter and core zones. A novel, pixel-based automatic zoning algorithm is developed for the AutoZone method. The third zoning method, Prototype, uses the U.S. Department of Energy's reference building prototype shapes. Results show that simulated source energy use of buildings with the floor multiplier are marginally higher by up to 2.6% than those modeling each floor explicitly, which take two to three times longer to run. Compared with the AutoZone method, the OneZone method results in decreased thermal loads and less equipment capacities: 15.2% smaller fan capacity, 11.1% smaller cooling capacity, 11.0% smaller heating capacity, 16.9% less heating loads, and 7.5% less cooling loads. Source energy use differences range from -7.6% to 5.1%. When comparing the Prototype method with the AutoZone method, source energy use differences range from -12.1% to 19.0%, and larger ranges of differences are found for the thermal loads and equipment capacities. This study demonstrated that zoning methods have a significant impact on the simulated energy use of UBEM. Finally, one recommendation resulting from this study is to use the AutoZone method with floor multiplier to obtain accurate results while balancing the simulation run time for UBEM.« less

  6. Impacts of building geometry modeling methods on the simulation results of urban building energy models

    DOE PAGES

    Chen, Yixing; Hong, Tianzhen

    2018-02-20

    We present that urban-scale building energy modeling (UBEM)—using building modeling to understand how a group of buildings will perform together—is attracting increasing attention in the energy modeling field. Unlike modeling a single building, which will use detailed information, UBEM generally uses existing building stock data consisting of high-level building information. This study evaluated the impacts of three zoning methods and the use of floor multipliers on the simulated energy use of 940 office and retail buildings in three climate zones using City Building Energy Saver. The first zoning method, OneZone, creates one thermal zone per floor using the target building'smore » footprint. The second zoning method, AutoZone, splits the building's footprint into perimeter and core zones. A novel, pixel-based automatic zoning algorithm is developed for the AutoZone method. The third zoning method, Prototype, uses the U.S. Department of Energy's reference building prototype shapes. Results show that simulated source energy use of buildings with the floor multiplier are marginally higher by up to 2.6% than those modeling each floor explicitly, which take two to three times longer to run. Compared with the AutoZone method, the OneZone method results in decreased thermal loads and less equipment capacities: 15.2% smaller fan capacity, 11.1% smaller cooling capacity, 11.0% smaller heating capacity, 16.9% less heating loads, and 7.5% less cooling loads. Source energy use differences range from -7.6% to 5.1%. When comparing the Prototype method with the AutoZone method, source energy use differences range from -12.1% to 19.0%, and larger ranges of differences are found for the thermal loads and equipment capacities. This study demonstrated that zoning methods have a significant impact on the simulated energy use of UBEM. Finally, one recommendation resulting from this study is to use the AutoZone method with floor multiplier to obtain accurate results while balancing the simulation run time for UBEM.« less

  7. 46 CFR 167.65-35 - Use of auto pilot.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Use of auto pilot. 167.65-35 Section 167.65-35 Shipping... Special Operating Requirements § 167.65-35 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used in— (a) Areas of high traffic density; (b) Conditions of restricted...

  8. Development of 40-in hybrid hologram screen for auto-stereoscopic video display

    NASA Astrophysics Data System (ADS)

    Song, Hyun Ho; Nakashima, Y.; Momonoi, Y.; Honda, Toshio

    2004-06-01

    Usually in auto stereoscopic display, there are two problems. The first problem is that large image display is difficult, and the second problem is that the view zone (which means the zone in which both eyes are put for stereoscopic or 3-D image observation) is very narrow. We have been developing an auto stereoscopic large video display system (over 100 inches diagonal) which a few people can view simultaneously1,2. Usually in displays that are over 100 inches diagonal, an optical video projection system is used. As one of auto stereoscopic display systems the hologram screen has been proposed3,4,5,6. However, if the hologram screen becomes too large, the view zone (corresponding to the reconstructed diffused object) causes color dispersion and color aberration7. We also proposed the additional Fresnel lens attached to the hologram screen. We call the screen a "hybrid hologram screen", (HHS in short). We made the HHS 866mm(H)×433mm(V) (about 40 inch diagonal)8,9,10,11. By using the lens in the reconstruction step, the angle between object light and reference light can be small, compared to without the lens. So, the spread of the view zone by the color dispersion and color aberration becomes small. And also, the virtual image which is reconstructed from the hologram screen can be transformed to a real image (view zone). So, it is not necessary to use a large lens or concave mirror while making a large hologram screen.

  9. Proteolysis breaks tolerance toward intact α345(IV) collagen, eliciting novel anti-GBM autoantibodies specific for α345NC1 hexamers

    PubMed Central

    Olaru, Florina; Wang, Xu-Ping; Luo, Wentian; Ge, Linna; Miner, Jeffrey H; Kleinau, Sandra; Geiger, Xochiquetzal J.; Wasiluk, Andrew; Heidet, Laurence; Kitching, A. Richard; Borza, Dorin-Bogdan

    2012-01-01

    Goodpasture disease is an autoimmune kidney disease mediated by autoAbs against NC1 monomers of α3(IV) collagen that bind to the glomerular basement membrane (GBM), usually causing rapidly progressive glomerulonephritis. We identified a novel type of human IgG4-restricted anti-GBM autoAbs associated with mild non-progressive glomerulonephritis, which specifically targeted α345NC1 hexamers but not α3NC1 monomers. The mechanisms eliciting these anti-GBM autoAbs were investigated in mouse models recapitulating this phenotype. Wild type and FcγRIIB−/− mice immunized with autologous murine GBM NC1 hexamers produced mouse IgG1-restricted autoAbs specific for α345NC1 hexamers, which bound to the GBM in vivo but did not cause glomerulonephritis. In these mice, intact collagen IV from murine GBM was not immunogenic. However, in Col4a3−/− Alport mice, both intact collagen IV and NC1 hexamers from murine GBM elicited IgG antibodies specific for α3α4α5NC1 hexamers, which were not subclass restricted. As heterologous antigen in COL4A3-humanized mice, murine GBM NC1 hexamers elicited mouse IgG1, IgG2a and IgG2b autoAbs specific for α345NC1 hexamers and induced anti-GBM Ab glomerulonephritis. These findings indicate that tolerance toward autologous intact α3α4α5(IV) collagen is established in hosts expressing this antigen, even though autoreactive B cells specific for α345NC1 hexamers are not purged from their repertoire. Proteolysis selectively breaches this tolerance by generating autoimmunogenic α3α4α5NC1 hexamers. This provides a mechanism eliciting autoAbs specific for α345NC1 hexamers, which are restricted to non-inflammatory IgG subclasses and non-nephritogenic. In Alport syndrome, lack of tolerance toward α3α4α5(IV) collagen promotes production of alloantibodies to α345NC1 hexamers, including pro-inflammatory IgG subclasses which mediate post-transplant anti-GBM nephritis. PMID:23303673

  10. 77 FR 2453 - Security Zone; 24th Annual North American International Auto Show, Detroit River, Detroit, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-18

    ... Docket Management Facility (M-30), U.S. Department of Transportation, West Building Ground Floor, Room.... The security zone will encompass an area of the Detroit River beginning at a point of origin on land... shoreline to connect back to the point of origin. Vessels in close proximity to the security zone will be...

  11. 19 CFR 146.44 - Zone-restricted status.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Zone-restricted status. 146.44 Section 146.44... TREASURY (CONTINUED) FOREIGN TRADE ZONES Status of Merchandise in a Zone § 146.44 Zone-restricted status. (a) General. Merchandise taken into a zone for the sole purpose of exportation, destruction (except...

  12. 19 CFR 146.70 - Transfer of zone-restricted merchandise into Customs territory.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Transfer of zone-restricted merchandise into... HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.70 Transfer of zone-restricted merchandise into Customs territory. (a) General. Zone...

  13. 19 CFR 146.70 - Transfer of zone-restricted merchandise into Customs territory.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Transfer of zone-restricted merchandise into... HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.70 Transfer of zone-restricted merchandise into Customs territory. (a) General. Zone...

  14. 19 CFR 146.70 - Transfer of zone-restricted merchandise into Customs territory.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Transfer of zone-restricted merchandise into... HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.70 Transfer of zone-restricted merchandise into Customs territory. (a) General. Zone...

  15. 19 CFR 146.70 - Transfer of zone-restricted merchandise into Customs territory.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Transfer of zone-restricted merchandise into... HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.70 Transfer of zone-restricted merchandise into Customs territory. (a) General. Zone...

  16. 19 CFR 146.70 - Transfer of zone-restricted merchandise into Customs territory.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Transfer of zone-restricted merchandise into... HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.70 Transfer of zone-restricted merchandise into Customs territory. (a) General. Zone...

  17. A new predictive multi-zone model for HCCI engine combustion

    DOE PAGES

    Bissoli, Mattia; Frassoldati, Alessio; Cuoci, Alberto; ...

    2016-06-30

    Here, this work introduces a new predictive multi-zone model for the description of combustion in Homogeneous Charge Compression Ignition (HCCI) engines. The model exploits the existing OpenSMOKE++ computational suite to handle detailed kinetic mechanisms, providing reliable predictions of the in-cylinder auto-ignition processes. All the elements with a significant impact on the combustion performances and emissions, like turbulence, heat and mass exchanges, crevices, residual burned gases, thermal and feed stratification are taken into account. Compared to other computational approaches, this model improves the description of mixture stratification phenomena by coupling a wall heat transfer model derived from CFD application with amore » proper turbulence model. Furthermore, the calibration of this multi-zone model requires only three parameters, which can be derived from a non-reactive CFD simulation: these adaptive variables depend only on the engine geometry and remain fixed across a wide range of operating conditions, allowing the prediction of auto-ignition, pressure traces and pollutants. This computational framework enables the use of detail kinetic mechanisms, as well as Rate of Production Analysis (RoPA) and Sensitivity Analysis (SA) to investigate the complex chemistry involved in the auto-ignition and the pollutants formation processes. In the final sections of the paper, these capabilities are demonstrated through the comparison with experimental data.« less

  18. Structure of the North Anatolian Fault Zone from the Auto-Correlation of Ambient Seismic Noise Recorded at a Dense Seismometer Array

    NASA Astrophysics Data System (ADS)

    Taylor, D. G.; Rost, S.; Houseman, G.

    2015-12-01

    In recent years the technique of cross-correlating the ambient seismic noise wavefield at two seismometers to reconstruct empirical Green's Functions for the determination of Earth structure has been a powerful tool to study the Earth's interior without earthquake or man-made sources. However, far less attention has been paid to using auto-correlations of seismic noise to reveal body wave reflections from interfaces in the subsurface. In principle, the Green's functions thus derived should be comparable to the Earth's impulse response to a co-located source and receiver. We use data from a dense seismic array (Dense Array for Northern Anatolia - DANA) deployed across the northern branch of the North Anatolian Fault Zone (NAFZ) in the region of the 1999 magnitude 7.6 Izmit earthquake in western Turkey. The NAFZ is a major strike-slip system that extends ~1200 km across northern Turkey and continues to pose a high level of seismic hazard, in particular to the mega-city of Istanbul. We construct reflection images for the entire crust and upper mantle over the ~35 km by 70 km footprint of the 70-station DANA array. Using auto-correlations of vertical and horizontal components of ground motion, both P- and S-wave velocity information can be retrieved from the wavefield to constrain crustal structure further to established methods. We show that clear P-wave reflections from the crust-mantle boundary (Moho) can be retrieved using the autocorrelation technique, indicating topography on the Moho on horizontal scales of less than 10 km. Offsets in crustal structure can be identified that seem to be correlated with the surface expression of the fault zone in the region. The combined analysis of auto-correlations using vertical and horizontal components will lead to further insight into the fault zone structure throughout the crust and upper mantle.

  19. Delineation of typhoon-induced shoreline changes in Taiwan

    NASA Astrophysics Data System (ADS)

    Lin, Yun-Bin; Chiang, Jie-Lun

    2010-05-01

    Taiwan, an island country located at the southwestern Pacific Ocean, has a coast line of 1,355 km long. And only 55% proportion of the coast line remains natural. The maximum daily accumulated rainfall over 1000 mm brought by the typhoon Mindulle in 2004 generated huge disaster, including a broad flood-prone area and a sick sedimentation, in the littoral zones of the low-latitude part of Taiwan. The event resulted in the official definition of the coastal area, which is a 9 km wide belt area surrounding Taiwan island and is composed of one third land area and two third sea area. And human constructions are restricted in the proposed coast area to prevent or reduce the possible disaster in the future. Not only the sea level rising induced by the global climate warming may seriously affect the littoral zones, but also the extreme climate accompanying with the global climate warming, such as typhoons and storms, can heavily disturb the coastal environment in Taiwan. In the storm area, the wave and the storm surge may induce the coast erosion. But even being outside the storm area, the coastal environment is still regularly influenced by the sediment transportation triggered by the storm in the Cainozoic zones in the central part of Taiwan. Therefore, the continuous and regular monitoring of shoreline changes is essential for the disaster management in Taiwan. The two dimensional Morlet wavelet analysis is used to detect edges on synthetic aperture radar (SAR) images. And a block tracing algorithm and an active contour model are integrated for the final shorelines auto-delineation in the study. The SAR image that is climate unaffected and is free of visible light can provide reliable information. The Morlet wavelet function has the smallest window size and is directional. Therefore, the Morlet wavelet function is more flexible and efficient in extracting specific information from image signals. The shoreline changes induced by the typhoon Mindulle were studied. The outcome that is well coincided with the result of a field survey can be obtained in a more efficient way. Keywords: shoreline, auto-delineation, wavelet analysis, SAR

  20. 24 CFR 200.72 - Zoning, deed and building restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Zoning, deed and building... Zoning, deed and building restrictions. The project when completed shall not violate any material zoning or deed restrictions applicable to the project site, and shall comply with all applicable building...

  1. Assessment of underground water potential zones using modern geomatics technologies in Jhansi district, Uttar Pradesh, India.

    NASA Astrophysics Data System (ADS)

    Pandey, N. K.; Shukla, A. K.; Shukla, S.; Pandey, M.

    2014-11-01

    Ground water is a distinguished component of the hydrologic cycle. Surface water storage and ground water withdrawal are traditional engineering approaches which will continue to be followed in the future. The uncertainty about the occurrence, distribution and quality aspect of the ground water and the energy requirement for its withdrawal impose restriction on exploitation of ground water. The main objective of the study is assessment of underground water potential zones of Jhansi city and surrounding area, by preparing underground water potential zone map using Geographical Information System (GIS), remote sensing, and validation by underground water inventory mapping using GPS field survey done along the parts of National Highway 25 and 26 and some state highway passing through the study area. Study area covers an area of 1401 km2 and its perimeter is approximate 425 km. For this study Landsat TM (0.76-0.90 um) band data were acquired from GLCF website. Sensor spatial resolution is 30 m. Satellite image has become a standard tool aiding in the study of underground water. Extraction of different thematic layers like Land Use Land Cover (LULC), settlement, etc. can be done through unsupervised classification. The modern geometics technologies viz. remote sensing and GIS are used to produce the map that classifies the groundwater potential zone to a number of qualitative zone such as very high, high, moderate, low or very low. Thematic maps are prepared by visual interpretation of Survey of India topo-sheets and linearly enhanced Landsat TM satellite image on 1 : 50,000 scale using AutoCAD, ArcGIS 10.1 and ERDAS 11 software packages.

  2. 46 CFR 167.65-35 - Use of auto pilot.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... the automatic pilot is used in— (a) Areas of high traffic density; (b) Conditions of restricted... possible to immediately establish human control of the ship's steering: (2) A competent person is ready at...

  3. 46 CFR 167.65-35 - Use of auto pilot.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... the automatic pilot is used in— (a) Areas of high traffic density; (b) Conditions of restricted... possible to immediately establish human control of the ship's steering: (2) A competent person is ready at...

  4. 46 CFR 167.65-35 - Use of auto pilot.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... the automatic pilot is used in— (a) Areas of high traffic density; (b) Conditions of restricted... possible to immediately establish human control of the ship's steering: (2) A competent person is ready at...

  5. 15 CFR 400.44 - Zone-restricted merchandise.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Zone-restricted merchandise. 400.44 Section 400.44 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) FOREIGN-TRADE ZONES BOARD, DEPARTMENT OF COMMERCE REGULATIONS OF THE FOREIGN-TRADE ZONES BOARD Zone...

  6. 19 CFR 146.64 - Entry for warehouse.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.64 Entry for warehouse. (a) Foreign... status may not be entered for warehouse from a zone. Merchandise in nonprivileged foreign status... different port. (b) Zone-restricted merchandise. Foreign merchandise in zone-restricted status may be...

  7. An auto-bias control scheme for IQ-modulator with various modulation formats

    NASA Astrophysics Data System (ADS)

    Zhang, Wenqi; Yuan, Xueguang; Zhang, Yang'an

    2016-10-01

    We propose and demonstrate an auto-bias control scheme for the IQ-modulator of a flexible optical PSK or QAM or other modulation formats transmitter in this paper. Due to IQ-modulators usually producing higher-order modulation format, these modulation formats involve phase mostly. It is based on that the bias drift will change the operating point and result in varying the output optical phase. This technology has no restrictions on modulation formats, so it has good flexibility. The experimental result show the three biases can be stabilized when the proposed scheme is implemented.

  8. 9 CFR 98.38 - Restrictions on the importation of swine semen from the APHIS-defined EU CSF region.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... competent veterinary authority of the APHIS-defined EU CSF region Member State. (b) The semen must not have... designation of the zone as a restricted zone is removed by the competent veterinary authority of the Member... restricted zone is removed by the competent veterinary authority of the Member State. (c) The semen must not...

  9. 23 CFR 660.103 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... jurisdiction and maintenance responsibility for a FH. Forest highway means a forest road under the jurisdiction of, and maintained by, a public authority and open to public travel. Forest road means a road wholly... passenger auto, without restrictive gates or prohibitive signs or regulations, other than for general...

  10. 23 CFR 660.103 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... jurisdiction and maintenance responsibility for a FH. Forest highway means a forest road under the jurisdiction of, and maintained by, a public authority and open to public travel. Forest road means a road wholly... passenger auto, without restrictive gates or prohibitive signs or regulations, other than for general...

  11. 23 CFR 660.103 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... jurisdiction and maintenance responsibility for a FH. Forest highway means a forest road under the jurisdiction of, and maintained by, a public authority and open to public travel. Forest road means a road wholly... passenger auto, without restrictive gates or prohibitive signs or regulations, other than for general...

  12. 23 CFR 660.103 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... jurisdiction and maintenance responsibility for a FH. Forest highway means a forest road under the jurisdiction of, and maintained by, a public authority and open to public travel. Forest road means a road wholly... passenger auto, without restrictive gates or prohibitive signs or regulations, other than for general...

  13. 33 CFR 334.430 - Neuse River and tributaries at Marine Corps Air Station Cherry Point, North Carolina; restricted...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Marine Corps Air Station Cherry Point, North Carolina; restricted area and danger zone. 334.430 Section... Air Station Cherry Point, North Carolina; restricted area and danger zone. (a) The restricted area... Station, Cherry Point, North Carolina, extending from the mouth of Hancock Creek to a point approximately...

  14. 33 CFR 334.500 - St. Johns River, Atlantic Ocean, Sherman Creek; restricted areas and danger zone, Naval Station...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false St. Johns River, Atlantic Ocean... AND RESTRICTED AREA REGULATIONS § 334.500 St. Johns River, Atlantic Ocean, Sherman Creek; restricted areas and danger zone, Naval Station Mayport, Florida. (a) The areas. (1) The St. Johns River restricted...

  15. Violations of temporary flight restrictions and air defense identification zones : an analysis of airspace violations and pilot report data

    DOT National Transportation Integrated Search

    2005-09-30

    This document provides the results from a study into the apparent factors and causes of violations of restricted airspace, particularly temporary flight restrictions (TFRs) and air defense identification zones (ADIZs). By illuminating the reasons for...

  16. Characteristics of AZ31 Mg alloy joint using automatic TIG welding

    NASA Astrophysics Data System (ADS)

    Liu, Hong-tao; Zhou, Ji-xue; Zhao, Dong-qing; Liu, Yun-teng; Wu, Jian-hua; Yang, Yuan-sheng; Ma, Bai-chang; Zhuang, Hai-hua

    2017-01-01

    The automatic tungsten-inert gas welding (ATIGW) of AZ31 Mg alloys was performed using a six-axis robot. The evolution of the microstructure and texture of the AZ31 auto-welded joints was studied by optical microscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and electron backscatter diffraction. The ATIGW process resulted in coarse recrystallized grains in the heat affected zone (HAZ) and epitaxial growth of columnar grains in the fusion zone (FZ). Substantial changes of texture between the base material (BM) and the FZ were detected. The {0002} basal plane in the BM was largely parallel to the sheet rolling plane, whereas the c-axis of the crystal lattice in the FZ inclined approximately 25° with respect to the welding direction. The maximum pole density increased from 9.45 in the BM to 12.9 in the FZ. The microhardness distribution, tensile properties, and fracture features of the AZ31 auto-welded joints were also investigated.

  17. 15 CFR 400.33 - Restrictions on manufacturing and processing activity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...-TRADE ZONES BOARD Manufacturing and Processing Activity-Reviews § 400.33 Restrictions on manufacturing and processing activity. (a) In general. In approving manufacturing or processing activity for a zone... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Restrictions on manufacturing and...

  18. 33 CFR 334.610 - Key West Harbor, at U.S. Naval Base, Key West, Fla.; naval restricted areas and danger zone.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Key West Harbor, at U.S. Naval Base, Key West, Fla.; naval restricted areas and danger zone. 334.610 Section 334.610 Navigation and... RESTRICTED AREA REGULATIONS § 334.610 Key West Harbor, at U.S. Naval Base, Key West, Fla.; naval restricted...

  19. 33 CFR 334.610 - Key West Harbor, at U.S. Naval Base, Key West, Fla.; naval restricted areas and danger zone.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Key West Harbor, at U.S. Naval Base, Key West, Fla.; naval restricted areas and danger zone. 334.610 Section 334.610 Navigation and... RESTRICTED AREA REGULATIONS § 334.610 Key West Harbor, at U.S. Naval Base, Key West, Fla.; naval restricted...

  20. 33 CFR 334.610 - Key West Harbor, at U.S. Naval Base, Key West, Fla.; naval restricted areas and danger zone.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Key West Harbor, at U.S. Naval Base, Key West, Fla.; naval restricted areas and danger zone. 334.610 Section 334.610 Navigation and... RESTRICTED AREA REGULATIONS § 334.610 Key West Harbor, at U.S. Naval Base, Key West, Fla.; naval restricted...

  1. 33 CFR 334.610 - Key West Harbor, at U.S. Naval Base, Key West, Fla.; naval restricted areas and danger zone.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Key West Harbor, at U.S. Naval Base, Key West, Fla.; naval restricted areas and danger zone. 334.610 Section 334.610 Navigation and... RESTRICTED AREA REGULATIONS § 334.610 Key West Harbor, at U.S. Naval Base, Key West, Fla.; naval restricted...

  2. Cross index for improving cloning selectivity by partially filling in 5'-extensions of DNA produced by type II restriction endonucleases.

    PubMed Central

    Korch, C

    1987-01-01

    A cross index is presented for using the improved selectivity offered by the Hung and Wensink (Nucl. Acids Res. 12, 1863-1874, 1984) method of partially filling in 5'-extensions produced by type II restriction endonucleases. After this treatment, DNA fragments which normally cannot be ligated to one another, can be joined providing that complementary cohesive ends have been generated. The uses of this technique, which include the prevention of DNA fragments (both vector and insert) auto-annealing, are discussed. PMID:3033600

  3. Deep Drilling and Sampling via the Wireline Auto-Gopher Driven by Piezoelectric Percussive Actuator and EM Rotary Motor

    NASA Technical Reports Server (NTRS)

    Bar-Cohen, Yoseph; Badescu, Mircea; Sherrit, Stewart; Zacny, Kris; Paulsen, Gale L; Beegle, Luther; Bao, Xiaoqi

    2012-01-01

    The ability to penetrate subsurfaces and perform sample acquisition at depths of meters is critical for future NASA in-situ exploration missions to bodies in the solar system, including Mars and Europa. A corer/sampler was developed with the goal of acquiring pristine samples by reaching depths on Mars beyond the oxidized and sterilized zone. To developed rotary-hammering coring drill, called Auto-Gopher, employs a piezoelectric actuated percussive mechanism for breaking formations and an electric motor rotates the bit to remove the powdered cuttings. This sampler is a wireline mechanism that is incorporated with an inchworm mechanism allowing thru cyclic coring and core removal to reach great depths. The penetration rate is being optimized by simultaneously activating the percussive and rotary motions of the Auto-Gopher. The percussive mechanism is based on the Ultrasonic/Sonic Drill/Corer (USDC) mechanism that is driven by piezoelectric stack and that was demonstrated to require low axial preload. The Auto-Gopher has been produced taking into account the a lessons learned from the development of the Ultrasonic/Sonic Gopher that was designed as a percussive ice drill and was demonstrated in Antarctica in 2005 to reach about 2 meters deep. A field demonstration of the Auto-Gopher is currently being planned with objective of reaching as deep as 3 to 5 meters in tufa subsurface.

  4. 38 CFR 21.4201 - Restrictions on enrollment; percentage of students receiving financial support.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... technology or auto mechanics certificate) and other associate degree courses where a field is specified must... established, organized and operated pursuant to regulations of a military department of the Armed Forces as... offered under contract with the Department of Defense, (ii) Is on or immediately adjacent to a military...

  5. 38 CFR 21.4201 - Restrictions on enrollment; percentage of students receiving financial support.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... technology or auto mechanics certificate) and other associate degree courses where a field is specified must... established, organized and operated pursuant to regulations of a military department of the Armed Forces as... offered under contract with the Department of Defense, (ii) Is on or immediately adjacent to a military...

  6. 38 CFR 21.4201 - Restrictions on enrollment; percentage of students receiving financial support.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... technology or auto mechanics certificate) and other associate degree courses where a field is specified must... established, organized and operated pursuant to regulations of a military department of the Armed Forces as... offered under contract with the Department of Defense, (ii) Is on or immediately adjacent to a military...

  7. Numerical simulation and validation of SI-CAI hybrid combustion in a CAI/HCCI gasoline engine

    NASA Astrophysics Data System (ADS)

    Wang, Xinyan; Xie, Hui; Xie, Liyan; Zhang, Lianfang; Li, Le; Chen, Tao; Zhao, Hua

    2013-02-01

    SI-CAI hybrid combustion, also known as spark-assisted compression ignition (SACI), is a promising concept to extend the operating range of CAI (Controlled Auto-Ignition) and achieve the smooth transition between spark ignition (SI) and CAI in the gasoline engine. In this study, a SI-CAI hybrid combustion model (HCM) has been constructed on the basis of the 3-Zones Extended Coherent Flame Model (ECFM3Z). An ignition model is included to initiate the ECFM3Z calculation and induce the flame propagation. In order to precisely depict the subsequent auto-ignition process of the unburned fuel and air mixture independently after the initiation of flame propagation, the tabulated chemistry concept is adopted to describe the auto-ignition chemistry. The methodology for extracting tabulated parameters from the chemical kinetics calculations is developed so that both cool flame reactions and main auto-ignition combustion can be well captured under a wider range of thermodynamic conditions. The SI-CAI hybrid combustion model (HCM) is then applied in the three-dimensional computational fluid dynamics (3-D CFD) engine simulation. The simulation results are compared with the experimental data obtained from a single cylinder VVA engine. The detailed analysis of the simulations demonstrates that the SI-CAI hybrid combustion process is characterised with the early flame propagation and subsequent multi-site auto-ignition around the main flame front, which is consistent with the optical results reported by other researchers. Besides, the systematic study of the in-cylinder condition reveals the influence mechanism of the early flame propagation on the subsequent auto-ignition.

  8. Parametric Method to Define Area of Allowable Configurations while Changing Position of Restricted Zones

    NASA Astrophysics Data System (ADS)

    Pritykin, F. N.; Nefedov, D. I.; Rogoza, Yu A.; Zinchenko, Yu V.

    2018-03-01

    The article presents the findings related to the development of the module for automatic collision detection of the manipulator with restricted zones for virtual motion modeling. It proposes the parametric method for specifying the area of allowable joint configurations. The authors study the cases when restricted zones are specified using the horizontal plane or front-projection planes. The joint coordinate space is specified by rectangular axes in the direction of which the angles defining the displacements in turning pairs are laid off. The authors present the results of modeling which enabled to develop a parametric method for specifying a set of cross-sections defining the shape and position of allowable configurations in different positions of a restricted zone. All joint points that define allowable configurations refer to the indicated sections. The area of allowable configurations is specified analytically by using several kinematic surfaces that limit it. A geometric analysis is developed based on the use of the area of allowable configurations characterizing the position of the manipulator and reported restricted zones. The paper presents numerical calculations related to virtual simulation of the manipulator path performed by the mobile robot Varan when using the developed algorithm and restricted zones. The obtained analytical dependencies allow us to define the area of allowable configurations, which is a knowledge pool to ensure the intelligent control of the manipulator path in a predefined environment. The use of the obtained region to synthesize a joint trajectory makes it possible to correct the manipulator path to foresee and eliminate deadlocks when synthesizing motions along the velocity vector.

  9. 33 CFR 334.500 - St. Johns River, Atlantic Ocean, Sherman Creek; restricted areas and danger zone, Naval Station...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... north by Perimeter Road, and on the east by Mayport Road. (5) Danger zone. The danger zone shall... hours a day, seven days a week. Warning signs notifying individuals of the restricted area boundary and... will be in place 24 hours a day, seven days a week. Warning signs notifying individuals of the...

  10. 78 FR 21101 - Certain Steel Threaded Rod From the People's Republic of China: Preliminary Results of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-09

    .... Ltd. PSGT Trading Jingjiang Ltd. Qingdao Free Trade Zone Health Intl. Shanghai East Best Foreign Trade...) Shanghai Furen International Trading; and (5) Shanghai Printing and Packaging Machinery Corp. No other... International Trading Co. Ningbo Qunli Fastener Manufacture Co., Ltd. Ningbo Shuanglin Auto Parts Co., Ltd...

  11. Byers Auto Group: A Case Study Into The Economics, Zoning, and Overall Process of Installing Small Wind Turbines at Two Automotive Dealerships in Ohio

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Oteri, F.; Sinclair, K.

    This paper provides the talking points about a case study on the installation of a $600,000 small wind project, the installation process, estimated annual energy production and percentage of energy needs met by the turbines.

  12. Byers Auto Group: A Case Study Into The Economics, Zoning, and Overall Process of Installing Small Wind Turbines at Two Automotive Dealerships in Ohio (Presentation)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sinclair, K.; Oteri, F.

    This presentation provides the talking points about a case study on the installation of a $600,000 small wind project, the installation process, estimated annual energy production and percentage of energy needs met by the turbines.

  13. Preoperative TRAM free flap volume estimation for breast reconstruction in lean patients.

    PubMed

    Minn, Kyung Won; Hong, Ki Yong; Lee, Sang Woo

    2010-04-01

    To obtain pleasing symmetry in breast reconstruction with transverse rectus abdominis myocutaneous (TRAM) free flap, a large amount of abdominal flap is elevated and remnant tissue is trimmed in most cases. However, elevation of abundant abdominal flap can cause excessive tension in donor site closure and increase the possibility of hypertrophic scarring especially in lean patients. The TRAM flap was divided into 4 zones in routine manner; the depth and dimension of the 4 zones were obtained using ultrasound and AutoCAD (Autodesk Inc., San Rafael, CA), respectively. The acquired numbers were then multiplied to obtain an estimate of volume of each zone and the each zone volume was added. To confirm the relation between the estimated volume and the actual volume, authors compared intraoperative actual TRAM flap volumes with preoperative estimated volumes in 30 consecutive TRAM free flap breast reconstructions. The estimated volumes and the actual elevated volumes of flap were found to be correlated by regression analysis (r = 0.9258, P < 0.01). According to this result, we could confirm the reliability of the preoperative volume estimation using our method. Afterward, the authors applied this method to 7 lean patients by estimation and revision of the design and obtained symmetric results with minimal donor site morbidity. Preoperative estimation of TRAM flap volume with ultrasound and AutoCAD (Autodesk Inc.) allow the authors to attain the precise volume desired for elevation. This method provides advantages in terms of minimal flap trimming, easier closure of donor sites, reduced scar widening and symmetry, especially in lean patients.

  14. Weak Compliance Undermines the Success of No-Take Zones in a Large Government-Controlled Marine Protected Area

    PubMed Central

    Campbell, Stuart J.; Hoey, Andrew S.; Maynard, Jeffrey; Kartawijaya, Tasrif; Cinner, Joshua; Graham, Nicholas A. J.; Baird, Andrew H.

    2012-01-01

    The effectiveness of marine protected areas depends largely on whether people comply with the rules. We quantified temporal changes in benthic composition, reef fish biomass, and fishing effort among marine park zones (including no-take areas) to assess levels of compliance following the 2005 rezoning of the government-controlled Karimunjawa National Park (KNP), Indonesia. Four years after the rezoning awareness of fishing regulations was high amongst local fishers, ranging from 79.5±7.9 (SE) % for spatial restrictions to 97.7±1.2% for bans on the use of poisons. Despite this high awareness and strong compliance with gear restrictions, compliance with spatial restrictions was weak. In the four years following the rezoning reef fish biomass declined across all zones within KNP, with >50% reduction within the no-take Core and Protection Zones. These declines were primarily driven by decreases in the biomass of groups targeted by local fishers; planktivores, herbivores, piscivores, and invertivores. These declines in fish biomass were not driven by changes in habitat quality; coral cover increased in all zones, possibly as a result of a shift in fishing gears from those which can damage reefs (i.e., nets) to those which cause little direct damage (i.e., handlines and spears). Direct observations of fishing activities in 2009 revealed there was limited variation in fishing effort between zones in which fishing was allowed or prohibited. The apparent willingness of the KNP communities to comply with gear restrictions, but not spatial restrictions is difficult to explain and highlights the complexities of the social and economic dynamics that influence the ecological success of marine protected areas. Clearly the increased and high awareness of fishery restrictions following the rezoning is a positive step. The challenge now is to understand and foster the conditions that may facilitate compliance with spatial restrictions within KNP and marine parks worldwide. PMID:23226237

  15. Effect of a School Choice Policy Change on Active Commuting to Elementary School.

    PubMed

    Sirard, John R; McDonald, Kelsey; Mustain, Patrick; Hogan, Whitney; Helm, Alison

    2015-01-01

    The purposes of this study were to assess the effect of restricting school choice on changes in travel distance to school and transportation mode for elementary school students. Study design was pre-post (spring 2010-fall 2010) quasi-experimental. Study setting was all public elementary schools in Minneapolis, Minnesota. Subjects comprised approximately 20,500 students across 39 schools. Study assessed a school choice policy change that restricted school choice to a school closer to the family's home. School district transportation data were used to determine distance to school. Direct observations of student travel modes (two morning and two afternoon commutes at each time point) were used to assess transportation mode. Chi-square and independent-sample t-tests were calculated to describe the schools. Repeated measures general linear models were used to assess changes in travel distance to school and observed commuting behavior. Distance to school significantly decreased (1.83 ± .48 miles to 1.74 ± .46 miles; p = .002). We failed to observe any significant changes in morning (+.7%) or afternoon (-.7%) active commuting (both p = .08) or the number of automobiles in the morning (-7 autos per school; p = .06) or afternoon (+3 autos per school; p = .14). The more restrictive school choice policy decreased distance to school but had no significant effect on active commuting. Policy interventions designed to increase active commuting to school may require additional time to gain traction and programmatic support to induce changes in behavior.

  16. What's in a Name? For A Million Bucks or So, You can Name that School

    ERIC Educational Resources Information Center

    Altbach, Philip G.

    2006-01-01

    Although "naming rights" have proliferated in American higher education for the past several decades, the phenomenon has recently expanded to extraordinary lengths. In this area, academe fits right in with the larger culture, which has named everything from AutoZone Park to Gillette Stadium to the children's wing of your local hospital. Anything…

  17. 77 FR 76411 - Security Zone; 25th Annual North American International Auto Show, Detroit River, Detroit, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... provision authorizes an agency to issue a rule without prior notice and opportunity to comment when the... in the world for more than twenty-five years, and has been at the same location since 1965. In light... downtown Detroit, MI. The NAIAS is the prime venue for introducing the world's most anticipated vehicles...

  18. 19 CFR 146.63 - Entry for consumption.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... TREASURY (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.63 Entry for consumption... status may be entered for consumption from a zone. (b) Zone-restricted merchandise. Merchandise in a zone... otherwise changed in a zone (exclusive of packing) to its physical condition as entered within 24 hours...

  19. 19 CFR 146.63 - Entry for consumption.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... TREASURY (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.63 Entry for consumption... status may be entered for consumption from a zone. (b) Zone-restricted merchandise. Merchandise in a zone... otherwise changed in a zone (exclusive of packing) to its physical condition as entered within 24 hours...

  20. 19 CFR 146.63 - Entry for consumption.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... TREASURY (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.63 Entry for consumption... status may be entered for consumption from a zone. (b) Zone-restricted merchandise. Merchandise in a zone... otherwise changed in a zone (exclusive of packing) to its physical condition as entered within 24 hours...

  1. 19 CFR 146.63 - Entry for consumption.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.63 Entry for consumption... status may be entered for consumption from a zone. (b) Zone-restricted merchandise. Merchandise in a zone... otherwise changed in a zone (exclusive of packing) to its physical condition as entered within 24 hours...

  2. 19 CFR 146.63 - Entry for consumption.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... TREASURY (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.63 Entry for consumption... status may be entered for consumption from a zone. (b) Zone-restricted merchandise. Merchandise in a zone... otherwise changed in a zone (exclusive of packing) to its physical condition as entered within 24 hours...

  3. Environmental Assessment: For Joint Biological Point Detection System (JBPDS) at Multiple Test Ranges, Eglin Air Force Base, Florida

    DTIC Science & Technology

    2003-06-01

    bed. This clay layer restricts the downward migration of pollutants and restricts saline water from Choctawhatchee Bay and the Gulf of Mexico from...Because it is saline , the Lower Limestone unit is not used as a water source (U.S. Air Force, 1995). Groundwater storage and movement in the Upper... purslane , among others. Inland from the produne zone is the “scrub” zone. Vegetation found in this zone is usually stunted and wind/salt sprayed

  4. Geoelectric characteristics of portions of the Raha fault zone and surrounding rocks, Jabal As Silsilah Quadrangle, Kingdom of Saudi Arabia

    USGS Publications Warehouse

    Zablocki, Charles J.; Hajnour, M.O.

    1987-01-01

    Telluric-electric and auto-magnetotelluric measurements obtained in and around the Raha fault zone in the Buqaya area indicate that it dips steeply to the southwest. Large contrasts in the electrical properties of Qarnayn and Maraghan metasedimentary rocks located on either side of the fault are characteristic of the rocks within the fault zone. However, no large electrical contrasts were detected along several segments of a southern branch of the main fault in the Shiaila area, indicating that the rocks on either side of the fault are of similar composition. Extremely low resistivity readings in the Buqaya and Shiaila areas are associated with fracturing and clay-bearing gouge that accompany known shear zones. The locations of several shallow plutons have been inferred from these studies, one of which is probably a source of gold-bearing quartz veins in the metasedimentary rocks of the Shiaila area.

  5. A modified anomaly detection method for capsule endoscopy images using non-linear color conversion and Higher-order Local Auto-Correlation (HLAC).

    PubMed

    Hu, Erzhong; Nosato, Hirokazu; Sakanashi, Hidenori; Murakawa, Masahiro

    2013-01-01

    Capsule endoscopy is a patient-friendly endoscopy broadly utilized in gastrointestinal examination. However, the efficacy of diagnosis is restricted by the large quantity of images. This paper presents a modified anomaly detection method, by which both known and unknown anomalies in capsule endoscopy images of small intestine are expected to be detected. To achieve this goal, this paper introduces feature extraction using a non-linear color conversion and Higher-order Local Auto Correlation (HLAC) Features, and makes use of image partition and subspace method for anomaly detection. Experiments are implemented among several major anomalies with combinations of proposed techniques. As the result, the proposed method achieved 91.7% and 100% detection accuracy for swelling and bleeding respectively, so that the effectiveness of proposed method is demonstrated.

  6. Evaluation of movement restriction zone sizes in controlling classical swine fever outbreaks

    USDA-ARS?s Scientific Manuscript database

    The objective of this study was to compare the movement restriction zone sizes of 3-km, 5-km, 9-km, and 11-km with that of 7-km in controlling a classical swine fever (CSF) outbreak. Three assumptions of compliance level were considered: baseline, baseline ±10%, and baseline ±15%. The compliance lev...

  7. Time-alternating method based on single-sideband holography with half-zone-plate processing for the enlargement of viewing zones.

    PubMed

    Mishina, T; Okano, F; Yuyama, I

    1999-06-10

    The single-sideband method of holography, as is well known, cuts off beams that come from conjugate images for holograms produced in the Fraunhofer region and from objects with no phase components. The single-sideband method with half-zone-plate processing is also effective in the Fresnel region for beams from an object that has phase components. However, this method restricts the viewing zone to a narrow range. We propose a method to improve this restriction by time-alternating switching of hologram patterns and a spatial filter set on the focal plane of a reconstruction lens.

  8. Detection of combustion start in the controlled auto ignition engine by wavelet transform of the engine block vibration signal

    NASA Astrophysics Data System (ADS)

    Kim, Seonguk; Min, Kyoungdoug

    2008-08-01

    The CAI (controlled auto ignition) engine ignites fuel and air mixture by trapping high temperature burnt gas using a negative valve overlap. Due to auto ignition in CAI combustion, efficiency improvements and low level NOx emission can be obtained. Meanwhile, the CAI combustion regime is restricted and control parameters are limited. The start of combustion data in the compressed ignition engine are most critical for controlling the overall combustion. In this research, the engine block vibration signal is transformed by the Meyer wavelet to analyze CAI combustion more easily and accurately. Signal acquisition of the engine block vibration is a more suitable method for practical use than measurement of in-cylinder pressure. A new method for detecting combustion start in CAI engines through wavelet transformation of the engine block vibration signal was developed and results indicate that it is accurate enough to analyze the start of combustion. Experimental results show that wavelet transformation of engine block vibration can track the start of combustion in each cycle. From this newly developed method, the start of combustion data in CAI engines can be detected more easily and used as input data for controlling CAI combustion.

  9. 33 CFR 334.1230 - Port Orchard; naval restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Port Orchard; naval restricted... ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1230 Port Orchard; naval restricted area. (a) Port Orchard; naval restricted area—(1) The area. Shoreward of a line beginning at a...

  10. 33 CFR 334.1230 - Port Orchard; naval restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Port Orchard; naval restricted... ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1230 Port Orchard; naval restricted area. (a) Port Orchard; naval restricted area—(1) The area. Shoreward of a line beginning at a...

  11. 27 CFR 44.196a - To a foreign-trade zone.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true To a foreign-trade zone. 44... foreign-trade zone. Where tobacco products, and cigarette papers and tubes are removed from a factory or an export warehouse for delivery to a foreign-trade zone, under zone restricted status for the...

  12. 75 FR 33741 - Safety Zone; Tracey/Thompson Wedding, Lake Erie, Catawba Island, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-15

    ...-AA00 Safety Zone; Tracey/Thompson Wedding, Lake Erie, Catawba Island, OH AGENCY: Coast Guard, DHS... zone on Lake Erie, Catawba Island, Ohio. This temporary safety zone is intended to restrict vessels from portions of Lake Erie during the Tracey/Thompson Wedding Fireworks. This temporary safety zone is...

  13. KINKFOLD—an AutoLISP program for construction of geological cross-sections using borehole image data

    NASA Astrophysics Data System (ADS)

    Özkaya, Sait Ismail

    2002-04-01

    KINKFOLD is an AutoLISP program designed to construct geological cross-sections from borehole image or dip meter logs. The program uses the kink-fold method for cross-section construction. Beds are folded around hinge lines as angle bisectors so that bedding thickness remains unchanged. KINKFOLD may be used to model a wide variety of parallel fold structures, including overturned and faulted folds, and folds truncated by unconformities. The program accepts data from vertical or inclined boreholes. The KINKFOLD program cannot be used to model fault drag, growth folds, inversion structures or disharmonic folds where the bed thickness changes either because of deformation or deposition. Faulted structures and similar folds can be modelled by KINKFOLD by omitting dip measurements within fault drag zones and near axial planes of similar folds.

  14. Potential interventions by government and industry to minimize violations of temporary flight restrictions

    DOT National Transportation Integrated Search

    2005-09-30

    This document enumerates interventions to reduce the frequency of restricted airspace violations, particularly those associated with temporary flight restrictions (TFRs) and air defense identification zones (ADIZs), by more effectively providing pilo...

  15. 46 CFR 76.33-5 - Zoning.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS FIRE PROTECTION EQUIPMENT Smoke Detecting System, Details § 76.33-5 Zoning. (a) The smoke detecting system shall be divided into separate zones to restrict the area covered by any particular alarm signal. (b) The smoke detecting zone shall not include...

  16. 46 CFR 76.33-5 - Zoning.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS FIRE PROTECTION EQUIPMENT Smoke Detecting System, Details § 76.33-5 Zoning. (a) The smoke detecting system shall be divided into separate zones to restrict the area covered by any particular alarm signal. (b) The smoke detecting zone shall not include...

  17. 46 CFR 76.33-5 - Zoning.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS FIRE PROTECTION EQUIPMENT Smoke Detecting System, Details § 76.33-5 Zoning. (a) The smoke detecting system shall be divided into separate zones to restrict the area covered by any particular alarm signal. (b) The smoke detecting zone shall not include...

  18. 9 CFR 94.24 - Restrictions on the importation of pork, pork products, and swine from the APHIS-defined EU CSF...

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the zone as a restricted zone is removed by the competent veterinary authority of the Member State or... removed by the competent veterinary authority of the Member State. (2) The pork and pork products must not... issued by an official of the competent veterinary authority of the APHIS-defined EU CSF region Member...

  19. 9 CFR 94.24 - Restrictions on the importation of pork, pork products, and swine from the APHIS-defined EU CSF...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the zone as a restricted zone is removed by the competent veterinary authority of the Member State or... removed by the competent veterinary authority of the Member State. (2) The pork and pork products must not... issued by an official of the competent veterinary authority of the APHIS-defined EU CSF region Member...

  20. [Value of positive auto controls in the gel centrifugation method].

    PubMed

    Eichler, H; Kretschmer, V

    1994-01-01

    We studied 97 samples of patients being positive in the autocontrol of the indirect antiglobulin test (IAT) in the gel system (DiaMed). In 83.2%, retesting with monospecific anti-IgG serum gave also positive results, due to a specific phenomenon caused, for example, by drug-specific antibodies (AB), warm auto-AB or allo-AB. In contrast, only 52.9% of the samples retested by the standard tube technique with polyspecific antiglobulin serum reacted positive. Only in 6 patients slightly increased cold agglutinins could be detected. None of the investigated patients showed any clinical or laboratory signs of hemolysis except one with pernicious anemia. We conclude that positive results of the autocontrol in the gel IAT should be confirmed by an additional DAT in the tube technique. If this second test shows a negative result, transfusions can take place without any restrictions.

  1. Influences of Duration of Inspiratory Effort, Respiratory Mechanics, and Ventilator Type on Asynchrony With Pressure Support and Proportional Assist Ventilation.

    PubMed

    Vasconcelos, Renata S; Sales, Raquel P; Melo, Luíz H de P; Marinho, Liégina S; Bastos, Vasco Pd; Nogueira, Andréa da Nc; Ferreira, Juliana C; Holanda, Marcelo A

    2017-05-01

    Pressure support ventilation (PSV) is often associated with patient-ventilator asynchrony. Proportional assist ventilation (PAV) offers inspiratory assistance proportional to patient effort, minimizing patient-ventilator asynchrony. The objective of this study was to evaluate the influence of respiratory mechanics and patient effort on patient-ventilator asynchrony during PSV and PAV plus (PAV+). We used a mechanical lung simulator and studied 3 respiratory mechanics profiles (normal, obstructive, and restrictive), with variations in the duration of inspiratory effort: 0.5, 1.0, 1.5, and 2.0 s. The Auto-Trak system was studied in ventilators when available. Outcome measures included inspiratory trigger delay, expiratory trigger asynchrony, and tidal volume (V T ). Inspiratory trigger delay was greater in the obstructive respiratory mechanics profile and greatest with a effort of 2.0 s (160 ms); cycling asynchrony, particularly delayed cycling, was common in the obstructive profile, whereas the restrictive profile was associated with premature cycling. In comparison with PSV, PAV+ improved patient-ventilator synchrony, with a shorter triggering delay (28 ms vs 116 ms) and no cycling asynchrony in the restrictive profile. V T was lower with PAV+ than with PSV (630 mL vs 837 mL), as it was with the single-limb circuit ventilator (570 mL vs 837 mL). PAV+ mode was associated with longer cycling delays than were the other ventilation modes, especially for the obstructive profile and higher effort values. Auto-Trak eliminated automatic triggering. Mechanical ventilation asynchrony was influenced by effort, respiratory mechanics, ventilator type, and ventilation mode. In PSV mode, delayed cycling was associated with shorter effort in obstructive respiratory mechanics profiles, whereas premature cycling was more common with longer effort and a restrictive profile. PAV+ prevented premature cycling but not delayed cycling, especially in obstructive respiratory mechanics profiles, and it was associated with a lower V T . Copyright © 2017 by Daedalus Enterprises.

  2. 78 FR 30765 - Safety Zone; Bay Village Independence Day Fireworks, Lake Erie, Bay Village, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-23

    ...-AA00 Safety Zone; Bay Village Independence Day Fireworks, Lake Erie, Bay Village, OH AGENCY: Coast... zone on Lake Erie, Bay Village, OH. This safety zone is intended to restrict vessels from a portion of Lake Erie during the Bay Village Independence Day Fireworks display. This temporary safety zone is...

  3. 77 FR 39420 - Safety Zone; Bay Village Independence Day Fireworks, Lake Erie, Bay Village, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ...-AA00 Safety Zone; Bay Village Independence Day Fireworks, Lake Erie, Bay Village, OH AGENCY: Coast... zone on Lake Erie, Bay Village, OH. This safety zone is intended to restrict vessels from a portion of Lake Erie during the Bay Village Independence Day Fireworks display. This temporary safety zone is...

  4. 27 CFR 44.207a - To a foreign-trade zone.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true To a foreign-trade zone. 44....207a To a foreign-trade zone. Where tobacco products, and cigarette papers and tubes are removed from a factory or an export warehouse for delivery to a foreign-trade zone, under zone restricted status for the...

  5. 27 CFR 44.196a - To a foreign-trade zone.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false To a foreign-trade zone... Shipment § 44.196a To a foreign-trade zone. Where tobacco products, and cigarette papers and tubes are removed from a factory or an export warehouse for delivery to a foreign-trade zone, under zone restricted...

  6. 27 CFR 44.196a - To a foreign-trade zone.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2013-04-01 2013-04-01 false To a foreign-trade zone... Shipment § 44.196a To a foreign-trade zone. Where tobacco products, and cigarette papers and tubes are removed from a factory or an export warehouse for delivery to a foreign-trade zone, under zone restricted...

  7. 27 CFR 44.196a - To a foreign-trade zone.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false To a foreign-trade zone... Shipment § 44.196a To a foreign-trade zone. Where tobacco products, and cigarette papers and tubes are removed from a factory or an export warehouse for delivery to a foreign-trade zone, under zone restricted...

  8. 27 CFR 44.196a - To a foreign-trade zone.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2011-04-01 2011-04-01 false To a foreign-trade zone... Shipment § 44.196a To a foreign-trade zone. Where tobacco products, and cigarette papers and tubes are removed from a factory or an export warehouse for delivery to a foreign-trade zone, under zone restricted...

  9. 75 FR 34932 - Safety Zone; Michigan City Super Boat Grand Prix, Lake Michigan, Michigan City, IN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ...-AA00 Safety Zone; Michigan City Super Boat Grand Prix, Lake Michigan, Michigan City, IN AGENCY: Coast... zone on Lake Michigan near Michigan City, Indiana. This zone is intended to restrict vessels from a... of proposed rulemaking (NPRM) entitled Safety Zone; Michigan City Super Boat Grand Prix, Lake...

  10. 33 CFR 334.1060 - Oakland Outer Harbor adjacent to the Oakland Army Base; restricted area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the Oakland Army Base; restricted area. 334.1060 Section 334.1060 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1060 Oakland Outer Harbor adjacent to the Oakland Army Base; restricted area. (a) The area...

  11. 33 CFR 334.1320 - Kuluk Bay, Adak, Alaska; naval restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... restricted area. 334.1320 Section 334.1320 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1320 Kuluk Bay, Adak, Alaska; naval restricted area. (a) The area. The northwest portion of Kuluk Bay bounded as follows...

  12. 33 CFR 334.1320 - Kuluk Bay, Adak, Alaska; naval restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... restricted area. 334.1320 Section 334.1320 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1320 Kuluk Bay, Adak, Alaska; naval restricted area. (a) The area. The northwest portion of Kuluk Bay bounded as follows...

  13. 33 CFR 334.1060 - Oakland Outer Harbor adjacent to the Oakland Army Base; restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the Oakland Army Base; restricted area. 334.1060 Section 334.1060 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1060 Oakland Outer Harbor adjacent to the Oakland Army Base; restricted area. (a) The area...

  14. 33 CFR 334.1320 - Kuluk Bay, Adak, Alaska; naval restricted area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... restricted area. 334.1320 Section 334.1320 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1320 Kuluk Bay, Adak, Alaska; naval restricted area. (a) The area. The northwest portion of Kuluk Bay bounded as follows...

  15. 33 CFR 334.1320 - Kuluk Bay, Adak, Alaska; naval restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... restricted area. 334.1320 Section 334.1320 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1320 Kuluk Bay, Adak, Alaska; naval restricted area. (a) The area. The northwest portion of Kuluk Bay bounded as follows...

  16. 33 CFR 334.1060 - Oakland Outer Harbor adjacent to the Oakland Army Base; restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the Oakland Army Base; restricted area. 334.1060 Section 334.1060 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1060 Oakland Outer Harbor adjacent to the Oakland Army Base; restricted area. (a) The area...

  17. 33 CFR 334.1320 - Kuluk Bay, Adak, Alaska; naval restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... restricted area. 334.1320 Section 334.1320 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1320 Kuluk Bay, Adak, Alaska; naval restricted area. (a) The area. The northwest portion of Kuluk Bay bounded as follows...

  18. Automatic Generation of Algorithms for the Statistical Analysis of Planetary Nebulae Images

    NASA Technical Reports Server (NTRS)

    Fischer, Bernd

    2004-01-01

    Analyzing data sets collected in experiments or by observations is a Core scientific activity. Typically, experimentd and observational data are &aught with uncertainty, and the analysis is based on a statistical model of the conjectured underlying processes, The large data volumes collected by modern instruments make computer support indispensible for this. Consequently, scientists spend significant amounts of their time with the development and refinement of the data analysis programs. AutoBayes [GF+02, FS03] is a fully automatic synthesis system for generating statistical data analysis programs. Externally, it looks like a compiler: it takes an abstract problem specification and translates it into executable code. Its input is a concise description of a data analysis problem in the form of a statistical model as shown in Figure 1; its output is optimized and fully documented C/C++ code which can be linked dynamically into the Matlab and Octave environments. Internally, however, it is quite different: AutoBayes derives a customized algorithm implementing the given model using a schema-based process, and then further refines and optimizes the algorithm into code. A schema is a parameterized code template with associated semantic constraints which define and restrict the template s applicability. The schema parameters are instantiated in a problem-specific way during synthesis as AutoBayes checks the constraints against the original model or, recursively, against emerging sub-problems. AutoBayes schema library contains problem decomposition operators (which are justified by theorems in a formal logic in the domain of Bayesian networks) as well as machine learning algorithms (e.g., EM, k-Means) and nu- meric optimization methods (e.g., Nelder-Mead simplex, conjugate gradient). AutoBayes augments this schema-based approach by symbolic computation to derive closed-form solutions whenever possible. This is a major advantage over other statistical data analysis systems which use numerical approximations even in cases where closed-form solutions exist. AutoBayes is implemented in Prolog and comprises approximately 75.000 lines of code. In this paper, we take one typical scientific data analysis problem-analyzing planetary nebulae images taken by the Hubble Space Telescope-and show how AutoBayes can be used to automate the implementation of the necessary anal- ysis programs. We initially follow the analysis described by Knuth and Hajian [KHO2] and use AutoBayes to derive code for the published models. We show the details of the code derivation process, including the symbolic computations and automatic integration of library procedures, and compare the results of the automatically generated and manually implemented code. We then go beyond the original analysis and use AutoBayes to derive code for a simple image segmentation procedure based on a mixture model which can be used to automate a manual preproceesing step. Finally, we combine the original approach with the simple segmentation which yields a more detailed analysis. This also demonstrates that AutoBayes makes it easy to combine different aspects of data analysis.

  19. 76 FR 30018 - Safety Zone; Marysville Days Fireworks, St. Clair River, Marysville, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ...-AA00 Safety Zone; Marysville Days Fireworks, St. Clair River, Marysville, MI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on St. Clair River, Marysville, MI. This zone is intended to restrict vessels from a portion of St. Clair River...

  20. 77 FR 29901 - Safety Zone; Marysville Days Fireworks, St. Clair River, Marysville, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ...-AA00 Safety Zone; Marysville Days Fireworks, St. Clair River, Marysville, MI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on the St. Clair River, Marysville, Michigan. This zone is intended to restrict vessels from a portion of the St...

  1. 33 CFR 334.70 - Buzzards Bay, and adjacent waters, Mass.; danger zones for naval operations.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., Mass.; danger zones for naval operations. 334.70 Section 334.70 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.70 Buzzards Bay, and adjacent waters, Mass.; danger zones for naval operations. (a) Atlantic...

  2. 33 CFR 334.70 - Buzzards Bay, and adjacent waters, Mass.; danger zones for naval operations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Mass.; danger zones for naval operations. 334.70 Section 334.70 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.70 Buzzards Bay, and adjacent waters, Mass.; danger zones for naval operations. (a) Atlantic...

  3. 33 CFR 334.70 - Buzzards Bay, and adjacent waters, Mass.; danger zones for naval operations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Mass.; danger zones for naval operations. 334.70 Section 334.70 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.70 Buzzards Bay, and adjacent waters, Mass.; danger zones for naval operations. (a) Atlantic...

  4. 33 CFR 334.70 - Buzzards Bay, and adjacent waters, Mass.; danger zones for naval operations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Mass.; danger zones for naval operations. 334.70 Section 334.70 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.70 Buzzards Bay, and adjacent waters, Mass.; danger zones for naval operations. (a) Atlantic...

  5. 78 FR 45059 - Safety Zone; Sherman Private Party Fireworks, Lake Michigan, Winnetka, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ...-AA00 Safety Zone; Sherman Private Party Fireworks, Lake Michigan, Winnetka, IL AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on Lake Michigan near Winnetka, IL. This safety zone is intended to restrict vessels from a portion of Lake...

  6. 77 FR 41686 - Safety Zone; Sheffield Lake Fireworks, Lake Erie, Sheffield Lake, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-16

    ...-AA00 Safety Zone; Sheffield Lake Fireworks, Lake Erie, Sheffield Lake, OH AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on Lake Erie, Sheffield Lake, OH. This safety zone is intended to restrict vessels from a portion of Lake Erie...

  7. 78 FR 21260 - Safety Zone; Lubbers Cup Regatta; Spring Lake, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-10

    ...-AA00 Safety Zone; Lubbers Cup Regatta; Spring Lake, MI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on Spring Lake in Spring Lake, Michigan. This safety zone is intended to restrict vessels from a portion of Spring Lake due to...

  8. Health Hazard Evaluation Report HETA 85-165-1605, St. Louis Police Auto Body Shop, St. Louis, Missouri

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Carson, G.A.

    1985-07-01

    Environmental and breathing-zone samples were analyzed for toluene, lead, and total dust at the Saint Louis Police Auto Body Shop, Saint Louis, Missouri in January and February, 1985. The evaluation was requested by the Health Commissioner of the City of Saint Louis to investigate working conditions in the body shop. A prior health department investigation had indicated that there might be health hazards in the shop area. The author concludes that a potential health hazard exists due to overexposure to total dust while performing certain repairs at the facility. Recommendations include installing a supply air ventilation system for the exhaustmore » fans, orienting vehicles in the shop so that technicians are always working upstream of the airflow, and providing respiratory protection when it is not possible to control dust emissions.« less

  9. Large signal-to-noise ratio quantification in MLE for ARARMAX models

    NASA Astrophysics Data System (ADS)

    Zou, Yiqun; Tang, Xiafei

    2014-06-01

    It has been shown that closed-loop linear system identification by indirect method can be generally transferred to open-loop ARARMAX (AutoRegressive AutoRegressive Moving Average with eXogenous input) estimation. For such models, the gradient-related optimisation with large enough signal-to-noise ratio (SNR) can avoid the potential local convergence in maximum likelihood estimation. To ease the application of this condition, the threshold SNR needs to be quantified. In this paper, we build the amplitude coefficient which is an equivalence to the SNR and prove the finiteness of the threshold amplitude coefficient within the stability region. The quantification of threshold is achieved by the minimisation of an elaborately designed multi-variable cost function which unifies all the restrictions on the amplitude coefficient. The corresponding algorithm based on two sets of physically realisable system input-output data details the minimisation and also points out how to use the gradient-related method to estimate ARARMAX parameters when local minimum is present as the SNR is small. Then, the algorithm is tested on a theoretical AutoRegressive Moving Average with eXogenous input model for the derivation of the threshold and a gas turbine engine real system for model identification, respectively. Finally, the graphical validation of threshold on a two-dimensional plot is discussed.

  10. 33 CFR 334.782 - SUPSHIP Bath Maine Detachment Mobile at AUSTAL, USA, Mobile, AL; restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... warranted access into the restricted navigation area be needed, all entities are to contact the Supervisor... Mobile at AUSTAL, USA, Mobile, AL; restricted area. 334.782 Section 334.782 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA...

  11. Innovative zoning to support equine influenza eradication from New South Wales, Australia.

    PubMed

    Scott-Orr, H

    2011-07-01

    Following detection of equine influenza (EI) in New South Wales, a complete standstill was imposed the next morning on the movement of all horses and donkeys within the state. Premises' biosecurity guidelines became progressively more stringent with time in an effort to stop local spread. The standstill was highly effective as a primary response to stop EI becoming widespread across Australia, but did not prevent spread to properties contiguous to infected premises in areas of high horse density and small property size, nor transmission by fomites nor possible local airborne transmission. Within 2 weeks of the start of the outbreak, a zoning system of Purple (Special Restricted), Red (Restricted), Amber (Control), and Green (Protected) Zones was implemented, and progressively modified as disease distribution changed. The colour coding system proved to be an easy way to communicate zone changes, the approximate level of disease risk and the stringency of movement restrictions to the general public and should be adopted more generally in AUSVETPLAN. © 2011 The Author. Australian Veterinary Journal © 2011 Australian Veterinary Association.

  12. Violations of Temporary Flight Restrictions and Air Defense Identification Zones: An Analysis of Airspace Violations and Pilot Report Data

    NASA Technical Reports Server (NTRS)

    Zuschlag, Michael

    2005-01-01

    This document provides the results from a study into the apparent factors and causes of violations of restricted airspace, particularly temporary flight restrictions (TFRs) and air defense identification zones (ADIZs). By illuminating the reasons for these violations, this study aims to take the first step towards reducing them. The study assesses the basic characteristics of restricted airspace violations as well as the probable causes and factors contributing to violations. Results from the study imply most violations occur where the restriction has been in place for a significant amount of time prior to the violation. Additionally, the study results imply most violations are not due to the pilot simply being unaware of the airspace at the time of violation. In most violations, pilots are aware of the presence of the restricted airspace but have incorrect information about it, namely, its exact boundaries or procedures for authorized penetration. These results imply that the best means to reduce violations of restricted airspace is to improve the effectiveness of providing pilots the details required to avoid the airspace.

  13. 77 FR 38490 - Safety Zone; Mentor Harbor Yachting Club Fireworks, Lake Erie, Mentor, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-28

    ...-AA00 Safety Zone; Mentor Harbor Yachting Club Fireworks, Lake Erie, Mentor, OH AGENCY: Coast Guard, DHS... Erie, Mentor, OH. This safety zone is intended to restrict vessels from a portion of Lake Erie during the Mentor Harbor Yachting Club fireworks display. This temporary safety zone is necessary to protect...

  14. 76 FR 58110 - Safety Zone; Giannangeli Wedding Fireworks, Lake St. Clair, Harrison Township, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-20

    ...-AA00 Safety Zone; Giannangeli Wedding Fireworks, Lake St. Clair, Harrison Township, MI AGENCY: Coast... zone on Lake St. Clair, Harrison Township, MI. This zone is intended to restrict vessels from a portion of Lake St. Clair during the Giannangeli Wedding Fireworks. DATES: This rule is effective and will be...

  15. 77 FR 38488 - Safety Zone; Alexandria Bay Chamber of Commerce, St. Lawrence River, Alexandria Bay, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-28

    ... 1625-AA00 Safety Zone; Alexandria Bay Chamber of Commerce, St. Lawrence River, Alexandria Bay, NY... temporary safety zone on the St. Lawrence River, Alexandria Bay, New York. This safety zone is intended to restrict vessels from a portion of the St. Lawrence River during the Alexandria Bay Chamber of Commerce...

  16. 78 FR 36662 - Safety Zone; Fairport Harbor Mardi Gras, Lake Erie, Fairport, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ...-AA00 Safety Zone; Fairport Harbor Mardi Gras, Lake Erie, Fairport, OH AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on Lake Erie, Fairport Harbor, OH. This safety zone is intended to restrict vessels from a portion of Lake Erie during...

  17. 77 FR 39638 - Safety Zone; Barbara Harder Wedding Fireworks, Lake Erie, Lake View, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ...-AA00 Safety Zone; Barbara Harder Wedding Fireworks, Lake Erie, Lake View, NY AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on Lake Erie, Lake View, NY. This safety zone is intended to restrict vessels from a portion of Lake Erie...

  18. 75 FR 22333 - Safety Zone; Michigan City Super Boat Grand Prix, Lake Michigan, Michigan City, IN

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ...-AA00 Safety Zone; Michigan City Super Boat Grand Prix, Lake Michigan, Michigan City, IN AGENCY: Coast... temporary safety zone on Lake Michigan near Michigan City, Indiana. This zone is intended to restrict... ensure the safety of vessels from the hazards associated with the Michigan City Super Boat Grand Prix...

  19. 33 CFR 334.3 - Special policies.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Food fishing industry. The authority to prescribe danger zone and restricted area regulations must be exercised so as not to unreasonably interfere with or restrict the food fishing industry. Whenever the...

  20. 33 CFR 334.500 - St. Johns River, Atlantic Ocean, Sherman Creek; restricted areas and danger zone, Naval Station...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false St. Johns River, Atlantic Ocean... AND RESTRICTED AREA REGULATIONS § 334.500 St. Johns River, Atlantic Ocean, Sherman Creek; restricted... area and the Atlantic Ocean restricted area described in paragraphs (a)(2) and (a)(3) of this section...

  1. 33 CFR 334.500 - St. Johns River, Atlantic Ocean, Sherman Creek; restricted areas and danger zone, Naval Station...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false St. Johns River, Atlantic Ocean... AND RESTRICTED AREA REGULATIONS § 334.500 St. Johns River, Atlantic Ocean, Sherman Creek; restricted... area and the Atlantic Ocean restricted area described in paragraphs (a)(2) and (a)(3) of this section...

  2. 33 CFR 334.500 - St. Johns River, Atlantic Ocean, Sherman Creek; restricted areas and danger zone, Naval Station...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false St. Johns River, Atlantic Ocean... AND RESTRICTED AREA REGULATIONS § 334.500 St. Johns River, Atlantic Ocean, Sherman Creek; restricted... area and the Atlantic Ocean restricted area described in paragraphs (a)(2) and (a)(3) of this section...

  3. 76 FR 36080 - Proposed Information Collection; Comment Request; Foreign-Trade Zone Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ..., and economic impact. Manufacturing activity in zones and subzones can involve issues related to... customs-tariff related savings that result from zone procedures and the economic consequences of... its economic effects because the Act and Regulations authorize the Board to restrict or prohibit...

  4. 24 CFR 242.78 - Zoning, deed, and building restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Zoning, deed, and building... AUTHORITIES MORTGAGE INSURANCE FOR HOSPITALS Miscellaneous Requirements § 242.78 Zoning, deed, and building... to the project site, and shall comply with all applicable building and other governmental codes...

  5. 40 CFR 258.14 - Seismic impact zones.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Seismic impact zones. 258.14 Section 258.14 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Location Restrictions § 258.14 Seismic impact zones. (a) New MSWLF units and...

  6. 40 CFR 258.14 - Seismic impact zones.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 25 2011-07-01 2011-07-01 false Seismic impact zones. 258.14 Section 258.14 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR MUNICIPAL SOLID WASTE LANDFILLS Location Restrictions § 258.14 Seismic impact zones. (a) New MSWLF units and...

  7. 76 FR 55908 - Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... of an exemption to the land disposal restrictions, under the 1984 Hazardous and Solid Waste... Waste Injection Restrictions; Petition for Exemption--Class I Hazardous Waste Injection; Great Lakes... from the injection zone for as long as the waste remains hazardous. This final decision allows the...

  8. 78 FR 23246 - Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... exemption to the land disposal Restrictions, under the 1984 Hazardous and Solid Waste [[Page 23247... Waste Injection Restrictions; Petition for Exemption--Class I Hazardous Waste Injection; BASF... from the injection zone for as long as the waste remains hazardous. This final decision allows the...

  9. 77 FR 26755 - Underground Injection Control Program; Hazardous Waste Injection Restrictions; Petition for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... reissuance of an exemption to the land disposal Restrictions, under the 1984 Hazardous and Solid Waste... Waste Injection Restrictions; Petition for Exemption--Class I Hazardous Waste Injection; Diamond... from the injection zone for as long as the waste remains hazardous. This final decision allows the...

  10. A SHALLOW WATER ISOBARIC BUOY.

    DTIC Science & Technology

    The genesis, development, and testing of an instrument for following currents in shallow waters is described. The volume of the ’shallow water ...isobaric buoy’ (SWIB) varies in response to pressure signals derived from the depth of the water in which the instrument floats. Mechanisms for auto...indicate the feasibility of the system. The instrument can hover in a relatively restricted horizontal layer. The instrument may find application as a water stability indicator as well as a shallow water current tag. (Author)

  11. Rolling element bearing fault diagnosis based on Over-Complete rational dilation wavelet transform and auto-correlation of analytic energy operator

    NASA Astrophysics Data System (ADS)

    Singh, Jaskaran; Darpe, A. K.; Singh, S. P.

    2018-02-01

    Local damage in rolling element bearings usually generates periodic impulses in vibration signals. The severity, repetition frequency and the fault excited resonance zone by these impulses are the key indicators for diagnosing bearing faults. In this paper, a methodology based on over complete rational dilation wavelet transform (ORDWT) is proposed, as it enjoys a good shift invariance. ORDWT offers flexibility in partitioning the frequency spectrum to generate a number of subbands (filters) with diverse bandwidths. The selection of the optimal filter that perfectly overlaps with the bearing fault excited resonance zone is based on the maximization of a proposed impulse detection measure "Temporal energy operated auto correlated kurtosis". The proposed indicator is robust and consistent in evaluating the impulsiveness of fault signals in presence of interfering vibration such as heavy background noise or sporadic shocks unrelated to the fault or normal operation. The structure of the proposed indicator enables it to be sensitive to fault severity. For enhanced fault classification, an autocorrelation of the energy time series of the signal filtered through the optimal subband is proposed. The application of the proposed methodology is validated on simulated and experimental data. The study shows that the performance of the proposed technique is more robust and consistent in comparison to the original fast kurtogram and wavelet kurtogram.

  12. 76 FR 43896 - Safety Zone; Kathleen Whelan Wedding Fireworks, Lake St. Clair, Grosse Pointe Farms, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-22

    ...-AA00 Safety Zone; Kathleen Whelan Wedding Fireworks, Lake St. Clair, Grosse Pointe Farms, MI AGENCY... safety zone on Lake St. Clair, Grosse Pointe Farms, MI. This zone is intended to restrict vessels from a portion of Lake St. Clair during the Kathleen Whelan Wedding Fireworks. DATES: This rule is effective from...

  13. 76 FR 21637 - Safety Zone; Ford Estate Wedding Fireworks, Lake St. Clair, Grosse Pointe Shores, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-18

    ...-AA00 Safety Zone; Ford Estate Wedding Fireworks, Lake St. Clair, Grosse Pointe Shores, MI AGENCY: Coast... zone on Lake St. Clair, Grosse Pointe Shores, MI. This zone is intended to restrict vessels from a portion of Lake St. Clair River during the Ford Estate Wedding Fireworks. DATES: This rule is effective...

  14. 77 FR 49351 - Safety Zone; Port Huron Float-Down, St. Clair River, Port Huron, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-16

    ...-AA00 Safety Zone; Port Huron Float-Down, St. Clair River, Port Huron, MI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on the St. Clair River, Port Huron, MI. This zone is intended to restrict vessels from a portion of the St. Clair...

  15. 33 CFR 165.768 - Security Zone; MacDill Air Force Base, Tampa Bay, FL.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Security Zone; MacDill Air Force....768 Security Zone; MacDill Air Force Base, Tampa Bay, FL. (a) Location. The following area is a security zone which exists concurrent with an Army Corps of Engineers restricted area in § 334.635 of this...

  16. 33 CFR 165.768 - Security Zone; MacDill Air Force Base, Tampa Bay, FL.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Security Zone; MacDill Air Force....768 Security Zone; MacDill Air Force Base, Tampa Bay, FL. (a) Location. The following area is a security zone which exists concurrent with an Army Corps of Engineers restricted area in § 334.635 of this...

  17. 33 CFR 165.768 - Security Zone; MacDill Air Force Base, Tampa Bay, FL.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Security Zone; MacDill Air Force....768 Security Zone; MacDill Air Force Base, Tampa Bay, FL. (a) Location. The following area is a security zone which exists concurrent with an Army Corps of Engineers restricted area in § 334.635 of this...

  18. 33 CFR 165.768 - Security Zone; MacDill Air Force Base, Tampa Bay, FL.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Security Zone; MacDill Air Force....768 Security Zone; MacDill Air Force Base, Tampa Bay, FL. (a) Location. The following area is a security zone which exists concurrent with an Army Corps of Engineers restricted area in § 334.635 of this...

  19. 77 FR 38486 - Safety Zone; City of Tonawanda July 4th Celebration, Niagara River, Tonawanda, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-28

    ... 1625-AA00 Safety Zone; City of Tonawanda July 4th Celebration, Niagara River, Tonawanda, NY AGENCY... safety zone on the Niagara River, Tonawanda, New York. This safety zone is intended to restrict vessels from a portion of the Niagara River during the City of Tonawanda July 4th Celebration fireworks on July...

  20. 76 FR 32071 - Safety Zone; Conneaut Festival Fireworks, Conneaut Harbor, Conneaut, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-03

    ...-AA00 Safety Zone; Conneaut Festival Fireworks, Conneaut Harbor, Conneaut, OH AGENCY: Coast Guard, DHS... Conneaut Harbor, Conneaut, OH for the Conneaut Festival Fireworks. This zone is intended to restrict vessels from a portion of Conneaut Harbor, Conneaut, OH during the Conneaut Festival Fireworks on July 3...

  1. 76 FR 34865 - Safety Zone; Rochester Harbor Festival, Genesee River, Rochester, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ...-AA00 Safety Zone; Rochester Harbor Festival, Genesee River, Rochester, NY AGENCY: Coast Guard, DHS... Genesee River, Rochester, NY for the Rochester Harbor Festival fireworks. This zone is intended to restrict vessels from the mouth of the Genesee River in Rochester during the Rochester Harbor Festival...

  2. 75 FR 53870 - Security Zone, Mackinac Bridge, Straits of Mackinac, Michigan

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-02

    ... Zone, Mackinac Bridge, Straits of Mackinac, Michigan AGENCY: Coast Guard, DHS. ACTION: Notice of enforcement of regulation. SUMMARY: The Coast Guard will enforce the Mackinac Bridge Walk security zone on the... bridge. During the enforcement period, navigational and operational restrictions will be placed on all...

  3. 33 CFR 334.780 - Pensacola Bay, Fla.; seaplane restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.780 Pensacola Bay... (sailing, motorized, and/or rowed or self-propelled), private and commercial fishing vessels, other...

  4. 33 CFR 334.780 - Pensacola Bay, Fla.; seaplane restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.780 Pensacola Bay... (sailing, motorized, and/or rowed or self-propelled), private and commercial fishing vessels, other...

  5. 33 CFR 334.780 - Pensacola Bay, Fla.; seaplane restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.780 Pensacola Bay... (sailing, motorized, and/or rowed or self-propelled), private and commercial fishing vessels, other...

  6. Protection method for an optical information carrier

    NASA Astrophysics Data System (ADS)

    Pitsyuga, Vitaly V.; Kolesnikov, Michael Y.; Kosyak, Igor V.

    1997-02-01

    Now information protection on personal carriers (for example, cards) from an unauthorized access (UA) is a very important problem in connection with wide introduction of proper automatic systems for information processing in different spheres of human activity. These are financial, medical and information services, an access to restricted units and so on. There is proposed to use physical parameters of the special coating part (so-called restricted zone) to information protection on optical carriers (laser cards). There is formed restricted zone on the surface of the recording coating of a laser card. The unique information about every laser card to creating a protective passport from UA is obtained by readout of defects parameters.

  7. Implementation hurdles of an interactive, integrated, point-of-care computerised decision support system for hospital antibiotic prescription.

    PubMed

    Chow, A L; Ang, A; Chow, C Z; Ng, T M; Teng, C; Ling, L M; Ang, B S; Lye, D C

    2016-02-01

    Antimicrobial stewardship is used to combat antimicrobial resistance. In Singapore, a tertiary hospital has integrated a computerised decision support system, called Antibiotic Resistance Utilisation and Surveillance-Control (ARUSC), into the electronic inpatient prescribing system. ARUSC is launched either by the physician to seek guidance for an infectious disease condition or via auto-trigger when restricted antibiotics are prescribed. This paper describes the implementation of ARUSC over three phases from 1 May 2011 to 30 April 2013, compared factors between ARUSC launches via auto-trigger and for guidance, examined factors associated with acceptance of ARUSC recommendations, and assessed user acceptability. During the study period, a monthly average of 9072 antibiotic prescriptions was made, of which 2370 (26.1%) involved ARUSC launches. Launches via auto-trigger comprised 48.1% of ARUSC launches. In phase 1, 23% of ARUSC launches were completed. This rose to 38% in phase 2, then 87% in phase 3, as escapes from the ARUSC programme were sequentially disabled. Amongst completed launches for guidance, 89% of ARUSC recommendations were accepted versus 40% amongst completed launches via auto-trigger. Amongst ARUSC launches for guidance, being from a medical department [adjusted odds ratio (aOR)=1.20, 95% confidence interval (CI) 1.04-1.37] and ARUSC launch during on-call (aOR=1.81, 95% CI 1.61-2.05) were independently associated with acceptance of ARUSC recommendations. Junior physicians found ARUSC useful. Senior physicians found ARUSC reliable but admitted to having preferences for antibiotics that may conflict with ARUSC. Hospital-wide implementation of ARUSC encountered hurdles from physicians. With modifications, the completion rate improved. Copyright © 2015 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

  8. Responses of biomass briquetting and pelleting to water-involved pretreatments and subsequent enzymatic hydrolysis.

    PubMed

    Li, Yang; Li, Xiaotong; Shen, Fei; Wang, Zhanghong; Yang, Gang; Lin, Lili; Zhang, Yanzong; Zeng, Yongmei; Deng, Shihuai

    2014-01-01

    Although lignocellulosic biomass has been extensively regarded as the most important resource for bioethanol, the wide application was seriously restricted by the high transportation cost of biomass. Currently, biomass densification is regarded as an acceptable solution to this issue. Herein, briquettes, pellets and their corresponding undensified biomass were pretreated by diluted-NaOH and hydrothermal method to investigate the responses of biomass densification to these typical water-involved pretreatments and subsequent enzymatic hydrolysis. The densified biomass auto-swelling was initially investigated before pretreatment. Results indicated pellets could be totally auto-swollen in an hour, while it took about 24 h for briquettes. When diluted-NaOH pretreatment was performed, biomass briquetting and pelleting improved sugar conversion rate by 20.1% and 5.5% comparing with their corresponding undensified biomass. Pelleting improved sugar conversion rate by 7.0% after hydrothermal pretreatment comparing with the undensified biomass. However, briquetting disturbed hydrothermal pretreatment resulting in the decrease of sugar conversion rate by 15.0%. Copyright © 2013 Elsevier Ltd. All rights reserved.

  9. 33 CFR 334.1325 - United States Army Restricted Area, Kuluk Bay, Adak, Alaska.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Area, Kuluk Bay, Adak, Alaska. 334.1325 Section 334.1325 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1325 United States Army Restricted Area, Kuluk Bay, Adak, Alaska. (a) The area. The area within a...

  10. 33 CFR 334.1325 - United States Army Restricted Area, Kuluk Bay, Adak, Alaska.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Area, Kuluk Bay, Adak, Alaska. 334.1325 Section 334.1325 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1325 United States Army Restricted Area, Kuluk Bay, Adak, Alaska. (a) The area. The area within a...

  11. 33 CFR 334.1325 - United States Army Restricted Area, Kuluk Bay, Adak, Alaska.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Area, Kuluk Bay, Adak, Alaska. 334.1325 Section 334.1325 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1325 United States Army Restricted Area, Kuluk Bay, Adak, Alaska. (a) The area. The area within a...

  12. 33 CFR 334.1275 - West Arm Behm Canal, Ketchikan, Alaska, restricted areas.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false West Arm Behm Canal, Ketchikan, Alaska, restricted areas. 334.1275 Section 334.1275 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1275 West Arm...

  13. 33 CFR 334.1275 - West Arm Behm Canal, Ketchikan, Alaska, restricted areas.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false West Arm Behm Canal, Ketchikan, Alaska, restricted areas. 334.1275 Section 334.1275 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1275 West Arm...

  14. 33 CFR 334.1275 - West Arm Behm Canal, Ketchikan, Alaska, restricted areas.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false West Arm Behm Canal, Ketchikan, Alaska, restricted areas. 334.1275 Section 334.1275 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1275 West Arm...

  15. 33 CFR 334.1275 - West Arm Behm Canal, Ketchikan, Alaska, restricted areas.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false West Arm Behm Canal, Ketchikan, Alaska, restricted areas. 334.1275 Section 334.1275 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1275 West Arm...

  16. METHOD AND APPARATUS FOR PRODUCING POWER

    DOEpatents

    Wollan, E.O.

    1961-06-27

    A neutronic reactor comprising two discrete zones; namely, an inner zone containing fissionable material and an outer zone containing fertile material is described. The inner zone is operated at a low temperature and is cooled by pressurized water. The outer zone is operated at a substantially higher temperature and is cooled by steam flashed from the inner zone. The reactor is particularly advantageous in that it produces high temperature steam; yet the materials of construction in the core (inner zone) are not restricted to materials capable of withstanding high temperature operation.

  17. 75 FR 34362 - Safety Zone; Festivals & Fireworks Celebration, East Moran Bay, Lake Huron, St. Ignace, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ...-AA00 Safety Zone; Festivals & Fireworks Celebration, East Moran Bay, Lake Huron, St. Ignace, MI AGENCY... safety zone on East Moran Bay, Lake Huron, St. Ignace, MI. This zone is intended to restrict vessels from... portion of East Moran Bay, Lake Huron, St. Ignace, MI between 9 p.m. and 11 p.m. on June 26, July 10, July...

  18. 78 FR 39608 - Safety Zone; Summer in the City Water Ski Show; Fox River, Green Bay, WI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ...-AA00 Safety Zone; Summer in the City Water Ski Show; Fox River, Green Bay, WI AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on the Fox River in Green Bay, WI. This safety zone is intended to restrict vessels from a portion of the Fox River...

  19. 76 FR 52266 - Safety Zone; Coast Guard Exercise, Detroit River, Ambassador Bridge to the Western Tip of Belle Isle

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-22

    ...-AA00 Safety Zone; Coast Guard Exercise, Detroit River, Ambassador Bridge to the Western Tip of Belle... Bridge to the western tip of Belle Isle. This safety zone is intended to restrict vessels from portions.... on August 23, 2011. The safety zone will begin at Ambassador Bridge to the western tip of Belle Isle...

  20. 33 CFR 165.1110 - Security Zone: Coronado Bay Bridge, San Diego, CA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Bridge, San Diego, CA. 165.1110 Section 165.1110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT... § 165.1110 Security Zone: Coronado Bay Bridge, San Diego, CA. (a) Location. All navigable waters of San... pilings of the Coronado Bay Bridge. These security zones will not restrict the main navigational channel...

  1. 77 FR 42642 - Safety Zone; City of Ogdensburg Fireworks, St. Lawrence River, Ogdensburg, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ...-AA00 Safety Zone; City of Ogdensburg Fireworks, St. Lawrence River, Ogdensburg, NY AGENCY: Coast Guard... the St. Lawrence River, Ogdensburg, NY. This safety zone is intended to restrict vessels from a portion of the St. Lawrence River during the City of Ogdensburg Fireworks display. This temporary safety...

  2. 77 FR 62440 - Safety Zone; Wounded Warriors Benefit, Lake Erie, Huron, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    ...-AA00 Safety Zone; Wounded Warriors Benefit, Lake Erie, Huron, OH AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on the waters of Lake Erie, East Huron, Ohio. This regulation is intended to restrict vessels from portions of Lake Erie...

  3. 33 CFR 165.1110 - Security Zone: Coronado Bay Bridge, San Diego, CA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Bridge, San Diego, CA. 165.1110 Section 165.1110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT... § 165.1110 Security Zone: Coronado Bay Bridge, San Diego, CA. (a) Location. All navigable waters of San... pilings of the Coronado Bay Bridge. These security zones will not restrict the main navigational channel...

  4. Land Use Controls and the Provision of Education. NBER Working Paper No. 17730

    ERIC Educational Resources Information Center

    Hanushek, Eric A.; Yilmaz, Kuzey

    2012-01-01

    Considerable prior analysis has gone into the study of zoning restrictions on locational choice and on fiscal burdens. The prior work on zoning--particularly fiscal or exclusionary zoning--has provided both inconclusive theoretical results and quite inconsistent empirical support of the theory. More importantly, none of this work addresses…

  5. Project CHECO Southeast Asia Report. Air Operations in Northern Laos, 1 November 1970 - 1 April 1971

    DTIC Science & Technology

    1971-05-03

    to be of sufficient size and scope to warrant a significant increase in the daily tacair sortie rate provided by Seventh Air Force. The execution of...weather, however, delayed the operation. A last-minute change of HLZs was made by CAS, but weather and faulty execution precluded proper zone...Artillery Airborne Battlefield Command and Control Center Attacks by Fire Jtq 1£4+, .. Auto Defense du Choc . Technically an obsolete tenn now. Refers

  6. 33 CFR 334.570 - Banana River near Orsino, Fla.; restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Banana River near Orsino, Fla... THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.570 Banana River near Orsino, Fla.; restricted area. (a) The area. That part of Banana River N of the NASA Banana River...

  7. 33 CFR 334.570 - Banana River near Orsino, Fla.; restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Banana River near Orsino, Fla... THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.570 Banana River near Orsino, Fla.; restricted area. (a) The area. That part of Banana River N of the NASA Banana River...

  8. 33 CFR 334.570 - Banana River near Orsino, Fla.; restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Banana River near Orsino, Fla... THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.570 Banana River near Orsino, Fla.; restricted area. (a) The area. That part of Banana River N of the NASA Banana River...

  9. 33 CFR 334.570 - Banana River near Orsino, Fla.; restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Banana River near Orsino, Fla... THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.570 Banana River near Orsino, Fla.; restricted area. (a) The area. That part of Banana River N of the NASA Banana River...

  10. 33 CFR 334.570 - Banana River near Orsino, Fla.; restricted area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Banana River near Orsino, Fla... THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.570 Banana River near Orsino, Fla.; restricted area. (a) The area. That part of Banana River N of the NASA Banana River...

  11. 33 CFR 334.560 - Banana River at Patrick Air Force Base, Fla.; restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Banana River at Patrick Air Force Base, Fla.; restricted area. 334.560 Section 334.560 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.560 Banana...

  12. 33 CFR 334.1490 - Caribbean Sea, at St. Croix, V.I.; restricted areas.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Caribbean Sea, at St. Croix, V.I.; restricted areas. 334.1490 Section 334.1490 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1490 Caribbean Sea...

  13. 33 CFR 334.1490 - Caribbean Sea, at St. Croix, V.I.; restricted areas.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Caribbean Sea, at St. Croix, V.I.; restricted areas. 334.1490 Section 334.1490 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1490 Caribbean Sea...

  14. 50 CFR Table 4 to Part 679 - Steller Sea Lion Protection Areas Pollock Fisheries Restrictions

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Steller Sea Lion Protection Areas Pollock... EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt. 679, Table 4 Table 4 to Part 679—Steller Sea Lion Protection Areas Pollock Fisheries Restrictions Steller Sea Lion Protection Areas Pollock Fisheries Restrictions Column...

  15. 50 CFR Table 4 to Part 679 - Steller Sea Lion Protection Areas Pollock Fisheries Restrictions

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Steller Sea Lion Protection Areas Pollock... EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt. 679, Table 4 Table 4 to Part 679—Steller Sea Lion Protection Areas Pollock Fisheries Restrictions Steller Sea Lion Protection Areas Pollock Fisheries Restrictions Column...

  16. 50 CFR Table 4 to Part 679 - Steller Sea Lion Protection Areas Pollock Fisheries Restrictions

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Steller Sea Lion Protection Areas Pollock... EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt. 679, Table 4 Table 4 to Part 679—Steller Sea Lion Protection Areas Pollock Fisheries Restrictions Steller Sea Lion Protection Areas Pollock Fisheries Restrictions Column...

  17. 75 FR 38723 - Safety Zone; St. Ignace 4th of July Fireworks, East Moran Bay, Lake Huron, St. Ignace, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-06

    ...-AA00 Safety Zone; St. Ignace 4th of July Fireworks, East Moran Bay, Lake Huron, St. Ignace, MI AGENCY... safety zone on East Moran Bay, Lake Huron, St. Ignace, Michigan. This zone is intended to restrict vessels from a portion of East Moran Bay during the St. Ignace 4th of July Fireworks display, July 4, 2010...

  18. 78 FR 53675 - Safety Zone; Lake Erie Heritage Foundation, Battle of Lake Erie Reenactment; Lake Erie, Put-in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ...-AA00 Safety Zone; Lake Erie Heritage Foundation, Battle of Lake Erie Reenactment; Lake Erie, Put-in-Bay... temporary safety zone in the waters of Lake Erie in the vicinity of Put-In-Bay, OH. This safety zone is intended to restrict vessels from a portion of Lake Erie during Battle of Lake Erie Reenactment near Put-In...

  19. 33 CFR 334.961 - Pacific Ocean, San Clemente Island, California, naval danger zone off the northwest shore.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Pacific Ocean, San Clemente... RESTRICTED AREA REGULATIONS § 334.961 Pacific Ocean, San Clemente Island, California, naval danger zone off the northwest shore. (a) The danger zone: The waters of the Pacific Ocean adjacent to San Clemente...

  20. 33 CFR 334.961 - Pacific Ocean, San Clemente Island, California, naval danger zone off the northwest shore.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Pacific Ocean, San Clemente... RESTRICTED AREA REGULATIONS § 334.961 Pacific Ocean, San Clemente Island, California, naval danger zone off the northwest shore. (a) The danger zone: The waters of the Pacific Ocean adjacent to San Clemente...

  1. 33 CFR 334.961 - Pacific Ocean, San Clemente Island, California, naval danger zone off the northwest shore.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Pacific Ocean, San Clemente... RESTRICTED AREA REGULATIONS § 334.961 Pacific Ocean, San Clemente Island, California, naval danger zone off the northwest shore. (a) The danger zone: The waters of the Pacific Ocean adjacent to San Clemente...

  2. 33 CFR 334.961 - Pacific Ocean, San Clemente Island, California, naval danger zone off the northwest shore.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Pacific Ocean, San Clemente... RESTRICTED AREA REGULATIONS § 334.961 Pacific Ocean, San Clemente Island, California, naval danger zone off the northwest shore. (a) The danger zone: The waters of the Pacific Ocean adjacent to San Clemente...

  3. 76 FR 41691 - Safety Zone; BGSU Football Gridiron Classic Golf and Dinner Fireworks, Catawba Island Club, Port...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-15

    ...-AA00 Safety Zone; BGSU Football Gridiron Classic Golf and Dinner Fireworks, Catawba Island Club, Port.... This zone is intended to restrict vessels from portions of Lake Erie during the BGSU Football Gridiron... Purpose On July 25, 2011, Bowling Green State University will hold its BGSU Football Gridiron Classic Golf...

  4. 76 FR 27251 - Safety Zone; Coughlin Wedding Fireworks, Lake St. Clair, Harrison Township, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ...-AA00 Safety Zone; Coughlin Wedding Fireworks, Lake St. Clair, Harrison Township, MI AGENCY: Coast Guard... Lake St. Clair, Harrison Township, MI. This safety zone is intended to restrict vessels from a portion of Lake St. Clair during the Coughlin Wedding Fireworks. DATES: This rule is effective from 10 p.m...

  5. 19 CFR 146.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., privileged foreign, zone restricted, or domestic. [T.D. 86-16, 51 FR 5049, Feb. 11, 1986, as amended by T.D... (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.1 Definitions. (a) The following words, defined in section 1 of the Foreign-Trade Zones Act of 1934, as amended (19 U.S.C. 81a), are given the same meaning...

  6. 19 CFR 146.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., privileged foreign, zone restricted, or domestic. [T.D. 86-16, 51 FR 5049, Feb. 11, 1986, as amended by T.D... (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.1 Definitions. (a) The following words, defined in section 1 of the Foreign-Trade Zones Act of 1934, as amended (19 U.S.C. 81a), are given the same meaning...

  7. 19 CFR 146.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., privileged foreign, zone restricted, or domestic. [T.D. 86-16, 51 FR 5049, Feb. 11, 1986, as amended by T.D... (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.1 Definitions. (a) The following words, defined in section 1 of the Foreign-Trade Zones Act of 1934, as amended (19 U.S.C. 81a), are given the same meaning...

  8. 19 CFR 146.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., privileged foreign, zone restricted, or domestic. [T.D. 86-16, 51 FR 5049, Feb. 11, 1986, as amended by T.D... (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.1 Definitions. (a) The following words, defined in section 1 of the Foreign-Trade Zones Act of 1934, as amended (19 U.S.C. 81a), are given the same meaning...

  9. 19 CFR 146.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., privileged foreign, zone restricted, or domestic. [T.D. 86-16, 51 FR 5049, Feb. 11, 1986, as amended by T.D... (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.1 Definitions. (a) The following words, defined in section 1 of the Foreign-Trade Zones Act of 1934, as amended (19 U.S.C. 81a), are given the same meaning...

  10. 76 FR 20532 - Safety Zone; Boom Days, Niagara River, Niagara Falls, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ...-AA00 Safety Zone; Boom Days, Niagara River, Niagara Falls, NY AGENCY: Coast Guard, DHS. ACTION..., Niagara Falls, NY for the Boom Days Fireworks. This zone is intended to restrict vessels from La Salle Marina and a portion of the Niagara River, Niagara Falls, NY during the Boom Days Fireworks on April 16...

  11. 75 FR 34936 - Safety Zone; Chicago Tall Ships Fireworks, Lake Michigan, Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ...-AA00 Safety Zone; Chicago Tall Ships Fireworks, Lake Michigan, Chicago, IL AGENCY: Coast Guard, DHS... waters of Lake Michigan within Chicago Harbor, Chicago, Illinois. This zone is intended to restrict... CWO2 Jon Grob, U.S. Coast Guard, Sector Lake Michigan, telephone (414)747-7188, e-mail [email protected

  12. 33 CFR 334.961 - Pacific Ocean, San Clemente Island, California, naval danger zone off the northwest shore.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Island, California, naval danger zone off the northwest shore. 334.961 Section 334.961 Navigation and... RESTRICTED AREA REGULATIONS § 334.961 Pacific Ocean, San Clemente Island, California, naval danger zone off... regulations in this section shall be enforced by the commander, Naval Base, San Diego, California, and such...

  13. 78 FR 53677 - Safety Zone; Battle of Lake Erie Fireworks, Lake Erie, Put-In-Bay, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ...-AA00 Safety Zone; Battle of Lake Erie Fireworks, Lake Erie, Put-In- Bay, OH AGENCY: Coast Guard, DHS... waters of Lake Erie, Put-In-Bay, Ohio. This zone is intended to restrict vessels from a portion of Lake Erie during the Battle of Lake Erie Fireworks. [[Page 53678

  14. 75 FR 56467 - Safety Zone; Ocean City Beachfront Air Show, Ocean City, NJ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-16

    ...-AA00 Safety Zone; Ocean City Beachfront Air Show, Ocean City, NJ AGENCY: Coast Guard, DHS. ACTION... Atlantic Ocean, Ocean City, NJ. The temporary safety zone will restrict vessel traffic from a portion of the Atlantic Ocean during the Ocean City Beachfront Air Show, which is an aerial demonstration to be...

  15. 78 FR 18238 - Safety Zone; SFPD Training Safety Zone; San Francisco Bay, San Francisco, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... operations that require freedom of movement in a defined area. The safety zone is necessary to provide for... exercise. This restricted area is necessary to provide freedom of movement for law enforcement officers... message can be received without jeopardizing the safety or security of people, places or vessels. 7...

  16. Auto-Gopher: A Wireline Deep Sampler Driven by Piezoelectric Percussive Actuator and EM Rotary Motor

    NASA Technical Reports Server (NTRS)

    Badescu, Mircea; Ressa, Aaron; Jae Lee, Hyeong; Bar-Cohen, Yoseph; Sherrit, Stewart; Zacny, Kris; Paulsen, Gale L.; Beegle, Luther; Bao, Xiaoqi

    2013-01-01

    The ability to penetrate subsurfaces and perform sample acquisition at depth of meters may be critical for future NASA in-situ exploration missions to bodies in the solar system, including Mars and Europa. A corer/sampler was developed with the goal of enabling acquisition of samples from depths of several meters where if used on Mars would be beyond the oxidized and sterilized zone. For this purpose, we developed a rotary-hammering coring drill, called Auto-Gopher, which employs a piezoelectric actuated percussive mechanism for breaking formations and an electric motor that rotates the bit to remove the powdered cuttings. This sampler is a wireline mechanism that can be fed into and retrieved from the drilled hole using a winch and a cable. It includes an inchworm anchoring mechanism allowing the drill advancement and weight on bit control without twisting the reeling and power cables. The penetration rate is being optimized by simultaneously activating the percussive and rotary motions of the Auto-Gopher. The percussive mechanism is based on the Ultrasonic/Sonic Drill/Corer (USDC) mechanism that is driven by piezoelectric stack and that was demonstrated to require low axial preload. The design and fabrication of this device were presented in previous publications. This paper presents the results of laboratory and field tests and lessons learned from this development.

  17. Level-2 Milestone 6007: Sierra Early Delivery System Deployed to Secret Restricted Network

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bertsch, A. D.

    This report documents the delivery and installation of Shark, a CORAL Sierra early delivery system deployed on the LLNL SRD network. Early ASC program users have run codes on the machine in support of application porting for the final Sierra system which will be deployed at LLNL in CY2018. In addition to the SRD resource, Shark, unclassified resources, Rzmanta and Ray, have been deployed on the LLNL Restricted Zone and Collaboration Zone networks in support of application readiness for the Sierra platform.

  18. 32 CFR 245.31 - ESCAT test.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ESCAT testing, the responsible military commander will notify the ATCSCC using the following sample... control measures are being implemented. (Some examples are: Flight restricted zones, Temporary Flight... aircraft not previously mentioned as exemptions are restricted from flight in the affected area until...

  19. 32 CFR 245.31 - ESCAT test.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ESCAT testing, the responsible military commander will notify the ATCSCC using the following sample... control measures are being implemented. (Some examples are: Flight restricted zones, Temporary Flight... aircraft not previously mentioned as exemptions are restricted from flight in the affected area until...

  20. 32 CFR 245.31 - ESCAT test.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ESCAT testing, the responsible military commander will notify the ATCSCC using the following sample... control measures are being implemented. (Some examples are: Flight restricted zones, Temporary Flight... aircraft not previously mentioned as exemptions are restricted from flight in the affected area until...

  1. Evaluation of Movement Restriction Zone Sizes in Controlling Classical Swine Fever Outbreaks

    PubMed Central

    Yadav, Shankar; Olynk Widmar, Nicole; Lay, Donald C.; Croney, Candace; Weng, Hsin-Yi

    2017-01-01

    The objective of this study was to compare the impacts of movement restriction zone sizes of 3, 5, 9, and 11 km with that of 7 km (the recommended zone size in the United States) in controlling a classical swine fever (CSF) outbreak. In addition to zone size, different compliance assumptions and outbreak types (single site and multiple site) were incorporated in the study. Three assumptions of compliance level were simulated: baseline, baseline ± 10%, and baseline ± 15%. The compliance level was held constant across all zone sizes in the baseline simulation. In the baseline ± 10% and baseline ± 15% simulations, the compliance level was increased for 3 and 5 km and decreased for 9 and 11 km from the baseline by the indicated percentages. The compliance level remained constant in all simulations for the 7-km zone size. Four single-site (i.e., with one index premises at the onset of outbreak) and four multiple-site (i.e., with more than one index premises at the onset of outbreak) CSF outbreak scenarios in Indiana were simulated incorporating various zone sizes and compliance assumptions using a stochastic between-premises disease spread model to estimate epidemic duration, percentage of infected, and preemptively culled swine premises. Furthermore, a risk assessment model that incorporated the results from the disease spread model was developed to estimate the number of swine premises under movement restrictions that would experience animal welfare outcomes of overcrowding or feed interruption during a CSF outbreak in Indiana. Compared with the 7-km zone size, the 3-km zone size resulted in a longer median epidemic duration, larger percentages of infected premises, and preemptively culled premises (P’s < 0.001) across all compliance assumptions and outbreak types. With the assumption of a higher compliance level, the 5-km zone size significantly (P < 0.001) reduced the epidemic duration and percentage of swine premises that would experience animal welfare outcomes in both outbreak types, whereas assumption of a lower compliance level for 9- and 11-km zone sizes significantly (P < 0.001) increased the epidemic duration and percentage of swine premises with animal welfare outcomes compared with the 7-km zone size. The magnitude of impact due to a zone size varied across the outbreak types (single site and multiple site). Overall, the 7-km zone size was found to be most effective in controlling CSF outbreaks, whereas the 5-km zone size was comparable to the 7-km zone size in some circumstances. PMID:28119920

  2. The Role of Protected Areas in the Avoidance of Anthropogenic Conversion in a High Pressure Region: A Matching Method Analysis in the Core Region of the Brazilian Cerrado

    PubMed Central

    Paiva, Rodrigo José Oliveira; Brites, Ricardo Seixas; Machado, Ricardo Bomfim

    2015-01-01

    Global efforts to avoid anthropogenic conversion of natural habitat rely heavily on the establishment of protected areas. Studies that evaluate the effectiveness of these areas with a focus on preserving the natural habitat define effectiveness as a measure of the influence of protected areas on total avoided conversion. Changes in the estimated effectiveness are related to local and regional differences, evaluation methods, restriction categories that include the protected areas, and other characteristics. The overall objective of this study was to evaluate the effectiveness of protected areas to prevent the advance of the conversion of natural areas in the core region of the Brazil’s Cerrado Biome, taking into account the influence of the restriction degree, governmental sphere, time since the establishment of the protected area units, and the size of the area on the performance of protected areas. The evaluation was conducted using matching methods and took into account the following two fundamental issues: control of statistical biases caused by the influence of covariates on the likelihood of anthropogenic conversion and the non-randomness of the allocation of protected areas throughout the territory (spatial correlation effect) and the control of statistical bias caused by the influence of auto-correlation and leakage effect. Using a sample design that is not based on ways to control these biases may result in outcomes that underestimate or overestimate the effectiveness of those units. The matching method accounted for a bias reduction in 94–99% of the estimation of the average effect of protected areas on anthropogenic conversion and allowed us to obtain results with a reduced influence of the auto-correlation and leakage effects. Most protected areas had a positive influence on the maintenance of natural habitats, although wide variation in this effectiveness was dependent on the type, restriction, governmental sphere, size and age group of the unit. PMID:26222140

  3. Development of a prototype land use model for statewide transportation planning activities.

    DOT National Transportation Integrated Search

    2011-11-30

    Future land use forecasting is an important input to transportation planning modeling. Traditionally, land use is allocated to individual : traffic analysis zones (TAZ) based on variables such as the amount of vacant land, zoning restriction, land us...

  4. Sensorimotor restriction affects complex movement topography and reachable space in the rat motor cortex.

    PubMed

    Budri, Mirco; Lodi, Enrico; Franchi, Gianfranco

    2014-01-01

    Long-duration intracortical microstimulation (ICMS) studies with 500 ms of current pulses suggest that the forelimb area of the motor cortex is organized into several spatially distinct functional zones that organize movements into complex sequences. Here we studied how sensorimotor restriction modifies the extent of functional zones, complex movements, and reachable space representation in the rat forelimb M1. Sensorimotor restriction was achieved by means of whole-forelimb casting of 30 days duration. Long-duration ICMS was carried out 12 h and 14 days after cast removal. Evoked movements were measured using a high-resolution 3D optical system. Long-term cast caused: (i) a reduction in the number of sites where complex forelimb movement could be evoked; (ii) a shrinkage of functional zones but no change in their center of gravity; (iii) a reduction in movement with proximal/distal coactivation; (iv) a reduction in maximal velocity, trajectory and vector length of movement, but no changes in latency or duration; (v) a large restriction of reachable space. Fourteen days of forelimb freedom after casting caused: (i) a recovery of the number of sites where complex forelimb movement could be evoked; (ii) a recovery of functional zone extent and movement with proximal/distal coactivation; (iii) an increase in movement kinematics, but only partial restoration of control rat values; (iv) a slight increase in reachability parameters, but these remained far below baseline values. We pose the hypothesis that specific aspects of complex movement may be stored within parallel motor cortex re-entrant systems.

  5. Sensorimotor restriction affects complex movement topography and reachable space in the rat motor cortex

    PubMed Central

    Budri, Mirco; Lodi, Enrico; Franchi, Gianfranco

    2014-01-01

    Long-duration intracortical microstimulation (ICMS) studies with 500 ms of current pulses suggest that the forelimb area of the motor cortex is organized into several spatially distinct functional zones that organize movements into complex sequences. Here we studied how sensorimotor restriction modifies the extent of functional zones, complex movements, and reachable space representation in the rat forelimb M1. Sensorimotor restriction was achieved by means of whole-forelimb casting of 30 days duration. Long-duration ICMS was carried out 12 h and 14 days after cast removal. Evoked movements were measured using a high-resolution 3D optical system. Long-term cast caused: (i) a reduction in the number of sites where complex forelimb movement could be evoked; (ii) a shrinkage of functional zones but no change in their center of gravity; (iii) a reduction in movement with proximal/distal coactivation; (iv) a reduction in maximal velocity, trajectory and vector length of movement, but no changes in latency or duration; (v) a large restriction of reachable space. Fourteen days of forelimb freedom after casting caused: (i) a recovery of the number of sites where complex forelimb movement could be evoked; (ii) a recovery of functional zone extent and movement with proximal/distal coactivation; (iii) an increase in movement kinematics, but only partial restoration of control rat values; (iv) a slight increase in reachability parameters, but these remained far below baseline values. We pose the hypothesis that specific aspects of complex movement may be stored within parallel motor cortex re-entrant systems. PMID:25565987

  6. Radiant zone heated particulate filter

    DOEpatents

    Gonze, Eugene V [Pinckney, MI

    2011-12-27

    A system includes a particulate matter (PM) filter including an upstream end for receiving exhaust gas and a downstream end. A radiant zoned heater includes N zones, where N is an integer greater than one, wherein each of the N zones includes M sub-zones, where M is an integer greater than or equal to one. A control module selectively activates at least a selected one of the N zones to initiate regeneration in downstream portions of the PM filter from the one of the N zones, restricts exhaust gas flow in a portion of the PM filter that corresponds to the selected one of the N zones, and deactivates non-selected ones of the N zones.

  7. Egypt: World Oil Report 1991

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1991-08-01

    This paper reports on a selective ban on exploration for oil and gas that resulted for offshore and onshore areas of the Red Sea and South Sinai. Egypt is a new hot spot for environmental concerns. After six months of debate, three concessions in the southern Gulf of Suez were reopened for exploration in late 1990. Companies can resume seismic work and eventually drill, but only in a zone from the shoreline inland and under certain restrictions. If oil is found in the restricted area, discovery wells must be plugged and the location restored. If commercial, companies must go outsidemore » the restricted zone and drill deviated wells. Three companies directly involved are Asamera Egypt (Gulf Canada), Germany's Deminex and Exxon. All foreign exploration companies are now required to submit environmental impact statements.« less

  8. 33 CFR 334.855 - Salt River, Rolling Fork River, Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation; Fort Knox, Kentucky; danger zone. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.855 Salt River, Rolling Fork River, Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation; Fort Knox, Kentucky; danger zone. (a...

  9. 33 CFR 334.855 - Salt River, Rolling Fork River, Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation; Fort Knox, Kentucky; danger zone. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.855 Salt River, Rolling Fork River, Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation; Fort Knox, Kentucky; danger zone. (a...

  10. 33 CFR 334.855 - Salt River, Rolling Fork River, Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation; Fort Knox, Kentucky; danger zone. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.855 Salt River, Rolling Fork River, Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation; Fort Knox, Kentucky; danger zone. (a...

  11. 33 CFR 334.855 - Salt River, Rolling Fork River, Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation; Fort Knox, Kentucky; danger zone. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.855 Salt River, Rolling Fork River, Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation; Fort Knox, Kentucky; danger zone. (a...

  12. 33 CFR 334.855 - Salt River, Rolling Fork River, Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation; Fort Knox, Kentucky; danger zone. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.855 Salt River, Rolling Fork River, Otter Creek; U.S. Army Garrison, Fort Knox Military Reservation; Fort Knox, Kentucky; danger zone. (a...

  13. 33 CFR 100.T05-0443 - Safety Zone; Fireworks Display, Delaware River, New Hope, PA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., Delaware River, New Hope, PA. 100.T05-0443 Section 100.T05-0443 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY REGATTAS AND MARINE PARADES SAFETY OF LIFE ON NAVIGABLE WATERS § 100.T05-0443 Safety Zone; Fireworks Display, Delaware River, New Hope, PA. (a) Location. The safety zone will restrict...

  14. 33 CFR 334.480 - Archers Creek, Ribbon Creek, and Broad River; U.S. Marine Corps Recruit Depot, Parris Island...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Broad River; U.S. Marine Corps Recruit Depot, Parris Island, South Carolina; danger zones. 334.480... DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.480 Archers Creek, Ribbon Creek, and Broad River... danger zone on Archers Creek (between the Broad River and Beaufort River), Ribbon Creek, and the Broad...

  15. 33 CFR 334.480 - Archers Creek, Ribbon Creek, and Broad River; U.S. Marine Corps Recruit Depot, Parris Island...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Broad River; U.S. Marine Corps Recruit Depot, Parris Island, South Carolina; danger zones. 334.480... DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.480 Archers Creek, Ribbon Creek, and Broad River... danger zone on Archers Creek (between the Broad River and Beaufort River), Ribbon Creek, and the Broad...

  16. 33 CFR 334.480 - Archers Creek, Ribbon Creek, and Broad River; U.S. Marine Corps Recruit Depot, Parris Island...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Broad River; U.S. Marine Corps Recruit Depot, Parris Island, South Carolina; danger zones. 334.480... DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.480 Archers Creek, Ribbon Creek, and Broad River... danger zone on Archers Creek (between the Broad River and Beaufort River), Ribbon Creek, and the Broad...

  17. 33 CFR 334.1050 - Oakland Outer Harbor adjacent to the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of Oakland Berth No. 10); restricted area. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1050 Oakland Outer Harbor adjacent to the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of Oakland Berth No. 10); restricted area. (a...

  18. 33 CFR 334.1050 - Oakland Outer Harbor adjacent to the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of Oakland Berth No. 10); restricted area. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1050 Oakland Outer Harbor adjacent to the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of Oakland Berth No. 10); restricted area. (a...

  19. 33 CFR 334.1050 - Oakland Outer Harbor adjacent to the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of Oakland Berth No. 10); restricted area. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1050 Oakland Outer Harbor adjacent to the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of Oakland Berth No. 10); restricted area. (a...

  20. 33 CFR 334.1050 - Oakland Outer Harbor adjacent to the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of Oakland Berth No. 10); restricted area. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1050 Oakland Outer Harbor adjacent to the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of Oakland Berth No. 10); restricted area. (a...

  1. 33 CFR 334.1050 - Oakland Outer Harbor adjacent to the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of Oakland Berth No. 10); restricted area. 334..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1050 Oakland Outer Harbor adjacent to the Military Ocean Terminal, Bay Area, Pier No. 8 (Port of Oakland Berth No. 10); restricted area. (a...

  2. An automatic DI-flux at the Livingston Island geomagnetic observatory, Antarctica: requirements and lessons learned

    NASA Astrophysics Data System (ADS)

    Marsal, Santiago; José Curto, Juan; Torta, Joan Miquel; Gonsette, Alexandre; Favà, Vicent; Rasson, Jean; Ibañez, Miquel; Cid, Òscar

    2017-07-01

    The DI-flux, consisting of a fluxgate magnetometer coupled with a theodolite, is used for the absolute manual measurement of the magnetic field angles in most ground-based observatories worldwide. Commercial solutions for an automated DI-flux have recently been developed by the Royal Meteorological Institute of Belgium (RMI), and are practically restricted to the AutoDIF and its variant, the GyroDIF. In this article, we analyze the pros and cons of both instruments in terms of its suitability for installation at the partially manned geomagnetic observatory of Livingston Island (LIV), Antarctica. We conclude that the GyroDIF, even if it is less accurate and more power demanding, is more suitable than the AutoDIF for harsh conditions due to the simpler infrastructure that is necessary. Power constraints in the Spanish Antarctic Station Juan Carlos I (ASJI) during the unmanned season require an energy-efficient design of the thermally regulated box housing the instrument as well as thorough power management. Our experiences can benefit the geomagnetic community, which often faces similar challenges.

  3. A walk through the planned CS building. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Khorramabadi, Delnaz

    1991-01-01

    Using the architectural plan views of our future computer science building as test objects, we have completed the first stage of a Building walkthrough system. The inputs to our system are AutoCAD files. An AutoCAD converter translates the geometrical information in these files into a format suitable for 3D rendering. Major model errors, such as incorrect polygon intersections and random face orientations, are detected and fixed automatically. Interactive viewing and editing tools are provided to view the results, to modify and clean the model and to change surface attributes. Our display system provides a simple-to-use user interface for interactive exploration of buildings. Using only the mouse buttons, the user can move inside and outside the building and change floors. Several viewing and rendering options are provided, such as restricting the viewing frustum, avoiding wall collisions, and selecting different rendering algorithms. A plan view of the current floor, with the position of the eye point and viewing direction on it, is displayed at all times. The scene illumination can be manipulated, by interactively controlling intensity values for 5 light sources.

  4. 15 CFR 923.12 - Uses of regional benefit.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...) NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE OCEAN AND COASTAL RESOURCE MANAGEMENT COASTAL ZONE MANAGEMENT PROGRAM REGULATIONS Uses Subject to Management § 923.12 Uses of regional... regulations within the coastal zone do not unreasonably restrict or exclude land uses and water uses of...

  5. Thyroid associated orbitopathy

    PubMed Central

    Verma, Rajesh; Gupta, Mani; Mehta, Vinod Kumar

    2013-01-01

    Thyroid-associated orbitopathy (TAO) is a self-limiting auto-immune condition usually associated with Grave's disease. It is characterised by ocular pain, eyelid swelling, chemosis, proptosis and keratopathy. As the mechanism for ophthamoplegia and optic neuropathy is the orbital swelling leading to mechanical restriction of ocular muscles and compression of optic nerve, one expects proptosis rather than ptosis in TAO. We describe a case of a young adult woman who presented with acute onset restriction of movement along with partial ptosis and severe diminution of vision in left eye. The MRI of orbit revealed significant swelling of recti along with signal alteration consistent with TAO. The radio-isotope thyroid scan revealed thyroiditis, and thyroid peroxidase (TPO) antibody was significantly high; hence, the diagnosis of Hashimoto thyroiditis was considered. A course of intravenous methylprednisolone followed by oral steroid was administered, which produced marked improvement in vision and extraocular movement. PMID:23737589

  6. Temporally resolved planar measurements of transient phenomena in a partially pre-mixed swirl flame in a gas turbine model combustor

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Boxx, I.; Stoehr, M.; Meier, W.

    This paper presents observations and analysis of the time-dependent behavior of a 10 kW partially pre-mixed, swirl-stabilized methane-air flame exhibiting self-excited thermo-acoustic oscillations. This analysis is based on a series of measurements wherein particle image velocimetry (PIV) and planar laser-induced fluorescence (PLIF) of the OH radical were performed simultaneously at 5 kHz repetition rate over durations of 0.8 s. Chemiluminescence imaging of the OH{sup *} radical was performed separately, also at 5 kHz over 0.8 s acquisition runs. These measurements were of sufficient sampling frequency and duration to extract usable spatial and temporal frequency information on the medium to large-scalemore » flow-field and heat-release characteristics of the flame. This analysis is used to more fully characterize the interaction between the self-excited thermo-acoustic oscillations and the dominant flow-field structure of this flame, a precessing vortex core (PVC) present in the inner recirculation zone. Interpretation of individual measurement sequences yielded insight into various physical phenomena and the underlying mechanisms driving flame dynamics. It is observed for this flame that location of the reaction zone tracks large-scale fluctuations in axial velocity and also conforms to the passage of large-scale vortical structures through the flow-field. Local extinction of the reaction zone in regions of persistently high principal compressive strain is observed. Such extinctions, however, are seen to be self healing and thus do not induce blowout. Indications of auto-ignition in regions of unburned gas near the exit are also observed. Probable auto-ignition events are frequently observed coincident with the centers of large-scale vortical structures, suggesting the phenomenon is linked to the enhanced mixing and longer residence times associated with fluid at the core of the PVC as it moves through the flame. (author)« less

  7. 33 CFR 334.763 - Naval Support Activity Panama City; Gulf of Mexico; restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334..., 085°47′29″ W; West point—30°07′55″ N, 085°51′05″ W, then northerly to point of origin. (b) The restrictions. (1) For the purposes of this section, “military security zones” are specific portion/s within any...

  8. 15 CFR 400.28 - Conditions, prohibitions and restrictions applicable to grants of authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Conditions, prohibitions and restrictions applicable to grants of authority. 400.28 Section 400.28 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) FOREIGN-TRADE ZONES BOARD, DEPARTMENT OF COMMERCE...

  9. Autologous/Allogeneic Hematopoietic Cell Transplantation versus Tandem Autologous Transplantation for Multiple Myeloma: Comparison of Long-Term Postrelapse Survival.

    PubMed

    Htut, Myo; D'Souza, Anita; Krishnan, Amrita; Bruno, Benedetto; Zhang, Mei-Jie; Fei, Mingwei; Diaz, Miguel Angel; Copelan, Edward; Ganguly, Siddhartha; Hamadani, Mehdi; Kharfan-Dabaja, Mohamed; Lazarus, Hillard; Lee, Cindy; Meehan, Kenneth; Nishihori, Taiga; Saad, Ayman; Seo, Sachiko; Ramanathan, Muthalagu; Usmani, Saad Z; Gasparetto, Christina; Mark, Tomer M; Nieto, Yago; Hari, Parameswaran

    2018-03-01

    We compared postrelapse overall survival (OS) after autologous/allogeneic (auto/allo) versus tandem autologous (auto/auto) hematopoietic cell transplantation (HCT) in patients with multiple myeloma (MM). Postrelapse survival of patients receiving an auto/auto or auto/allo HCT for MM and prospectively reported to the Center for International Blood and Marrow Transplant Research between 2000 and 2010 were analyzed. Relapse occurred in 404 patients (72.4%) in the auto/auto group and in 178 patients (67.4%) in the auto/allo group after a median follow-up of 8.5 years. Relapse occurred before 6 months after a second HCT in 46% of the auto/allo patients, compared with 26% of the auto/auto patients. The 6-year postrelapse survival was better in the auto/allo group compared with the auto/auto group (44% versus 35%; P = .05). Mortality due to MM was 69% (n = 101) in the auto/allo group and 83% (n = 229) deaths in auto/auto group. In multivariate analysis, both cohorts had a similar risk of death in the first year after relapse (hazard ratio [HR], .72; P = .12); however, for time points beyond 12 months after relapse, overall survival was superior in the auto/allo cohort (HR for death in auto/auto =1.55; P = .005). Other factors associated with superior survival were enrollment in a clinical trial for HCT, male sex, and use of novel agents at induction before HCT. Our findings shown superior survival afterrelapse in auto/allo HCT recipients compared with auto/auto HCT recipients. This likely reflects a better response to salvage therapy, such as immunomodulatory drugs, potentiated by a donor-derived immunologic milieu. Further augmentation of the post-allo-HCT immune system with new immunotherapies, such as monoclonal antibodies, checkpoint inhibitors, and others, merit investigation. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

  10. Optimization of an auto-thermal ammonia synthesis reactor using cyclic coordinate method

    NASA Astrophysics Data System (ADS)

    A-N Nguyen, T.; Nguyen, T.-A.; Vu, T.-D.; Nguyen, K.-T.; K-T Dao, T.; P-H Huynh, K.

    2017-06-01

    The ammonia synthesis system is an important chemical process used in the manufacture of fertilizers, chemicals, explosives, fibers, plastics, refrigeration. In the literature, many works approaching the modeling, simulation and optimization of an auto-thermal ammonia synthesis reactor can be found. However, they just focus on the optimization of the reactor length while keeping the others parameters constant. In this study, the other parameters are also considered in the optimization problem such as the temperature of feed gas enters the catalyst zone, the initial nitrogen proportion. The optimal problem requires the maximization of an objective function which is multivariable function and subject to a number of equality constraints involving the solution of coupled differential equations and also inequality constraint. The cyclic coordinate search was applied to solve the multivariable-optimization problem. In each coordinate, the golden section method was applied to find the maximum value. The inequality constraints were treated using penalty method. The coupled differential equations system was solved using Runge-Kutta 4th order method. The results obtained from this study are also compared to the results from the literature.

  11. 76 FR 37643 - Safety Zone; Delta Independence Day Foundation Celebration, Mandeville Island, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-28

    ... with the pyrotechnics. Unauthorized persons or vessels are prohibited from entering into, transiting... the dangers posed by the pyrotechnics used in this fireworks display, the safety zone is necessary to... fireworks launch site during loading of the pyrotechnics, and during the fireworks display. This restricted...

  12. 75 FR 34376 - Safety Zone; City of Pittsburg Independence Day Celebration, Pittsburg, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... associated with the pyrotechnics. Unauthorized persons or vessels are prohibited from entering into... of the dangers posed by the pyrotechnics used in this fireworks display, the safety zone is necessary... restricted area on the waters surrounding the fireworks launch site during loading of the pyrotechnics, and...

  13. 75 FR 55851 - Flightcrew Member Duty and Rest Requirements

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-14

    ... requirements based on the time of day, whether an individual is acclimated to a new time zone, and the.... Joint Responsibility C. Fatigue Training D. Flight Duty Period E. Acclimating to a New Time Zone F. Daily Flight Time Restrictions G. Mitigation Strategies 1. Augmentation 2. Split Duty Rest H...

  14. 33 CFR 334.870 - San Diego Harbor, Calif.; restricted area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false San Diego Harbor, Calif... THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.870 San Diego Harbor... the Pacific Ocean in North San Diego Bay in an area extending from the western boundary of North...

  15. 33 CFR 334.870 - San Diego Harbor, Calif.; restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false San Diego Harbor, Calif... THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.870 San Diego Harbor... the Pacific Ocean in North San Diego Bay in an area extending from the western boundary of North...

  16. 33 CFR 334.1130 - Pacific Ocean, Western Space and Missile Center (WSMC), Vandenberg AFB, Calif.; danger zones.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Missile Center (WSMC), Vandenberg AFB, Calif.; danger zones. 334.1130 Section 334.1130 Navigation and... RESTRICTED AREA REGULATIONS § 334.1130 Pacific Ocean, Western Space and Missile Center (WSMC), Vandenberg AFB... Point Arguello, unless prior permission is obtained from the Commander, Western Space and Missile Center...

  17. 33 CFR 334.1130 - Pacific Ocean, Western Space and Missile Center (WSMC), Vandenberg AFB, Calif.; danger zones.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Missile Center (WSMC), Vandenberg AFB, Calif.; danger zones. 334.1130 Section 334.1130 Navigation and... RESTRICTED AREA REGULATIONS § 334.1130 Pacific Ocean, Western Space and Missile Center (WSMC), Vandenberg AFB... Point Arguello, unless prior permission is obtained from the Commander, Western Space and Missile Center...

  18. 33 CFR 334.1130 - Pacific Ocean, Western Space and Missile Center (WSMC), Vandenberg AFB, Calif.; danger zones.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Missile Center (WSMC), Vandenberg AFB, Calif.; danger zones. 334.1130 Section 334.1130 Navigation and... RESTRICTED AREA REGULATIONS § 334.1130 Pacific Ocean, Western Space and Missile Center (WSMC), Vandenberg AFB... Point Arguello, unless prior permission is obtained from the Commander, Western Space and Missile Center...

  19. 33 CFR 334.1130 - Pacific Ocean, Western Space and Missile Center (WSMC), Vandenberg AFB, Calif.; danger zones.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Missile Center (WSMC), Vandenberg AFB, Calif.; danger zones. 334.1130 Section 334.1130 Navigation and... RESTRICTED AREA REGULATIONS § 334.1130 Pacific Ocean, Western Space and Missile Center (WSMC), Vandenberg AFB... Point Arguello, unless prior permission is obtained from the Commander, Western Space and Missile Center...

  20. 33 CFR 334.1130 - Pacific Ocean, Western Space and Missile Center (WSMC), Vandenberg AFB, Calif.; danger zones.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Missile Center (WSMC), Vandenberg AFB, Calif.; danger zones. 334.1130 Section 334.1130 Navigation and... RESTRICTED AREA REGULATIONS § 334.1130 Pacific Ocean, Western Space and Missile Center (WSMC), Vandenberg AFB... Point Arguello, unless prior permission is obtained from the Commander, Western Space and Missile Center...

  1. 78 FR 39599 - Safety Zone; Fort Monroe Fireworks Display, Chesapeake Bay, Hampton, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    .... ACTION: Temporary Final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone on the... intended to restrict vessel traffic movement in the specified area in order to protect the life and... Federal holidays. FOR FURTHER INFORMATION CONTACT: If you have questions on this temporary rule, call or...

  2. 78 FR 53668 - Regulated Navigation Area; Maine Kennebec Bridge Construction Zone, Kennebec River, Richmond, ME

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-30

    ...-AA11 Regulated Navigation Area; Maine Kennebec Bridge Construction Zone, Kennebec River, Richmond, ME... surrounding the Maine Kennebec Bridge between Richmond, ME, and Dresden, ME. This RNA allows the Coast Guard to enforce speed and wake restrictions and prohibit all vessel traffic through the RNA during bridge...

  3. 77 FR 65621 - Security Zone; Cruise Ships, Santa Barbara Harbor, Santa Barbara, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-30

    ... able to locate the cruise ships visually, due to the small geographic size and depth restrictions of... entities because vessel traffic can pass safely around the zones. If you think that your business... significant economic impact on it, please submit a comment (see ADDRESSES) explaining why you think it...

  4. 77 FR 31183 - Safety Zone, Temporary Change for Recurring Fireworks Display Within the Fifth Coast Guard...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-25

    ...-AA00 Safety Zone, Temporary Change for Recurring Fireworks Display Within the Fifth Coast Guard District, Pamlico River and Tar River; Washington, NC AGENCY: Coast Guard, DHS. ACTION: Temporary final... is intended to restrict vessel traffic in a portion of the Pamlico River and Tar River near...

  5. EphrinB3 restricts endogenous neural stem cell migration after traumatic brain injury.

    PubMed

    Dixon, Kirsty J; Mier, Jose; Gajavelli, Shyam; Turbic, Alisa; Bullock, Ross; Turnley, Ann M; Liebl, Daniel J

    2016-11-01

    Traumatic brain injury (TBI) leads to a series of pathological events that can have profound influences on motor, sensory and cognitive functions. Conversely, TBI can also stimulate neural stem/progenitor cell proliferation leading to increased numbers of neuroblasts migrating outside their restrictive neurogenic zone to areas of damage in support of tissue integrity. Unfortunately, the factors that regulate migration are poorly understood. Here, we examine whether ephrinB3 functions to restrict neuroblasts from migrating outside the subventricular zone (SVZ) and rostral migratory stream (RMS). We have previously shown that ephrinB3 is expressed in tissues surrounding these regions, including the overlying corpus callosum (CC), and is reduced after controlled cortical impact (CCI) injury. Our current study takes advantage of ephrinB3 knockout mice to examine the influences of ephrinB3 on neuroblast migration into CC and cortex tissues after CCI injury. Both injury and/or ephrinB3 deficiency led to increased neuroblast numbers and enhanced migration outside the SVZ/RMS zones. Application of soluble ephrinB3-Fc molecules reduced neuroblast migration into the CC after injury and limited neuroblast chain migration in cultured SVZ explants. Our findings suggest that ephrinB3 expression in tissues surrounding neurogenic regions functions to restrict neuroblast migration outside the RMS by limiting chain migration. Copyright © 2016 Michael Boutros, German Cancer Research Center, Heidelberg, Germany. Published by Elsevier B.V. All rights reserved.

  6. Rotational Collision Apparatus for Indoor Egg Drops

    NASA Astrophysics Data System (ADS)

    Halada, Richard

    2003-05-01

    Our units about momentum and energy are richly illustrated with applications to car crashes and explanations of such safety features as airbags and crumple zones. The main lab exercise, however, is an egg crash (car insurance rates being so much higher). Fairly standard rules apply: Students must devise an "egg-protection package" that will keep a teacher-supplied egg intact through two successive impacts. After the test, they must hand in a written analysis of the specific physics principles they employed, modifications they would make after seeing their project's actual performance, and suggestions for applying their protection system to auto safety.

  7. Multizone accretional evolution of planetesimal swarms

    NASA Technical Reports Server (NTRS)

    Spaute, D.; Davis, D. R.; Weidenschilling, S. J.

    1990-01-01

    The general features of a new numerical simulation of planetesimal accretion which models multiple heliocentric distance zones, together with a detailed model for the planetesimal size and orbital distribution in each zone, are described. A restricted version of this model which allows only a single heliocentric distance zone has been used to test the validity of the code by comparing with results from earlier authors when the same physical phenomena are included. Generally, very good agreement is found.

  8. Origin of the Blytheville Arch, and long-term displacement on the New Madrid seismic zone, central United States

    USGS Publications Warehouse

    Pratt, Thomas L.; Williams, Robert; Odum, Jackson K.; Stephenson, William J.

    2013-01-01

    The southern arm of the New Madrid seismic zone of the central United States coincides with the buried, ~110 km by ~20 km Blytheville Arch antiform within the Cambrian–Ordovician Reelfoot rift graben. The Blytheville Arch has been interpreted at various times as a compressive structure, an igneous intrusion, or a sediment diapir. Reprocessed industry seismic-reflection profiles presented here show a strong similarity between the Blytheville Arch and pop-up structures, or flower structures, within strike-slip fault systems. The Blytheville Arch formed in the Paleozoic, but post–Mid-Cretaceous to Quaternary strata show displacement or folding indicative of faulting. Faults within the graben structure but outside of the Blytheville Arch also appear to displace Upper Cretaceous and perhaps younger strata, indicating that past faulting was not restricted to the Blytheville Arch and New Madrid seismic zone. As much as 10–12.5 km of strike slip can be estimated from apparent shearing of the Reelfoot arm of the New Madrid seismic zone. There also appears to be ~5–5.5 km of shearing of the Reelfoot topographic scarp at the north end of the southern arm of the New Madrid seismic zone and of the southern portion of Crowley's Ridge, which is a north-trending topographic ridge just south of the seismic zone. These observations suggest that there has been substantial strike-slip displacement along the Blytheville Arch and southern arm of the New Madrid seismic zone, that strike-slip extended north and south of the modern seismic zone, and that post–Mid-Cretaceous (post-Eocene?) faulting was not restricted to the Blytheville Arch or to currently active faults within the New Madrid seismic zone.

  9. Tandem Autologous versus Single Autologous Transplantation Followed by Allogeneic Hematopoietic Cell Transplantation for Patients with Multiple Myeloma: Results from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0102 Trial

    PubMed Central

    Krishnan, Amrita; Pasquini, Marcelo C.; Logan, Brent; Stadtmauer, Edward A.; Vesole, David H.; Alyea, Edwin; Antin, Joseph H.; Comenzo, Raymond; Goodman, Stacey; Hari, Parameswaran; Laport, Ginna; Qazilbash, Muzaffar H.; Rowley, Scott; Sahebi, Firoozeh; Somlo, George; Vogl, Dan T.; Weisdorf, Daniel; Ewell, Marian; Wu, Juan; Geller, Nancy L.; Horowitz, Mary M.; Giralt, Sergio; Maloney, David G.

    2012-01-01

    Background Autologous hematopoietic cell transplantation (HCT) improves survival in patients with multiple myeloma, but disease progression remains a challenge. Allogeneic HCT (alloHCT) has the potential to reduce disease progression through graft-versus-myeloma effects. The aim of the BMT CTN 0102 trial was to compare outcomes of autologous HCT (autoHCT) followed by alloHCT with non-myeloablative conditioning (auto-allo) to tandem autoHCT (auto-auto) in patients with standard risk myeloma. Patients in the auto-auto arm were randomized to one year of thalidomide and dexamethasone (Thal-Dex) maintenance therapy or observation (Obs). Methods Patients with multiple myeloma within 10 months from initiation of induction therapy were classified as standard (SRD) or high risk (HRD) disease based on cytogenetics and beta-2-microglobulin levels. Assignment to auto-allo HCT was based on availability of an HLA-matched sibling donor. Primary endpoint was three-year progression-free survival (PFS) according to intent-to-treat analysis. Results 710 patients were enrolled completed a minimum of 3-year follow up. Among 625 SRD patients, 189 and 436 were assigned to auto-allo and auto-auto, respectively. Seventeen percent (33/189) of SR patients in the auto-allo arm and 16% (70/436) in the auto-auto arm did not receive a second transplant. Thal-Dex was not completed in 77% (168/217) of assigned patients. PFS and overall survival (OS) did not differ between the Thal-Dex (49%, 80%) and Obs (41%, 81%) cohorts and these two arms were pooled for analysis. Three year PFS was 43% and 46% (p=0·671) and three-year OS was 77% and 80 % (p=0·191) with auto-allo and auto-auto, respectively. Corresponding progression/relapse rates were 46% and 50% (p=0·402); treatment-related mortality rates were 11% and 4% (p<0·001), respectively. Auto/allo patients with chronic graft-vs-host disease had a decreased risk of relapse. Most common grade 3 to 5 adverse events in auto-allo was hypebilirubenemia (21/189) and in the auto-auto was peripheral neuropathy (52/436). Among 85 HRD patients (37 auto-allo), three PFS was 40% and 33% (p=0·743) and three-year OS was 59% and 67% (p=0·460) with auto-allo and auto-auto, respectively. Conclusion Thal-Dex maintenance was associated with poor compliance and did not improve PFS or OS. At three years there was no improvement in PFS or OS with auto-allo compared to auto-auto transplantation in patients with standard risk myeloma. Decisions to proceed with alloHCT after an autoHCT in patients with standard risk myeloma should take into consideration results of the current trial. Future investigation of alloHCT in myeloma should focus to minimize TRM and maximize graft-versus myeloma effects. This trial was registered in Clinicaltrials.gov (NCT00075829) and was funded by the National Heart, Lung and Blood Institute and National Cancer Institute. PMID:21962393

  10. 33 CFR 334.860 - San Diego Bay, Calif., Naval Amphibious Base; restricted area.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false San Diego Bay, Calif., Naval..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.860 San Diego... Middle San Diego Bay in an area extending from the northern and eastern boundary of the Naval Amphibious...

  11. 33 CFR 334.860 - San Diego Bay, Calif., Naval Amphibious Base; restricted area.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false San Diego Bay, Calif., Naval..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.860 San Diego... Middle San Diego Bay in an area extending from the northern and eastern boundary of the Naval Amphibious...

  12. 33 CFR 334.860 - San Diego Bay, Calif.; Naval Amphibious Base; restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false San Diego Bay, Calif.; Naval..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.860 San Diego... Middle San Diego Bay in an area extending from the northern and eastern boundary of the Naval Amphibious...

  13. A Nonparametric Approach to Automated S-Wave Picking

    NASA Astrophysics Data System (ADS)

    Rawles, C.; Thurber, C. H.

    2014-12-01

    Although a number of very effective P-wave automatic pickers have been developed over the years, automatic picking of S waves has remained more challenging. Most automatic pickers take a parametric approach, whereby some characteristic function (CF), e.g. polarization or kurtosis, is determined from the data and the pick is estimated from the CF. We have adopted a nonparametric approach, estimating the pick directly from the waveforms. For a particular waveform to be auto-picked, the method uses a combination of similarity to a set of seismograms with known S-wave arrivals and dissimilarity to a set of seismograms that do not contain S-wave arrivals. Significant effort has been made towards dealing with the problem of S-to-P conversions. We have evaluated the effectiveness of our method by testing it on multiple sets of microearthquake seismograms with well-determined S-wave arrivals for several areas around the world, including fault zones and volcanic regions. In general, we find that the results from our auto-picker are consistent with reviewed analyst picks 90% of the time at the 0.2 s level and 80% of the time at the 0.1 s level, or better. For most of the large datasets we have analyzed, our auto-picker also makes far more S-wave picks than were made previously by analysts. We are using these enlarged sets of high-quality S-wave picks to refine tomographic inversions for these areas, resulting in substantial improvement in the quality of the S-wave images. We will show examples from New Zealand, Hawaii, and California.

  14. Ancestral chloroplast polymorphism and historical secondary contact in a broad hybrid zone of Aesculus (Sapindaceae).

    PubMed

    Modliszewski, Jennifer L; Thomas, David T; Fan, Chuanzhu; Crawford, Daniel J; Depamphilis, Claude W; Xiang, Qiu-Yun Jenny

    2006-03-01

    Knowledge regarding the origin and maintenance of hybrid zones is critical for understanding the evolutionary outcomes of natural hybridization. To evaluate the contribution of historical contact vs. long-distance gene flow in the formation of a broad hybrid zone in central and northern Georgia that involves Aesculus pavia, A. sylvatica, and A. flava, three cpDNA regions (matK, trnD-trnT, and trnH-trnK) were analyzed. The maternal inheritance of cpDNA in Aesculus was confirmed via sequencing of matK from progeny of controlled crosses. Restriction site analyses identified 21 unique haplotypes among 248 individuals representing 29 populations from parental species and hybrids. Haplotypes were sequenced for all cpDNA regions. Restriction site and sequence data were subjected to phylogeographic and population genetic analyses. Considerable cpDNA variation was detected in the hybrid zone, as well as ancestral cpDNA polymorphism; furthermore, the distribution of haplotypes indicates limited interpopulation gene flow via seeds. The genealogy and structure of genetic variation further support the historical presence of A. pavia in the Piedmont, although they are at present locally extinct. In conjunction with previous allozyme studies, the cpDNA data suggest that the hybrid zone originated through historical local gene flow, yet is maintained by periodic long-distance pollen dispersal.

  15. 77 FR 35848 - Safety Zone, Fourth of July Fireworks Event, Pagan River, Smithfield, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    .... ACTION: Temporary Final rule. SUMMARY: The Coast Guard is establishing a 420-foot radius safety zone on..., and falling hot embers or other debris, vessel traffic will be temporarily restricted within 420 feet... navigable waters of the Pagan River within the area bounded by a 420-foot radius circle centered on position...

  16. 75 FR 34934 - Safety Zone; Fireworks for the Virginia Lake Festival, Buggs Island Lake, Clarksville, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ...-AA00 Safety Zone; Fireworks for the Virginia Lake Festival, Buggs Island Lake, Clarksville, VA AGENCY... Fireworks for the Virginia Lake Festival event. This action is intended to restrict vessel traffic movement... Virginia Lake Festival, Buggs Island Lake, Clarksville, VA (a) Regulated Area. The following area is a...

  17. 77 FR 34798 - Safety Zone; USMMA Fireworks, Long Island Sound, Kings Point, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... 1625-AA00 Safety Zone; USMMA Fireworks, Long Island Sound, Kings Point, NY AGENCY: Coast Guard, DHS... navigable waters of Long Island Sound in the vicinity of Kings Point, NY for a fireworks display. This... fireworks displays. This rule is intended to restrict all vessels from a portion of Long Island Sound before...

  18. 75 FR 26157 - Safety Zone; Reedville July 4th Celebration, Cockrell's Creek, Reedville, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ...-AA00 Safety Zone; Reedville July 4th Celebration, Cockrell's Creek, Reedville, VA AGENCY: Coast Guard... Reedville July 4th Celebration event. This action is intended to restrict vessel traffic movement on... established in the interest of public safety during the Reedville July 4th Celebration event and will be...

  19. 76 FR 75453 - Restricted Areas and Danger Zones at Eglin Air Force Base, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... and Danger Zones at Eglin Air Force Base, FL AGENCY: U.S. Army Corps of Engineers, Department of... within the Eglin Air Force Base (AFB) facilities and along the Eglin AFB facility shoreline in Florida... have the permission of the Commander, 96 Air Base Wing, Eglin AFB or his/her authorized representative...

  20. Distributed parameter system coupled ARMA expansion identification and adaptive parallel IIR filtering - A unified problem statement. [Auto Regressive Moving-Average

    NASA Technical Reports Server (NTRS)

    Johnson, C. R., Jr.; Balas, M. J.

    1980-01-01

    A novel interconnection of distributed parameter system (DPS) identification and adaptive filtering is presented, which culminates in a common statement of coupled autoregressive, moving-average expansion or parallel infinite impulse response configuration adaptive parameterization. The common restricted complexity filter objectives are seen as similar to the reduced-order requirements of the DPS expansion description. The interconnection presents the possibility of an exchange of problem formulations and solution approaches not yet easily addressed in the common finite dimensional lumped-parameter system context. It is concluded that the shared problems raised are nevertheless many and difficult.

  1. Multivariable optimization of an auto-thermal ammonia synthesis reactor using genetic algorithm

    NASA Astrophysics Data System (ADS)

    Anh-Nga, Nguyen T.; Tuan-Anh, Nguyen; Tien-Dung, Vu; Kim-Trung, Nguyen

    2017-09-01

    The ammonia synthesis system is an important chemical process used in the manufacture of fertilizers, chemicals, explosives, fibers, plastics, refrigeration. In the literature, many works approaching the modeling, simulation and optimization of an auto-thermal ammonia synthesis reactor can be found. However, they just focus on the optimization of the reactor length while keeping the others parameters constant. In this study, the other parameters are also considered in the optimization problem such as the temperature of feed gas enters the catalyst zone. The optimal problem requires the maximization of a multivariable objective function which subjects to a number of equality constraints involving the solution of coupled differential equations and also inequality constraints. The solution of an optimization problem can be found through, among others, deterministic or stochastic approaches. The stochastic methods, such as evolutionary algorithm (EA), which is based on natural phenomenon, can overcome the drawbacks such as the requirement of the derivatives of the objective function and/or constraints, or being not efficient in non-differentiable or discontinuous problems. Genetic algorithm (GA) which is a class of EA, exceptionally simple, robust at numerical optimization and is more likely to find a true global optimum. In this study, the genetic algorithm is employed to find the optimum profit of the process. The inequality constraints were treated using penalty method. The coupled differential equations system was solved using Runge-Kutta 4th order method. The results showed that the presented numerical method could be applied to model the ammonia synthesis reactor. The optimum economic profit obtained from this study are also compared to the results from the literature. It suggests that the process should be operated at higher temperature of feed gas in catalyst zone and the reactor length is slightly longer.

  2. Seismic Structure of Perth Basin (Australia) and surroundings from Passive Seismic Deployments

    NASA Astrophysics Data System (ADS)

    Issa, N.; Saygin, E.; Lumley, D. E.; Hoskin, T. E.

    2016-12-01

    We image the subsurface structure of Perth Basin, Western Australia and surroundings by using ambient seismic noise data from 14 seismic stations recently deployed by University of Western Australia (UWA) and other available permanent stations from Geoscience Australia seismic network and the Australian Seismometers in Schools program. Each of these 14 UWA seismic stations comprises a broadband sensor and a high fidelity 3-component 10 Hz geophone, recording in tandem at 250 Hz and 1000 Hz. The other stations used in this study are equipped with short period and broadband sensors. In addition, one shallow borehole station is operated with eight 3 component geophones at depths of between 2 and 44 m. The network is deployed to characterize natural seismicity in the basin and to try and identify any microseismic activity across Darling Fault Zone (DFZ), bounding the basin to the east. The DFZ stretches to approximately 1000 km north-south in Western Australia, and is one of the longest fault zones on the earth with a limited number of detected earthquakes. We use seismic noise cross- and auto-correlation methods to map seismic velocity perturbations across the basin and the transition from DFZ to the basin. Retrieved Green's functions are stable and show clear dispersed waveforms. Travel times of the surface wave Green's functions from noise cross-correlations are inverted with a two-step probabilistic framework to map the absolute shear wave velocities as a function of depth. The single station auto-correlations from the seismic noise yields P wave reflectivity under each station, marking the major discontinuities. Resulting images show the shear velocity perturbations across the region. We also quantify the variation of ambient seismic noise at different depths in the near surface using the geophones in the shallow borehole array.

  3. Clinical assessment of auto-positive end-expiratory pressure by diaphragmatic electrical activity during pressure support and neurally adjusted ventilatory assist.

    PubMed

    Bellani, Giacomo; Coppadoro, Andrea; Patroniti, Nicolò; Turella, Marta; Arrigoni Marocco, Stefano; Grasselli, Giacomo; Mauri, Tommaso; Pesenti, Antonio

    2014-09-01

    Auto-positive end-expiratory pressure (auto-PEEP) may substantially increase the inspiratory effort during assisted mechanical ventilation. Purpose of this study was to assess whether the electrical activity of the diaphragm (EAdi) signal can be reliably used to estimate auto-PEEP in patients undergoing pressure support ventilation and neurally adjusted ventilatory assist (NAVA) and whether NAVA was beneficial in comparison with pressure support ventilation in patients affected by auto-PEEP. In 10 patients with a clinical suspicion of auto-PEEP, the authors simultaneously recorded EAdi, airway, esophageal pressure, and flow during pressure support and NAVA, whereas external PEEP was increased from 2 to 14 cm H2O. Tracings were analyzed to measure apparent "dynamic" auto-PEEP (decrease in esophageal pressure to generate inspiratory flow), auto-EAdi (EAdi value at the onset of inspiratory flow), and IDEAdi (inspiratory delay between the onset of EAdi and the inspiratory flow). The pressure necessary to overcome auto-PEEP, auto-EAdi, and IDEAdi was significantly lower in NAVA as compared with pressure support ventilation, decreased with increase in external PEEP, although the effect of external PEEP was less pronounced in NAVA. Both auto-EAdi and IDEAdi were tightly correlated with auto-PEEP (r = 0.94 and r = 0.75, respectively). In the presence of auto-PEEP at lower external PEEP levels, NAVA was characterized by a characteristic shape of the airway pressure. In patients with auto-PEEP, NAVA, compared with pressure support ventilation, led to a decrease in the pressure necessary to overcome auto-PEEP, which could be reliably monitored by the electrical activity of the diaphragm before inspiratory flow onset (auto-EAdi).

  4. Extended residence time centrifugal contactor design modification and centrifugal contactor vane plate valving apparatus for extending mixing zone residence time

    DOEpatents

    Wardle, Kent E.

    2017-06-06

    The present invention provides an annular centrifugal contactor, having a housing adapted to receive a plurality of flowing liquids; a rotor on the interior of the housing; an annular mixing zone, wherein the annular mixing zone has a plurality of fluid retention reservoirs with ingress apertures near the bottom of the annular mixing zone and egress apertures located above the ingress apertures of the annular mixing zone; and an adjustable vane plate stem, wherein the stem can be raised to restrict the flow of a liquid into the rotor or lowered to increase the flow of the liquid into the rotor.

  5. 75 FR 19885 - Restricted Areas and Danger Zone at Naval Station Mayport, FL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-16

    ... will be in place 24 hours a day, seven days a week. Warning signs notifying individuals of the... authorized representative. This restriction will be in place 24 hours a day, seven days a week. Warning signs... areas identified in this section 24 hours a day, 7 days a week. Any person or vessel encroaching within...

  6. 33 CFR 334.102 - Sandy Hook Bay, Naval Weapons Station EARLE, Piers and Terminal Channel, restricted area...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Sandy Hook Bay, Naval Weapons... DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.102 Sandy Hook Bay, Naval Weapons Station EARLE, Piers..., shall be enforced by the Commanding Officer, Naval Weapons Station Earle, and/or other persons or...

  7. 33 CFR 334.102 - Sandy Hook Bay, Naval Weapons Station EARLE, Piers and Terminal Channel, restricted area...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Sandy Hook Bay, Naval Weapons... DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.102 Sandy Hook Bay, Naval Weapons Station EARLE, Piers..., shall be enforced by the Commanding Officer, Naval Weapons Station Earle, and/or other persons or...

  8. 33 CFR 334.102 - Sandy Hook Bay, Naval Weapons Station EARLE, Piers and Terminal Channel, restricted area...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Sandy Hook Bay, Naval Weapons... DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.102 Sandy Hook Bay, Naval Weapons Station EARLE, Piers..., shall be enforced by the Commanding Officer, Naval Weapons Station Earle, and/or other persons or...

  9. 33 CFR 334.102 - Sandy Hook Bay, Naval Weapons Station EARLE, Piers and Terminal Channel, restricted area...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Sandy Hook Bay, Naval Weapons... DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.102 Sandy Hook Bay, Naval Weapons Station EARLE, Piers..., shall be enforced by the Commanding Officer, Naval Weapons Station Earle, and/or other persons or...

  10. 33 CFR 334.102 - Sandy Hook Bay, Naval Weapons Station EARLE, Piers and Terminal Channel, restricted area...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Sandy Hook Bay, Naval Weapons... DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.102 Sandy Hook Bay, Naval Weapons Station EARLE, Piers..., shall be enforced by the Commanding Officer, Naval Weapons Station Earle, and/or other persons or...

  11. 50 CFR Table 5 to Part 679 - Steller Sea Lion Protection Areas Pacific Cod Fisheries Restrictions

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Steller Sea Lion Protection Areas Pacific Cod Fisheries Restrictions 5 Table 5 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OF THE EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt....

  12. 50 CFR Table 5 to Part 679 - Steller Sea Lion Protection Areas Pacific Cod Fisheries Restrictions

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Steller Sea Lion Protection Areas Pacific Cod Fisheries Restrictions 5 Table 5 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OF THE EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt....

  13. 33 CFR 334.280 - James River between the entrance to Skiffes Creek and Mulberry Point, Va.; army training and...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... to Skiffes Creek and Mulberry Point, Va.; army training and small craft testing area. 334.280 Section... DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.280 James River between the entrance to Skiffes Creek and Mulberry Point, Va.; army training and small craft testing area. (a) The restricted area...

  14. 50 CFR Table 6 to Part 679 - Steller Sea Lion Protection Areas Atka Mackerel Fisheries Restrictions

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Steller Sea Lion Protection Areas Atka Mackerel Fisheries Restrictions 6 Table 6 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND... THE EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt. 679, Table 6 Table 6 to Part 679—Steller Sea Lion...

  15. 50 CFR Table 6 to Part 679 - Steller Sea Lion Protection Areas Atka Mackerel Fisheries Restrictions

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Steller Sea Lion Protection Areas Atka Mackerel Fisheries Restrictions 6 Table 6 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND... THE EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt. 679, Table 6 Table 6 to Part 679—Steller Sea Lion...

  16. 50 CFR Table 6 to Part 679 - Steller Sea Lion Protection Areas Atka Mackerel Fisheries Restrictions

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Steller Sea Lion Protection Areas Atka Mackerel Fisheries Restrictions 6 Table 6 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND... THE EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt. 679, Table 6 Table 6 to Part 679—Steller Sea Lion...

  17. 50 CFR Table 6 to Part 679 - Steller Sea Lion Protection Areas Atka Mackerel Fisheries Restrictions

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Steller Sea Lion Protection Areas Atka Mackerel Fisheries Restrictions 6 Table 6 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND... THE EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt. 679, Table 6 Table 6 to Part 679—Steller Sea Lion...

  18. 50 CFR Table 6 to Part 679 - Steller Sea Lion Protection Areas Atka Mackerel Fisheries Restrictions

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Steller Sea Lion Protection Areas Atka Mackerel Fisheries Restrictions 6 Table 6 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND... THE EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt. 679, Table 6 Table 6 to Part 679—Steller Sea Lion...

  19. 50 CFR Table 5 to Part 679 - Steller Sea Lion Protection Areas Pacific Cod Fisheries Restrictions

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Steller Sea Lion Protection Areas Pacific Cod Fisheries Restrictions 5 Table 5 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OF THE EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt....

  20. 50 CFR Table 5 to Part 679 - Steller Sea Lion Protection Areas Pacific Cod Fisheries Restrictions

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Steller Sea Lion Protection Areas Pacific Cod Fisheries Restrictions 5 Table 5 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OF THE EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt....

  1. 50 CFR Table 5 to Part 679 - Steller Sea Lion Protection Areas Pacific Cod Fisheries Restrictions

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Steller Sea Lion Protection Areas Pacific Cod Fisheries Restrictions 5 Table 5 to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OF THE EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt....

  2. 33 CFR 334.760 - Naval Support Activity Panama City and Alligator Bayou, a tributary of St. Andrew Bay, Fla...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... City and Alligator Bayou, a tributary of St. Andrew Bay, Fla.; naval restricted area. 334.760 Section... DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.760 Naval Support Activity Panama City and... permission from the Officer in Charge, Naval Support Activity Panama City, Panama City Beach, Florida, or his...

  3. 33 CFR 334.760 - Naval Support Activity Panama City and Alligator Bayou, a tributary of St. Andrew Bay, Fla...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... City and Alligator Bayou, a tributary of St. Andrew Bay, Fla.; naval restricted area. 334.760 Section... DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.760 Naval Support Activity Panama City and... permission from the Officer in Charge, Naval Support Activity Panama City, Panama City Beach, Florida, or his...

  4. Myocarditis in auto-immune or auto-inflammatory diseases.

    PubMed

    Comarmond, Cloé; Cacoub, Patrice

    2017-08-01

    Myocarditis is a major cause of heart disease in young patients and a common precursor of heart failure due to dilated cardiomyopathy. Some auto-immune and/or auto-inflammatory diseases may be accompanied by myocarditis, such as sarcoidosis, Behçet's disease, eosinophilic granulomatosis with polyangiitis, myositis, and systemic lupus erythematosus. However, data concerning myocarditis in such auto-immune and/or auto-inflammatory diseases are sparse. New therapeutic strategies should better target the modulation of the immune system, depending on the phase of the disease and the type of underlying auto-immune and/or auto-inflammatory disease. Copyright © 2017 Elsevier B.V. All rights reserved.

  5. Land Cover Change Monitoring of Typical Functional Communities of Sichuan Province Based on ZY-3 Data

    NASA Astrophysics Data System (ADS)

    Li, G. M.; Li, S.; Ying, G. W.; Wu, X. P.

    2018-04-01

    According to the function, land space types are divided into key development areas, restricted development areas and forbidden development areas in Sichuan Province. This paper monitors and analyses the changes of land cover in different typical functional areas from 2010 to 2017, which based on ZY-3 high-score images data and combined with statistical yearbook and thematic data of Sichuan Province. The results show that: The land cover types of typical key development zones are mainly composed of cultivated land, forest land, garden land, and housing construction land, which accounts for the total area of land cover 87 %. The land cover types of typical restricted development zone mainly consists of forest land and grassland, which occupy 97.71 % of the total area of the surface coverage. The land cover types of the typical prohibition development zone mainly consist of forest land, grassland, desert and bared earth, which accounts for the total area of land cover 99.31 %.

  6. Continuous Monitoring of Essential Tremor Using a Portable System Based on Smartwatch.

    PubMed

    Zheng, Xiaochen; Vieira Campos, Alba; Ordieres-Meré, Joaquín; Balseiro, Jose; Labrador Marcos, Sergio; Aladro, Yolanda

    2017-01-01

    Essential tremor (ET) shows amplitude fluctuations throughout the day, presenting challenges in both clinical and treatment monitoring. Tremor severity is currently evaluated by validated rating scales, which only provide a timely and subjective assessment during a clinical visit. Motor sensors have shown favorable performances in quantifying tremor objectively. A new highly portable system was used to monitor tremor continuously during daily lives. It consists of a smartwatch with a triaxial accelerometer, a smartphone, and a remote server. An experiment was conducted involving eight ET patients. The average effective data collection time per patient was 26 (±6.05) hours. Fahn-Tolosa-Marin Tremor Rating Scale (FTMTRS) was adopted as the gold standard to classify tremor and to validate the performance of the system. Quantitative analysis of tremor severity on different time scales is validated. Significant correlations were observed between neurologist's FTMTRS and patient's FTMTRS auto-assessment scores ( r  = 0.84; p  = 0.009), between the device quantitative measures and the scores from the standardized assessments of neurologists ( r  = 0.80; p  = 0.005) and patient's auto-evaluation ( r  = 0.97; p  = 0.032), and between patient's FTMTRS auto-assessment scores day-to-day ( r  = 0.87; p  < 0.001). A graphical representation of four patients with different degrees of tremor was presented, and a representative system is proposed to summarize the tremor scoring at different time scales. This study demonstrates the feasibility of prolonged and continuous monitoring of tremor severity during daily activities by a highly portable non-restrictive system, a useful tool to analyze efficacy and effectiveness of treatment.

  7. 76 FR 38570 - Safety Zone; Fourth of July Fireworks Event, Pagan River, Smithfield, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-01

    .... ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a 420-foot radius safety zone on..., vessel traffic will be temporarily restricted within 420 feet of the fireworks launch site. Discussion of... the area bounded by a 420-foot radius circle centered on position 36[deg]59'18'' N/076[deg]37'45'' W...

  8. 75 FR 34372 - Safety Zone; Fourth of July Fireworks Event, Pagan River, Smithfield, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    .... ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a 420-foot radius safety zone on... other debris, vessel traffic will be temporarily restricted within 420 feet of the fireworks launch site... within the area bounded by a 420-foot radius circle centered on position 36[deg]59'18'' N/076[deg]37'45...

  9. 75 FR 54026 - Safety Zone; Red Bull Flugtag, Delaware River, Camden, NJ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... Franklin Bridge. The safety zone will restrict vessel traffic from a portion of the Delaware River [email protected] . If you have questions on viewing the docket, call Renee V. Wright, Program Manager... from vessels and vessels from any debris in the water as a result from the event. Under 5 U.S.C. 553(d...

  10. The transition from riparian to upland forest plant communities on headwater streams in the southern Sierra Nevada, California, United States

    Treesearch

    Christopher R. Dolanc; Carolyn T. Hunsaker

    2017-01-01

    Abstract. Fixed-width buffer zones on rivers and streams are designed to protect the diverse riparian community and its important function in the ecosystem. However, recent data suggest that riparian areas of some western forests have become more fire prone because of restrictions on fuel reduction treatments within buffer zones....

  11. 76 FR 38013 - Safety Zone; Big Sioux River From the Military Road Bridge North Sioux City to the Confluence of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... rising flood water. Operation in this zone is restricted unless specifically authorized by the Captain of... rising flood water. The impacts on routine navigation are expected to be minimal. Small Entities Under... vessels from destruction, loss or injury due to the hazards associated with rising flood water. If you are...

  12. The role of permafrost and seasonal frost in the hydrology of northern wetlands in North America

    USGS Publications Warehouse

    Woo, M.-K.; Winter, Thomas C.

    1993-01-01

    Wetlands are a common landscape feature in the Arctic, Subarctic, and north Temperate zones of North America. In all three-zones, the occurrnce of seasonal frost results in similar surface-water processes in the early spring. For example, surface ice and snow generally melt before the soil frost thaws, causing melt water to flow into depressions, over the land surface and at times, across low topographic divides. However, evapotranspiration and ground-water movement differ among the three climatic zones because they are more affected by permafrost than seasonal frost. The water source for plants in the Arctic is restricted to the small volume of subsurface water lying above the permafrost. Although this is also true in the Subarctic where permafrost exists, where it does not, plants may receive and possibly reflect, more regional ground-water sources. Where permafrost exists, the interaction of wetlands with subsurface water is largely restricted to shallow local flow systems. But where permafrost is absent in parts of the Subarctic and all of the Temperature zone, wetlands may have a complex interaction with ground-water-flow systems of all magnitudes.

  13. Medicare Part D Roulette: Potential Implications of Random Assignment and Plan Restrictions

    PubMed Central

    Patel, Rajul A.; Walberg, Mark P.; Woelfel, Joseph A.; Amaral, Michelle M.; Varu, Paresh

    2013-01-01

    Background Dual-eligible (Medicare/Medicaid) beneficiaries are randomly assigned to a benchmark plan, which provides prescription drug coverage under the Part D benefit without consideration of their prescription drug profile. To date, the potential for beneficiary assignment to a plan with poor formulary coverage has been minimally studied and the resultant financial impact to beneficiaries unknown. Objective We sought to determine cost variability and drug use restrictions under each available 2010 California benchmark plan. Methods Dual-eligible beneficiaries were provided Part D plan assistance during the 2010 annual election period. The Medicare Web site was used to determine benchmark plan costs and prescription utilization restrictions for each of the six California benchmark plans available for random assignment in 2010. A standardized survey was used to record all de-identified beneficiary demographic and plan specific data. For each low-income subsidy-recipient (n = 113), cost, rank, number of non-formulary medications, and prescription utilization restrictions were recorded for each available 2010 California benchmark plan. Formulary matching rates (percent of beneficiary's medications on plan formulary) were calculated for each benchmark plan. Results Auto-assigned beneficiaries had only a 34% chance of being assigned to the lowest cost plan; the remainder faced potentially significant avoidable out-of-pocket costs. Wide variations between benchmark plans were observed for plan cost, formulary coverage, formulary matching rates, and prescription utilization restrictions. Conclusions Beneficiaries had a 66% chance of being assigned to a sub-optimal plan; thereby, they faced significant avoidable out-of-pocket costs. Alternative methods of beneficiary assignment could decrease beneficiary and Medicare costs while also reducing medication non-compliance. PMID:24753963

  14. Forecasting daily meteorological time series using ARIMA and regression models

    NASA Astrophysics Data System (ADS)

    Murat, Małgorzata; Malinowska, Iwona; Gos, Magdalena; Krzyszczak, Jaromir

    2018-04-01

    The daily air temperature and precipitation time series recorded between January 1, 1980 and December 31, 2010 in four European sites (Jokioinen, Dikopshof, Lleida and Lublin) from different climatic zones were modeled and forecasted. In our forecasting we used the methods of the Box-Jenkins and Holt- Winters seasonal auto regressive integrated moving-average, the autoregressive integrated moving-average with external regressors in the form of Fourier terms and the time series regression, including trend and seasonality components methodology with R software. It was demonstrated that obtained models are able to capture the dynamics of the time series data and to produce sensible forecasts.

  15. Implementing Safety Measures

    EPA Pesticide Factsheets

    Required risk mitigation measures for soil fumigants protect handlers, applicators, and bystanders from pesticide exposure. Measures include buffer zones, sign posting, good agricultural practices, restricted use pesticide classification, and FMPs.

  16. 78 FR 20277 - Safety Zones & Special Local Regulations; Recurring Marine Events in Captain of the Port Long...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-04

    ...The Coast Guard proposes to add, delete, and modify safety zones and special local regulations and add language to clarify time frames and notification requirements for annual marine events in the Sector Long Island Sound Captain of the Port (COTP) Zone. When these regulated areas are activated and subject to enforcement, this rule would restrict vessels from portions of water areas during these recurring events. The safety zones and special local regulations will facilitate public notification of events and provide protective measures for the maritime public and event participants from the hazards associated with these recurring events.

  17. Molecular species delimitation and its implications for species descriptions using desmosomatid and nannoniscid isopods from the VEMA fracture zone as example taxa

    NASA Astrophysics Data System (ADS)

    Brix, Saskia; Bober, Simon; Tschesche, Claudia; Kihara, Terue-Cristina; Driskell, Amy; Jennings, Robert M.

    2018-02-01

    We found 72 species for COI and 45 for 16 S by species delimitation among 186 (from 195 extracted) desmosomatid (144) and nannoniscid (42) sequenced specimens of a total of > 400 specimens for both families. Multiple "discovery"-type species delimitation methods were used, so that consistency across methods could be assessed: The ABGD analysis detected a barcode gap of 3-6% for COI and 4-6% for 16 S, in the whole dataset. Most putative species have a horizontally limited distribution along the Vema fracture zone, although the details depend in part on the interpretation of species delimitation analyses. Putative species were mostly restricted to the eastern or western Vema fracture zone, with only eight crossing the complete Vema fracture zone. Our data suggest that even robustly-sampled species exhibited small ranges; the range estimates calculable from present data were around 500 km, and three were on the order of 1000-2500 km. We chose an abundant, but geographically restricted species (Eugerdella egoni Tschesche and Brix sp. nov.) collected at a single site in the Vema transform fault, and two species (Prochelator barnacki Bober and Brix sp. nov. and Whoia sockei Brix and Kihara sp. nov.) with a broad, but disjunct distribution in the Vema fracture zone for taxonomic description.

  18. Development situation and prospecting division of geothermal resources in Yangshan county, Guangdong Province

    NASA Astrophysics Data System (ADS)

    Yin, Lijun; Luo, Yizhen; Ma, Huiying; Xie, Yanxiao; Liu, Zhenzhen

    2017-03-01

    Yangshan County has abundant low-geothermal resources in its northeast, southwest, and midwest regions. These low-temperature geothermal resources in Yangshan County can prove to be beneficial for different purposes such as tourism, recuperation, sauna, and agriculture. Thirteen geothermal hot springs (spots) and seven geothermal anomalies have been discovered till now in this area. The geothermal resources are grouped on the basis of their conditions as follows: The Chengjia-Dianzhan and Dongguan-Jietan geothermal areas are classified as priority development zones, the Huangben-Mazishui and Qigongyuntankeng areas as sub-priority development zones, the Jiangying geothermal area as a general development zone, the Yangshan geothermal area as a potential development zone, and the Chengjia and Longfeng geothermal areas as restricted development zones.

  19. Influence of laser beam incidence angle on laser lap welding quality of galvanized steels

    NASA Astrophysics Data System (ADS)

    Mei, Lifang; Yan, Dongbing; Chen, Genyu; Wang, Zhenhui; Chen, Shuixuan

    2017-11-01

    Based on the characteristics of laser welded structural parts of auto bodies, the influence of variation in laser beam incidence angle on the lap welding performance of galvanized auto-body sheets was studied. Lap welding tests were carried out on the galvanized sheets for auto-body application at different laser beam incidence angles by using the optimal welding parameters obtained through orthogonal experiment. The effects of incidence angle variation on seam appearance, cross-sectional shape, joint mechanical properties and microstructure of weldments were analyzed. In addition, the main factors influencing the value of incidence angle were investigated. According to the results, the weld seams had a good appearance as well as a fine, and uniform microstructure when the laser beam incidence angle was smaller than the critical incidence angle, and thus they could withstand great tensile and shear loads. Moreover, all tensile-shear specimens were fractured in the base material zone. When the laser beam incidence angle was larger than the critical incidence angle, defects like shrinkage and collapse tended to emerge, thereby resulting in the deteriorated weldability of specimens. Meanwhile, factors like the type and thickness of sheet, weld width as well as inter-sheet gap all had a certain effect on the value of laser beam incidence angle. When the sheet thickness was small and the weld width was narrow, the laser beam incidence angle could be increased appropriately. At the same time, small changes in the inter-sheet gap could greatly impact the value of incidence angle. When the inter-sheet gap was small, the laser beam incidence angle should not be too large.

  20. FRACOR-software toolbox for deterministic mapping of fracture corridors in oil fields on AutoCAD platform

    NASA Astrophysics Data System (ADS)

    Ozkaya, Sait I.

    2018-03-01

    Fracture corridors are interconnected large fractures in a narrow sub vertical tabular array, which usually traverse entire reservoir vertically and extended for several hundreds of meters laterally. Fracture corridors with their huge conductivities constitute an important element of many fractured reservoirs. Unlike small diffuse fractures, actual fracture corridors must be mapped deterministically for simulation or field development purposes. Fracture corridors can be identified and quantified definitely with borehole image logs and well testing. However, there are rarely sufficient image logs or well tests, and it is necessary to utilize various fracture corridor indicators with varying degrees of reliability. Integration of data from many different sources, in turn, requires a platform with powerful editing and layering capability. Available commercial reservoir characterization software packages, with layering and editing capabilities, can be cost intensive. CAD packages are far more affordable and may easily acquire the versatility and power of commercial software packages with addition of a small software toolbox. The objective of this communication is to present FRACOR, a software toolbox which enables deterministic 2D fracture corridor mapping and modeling on AutoCAD platform. The FRACOR toolbox is written in AutoLISPand contains several independent routines to import and integrate available fracture corridor data from an oil field, and export results as text files. The resulting fracture corridor maps consists mainly of fracture corridors with different confidence levels from combination of static and dynamic data and exclusion zones where no fracture corridor can exist. The exported text file of fracture corridors from FRACOR can be imported into an upscaling programs to generate fracture grid for dual porosity simulation or used for field development and well planning.

  1. Production de faisceaux EPR à l'aide d'un oscillateur paramétrique optique à auto-verrouillage de phase

    NASA Astrophysics Data System (ADS)

    Longchambon, L.; Laurat, J.; Treps, N.; Ducci, S.; Maître, A.; Coudreau, T.; Fabre, C.

    2002-06-01

    Nous étudions théoriquement les propriétés quantiques des faisceaux lumineux continus orthogonalement polarisés émis par un Oscillateur Paramétrique Optique (OPO) de type II contenant une lame biréfringente. Quand les axes optiques de la lame sont tournés par rapport à ceux du cristal paramétrique, un couplage apparaît entre les faisceaux signal et complémentaire qui entraîne un verrouillage de phase entre les deux modes et un fonctionnement à dégénérescence de fréquence à l'intérieur d'une zone d'accrochage. Les corrélations quantiques entre les deux faisceaux permettent de définir les zones dans l'espace des paramètres expérimentaux où les différents critères associés à l'intrication EPR utilisés en information quantique sont vérifiés.

  2. Comparisons of fully automated syphilis tests with conventional VDRL and FTA-ABS tests.

    PubMed

    Choi, Seung Jun; Park, Yongjung; Lee, Eun Young; Kim, Sinyoung; Kim, Hyon-Suk

    2013-06-01

    Serologic tests are widely used for the diagnosis of syphilis. However, conventional methods require well-trained technicians to produce reliable results. We compared automated nontreponemal and treponemal tests with conventional methods. The HiSens Auto Rapid Plasma Reagin (AutoRPR) and Treponema Pallidum particle agglutination (AutoTPPA) tests, which utilize latex turbidimetric immunoassay, were assessed. A total of 504 sera were assayed by AutoRPR, AutoTPPA, conventional VDRL and FTA-ABS. Among them, 250 samples were also tested by conventional TPPA. The concordance rate between the results of VDRL and AutoRPR was 67.5%, and 164 discrepant cases were all VDRL reactive but AutoRPR negative. In the 164 cases, 133 showed FTA-ABS reactivity. Medical records of 106 among the 133 cases were reviewed, and 82 among 106 specimens were found to be collected from patients already treated for syphilis. The concordance rate between the results of AutoTPPA and FTA-ABS was 97.8%. The results of conventional TPPA and AutoTPPA for 250 samples were concordant in 241 cases (96.4%). AutoRPR showed higher specificity than that of VDRL, while VDRL demonstrated higher sensitivity than that of AutoRPR regardless of whether the patients had been already treated for syphilis or not. Both FTA-ABS and AutoTPPA showed high sensitivities and specificities greater than 98.0%. Automated RPR and TPPA tests could be alternatives to conventional syphilis tests, and AutoRPR would be particularly suitable in treatment monitoring, since results by AutoRPR in cases after treatment became negative more rapidly than by VDRL. Copyright © 2013. Published by Elsevier Inc.

  3. 33 CFR 334.240 - Potomac River, Mattawoman Creek and Chicamuxen Creek; U.S. Naval Surface Weapons Center, Indian...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Potomac River, Mattawoman Creek..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.240 Potomac River, Mattawoman Creek...) The danger zone. Beginning at a point on the easterly shore of the Potomac River at latitude 38°36′00...

  4. 33 CFR 334.240 - Potomac River, Mattawoman Creek and Chicamuxen Creek; U.S. Naval Surface Weapons Center, Indian...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Potomac River, Mattawoman Creek..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.240 Potomac River, Mattawoman Creek...) The danger zone. Beginning at a point on the easterly shore of the Potomac River at latitude 38°36′00...

  5. 33 CFR 334.240 - Potomac River, Mattawoman Creek and Chicamuxen Creek; U.S. Naval Surface Weapons Center, Indian...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Potomac River, Mattawoman Creek..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.240 Potomac River, Mattawoman Creek...) The danger zone. Beginning at a point on the easterly shore of the Potomac River at latitude 38°36′00...

  6. 33 CFR 334.240 - Potomac River, Mattawoman Creek and Chicamuxen Creek; U.S. Naval Surface Weapons Center, Indian...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Potomac River, Mattawoman Creek..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.240 Potomac River, Mattawoman Creek...) The danger zone. Beginning at a point on the easterly shore of the Potomac River at latitude 38°36′00...

  7. 33 CFR 334.240 - Potomac River, Mattawoman Creek and Chicamuxen Creek; U.S. Naval Surface Weapons Center, Indian...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Potomac River, Mattawoman Creek..., DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.240 Potomac River, Mattawoman Creek...) The danger zone. Beginning at a point on the easterly shore of the Potomac River at latitude 38°36′00...

  8. 75 FR 34927 - Safety Zone; Parade of Ships, Seattle SeaFair Fleet Week, Pier 66, Elliott Bay, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-21

    ...-AA00 Safety Zone; Parade of Ships, Seattle SeaFair Fleet Week, Pier 66, Elliott Bay, WA AGENCY: Coast... Seattle SeaFair Fleet Week. This action is intended to restrict vessel traffic movement and entry into... of Ships for the annual Seattle SeaFair Fleet Week. For the purposes of this rule the Parade of Ships...

  9. 78 FR 42733 - Safety Zone; Cleveland Dragon Boat Festival and Head of the Cuyahoga, Cuyahoga River, Cleveland, OH

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-17

    ...-AA00 Safety Zone; Cleveland Dragon Boat Festival and Head of the Cuyahoga, Cuyahoga River, Cleveland... intended to restrict vessels from a portion of the Cuyahoga River during the Dragon Boat Festival and Head... over a decade and the Dragon Boat Festival for the last 7 years. In response to past years' events, the...

  10. Stem cells in Nanomia bijuga (Siphonophora), a colonial animal with localized growth zones.

    PubMed

    Siebert, Stefan; Goetz, Freya E; Church, Samuel H; Bhattacharyya, Pathikrit; Zapata, Felipe; Haddock, Steven H D; Dunn, Casey W

    2015-01-01

    Siphonophores (Hydrozoa) have unparalleled colony-level complexity, precision of colony organization, and functional specialization between zooids (i.e., the units that make up colonies). Previous work has shown that, unlike other colonial animals, most growth in siphonophores is restricted to one or two well-defined growth zones that are the sites of both elongation and zooid budding. It remained unknown, however, how this unique colony growth and development is realized at the cellular level. To understand the colony-level growth and development of siphonophores at the cellular level, we characterize the distribution of proliferating cells and interstitial stem cells (i-cells) in the siphonophore Nanomia bijuga. Within the colony, we find evidence that i-cells are present at the tip of the horn, the structure within the growth zone that gives rise to new zooids. Co-localized gene expression of vasa-1, pl10, piwi, nanos-1, and nanos-2 suggests that i-cells persist in the youngest zooid buds and that i-cells become progressively restricted to specific regions within the zooids until they are mostly absent from the oldest zooids. The examined genes remain expressed in gametogenic regions. No evidence for i-cells is found in the stem between maturing zooids. Domains of high cell proliferation include regions where the examined genes are expressed, but also include some areas in which the examined genes were not expressed such as the stem within the growth zones. Cell proliferation in regions devoid of vasa-1, pl10, piwi, nanos-1, and nanos-2 expression indicates the presence of mitotically active epithelial cell lineages and, potentially, progenitor cell populations. We provide the first evidence for i-cells in a siphonophore. Our findings suggest maintenance of i-cell populations at the sites of growth zones and that these sites are the main source of i-cells. This restriction of stem cells to particular regions in the colony, in combination with localized budding and spatial patterning during pro-bud subdivision, may play a major role in facilitating the precision of siphonophore growth. Spatially restricted maintenance of i-cells in mature zooids and absence of i-cells along the stem may explain the reduced developmental plasticity in older parts of the colony.

  11. Criterion-Referenced Test Items for Auto Body.

    ERIC Educational Resources Information Center

    Tannehill, Dana, Ed.

    This test item bank on auto body repair contains criterion-referenced test questions based upon competencies found in the Missouri Auto Body Competency Profile. Some test items are keyed for multiple competencies. The tests cover the following 26 competency areas in the auto body curriculum: auto body careers; measuring and mixing; tools and…

  12. Beyond the classic thermoneutral zone

    PubMed Central

    Kingma, Boris RM; Frijns, Arjan JH; Schellen, Lisje; van Marken Lichtenbelt, Wouter D

    2014-01-01

    The thermoneutral zone is defined as the range of ambient temperatures where the body can maintain its core temperature solely through regulating dry heat loss, i.e., skin blood flow. A living body can only maintain its core temperature when heat production and heat loss are balanced. That means that heat transport from body core to skin must equal heat transport from skin to the environment. This study focuses on what combinations of core and skin temperature satisfy the biophysical requirements of being in the thermoneutral zone for humans. Moreover, consequences are considered of changes in insulation and adding restrictions such as thermal comfort (i.e. driver for thermal behavior). A biophysical model was developed that calculates heat transport within a body, taking into account metabolic heat production, tissue insulation, and heat distribution by blood flow and equates that to heat loss to the environment, considering skin temperature, ambient temperature and other physical parameters. The biophysical analysis shows that the steady-state ambient temperature range associated with the thermoneutral zone does not guarantee that the body is in thermal balance at basal metabolic rate per se. Instead, depending on the combination of core temperature, mean skin temperature and ambient temperature, the body may require significant increases in heat production or heat loss to maintain stable core temperature. Therefore, the definition of the thermoneutral zone might need to be reformulated. Furthermore, after adding restrictions on skin temperature for thermal comfort, the ambient temperature range associated with thermal comfort is smaller than the thermoneutral zone. This, assuming animals seek thermal comfort, suggests that thermal behavior may be initiated already before the boundaries of the thermoneutral zone are reached. PMID:27583296

  13. Beyond the classic thermoneutral zone: Including thermal comfort.

    PubMed

    Kingma, Boris Rm; Frijns, Arjan Jh; Schellen, Lisje; van Marken Lichtenbelt, Wouter D

    2014-01-01

    The thermoneutral zone is defined as the range of ambient temperatures where the body can maintain its core temperature solely through regulating dry heat loss, i.e., skin blood flow. A living body can only maintain its core temperature when heat production and heat loss are balanced. That means that heat transport from body core to skin must equal heat transport from skin to the environment. This study focuses on what combinations of core and skin temperature satisfy the biophysical requirements of being in the thermoneutral zone for humans. Moreover, consequences are considered of changes in insulation and adding restrictions such as thermal comfort (i.e. driver for thermal behavior). A biophysical model was developed that calculates heat transport within a body, taking into account metabolic heat production, tissue insulation, and heat distribution by blood flow and equates that to heat loss to the environment, considering skin temperature, ambient temperature and other physical parameters. The biophysical analysis shows that the steady-state ambient temperature range associated with the thermoneutral zone does not guarantee that the body is in thermal balance at basal metabolic rate per se. Instead, depending on the combination of core temperature, mean skin temperature and ambient temperature, the body may require significant increases in heat production or heat loss to maintain stable core temperature. Therefore, the definition of the thermoneutral zone might need to be reformulated. Furthermore, after adding restrictions on skin temperature for thermal comfort, the ambient temperature range associated with thermal comfort is smaller than the thermoneutral zone. This, assuming animals seek thermal comfort, suggests that thermal behavior may be initiated already before the boundaries of the thermoneutral zone are reached.

  14. Necessary Conditions for Intraplate Seismic Zones in North America

    NASA Astrophysics Data System (ADS)

    Thomas, William A.; Powell, Christine A.

    2017-12-01

    The cause of intraplate seismic zones persists as an important scientific and societal question. Most intraplate earthquakes are concentrated in specific seismic zones along or adjacent to large-scale basement structures (e.g., rifts or sutures at ancient plate boundaries) within continental crust. The major intraplate seismic zones are limited to specific segments and are not distributed along the lengths of the ancient structures. We present a new hypothesis that major intraplate seismic zones are restricted to places where concentrated crustal deformation (CCD) is overprinted on large-scale basement structures. Examples where CCD affects the stability of specific parts of large-scale structures in response to present-day stress conditions include the most active seismic zones in central and eastern North America: Charlevoix, Eastern Tennessee, and New Madrid. Our hypothesis has important implications for the assessment of seismic hazards.

  15. 33 CFR 334.770 - Gulf of Mexico and St. Andrew Sound, south of East Bay, Fla., Tyndall Drone Launch Corridor...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Gulf of Mexico and St. Andrew... ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.770 Gulf of Mexico and St....; restricted area. (a) The area. The waters of the Gulf of Mexico and St. Andrew Sound within an area described...

  16. 33 CFR 334.770 - Gulf of Mexico and St. Andrew Sound, south of East Bay, Fla., Tyndall Drone Launch Corridor...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Gulf of Mexico and St. Andrew... ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.770 Gulf of Mexico and St....; restricted area. (a) The area. The waters of the Gulf of Mexico and St. Andrew Sound within an area described...

  17. 33 CFR 334.770 - Gulf of Mexico and St. Andrew Sound, south of East Bay, Fla., Tyndall Drone Launch Corridor...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Gulf of Mexico and St. Andrew... ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.770 Gulf of Mexico and St....; restricted area. (a) The area. The waters of the Gulf of Mexico and St. Andrew Sound within an area described...

  18. 33 CFR 334.770 - Gulf of Mexico and St. Andrew Sound, south of East Bay, Fla., Tyndall Drone Launch Corridor...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Gulf of Mexico and St. Andrew... ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.770 Gulf of Mexico and St....; restricted area. (a) The area. The waters of the Gulf of Mexico and St. Andrew Sound within an area described...

  19. 33 CFR 334.770 - Gulf of Mexico and St. Andrew Sound, south of East Bay, Fla., Tyndall Drone Launch Corridor...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Gulf of Mexico and St. Andrew... ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.770 Gulf of Mexico and St....; restricted area. (a) The area. The waters of the Gulf of Mexico and St. Andrew Sound within an area described...

  20. Water Relations and Gas Exchange of Loblolly Pine Seedlings Under Different Cultural Practices on Poorly Drained Sites in Arkansas

    Treesearch

    Mohd S. Rahman; Michael G. Messina; Richard F. Fisher

    2002-01-01

    Substantial forest acreage in the south-central U.S. is seasonally water-logged due to an underlying fragipan. Severely restricted drainage in the non-growing season leads to a reduced subsoil zone, which restricts root respiration. The same sites may also be subjected to summer drought. These climatic and edaphic problems may result in low seedling survival and...

  1. [Joint application of 7 interventional pulmonology methods in early diagnosis of lung cancer].

    PubMed

    Jin, Fa-Guang; Li, Wang-Ping; Mu, De-Guang; Chu, Dong-Ling; Fu, En-Qing; Xie, Yong-Hong; Lu, Jing-Li; Sun, Ya-Ni

    2009-06-23

    To evaluate the combination of 7 interventional pulmonology methods in early diagnosis of lung cancer. A total of 467 patients with thoracic and pulmonary lesions (include hilum pulmonis lymphadenectasis, mediastinal lymphadenectasis, pulmonary scobination, lump, lamellar infiltration, small amount of pleural fluid and pleural scobination) had negative results via exfoliative cytology, bacteriology and routine bronchoscopy. All these patients had ultrathin bronchoscopy with biopsy and brushing. For those 155 cases whose foci were located at porta pulmonis, inner zone or median zone, the authors applied ultrathin bronchoscopy with biopsy and brushing guided by X-ray. For those 95 cases whose foci were located at median zone or outer zone and unconnected with chest wall, per cutem lung puncture needle aspiration was employed under the guidance of X-ray. For those 102 cases whose foci were tightly connected with pleural membrane, per cutem lung puncture biopsy was employed under the guidance of type-B ultrasonic. For those 59 cases with suspected central airway foci, auto-fluorescence bronchoscopic biopsy and brushing were employed. For those 67 cases with hilum pulmonis or mediastinal lymphadenectasis, endobronchial ultrasonic transbronchial needle aspiration (EBUS-TBNA) was employed. For those 23 cases with small amount of pleural fluid or pleural scobination, electronic thoracoscopic biopsy and brushing were employed. It was found that 118 cases were diagnosed by ultrathin bronchoscopic biopsy and brushing with a positive rate of 25.3% (118/467), 105 cases by ultrathin bronchoscopy with biopsy and brushing guided by X-ray with a positive rate of 67.7% (105/155), 63 cases by per cutem lung puncture needle aspiration under the guidance of X-ray with a positive rate of 66.3% (63/95), 69 cases by per cutem lung puncture biopsy under the guidance of type-B ultrasound with a positive rate of 67.6% (69/102), 18 cases by auto-fluorescence bronchoscopic biopsy and brushing with a positive rate of 35.3% (18/51), 52 cases by EBUS-TBNA with a positive rate of 77.6% (52/67), 12 cases by electronic thoracoscopic biopsy and brushing with a positive rate of 52.2% (12/23). The total positive diagnostic rate was 93.6% (437/467). And the diagnostic rate of < or = stage II lung cancer (3 cases carcinoma in situ, 84 stage I a, 63 stage Ib, 65 stage IIa and 44 stage IIb) was 82.7% (259/313). Joint application of these 7 interventional bronchoscopic techniques can significantly boost the rate of early diagnosis of lung cancer.

  2. Automotive Mechanics as Applied to Auto Body; Auto Body Repair and Refinishing 3: 9037.02.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    This is a course in which the student will receive the general information, technical knowledge, basic skills, attitudes, and values required for job entry level as an auto body repair helper. Course content includes general and specific goals, orientation, instruction in service tools and bench skills, and auto mechanics as applied to auto body.…

  3. The performance of two automatic servo-ventilation devices in the treatment of central sleep apnea.

    PubMed

    Javaheri, Shahrokh; Goetting, Mark G; Khayat, Rami; Wylie, Paul E; Goodwin, James L; Parthasarathy, Sairam

    2011-12-01

    This study was conducted to evaluate the therapeutic performance of a new auto Servo Ventilation device (Philips Respironics autoSV Advanced) for the treatment of complex central sleep apnea (CompSA). The features of autoSV Advanced include an automatic expiratory pressure (EPAP) adjustment, an advanced algorithm for distinguishing open versus obstructed airway apnea, a modified auto backup rate which is proportional to subject's baseline breathing rate, and a variable inspiratory support. Our primary aim was to compare the performance of the advanced servo-ventilator (BiPAP autoSV Advanced) with conventional servo-ventilator (BiPAP autoSV) in treating central sleep apnea (CSA). A prospective, multicenter, randomized, controlled trial. Five sleep laboratories in the United States. Thirty-seven participants were included. All subjects had full night polysomnography (PSG) followed by a second night continuous positive airway pressure (CPAP) titration. All had a central apnea index ≥ 5 per hour of sleep on CPAP. Subjects were randomly assigned to 2 full-night PSGs while treated with either the previously marketed autoSV, or the new autoSV Advanced device. The 2 randomized sleep studies were blindly scored centrally. Across the 4 nights (PSG, CPAP, autoSV, and autoSV Advanced), the mean ± 1 SD apnea hypopnea indices were 53 ± 23, 35 ± 20, 10 ± 10, and 6 ± 6, respectively; indices for CSA were 16 ± 19, 19 ± 18, 3 ± 4, and 0.6 ± 1. AutoSV Advanced was more effective than other modes in correcting sleep related breathing disorders. BiPAP autoSV Advanced was more effective than conventional BiPAP autoSV in the treatment of sleep disordered breathing in patients with CSA.

  4. 33 CFR 334.220 - Chesapeake Bay, south of Tangier Island, Va.; naval firing range.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.220 Chesapeake Bay, south of Tangier Island, Va.; naval firing range. (a) The danger zone. Beginning... to latitude 37°45′00″, longitude 76°09′48″; thence to latitude 37°45′00″, longitude 76°08′51″; and...

  5. 33 CFR 334.220 - Chesapeake Bay, south of Tangier Island, Va.; naval firing range.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.220 Chesapeake Bay, south of Tangier Island, Va.; naval firing range. (a) The danger zone. Beginning... to latitude 37°45′00″, longitude 76°09′48″; thence to latitude 37°45′00″, longitude 76°08′51″; and...

  6. 33 CFR 334.220 - Chesapeake Bay, south of Tangier Island, Va.; naval firing range.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.220 Chesapeake Bay, south of Tangier Island, Va.; naval firing range. (a) The danger zone. Beginning... to latitude 37°45′00″, longitude 76°09′48″; thence to latitude 37°45′00″, longitude 76°08′51″; and...

  7. 33 CFR 334.220 - Chesapeake Bay, south of Tangier Island, Va.; naval firing range.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.220 Chesapeake Bay, south of Tangier Island, Va.; naval firing range. (a) The danger zone. Beginning... to latitude 37°45′00″, longitude 76°09′48″; thence to latitude 37°45′00″, longitude 76°08′51″; and...

  8. 33 CFR 334.220 - Chesapeake Bay, south of Tangier Island, Va.; naval firing range.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.220 Chesapeake Bay, south of Tangier Island, Va.; naval firing range. (a) The danger zone. Beginning... to latitude 37°45′00″, longitude 76°09′48″; thence to latitude 37°45′00″, longitude 76°08′51″; and...

  9. Department of the Navy Explosives Safety Site Approval Process Improvement Initiative

    DTIC Science & Technology

    2010-07-01

    All applicable existing land-use restrictions, such as explosives safety quantity distance (ESQD) arcs, Hazards of Electromagnetic Radiation to... Ordnance ( HERO ) zones, air field safety zones, and munitions response program sites are noted in the ESAR.  PWO will have in place a written...N547) Naval Ordnance Safety and Security Activity Farragut Hall, 3817 Strauss Ave, Suite 108 Indian Head, MD 20640-5151 (301) 744-6059

  10. 75 FR 38718 - Safety Zone; Sault Sainte Marie 4th of July Fireworks, St. Mary's River, Sault Sainte Marie, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-06

    ...-AA00 Safety Zone; Sault Sainte Marie 4th of July Fireworks, St. Mary's River, Sault Sainte Marie, MI... restrict vessels from a portion of the St. Mary's River during the Sault Sainte Marie 4th of July Fireworks... the setup and launching of fireworks in conjunction with the Sault Sainte Marie 4th of July Fireworks...

  11. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Buce, W.F.

    Heretofore methods of preventing lost circulation in a formation zone during drilling operations, for example, involve pumping loss circulation material into the zone. These materials were wedged into the pores and indices of the formation with fluid pressure. In large pathways, these methods were often unsuccessful owing to the fact that the material could not be maintained at their desired location. By this method, a polymerizable material capable of forming hard, porous relatively insoluble popcorn polymers is placed in the formation zone desired to be sealed. The material is there maintained under polymerization conditions for a time sufficient to polymerizemore » in situ at least a portion of the material and restrict fluid pathways through the zone without exerting a force on the formation zone of a magnitude sufficient for fracturing it. (10 claims)« less

  12. 45 CFR 12.3 - General policies.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... with State or local zoning restrictions, building codes, or similar limitations. (e) Organizations...-exempt under section 501(c)(3) of the Internal Revenue Code of 1954. (c) Real property will be requested...

  13. 45 CFR 12.3 - General policies.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... with State or local zoning restrictions, building codes, or similar limitations. (e) Organizations...-exempt under section 501(c)(3) of the Internal Revenue Code of 1954. (c) Real property will be requested...

  14. 45 CFR 12.3 - General policies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... with State or local zoning restrictions, building codes, or similar limitations. (e) Organizations...-exempt under section 501(c)(3) of the Internal Revenue Code of 1954. (c) Real property will be requested...

  15. 45 CFR 12.3 - General policies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... with State or local zoning restrictions, building codes, or similar limitations. (e) Organizations...-exempt under section 501(c)(3) of the Internal Revenue Code of 1954. (c) Real property will be requested...

  16. AUTO_DERIV: Tool for automatic differentiation of a Fortran code

    NASA Astrophysics Data System (ADS)

    Stamatiadis, S.; Farantos, S. C.

    2010-10-01

    AUTO_DERIV is a module comprised of a set of FORTRAN 95 procedures which can be used to calculate the first and second partial derivatives (mixed or not) of any continuous function with many independent variables. The mathematical function should be expressed as one or more FORTRAN 77/90/95 procedures. A new type of variables is defined and the overloading mechanism of functions and operators provided by the FORTRAN 95 language is extensively used to define the differentiation rules. Proper (standard complying) handling of floating-point exceptions is provided by using the IEEE_EXCEPTIONS intrinsic module (Technical Report 15580, incorporated in FORTRAN 2003). New version program summaryProgram title: AUTO_DERIV Catalogue identifier: ADLS_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADLS_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 2963 No. of bytes in distributed program, including test data, etc.: 10 314 Distribution format: tar.gz Programming language: Fortran 95 + (optionally) TR-15580 (Floating-point exception handling) Computer: all platforms with a Fortran 95 compiler Operating system: Linux, Windows, MacOS Classification: 4.12, 6.2 Catalogue identifier of previous version: ADLS_v1_0 Journal reference of previous version: Comput. Phys. Comm. 127 (2000) 343 Does the new version supersede the previous version?: Yes Nature of problem: The need to calculate accurate derivatives of a multivariate function frequently arises in computational physics and chemistry. The most versatile approach to evaluate them by a computer, automatically and to machine precision, is via user-defined types and operator overloading. AUTO_DERIV is a Fortran 95 implementation of them, designed to evaluate the first and second derivatives of a function of many variables. Solution method: The mathematical rules for differentiation of sums, products, quotients, elementary functions in conjunction with the chain rule for compound functions are applied. The function should be expressed as one or more Fortran 77/90/95 procedures. A new type of variables is defined and the overloading mechanism of functions and operators provided by the Fortran 95 language is extensively used to implement the differentiation rules. Reasons for new version: The new version supports Fortran 95, handles properly the floating-point exceptions, and is faster due to internal reorganization. All discovered bugs are fixed. Summary of revisions:The code was rewritten extensively to benefit from features introduced in Fortran 95. Additionally, there was a major internal reorganization of the code, resulting in faster execution. The user interface described in the original paper was not changed. The values that the user must or should specify before compilation (essentially, the number of independent variables) were moved into ad_types module. There were many minor bug fixes. One important bug was found and fixed; the code did not handle correctly the overloading of ∗ in aλ when a=0. The case of division by zero and the discontinuity of the function at the requested point are indicated by standard IEEE exceptions ( IEEE_DIVIDE_BY_ZERO and IEEE_INVALID respectively). If the compiler does not support IEEE exceptions, a module with the appropriate name is provided, imitating the behavior of the 'standard' module in the sense that it raises the corresponding exceptions. It is up to the compiler (through certain flags probably) to detect them. Restrictions: None imposed by the program. There are certain limitations that may appear mostly due to the specific implementation chosen in the user code. They can always be overcome by recoding parts of the routines developed by the user or by modifying AUTO_DERIV according to specific instructions given in [1]. The common restrictions of available memory and the capabilities of the compiler are the same as the original version. Additional comments: The program has been tested using the following compilers: Intel ifort, GNU gfortran, NAGWare f95, g95. Running time: The typical running time for the program depends on the compiler and the complexity of the differentiated function. A rough estimate is that AUTO_DERIV is ten times slower than the evaluation of the analytical ('by hand') function value and derivatives (if they are available). References:S. Stamatiadis, R. Prosmiti, S.C. Farantos, AUTO_DERIV: tool for automatic differentiation of a Fortran code, Comput. Phys. Comm. 127 (2000) 343.

  17. Multiplicity counting from fission detector signals with time delay effects

    NASA Astrophysics Data System (ADS)

    Nagy, L.; Pázsit, I.; Pál, L.

    2018-03-01

    In recent work, we have developed the theory of using the first three auto- and joint central moments of the currents of up to three fission chambers to extract the singles, doubles and triples count rates of traditional multiplicity counting (Pázsit and Pál, 2016; Pázsit et al., 2016). The objective is to elaborate a method for determining the fissile mass, neutron multiplication, and (α, n) neutron emission rate of an unknown assembly of fissile material from the statistics of the fission chamber signals, analogous to the traditional multiplicity counting methods with detectors in the pulse mode. Such a method would be an alternative to He-3 detector systems, which would be free from the dead time problems that would be encountered in high counting rate applications, for example the assay of spent nuclear fuel. A significant restriction of our previous work was that all neutrons born in a source event (spontaneous fission) were assumed to be detected simultaneously, which is not fulfilled in reality. In the present work, this restriction is eliminated, by assuming an independent, identically distributed random time delay for all neutrons arising from one source event. Expressions are derived for the same auto- and joint central moments of the detector current(s) as in the previous case, expressed with the singles, doubles, and triples (S, D and T) count rates. It is shown that if the time-dispersion of neutron detections is of the same order of magnitude as the detector pulse width, as they typically are in measurements of fast neutrons, the multiplicity rates can still be extracted from the moments of the detector current, although with more involved calibration factors. The presented formulae, and hence also the performance of the proposed method, are tested by both analytical models of the time delay as well as with numerical simulations. Methods are suggested also for the modification of the method for large time delay effects (for thermalised neutrons).

  18. The influence of four macrozoobenthic species on the abundance of the amphipod Corophium volutator on tidal flats of the Wadden Sea

    NASA Astrophysics Data System (ADS)

    Flach, E. C.

    On the tidal flats of the Wadden Sea, a zonation pattern can be found with Corophium volutator and Nereis diversicolor as the dominating species of the upper intertidal zone and Arenicola marina and Cerastoderma edule as the dominating species of the lower zone. As C. volutator can live under a great variety of physical conditions, its restriction to higher areas might result from biotic interactions. This was investigated by field experiments on a tidal flat in the westernmost part of the Wadden Sea. Within large depopulated areas, small plots were recolonized with different densities of N. diversicolor, A. marina, C. edule and Macoma balthica and the subsequent settlement and dynamics of C. volutator were studied. In addition, A. marina and/or C. edule were added to or removed from small plots within a natural benthic community. Neither the presence of M. balthica not that of N. diversicolor significantly affected the abundance of C. volutator. A strongly negative effect was found of C. edule when present in high densities, whereas A. marina negatively affected C. volutator abundance already at relatively low densities. Local removals of A. marina and C. edule from their own zone resulted in increases of Corophium numbers at these locations and local additions of these species within the Corophium zone resulted in decreases of Corophium numbers at these locations. It is suggested that the major species to restrict C. volutator effectively to the upper tidal zone is A. marina.

  19. Fusion competent synaptic vesicles persist upon active zone disruption and loss of vesicle docking

    PubMed Central

    Wang, Shan Shan H.; Held, Richard G.; Wong, Man Yan; Liu, Changliang; Karakhanyan, Aziz; Kaeser, Pascal S.

    2016-01-01

    In a nerve terminal, synaptic vesicle docking and release are restricted to an active zone. The active zone is a protein scaffold that is attached to the presynaptic plasma membrane and opposed to postsynaptic receptors. Here, we generated conditional knockout mice removing the active zone proteins RIM and ELKS, which additionally led to loss of Munc13, Bassoon, Piccolo, and RIM-BP, indicating disassembly of the active zone. We observed a near complete lack of synaptic vesicle docking and a strong reduction in vesicular release probability and the speed of exocytosis, but total vesicle numbers, SNARE protein levels, and postsynaptic densities remained unaffected. Despite loss of the priming proteins Munc13 and RIM and of docked vesicles, a pool of releasable vesicles remained. Thus, the active zone is necessary for synaptic vesicle docking and to enhance release probability, but releasable vesicles can be localized distant from the presynaptic plasma membrane. PMID:27537483

  20. [Assessment on the ecological suitability in Zhuhai City, Guangdong, China, based on minimum cumulative resistance model].

    PubMed

    Li, Jian-fei; Li, Lin; Guo, Luo; Du, Shi-hong

    2016-01-01

    Urban landscape has the characteristics of spatial heterogeneity. Because the expansion process of urban constructive or ecological land has different resistance values, the land unit stimulates and promotes the expansion of ecological land with different intensity. To compare the effect of promoting and hindering functions in the same land unit, we firstly compared the minimum cumulative resistance value of promoting and hindering functions, and then looked for the balance of two landscape processes under the same standard. According to the ecology principle of minimum limit factor, taking the minimum cumulative resistance analysis method under two expansion processes as the evaluation method of urban land ecological suitability, this research took Zhuhai City as the study area to estimate urban ecological suitability by relative evaluation method with remote sensing image, field survey, and statistics data. With the support of ArcGIS, five types of indicators on landscape types, ecological value, soil erosion sensitivity, sensitivity of geological disasters, and ecological function were selected as input parameters in the minimum cumulative resistance model to compute urban ecological suitability. The results showed that the ecological suitability of the whole Zhuhai City was divided into five levels: constructive expansion prohibited zone (10.1%), constructive expansion restricted zone (32.9%), key construction zone (36.3%), priority development zone (2.3%), and basic cropland (18.4%). Ecological suitability of the central area of Zhuhai City was divided into four levels: constructive expansion prohibited zone (11.6%), constructive expansion restricted zone (25.6%), key construction zone (52.4%), priority development zone (10.4%). Finally, we put forward the sustainable development framework of Zhuhai City according to the research conclusion. On one hand, the government should strictly control the development of the urban center area. On the other hand, the secondary urban center area such as Junchang and Doumen need improve the public infrastructure to relieve the imbalance between eastern and western development in Zhuhai City.

  1. Improved cutback method measuring beat-length for high-birefringence optical fiber by fitting data of photoelectric signal

    NASA Astrophysics Data System (ADS)

    Shi, Zhi-Dong; Lin, Jian-Qiang; Bao, Huan-Huan; Liu, Shu; Xiang, Xue-Nong

    2008-03-01

    A photoelectric measurement system for measuring the beat length of birefringence fiber is set up including a set of rotating-wave-plate polarimeter using single photodiode. And two improved cutback methods suitable for measuring beat-length within millimeter range of high birefringence fiber are proposed through data processing technique. The cut length needs not to be restricted shorter than one centimeter so that the auto-cleaving machine is freely used, and no need to carefully operate the manually cleaving blade with low efficiency and poor success. The first method adopts the parameter-fitting to a saw-tooth function of tried beat length by the criterion of minimum square deviations, without special limitation on the cut length. The second method adopts linear-fitting in the divided length ranges, only restrict condition is the increment between different cut lengths less than one beat-length. For a section of holey high-birefringence fiber, we do experiments respectively by the two methods. The detecting error of beat-length is discussed and the advantage is compared.

  2. Sequential monitoring and stability of ex vivo-expanded autologous and non-autologous regulatory T cells following infusion in non-human primates

    PubMed Central

    Zhang, H.; Guo, H.; Lu, L.; Zahorchak, A. F.; Wiseman, R. W.; Raimondi, G.; Cooper, D. K. C.; Ezzelarab, M. B.; Thomson, A. W.

    2016-01-01

    Ex vivo-expanded cynomolgus monkey CD4+CD25+CD127− regulatory T cells (Treg) maintained Foxp3 demethylation status at the Treg-Specific Demethylation Region (TSDR), and potently suppressed T cell proliferation through 3 rounds of expansion. When CFSE- or VPD450-labeled autologous (auto) and non-autologous (non-auto) expanded Treg were infused into monkeys, the number of labeled auto-Treg in peripheral blood declined rapidly during the first week, but persisted at low levels in both normal and anti-thymocyte globulin plus rapamycin-treated (immunosuppressed; IS) animals for at least 3 weeks. By contrast, MHC-mismatched non-auto-Treg could not be detected in normal monkey blood or in blood of two out of the three IS monkeys by day 6 post-infusion. They were also more difficult to detect than auto-Treg in peripheral lymphoid tissue. Both auto- and non-auto-Treg maintained Ki67 expression early after infusion. Sequential monitoring revealed that adoptively-transferred auto-Treg maintained similarly high levels of Foxp3 and CD25 and low CD127 compared with endogenous Treg, although Foxp3 staining diminished over time in these non-transplanted recipients. Thus, infused ex vivo-expanded auto-Treg persist longer than MHC-mismatched non-auto-Treg in blood of non-human primates and can be detected in secondary lymphoid tissue. Host lymphodepletion and rapamycin administration did not consistently prolong the persistence of non-auto-Treg in these sites. PMID:25783759

  3. Economic evaluation of epinephrine auto-injectors for peanut allergy.

    PubMed

    Shaker, Marcus; Bean, Katherine; Verdi, Marylee

    2017-08-01

    Three commercial epinephrine auto-injectors were available in the United States in the summer of 2016: EpiPen, Adrenaclick, and epinephrine injection, USP auto-injector. To describe the variation in pharmacy costs among epinephrine auto-injector devices in New England and evaluate the additional expense associated with incremental auto-injector costs. Decision analysis software was used to evaluate costs of the most and least expensive epinephrine auto-injector devices for children with peanut allergy. To evaluate regional variation in epinephrine auto-injector costs, a random sample of New England national and corporate pharmacies was compared with a convenience sample of pharmacies from 10 Canadian provinces. Assuming prescriptions written for 2 double epinephrine packs each year (home and school), the mean costs of food allergy over the 20-year model horizon totaled $58,667 (95% confidence interval [CI] $57,745-$59,588) when EpiPen was prescribed and $45,588 (95% CI $44,873-$46,304) when epinephrine injection, USP auto-injector was prescribed. No effectiveness differences were evident between groups, with 17.19 (95% CI 17.11-17.27) quality-adjusted life years accruing for each subject. The incremental cost per episode of anaphylaxis treated with epinephrine over the model horizon was $12,576 for EpiPen vs epinephrine injection, USP auto-injector. EpiPen costs were lowest at Canadian pharmacies ($96, 95% CI $85-$107). There was price consistency between corporate and independent pharmacies throughout New England by device brand, with the epinephrine injection, USP auto-injector being the most affordable device. Cost differences among epinephrine auto-injectors were significant. More expensive auto-injector brands did not appear to provide incremental benefit. Copyright © 2017 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  4. Unintentional Epinephrine Auto-injector Injuries: A National Poison Center Observational Study.

    PubMed

    Anshien, Marco; Rose, S Rutherfoord; Wills, Brandon K

    2016-11-24

    Epinephrine is the only first-line therapeutic agent used to treat life-threatening anaphylaxis. Epinephrine auto-injectors are commonly carried by patients at risk for anaphylaxis, and reported cases of unintentional auto-injector injury have increased over the last decade. Modifications of existing designs and release of a new style of auto-injector are intended to reduce epinephrine auto-injector misuse. The aim of the study was to characterize reported cases of unintentional epinephrine auto-injector exposures from 2013 to 2014 and compare demographics, auto-injector model, and anatomical site of such exposures. The American Association of Poison Control Center's National Poison Data System was searched from January 1, 2013, to December 31, 2014, for cases of unintentional epinephrine auto-injector exposures. Anatomical site data were obtained from all cases reported to the Virginia Poison Center and participating regional poison center for Auvi-Q cases. A total of 6806 cases of unintentional epinephrine auto-injector exposures were reported to US Poison Centers in 2013 and 2014. Of these cases, 3933 occurred with EpiPen, 2829 with EpiPen Jr, 44 with Auvi-Q, and no case reported of Adrenaclick. The most common site of unintentional injection for traditional epinephrine auto-injectors was the digit or thumb, with 58% of cases for EpiPen and 39% of cases with EpiPen Jr. With Auvi-Q, the most common site was the leg (78% of cases). The number of unintentional epinephrine auto-injector cases reported to American Poison Centers in 2013-2014 has increased compared with previous data. Most EpiPen exposures were in the digits, whereas Auvi-Q was most frequently in the leg. Because of the limitations of Poison Center data, more research is needed to identify incidence of unintentional exposures and the effectiveness of epinephrine auto-injector redesign.

  5. Evaluation of strategies for the eradication of Pseudorabies virus (Aujeszky's disease) in commercial swine farms in Chiang-Mai and Lampoon Provinces, Thailand, using a simulation disease spread model.

    PubMed

    Ketusing, N; Reeves, A; Portacci, K; Yano, T; Olea-Popelka, F; Keefe, T; Salman, M

    2014-04-01

    Several strategies for eradicating Pseudorabies virus (Aujeszky's disease) in Chiang-Mai and Lampoon Provinces, Thailand, were compared using a computer simulation model, the North American Animal Disease Spread Model (NAADSM). The duration of the outbreak, the number of affected herds and the number of destroyed herds were compared during these simulated outbreaks. Depopulation, zoning for restricted movement and improved detection and vaccination strategies were assessed. The most effective strategies to eradicate Pseudorabies as per the findings from this study are applying depopulation strategies with MOVEMENT RESTRICTIONS in 3-, 8- and 16-km ZONES surrounding infected herds and enhancing the eradication with vaccination campaign on 16-km radius surrounding infected herds. © 2012 Blackwell Verlag GmbH.

  6. Research on remote sensing image pixel attribute data acquisition method in AutoCAD

    NASA Astrophysics Data System (ADS)

    Liu, Xiaoyang; Sun, Guangtong; Liu, Jun; Liu, Hui

    2013-07-01

    The remote sensing image has been widely used in AutoCAD, but AutoCAD lack of the function of remote sensing image processing. In the paper, ObjectARX was used for the secondary development tool, combined with the Image Engine SDK to realize remote sensing image pixel attribute data acquisition in AutoCAD, which provides critical technical support for AutoCAD environment remote sensing image processing algorithms.

  7. Monogenic Auto-inflammatory Syndromes: A Review of the Literature.

    PubMed

    Azizi, Gholamreza; Khadem Azarian, Shahin; Nazeri, Sepideh; Mosayebian, Ali; Ghiasy, Saleh; Sadri, Ghazal; Mohebi, Ali; Khan Nazer, Nikoo Hossein; Afraei, Sanaz; Mirshafiey, Abbas

    2016-12-01

    Auto-inflammatory syndromes are a new group of distinct hereditable disorders characterized by episodes of seemingly unprovoked inflammation (most commonly in skin, joints, gut, and eye), the absence of a high titer of auto-antibodies or auto-reactive T cells, and an inborn error of innate immunity. A narrative literature review was carried out of studies related to auto-inflammatory syndromes to discuss the pathogenesis and clinical manifestation of these syndromes. This review showed that the main monogenic auto-inflammatory syndromes are familial Mediterranean fever (FMF), mevalonate kinase deficiency (MKD), Blau syndrome, TNF receptor-associated periodic syndrome (TRAPS), cryopyrin-associated periodic syndrome (CAPS), and pyogenic arthritis with pyoderma gangrenosum and acne (PAPA). The data suggest that correct diagnosis and treatment of monogenic auto-inflammatory diseases relies on the physicians' awareness. Therefore, understanding of the underlying pathogenic mechanisms of auto-inflammatory syndromes, and especially the fact that these disorders are mediated by IL-1 secretion stimulated by monocytes and macrophages, facilitated significant progress in patient management.

  8. Feedback circuit design of an auto-gating power supply for low-light-level image intensifier

    NASA Astrophysics Data System (ADS)

    Yang, Ye; Yan, Bo; Zhi, Qiang; Ni, Xiao-bing; Li, Jun-guo; Wang, Yu; Yao, Ze

    2015-11-01

    This paper introduces the basic principle of auto-gating power supply which using a hybrid automatic brightness control scheme. By the analysis of current as image intensifier to special requirements of auto-gating power supply, a feedback circuit of the auto-gating power supply is analyzed. Find out the reason of the screen flash after the auto-gating power supply assembled image intensifier. This paper designed a feedback circuit which can shorten the response time of auto-gating power supply and improve screen slight flicker phenomenon which the human eye can distinguish under the high intensity of illumination.

  9. 47 CFR 80.307 - Compulsory use of radiotelegraph auto alarm.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Compulsory use of radiotelegraph auto alarm. 80.307 Section 80.307 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL... Safety Watches § 80.307 Compulsory use of radiotelegraph auto alarm. The radiotelegraph auto alarm...

  10. 47 CFR 80.307 - Compulsory use of radiotelegraph auto alarm.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Compulsory use of radiotelegraph auto alarm. 80.307 Section 80.307 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL... Safety Watches § 80.307 Compulsory use of radiotelegraph auto alarm. The radiotelegraph auto alarm...

  11. 47 CFR 80.307 - Compulsory use of radiotelegraph auto alarm.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Compulsory use of radiotelegraph auto alarm. 80.307 Section 80.307 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL... Safety Watches § 80.307 Compulsory use of radiotelegraph auto alarm. The radiotelegraph auto alarm...

  12. 47 CFR 80.307 - Compulsory use of radiotelegraph auto alarm.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Compulsory use of radiotelegraph auto alarm. 80.307 Section 80.307 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL... Safety Watches § 80.307 Compulsory use of radiotelegraph auto alarm. The radiotelegraph auto alarm...

  13. 47 CFR 80.307 - Compulsory use of radiotelegraph auto alarm.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Compulsory use of radiotelegraph auto alarm. 80.307 Section 80.307 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL... Safety Watches § 80.307 Compulsory use of radiotelegraph auto alarm. The radiotelegraph auto alarm...

  14. Enhancing Price Response Programs through Auto-DR: California's 2007 Implementation Experience

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kiliccote, Sila; Wikler, Greg; Chiu, Albert

    2007-12-18

    This paper describes automated demand response (Auto-DR) activities, an innovative effort in California to ensure that DR programs produce effective and sustainable impacts. Through the application of automation and communication technologies coupled with well-designed incentives and DR programs such as Critical Peak Pricing (CPP) and Demand Bidding (DBP), Auto-DR is opening up the opportunity for many different types of buildings to effectively participate in DR programs. We present the results of Auto-DR implementation efforts by the three California investor-owned utilities for the Summer of 2007. The presentation emphasizes Pacific Gas and Electric Company's (PG&E) Auto-DR efforts, which represents the largestmore » in the state. PG&E's goal was to recruit, install, test and operate 15 megawatts of Auto-DR system capability. We describe the unique delivery approaches, including optimizing the utility incentive structures designed to foster an Auto-DR service provider community. We also show how PG&E's Critical Peak Pricing (CPP) and Demand Bidding (DBP) options were called and executed under the automation platform. Finally, we show the results of the Auto-DR systems installed and operational during 2007, which surpassed PG&E's Auto-DR goals. Auto-DR is being implemented by a multi-disciplinary team including the California Investor Owned Utilities (IOUs), energy consultants, energy management control system vendors, the Lawrence Berkeley National Laboratory (LBNL), and the California Energy Commission (CEC).« less

  15. On the mechanism of the ring zone effect obtained with the mixed haemadsorption technique

    PubMed Central

    Jonsson, J.; Fagraeus, Astrid

    1969-01-01

    A ring zone effect noted with the radial diffusion disc test modification of the mixed haemadsorption technique has been studied using human anti-thyroid sera reacting with thyroid monolayer cultures. Results are presented which suggest that the `empty' centre of the ring zones is due to an excess of attached antibody. Sera giving the ring zone effect contain a larger number of antibody specificities than those producing filled zones. The appearance of ring zones is favoured by a low density of antigens on the culture. These findings and a number of synergistic effects produced by mixing ring and filled zone reactions are compatible with the hypothesis that the ring zone is produced when several antibodies of different specificities react with restricted antigenic areas carrying densely located clusters of antigenic determinants representing the different specificities contained in the ring zone sera. The crowding of antibodies on the clusters in the centre of the ring zones creates a steric hindrance for the indicator cells so that they are not firmly attached in this area. The antibody zone is therefore indicated as a peripheral haemadsorption ring. ImagesFIG. 1FIG. 2FIG. 4FIG. 6FIG. 7FIG. 9 PMID:5307718

  16. Female Infertility and Serum Auto-antibodies: a Systematic Review.

    PubMed

    Deroux, Alban; Dumestre-Perard, Chantal; Dunand-Faure, Camille; Bouillet, Laurence; Hoffmann, Pascale

    2017-08-01

    On average, 10 % of infertile couples have unexplained infertility. Auto-immune disease (systemic lupus erythematosus, anti-phospholipid syndrome) accounts for a part of these cases. In the last 20 years, aspecific auto-immunity, defined as positivity of auto-antibodies in blood sample without clinical or biological criteria for defined diseases, has been evoked in a subpopulation of infertile women. A systematic review was performed (PUBMED) using the MESH search terms "infertility" and "auto-immunity" or "reproductive technique" or "assisted reproduction" or "in vitro fertilization" and "auto-immunity." We retained clinical and physiopathological studies that were applicable to the clinician in assuming joint management of both infertility associated with serum auto-antibodies in women. Thyroid auto-immunity which affects thyroid function could be a cause of infertility; even in euthyroidia, the presence of anti-thyroperoxydase antibodies and/or thyroglobulin are related to infertility. The presence of anti-phospholipid (APL) and/or anti-nuclear (ANA) antibodies seems to be more frequent in the population of infertile women; serum auto-antibodies are associated with early ovarian failure, itself responsible for fertility disorders. However, there exist few publications on this topic. The methods of dosage, as well as the clinical criteria of unexplained infertility deserve to be standardized to allow a precise response to the question of the role of serum auto-antibodies in these women. The direct pathogenesis of this auto-immunity is unknown, but therapeutic immunomodulators, prescribed on a case-by-case basis, could favor pregnancy even in cases of unexplained primary or secondary infertility.

  17. Effects of Granular Control on Customers’ Perspective and Behavior with Automated Demand Response Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schetrit, Oren; Kim, Joyce; Yin, Rongxin

    2014-08-01

    Automated demand response (Auto-DR) is expected to close the loop between buildings and the grid by providing machine-to-machine communications to curtail loads without the need for human intervention. Hence, it can offer more reliable and repeatable demand response results to the grid than the manual approach and make demand response participation a hassle-free experience for customers. However, many building operators misunderstand Auto-DR and are afraid of losing control over their building operation. To ease the transition from manual to Auto-DR, we designed and implemented granular control of Auto-DR systems so that building operators could modify or opt out of individualmore » load-shed strategies whenever they wanted. This paper reports the research findings from this effort demonstrated through a field study in large commercial buildings located in New York City. We focused on (1) understanding how providing granular control affects building operators’ perspective on Auto-DR, and (2) evaluating the usefulness of granular control by examining their interaction with the Auto-DR user interface during test events. Through trend log analysis, interviews, and surveys, we found that: (1) the opt-out capability during Auto-DR events can remove the feeling of being forced into load curtailments and increase their willingness to adopt Auto-DR; (2) being able to modify individual load-shed strategies allows flexible Auto-DR participation that meets the building’s changing operational requirements; (3) a clear display of automation strategies helps building operators easily identify how Auto-DR is functioning and can build trust in Auto-DR systems.« less

  18. Administration of the adrenaline auto-injector at the nursery/kindergarten/school in Western Japan.

    PubMed

    Korematsu, Seigo; Fujitaka, Michiko; Ogata, Mika; Zaitsu, Masafumi; Motomura, Chikako; Kuzume, Kazuyo; Toku, Yuchiro; Ikeda, Masanori; Odajima, Hiroshi

    2017-01-01

    In view of the increasing prevalence of food allergies, there has been an associated increase in frequency of situations requiring an emergency response for anaphylaxis at the home, childcare facilities and educational institutions. To clarify the situation of adrenaline auto-injector administration in nursery/kindergarten/school, we carried out a questionnaire survey on pediatric physicians in Western Japan. In 2015, self-reported questionnaires were mailed to 421 physicians who are members of the West Japan Research Society Pediatric Clinical Allergy and Shikoku Research Society Pediatric Clinical Allergy. The response rate was 44% (185 physicians) where 160 physicians had a prescription registration for the adrenaline auto-injector. In the past year, 1,330 patients were prescribed the adrenaline auto-injector where 83 patients (6% of the prescribed patients) actually administered the adrenaline auto-injector, of which 14 patients (17% of the administered patients) self-administered the adrenaline auto-injector. "Guardians" at the nursery/kindergarten and elementary school were found to have administered the adrenaline auto-injector the most. Among 117 adrenaline auto-injector prescription-registered physicians, 79% had experienced nonadministration of adrenaline auto-injector at nursery/kindergarten/school when anaphylaxis has occurred. The most frequent reason cited for not administering the adrenaline auto-injector was "hesitation about the timing of administration." If the adrenaline auto-injector was administered after the guardian arrived at the nursery/kindergarten/school, it may lead to delayed treatment of anaphylaxis in which symptoms develop in minutes. Education and cooperation among physicians and nursery/kindergarten/school staff will reduce the number of children suffering unfortunate outcomes due to anaphylaxis.

  19. V-TECS Guide for Auto Body Repair.

    ERIC Educational Resources Information Center

    Gregory, Margaret R.; Benson, Robert T.

    This curriculum guide consists of materials for teaching a course in auto body repair. Addressed in the individual units of the guide are the following topics: the nature and scope of auto body repair; safety; tools; auto body construction; simple metal straightening; welding; painting and refinishing; refinishing complete lacquer; refinishing…

  20. Conversations with AutoTutor Help Students Learn

    ERIC Educational Resources Information Center

    Graesser, Arthur C.

    2016-01-01

    AutoTutor helps students learn by holding a conversation in natural language. AutoTutor is adaptive to the learners' actions, verbal contributions, and in some systems their emotions. Many of AutoTutor's conversation patterns simulate human tutoring, but other patterns implement ideal pedagogies that open the door to computer tutors eclipsing…

  1. Potential Interventions by Government and Industry to Minimize Violations of Temporary Flight Restrictions

    NASA Technical Reports Server (NTRS)

    Zuschlag, Michael

    2005-01-01

    This document enumerates interventions to reduce the frequency of restricted airspace violations, particularly those associated with temporary flight restrictions (TFRs) and air defense identification zones (ADIZs), by more effectively providing pilots with the information necessary to avoid such violations. Interventions are divided into both near term and far term groupings. Short term interventions, some variants of which are already in progress focus on improving the form and content of the textual Notices to Airmen (NOTAMs) as well as the graphical depiction of TFRs. A long-term technical intervention is proposed which would provide pilots the following functionality: ground and airborne presentation of information on any restricted airspace, including display on an electronic moving map, fully mechanized execution from the cockpit of the procedures required for entry into restricted airspaces that allow for entry, and alerting of the potential for TFR violations both during flight planning and while the aircraft is moving.

  2. TRIM5α requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription

    PubMed Central

    Fletcher, Adam J; Christensen, Devin E; Nelson, Chad; Tan, Choon Ping; Schaller, Torsten; Lehner, Paul J; Sundquist, Wesley I; Towers, Greg J

    2015-01-01

    TRIM5α is an antiviral, cytoplasmic, E3 ubiquitin (Ub) ligase that assembles on incoming retroviral capsids and induces their premature dissociation. It inhibits reverse transcription of the viral genome and can also synthesize unanchored polyubiquitin (polyUb) chains to stimulate innate immune responses. Here, we show that TRIM5α employs the E2 Ub-conjugating enzyme Ube2W to anchor the Lys63-linked polyUb chains in a process of TRIM5α auto-ubiquitination. Chain anchoring is initiated, in cells and in vitro, through Ube2W-catalyzed monoubiquitination of TRIM5α. This modification serves as a substrate for the elongation of anchored Lys63-linked polyUb chains, catalyzed by the heterodimeric E2 enzyme Ube2N/Ube2V2. Ube2W targets multiple TRIM5α internal lysines with Ub especially lysines 45 and 50, rather than modifying the N-terminal amino group, which is instead αN-acetylated in cells. E2 depletion or Ub mutation inhibits TRIM5α ubiquitination in cells and restores restricted viral reverse transcription, but not infection. Our data indicate that the stepwise formation of anchored Lys63-linked polyUb is a critical early step in the TRIM5α restriction mechanism and identify the E2 Ub-conjugating cofactors involved. PMID:26101372

  3. Automatic Scaling of Digisonde Ionograms Test and Evaluation Report.

    DTIC Science & Technology

    1982-09-01

    Labrador 30 21 IManual MUF - Auto MUFj/Manual MUF April 1980 Goose Bay, Labrador 31 22 IManual MUF - Auto MUFI /Manual MUF July 1980 Goose Bay...Labrador 32 23 IManual MUF - Auto MUFI /Manual MUF September 1980 Goose Bay, Labrador 33 24 !Manual M(3000) - Auto M(3000)1 January 1980 Goose Bay, Labrador

  4. --No Title--

    Science.gov Websites

    ;height:auto;overflow:hidden}.poc_table .top_row{background-color:#eee;height:auto;overflow:hidden}.poc_table ;background-color:#FFF;height:auto;overflow:hidden;border-top:1px solid #ccc}.poc_table .main_row .name :200px;padding:5px;height:auto;overflow:hidden}.tli_grey_box{background-color:#eaeaea;text-align:center

  5. Paracontinuous boundaries within the Devonian Columbus Limestone and Delaware Formation of central Ohio

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Conkin, J.E.; Conkin, B.M.

    1994-04-01

    Internal units within the Columbus Limestone (Early Devonian Emsian [Schoharie] to Middle Devonian Eifelian [late Onesquethawan]) and the Delaware Formation (Middle Devonian early Givetian [Cazenovian]) of central Ohio are separated by disconformities of the magnitude of paracontinuities. Stauffer (1909) divided the Columbus Limestone into zones A--H and the Delaware Formation into zones I--M. Within the Columbus, the A Zone (conglomerate at the base of Bellepoint Member) disconformably overlies Late Silurian beds. The D zone at top of the Bellepoint Member (bearing the Kawkawlin Metabentonite horizon) is overlain paracontinuously by the Marblehead Member (Lower Paraspirifer acuminatus-Spirifer macrothyris to Brevispirifer gregarius-Moellerina greeneimore » zones [= E--G zones]), with the Onondagan Indian Nation Metabentonite in the top of the G Zone. The Marblehead Member is overlain paracontinuously by a bone bed at base of the Venice Member (H zone = Upper Paraspirifer acuminatus- Spirifer duodenarius'' Zone). I Zone (Dublin Shale=Marcellus) of the Delaware Formation overlies the Columbus and has two bone beds at its base; Tioga Metabentonite (restricted) overlies the I Zone bone beds and is a few tenths to 1.85 feet above the base of the I Zone. Paracontinuities and bone beds occur at the bases of J, K, and L zones. Conkin and Conkin (1975) have shown Stauffer's (1909) M Zone is an extension of his L Zone. The Olentangy paracontinuously overlies the L Zone.« less

  6. Clinical utility of anti-p53 auto-antibody: systematic review and focus on colorectal cancer.

    PubMed

    Suppiah, Aravind; Greenman, John

    2013-08-07

    Mutation of the p53 gene is a key event in the carcinogenesis of many different types of tumours. These can occur throughout the length of the p53 gene. Anti-p53 auto-antibodies are commonly produced in response to these p53 mutations. This review firstly describes the various mechanisms of p53 dysfunction and their association with subsequent carcinogenesis. Following this, the mechanisms of induction of anti-p53 auto-antibody production are shown, with various hypotheses for the discrepancies between the presence of p53 mutation and the presence/absence of anti-p53 auto-antibodies. A systematic review was performed with a descriptive summary of key findings of each anti-p53 auto-antibody study in all cancers published in the last 30 years. Using this, the cumulative frequency of anti-p53 auto-antibody in each cancer type is calculated and then compared with the incidence of p53 mutation in each cancer to provide the largest sample calculation and correlation between mutation and anti-p53 auto-antibody published to date. Finally, the review focuses on the data of anti-p53 auto-antibody in colorectal cancer studies, and discusses future strategies including the potentially promising role using anti-p53 auto-antibody presence in screening and surveillance.

  7. Auto-SCT improves survival in systemic light chain amyloidosis: a retrospective analysis with 14-year follow-up.

    PubMed

    Parmar, S; Kongtim, P; Champlin, R; Dinh, Y; Elgharably, Y; Wang, M; Bashir, Q; Shah, J J; Shah, N; Popat, U; Giralt, S A; Orlowski, R Z; Qazilbash, M H

    2014-08-01

    Optimal treatment approach continues to remain a challenge for systemic light chain amyloidosis (AL). So far, Auto-SCT is the only modality associated with long-term survival. However, failure to show survival benefit in randomized study raises questions regarding its efficacy. We present a comparative outcome analysis of Auto-SCT to conventional therapies (CTR) in AL patients treated over a 14-year period at our institution. Out of the 145 AL amyloidosis patients, Auto-SCT was performed in 80 patients with 1-year non-relapse mortality rate of 12.5%. Novel agents were used as part of induction therapy in 56% of transplant recipients vs 46% of CTR patients. Hematological and organ responses were seen in 74.6% and 39% in the Auto-SCT arm vs 53% and 12% in the CTR arm, respectively. The projected 5-year survival for Auto-SCT vs CTR was 63% vs 38%, respectively. Landmark analysis of patients alive at 1-year after diagnosis showed improved 5-year OS of 72% with Auto-SCT vs 65% in the CTR arm. In the multivariate analysis, age <60 years, induction therapy with novel agents, kidney only involvement and Auto-SCT were associated with improved survival. In conclusion, Auto-SCT is associated with long-term survival for patients with AL amyloidosis.

  8. [Psychosocial vulnerability and substance use screening during pregnancy: Evaluation of a composite auto-questionnaire versus usual medical questioning].

    PubMed

    Fline-Barthes, M-H; Vandendriessche, D; Gaugue, J; Urso, L; Therby, D; Subtil, D

    2015-05-01

    To evaluate auto-questionnaire use for psychosocial vulnerability and substance use (smoking, alcohol consumption, depression, intimate violence) screening during pregnancy versus usual medical report. An auto-questionnaire based on validated tests (Fagerström/HSI, T-ACE, EPDS, SSQ6) was proposed to 1977 pregnant patients at their first obstetrical consultation. We compared results of auto-questionnaire and usual medical questioning. The auto-questionnaire was filled by 1676 pregnant patients (89.4 %). The two Fagerström/HIS questions showed that 20.7 % smoked during pregnancy. T-ACE score was better than usual medical questioning to detect excessive alcohol consumption (4.0 % vs 0.1 %, P<0.05). Drug use before pregnancy was reported by 9.8 % patients in auto-questionnaire, but was only found in 4.9 % of medical files (P<0.001). Seven percent patients reported at least 3 depressive symptoms on 4 purposed in auto-questionnaire. Intimate violence, physical or psychological, was reported in 9.4 %. All of these vulnerability factors were linked together, in auto-questionnaire or in usual medical reports. Using auto-questionnaire based on standardized screening tests could help medical practioneers to detect psychosocial vulnerability and/or substance use during pregnancy. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  9. Long-term outcome of patients with multiple [corrected] myeloma-related advanced renal failure following auto-SCT.

    PubMed

    Glavey, S V; Gertz, M A; Dispenzieri, A; Kumar, S; Buadi, F; Lacy, M; Hayman, S R; Kapoor, P; Dingli, D; McCurdy, A; Hogan, W J; Gastineau, D A; Leung, N

    2013-11-01

    Renal failure commonly complicates multiple myeloma (MM) and is associated with reduced survival. It is not clear whether auto-SCT results in improved renal function or attainment of independence from dialysis in patients with advanced renal impairment due to MM. We conducted a retrospective cohort study of all patients who underwent auto-SCT for MM complicated by advanced renal failure at our institution over a 10-year period (2000-2010). We aimed to assess the association between auto-SCT and renal outcome in patients with serum creatinine (SCr) over 3 mg/dL, attributable to MM, including those who were dialysis dependent. Thirty patients (2.8% of all auto-SCT patients) met inclusion criteria. Fourteen of 15 patients who were dialysis dependent before auto-SCT remained dialysis dependent in the long term despite hematological response (HR). Of the remaining 15 patients with SCr >3 mg/dL, an improvement in glomerular filtration rate (GFR) from 15 to 19.4 mL/min/1.73 m(2) was noted post auto-SCT (P=0.035); however, neither HR post auto-SCT or pre-existing renal function were independently associated with renal outcome. Auto-SCT was not associated with independence from dialysis in patients with renal failure due to MM at our institution. Although auto-SCT was associated with an improvement in GFR in patients with SCr >3 mg/dL, this improvement was not related to HR.

  10. Infectious Complications during Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Children with High-Risk or Recurrent Solid Tumors

    PubMed Central

    Kang, Ji-Man; Lee, Ji Won; Yoo, Keon Hee; Kim, Yae-Jean; Sung, Ki Woong; Koo, Hong Hoe

    2016-01-01

    We retrospectively analyzed infectious complications during tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) in children and adolescents with high-risk or recurrent solid tumors. A total of 324 patients underwent their first HDCT/auto-SCT between October 2004 and September 2014, and 283 of them proceeded to their second HDCT/auto-SCT (a total of 607 HDCT/auto-SCTs). During the early transplant period of 607 HDCT/auto-SCTs (from the beginning of HDCT to day 30 post-transplant), bacteremia, urinary tract infection (UTI), respiratory virus infection, and varicella zoster virus (VZV) reactivation occurred in 7.1%, 2.3%, 13.0%, and 2.5% of HDCT/auto-SCTs, respectively. The early transplant period of the second HDCT/auto-SCT had infectious complications similar to the first HDCT/auto-SCT. During the late transplant period of HDCT/auto-SCT (from day 31 to 1 year post-transplant), bacteremia, UTI, and VZV reactivation occurred in 7.5%, 2.5%, and 3.9% of patients, respectively. Most infectious complications in the late transplant period occurred during the first 6 months post-transplant. There were no invasive fungal infections during the study period. Six patients died from infectious complications (4 from bacterial sepsis and 2 from respiratory virus infection). Our study suggests that infectious complications are similar following second and first HDCT/auto-SCT in children. PMID:27627440

  11. East Pacific rise at 21°N: the volcanic, tectonic, and hydrothermal processes of the central axis

    USGS Publications Warehouse

    Ballard, Richard D.; Francheteau, Jean; Juteau, Tierre; Rangan, Claude; Normark, William

    1981-01-01

    Photographs obtained by the ANGUS survey system at 21°N reveal many similarities to the geological processes delineated at other spreading centers and in particular those observed in the Galapagos Rift at 86°W. The region of recent volcanism is restricted to a narrow zone (Zone 1) approximately 1 km wide. This suggests that the width of the magma chamber feeding these flows is also narrow at the top. Variations in sediment cover are used to subdivide the flows within Zone 1 into three sheet-flow/pillow-flow pairs. The youngest pair appears to have erupted form a linear fissure 8 km long running parallel to the valley axis. This fissure is part of a larger en echelon pattern of eruptive fissures. Active hydrothermal vents associated with the youngest flows are situated directly above the apparent eruptive fissure. The high (350°C) temperature for some of the fluids exiting from the vents suggests a highly restricted circulation system involving, at times, little to no mixing with cold seawater. The lava terrain in the remainder of Zone 1 and bordering regions is characterized by extensive fracturing, further suggesting a narrow upper dimension to the magma chamber and also that subsurface hydrothermal deposition of massive sulfides may lead to a reduction in the mixing processes.

  12. East Pacific Rise at 21 °N: The volcanic, tectonic, and hydrothermal processes of the central axis

    USGS Publications Warehouse

    Ballard, Richard D.; Francheteau, Jean; Juteau, Tierre; Rangan, Claude; Normark, William R.

    1981-01-01

    Photographs obtained by the ANGUS survey system at 21°N reveal many similarities to the geological processes delineated at other spreading centers and in particular those observed in the Galapagos Rift at 86°W. The region of recent volcanism is restricted to a narrow zone (Zone l) approximately l km wide. This suggests that the width of the magma chamber feeding these flows is also narrow at the top. Variations in sediment cover are used to subdivide the flows within Zone 1 into three sheet-flow/pillow-flow pairs. The youngest pair appears to have erupted form a linear fissure 8 km long running parallel to the valley axis. This fissure is part of a larger en echelon pattern of eruptive fissures. Active hydrothermal vents associated with the youngest flows are situated directly above the apparent eruptive fissure. The high (350°C) temperature for some of the fluids exiting from the vents suggests a highly restricted circulation system involving, at times, little to no mixing with cold seawater. The lava terrain in the remainder of Zone l and bordering regions is characterized by extensive fracturing, further suggesting a narrow upper dimension to the magma chamber and also that subsurface hydrothermal deposition of massive sulfides may lead to a reduction in the mixing processes.

  13. East Pacific rise at 21°N: The volcanic, tectonic, and hydrothermal processes of the central axis

    NASA Astrophysics Data System (ADS)

    Ballard, Robert D.; Francheteau, Jean; Juteau, Tierre; Rangan, Claude; Normark, William

    1981-09-01

    Photographs obtained by the ANGUS survey system at 21°N reveal many similarities to the geological processes delineated at other spreading centers and in particular those observed in the Galapagos Rift at 86°W. The region of recent volcanism is restricted to a narrow zone (Zone 1) approximately 1 km wide. This suggests that the width of the magma chamber feeding these flows is also narrow at the top. Variations in sediment cover are used to subdivide the flows within Zone 1 into three sheet-flow/pillow-flow pairs. The youngest pair appears to have erupted form a linear fissure 8 km long running parallel to the valley axis. This fissure is part of a larger en echelon pattern of eruptive fissures. Active hydrothermal vents associated with the youngest flows are situated directly above the apparent eruptive fissure. The high (350°C) temperature for some of the fluids exiting from the vents suggests a highly restricted circulation system involving, at times, little to no mixing with cold seawater. The lava terrain in the remainder of Zone 1 and bordering regions is characterized by extensive fracturing, further suggesting a narrow upper dimension to the magma chamber and also that subsurface hydrothermal deposition of massive sulfides may lead to a reduction in the mixing processes.

  14. Zoned Out: "NIMBYism", addiction services and municipal governance in British Columbia.

    PubMed

    Bernstein, Scott E; Bennett, Darcie

    2013-11-01

    In Canada, Provincial Governments have jurisdiction over delivery of healthcare including harm reduction services and Methadone Maintenance Therapy (MMT). While policy directives and funding come from the provincial capital, individuals' access to these services happens in neighbourhoods and municipalities spread out across the province. In some cases, public health objectives targeted at people living with addictions and the rights to equitable access to healthcare are at odds with the vision that residents, business associations and other interest groups have for their neighbourhood or city. This paper looks at the cases of four British Columbia municipalities, Mission, Surrey, Coquitlam and Abbotsford, where local governments have used zoning provisions to restrict access to harm reduction services and drug substitution therapies including MMT. This paper will contextualize these case studies in a survey of zoning and bylaw provisions related to harm reduction and MMT across British Columbia, and examine the interplay between municipal actions and public discourses that affect access to healthcare for people living with addictions. Finally, this paper will explore possible legal implications for municipalities that use their zoning and permitting powers to restrict access to health care for people with addictions, as well as public engagement strategies for healthcare advocates that have the potential to reduce resistance to health services for people living with addictions in communities across the province. Copyright © 2013 Elsevier B.V. All rights reserved.

  15. Assessment of Factors Related to Auto-PEEP.

    PubMed

    Natalini, Giuseppe; Tuzzo, Daniele; Rosano, Antonio; Testa, Marco; Grazioli, Michele; Pennestrì, Vincenzo; Amodeo, Guido; Marsilia, Paolo F; Tinnirello, Andrea; Berruto, Francesco; Fiorillo, Marialinda; Filippini, Matteo; Peratoner, Alberto; Minelli, Cosetta; Bernardini, Achille

    2016-02-01

    Previous physiological studies have identified factors that are involved in auto-PEEP generation. In our study, we examined how much auto-PEEP is generated from factors that are involved in its development. One hundred eighty-six subjects undergoing controlled mechanical ventilation with persistent expiratory flow at the beginning of each inspiration were enrolled in the study. Volume-controlled continuous mandatory ventilation with PEEP of 0 cm H2O was applied while maintaining the ventilator setting as chosen by the attending physician. End-expiratory and end-inspiratory airway occlusion maneuvers were performed to calculate respiratory mechanics, and tidal flow limitation was assessed by a maneuver of manual compression of the abdomen. The variable with the strongest effect on auto-PEEP was flow limitation, which was associated with an increase of 2.4 cm H2O in auto-PEEP values. Moreover, auto-PEEP values were directly related to resistance of the respiratory system and body mass index and inversely related to expiratory time/time constant. Variables that were associated with the breathing pattern (tidal volume, frequency minute ventilation, and expiratory time) did not show any relationship with auto-PEEP values. The risk of auto-PEEP ≥5 cm H2O was increased by flow limitation (adjusted odds ratio 17; 95% CI: 6-56.2), expiratory time/time constant ratio <1.85 (12.6; 4.7-39.6), respiratory system resistance >15 cm H2O/L s (3; 1.3-6.9), age >65 y (2.8; 1.2-6.5), and body mass index >26 kg/m(2) (2.6; 1.1-6.1). Flow limitation, expiratory time/time constant, resistance of the respiratory system, and obesity are the most important variables that affect auto-PEEP values. Frequency expiratory time, tidal volume, and minute ventilation were not independently associated with auto-PEEP. Therapeutic strategies aimed at reducing auto-PEEP and its adverse effects should be primarily oriented to the variables that mainly affect auto-PEEP values. Copyright © 2016 by Daedalus Enterprises.

  16. Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease.

    PubMed

    Akhtar, Rizwan S; Licata, Joseph P; Luk, Kelvin C; Shaw, Leslie M; Trojanowski, John Q; Lee, Virginia M-Y

    2018-03-03

    Biomarkers for α-synuclein are needed for diagnosis and prognosis in Parkinson's disease (PD). Endogenous auto-antibodies to α-synuclein could serve as biomarkers for underlying synucleinopathy, but previous assessments of auto-antibodies have shown variability and inconsistent clinical correlations. We hypothesized that auto-antibodies to α-synuclein could be diagnostic for PD and explain its clinical heterogeneity. To test this hypothesis, we developed an enzyme-linked immunosorbent assay for measuring α-synuclein auto-antibodies in human samples. We evaluated 69 serum samples (16 healthy controls (HC) and 53 PD patients) and 145 CSF samples (52 HC and 93 PD patients) from our Institution. Both serum and CSF were available for 24 participants. Males had higher auto-antibody levels than females in both fluids. CSF auto-antibody levels were significantly higher in PD patients as compared to HC, whereas serum levels were not significantly different. CSF auto-antibody levels did not associate with amyloid-β 1-42 , total tau, or phosphorylated tau. CSF auto-antibody levels correlated with performance on the Montreal Cognitive Assessment, even when controlled for CSF amyloidβ 1-42 . CSF hemoglobin levels, as a proxy for contamination of CSF by blood during lumbar puncture, did not influence these observations. Using recombinant α-synuclein with N- and C-terminal truncations, we found that CSF auto-antibodies target amino acids 100 through 120 of α-synuclein. We conclude that endogenous CSF auto-antibodies are significantly higher in PD patients as compared to HC, suggesting that they could indicate the presence of underlying synucleinopathy. These auto-antibodies associate with poor cognition, independently of CSF amyloidβ 1-42 ., and target a select C-terminal region of α-synuclein. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

  17. Autologous Transplantation in Follicular Lymphoma with Early Therapy Failure: A National LymphoCare Study and Center for International Blood and Marrow Transplant Research Analysis.

    PubMed

    Casulo, Carla; Friedberg, Jonathan W; Ahn, Kwang W; Flowers, Christopher; DiGilio, Alyssa; Smith, Sonali M; Ahmed, Sairah; Inwards, David; Aljurf, Mahmoud; Chen, Andy I; Choe, Hannah; Cohen, Jonathon; Copelan, Edward; Farooq, Umar; Fenske, Timothy S; Freytes, Cesar; Gaballa, Sameh; Ganguly, Siddhartha; Jethava, Yogesh; Kamble, Rammurti T; Kenkre, Vaishalee P; Lazarus, Hillard; Lazaryan, Aleksandr; Olsson, Richard F; Rezvani, Andrew R; Rizzieri, David; Seo, Sachiko; Shah, Gunjan L; Shah, Nina; Solh, Melham; Sureda, Anna; William, Basem; Cumpston, Aaron; Zelenetz, Andrew D; Link, Brian K; Hamadani, Mehdi

    2018-06-01

    Patients with follicular lymphoma (FL) experiencing early therapy failure (ETF) within 2 years of frontline chemoimmunotherapy have poor overall survival (OS). We analyzed data from the Center for International Blood and Marrow Transplant Research (CIBMTR) and the National LymphoCare Study (NLCS) to determine whether autologous hematopoietic cell transplant (autoHCT) can improve outcomes in this high-risk FL subgroup. ETF was defined as failure to achieve at least partial response after frontline chemoimmunotherapy or lymphoma progression within 2 years of frontline chemoimmunotherapy. We identified 2 groups: the non-autoHCT cohort (patients from the NLCS with ETF not undergoing autoHCT) and the autoHCT cohort (CIBMTR patients with ETF undergoing autoHCT). All patients received rituximab-based chemotherapy as frontline treatment; 174 non-autoHCT patients and 175 autoHCT patients were identified and analyzed. There was no difference in 5-year OS between the 2 groups (60% versus 67%, respectively; P = .16). A planned subgroup analysis showed that patients with ETF receiving autoHCT soon after treatment failure (≤1 year of ETF; n = 123) had higher 5-year OS than those without autoHCT (73% versus 60%, P = .05). On multivariate analysis, early use of autoHCT was associated with significantly reduced mortality (hazard ratio, .63; 95% confidence interval, .42 to .94; P = .02). Patients with FL experiencing ETF after frontline chemoimmunotherapy lack optimal therapy. We demonstrate improved OS when receiving autoHCT within 1 year of treatment failure. Results from this unique collaboration between the NLCS and CIBMTR support consideration of early consolidation with autoHCT in select FL patients experiencing ETF. Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

  18. Identification of the regulatory autophosphorylation site of autophosphorylation-dependent protein kinase (auto-kinase). Evidence that auto-kinase belongs to a member of the p21-activated kinase family.

    PubMed

    Yu, J S; Chen, W J; Ni, M H; Chan, W H; Yang, S D

    1998-08-15

    Autophosphorylation-dependent protein kinase (auto-kinase) was identified from pig brain and liver on the basis of its unique autophosphorylation/activation property [Yang, Fong, Yu and Liu (1987) J. Biol. Chem. 262, 7034-7040; Yang, Chang and Soderling (1987) J. Biol. Chem. 262, 9421-9427]. Its substrate consensus sequence motif was determined as being -R-X-(X)-S*/T*-X3-S/T-. To characterize auto-kinase further, we partly sequenced the kinase purified from pig liver. The N-terminal sequence (VDGGAKTSDKQKKKAXMTDE) and two internal peptide sequences (EKLRTIV and LQNPEK/ILTP/FI) of auto-kinase were obtained. These sequences identify auto-kinase as a C-terminal catalytic fragment of p21-activated protein kinase 2 (PAK2 or gamma-PAK) lacking its N-terminal regulatory region. Auto-kinase can be recognized by an antibody raised against the C-terminal peptide of human PAK2 by immunoblotting. Furthermore the autophosphorylation site sequence of auto-kinase was successfully predicted on the basis of its substrate consensus sequence motif and the known PAK2 sequence, and was further demonstrated to be RST(P)MVGTPYWMAPEVVTR by phosphoamino acid analysis, manual Edman degradation and phosphopeptide mapping via the help of phosphorylation site analysis of a synthetic peptide corresponding to the sequence of PAK2 from residues 396 to 418. During the activation process, auto-kinase autophosphorylates mainly on a single threonine residue Thr402 (according to the sequence numbering of human PAK2). In addition, a phospho-specific antibody against a synthetic phosphopeptide containing this identified sequence was generated and shown to be able to differentially recognize the activated auto-kinase autophosphorylated at Thr402 but not the non-phosphorylated/inactive auto-kinase. Immunoblot analysis with this phospho-specific antibody further revealed that the change in phosphorylation level of Thr402 of auto-kinase was well correlated with the activity change of the kinase during both autophosphorylation/activation and protein phosphatase-mediated dephosphorylation/inactivation processes. Taken together, our results identify Thr402 as the regulatory autophosphorylation site of auto-kinase, which is a C-terminal catalytic fragment of PAK2.

  19. Identification of the regulatory autophosphorylation site of autophosphorylation-dependent protein kinase (auto-kinase). Evidence that auto-kinase belongs to a member of the p21-activated kinase family.

    PubMed Central

    Yu, J S; Chen, W J; Ni, M H; Chan, W H; Yang, S D

    1998-01-01

    Autophosphorylation-dependent protein kinase (auto-kinase) was identified from pig brain and liver on the basis of its unique autophosphorylation/activation property [Yang, Fong, Yu and Liu (1987) J. Biol. Chem. 262, 7034-7040; Yang, Chang and Soderling (1987) J. Biol. Chem. 262, 9421-9427]. Its substrate consensus sequence motif was determined as being -R-X-(X)-S*/T*-X3-S/T-. To characterize auto-kinase further, we partly sequenced the kinase purified from pig liver. The N-terminal sequence (VDGGAKTSDKQKKKAXMTDE) and two internal peptide sequences (EKLRTIV and LQNPEK/ILTP/FI) of auto-kinase were obtained. These sequences identify auto-kinase as a C-terminal catalytic fragment of p21-activated protein kinase 2 (PAK2 or gamma-PAK) lacking its N-terminal regulatory region. Auto-kinase can be recognized by an antibody raised against the C-terminal peptide of human PAK2 by immunoblotting. Furthermore the autophosphorylation site sequence of auto-kinase was successfully predicted on the basis of its substrate consensus sequence motif and the known PAK2 sequence, and was further demonstrated to be RST(P)MVGTPYWMAPEVVTR by phosphoamino acid analysis, manual Edman degradation and phosphopeptide mapping via the help of phosphorylation site analysis of a synthetic peptide corresponding to the sequence of PAK2 from residues 396 to 418. During the activation process, auto-kinase autophosphorylates mainly on a single threonine residue Thr402 (according to the sequence numbering of human PAK2). In addition, a phospho-specific antibody against a synthetic phosphopeptide containing this identified sequence was generated and shown to be able to differentially recognize the activated auto-kinase autophosphorylated at Thr402 but not the non-phosphorylated/inactive auto-kinase. Immunoblot analysis with this phospho-specific antibody further revealed that the change in phosphorylation level of Thr402 of auto-kinase was well correlated with the activity change of the kinase during both autophosphorylation/activation and protein phosphatase-mediated dephosphorylation/inactivation processes. Taken together, our results identify Thr402 as the regulatory autophosphorylation site of auto-kinase, which is a C-terminal catalytic fragment of PAK2. PMID:9693111

  20. Validating Variance Similarity Functions in the Entrainment Zone

    NASA Astrophysics Data System (ADS)

    Osman, M.; Turner, D. D.; Heus, T.; Newsom, R. K.

    2017-12-01

    In previous work, the water vapor variance in the entrainment zone was proposed to be proportional to the convective velocity scale, gradient water vapor mixing ratio and the Brunt-Vaisala frequency in the interfacial layer, while the variance of the vertical wind at in the entrainment zone was defined in terms of the convective velocity scale. The variances in the entrainment zone have been hypothesized to depend on two distinct functions, which also depend on the Richardson number. To the best of our knowledge, these hypotheses have never been tested observationally. Simultaneous measurements of the Eddy correlation surface flux, wind shear profiles from wind profilers, and variance profile measurements of vertical motions and water vapor by Doppler and Raman lidars, respectively, provide a unique opportunity to thoroughly examine the functions used in defining the variances and validate them. These observations were made over the Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) site. We have identified about 30 cases from 2016 during which the convective boundary layer (CBL) is quasi-stationary and well mixed for at least 2 hours. The vertical profiles of turbulent fluctuations of the vertical wind and water vapor have been derived using an auto covariance technique to separate out the instrument random error to a set of 2-h period time series. The error analysis of the lidars observations demonstrates that the lidars are capable of resolving the vertical structure of turbulence around the entrainment zone. Therefore, utilizing this unique combination of observations, this study focuses on extensively testing the hypotheses that the second-order moments are indeed proportional to the functions which also depend on Richardson number. The coefficients that are used in defining the functions will also be determined observationally and compared against with the values suggested by Large eddy simulation (LES) studies.

  1. Aberration analyses for improving the frontal projection three-dimensional display.

    PubMed

    Gao, Xin; Sang, Xinzhu; Yu, Xunbo; Wang, Peng; Cao, Xuemei; Sun, Lei; Yan, Binbin; Yuan, Jinhui; Wang, Kuiru; Yu, Chongxiu; Dou, Wenhua

    2014-09-22

    The crosstalk severely affects the viewing experience for the auto-stereoscopic 3D displays based on frontal projection lenticular sheet. To suppress unclear stereo vision and ghosts are observed in marginal viewing zones(MVZs), aberration of the lenticular sheet combining with the frontal projector is analyzed and designed. Theoretical and experimental results show that increasing radius of curvature (ROC) or decreasing aperture of the lenticular sheet can suppress the aberration and reduce the crosstalk. A projector array with 20 micro-projectors is used to frontally project 20 parallax images one lenticular sheet with the ROC of 10 mm and the size of 1.9 m × 1.2 m. The 3D image with the high quality is experimentally demonstrated in both the mid-viewing zone and MVZs in the optimal viewing plane. The 3D clear depth of 1.2m can be perceived. To provide an excellent 3D image and enlarge the field of view at the same time, a novel structure of lenticular sheet is presented to reduce aberration, and the crosstalk is well suppressed.

  2. 50 CFR 622.46 - Prevention of gear conflicts.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... restrictions of the FMP for the Shrimp Fishery of the Gulf of Mexico, the RA may modify or establish separation zones for shrimp trawling and the use of fixed gear to prevent gear conflicts. Necessary prohibitions or...

  3. Increased symplasmic permeability in barley root epidermal cells correlates with defects in root hair development

    PubMed Central

    Marzec, M; Muszynska, A; Melzer, M; Sas-Nowosielska, H; Kurczynska, E U; Wick, S

    2014-01-01

    It is well known that the process of plant cell differentiation depends on the symplasmic isolation of cells. Before starting the differentiation programme, the individual cell or group of cells should restrict symplasmic communication with neighbouring cells. We tested the symplasmic communication between epidermal cells in the different root zones of parental barley plants Hordeum vulgare L., cv. ‘Karat’ with normal root hair development, and two root hairless mutants (rhl1.a and rhl1.b). The results clearly show that symplasmic communication was limited during root hair differentiation in the parental variety, whereas in both root hairless mutants epidermal cells were still symplasmically connected in the corresponding root zone. This paper is the first report on the role of symplasmic isolation in barley root cell differentiation, and additionally shows that a disturbance in the restriction of symplasmic communication is present in root hairless mutants. PMID:23927737

  4. The Relationship between Affective States and Dialog Patterns during Interactions with AutoTutor

    ERIC Educational Resources Information Center

    Graesser, Arthur C.; D'Mello, Sidney K.; Craig, Scotty D.; Witherspoon, Amy; Sullins, Jeremiah; McDaniel, Bethany; Gholson, Barry

    2008-01-01

    Relations between emotions (affect states) and learning have recently been explored in the context of AutoTutor. AutoTutor is a tutoring system on the Internet that helps learners construct answers to difficult questions by interacting with them in natural language. AutoTutor has an animated conversation agent and a dialog management facility that…

  5. 46 CFR 97.16-1 - Use of auto pilot.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Use of auto pilot. 97.16-1 Section 97.16-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Auto Pilot § 97.16-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used...

  6. 46 CFR 97.16-1 - Use of auto pilot.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Use of auto pilot. 97.16-1 Section 97.16-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Auto Pilot § 97.16-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used...

  7. 46 CFR 78.19-1 - Use of auto pilot.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 3 2012-10-01 2012-10-01 false Use of auto pilot. 78.19-1 Section 78.19-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Auto Pilot § 78.19-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used in— (a...

  8. 46 CFR 97.16-1 - Use of auto pilot.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Use of auto pilot. 97.16-1 Section 97.16-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Auto Pilot § 97.16-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used...

  9. 46 CFR 78.19-1 - Use of auto pilot.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 3 2014-10-01 2014-10-01 false Use of auto pilot. 78.19-1 Section 78.19-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Auto Pilot § 78.19-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used in— (a...

  10. 46 CFR 78.19-1 - Use of auto pilot.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 3 2013-10-01 2013-10-01 false Use of auto pilot. 78.19-1 Section 78.19-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Auto Pilot § 78.19-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used in— (a...

  11. AutoTutor and Family: A Review of 17 Years of Natural Language Tutoring

    ERIC Educational Resources Information Center

    Nye, Benjamin D.; Graesser, Arthur C.; Hu, Xiangen

    2014-01-01

    AutoTutor is a natural language tutoring system that has produced learning gains across multiple domains (e.g., computer literacy, physics, critical thinking). In this paper, we review the development, key research findings, and systems that have evolved from AutoTutor. First, the rationale for developing AutoTutor is outlined and the advantages…

  12. Electrical Systems. Auto Mechanics Curriculum Guide Module 2. Instructor's Guide.

    ERIC Educational Resources Information Center

    Hevel, David; Donovan, Roger

    This document is one of a series of modules in the Missouri Auto Mechanics Curriculum Guide, which is based on 144 basic auto mechanics competencies identified on the Missouri Auto Mechanics Competency Profile. The instructor's materials in this document are for a 14-unit secondary education course. The following units are included: (1) principles…

  13. Manual Drive Train and Axles. Auto Mechanics Curriculum Guide Module 7. Instructor's Guide.

    ERIC Educational Resources Information Center

    Colesworthy, Robert; Donovan, Roger

    This document is one of a series of modules in the Missouri Auto Mechanics Curriculum Guide, which is based on 144 basic auto mechanics competencies identified on the Missouri Auto Mechanics Competency Profile. The instructor's materials in this document are for a 13-unit secondary education course. The following units are included: (1)…

  14. 46 CFR 97.16-1 - Use of auto pilot.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Use of auto pilot. 97.16-1 Section 97.16-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Auto Pilot § 97.16-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used...

  15. 46 CFR 78.19-1 - Use of auto pilot.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 3 2010-10-01 2010-10-01 false Use of auto pilot. 78.19-1 Section 78.19-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Auto Pilot § 78.19-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used in— (a...

  16. 77 FR 16227 - Frank Myers AutoMaxx, LLC; Analysis of Proposed Consent Order To Aid Public Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... FEDERAL TRADE COMMISSION [File No. 112 3206] Frank Myers AutoMaxx, LLC; Analysis of Proposed... ``Frank Myers AutoMaxx, File No. 112 3206'' on your comment, and file your comment online at https... April 16, 2012. Write ``Frank Myers AutoMaxx, File No. 112 3206'' on your comment. Your comment...

  17. 75 FR 65524 - United Auto Workers Local 1999, Oklahoma City, OK; Notice of Negative Determination Regarding...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-25

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-71,863] United Auto Workers Local... workers and former workers of United Auto Workers Local 1999, Oklahoma City, Oklahoma (the subject firm... Auto Workers Local 1999, Oklahoma City, Oklahoma, was based on the findings that the workers at the...

  18. 46 CFR 78.19-1 - Use of auto pilot.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 3 2011-10-01 2011-10-01 false Use of auto pilot. 78.19-1 Section 78.19-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS OPERATIONS Auto Pilot § 78.19-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used in— (a...

  19. 46 CFR 97.16-1 - Use of auto pilot.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Use of auto pilot. 97.16-1 Section 97.16-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS OPERATIONS Auto Pilot § 97.16-1 Use of auto pilot. Except as provided in 33 CFR 164.15, when the automatic pilot is used...

  20. [Microbial diversity of sediments from the coasts of Dalian Changshan Islands].

    PubMed

    Li, Jialin; Wang, Zhonghua; Qin, Song; Wang, Guangyi

    2011-05-01

    To understand the impacts of anthropogenic activities on structure and composition of bacterial communities and to evaluate how bacterial communities respond to environmental gradients at coastal sediments. The diversity of bacterial communities in sediments from tourist and mariculture zones at coastal area of Dalian Changshan Islands was assessed using terminal restriction fragment length polymorphism (t-RFLP) and denaturing gradient gel electrophoresis (DGGE) approaches. Meanwhile, 16S rRNA clone library was constructed to reveal the composition and structure of bacterial communities in the most seriously polluted site (D4). There were much higher values of richness, Shannon-wiener and evenness index at D4 site by the analysis of terminal restriction fragments (t-RFs). The clustering result on the t-RFs areas and DGGE patterns showed that the bacterial diversity of tourist zone were more similar, while the distinction was increased with pollution levels among the tourist and mariculture zones. The 16S rRNA clone of D4 revealed that the Proteobacteria were the dominant phylum, and gamma-proteobacteria was the main class within Proteobacteria. The study documented changes in bacterial community structure by human impacts of mariculture than geographical location.

  1. TLR4 signaling augments B lymphocyte migration and overcomes the restriction that limits access to germinal center dark zones

    PubMed Central

    Hwang, Il-Young; Park, Chung; Harrison, Kathleen

    2009-01-01

    B lymphocyte–intrinsic Toll-like receptor (TLR) signals amplify humoral immunity and can exacerbate autoimmune diseases. We identify a new mechanism by which TLR signals may contribute to autoimmunity and chronic inflammation. We show that TLR4 signaling enhances B lymphocyte trafficking into lymph nodes (LNs), induces B lymphocyte clustering and interactions within LN follicles, leads to sustained in vivo B cell proliferation, overcomes the restriction that limits the access of nonantigen-activated B cells to germinal center dark zones, and enhances the generation of memory and plasma cells. Intravital microscopy and in vivo tracking studies of B cells transferred to recipient mice revealed that TLR4-activated, but not nonstimulated, B cells accumulated within the dark zones of preexisting germinal centers even when transferred with antigen-specific B cells. The TLR4-activated cells persist much better than nonstimulated cells, expanding both within the memory and plasma cell compartments. TLR-mediated activation of B cells may help to feed and stabilize the spontaneous and ectopic germinal centers that are so commonly found in autoimmune individuals and that accompany chronic inflammation. PMID:19917774

  2. --No Title--

    Science.gov Websites

    ; margin-left: auto; margin-right: auto; } .slick-track:before, .slick-track:after { display: table : auto; border: 1px solid transparent; } .slick-arrow.slick-hidden { display: none;

  3. An Angus/Argo study of the neovolcanic zone along the East Pacific rise from the Clipperton fracture zone to 12°N

    NASA Astrophysics Data System (ADS)

    Uchupi, E.; Schwab, W. C.; Ballard, R. D.; Cheminee, J. L.; Francheteau, J.; Hekinian, R.; Blackman, D. K.; Sigurdsson, H.

    1988-09-01

    Still photographs and video images collected along the Neovolcanic Zone of the East Pacific Rise from 10°15'N to 11°53'N show that recent volcanic sheet flows, possibly less than 100 years old, are superimposed on an older sediment-laden pillow terrane. This recent activity is restricted to a narrow zone that crosses two topographic highs at 10°55'N and 11°26'N and diminishes along-axis away from these highs. The association of recent sheet flows with older flows and collapse structures on the overlapping spreading centers at 11°45'N supports the evolutionary model for the occurrence and evolution of overlapping spreading centers by MacDonald and others (1986, 1988).

  4. Clinical utility of anti-p53 auto-antibody: Systematic review and focus on colorectal cancer

    PubMed Central

    Suppiah, Aravind; Greenman, John

    2013-01-01

    Mutation of the p53 gene is a key event in the carcinogenesis of many different types of tumours. These can occur throughout the length of the p53 gene. Anti-p53 auto-antibodies are commonly produced in response to these p53 mutations. This review firstly describes the various mechanisms of p53 dysfunction and their association with subsequent carcinogenesis. Following this, the mechanisms of induction of anti-p53 auto-antibody production are shown, with various hypotheses for the discrepancies between the presence of p53 mutation and the presence/absence of anti-p53 auto-antibodies. A systematic review was performed with a descriptive summary of key findings of each anti-p53 auto-antibody study in all cancers published in the last 30 years. Using this, the cumulative frequency of anti-p53 auto-antibody in each cancer type is calculated and then compared with the incidence of p53 mutation in each cancer to provide the largest sample calculation and correlation between mutation and anti-p53 auto-antibody published to date. Finally, the review focuses on the data of anti-p53 auto-antibody in colorectal cancer studies, and discusses future strategies including the potentially promising role using anti-p53 auto-antibody presence in screening and surveillance. PMID:23922463

  5. Auto Body Welding 2 (Course Outline), Automotive Body Repair and Refinishing 1: 9033.04.

    ERIC Educational Resources Information Center

    Dade County Public Schools, Miami, FL.

    The 90-hour course is a foundation quinmester course in welding for the auto body repairman. The outline consists of seven blocks of instruction (orientation, 6 hours; auto body oxyacetylene welding, 10 hours; electric arc welding equipment, 6 hours; auto body electric arc welding, 8 hours; position welding, 40 hours; electric spot welders, 16…

  6. A phase II study of V-BEAM as conditioning regimen before second auto-SCT for multiple myeloma.

    PubMed

    Wang, T-F; Fiala, M A; Cashen, A F; Uy, G L; Abboud, C N; Fletcher, T; Wu, N; Westervelt, P; DiPersio, J F; Stockerl-Goldstein, K E; Vij, R

    2014-11-01

    High-dose melphalan has been the standard conditioning regimen for auto-SCT in multiple myeloma (MM) for decades. A more effective conditioning regimen may induce deeper responses and longer remission duration. It is especially needed in the setting of second auto-SCT, which rarely achieves comparable results with the first auto-SCT using the same conditioning regimen. Here we conducted a phase II study to investigate the efficacy and safety of a conditioning regimen V-BEAM (bortezomib-BEAM) before second auto-SCT for multiple myeloma. Ten patients were enrolled from September 2012 to May 2013. The CR rate at day +100 after auto-SCT was 75%; all except for one patient remained in remission after a median follow-up of 6 months. Three patients developed Clostridium difficile infection. Two patients died within the first 30 days of auto-SCT from neutropenic colitis and overwhelming sepsis, respectively. Due to the high rate of morbidity and mortality, the study was terminated after 10 patients. In summary, although the conditioning regimen V-BEAM before second auto-SCT for MM provided promising responses, it was associated with unexpected treatment-related toxicity and should not be investigated further without modifications.

  7. What factors affect the carriage of epinephrine auto-injectors by teenagers?

    PubMed

    Macadam, Clare; Barnett, Julie; Roberts, Graham; Stiefel, Gary; King, Rosemary; Erlewyn-Lajeunesse, Michel; Holloway, Judith A; Lucas, Jane S

    2012-02-02

    Teenagers with allergies are at particular risk of severe and fatal reactions, but epinephrine auto-injectors are not always carried as prescribed. We investigated barriers to carriage. Patients aged 12-18 years old under a specialist allergy clinic, who had previously been prescribed an auto-injector were invited to participate. Semi-structured interviews explored the factors that positively or negatively impacted on carriage. Twenty teenagers with food or venom allergies were interviewed. Only two patients had used their auto-injector in the community, although several had been treated for severe reactions in hospital. Most teenagers made complex risk assessments to determine whether to carry the auto-injector. Most but not all decisions were rational and were at least partially informed by knowledge. Factors affecting carriage included location, who else would be present, the attitudes of others and physical features of the auto-injector. Teenagers made frequent risk assessments when deciding whether to carry their auto-injectors, and generally wanted to remain safe. Their decisions were complex, multi-faceted and highly individualised. Rather than aiming for 100% carriage of auto-injectors, which remains an ambitious ideal, personalised education packages should aim to empower teenagers to make and act upon informed risk assessments.

  8. Studies of the Solar Radiations' Influence About Geomembranes Used in Ecological Landfill

    NASA Astrophysics Data System (ADS)

    Vasiluta, Petre; Cofaru, Ileana Ioana; Cofaru, Nicolae Florin; Popa, Dragos Laurentiu

    2017-12-01

    The study shown in this paper presents the behavior of geomembranes used at the ecological landfills. The influences of the solar radiations has a great importance regarding the correct mounting of the geomembranes. The mathematical model developed for the determination anytime and anywhere in the world for the next values and parameters: apparent solar time, solar declination, solar altitude, solar azimuth and incidence angle, zone angle, angle of sun elevation, solar declination, solar constant, solar flux density, diffuse solar radiation, global radiation, soil albedo, total radiant flux density and relational links of these values. The results of this model was used for creations an AutoCAD subroutines useful for choosing the correct time for correct mounting anywhere of the geomembranes

  9. 77 FR 13525 - Safety Zone; Rocketts Red Glare Fireworks, Ancarrows Landing Park, James River, Richmond, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ... enclose a stamped, self-addressed postcard or envelope. We will consider all comments and material..., dangerous projectiles, and falling hot embers or other debris, vessel traffic will be temporarily restricted...

  10. Auto-immune hepatitis following delivery.

    PubMed

    Saini, Vandana; Gupta, Mamta; Mishra, S K

    2013-05-01

    Auto-immune hepatitis first presenting in the early postpartum period is rare. Immunosuppressive effects of pregnancy result in delayed manifestation of auto-immune hepatitis, and in established cases, the spontaneous improvements are there. Auto-immune hepatitis should be considered in the differential diagnosis of liver dysfunction first presenting in the early postpartum period. A case of postpartum hepatitis of auto-immune aetiology is being presented here. It is disease of unknown aetiology, characterised by inflammation of liver (as evidenced by raised serum transaminases, presence of interface hepatitis on histological examination), hypergammaglobulinaemia (> 1.5 times normal), presence of auto-antibodies [(antinuclear antibodies (ANA)], smooth muscle antibody (SMA) and antibody to liver-kidney microsome type 1 (LKM1) in the absence of viral markers ie, hepatitis B (HBsAg) and C (AntiHCV) and excellent response to corticosteroid therapy.

  11. The French short term radiopropagation predictions in the decameter band

    NASA Technical Reports Server (NTRS)

    Lassudrie-Duchesne, P.; Bourdila, A. M.; Sizun, H.

    1979-01-01

    Weekly and daily predictions of the ionospheric characteristics relevant to radio propagation are considered. A description of the techniques involved is given as well as examples showing how the prediction messages are prepared. The short term predictions are confined to restricted geographical areas and are relevant to radio circuits whose terminators are both located inside the same zone. They can be used with a reasonable approximation for circuits less than 3000 km of length whose reflection point lies within a given zone.

  12. A Needs Assessment of Entry-Level Competencies for Modification of an Auto Body Repair Curriculum.

    ERIC Educational Resources Information Center

    Borremans, Robert T.

    A needs assessment was conducted to determine job tasks relevant for entry-level auto body repairers as a basis for updating the Auto Body Program at Blackhawk Technical Institute (BTI). A survey was mailed to 86 local auto body shops, asking employers to rank 149 tasks in 11 duty areas in terms of importance and frequency performed. Study…

  13. 77 FR 39767 - Self-Regulatory Organizations; National Stock Exchange, Inc.; Notice of Filing and Immediate...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-05

    ... has executed on average per trading day (excluding partial trading days) in AutoEx or Order Delivery... (``AutoEx'') shall mean only those executed shares of the ETP Holder that are submitted in AutoEx mode... period, a combined ADV in both AutoEx and Order Delivery of at least 11.5 million shares, of which at...

  14. Incidence of auto-immune pemphigus in the Midi-Pyrénées region in 2002-2006.

    PubMed

    Thomas, M; Paul, C; Berard, E; Fortenfant, F; Mazereeuw-Hautier, J; Livideanu, C; Viraben, R; Meyer, N

    2010-01-01

    Auto-immune pemphigus is an organ-specific immune disorder due to pathogenic auto-antibodies. Both genetic and environmental factors have been associated with the occurrence of auto-immune pemphigus. Little is known about the epidemiology of auto-immune pemphigus in western Europe. To evaluate the incidence of auto-immune pemphigus in south-western France (namely the Midi-Pyrénées region) in a 5-year period between 2002 and 2006. We performed a retrospective study of the annual incidence of auto-immune pemphigus diagnosed in the Midi-Pyrénées region, between January 1, 2002, and December 31, 2006. Possible cases of pemphigus were initially selected using skin direct immunofluorescence (DIF) databases from all laboratories in the Midi-Pyrénées region. Systematic validation of all cases was performed by two of the authors (N.M., M.T.). To qualify as a case of auto-immune pemphigus, patients had to fulfil the following criteria: history of clinical signs of pemphigus as assessed by a dermatologist and a positive DIF. To be included in the study, validated cases of auto-immune pemphigus had to fulfil the following criteria: the date of first positive skin DIF between January 1, 2002, and December 31, 2006, and patient living in the Midi-Pyrénées region at the time of the first positive skin DIF. Between 2002 and 2006, 91 patients with positive DIF were identified. Fifty-four patients with positive DIF did not meet the validation criteria for the study. Thirty-seven cases were included in the analysis. The crude annual mean incidence of auto-immune pemphigus between 2002 and 2006 was 2.7 cases/10(6) inhabitants/year (95% CI: 1.87-3.69). The world-population-standardized annual mean incidence of auto-immune pemphigus was 1.55 (95% CI: 0.99-2.11). We report a 1.55/10(6) inhabitants/year world-population-standardized incidence of auto-immune pemphigus in the south-west of France. A nationwide epidemiological study of pemphigus should be performed in France.

  15. Stitching-aware in-design DPT auto fixing for sub-20nm logic devices

    NASA Astrophysics Data System (ADS)

    Choi, Soo-Han; Sai Krishna, K. V. V. S.; Pemberton-Smith, David

    2017-03-01

    As the technology continues to shrink below 20nm, Double Patterning Technology (DPT) becomes one of the mandatory solutions for routing metal layers. From the view point of Place and Route (P&R), the major concerns are how to prevent DPT odd-cycles automatically without sacrificing chip area. Even though the leading-edge P&R tools have advanced algorithms to prevent DPT odd-cycles, it is very hard to prevent the localized DPT odd-cycles, especially in Engineering Change Order (ECO) routing. In the last several years, we developed In-design DPT Auto Fixing method in order to reduce localized DPT odd-cycles significantly during ECO and could achieve remarkable design Turn-Around Times (TATs). But subsequently, as the design complexity continued increasing and chip size continued decreasing, we needed a new In-design DPT Auto Fixing approach to improve the auto. fixing rate. In this paper, we present the Stitching-Aware In-design DPT Auto Fixing method for better fixing rates and smaller chip design. The previous In-design DPT Auto Fixing method detected all DPT odd-cycles and tried to remove oddcycles by increasing the adjacent space. As the metal congestions increase in the newer technology nodes, the older Auto Fixing method has limitations to increase the adjacent space between routing metals. Consequently, the auto fixing rate of older method gets worse with the introduction of the smaller design rules. With DPT stitching enablement at In-design DRC checking procedure, the new Stitching-Aware DPT Auto Fixing method detects the most critical odd-cycles and revolve the odd-cycles automatically. The accuracy of new flow ensures better usage of space in the congested areas, and helps design more smaller chips. By applying the Stitching-Aware DPT Auto Fixing method to sub-20nm logic devices, we can confirm that the auto fixing rate is improved by 2X compared with auto fixing without stitching. Additionally, by developing the better heuristic algorithm and flow for DPT stitching, we can get DPT compliant layout with the acceptable design TATs.

  16. Double-lumen tubes and auto-PEEP during one-lung ventilation.

    PubMed

    Spaeth, J; Ott, M; Karzai, W; Grimm, A; Wirth, S; Schumann, S; Loop, T

    2016-01-01

    Double-lumen tubes (DLT) are routinely used to enable one-lung-ventilation (OLV) during thoracic anaesthesia. The flow-dependent resistance of the DLT's bronchial limb may be high as a result of its narrow inner diameter and length, and thus potentially contribute to an unintended increase in positive end-expiratory pressure (auto-PEEP). We therefore studied the impact of adult sized DLTs on the dynamic auto-PEEP during OLV. In this prospective clinical study, dynamic auto-PEEP was determined in 72 patients undergoing thoracic surgery, with right- and left-sided DLTs of various sizes. During OLV, air trapping was provoked by increasing inspiration to expiration ratio from 1:2 to 2:1 (five steps). Based on measured flow rate, airway pressure (Paw) and bronchial pressure (Pbronch), the pressure gradient across the DLT (ΔPDLT) and the total auto-PEEP in the respiratory system (i.e. the lungs, the DLT and the ventilator circuit) were determined. Subsequently the DLT's share in total auto-PEEP was calculated. ΔPDLT was 2.3 (0.7) cm H2O over the entire breathing cycle. At the shortest expiratory time the mean total auto-PEEP was 2.9 (1.5) cm H2O (range 0-5.9 cm H2O). The DLT caused 27 to 31% of the total auto-PEEP. Size and side of the DLT's bronchial limb did not impact auto-PEEP significantly. Although the DLT contributes to the overall auto-PEEP, its contribution is small and independent of size and side of the DLT's bronchial limb. The choice of DLT does not influence the risk of auto-PEEP during OLV to a clinically relevant extent. DRKS00005648. © The Author 2015. Published by Oxford University Press on behalf of the British Journal of Anaesthesia. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  17. Accuracy of a novel auto-CPAP device to evaluate the residual apnea-hypopnea index in patients with obstructive sleep apnea.

    PubMed

    Nigro, Carlos Alberto; González, Sergio; Arce, Anabella; Aragone, María Rosario; Nigro, Luciana

    2015-05-01

    Patients under treatment with continuous positive airway pressure (CPAP) may have residual sleep apnea (RSA). The main objective of our study was to evaluate a novel auto-CPAP for the diagnosis of RSA. All patients referred to the sleep laboratory to undergo CPAP polysomnography were evaluated. Patients treated with oxygen or noninvasive ventilation and split-night polysomnography (PSG), PSG with artifacts, or total sleep time less than 180 min were excluded. The PSG was manually analyzed before generating the automatic report from auto-CPAP. PSG variables (respiratory disturbance index (RDI), obstructive apnea index, hypopnea index, and central apnea index) were compared with their counterparts from auto-CPAP through Bland-Altman plots and intraclass correlation coefficient. The diagnostic accuracy of autoscoring from auto-CPAP using different cutoff points of RDI (≥5 and 10) was evaluated by the receiver operating characteristics (ROCs) curve. The study included 114 patients (24 women; mean age and BMI, 59 years old and 33 kg/m(2); RDI and apnea/hypopnea index (AHI)-auto median, 5 and 2, respectively). The average difference between the AHI-auto and the RDI was -3.5 ± 3.9. The intraclass correlation coefficient (ICC) between the total number of central apneas, obstructive, and hypopneas between the PSG and the auto-CPAP were 0.69, 0.16, and 0.15, respectively. An AHI-auto >2 (RDI ≥ 5) or >4 (RDI ≥ 10) had an area under the ROC curve, sensitivity, specificity, positive likelihood ratio, and negative for diagnosis of residual sleep apnea of 0.84/0.89, 84/81%, 82/91%, 4.5/9.5, and 0.22/0.2, respectively. The automatic analysis from auto-CPAP (S9 Autoset) showed a good diagnostic accuracy to identify residual sleep apnea. The absolute agreement between PSG and auto-CPAP to classify the respiratory events correctly varied from very low (obstructive apneas, hypopneas) to moderate (central apneas).

  18. Anti-pentraxin 3 auto-antibodies might be protective in lupus nephritis: a large cohort study.

    PubMed

    Yuan, Mo; Tan, Ying; Pang, Yun; Li, Yong-Zhe; Song, Yan; Yu, Feng; Zhao, Ming-Hui

    2017-11-01

    Anti-pentraxin 3 (PTX3) auto-antibodies were found to be associated with the absence of renal involvement in systemic lupus erythematosus (SLE). This study is to investigate the prevalence of anti-PTX3 auto-antibodies and their clinical significance based on a large Chinese lupus nephritis cohort. One hundred and ninety-six active lupus nephritis patients, 150 SLE patients without clinical renal involvement, and 100 healthy controls were enrolled. Serum anti-PTX3 auto-antibodies and PTX3 levels were screened by enzyme-linked immunosorbent assay (ELISA). The associations between anti-PTX3 auto-antibodies and clinicopathological parameters in lupus nephritis were further analyzed. Anti-PTX3 auto-antibodies were less prevalent in active lupus nephritis patients compared with SLE without renal involvement (19.4% (38/196) versus 40.7% (61/150), p < .001). The serum levels of anti-PTX3 auto-antibodies were negatively correlated with proteinuria in lupus nephritis (r = -.143, p = .047). The levels of proteinuria, serum creatinine, and the prevalence of thrombotic microangiopathy were significantly higher in patients with higher PTX3 levels (≥3.207 ng/ml) and without anti-PTX3 auto-antibodies compared with patients with lower PTX3 levels (<3.207 ng/ml) and with anti-PTX3 auto-antibodies (4.79 (3.39-8.28) versus 3.95 (1.78-7.0), p = .03; 168.84 ± 153.63 versus 101.44 ± 47.36, p = .01; 34.1% (14/41) versus 0% (0/9), p = .04; respectively). Anti-PTX3 auto-antibodies were less prevalent in active lupus nephritis patients compared with SLE without renal involvement and associated with less severe renal damage, especially with the combined evaluation of serum PTX3 levels.

  19. Metabolic syndrome and occupation: Any association? Prevalence among auto technicians and school teachers in South West Nigeria.

    PubMed

    Akintunde, Adeseye A; Oloyede, Taiwo W

    2017-11-01

    To determine occupational association with metabolic syndrome among auto technicians and school teachers. One hundred and sixty six subjects were selected for this study. Clinical data was obtained while laboratory investigations including plasma glucose and lipid profile were performed. Statistical analysis was done with SPSS 20.0. P<0.05 was taken as statistically significant. School teachers had significantly higher mean total cholesterol and LDL-cholesterol compared to auto technicians. Mean serum triglycerides was significantly higher among auto-technicians compared to school teachers in this study. The prevalence of some conventional cardiovascular risk factors was significantly higher among auto-technicians compared to school teachers: Impaired blood glucose (9.6% vs. 1.2%, p<0.05), hypertriglyceridaemia (18.1% vs. 7.2%, p<0.05) and low HDL-Cholesterol (47.0% vs. 37.3%, p<0.05) respectively. However elevated LDL-cholesterol (56.6% vs. 32.5%, p<0.05) was significantly more common among school teachers compared to auto-technicians. Based on the WHO and the Harmonized criteria, metabolic syndrome was more frequent among auto-technicians compared to school teachers. (8.4% vs. 1.2% and 19.3% vs. 7.2% respectively, p<0.05) CONCLUSION: The prevalence of metabolic syndrome appears to be significantly higher among auto technicians despite their high level of physical activity, exertion and education compared to teachers. This may be related to the increased occupational exposure to organic and inorganic materials from dust particles, oil and oil related matter and particulate matter among auto technicians. Prompt definitive evaluation of this concept and appropriate health education to encourage safety mechanism can reduce this burden of metabolic syndrome among auto technicians in Nigeria. Copyright © 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.

  20. Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for High-Grade Gliomas in Children and Adolescents

    PubMed Central

    2017-01-01

    With the aim to investigate the outcome of tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) for high-grade gliomas (HGGs), we retrospectively reviewed the medical records of 30 patients with HGGs (16 glioblastomas, 7 anaplastic astrocytomas, and 7 other HGGs) between 2006 and 2015. Gross or near total resection was possible in 11 patients. Front-line treatment after surgery was radiotherapy (RT) in 14 patients and chemotherapy in the remaining 16 patients including 3 patients less than 3 years of age. Eight of 12 patients who remained progression free and 5 of the remaining 18 patients who experienced progression during induction treatment underwent the first HDCT/auto-SCT with carboplatin + thiotepa + etoposide (CTE) regimen and 11 of them proceeded to the second HDCT/auto-SCT with cyclophosphamide + melphalan (CyM) regimen. One patient died from hepatic veno-occlusive disease (VOD) during the second HDCT/auto-SCT; otherwise, toxicities were manageable. Four patients in complete response (CR) and 3 of 7 patients in partial response (PR) or second PR at the first HDCT/auto-SCT remained event free: however, 2 patients with progressive tumor experienced progression again. The probabilities of 3-year overall survival (OS) after the first HDCT/auto-SCT in 11 patients in CR, PR, or second PR was 58.2% ± 16.9%. Tumor status at the first HDCT/auto-SCT was the only significant factor for outcome after HDCT/auto-SCT. There was no difference in survival between glioblastoma and other HGGs. This study suggests that the outcome of HGGs in children and adolescents after HDCT/auto-SCT is encouraging if the patient could achieve CR or PR before HDCT/auto-SCT. PMID:28049229

  1. Post-autologous transplant maintenance therapies in lymphoid malignancies: are we there yet?

    PubMed

    Epperla, N; Fenske, T S; Lazarus, H M; Hamadani, M

    2015-11-01

    Disease relapse after autologous hematopoietic transplant (auto-HCT) remains the number one cause of post-transplant therapy failure and mortality. The last decade has seen a proliferation of clinical studies looking at the prevention of post-auto-HCT therapy failure with various maintenance strategies. The benefit of such therapies is in turn dependent on disease histology and timing of transplantation. Although high dose therapy (HDT) provides durable responses in chemosensitive relapsed diffuse large B-cell lymphoma (DLBCL), a sizable subset experiences disease relapse. Unfortunately, the addition of rituximab as a post-auto-HCT maintenance strategy did not improve survival outcomes. The preliminary results with programmed death -1 (PD-1) Ab as post-auto maintenance in DLBCL is promising but requires randomized validation. In follicular lymphoma, the 5- and 10-year PFS rates are ~60% and 31%, respectively. Although the addition of rituximab improved PFS, there is no survival benefit, to date. Disease relapse after auto-HCT in mantle cell lymphoma (MCL) is not uncommon. Rituximab maintenance in this setting provides a PFS benefit. Given the poor prognosis of post-auto-HCT failures in MCL, maintenance can be considered on a case-by-case basis. In chemosensitive relapsed Hodgkin lymphoma, addition of brentuximab vedotin after auto-HCT improved 2-year PFS (65 vs 45%) and can be considered as an option for maintenance therapy post auto-HCT, in select higher risk patients. Ongoing trials evaluating the efficacy of post-auto-HCT maintenance with novel agents (for example, immunomodulators, proteasome inhibitors, PD-1 inhibitors, Bruton's tyrosine kinase inhibitors and so on) will likely change the practice landscape for lymphoma patients following HDT and auto-HCT.

  2. Impact of single-site axonal GABAergic synaptic events on cerebellar interneuron activity.

    PubMed

    de San Martin, Javier Zorrilla; Jalil, Abdelali; Trigo, Federico F

    2015-12-01

    Axonal ionotropic receptors are present in a variety of neuronal types, and their function has largely been associated with the modulation of axonal activity and synaptic release. It is usually assumed that activation of axonal GABA(A)Rs comes from spillover, but in cerebellar molecular layer interneurons (MLIs) the GABA source is different: in these cells, GABA release activates presynaptic GABA(A) autoreceptors (autoRs) together with postsynaptic targets, producing an autoR-mediated synaptic event. The frequency of presynaptic, autoR-mediated miniature currents is twice that of their somatodendritic counterparts, suggesting that autoR-mediated responses have an important effect on interneuron activity. Here, we used local Ca(2+) photolysis in MLI axons of juvenile rats to evoke GABA release from individual varicosities to study the activation of axonal autoRs in single release sites. Our data show that single-site autoR conductances are similar to postsynaptic dendritic conductances. In conditions of high [Cl(-)](i), autoR-mediated conductances range from 1 to 5 nS; this corresponds to ∼30-150 GABA(A) channels per presynaptic varicosity, a value close to the number of channels in postsynaptic densities. Voltage responses produced by the activation of autoRs in single varicosities are amplified by a Na(v)-dependent mechanism and propagate along the axon with a length constant of 91 µm. Immunolabeling determination of synapse location shows that on average, one third of the synapses produce autoR-mediated signals that are large enough to reach the axon initial segment. Finally, we show that single-site activation of presynaptic GABA(A) autoRs leads to an increase in MLI excitability and thus conveys a strong feedback signal that contributes to spiking activity. © 2015 Zorrilla de San Martin et al.

  3. Impact of single-site axonal GABAergic synaptic events on cerebellar interneuron activity

    PubMed Central

    Zorrilla de San Martin, Javier; Jalil, Abdelali

    2015-01-01

    Axonal ionotropic receptors are present in a variety of neuronal types, and their function has largely been associated with the modulation of axonal activity and synaptic release. It is usually assumed that activation of axonal GABAARs comes from spillover, but in cerebellar molecular layer interneurons (MLIs) the GABA source is different: in these cells, GABA release activates presynaptic GABAA autoreceptors (autoRs) together with postsynaptic targets, producing an autoR-mediated synaptic event. The frequency of presynaptic, autoR-mediated miniature currents is twice that of their somatodendritic counterparts, suggesting that autoR-mediated responses have an important effect on interneuron activity. Here, we used local Ca2+ photolysis in MLI axons of juvenile rats to evoke GABA release from individual varicosities to study the activation of axonal autoRs in single release sites. Our data show that single-site autoR conductances are similar to postsynaptic dendritic conductances. In conditions of high [Cl−]i, autoR-mediated conductances range from 1 to 5 nS; this corresponds to ∼30–150 GABAA channels per presynaptic varicosity, a value close to the number of channels in postsynaptic densities. Voltage responses produced by the activation of autoRs in single varicosities are amplified by a Nav-dependent mechanism and propagate along the axon with a length constant of 91 µm. Immunolabeling determination of synapse location shows that on average, one third of the synapses produce autoR-mediated signals that are large enough to reach the axon initial segment. Finally, we show that single-site activation of presynaptic GABAA autoRs leads to an increase in MLI excitability and thus conveys a strong feedback signal that contributes to spiking activity. PMID:26621773

  4. [Auto-immune disorders as a possible cause of neuropsychiatric syndromes].

    PubMed

    Martinez-Martinez, P; Molenaar, P C; Losen, M; Hoffmann, C; Stevens, J; de Witte, L D; van Amelsvoort, T; van Os, J; Rutten, B P F

    2015-01-01

    Changes that occur in the behaviour of voltage-gated ion channels and ligand-gated receptor channels due to gene mutations or auto-immune attack are the cause of channelopathies in the central and peripheral nervous system. Although the relation between molecular channel defects and clinical symptoms has been explained in the case of many neuromuscular channelopathies, the pathophysiology of auto-immunity in neuropsychiatric syndromes is still unclear. To review recent findings regarding neuronal auto-immune reactions in severe neuropsychiatric syndromes. Using PubMed, we consulted the literature published between 1990 and August 2014 relating to the occurrence of auto-immune antibodies in severe and persistent neuropsychiatric syndromes. Auto-antibodies have only limited access to the central nervous system, but if they do enter the system they can, in some cases, cause disease. We discuss recent findings regarding the occurrence of auto-antibodies against ligand-activated receptor channels and potassium channels in neuropsychiatric and neurological syndromes, including schizophrenia and limbic encephalitis. Although the occurrence of several auto-antibodies in schizophrenia has been confirmed, there is still no proof of a causal relationship in the syndrome. We still have no evidence of the prevalence of auto-immunity in neuropsychiatric syndromes. The discovery that an antibody against an ion channel is associated with some neuropsychiatric disorders may mean that in future it will be possible to treat patients by means of immunosuppression, which could lead to an improvement in a patient's cognitive abilities.

  5. 40 CFR 148.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) HAZARDOUS WASTE INJECTION RESTRICTIONS General § 148.2 Definitions. Injection interval means that part of the injection zone in which the well is screened, or in which the waste is otherwise directly emplaced...

  6. Use of Barriers in Rural Open Road Conditions--A Synthesis Study : [Technical Summary

    DOT National Transportation Integrated Search

    2012-01-01

    Although sufficiently wide medians and clear zones improve : roadside safety, the AASHTO Design Policy allows : for the use of barriers under restricted conditions. Recent : experience with Indianas I-69 corridor challenges : the current design pr...

  7. Stably operating pulse combustor and method

    DOEpatents

    Zinn, Ben T.; Reiner, David

    1990-01-01

    A pulse combustor apparatus adapted to burn either a liquid fuel or a pulverized solid fuel within a preselected volume of the combustion chamber. The combustion process is substantially restricted to an optimum combustion zone in order to attain effective pulse combustion operation.

  8. Permeability of Superpave Mixtures: Evaluation of Field Permeameters

    DOT National Transportation Integrated Search

    1999-02-01

    During the last year all of the states within the southeast have placed Superpave deigned mixtures. Most have been on the coarse side of the restricted zone. Several states have expressed concerns that the Superpave designed pavements are more permea...

  9. Tofacitinib suppresses disease activity and febrile attacks in a patient with coexisting rheumatoid arthritis and familial Mediterranean fever.

    PubMed

    Gök, Kevser; Cengiz, Gizem; Erol, Kemal; Ozgocmen, Salih

    2017-01-01

    Familial Mediterranean fever (FMF) is the most common hereditary auto-inflammatory (periodic fever) syndrome, and usually successfully treated with colchicine. However, nearly 5-10% of FMF cases are resistant or intolerant to colchicine and treatment options are highly restricted in these cases. Biologics including anakinra, canakinumab, rilonacept, etanercept, infliximab, interferon-alpha, and tocilizumab are shown to have efficacy to control FMF attacks. Tofacitinib, a Janus kinase (JAK) inhibitor, is an orally administered non-biologic disease modifying anti-rheumatic drug for the treatment of rheumatoid arthritis (RA). Herein we report a female patient with coexisting RA and colchicine resistant FMF whose FMF attacks and disease activity were completely controlled after treatment with tofacitinib, a small-molecule JAK3 inhibitor.

  10. Estimates of Average Glandular Dose with Auto-modes of X-ray Exposures in Digital Breast Tomosynthesis.

    PubMed

    Kamal, Izdihar; Chelliah, Kanaga K; Mustafa, Nawal

    2015-05-01

    The aim of this research was to examine the average glandular dose (AGD) of radiation among different breast compositions of glandular and adipose tissue with auto-modes of exposure factor selection in digital breast tomosynthesis. This experimental study was carried out in the National Cancer Society, Kuala Lumpur, Malaysia, between February 2012 and February 2013 using a tomosynthesis digital mammography X-ray machine. The entrance surface air kerma and the half-value layer were determined using a 100H thermoluminescent dosimeter on 50% glandular and 50% adipose tissue (50/50) and 20% glandular and 80% adipose tissue (20/80) commercially available breast phantoms (Computerized Imaging Reference Systems, Inc., Norfolk, Virginia, USA) with auto-time, auto-filter and auto-kilovolt modes. The lowest AGD for the 20/80 phantom with auto-time was 2.28 milliGray (mGy) for two dimension (2D) and 2.48 mGy for three dimensional (3D) images. The lowest AGD for the 50/50 phantom with auto-time was 0.97 mGy for 2D and 1.0 mGy for 3D. The AGD values for both phantoms were lower against a high kilovolt peak and the use of auto-filter mode was more practical for quick acquisition while limiting the probability of operator error.

  11. What factors affect the carriage of epinephrine auto-injectors by teenagers?

    PubMed Central

    2012-01-01

    Background Teenagers with allergies are at particular risk of severe and fatal reactions, but epinephrine auto-injectors are not always carried as prescribed. We investigated barriers to carriage. Methods Patients aged 12-18 years old under a specialist allergy clinic, who had previously been prescribed an auto-injector were invited to participate. Semi-structured interviews explored the factors that positively or negatively impacted on carriage. Results Twenty teenagers with food or venom allergies were interviewed. Only two patients had used their auto-injector in the community, although several had been treated for severe reactions in hospital. Most teenagers made complex risk assessments to determine whether to carry the auto-injector. Most but not all decisions were rational and were at least partially informed by knowledge. Factors affecting carriage included location, who else would be present, the attitudes of others and physical features of the auto-injector. Teenagers made frequent risk assessments when deciding whether to carry their auto-injectors, and generally wanted to remain safe. Their decisions were complex, multi-faceted and highly individualised. Conclusions Rather than aiming for 100% carriage of auto-injectors, which remains an ambitious ideal, personalised education packages should aim to empower teenagers to make and act upon informed risk assessments. PMID:22409884

  12. Phenotypic modulation of auto-reactive cells by insertion of tolerogenic molecules via MSC-derived exosomes.

    PubMed

    Mokarizadeh, Aram; Delirezh, Nowruz; Morshedi, Ahhmad; Mosayebi, Ghasem; Farshid, Amir-Abbas; Dalir-Naghadeh, Bahram

    2012-01-01

    Auto-reactive cells-mediated immune responses are responsible for the current tissue damages during autoimmunity. Accordingly, functional modulation of auto-reactive cells has been a pivotal aim in many of recent studies. In the current study, we investigated the possibility for insertion of regulatory molecules onto auto-reactive cells through exosomal nano-shuttles as a novel approach for phenotype modification of auto-reactive cells. The exosomes were isolated from supernatant of mesenchymal stem cells culture. Resultant exosomes co-cultured with lymphocytes were harvested from established EAE mice in the presence of antigenic MOG35-55 peptide. After 24 hr, insertion of exosomal tolerogenic molecules (PD-L1, TGF-β, galectin-1) onto auto-reactive cells were explored through flow cytometry. The potency of exosomal inserted membrane molecules to modulate phenotype of auto-reactive lymphocytes was assessed upon ELISA test for their-derived cytokines IFN-γ and IL-17. Incorporation of exosomal molecules into lymohocytes' membrane was confirmed by flow cytometric analyses for surface levels of mentioned molecules. Additionally, the decreased secretion of IFN-γ and IL-17 were detected in exosome pre-treated lymphocytes upon stimulation with MOG peptide. Mesenchymal stem cells -derived exosomes showed to be efficient organelles for insertion of bioactive tolerogenic molecules onto auto-reactive cells and modulation of their phenotypes.

  13. Hydrogeological impacts of a railway tunnel in fractured Precambrian gneiss rocks (south-eastern Norway)

    NASA Astrophysics Data System (ADS)

    Kværner, Jens; Snilsberg, Petter

    2013-11-01

    Groundwater monitoring along the Romeriksporten tunnel, south-eastern Norway, provided an opportunity for studying the impacts of tunnelling on groundwater in fractured Precambrian gneiss rocks, and examining relations between bedrock hydrology, tectonic weakness zones and catchments. Tunnel leakage resulted in groundwater drawdown up to 35 m in weakness zones, converted groundwater discharge zones into recharge zones, and affected groundwater chemistry. The magnitude of drawdown and fluctuations in groundwater level differed between weakness zones, and varied with distance from the tunnel route, tunnel leakage, and recharge from catchments. Clear differences in groundwater level and fluctuation patterns indicated restricted groundwater flow between weakness zones. The groundwater drawdowns demonstrated coherent water-bearing networks to 180-m depth in faults and fracture zones. Similar groundwater levels with highly correlated fluctuations demonstrated hydraulic connectivity within fracture zones. Different groundwater drawdown and leakage in weakness zones with different appearance and influence of tectonic events demonstrated the importance of the geological history for bedrock hydrogeology. Water injection into the bedrock counteracted groundwater drawdowns. Even moderate leakage to underground constructions may lead to large groundwater drawdown in areas with small groundwater recharge. Hydrogeological interpretation of tectonic weakness zones should occur in the context of geological history and local catchment hydrology.

  14. Auto-Regulatory RNA Editing Fine-Tunes mRNA Re-Coding and Complex Behaviour in Drosophila

    PubMed Central

    Savva, Yiannis A.; Jepson, James E.C; Sahin, Asli; Sugden, Arthur U.; Dorsky, Jacquelyn S.; Alpert, Lauren; Lawrence, Charles; Reenan, Robert A.

    2014-01-01

    Auto-regulatory feedback loops are a common molecular strategy used to optimize protein function. In Drosophila many mRNAs involved in neuro-transmission are re-coded at the RNA level by the RNA editing enzyme dADAR, leading to the incorporation of amino acids that are not directly encoded by the genome. dADAR also re-codes its own transcript, but the consequences of this auto-regulation in vivo are unclear. Here we show that hard-wiring or abolishing endogenous dADAR auto-regulation dramatically remodels the landscape of re-coding events in a site-specific manner. These molecular phenotypes correlate with altered localization of dADAR within the nuclear compartment. Furthermore, auto-editing exhibits sexually dimorphic patterns of spatial regulation and can be modified by abiotic environmental factors. Finally, we demonstrate that modifying dAdar auto-editing affects adaptive complex behaviors. Our results reveal the in vivo relevance of auto-regulatory control over post-transcriptional mRNA re-coding events in fine-tuning brain function and organismal behavior. PMID:22531175

  15. Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation

    PubMed Central

    Cohen, Todd J.; Constance, Brian H.; Hwang, Andrew W.; James, Michael; Yuan, Chao-Xing

    2016-01-01

    Tau proteins are abnormally aggregated in a range of neurodegenerative tauopathies including Alzheimer’s disease (AD). Recently, tau has emerged as an extensively post-translationally modified protein, among which lysine acetylation is critical for normal tau function and its pathological aggregation. Here, we demonstrate that tau isoforms have different propensities to undergo lysine acetylation, with auto-acetylation occurring more prominently within the lysine-rich microtubule-binding repeats. Unexpectedly, we identified a unique intrinsic property of tau in which auto-acetylation induces proteolytic tau cleavage, thereby generating distinct N- and C-terminal tau fragments. Supporting a catalytic reaction-based mechanism, mapping and mutagenesis studies showed that tau cysteines, which are required for acetyl group transfer, are also essential for auto-proteolytic tau processing. Further mass spectrometry analysis identified the C-terminal 2nd and 4th microtubule binding repeats as potential sites of auto-cleavage. The identification of acetylation-mediated auto-proteolysis provides a new biochemical mechanism for tau self-regulation and warrants further investigation into whether auto-catalytic functions of tau are implicated in AD and other tauopathies. PMID:27383765

  16. Auto-phosphorylation Represses Protein Kinase R Activity.

    PubMed

    Wang, Die; de Weerd, Nicole A; Willard, Belinda; Polekhina, Galina; Williams, Bryan R G; Sadler, Anthony J

    2017-03-10

    The central role of protein kinases in controlling disease processes has spurred efforts to develop pharmaceutical regulators of their activity. A rational strategy to achieve this end is to determine intrinsic auto-regulatory processes, then selectively target these different states of kinases to repress their activation. Here we investigate auto-regulation of the innate immune effector protein kinase R, which phosphorylates the eukaryotic initiation factor 2α to inhibit global protein translation. We demonstrate that protein kinase R activity is controlled by auto-inhibition via an intra-molecular interaction. Part of this mechanism of control had previously been reported, but was then controverted. We account for the discrepancy and extend our understanding of the auto-inhibitory mechanism by identifying that auto-inhibition is paradoxically instigated by incipient auto-phosphorylation. Phosphor-residues at the amino-terminus instigate an intra-molecular interaction that enlists both of the N-terminal RNA-binding motifs of the protein with separate surfaces of the C-terminal kinase domain, to co-operatively inhibit kinase activation. These findings identify an innovative mechanism to control kinase activity, providing insight for strategies to better regulate kinase activity.

  17. Intrinsic Tau Acetylation Is Coupled to Auto-Proteolytic Tau Fragmentation.

    PubMed

    Cohen, Todd J; Constance, Brian H; Hwang, Andrew W; James, Michael; Yuan, Chao-Xing

    2016-01-01

    Tau proteins are abnormally aggregated in a range of neurodegenerative tauopathies including Alzheimer's disease (AD). Recently, tau has emerged as an extensively post-translationally modified protein, among which lysine acetylation is critical for normal tau function and its pathological aggregation. Here, we demonstrate that tau isoforms have different propensities to undergo lysine acetylation, with auto-acetylation occurring more prominently within the lysine-rich microtubule-binding repeats. Unexpectedly, we identified a unique intrinsic property of tau in which auto-acetylation induces proteolytic tau cleavage, thereby generating distinct N- and C-terminal tau fragments. Supporting a catalytic reaction-based mechanism, mapping and mutagenesis studies showed that tau cysteines, which are required for acetyl group transfer, are also essential for auto-proteolytic tau processing. Further mass spectrometry analysis identified the C-terminal 2nd and 4th microtubule binding repeats as potential sites of auto-cleavage. The identification of acetylation-mediated auto-proteolysis provides a new biochemical mechanism for tau self-regulation and warrants further investigation into whether auto-catalytic functions of tau are implicated in AD and other tauopathies.

  18. Auto-fusion and the shaping of neurons and tubes

    PubMed Central

    Soulavie, Fabien; Sundaram, Meera V.

    2016-01-01

    Cells adopt specific shapes that are necessary for specific functions. For example, some neurons extend elaborate arborized dendrites that can contact multiple targets. Epithelial and endothelial cells can form tiny seamless unicellular tubes with an intracellular lumen. Recent advances showed that cells can auto-fuse to acquire those specific shapes. During auto-fusion, a cell merges two parts of its own plasma membrane. In contrast to cell-cell fusion or macropinocytic fission, which result in the merging or formation of two separate membrane bound compartments, auto-fusion preserves one compartment, but changes its shape. The discovery of auto-fusion in C. elegans was enabled by identification of specific protein fusogens, EFF-1 and AFF-1, that mediate cell-cell fusion. Phenotypic characterization of eff-1 and aff-1 mutants revealed that fusogen-mediated fusion of two parts of the same cell can be used to sculpt dendritic arbors, reconnect two parts of an axon after injury, or form a hollow unicellular tube. Similar auto-fusion events recently were detected in vertebrate cells, suggesting that auto-fusion could be a widely used mechanism for shaping neurons and tubes. PMID:27436685

  19. 13C multiplet nuclear magnetic resonance relaxation-derived ring puckering and backbone dynamics in proline-containing glycine-based peptides.

    PubMed Central

    Mikhailov, D; Daragan, V A; Mayo, K H

    1995-01-01

    13CH2-multiplet nuclear magnetic resonance relaxation studies on proline (P)-containing glycine (G)-based peptides, GP, PG, GPG, PGG, and GPGG, provided numerous dipolar auto- and cross-correlation times for various motional model analyses of backbone and proline-ring bond rotations. Molecular dynamics simulations and bond rotation energy profiles were calculated to assess which motions could contribute most to observed relaxation phenomena. Results indicate that proline restricts backbone psi 1, psi 2, and phi 2 motions by 50% relative to those found for a polyglycine control peptide. psi 1 rotations are more restricted in the trans-proline isomer state than in the cis form. A two-state jump model best approximates proline ring puckering which in water could occur either by the C gamma endo-exo or by the C2 interconversion mechanism. The temperature dependence (5 degrees to 75 degrees C) of C beta, and C gamma, and C delta angular changes is rather flat, suggesting a near zero enthalpic contribution to the ring puckering process. In lower dielectric solvents, dimethylsulfoxide and methanol, which may mimic the hydrophobic environment within a protein, the endo-exo mechanism is preferred. PMID:7787039

  20. Two-layer contractive encodings for learning stable nonlinear features.

    PubMed

    Schulz, Hannes; Cho, Kyunghyun; Raiko, Tapani; Behnke, Sven

    2015-04-01

    Unsupervised learning of feature hierarchies is often a good strategy to initialize deep architectures for supervised learning. Most existing deep learning methods build these feature hierarchies layer by layer in a greedy fashion using either auto-encoders or restricted Boltzmann machines. Both yield encoders which compute linear projections of input followed by a smooth thresholding function. In this work, we demonstrate that these encoders fail to find stable features when the required computation is in the exclusive-or class. To overcome this limitation, we propose a two-layer encoder which is less restricted in the type of features it can learn. The proposed encoder is regularized by an extension of previous work on contractive regularization. This proposed two-layer contractive encoder potentially poses a more difficult optimization problem, and we further propose to linearly transform hidden neurons of the encoder to make learning easier. We demonstrate the advantages of the two-layer encoders qualitatively on artificially constructed datasets as well as commonly used benchmark datasets. We also conduct experiments on a semi-supervised learning task and show the benefits of the proposed two-layer encoders trained with the linear transformation of perceptrons. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. Microstructure evolution in the fusion zone of laser-welded Mg–Gd–Y–Zr alloy during solution and aging treatment

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Lyuyuan

    The microstructure evolution in the fusion zone of laser-welded Mg-Gd-Y-Zr alloy during solution and aging treatment is investigated. The morphology of the Mg{sub 24}(Gd,Y){sub 5} in the divorced eutectic at the grain boundary transforms from a continuous network to disconnected and fragmentized islands and then to spheroidal particles before complete dissolution during the solution treatment at 430 °C. During the subsequent aging treatment at 225 °C, the precipitation sequence in the fusion zone follows the order of supersaturated solid solution (SSSS) → βʺ(D0{sub 19}) → βʹ(cbco) → β{sub 1}(fcc) → β(fcc). High-density precipitates are present at the original grain boundariesmore » of the fusion zone from the welded structure but there are less precipitates in the interior of the original grains. The grain growth during the solution treatment at 430 °C comprises the slowly increasing stage, rapidly increasing stage, and stable stage. The network-distributed Mg{sub 24}(Gd,Y){sub 5} impedes migration of the grain boundaries, restricts grain growth in the first slowly increasing stage, and segregation of zirconium near the grain boundaries also affects migration of the grain boundaries. - Highlights: •Different quantities of precipitates are present at different location of grain. •The network-distributed Mg{sub 24}(Gd,Y){sub 5} restricts grain growth. •Segregation of Zr affects migration of grain boundaries.« less

  2. The Usefulness of Zone Division Using Belt Partition at the Entry Zone of MRI Machine Room: An Analysis of the Restrictive Effect of Dangerous Action Using a Questionnaire.

    PubMed

    Funada, Tatsuro; Shibuya, Tsubasa

    2016-08-01

    The American College of Radiology recommends dividing magnetic resonance imaging (MRI) machine rooms into four zones depending on the education level. However, structural limitations restrict us to apply such recommendation in most of the Japanese facilities. This study examines the effectiveness of the usage of a belt partition to create the zonal division by a questionnaire survey including three critical parameters. They are, the influence of individuals' background (relevance to MRI, years of experience, individuals' post, occupation [i.e., nurse or nursing assistant], outpatient section or ward), the presence or absence of a door or belt partition (opening or closing), and any four personnel scenarios that may be encountered during a visit to an MRI site (e.g., from visiting the MRI site to receive a patient) . In this survey, the influence of dangerous action is uncertain on individuals' backgrounds (maximum odds ratio: 6.3, 95% CI: 1.47-27.31) and the scenarios of personnel (maximum risk ratio: 2.4, 95% CI: 1.16-4.85). Conversely, the presence of the door and belt partition influences significantly (maximum risk ratio: 17.4, 95% CI: 7.94-17.38). For that reason, we suggest that visual impression has a strong influence on an individuals' actions. Even if structural limitations are present, zonal division by belt partition will provide a visual deterrent. Then, the partitioned zone will serve as a buffer zone. We conclude that if the belt partition is used properly, it is an inexpensive and effective safety management device for MRI rooms.

  3. An Angus/Argo study of the neovolcanic zone along the East Pacific rise from the Clipperton fracture zone to 12°N

    USGS Publications Warehouse

    Uchupi, E.; Schwab, W.C.; Ballard, Richard D.; Cheminee, J.L.; Francheteau, Jean; Hekinian, R.; Blackman, D.K.; Sigurdsson, Haraldur

    1988-01-01

    Still photographs and video images collected along the Neovolcanic Zone of the East Pacific Rise from 10°15′N to 11°53′N show that recent volcanic sheet flows, possibly less than 100 years old, are superimposed on an older sediment-laden pillow terrane. This recent activity is restricted to a narrow zone that crosses two topographic highs at 10°55′N and 11°26′N and diminishes along-axis away from these highs. The association of recent sheet flows with older flows and collapse structures on the overlapping spreading centers at 11°45′N supports the evolutionary model for the occurrence and evolution of overlapping spreading centers by MacDonald and others (1986, 1988).

  4. Sensitivity to external signals and synchronization properties of a non-isochronous auto-oscillator with delayed feedback

    PubMed Central

    Tiberkevich, Vasil S.; Khymyn, Roman S.; Tang, Hong X.; Slavin, Andrei N.

    2014-01-01

    For auto-oscillators of different nature (e.g. active cells in a human heart under the action of a pacemaker, neurons in brain, spin-torque nano-oscillators, micro and nano-mechanical oscillators, or generating Josephson junctions) a critically important property is their ability to synchronize with each other. The synchronization properties of an auto oscillator are directly related to its sensitivity to external signals. Here we demonstrate that a non-isochronous (having generation frequency dependent on the amplitude) auto-oscillator with delayed feedback can have an extremely high sensitivity to external signals and unusually large width of the phase-locking band near the boundary of the stable auto-oscillation regime. This property could be used for the development of synchronized arrays of non-isochronous auto-oscillators in physics and engineering, and, for instance, might bring a better fundamental understanding of ways to control a heart arrythmia in medicine. PMID:24464086

  5. AutoLock: a semiautomated system for radiotherapy treatment plan quality control

    PubMed Central

    Lowe, Matthew; Hardy, Mark J.; Boylan, Christopher J.; Whitehurst, Philip; Rowbottom, Carl G.

    2015-01-01

    A semiautomated system for radiotherapy treatment plan quality control (QC), named AutoLock, is presented. AutoLock is designed to augment treatment plan QC by automatically checking aspects of treatment plans that are well suited to computational evaluation, whilst summarizing more subjective aspects in the form of a checklist. The treatment plan must pass all automated checks and all checklist items must be acknowledged by the planner as correct before the plan is finalized. Thus AutoLock uniquely integrates automated treatment plan QC, an electronic checklist, and plan finalization. In addition to reducing the potential for the propagation of errors, the integration of AutoLock into the plan finalization workflow has improved efficiency at our center. Detailed audit data are presented, demonstrating that the treatment plan QC rejection rate fell by around a third following the clinical introduction of AutoLock. PACS number: 87.55.Qr PMID:26103498

  6. AutoLock: a semiautomated system for radiotherapy treatment plan quality control.

    PubMed

    Dewhurst, Joseph M; Lowe, Matthew; Hardy, Mark J; Boylan, Christopher J; Whitehurst, Philip; Rowbottom, Carl G

    2015-05-08

    A semiautomated system for radiotherapy treatment plan quality control (QC), named AutoLock, is presented. AutoLock is designed to augment treatment plan QC by automatically checking aspects of treatment plans that are well suited to computational evaluation, whilst summarizing more subjective aspects in the form of a checklist. The treatment plan must pass all automated checks and all checklist items must be acknowledged by the planner as correct before the plan is finalized. Thus AutoLock uniquely integrates automated treatment plan QC, an electronic checklist, and plan finalization. In addition to reducing the potential for the propagation of errors, the integration of AutoLock into the plan finalization workflow has improved efficiency at our center. Detailed audit data are presented, demonstrating that the treatment plan QC rejection rate fell by around a third following the clinical introduction of AutoLock.

  7. Numerical Analysis of the Interaction between Thermo-Fluid Dynamics and Auto-Ignition Reaction in Spark Ignition Engines

    NASA Astrophysics Data System (ADS)

    Saijyo, Katsuya; Nishiwaki, Kazuie; Yoshihara, Yoshinobu

    The CFD simulations were performed integrating the low-temperature oxidation reaction. Analyses were made with respect to the first auto-ignition location in the case of a premixed-charge compression auto-ignition in a laminar flow field and in the case of the auto-ignition in an end gas during an S. I. Engine combustion process. In the latter simulation, the spatially-filtered transport equations were solved to express fluctuating temperatures in a turbulent flow in consideration of strong non-linearity to temperature in the reaction equations. It is suggested that the first auto-ignition location does not always occur at higher-temperature locations and that the difference in the locations of the first auto-ignition depends on the time period during which the local end gas temperature passes through the region of shorter ignition delay, including the NTC region.

  8. 75 FR 32855 - Safety Zone; Pierce County, WA, Department of Emergency Management, Regional Water Exercise

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-10

    ... restricting deep draft vessels from creating a wake near the exercise. DATES: This rule is effective from 7 a... exercise area, and from creating large wakes near the exercise. Discussion of Rule This rule establishes a...

  9. 33 CFR 334.78 - Rhode Island Sound, Atlantic Ocean, approximately 4.0 nautical miles due south of Lands End in...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.78 Rhode... sonar. Neither variable depth sonar devices or mechanical minesweeping operations will be utilized in...

  10. 33 CFR 334.1190 - Hood Canal and Dabob Bay, Wash.; naval non-explosive torpedo testing area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA... the area. (iii) No vessel shall anchor in the area except between the shore and the 10-fathom depth...

  11. 33 CFR 334.78 - Rhode Island Sound, Atlantic Ocean, approximately 4.0 nautical miles due south of Lands End in...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.78 Rhode... sonar. Neither variable depth sonar devices or mechanical minesweeping operations will be utilized in...

  12. 33 CFR 334.1190 - Hood Canal and Dabob Bay, Wash.; naval non-explosive torpedo testing area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA... the area. (iii) No vessel shall anchor in the area except between the shore and the 10-fathom depth...

  13. 14 CFR 151.26 - Procedures: Applications; compatible land use information; consideration of local community...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... aerial approaches; (2) Any zoning laws enacted or in force restricting the use of land adjacent to or in... replacement housing that is open to all persons, regardless of race, color, religion, sex, or national origin...

  14. AutoGen Version 5.0

    NASA Technical Reports Server (NTRS)

    Gladden, Roy E.; Khanampornpan, Teerapat; Fisher, Forest W.

    2010-01-01

    Version 5.0 of the AutoGen software has been released. Previous versions, variously denoted Autogen and autogen, were reported in two articles: Automated Sequence Generation Process and Software (NPO-30746), Software Tech Briefs (Special Supplement to NASA Tech Briefs), September 2007, page 30, and Autogen Version 2.0 (NPO- 41501), NASA Tech Briefs, Vol. 31, No. 10 (October 2007), page 58. To recapitulate: AutoGen (now signifying automatic sequence generation ) automates the generation of sequences of commands in a standard format for uplink to spacecraft. AutoGen requires fewer workers than are needed for older manual sequence-generation processes, and greatly reduces sequence-generation times. The sequences are embodied in spacecraft activity sequence files (SASFs). AutoGen automates generation of SASFs by use of another previously reported program called APGEN. AutoGen encodes knowledge of different mission phases and of how the resultant commands must differ among the phases. AutoGen also provides means for customizing sequences through use of configuration files. The approach followed in developing AutoGen has involved encoding the behaviors of a system into a model and encoding algorithms for context-sensitive customizations of the modeled behaviors. This version of AutoGen addressed the MRO (Mars Reconnaissance Orbiter) primary science phase (PSP) mission phase. On previous Mars missions this phase has more commonly been referred to as mapping phase. This version addressed the unique aspects of sequencing orbital operations and specifically the mission specific adaptation of orbital operations for MRO. This version also includes capabilities for MRO s role in Mars relay support for UHF relay communications with the MER rovers and the Phoenix lander.

  15. Next-Generation Autoantibody Testing by Combination of Screening and Confirmation-the CytoBead® Technology.

    PubMed

    Sowa, Mandy; Hiemann, Rico; Schierack, Peter; Reinhold, Dirk; Conrad, Karsten; Roggenbuck, Dirk

    2017-08-01

    Occurrence of autoantibodies (autoAbs) is a hallmark of autoimmune diseases, and the analysis thereof is an essential part in the diagnosis of organ-specific autoimmune and systemic autoimmune rheumatic diseases (SARD), especially connective tissue diseases (CTDs). Due to the appearance of autoAb profiles in SARD patients and the complexity of the corresponding serological diagnosis, different diagnostic strategies have been suggested for appropriate autoAb testing. Thus, evolving assay techniques and the continuous discovery of novel autoantigens have greatly influenced the development of these strategies. Antinuclear antibody (ANA) analysis by indirect immunofluorescence (IIF) on tissue and later cellular substrates was one of the first tests introduced into clinical routine and is still an indispensable tool for CTD serology. Thus, screening for ANA by IIF is recommended to be followed by confirmatory testing of positive findings employing different assay techniques. Given the continuous growth in the demand for autoAb testing, IIF has been challenged as the standard method for ANA and other autoAb analyses due to lacking automation, standardization, modern data management, and human bias in IIF pattern interpretation. To address these limitations of autoAb testing, the CytoBead® technique has been introduced recently which enables automated interpretation of cell-based IIF and quantitative autoAb multiplexing by addressable microbead immunoassays in one reaction environment. Thus, autoAb screening and confirmatory testing can be combined for the first time. The present review discusses the history of autoAb assay techniques in this context and gives an overview and outlook of the recent progress in emerging technologies.

  16. 49 CFR Appendix A to Part 544 - Issuers of Motor Vehicle Insurance Policies Subject to the Reporting Requirements in Each State...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Group Auto Club Enterprise Insurance Group Auto-Owners Insurance Group Berkshire Hathaway/GEICO... Insurance Companies Metropolitan Life Auto & Home Group Mercury General Group Nationwide Group Progressive...

  17. 49 CFR Appendix A to Part 544 - Issuers of Motor Vehicle Insurance Policies Subject to the Reporting Requirements in Each State...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Group Auto Club Enterprise Insurance Group Auto-Owners Insurance Group Berkshire Hathaway/GEICO... Insurance Companies Metropolitan Life Auto & Home Group Mercury General Group Nationwide Group Progressive...

  18. Accuracy of autotitrating CPAP to estimate the residual Apnea-Hypopnea Index in patients with obstructive sleep apnea on treatment with autotitrating CPAP.

    PubMed

    Desai, Himanshu; Patel, Anil; Patel, Pinal; Grant, Brydon J B; Mador, M Jeffery

    2009-11-01

    Autotitrating continuous positive airway pressure (auto-CPAP) devices now have a smart card (a pocket-sized card with embedded integrated circuits which records data from the CPAP machine such as CPAP usage, CPAP pressure, large leak, etc.) which can estimate the Apnea-Hypopnea Index (AHI) on therapy. The aim of this study was to determine the accuracy of auto-CPAP in estimating the residual AHI in patients with obstructive sleep apnea (OSA) who were treated with auto-CPAP without a CPAP titration study. We studied 99 patients with OSA from April 2005 to May 2007 who underwent a repeat sleep study using auto-CPAP. The estimated AHI from auto-CPAP was compared with the AHI from an overnight polysomnogram (PSG) on auto-CPAP using Bland-Altman plot and likelihood ratio analyses. A PSG AHI cutoff of five events per hour was used to differentiate patients optimally treated with auto-CPAP from those with residual OSA on therapy. Bland and Altman analysis showed good agreement between auto-CPAP AHI and PSG AHI. There was no significant bias when smart card estimates of AHI at home were compared to smart card estimates obtained in the sleep laboratory. An auto-CPAP cutoff for the AHI of six events per hour was shown to be optimal for differentiating patients with and without residual OSA with a sensitivity of 0.92 (95% confidence interval (CI) 0.76 to 0.98) and specificity of 0.90 (95% CI 0.82 to 0.95) with a positive likelihood ratio (LR) of 9.6 (95% CI 5.1 to 21.5) and a negative likelihood ratio of 0.085 (95% CI 0.02 to 0.25). Auto-CPAP AHI of eight events per hour yielded the optimal sensitivity (0.94, 95% CI 0.73 to 0.99) and specificity (0.90, 95% CI 0.82 to 0.95) with a positive LR of 9.6 (95% CI 5.23 to 20.31) and a negative LR of 0.065 (95% CI 0.004 to 0.279) to identify patients with a PSG AHI of > or = 10 events per hour. Auto-CPAP estimate of AHI may be used to estimate residual AHI in patients with OSA of varying severity treated with auto-CPAP.

  19. Autonomous Formation Flying from Ground to Flight

    NASA Technical Reports Server (NTRS)

    Chapman, Keith B.; Dell, Gregory T.; Rosenberg, Duane L.; Bristow, John

    1999-01-01

    The cost of on-orbit operations remains a significant and increasingly visible concern in the support of satellite missions. Headway has been made in automating some ground operations; however, increased mission complexity and more precise orbital constraints have compelled continuing human involvement in mission design and maneuver planning operations. AI Solutions, Inc. in cooperation with the National Aeronautics and Space Administration's (NASA) Goddard Space Flight Center (GSFC) has tackled these more complex problems through the development of AutoCon as a tool for an automated solution. NASA is using AutoCon to automate the maneuver planning for the Earth Orbiter-1 (EO-1) mission. AutoCon was developed originally as a ground system tool. The EO-1 mission will be using a scaled version of AutoCon on-board the EO-1 satellite to command orbit adjustment maneuvers. The flight version of AutoCon plans maneuvers based on formation flying algorithms developed by GSFC, JPL, and other industry partners. In its fully autonomous mode, an AutoCon planned maneuver will be executed on-board the satellite without intervention from the ground. This paper describes how AutoCon automates maneuver planning for the formation flying constraints of the EO-1 mission. AutoCon was modified in a number of ways to automate the maneuver planning on-board the satellite. This paper describes how the interface and functionality of AutoCon were modified to support the on-board system. A significant component of this modification was the implementation of a data smoother, based on a Kalman filter, that ensures that the spacecraft states estimated by an on-board GPS receiver are as accurate as possible for maneuver planning. This paper also presents the methodology use to scale the AutoCon functionality to fit and execute on the flight hardware. This paper also presents the modes built that allow the incremental phasing in of autonomy. New technologies for autonomous operations are usually received with significant, and probably appropriate trepidation. A number of safeguards have been designed in both AutoCon and the interfacing systems to alleviate the potential of mission-impacting anomalies from the on-board autonomous system. This paper describes the error checking, input data integrity validation and limits set on maneuvers in AutoCon and the on-board system.

  20. Autonomous Formation Flying from the Ground to Flight

    NASA Technical Reports Server (NTRS)

    Chapman, Keith B.; Dell, Gregory T.; Rosenberg, Duane L.; Bristow, John

    1999-01-01

    The cost of on-orbit operations remains a significant and increasingly visible concern in the support of satellite missions. Headway has been made in automating some ground operations; however, increased mission complexity and more precise orbital constraints have compelled continuing human involvement in mission design and maneuver planning operations. AI Solutions, Inc. in cooperation with the National Aeronautics and Space Administration's (NASA) Goddard Space Flight Center (GSFC) has tackled these more complex problems through the development of AutoCon(TM) as a tool for an automated solution. NASA is using AutoCon(TM) to automate the maneuver planning for the Earth Orbiter-1 (EO-1) mission. AutoCon(TM) was developed originally as a ground system tool. The EO-1 mission will be using a scaled version of AutoCon(TM) on-board the EO-1 satellite to command orbit adjustment maneuvers. The flight version of AutoCon(TM) plans maneuvers based on formation flying algorithms developed by GSFC, JPL, and other industry partners. In its fully autonomous mode, an AutoCon(TM) planned maneuver will be executed on-board the satellite without intervention from the ground. This paper describes how AutoCon(TM) automates maneuver planning for the formation flying constraints of the EO-1 mission. AutoCon(TM) was modified in a number of ways to automate the maneuver planning on-board the satellite. This paper describes how the interface and functionality of AutoCon(TM) were modified to support the on-board system. A significant component of this modification was the implementation of a data smoother, based on a Kalman filter, that ensures that the spacecraft states estimated by an on-board GPS receiver are as accurate as possible for maneuver planning. This paper also presents the methodology used to scale the AutoCon(TM) functionality to fit and execute on the flight hardware. This paper also presents the modes built into the system that allow the incremental phasing in of autonomy. New technologies for autonomous operations are usually received with significant, and probably appropriate, trepidation. A number of safeguards have been designed in both AutoCon(TM) and the interfacing systems to alleviate the potential of mission-impacting anomalies from the on-board autonomous system. This paper describes the error checking, input data integrity validation, and limits set on maneuvers in AutoCon(TM) and the on-board system.

  1. Hemodynamic responses to external counterbalancing of auto-positive end-expiratory pressure in mechanically ventilated patients with chronic obstructive pulmonary disease.

    PubMed

    Baigorri, F; de Monte, A; Blanch, L; Fernández, R; Vallés, J; Mestre, J; Saura, P; Artigas, A

    1994-11-01

    To study the effect of positive end-expiratory pressure (PEEP) on right ventricular hemodynamics and ejection fraction in patients with chronic obstructive pulmonary disease and positive alveolar pressure throughout expiration by dynamic hyperinflation (auto-PEEP). Open, prospective, controlled trial. General intensive care unit of a community hospital. Ten patients sedated and paralyzed with an acute exacerbation of chronic obstructive pulmonary disease undergoing mechanical ventilation. Insertion of a pulmonary artery catheter modified with a rapid response thermistor and a radial arterial catheter. PEEP was then increased from 0 (PEEP 0) to auto-PEEP level (PEEP = auto-PEEP) and 5 cm H2O above that (PEEP = auto-PEEP +5). At each level of PEEP, airway pressures, flow and volume, hemodynamic variables (including right ventricular ejection fraction by thermodilution technique), and blood gas analyses were recorded. The mean auto-PEEP was 6.6 +/- 2.8 cm H2O and the total PEEP reached was 12.2 +/- 2.4 cm H2O. The degree of lung inflation induced by PEEP averaged 145 +/- 87 mL with PEEP = auto-PEEP and 495 +/- 133 mL with PEEP = auto-PEEP + 5. The PEEP = auto-PEEP caused a right ventricular end-diastolic pressure increase, but there was no other significant hemodynamic change. With PEEP = auto-PEEP + 5, there was a significant increase in intravascular pressures; this amount of PEEP reduced cardiac output (from 4.40 +/- 1.38 L/min at PEEP 0 to 4.13 +/- 1.48 L/min; p < .05). The cardiac output reduction induced by PEEP = auto-PEEP + 5 was > 10% in only five cases and this group of patients had significantly lower right ventricular volumes than the group with less cardiac output variation (right ventricular end-diastolic volume: 64 +/- 9 vs. 96 +/- 26 mL/m2; right ventricular end-systolic volume: 38 +/- 6 vs. 65 +/- 21 mL/m2; p < .05) without significant difference in the other variables that were measured. Neither right ventricular ejection fraction nor right ventricle volumes changed as PEEP increased, but there were marked interpatient differences and also pronounced changes in volume between stages in individual patients. In the study conditions, PEEP application up to values approaching auto-PEEP did not result in the impairment of right ventricular hemodynamics, while higher levels reduced cardiac output in selected patients.

  2. [DNA Extraction from Old Bones by AutoMate Express™ System].

    PubMed

    Li, B; Lü, Z

    2017-08-01

    To establish a method for extracting DNA from old bones by AutoMate Express™ system. Bones were grinded into powder by freeze-mill. After extraction by AutoMate Express™, DNA were amplified and genotyped by Identifiler®Plus and MinFiler™ kits. DNA were extracted from 10 old bone samples, which kept in different environments with the postmortem interval from 10 to 20 years, in 3 hours by AutoMate Express™ system. Complete STR typing results were obtained from 8 samples. AutoMate Express™ system can quickly and efficiently extract DNA from old bones, which can be applied in forensic practice. Copyright© by the Editorial Department of Journal of Forensic Medicine

  3. Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy.

    PubMed

    Doppler, Kathrin; Appeltshauser, Luise; Krämer, Heidrun H; Ng, Judy King Man; Meinl, Edgar; Villmann, Carmen; Brophy, Peter; Dib-Hajj, Sulayman D; Waxman, Stephen G; Weishaupt, Andreas; Sommer, Claudia

    2015-01-01

    Multifocal motor neuropathy is an immune mediated disease presenting with multifocal muscle weakness and conduction block. IgM auto-antibodies against the ganglioside GM1 are detectable in about 50% of the patients. Auto-antibodies against the paranodal proteins contactin-1 and neurofascin-155 and the nodal protein neurofascin-186 have been detected in subgroups of patients with chronic inflammatory demyelinating polyneuropathy. Recently, auto-antibodies against neurofascin-186 and gliomedin were described in more than 60% of patients with multifocal motor neuropathy. In the current study, we aimed to validate this finding, using a combination of different assays for auto-antibody detection. In addition we intended to detect further auto-antibodies against paranodal proteins, specifically contactin-1 and neurofascin-155 in multifocal motor neuropathy patients' sera. We analyzed sera of 33 patients with well-characterized multifocal motor neuropathy for IgM or IgG anti-contactin-1, anti-neurofascin-155 or -186 antibodies using enzyme-linked immunosorbent assay, binding assays with transfected human embryonic kidney 293 cells and murine teased fibers. We did not detect any IgM or IgG auto-antibodies against contactin-1, neurofascin-155 or -186 in any of our multifocal motor neuropathy patients. We conclude that auto-antibodies against contactin-1, neurofascin-155 and -186 do not play a relevant role in the pathogenesis in this cohort with multifocal motor neuropathy.

  4. NMR binding and crystal structure reveal that intrinsically-unstructured regulatory domain auto-inhibits PAK4 by a mechanism different from that of PAK1.

    PubMed

    Wang, Wei; Lim, Liangzhong; Baskaran, Yohendran; Manser, Ed; Song, Jianxing

    2013-08-16

    Six human PAK members are classified into groups I (PAKs 1-3) and II (PAK4-6). Previously, only group I PAKs were thought to be auto-inhibited but very recently PAK4, the prototype of group II PAKs, has also been shown to be auto-inhibited by its N-terminal regulatory domain. However, the complete auto-inhibitory domain (AID) sequence remains undefined and the mechanism underlying its auto-inhibition is largely elusive. Here, the N-terminal regulatory domain of PAK4 sufficient for auto-inhibiting and binding Cdc42/Rac was characterized to be intrinsically unstructured, but nevertheless we identified the entire AID sequence by NMR. Strikingly, an AID peptide was derived by deleting the binding-unnecessary residues, which has a Kd of 320 nM to the PAK4 catalytic domain. Consequently, the PAK4 crystal structure complexed with the entire AID has been determined, which reveals that the complete kinase cleft is occupied by 20 AID residuescomposed of an N-terminal α-helix and a previously-identified pseudosubstrate motif, thus achieving auto-inhibition. Our study reveals that PAK4 is auto-inhibited by a novel mechanism which is completely different from that for PAK1, thus bearing critical implications for design of inhibitors specific for group II PAKs. Copyright © 2013 Elsevier Inc. All rights reserved.

  5. Development of emission factors for motorcycles and shared auto-rickshaws using real-world driving cycle for a typical Indian city.

    PubMed

    Adak, Prasenjit; Sahu, Ravi; Elumalai, Suresh Pandian

    2016-02-15

    Vehicular emission is one of the most important contributors of urban air pollution. To quantify the impact of traffic on urban air quality, it is necessary to quantify vehicular emission. In many cities of India, such as Dhanbad, shared auto-rickshaw is the pre-dominant mode of transportation. Indian Driving Cycle (IDC) and Modified Indian Driving Cycle (MIDC) are used for emission testing of motorcycles, shared auto-rickshaws and passenger cars in India for regulatory purposes. IDC used for motorcycles and shared auto-rickshaws does not recognize the difference in two vehicle classes in terms of driving pattern. In real world, shared auto-rickshaws, behave differently than motorcycles. To quantify the impact of shared auto-rickshaws on urban air quality accurately, emission factors (EFs) are required to derive from real-world driving cycles (DCs). In heterogeneous traffic, vehicles of one class affect the behavior of vehicles of other classes. To estimate the emissions from different vehicle classes accurately, EFs for motorcycles and passenger cars are also required to be revised. In this study, real-world DCs were developed for motorcycles, shared auto-rickshaws and passenger cars in Dhanbad. Developed DCs were used to calculate EFs for respective classes. Shared auto-rickshaws were found to have the highest deviation from EFs derived using IDC. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. SU-F-J-156: The Feasibility of MR-Only IMRT Planning for Prostate Anatomy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vaitheeswaran, R; Sivaramakrishnan, KR; Kumar, Prashant

    Purpose: For prostate anatomy, previous investigations have shown that simulated CT (sCT) generated from MR images can be used for accurate dose computation. In this study, we demonstrate the feasibility of MR-only IMRT planning for prostate case. Methods: Regular CT (rCT) and MR images of the same patient were acquired for prostate anatomy. Regions-of-interest (ROIs) i.e. target and risk structures are delineated on the rCT. A simulated CT (sCT) is generated from the MR image using the method described by Schadewaldt N et al. Their work establishes the clinical acceptability of dose calculation results on the sCT when compared tomore » rCT. rCT and sCT are rigidly registered to ensure proper alignment between the two images. rCT and sCT are overlaid on each other and slice-wise visual inspection confirms excellent agreement between the two images. ROIs on the rCT are copied over to sCT. Philips AutoPlanning solution is used for generating treatment plans. The same treatment technique protocol (plan parameters and clinical goals) is used to generate AutoPlan-rCT and AutoPlan-sCT respectively for rCT and and sCT. DVH comparison on ROIs and slice-wise evaluation of dose is performed between AutoPlan-rCT and AutoPlan-sCT. Delivery parameters i.e. beam and corresponding segments from the AutoPlan-sCT are copied over to rCT and dose is computed to get AutoPlan-sCT-on-rCT. Results: Plan evaluation is done based on Dose Volume Histogram (DVH) of ROIs and manual slice-wise inspection of dose distribution. Both AutoPlan-rCT and AutoPlan-sCT provide a clinically acceptable plan. Also, AutoPlan-sCT-on-rCT shows excellent agreement with AutoPlan-sCT. Conclusion: The study demonstrates that it is feasible to do IMRT planning on the simulated CT image obtained from MR image for prostate anatomy. The research is supported by Philips India Ltd.« less

  7. --No Title--

    Science.gov Websites

    : 0; } .dl-horizontal dt { float: none; width: auto; clear: none; text-align: left; } .dl-horizontal dd { margin-left: 0; } .container { width: auto; } .row-fluid { width: 100%; } .row, .thumbnails [class*="span"] { display: inline-block; width: auto; } .controls-row [class*="span"

  8. Operations Manual for the National Center for Physical Acoustics Infrasound Microphone

    DTIC Science & Technology

    2013-02-01

    thumbdrive.) There are three sections of the configuration file that can be edited: sensorConfig, adcConfig and autoControl . Modifying any other...for autoControl autoControl = { options = ( { doSchedule = 0; if nonzero, hourly scheduler is enabled

  9. Biomonitoring using invasive species in a large Lake: Dreissena distribution maps hypoxic zones

    USGS Publications Warehouse

    Karatayev, Alexander Y.; Burlakova, Lyubov E.; Mehler, Knut; Bocaniov, Serghei A.; Collingsworth, Paris D.; Warren, Glenn; Kraus, Richard T.; Hinchey, Elizabeth K.

    2017-01-01

    Due to cultural eutrophication and global climate change, an exponential increase in the number and extent of hypoxic zones in marine and freshwater ecosystems has been observed in the last few decades. Hypoxia, or low dissolved oxygen (DO) concentrations, can produce strong negative ecological impacts and, therefore, is a management concern. We measured biomass and densities of Dreissena in Lake Erie, as well as bottom DO in 2014 using 19 high frequency data loggers distributed throughout the central basin to validate a three-dimensional hydrodynamic-ecological lake model. We found that a deep, offshore hypoxic zone was formed by early August, restricting the Dreissena population to shallow areas of the central basin. Deeper than 20 m, where bottom hypoxia routinely develops, only young of the year mussels were found in small numbers, indicating restricted recruitment and survival of young Dreissena. We suggest that monitoring Dreissenadistribution can be an effective tool for mapping the extent and frequency of hypoxia in freshwater. In addition, our results suggest that an anticipated decrease in the spatial extent of hypoxia resulting from nutrient management has the potential to increase the spatial extent of profundal habitat in the central basin available for Dreissena expansion.

  10. Automatic image fusion of real-time ultrasound with computed tomography images: a prospective comparison between two auto-registration methods.

    PubMed

    Cha, Dong Ik; Lee, Min Woo; Kim, Ah Yeong; Kang, Tae Wook; Oh, Young-Taek; Jeong, Ja-Yeon; Chang, Jung-Woo; Ryu, Jiwon; Lee, Kyong Joon; Kim, Jaeil; Bang, Won-Chul; Shin, Dong Kuk; Choi, Sung Jin; Koh, Dalkwon; Seo, Bong Koo; Kim, Kyunga

    2017-11-01

    Background A major drawback of conventional manual image fusion is that the process may be complex, especially for less-experienced operators. Recently, two automatic image fusion techniques called Positioning and Sweeping auto-registration have been developed. Purpose To compare the accuracy and required time for image fusion of real-time ultrasonography (US) and computed tomography (CT) images between Positioning and Sweeping auto-registration. Material and Methods Eighteen consecutive patients referred for planning US for radiofrequency ablation or biopsy for focal hepatic lesions were enrolled. Image fusion using both auto-registration methods was performed for each patient. Registration error, time required for image fusion, and number of point locks used were compared using the Wilcoxon signed rank test. Results Image fusion was successful in all patients. Positioning auto-registration was significantly faster than Sweeping auto-registration for both initial (median, 11 s [range, 3-16 s] vs. 32 s [range, 21-38 s]; P < 0.001] and complete (median, 34.0 s [range, 26-66 s] vs. 47.5 s [range, 32-90]; P = 0.001] image fusion. Registration error of Positioning auto-registration was significantly higher for initial image fusion (median, 38.8 mm [range, 16.0-84.6 mm] vs. 18.2 mm [6.7-73.4 mm]; P = 0.029), but not for complete image fusion (median, 4.75 mm [range, 1.7-9.9 mm] vs. 5.8 mm [range, 2.0-13.0 mm]; P = 0.338]. Number of point locks required to refine the initially fused images was significantly higher with Positioning auto-registration (median, 2 [range, 2-3] vs. 1 [range, 1-2]; P = 0.012]. Conclusion Positioning auto-registration offers faster image fusion between real-time US and pre-procedural CT images than Sweeping auto-registration. The final registration error is similar between the two methods.

  11. AutoNR: an automated system that measures ECAP thresholds with the Nucleus Freedom cochlear implant via machine intelligence.

    PubMed

    Botros, Andrew; van Dijk, Bas; Killian, Matthijs

    2007-05-01

    AutoNRT is an automated system that measures electrically evoked compound action potential (ECAP) thresholds from the auditory nerve with the Nucleus Freedom cochlear implant. ECAP thresholds along the electrode array are useful in objectively fitting cochlear implant systems for individual use. This paper provides the first detailed description of the AutoNRT algorithm and its expert systems, and reports the clinical success of AutoNRT to date. AutoNRT determines thresholds by visual detection, using two decision tree expert systems that automatically recognise ECAPs. The expert systems are guided by a dataset of 5393 neural response measurements. The algorithm approaches threshold from lower stimulus levels, ensuring recipient safety during postoperative measurements. Intraoperative measurements use the same algorithm but proceed faster by beginning at stimulus levels much closer to threshold. When searching for ECAPs, AutoNRT uses a highly specific expert system (specificity of 99% during training, 96% during testing; sensitivity of 91% during training, 89% during testing). Once ECAPs are established, AutoNRT uses an unbiased expert system to determine an accurate threshold. Throughout the execution of the algorithm, recording parameters (such as implant amplifier gain) are automatically optimised when needed. In a study that included 29 intraoperative and 29 postoperative subjects (a total of 418 electrodes), AutoNRT determined a threshold in 93% of cases where a human expert also determined a threshold. When compared to the median threshold of multiple human observers on 77 randomly selected electrodes, AutoNRT performed as accurately as the 'average' clinician. AutoNRT has demonstrated a high success rate and a level of performance that is comparable with human experts. It has been used in many clinics worldwide throughout the clinical trial and commercial launch of Nucleus Custom Sound Suite, significantly streamlining the clinical procedures associated with cochlear implant use.

  12. Family factors associated with auto-aggressiveness in adolescents in Croatia.

    PubMed

    Tripković, Mara; Francisković, Tanja; Grgić, Neda; Ercegović, Nela; Graovac, Mirjana; Zecević, Iva

    2013-12-01

    The aim of this research is to look into the roles of families' social situation and cohesion in adolescent auto-aggressiveness in Croatia. The research was conducted on a sample of Zagreb high school students which encompassed 701 pupils of both genders aged 14-19. The basic demographic data were obtained using the Structured Demographic and Family Data Questionnaire. Auto-aggressiveness was tested using a section of the Report on Youth Aged 11-18 and the Scale of Auto-destructiveness--SAD, whereas the family cohesion was tested with the Family Adaptability and Cohesion Evaluation Scales FACES III. The obtained results show differences according to the gender: girls are more prone to auto-aggressiveness than boys (t = -3.385, df = 565, p = 0.001) and girls more often show symptoms of destructiveness (t = -3.809, df = 637, p < 0.001) and anxiety (t = -6.562, df = 640, p < 0.001), while boys show pronounced aggressiveness (t = 2.655, df = 653, p = 0.008). Significant family factors associated with auto-aggressiveness are parents' marital status (chi2 = 18.039, df = 4, p = 0.001), their financial situation (F(2.548) = 4.604, p = 0.010), alcoholic father (chi2 = 9.270, df = 2, p = 0.010), mentally ill mother (t = 5.264, df = 541, p < 0.001), as well as mentally ill father (t = 4.744, df = 529, p < 0.001), and corporal punishment by mother (F(2.542) = 8.132, p < 0.001) or father (F(2.530) = 5.341, p = 0.005). Adolescents from split families show more auto-aggressiveness. Family cohesion appears to be considerably associated with auto-aggressiveness and the adolescents that see their families as less cohesive have more mental problems (chi2 = 29.98, df = 2, p < 0.001). There is a connection between auto-destructive behavior in adolescents and family factors. Knowledge of family's social situation and cohesion may help understand, prevent and treat auto-aggressiveness in adolescents.

  13. [Oral diseases in auto-immune polyendocrine syndrome type 1].

    PubMed

    Proust-Lemoine, Emmanuelle; Guyot, Sylvie

    2017-09-01

    Auto-immune polyendocrine syndrome type 1 (APS1) also called Auto-immune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED) is a rare monogenic childhood-onset auto-immune disease. This autosomal recessive disorder is caused by mutations in the auto-immune regulator (AIRE) gene, and leads to autoimmunity targeting peripheral tissues. There is a wide variability in clinical phenotypes in patients with APSI, with auto-immune endocrine and non-endocrine disorders, and chronic mucocutaneous candidiasis. These patients suffer from oral diseases such as dental enamel hypoplasia and candidiasis. Both are frequently described, and in recent series, enamel hypoplasia and candidiasis are even the most frequent components of APS1 together with hypoparathyroidism. Both often occur during childhood (before 5 years old for canrdidiasis, and before 15 years old for enamel hypoplasia). Oral candidiasis is recurrent all life long, could become resistant to azole antifungal after years of treatment, and be carcinogenic, leading to severe oral squamous cell carcinoma. Oral components of APS1 should be diagnosed and rigorously treated. Dental enamel hypoplasia and/or recurrent oral candidiasis in association with auto-immune diseases in a young child should prompt APS1 diagnosis. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  14. Auto-fusion and the shaping of neurons and tubes.

    PubMed

    Soulavie, Fabien; Sundaram, Meera V

    2016-12-01

    Cells adopt specific shapes that are necessary for specific functions. For example, some neurons extend elaborate arborized dendrites that can contact multiple targets. Epithelial and endothelial cells can form tiny seamless unicellular tubes with an intracellular lumen. Recent advances showed that cells can auto-fuse to acquire those specific shapes. During auto-fusion, a cell merges two parts of its own plasma membrane. In contrast to cell-cell fusion or macropinocytic fission, which result in the merging or formation of two separate membrane bound compartments, auto-fusion preserves one compartment, but changes its shape. The discovery of auto-fusion in C. elegans was enabled by identification of specific protein fusogens, EFF-1 and AFF-1, that mediate cell-cell fusion. Phenotypic characterization of eff-1 and aff-1 mutants revealed that fusogen-mediated fusion of two parts of the same cell can be used to sculpt dendritic arbors, reconnect two parts of an axon after injury, or form a hollow unicellular tube. Similar auto-fusion events recently were detected in vertebrate cells, suggesting that auto-fusion could be a widely used mechanism for shaping neurons and tubes. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Patterns of synchrony for feed-forward and auto-regulation feed-forward neural networks.

    PubMed

    Aguiar, Manuela A D; Dias, Ana Paula S; Ferreira, Flora

    2017-01-01

    We consider feed-forward and auto-regulation feed-forward neural (weighted) coupled cell networks. In feed-forward neural networks, cells are arranged in layers such that the cells of the first layer have empty input set and cells of each other layer receive only inputs from cells of the previous layer. An auto-regulation feed-forward neural coupled cell network is a feed-forward neural network where additionally some cells of the first layer have auto-regulation, that is, they have a self-loop. Given a network structure, a robust pattern of synchrony is a space defined in terms of equalities of cell coordinates that is flow-invariant for any coupled cell system (with additive input structure) associated with the network. In this paper, we describe the robust patterns of synchrony for feed-forward and auto-regulation feed-forward neural networks. Regarding feed-forward neural networks, we show that only cells in the same layer can synchronize. On the other hand, in the presence of auto-regulation, we prove that cells in different layers can synchronize in a robust way and we give a characterization of the possible patterns of synchrony that can occur for auto-regulation feed-forward neural networks.

  16. Genotoxic damage in auto body shop workers.

    PubMed

    Siebel, Anna Maria; Basso da Silva, Luciano

    2010-10-01

    Some studies have shown increased DNA damage among car painters, but other professionals working in auto body and paint shops have not been extensively assessed. The aim of this study was to assess DNA damage in different types of auto body shop workers by measuring micronucleus (MN) levels in exfoliated buccal cells. The mean number of cells with MN per 2000 exfoliated buccal cells was analyzed in three groups of male workers: auto body repair technicians, painters, and office workers (control group). All participants answered a questionnaire inquiring about age, smoking habits, alcohol consumption, work practices, occupational exposure time, job activities, and use of protective equipment. The mean number of cells with MN was 3.50 ± 1.50 in auto body painters, 3.91 ± 2.10 in auto body repair technicians, and 0.80 ± 0.78 in office workers, with a significant difference between the control group and the two other groups (p = 0.0001). Age, occupational exposure time, use of protective masks, alcohol consumption, and smoking habit did not affect MN results. The findings indicate that technicians and painters working in auto body shops are at risk for genotoxic damage, while office workers seem to be protected.

  17. Fisher and marten

    Treesearch

    Roger A. Powell; Steven W. Buskirk; William J. Zielinski

    2003-01-01

    The genus Martes is circumboreal in distribution, with extensions into southern (M. gwatkinsii) and southeast Asia as far as 7°S latitude (M. flavigula; Anderson 1970). The fisher (subgenus Pekania) is endemic to the New World and restricted to mesic coniferous forest of the boreal zone and its...

  18. 33 CFR 334.620 - Straits of Florida and Florida Bay in vicinity of Key West, Fla.; operational training area...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA... the exclusion of watercraft is required in the interest of safety or for accomplishment of the mission...

  19. 33 CFR 334.620 - Straits of Florida and Florida Bay in vicinity of Key West, Fla.; operational training area...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA... the exclusion of watercraft is required in the interest of safety or for accomplishment of the mission...

  20. 33 CFR 334.620 - Straits of Florida and Florida Bay in vicinity of Key West, Fla.; operational training area...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA... the exclusion of watercraft is required in the interest of safety or for accomplishment of the mission...

  1. 33 CFR 334.620 - Straits of Florida and Florida Bay in vicinity of Key West, Fla.; operational training area...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA... the exclusion of watercraft is required in the interest of safety or for accomplishment of the mission...

  2. 33 CFR 334.620 - Straits of Florida and Florida Bay in vicinity of Key West, Fla.; operational training area...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA... the exclusion of watercraft is required in the interest of safety or for accomplishment of the mission...

  3. Evaluation of Superpave Gyratory Compaction of Hot Mix Asphalt

    DOT National Transportation Integrated Search

    1988-01-01

    About 85 percent of hot mix asphalt (HMA) by volume consist of mineral aggregate. One of the most important properties of the aggregate in a HMA mix is the gradation. This study was carried out to evaluate the effect of restricted zone on volumetric ...

  4. 33 CFR 334.230 - Potomac River.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 334.230 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.230 Potomac River. (a) Naval Surface Warfare... manned or unmanned watercraft. (ii) When hazardous operations are in progress, no person, or fishing or...

  5. 33 CFR 334.230 - Potomac River.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 334.230 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.230 Potomac River. (a) Naval Surface Warfare... manned or unmanned watercraft. (ii) When hazardous operations are in progress, no person, or fishing or...

  6. 33 CFR 334.230 - Potomac River.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 334.230 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.230 Potomac River. (a) Naval Surface Warfare... manned or unmanned watercraft. (ii) When hazardous operations are in progress, no person, or fishing or...

  7. 33 CFR 334.230 - Potomac River.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 334.230 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.230 Potomac River. (a) Naval Surface Warfare... manned or unmanned watercraft. (ii) When hazardous operations are in progress, no person, or fishing or...

  8. A DS-UWB Cognitive Radio System Based on Bridge Function Smart Codes

    NASA Astrophysics Data System (ADS)

    Xu, Yafei; Hong, Sheng; Zhao, Guodong; Zhang, Fengyuan; di, Jinshan; Zhang, Qishan

    This paper proposes a direct-sequence UWB Gaussian pulse of cognitive radio systems based on bridge function smart sequence matrix and the Gaussian pulse. As the system uses the spreading sequence code, that is the bridge function smart code sequence, the zero correlation zones (ZCZs) which the bridge function sequences' auto-correlation functions had, could reduce multipath fading of the pulse interference. The Modulated channel signal was sent into the IEEE 802.15.3a UWB channel. We analysis the ZCZs's inhibition to the interference multipath interference (MPI), as one of the main system sources interferences. The simulation in SIMULINK/MATLAB is described in detail. The result shows the system has better performance by comparison with that employing Walsh sequence square matrix, and it was verified by the formula in principle.

  9. Cellular polarity and interactions in plant graviperception

    NASA Technical Reports Server (NTRS)

    Sack, Fred D.

    1993-01-01

    Presented are results of studies on the mechanisms of gravitropic sensing in higher and lower plants. Gravitropic roots of the aquatic angiosperm, Limnobium, were found to have sedimented amyloplasts in their elongation zone but not in their rootcap; nuclei were found to sediment in the elongation zone as well. Another study attempted to understand how plastid sedimentation occurs in vertical Ceratodon cells and how this sedimentation is regulated. To determine whether the cytoskeleton restricts plastid sedimentation, the effects of amiprophos-methyl (APM) and cytochalasin (CD) on plastid position were qualified. Results suggest that microtubules restrict the sedimentation of plastids along the length of the cell and that microtubules are load-bearing for all the plastids in the apical cell, demonstrating the importance of the cytoskeleton in maintaining organelle position and cell organization against the force of gravity. Physcomitrella and Funaria were also studied. Results suggest that gravitropism may be relatively common in moss protonemata and reinforce the idea that amyloplast mass functions in gravitropic sensing.

  10. Development of extraterrestrial intelligence and physical laws

    NASA Astrophysics Data System (ADS)

    Troitskij, V. S.

    This paper considers the restrictions imposed by physical laws on the development of life and intelligence in the form of extraterrestrial civilizations. For this purpose intelligence is defined as the community of intelligent beings, joined by the exchange of mass, energy and information both between themselves and with the external medium. Due to the limitation of the velocity of exchange of information and, in particular, mass and energy exchange, the dimensions of the intelligence cannot exceed some light days, i.e. they are limited by the habitable zone about their star. It is shown that the energy consumption should not exceed the energy output of their star for the sake of preserving the cosmic near-star zone of life from energetic pollution. With the above restrictions of the energy product it takes millions of years to create an omnidirectional beacon-transmitter signals from which would be received by the contemporary antennas in all our Galaxy. It is realistic to create an omnidirectional beacon operating in the range of no more than 100-1000 light years.

  11. Applications of ISES for coastal zone studies

    NASA Technical Reports Server (NTRS)

    Bartlett, D. S.

    1990-01-01

    In contrast to the discipline- and process-oriented topics addressed, coastal zone studies are defined geographically by the special circumstances inherent in the interface between land and water. The characteristics of coastal zones which make them worthy of separate consideration are: (1) the dynamic nature of natural and anthropogenic processes taking place; (2) the relatively restricted spatial domain of the narrow land/water interface; and (3) the large proportion of the Earth's population living within coastal zones, and the resulting extreme pressure on natural and human resources. These characteristics place special constraints and priorities on remote sensing applications, even though the applications themselves bear close relation to those addressed by other elements of this report (e.g., oceans, ice, vegetation/land use). The discussion which follows first describes the suite of remote sensing activities relevant to coastal zone studies. Potential Information Sciences Experiment System (ISES) experiments will then be addressed within two general categories: applications of real-time data transmission and applications of onboard data acquisition and processing.

  12. Venus - Limited extension and volcanism along zones of lithospheric weakness

    NASA Technical Reports Server (NTRS)

    Schaber, G. G.

    1982-01-01

    Three global-scale zones of possible tectonic origin are described as occurring along broad, low rises within the Equatorial Highlands on Venus (lat 50 deg N to 50 deg S, long 60 deg to 310 deg). The two longest of these tectonic zones, the Aphrodite-Beta and Themis-Atla zones, extend for 21,000 and 14,000 km, respectively. Several lines of evidence indicate that Beta and Atla Regiones, located at the only two intersections of the three major tectonic zones, are dynamically supported volcanic terranes associated with currently active volcanism. Rift valleys south of Aphrodite Terra and between Beta and Phoebe Regiones are characterized by 75- to 100-km widths, raised rims, and extensions of only a few tens of kilometers, about the same magnitudes as in continental rifts on the earth. Horizontal extension on Venus was probably restricted by an early choking-off of plate motion by high crustal and upper-mantle temperatures, and the subsequent loss of water and an asthenosphere.

  13. Telemetry Standards, IRIG Standard 106-17, Chapter 22, Network Based Protocol Suite

    DTIC Science & Technology

    2017-07-01

    ER Fiber media connections using 10 Gigabit Ethernet shall comply with IEEE 802.3-2012, Section 5, Clause 52. 22.2.1.1.4 Auto- Negotiation ...22.2.1.1.4.1 Copper Auto- Negotiation Copper media connections, as described in the preceding sections, shall support auto- negotiation of speed, duplex, and...flow control in the manner specified in IEEE 802.3-2012, Section 2, Clause 28. 22.2.1.1.4.2 Fiber Auto- Negotiation Gigabit and 10 Gigabit fiber

  14. A Code Generation Approach for Auto-Vectorization in the Spade Compiler

    NASA Astrophysics Data System (ADS)

    Wang, Huayong; Andrade, Henrique; Gedik, Buğra; Wu, Kun-Lung

    We describe an auto-vectorization approach for the Spade stream processing programming language, comprising two ideas. First, we provide support for vectors as a primitive data type. Second, we provide a C++ library with architecture-specific implementations of a large number of pre-vectorized operations as the means to support language extensions. We evaluate our approach with several stream processing operators, contrasting Spade's auto-vectorization with the native auto-vectorization provided by the GNU gcc and Intel icc compilers.

  15. Density Zoning and Class Segregation in U.S. Metropolitan Areas

    PubMed Central

    Rothwell, Jonathan T.; Massey, Douglas S.

    2013-01-01

    Objectives Socioeconomic segregation rose substantially in U.S. cities during the final decades of the 20th century and we argue zoning regulations are an important cause for this increase. Methods We measure neighborhood economic segregation using the Gini Coefficient for neighborhood income inequality and the poor-affluent exposure index. These outcomes are regressed on an index of density zoning developed from the work of Pendall for 50 U.S. metropolitan areas, while controlling for other metropolitan characteristics likely to affect urban housing markets and class segregation. Results For both 2000 and changes from 1990 to 2000, OLS estimates reveal a strong relationship between density zoning and income segregation, and replication using 2SLS suggests that the relationship is causal. We also show that zoning is associated with higher inter-jurisdictional inequality. Conclusions Metropolitan areas with suburbs that restrict the density of residential construction are more segregated on the basis of income than those with more permissive density zoning regimes. This arrangement perpetuates and exacerbates racial and class inequality in the United States. PMID:21117332

  16. Fiscal Year 2008 Phased Construction Completion Report for EU Z2-33 in Zone 2, East Tennessee Technology Park, Oak Ridge, Tennessee

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bechtel Jacobs

    The Record of Decision for Soil, Buried Waste, and Subsurface Structure Actions in Zone 2, East Tennessee Technology Park, Oak Ridge, Tennessee (DOE/OR/01-2161&D2) (Zone 2 ROD) acknowledged that most of the 800 acres in Zone 2 were contaminated, but that sufficient data to confirm the levels of contamination were lacking. The Zone 2 ROD further specified that a sampling strategy for filling the data gaps would be developed. The Remedial Design Report/Remedial Action Work Plan for Zone 2 Soils, Slabs, and Subsurface Structures, East Tennessee Technology Park, Oak Ridge, Tennessee (DOE/OR/01-2224&D3) (Zone 2 RDR/RAWP) defined the sampling strategy as themore » Dynamic Verification Strategy (DVS), generally following the approach used for characterization of the Zone 1 exposure units (EUs). The Zone 2 ROD divided the Zone 2 area into seven geographic areas and 44 EUs. To facilitate the data quality objectives (DQOs) of the DVS process, the Zone 2 RDR/RAWP regrouped the 44 EUs into 12 DQO scoping EU groups. These groups facilitated the DQO process by placing similar facilities and their support facilities together and allowing identification of data gaps. The EU groups were no longer pertinent after DQO planning was completed and characterization was conducted as areas became accessible. As the opportunity to complete characterization became available, the planned DVS program and remedial actions (RAs) were completed for EU Z2-33. Remedial action was also performed at two additional areas in adjacent EU Z2-42 because of their close proximity and similar nature to a small surface soil RA in EU Z2-33. Remedial actions for building slabs performed in EU Z2-33 during fiscal year (FY) 2007 were reported in the Fiscal Year 2007 Phased Construction Completion Report for the Zone 2 Soils, Slabs, and Subsurface Structures at East Tennessee Technology Park, Oak Ridge, Tennessee (DOE/OR/01-2723&D1). Recommended RAs for EU Z2-42 were described in the Fiscal Year 2006 Phased Construction Completion Report for the Zone 2 Soils, Slabs, and Subsurface Structures at East Tennessee Technology Park, Oak Ridge, Tennessee (DOE/OR/01-2317&D2). Remedial actions performed in the Balance of Site (BOS) Laboratory Area of EU Z2-33 and two small areas in EU Z2-42 are described in Sects. 5 through 10 of this Phased Construction Completion Report (PCCR). The purpose of this PCCR is to address the following: (1) Document DVS characterization results for EU Z2-33; (2) Describe and document the risk evaluation and determine if the EU meets the Zone 2 ROD requirements for unrestricted industrial use to 10 ft bgs; (3) Identify additional areas not defined in the Zone 2 ROD that require remediation based on the DVS evaluation results; and (4) Describe RAs performed in the EU Z2-33 BOS Laboratory Area and two small areas in EU Z2-42. Approximately 18 acres in EU Z2-33 are addressed in this PCCR. Based on the results of the DVS evaluation and RAs performed, all 18 acres are recommended for unrestricted industrial use to 10 ft bgs. Three Federal Facility Agreement sites are addressed and recommended for no further action within this acreage, including: (1) K-1004-L Recirculating Cooling Water Lines Leak Sites; (2) K-1044 Heavy Equipment Repair Shop; and (3) K-1015-A Laundry Pit. Remedial actions for EU Z2-33 were developed in response to DVS characterization results described in the EU Z2-33 Technical Memorandum (Appendix A) and to support reindustrialization of the East Tennessee Technology Park as a commercial industrial park. Remediation criteria were designed for the protection of a future industrial worker who normally would not have the potential for exposure to soil below 10ft bgs. Accordingly, the Zone 2 ROD required land use controls to prevent disturbance of soils below 10 ft deep and to restrict future land use to industrial/commercial activities. In response to stakeholder comments, the U.S. Department of Energy agreed to re-evaluate the need for such land use restrictions. This document includes a screening evaluation to determine the likelihood of land use controls in EU Z2-33 being modified to: (1) eliminate the restriction on disturbance of soils below 10 ft bgs where data indicate the absence of residual contamination at any depth that would result in an unacceptable risk to the future industrial worker, and (2) permit alternative land uses that would be protective of future site occupants. Results of this screening evaluation indicate a low probability that restrictions on disturbing soil below 10 ft bgs could be safely eliminated for EU Z2-33. A qualitative screening evaluation considered the likelihood of unrestricted land use being protective of future site occupants. Based on this qualitative assessment, all 18 acres addressed in this PCCR were assigned a low probability for consideration of release for unrestricted land use.« less

  17. Early relapse after single auto-SCT for multiple myeloma is a major predictor of survival in the era of novel agents.

    PubMed

    Jimenez-Zepeda, V H; Reece, D E; Trudel, S; Chen, C; Tiedemann, R; Kukreti, V

    2015-02-01

    The role of auto-SCT in the treatment of multiple myeloma (MM) in the era of novel agents continues to evolve. It is now clear that the depth of response and clinical outcomes have significantly improved as a result of the combination of these strategies. However, not all patients with MM who undergo auto-SCT are able to sustain a meaningful response and 20% of patients relapse shortly after auto-SCT. In this study, we aimed to assess the impact of early relapse (ER) after auto-SCT on OS for MM patients undergoing single auto-SCT who had received novel agent-based induction regimens. All consecutive patients with MM undergoing single auto-SCT from January 2002 to September 2012 who had novel induction therapy were evaluated. A total of 184 patients were identified. The median OS and PFS for the group of transplanted patients were 93 and 25.4 months, respectively. Median time to relapse was 17.2 months with 40% having relapsed at the time of analysis. ER (<12 months post auto-SCT) was seen in 27 (36%) out of 75 patients who had relapsed, and median OS was significantly shorter than in those with non-ER. Multivariate analysis showed ER as the major independent prognostic factor for OS. On the basis of these findings, we conclude that not only attainment of a good response, but sustainability of it, appears to be a major prognostic variable in MM in the era of novel therapy. Patients with ER post auto-SCT should biologically be characterized in prospective studies to better understand the mechanisms of resistance associated with this particular entity.

  18. Efficacy of Bilevel-auto Treatment in Patients with Obstructive Sleep Apnea Not Responsive to or Intolerant of Continuous Positive Airway Pressure Ventilation

    PubMed Central

    Carlucci, Annalisa; Ceriana, Piero; Mancini, Marco; Cirio, Serena; Pierucci, Paola; D'Artavilla Lupo, Nadia; Gadaleta, Felice; Morrone, Elisa; Fanfulla, Francesco

    2015-01-01

    Background: Ventilation with continuous positive airway pressure (CPAP) is the gold standard therapy for obstructive sleep apnea (OSA). However, it was recently suggested that a novel mode of ventilation, Bilevel-auto, could be equally effective in treating patients unable to tolerate CPAP. The aim of this study was to investigate the ability of Bilevel-auto to treat OSA patients whose nocturnal ventilatory disturbances are not completely corrected by CPAP. Methods: We enrolled 66 consecutive OSA patients, not responsive to (group A) or intolerant of (group B) CPAP treatment, after a full night of manual CPAP titration in a laboratory. Full polysomnography data and daytime sleepiness score were compared for each group in the three different conditions: basal, during CPAP, and during Bilevel-auto. Results: The apnea-hypopnea index decreased significantly during CPAP in both groups; however, in the group A, there was a further significant improvement during Bilevel-auto. The same trend was observed for oxygenation indices, while the distribution and the efficiency of sleep did not differ following the switch from CPAP to Bilevel-auto. Conclusions: This study confirmed the role of Bilevel-auto as an effective therapeutic alternative to CPAP in patients intolerant of this latter mode of ventilation. Moreover, extending the use of Bilevel-auto to those OSA patients not responsive to CPAP, we showed a significantly better correction of nocturnal respiratory disturbances. Citation: Carlucci A, Ceriana P, Mancini M, Cirio S, Pierucci P, D'Artavilla Lupo N, Gadaleta F, Morrone E, Fanfulla F. Efficacy of Bilevel-auto treatment in patients with obstructive sleep apnea not responsive to or intolerant of continuous positive airway pressure ventilation. J Clin Sleep Med 2015;11(9):981–985. PMID:25902825

  19. Impact of Routine Surveillance Imaging on Outcomes of Patients With Diffuse Large B-Cell Lymphoma After Autologous Hematopoietic Cell Transplantation.

    PubMed

    Epperla, Narendranath; Shah, Namrata; Hamadani, Mehdi; Richardson, Kristin; Kapke, Jonathan T; Patel, Asmita; Teegavarapu, Sravanthi P; Carrum, George; Hari, Parameswaran N; Pingali, Sai R; Karmali, Reem; Fenske, Timothy S

    2016-12-01

    For patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), autologous hematopoietic cell transplantation (auto-HCT) is commonly used. After auto-HCT, DLBCL patients are often monitored with surveillance imaging. However, there is little evidence to support this practice. We performed a multicenter retrospective study of DLBCL patients who underwent auto-HCT (n = 160), who experienced complete remission after transplantation, and who then underwent surveillance imaging. Of these, only 45 patients experienced relapse after day +100 after auto-HCT, with relapse detected by routine imaging in 32 (71%) and relapse detected clinically in 13 (29%). Baseline patient characteristics were similar between the 2 groups. Comparing the radiographic and clinically detected relapse groups, the median time from diagnosis to auto-HCT (389 days vs. 621 days, P = .06) and the median follow-up after auto-HCT (2464 days vs. 1593 days P = .60) were similar. The median time to relapse after auto-HCT was 191 days in radiographically detected relapses compared to 492 days in clinically detected relapses (P = .35), and median postrelapse survival was 359 days in such patients compared to 123 days in patients with clinically detected relapse (P = .36). However, the median posttransplantation overall survival was not significantly different for patients with relapse detected by routine imaging versus relapse detected clinically (643 vs. 586 days, P = .68). A majority (71%) of DLBCL relapses after auto-HCT are detected by routine surveillance imaging. Overall, there appears to be limited utility for routine imaging after auto-HCT except in select cases where earlier detection and salvage therapy with allogeneic HCT is a potential option. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Recent advances in post autologous transplantation maintenance therapies in B-cell non-Hodgkin lymphomas

    PubMed Central

    Epperla, Narendranath; Fenske, Timothy S; Hari, Parameswaran N; Hamadani, Mehdi

    2015-01-01

    Lymphomas constitute the second most common indication for high dose therapy (HDT) followed by autologous hematopoietic cell transplantation (auto-HCT). The intent of administering HDT in these heterogeneous disorders varies from cure (e.g., in relapsed aggressive lymphomas) to disease control (e.g., most indolent lymphomas). Regardless of the underlying histology or remission status at transplantation, disease relapse remains the number one cause of post auto-HCT therapy failure and mortality. The last decade has seen a proliferation of clinical studies looking at prevention of post auto-HCT therapy failure with various maintenance strategies. The benefit of such therapies is in turn dependent on disease histology and timing of transplantation. In relapsed, chemosensitive diffuse large B-cell lymphoma (DLBCL), although post auto-HCT maintenance rituximab seems to be safe and feasible, it does not provide improved survival outcomes and is not recommended. The preliminary results with anti- programmed death -1 (PD-1) antibody therapy as post auto-HCT maintenance in DLBCL is promising but requires randomized validation. Similarly in follicular lymphoma, maintenance therapies including rituximab following auto-HCT should be considered investigational and offered only on a clinical trial. Rituximab maintenance results in improved progression-free survival but has not yet shown to improve overall survival in mantle cell lymphoma (MCL), but given the poor prognosis with post auto-HCT failure in MCL, maintenance rituximab can be considered on a case-by-case basis. Ongoing trials evaluating the efficacy of post auto-HCT maintenance with novel compounds (e.g., immunomodulators, PD-1 inhibitors, proteasome inhibitors and bruton’s tyrosine kinase inhibitors) will likely change the practice landscape in the near future for B cell non-Hodgkin lymphomas patients following HDT and auto-HCT. PMID:26421260

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