Science.gov

Sample records for automated production line

  1. Automated solar panel assembly line

    NASA Technical Reports Server (NTRS)

    Somberg, H.

    1981-01-01

    The initial stage of the automated solar panel assembly line program was devoted to concept development and proof of approach through simple experimental verification. In this phase, laboratory bench models were built to demonstrate and verify concepts. Following this phase was machine design and integration of the various machine elements. The third phase was machine assembly and debugging. In this phase, the various elements were operated as a unit and modifications were made as required. The final stage of development was the demonstration of the equipment in a pilot production operation.

  2. Generators and automated generator systems for production and on-line injections of pet radiopharmaceuticals

    NASA Astrophysics Data System (ADS)

    Shimchuk, G.; Shimchuk, Gr; Pakhomov, G.; Avalishvili, G.; Zavrazhnov, G.; Polonsky-Byslaev, I.; Fedotov, A.; Polozov, P.

    2017-01-01

    One of the prospective directions of PET development is using generator positron radiating nuclides [1,2]. Introduction of this technology is financially promising, since it does not require expensive special accelerator and radiochemical laboratory in the medical institution, which considerably reduces costs of PET diagnostics and makes it available to more patients. POZITOM-PRO RPC LLC developed and produced an 82Sr-82Rb generator, an automated injection system, designed for automatic and fully-controlled injections of 82RbCl produced by this generator, automated radiopharmaceutical synthesis units based on generated 68Ga produced using a domestically-manufactured 68Ge-68Ga generator for preparing two pharmaceuticals: Ga-68-DOTA-TATE and Vascular Ga-68.

  3. ALFA: Automated Line Fitting Algorithm

    NASA Astrophysics Data System (ADS)

    Wesson, R.

    2015-12-01

    ALFA fits emission line spectra of arbitrary wavelength coverage and resolution, fully automatically. It uses a catalog of lines which may be present to construct synthetic spectra, the parameters of which are then optimized by means of a genetic algorithm. Uncertainties are estimated using the noise structure of the residuals. An emission line spectrum containing several hundred lines can be fitted in a few seconds using a single processor of a typical contemporary desktop or laptop PC. Data cubes in FITS format can be analysed using multiple processors, and an analysis of tens of thousands of deep spectra obtained with instruments such as MUSE will take a few hours.

  4. Office Automation Boosts University's Productivity.

    ERIC Educational Resources Information Center

    School Business Affairs, 1986

    1986-01-01

    The University of Pittsburgh has a 2-year agreement designating the Xerox Corporation as the primary supplier of word processing and related office automation equipment in order to increase productivity and more efficient use of campus resources. (MLF)

  5. A novel fully automated on-line coupled liquid chromatography-gas chromatography technique used for the determination of organochlorine pesticide residues in tobacco and tobacco products.

    PubMed

    Qi, Dawei; Fei, Ting; Sha, Yunfei; Wang, Leijun; Li, Gang; Wu, Da; Liu, Baizhan

    2014-12-29

    In this study, a novel fully automated on-line coupled liquid chromatography-gas chromatography (LC-GC) technique was reported and applied for the determination of organochlorine pesticide residues (OCPs) in tobacco and tobacco products. Using a switching valve to isolate the capillary pre-column and the analytical column during the solvent evaporation period, the LC solvent can be completely removed and prevented from reaching the GC column and the detector. The established method was used to determinate the OCPs in tobacco samples. By using Florisil SPE column and employing GPC technique, polarity impurities and large molecule impurities were removed. A dynamic range 1-100ng/mL was achieved with detection limits from 1.5 to 3.3μg/kg. The method exhibited good repeatability and recoveries. This technology may provide an alternative way for trace analysis of complex samples.

  6. ALFA: an automated line fitting algorithm

    NASA Astrophysics Data System (ADS)

    Wesson, R.

    2016-03-01

    I present the automated line fitting algorithm, ALFA, a new code which can fit emission line spectra of arbitrary wavelength coverage and resolution, fully automatically. In contrast to traditional emission line fitting methods which require the identification of spectral features suspected to be emission lines, ALFA instead uses a list of lines which are expected to be present to construct a synthetic spectrum. The parameters used to construct the synthetic spectrum are optimized by means of a genetic algorithm. Uncertainties are estimated using the noise structure of the residuals. An emission line spectrum containing several hundred lines can be fitted in a few seconds using a single processor of a typical contemporary desktop or laptop PC. I show that the results are in excellent agreement with those measured manually for a number of spectra. Where discrepancies exist, the manually measured fluxes are found to be less accurate than those returned by ALFA. Together with the code NEAT, ALFA provides a powerful way to rapidly extract physical information from observations, an increasingly vital function in the era of highly multiplexed spectroscopy. The two codes can deliver a reliable and comprehensive analysis of very large data sets in a few hours with little or no user interaction.

  7. Productivity goals drive office automation

    NASA Technical Reports Server (NTRS)

    Bradley, A. P.; Kurzhals, P. R.

    1983-01-01

    Office automation (OA) steps being taken by NASA to improve efficiency in communications between centers and personnel are outlined. NASA centers are currently linked by satellite for electronic mail and scheduling through dumb and intelligent terminals. The implementation of teleconferencing with interactive graphics transmitted between dial-up terminals is being examined in a pilot program, and interactive data bases are already in operation, with an on-line summary data base being planned for NASA headquarters. The NASA Recon on-line service is operating with citations of over 2,200,000 aeronautics and astronautics research documents and 300,000 scientific books accessed by over 250 terminals around the U.S. The emphasis for all the OA systems is on user-friendly design and minimizing the required input for entry and access.

  8. Product Line Systems Program

    DTIC Science & Technology

    2008-03-01

    Mellon University Product Line Systems Program Our mission: • create, mature, apply, and transition technology and practices • to effect... Technology Initiative) Predictable Software Construction (Predictable Assembly from Certifiable Code Initiative) Software Product Lines (Product...Presentation Software Architecture (Software Architecture Technology Initiative) Predictable Software Construction (Predictable Assembly from Certifiable

  9. Software Product Lines Essentials

    DTIC Science & Technology

    2008-07-01

    improvement Technology innovation Reuse 7 Software Product Lines Linda Northrop © 2008 Carnegie Mellon University Few Systems Are Unique Most...Focus was small-grained, opportunistic, and technology -driven. Results did not meet business goals. Reuse History 9 Software Product Lines Linda...servers, storage servers, network camera and scanner servers Bold Stroke Avionics Customized solutions for transportation industries E-COM Technology

  10. Production planning and automated imposition

    NASA Astrophysics Data System (ADS)

    Tuijn, Chris

    2007-01-01

    The production planning in a printing organization is quite complex since there are many parameters to consider such as the work to be done, the available devices and the available resources. Printed products such as books, magazines, leaflets etc. all consist of sections that will be printed on a press sheet. After printing, the sheets will be folded and cut. As a last step, the different sections belonging to the same product will be collected and bound together (glued, stapled, stitched etc.). In the prepress environment, one traditionally uses special imposition templates to identify how the pages should be imposed on the press sheet. The main drawback of this approach is that one needs to remake imposition templates each time a parameter has been changed. A new approach to overcome this problem has been proposed by the CIP4 graphic standards organization and consists of specifying a so-called stripping specification of the sections on the sheet. In addition to the stripping information, one also can specify how the sections can be combined physically. This is done in the so-called assembly specification. Both stripping and assembly allow defining unambiguously how a product can be produced. In the first part of the paper, we will explain in detail how the stripping and assembly specification can be used to further automate the prepress, printing and finishing processes. In the second part, we will discuss how the production planning itself can be automated. This assumes an in-depth knowledge of the device characteristics (press and finishing equipment) and the available resources (plates, paper, ink).

  11. Nuclear Energy Research Initiative Annual Report-Innovative Approaches to Automating QA/QC of Fuel Particle Production Using On-Line Nondestructive Methods for Higher Reliability.

    SciTech Connect

    Hockey, Ronald L.; Bond, Leonard J.; Ahmed, Salahuddin; Sandness, Gerald A.; Gray, Joseph N.; Batishko, Charles R.; Flake, Matthew; Panetta, Paul D.; Saurwein, John J.; Lowden, Richard A.; Good, Morris S.

    2004-04-20

    This document summarizes the activities performed and progress made in FY-03. Various approaches for automating the particle fuel production QC process using on-line nondestructive methods for higher reliability were evaluated. In this first-year of a three-year project, surrogate fuel particles made available for testing included leftovers from initial coater development runs. These particles had a high defect fraction and the particle properties spanned a wide range, providing the opportunity to examine worst-case conditions before refining the inspection methods to detect more subtle coating features. Particles specifically designed to evaluate the NDE methods being investigated under this project will be specified and fabricated at ORNL early next reporting period. The literature was reviewed for existing inspection technology and to identify many of the fuel particle conditions thought to degrade its performance. A modeling study, including the electromagnetic and techniques, showed that the in-line electromagnetic methods should provide measurable responses to missing layers, kernel diameter, and changes in coating layer thickness, with reasonable assumptions made for material conductivities. The modeling study for the ultrasonic methods provided the resonant frequencies that should be measured using the resonant ultrasound technique, and the results from these calculations were published in the proceedings for two conferences. The notion of a particle quality index to relate coating properties to fabrication process parameters was explored. Progress was made in understanding the fabrication process. GA identified key literature in this area and Saurwein (2003a) provided a literature review/summary. This literature has been reviewed. An approach previously applied to flexible manufacturing was adopted and the modification and development of the concepts to meet TRISO particle fuel manufacturing and QA/QC needs initiated. This approach establishes

  12. Development of Automated Production Line Processes for Solar Brightfield Modules: Final Annual Technical Progress Report, 1 July 2004 -- 15 October 2005

    SciTech Connect

    Nowlan, M. J.; Murach, J. M.; Sutherland, S. F.; Miller, D. C.; Moore S. B.; Hogan, S. J.

    2006-08-01

    Spire Corporation is addressing the Photovoltaic Manufacturing R&D project goals of improving photovoltaic (PV) manufacturing processes and products while reducing costs and providing a technology foundation that supports significant manufacturing scale-up. To accomplish this, we are focusing our efforts on the design of a large-area utility-scale module and the development of the necessary manufacturing techniques and equipment to manufacture such a module in a high-volume production environment. A three-phase program is under way for developing and demonstrating new automated systems for fabricating very large PV modules ideal for use in multi-megawatt grid-connected applications. We designed a large-area (1.57 m x 3.68 m) 800-W module, and we are developing associated module production equipment that will minimize the total installed system cost for utility-scale PV arrays. Activities in Phase 2 focused on the development of automation for module materials lay-up, cell string busing, and module lamination; enhancements to the cell stringing and lamination processes; and performance testing of large-area modules.

  13. Automated Product Test Wafer Procedure

    NASA Astrophysics Data System (ADS)

    Brown, Andrew; Minvielle, Anna; Salugsugan, Anita

    1987-04-01

    An automated test wafer procedure has been developed using the KLA 2020 wafer inspector to measure registration and critical dimensions on production wafers. The procedure reduces operator interactions to loading the wafer and entering information for wafer identification. The analysis of the registration data is performed on a PC using the methods established by Perloff to determine both intrafield and grid errors. These results are then used to correct the stepper. CD data is also analyzed by the program and corrections to the exposure time are calculated. It was found that the KLA 2020 is as much as 10 times faster and 4 times more precise in obtaining registration data then an operator reading optical verniers on a microscope. Due to the high precision of the reading, the analysis does not need a large number of readings to obtain precise and accurate stepper corrections. Further, significant improvements can be obtained by adding registration targets to measure the intrafield errors. Using the KLA 2020 and computer analysis we have demonstrated an ability to reduce the errors for a manually aligned run to a one sigma distribution of 0.09 um for x and y translation, 0.4 PPM for scaling and orthogonality, and 2.3 PPM for rotation from the first test wafer for a GCA 6100. Nearly all of this variation is due to operator misalignment or the inability of the stepper to correct the errors. The corrections with this technique measuring the same wafer are precise to + 0.01 um in translation and + 0.5 PPM for rotation, scaling, and orthogonality. It has also been shown that a simple linear equation can be used to correct exposure time, even when a process is not tightly controlled.

  14. Nuclear Energy Research Initiative Project No. 02 103 Innovative Low Cost Approaches to Automating QA/QC of Fuel Particle Production Using On Line Nondestructive Methods for Higher Reliability Final Project Report

    SciTech Connect

    Ahmed, Salahuddin; Batishko, Charles R.; Flake, Matthew; Good, Morris S.; Mathews, Royce; Morra, Marino; Panetta, Paul D.; Pardini, Allan F.; Sandness, Gerald A.; Tucker, Brian J.; Weier, Dennis R.; Hockey, Ronald L.; Gray, Joseph N.; Saurwein, John J.; Bond, Leonard J.; Lowden, Richard A.; Miller, James H.

    2006-02-28

    This Nuclear Energy Research Initiative (NERI) project was tasked with exploring, adapting, developing and demonstrating innovative nondestructive test methods to automate nuclear coated particle fuel inspection so as to provide the United States (US) with necessary improved and economical Quality Assurance and Control (QA/QC) that is needed for the fuels for several reactor concepts being proposed for both near term deployment [DOE NE & NERAC, 2001] and Generation IV nuclear systems. Replacing present day QA/QC methods, done manually and in many cases destructively, with higher speed automated nondestructive methods will make fuel production for advanced reactors economically feasible. For successful deployment of next generation reactors that employ particle fuels, or fuels in the form of pebbles based on particles, extremely large numbers of fuel particles will require inspection at throughput rates that do not significantly impact the proposed manufacturing processes. The focus of the project is nondestructive examination (NDE) technologies that can be automated for production speeds and make either: (I) On Process Measurements or (II) In Line Measurements. The inspection technologies selected will enable particle “quality” qualification as a particle or group of particles passes a sensor. A multiple attribute dependent signature will be measured and used for qualification or process control decisions. A primary task for achieving this objective is to establish standard signatures for both good/acceptable particles and the most problematic types of defects using several nondestructive methods.

  15. Multiresidue trace analysis of pharmaceuticals, their human metabolites and transformation products by fully automated on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry.

    PubMed

    García-Galán, María Jesús; Petrovic, Mira; Rodríguez-Mozaz, Sara; Barceló, Damià

    2016-09-01

    A novel, fully automated analytical methodology based on dual column liquid chromatography coupled to tandem mass spectrometry (LC-LC-MS(2)) has been developed and validated for the analysis of 12 pharmaceuticals and 20 metabolites and transformation products in different types of water (influent and effluent wastewaters and surface water). Two LC columns were used - one for pre-concentration of the sample and the second for separation and analysis - so that water samples were injected directly in the chromatographic system. Besides the many advantages of the methodology, such as minimization of the sample volume required and its manipulation, both compounds ionized in positive and negative mode could be analyzed simultaneously without compromising the sensitivity. A comparative study of different mobile phases, gradients and LC pre-concentration columns was carried out to obtain the best analytical performance. Limits of detection (MLODs) achieved were in the low ngL(-1) range for all the compounds. The method was successfully applied to study the presence of the target analytes in different wastewater and surface water samples collected near the city of Girona (Catalonia, Spain). Data on the environmental presence and fate of pharmaceutical metabolites and TPs is still scarce, highlighting the relevance of the developed methodology.

  16. HANSIS software tool for the automated analysis of HOLZ lines.

    PubMed

    Holec, D; Sridhara Rao, D V; Humphreys, C J

    2009-06-01

    A software tool, named as HANSIS (HOLZ analysis), has been developed for the automated analysis of higher-order Laue zone (HOLZ) lines in convergent beam electron diffraction (CBED) patterns. With this tool, the angles and distances between the HOLZ intersections can be measured and the data can be presented graphically with a user-friendly interface. It is capable of simultaneous analysis of several HOLZ patterns and thus provides a tool for systematic studies of CBED patterns.

  17. Advanced DFM application for automated bit-line pattern dummy

    NASA Astrophysics Data System (ADS)

    Shin, Tae Hyun; Kim, Cheolkyun; Yang, Hyunjo; Bahr, Mohamed

    2016-03-01

    This paper presents an automated DFM solution to generate Bit Line Pattern Dummy (BLPD) for memory devices. Dummy shapes are aligned with memory functional bits to ensure uniform and reliable memory device. This paper will present a smarter approach that uses an analysis based technique for adding the dummy shapes that have different types according to the space available. Experimental results based on layout of Mobile dynamic random access memory (DRAM).

  18. Towards an automated intelligence product generation capability

    NASA Astrophysics Data System (ADS)

    Smith, Alison M.; Hawes, Timothy W.; Nolan, James J.

    2015-05-01

    Creating intelligence information products is a time consuming and difficult process for analysts faced with identifying key pieces of information relevant to a complex set of information requirements. Complicating matters, these key pieces of information exist in multiple modalities scattered across data stores, buried in huge volumes of data. This results in the current predicament analysts find themselves; information retrieval and management consumes huge amounts of time that could be better spent performing analysis. The persistent growth in data accumulation rates will only increase the amount of time spent on these tasks without a significant advance in automated solutions for information product generation. We present a product generation tool, Automated PrOduct Generation and Enrichment (APOGEE), which aims to automate the information product creation process in order to shift the bulk of the analysts' effort from data discovery and management to analysis. APOGEE discovers relevant text, imagery, video, and audio for inclusion in information products using semantic and statistical models of unstructured content. APOGEEs mixed-initiative interface, supported by highly responsive backend mechanisms, allows analysts to dynamically control the product generation process ensuring a maximally relevant result. The combination of these capabilities results in significant reductions in the time it takes analysts to produce information products while helping to increase the overall coverage. Through evaluation with a domain expert, APOGEE has been shown the potential to cut down the time for product generation by 20x. The result is a flexible end-to-end system that can be rapidly deployed in new operational settings.

  19. Army Software Product Line Workshop

    DTIC Science & Technology

    2009-02-12

    2009 Carnegie Mellon University Linda Northrop Director Research, Technology , and System Solutions Program Software Engineering Institute Carnegie...Acquisition Support (ASP) Research, Technology , and System Solutions (RTSS) • Architecture-Centric Engineering • Product Line Practice • System of... Technology , and System Solutions (RTSS) • Architecture-Centric Engineering • Product Line Practice • System of Systems Practice • System of Systems

  20. An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products

    PubMed Central

    Johnston, Chad W.; Skinnider, Michael A.; Wyatt, Morgan A.; Li, Xiang; Ranieri, Michael R. M.; Yang, Lian; Zechel, David L.; Ma, Bin; Magarvey, Nathan A.

    2015-01-01

    Bacterial natural products are a diverse and valuable group of small molecules, and genome sequencing indicates that the vast majority remain undiscovered. The prediction of natural product structures from biosynthetic assembly lines can facilitate their discovery, but highly automated, accurate, and integrated systems are required to mine the broad spectrum of sequenced bacterial genomes. Here we present a genome-guided natural products discovery tool to automatically predict, combinatorialize and identify polyketides and nonribosomal peptides from biosynthetic assembly lines using LC–MS/MS data of crude extracts in a high-throughput manner. We detail the directed identification and isolation of six genetically predicted polyketides and nonribosomal peptides using our Genome-to-Natural Products platform. This highly automated, user-friendly programme provides a means of realizing the potential of genetically encoded natural products. PMID:26412281

  1. Process development for automated solar cell and module production. Task 4: Automated array assembly

    NASA Technical Reports Server (NTRS)

    1980-01-01

    A process sequence which can be used in conjunction with automated equipment for the mass production of solar cell modules for terrestrial use was developed. The process sequence was then critically analyzed from a technical and economic standpoint to determine the technological readiness of certain process steps for implementation. The steps receiving analysis were: back contact metallization, automated cell array layup/interconnect, and module edge sealing. For automated layup/interconnect, both hard automation and programmable automation (using an industrial robot) were studied. The programmable automation system was then selected for actual hardware development.

  2. Automation and control of off-planet oxygen production processes

    NASA Technical Reports Server (NTRS)

    Marner, W. J.; Suitor, J. W.; Schooley, L. S.; Cellier, F. E.

    1990-01-01

    This paper addresses several aspects of the automation and control of off-planet production processes. First, a general approach to process automation and control is discussed from the viewpoint of translating human process control procedures into automated procedures. Second, the control issues for the automation and control of off-planet oxygen processes are discussed. Sensors, instruments, and components are defined and discussed in the context of off-planet applications, and the need for 'smart' components is clearly established.

  3. Weld line detection and process control for welding automation

    NASA Astrophysics Data System (ADS)

    Yang, Sang-Min; Cho, Man-Ho; Lee, Ho-Young; Cho, Taik-Dong

    2007-03-01

    Welding has been widely used as a process to join metallic parts. But because of hazardous working conditions, workers tend to avoid this task. Techniques to achieve the automation are the recognition of joint line and process control. A CCD (charge coupled device) camera with a laser stripe was applied to enhance the automatic weld seam tracking in GMAW (gas metal arc welding). The adaptive Hough transformation having an on-line processing ability was used to extract laser stripes and to obtain specific weld points. The three-dimensional information obtained from the vision system made it possible to generate the weld torch path and to obtain information such as the width and depth of the weld line. In this study, a neural network based on the generalized delta rule algorithm was adapted to control the process of GMAW, such as welding speed, arc voltage and wire feeding speed. The width and depth of the weld joint have been selected as neurons in the input layer of the neural-network algorithm. The input variables, the width and depth of the weld joint, are determined by image information. The voltage, weld speed and wire feed rate are represented as the neurons in the output layer. The results of the neural-network learning applied to the welding are as follows: learning ratio 0.5, momentum ratio 0.7, the number of hidden layers 2 and the number of hidden units 8. They have significant influence on the weld quality.

  4. Process development for automated solar cell and module production. Task 4: automated array assembly

    SciTech Connect

    Hagerty, J.J.

    1980-06-30

    The scope of work under this contract involves specifying a process sequence which can be used in conjunction with automated equipment for the mass production of solar cell modules for terrestrial use. This process sequence is then critically analyzed from a technical and economic standpoint to determine the technological readiness of each process step for implementation. The process steps are ranked according to the degree of development effort required and according to their significance to the overall process. Under this contract the steps receiving analysis were: back contact metallization, automated cell array layup/interconnect, and module edge sealing. For automated layup/interconnect both hard automation and programmable automation (using an industrial robot) were studied. The programmable automation system was then selected for actual hardware development. Economic analysis using the SAMICS system has been performed during these studies to assure that development efforts have been directed towards the ultimate goal of price reduction. Details are given. (WHK)

  5. Automation of (64)Cu production at Turku PET Centre.

    PubMed

    Elomaa, Viki-Veikko; Jurttila, Jori; Rajander, Johan; Solin, Olof

    2014-07-01

    At Turku PET Centre automation for handling solid targets for the production of (64)Cu has been built. The system consists of a module for moving the target from the irradiation position into a lead transport shield and a robotic-arm assisted setup for moving the target within radiochemistry laboratory. The main motivation for designing automation arises from radiation hygiene.

  6. A high-throughput automated platform for the development of manufacturing cell lines for protein therapeutics.

    PubMed

    Shi, Shuangping; Condon, Russ G G; Deng, Liang; Saunders, Jason; Hung, Finn; Tsao, Yung-Shyeng; Liu, Zhong

    2011-09-22

    The fast-growing biopharmaceutical industry demands speedy development of highly efficient and reliable production systems to meet the increasing requirement for drug supplies. The generation of production cell lines has traditionally involved manual operations that are labor-intensive, low-throughput and vulnerable to human errors. We report here an integrated high-throughput and automated platform for development of manufacturing cell lines for the production of protein therapeutics. The combination of BD FACS Aria Cell Sorter, CloneSelect Imager and TECAN Freedom EVO liquid handling system has enabled a high-throughput and more efficient cell line development process. In this operation, production host cells are first transfected with an expression vector carrying the gene of interest (1), followed by the treatment with a selection agent. The stably-transfected cells are then stained with fluorescence-labeled anti-human IgG antibody, and are subsequently subject to flow cytometry analysis (2-4). Highly productive cells are selected based on fluorescence intensity and are isolated by single-cell sorting on a BD FACSAria. Colony formation from single-cell stage was detected microscopically and a series of time-laps digital images are taken by CloneSelect Imager for the documentation of cell line history. After single clones have formed, these clones were screened for productivity by ELISA performed on a TECAN Freedom EVO liquid handling system. Approximately 2,000 - 10,000 clones can be screened per operation cycle with the current system setup. This integrated approach has been used to generate high producing Chinese hamster ovary (CHO) cell lines for the production of therapeutic monoclonal antibody (mAb) as well as their fusion proteins. With the aid of different types of detecting probes, the method can be used for developing other protein therapeutics or be applied to other production host systems. Comparing to the traditional manual procedure, this automated

  7. Automated systems to identify relevant documents in product risk management

    PubMed Central

    2012-01-01

    Background Product risk management involves critical assessment of the risks and benefits of health products circulating in the market. One of the important sources of safety information is the primary literature, especially for newer products which regulatory authorities have relatively little experience with. Although the primary literature provides vast and diverse information, only a small proportion of which is useful for product risk assessment work. Hence, the aim of this study is to explore the possibility of using text mining to automate the identification of useful articles, which will reduce the time taken for literature search and hence improving work efficiency. In this study, term-frequency inverse document-frequency values were computed for predictors extracted from the titles and abstracts of articles related to three tumour necrosis factors-alpha blockers. A general automated system was developed using only general predictors and was tested for its generalizability using articles related to four other drug classes. Several specific automated systems were developed using both general and specific predictors and training sets of different sizes in order to determine the minimum number of articles required for developing such systems. Results The general automated system had an area under the curve value of 0.731 and was able to rank 34.6% and 46.2% of the total number of 'useful' articles among the first 10% and 20% of the articles presented to the evaluators when tested on the generalizability set. However, its use may be limited by the subjective definition of useful articles. For the specific automated system, it was found that only 20 articles were required to develop a specific automated system with a prediction performance (AUC 0.748) that was better than that of general automated system. Conclusions Specific automated systems can be developed rapidly and avoid problems caused by subjective definition of useful articles. Thus the efficiency of

  8. Automation Framework for Flight Dynamics Products Generation

    NASA Technical Reports Server (NTRS)

    Wiegand, Robert E.; Esposito, Timothy C.; Watson, John S.; Jun, Linda; Shoan, Wendy; Matusow, Carla

    2010-01-01

    XFDS provides an easily adaptable automation platform. To date it has been used to support flight dynamics operations. It coordinates the execution of other applications such as Satellite TookKit, FreeFlyer, MATLAB, and Perl code. It provides a mechanism for passing messages among a collection of XFDS processes, and allows sending and receiving of GMSEC messages. A unified and consistent graphical user interface (GUI) is used for the various tools. Its automation configuration is stored in text files, and can be edited either directly or using the GUI.

  9. Process development for automated solar cell and module production. Task 4: Automated array assembly

    NASA Technical Reports Server (NTRS)

    Hagerty, J. J.

    1981-01-01

    Progress in the development of automated solar cell and module production is reported. The unimate robot is programmed for the final 35 cell pattern to be used in the fabrication of the deliverable modules. The mechanical construction of the automated lamination station and final assembly station phases are completed and the first operational testing is underway. The final controlling program is written and optimized. The glass reinforced concrete (GRC) panels to be used for testing and deliverables are in production. Test routines are grouped together and defined to produce the final control program.

  10. An Automated On-Line Circulation System; Evaluation, Development, Use.

    ERIC Educational Resources Information Center

    Hoadley, Irene Braden, Ed.; Thorson, A. Robert, Ed.

    The Ohio State Libraries hosted an institute to involve participants in a discussion of the Library Circulation System (LCS). Five papers were presented which were devoted to: (1) the historical background and philosophy surrounding the decision of The Ohio State University Libraries to involve themselves in the field of automation; (2) the…

  11. Mechanization and automation of production processes in turbine building

    NASA Astrophysics Data System (ADS)

    Slobodyanyuk, V. P.

    1984-02-01

    Specialists at the All-Union Institute of Planning and Technology of Energy Machine Building are working on the problem of mechanization and automation of production processes. One of the major technological processes being worked on is the production of welded units. At the present time the Institute has designed a centralized cutting and manufacturing shop in use at several metallurgical plants, clamping devices for materials hoists based on permanent magnets, a program controlled installation for driving shaped apertures in welded diaphragm rims and an automated system for planning technological processes involved in manufacturing operations. Even in the manufacture of such individualized devices as turbines, mechanization and automation of production processes are economically justified. During the 11th Five Year Plan, the Institute will continue to develop progressive technological processes and equipment for precise shaping of turbine blade blanks, mechanical working of parts of steam, gas and hydraulic turbines, as well as nuclear powerplant turbines.

  12. An automated system for production of 89Zr

    NASA Astrophysics Data System (ADS)

    Wooten, A. L.; Schweitzer, G. D.; Lawrence, L. A.; Madrid, E.; Lapi, S. E.

    2012-12-01

    We have developed an automated system for routine production of 89Zr. This system has automated a separation process from the literature that uses a hydroxamate resin column to purify 89Zr from an 89Y target. We have designed this system to give production personnel control over every step in the process through an easy to-use graphical user interface (GUI) that also gives step-by-step instructions for the process. This system is currently transitioning from its testing phase at low activities, so further testing and improvements are planned to increase product recovery and to improve the consistency of its product. To date production runs on the order of 10 mCi of 89Zr have been tested, and effective specific activities of 545 mCi/μmol and radionuclidic purity greater than 99.99% have been achieved.

  13. Automated Analysis of Child Phonetic Production Using Naturalistic Recordings

    ERIC Educational Resources Information Center

    Xu, Dongxin; Richards, Jeffrey A.; Gilkerson, Jill

    2014-01-01

    Purpose: Conventional resource-intensive methods for child phonetic development studies are often impractical for sampling and analyzing child vocalizations in sufficient quantity. The purpose of this study was to provide new information on early language development by an automated analysis of child phonetic production using naturalistic…

  14. Aspect-Oriented Model-Driven Software Product Line Engineering

    NASA Astrophysics Data System (ADS)

    Groher, Iris; Voelter, Markus

    Software product line engineering aims to reduce development time, effort, cost, and complexity by taking advantage of the commonality within a portfolio of similar products. The effectiveness of a software product line approach directly depends on how well feature variability within the portfolio is implemented and managed throughout the development lifecycle, from early analysis through maintenance and evolution. This article presents an approach that facilitates variability implementation, management, and tracing by integrating model-driven and aspect-oriented software development. Features are separated in models and composed of aspect-oriented composition techniques on model level. Model transformations support the transition from problem to solution space models. Aspect-oriented techniques enable the explicit expression and modularization of variability on model, template, and code level. The presented concepts are illustrated with a case study of a home automation system.

  15. Automated CD-SEM recipe creation technology for mass production using CAD data

    NASA Astrophysics Data System (ADS)

    Kawahara, Toshikazu; Yoshida, Masamichi; Tanaka, Masashi; Ido, Sanyu; Nakano, Hiroyuki; Adachi, Naokaka; Abe, Yuichi; Nagatomo, Wataru

    2011-03-01

    Critical Dimension Scanning Electron Microscope (CD-SEM) recipe creation needs sample preparation necessary for matching pattern registration, and recipe creation on CD-SEM using the sample, which hinders the reduction in test production cost and time in semiconductor manufacturing factories. From the perspective of cost reduction and improvement of the test production efficiency, automated CD-SEM recipe creation without the sample preparation and the manual operation has been important in the production lines. For the automated CD-SEM recipe creation, we have introduced RecipeDirector (RD) that enables the recipe creation by using Computer-Aided Design (CAD) data and text data that includes measurement information. We have developed a system that automatically creates the CAD data and the text data necessary for the recipe creation on RD; and, for the elimination of the manual operation, we have enhanced RD so that all measurement information can be specified in the text data. As a result, we have established an automated CD-SEM recipe creation system without the sample preparation and the manual operation. For the introduction of the CD-SEM recipe creation system using RD to the production lines, the accuracy of the pattern matching was an issue. The shape of design templates for the matching created from the CAD data was different from that of SEM images in vision. Thus, a development of robust pattern matching algorithm that considers the shape difference was needed. The addition of image processing of the templates for the matching and shape processing of the CAD patterns in the lower layer has enabled the robust pattern matching. This paper describes the automated CD-SEM recipe creation technology for the production lines without the sample preparation and the manual operation using RD applied in Sony Semiconductor Kyusyu Corporation Kumamoto Technology Center (SCK Corporation Kumamoto TEC).

  16. Automation or De-automation

    NASA Astrophysics Data System (ADS)

    Gorlach, Igor; Wessel, Oliver

    2008-09-01

    In the global automotive industry, for decades, vehicle manufacturers have continually increased the level of automation of production systems in order to be competitive. However, there is a new trend to decrease the level of automation, especially in final car assembly, for reasons of economy and flexibility. In this research, the final car assembly lines at three production sites of Volkswagen are analysed in order to determine the best level of automation for each, in terms of manufacturing costs, productivity, quality and flexibility. The case study is based on the methodology proposed by the Fraunhofer Institute. The results of the analysis indicate that fully automated assembly systems are not necessarily the best option in terms of cost, productivity and quality combined, which is attributed to high complexity of final car assembly systems; some de-automation is therefore recommended. On the other hand, the analysis shows that low automation can result in poor product quality due to reasons related to plant location, such as inadequate workers' skills, motivation, etc. Hence, the automation strategy should be formulated on the basis of analysis of all relevant aspects of the manufacturing process, such as costs, quality, productivity and flexibility in relation to the local context. A more balanced combination of automated and manual assembly operations provides better utilisation of equipment, reduces production costs and improves throughput.

  17. Automation in Animal Housing and Production

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Intensive, controlled environment animal production began modestly in the mid-20th century as poultry were brought indoors. While mankind had utilized structures to provide shelter for their animals for centuries, the availability of relatively inexpensive energy and the electrification of rural are...

  18. Performance evaluation of the croissant production line with reparable machines

    NASA Astrophysics Data System (ADS)

    Tsarouhas, Panagiotis H.

    2015-09-01

    In this study, the analytical probability models for an automated serial production system, bufferless that consists of n-machines in series with common transfer mechanism and control system was developed. Both time to failure and time to repair a failure are assumed to follow exponential distribution. Applying those models, the effect of system parameters on system performance in actual croissant production line was studied. The production line consists of six workstations with different numbers of reparable machines in series. Mathematical models of the croissant production line have been developed using Markov process. The strength of this study is in the classification of the whole system in states, representing failures of different machines. Failure and repair data from the actual production environment have been used to estimate reliability and maintainability for each machine, workstation, and the entire line is based on analytical models. The analysis provides a useful insight into the system's behaviour, helps to find design inherent faults and suggests optimal modifications to upgrade the system and improve its performance.

  19. Performance evaluation of the croissant production line with reparable machines

    NASA Astrophysics Data System (ADS)

    Tsarouhas, Panagiotis H.

    2014-09-01

    In this study, the analytical probability models for an automated serial production system, bufferless that consists of n-machines in series with common transfer mechanism and control system was developed. Both time to failure and time to repair a failure are assumed to follow exponential distribution. Applying those models, the effect of system parameters on system performance in actual croissant production line was studied. The production line consists of six workstations with different numbers of reparable machines in series. Mathematical models of the croissant production line have been developed using Markov process. The strength of this study is in the classification of the whole system in states, representing failures of different machines. Failure and repair data from the actual production environment have been used to estimate reliability and maintainability for each machine, workstation, and the entire line is based on analytical models. The analysis provides a useful insight into the system's behaviour, helps to find design inherent faults and suggests optimal modifications to upgrade the system and improve its performance.

  20. Development of a Production Ready Automated Wire Delivery System

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The current development effort is a Phase 3 research study entitled "A Production Ready Automated Wire Delivery System", contract number NAS8-39933, awarded to Nichols Research Corporation (NRC). The goals of this research study were to production harden the existing Automated Wire Delivery (AWDS) motion and sensor hardware and test the modified AWDS in a range of welding applications. In addition, the prototype AWDS controller would be moved to the VME bus platform by designing, fabricating and testing a single board VME bus AWDS controller. This effort was to provide an AWDS that could transition from the laboratory environment to production operations. The project was performed in two development steps. Step 1 modified and tested an improved MWG. Step 2 developed and tested the AWDS single board VME bus controller. Step 3 installed the Wire Pilot in a Weld Controller with the imbedded VME bus controller.

  1. Human Communication Needs and Organizational Productivity: The Potential Impact of Office Automation.

    ERIC Educational Resources Information Center

    Culnan, Mary J.; Bair, James H.

    1983-01-01

    This survey of potential impacts of office automation on organizational communication and productivity covers the following--(1) the relationship between office automation and organizational communication; (2) communication variables relevant to office automation; (3) benefits and caveats related to implementation of office automation. Thirty-four…

  2. Automated defect cross-sectioning with an in-line DualBeam

    NASA Astrophysics Data System (ADS)

    Blanc-Coquand, Stephanie; Hinschberger, Benoit; Rouchouze, Eric; Sicurani, Emmanuel; Castagna, Marc; Weschler, Matthew; Dworkin, Larry; Renard, Didier; Panyasak, Atsavinn

    2004-05-01

    Shrinking design rules and the introduction of new materials and processes in the formation of Cu interconnects in damascene modules have given rise to new and previously unknown killer defect mechanisms. These failure mechanisms are very challenging to detect, identify, and eliminate. The ability to characterize buried defects, such as defective vias, previous layer defects, or integration issues detected by optical defect inspection tools as well as electron-beam inspection tools has become mandatory. Out of the several cross-section tools available to the lab, the one that best addresses the in-line applications requirements is known as the DualBeam (FIB/SEM). The ion beam allows cross-sectioning while a coincident electron beam allows for high resolution imaging of the cross-section. Using the FEI Defect Analyzer 300 DualBeam system, this process has been automated for in-line usage. Defects can be navigated to using defect files generated by the inspection tools. The wafer production line is now enabled to easily mill cross sections in-line and determine root causes, something that is often not possible from top down information alone. For volume in-line use on defects, additional requirements must also be met: compatibility with clean room environment, navigation on full wafers to relocate the defects detected by the inspection tools, throughput, ease of use, low impact on wafers so that they can be returned to the line. All of this must allow the gathering of data at numerous cross-sections on buried defects in order to perform the same type of Pareto analysis as is traditionally done after defect review of top-down visible defects. Example use cases will be presented to demonstrate how this methodology is being developed in a manufacturing environment to help understand previously unexplained yield losses and to deliver results with a rapid response time. Applications on defects detected with electron beam inspection in copper or tungsten interconnects

  3. Fully automated production of iodine-124 using a vertical beam.

    PubMed

    Nagatsu, Kotaro; Fukada, Masami; Minegishi, Katsuyuki; Suzuki, Hisashi; Fukumura, Toshimitsu; Yamazaki, Hiromichi; Suzuki, Kazutoshi

    2011-01-01

    A fully automated system for the production of iodine-124, based on techniques of vertical-beam irradiation and dry distillation, was developed. The system, coupled with a capsulated target, was able to irradiate the (124)TeO(2) target up to 29 μA for 1-4h, which yielded iodine-124 with an almost constant yield of 6.9 MBq/μAh at the end of bombardment. All procedures were performed automatically and repeatedly. The newly developed system would be suitable for routine, large-scale productions of iodine-124.

  4. Automated Production of Movies on a Cluster of Computers

    NASA Technical Reports Server (NTRS)

    Nail, Jasper; Le, Duong; Nail, William L.; Nail, William

    2008-01-01

    A method of accelerating and facilitating production of video and film motion-picture products, and software and generic designs of computer hardware to implement the method, are undergoing development. The method provides for automation of most of the tedious and repetitive tasks involved in editing and otherwise processing raw digitized imagery into final motion-picture products. The method was conceived to satisfy requirements, in industrial and scientific testing, for rapid processing of multiple streams of simultaneously captured raw video imagery into documentation in the form of edited video imagery and video derived data products for technical review and analysis. In the production of such video technical documentation, unlike in production of motion-picture products for entertainment, (1) it is often necessary to produce multiple video derived data products, (2) there are usually no second chances to repeat acquisition of raw imagery, (3) it is often desired to produce final products within minutes rather than hours, days, or months, and (4) consistency and quality, rather than aesthetics, are the primary criteria for judging the products. In the present method, the workflow has both serial and parallel aspects: processing can begin before all the raw imagery has been acquired, each video stream can be subjected to different stages of processing simultaneously on different computers that may be grouped into one or more cluster(s), and the final product may consist of multiple video streams. Results of processing on different computers are shared, so that workers can collaborate effectively.

  5. Soliton production with nonlinear homogeneous lines

    DOE PAGES

    Elizondo-Decanini, Juan M.; Coleman, Phillip D.; Moorman, Matthew W.; ...

    2015-11-24

    Low- and high-voltage Soliton waves were produced and used to demonstrate collision and compression using diode-based nonlinear transmission lines. Experiments demonstrate soliton addition and compression using homogeneous nonlinear lines. We built the nonlinear lines using commercially available diodes. These diodes are chosen after their capacitance versus voltage dependence is used in a model and the line design characteristics are calculated and simulated. Nonlinear ceramic capacitors are then used to demonstrate high-voltage pulse amplification and compression. The line is designed such that a simple capacitor discharge, input signal, develops soliton trains in as few as 12 stages. We also demonstrated outputmore » voltages in excess of 40 kV using Y5V-based commercial capacitors. The results show some key features that determine efficient production of trains of solitons in the kilovolt range.« less

  6. Soliton production with nonlinear homogeneous lines

    SciTech Connect

    Elizondo-Decanini, Juan M.; Coleman, Phillip D.; Moorman, Matthew W.; Petney, Sharon Joy Victor; Dudley, Evan C.; Youngman, Kevin; Penner, Tim Dwight; Fang, Lu; Myers, Katherine M.

    2015-11-24

    Low- and high-voltage Soliton waves were produced and used to demonstrate collision and compression using diode-based nonlinear transmission lines. Experiments demonstrate soliton addition and compression using homogeneous nonlinear lines. We built the nonlinear lines using commercially available diodes. These diodes are chosen after their capacitance versus voltage dependence is used in a model and the line design characteristics are calculated and simulated. Nonlinear ceramic capacitors are then used to demonstrate high-voltage pulse amplification and compression. The line is designed such that a simple capacitor discharge, input signal, develops soliton trains in as few as 12 stages. We also demonstrated output voltages in excess of 40 kV using Y5V-based commercial capacitors. The results show some key features that determine efficient production of trains of solitons in the kilovolt range.

  7. Automate it: ligand-binding assay productivity in a discovery bioanalytical setting.

    PubMed

    Leung, Sheldon S; Dreher, Elizabeth A

    2013-07-01

    In multiple industries, including the biopharmaceutical industry, automation is synonymous with increased productivity. Environments with high-throughput needs commonly employ automation for efficiency. However, in a discovery bioanalytical ligand-binding assay laboratory setting where the focus is not necessarily on sample analysis throughput, but instead on assay development and characterization, is automation applicable? Can automation enhance productivity when tasks are more customized than routine? In this Perspective we review the different categories of automation with ligand-binding assays with these questions in mind. In considering whether automation technology has progressed far enough to result in a positive return in investment in the discovery setting, the resource investment required to operate in this space was contrasted with the gain in productivity. In our opinion, technology advancements in automated technology platforms, and especially personal automation, have allowed these categories to strike the right balance for investment in the discovery laboratory setting.

  8. Automation and robotics - Key to productivity. [in industry and space

    NASA Technical Reports Server (NTRS)

    Cohen, A.

    1985-01-01

    The automated and robotic systems requirements of the NASA Space Station are prompted by maintenance, repair, servicing and assembly requirements. Trend analyses, fault diagnoses, and subsystem status assessments for the Station's electrical power, guidance, navigation, control, data management and environmental control subsystems will be undertaken by cybernetic expert systems; this will reduce or eliminate on-board or ground facility activities that would otherwise be essential, enhancing system productivity. Additional capabilities may also be obtained through the incorporation of even a limited amount of artificial intelligence in the controllers of the various Space Station systems.

  9. Production evaluation of automated reticle defect printability prediction application

    NASA Astrophysics Data System (ADS)

    Howard, William B.; Pomeroy, Scott; Moses, Raphael; Thaler, Thomas

    2007-02-01

    The growing complexity of reticles and continual tightening of defect specifications causes the reticle defect disposition function to become increasingly difficult. No longer can defect specifications be distilled to a single number, nor can past simple classification rules be employed due to the effects of MEEF on actual printing behavior. The mask maker now requires lithography-based rules and capabilities for making these go/no-go decisions at the reticle inspection step. We have evaluated an automated system that predicts the lithographic significance of reticle defects using PROLITHTM technology. This printability prediction tool was evaluated and tested in a production environment using both standard test reticles and production samples in an advanced reticle manufacturing environment. Reference measurements on Zeiss AIMSTM systems were used to assess the accuracy of predicted results. The application, called the Automated Mask Defect Disposition System, or AMDD, models defective and non-defective test and reference images generated by a high-resolution inspection system. The results were calculated according to the wafer exposure conditions given at setup such that the reticle could be judged for its 'fitness-for-use' from a lithographic standpoint rather than from a simple physical measurement of the film materials. We present the methods and empirical results comparing 1D and 2D Intensity Difference Metrics (IDMs) with respect to AIMS and discuss the results of usability and productivity studies as they apply to manufacturing environments.

  10. The Future of Product Line Development at NASA

    NASA Technical Reports Server (NTRS)

    Lutz, Robyn R.

    2006-01-01

    This viewgraph presentation reviews NASA's software production in the light of a product line similar to a commercial product line. The authors propose to identify, investigate, evaluate and apply product-line engineering techniques to NASA's product lines in order to improve the timeliness, robustness and effectiveness of these future systems.

  11. Lutetium-177 DOTATATE Production with an Automated Radiopharmaceutical Synthesis System

    PubMed Central

    Aslani, Alireza; Snowdon, Graeme M; Bailey, Dale L; Schembri, Geoffrey P; Bailey, Elizabeth A; Pavlakis, Nick; Roach, Paul J

    2015-01-01

    Objective(s): Peptide Receptor Radionuclide Therapy (PRRT) with yttrium-90 (90Y) and lutetium-177 (177Lu)-labelled SST analogues are now therapy option for patients who have failed to respond to conventional medical therapy. In-house production with automated PRRT synthesis systems have clear advantages over manual methods resulting in increasing use in hospital-based radiopharmacies. We report on our one year experience with an automated radiopharmaceutical synthesis system. Methods: All syntheses were carried out using the Eckert & Ziegler Eurotope’s Modular-Lab Pharm Tracer® automated synthesis system. All materials and methods used were followed as instructed by the manufacturer of the system (Eckert & Ziegler Eurotope, Berlin, Germany). Sterile, GMP-certified, no-carrier added (NCA) 177Lu was used with GMP-certified peptide. An audit trail was also produced and saved by the system. The quality of the final product was assessed after each synthesis by ITLC-SG and HPLC methods. Results: A total of 17 [177Lu]-DOTATATE syntheses were performed between August 2013 and December 2014. The amount of radioactive [177Lu]-DOTATATE produced by each synthesis varied between 10-40 GBq and was dependant on the number of patients being treated on a given day. Thirteen individuals received a total of 37 individual treatment administrations in this period. There were no issues and failures with the system or the synthesis cassettes. The average radiochemical purity as determined by ITLC was above 99% (99.8 ± 0.05%) and the average radiochemical purity as determined by HPLC technique was above 97% (97.3 ± 1.5%) for this period. Conclusions: The automated synthesis of [177Lu]-DOTATATE using Eckert & Ziegler Eurotope’s Modular-Lab Pharm Tracer® system is a robust, convenient and high yield approach to the radiolabelling of DOTATATE peptide benefiting from the use of NCA 177Lu and almost negligible radiation exposure of the operators. PMID:27408890

  12. Streamlining workflow and automation to accelerate laboratory scale protein production.

    PubMed

    Konczal, Jennifer; Gray, Christopher H

    2017-03-19

    Protein production facilities are often required to produce diverse arrays of proteins for demanding methodologies including crystallography, NMR, ITC and other reagent intensive techniques. It is common for these teams to find themselves a bottleneck in the pipeline of ambitious projects. This pressure to deliver has resulted in the evolution of many novel methods to increase capacity and throughput at all stages in the pipeline for generation of recombinant proteins. This review aims to describe current and emerging options to accelerate the success of protein production in Escherichia coli. We emphasize technologies that have been evaluated and implemented in our laboratory, including innovative molecular biology and expression vectors, small-scale expression screening strategies and the automation of parallel and multidimensional chromatography.

  13. A power line data communication interface using spread spectrum technology in home automation

    SciTech Connect

    Shwehdi, M.H.; Khan, A.Z.

    1996-07-01

    Building automation technology is rapidly developing towards more reliable communication systems, devices that control electronic equipments. These equipment if controlled leads to efficient energy management, and savings on the monthly electricity bill. Power Line communication (PLC) has been one of the dreams of the electronics industry for decades, especially for building automation. It is the purpose of this paper to demonstrate communication methods among electronic control devices through an AC power line carrier within the buildings for more efficient energy control. The paper outlines methods of communication over a powerline, namely the X-10 and CE bus. It also introduces the spread spectrum technology as to increase speed to 100--150 times faster than the X-10 system. The powerline carrier has tremendous applications in the field of building automation. The paper presents an attempt to realize a smart house concept, so called, in which all home electronic devices from a coffee maker to a water heater microwave to chaos robots will be utilized by an intelligent network whenever one wishes to do so. The designed system may be applied very profitably to help in energy management for both customer and utility.

  14. On the Automated and Objective Detection of Emission Lines in Faint-Object Spectroscopy

    NASA Astrophysics Data System (ADS)

    Hong, Sungryong; Dey, Arjun; Prescott, Moire K. M.

    2014-11-01

    Modern spectroscopic surveys produce large spectroscopic databases, generally with sizes well beyond the scope of manual investigation. The need arises, therefore, for an automated line detection method with objective indicators for detection significance. In this paper, we present an automated and objective method for emission line detection in spectroscopic surveys and apply this technique to 1574 spectra, obtained with the Hectospec spectrograph on the MMT Observatory (MMTO), to detect Lyman alpha emitters near z ~ 2.7. The basic idea is to generate on-source (signal plus noise) and off-source (noise only) mock observations using Monte Carlo simulations, and calculate completeness and reliability values, (C, R), for each simulated signal. By comparing the detections from real data with the Monte Carlo results, we assign the completeness and reliability values to each real detection. From 1574 spectra, we obtain 881 raw detections and, by removing low reliability detections, we finalize 649 detections from an automated pipeline. Most of high completeness and reliability detections, (C, R) ~ (1.0, 1.0), are robust detections when visually inspected; the low C and R detections are also marginal on visual inspection. This method at detecting faint sources is dependent on the accuracy of the sky subtraction.

  15. Design of Control System for Flexible Packaging Bags Palletizing Production Line Based on PLC

    NASA Astrophysics Data System (ADS)

    Zheng, Huiping; Chen, Lin; Zhao, Xiaoming; Liu, Zhanyang

    Flexible packaging bags palletizing production line is to put the bags in the required area according to particular order and size, in order to finish handling, storage, loading and unloading, transportation and other logistics work of goods. Flexible packaging bags palletizing line is composed of turning bags mechanism, shaping mechanism, indexing mechanism, marshalling mechanism, pushing bags mechanism, pressing bags mechanism, laminating mechanism, elevator, tray warehouse, tray conveyor and loaded tray conveyor. Whether the whole production line can smoothly run depends on each of the above equipment and precision control among them. In this paper the technological process and the control logic of flexible packaging bags palletizing production line is introduced. Palletizing process of the production line realized automation by means of a control system based on programmable logic controller (PLC). It has the advantages of simple structure, reliable and easy maintenance etc.

  16. XP Workshop on Agile Product Line Engineering

    NASA Astrophysics Data System (ADS)

    Ghanam, Yaser; Cooper, Kendra; Abrahamsson, Pekka; Maurer, Frank

    Software Product Line Engineering (SPLE) promises to lower the costs of developing individual applications as they heavily reuse existing artifacts. Besides decreasing costs, software reuse achieves faster development and higher quality. Traditionally, SPLE favors big design upfront and employs traditional, heavy weight processes. On the other hand, agile methods have been proposed to rapidly develop high quality software by focusing on producing working code while reducing upfront analysis and design. Combining both paradigms, although is challenging, can yield significant improvements.

  17. Introduction to Software Product Lines (Slides)

    DTIC Science & Technology

    2014-10-01

    2014 by Carnegie Mellon University Software Engineering Institute Carnegie Mellon University Pittsburgh, PA 15213 Introduction to...valid OMB control number. 1. REPORT DATE 01 OCT 2014 2. REPORT TYPE N/A 3. DATES COVERED 4. TITLE AND SUBTITLE Introduction to Software...298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 © 2014 Carnegie Mellon University Introduction to Software Product Lines 2 Copyright 2014 Carnegie

  18. Industrial tomato lines: morphological properties and productivity.

    PubMed

    Peixoto, J V M; Neto, C de M S; Campos, L F C; Dourado, W de S; Nogueira, A P O; Nascimento, A Dos R

    2017-04-13

    The tomato is the second most produced vegetable in the world, with significant participation in the human diet. In addition, the production of tomatoes generates jobs and family income. The availability of improved cultivars that provide greater profitability to the producer and satisfactorily meets the needs of the fresh fruit market and the processing industry becomes imperative due to its importance. Therefore, this study aimed to characterize and select industrial tomato lines in regard to fruit yield, number of leaf branches, and number of flower racemes (NFR). The experiment was conducted in 2014 in the experimental area of the Federal University of Goiás (Universidade Federal de Goiás). The design was a randomized block design with four replicates and 25 genotypes. The number of leaf branches (NB), NFR, and fruit productivity were evaluated. The results were analyzed using analysis of variance and the means compared by the Tukey test. A difference was observed (P ≤ 0.01) for all traits analyzed. The NB and NFR were related, where more branches promoted an increase in NFR and thus the productivity increases. In addition, a greater number of fruits implied in smaller fruit size, and consequently lower fruit mass. The lowest number of fruit per plant caused increased fruit size and mass. The lines CVR 1, CVR 3, CVR 4, CVR 5, CVR 21, and CVR 22 were suitable for genetic enhancement of tomato and provided the greatest productivity.

  19. Automated genome mining of ribosomal peptide natural products

    SciTech Connect

    Mohimani, Hosein; Kersten, Roland; Liu, Wei; Wang, Mingxun; Purvine, Samuel O.; Wu, Si; Brewer, Heather M.; Pasa-Tolic, Ljiljana; Bandeira, Nuno; Moore, Bradley S.; Pevzner, Pavel A.; Dorrestein, Pieter C.

    2014-07-31

    Ribosomally synthesized and posttranslationally modified peptides (RiPPs), especially from microbial sources, are a large group of bioactive natural products that are a promising source of new (bio)chemistry and bioactivity (1). In light of exponentially increasing microbial genome databases and improved mass spectrometry (MS)-based metabolomic platforms, there is a need for computational tools that connect natural product genotypes predicted from microbial genome sequences with their corresponding chemotypes from metabolomic datasets. Here, we introduce RiPPquest, a tandem mass spectrometry database search tool for identification of microbial RiPPs and apply it for lanthipeptide discovery. RiPPquest uses genomics to limit search space to the vicinity of RiPP biosynthetic genes and proteomics to analyze extensive peptide modifications and compute p-values of peptide-spectrum matches (PSMs). We highlight RiPPquest by connection of multiple RiPPs from extracts of Streptomyces to their gene clusters and by the discovery of a new class III lanthipeptide, informatipeptin, from Streptomyces viridochromogenes DSM 40736 as the first natural product to be identified in an automated fashion by genome mining. The presented tool is available at cy-clo.ucsd.edu.

  20. WARP (workflow for automated and rapid production): a framework for end-to-end automated digital print workflows

    NASA Astrophysics Data System (ADS)

    Joshi, Parag

    2006-02-01

    Publishing industry is experiencing a major paradigm shift with the advent of digital publishing technologies. A large number of components in the publishing and print production workflow are transformed in this shift. However, the process as a whole requires a great deal of human intervention for decision making and for resolving exceptions during job execution. Furthermore, a majority of the best-of-breed applications for publishing and print production are intrinsically designed and developed to be driven by humans. Thus, the human-intensive nature of the current prepress process accounts for a very significant amount of the overhead costs in fulfillment of jobs on press. It is a challenge to automate the functionality of applications built with the model of human driven exectution. Another challenge is to orchestrate various components in the publishing and print production pipeline such that they work in a seamless manner to enable the system to perform automatic detection of potential failures and take corrective actions in a proactive manner. Thus, there is a great need for a coherent and unifying workflow architecture that streamlines the process and automates it as a whole in order to create an end-to-end digital automated print production workflow that does not involve any human intervention. This paper describes an architecture and building blocks that lay the foundation for a plurality of automated print production workflows.

  1. Process Development for Automated Solar Cell and Module Production. Task 4: Automated Array Assembly

    NASA Technical Reports Server (NTRS)

    Hagerty, J. J.

    1981-01-01

    The Automated Lamination Station is mechanically complete and is currently undergoing final wiring. The high current driver and isolator boards have been completed and installed, and the main interface board is under construction. The automated vacuum chamber has had a minor redesign to increase stiffness and improve the cover open/close mechanism. Design of the Final Assembly Station has been completed and construction is underway.

  2. Automating Mapping Production for the Enterprise: from Contract to Delivery

    NASA Astrophysics Data System (ADS)

    Uebbing, R.; Xie, C.; Beshah, B.; Welter, J.

    2012-07-01

    The ever increasing volume and quality of geospatial data has created new challenges for mapping companies. Due to increased image resolution, fusion of different data sources and more frequent data update requirements, mapping production is forced to streamline the work flow to meet client deadlines. But the data volume alone is not the only barrier for an efficient production work flow. Processing geospatial information traditionally uses domain and vendor specific applications that do not interface with each other, often leading to data duplication and therefore creating sources for error. Also, it creates isolation between different departments within a mapping company resulting in additional communication barriers. North West Geomatics has designed and implemented a data centric enterprise solution for the flight acquisition and production work flow to combat the above challenges. A central data repository containing not only geospatial data in the strictest sense such as images, vector layers and 3D point clouds, but also other information such as product specifications, client requirements, flight acquisition data, production resource usage and much more has been deployed at the company. As there is only one instance of the database shared throughout the whole organization it allows all employees, given they have been granted the appropriate permission, to view the current status of any project with a graphical and table based interface through its life cycle from sales, through flight acquisition, production and product delivery. Not only can users track progress and status of various work flow steps, but the system also allows users and applications to actively schedule or start specific production steps such as data ingestion and triangulation with many other steps (orthorectification, mosaicing, accounting, etc.) in the planning stages. While the complete system is exposed to the users through a web interface and therefore allowing outside customers to

  3. Improving laser system productivity through production line integration

    NASA Astrophysics Data System (ADS)

    Belforte, David A.

    1994-09-01

    Thousands of laser systems are employed profitably in a variety of industrial applications. These installations have proved successful for economic and technical reasons. And, in certain applications: ceramic scribing, resistor trimming, sheet metal cutting, and air foil drilling, for example, have become the industry standard. Most of these installations are free standing or, at best, part of an off-line manufacturing cell. Examples of laser systems fully integrated into a production line, where the laser process is synchronized with up and down stream manufacturing operation, are rare. The laser has been under utilized in its potential contribution to production line productivity. Current development in laser beam delivery: multiplexing, beam splitting and other distributed energy concepts make the laser an attractive option for just-in-time manufacturing operations. The reasons for this apparent neglect of the laser's full potential are reviewed in this paper, and suggestions for improvement of this situation are offered. Examples of fully integrated laser systems and their successful implementation are described and a forecast of changes in the way lasers contribute to improved productivity and profitability will be made.

  4. Stakeholder Views of Nanosilver Linings: Macroethics Education and Automated Text Analysis Through Participatory Governance Role Play in a Workshop Format.

    PubMed

    Dempsey, Joshua; Stamets, Justin; Eggleson, Kathleen

    2016-07-12

    The Nanosilver Linings role play case offers participants first-person experience with interpersonal interaction in the context of the wicked problems of emerging technology macroethics. In the fictional scenario, diverse societal stakeholders convene at a town hall meeting to consider whether a nanotechnology-enabled food packaging industry should be offered incentives to establish an operation in their economically struggling Midwestern city. This original creative work was built with a combination of elements, selected for their established pedagogical efficacy (e.g. active learning, case-based learning) and as topical dimensions of the realistic scenario (e.g. nanosilver in food packaging, occupational safety and health). The product life cycle is used as a framework for integrated consideration of scientific, societal, and ethical issues. The Nanosilver Linings hypothetical case was delivered through the format of the 3-hour workshop Ethics when Biocomplexity meets Human Complexity, providing an immersive, holistic ethics learning experience for STEM graduate students. Through their participation in the Nanosilver Linings case and Ethics when Biocomplexity meets Human Complexity workshop, four cohorts of science and engineering doctoral students reported the achievement of specific learning objectives pertaining to a range of macroethics concepts and professional practices, including stakeholder perspectives, communication, human values, and ethical frameworks. Automated text analysis of workshop transcripts revealed differences in sentiment and in ethical framework (consequentialism/deontology) preference between societal stakeholder roles. These resources have been recognized as ethics education exemplars by the U.S. National Academy of Engineering .

  5. Automated sample preparation for monitoring groundwater pollution by carbamate insecticides and their transformation products.

    PubMed

    Chiron, S; Valverde, A; Fernandez-Alba, A; Barceló, D

    1995-01-01

    We investigated automated on-line solid-phase extraction (SPE) followed by liquid chromatographic (LC) techniques for monitoring carbamates and their transformation products. Analytical determinations were performed by LC with UV or postcolumn fluorescence detection (U.S. Environmental Protection Agency Method 531.1 for carbamate insecticides) after preconcentration with on-line SPE using C18 Empore extraction disks. On-line SPE/LC/thermospray mass spectrometry with time-scheduled selected-ion monitoring was used as confirmatory method. The method was used to determine pesticide traces in well waters of a typical aquifer in the Almeria area (Andalucia, south of Spain) from March 1993 to February 1994. The major pollutants, found in highest amounts, were carbofuran, methiocarb, and methomyl, at levels of 0.32, 0.3, and 0.8 micrograms/L, respectively. According to results of seasonal variation studies, pollution by carbamate insecticides is sporadic and exceeds the limit of 0.5 micrograms/L for total pesticides allowed by the European Economic Community Drinking Water Directive only twice a year. 3-Hydroxycarbofuran and methiocarb sulfone also were detected, showing the importance of including the main toxic break-down products of carbamate insecticides in future monitoring programs.

  6. Formulation of a Production Strategy for a Software Product Line

    DTIC Science & Technology

    2009-08-01

    systems that compose the product line by defining those behaviors or aspects that are “in” and those behaviors or aspects that are “out” [Clements...Be standard. Seek out and use open standards. Participate in standards development so that you have maximum impact [ Hoyer 2006]. This strategy...Further, there needs to be a balance among the five forces so that no one force consumes a majority of the available resources. Feasibility can be judged

  7. Automated production of plant-based vaccines and pharmaceuticals.

    PubMed

    Wirz, Holger; Sauer-Budge, Alexis F; Briggs, John; Sharpe, Aaron; Shu, Sudong; Sharon, Andre

    2012-12-01

    A fully automated "factory" was developed that uses tobacco plants to produce large quantities of vaccines and other therapeutic biologics within weeks. This first-of-a-kind factory takes advantage of a plant viral vector technology to produce specific proteins within the leaves of rapidly growing plant biomass. The factory's custom-designed robotic machines plant seeds, nurture the growing plants, introduce a viral vector that directs the plant to produce a target protein, and harvest the biomass once the target protein has accumulated in the plants-all in compliance with Food and Drug Administration (FDA) guidelines (e.g., current Good Manufacturing Practices). The factory was designed to be time, cost, and space efficient. The plants are grown in custom multiplant trays. Robots ride up and down a track, servicing the plants and delivering the trays from the lighted, irrigated growth modules to each processing station as needed. Using preprogrammed robots and processing equipment eliminates the need for human contact, preventing potential contamination of the process and economizing the operation. To quickly produce large quantities of protein-based medicines, we transformed a laboratory-based biological process and scaled it into an industrial process. This enables quick, safe, and cost-effective vaccine production that would be required in case of a pandemic.

  8. Automated Measurement of Nerve Fiber Density Using Line Intensity Scan Analysis

    PubMed Central

    Sathyanesan, Aaron; Ogura, Tatsuya; Lin, Weihong

    2012-01-01

    Quantification of nerve fibers in peripheral and central nervous systems is important for the understanding of neuronal function, organization and pathological changes. However, current methods to quantify nerve fibers are resource-intensive and often provide an indirect measurement of nerve fiber density. Here, we describe an automated and efficient method for nerve fiber quantification, which we developed by making use of widely available software and analytical techniques, including Hessian-based feature extraction in NIH ImageJ and line intensity scan analysis. The combined use of these analytical tools through an automated routine enables reliable detection and quantification of nerve fibers from low magnification, non-uniformly labeled epifluorescence images. This allows for time-efficient determination of nerve density and also comparative analysis in large brain structures, such as hippocampus or between various regions of neural circuitry. Using this method, we have obtained accurate measurements of cholinergic fiber density in hippocampus and a large area of cortex in mouse brain sections immunolabeled with an antibody against the vesicular acetylcholine transporter (VAChT). The density values are comparable among animals tested, showing a high degree of reproducibility. Because our method can be performed at relatively low cost and in large tissue sections where nerve fibers can be labeled by various antibodies or visualized by expression of reporter proteins, such as green fluorescent protein in transgenic mice, we expect our method to be broadly useful in both research and clinical investigation. To our knowledge, this is the first method to reliably quantify nerve fibers through a rapid and automated protocol. PMID:22613744

  9. Production and quality assurance automation in the Goddard Space Flight Center Flight Dynamics Facility

    NASA Technical Reports Server (NTRS)

    Chapman, K. B.; Cox, C. M.; Thomas, C. W.; Cuevas, O. O.; Beckman, R. M.

    1994-01-01

    The Flight Dynamics Facility (FDF) at the NASA Goddard Space Flight Center (GSFC) generates numerous products for NASA-supported spacecraft, including the Tracking and Data Relay Satellites (TDRS's), the Hubble Space Telescope (HST), the Extreme Ultraviolet Explorer (EUVE), and the space shuttle. These products include orbit determination data, acquisition data, event scheduling data, and attitude data. In most cases, product generation involves repetitive execution of many programs. The increasing number of missions supported by the FDF has necessitated the use of automated systems to schedule, execute, and quality assure these products. This automation allows the delivery of accurate products in a timely and cost-efficient manner. To be effective, these systems must automate as many repetitive operations as possible and must be flexible enough to meet changing support requirements. The FDF Orbit Determination Task (ODT) has implemented several systems that automate product generation and quality assurance (QA). These systems include the Orbit Production Automation System (OPAS), the New Enhanced Operations Log (NEOLOG), and the Quality Assurance Automation Software (QA Tool). Implementation of these systems has resulted in a significant reduction in required manpower, elimination of shift work and most weekend support, and improved support quality, while incurring minimal development cost. This paper will present an overview of the concepts used and experiences gained from the implementation of these automation systems.

  10. Advances in Automated QA/QC for TRISO Fuel Particle Production

    SciTech Connect

    Hockey, Ronald L.; Bond, Leonard J.; Batishko, Charles R.; Gray, Joseph N.; Saurwein, John J.; Lowden, Richard A.

    2004-06-30

    Fuel in most Generation IV reactor designs typically encompasses billions of the TRISO particles. Present day QA/QC methods, done manually and in many cases destructively, cannot economically test a statistically significant fraction of the large number of the individual fuel particles required. Fully automated inspection technologies are essential to economical TRISO fuel particle production. A combination of in-line nondestructive (NDE) measurements employing electromagnetic induction and digital optical imaging analysis is currently under investigation and preliminary data indicate the potential for meeting the demands of this application. To calibrate high-speed NDE methods, surrogate fuel particle samples are being coated with layers containing a wide array of defect types found to degrade fuel performance and these are being characterized via high-resolution CT and digital radiographic images.

  11. Towards automated production and drug sensitivity testing using scaffold-free spherical tumor microtissues.

    PubMed

    Drewitz, Maren; Helbling, Marianne; Fried, Nicole; Bieri, Manuela; Moritz, Wolfgang; Lichtenberg, Jan; Kelm, Jens M

    2011-12-01

    Although the relevance of three-dimensional (3-D) culture has been recognized for years and exploited at an academic level, its translation to industrial applications has been slow. The development of reliable high-throughput technologies is clearly a prerequisite for the industrial implementation of 3-D models. In this study the robustness of spherical microtissue production and drug testing in a 96-well hanging-drop multiwell plate format was assessed on a standard 96-well channel robotic platform. Microtissue models derived from six different cell lines were produced and characterized according to their growth profile and morphology displaying high-density tissue-like reformation and growth over at least 15 days. The colon cancer cell line HCT116 was chosen as a model to assess microtissue-based assay reproducibility. Within three individual production batches the size variations of the produced microtissues were below 5%. Reliability of the microtissue-based assay was tested using two reference compounds, staurosporine and chlorambucil. In four independent drug testings the calculated IC(50) values were benchmarked against 2-D multiwell testings displaying similar consistency. The technology presented here for the automated production of a variety of microtissues for efficacy testing in a standard 96-well format will aid the implementation of more organotypic models at an early time point in the drug discovery process.

  12. On-line tritium production monitor

    DOEpatents

    Mihalczo, J.T.

    1993-11-23

    A scintillation optical fiber system for the on-line monitoring of nuclear reactions in an event-by-event manner is described. In the measurement of tritium production one or more optical fibers are coated with enriched {sup 6}Li and connected to standard scintillation counter circuitry. A neutron generated {sup 6}Li(n)T reaction occurs in the coated surface of {sup 6}Li-coated fiber to produce energetic alpha and triton particles one of which enters the optical fiber and scintillates light through the fiber to the counting circuit. The coated optical fibers can be provided with position sensitivity by placing a mirror at the free end of the fibers or by using pulse counting circuits at both ends of the fibers. 5 figures.

  13. On-line tritium production monitor

    DOEpatents

    Mihalczo, John T.

    1993-01-01

    A scintillation optical fiber system for the on-line monitoring of nuclear reactions in an event-by-event manner is described. In the measurement of tritium production one or more optical fibers are coated with enriched .sup.6 Li and connected to standard scintillation counter circuitry. A neutron generated .sup.6 Li(n )T reaction occurs in the coated surface of .sup.6 Li-coated fiber to produce energetic alpha and triton particles one of which enters the optical fiber and scintillates light through the fiber to the counting circuit. The coated optical fibers can be provided with position sensitivity by placing a mirror at the free end of the fibers or by using pulse counting circuits at both ends of the fibers.

  14. Process development for automated solar cell and module production. Task 4: Automated array assembly

    NASA Technical Reports Server (NTRS)

    Hagerty, J. J.

    1981-01-01

    The cell preparation station was installed in its new enclosure. Operation verification tests were performed. The detailed layout drawings of the automated lamination station were produced and construction began. All major and most minor components were delivered by vendors. The station framework was built and assembly of components begun.

  15. Human communication needs and organizational productivity: the potential impact of office automation.

    PubMed

    Culnan, M J; Bair, J H

    1983-05-01

    Much of what white collar workers do in offices is communication-related. White collar workers make up the majority of the labor force in the United States today and the majority of current labor costs. Because office automation represents more productive structured techniques for handling both written and oral communication, office automation therefore offers the potential to make organizations more productive by improving organizational communication. This article: (1) defines communication, (2) identifies the potential benefits to be realized from implementing office automation, and (3) offers caveats related to the implementation of office automation systems. Realization of the benefits of office automation depends upon the degree to which new modes of communication may be successfully substituted for traditional modes.

  16. “Development of an Automated On-line Electrochemical Chlorite Ion Sensor”

    PubMed Central

    Myers, John N.; Steinecker, William H.; Sandlin, Zechariah D.; Cox, James A.; Gordon, Gilbert; Pacey, Gilbert E.

    2012-01-01

    A sensor system for the automatic, in-line, determination of chlorite ion is reported. Electroanalytical measurements were performed in electrolyte-free liquids by using an electrochemical probe (EC), which enables in-line detection in high-resistance media such as disinfected water. Cyclic voltammetry scan rate studies suggest that the current arising from the oxidation of chlorite ion at an EC probe is mass-transfer limited. By coupling FIA with an EC probe amperometric cell, automated analysis was achieved. This sensor is intended to fulfill the daily monitoring requirements of the EPA DBP regulations for chlorite ion. Detection limits of 0.02-0.13 mg/L were attained, which is about one order of magnitude below the MRDL. The sensor showed no faradaic signal for perchlorate, chlorate, or nitrate. The lifetime and stability of the sensor were investigated by measuring calibration curves over time under constant-flow conditions. Detection limits of <0.1 mg/L were repeatedly achieved over a period of three weeks. PMID:22608440

  17. Development of an automated on-line electrochemical chlorite ion sensor.

    PubMed

    Myers, John N; Steinecker, William H; Sandlin, Zechariah D; Cox, James A; Gordon, Gilbert; Pacey, Gilbert E

    2012-05-30

    A sensor system for the automatic, in-line, determination of chlorite ion is reported. Electroanalytical measurements were performed in electrolyte-free liquids by using an electrochemical probe (EC), which enables in-line detection in high-resistance media such as disinfected water. Cyclic voltammetry scan rate studies suggest that the current arising from the oxidation of chlorite ion at an EC probe is mass-transfer limited. By coupling FIA with an EC probe amperometric cell, automated analysis was achieved. This sensor is intended to fulfill the daily monitoring requirements of the EPA DBP regulations for chlorite ion. Detection limits of 0.02-0.13 mg/L were attained, which is about one order of magnitude below the MRDL. The sensor showed no faradaic signal for perchlorate, chlorate, or nitrate. The lifetime and stability of the sensor were investigated by measuring calibration curves over time under constant-flow conditions. Detection limits of <0.1 mg/L were repeatedly achieved over a period of three weeks.

  18. Software Product Lines: Reuse That Makes Business Sense

    DTIC Science & Technology

    2007-03-01

    Product Line Practice • Software Architecture Technology • Predictable Assembly from Certifiable Components Dynamic Systems • Integration of Software... Technology • Predictable Assembly from Certifiable Components Dynamic Systems • Integration of Software-Intensive Systems • Performance-Critical...Line Systems Program The Product Line Systems (PLS) Program • creates, matures, applies, and transitions technology and practices • to effect widespread

  19. Production Line for Dendritic-Web Solar Cells

    NASA Technical Reports Server (NTRS)

    Page, D. J.

    1985-01-01

    Direct inclusion of web-growth furnaces in production line expected to result in lower costs than current production processes using silicon wafers sliced from Czochralski boules. Silicon-web input capacity of line is 0.5 m2/min, which corresponds to total peak-power output of about 25 MW for 1 year of production. Line employs about 18 production people per shift and requires about 3,650 square feet of floorspace.

  20. CERES AuTomAted job Loading SYSTem (CATALYST): An automated workflow manager for satellite data production

    NASA Astrophysics Data System (ADS)

    Gleason, J. L.; Hillyer, T. N.; Wilkins, J.

    2012-12-01

    The CERES Science Team integrates data from 5 CERES instruments onboard the Terra, Aqua and NPP missions. The processing chain fuses CERES observations with data from 19 other unique sources. The addition of CERES Flight Model 5 (FM5) onboard NPP, coupled with ground processing system upgrades further emphasizes the need for an automated job-submission utility to manage multiple processing streams concurrently. The operator-driven, legacy-processing approach relied on manually staging data from magnetic tape to limited spinning disk attached to a shared memory architecture system. The migration of CERES production code to a distributed, cluster computing environment with approximately one petabyte of spinning disk containing all precursor input data products facilitates the development of a CERES-specific, automated workflow manager. In the cluster environment, I/O is the primary system resource in contention across jobs. Therefore, system load can be maximized with a throttling workload manager. This poster discusses a Java and Perl implementation of an automated job management tool tailored for CERES processing.

  1. Line Pilots' Attitudes about and Experience with Flight Deck Automation: Results of an International Survey and Proposed Guidelines

    NASA Technical Reports Server (NTRS)

    Rudisill, Marianne

    1995-01-01

    A survey of line pilots' attitudes about flight deck automation was conducted by the Royal Air Force Institute of Aviation Medicine (RAF IAM, Farnborough, UK) under the sponsorship of the United Kingdom s Civil Aviation Authority and in cooperation with IATA (the International Air Transport Association). Survey freehand comments given by pilots operating 13 types of commercial transports across five manufacturers (Airbus, Boeing, British Aerospace, Lockheed, and McDonnell-Douglas) and 57 air carriers/organizations were analyzed by NASA. These data provide a "lessons learned" knowledge base which may be used for the definition of guidelines for flight deck automation and its associated crew interface within the High Speed Research Program. The aircraft chosen for analysis represented a progression of levels of automation sophistication and complexity, from "Basic" types (e.g., B727, DC9), through "Transition" types (e.g., A300, Concorde), to two levels of glass cockpits (e.g., Glass 1: e.g., A310; Glass 2: e.g., B747-400). This paper reports the results of analyses of comments from pilots flying commercial transport types having the highest level of automation sophistication (B757/B767, B747-400, and A320). Comments were decomposed into five categories relating to: (1) general observations with regard to flight deck automation; comments concerning the (2) design and (3) crew understanding of automation and the crew interface; (4) crew operations with automation; and (5) personal factors affecting crew/automation interaction. The goal of these analyses is to contribute to the definition of guidelines which may be used during design of future aircraft flight decks.

  2. Process development for automated solar cell and module production. Task 4: Automated array assembly

    NASA Technical Reports Server (NTRS)

    Hagerty, J. J.

    1981-01-01

    The Unimate robot was programmed for the final 35 cell pattern to be used in the fabrication of the deliverable modules. Mechanical construction of the Automated Lamination Station and Final Assembly Station were completed on schedule. All final wiring and interconnect cables were also completed and the first operational testing began. The final controlling program was written. A local fabricator was contracted to produce the glass reinforced concrete panels to be used for testing and deliverables. A video tape showing all three stations in operation was produced.

  3. Microsoft Business Solutions-Axapta as a basis for automated monitoring of high technology products competitiveness

    NASA Astrophysics Data System (ADS)

    Tashchiyan, G. O.; Sushko, A. V.; Grichin, S. V.

    2015-09-01

    One of the conditions of normal performance of the Russian economy is the problem of high technology products competitiveness. Different tools of these products estimation are used nowadays, one of them is automated monitoring of the high technology products in mechanical engineering. This system is developed on the basis of “Innovator" software integrated in Microsoft Business Solutions-Axapta.

  4. Harnessing natural product assembly lines: structure, promiscuity, and engineering

    PubMed Central

    Ladner, Christopher C; Williams, Gavin J

    2015-01-01

    Many therapeutically relevant natural products are biosynthesized by the action of giant mega-enzyme assembly lines. By leveraging the specificity, promiscuity, and modularity of assembly lines, a variety of strategies have been developed that enable the biosynthesis of modified natural products. This review briefly summarizes recent structural advances related to natural product assembly lines, discusses chemical approaches to probing assembly line structures in the absence of traditional biophysical data, and surveys efforts that harness the inherent or engineered promiscuity of assembly lines for the synthesis of non-natural polyketides and nonribosomal peptide analogues. PMID:26527577

  5. A sensor skid for precise 3D modeling of production lines

    NASA Astrophysics Data System (ADS)

    Elseberg, J.; Borrmann, D.; Schauer, J.; Nüchter, A.; Koriath, D.; Rautenberg, U.

    2014-05-01

    Motivated by the increasing need of rapid characterization of environments in 3D, we designed and built a sensor skid that automates the work of an operator of terrestrial laser scanners. The system combines terrestrial laser scanning with kinematic laser scanning and uses a novel semi-rigid SLAMmethod. It enables us to digitize factory environments without the need to stop production. The acquired 3D point clouds are precise and suitable to detect objects that collide with items moved along the production line.

  6. DoD Product Line Practice Workshop Report

    DTIC Science & Technology

    1998-05-01

    SEI Overview Presentations 7 2.1 Introduction 7 2.2 Essentials of Successful Product Line Practice, Linda M. Northrop - SEI 7 2.2.1 Motivation 7...framework for product line practice. The framework identifies the essential elements and practices that an organization should master for successful...TTWAA) Brian Bulat , Joint National Test Facility/Lockheed Martin Paul Clements, Product Line Systems Program, Software Engineering Institute Sholom

  7. Production system chunking in SOAR: Case studies in automated learning

    NASA Technical Reports Server (NTRS)

    Allen, Robert

    1989-01-01

    A preliminary study of SOAR, a general intelligent architecture for automated problem solving and learning, is presented. The underlying principles of universal subgoaling and chunking were applied to a simple, yet representative, problem in artificial intelligence. A number of problem space representations were examined and compared. It is concluded that learning is an inherent and beneficial aspect of problem solving. Additional studies are suggested in domains relevant to mission planning and to SOAR itself.

  8. Automation and integration of multiplexed on-line sample preparation with capillary electrophoresis for DNA sequencing

    SciTech Connect

    Tan, H.

    1999-03-31

    The purpose of this research is to develop a multiplexed sample processing system in conjunction with multiplexed capillary electrophoresis for high-throughput DNA sequencing. The concept from DNA template to called bases was first demonstrated with a manually operated single capillary system. Later, an automated microfluidic system with 8 channels based on the same principle was successfully constructed. The instrument automatically processes 8 templates through reaction, purification, denaturation, pre-concentration, injection, separation and detection in a parallel fashion. A multiplexed freeze/thaw switching principle and a distribution network were implemented to manage flow direction and sample transportation. Dye-labeled terminator cycle-sequencing reactions are performed in an 8-capillary array in a hot air thermal cycler. Subsequently, the sequencing ladders are directly loaded into a corresponding size-exclusion chromatographic column operated at {approximately} 60 C for purification. On-line denaturation and stacking injection for capillary electrophoresis is simultaneously accomplished at a cross assembly set at {approximately} 70 C. Not only the separation capillary array but also the reaction capillary array and purification columns can be regenerated after every run. DNA sequencing data from this system allow base calling up to 460 bases with accuracy of 98%.

  9. Automated paleomagnetic and rock magnetic data acquisition with an in-line horizontal "2G" system

    NASA Astrophysics Data System (ADS)

    Mullender, Tom A. T.; Frederichs, Thomas; Hilgenfeldt, Christian; de Groot, Lennart V.; Fabian, Karl; Dekkers, Mark J.

    2016-09-01

    Today's paleomagnetic and magnetic proxy studies involve processing of large sample collections while simultaneously demanding high quality data and high reproducibility. Here we describe a fully automated interface based on a commercial horizontal pass-through "2G" DC-SQUID magnetometer. This system is operational at the universities of Bremen (Germany) and Utrecht (Netherlands) since 1998 and 2006, respectively, while a system is currently being built at NGU Trondheim (Norway). The magnetometers are equipped with "in-line" alternating field (AF) demagnetization, a direct-current bias field coil along the coaxial AF demagnetization coil for the acquisition of anhysteretic remanent magnetization (ARM) and a long pulse-field coil for the acquisition of isothermal remanent magnetization (IRM). Samples are contained in dedicated low magnetization perspex holders that are manipulated by a pneumatic pick-and-place-unit. Upon desire samples can be measured in several positions considerably enhancing data quality in particular for magnetically weak samples. In the Bremen system, the peak of the IRM pulse fields is actively measured which reduces the discrepancy between the set field and the field that is actually applied. Techniques for quantifying and removing gyroremanent overprints and for measuring the viscosity of IRM further extend the range of applications of the system. Typically c. 300 paleomagnetic samples can be AF demagnetized per week (15 levels) in the three-position protocol. The versatility of the system is illustrated by several examples of paleomagnetic and rock magnetic data processing.

  10. Practical methods for automated reconstruction and characterization of particles in digital in-line holograms

    NASA Astrophysics Data System (ADS)

    Fugal, Jacob P.; Schulz, Timothy J.; Shaw, Raymond A.

    2009-07-01

    Hologram reconstruction algorithms often undersample the phase in propagation kernels for typical parameters of holographic optical setups. Given in this paper is an algorithm that addresses this phase undersampling in reconstructing digital in-line holograms of particles for these typical parameters. This algorithm has a lateral sample spacing constant in reconstruction distance, has a diffraction limited resolution, and can be implemented with computational speeds comparable to the fastest of other reconstruction algorithms. This algorithm is shown to be accurate by testing with analytical solutions to the Huygens-Fresnel propagation integral. A low-pass filter can be applied to enforce a uniform minimum particle size detection limit throughout a sample volume, allowing this method to be useful in measuring particle size distributions and number densities. Tens of thousands of holograms of cloud ice particles are digitally reconstructed using the algorithm discussed. Positions of ice particles in the size range of 20 µm-1.5 mm are obtained using an algorithm that accurately finds the position of large and small particles along the optical axis. The digital reconstruction and particle characterization algorithms are implemented in an automated fashion with no user intervention on a computer cluster. Strategies for efficient algorithm implementation on a computer cluster are discussed.

  11. a Novel Method for Automation of 3d Hydro Break Line Generation from LIDAR Data Using Matlab

    NASA Astrophysics Data System (ADS)

    Toscano, G. J.; Gopalam, U.; Devarajan, V.

    2013-08-01

    Water body detection is necessary to generate hydro break lines, which are in turn useful in creating deliverables such as TINs, contours, DEMs from LiDAR data. Hydro flattening follows the detection and delineation of water bodies (lakes, rivers, ponds, reservoirs, streams etc.) with hydro break lines. Manual hydro break line generation is time consuming and expensive. Accuracy and processing time depend on the number of vertices marked for delineation of break lines. Automation with minimal human intervention is desired for this operation. This paper proposes using a novel histogram analysis of LiDAR elevation data and LiDAR intensity data to automatically detect water bodies. Detection of water bodies using elevation information was verified by checking against LiDAR intensity data since the spectral reflectance of water bodies is very small compared with that of land and vegetation in near infra-red wavelength range. Detection of water bodies using LiDAR intensity data was also verified by checking against LiDAR elevation data. False detections were removed using morphological operations and 3D break lines were generated. Finally, a comparison of automatically generated break lines with their semi-automated/manual counterparts was performed to assess the accuracy of the proposed method and the results were discussed.

  12. From product line to disease management--easing the transition.

    PubMed

    Stanfill, P

    1997-01-01

    Most facilities have captured the essence of product-line management, but what is the next step? The traditional reasons for product-line management are still more than valid, but forward-thinking organizations are moving to a disease-management focus.

  13. Technology Management within Product Lines in High Technology Markets

    ERIC Educational Resources Information Center

    Sarangee, Kumar R.

    2009-01-01

    Understanding the nuances of product line management has been of great interest to business scholars and practitioners. This assumes greater significance for firms conducting business in technologically dynamic industries, where they face certain challenges regarding the management of multiple, overlapping technologies within their product lines.…

  14. The Development of an On-Line, Partially Automated Discharge Summary and Core Clinical Data-Base in an Existing Hospital Information System

    PubMed Central

    Roberts, Mark S.; Zibrak, Joseph D.; Siders, Alice; Zullo, Nan; Peterson, Mark

    1989-01-01

    We describe the development of a hospital-wide computer system that produces on-line, partially automated discharge summaries, assists nursing staff with discharge functions, and stores a core clinical database on all patients. The system was created using only tools and functions contained within the existing order-entry/results reporting hospital information system. Data enters the discharge database in three ways: direct transfer from the information system, on line selection by physicians and nurses of specific data already contained in the system (eg. lab and radiology results), and by typed input of varying amounts of text (eg. chief complaint, hospital course). If completed the night prior to discharge, the system produces several products for residents and nurses, included typed prescriptions, the printed discharge summary, nursing referral or patient care forms, and simple discharge planning information for the patient. During the course of a 9 week pilot program, 428 summaries were completed on the system, 420 of which met JCHAO criteria.

  15. Implementation of an Automated High-Throughput Plasmid DNA Production Pipeline.

    PubMed

    Billeci, Karen; Suh, Christopher; Di Ioia, Tina; Singh, Lovejit; Abraham, Ryan; Baldwin, Anne; Monteclaro, Stephen

    2016-12-01

    Biologics sample management facilities are often responsible for a diversity of large-molecule reagent types, such as DNA, RNAi, and protein libraries. Historically, the management of large molecules was dispersed into multiple laboratories. As methodologies to support pathway discovery, antibody discovery, and protein production have become high throughput, the implementation of automation and centralized inventory management tools has become important. To this end, to improve sample tracking, throughput, and accuracy, we have implemented a module-based automation system integrated into inventory management software using multiple platforms (Hamilton, Hudson, Dynamic Devices, and Brooks). Here we describe the implementation of these systems with a focus on high-throughput plasmid DNA production management.

  16. A Physics-based Automated Technique for the Detection of Field Line Resonance Frequency in Ground Magnetometer Data

    NASA Astrophysics Data System (ADS)

    Boudouridis, A.; Zesta, E.; Moldwin, M.

    2015-12-01

    The accurate determination of the Field Line Resonance (FLR) frequency of a resonating geomagnetic field line is necessary for the remote monitoring of the plasmaspheric mass density during geomagnetic storms and quiet times alike. Under certain assumptions the plasmaspheric mass density at the equator is inversely proportional to the square of the FLR frequency. The most common techniques to determine the FLR frequency from ground magnetometer measurements are the amplitude ratio and phase difference techniques, both based on geomagnetic field measurements at two latitudinally separated ground stations. Previously developed automated techniques have used statistical methods to pinpoint the FLR frequency using the amplitude ratio and phase difference calculations. We now introduce a physics-based automated technique that can reproduce the resonant wave characteristics from the two ground station data, and from those determine the FLR frequency. The advantage of the new technique, besides moving away from ambiguous statistical manipulations of the ground data, is the estimation of physically determined errors of the FLR frequency, which can yield physically determined errors of the equatorial plasmaspheric mass density. We present preliminary results of the new technique calculations, and test it using data from the new Inner-Magnetospheric Array for Geospace Science (iMAGS) ground magnetometer chain along the coast of Chile and the east coast of the United States. We compare the results with the results of previously published statistical automated techniques.

  17. Reliability and maintainability analysis of bread production line.

    PubMed

    Tsarouhas, Panagiotis H; Arvanitoyannis, Ioannis S

    2010-04-01

    The statistical analysis of the bread production line of the failure and repair data at machine and line levels was displayed. The experiment covers a period of twenty-five months. The best fit of the failure data between the common theoretical distributions was found and its parameters were computed. The reliability and hazard rate modes for all machines and the entire production line were calculated as well. The models could prove to be a useful tool to assess the current conditions, and to predict the reliability for upgrading the maintenance policy of the production line. It was pointed out that (a) the availability of the bread production line is 90.74% and went down to 86.76% because the equipment's failures cause an additional production gap in the line, (b) the 53.5% of all failures occurred at the bread machine, cooling tower machine, and volumetric-divider machine, and (c) the machines of the bread production line that displayed increasing hazard rate functions were identified. This analysis will be very useful in terms of identifying the occurring and latent problems in manufacturing process of bread and improve it.

  18. Automated Finite State Workflow for Distributed Data Production

    NASA Astrophysics Data System (ADS)

    Hajdu, L.; Didenko, L.; Lauret, J.; Amol, J.; Betts, W.; Jang, H. J.; Noh, S. Y.

    2016-10-01

    In statistically hungry science domains, data deluges can be both a blessing and a curse. They allow the narrowing of statistical errors from known measurements, and open the door to new scientific opportunities as research programs mature. They are also a testament to the efficiency of experimental operations. However, growing data samples may need to be processed with little or no opportunity for huge increases in computing capacity. A standard strategy has thus been to share resources across multiple experiments at a given facility. Another has been to use middleware that “glues” resources across the world so they are able to locally run the experimental software stack (either natively or virtually). We describe a framework STAR has successfully used to reconstruct a ~400 TB dataset consisting of over 100,000 jobs submitted to a remote site in Korea from STAR's Tier 0 facility at the Brookhaven National Laboratory. The framework automates the full workflow, taking raw data files from tape and writing Physics-ready output back to tape without operator or remote site intervention. Through hardening we have demonstrated 97(±2)% efficiency, over a period of 7 months of operation. The high efficiency is attributed to finite state checking with retries to encourage resilience in the system over capricious and fallible infrastructure.

  19. An environmental friendly recovery production line of waste toner cartridges.

    PubMed

    Ruan, Jujun; Li, Jia; Xu, Zhenming

    2011-01-30

    Quantity of waste toner cartridges has been generated following the increasing demand for printer and duplicator. Waste toner cartridge contains abundant valuable metals, plastics as well as toxic residual toner. Therefore, the recovery of waste toner cartridges is a meaningful subject, not only from waste treatment but also from environment protection. This study proposed a mechanical production line for recovering waste toner cartridges. The recovery process involved shearing process, magnetic separation, and eddy current separation. The recovery rates of steel (magnet), toner, aluminum, and plastic were 98.4%, 95%, 97.5%, and 98.8%, respectively. The results of the comparison between the production line and full manual dismantling indicated that the production line succeed in recovering waste toner cartridges. In addition, the proposed production line is an efficient and environmental friendly way for recovering waste toner cartridges.

  20. Implementation of automated macro after develop inspection in a production lithography process

    NASA Astrophysics Data System (ADS)

    Yanof, Arnold W.; Plachecki, Vincent E.; Fischer, Frank W.; Cusacovich, Marcelo; Nelson, Chris; Merrill, Mark A.

    2000-06-01

    impossibility of accurate classification and recording of defect types, locations, and layer of occurrence. In this paper, we discuss a pilot implementation of an automated macro inspection system at Motorola, Inc., which has enabled the early detection and containment of significant photolithography defects. We show a variety of different types of defects that have been effectively detected and identified by this system during production usage. We introduce a methodology for determining the automated tool's ability to discriminate between the defect signal and process noise. We indicate the potential for defect database analysis, and identification of maverick product. Based upon the pilot experience, we discuss the parameters of a cost/benefit analysis of full implementation. The costs involve tool cost, additional wafer dispositions, and the engineering costs of recipe management. The most tangible measurable benefit is the saved revenue of scrapped wafers. An analysis of risk also shows a major reduction due to improved detection, as well as reduced occurrence because of better containment. This reduction of risk extends both to the customer -- in terms of field failures, OTD, maverick product -- as well as to the production facility -- in terms of major scrap incidents, forced inking at probe, redo, and containment.

  1. Using a business practice model to control product line costs.

    PubMed

    Farr, Ronald J; Senn, Girard F; Whitten, Catherine M

    2006-08-01

    Faced with a downward turn in its total joint replacement product line, Avera McKennan Hospital was able to avert further decline and save dollar 500,000 annually by: Reviewing and analyzing the product line's past performance. Developing a business model to govern its new implant supply process. Obtaining physician buy-in. Ensuring vendor compliance with its new contracts. Developing a role as business partner with its orthopedic surgeons.

  2. Product line management: its meaning and future promise.

    PubMed

    Salter, V

    1986-05-01

    The concept of product line management has recently drawn much attention in the health care field. The impetus has come from both marketing and accounting professionals as they have sought to find solutions to identified problems. Examined here are the roots of product line management, the reasons for the growth in the application of the concept in health care, and whether it promises to solve the problems faced by health care organizations in the current highly competitive environment.

  3. Automated Protein Biomarker Analysis: on-line extraction of clinical samples by Molecularly Imprinted Polymers

    NASA Astrophysics Data System (ADS)

    Rossetti, Cecilia; Świtnicka-Plak, Magdalena A.; Grønhaug Halvorsen, Trine; Cormack, Peter A. G.; Sellergren, Börje; Reubsaet, Léon

    2017-03-01

    Robust biomarker quantification is essential for the accurate diagnosis of diseases and is of great value in cancer management. In this paper, an innovative diagnostic platform is presented which provides automated molecularly imprinted solid-phase extraction (MISPE) followed by liquid chromatography-mass spectrometry (LC-MS) for biomarker determination using ProGastrin Releasing Peptide (ProGRP), a highly sensitive biomarker for Small Cell Lung Cancer, as a model. Molecularly imprinted polymer microspheres were synthesized by precipitation polymerization and analytical optimization of the most promising material led to the development of an automated quantification method for ProGRP. The method enabled analysis of patient serum samples with elevated ProGRP levels. Particularly low sample volumes were permitted using the automated extraction within a method which was time-efficient, thereby demonstrating the potential of such a strategy in a clinical setting.

  4. Automated Protein Biomarker Analysis: on-line extraction of clinical samples by Molecularly Imprinted Polymers

    PubMed Central

    Rossetti, Cecilia; Świtnicka-Plak, Magdalena A.; Grønhaug Halvorsen, Trine; Cormack, Peter A.G.; Sellergren, Börje; Reubsaet, Léon

    2017-01-01

    Robust biomarker quantification is essential for the accurate diagnosis of diseases and is of great value in cancer management. In this paper, an innovative diagnostic platform is presented which provides automated molecularly imprinted solid-phase extraction (MISPE) followed by liquid chromatography-mass spectrometry (LC-MS) for biomarker determination using ProGastrin Releasing Peptide (ProGRP), a highly sensitive biomarker for Small Cell Lung Cancer, as a model. Molecularly imprinted polymer microspheres were synthesized by precipitation polymerization and analytical optimization of the most promising material led to the development of an automated quantification method for ProGRP. The method enabled analysis of patient serum samples with elevated ProGRP levels. Particularly low sample volumes were permitted using the automated extraction within a method which was time-efficient, thereby demonstrating the potential of such a strategy in a clinical setting. PMID:28303910

  5. Automated Production of High Rep Rate Foam Targets

    NASA Astrophysics Data System (ADS)

    Hall, F.; Spindloe, C.; Haddock, D.; Tolley, M.; Nazarov, W.

    2016-04-01

    Manufacturing low density targets in the numbers needed for high rep rate experiments is highly challenging. This report summarises advances from manual production to semiautomated and the improvements that follow both in terms of production time and target uniformity. The production process is described and shown to be improved by the integration of an xyz robot with dispensing capabilities. Results are obtained from manual and semiautomated production runs and compared. The variance in the foam thickness is reduced significantly which should decrease experimental variation due to target parameters and could allow for whole batches to be characterised by the measurement of a few samples. The work applies to both foil backed and free standing foam targets.

  6. Automation and quality assurance of the production cycle

    NASA Astrophysics Data System (ADS)

    Hajdu, L.; Didenko, L.; Lauret, J.

    2010-04-01

    Processing datasets on the order of tens of terabytes is an onerous task, faced by production coordinators everywhere. Users solicit data productions and, especially for simulation data, the vast amount of parameters (and sometime incomplete requests) point at the need for a tracking, control and archiving all requests made so a coordinated handling could be made by the production team. With the advent of grid computing the parallel processing power has increased but traceability has also become increasing problematic due to the heterogeneous nature of Grids. Any one of a number of components may fail invalidating the job or execution flow in various stages of completion and re-submission of a few of the multitude of jobs (keeping the entire dataset production consistency) a difficult and tedious process. From the definition of the workflow to its execution, there is a strong need for validation, tracking, monitoring and reporting of problems. To ease the process of requesting production workflow, STAR has implemented several components addressing the full workflow consistency. A Web based online submission request module, implemented using Drupal's Content Management System API, enforces ahead that all parameters are described in advance in a uniform fashion. Upon submission, all jobs are independently tracked and (sometime experiment-specific) discrepancies are detected and recorded providing detailed information on where/how/when the job failed. Aggregate information on success and failure are also provided in near real-time.

  7. Comparison of Manual Hematocrit Determinations vs Automated Methods for Hematopoietic Progenitor Cell Apheresis Products

    PubMed Central

    Avecilla, Scott T.; Marionneaux, Steven M.; Leiva, Tyler D.; Tonon, Jo-ann; Chan, Virgil T.; Moung, Christine; Meagher, Richard C.; Maslak, Peter

    2016-01-01

    BACKGROUND Allogeneic hematopoietic stem cell donor selection is based primarily on human leukocyte antigen degree of match and it often occurs without regard to the red blood cell (RBC) compatibility between donor and recipient. When major ABO-mismatched grafts are infused, it is imperative that an accurate determination of the incompatible RBC content is made to ensure that the product is safe for infusion. RBC content determination requires the hematocrit (HCT) parameter which can be obtained via manual (directly measured) or automated (calculated) methods. STUDY DESIGN AND METHODS Ninety-seven (97) apheresis hematopoietic progenitor grafts were assessed for HCT by manual testing and by 4 commercially available automated hematology analyzer instruments. A clinical model was developed to assess the frequency of unnecessary RBC reductions or alteration in standard infusion practice. RESULTS Statistically significant (p<0.001) differences were observed where the manual HCT value was markedly lower than automated HCT values. At stringent incompatible RBC threshold of 10 mL, the number of preventable RBC reduction procedures ranged from 18–69%. CONCLUSION Accurate determination of RBC content of hematopoietic progenitor grafts is essential for patient safety. Despite the rapidity and convenience offered by automated HCT methods, they significantly overestimate the incompatible RBC content of grafts which may trigger unnecessary RBC reduction procedures or split infusions. In products where automated HCT methods indicate excessive amounts of incompatible RBCs are present, we advise the performance of confirmatory testing with a manual HCT method to ensure that the automated HCT value is not a false positive. PMID:26395285

  8. Mechanisms and sites for astrophysical gamma ray line production

    NASA Technical Reports Server (NTRS)

    Ramaty, R.

    1978-01-01

    The production of gamma ray lines and estimates of line fluxes resulting from nuclear deexcitations, positron annihilation, and electron capture at various astrophysical sites are discussed. Supernova and nova explosions synthesize long-lived radioactive isotopes and eject them into space where they produce observable gamma ray lines by decaying into excited levels of daughter nuclei or by emitting positrons. Energetic charged particles in the interstellar medium, in supernova remants, in solar or stellar flares, and possibly in the vicinity of compact objects, produce gamma-ray lines by inelastic collisions which either excite nuclear levels or produce positrons and neutrons. Energetic particles can result from acceleration in time-varying magnetic fields (solar flares) or from gravitational accretion onto neutron stars and black holes. Electromagnetic processes in the strong magnetic fields of pulsars can produce positron-electron pairs, with line emission resulting from positron annihilation. Deexcitations of quantized states in strong magnetic fields can also produce lines.

  9. Automated segmentation and feature extraction of product inspection items

    NASA Astrophysics Data System (ADS)

    Talukder, Ashit; Casasent, David P.

    1997-03-01

    X-ray film and linescan images of pistachio nuts on conveyor trays for product inspection are considered. The final objective is the categorization of pistachios into good, blemished and infested nuts. A crucial step before classification is the separation of touching products and the extraction of features essential for classification. This paper addresses new detection and segmentation algorithms to isolate touching or overlapping items. These algorithms employ a new filter, a new watershed algorithm, and morphological processing to produce nutmeat-only images. Tests on a large database of x-ray film and real-time x-ray linescan images of around 2900 small, medium and large nuts showed excellent segmentation results. A new technique to detect and segment dark regions in nutmeat images is also presented and tested on approximately 300 x-ray film and approximately 300 real-time linescan x-ray images with 95-97 percent detection and correct segmentation. New algorithms are described that determine nutmeat fill ratio and locate splits in nutmeat. The techniques formulated in this paper are of general use in many different product inspection and computer vision problems.

  10. Automated two-step chromatography using an ÄKTA equipped with in-line dilution capability.

    PubMed

    Winters, Dwight; Chu, Carolyn; Walker, Kenneth

    2015-12-11

    There has been a great emphasis on developing higher-throughput protein purification techniques to screen potential human therapeutics faster and more efficiently. Not only is it desirable to have high-throughput purification for initial screens but it is also desirable to efficiently purify selected protein therapeutics in the amounts and purity required for definitive assays. Current automated tandem technologies involve size exclusion as a second step that often fails to generate the required purity, is not robust and can only be operated at a limited scale. We have modified an ÄKTA to enable in-line dilution, assuring that the automated loading of a second column from a first column elution can be modified to a pH and ionic strength which is suitable for binding to the second column. For example, Protein A can be employed as a first step followed by direct loading on to a cation exchange column by conditioning the Protein A elution using the in-line diluter. Using this method as described, up to six samples of 1L each can be purified through two columns without human intervention per day per machine, and the system produces good yields of purified protein over a wide range of loading levels (12-300mg). In addition, the system employs guanidine HCl regeneration, followed by a sodium hydroxide wash between purification runs, minimizing the possibility of carryover contamination. The system is described at the 5mL and the 10mL column sizes; however, it could readily be programed for 100mL columns to enable larger-scale purifications. Using this system to automate two-column purifications minimizes human intervention, increases efficiency and minimizes the risk of human error.

  11. Recombinant protein production from stable mammalian cell lines and pools.

    PubMed

    Hacker, David L; Balasubramanian, Sowmya

    2016-06-01

    We highlight recent developments for the production of recombinant proteins from suspension-adapted mammalian cell lines. We discuss the generation of stable cell lines using transposons and lentivirus vectors (non-targeted transgene integration) and site-specific recombinases (targeted transgene integration). Each of these methods results in the generation of cell lines with protein yields that are generally superior to those achievable through classical plasmid transfection that depends on the integration of the transfected DNA by non-homologous DNA end-joining. This is the main reason why these techniques can also be used for the generation of stable cell pools, heterogenous populations of recombinant cells generated by gene delivery and genetic selection without resorting to single cell cloning. This allows the time line from gene transfer to protein production to be reduced.

  12. Automated quantum mechanical total line shape fitting model for quantitative NMR-based profiling of human serum metabolites.

    PubMed

    Mihaleva, Velitchka V; Korhonen, Samuli-Petrus; van Duynhoven, John; Niemitz, Mathias; Vervoort, Jacques; Jacobs, Doris M

    2014-05-01

    An automated quantum mechanical total line shape (QMTLS) fitting model was implemented for quantitative nuclear magnetic resonance (NMR)-based profiling of 42 metabolites in ultrafiltrated human serum samples. Each metabolite was described by a set of chemical shifts, J-couplings, and line widths. These parameters were optimized for each metabolite in each sample by iteratively minimizing the difference between the calculated and the experimental spectrum. In total, 92.0 to 98.1 % of the signal intensities in the experimental spectrum could be explained by the calculated spectrum. The model was validated by comparison to signal integration of metabolites with isolated signals and by means of standard additions. Metabolites present at average concentration higher than 50 μM were quantified with average absolute relative error less than 10 % when using different initial parameters for the fitting procedure. Furthermore, the biological applicability of the QMTLS model was demonstrated on 287 samples from an intervention study in 37 human volunteers undergoing an exercise challenge. Our automated QMTLS model was able to cope with the large dynamic range of metabolite concentrations in serum and proved to be suitable for high-throughput analysis.

  13. Arctic production to put demands on line pipe

    SciTech Connect

    Not Available

    1985-05-01

    The launching of offshore production in the high Arctic will bring with it increased demand for the line pipe exhibiting good weldability and toughness characteristics in extremely low temperatures. West German steelmakers long have been recognized for supplying pipe and structural materials to the offshore market. Increased emphasis on arctic oil and gas exploration has seen the Germans increase research and development efforts on arctic grade steels, particularly line pipe. These R and D efforts are discussed.

  14. An automated two-phase system for hydrogel microbead production.

    PubMed

    Coutinho, Daniela F; Ahari, Amir F; Kachouie, Nezamoddin N; Gomes, Manuela E; Neves, Nuno M; Reis, Rui L; Khademhosseini, Ali

    2012-09-01

    Polymeric beads have been used for protection and delivery of bioactive materials, such as drugs and cells, for different biomedical applications. Here, we present a generic two-phase system for the production of polymeric microbeads of gellan gum or alginate, based on a combination of in situ polymerization and phase separation. Polymer droplets, dispensed using a syringe pump, formed polymeric microbeads while passing through a hydrophobic phase. These were then crosslinked, and thus stabilized, in a hydrophilic phase as they crossed through the hydrophobic-hydrophilic interface. The system can be adapted to different applications by replacing the bioactive material and the hydrophobic and/or the hydrophilic phases. The size of the microbeads was dependent on the system parameters, such as needle size and solution flow rate. The size and morphology of the microbeads produced by the proposed system were uniform, when parameters were kept constant. This system was successfully used for generating polymeric microbeads with encapsulated fluorescent beads, cell suspensions and cell aggregates proving its ability for generating bioactive carriers that can potentially be used for drug delivery and cell therapy.

  15. The Rapidform process for automated thermoplastic socket production.

    PubMed

    Davies, R M; Lawrence, R B; Routledge, P E; Knox, W

    1985-04-01

    This paper describes the genesis of the Rapidform process and its pioneering place in the new developments leading to complete control of the processes of manufacture of prostheses. The materials and geometric considerations involved in the development of a double deformation process under microprocessor control are described. Stages in the development of the system show the advance from the initial application to modular below-knee prostheses through extensions to special suspension systems (supracondylar and suprapatellar) to Syme's and above-knee sockets. The clinical and laboratory results are summarized along with an account of the current aspects of the project, ie advanced clinical trials, testing and analysis. Setting the scene historically for the other computer based modules in this high technology approach to prosthetics, Rapidform has proven to be swift, accurate and economical in its operation. Also, in common with the rest of the suite of equipment, this socket production facility, despite its flexibility and technical sophistication, requires no special services beyond standard single phase mains electricity supply.

  16. Simulation of a Production Facility with an Automated Transport System

    SciTech Connect

    ABRAMCZYK, GLENN

    2004-04-07

    A model was needed to assess material throughput and validate the conceptual design of a production facility, including equipment lists and layout. The initial desire was to use a commercially available discrete event simulation package. However, the available software was found to be too limited in capability. Database interface software was used to develop autonomous intelligent manufacturing workstations and material transporters. The initial Extend model used to assess material throughput and develop equipment lists for the preconceptual design effort was upgraded with software add-ons from Simulation Dynamics, Inc. (SDI). Use of the SDI database interface allowed the upgraded model to include: 1. a material mass balance at any level of detail required by the user, and 2. a transport system model that includes all transport system movements, time delays, and transfers between systems. This model will assist in evaluating transport system capacity, sensitive time delays in the system, and optimal operating strategies. An additional benefit of using the SDI database interface is dramatically improved run time performance. This allows significantly more runs to be completed to provide better statistics for overall plant performance. The model has all system and process parameters entered into sub-component accessible tables. All information for the manufactured items and process data is automatically generated and written to the database. The standard software is used for the movement of manufactured items between workstations, and for sequence and timing functions. Use of the database permits almost unlimited process control and data collection with an insignificant effect on run time.

  17. Verifying Architectural Design Rules of the Flight Software Product Line

    NASA Technical Reports Server (NTRS)

    Ganesan, Dharmalingam; Lindvall, Mikael; Ackermann, Chris; McComas, David; Bartholomew, Maureen

    2009-01-01

    This paper presents experiences of verifying architectural design rules of the NASA Core Flight Software (CFS) product line implementation. The goal of the verification is to check whether the implementation is consistent with the CFS architectural rules derived from the developer's guide. The results indicate that consistency checking helps a) identifying architecturally significant deviations that were eluded during code reviews, b) clarifying the design rules to the team, and c) assessing the overall implementation quality. Furthermore, it helps connecting business goals to architectural principles, and to the implementation. This paper is the first step in the definition of a method for analyzing and evaluating product line implementations from an architecture-centric perspective.

  18. Generation of cell lines for monoclonal antibody production.

    PubMed

    Alvin, Krista; Ye, Jianxin

    2014-01-01

    Monoclonal antibodies (mAbs) represent the largest group of therapeutic proteins with 30 products approved in the USA and hundreds of therapies currently undergoing clinical trials. The complex nature of mAbs makes their development as therapeutic agents constrained by numerous criteria such as quality, safety, regulation, and quantity. Identification of a clonal cell line expressing high levels of mAb with adequate quality attributes and generated in compliance with regulatory standards is a necessary step prior to a program moving to large-scale production for clinical material. This chapter outlines the stable transfection technology that generates clonal cell lines for commercial manufacturing processes.

  19. SAGA: A project to automate the management of software production systems

    NASA Technical Reports Server (NTRS)

    Campbell, R. H.; Badger, W.; Beckman, C. S.; Beshers, G.; Hammerslag, D.; Kimball, J.; Kirslis, P. A.; Render, H.; Richards, P.; Terwilliger, R.

    1984-01-01

    The project to automate the management of software production systems is described. The SAGA system is a software environment that is designed to support most of the software development activities that occur in a software lifecycle. The system can be configured to support specific software development applications using given programming languages, tools, and methodologies. Meta-tools are provided to ease configuration. Several major components of the SAGA system are completed to prototype form. The construction methods are described.

  20. Interdisciplinary development of manual and automated product usability assessments for older adults with dementia: lessons learned.

    PubMed

    Boger, Jennifer; Taati, Babak; Mihailidis, Alex

    2016-10-01

    The changes in cognitive abilities that accompany dementia can make it difficult to use everyday products that are required to complete activities of daily living. Products that are inherently more usable for people with dementia could facilitate independent activity completion, thus reducing the need for caregiver assistance. The objectives of this research were to: (1) gain an understanding of how water tap design impacted tap usability and (2) create an automated computerized tool that could assess tap usability. 27 older adults, who ranged from cognitively intact to advanced dementia, completed 1309 trials on five tap designs. Data were manually analyzed to investigate tap usability as well as used to develop an automated usability analysis tool. Researchers collaborated to modify existing techniques and to create novel ones to accomplish both goals. This paper presents lessons learned through the course of this research, which could be applicable in the development of other usability studies, automated vision-based assessments and the development of assistive technologies for cognitively impaired older adults. Collaborative interdisciplinary teamwork, which included older adult with dementia participants, was key to enabling innovative advances that achieved the projects' research goals. Implications for Rehabilitation Products that are implicitly familiar and usable by older adults could foster independent activity completion, potentially reducing reliance on a caregiver. The computer-based automated tool can significantly reduce the time and effort required to perform product usability analysis, making this type of analysis more feasible. Interdisciplinary collaboration can result in a more holistic understanding of assistive technology research challenges and enable innovative solutions.

  1. TOPS On-Line: Automating the Construction and Maintenance of HTML Pages

    NASA Technical Reports Server (NTRS)

    Jones, Kennie H.

    1994-01-01

    After the Technology Opportunities Showcase (TOPS), in October, 1993, Langley Research Center's (LaRC) Information Systems Division (ISD) accepted the challenge to preserve the investment in information assembled in the TOPS exhibits by establishing a data base. Following the lead of several people at LaRC and others around the world, the HyperText Transport Protocol (HTTP) server and Mosaic were the obvious tools of choice for implementation. Initially, some TOPS exhibitors began the conventional approach of constructing HyperText Markup Language (HTML) pages of their exhibits as input to Mosaic. Considering the number of pages to construct, a better approach was conceived that would automate the construction of pages. This approach allowed completion of the data base construction in a shorter period of time using fewer resources than would have been possible with the conventional approach. It also provided flexibility for the maintenance and enhancement of the data base. Since that time, this approach has been used to automate construction of other HTML data bases. Through these experiences, it is concluded that the most effective use of the HTTP/Mosaic technology will require better tools and techniques for creating, maintaining and managing the HTML pages. The development and use of these tools and techniques are the subject of this document.

  2. Process development for automated solar-cell and module production. Task 4. Automated array assembly. Quarterly report No. 3

    SciTech Connect

    Hagerty, J. J.; Gifford, M.

    1981-04-15

    The Automated Lamination Station is mechanically complete and is currently undergoing final wiring. The high current driver and isolator boards have been completed and installed, and the main interface board is under construction. The automated vacuum chamber has had a minor redesign to increase stiffness and improve the cover open/close mechanism. Design of the Final Assembly Station has been completed and construction is underway.

  3. An Approach to Software Product Line Acquisition Planning

    DTIC Science & Technology

    2016-06-13

    Acquisition Organization summarizes • The program management and acquisition organization showing: – organizational chart for acquisition organization – all...workshop • Other key stakeholders and relationships (e.g., other services) • Who’s doing what -- overview of roles & responsibilities (e.g., IPT’s) • Working... relationships envisioned for product deployment and life cycle support 11 Army Product Line Workshop L. Jones, 12 Feb 09 © 2009 Carnegie Mellon

  4. Sex differences on a measure of conformity in automated teller machine lines.

    PubMed

    Reysen, Stephen; Reysen, Matthew B

    2004-10-01

    Sex differences in conformity were examined as participants approached two ATMs, one of which was occupied by three confederates and the other immediately available. The number of men and women in the line in front of one of the ATMs was manipulated (3 men or 3 women), and an unobtrusive observer recorded the sex of each participant. The results indicated that women were more likely than men to wait in line to use the ATM regardless of the makeup of the line. Thus, the present study provides evidence in favor of the idea that sex differences in conformity are evident on a common task performed in a natural setting.

  5. Selection and procurement of commercial parts for microsat product line

    NASA Astrophysics Data System (ADS)

    Lay, P.; Cavalin, O.; Chaminade, C.; Mouton, A.

    2002-12-01

    For the microsatellite product line named Myriade using, on a large scale, commercial parts, this paper presents the parts management strategy. The paper describes the adapted methodology with respect to the program risk/cost ratio and identifies the lessons learned from the selection and procurement process.

  6. Work-Based Courses: Bringing College to the Production Line

    ERIC Educational Resources Information Center

    Kobes, Deborah; Girardi, Amy

    2016-01-01

    Work-based courses are an innovative way to bring college to the production line by using the job as a learning lab. This toolkit provides guidance to community college administrators and faculty who are interested in bringing a work-based course model to their college. It contains video content and teaching tips that introduce the six steps of…

  7. DETAIL VIEW OF THE INITIAL PRODUCTION LINE OF THE FIRST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL VIEW OF THE INITIAL PRODUCTION LINE OF THE FIRST B-29 SHOWING THE SPLICING OF THE WINGS AND FUSELAGE. WHO, 1944 - Offutt Air Force Base, Glenn L. Martin-Nebraska Bomber Plant, Building D, Peacekeeper Drive, Bellevue, Sarpy County, NE

  8. GENERAL VIEW OF THE FINAL PRODUCTION LINE OF THE FIRST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GENERAL VIEW OF THE FINAL PRODUCTION LINE OF THE FIRST B-29 SHOWING THE LINK-BELT CONVEYOR SYSTEM AND WOOD BLOCK FLOORING. WHO, 1944 - Offutt Air Force Base, Glenn L. Martin-Nebraska Bomber Plant, Building D, Peacekeeper Drive, Bellevue, Sarpy County, NE

  9. Case study: developing product lines using ICD-9-CM codes.

    PubMed

    Benz, P D; Burnham, J

    1985-12-01

    In this marketing case study, Thomas Jefferson University Hospital used a product line approach to maximize the use of its resources. The method used, based on ICD-9-CM codes, fulfilled the demands of increased efficiency by encouraging customer-oriented thinking, enhancing communication with physicians and patients, and helping the institution to compete more effectively.

  10. Continuous determination of volatile products in anaerobic fermenters by on-line capillary gas chromatography.

    PubMed

    Diamantis, V; Melidis, P; Aivasidis, A

    2006-07-28

    Bio-ethanol and biogas produced during the anaerobic conversion of organic compounds has been a subject of great interest since the oil crisis of the 1970s. In ethanol fermentation and anaerobic treatment of wastewaters, end-product (ethanol) and intermediate-products (short-chain fatty acids, SCFA) cause inhibition that results in reduced process efficiency. Control of these constituents is of utmost importance for bioreactor optimization and process stability. Ethanol and SCFA can be detected with precision by capillary gas chromatography usually conducted in off-line measurements. In this work, an on-line monitoring and controlling system was developed and connected to the fermenter via an auto-sampling equipment, which could perform the feeding, filtration and dilution of the sample and final injection into the gas chromatograph through an automation-based programmed procedure. The sample was continuously pumped from the recycle stream of the bioreactor and treated using a microfiltration unit. The concentrate was returned to the reactor while the permeate was quantitatively mixed with an internal standard solution. The system comprised of a gas chromatograph with the flow cell and one-shot sampler and a PC with the appropriate software. The on-line measurement of ethanol and SCFA, directly from the liquid phase of an ethanol fermenter and a high-rate continuous mode anaerobic digester, was accomplished by gas chromatography. Also, this monitoring and controlling system was proved to be effective in the continuous fermentation of alcohol-free beer.

  11. [A new automated method to identify emission line star from massive spectra].

    PubMed

    Pan, Jing-Chang; Zhang, Cai-Ming; Wei, Peng; Luo, A-Li; Zhao, Yong-Heng

    2012-06-01

    Stellar spectra are characterized by obvious absorption lines or absorption bands, while those with emission lines are usually special stars such as cataclysmic variable stars (CVs), HerbigAe/Be etc. The further study of this kind of spectra is meaningful. The present paper proposed a new method to identify emission line stars (ELS) spectra automatically. After the continuum normalization is done for the original spectral flux, line detection is made by comparing the normalized flux with the mean and standard deviation of the flux in its neighbor region The results of the experiment on massive spectra from SDSS DR8 indicate that the method can identify ELS spectra completely and accurately. Since no complex transformation and computation are involved in this method, the identifying process is fast and it is ideal for the ELS detection in large sky survey projects like LAMOST and SDSS.

  12. Automated transmission line fault analysis using synchronized sampling at two ends

    SciTech Connect

    Kezunovic, M.; Perunicic, B.

    1996-02-01

    This paper introduces a new approach to fault analysis using synchronized sampling. A digital fault recorder with Global Positioning System (GPS) satellite receiver is the source of data for this approach. Fault analysis functions, such as fault detection, classification and location are implemented for a transmission line using synchronized samples from two ends of a line. This technique can be extremely fast, selective and accurate, providing fault analysis performance that can not easily be matched by other known techniques.

  13. Automated transmission line fault analysis using synchronized sampling at two ends

    SciTech Connect

    Kezunovic, M.; Perunicic, B.

    1995-12-31

    This paper introduces a new approach to fault analysis using synchronized sampling. A digital fault recorder with Global Positioning System (GPS) satellite receiver is the source of data for this approach. Fault analysis functions, such as fault detection, classification and location are implemented for a transmission line using synchronized samples from two ends of a line. This technique can be extremely fast, selective and accurate, providing fault analysis performance that can not easily be matched by other known techniques.

  14. Space Station Freedom automation and robotics: An assessment of the potential for increased productivity

    NASA Technical Reports Server (NTRS)

    Weeks, David J.; Zimmerman, Wayne F.; Swietek, Gregory E.; Reid, David H.; Hoffman, Ronald B.; Stammerjohn, Lambert W., Jr.; Stoney, William; Ghovanlou, Ali H.

    1990-01-01

    This report presents the results of a study performed in support of the Space Station Freedom Advanced Development Program, under the sponsorship of the Space Station Engineering (Code MT), Office of Space Flight. The study consisted of the collection, compilation, and analysis of lessons learned, crew time requirements, and other factors influencing the application of advanced automation and robotics, with emphasis on potential improvements in productivity. The lessons learned data collected were based primarily on Skylab, Spacelab, and other Space Shuttle experiences, consisting principally of interviews with current and former crew members and other NASA personnel with relevant experience. The objectives of this report are to present a summary of this data and its analysis, and to present conclusions regarding promising areas for the application of advanced automation and robotics technology to the Space Station Freedom and the potential benefits in terms of increased productivity. In this study, primary emphasis was placed on advanced automation technology because of its fairly extensive utilization within private industry including the aerospace sector. In contrast, other than the Remote Manipulator System (RMS), there has been relatively limited experience with advanced robotics technology applicable to the Space Station. This report should be used as a guide and is not intended to be used as a substitute for official Astronaut Office crew positions on specific issues.

  15. On-line analysis of biosignals for the automation of total and specific sleep deprivation in the rat.

    PubMed

    Vivaldi, Ennio A; Bassi, Alejandro; Estrada, Jorge; Garrido, Ignacio; Díaz, Javier; Ocampo-Garcés, Adrián

    2008-01-01

    A computer-based system that automates sleep studies, including sleep deprivation paradigms, is described. The system allows for total or REM-specific sleep deprivation and is based on a reliable, fast-responding, on-line state detection algorithm linked to a dependable intervention device. Behavioral state detection is achieved by dimension reduction of short-term EEG power spectrum. Interventions are made by serial outputs to servomotors that move a cage with different patterns and variable intensity. The system can adapt itself to individual characteristics and to changes in recording conditions. Customized protocols can be designed by defining the states or stages to be deprived, including scheduling temporal patterns. A detailed analysis of the relevant signals during and after deprivation is readily available. Data is presented from two experimental designs in rats. One consisted of specific REM-sleep short-term deprivation and the other of 10-hour total sleep deprivation. An outline of conceptual and practical considerations involved in the automation of laboratory set-ups oriented to biosignal analysis is provided. Careful monitoring of sleep EEG variables during sleep deprivation suggests peculiarities of brain functioning in that condition. A corollary is that sleep deprivation should not be considered to be merely a forced prolonged wakefulness.

  16. Automated pipeline for rapid production and screening of HIV-specific monoclonal antibodies using pichia pastoris.

    PubMed

    Shah, Kartik A; Clark, John J; Goods, Brittany A; Politano, Timothy J; Mozdzierz, Nicholas J; Zimnisky, Ross M; Leeson, Rachel L; Love, J Christopher; Love, Kerry R

    2015-12-01

    Monoclonal antibodies (mAbs) that bind and neutralize human pathogens have great therapeutic potential. Advances in automated screening and liquid handling have resulted in the ability to discover antigen-specific antibodies either directly from human blood or from various combinatorial libraries (phage, bacteria, or yeast). There remain, however, bottlenecks in the cloning, expression and evaluation of such lead antibodies identified in primary screens that hinder high-throughput screening. As such, "hit-to-lead identification" remains both expensive and time-consuming. By combining the advantages of overlap extension PCR (OE-PCR) and a genetically stable yet easily manipulatable microbial expression host Pichia pastoris, we have developed an automated pipeline for the rapid production and screening of full-length antigen-specific mAbs. Here, we demonstrate the speed, feasibility and cost-effectiveness of our approach by generating several broadly neutralizing antibodies against human immunodeficiency virus (HIV).

  17. Verification of Software Product Lines with Delta-Oriented Slicing

    NASA Astrophysics Data System (ADS)

    Bruns, Daniel; Klebanov, Vladimir; Schaefer, Ina

    Software product line (SPL) engineering is a well-known approach to develop industry-size adaptable software systems. SPL are often used in domains where high-quality software is desirable; the overwhelming product diversity, however, remains a challenge for assuring correctness. In this paper, we present delta-oriented slicing, an approach to reduce the deductive verification effort across an SPL where individual products are Java programs and their relations are described by deltas. On the specification side, we extend the delta language to deal with formal specifications. On the verification side, we combine proof slicing and similarity-guided proof reuse to ease the verification process.

  18. On-line sample preparation for the automated sequential determination of HG in blood, urine and waste water

    SciTech Connect

    Schlemmer, G.; Erler, W.

    1995-12-31

    The accurate determination of mercury in environmental and clinical samples such as waste water, urine or blood with the cold vapour technique requires a complete oxidation and stabilization of mercury in the liquid phase prior to its reduction. It has been shown that the oxidation of all relevant organo-mercury compounds in this type of matrix can be achieved on-line by an appropriate oxidizing agent used in an open microwave system coupled to a flow injection cold vapour system. The various matrices, however, are handled individually. Blood samples, for example are diluted and injected into a neutral carrier. The acid to start the reaction is added on-line only shortly before the sample enters the heating zone of the microwave oven. Urine and waste water on the other hand are acidified already in the autosampler vessel and the microwave digestion is used for completion of the oxidation only. In this application, blood, urine and waste water, three most commonly encountered matrices, were analyzed using the same FIAS and microwave parameters in an automated run. The time for one individual measurement including the on-line deposition is about 90s. The detection limits obtained with a mercury specific detector is about 20 nm/L for urine and waste water and 100 ng/L for blood.

  19. Evaluating space station applications of automation and robotics technologies from a human productivity point of view

    NASA Technical Reports Server (NTRS)

    Bard, J. F.

    1986-01-01

    The role that automation, robotics, and artificial intelligence will play in Space Station operations is now beginning to take shape. Although there is only limited data on the precise nature of the payoffs that these technologies are likely to afford there is a general consensus that, at a minimum, the following benefits will be realized: increased responsiveness to innovation, lower operating costs, and reduction of exposure to hazards. Nevertheless, the question arises as to how much automation can be justified with the technical and economic constraints of the program? The purpose of this paper is to present a methodology which can be used to evaluate and rank different approaches to automating the functions and tasks planned for the Space Station. Special attention is given to the impact of advanced automation on human productivity. The methodology employed is based on the Analytic Hierarchy Process. This permits the introduction of individual judgements to resolve the confict that normally arises when incomparable criteria underly the selection process. Because of the large number of factors involved in the model, the overall problem is decomposed into four subproblems individually focusing on human productivity, economics, design, and operations, respectively. The results from each are then combined to yield the final rankings. To demonstrate the methodology, an example is developed based on the selection of an on-orbit assembly system. Five alternatives for performing this task are identified, ranging from an astronaut working in space, to a dexterous manipulator with sensory feedback. Computational results are presented along with their implications. A final parametric analysis shows that the outcome is locally insensitive to all but complete reversals in preference.

  20. 40 CFR 90.703 - Production line testing by the manufacturer.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Production line testing by the... Manufacturer Production Line Testing Program § 90.703 Production line testing by the manufacturer. (a) Manufacturers of small SI engines shall test production line engines from each engine family according to...

  1. 40 CFR 1048.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false When must I test my production-line... Production-line Engines § 1048.301 When must I test my production-line engines? (a) If you produce engines... is evidence of a nonconformity, we may require you to test production-line engines under this...

  2. 40 CFR 1054.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... production-line engines? 1054.305 Section 1054.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... EQUIPMENT Production-line Testing § 1054.305 How must I prepare and test my production-line engines? This section describes how to prepare and test production-line engines. You must assemble the test engine in...

  3. 40 CFR 1054.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... production-line engines? 1054.305 Section 1054.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... EQUIPMENT Production-line Testing § 1054.305 How must I prepare and test my production-line engines? This section describes how to prepare and test production-line engines. You must assemble the test engine in...

  4. 40 CFR 90.703 - Production line testing by the manufacturer.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Production line testing by the... Manufacturer Production Line Testing Program § 90.703 Production line testing by the manufacturer. (a) Manufacturers of small SI engines shall test production line engines from each engine family according to...

  5. 40 CFR 1051.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false What production-line testing records... Production-Line Vehicles and Engines § 1051.345 What production-line testing records must I send to EPA? (a...: (1) Describe any facility used to test production-line vehicles or engines and state its location....

  6. 40 CFR 1042.305 - Preparing and testing production-line engines.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Preparing and testing production-line... AND VESSELS Testing Production-line Engines § 1042.305 Preparing and testing production-line engines. This section describes how to prepare and test production-line engines. You must assemble the...

  7. 40 CFR 1051.301 - When must I test my production-line vehicles or engines?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false When must I test my production-line... Production-Line Vehicles and Engines § 1051.301 When must I test my production-line vehicles or engines? (a... nonconformity, we may require you to test production-line engines under this subpart, or under 40 CFR part...

  8. 40 CFR 1054.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... production-line engines? 1054.305 Section 1054.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... EQUIPMENT Production-line Testing § 1054.305 How must I prepare and test my production-line engines? This section describes how to prepare and test production-line engines. You must assemble the test engine in...

  9. 40 CFR 1048.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false What production-line testing records... Testing Production-line Engines § 1048.345 What production-line testing records must I send to EPA? (a... information: (1) Describe any facility used to test production-line engines and state its location. (2)...

  10. 40 CFR 1054.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false When must I test my production-line... EQUIPMENT Production-line Testing § 1054.301 When must I test my production-line engines? (a) If you produce... if there is evidence of a nonconformity, we may require you to test production-line engines...

  11. 40 CFR 1054.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false When must I test my production-line... EQUIPMENT Production-line Testing § 1054.301 When must I test my production-line engines? (a) If you produce... if there is evidence of a nonconformity, we may require you to test production-line engines...

  12. 40 CFR 1048.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... production-line engines? 1048.305 Section 1048.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Testing Production-line Engines § 1048.305 How must I prepare and test my production-line engines? This section describes how to prepare and test production-line engines. You must assemble the test engine in...

  13. 40 CFR 90.703 - Production line testing by the manufacturer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Production line testing by the... Manufacturer Production Line Testing Program § 90.703 Production line testing by the manufacturer. (a) Manufacturers of small SI engines shall test production line engines from each engine family according to...

  14. 40 CFR 1054.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false What production-line testing records... EQUIPMENT Production-line Testing § 1054.345 What production-line testing records must I send to EPA? (a...) Describe any facility used to test production-line engines and state its location. (2) State the total...

  15. 40 CFR 1048.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... production-line engines? 1048.305 Section 1048.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Testing Production-line Engines § 1048.305 How must I prepare and test my production-line engines? This section describes how to prepare and test production-line engines. You must assemble the test engine in...

  16. 40 CFR 1051.301 - When must I test my production-line vehicles or engines?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false When must I test my production-line... Production-Line Vehicles and Engines § 1051.301 When must I test my production-line vehicles or engines? (a... nonconformity, we may require you to test production-line engines under this subpart, or under 40 CFR part...

  17. 40 CFR 1042.305 - Preparing and testing production-line engines.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Preparing and testing production-line... AND VESSELS Testing Production-line Engines § 1042.305 Preparing and testing production-line engines. This section describes how to prepare and test production-line engines. You must assemble the...

  18. 40 CFR 1054.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false When must I test my production-line... EQUIPMENT Production-line Testing § 1054.301 When must I test my production-line engines? (a) If you produce... if there is evidence of a nonconformity, we may require you to test production-line engines...

  19. 40 CFR 1048.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... production-line engines? 1048.305 Section 1048.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Testing Production-line Engines § 1048.305 How must I prepare and test my production-line engines? This section describes how to prepare and test production-line engines. You must assemble the test engine in...

  20. 40 CFR 1051.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false What production-line testing records... Production-Line Vehicles and Engines § 1051.345 What production-line testing records must I send to EPA? (a...: (1) Describe any facility used to test production-line vehicles or engines and state its location....

  1. 40 CFR 1048.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... production-line engines? 1048.305 Section 1048.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Testing Production-line Engines § 1048.305 How must I prepare and test my production-line engines? This section describes how to prepare and test production-line engines. You must assemble the test engine in...

  2. 40 CFR 90.703 - Production line testing by the manufacturer.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Production line testing by the... Manufacturer Production Line Testing Program § 90.703 Production line testing by the manufacturer. (a) Manufacturers of small SI engines shall test production line engines from each engine family according to...

  3. 40 CFR 1051.301 - When must I test my production-line vehicles or engines?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false When must I test my production-line... Production-Line Vehicles and Engines § 1051.301 When must I test my production-line vehicles or engines? (a... nonconformity, we may require you to test production-line engines under this subpart, or under 40 CFR part...

  4. 40 CFR 1048.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false When must I test my production-line... Production-line Engines § 1048.301 When must I test my production-line engines? (a) If you produce engines... nonconformity, we may require you to test production-line engines under this subpart, or under 40 CFR part...

  5. 40 CFR 1042.305 - Preparing and testing production-line engines.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Preparing and testing production-line... AND VESSELS Testing Production-line Engines § 1042.305 Preparing and testing production-line engines. This section describes how to prepare and test production-line engines. You must assemble the...

  6. 40 CFR 1054.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false When must I test my production-line... EQUIPMENT Production-line Testing § 1054.301 When must I test my production-line engines? (a) If you produce... if there is evidence of a nonconformity, we may require you to test production-line engines...

  7. 40 CFR 1054.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... production-line engines? 1054.305 Section 1054.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... EQUIPMENT Production-line Testing § 1054.305 How must I prepare and test my production-line engines? This section describes how to prepare and test production-line engines. You must assemble the test engine in...

  8. 40 CFR 1054.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... production-line engines? 1054.305 Section 1054.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... EQUIPMENT Production-line Testing § 1054.305 How must I prepare and test my production-line engines? This section describes how to prepare and test production-line engines. You must assemble the test engine in...

  9. 40 CFR 1054.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false What production-line testing records... EQUIPMENT Production-line Testing § 1054.345 What production-line testing records must I send to EPA? (a...) Describe any facility used to test production-line engines and state its location. (2) State the total...

  10. 40 CFR 1054.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false What production-line testing records... EQUIPMENT Production-line Testing § 1054.345 What production-line testing records must I send to EPA? (a...) Describe any facility used to test production-line engines and state its location. (2) State the total...

  11. 40 CFR 1048.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false When must I test my production-line... Production-line Engines § 1048.301 When must I test my production-line engines? (a) If you produce engines... nonconformity, we may require you to test production-line engines under this subpart, or under 40 CFR part...

  12. 40 CFR 1048.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false When must I test my production-line... Production-line Engines § 1048.301 When must I test my production-line engines? (a) If you produce engines... nonconformity, we may require you to test production-line engines under this subpart, or under 40 CFR part...

  13. 40 CFR 1051.301 - When must I test my production-line vehicles or engines?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false When must I test my production-line... Production-Line Vehicles and Engines § 1051.301 When must I test my production-line vehicles or engines? (a... nonconformity, we may require you to test production-line engines under this subpart, or under 40 CFR part...

  14. 40 CFR 1042.305 - Preparing and testing production-line engines.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Preparing and testing production-line... AND VESSELS Testing Production-line Engines § 1042.305 Preparing and testing production-line engines. This section describes how to prepare and test production-line engines. You must assemble the...

  15. 40 CFR 1051.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false What production-line testing records... Production-Line Vehicles and Engines § 1051.345 What production-line testing records must I send to EPA? (a...: (1) Describe any facility used to test production-line vehicles or engines and state its location....

  16. 40 CFR 1054.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false When must I test my production-line... EQUIPMENT Production-line Testing § 1054.301 When must I test my production-line engines? (a) If you produce... if there is evidence of a nonconformity, we may require you to test production-line engines...

  17. 40 CFR 1048.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false What production-line testing records... Testing Production-line Engines § 1048.345 What production-line testing records must I send to EPA? (a... information: (1) Describe any facility used to test production-line engines and state its location. (2)...

  18. 40 CFR 90.703 - Production line testing by the manufacturer.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Production line testing by the... Manufacturer Production Line Testing Program § 90.703 Production line testing by the manufacturer. (a) Manufacturers of small SI engines shall test production line engines from each engine family according to...

  19. 40 CFR 1051.301 - When must I test my production-line vehicles or engines?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false When must I test my production-line... Production-Line Vehicles and Engines § 1051.301 When must I test my production-line vehicles or engines? (a... nonconformity, we may require you to test production-line engines under this subpart, or under 40 CFR part...

  20. 40 CFR 1042.305 - Preparing and testing production-line engines.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Preparing and testing production-line... AND VESSELS Testing Production-line Engines § 1042.305 Preparing and testing production-line engines. This section describes how to prepare and test production-line engines. You must assemble the...

  1. 40 CFR 1048.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... production-line engines? 1048.305 Section 1048.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Testing Production-line Engines § 1048.305 How must I prepare and test my production-line engines? This section describes how to prepare and test production-line engines. You must assemble the test engine in...

  2. 40 CFR 1048.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false What production-line testing records... Testing Production-line Engines § 1048.345 What production-line testing records must I send to EPA? (a... information: (1) Describe any facility used to test production-line engines and state its location. (2)...

  3. 40 CFR 1048.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false When must I test my production-line... Production-line Engines § 1048.301 When must I test my production-line engines? (a) If you produce engines... nonconformity, we may require you to test production-line engines under this subpart, or under 40 CFR part...

  4. Automated fiber placement composite manufacturing: The mission at MSFC's Productivity Enhancement Complex

    NASA Technical Reports Server (NTRS)

    Vickers, John H.; Pelham, Larry I.

    1993-01-01

    Automated fiber placement is a manufacturing process used for producing complex composite structures. It is a notable leap to the state-of-the-art in technology for automated composite manufacturing. The fiber placement capability was established at the Marshall Space Flight Center's (MSFC) Productivity Enhancement Complex in 1992 in collaboration with Thiokol Corporation to provide materials and processes research and development, and to fabricate components for many of the Center's Programs. The Fiber Placement System (FPX) was developed as a distinct solution to problems inherent to other automated composite manufacturing systems. This equipment provides unique capabilities to build composite parts in complex 3-D shapes with concave and other asymmetrical configurations. Components with complex geometries and localized reinforcements usually require labor intensive efforts resulting in expensive, less reproducible components; the fiber placement system has the features necessary to overcome these conditions. The mechanical systems of the equipment have the motion characteristics of a filament winder and the fiber lay-up attributes of a tape laying machine, with the additional capabilities of differential tow payout speeds, compaction and cut-restart to selectively place the correct number of fibers where the design dictates. This capability will produce a repeatable process resulting in lower cost and improved quality and reliability.

  5. The Automated Plate Scanner On-Line Database of POSS I

    NASA Astrophysics Data System (ADS)

    Aldering, G.; Humphreys, R. M.; Odewahn, S.; Thurmes, P.

    We present details of our database constructed from POSS I plates digitized by the Automated Plate Scanner (APS) at the University of Minnesota. Both POSS I E and O plates covering those fields with |b| > 20 degrees (644 fields) have now been digitized. We have written a custom database engine, STARBASE , which is used to construct databases from reduced scan data. It can then be used to query the resulting databases. The astronomical community will have access to STARBASE , and hence to all fully reduced POSS I scan data. This access is being provided via the Astrophysical Data System (ADS) interface. Direct Internet use of STARBASE and its companion graphics X-window display package, STARPLOT , will also be provided in the near future. The release of plate databases will be incremental and is expected to take 1 - 2 yrs to complete. By the time of this conference we will be offering a fully calibrated test database covering 9 fields at the NGP through ADS. The test NGP database alone contains positions, magnitudes, colors, star and galaxy classification, and numerous other parameters for ~2 X 10**5 stars and ~10**5 galaxies. We also discuss our plans to digitize plates from the ``Luyten Red'' and POSS II surveys, and to provide network access to the digitized object rasters which have resulted from scanning POSS I.

  6. An automated method of on-line extraction coupled with flow injection and capillary electrophoresis for phytochemical analysis.

    PubMed

    Chen, Hongli; Ding, Xiuping; Wang, Min; Chen, Xingguo

    2010-11-01

    In this study, an automated system for phytochemical analysis was successfully fabricated for the first time in our laboratory. The system included on-line decocting, filtering, cooling, sample introducing, separation, and detection, which greatly simplified the sample preparation and shortened the analysis time. Samples from the decoction extract were drawn every 5 min through an on-line filter and a condenser pipe to the sample loop from which 20-μL samples were injected into the running buffer and transported into a split-flow interface coupling the flow injection and capillary electrophoresis systems. The separation of glycyrrhetinic acid (GTA) and glycyrrhizic acid (GA) took less than 5 min by using a 10 mM borate buffer (adjusted pH to 8.8) and +10 kV voltage. Calibration curves showed good linearity with correlation coefficients (R) more than 0.9991. The intra-day repeatabilities (n = 5, expressed as relative standard deviation) of the proposed system, obtained using GTA and GA standards, were 1.1% and 0.8% for migration time and 0.7% and 0.9% for peak area, respectively. The mean recoveries of GTA and GA in the off-line extract of Glycyrrhiza uralensis Fisch root were better than 99.0%. The limits of detection (signal-to-noise ratio = 3) of the proposed method were 6.2 μg/mL and 6.9 μg/mL for GTA and GA, respectively. The dynamic changes of GTA and GA on the decoction time were obtained during the on-line decoction process of Glycyrrhiza uralensis Fisch root.

  7. Automated DNA extraction platforms offer solutions to challenges of assessing microbial biofouling in oil production facilities

    PubMed Central

    2012-01-01

    The analysis of microbial assemblages in industrial, marine, and medical systems can inform decisions regarding quality control or mitigation. Modern molecular approaches to detect, characterize, and quantify microorganisms provide rapid and thorough measures unbiased by the need for cultivation. The requirement of timely extraction of high quality nucleic acids for molecular analysis is faced with specific challenges when used to study the influence of microorganisms on oil production. Production facilities are often ill equipped for nucleic acid extraction techniques, making the preservation and transportation of samples off-site a priority. As a potential solution, the possibility of extracting nucleic acids on-site using automated platforms was tested. The performance of two such platforms, the Fujifilm QuickGene-Mini80™ and Promega Maxwell®16 was compared to a widely used manual extraction kit, MOBIO PowerBiofilm™ DNA Isolation Kit, in terms of ease of operation, DNA quality, and microbial community composition. Three pipeline biofilm samples were chosen for these comparisons; two contained crude oil and corrosion products and the third transported seawater. Overall, the two more automated extraction platforms produced higher DNA yields than the manual approach. DNA quality was evaluated for amplification by quantitative PCR (qPCR) and end-point PCR to generate 454 pyrosequencing libraries for 16S rRNA microbial community analysis. Microbial community structure, as assessed by DGGE analysis and pyrosequencing, was comparable among the three extraction methods. Therefore, the use of automated extraction platforms should enhance the feasibility of rapidly evaluating microbial biofouling at remote locations or those with limited resources. PMID:23168231

  8. Overview of a Proactive Software Product Line Acquisition Approach

    DTIC Science & Technology

    2016-06-13

    will operate from an organizational and technical management perspective and how it will fully accommodate all aspects of the on-going development and...Section L – Instructions to Offerrors 1. Describe how quality attribute scenarios resulting from the QAW will be integrated into the product line...requirements baseline and managed from that point forward. 2. Describe how proposed changes to software component and other asset requirements will be

  9. Simulation of Production Lines Supply within Internal Logistics Systems

    NASA Astrophysics Data System (ADS)

    Čujan, Zdeněk

    2016-11-01

    Supplying of production lines is a complex logistic process, which is very difficult with regards to the requirements of its operation and scheduling. For this reason, this supplying process demands an increased attention. Application of a computer simulation is an efficient tool suitable for solution of the supplying logistic questions. In this paper the application possibilities of the software Tecnomatix Plant Simumlation specified for simulation of the supplying process by means of the system Milk Run will be presented.

  10. Automated Measurement of Crack Length and Load Line Displacement at Elevated Temperature,

    DTIC Science & Technology

    1988-02-01

    LINE DISPLACEMENT AT ELEVATED TEMPERATURE Test results reported in the literature show that, in creep cracking tests at elevated temperature under steady...set-up developed for elevated temperature creep cracking test in which crack length was measured with the electrical potential drop method and load...reported in the literature show that in creep cracking tests at elevated temperature under steady load, the crack growth rate correlates best with the

  11. Automated measurement of the EUREKA EU213 excimer laser pulse-forming line

    NASA Astrophysics Data System (ADS)

    Boardman, Allan D.; Hodgson, Elizabeth M.; Spence, A. J.; Wilkins, M.; Wu, Jian; Ashton, J. A.

    1990-08-01

    This paper describes part of the EUREKA Eurolaser project EU213, to build an excimer laser. The emphasis is on control and monitoring systems. The performance of a test-bed laser built at Salford will be described. In the design discussed, two voltage components are generated separately and combined at the laser head to form a pumping pulse. A "magnetic switch" is used to isolate the two parts of the transmission line'. A theoretical analysis of the sustainer section of the line has been carried out and compared with measurements made using a dummy load in place of the laser head. A control system is discussed that is being developed to monitor the shape of each laser pulse at a high repetition rate. The control system is designed to protect the laser from damage. The construction of various conventional probes, and the progress towards various fibre probes will be reported with emphasis on measuring fast current pulses on the various parts of the line.

  12. Myxobacterial natural product assembly lines: fascinating examples of curious biochemistry.

    PubMed

    Wenzel, Silke Christine; Müller, Rolf

    2007-12-01

    Over the last 20 years myxobacteria have made their way from highly exotic organisms to one of the major sources of microbial natural products with interesting biological activities. Recent progress towards achieving a better understanding of the genetics and the biochemistry of myxobacterial secondary metabolism, revealed the involvement of numerous exceptional combinations of polyketide synthases and nonribosomal peptide synthetases operating far from textbook biosynthetic logic. In this Highlight, selected examples of recently described systems are discussed in comparison to all myxobacterial natural product assembly lines known to date.

  13. Developing Software Product Lines for Science Data Systems (Invited)

    NASA Astrophysics Data System (ADS)

    Crichton, D. J.; Hughes, J. S.; Mattmann, C. A.; Law, E.; Hardman, S.

    2010-12-01

    Software reuse has traditionally been a challenging proposition. While the allure of reusing software has great appeal to increasing stability and reducing software costs, there has been limited success in building software that can be efficiently reused. In many cases, reuse is limited to the reuse of software expertise or repurposing existing software code. While there are certainly cultural challenges involved in reusing software, much of the challenge can be traced back to the strategy involved in developing reusable software. The discipline of software architecture plays an important role since software reuse is highly dependent on developing a reference architecture that can be used for the construction of software product lines. All too often software reference architectures are implicit or are highly focused on specific implementations. The challenge is developing a reference architecture that identifies core patterns that exist across many systems at appropriate level of abstraction and then developing a reference implementation that can serve as a reusable product line. At the Jet Propulsion Laboratory (JPL), we have been involved in developing both reference architectures and software product lines for science data systems [1]. These reference architectures identify common patterns in data capture, data processing and product generation, data discovery, data access and distribution, and data movement. How those patterns are implemented is critical to establishing a reusable architecture. In addition, the separation of the technical and data architecture has proven critical to allowing for such product lines to be applied to multiple disciplines, where domain information models are developed and applied, rather than directly integrated into software. This presentation will focus on defining software architecture and product lines, the development of these capabilities at JPL, and the application to earth, planetary and biomedical domains. [1] C. Mattmann

  14. SAGA: A project to automate the management of software production systems

    NASA Technical Reports Server (NTRS)

    Campbell, Roy H.; Beckman-Davies, C. S.; Benzinger, L.; Beshers, G.; Laliberte, D.; Render, H.; Sum, R.; Smith, W.; Terwilliger, R.

    1986-01-01

    Research into software development is required to reduce its production cost and to improve its quality. Modern software systems, such as the embedded software required for NASA's space station initiative, stretch current software engineering techniques. The requirements to build large, reliable, and maintainable software systems increases with time. Much theoretical and practical research is in progress to improve software engineering techniques. One such technique is to build a software system or environment which directly supports the software engineering process, i.e., the SAGA project, comprising the research necessary to design and build a software development which automates the software engineering process. Progress under SAGA is described.

  15. Automated apparatus for solvent separation of a coal liquefaction product stream

    DOEpatents

    Schweighardt, Frank K.

    1985-01-01

    An automated apparatus for the solvent separation of a coal liquefaction product stream that operates continuously and unattended and eliminates potential errors resulting from subjectivity and the aging of the sample during analysis. In use of the apparatus, metered amounts of one or more solvents are passed sequentially through a filter containing the sample under the direction of a microprocessor control means. The mixture in the filter is agitated by means of ultrasonic cavitation for a timed period and the filtrate is collected. The filtrate of each solvent extraction is collected individually and the residue on the filter element is collected to complete the extraction process.

  16. Evaluation of robot automated chromogenic substrate LAL endotoxin assay method for pharmaceutical products testing.

    PubMed

    Tsuji, K; Martin, P A

    1985-01-01

    The robot automated chromogenic substrate LAL assay method was evaluated for endotoxin testing using three lots each of 12 pharmaceutical products. As many as 216 assays, including automated standard curve construction and sample preparation, can be performed in a single day of unattended operation. The method is linear (r greater than .99) in the range of 0 to 0.2 EU/ml. The precision of the method determined by assaying a lot of calcium gluconate for four days was 6%, 10%, and 10% for within an assay block, between assay blocks, and between assay days, respectively. Recovery of endotoxin when spiked into products ranged from 81% to 110% and was within the statistical variation (2 sigma limit) of the method. The endotoxin levels detected in a biological raw material by the chromogenic substrate assay method correlated well with that of the gel-clot LAL assay method. The endotoxin content of the majority of the pharmaceutical products tested was well below the sensitivity of both the chromogenic substrate and the gel clot LAL assay methods.

  17. Automated production of [18F]VAT suitable for clinical PET study of vesicular acetylcholine transporter

    PubMed Central

    Yue, Xuyi; Bognar, Christopher; Zhang, Xiang; Gaehle, Gregory; Moerlein, Stephen M.; Perlmutter, Joel S.; Tu, Zhude

    2015-01-01

    Automated production of a promising radiopharmaceutical (-)-(1-(8-(2-[18F]fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-piperidin-4-yl)(4-fluorophenyl)methanone ([18F]VAT) for vesicular acetylcholine transporter(VAChT) was achieved using a two-step procedure in a current good manufacturing practices fashion. The production of [18F]VAT was accomplished in approximately 140 min, with radiochemical yield of ~15.0% (decay corrected), specific activity > 111 GBq/μmol, radiochemical purity > 99% and mass of VAT ~3.4 μg/batch (n > 10). The radiopharmaceutical product meets all quality control criteria for human use, and is suitable for clinical PET studies of VAChT. PMID:26408913

  18. Automated 2D-3D registration of a radiograph and a cone beam CT using line-segment enhancement

    SciTech Connect

    Munbodh, Reshma; Jaffray, David A.; Moseley, Douglas J.; Chen Zhe; Knisely, Jonathan P.S.; Cathier, Pascal; Duncan, James S.

    2006-05-15

    The objective of this study was to develop a fully automated two-dimensional (2D)-three-dimensional (3D) registration framework to quantify setup deviations in prostate radiation therapy from cone beam CT (CBCT) data and a single AP radiograph. A kilovoltage CBCT image and kilovoltage AP radiograph of an anthropomorphic phantom of the pelvis were acquired at 14 accurately known positions. The shifts in the phantom position were subsequently estimated by registering digitally reconstructed radiographs (DRRs) from the 3D CBCT scan to the AP radiographs through the correlation of enhanced linear image features mainly representing bony ridges. Linear features were enhanced by filtering the images with ''sticks,'' short line segments which are varied in orientation to achieve the maximum projection value at every pixel in the image. The mean (and standard deviations) of the absolute errors in estimating translations along the three orthogonal axes in millimeters were 0.134 (0.096) AP(out-of-plane), 0.021 (0.023) ML and 0.020 (0.020) SI. The corresponding errors for rotations in degrees were 0.011 (0.009) AP, 0.029 (0.016) ML (out-of-plane), and 0.030 (0.028) SI (out-of-plane). Preliminary results with megavoltage patient data have also been reported. The results suggest that it may be possible to enhance anatomic features that are common to DRRs from a CBCT image and a single AP radiography of the pelvis for use in a completely automated and accurate 2D-3D registration framework for setup verification in prostate radiotherapy. This technique is theoretically applicable to other rigid bony structures such as the cranial vault or skull base and piecewise rigid structures such as the spine.

  19. Automating data analysis during the inspection of boiler tubes using line scanning thermography

    NASA Astrophysics Data System (ADS)

    Ley, Obdulia; Momeni, Sepand; Ostroff, Jason; Godinez, Valery

    2012-05-01

    Failures in boiler waterwalls can occur when a relatively small amount of corrosion and loss of metal have been experienced. This study presents our efforts towards the application of Line Scanning Thermography (LST) for the analysis of thinning in boiler waterwall tubing. LST utilizes a line heat source to thermally excite the surface to be inspected and an infrared detector to record the transient surface temperature increase observed due to the presence of voids, thinning or other defects. In waterwall boiler tubes the defects that can be detected using LST correspond to corrosion pitting, hydrogen damage and wall thinning produced by inadequate burner heating or problems with the water chemistry. In this paper we discuss how the LST technique is implemented to determine thickness from the surface temperature data, and we describe our efforts towards developing a semiautomatic analysis tool to speed up the time between scanning, reporting and implementing repairs. We compare the density of data produced by the common techniques used to assess wall thickness and the data produced by LST.

  20. 40 CFR 1048.310 - How must I select engines for production-line testing?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... production-line testing? 1048.310 Section 1048.310 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Testing Production-line Engines § 1048.310 How must I select engines for production-line testing? (a) Use... end of the assembly line for each engine family. (c) Calculate the required sample size for...

  1. 40 CFR 1048.310 - How must I select engines for production-line testing?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... production-line testing? 1048.310 Section 1048.310 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Testing Production-line Engines § 1048.310 How must I select engines for production-line testing? (a) Use... end of the assembly line for each engine family. (c) Calculate the required sample size for...

  2. 40 CFR 1048.310 - How must I select engines for production-line testing?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... production-line testing? 1048.310 Section 1048.310 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Testing Production-line Engines § 1048.310 How must I select engines for production-line testing? (a) Use... end of the assembly line for each engine family. (c) Calculate the required sample size for...

  3. 40 CFR 1048.310 - How must I select engines for production-line testing?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... production-line testing? 1048.310 Section 1048.310 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Testing Production-line Engines § 1048.310 How must I select engines for production-line testing? (a) Use... end of the assembly line for each engine family. (c) Calculate the required sample size for...

  4. Automated Solar-Array Assembly

    NASA Technical Reports Server (NTRS)

    Soffa, A.; Bycer, M.

    1982-01-01

    Large arrays are rapidly assembled from individual solar cells by automated production line developed for NASA's Jet Propulsion Laboratory. Apparatus positions cells within array, attaches interconnection tabs, applies solder flux, and solders interconnections. Cells are placed in either straight or staggered configurations and may be connected either in series or in parallel. Are attached at rate of one every 5 seconds.

  5. Automated Flight Dynamics Product Generation for the EOS AM-1 Spacecraft

    NASA Technical Reports Server (NTRS)

    Matusow, Carla

    1999-01-01

    As part of NASA's Earth Science Enterprise, the Earth Observing System (EOS) AM-1 spacecraft is designed to monitor long-term, global, environmental changes. Because of the complexity of the AM-1 spacecraft, the mission operations center requires more than 80 distinct flight dynamics products (reports). To create these products, the AM-1 Flight Dynamics Team (FDT) will use a combination of modified commercial software packages (e.g., Analytical Graphic's Satellite ToolKit) and NASA-developed software applications. While providing the most cost-effective solution to meeting the mission requirements, the integration of these software applications raises several operational concerns: (1) Routine product generation requires knowledge of multiple applications executing on variety of hardware platforms. (2) Generating products is a highly interactive process requiring a user to interact with each application multiple times to generate each product. (3) Routine product generation requires several hours to complete. (4) User interaction with each application introduces the potential for errors, since users are required to manually enter filenames and input parameters as well as run applications in the correct sequence. Generating products requires some level of flight dynamics expertise to determine the appropriate inputs and sequencing. To address these issues, the FDT developed an automation software tool called AutoProducts, which runs on a single hardware platform and provides all necessary coordination and communication among the various flight dynamics software applications. AutoProducts, autonomously retrieves necessary files, sequences and executes applications with correct input parameters, and deliver the final flight dynamics products to the appropriate customers. Although AutoProducts will normally generate pre-programmed sets of routine products, its graphical interface allows for easy configuration of customized and one-of-a-kind products. Additionally, AutoProducts

  6. Automated system for generation of soil moisture products for agricultural drought assessment

    NASA Astrophysics Data System (ADS)

    Raja Shekhar, S. S.; Chandrasekar, K.; Sesha Sai, M. V. R.; Diwakar, P. G.; Dadhwal, V. K.

    2014-11-01

    Drought is a frequently occurring disaster affecting lives of millions of people across the world every year. Several parameters, indices and models are being used globally to forecast / early warning of drought and monitoring drought for its prevalence, persistence and severity. Since drought is a complex phenomenon, large number of parameter/index need to be evaluated to sufficiently address the problem. It is a challenge to generate input parameters from different sources like space based data, ground data and collateral data in short intervals of time, where there may be limitation in terms of processing power, availability of domain expertise, specialized models & tools. In this study, effort has been made to automate the derivation of one of the important parameter in the drought studies viz Soil Moisture. Soil water balance bucket model is in vogue to arrive at soil moisture products, which is widely popular for its sensitivity to soil conditions and rainfall parameters. This model has been encoded into "Fish-Bone" architecture using COM technologies and Open Source libraries for best possible automation to fulfill the needs for a standard procedure of preparing input parameters and processing routines. The main aim of the system is to provide operational environment for generation of soil moisture products by facilitating users to concentrate on further enhancements and implementation of these parameters in related areas of research, without re-discovering the established models. Emphasis of the architecture is mainly based on available open source libraries for GIS and Raster IO operations for different file formats to ensure that the products can be widely distributed without the burden of any commercial dependencies. Further the system is automated to the extent of user free operations if required with inbuilt chain processing for every day generation of products at specified intervals. Operational software has inbuilt capabilities to automatically

  7. Production implementation of fully automated, closed loop cure control for advanced composite structures

    NASA Astrophysics Data System (ADS)

    Johnson, Sean A.; Roberts, Nancy K.

    Economic of advanced composite part production requires development and use of the most aggressive cure cycles possible without sacrificing quality. As cure cycles are shortened and heating rates increase, tolerance windows for process parameters become increasingly narrow. These factors are intensified by condensation curing systems which generate large amounts of volatiles. Management of the situation requires fully automated, closed loop process control and a fundamental understanding of the material system used for the application. No turnkey system for this application is currently available. General Dynamics Pomona Division (GD/PD) has developed an integrated closed loop control system which is now being proofed in production. Realization of this system will enable cure time reductions of nearly 50 percent, while increasing yield and maintaining quality.

  8. Automated information system for analysis and prediction of production situations in blast furnace plant

    NASA Astrophysics Data System (ADS)

    Lavrov, V. V.; Spirin, N. A.

    2016-09-01

    Advances in modern science and technology are inherently connected with the development, implementation, and widespread use of computer systems based on mathematical modeling. Algorithms and computer systems are gaining practical significance solving a range of process tasks in metallurgy of MES-level (Manufacturing Execution Systems - systems controlling industrial process) of modern automated information systems at the largest iron and steel enterprises in Russia. This fact determines the necessity to develop information-modeling systems based on mathematical models that will take into account the physics of the process, the basics of heat and mass exchange, the laws of energy conservation, and also the peculiarities of the impact of technological and standard characteristics of raw materials on the manufacturing process data. Special attention in this set of operations for metallurgic production is devoted to blast-furnace production, as it consumes the greatest amount of energy, up to 50% of the fuel used in ferrous metallurgy. The paper deals with the requirements, structure and architecture of BF Process Engineer's Automated Workstation (AWS), a computer decision support system of MES Level implemented in the ICS of the Blast Furnace Plant at Magnitogorsk Iron and Steel Works. It presents a brief description of main model subsystems as well as assumptions made in the process of mathematical modelling. Application of the developed system allows the engineering and process staff to analyze online production situations in the blast furnace plant, to solve a number of process tasks related to control of heat, gas dynamics and slag conditions of blast-furnace smelting as well as to calculate the optimal composition of blast-furnace slag, which eventually results in increasing technical and economic performance of blast-furnace production.

  9. A prototype for automation of land-cover products from Landsat Surface Reflectance Data Records

    NASA Astrophysics Data System (ADS)

    Rover, J.; Goldhaber, M. B.; Steinwand, D.; Nelson, K.; Coan, M.; Wylie, B. K.; Dahal, D.; Wika, S.; Quenzer, R.

    2014-12-01

    Landsat data records of surface reflectance provide a three-decade history of land surface processes. Due to the vast number of these archived records, development of innovative approaches for automated data mining and information retrieval were necessary. Recently, we created a prototype utilizing open source software libraries for automatically generating annual Anderson Level 1 land cover maps and information products from data acquired by the Landsat Mission for the years 1984 to 2013. The automated prototype was applied to two target areas in northwestern and east-central North Dakota, USA. The approach required the National Land Cover Database (NLCD) and two user-input target acquisition year-days. The Landsat archive was mined for scenes acquired within a 100-day window surrounding these target dates, and then cloud-free pixels where chosen closest to the specified target acquisition dates. The selected pixels were then composited before completing an unsupervised classification using the NLCD. Pixels unchanged in pairs of the NLCD were used for training decision tree models in an iterative process refined with model confidence measures. The decision tree models were applied to the Landsat composites to generate a yearly land cover map and related information products. Results for the target areas captured changes associated with the recent expansion of oil shale production and agriculture driven by economics and policy, such as the increase in biofuel production and reduction in Conservation Reserve Program. Changes in agriculture, grasslands, and surface water reflect the local hydrological conditions that occurred during the 29-year span. Future enhancements considered for this prototype include a web-based client, ancillary spatial datasets, trends and clustering algorithms, and the forecasting of future land cover.

  10. Automated kidney detection for 3D ultrasound using scan line searching

    NASA Astrophysics Data System (ADS)

    Noll, Matthias; Nadolny, Anne; Wesarg, Stefan

    2016-04-01

    Ultrasound (U/S) is a fast and non-expensive imaging modality that is used for the examination of various anatomical structures, e.g. the kidneys. One important task for automatic organ tracking or computer-aided diagnosis is the identification of the organ region. During this process the exact information about the transducer location and orientation is usually unavailable. This renders the implementation of such automatic methods exceedingly challenging. In this work we like to introduce a new automatic method for the detection of the kidney in 3D U/S images. This novel technique analyses the U/S image data along virtual scan lines. Here, characteristic texture changes when entering and leaving the symmetric tissue regions of the renal cortex are searched for. A subsequent feature accumulation along a second scan direction produces a 2D heat map of renal cortex candidates, from which the kidney location is extracted in two steps. First, the strongest candidate as well as its counterpart are extracted by heat map intensity ranking and renal cortex size analysis. This process exploits the heat map gap caused by the renal pelvis region. Substituting the renal pelvis detection with this combined cortex tissue feature increases the detection robustness. In contrast to model based methods that generate characteristic pattern matches, our method is simpler and therefore faster. An evaluation performed on 61 3D U/S data sets showed, that in 55 cases showing none or minor shadowing the kidney location could be correctly identified.

  11. Using high-dimensional propensity scores to automate confounding control in a distributed medical product safety surveillance system.

    PubMed

    Rassen, Jeremy A; Schneeweiss, Sebastian

    2012-01-01

    Distributed medical product safety monitoring systems such as the Sentinel System, to be developed as a part of Food and Drug Administration's Sentinel Initiative, will require automation of large parts of the safety evaluation process to achieve the necessary speed and scale at reasonable cost without sacrificing validity. Although certain functions will require investigator intervention, confounding control is one area that can largely be automated. The high-dimensional propensity score (hd-PS) algorithm is one option for automated confounding control in longitudinal healthcare databases. In this article, we discuss the use of hd-PS for automating confounding control in sequential database cohort studies, as applied to safety monitoring systems. In particular, we discuss the robustness of the covariate selection process, the potential for over- or under-selection of variables including the possibilities of M-bias and Z-bias, the computation requirements, the practical considerations in a federated database network, and the cases where automated confounding adjustment may not function optimally. We also outline recent improvements to the algorithm and show how the algorithm has performed in several published studies. We conclude that despite certain limitations, hd-PS offers substantial advantages over non-automated alternatives in active product safety monitoring systems.

  12. 40 CFR 1045.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... requirements of 40 CFR part 1045. We have not changed production processes or quality-control procedures for... 40 Protection of Environment 33 2011-07-01 2011-07-01 false What production-line testing records... VESSELS Testing Production-line Engines § 1045.345 What production-line testing records must I send to...

  13. 77 FR 61742 - Certain Lined Paper Products From India: Preliminary Results of Countervailing Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-11

    ... International Trade Administration Certain Lined Paper Products From India: Preliminary Results of... administrative review of the countervailing duty order on certain lined paper products from India. The period of... subject to the order is certain lined paper products. The products are currently classifiable under...

  14. 40 CFR 1054.310 - How must I select engines for production-line testing?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... production-line testing? 1054.310 Section 1054.310 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... EQUIPMENT Production-line Testing § 1054.310 How must I select engines for production-line testing? (a) Test... engine families with projected U.S.-directed production volume of at least 1,600, the test periods...

  15. 40 CFR 1054.310 - How must I select engines for production-line testing?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... production-line testing? 1054.310 Section 1054.310 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... EQUIPMENT Production-line Testing § 1054.310 How must I select engines for production-line testing? (a) Test... engine families with projected U.S.-directed production volume of at least 1,600, the test periods...

  16. 40 CFR 1054.310 - How must I select engines for production-line testing?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... production-line testing? 1054.310 Section 1054.310 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... EQUIPMENT Production-line Testing § 1054.310 How must I select engines for production-line testing? (a) Test... engine families with projected U.S.-directed production volume of at least 1,600, the test periods...

  17. 40 CFR 1054.310 - How must I select engines for production-line testing?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... production-line testing? 1054.310 Section 1054.310 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... EQUIPMENT Production-line Testing § 1054.310 How must I select engines for production-line testing? (a) Test... engine families with projected U.S.-directed production volume of at least 1,600, the test periods...

  18. Automated, on-line quantification of left ventricular dimensions and function by echocardiography with backscatter imaging and lateral gain compensation.

    PubMed

    Pérez, J E; Klein, S C; Prater, D M; Fraser, C E; Cardona, H; Waggoner, A D; Holland, M R; Miller, J G; Sobel, B E

    1992-11-01

    To provide on-line quantification of left ventricular cavity dimensions and function by echocardiography 60 control subjects and 10 patients with cardiac dysfunction were studied. A novel, ultrasound imaging system was used which was developed to detect and track, in real time, ventricular endocardial blood boundaries based on quantitative assessment of acoustic properties of tissue. In addition, lateral gain compensation, a robust and novel image enhancement procedure, was used to provide instantaneous measurement and display of cavity areas and functional indexes on a beat-by-beat basis within regions of interest drawn around the blood pool cavity. In control subjects, short-axis end-diastolic area averaged 13.1 +/- 3.7 cm2 (SD), end-systolic area 5.9 +/- 2.7 cm2, and fractional area change 55.6 +/- 11.2%. Apical views yielded corresponding values of 23.8 +/- 4.5 cm2, 15.5 +/- 3.4 cm2 and 34.7 +/- 7.8%. Instantaneous peak rate of cavity area change approximated 50 cm2/s in systole and 60 cm2/s in diastole in each view. Serial measurements of area and functional index were reproducible over intervals of 2 to 3 weeks. Patients with dilated ventricles exhibited average apical view area values of 49.1 +/- 6.1 cm2 and 43.1 +/- 4.9 cm2 in diastole and systole with a fractional area change of 12.2 +/- 3.0%. Thus, results with on-line echocardiographic backscatter imaging-assisted automated edge detection are reproducible and capable of delineating cardiac dysfunction conveniently, promptly and serially at the bedside.

  19. On-line automated evaluation of lipid nanoparticles transdermal permeation using Franz diffusion cell and low-pressure chromatography.

    PubMed

    Alves, Ana Catarina; Ramos, Inês I; Nunes, Cláudia; Magalhães, Luís M; Sklenářová, Hana; Segundo, Marcela A; Lima, José L F C; Reis, Salette

    2016-01-01

    A low-pressure liquid chromatography system for the on-line quantification of caffeine loaded into lipid nanoparticles that permeates pig skin was developed. The apparatus includes a Franz diffusion cell with computer-controlled sampling that allows collection of acceptor solution with automatic compensation for sample withdrawing, and a C-18 reversed-phase monolithic column integrated in a typical Flow Injection Analysis (FIA) set-up where separation between caffeine and other matrix elements is performed before spectrophotometric quantification at 273 nm. Several parameters regarding chromatographic analysis (propulsion element, column length, mobile phase composition, and flow rate) were studied along with the establishment of the sampling procedure. Under the selected conditions (monolithic column Chromolith® RP-18 15 mm × 4.6 mm i.d., acetonitrile:water 10:90 (v/v), flow rate 0.45 mL min(-1)) a detection limit of 4 μM and RSD values for caffeine concentration <2% were achieved. High recovery values were obtained when Hepes buffer incubated as acceptor solution in presence of pig skin for 8 h was spiked with caffeine (103±5%). The developed system also accounts for low organic solvent consumption, low operating costs, low generation of waste and high sample throughput (24 h(-1)). Due to the real time automated sampling and high throughput, transdermal permeation profiles of nanoformulations can be established within a time frame seldom observed by conventional techniques.

  20. Expert Systems Development Through Software Product Lines Techniques

    NASA Astrophysics Data System (ADS)

    Cabello, María Eugenia; Ramos, Isidro

    This chapter deals with expert systems (ES) development as the final product of a software product line (SPL). We take into account software variability management in the ES domain. Two kinds of variability emerge: variability in the behavior as well as in the structure of such systems. Experts' knowledge is captured using domain conceptual models in order to manage the variability and functionality of the ES. The ES are constructed using our baseline-oriented modeling (BOM) approach. BOM is a framework that automatically generates software applications as PRISMA architectural models by using SPL techniques. We follow the model-driven architecture (MDA) initiative for building domain models, which are automatically transformed into executable applications.

  1. Intelligent Case Based Decision Support System for Online Diagnosis of Automated Production System

    NASA Astrophysics Data System (ADS)

    Ben Rabah, N.; Saddem, R.; Ben Hmida, F.; Carre-Menetrier, V.; Tagina, M.

    2017-01-01

    Diagnosis of Automated Production System (APS) is a decision-making process designed to detect, locate and identify a particular failure caused by the control law. In the literature, there are three major types of reasoning for industrial diagnosis: the first is model-based, the second is rule-based and the third is case-based. The common and major limitation of the first and the second reasonings is that they do not have automated learning ability. This paper presents an interactive and effective Case Based Decision Support System for online Diagnosis (CB-DSSD) of an APS. It offers a synergy between the Case Based Reasoning (CBR) and the Decision Support System (DSS) in order to support and assist Human Operator of Supervision (HOS) in his/her decision process. Indeed, the experimental evaluation performed on an Interactive Training System for PLC (ITS PLC) that allows the control of a Programmable Logic Controller (PLC), simulating sensors or/and actuators failures and validating the control algorithm through a real time interactive experience, showed the efficiency of our approach.

  2. Automated Planning of Science Products Based on Nadir Overflights and Alerts for Onboard and Ground Processing

    NASA Technical Reports Server (NTRS)

    Chien, Steve A.; McLaren, David A.; Rabideau, Gregg R.; Mandl, Daniel; Hengemihle, Jerry

    2013-01-01

    A set of automated planning algorithms is the current operations baseline approach for the Intelligent Payload Module (IPM) of the proposed Hyper spectral Infrared Imager (HyspIRI) mission. For this operations concept, there are only local (e.g. non-depletable) operations constraints, such as real-time downlink and onboard memory, and the forward sweeping algorithm is optimal for determining which science products should be generated onboard and on ground based on geographical overflights, science priorities, alerts, requests, and onboard and ground processing constraints. This automated planning approach was developed for the HyspIRI IPM concept. The HyspIRI IPM is proposed to use an X-band Direct Broadcast (DB) capability that would enable data to be delivered to ground stations virtually as it is acquired. However, the HyspIRI VSWIR and TIR instruments will produce approximately 1 Gbps data, while the DB capability is 15 Mbps for a approx. =60X oversubscription. In order to address this mismatch, this innovation determines which data to downlink based on both the type of surface the spacecraft is overflying, and the onboard processing of data to detect events. For example, when the spacecraft is overflying Polar Regions, it might downlink a snow/ice product. Additionally, the onboard software will search for thermal signatures indicative of a volcanic event or wild fire and downlink summary information (extent, spectra) when detected, thereby reducing data volume. The planning system described above automatically generated the IPM mission plan based on requested products, the overflight regions, and available resources.

  3. Decreasing costs of ground data processing system development using a software product line

    NASA Technical Reports Server (NTRS)

    Chaffin, Brian

    2005-01-01

    In this paper, I describe software product lines and why a Ground Data Processing System should use one. I also describe how to develop a software product line, using examples from an imaginary Ground Data Processing System.

  4. Process development for automated solar cell and module production. Task 4: automated array assembly. Quarterly report No. 5

    SciTech Connect

    Hagerty, J.J.

    1980-01-31

    Construction of an automated solar cell layup and interconnect system is now complete. This system incorporates a Unimate 2000 B industrial robot with an end effector consisting of a vacuum pick up and induction heating coil. The robot interfaces with a smart cell preparation station which correctly orients the cell, applies solder paste and forms and positions the correct lengths of interconnect lead. The system is controlled and monitored by a TRS-80 micro computer. The first operational tests of the fully integrated station have been run. These tests proved the soundness of the basic design concept but also pointed to areas in which modifications are necessary. These modifications are nearly complete and the improved parts are being integrated. Development of the controlling computer program is progressing to both reflect these changes and reduce operating time.

  5. Horizon: The Portable, Scalable, and Reusable Framework for Developing Automated Data Management and Product Generation Systems

    NASA Astrophysics Data System (ADS)

    Huang, T.; Alarcon, C.; Quach, N. T.

    2014-12-01

    Capture, curate, and analysis are the typical activities performed at any given Earth Science data center. Modern data management systems must be adaptable to heterogeneous science data formats, scalable to meet the mission's quality of service requirements, and able to manage the life-cycle of any given science data product. Designing a scalable data management doesn't happen overnight. It takes countless hours of refining, refactoring, retesting, and re-architecting. The Horizon data management and workflow framework, developed at the Jet Propulsion Laboratory, is a portable, scalable, and reusable framework for developing high-performance data management and product generation workflow systems to automate data capturing, data curation, and data analysis activities. The NASA's Physical Oceanography Distributed Active Archive Center (PO.DAAC)'s Data Management and Archive System (DMAS) is its core data infrastructure that handles capturing and distribution of hundreds of thousands of satellite observations each day around the clock. DMAS is an application of the Horizon framework. The NASA Global Imagery Browse Services (GIBS) is NASA's Earth Observing System Data and Information System (EOSDIS)'s solution for making high-resolution global imageries available to the science communities. The Imagery Exchange (TIE), an application of the Horizon framework, is a core subsystem for GIBS responsible for data capturing and imagery generation automation to support the EOSDIS' 12 distributed active archive centers and 17 Science Investigator-led Processing Systems (SIPS). This presentation discusses our ongoing effort in refining, refactoring, retesting, and re-architecting the Horizon framework to enable data-intensive science and its applications.

  6. Comparison of automated method and improved AOAC Kjeldahl method for determination of protein in meat and meat products.

    PubMed

    McGill, D L

    1981-01-01

    The Kjel-Foss automated method for protein determination meat and meat products was compared with the improved AOAC Kjeldahl method. Meat samples were separated into 3 categories based on fat content and analyzed in duplicate by both methods. No significant difference was found in a paired comparison of the 2 methods in each of the 3 meat categories, using Student's t-test at the 99% confidence level. A number of additional meat samples analyzed 6-9 times by the automated method showed an overall average range of 0.55% protein and average standard deviation of 0.20. The Kjel-Foss automated method was applicable for total protein determination in a wide variety of meat and meat products.

  7. 16 CFR 303.22 - Products containing linings, interlinings, fillings, and paddings.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... UNDER SPECIFIC ACTS OF CONGRESS RULES AND REGULATIONS UNDER THE TEXTILE FIBER PRODUCTS IDENTIFICATION... required information as to textile fiber products, the fiber content of any linings, interlinings,...

  8. CONTROL OF LASER RADIATION PARAMETERS: Automated tuning of a CO2 laser to a required oscillation line without a spectral instrument

    NASA Astrophysics Data System (ADS)

    Petukhov, V. O.; Gorobets, V. A.

    2005-02-01

    The method is proposed for tuning CO2 laser to a required oscillation line without a spectral instrument based on the coincidence of transition frequencies belonging to different vibrational—rotational bands of the CO2 molecule. This coincidence leads to the anomaly in the gain distribution over rotational sublevels, thereby affecting the laser output parameters. The method was successfully applied to a completely automated low-pressure, longitudinal-discharge cw CO2 laser and a pulsed TEA CO2 laser.

  9. 40 CFR 1051.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: (1) Describe any facility used to test production-line vehicles or engines and state its location. (2... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM RECREATIONAL ENGINES AND VEHICLES Testing Production-Line Vehicles and Engines § 1051.345 What production-line testing records must I send to EPA?...

  10. 40 CFR 1051.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...: (1) Describe any facility used to test production-line vehicles or engines and state its location. (2... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM RECREATIONAL ENGINES AND VEHICLES Testing Production-Line Vehicles and Engines § 1051.345 What production-line testing records must I send to EPA?...

  11. 40 CFR 1045.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: (1) Describe any facility used to test production-line engines and state its location. (2) State the... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.345 What production-line testing records must I send to...

  12. 40 CFR 1048.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... information: (1) Describe any facility used to test production-line engines and state its location. (2) State... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, LARGE NONROAD SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.345 What production-line testing records must I send to EPA?...

  13. 40 CFR 1048.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... information: (1) Describe any facility used to test production-line engines and state its location. (2) State... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, LARGE NONROAD SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.345 What production-line testing records must I send to EPA?...

  14. 16 CFR 303.22 - Products containing linings, interlinings, fillings, and paddings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Products containing linings, interlinings... ACT § 303.22 Products containing linings, interlinings, fillings, and paddings. In disclosing the required information as to textile fiber products, the fiber content of any linings, interlinings,...

  15. 9 CFR 113.52 - Requirements for cell lines used for production of biologics.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Requirements for cell lines used for... STANDARD REQUIREMENTS Ingredient Requirements § 113.52 Requirements for cell lines used for production of... cell line used to prepare a biological product shall be tested as prescribed in this section. A...

  16. 9 CFR 113.52 - Requirements for cell lines used for production of biologics.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Requirements for cell lines used for... STANDARD REQUIREMENTS Ingredient Requirements § 113.52 Requirements for cell lines used for production of... cell line used to prepare a biological product shall be tested as prescribed in this section. A...

  17. 9 CFR 113.52 - Requirements for cell lines used for production of biologics.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Requirements for cell lines used for... STANDARD REQUIREMENTS Ingredient Requirements § 113.52 Requirements for cell lines used for production of... cell line used to prepare a biological product shall be tested as prescribed in this section. A...

  18. 77 FR 14729 - Certain Lined Paper Products From India: Notice of Final Results of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... International Trade Administration Certain Lined Paper Products From India: Notice of Final Results of... lined paper products from India (CLPP).\\1\\ This review covers 35 manufacturers and exporters of the... Certain Lined Paper Products From India: Notice of Preliminary Results of Antidumping Duty...

  19. 78 FR 22845 - Certain Lined Paper Products From India: Final Results of Countervailing Duty Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-17

    ... International Trade Administration Certain Lined Paper Products From India: Final Results of Countervailing Duty... countervailing duty (CVD) order on certain lined paper products from India for the January 1, 2010, through...'' section. \\1\\ See Certain Lined Paper Products From India: Preliminary Results of Countervailing...

  20. 9 CFR 113.52 - Requirements for cell lines used for production of biologics.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Requirements for cell lines used for... STANDARD REQUIREMENTS Ingredient Requirements § 113.52 Requirements for cell lines used for production of... cell line used to prepare a biological product shall be tested as prescribed in this section. A...

  1. 9 CFR 113.52 - Requirements for cell lines used for production of biologics.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Requirements for cell lines used for... STANDARD REQUIREMENTS Ingredient Requirements § 113.52 Requirements for cell lines used for production of... cell line used to prepare a biological product shall be tested as prescribed in this section. A...

  2. 40 CFR 94.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Compliance with criteria for production line testing. 94.510 Section 94.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Manufacturer Production Line Testing Programs § 94.510 Compliance with criteria for production line testing....

  3. 40 CFR 91.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Compliance with criteria for production line testing. 91.510 Section 91.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Production Line Testing Program § 91.510 Compliance with criteria for production line testing. (a) A...

  4. 40 CFR 91.503 - Production line testing by the manufacturer.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Production line testing by the... PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Manufacturer Production Line Testing Program § 91.503 Production line testing by the manufacturer. (a) Manufacturers of marine...

  5. 40 CFR 91.503 - Production line testing by the manufacturer.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Production line testing by the... PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Manufacturer Production Line Testing Program § 91.503 Production line testing by the manufacturer. (a) Manufacturers of marine...

  6. 40 CFR 94.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Compliance with criteria for production line testing. 94.510 Section 94.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Manufacturer Production Line Testing Programs § 94.510 Compliance with criteria for production line testing....

  7. 40 CFR 1033.330 - Compliance criteria for production line testing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Production Line Testing and Audit Programs § 1033.330 Compliance criteria for production line testing. There... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Compliance criteria for production line testing. 1033.330 Section 1033.330 Protection of Environment ENVIRONMENTAL PROTECTION...

  8. 40 CFR 1033.330 - Compliance criteria for production line testing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Production Line Testing and Audit Programs § 1033.330 Compliance criteria for production line testing. There... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Compliance criteria for production line testing. 1033.330 Section 1033.330 Protection of Environment ENVIRONMENTAL PROTECTION...

  9. 40 CFR 92.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... production line testing. 92.510 Section 92.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Manufacturer and Remanufacturer Production Line Testing and Audit Programs § 92.510 Compliance with criteria for production line testing. (a) A failed locomotive or locomotive engine is one whose final...

  10. 40 CFR 92.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... production line testing. 92.510 Section 92.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Manufacturer and Remanufacturer Production Line Testing and Audit Programs § 92.510 Compliance with criteria for production line testing. (a) A failed locomotive or locomotive engine is one whose final...

  11. 40 CFR 91.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Production Line Testing Program § 91.510 Compliance with criteria for production line testing. (a) A failed... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Compliance with criteria for production line testing. 91.510 Section 91.510 Protection of Environment ENVIRONMENTAL PROTECTION...

  12. 40 CFR 91.503 - Production line testing by the manufacturer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Production line testing by the... PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Manufacturer Production Line Testing Program § 91.503 Production line testing by the manufacturer. (a) Manufacturers of marine...

  13. 40 CFR 92.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... production line testing. 92.510 Section 92.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Manufacturer and Remanufacturer Production Line Testing and Audit Programs § 92.510 Compliance with criteria for production line testing. (a) A failed locomotive or locomotive engine is one whose final...

  14. 40 CFR 91.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Compliance with criteria for production line testing. 91.510 Section 91.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Production Line Testing Program § 91.510 Compliance with criteria for production line testing. (a) A...

  15. 40 CFR 94.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Manufacturer Production Line Testing Programs § 94.510 Compliance with criteria for production line testing. (a... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Compliance with criteria for production line testing. 94.510 Section 94.510 Protection of Environment ENVIRONMENTAL PROTECTION...

  16. 40 CFR 91.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Compliance with criteria for production line testing. 91.510 Section 91.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Production Line Testing Program § 91.510 Compliance with criteria for production line testing. (a) A...

  17. 40 CFR 94.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Compliance with criteria for production line testing. 94.510 Section 94.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Manufacturer Production Line Testing Programs § 94.510 Compliance with criteria for production line testing....

  18. 40 CFR 1033.330 - Compliance criteria for production line testing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Production Line Testing and Audit Programs § 1033.330 Compliance criteria for production line testing. There... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Compliance criteria for production line testing. 1033.330 Section 1033.330 Protection of Environment ENVIRONMENTAL PROTECTION...

  19. 40 CFR 91.503 - Production line testing by the manufacturer.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Production line testing by the... PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Manufacturer Production Line Testing Program § 91.503 Production line testing by the manufacturer. (a) Manufacturers of marine...

  20. 40 CFR 1033.330 - Compliance criteria for production line testing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Production Line Testing and Audit Programs § 1033.330 Compliance criteria for production line testing. There... 40 Protection of Environment 33 2014-07-01 2014-07-01 false Compliance criteria for production line testing. 1033.330 Section 1033.330 Protection of Environment ENVIRONMENTAL PROTECTION...

  1. 40 CFR 92.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... production line testing. 92.510 Section 92.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Manufacturer and Remanufacturer Production Line Testing and Audit Programs § 92.510 Compliance with criteria for production line testing. (a) A failed locomotive or locomotive engine is one whose final...

  2. 40 CFR 91.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Compliance with criteria for production line testing. 91.510 Section 91.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Production Line Testing Program § 91.510 Compliance with criteria for production line testing. (a) A...

  3. 40 CFR 94.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Compliance with criteria for production line testing. 94.510 Section 94.510 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Manufacturer Production Line Testing Programs § 94.510 Compliance with criteria for production line testing....

  4. 40 CFR 91.503 - Production line testing by the manufacturer.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Production line testing by the... PROGRAMS (CONTINUED) CONTROL OF EMISSIONS FROM MARINE SPARK-IGNITION ENGINES Manufacturer Production Line Testing Program § 91.503 Production line testing by the manufacturer. (a) Manufacturers of marine...

  5. 40 CFR 1033.330 - Compliance criteria for production line testing.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Production Line Testing and Audit Programs § 1033.330 Compliance criteria for production line testing. There... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Compliance criteria for production line testing. 1033.330 Section 1033.330 Protection of Environment ENVIRONMENTAL PROTECTION...

  6. Laser light-section sensor automating the production of textile-reinforced composites

    NASA Astrophysics Data System (ADS)

    Schmitt, R.; Niggemann, C.; Mersmann, C.

    2009-05-01

    Due to their advanced weight-specific mechanical properties, the application of fibre-reinforced plastics (FRP) has been established as a key technology in several engineering areas. Textile-based reinforcement structures (Preform) in particular achieve a high structural integrity due to the multi-dimensional build-up of dry-fibre layers combined with 3D-sewing and further textile processes. The final composite parts provide enhanced damage tolerances through excellent crash-energy absorbing characteristics. For these reasons, structural parts (e.g. frame) will be integrated in next generation airplanes. However, many manufacturing processes for FRP are still involving manual production steps without integrated quality control. The non-automated production implies considerable process dispersion and a high rework rate. Before the final inspection there is no reliable information about the production status. This work sets metrology as the key to automation and thus an economically feasible production, applying a laser light-section sensor system (LLSS) to measure process quality and feed back the results to close control loops of the production system. The developed method derives 3D-measurements from height profiles acquired by the LLSS. To assure the textile's quality a full surface scan is conducted, detecting defects or misalignment by comparing the measurement results with a CAD model of the lay-up. The method focuses on signal processing of the height profiles to ensure a sub-pixel accuracy using a novel algorithm based on a non-linear least-square fitting to a set of sigmoid functions. To compare the measured surface points to the CAD model, material characteristics are incorporated into the method. This ensures that only the fibre layer of the textile's surface is included and gaps between the fibres or overlaying seams are neglected. Finally, determining the uncertainty in measurement according to the GUM-standard proofed the sensor system's accuracy

  7. Automated High-Content Assay for Compounds Selectively Toxic to Trypanosoma cruzi in a Myoblastic Cell Line

    PubMed Central

    Alonso-Padilla, Julio; Cotillo, Ignacio; Presa, Jesús L.; Cantizani, Juan; Peña, Imanol; Bardera, Ana I.; Martín, Jose J.; Rodriguez, Ana

    2015-01-01

    Background Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, represents a very important public health problem in Latin America where it is endemic. Although mostly asymptomatic at its initial stage, after the disease becomes chronic, about a third of the infected patients progress to a potentially fatal outcome due to severe damage of heart and gut tissues. There is an urgent need for new drugs against Chagas disease since there are only two drugs available, benznidazole and nifurtimox, and both show toxic side effects and variable efficacy against the chronic stage of the disease. Methodology/Principal Findings Genetically engineered parasitic strains are used for high throughput screening (HTS) of large chemical collections in the search for new anti-parasitic compounds. These assays, although successful, are limited to reporter transgenic parasites and do not cover the wide T. cruzi genetic background. With the aim to contribute to the early drug discovery process against Chagas disease we have developed an automated image-based 384-well plate HTS assay for T. cruzi amastigote replication in a rat myoblast host cell line. An image analysis script was designed to inform on three outputs: total number of host cells, ratio of T. cruzi amastigotes per cell and percentage of infected cells, which respectively provides one host cell toxicity and two T. cruzi toxicity readouts. The assay was statistically robust (Z´ values >0.6) and was validated against a series of known anti-trypanosomatid drugs. Conclusions/Significance We have established a highly reproducible, high content HTS assay for screening of chemical compounds against T. cruzi infection of myoblasts that is amenable for use with any T. cruzi strain capable of in vitro infection. Our visual assay informs on both anti-parasitic and host cell toxicity readouts in a single experiment, allowing the direct identification of compounds selectively targeted to the parasite. PMID:25615687

  8. Automation pilot

    NASA Technical Reports Server (NTRS)

    1983-01-01

    An important concept of the Action Information Management System (AIMS) approach is to evaluate office automation technology in the context of hands on use by technical program managers in the conduct of human acceptance difficulties which may accompany the transition to a significantly changing work environment. The improved productivity and communications which result from application of office automation technology are already well established for general office environments, but benefits unique to NASA are anticipated and these will be explored in detail.

  9. Improving GPR Surveys Productivity by Array Technology and Fully Automated Processing

    NASA Astrophysics Data System (ADS)

    Morello, Marco; Ercoli, Emanuele; Mazzucchelli, Paolo; Cottino, Edoardo

    2016-04-01

    The realization of network infrastructures with lower environmental impact and the tendency to use digging technologies less invasive in terms of time and space of road occupation and restoration play a key-role in the development of communication networks. However, pre-existing buried utilities must be detected and located in the subsurface, to exploit the high productivity of modern digging apparatus. According to SUE quality level B+ both position and depth of subsurface utilities must be accurately estimated, demanding for 3D GPR surveys. In fact, the advantages of 3D GPR acquisitions (obtained either by multiple 2D recordings or by an antenna array) versus 2D acquisitions are well-known. Nonetheless, the amount of acquired data for such 3D acquisitions does not usually allow to complete processing and interpretation directly in field and in real-time, thus limiting the overall efficiency of the GPR acquisition. As an example, the "low impact mini-trench "technique (addressed in ITU - International Telecommunication Union - L.83 recommendation) requires that non-destructive mapping of buried services enhances its productivity to match the improvements of new digging equipment. Nowadays multi-antenna and multi-pass GPR acquisitions demand for new processing techniques that can obtain high quality subsurface images, taking full advantage of 3D data: the development of a fully automated and real-time 3D GPR processing system plays a key-role in overall optical network deployment profitability. Furthermore, currently available computing power suggests the feasibility of processing schemes that incorporate better focusing algorithms. A novel processing scheme, whose goal is the automated processing and detection of buried targets that can be applied in real-time to 3D GPR array systems, has been developed and fruitfully tested with two different GPR arrays (16 antennas, 900 MHz central frequency, and 34 antennas, 600 MHz central frequency). The proposed processing

  10. Systems, methods and apparatus for developing and maintaining evolving systems with software product lines

    NASA Technical Reports Server (NTRS)

    Hinchey, Michael G. (Inventor); Rash, James L. (Inventor); Pena, Joaquin (Inventor)

    2011-01-01

    Systems, methods and apparatus are provided through which an evolutionary system is managed and viewed as a software product line. In some embodiments, the core architecture is a relatively unchanging part of the system, and each version of the system is viewed as a product from the product line. Each software product is generated from the core architecture with some agent-based additions. The result may be a multi-agent system software product line.

  11. AUTOMATED ANALYSIS OF AQUEOUS SAMPLES CONTAINING PESTICIDES, ACIDIC/BASIC/NEUTRAL SEMIVOLATILES AND VOLATILE ORGANIC COMPOUNDS BY SOLID PHASE EXTRACTION COUPLED IN-LINE TO LARGE VOLUME INJECTION GC/MS

    EPA Science Inventory

    Data is presented on the development of a new automated system combining solid phase extraction (SPE) with GC/MS spectrometry for the single-run analysis of water samples containing a broad range of organic compounds. The system uses commercially available automated in-line 10-m...

  12. NOAA NESDIS global automated satellite-based snow mapping system and products

    NASA Astrophysics Data System (ADS)

    Romanov, Peter

    2016-05-01

    Accurate, timely and spatially detailed information on the snow cover distribution and on the snow pack properties is needed in various research and practical applications including numerical weather prediction, climate modeling, river runoff estimates and flood forecasts. Owing to the wide area coverage, high spatial resolution and short repeat cycle of observations satellites present one of the key components of the global snow and ice cover monitoring system. The Global Multisensor Automated Snow and Ice Mapping System (GMASI) has been developed at the request of NOAA National Weather Service (NWS) and NOAA National Ice Center (NIC) to facilitate NOAA operational monitoring of snow and ice cover and to provide information on snow and ice for use in NWP models. Since 2006 the system has been routinely generating daily snow and ice cover maps using combined observations in the visible/infrared and in the microwave from operational meteorological satellites. The output product provides continuous (gap free) characterization of the global snow and ice cover distribution at 4 km spatial resolution. The paper presents a basic description of the snow and ice mapping algorithms incorporated in the system as well as of the product generated with GMASI. It explains the approach used to validate the derived snow and ice maps and provides the results of their accuracy assessment.

  13. Automated Data Production For A Novel Airborne Multiangle Spectropolarimetric Imager (AIRMSPI)

    NASA Technical Reports Server (NTRS)

    Jovanovic, V .M.; Bull, M.; Diner, D. J.; Geier, S.; Rheingans, B.

    2012-01-01

    A novel polarimetric imaging technique making use of rapid retardance modulation has been developed by JPL as a part of NASA's Instrument Incubator Program. It has been built into the Airborne Multiangle SpectroPolarimetric Imager (AirMSPI) under NASA's Airborne Instrument Technology Transition Program, and is aimed primarily at remote sensing of the amounts and microphysical properties of aerosols and clouds. AirMSPI includes an 8-band (355, 380, 445, 470, 555, 660, 865, 935 nm) pushbroom camera that measures polarization in a subset of the bands (470, 660, and 865 nm). The camera is mounted on a gimbal and acquires imagery in a configurable set of along-track viewing angles ranging between +67 deg and -67 deg relative to nadir. As a result, near simultaneous multi-angle, multi-spectral, and polarimetric measurements of the targeted areas at a spatial resolution ranging from 7 m to 20 m (depending on the viewing angle) can be derived. An automated data production system is being built to support high data acquisition rate in concert with co-registration and orthorectified mapping requirements. To date, a number of successful engineering checkout flights were conducted in October 2010, August-September 2011, and January 2012. Data products resulting from these flights will be presented.

  14. Managing the Evolution of an Enterprise Architecture using a MAS-Product-Line Approach

    NASA Technical Reports Server (NTRS)

    Pena, Joaquin; Hinchey, Michael G.; Resinas, manuel; Sterritt, Roy; Rash, James L.

    2006-01-01

    We view an evolutionary system ns being n software product line. The core architecture is the unchanging part of the system, and each version of the system may be viewed as a product from the product line. Each "product" may be described as the core architecture with sonre agent-based additions. The result is a multiagent system software product line. We describe an approach to such n Software Product Line-based approach using the MaCMAS Agent-Oriented nzethoclology. The approach scales to enterprise nrchitectures as a multiagent system is an approprinre means of representing a changing enterprise nrchitectclre nnd the inferaction between components in it.

  15. Automated sample preparation based on the sequential injection principle. Solid-phase extraction on a molecularly imprinted polymer coupled on-line to high-performance liquid chromatography.

    PubMed

    Theodoridis, Georgios; Zacharis, Constantinos K; Tzanavaras, Paraskevas D; Themelis, Demetrius G; Economou, Anastasios

    2004-03-19

    A molecularly imprinted polymer (MIP) prepared using caffeine, as a template, was validated as a selective sorbent for solid-phase extraction (SPE), within an automated on-line sample preparation method. The polymer produced was packed in a polypropylene cartridge, which was incorporated in a flow system prior to the HPLC analytical instrumentation. The principle of sequential injection was utilised for a rapid automated and efficient SPE procedure on the MIP. Samples, buffers, washing and elution solvents were introduced to the extraction cartridge via a peristaltic pump and a multi-position valve, both controlled by appropriate software developed in-house. The method was optimised in terms of flow rates, extraction time and volume. After extraction, the final eluent from the extraction cartridge was directed to the injection loop and was subsequently analysed on HPLC. The overall set-up facilitated unattended operation, operation and improved both mixing fluidics and method development flexibility. This system may be readily built in the laboratory and can be further used as an automated platform for on-line sample preparation.

  16. A flexible 3D vision system based on structured light for in-line product inspection

    NASA Astrophysics Data System (ADS)

    Skotheim, Øystein; Nygaard, Jens Olav; Thielemann, Jens; Vollset, Thor

    2008-02-01

    A flexible and highly configurable 3D vision system targeted for in-line product inspection is presented. The system includes a low cost 3D camera based on structured light and a set of flexible software tools that automate the measurement process. The specification of the measurement tasks is done in a first manual step. The user selects regions of the point cloud to analyze and specifies primitives to be characterized within these regions. After all measurement tasks have been specified, measurements can be carried out on successive parts automatically and without supervision. As a test case, a measurement cell for inspection of a V-shaped car component has been developed. The car component consists of two steel tubes attached to a central hub. Each of the tubes has an additional bushing clamped to its end. A measurement is performed in a few seconds and results in an ordered point cloud with 1.2 million points. The software is configured to fit cylinders to each of the steel tubes as well as to the inside of the bushings of the car part. The size, position and orientation of the fitted cylinders allow us to measure and verify a series of dimensions specified on the CAD drawing of the component with sub-millimetre accuracy.

  17. 78 FR 62584 - Certain Lined Paper Products From India: Preliminary Results of Countervailing Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-22

    ... International Trade Administration Certain Lined Paper Products From India: Preliminary Results of... administrative review of the countervailing duty (CVD) order on certain lined paper products from India. The...., Washington, DC 20230; telephone (202) 482-1503. Scope of the Order The merchandise subject to the Lined...

  18. 77 FR 61381 - Certain Lined Paper Products From India: Antidumping Duty Administrative Review; 2010-2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... International Trade Administration Certain Lined Paper Products From India: Antidumping Duty Administrative... Department) is conducting an administrative review of the antidumping duty order on certain lined paper..., respectively. Scope of the Order The merchandise covered by this order is certain lined paper products....

  19. 77 FR 53174 - Certain Lined Paper Products From Indonesia: Revocation of Antidumping and Countervailing Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... International Trade Administration Certain Lined Paper Products From Indonesia: Revocation of Antidumping and... revocation of the antidumping duty (AD) and countervailing duty (CVD) orders on certain lined paper products (lined paper) from Indonesia would not be likely to lead to the continuation or recurrence of...

  20. An automated method for measurement of methoxetamine in human plasma by use of turbulent flow on-line extraction coupled with liquid chromatography and mass spectrometric detection.

    PubMed

    Abe, Emuri; Ricard, Florian; Darrouzain, François; Alvarez, Jean Claude

    2013-01-01

    Methoxetamine is a new ketamine derivative designer drug which has recently become available via the Internet marketed as "legal ketamine". It is a new dissociative recreational drug, acting as an NMDA receptor antagonist and dopamine reuptake inhibitor. The objective of this study was to develop on-line automated sample preparation using a TurboFlow device coupled with liquid chromatography with ion-trap mass spectrometric detection for measurement of methoxetamine in human plasma. Samples (100 μL) were vortex mixed with internal standard solution (ketamine-d4 in acetonitrile). After centrifugation, 20 μL of the supernatant was injected on to a 50 mm × 0.5-mm C18XL Turboflow column. The retained analytes were then back-flushed on to a 50 mm × 3-mm (3 μm) Hypersil Gold analytical column for chromatographic separation, then eluted with a formate buffer-acetonitrile gradient. Methoxetamine and the IS were ionized by electrospray in positive mode. Parent [M + H](+) ions were m/z 248.1 for methoxetamine and m/z 242.0 for the IS. The most intense product ions from methoxetamine (m/z 203.0) and the IS (m/z 224.0) were used for quantification. The assay was accurate (96.8-108.8% range) and precise (intra and inter-day coefficients of variation <8.8%) over the range of 2.0 (lower limit of quantification) to 1000.0 ng mL(-1) (upper limit of quantification). No matrix effect was observed. This method has been successfully applied to determination of plasma concentrations of methoxetamine in the first French hospitalization case report after acute intoxication; the plasma concentration was 136 ng mL(-1).

  1. Automated determination of phenylcarbamate herbicides in environmental waters by on-line trace enrichment and reversed-phase liquid chromatography-diode array detection.

    PubMed

    Hidalgo, C; Sancho, J V; López, F J; Hernández, F

    1998-10-09

    A fully automated liquid chromatographic method using on-line trace-enrichment, gradient elution and diode array detection is described for the trace-level determination of several phenylcarbamate herbicides, such as carbetamide, propham, desmedipham, phenmedipham, chlorbufam and chlorpropham, in environmental water samples. In this work, two different enrichment pre-columns have been assayed, a 5.8 x 4.6 mm I.D., 10 microns ODS Prelute cartridge and a 10 x 2 mm I.D. cartridge filled with 10 microns PRP-1 polymer, both coupled to a 150 x 4.6 mm I.D. analytical column filled with 5 microns ODS. Using the C18 pre-column, up to 50 ml of water sample could be percolated without peak broadening of any compound. However, a lack of reproducibility was observed in the case of carbetamide, the most polar analyte, after performing recovery experiments by percolating drinking and surface water samples spiked at several levels (0.5 and 4 micrograms l-1). On the other hand, the PRP-1 pre-column allowed the enrichment up to 100 ml of water sample with satisfactory results for every compound, including carbetamide. The procedure was validated by recovery experiments in environmental water samples spiked at 0.2 and 1 microgram l-1 yielding average recoveries between 84-108% with relative standard deviations in the range 2-12%. Detection limits as low as 0.04 microgram l-1 were achieved. It was observed that desmedipham and phenmedipham degraded rapidly in the environmental water samples as showed the degradation studies performed along 24 h in drinking and surface waters spiked at 4 micrograms l-1. Although the standard mixture, prepared in HPLC water, was stable for around one week, in the environmental water matrices more than 95% of each herbicide degraded after 6 h, and new chromatographic peaks corresponding to the degradation products were detected.

  2. Neural networks are paying off on the production line

    SciTech Connect

    Irving, B.

    1997-10-01

    One very small company is working overtime on a technology called neural networks and is bringing this technology onto the production lines of some of the largest manufacturers in the world. The innovator here is Native American Technologies Co., Golden, Colo. Jerry Jones, the company`s chief scientist, explained the reason for this great interest in neural networks. A former member of the faculty at Colorado School of Mines, Jones said the large manufacturers want robust operating conditions. They want to be able to understand their processes well enough so that they don`t have to have fixtures on their shop floors. Fixtures are expensive to buy and to maintain and they have been known to die on the shop floor. Industry wants software capable of searching for those most robust operating conditions. N.A. Technologies is working closely with the Colorado School of Mines and with AMET, Inc., Rexford, Idaho, on projects in arc welding, friction stir welding, resistance welding, laser beam welding and electron beam welding. All of these projects are using exactly the same architecture and the same software, so the cost of development is spread out over a wide number of projects and a large number of potential applications. The end result is that the cost for any one given process is significantly less than it would be by any other approach.

  3. Automation of the longwall mining system

    NASA Technical Reports Server (NTRS)

    Zimmerman, W.; Aster, R. W.; Harris, J.; High, J.

    1982-01-01

    Cost effective, safe, and technologically sound applications of automation technology to underground coal mining were identified. The longwall analysis commenced with a general search for government and industry experience of mining automation technology. A brief industry survey was conducted to identify longwall operational, safety, and design problems. The prime automation candidates resulting from the industry experience and survey were: (1) the shearer operation, (2) shield and conveyor pan line advance, (3) a management information system to allow improved mine logistics support, and (4) component fault isolation and diagnostics to reduce untimely maintenance delays. A system network analysis indicated that a 40% improvement in productivity was feasible if system delays associated with all of the above four areas were removed. A technology assessment and conceptual system design of each of the four automation candidate areas showed that state of the art digital computer, servomechanism, and actuator technologies could be applied to automate the longwall system.

  4. A first-generation software product line for data acquisition systems in astronomy

    NASA Astrophysics Data System (ADS)

    López-Ruiz, J. C.; Heradio, Rubén; Cerrada Somolinos, José Antonio; Coz Fernandez, José Ramón; López Ramos, Pablo

    2008-07-01

    This article presents a case study on developing a software product line for data acquisition systems in astronomy based on the Exemplar Driven Development methodology and the Exemplar Flexibilization Language tool. The main strategies to build the software product line are based on the domain commonality and variability, the incremental scope and the use of existing artifacts. It consists on a lean methodology with little impact on the organization, suitable for small projects, which reduces product line start-up time. Software Product Lines focuses on creating a family of products instead of individual products. This approach has spectacular benefits on reducing the time to market, maintaining the know-how, reducing the development costs and increasing the quality of new products. The maintenance of the products is also enhanced since all the data acquisition systems share the same product line architecture.

  5. Computer-Assisted System to Automate Production of Posterior Dental Restorations

    NASA Astrophysics Data System (ADS)

    Rekow, E. Dianne; Erdman, Arthur G.; Speidel, T. Michael

    1986-07-01

    The feasibility of a system which is capable of automating production of posterior dental restorations has been investigated. Data acquisition can be accomplished in a clinical setting using standard equipment to obtain stereoscopic views of the prepared tooth, adjacent and opposing teeth, and the jaw in motion. Data from the patient is digitized with a very high resolution digitizer. Stereophotogrammetric reconstruction and kinematic analysis establish the three-dimensional envelope in which the restoration must function. Ideal tooth profiles have been digitized for each of the fourteen unique teeth. Each tooth profile is represented by B-spline or Bezier curves and surfaces. Utilizing local influence properties of these curves and surfaces, the ideal profile can be modified to provide proper function and fill the available space, yielding a morphologically correct restor-ation which meets the unique design requirements for a specific patient. Spline curves and surfaces also ensure that the surfaces are well behaved, without discontinuities. This property facilitates generation of tool paths for numerically controlled machining. The latest version of Control Data Corporation's ICEM-DDN package, with its interface with the newly developed graphics programming language (GPL) is used to create those tool paths. Special consideration is given to unique requirements of mating internal and external sur-faces as well as to high precision, small size manufacturing.

  6. Iron K Lines from Accretion Disks: Models for Line Production and Spectroscopic Constraints

    NASA Technical Reports Server (NTRS)

    Kallman, Timothy; Palmeri, Patrick

    2004-01-01

    Measured profiles of the iron K lines provide important dynamical information about emitting matrial in compact objects. However, much of the modeling work which has been used to infer the location and origin of line observed from AGN and galactic black hole sources is based on highly simplified assumptions about the microphysics of K line emission. In particular, many of the intrinsic line energies, widths and emissivities are based on central-field atomic calculations. We present the results of new calculations of the quantities for the entire iron isonuclear sequence, and demonstrate that the intrinsic K line spectra contain considerably more complexity than has been previously considered. We also present calculations of iron K emission and absorption spectra which include the new data, including the local spectrum radiated from an X-ray illuminated accretion disk. The implications for the interpretation of observed iron K lines from black hole sources will be discussed.

  7. Technology modernization assessment flexible automation

    SciTech Connect

    Bennett, D.W.; Boyd, D.R.; Hansen, N.H.; Hansen, M.A.; Yount, J.A.

    1990-12-01

    The objectives of this report are: to present technology assessment guidelines to be considered in conjunction with defense regulations before an automation project is developed to give examples showing how assessment guidelines may be applied to a current project to present several potential areas where automation might be applied successfully in the depot system. Depots perform primarily repair and remanufacturing operations, with limited small batch manufacturing runs. While certain activities (such as Management Information Systems and warehousing) are directly applicable to either environment, the majority of applications will require combining existing and emerging technologies in different ways, with the special needs of depot remanufacturing environment. Industry generally enjoys the ability to make revisions to its product lines seasonally, followed by batch runs of thousands or more. Depot batch runs are in the tens, at best the hundreds, of parts with a potential for large variation in product mix; reconfiguration may be required on a week-to-week basis. This need for a higher degree of flexibility suggests a higher level of operator interaction, and, in turn, control systems that go beyond the state of the art for less flexible automation and industry in general. This report investigates the benefits and barriers to automation and concludes that, while significant benefits do exist for automation, depots must be prepared to carefully investigate the technical feasibility of each opportunity and the life-cycle costs associated with implementation. Implementation is suggested in two ways: (1) develop an implementation plan for automation technologies based on results of small demonstration automation projects; (2) use phased implementation for both these and later stage automation projects to allow major technical and administrative risk issues to be addressed. 10 refs., 2 figs., 2 tabs. (JF)

  8. 40 CFR 90.710 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 21 2013-07-01 2013-07-01 false Compliance with criteria for production line testing. 90.710 Section 90.710 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... KILOWATTS Manufacturer Production Line Testing Program § 90.710 Compliance with criteria for production...

  9. 40 CFR 90.710 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 21 2012-07-01 2012-07-01 false Compliance with criteria for production line testing. 90.710 Section 90.710 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... KILOWATTS Manufacturer Production Line Testing Program § 90.710 Compliance with criteria for production...

  10. 40 CFR 90.710 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 20 2011-07-01 2011-07-01 false Compliance with criteria for production line testing. 90.710 Section 90.710 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... KILOWATTS Manufacturer Production Line Testing Program § 90.710 Compliance with criteria for production...

  11. Integrated configurable equipment selection and line balancing for mass production with serial-parallel machining systems

    NASA Astrophysics Data System (ADS)

    Battaïa, Olga; Dolgui, Alexandre; Guschinsky, Nikolai; Levin, Genrikh

    2014-10-01

    Solving equipment selection and line balancing problems together allows better line configurations to be reached and avoids local optimal solutions. This article considers jointly these two decision problems for mass production lines with serial-parallel workplaces. This study was motivated by the design of production lines based on machines with rotary or mobile tables. Nevertheless, the results are more general and can be applied to assembly and production lines with similar structures. The designers' objectives and the constraints are studied in order to suggest a relevant mathematical model and an efficient optimization approach to solve it. A real case study is used to validate the model and the developed approach.

  12. Gamma ray line production from cosmic ray spallation reactions

    NASA Technical Reports Server (NTRS)

    Silberberg, R.; Tsao, C. H.; Letaw, J. R.

    1985-01-01

    The gamma ray line intensities due to cosmic ray spallation reactions in clouds, the galactic disk and accreting binary pulsars are calculated. With the most favorable plausible assumptions, only a few lines may be detectable to the level of 0.0000001 per sq. cm per sec. The intensities are compared with those generated in nuclear excitation reactions.

  13. One Year of ICTP Diploma Courses On-Line Using the Automated EyA Recording System

    ERIC Educational Resources Information Center

    Canessa, Enrique; Fonda, Carlo; Zennaro, Marco

    2009-01-01

    The 12-month pre-Ph.D. ICTP Diploma Courses in the fields of Condensed Matter Physics, High Energy Physics, Mathematics, Earth System Physics and Basics Physics have been recorded using the automated, low cost recording system called EyA developed in-house. We discuss the technical details on how these recordings were implemented, together with…

  14. Automated system for the on-line monitoring of powder blending processes using near-infrared spectroscopy. Part I. System development and control.

    PubMed

    Hailey, P A; Doherty, P; Tapsell, P; Oliver, T; Aldridge, P K

    1996-03-01

    An automated system for the on-line monitoring of powder blending processes is described. The system employs near-infrared (NIR) spectroscopy using fibre-optics and a graphical user interface (GUI) developed in the LabVIEW environment. The complete supervisory control and data analysis (SCADA) software controls blender and spectrophotometer operation and performs statistical spectral data analysis in real time. A data analysis routine using standard deviation is described to demonstrate an approach to the real-time determination of blend homogeneity.

  15. SAGA: A project to automate the management of software production systems

    NASA Technical Reports Server (NTRS)

    Campbell, Roy H.; Laliberte, D.; Render, H.; Sum, R.; Smith, W.; Terwilliger, R.

    1987-01-01

    The Software Automation, Generation and Administration (SAGA) project is investigating the design and construction of practical software engineering environments for developing and maintaining aerospace systems and applications software. The research includes the practical organization of the software lifecycle, configuration management, software requirements specifications, executable specifications, design methodologies, programming, verification, validation and testing, version control, maintenance, the reuse of software, software libraries, documentation, and automated management.

  16. Advanced oxidation protein products (AOPP) for monitoring oxidative stress in critically ill patients: a simple, fast and inexpensive automated technique.

    PubMed

    Selmeci, László; Seres, Leila; Antal, Magda; Lukács, Júlia; Regöly-Mérei, Andrea; Acsády, György

    2005-01-01

    Oxidative stress is known to be involved in many human pathological processes. Although there are numerous methods available for the assessment of oxidative stress, most of them are still not easily applicable in a routine clinical laboratory due to the complex methodology and/or lack of automation. In research into human oxidative stress, the simplification and automation of techniques represent a key issue from a laboratory point of view at present. In 1996 a novel oxidative stress biomarker, referred to as advanced oxidation protein products (AOPP), was detected in the plasma of chronic uremic patients. Here we describe in detail an automated version of the originally published microplate-based technique that we adapted for a Cobas Mira Plus clinical chemistry analyzer. AOPP reference values were measured in plasma samples from 266 apparently healthy volunteers (university students; 81 male and 185 female subjects) with a mean age of 21.3 years (range 18-33). Over a period of 18 months we determined AOPP concentrations in more than 300 patients in our department. Our experiences appear to demonstrate that this technique is especially suitable for monitoring oxidative stress in critically ill patients (sepsis, reperfusion injury, heart failure) even at daily intervals, since AOPP exhibited rapid responses in both directions. We believe that the well-established relationship between AOPP response and induced damage makes this simple, fast and inexpensive automated technique applicable in daily routine laboratory practice for assessing and monitoring oxidative stress in critically ill or other patients.

  17. Alicyclobacillus contamination in the production line of kiwi products in China.

    PubMed

    Zhang, Jiangbo; Yue, Tianli; Yuan, Yahong

    2013-01-01

    Alicyclobacillus are spoilage microbes of many juice products, but contamination of kiwi products by Alicyclobacillus is seldom reported. This study aims to investigate the whole production line of kiwi products in China to assess the potential risk of their contamination. A total of 401 samples from 18 commercial products, 1 processing plant and 16 raw material orchards were tested, and 76 samples were positive, from which 76 strains of microbes were isolated and identified as 4 species of Alicyclobacillus, including Alicyclobacillus acidoterrestris, Alicyclobacillus contaminans, Alicyclobacillus herbarius and Alicyclobacillus cycloheptanicus, and another 9 strains as 3 species of Bacillus by sequencing of their 16S rDNA. Through phylogenetic tree construction and RAPD-PCR amplification, it was found that there exist genotypic diversities to some extent among these isolates. Four test strains (each from one species of the 4 Alicyclobacillus species isolated in this study) could spoil pH adjusted kiwi fruit juice and some commercial kiwi fruit products with producing guaiacol (11-34 ppb).

  18. Automation in photogrammetry: Recent developments and applications (1972-1976)

    USGS Publications Warehouse

    Thompson, M.M.; Mikhail, E.M.

    1976-01-01

    An overview of recent developments in the automation of photogrammetry in various countries is presented. Conclusions regarding automated photogrammetry reached at the 1972 Congress in Ottawa are reviewed first as a background for examining the developments of 1972-1976. Applications are described for each country reporting significant developments. Among fifteen conclusions listed are statements concerning: the widespread practice of equipping existing stereoplotters with simple digitizers; the growing tendency to use minicomputers on-line with stereoplotters; the optimization of production of digital terrain models by progressive sampling in stereomodels; the potential of digitization of a photogrammetric model by density correlation on epipolar lines; the capabilities and economic aspects of advanced systems which permit simultaneous production of orthophotos, contours, and digital terrain models; the economy of off-line orthophoto systems; applications of digital image processing; automation by optical techniques; applications of sensors other than photographic imagery, and the role of photogrammetric phases in a completely automated cartographic system. ?? 1976.

  19. Automated power management and control

    NASA Technical Reports Server (NTRS)

    Dolce, James L.

    1991-01-01

    A comprehensive automation design is being developed for Space Station Freedom's electric power system. A joint effort between NASA's Office of Aeronautics and Exploration Technology and NASA's Office of Space Station Freedom, it strives to increase station productivity by applying expert systems and conventional algorithms to automate power system operation. The initial station operation will use ground-based dispatches to perform the necessary command and control tasks. These tasks constitute planning and decision-making activities that strive to eliminate unplanned outages. We perceive an opportunity to help these dispatchers make fast and consistent on-line decisions by automating three key tasks: failure detection and diagnosis, resource scheduling, and security analysis. Expert systems will be used for the diagnostics and for the security analysis; conventional algorithms will be used for the resource scheduling.

  20. 40 CFR 1051.305 - How must I prepare and test my production-line vehicles or engines?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... production-line vehicles or engines? 1051.305 Section 1051.305 Protection of Environment ENVIRONMENTAL... VEHICLES Testing Production-Line Vehicles and Engines § 1051.305 How must I prepare and test my production-line vehicles or engines? This section describes how to prepare and test production-line vehicles...

  1. 40 CFR 1051.305 - How must I prepare and test my production-line vehicles or engines?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... production-line vehicles or engines? 1051.305 Section 1051.305 Protection of Environment ENVIRONMENTAL... VEHICLES Testing Production-Line Vehicles and Engines § 1051.305 How must I prepare and test my production-line vehicles or engines? This section describes how to prepare and test production-line vehicles...

  2. 40 CFR 1051.305 - How must I prepare and test my production-line vehicles or engines?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... production-line vehicles or engines? 1051.305 Section 1051.305 Protection of Environment ENVIRONMENTAL... VEHICLES Testing Production-Line Vehicles and Engines § 1051.305 How must I prepare and test my production-line vehicles or engines? This section describes how to prepare and test production-line vehicles...

  3. 40 CFR 1051.305 - How must I prepare and test my production-line vehicles or engines?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... production-line vehicles or engines? 1051.305 Section 1051.305 Protection of Environment ENVIRONMENTAL... VEHICLES Testing Production-Line Vehicles and Engines § 1051.305 How must I prepare and test my production-line vehicles or engines? This section describes how to prepare and test production-line vehicles...

  4. 40 CFR 1051.305 - How must I prepare and test my production-line vehicles or engines?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... production-line vehicles or engines? 1051.305 Section 1051.305 Protection of Environment ENVIRONMENTAL... VEHICLES Testing Production-Line Vehicles and Engines § 1051.305 How must I prepare and test my production-line vehicles or engines? This section describes how to prepare and test production-line vehicles...

  5. An automated system to mount cryo-cooled protein crystals on a synchrotron beam line, using compact sample cassettes and a small-scale robot

    PubMed Central

    Cohen, Aina E.; Ellis, Paul J.; Miller, Mitchell D.; Deacon, Ashley M.; Phizackerley, R. Paul

    2014-01-01

    An automated system for mounting and dismounting pre-frozen crystals has been implemented at the Stanford Synchrotron Radiation Laboratory (SSRL). It is based on a small industrial robot and compact cylindrical cassettes, each holding up to 96 crystals mounted on Hampton Research sample pins. For easy shipping and storage, the cassette fits inside several popular dry-shippers and long-term storage Dewars. A dispensing Dewar holds up to three cassettes in liquid nitrogen adjacent to the beam line goniometer. The robot uses a permanent magnet tool to extract samples from, and insert samples into a cassette, and a cryo-tong tool to transfer them to and from the beam line goniometer. The system is simple, with few moving parts, reliable in operation and convenient to use. PMID:24899734

  6. Quantitative determination of opioids in whole blood using fully automated dried blood spot desorption coupled to on-line SPE-LC-MS/MS.

    PubMed

    Verplaetse, Ruth; Henion, Jack

    2016-01-01

    Opioids are well known, widely used painkillers. Increased stability of opioids in the dried blood spot (DBS) matrix compared to blood/plasma has been described. Other benefits provided by DBS techniques include point-of-care collection, less invasive micro sampling, more economical shipment, and convenient storage. Current methodology for analysis of micro whole blood samples for opioids is limited to the classical DBS workflow, including tedious manual punching of the DBS cards followed by extraction and liquid chromatography-tandem mass spectrometry (LC-MS/MS) bioanalysis. The goal of this study was to develop and validate a fully automated on-line sample preparation procedure for the analysis of DBS micro samples relevant to the detection of opioids in finger prick blood. To this end, automated flow-through elution of DBS cards was followed by on-line solid-phase extraction (SPE) and analysis by LC-MS/MS. Selective, sensitive, accurate, and reproducible quantitation of five representative opioids in human blood at sub-therapeutic, therapeutic, and toxic levels was achieved. The range of reliable response (R(2)  ≥0.997) was 1 to 500 ng/mL whole blood for morphine, codeine, oxycodone, hydrocodone; and 0.1 to 50 ng/mL for fentanyl. Inter-day, intra-day, and matrix inter-lot accuracy and precision was less than 15% (even at lower limits of quantitation (LLOQ) level). The method was successfully used to measure hydrocodone and its major metabolite norhydrocodone in incurred human samples. Our data support the enormous potential of DBS sampling and automated analysis for monitoring opioids as well as other pharmaceuticals in both anti-doping and pain management regimens.

  7. Drinking Water Disinfection by In-line Electrolysis: Product and Inorganic By-Product Formation

    NASA Astrophysics Data System (ADS)

    Bergmann, M. E. Henry

    This section covers peculiarities of so-called in-line electrolysis when drinking water is electrolysed to produce disinfection species killing microorganisms. Mainly mixed oxide electrodes (MIO) based on IrO2 and/or RuO2 coatings and boron-doped diamond electrodes were used in the studies. Artificial and real drinking water systems were electrolysed in continuous and discontinuous operating mode, varying water composition, current density and electrode materials. Results show, besides the ability of producing active chlorine, risks of inorganic disinfection by-products (DBPs) such as chlorate, perchlorate, nitrite, ammonium, chloramines, hydrogen peroxide and others. DBPs are responsible for analysis errors using DPD method for active chlorine measurements. Geometry may influence by-product yield. As a conclusion, the necessity of developing test routines for practical cell applications must be underlined.

  8. Investigation Of In-Line Monitoring Options At H Canyon/HB Line For Plutonium Oxide Production

    SciTech Connect

    Sexton, L.

    2015-10-14

    H Canyon and HB Line have a production goal of 1 MT per year of plutonium oxide feedstock for the MOX facility by FY17 (AFS-2 mission). In order to meet this goal, steps will need to be taken to improve processing efficiency. One concept for achieving this goal is to implement in-line process monitoring at key measurement points within the facilities. In-line monitoring during operations has the potential to increase throughput and efficiency while reducing costs associated with laboratory sample analysis. In the work reported here, we mapped the plutonium oxide process, identified key measurement points, investigated alternate technologies that could be used for in-line analysis, and initiated a throughput benefit analysis.

  9. 78 FR 13016 - Certain Lined Paper Products From India: Notice of Partial Rescission of Countervailing Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-26

    ... International Trade Administration Certain Lined Paper Products From India: Notice of Partial Rescission of... order on certain lined paper products from India.\\1\\ \\1\\ See Antidumping or Countervailing Duty Order... Paper Suppliers. \\4\\ See petitioners' November 27, 2012, Withdrawal of Request for Administrative...

  10. A Role-Playing Game for a Software Engineering Lab: Developing a Product Line

    ERIC Educational Resources Information Center

    Zuppiroli, Sara; Ciancarini, Paolo; Gabbrielli, Maurizio

    2012-01-01

    Software product line development refers to software engineering practices and techniques for creating families of similar software systems from a basic set of reusable components, called shared assets. Teaching how to deal with software product lines in a university lab course is a challenging task, because there are several practical issues that…

  11. 40 CFR 92.510 - Compliance with criteria for production line testing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Manufacturer and Remanufacturer Production Line Testing and Audit Programs § 92.510 Compliance with criteria for production line testing. (a) A failed locomotive or locomotive engine is one whose final test... 40 Protection of Environment 20 2014-07-01 2013-07-01 true Compliance with criteria for...

  12. Intelligent Production Monitoring and Control based on Three Main Modules for Automated Manufacturing Cells in the Automotive Industry

    NASA Astrophysics Data System (ADS)

    Berger, Ulrich; Kretzschmann, Ralf; Algebra, A. Vargas Veronica

    2008-06-01

    The automotive industry is distinguished by regionalization and customization of products. As consequence, the diversity of products will increase while the lot sizes will decrease. Thus, more product types will be handled along the process chain and common production paradigms will fail. Although Rapid Manufacturing (RM) methodology will be used for producing small individual lot sizes, new solution for joining and assembling these components are needed. On the other hand, the non-availability of existing operational knowledge and the absence of dynamic and explicit knowledge retrieval minimize the achievement of on-demand capabilities. Thus, in this paper, an approach for an Intelligent Production System will be introduced. The concept is based on three interlinked main modules: a Technology Data Catalogue (TDC) based on an ontology system, an Automated Scheduling Processor (ASP) based on graph theory and a central Programmable Automation Controller (PAC) for real-time sensor/actor communication. The concept is being implemented in a laboratory set-up with several assembly and joining processes and will be experimentally validated in some research and development projects.

  13. Development of trigger-based semi-automated surveillance of ventilator-associated pneumonia and central line-associated bloodstream infections in a Dutch intensive care

    PubMed Central

    2014-01-01

    Background Availability of a patient data management system (PDMS) has created the opportunity to develop trigger-based electronic surveillance systems (ESSs). The aim was to evaluate a semi-automated trigger-based ESS for the detection of ventilator-associated pneumonia (VAP) and central line-associated blood stream infections (CLABSIs) in the intensive care. Methods Prospective comparison of surveillance was based on a semi-automated ESS with and without trigger. Components of the VAP/CLABSI definition served as triggers. These included the use of VAP/CLABSI-related antibiotics, the presence of mechanical ventilation or an intravenous central line, and the presence of specific clinical symptoms. Triggers were automatically fired by the PDMS. Chest X-rays and microbiology culture results were checked only on patient days with a positive trigger signal from the ESS. In traditional screening, no triggers were used; therefore, chest X-rays and culture results had to be screened for all patient days of all included patients. Patients with pneumonia at admission were excluded. Results A total of 553 patients were screened for VAP and CLABSI. The incidence of VAP was 3.3/1,000 ventilation days (13 VAP/3,927 mechanical ventilation days), and the incidence of CLABSI was 1.7/1,000 central line days (24 CLABSI/13.887 central line days). For VAP, the trigger-based screening had a sensitivity of 92.3%, a specificity of 100%, and a negative predictive value of 99.8% compared to traditional screening of all patients. For CLABSI, sensitivity was 91.3%, specificity 100%, and negative predictive value 99.6%. Conclusions Pre-selection of patients to be checked for signs and symptoms of VAP and CLABSI by a computer-generated automated trigger system was time saving but slightly less accurate than conventional surveillance. However, this after-the-fact surveillance was mainly designed as a quality indicator over time rather than for precise determination of infection rates. Therefore

  14. Screening of over 100 drugs in horse urine using automated on-line solid-phase extraction coupled to liquid chromatography-high resolution mass spectrometry for doping control.

    PubMed

    Kwok, W H; Choi, Timmy L S; Tsoi, Yeuki Y K; Leung, Gary N W; Wan, Terence S M

    2017-02-14

    A fast method for the direct analysis of enzyme-hydrolysed horse urine using an automated on-line solid-phase extraction (SPE) coupled to a liquid-chromatography/high resolution mass spectrometer was developed. Over 100 drugs of diverse drug classes could be simultaneously detected in horse urine at sub to low parts per billion levels. Urine sample was first hydrolysed by β-glucuronidase to release conjugated drugs, followed by centrifugal filtration. The filtrate (1mL) was directly injected into an on-line SPE system consisting of a pre-column filter and a SPE cartridge column for the separation of analytes from matrix components. Through valves-switching, the interfering matrix components were flushed to waste, and the analytes were eluted to a C18 analytical column for refocusing and chromatographic separation. Detections were achieved by full-scan HRMS in alternating positive and negative electrospray ionisation modes within a turn-around time of 16min, inclusive of on-line sample clean-up and post-run mobile phase equilibration. No significant matrix interference was observed at the expected retention times of the targeted masses. Over 90% of the drugs studied gave estimated limits of detection (LoDs) at or below 5ng/mL, with some LoDs reaching down to 0.05ng/mL. Data-dependent acquisition (DDA) was included to provide additional product-ion scan data to substantiate the presence of detected analytes. The resulting product-ion spectra can be searched against an in-house MS/MS library for identity verification. The applicability of the method has been demonstrated by the detection of drugs in doping control samples.

  15. Validation and calibration of a TDLAS oxygen sensor for in-line measurement on flow-packed products

    NASA Astrophysics Data System (ADS)

    Cocola, L.; Fedel, M.; Allermann, H.; Landa, S.; Tondello, G.; Bardenstein, A.; Poletto, L.

    2016-05-01

    A device based on Tunable Diode Laser Absorption Spectroscopy has been developed for non-invasive evaluation of gaseous oxygen concentration inside packed food containers. This work has been done in the context of the SAFETYPACK European project in order to enable full, automated product testing on a production line. The chosen samples at the end of the manufacturing process are modified atmosphere bags of processed mozzarella, in which the target oxygen concentration is required to be below 5%. The spectrometer allows in-line measurement of moving samples which are passing on a conveyor belt, with an optical layout optimized for bags made of a flexible scattering material, and works by sensing the gas phase in the headspace at the top of the package. A field applicable method for the calibration of this device has been identified and validated against traditional, industry standard, invasive measurement techniques. This allows some degrees of freedom for the end-user regarding packaging dimensions and shape. After deployment and setup of the instrument at the end-user manufacturing site, performance has been evaluated on a different range of samples in order to validate the choice of electro optical and geometrical parameters regarding sample handling and measurement timing at the actual measurement conditions.

  16. Automated synthesis of transmission lines loaded with complementary split ring resonators (CSRRs) and open complementary split ring resonators (OCSRRs) through aggressive space mapping (ASM)

    NASA Astrophysics Data System (ADS)

    Selga, Jordi; Rodríguez, Ana; Orellana, Marco; Boria, Vicente; Martín, Ferran

    2014-09-01

    This paper is focused on the application of space mapping optimization to the automated synthesis of transmission lines loaded with complementary split ring resonators (CSRRs) and open complementary split ring resonators (OCSRRs). These structures are of interest for the implementation of resonant-type metamaterial transmission lines and for the design of planar microwave circuits based on such complementary resonators. The paper presents a method to generate the layouts of CSRR- and OCSRR-loaded microstrip lines from the elements of their equivalent circuit models. Using the so-called aggressive space mapping, a specific implementation that uses quasi-Newton type iteration, we have developed synthesis algorithms that are able to provide the topology of these CSRR- and OCSRR-loaded lines in few steps. The most relevant aspect, however, is that this synthesis process is completely automatic, i.e., it does not require any action from the designers, other than initiating the algorithm. Moreover, this technique can be translated to other electrically small planar elements described by lumped element equivalent circuit models.

  17. Introduction: Laboratory automation at Schering-Plough—increased productivity today and foundation for the future

    PubMed Central

    Zenie, Francis H.

    1995-01-01

    The following is the introductory presentation to the 1994 ISLAR meeting held in Boston from 16 to 19 October 1994. The Editor is again grateful to the organizer, the Zymark Corporation, for permission to publish the papers in the Managing Laboratory Automation Session read at ISLAR. PMID:18925010

  18. Line balancing and model sequencing to reduce work overload in mixed-model U-line production environments

    NASA Astrophysics Data System (ADS)

    Kara, Yakup

    2008-07-01

    Mixed-model U-lines (MMULs) are important elements of just-in-time production systems. For successful implementation of MMULs, a smoothed workload distribution among workstations is important. This requires that line balancing and model sequencing problems are solved simultaneously. This article presents a mixed, zero-one, nonlinear mathematical programming formulation for balancing and sequencing MMULs simultaneously with the objective of reducing work overload. Since the problem is NP-hard, an effective simulated annealing approach is also presented and its performance compared with existing approaches. The results show that the proposed simulated annealing algorithm outperforms existing approaches.

  19. A model for simulating the grinding and classification cyclic system of waste PCBs recycling production line.

    PubMed

    Yang, Deming; Xu, Zhenming

    2011-09-15

    Crushing and separating technology is widely used in waste printed circuit boards (PCBs) recycling process. A set of automatic line without negative impact to environment for recycling waste PCBs was applied in industry scale. Crushed waste PCBs particles grinding and classification cyclic system is the most important part of the automatic production line, and it decides the efficiency of the whole production line. In this paper, a model for computing the process of the system was established, and matrix analysis method was adopted. The result showed that good agreement can be achieved between the simulation model and the actual production line, and the system is anti-jamming. This model possibly provides a basis for the automatic process control of waste PCBs production line. With this model, many engineering problems can be reduced, such as metals and nonmetals insufficient dissociation, particles over-pulverizing, incomplete comminuting, material plugging and equipment fever.

  20. Enhanced alcohol production through on-line extraction

    SciTech Connect

    Wang, H.Y.; Robinson, F.M.; Lee, S.S.

    1981-01-01

    The main objective of this research is to overcome the inhibitory effects of desired end products produced by microorganisms during fermentation. It is demonstrated that online removal of toxic end product(s) by selected extractants such as higher alcohols and activated carbon can be achieved in the ethanol fermentation. Rapid fermentation using a high concentration of yeast cells has been proven to be capable of producing 135 g ethanol/L in eight hours. Theoretically, repeated rapid fermentation could be achieved if the viability of these yeast cells could be maintained at a high level through online ethanol extraction.

  1. Sensors and Automated Analyzers for Radionuclides

    SciTech Connect

    Grate, Jay W.; Egorov, Oleg B.

    2003-03-27

    The production of nuclear weapons materials has generated large quantities of nuclear waste and significant environmental contamination. We have developed new, rapid, automated methods for determination of radionuclides using sequential injection methodologies to automate extraction chromatographic separations, with on-line flow-through scintillation counting for real time detection. This work has progressed in two main areas: radionuclide sensors for water monitoring and automated radiochemical analyzers for monitoring nuclear waste processing operations. Radionuclide sensors have been developed that collect and concentrate radionuclides in preconcentrating minicolumns with dual functionality: chemical selectivity for radionuclide capture and scintillation for signal output. These sensors can detect pertechnetate to below regulatory levels and have been engineered into a prototype for field testing. A fully automated process monitor has been developed for total technetium in nuclear waste streams. This instrument performs sample acidification, speciation adjustment, separation and detection in fifteen minutes or less.

  2. Automation in biological crystallization.

    PubMed

    Stewart, Patrick Shaw; Mueller-Dieckmann, Jochen

    2014-06-01

    Crystallization remains the bottleneck in the crystallographic process leading from a gene to a three-dimensional model of the encoded protein or RNA. Automation of the individual steps of a crystallization experiment, from the preparation of crystallization cocktails for initial or optimization screens to the imaging of the experiments, has been the response to address this issue. Today, large high-throughput crystallization facilities, many of them open to the general user community, are capable of setting up thousands of crystallization trials per day. It is thus possible to test multiple constructs of each target for their ability to form crystals on a production-line basis. This has improved success rates and made crystallization much more convenient. High-throughput crystallization, however, cannot relieve users of the task of producing samples of high quality. Moreover, the time gained from eliminating manual preparations must now be invested in the careful evaluation of the increased number of experiments. The latter requires a sophisticated data and laboratory information-management system. A review of the current state of automation at the individual steps of crystallization with specific attention to the automation of optimization is given.

  3. Automation in biological crystallization

    PubMed Central

    Shaw Stewart, Patrick; Mueller-Dieckmann, Jochen

    2014-01-01

    Crystallization remains the bottleneck in the crystallographic process leading from a gene to a three-dimensional model of the encoded protein or RNA. Automation of the individual steps of a crystallization experiment, from the preparation of crystallization cocktails for initial or optimization screens to the imaging of the experiments, has been the response to address this issue. Today, large high-throughput crystallization facilities, many of them open to the general user community, are capable of setting up thousands of crystallization trials per day. It is thus possible to test multiple constructs of each target for their ability to form crystals on a production-line basis. This has improved success rates and made crystallization much more convenient. High-throughput crystallization, however, cannot relieve users of the task of producing samples of high quality. Moreover, the time gained from eliminating manual preparations must now be invested in the careful evaluation of the increased number of experiments. The latter requires a sophisticated data and laboratory information-management system. A review of the current state of automation at the individual steps of crystallization with specific attention to the automation of optimization is given. PMID:24915074

  4. An automated flow system incorporating in-line acid dissolution of bismuth metal from a cyclotron irradiated target assembly for use in the isolation of astatine-211.

    PubMed

    O'Hara, Matthew J; Krzysko, Anthony J; Niver, Cynthia M; Morrison, Samuel S; Owsley, Stanley L; Hamlin, Donald K; Dorman, Eric F; Scott Wilbur, D

    2017-04-01

    Astatine-211 ((211)At) is a promising cyclotron-produced radionuclide being investigated for use in targeted alpha therapy. The wet chemical isolation of trace quantities of (211)At, produced within several grams of Bi metal deposited onto an aluminum cyclotron target assembly, involves a multi-step procedure. Because the (211)At isolation method is labor-intensive and complex, automation of the method is being developed to facilitate routine processing at the University of Washington and to make it easier to transfer the process to other institutions. As part of that automation effort, a module useful in the initial step of the isolation procedure, dissolution of the Bi target, was designed and tested. The computer-controlled module performs in-line dissolution of Bi metal from the target assembly using an enclosed target dissolution block, routing the resulting solubilized (211)At/Bi mixture to the subsequent process step. The primary parameters involved in Bi metal solubilization (influent HNO3 concentration and flow rate) were optimized prior to evaluation of the system using replicate (211)At-bearing cyclotron irradiated targets. The results indicate that the system performs in a predictable and reproducible manner, with cumulative Bi and (211)At recoveries following a sigmoidal function.

  5. ELIXYS - a fully automated, three-reactor high-pressure radiosynthesizer for development and routine production of diverse PET tracers

    PubMed Central

    2013-01-01

    Background Automated radiosynthesizers are vital for routine production of positron-emission tomography tracers to minimize radiation exposure to operators and to ensure reproducible synthesis yields. The recent trend in the synthesizer industry towards the use of disposable kits aims to simplify setup and operation for the user, but often introduces several limitations related to temperature and chemical compatibility, thus requiring reoptimization of protocols developed on non-cassette-based systems. Radiochemists would benefit from a single hybrid system that provides tremendous flexibility for development and optimization of reaction conditions while also providing a pathway to simple, cassette-based production of diverse tracers. Methods We have designed, built, and tested an automated three-reactor radiosynthesizer (ELIXYS) to provide a flexible radiosynthesis platform suitable for both tracer development and routine production. The synthesizer is capable of performing high-pressure and high-temperature reactions by eliminating permanent tubing and valve connections to the reaction vessel. Each of the three movable reactors can seal against different locations on disposable cassettes to carry out different functions such as sealed reactions, evaporations, and reagent addition. A reagent and gas handling robot moves sealed reagent vials from storage locations in the cassette to addition positions and also dynamically provides vacuum and inert gas to ports on the cassette. The software integrates these automated features into chemistry unit operations (e.g., React, Evaporate, Add) to intuitively create synthesis protocols. 2-Deoxy-2-[18F]fluoro-5-methyl-β-l-arabinofuranosyluracil (l-[18F]FMAU) and 2-deoxy-2-[18F]fluoro-β-d-arabinofuranosylcytosine (d-[18F]FAC) were synthesized to validate the system. Results l-[18F]FMAU and d-[18F]FAC were successfully synthesized in 165 and 170 min, respectively, with decay-corrected radiochemical yields of 46% ± 1% (n = 6

  6. Implementation of product-line management in a hospital pharmacy department.

    PubMed

    Del Vecchio-Feinberg, G J; Sheinman, C H

    1990-09-01

    The development and implementation of product-line management (PLM) in a pharmacy department is reviewed. The PLM system of hospital organization shifts the emphasis from function to product. The pharmacy department at a 737-bed nonprofit hospital adopted PLM in an effort to reach more directly the physician and patient markets, enhance the image of pharmacy, and help meet requirements of the Joint Commission on Accreditation of Healthcare Organizations. The department surveyed physicians and administrators to identify their product and service needs and surveyed pharmacy staff members to identify the perceived benefits and risks of a PLM system. A strategic-planning session was held to decide how best to match the pharmacy department's product lines with market needs. The team leaders were renamed clinical supervisors and were no longer responsible for defined physical areas but rather for clinical matters relating to patients in the product line assigned. Pharmacy's chosen product lines were oncology services, neuropsychiatry, maternal and child care, cardiovascular, operating room-anesthesia-pain clinic, and general medical. The transition is being accomplished one product line at a time; interested team leaders transfer into clinical supervisor positions by achieving clinical expertise within the relevant product lines. Despite some initial confusion, PLM contributed to job satisfaction and morale and allowed the pharmacy department to provide increased clinical consultation and intervention services. PLM enhanced the clinical pharmacy program and focused clinical services on the physician and ultimately the patient.

  7. Radiolytic hydrogen production from process vessels in HB line - production rates compared to evolution rates and discussion of LASL reviews

    SciTech Connect

    Bibler, N.E.

    1992-11-12

    Hydrogen production from radiolysis of aqueous solutions can create a safety hazard since hydrogen is flammable. At times this production can be significant, especially in HB line where nitric acid solutions containing high concentrations of Pu-238, an intense alpha emitter, are processed. The hydrogen production rates from these solutions are necessary for safety analyses of these process systems. The methods and conclusions of hydrogen production rate tests are provided in this report.

  8. On-line: Changing Products, Technologies and Roles.

    ERIC Educational Resources Information Center

    Gallina, Paul

    1986-01-01

    This article outlines the technological developments that have taken place in the online information field and their effects on the role of librarians as information intermediaries. Discussion covers changing technologies; products (data bank switch, electronic publishing and full-text databases, user friendly access and end user searching); and…

  9. A Case Study in Successful Product Line Development.

    DTIC Science & Technology

    1996-10-01

    risk decreases). Deployed products also serve as high-quality engineering prototypes, providing highly detailed performance models. Although not standard ...members, and identifying the ways in which members can vary from one another * software architecture: adopting a standard skeletal infrastructure that...shift today would, we believe, be in a much less tenuous position. Microcomputers, networks, portable operating systems, open systems standards , object

  10. Development of an automated on-line pre-column derivatization procedure for sensitive determination of histamine in food with high-performance liquid chromatography-fluorescence detection.

    PubMed

    Peng, Jin-Feng; Fang, Ke-Teng; Xie, Dong-Hua; Ding, Bin; Yin, Ju-Yi; Cui, Xiao-Mei; Zhang, Ying; Liu, Jing-Fu

    2008-10-31

    An improved sensitive method was developed and validated for the determination of histamine in food samples by using automated on-line pre-column derivatization coupled with high performance liquid chromatography and fluorescence detection (HPLC-FLD). o-Phthaldialdehyde (OPA) was adopted as derivatization reagent, and a "sandwich" (OPA+histamine+OPA) aspiration mode for the automated on-line pre-column derivatization was found to efficiently enhance the method sensitivity and precision. Histamine in food samples was efficiently extracted with a methanol-phosphate buffer solution (50:50, v/v) at 60 degrees C for 30 min, and purified with Waters Oasis MCX solid-phase extraction (SPE) cartridge. The limit of quantification for this method is 0.2 mg/kg, which is very sensitive for histamine determination. With the "sandwich" injection program, 3.7% of relative standard deviation (RSD) was achieved by five replicative determinations of a sample blank spiked with 0.25 mg/kg histamine standard. Histamine in food samples such as fumitory skipjack and mackerel was analyzed with relative recoveries over 95% at spiking level of 150 mg/kg, as well as canned tuna fish and cheese with relative recoveries up to 98% at spiking levels of 0.50 and 5.0 mg/kg, respectively. The proposed method was validated with a sample from the Food Analysis Performance Assessment Scheme (FAPAS) as a standard certified material; and the results (140+/-6 mg/kg) agreed well with the assigned value (139 mg/kg).

  11. Automated and sensitive analysis of 28-epihomobrassinolide in Arabidopsis thaliana by on-line polymer monolith microextraction coupled to liquid chromatography-mass spectrometry.

    PubMed

    Wang, Xin; Ma, Qiao; Li, Min; Chang, Cuilan; Bai, Yu; Feng, Yuqi; Liu, Huwei

    2013-11-22

    By on-line solid phase microextraction with polymer monolith coupled to liquid chromatography-mass spectrometry (SPME-LC-MS), an automated and sensitive method for analysis of the endogenous 28-epihomobrassinolide (28-epihomoBR) in Arabidopsis thaliana was developed in this work. Firstly, a poly(methacrylic acid-co-ethylene dimethacrylate) (poly(MAA-co-EDMA)) monolith was prepared in the capillary and applied in in-tube SPME. Polyethylene glycol (PEG) was used as porogen to adjust the specific surface area and hydrophobicity of the target monolith to get satisfactory permeability, high mechanical strength and good stability. The optimized monolith was then served as extraction medium for analysis of the derivatized 28-epihomoBR in plant samples with the cleanup of matrix and enrichment of desired analyte at the same time. Good linearity was obtained in the linear range of 5-500 ng/L with the coefficient of determination (R(2)) of 0.9996. The limit of detection (S/N=3) of 28-epihomoBR was found to be 2.0 ng/L and the limit of quantification (S/N=10) was 5.0 ng/L. Using this method, the endogenous 0.101 ng/g (FW) 28-epihomoBR was successfully detected from only 400mg A. thaliana samples with satisfactory recovery (80.3-92.1%) and reproducibility (RSD 6.8-9.6%). Comparing with other sample pretreatment methods, this automated on-line SPME-LC-MS method is rapid, sensitive, reproducible and laborsaving.

  12. Information logistics: A production-line approach to information services

    NASA Technical Reports Server (NTRS)

    Adams, Dennis; Lee, Chee-Seng

    1991-01-01

    Logistics can be defined as the process of strategically managing the acquisition, movement, and storage of materials, parts, and finished inventory (and the related information flow) through the organization and its marketing channels in a cost effective manner. It is concerned with delivering the right product to the right customer in the right place at the right time. The logistics function is composed of inventory management, facilities management, communications unitization, transportation, materials management, and production scheduling. The relationship between logistics and information systems is clear. Systems such as Electronic Data Interchange (EDI), Point of Sale (POS) systems, and Just in Time (JIT) inventory management systems are important elements in the management of product development and delivery. With improved access to market demand figures, logisticians can decrease inventory sizes and better service customer demand. However, without accurate, timely information, little, if any, of this would be feasible in today's global markets. Information systems specialists can learn from logisticians. In a manner similar to logistics management, information logistics is concerned with the delivery of the right data, to the ring customer, at the right time. As such, information systems are integral components of the information logistics system charged with providing customers with accurate, timely, cost-effective, and useful information. Information logistics is a management style and is composed of elements similar to those associated with the traditional logistics activity: inventory management (data resource management), facilities management (distributed, centralized and decentralized information systems), communications (participative design and joint application development methodologies), unitization (input/output system design, i.e., packaging or formatting of the information), transportations (voice, data, image, and video communication systems

  13. Elements of EAF automation processes

    NASA Astrophysics Data System (ADS)

    Ioana, A.; Constantin, N.; Dragna, E. C.

    2017-01-01

    Our article presents elements of Electric Arc Furnace (EAF) automation. So, we present and analyze detailed two automation schemes: the scheme of electrical EAF automation system; the scheme of thermic EAF automation system. The application results of these scheme of automation consists in: the sensitive reduction of specific consummation of electrical energy of Electric Arc Furnace, increasing the productivity of Electric Arc Furnace, increase the quality of the developed steel, increasing the durability of the building elements of Electric Arc Furnace.

  14. Architecture-Based Unit Testing of the Flight Software Product Line

    NASA Technical Reports Server (NTRS)

    Ganesan, Dharmalingam; Lindvall, Mikael; McComas, David; Bartholomew, Maureen; Slegel, Steve; Medina, Barbara

    2010-01-01

    This paper presents an analysis of the unit testing approach developed and used by the Core Flight Software (CFS) product line team at the NASA GSFC. The goal of the analysis is to understand, review, and reconunend strategies for improving the existing unit testing infrastructure as well as to capture lessons learned and best practices that can be used by other product line teams for their unit testing. The CFS unit testing framework is designed and implemented as a set of variation points, and thus testing support is built into the product line architecture. The analysis found that the CFS unit testing approach has many practical and good solutions that are worth considering when deciding how to design the testing architecture for a product line, which are documented in this paper along with some suggested innprovennents.

  15. Opitmizing a Beef Production System Using Specialized Sire and Dam Lines

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Crossbreeding is an effective method for improving efficiency of production in commercial cow-calf operations. It exploits available heterosis (hybrid vigor) and complementarity between different breeds or populations (lines). Before adopting a crossbreeding system, commercial cattle producers shou...

  16. Increasing Student Interest and Comprehension of Production Planning and Control and Operations Performance Measurement Concepts Using a Production Line Game

    ERIC Educational Resources Information Center

    Cox, James F., III; Walker, Edward D., II

    2005-01-01

    Production planning and control (PPC) systems and operations performance measures are topics that students generally find both boring and difficult to understand. In the article, the authors present a production line game that they have found to be an effective tool to increase student interest in the topics as well as student comprehension. The…

  17. Verhulst and stochastic models for comparing mechanisms of MAb productivity in six CHO cell lines.

    PubMed

    Shirsat, Nishikant; Avesh, Mohd; English, Niall J; Glennon, Brian; Al-Rubeai, Mohamed

    2016-08-01

    The present study validates previously published methodologies-stochastic and Verhulst-for modelling the growth and MAb productivity of six CHO cell lines grown in batch cultures. Cytometric and biochemical data were used to model growth and productivity. The stochastic explanatory models were developed to improve our understanding of the underlying mechanisms of growth and productivity, whereas the Verhulst mechanistic models were developed for their predictability. The parameters of the two sets of models were compared for their biological significance. The stochastic models, based on the cytometric data, indicated that the productivity mechanism is cell specific. However, as shown before, the modelling results indicated that G2 + ER indicate high productivity, while G1 + ER indicate low productivity, where G1 and G2 are the cell cycle phases and ER is Endoplasmic Reticulum. In all cell lines, growth proved to be inversely proportional to the cumulative G1 time (CG1T) for the G1 phase, whereas productivity was directly proportional to ER. Verhulst's rule, "the lower the intrinsic growth factor (r), the higher the growth (K)," did not hold for growth across all cell lines but held good for the cell lines with the same growth mechanism-i.e., r is cell specific. However, the Verhulst productivity rule, that productivity is inversely proportional to the intrinsic productivity factor (r x ), held well across all cell lines in spite of differences in their mechanisms for productivity-that is, r x is not cell specific. The productivity profile, as described by Verhulst's logistic model, is very similar to the Michaelis-Menten enzyme kinetic equation, suggesting that productivity is more likely enzymatic in nature. Comparison of the stochastic and Verhulst models indicated that CG1T in the cytometric data has the same significance as r, the intrinsic growth factor in the Verhulst models. The stochastic explanatory and the Verhulst logistic models can explain the

  18. Product-line selection and pricing with remanufacturing under availability constraints

    NASA Astrophysics Data System (ADS)

    Aras, Necati; Esenduran, G.÷k.‡e.; Altinel, I. Kuban

    2004-12-01

    Product line selection and pricing are two crucial decisions for the profitability of a manufacturing firm. Remanufacturing, on the other hand, may be a profitable strategy that captures the remaining value in used products. In this paper we develop a mixed-integer nonlinear programming model form the perspective of an original equipment manufacturer (OEM). The objective of the OEM is to select products to manufacture and remanufacture among a set of given alternatives and simultaneously determine their prices so as to maximize its profit. It is assumed that the probability a customer selects a product is proportional to its utility and inversely proportional to its price. The utility of a product is an increasing function of its perceived quality. In our base model, products are discriminated by their unit production costs and utilities. We also analyze a case where remanufacturing is limited by the available quantity of collected remanufacturable products. We show that the resulting problem is decomposed into the pricing and product line selection subproblems. Pricing problem is solved by a variant of the simplex search procedure which can also handle constraints, while complete enumeration and a genetic algorithm are used for the solution of the product line selection problem. A number of experiments are carried out to identify conditions under which it is economically viable for the firm to sell remanufactured products. We also determine the optimal utility and unit production cost values of a remanufactured product, which maximizes the total profit of the OEM.

  19. Automated on-line preconcentration of trace aqueous mercury with gold trap focusing for cold vapor atomic absorption spectrometry.

    PubMed

    Puanngam, Mahitti; Dasgupta, Purnendu K; Unob, Fuangfa

    2012-09-15

    A fully automated system for the determination of trace mercury in water by cold vapor atomic absorption spectrometry (CVAAS) is reported. The system uses preconcentration on a novel sorbent followed by liberation of the mercury and focusing by a gold trap. Mercury ions were extracted from water samples by passage through a solid phase sorbent column containing 2-(3-(2-aminoethylthio)propylthio)ethanamine modified silica gel. The captured mercury is released by thiourea and then elemental Hg is liberated by sodium borohydride. The vapor phase Hg is recaptured on a gold-plated tungsten filament. This is liberated as a sharp pulse (half-width<2 s) by directly electrically heating the tungsten filament in a dry argon stream. The mercury is measured by CVAAS; no moisture removal is needed. The effects of chloride and selected interfering ions were studied. The sample loading flow rate and argon flow rates for solution purging and filament sweeping were optimized. An overall 50-fold improvement in the limit of detection was observed relative to direct measurement by CVAAS. With a relatively modest multi-user instrument we attained a limit of detection of 35 ng L(-1) with 12% RSD at 0.20 μg L(-1) Hg level. The method was successfully applied to accurately determine sub-μg L(-1) level Hg in standard reference water samples.

  20. Designing of robotic production lines using CAx software

    NASA Astrophysics Data System (ADS)

    Wróbel, A.; Langer, P.

    2015-11-01

    Present market conditions causes that modern control systems of robotized manufacturing cells should be characterized by the much greater degree of flexibility, selforganization and, above all, adaptability to emerging outer excitations. The phenomenon of information distribution is one of the most important features of modern control systems. In the paper is presented the approach, based on application of multi-agent systems, for supporting the operation of robotized manufacturing cells. The aim of this approach is to obtain the flexible response to outer excitations and preventing situations that might cause the delay of the production process. The presented paper includes description of the concept of an informatics system designed for controlling the work of production systems, including work cells. Such systems could operate independently if it would be equipped with the selforganization mechanism. It is possible in the case of the proposed multi-agent system. The implementation of the presented concept will follow the present analysis of the described concept. The advantage of the proposed concept is its hierarchical depiction that allows integrating different utilized informatics tools in one complex system. It allows preparing the final computer program.

  1. Lines

    ERIC Educational Resources Information Center

    Mires, Peter B.

    2006-01-01

    National Geography Standards for the middle school years generally stress the teaching of latitude and longitude. There are many creative ways to explain the great grid that encircles our planet, but the author has found that students in his college-level geography courses especially enjoy human-interest stories associated with lines of latitude…

  2. Contact line pinning favors the mass production of monodisperse microbubbles.

    NASA Astrophysics Data System (ADS)

    Gordillo, Jose Manuel; Campo-Cortes, Francisco; Riboux, Guillaume

    2015-11-01

    A robust method for the generation of phospholipid covered monodisperse microbubbles of diameters ~10 microns at production rates exceeding 0.1 MHz, is presented here. We show that bubbles are periodically formed from the tip of a long and thin gas ligament stabilized thanks to both the strong favorable pressure gradient existing at the entrance region of a long rectangular PDMS-PDMS channel and to the pinning of the gas-liquid interface at a centered groove of several microns width placed on one of its walls. Moreover, the long exit channel incorporated in our design, favors the transport of phospholipid molecules towards the gas-liquid interface. Our experiments show that the resulting phospholipid shell inhibit both the diffusion of the gas in the surrounding liquid as well as the coalescence between contacting bubbles. These evidences indicate that the proposed method is suitable for the generation of monodisperse microbubbles for diagnosis or therapeutical applications.

  3. Automated DNA Sequencing System

    SciTech Connect

    Armstrong, G.A.; Ekkebus, C.P.; Hauser, L.J.; Kress, R.L.; Mural, R.J.

    1999-04-25

    Oak Ridge National Laboratory (ORNL) is developing a core DNA sequencing facility to support biological research endeavors at ORNL and to conduct basic sequencing automation research. This facility is novel because its development is based on existing standard biology laboratory equipment; thus, the development process is of interest to the many small laboratories trying to use automation to control costs and increase throughput. Before automation, biology Laboratory personnel purified DNA, completed cycle sequencing, and prepared 96-well sample plates with commercially available hardware designed specifically for each step in the process. Following purification and thermal cycling, an automated sequencing machine was used for the sequencing. A technician handled all movement of the 96-well sample plates between machines. To automate the process, ORNL is adding a CRS Robotics A- 465 arm, ABI 377 sequencing machine, automated centrifuge, automated refrigerator, and possibly an automated SpeedVac. The entire system will be integrated with one central controller that will direct each machine and the robot. The goal of this system is to completely automate the sequencing procedure from bacterial cell samples through ready-to-be-sequenced DNA and ultimately to completed sequence. The system will be flexible and will accommodate different chemistries than existing automated sequencing lines. The system will be expanded in the future to include colony picking and/or actual sequencing. This discrete event, DNA sequencing system will demonstrate that smaller sequencing labs can achieve cost-effective the laboratory grow.

  4. Automated and Multiplexed Soft Lithography for the Production of Low-Density DNA Microarrays

    PubMed Central

    Fredonnet, Julie; Foncy, Julie; Cau, Jean-Christophe; Séverac, Childérick; François, Jean Marie; Trévisiol, Emmanuelle

    2016-01-01

    Microarrays are established research tools for genotyping, expression profiling, or molecular diagnostics in which DNA molecules are precisely addressed to the surface of a solid support. This study assesses the fabrication of low-density oligonucleotide arrays using an automated microcontact printing device, the InnoStamp 40®. This automate allows a multiplexed deposition of oligoprobes on a functionalized surface by the use of a MacroStampTM bearing 64 individual pillars each mounted with 50 circular micropatterns (spots) of 160 µm diameter at 320 µm pitch. Reliability and reuse of the MacroStampTM were shown to be fast and robust by a simple washing step in 96% ethanol. The low-density microarrays printed on either epoxysilane or dendrimer-functionalized slides (DendriSlides) showed excellent hybridization response with complementary sequences at unusual low probe and target concentrations, since the actual probe density immobilized by this technology was at least 10-fold lower than with the conventional mechanical spotting. In addition, we found a comparable hybridization response in terms of fluorescence intensity between spotted and printed oligoarrays with a 1 nM complementary target by using a 50-fold lower probe concentration to produce the oligoarrays by the microcontact printing method. Taken together, our results lend support to the potential development of this multiplexed microcontact printing technology employing soft lithography as an alternative, cost-competitive tool for fabrication of low-density DNA microarrays. PMID:27681742

  5. The modular design of robotic workcells in a flexible production line

    NASA Astrophysics Data System (ADS)

    Banas, W.; Sekala, A.; Gwiazda, A.; Foit, K.; Hryniewicz, P.; Kost, G.

    2015-11-01

    In the case of large-scale and mass production lines often the same model of an industrial robot is used in various places of the line and is intended to various task. However, the replacement of one industrial robot to another is a long lasting and arduous process. It requires stopping all the production line and sometimes even dismantling the whole workcell. Such situations are not frequent in production lines that are not flexible. They are related the most often with the failure on an industrial robot. However, during the designing of a flexible production line the ability to replace any robot, which is unrestricted, fast and trouble-free, greatly increase the flexibility level of such line. It could be realized by modular design of the proposed production line. In this way it could be possible to change any elements of such production system. But this approach needs to apply the specialized informatics system. This paper presents the obtained design of several versions of the same production workcell. Each, succeeding version of the designed production workcell contains more and more modular elements. Thereby it would be presented the evolution of a workcell design beginning from the typical design and ending with the fully modular one. One of tools needed to realize this task is the elaboration of a base of modules and typical joint and mounting elements that could be utilised in the described designing process. It is also presented the guidance information about the designing and programming processes useful at each stage of analysed process.

  6. 40 CFR 1054.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... fails the production-line testing requirements? 1054.315 Section 1054.315 Protection of Environment... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass-fail criteria...

  7. 40 CFR 1048.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... fails the production-line testing requirements? 1048.315 Section 1048.315 Protection of Environment... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass/fail criteria for...

  8. 40 CFR 1048.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.320 What happens if one of my production-line engines fails to meet emission standards? If you have a production-line engine with final... 40 Protection of Environment 32 2010-07-01 2010-07-01 false What happens if one of my...

  9. 40 CFR 1042.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the production-line testing requirements? 1042.325 Section 1042.325 Protection of Environment... MARINE COMPRESSION-IGNITION ENGINES AND VESSELS Testing Production-line Engines § 1042.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend...

  10. 40 CFR 1048.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.320 What happens if one of my production-line engines fails to meet emission standards? If you have a production-line engine with final... 40 Protection of Environment 33 2011-07-01 2011-07-01 false What happens if one of my...

  11. 40 CFR 1051.310 - How must I select vehicles or engines for production-line testing?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... for production-line testing? 1051.310 Section 1051.310 Protection of Environment ENVIRONMENTAL... VEHICLES Testing Production-Line Vehicles and Engines § 1051.310 How must I select vehicles or engines for production-line testing? (a) Test engines from each engine family as described in this section based on...

  12. 40 CFR 1054.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the production-line testing requirements? 1054.325 Section 1054.325 Protection of Environment... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of conformity for...

  13. 40 CFR 1048.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.320 What happens if one of my production-line engines fails to meet emission standards? If you have a production-line engine with final... 40 Protection of Environment 34 2012-07-01 2012-07-01 false What happens if one of my...

  14. 40 CFR 1045.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the production-line testing requirements? 1045.325 Section 1045.325 Protection of Environment... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of...

  15. 40 CFR 1054.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.320 What happens if one of my production-line engines fails to meet emission standards? (a) If you have a production-line engine with final... 40 Protection of Environment 33 2011-07-01 2011-07-01 false What happens if one of my...

  16. 40 CFR 1048.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the production-line testing requirements? 1048.325 Section 1048.325 Protection of Environment... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of conformity for...

  17. 40 CFR 1048.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... fails the production-line testing requirements? 1048.315 Section 1048.315 Protection of Environment... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass/fail criteria for...

  18. 40 CFR 1051.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the production-line testing requirements? 1051.325 Section 1051.325 Protection of Environment... ENGINES AND VEHICLES Testing Production-Line Vehicles and Engines § 1051.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of...

  19. 40 CFR 1054.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... fails the production-line testing requirements? 1054.315 Section 1054.315 Protection of Environment... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass-fail criteria...

  20. 40 CFR 1051.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... fails the production-line testing requirements? 1051.315 Section 1051.315 Protection of Environment... ENGINES AND VEHICLES Testing Production-Line Vehicles and Engines § 1051.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass-fail criteria...

  1. 40 CFR 1051.310 - How must I select vehicles or engines for production-line testing?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... for production-line testing? 1051.310 Section 1051.310 Protection of Environment ENVIRONMENTAL... VEHICLES Testing Production-Line Vehicles and Engines § 1051.310 How must I select vehicles or engines for production-line testing? (a) Test engines from each engine family as described in this section based on...

  2. 40 CFR 1054.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.320 What happens if one of my production-line engines fails to meet emission standards? (a) If you have a production-line engine with final... 40 Protection of Environment 34 2013-07-01 2013-07-01 false What happens if one of my...

  3. 40 CFR 1045.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the production-line testing requirements? 1045.325 Section 1045.325 Protection of Environment... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of...

  4. 40 CFR 1054.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the production-line testing requirements? 1054.325 Section 1054.325 Protection of Environment... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of conformity for...

  5. 40 CFR 1051.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the production-line testing requirements? 1051.325 Section 1051.325 Protection of Environment... ENGINES AND VEHICLES Testing Production-Line Vehicles and Engines § 1051.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of...

  6. 40 CFR 1042.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the production-line testing requirements? 1042.325 Section 1042.325 Protection of Environment... MARINE COMPRESSION-IGNITION ENGINES AND VESSELS Testing Production-line Engines § 1042.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend...

  7. 40 CFR 1051.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... fails the production-line testing requirements? 1051.315 Section 1051.315 Protection of Environment... ENGINES AND VEHICLES Testing Production-Line Vehicles and Engines § 1051.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass-fail criteria...

  8. 40 CFR 1054.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.320 What happens if one of my production-line engines fails to meet emission standards? (a) If you have a production-line engine with final... 40 Protection of Environment 33 2014-07-01 2014-07-01 false What happens if one of my...

  9. 40 CFR 1042.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the production-line testing requirements? 1042.325 Section 1042.325 Protection of Environment... MARINE COMPRESSION-IGNITION ENGINES AND VESSELS Testing Production-line Engines § 1042.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend...

  10. 40 CFR 1048.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the production-line testing requirements? 1048.325 Section 1048.325 Protection of Environment... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of conformity for...

  11. 40 CFR 1042.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the production-line testing requirements? 1042.325 Section 1042.325 Protection of Environment... MARINE COMPRESSION-IGNITION ENGINES AND VESSELS Testing Production-line Engines § 1042.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend...

  12. 40 CFR 1051.310 - How must I select vehicles or engines for production-line testing?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... for production-line testing? 1051.310 Section 1051.310 Protection of Environment ENVIRONMENTAL... VEHICLES Testing Production-Line Vehicles and Engines § 1051.310 How must I select vehicles or engines for production-line testing? (a) Test engines from each engine family as described in this section based on...

  13. 40 CFR 1045.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.320 What happens if one of my production-line engines fails to meet emission standards? (a) If you have a production-line engine with final... 40 Protection of Environment 33 2011-07-01 2011-07-01 false What happens if one of my...

  14. 40 CFR 1045.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the production-line testing requirements? 1045.325 Section 1045.325 Protection of Environment... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of...

  15. 40 CFR 1054.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the production-line testing requirements? 1054.325 Section 1054.325 Protection of Environment... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of conformity for...

  16. 40 CFR 1045.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the production-line testing requirements? 1045.325 Section 1045.325 Protection of Environment... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of...

  17. 40 CFR 1045.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the production-line testing requirements? 1045.325 Section 1045.325 Protection of Environment... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of...

  18. 40 CFR 1045.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.320 What happens if one of my production-line engines fails to meet emission standards? (a) If you have a production-line engine with final... 40 Protection of Environment 33 2014-07-01 2014-07-01 false What happens if one of my...

  19. 40 CFR 1054.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.320 What happens if one of my production-line engines fails to meet emission standards? (a) If you have a production-line engine with final... 40 Protection of Environment 32 2010-07-01 2010-07-01 false What happens if one of my...

  20. 40 CFR 1054.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the production-line testing requirements? 1054.325 Section 1054.325 Protection of Environment... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of conformity for...

  1. 40 CFR 1054.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... fails the production-line testing requirements? 1054.315 Section 1054.315 Protection of Environment... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass-fail criteria...

  2. 40 CFR 1045.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... fails the production-line testing requirements? 1045.315 Section 1045.315 Protection of Environment... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass-fail criteria...

  3. 40 CFR 1048.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.320 What happens if one of my production-line engines fails to meet emission standards? If you have a production-line engine with final... 40 Protection of Environment 33 2014-07-01 2014-07-01 false What happens if one of my...

  4. 40 CFR 1051.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the production-line testing requirements? 1051.325 Section 1051.325 Protection of Environment... ENGINES AND VEHICLES Testing Production-Line Vehicles and Engines § 1051.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of...

  5. 40 CFR 1048.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the production-line testing requirements? 1048.325 Section 1048.325 Protection of Environment... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of conformity for...

  6. 40 CFR 1048.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.320 What happens if one of my production-line engines fails to meet emission standards? If you have a production-line engine with final... 40 Protection of Environment 34 2013-07-01 2013-07-01 false What happens if one of my...

  7. 40 CFR 1042.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the production-line testing requirements? 1042.325 Section 1042.325 Protection of Environment... MARINE COMPRESSION-IGNITION ENGINES AND VESSELS Testing Production-line Engines § 1042.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend...

  8. 40 CFR 1051.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the production-line testing requirements? 1051.325 Section 1051.325 Protection of Environment... ENGINES AND VEHICLES Testing Production-Line Vehicles and Engines § 1051.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of...

  9. 40 CFR 1054.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.320 What happens if one of my production-line engines fails to meet emission standards? (a) If you have a production-line engine with final... 40 Protection of Environment 34 2012-07-01 2012-07-01 false What happens if one of my...

  10. 40 CFR 1045.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.320 What happens if one of my production-line engines fails to meet emission standards? (a) If you have a production-line engine with final... 40 Protection of Environment 32 2010-07-01 2010-07-01 false What happens if one of my...

  11. 40 CFR 1051.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the production-line testing requirements? 1051.325 Section 1051.325 Protection of Environment... ENGINES AND VEHICLES Testing Production-Line Vehicles and Engines § 1051.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of...

  12. 40 CFR 1045.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.320 What happens if one of my production-line engines fails to meet emission standards? (a) If you have a production-line engine with final... 40 Protection of Environment 34 2013-07-01 2013-07-01 false What happens if one of my...

  13. 40 CFR 1051.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... fails the production-line testing requirements? 1051.315 Section 1051.315 Protection of Environment... ENGINES AND VEHICLES Testing Production-Line Vehicles and Engines § 1051.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass-fail criteria...

  14. 40 CFR 1045.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... fails the production-line testing requirements? 1045.315 Section 1045.315 Protection of Environment... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass-fail criteria...

  15. 40 CFR 1048.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... fails the production-line testing requirements? 1048.315 Section 1048.315 Protection of Environment... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass/fail criteria for...

  16. 40 CFR 1045.320 - What happens if one of my production-line engines fails to meet emission standards?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.320 What happens if one of my production-line engines fails to meet emission standards? (a) If you have a production-line engine with final... 40 Protection of Environment 34 2012-07-01 2012-07-01 false What happens if one of my...

  17. 40 CFR 1048.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... fails the production-line testing requirements? 1048.315 Section 1048.315 Protection of Environment... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass/fail criteria for...

  18. 40 CFR 1051.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... fails the production-line testing requirements? 1051.315 Section 1051.315 Protection of Environment... ENGINES AND VEHICLES Testing Production-Line Vehicles and Engines § 1051.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass-fail criteria...

  19. 40 CFR 1048.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the production-line testing requirements? 1048.325 Section 1048.325 Protection of Environment... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of conformity for...

  20. 40 CFR 1045.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... fails the production-line testing requirements? 1045.315 Section 1045.315 Protection of Environment... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass-fail criteria...

  1. 40 CFR 1048.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the production-line testing requirements? 1048.325 Section 1048.325 Protection of Environment... SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of conformity for...

  2. 40 CFR 1054.325 - What happens if an engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the production-line testing requirements? 1054.325 Section 1054.325 Protection of Environment... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.325 What happens if an engine family fails the production-line testing requirements? (a) We may suspend your certificate of conformity for...

  3. 40 CFR 1051.310 - How must I select vehicles or engines for production-line testing?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... for production-line testing? 1051.310 Section 1051.310 Protection of Environment ENVIRONMENTAL... VEHICLES Testing Production-Line Vehicles and Engines § 1051.310 How must I select vehicles or engines for production-line testing? (a) Test engines from each engine family as described in this section based on...

  4. 40 CFR 1054.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... fails the production-line testing requirements? 1054.315 Section 1054.315 Protection of Environment... SPARK-IGNITION ENGINES AND EQUIPMENT Production-line Testing § 1054.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass-fail criteria...

  5. 40 CFR 1045.315 - How do I know when my engine family fails the production-line testing requirements?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... fails the production-line testing requirements? 1045.315 Section 1045.315 Protection of Environment... PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.315 How do I know when my engine family fails the production-line testing requirements? This section describes the pass-fail criteria...

  6. HADES PC network: an automated data entry system

    SciTech Connect

    Hegemann, D.L.

    1986-09-12

    Mound's Health Physics section is faced with an increasing need to store and retrieve radiological data. This need has been addressed by the Health Physics Automated Data Entry System (HADES) which assumed a full production status on April 1, 1986. Mound's Technical Computer Support group implemented HADES in a series of phases which allowed high priority needs to be immediately supported. As a result of the system's personal computer-based structure, additional capabilities such as automated data acquisition were easily brought on-line. Since its inception in the first quarter of 1984, HADES has matured into a cost-efficient automated data acquisition system for Mound's Health Physics section.

  7. Supporting Development of Satellite's Guidance Navigation and Control Software: A Product Line Approach

    NASA Technical Reports Server (NTRS)

    McComas, David; Stark, Michael; Leake, Stephen; White, Michael; Morisio, Maurizio; Travassos, Guilherme H.; Powers, Edward I. (Technical Monitor)

    2000-01-01

    The NASA Goddard Space Flight Center Flight Software Branch (FSB) is developing a Guidance, Navigation, and Control (GNC) Flight Software (FSW) product line. The demand for increasingly more complex flight software in less time while maintaining the same level of quality has motivated us to look for better FSW development strategies. The GNC FSW product line has been planned to address the core GNC FSW functionality very similar on many recent low/near Earth missions in the last ten years. Unfortunately these missions have not accomplished significant drops in development cost since a systematic approach towards reuse has not been adopted. In addition, new demands are continually being placed upon the FSW which means the FSB must become more adept at providing GNC FSW functionality's core so it can accommodate additional requirements. These domain features together with engineering concepts are influencing the specification, description and evaluation of FSW product line. Domain engineering is the foundation for emerging product line software development approaches. A product line is 'A family of products designed to take advantage of their common aspects and predicted variabilities'. In our product line approach, domain engineering includes the engineering activities needed to produce reusable artifacts for a domain. Application engineering refers to developing an application in the domain starting from reusable artifacts. The focus of this paper is regarding the software process, lessons learned and on how the GNC FSW product line manages variability. Existing domain engineering approaches do not enforce any specific notation for domain analysis or commonality and variability analysis. Usually, natural language text is the preferred tool. The advantage is the flexibility and adapt ability of natural language. However, one has to be ready to accept also its well-known drawbacks, such as ambiguity, inconsistency, and contradictions. While most domain analysis

  8. Product-line administration: a framework for redefining medical record department services.

    PubMed

    Postal, S N

    1990-06-01

    Product-line administration is a viable approach for managing medical records services in an environment that demands high quantity and quality service levels. Product-line administration directs medical record department team members to look outside of the department and seek input from the customers it is intended to serve. The feedback received may be alarming at first, as the current state of products usually reveals a true lack of customer input. As the planning, defining, managing, and marketing phases are implemented, the road will not be easy and rewards will be slow to come. Product-line administration does not provide quick fixes, but it does provide long-term problem resolution as products are refined and new products developed to meet customer needs and expectations. In addition to better meeting the needs of the department's external customers, the department's internal customers' needs and expectations will be addressed. The participative management approach will help nurture each team member's creativity. The team members will have the opportunity to reach their full potential while reaping the rewards and benefits of providing products and services that meet the needs and expectations of all department customers. The future of the health care industry promises more changes as the country moves toward some form of prospective payment in the ambulatory setting. Reactive management and the constant struggle to catch up can no longer be accepted as a management approach. It is imperative that the medical record department be viewed as a business with product lines composed of quality products. The planning, defining, managing, and marketing components of product-line administration afford responsiveness to the current situation and the development of quality products that will ensure that medical record departments are prepared for the future.

  9. 40 CFR 1054.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) Describe any facility used to test production-line engines and state its location. (2) State the total U.S.-directed production volume and number of tests for each engine family. (3) Describe how you randomly... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, SMALL NONROAD SPARK-IGNITION ENGINES...

  10. 40 CFR 1054.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) Describe any facility used to test production-line engines and state its location. (2) State the total U.S.-directed production volume and number of tests for each engine family. (3) Describe how you randomly... (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, SMALL NONROAD SPARK-IGNITION ENGINES...

  11. GENERAL VIEW OF THE PRODUCTION LINE BEING CONVERTED FROM B26 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GENERAL VIEW OF THE PRODUCTION LINE BEING CONVERTED FROM B-26 TO B-29 PRODUCTION SHOWING THE LINK-BELT CONVEYOR SYSTEM AND ENGINE NACELLES READY FOR ASSEMBLY. WHO, 1944 - Offutt Air Force Base, Glenn L. Martin-Nebraska Bomber Plant, Building D, Peacekeeper Drive, Bellevue, Sarpy County, NE

  12. Integrating Theory and Practice: Applying the Quality Improvement Paradigm to Product Line Engineering

    NASA Technical Reports Server (NTRS)

    Stark, Michael; Hennessy, Joseph F. (Technical Monitor)

    2002-01-01

    My assertion is that not only are product lines a relevant research topic, but that the tools used by empirical software engineering researchers can address observed practical problems. Our experience at NASA has been there are often externally proposed solutions available, but that we have had difficulties applying them in our particular context. We have also focused on return on investment issues when evaluating product lines, and while these are important, one can not attain objective data on success or failure until several applications from a product family have been deployed. The use of the Quality Improvement Paradigm (QIP) can address these issues: (1) Planning an adoption path from an organization's current state to a product line approach; (2) Constructing a development process to fit the organization's adoption path; (3) Evaluation of product line development processes as the project is being developed. The QIP consists of the following six steps: (1) Characterize the project and its environment; (2) Set quantifiable goals for successful project performance; (3) Choose the appropriate process models, supporting methods, and tools for the project; (4) Execute the process, analyze interim results, and provide real-time feedback for corrective action; (5) Analyze the results of completed projects and recommend improvements; and (6) Package the lessons learned as updated and refined process models. A figure shows the QIP in detail. The iterative nature of the QIP supports an incremental development approach to product lines, and the project learning and feedback provide the necessary early evaluations.

  13. Screening of drugs in equine plasma using automated on-line solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry.

    PubMed

    Kwok, W H; Leung, David K K; Leung, Gary N W; Wan, Terence S M; Wong, Colton H F; Wong, Jenny K Y

    2010-05-07

    A rapid liquid chromatography-tandem mass spectrometry (LC-MS-MS) method was developed for the simultaneous screening of 19 drugs of different classes in equine plasma using automated on-line solid-phase extraction (SPE) coupled with a triple quadrupole mass spectrometer. Plasma samples were first protein precipitated using acetonitrile. After centrifugation, the supernatant was directly injected into the on-line SPE system and analysed by a triple quadrupole LC-MS-MS in positive electrospray ionisation (+ESI) mode with selected reaction monitoring (SRM) scan function. On-line extraction and chromatographic separation of the targeted drugs were performed using respectively a polymeric extraction column (2 cm L x 2.1mm ID, 25 microm particle size) and a reversed-phase C18 LC column (3 cm L x 2.1mm ID, 3 microm particle size) with gradient elution to provide fast analysis time. The overall instrument turnaround time was 9.5 min, inclusive of post-run and equilibration time. Plasma samples fortified with 19 targeted drugs including narcotic analgesics, local anaesthetics, antipsychotics, bronchodilators, mucolytics, corticosteroids, sedative and tranquillisers at sub-parts per billion (ppb) to low parts per trillion (ppt) levels could be consistently detected. No significant matrix interference was observed at the expected retention times of the targeted ion transitions. Over 70% of the drugs studied gave detection limits at or below 100 pg/mL, with some detection limits reaching down to 19 pg/mL. The method had been validated for extraction recovery, precision and sensitivity, and a blockage study had also been carried out. This method is used regularly in the authors' laboratory to screen for the presence of targeted drugs in pre-race plasma samples from racehorses.

  14. Automated small scale oil seed processing plant for production of fuel for diesel engines

    SciTech Connect

    Thompson, J.C.; Peterson, C.L.

    1982-01-01

    University of Idaho seed processing research is centered about a CeCoCo oil expeller. A seed preheater-auger, seed bin, meal auger, and oil pump have been constructed to complete the system, which is automated and instrumented. The press, preheater, cake removal auger, and oil transfer pump are tied into a central panel where energy use is measured and the process controlled. Extracted oil weight, meal weight, process temperature, and input energy are all recorded during operation. The oil is transferred to tanks where it settles for 48 hours or more. It is then pumped through a filtering system and stored ready to be used as an engine fuel. The plant has processed over 11,000 kg of seed with an average extraction efficiency of 78 percent. 5 tables.

  15. Transferring automation for large-scale development and production of Invader SNP assays

    NASA Astrophysics Data System (ADS)

    Neri, Bruce P.; Ganske, R.; Isaczyszyn, W.; Beaty, Edward L.

    2000-03-01

    The Human Genome Project has led to the discovery of hundreds of thousands of single nucleotide polymorphisms (SNPs). SNPs can act as genetic markers to create high- density maps of the human genome for large-scale genetic analysis for evaluating links between genetic mutations and human diseases and for performing association studies. To create those maps, assays capable of detecting many different SNPs must be developed rapidly, as additional SNPs are discovered. When both the design of and the technology used in the assays can be partially or fully automated, the development process and the time to results can be accomplished quickly and efficiently. InvaderTM technology offers a highly sensitive signal amplification system that detects and quantifies mutations and SNPs from unamplified human genomic DNA in two sequential steps.

  16. Automated on-line column-switching HPLC-MS/MS method for measuring environmental phenols and parabens in serum.

    PubMed

    Ye, Xiaoyun; Tao, Lily J; Needham, Larry L; Calafat, Antonia M

    2008-08-15

    We developed a method using on-line solid phase extraction (SPE) coupled to high performance liquid chromatography-isotope dilution tandem mass spectrometry (HPLC-MS/MS) to measure the serum concentrations of seven environmental phenols and five parabens: bisphenol A; ortho-phenylphenol; 2,4-dichlorophenol; 2,5-dichlorophenol; 2,4,5-trichlorophenol; benzophenone-3; triclosan; and methyl-, ethyl-, propyl-, butyl-, and benzyl-parabens. The phenols and parabens present in serum were retained and concentrated on a C18 reversed-phase size-exclusion SPE column, back-eluted from the SPE column while the eluate was diluted through a mixing Tee (analyte peak focusing), separated using a pair of monolithic HPLC columns, and detected by isotope dilution-MS/MS. Sample preparation did not require protein precipitation, only dilution of the serum with 0.1M formic acid. This method, which combines an on-line SPE with analyte peak focusing feature and the selective atmospheric pressure photoionization MS detection, resulted in limits of detection ranging from 0.1 to 0.5 ng/mL for most of the analytes. The high throughput and adequate sensitivity with yet a relative low serum volume used (100 microL) confirm that analytically it is possible to measure simultaneously these phenols and parabens with the precision and accuracy at sub-parts-per-billion levels required for biomonitoring. However, important additional factors, including validated sample collecting, handling, and storing protocols, as well as toxicokinetic data, are required if these measures are used for exposure assessment.

  17. a Suggestion of Simulation Framework for Verifing PLC Program & Application in Automotive Production Line

    NASA Astrophysics Data System (ADS)

    Lee, Kang-Gu; Koo, Lock-Jo; Park, Sang-Chul; Wang, Gi-Nam

    2009-08-01

    Proposed in this paper is a framework of virtual plant model for verification of PLC program by conducting the virtual plant modeling and simulation. The proposed virtual plant model consists of three types of objects: the virtual device model (object model), the intermediary transfer model (functional model) and PLC program (dynamic model). For the implementation of the proposed virtual plant model, this paper employs the I/O model which is based on Automata and Discrete Event System Specifications (DEVS) formalism. By applying an example of the automotive assembly line, nine errors in the PLC code are found and have been revised. With the proposed approach, it will be helpful to reduce the ramp up or down time of the automated manufacturing system.

  18. Work and Programmable Automation.

    ERIC Educational Resources Information Center

    DeVore, Paul W.

    A new industrial era based on electronics and the microprocessor has arrived, an era that is being called intelligent automation. Intelligent automation, in the form of robots, replaces workers, and the new products, using microelectronic devices, require significantly less labor to produce than the goods they replace. The microprocessor thus…

  19. Beam line shielding calculations for an Electron Accelerator Mo-99 production facility

    SciTech Connect

    Mocko, Michal

    2016-05-03

    The purpose of this study is to evaluate the photon and neutron fields in and around the latest beam line design for the Mo-99 production facility. The radiation dose to the beam line components (quadrupoles, dipoles, beam stops and the linear accelerator) are calculated in the present report. The beam line design assumes placement of two cameras: infra red (IR) and optical transition radiation (OTR) for continuous monitoring of the beam spot on target during irradiation. The cameras will be placed off the beam axis offset in vertical direction. We explored typical shielding arrangements for the cameras and report the resulting neutron and photon dose fields.

  20. A Control System for Tobacco Shred Production Line Based on Industrial Ethernet

    NASA Astrophysics Data System (ADS)

    Zhang, Li; Zheng, Guang; Zhang, Xinfeng; Liu, Lei; Xi, Lei

    The Industrial Ethernet based on IP realizes interconnection of industrial network and information network, and it is the most potential technology in the new industrial net products. In this paper, the defects of the original control system for tobacco shred production line are analyzed, and the new design plan of control system based on EtherNet/IP is presented. The control net adopts redundant 1000M fiber optic ring network that consists of six managed Industrial Ethernet Switches, and they are distributed to the central control room, leaf processing line, shred processing line, mixed stem shred processing line, online mositure regain processing line and cut tobacco dryer control cabinet. The switch in the central control room works in the pattern of redundancy management, which can switch the link in the event of the failure in link of ring net, the recovery time of link line is less than 500ms, and each main PLC of control section has dual Network Adapters. The plan has been applied for reform of 5000kg/h Tobacco Primary Processing Line in Nanyang Cigarette Factory of China Tobacco Henan Industrial Corporation, and the configurable software and Industry Ethernet network which has been used promots the capability of automatic control system fundamentally, showing much better transmission efficiency and reliability, realizing the goal of high cost performance and making equipment's ability of handling grow fast.

  1. JSI-124 inhibits IgE production in an IgE B cell line.

    PubMed

    Cui, Lulu; Bi, Jiacheng; Yan, Dehong; Ye, Xiufeng; Zheng, Mingxing; Yu, Guang; Wan, Xiaochun

    2017-01-29

    IgE is a key effector molecule in atopic diseases; however, the regulation mechanisms of IgE production in IgE B cells remain poorly understood. In the present study, we demonstrate that JSI-124 (cucurbitacin I), a selective STAT3 inhibitor, selectively inhibits production of IgE by a human IgE B cell line, CRL-8033 cells, while does not affect the IgG production by IgG B cell lines. In the aspect of molecular mechanism, we found that Igλ, but not Ighe, gene expression was suppressed by JSI-124. The above effects of JSI-124 were not mediated by affecting cellular proliferation or apoptosis. Furthermore, multiple B cell differentiation-related genes expression was not significantly affected by JSI-124. Taken together, we demonstrate a potential strategy of therapeutically suppressing IgE production without affecting IgG production in atopic patients.

  2. Development of a beam line for radio-isotope production at the KOMAC

    NASA Astrophysics Data System (ADS)

    Kim, Han-Sung

    2016-09-01

    A new beam line of the 100-MeV proton linac at the KOMAC (Korea Multi-purpose Accelerator Complex), aiming for RI (radioisotope) production has been constructed reflecting the increasing demands for various RIs (radioisotopes), such as Sr-82 and Cu-67 for medical applications. Proton beam with beam energy of 100 MeV and an average current of 0.6 mA is directed to the 100-mm-diameter production target through a beam window made of aluminum-beryllium alloy. Major components of the newly-installed beam line include electromagnets for bending and focusing, beam diagnostic systems such as a BPM (beam position monitor) and a BCM (beam current monitor), and a vacuum pumping system based on an ion pump. In this paper, the design features and the installation of the RI-production beam line at the KOMAC are given.

  3. Thermonuclear breakup reactions of light nuclei. II - Gamma-ray line production and other applications

    NASA Technical Reports Server (NTRS)

    Guessoum, Nidhal

    1989-01-01

    The main consequence of nuclear breakup reactions in high-temperature plasmas is shown to be to reduce the production of the gamma-ray lines, due to the breakup of these species at high temperature. Results of the emissivities of all the relevant gamma-ray lines are discussed. It is shown that the magnitude of the breakup effect on the line emissivities depends strongly on temperature, but more importantly on the plasma density and on the available time for the ion processes. Other effects considered include the production of neutrons (from the breakup of helium) and its consequences (such as the production of gamma rays from n-capture reactions and dynamical effects in accretion disk plasmas).

  4. Automation of Presentation Record Production Based on Rich-Media Technology Using SNT Petri Nets Theory

    PubMed Central

    Martiník, Ivo

    2015-01-01

    Rich-media describes a broad range of digital interactive media that is increasingly used in the Internet and also in the support of education. Last year, a special pilot audiovisual lecture room was built as a part of the MERLINGO (MEdia-rich Repository of LearnING Objects) project solution. It contains all the elements of the modern lecture room determined for the implementation of presentation recordings based on the rich-media technologies and their publication online or on-demand featuring the access of all its elements in the automated mode including automatic editing. Property-preserving Petri net process algebras (PPPA) were designed for the specification and verification of the Petri net processes. PPPA does not need to verify the composition of the Petri net processes because all their algebraic operators preserve the specified set of the properties. These original PPPA are significantly generalized for the newly introduced class of the SNT Petri process and agent nets in this paper. The PLACE-SUBST and ASYNC-PROC algebraic operators are defined for this class of Petri nets and their chosen properties are proved. The SNT Petri process and agent nets theory were significantly applied at the design, verification, and implementation of the programming system ensuring the pilot audiovisual lecture room functionality. PMID:26258164

  5. Automation of Presentation Record Production Based on Rich-Media Technology Using SNT Petri Nets Theory.

    PubMed

    Martiník, Ivo

    2015-01-01

    Rich-media describes a broad range of digital interactive media that is increasingly used in the Internet and also in the support of education. Last year, a special pilot audiovisual lecture room was built as a part of the MERLINGO (MEdia-rich Repository of LearnING Objects) project solution. It contains all the elements of the modern lecture room determined for the implementation of presentation recordings based on the rich-media technologies and their publication online or on-demand featuring the access of all its elements in the automated mode including automatic editing. Property-preserving Petri net process algebras (PPPA) were designed for the specification and verification of the Petri net processes. PPPA does not need to verify the composition of the Petri net processes because all their algebraic operators preserve the specified set of the properties. These original PPPA are significantly generalized for the newly introduced class of the SNT Petri process and agent nets in this paper. The PLACE-SUBST and ASYNC-PROC algebraic operators are defined for this class of Petri nets and their chosen properties are proved. The SNT Petri process and agent nets theory were significantly applied at the design, verification, and implementation of the programming system ensuring the pilot audiovisual lecture room functionality.

  6. Automated Coal-Mining System

    NASA Technical Reports Server (NTRS)

    Gangal, M. D.; Isenberg, L.; Lewis, E. V.

    1985-01-01

    Proposed system offers safety and large return on investment. System, operating by year 2000, employs machines and processes based on proven principles. According to concept, line of parallel machines, connected in groups of four to service modules, attacks face of coal seam. High-pressure water jets and central auger on each machine break face. Jaws scoop up coal chunks, and auger grinds them and forces fragments into slurry-transport system. Slurry pumped through pipeline to point of use. Concept for highly automated coal-mining system increases productivity, makes mining safer, and protects health of mine workers.

  7. Towards automated firearm identification based on high resolution 3D data: rotation-invariant features for multiple line-profile-measurement of firing pin shapes

    NASA Astrophysics Data System (ADS)

    Fischer, Robert; Vielhauer, Claus

    2015-03-01

    Understanding and evaluation of potential evidence, as well as evaluation of automated systems for forensic examinations currently play an important role within the domain of digital crime scene analysis. The application of 3D sensing and pattern recognition systems for automatic extraction and comparison of firearm related tool marks is an evolving field of research within this domain. In this context, the design and evaluation of rotation-invariant features for use on topography data play a particular important role. In this work, we propose and evaluate a 3D imaging system along with two novel features based on topography data and multiple profile-measurement-lines for automatic matching of firing pin shapes. Our test set contains 72 cartridges of three manufactures shot by six different 9mm guns. The entire pattern recognition workflow is addressed. This includes the application of confocal microscopy for data acquisition, preprocessing covers outlier handling, data normalization, as well as necessary segmentation and registration. Feature extraction involves the two introduced features for automatic comparison and matching of 3D firing pin shapes. The introduced features are called `Multiple-Circle-Path' (MCP) and `Multiple-Angle-Path' (MAP). Basically both features are compositions of freely configurable amounts of circular or straight path-lines combined with statistical evaluations. During the first part of evaluation (E1), we examine how well it is possible to differentiate between two 9mm weapons of the same mark and model. During second part (E2), we evaluate the discrimination accuracy regarding the set of six different 9mm guns. During the third part (E3), we evaluate the performance of the features in consideration of different rotation angles. In terms of E1, the best correct classification rate is 100% and in terms of E2 the best result is 86%. The preliminary results for E3 indicate robustness of both features regarding rotation. However, in future

  8. Regional differences in the effects of amphetamine withdrawal on dopamine dynamics in the striatum. Analysis of circadian patterns using automated on-line microdialysis.

    PubMed

    Paulson, P E; Robinson, T E

    1996-05-01

    The purpose of the study is to determine the relationship between behavioral symptoms of amphetamine withdrawal and the extracellular concentration of dopamine (DA) in the dorsolateral caudate nucleus and the nucleus accumbens across the entire light-dark cycle. This was accomplished using automated on-line microdialysis sampling in behaving rats. Animals were pretreated with escalating doses of d-amphetamine (or saline) over a 6-week period and then were withdrawn from amphetamine for 3, 7, or 28 days before testing. There were regional differences in the effects of amphetamine withdrawal on the concentrations of DA and DA metabolites in dialysate. Early during withdrawal (3 and 7 days), when animals showed postamphetamine withdrawal behavioral depression (nocturnal hypoactivity), there was a significant decrease in DA and DA metabolites in the dorsolateral caudate nucleus and a disruption in the normal circadian pattern of DA activity. In contrast, there was no effect of amphetamine withdrawal on DA dynamics in the nucleus accumbens. By 28 days after the discontinuation of amphetamine pretreatment, after basal DA in the caudate returned to normal, there was a significant increase in basal DA metabolism in both the caudate and the accumbens. This increase in DA metabolism may be related to the expression of sensitization, including a hypersensitivity to an amphetamine challenge. It is concluded that the role of the dorsal striatum in psychostimulant drug withdrawal syndromes deserves further consideration.

  9. 77 FR 53172 - Certain Lined Paper Products From India and the People's Republic of China: Continuation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... International Trade Administration Certain Lined Paper Products From India and the People's Republic of China... (the Department) that revocation of the antidumping duty (AD) orders on certain lined paper products (lined paper) from India and the People's Republic of China (PRC) would likely lead to continuation...

  10. On-line gas chromatographic analysis of higher alcohol synthesis products from syngas.

    PubMed

    Andersson, Robert; Boutonnet, Magali; Järås, Sven

    2012-07-20

    An on-line gas chromatographic (GC) system has been developed for rapid and accurate product analysis in catalytic conversion of syngas (a mixture of H₂ and CO) to alcohols, so called "higher alcohol synthesis (HAS)". Conversion of syngas to higher alcohols is an interesting second step in the route of converting coal, natural gas and possibly biomass to liquid alcohol fuel and chemicals. The presented GC system and method are developed for analysis of the products formed from syngas using alkali promoted MoS₂ catalysts, however it is not limited to these types of catalysts. During higher alcohol synthesis not only the wanted short alcohols (∼C₂-C₅) are produced, but also a great number of other products in smaller or greater amounts, they are mainly short hydrocarbons (olefins, paraffins, branched, non-branched), aldehydes, esters and ketones as well as CO₂, H₂O. Trace amounts of sulfur-containing compounds can also be found in the product effluent when sulfur-containing catalysts are used and/or sulfur-containing syngas is feed. In the presented GC system, most of them can be separated and analyzed within 60 min without the use of cryogenic cooling. Previously, product analysis in "higher alcohol synthesis" has in most cases been carried out partly on-line and partly off-line, where the light gases (gases at room temp) are analyzed on-line and liquid products (liquid at room temp) are collected in a trap for later analysis off-line. This method suffers from many drawbacks compared to a complete on-line GC system. In this paper an on-line system using an Agilent 7890 gas chromatograph equipped with two flame ionization detectors (FID) and a thermal conductivity detector (TCD), together with an Agilent 6890 with sulfur chemiluminescence dual plasma detector (SCD) is presented. A two-dimensional GC system with Deans switch (heart-cut) and two capillary columns (HP-FFAP and HP-Al₂O₃) was used for analysis of the organic products on the FIDs. Light

  11. The contribution of dissociative processes to the production of atomic lines in hydrogen plasmas

    NASA Technical Reports Server (NTRS)

    Kunc, J. A.

    1985-01-01

    The contribution of molecular dissociative processes to the production of atomic lines is considered for a steady-state hydrogen plasma. If the contribution of dissociative processes is dominant, a substantial simplification in plasma diagnostics can be achieved. Numerical calculations have been performed for the production of Balmer alpha, beta, and gamma lines in hydrogen plasmas with medium and large degrees of ionization (x greater than about 0.0001) and for electron temperatures of 5000-45,000 K and electron densities of 10 to the 10th to 10 to the 16th/cu cm.

  12. Mars Observer data production, transfer, and archival: The data production assembly line

    NASA Technical Reports Server (NTRS)

    Childs, David B.

    1993-01-01

    This paper describes the data production, transfer, and archival process designed for the Mars Observer Flight Project. It addresses the developmental and operational aspects of the archive collection production process. The developmental aspects cover the design and packaging of data products for archival and distribution to the planetary community. Also discussed is the design and development of a data transfer and volume production process capable of handling the large throughput and complexity of the Mars Observer data products. The operational aspects cover the main functions of the process: creating data and engineering products, collecting the data products and ancillary products in a central repository, producing archive volumes, validating volumes, archiving, and distributing the data to the planetary community.

  13. Development of at-line assay to monitor charge variants of MAbs during production.

    PubMed

    St Amand, M M; Ogunnaike, B A; Robinson, A S

    2014-01-01

    One major challenge currently facing the biopharmaceutical industry is to understand how MAb microheterogeneity affects therapeutic efficacy, potency, immunogenicity, and clearance. MAb micro-heterogeneity can result from post-translational modifications such as sialylation, galactosylation, C-terminal lysine cleavage, glycine amidation, and tryptophan oxidation, each of which can generate MAb charge variants; such heterogeneity can affect pharmacokinetics (PK) considerably. Implementation of appropriate on-line quality control strategies may help to regulate bioprocesses, thus enabling more homogenous material with desired post-translational modifications and PK behavior. However, one major restriction to implementation of quality control strategies is the availability of techniques for obtaining on-line or at-line measurements of these attributes. In this work, we describe the development of an at-line assay to separate MAb charge variants in near real-time, which could ultimately be used to implement on-line quality control strategies for MAb production. The assay consists of a 2D-HPLC method with sequential in-line Protein A and WCX-10 HPLC column steps. To perform the 2D-HPLC assay at-line, the two columns steps were integrated into a single method using a novel system configuration that allowed parallel flow over column 1 or column 2 or sequential flow from column 1 to column 2. A bioreactor system was also developed such that media samples could be removed automatically from bioreactor vessels during production and delivered to the 2D-HPLC for analysis. With this at-line HPLC assay, we have demonstrated that MAb microheterogeneity occurs throughout the cell cycle whether the host cell line is grown under different or the same nominal culture conditions.

  14. Multihormonal regulation of thyroglobulin production by the OVNIS 6H thyroid cell line.

    PubMed

    Aouani, A; Hovsépian, S; Fayet, G

    1988-02-01

    The hormonal regulation of thyroglobulin production has been studied using a clone of the ovine thyroid cell line: OVNIS 6H. 3 among the 6 hormones proposed for serum replacement are required for an optimal thyroglobulin production; insulin, hydrocortisone and thyrotropin. Insulin alone stimulates thyroglobulin production. The presence of insulin is also required to observe hydrocortisone and TSH stimulations. Newborn calf serum inhibits thyroglobulin production. The best conditions for optimal thyroglobulin expression and TSH responsiveness are obtained in serum-free medium supplemented with 5 micrograms/ml insulin, 100 nM hydrocortisone and 1 mU/ml TSH.

  15. Automated Visual Control System For Gob Feeders

    NASA Astrophysics Data System (ADS)

    Molesworth, Hugh; Vann, Tony

    1983-08-01

    The usable throughput and hence profitability of an automated glass bottle production line depends, amongst other factors, on the weight of glass in each bottle. Present techniques often rely on manual weighing of bottles on a sample basis with manual control of the feeder which forms the gobs from which the bottles are produced. Currently available automated weighing systems provide improved control although the weight measurement is still done only on a sample basis. All such weight measurement systems produce an undesirable delay before the bottle is safely available for weighing. This paper describes an automated visual gob weight control system which overcomes both of the above major limitations of existing control systems. The weight of every gob is calculated by visual scanning in free fall before the bottle is formed, allowing a fast and accurate closed-loop control system to be implemented.

  16. Automated identification of depsipeptide natural products by an informatic search algorithm.

    PubMed

    Skinnider, Michael A; Johnston, Chad W; Zvanych, Rostyslav; Magarvey, Nathan A

    2015-01-19

    Nonribosomal depsipeptides are a class of potent microbial natural products, which include several clinically approved pharmaceutical agents. Genome sequencing has revealed a large number of uninvestigated natural-product biosynthetic gene clusters. However, while novel informatic search methods to access these gene clusters have been developed to identify peptide natural products, depsipeptide detection has proven challenging. Herein, we present an improved version of our informatic search algorithm for natural products (iSNAP), which facilitates the detection of known and genetically predicted depsipeptides in complex microbial culture extracts. We validated this technology by identifying several depsipeptides from novel producers, and located a large number of novel depsipeptide gene clusters for future study. This approach highlights the value of chemoinformatic search methods for the discovery of genetically encoded metabolites by targeting specific areas of chemical space.

  17. Chemical analysis of soil and leachate from experimental wetland mesocosms lined with coal combustion products.

    PubMed

    Ahn, C; Mitsch, W J

    2001-01-01

    Small-scale (1 m2) wetland mesocosm experiments were conducted over two consecutive growing seasons to investigate the effects on soil and leachate chemistry of using a recycled coal combustion product as a liner. The coal combustion product used as a liner consisted of flue gas desulfurization (FGD) by-products and fly ash. This paper provides the chemical characteristics of mesocosm soil and leachate after 2 yr of experimentation. Arsenic, Ca, and pH were higher in FGD-lined mesocosm surface soil relative to unlined mesocosms. Aluminum was higher in the soils of unlined mesocosms relative to FGD-lined mesocosms. No significant difference of potentially phytotoxic B was observed between lined and unlined mesocosms in the soil. Higher pH, conductivity, and concentrations of Al, B, Ca, K, and S (SO4-S) were observed in leachate from lined mesocosms compared with unlined controls while Fe, Mg, and Mn were higher in leachate from unlined mesocosms. Concentrations of most elements analyzed in the leachate were below national primary and secondary drinking water standards after 2 yr of experimentation. Initially high pH and soluble salt concentrations measured in the leachate from the lined mesocosms may indicate the reason for early effects noted on the development of wetland vegetation in the mesocosms.

  18. The Development of an Interior Ballistic Model for Automated Continuous Propellant Production Control

    DTIC Science & Technology

    1979-01-01

    t . Other requests for this document aust be referred to Director, USA Ballistic Research Laboratory, ATTN: DROAR-TSB...r PROPELLANT LINE HOLDING i t i 1 * ! CHEMICAL AND PHYSICAL TESTS 1 1 s \\ PROCESS CONTROLLER 4 1 ._J j \\. ! * INTERIOR...X UJ —i < U CO >• BO ■ — CO CO LU U o UJ — V) — o QC a 3 i—i OC z o (J — a - X 1 F !/) a. CO — A 0 T ^ — UJ >■ e 1—

  19. Successful removal of Chlamydia pneumoniae from plateletpheresis products collected using automated leukoreduction hemapheresis techniques.

    PubMed

    Webley, Wilmore; Stuart, Elizabeth; Cirino, Frances; Cahill, Fran; Stec, Theresa; Andrzejewski, Chester

    2006-10-01

    Chlamydia pneumoniae (Cp) is an obligate intracellular pathogen associated with a variety of maladies. Best known for its involvement in community-acquired pneumonia outbreaks; the potential role of Cp in diverse illnesses is a topic of increasing interest and investigation. Previous studies suggested that white blood cells from normal blood donors harboring this agent may be eliminated through leukoreduction by filtration. Here we examine the ability and efficacy of apheresis-related leukoreduction for its effect on the carriage and potential infectivity of these organisms in the preparation of platelet products. Matched pre-apheresis peripheral blood (PB) samples and product samples obtained from healthy plateletpheresis donors were analyzed for the presence and potential infectivity of Cp organisms by direct smear inspection and tissue culture techniques. Antibody seroreactivity directed towards the organism was assessed using a solid phase immunoassay. Forty-eight percent of the donor blood samples exhibited elevated anti-Cp antibody titers (> or =200). Specimens from 31 (27%) and 34 (30%) of 115 plateletpheresis donors were positive for the presence of Cp organisms in their pre-apheresis PB samples when analyzed by direct smear examination and culture, respectively. Examination of the 115 post-leukodepleted plateletpheresis product samples revealed only two (1.7%) and one (0.009%) product(s) to be smear-positive and culture-positive, respectively. Certain plateletpheresis donors may harbor infectious Cp organisms in circulating WBC. Collections from such donors of apheresis platelet products using standard apheresis leukoreduction strategies appear successful in markedly decreasing or eliminating the organisms found in the final products.

  20. Effect of lignocellulosic composition and structure on the bioethanol production from different poplar lines.

    PubMed

    Duan, Xiaojian; Zhang, Changbo; Ju, Xuehai; Li, Qiongcui; Chen, Shouyi; Wang, Jingan; Liu, Zhongqi

    2013-07-01

    Branches from three transgenic poplar lines and their wild type line 107 were used to study the effect of lignocellulosic composition and structure on the production of glucose and ethanol. Experimental results showed that the transgenic line 18-1 had the high cellulose content and amorphous fibril structure. After poplar meals were pretreated with 10% NaOH and a mixture of hydrogen peroxide and acetic acid, their lateral order index decreased significantly. The highest glucose yield in enzymatic hydrolysis and ethanol yield from the substrate of 18-1 was much higher than that from feedstock of 107 by 192.7% and 108.7%, respectively. Scanning electron microscopy images confirmed that lignocellulose from the 18-1 could be destroyed by chemicals more easily than those from other lines. These results demonstrated that changing lignocellulose structure could be more effective on improving the digestibility and enzymatic hydrolysis of poplar biomass than increasing the cellulose content in biomass.

  1. Base Stock Policy in a Join-Type Production Line with Advanced Demand Information

    NASA Astrophysics Data System (ADS)

    Hiraiwa, Mikihiko; Tsubouchi, Satoshi; Nakade, Koichi

    Production control such as the base stock policy, the kanban policy and the constant work-in-process policy in a serial production line has been studied by many researchers. Production lines, however, usually have fork-type, join-type or network-type figures. In addition, in most previous studies on production control, a finished product is required at the same time as arrival of demand at the system. Demand information is, however, informed before due date in practice. In this paper a join-type (assembly) production line under base stock control with advanced demand information in discrete time is analyzed. The recursive equations for the work-in-process are derived. The heuristic algorithm for finding appropriate base stock levels of all machines at short time is proposed and the effect of advanced demand information is examined by simulation with the proposed algorithm. It is shown that the inventory cost can decreases with little backlogs by using the appropriate amount of demand information and setting appropriate base stock levels.

  2. Automated electrochemical synthesis and photoelectrochemical characterization of Zn1-xCo(x)O thin films for solar hydrogen production.

    PubMed

    Jaramillo, Thomas F; Baeck, Sung-Hyeon; Kleiman-Shwarsctein, Alan; Choi, Kyoung-Shin; Stucky, Galen D; McFarland, Eric W

    2005-01-01

    High-throughput electrochemical methods have been developed for the investigation of Zn1-xCo(x)O films for photoelectrochemical hydrogen production from water. A library of 120 samples containing 27 different compositions (0 automated serial electrochemical deposition. High-throughput photoelectrochemical screening revealed improved solar hydrogen production for the cobalt-doped films, with Zn0.956Co0.044O exhibiting a 4-fold improvement over pure ZnO with no external bias. Flat-band potential, bias-dependent photocurrent, and action spectra were also measured automatically with the high-throughput screening system. The 200-nm-thick films were subsequently characterized by numerous techniques, including SEM, XRD, XPS, and UV-vis, which show that the depositions are well-controlled. Zn/Co stoichiometry in the films was controlled by the ratio of the Zn and Co precursors in each deposition bath. All films exhibited the wurtzite structure typical of pure ZnO, and the Co2+ appears to substitute Zn2+, forming a single-phase solid solution. Band gaps of the solid solutions were systematically lower than the 3.2-eV band gap typical of ZnO.

  3. 75 FR 7563 - Certain Lined Paper Products from India: Notice of Final Results of Antidumping Duty...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-22

    ... Melissa Skinner from George McMahon titled ``Certain Lined Paper Products from India: Selection of... 776(a)(2)(A) and (C) and 776(b) of the Tariff Act of 1930, as amended (the Act), the Department... entries. Pursuant to 19 CFR 351.212(b)(1), we calculated importer-specific ad valorem duty...

  4. Second Generation Product Line Engineering Takes Hold in the DoD

    DTIC Science & Technology

    2014-01-01

    ill io ns Stovepipe w/o Consolidation Product Line - Industry Standard CPM Impact 1G PLM Cost Avoidance 1G PLM (Pre- Consolidation) 2G PLM Cost...Avoidance 2G PLM (CPM Impact) FY 48 42 36 3 24 18 12 6 on Urban Terrain (MOUT), Maneuver Combat Training Center (MCTC), instrumented live-fire range

  5. 40 CFR 1045.310 - How must I select engines for production-line testing?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false How must I select engines for production-line testing? 1045.310 Section 1045.310 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES...

  6. 40 CFR 1045.310 - How must I select engines for production-line testing?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false How must I select engines for production-line testing? 1045.310 Section 1045.310 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES...

  7. 40 CFR 1045.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false When must I test my production-line engines? 1045.301 Section 1045.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND...

  8. 40 CFR 1045.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false How must I prepare and test my production-line engines? 1045.305 Section 1045.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES...

  9. 40 CFR 1045.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false How must I prepare and test my production-line engines? 1045.305 Section 1045.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES...

  10. 40 CFR 1045.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false What production-line testing records must I send to EPA? 1045.345 Section 1045.345 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES...

  11. 40 CFR 1045.310 - How must I select engines for production-line testing?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false How must I select engines for production-line testing? 1045.310 Section 1045.310 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES...

  12. 40 CFR 1045.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false What production-line testing records must I send to EPA? 1045.345 Section 1045.345 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES...

  13. 40 CFR 1045.345 - What production-line testing records must I send to EPA?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false What production-line testing records must I send to EPA? 1045.345 Section 1045.345 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES...

  14. 40 CFR 1045.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false When must I test my production-line engines? 1045.301 Section 1045.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND...

  15. 40 CFR 1045.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false How must I prepare and test my production-line engines? 1045.305 Section 1045.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES...

  16. 40 CFR 1045.310 - How must I select engines for production-line testing?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 34 2013-07-01 2013-07-01 false How must I select engines for production-line testing? 1045.310 Section 1045.310 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES...

  17. 40 CFR 1045.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false How must I prepare and test my production-line engines? 1045.305 Section 1045.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES...

  18. 40 CFR 1045.305 - How must I prepare and test my production-line engines?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false How must I prepare and test my production-line engines? 1045.305 Section 1045.305 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES...

  19. 40 CFR 1045.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 34 2012-07-01 2012-07-01 false When must I test my production-line engines? 1045.301 Section 1045.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND...

  20. 40 CFR 1045.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false When must I test my production-line engines? 1045.301 Section 1045.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND...

  1. 40 CFR 1045.301 - When must I test my production-line engines?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 33 2014-07-01 2014-07-01 false When must I test my production-line engines? 1045.301 Section 1045.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND...

  2. Using the scanning electron microscope on the production line to assure quality semiconductors

    NASA Technical Reports Server (NTRS)

    Adolphsen, J. W.; Anstead, R. J.

    1972-01-01

    The use of the scanning electron microscope to detect metallization defects introduced during batch processing of semiconductor devices is discussed. A method of determining metallization integrity was developed which culminates in a procurement specification using the scanning microscope on the production line as a quality control tool. Batch process control of the metallization operation is monitored early in the manufacturing cycle.

  3. Industrialization of lipid nanoparticles: From laboratory-scale to large-scale production line.

    PubMed

    Hu, Caibiao; Qian, Airui; Wang, Qiang; Xu, Feng; He, Yi; Xu, Jing; Xia, Yongchang; Xia, Qiang

    2016-12-01

    This work aimed at developing a large-scale modular production line, which referred to coenzyme Q10 loaded-NLC as well as its continuous and scalable emulsification and homogenization process. The production line exhibited good control over the emulsification and homogenization process and enabled the particle size of NLC below 210nm at a throughput of 25kg/h (for lipid solution at a flow rate of 0.4kg/min). Among the several process parameters investigated, the size of the NLC was mainly influenced by the pre-emulsification temperature, homogenization pressure and homogenization. Suitable emulsification temperature (70°C), homogenization pressure (600, 800bar), and homogenization cycle (3, 4cycles) resulted in relatively smaller particles. These results proved that coenzyme Q10, a model active, had been successfully loaded into the NLC. Meanwhile, the large-scale production line can be effectively applied for continuous and modular production of NLC. The line had modern networking features-essential in the Internet age-and a modular design that was easily modified and upgraded. In addition, the long-term stability over 6month was monitored at 30°C and at 40°C to assess a potential effect of the laboratory scale and large scale on stability. All batches at room temperature and below were stable, and only a negligible increase in size was observed.

  4. CONSTRAINING JET PRODUCTION SCENARIOS BY STUDIES OF NARROW-LINE RADIO GALAXIES

    SciTech Connect

    Sikora, Marek; Stasinska, Grazyna; Koziel-Wierzbowska, Dorota; Madejski, Greg M.; Asari, Natalia V.

    2013-03-01

    We study a large sample of narrow-line radio galaxies (NLRGs) with extended radio structures. Using 1.4 GHz radio luminosities L {sub 1.4}, narrow optical emission line luminosities L {sub [OIII]} and L{sub H{sub {alpha}}}, as well as black hole masses M {sub BH} derived from stellar velocity dispersions measured from the optical spectra obtained with the Sloan Digital Sky Survey, we find that (1) NLRGs cover about four decades of the Eddington ratio, {lambda} {identical_to} L {sub bol}/L {sub Edd}{proportional_to}L {sub line}/M {sub BH}; (2) L {sub 1.4}/M {sub BH} strongly correlates with {lambda}; and (3) radio loudness, R{identical_to}L{sub 1.4}/L{sub line}, strongly anti-correlates with {lambda}. A very broad range of the Eddington ratio indicates that the parent population of NLRGs includes both radio-loud quasars (RLQs) and broad-line radio galaxies (BLRGs). The correlations they obey and their high jet production efficiencies favor a jet production model which involves the so-called magnetically choked accretion scenario. In this model, production of the jet is dominated by the Blandford-Znajek mechanism, and the magnetic fields in the vicinity of the central black hole are confined by the ram pressure of the accretion flow. Since large net magnetic flux accumulated in central regions of the accretion flow required by the model can take place only via geometrically thick accretion, we speculate that the massive, 'cold' accretion events associated with luminous emission-line active galactic nucleus can be accompanied by an efficient jet production only if preceded by a hot, very sub-Eddington accretion phase.

  5. An On-Line Integrated Control System for Reducing Coal Costs and Coal-Related Emissions: Coal Blend Automation System (CBAS)

    SciTech Connect

    Maxson, J. Andrew; Sehgal, Randhir; Shea, Suzanne

    1997-12-31

    In 1995, TransAlta Utilities and Dairyland Power agreed to participate in a project funded by the U.S. Department of Energy to demonstrate a power plant optimization software product developed by Praxis Engineers, Inc. The product, the Plant Environmental and Cost Optimization System (PECOS{trademark}), considers the power plant in its entirety from coal receipts and yard management to solid by-products and emissions. Its basic goal is to minimize the controllable costs of power generation. PECOS does so by performing an on-line analysis of all operations and their co-optimization to achieve a minimum generation cost. The software acts as an advisor to the plant operators and computes settings that achieve this goal. A general schematic of PECOS is given.

  6. Source term analysis for a criticality accident in metal production line glove boxes

    SciTech Connect

    Nguyen, D.H.

    1991-06-01

    A recent development in criticality accident analysis is the deterministic calculations of the transport of fission products and actinides through the barriers of the physical facility. The knowledge of the redistribution of the materials inside the facility will help determine the reentry and clean-up procedures. The amount of radioactive materials released to the environment is the source term for dispersion calculations. We have used an integrated computer model to determine the release of fission products to the environment from a hypothetical criticality event in a glove box of the metal production line (MPL) at the Lawrence Livermore National Laboratory (LLNL).

  7. Production of higher quality bio-oils by in-line esterification of pyrolysis vapor

    SciTech Connect

    Hilten, Roger Norris; Das, Keshav; Kastner, James R; Bibens, Brian P

    2014-12-02

    The disclosure encompasses in-line reactive condensation processes via vapor phase esterification of bio-oil to decease reactive species concentration and water content in the oily phase of a two-phase oil, thereby increasing storage stability and heating value. Esterification of the bio-oil vapor occurs via the vapor phase contact and subsequent reaction of organic acids with ethanol during condensation results in the production of water and esters. The pyrolysis oil product can have an increased ester content and an increased stability when compared to a condensed pyrolysis oil product not treated with an atomized alcohol.

  8. Expert systems for automated maintenance of a Mars oxygen production system

    NASA Technical Reports Server (NTRS)

    Ash, Robert L.; Huang, Jen-Kuang; Ho, Ming-Tsang

    1989-01-01

    A prototype expert system was developed for maintaining autonomous operation of a Mars oxygen production system. Normal operation conditions and failure modes according to certain desired criteria are tested and identified. Several schemes for failure detection and isolation using forward chaining, backward chaining, knowledge-based and rule-based are devised to perform several housekeeping functions. These functions include self-health checkout, an emergency shut down program, fault detection and conventional control activities. An effort was made to derive the dynamic model of the system using Bond-Graph technique in order to develop the model-based failure detection and isolation scheme by estimation method. Finally, computer simulations and experimental results demonstrated the feasibility of the expert system and a preliminary reliability analysis for the oxygen production system is also provided.

  9. Biomimetic Assembly Lines Producing Natural Product Analogs: Strategies from a Versatile Manifold to Skeletally Diverse Scaffolds.

    PubMed

    Oguri, Hiroki

    2016-02-01

    Biosynthetic assembly lines have evolved in nature, adopting divergent processes to produce a vast number of secondary metabolites. Inspired by these biogenetic processes, this account introduces recent investigations by my research group to formulate a synthetic strategy for establishing a biomimetic assembly line. With the aim not only to construct natural product-relevant scaffolds within 5-7 steps, but also to systematically diversify skeletal and stereochemical properties and functional groups, divergent synthetic processes exploiting a versatile manifold have been developed. This approach allows for cost-effective production of skeletally diverse and biologically active natural product analogs inaccessible by other means. Discovery of several lead candidates for a neglected tropical disease is a proof-of-concept of this synthetic approach.

  10. Biomimetic Assembly Lines Producing Natural Product Analogs: Strategies from a Versatile Manifold to Skeletally Diverse Scaffolds.

    PubMed

    Oguri, Hiroki

    2016-04-01

    Biosynthetic assembly lines have evolved in nature, adopting divergent processes to produce a vast number of secondary metabolites. Inspired by these biogenetic processes, this account introduces recent investigations by my research group to formulate a synthetic strategy for establishing a biomimetic assembly line. With the aim not only to construct natural product-relevant scaffolds within 5-7 steps, but also to systematically diversify skeletal and stereochemical properties and functional groups, divergent synthetic processes exploiting a versatile manifold have been developed. This approach allows for cost-effective production of skeletally diverse and biologically active natural product analogs inaccessible by other means. Discovery of several lead candidates for a neglected tropical disease is a proof-of-concept of this synthetic approach.

  11. Automated product recovery in a HG-196 photochemical isotope separation process

    DOEpatents

    Grossman, Mark W.; Speer, Richard

    1992-01-01

    A method of removing deposited product from a photochemical reactor used in the enrichment of .sup.196 Hg has been developed and shown to be effective for rapid re-cycling of the reactor system. Unlike previous methods relatively low temperatures are used in a gas and vapor phase process of removal. Importantly, the recovery process is understood in a quantitative manner so that scaling design to larger capacity systems can be easily carried out.

  12. Automated Job Controller for Clouds and the Earth's Radiant Energy System (CERES) Production Processing

    NASA Astrophysics Data System (ADS)

    Gleason, J. L.; Hillyer, T. N.

    2011-12-01

    Clouds and the Earth's Radiant Energy System (CERES) is one of NASA's highest priority Earth Observing System (EOS) scientific instruments. The CERES science team will integrate data from the CERES Flight Model 5 (FM5) on the NPOESS Preparatory Project (NPP) in addition to the four CERES scanning instrument on Terra and Aqua. The CERES production system consists of over 75 Product Generation Executives (PGEs) maintained by twelve subsystem groups. The processing chain fuses CERES instrument observations with data from 19 other unique sources. The addition of FM5 to over 22 instrument years of data to be reprocessed from flight models 1-4 creates a need for an optimized production processing approach. This poster discusses a new approach, using JBoss and Perl to manage job scheduling and interdependencies between PGEs and external data sources. The new optimized approach uses JBoss to serve handler servlets which regulate PGE-level job interdependencies and job completion notifications. Additional servlets are used to regulate all job submissions from the handlers and to interact with the operator. Perl submission scripts are used to build Process Control Files and to interact directly with the operating system and cluster scheduler. The result is a reduced burden on the operator by algorithmically enforcing a set of rules that determine the optimal time to produce data products with the highest integrity. These rules are designed on a per PGE basis and periodically change. This design provides the means to dynamically update PGE rules at run time and increases the processing throughput by using an event driven controller. The immediate notification of a PGE's completion (an event) allows successor PGEs to launch at the proper time with minimal start up latency, thereby increasing computer system utilization.

  13. An Automated Patient Classification System for Staffing, Billing and Productivity Measurement

    PubMed Central

    Budd, Marjorie; Blaufuss, Judy; Propotnik, Toni; Maynard, Jan; Klingle, Connie; Pryor, Allan

    1988-01-01

    Nursing administrators across the country are developing methods to identify nursing department costs and revenue. A patient classification system driven by computerized nurses notes was developed at LDS Hospital as part of the hospital information system. This system is used to determine appropriates staffing on all nursing units and to bill patients directly for nursing care. The data is also used to measure nursing department productivity.

  14. Automated product recovery in a Hg-196 photochemical isotope separation process

    DOEpatents

    Grossman, M.W.; Speer, R.

    1992-07-21

    A method of removing deposited product from a photochemical reactor used in the enrichment of [sup 196]Hg has been developed and shown to be effective for rapid re-cycling of the reactor system. Unlike previous methods relatively low temperatures are used in a gas and vapor phase process of removal. Importantly, the recovery process is understood in a quantitative manner so that scaling design to larger capacity systems can be easily carried out. 2 figs.

  15. Automated on-line column-switching HPLC-MS/MS method with peak focusing for the determination of nine environmental phenols in urine.

    PubMed

    Ye, Xiaoyun; Kuklenyik, Zsuzsanna; Needham, Larry L; Calafat, Antonia M

    2005-08-15

    We developed a method using isotope dilution on-line solid-phase extraction (SPE) coupled to high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) for the determination in urine of nine environmental phenolic compounds: Bisphenol A; 4-tert-octylphenol; o-phenylphenol; 2,4-dichlorophenol; 2,5-dichlorophenol; 2,4,5-trichlorophenol; 2,4,6-trichlorophenol; benzophenone-3 (2-hydroxy-4-metoxybenzophenone); and triclosan (2,4,4'-trichloro-2'-hydroxyphenyl ether). A unique fully automated column-switching system, constructed using 1 autosampler, 2 HPLC pumps, and a 10-port switching valve, was designed to allow for concurrent SPE-HPLC operation with peak focusing. The phenols present in 100 microL of urine were retained and concentrated on a C18 reversed-phase size-exclusion SPE column. Then, the phenols were "back-eluted" from the SPE column and diluted through a mixing Tee before being separated from other urine matrix components using a pair of monolithic HPLC columns. The phenols were detected by negative ion-atmospheric pressure chemical ionization-MS/MS. The efficient preconcentration of the phenols by the SPE column, analyte peak focusing by the dilution, and minimal ion suppression in the LC/MS interface by the buffer-free mobile phases resulted in limits of detection as low as 0.1-0.4 ng/mL for most analytes. The method was validated on spiked pooled urine samples and on urine samples from 30 adults with no known occupational exposure to environmental phenols. The method can be used for quick and accurate analysis of large numbers of samples in epidemiologic studies for assessing the prevalence of human exposure to environmental phenols.

  16. Highly sensitive routine method for urinary 3-hydroxybenzo[a]pyrene quantitation using liquid chromatography-fluorescence detection and automated off-line solid phase extraction.

    PubMed

    Barbeau, Damien; Maître, Anne; Marques, Marie

    2011-03-21

    Many workers and also the general population are exposed to polycyclic aromatic hydrocarbons (PAHs), and benzo[a]pyrene (BaP) was recently classified as carcinogenic for humans (group 1) by the International Agency for Research on Cancer. Biomonitoring of PAHs exposure is usually performed by urinary 1-hydroxypyrene (1-OHP) analysis. 1-OHP is a metabolite of pyrene, a non-carcinogenic PAH. In this work, we developed a very simple but highly sensitive analytical method of quantifying one urinary metabolite of BaP, 3-hydroxybenzo[a]pyrene (3-OHBaP), to evaluate carcinogenic PAHs exposure. After hydrolysis of 10 mL urine for two hours and concentration by automated off-line solid phase extraction, the sample was injected in a column-switching high-performance liquid chromatography fluorescence detection system. The limit of quantification was 0.2 pmol L(-1) (0.05 ng L(-1)) and the limit of detection was estimated at 0.07 pmol L(-1) (0.02 ng L(-1)). Linearity was established for 3-OHBaP concentrations ranging from 0.4 to 74.5 pmol L(-1) (0.1 to 20 ng L(-1)). Relative within-day standard deviation was less than 3% and relative between-day standard deviation was less than 4%. In non-occupationally exposed subjects, median concentrations for smokers compared with non-smokers were 3.5 times higher for 1-OHP (p<0.001) and 2 times higher for 3-OHBaP (p<0.05). The two urinary biomarkers were correlated in smokers (ρ=0.636; p<0.05; n=10) but not in non-smokers (ρ=0.09; p>0.05; n=21).

  17. Automated determination of venlafaxine in human plasma by on-line SPE-LC-MS/MS. Application to a bioequivalence study.

    PubMed

    Suenaga, Eunice Mayumi; Ifa, Demian R; Cruz, Alessandro Carvalho; Pereira, Renata; Abib, Eduardo; Tominga, Mineko; Nakaie, Clovis Ryuichi

    2009-02-01

    A new automated SPE-LC-ESI-MS/MS method was developed and validated to quantify venlafaxine in human plasma using fluoxetine as an internal standard. The analytes were automatically extracted from plasma by C18 SPE cartridges, separated on a C8 RP column and analyzed by MS in the multiple reaction-monitoring (MRM) mode. The method has a chromatographic run time of 4.0 min and a linear calibration curve over the range of 0.25-200 ng/mL (r >0.997). The between-run precisions, based on the percent RSD for replicate quality controls (0.75; 80, and 200 ng/mL), were < 8.5% for all concentrations. The between-run accuracies, based on the percent relative error, were < 4.0%. This method was successfully employed in a bioequivalence study of two venlafaxine capsule formulations (test formulation from Eurofarma (Brazil) and Efexor XR, reference formulation, from Wyeth-Whitehall, Brazil) in 48 healthy volunteers of both sexes who received a single 150 mg dose of each formulation. More than 3000 samples were analyzed eliminating the analyst's exposure to hazardous organic solvents normally employed in off-line liquid-liquid extractions. The 90% confidence interval (CI) of the individual ratio geometric mean for Test/Reference was 91.6-103.4% for AUC(0-48 h) and 102.2-112.6% for C(max). Since both 90% CI for AUC(0-48 h) and C(max) were included in the 80-125% interval proposed by the US Food and Drug Administration (FDA) and the Brazilian National Health Surveillance Agency (ANVISA), the test formulation was considered bioequivalent to Efexor XR according to both the rate and extent of absorption.

  18. Fully automated precision predictions for heavy neutrino production mechanisms at hadron colliders

    NASA Astrophysics Data System (ADS)

    Degrande, Céline; Mattelaer, Olivier; Ruiz, Richard; Turner, Jessica

    2016-09-01

    Motivated by TeV-scale neutrino mass models, we propose a systematic treatment of heavy neutrino (N ) production at hadron colliders. Our simple and efficient modeling of the vector boson fusion (VBF) W±γ →N ℓ± and N ℓ±+nj signal definitions resolve collinear and soft divergences that have plagued past studies, and is applicable to other color-singlet processes, e.g., associated Higgs (W±h), sparticle (ℓ˜±νℓ˜), and charged Higgs (h±±h∓) production. We present, for the first time, a comparison of all leading N production modes, including both gluon fusion (GF) g g →Z*/h*→N νℓ (-) and VBF. We obtain fully differential results up to next-to-leading order (NLO) in QCD accuracy using a Monte Carlo tool chain linking feynrules, nloct, and madgraph5_amc@nlo. Associated model files are publicly available. At the 14 TeV LHC, the leading order GF rate is small and comparable to the NLO N ℓ±+1 j rate; at a future 100 TeV Very Large Hadron Collider, GF dominates for mN=300 - 1500 GeV , beyond which VBF takes the lead.

  19. Towards automation in protein digestion: Development of a monolithic trypsin immobilized reactor for highly efficient on-line digestion and analysis.

    PubMed

    Naldi, Marina; Černigoj, Urh; Štrancar, Ales; Bartolini, Manuela

    2017-05-15

    Reducing experimental variability, limiting contamination and increasing automation are essential goals in the development of reliable analytical platforms for mass spectrometry (MS)-based proteomics. In this work novel trypsin-based monolithic immobilized enzyme reactors (tryp-IMERs), obtained by covalent immobilization on convective interaction media (CIMac™) analytical columns (5mm×5.2mm I.D.), were developed. Notwithstanding the small dimensions, column format allowed the insertion in common high performance liquid chromatography (HPLC) systems, thus avoiding the use of expensive micro- or nano-platforms. Monolith pore diameter and surface chemistry were optimized to achieve high digestion efficiency even with high molecular weight proteins and to avoid protein/peptide adsorption, peak broadening and sample loss. A full characterization of the tryp-IMERs was undertaken to select the best protocol for preparation and type of trypsin. Optimization of the operational and storage conditions was carried out by an off-line approach. On-line studies were performed by setting a multidimensional analytical platform, which included the tryp-IMER, a trapping column, an analytical C4 column and a high resolution hybrid mass spectrometer (ESI-Q-TOF). In the optimized conditions rapid protein digestion (90±9s), high protein coverage (≥60%) and high score values were achieved for five selected sample proteins (cytochrome c, myoglobin and albumins from different sources) differing in molecular size, isoelectric point and accessibility to cleavage sites as well as for a protein mixture of 200ng. The best performing tryp-IMERs showed high sensitivity down to the pmole level. The platform also resulted suitable for the analysis of high-molecular weight proteins such as a pool of human immunoglobulins G (hIgG) and for the high molecular weight fraction of human plasma proteins, which were digested in less than two minutes to an extent similar to that achieved by overnight

  20. A new algorithm for off-line automated emboli detection based on the pseudo-wigner power distribution and the dual gate TCD technique.

    PubMed

    Mess, W H; Titulaer, B M; Ackerstaff, R G

    2000-03-01

    Research on microembolic signals (MES) using the dual-gate technique has shown promising results, when the time difference (Deltat) of a MES in two sample volumes (SVs) placed serially has been measured manually. On the other hand, the computerized discrimination of MES and artefacts has been reported not to be superior to algorithms based on a single SV. Therefore, a dataset containing MES as well as four types of artefacts was made to test a preliminary version of a new algorithm for automated emboli detection. We monitored 20 patients during carotid endarterectomy (n = 17) and heart surgery (n = 3). Two transcranial Doppler (TCD) signals with a partial overlap of the SVs were recorded online and analysed off-line with an algorithm based on three consecutive steps: 1. Is there an intensity increase in both channels (64-point FFT; 50% overlap)? 2. What is the expected time difference (Deltat), with the velocity measured in channel 1 as the calculation basis? 3. What is the 'exact' Deltat (pseudo-Wigner power function)? Two human experts decided whether a signal was a MES or belonged to one of the four artefact groups. Of a total of 97 MES, 28% (n = 27) could not be detected in the distal channel. Thus, 72% (n = 70) of the MES were present in both channels and could be analysed based on the abovementioned criteria. Of these 70 MES, 87% (n = 61) were correctly identified off-line. We assessed artefact rejection for four different types of artefacts: changes of TCD settings, probe movement, low flow artefacts and electrocautery. The reliability of artefact rejection was 98% for setting changes (n = 382), 96% for probe movement (n = 477) and 98% for low flow artefacts (n = 91), but only 68% for electrocautery (n = 264). These preliminary results are promising, but need careful interpretation: 28% of the MES were not detectable in the distal SV, probably due to a poor signal-to-noise ratio (SNR) and anatomical restrictions. Electrocautery signals were insufficiently

  1. Gamma-ray line emission from 7Li and 7Be production by cosmic-rays

    NASA Astrophysics Data System (ADS)

    Tatischeff, V.; Thibaud, J.-P.; Kiener, J.; Cassé, M.; Vangioni-Flam, E.

    2001-09-01

    We calculate the total γ-ray line emission at ~450 keV that accompanies 7Li and 7Be production by cosmic-ray interactions, including the delayed line emission at 0.478 MeV from 7Be radioactive decay. We present a new γ-ray spectroscopic test which has the potential to give direct information on the nature of the interstellar regions into which 7Be ions propagate and decay. Finally, we evaluate the intensity of the predicted diffuse emission from the central radian of the Galaxy.

  2. Automated solar module assembly line

    NASA Technical Reports Server (NTRS)

    Bycer, M.

    1980-01-01

    The solar module assembly machine which Kulicke and Soffa delivered under this contract is a cell tabbing and stringing machine, and capable of handling a variety of cells and assembling strings up to 4 feet long which then can be placed into a module array up to 2 feet by 4 feet in a series of parallel arrangement, and in a straight or interdigitated array format. The machine cycle is 5 seconds per solar cell. This machine is primarily adapted to 3 inch diameter round cells with two tabs between cells. Pulsed heat is used as the bond technique for solar cell interconnects. The solar module assembly machine unloads solar cells from a cassette, automatically orients them, applies flux and solders interconnect ribbons onto the cells. It then inverts the tabbed cells, connects them into cell strings, and delivers them into a module array format using a track mounted vacuum lance, from which they are taken to test and cleaning benches prior to final encapsulation into finished solar modules. Throughout the machine the solar cell is handled very carefully, and any contact with the collector side of the cell is avoided or minimized.

  3. Automated solar module assembly line

    NASA Astrophysics Data System (ADS)

    Bycer, M.

    1980-08-01

    The solar module assembly machine which Kulicke and Soffa delivered under this contract is a cell tabbing and stringing machine, and capable of handling a variety of cells and assembling strings up to 4 feet long which then can be placed into a module array up to 2 feet by 4 feet in a series of parallel arrangement, and in a straight or interdigitated array format. The machine cycle is 5 seconds per solar cell. This machine is primarily adapted to 3 inch diameter round cells with two tabs between cells. Pulsed heat is used as the bond technique for solar cell interconnects. The solar module assembly machine unloads solar cells from a cassette, automatically orients them, applies flux and solders interconnect ribbons onto the cells. It then inverts the tabbed cells, connects them into cell strings, and delivers them into a module array format using a track mounted vacuum lance, from which they are taken to test and cleaning benches prior to final encapsulation into finished solar modules. Throughout the machine the solar cell is handled very carefully, and any contact with the collector side of the cell is avoided or minimized.

  4. Automation in Immunohematology

    PubMed Central

    Bajpai, Meenu; Kaur, Ravneet; Gupta, Ekta

    2012-01-01

    There have been rapid technological advances in blood banking in South Asian region over the past decade with an increasing emphasis on quality and safety of blood products. The conventional test tube technique has given way to newer techniques such as column agglutination technique, solid phase red cell adherence assay, and erythrocyte-magnetized technique. These new technologies are adaptable to automation and major manufacturers in this field have come up with semi and fully automated equipments for immunohematology tests in the blood bank. Automation improves the objectivity and reproducibility of tests. It reduces human errors in patient identification and transcription errors. Documentation and traceability of tests, reagents and processes and archiving of results is another major advantage of automation. Shifting from manual methods to automation is a major undertaking for any transfusion service to provide quality patient care with lesser turnaround time for their ever increasing workload. This article discusses the various issues involved in the process. PMID:22988378

  5. Metrology automation reliability

    NASA Astrophysics Data System (ADS)

    Chain, Elizabeth E.

    1996-09-01

    At Motorola's MOS-12 facility automated measurements on 200- mm diameter wafers proceed in a hands-off 'load-and-go' mode requiring only wafer loading, measurement recipe loading, and a 'run' command for processing. Upon completion of all sample measurements, the data is uploaded to the factory's data collection software system via a SECS II interface, eliminating the requirement of manual data entry. The scope of in-line measurement automation has been extended to the entire metrology scheme from job file generation to measurement and data collection. Data analysis and comparison to part specification limits is also carried out automatically. Successful integration of automated metrology into the factory measurement system requires that automated functions, such as autofocus and pattern recognition algorithms, display a high degree of reliability. In the 24- hour factory reliability data can be collected automatically on every part measured. This reliability data is then uploaded to the factory data collection software system at the same time as the measurement data. Analysis of the metrology reliability data permits improvements to be made as needed, and provides an accurate accounting of automation reliability. This reliability data has so far been collected for the CD-SEM (critical dimension scanning electron microscope) metrology tool, and examples are presented. This analysis method can be applied to such automated in-line measurements as CD, overlay, particle and film thickness measurements.

  6. Productivity and fishing pressure drive variability in fish parasite assemblages of the Line Islands, equatorial Pacific.

    PubMed

    Wood, Chelsea L; Baum, Julia K; Reddy, Sheila M W; Trebilco, Rowan; Sandin, Stuart A; Zgliczynski, Brian J; Briggs, Amy A; Micheli, Fiorenza

    2015-05-01

    Variability in primary productivity and fishing pressure can shape the abundance, species composition, and diversity of marine life. Though parasites comprise nearly half of marine species, their responses to these important forces remain little explored. We quantified parasite assemblages at two spatial scales, across a gradient in productivity and fishing pressure that spans six coral islands of the Line Islands archipelago and within the largest Line Island, Kiritimati, which experiences a west-to-east gradient in fishing pressure and upwelling-driven productivity. In the across-islands data set, we found that increasing productivity was correlated with increased parasite abundance overall, but that the effects of productivity differed among parasite groups. Trophically transmitted parasites increased in abundance with increasing productivity, but directly transmitted parasites did not exhibit significant changes. This probably arises because productivity has stronger effects on the abundance of the planktonic crustaceans and herbivorous snails that serve as the intermediate hosts of trophically transmitted parasites than on the higher-trophic level fishes that are the sole hosts of directly transmitted parasites. We also found that specialist parasites increased in response to increasing productivity, while generalists did not, possibly because specialist parasites tend to be more strongly limited by host availability than are generalist parasites. After the effect of productivity was controlled for, fishing was correlated with decreases in the abundance of trophically transmitted parasites, while directly transmitted parasites appeared to track host density; we observed increases in the abundance of parasites using hosts that experienced fishing-driven compensatory increases in abundance. The within-island data set confirmed these patterns for the combined effects of productivity and fishing on parasite abundance, suggesting that our conclusions are robust

  7. Automated Production of Test Data to Aid Integration of Gaia First Look Monitor Software

    NASA Astrophysics Data System (ADS)

    Cross, N.; Heyrovsky, A.

    2012-09-01

    Gaia is an ESA cornerstone mission, expected to launch in 2013. Parallaxes for 1 billion stars with up to 10 μas accuracy will be measured using Gaia. Data from Gaia will be processed by 3 pipelines: Initial Data Treatment First Look (IDT-FL), Astrometric Global Iterative Solution (AGIS) and Intermediate Data Update (IDU). IDT-FL runs daily, to process the incoming data and match them to the existing catalogue. FL does sanity checks on the IDT output and issues alerts for any problems. In this paper we describe the production of test data and and tests designed to help develop Detailed First Look Monitor (DFLM) code for FL. These diagnostic tests help to bridge the gap between simple JUnit tests and the full IDT-FL integration tests, by testing the complex setup and infrastructure of the DFLM diagnostics and analyses.

  8. Visual Perception-Based Statistical Modeling of Complex Grain Image for Product Quality Monitoring and Supervision on Assembly Production Line

    PubMed Central

    Chen, Qing; Xu, Pengfei; Liu, Wenzhong

    2016-01-01

    Computer vision as a fast, low-cost, noncontact, and online monitoring technology has been an important tool to inspect product quality, particularly on a large-scale assembly production line. However, the current industrial vision system is far from satisfactory in the intelligent perception of complex grain images, comprising a large number of local homogeneous fragmentations or patches without distinct foreground and background. We attempt to solve this problem based on the statistical modeling of spatial structures of grain images. We present a physical explanation in advance to indicate that the spatial structures of the complex grain images are subject to a representative Weibull distribution according to the theory of sequential fragmentation, which is well known in the continued comminution of ore grinding. To delineate the spatial structure of the grain image, we present a method of multiscale and omnidirectional Gaussian derivative filtering. Then, a product quality classifier based on sparse multikernel–least squares support vector machine is proposed to solve the low-confidence classification problem of imbalanced data distribution. The proposed method is applied on the assembly line of a food-processing enterprise to classify (or identify) automatically the production quality of rice. The experiments on the real application case, compared with the commonly used methods, illustrate the validity of our method. PMID:26986726

  9. Visual Perception-Based Statistical Modeling of Complex Grain Image for Product Quality Monitoring and Supervision on Assembly Production Line.

    PubMed

    Liu, Jinping; Tang, Zhaohui; Zhang, Jin; Chen, Qing; Xu, Pengfei; Liu, Wenzhong

    2016-01-01

    Computer vision as a fast, low-cost, noncontact, and online monitoring technology has been an important tool to inspect product quality, particularly on a large-scale assembly production line. However, the current industrial vision system is far from satisfactory in the intelligent perception of complex grain images, comprising a large number of local homogeneous fragmentations or patches without distinct foreground and background. We attempt to solve this problem based on the statistical modeling of spatial structures of grain images. We present a physical explanation in advance to indicate that the spatial structures of the complex grain images are subject to a representative Weibull distribution according to the theory of sequential fragmentation, which is well known in the continued comminution of ore grinding. To delineate the spatial structure of the grain image, we present a method of multiscale and omnidirectional Gaussian derivative filtering. Then, a product quality classifier based on sparse multikernel-least squares support vector machine is proposed to solve the low-confidence classification problem of imbalanced data distribution. The proposed method is applied on the assembly line of a food-processing enterprise to classify (or identify) automatically the production quality of rice. The experiments on the real application case, compared with the commonly used methods, illustrate the validity of our method.

  10. Automated damage test facilities for materials development and production optic quality assurance at Lawrence Livermore National Laboratory

    SciTech Connect

    Battersby, C; Dickson, R; Jennings, R; Kimmons, J; Kozlowski, M R; Maricle, S; Mouser, R; Runkel, M; Schwartz, S; Sheehan, L M; Weinzapfel, C

    1998-12-22

    The Laser Program at LLNL has developed automated facilities for damage testing optics up to 1 meter in diameter. The systems were developed to characterize the statistical distribution of localized damage performance across large-aperture National Ignition Facility optics. Full aperture testing is a key component of the quality assurance program for several of the optical components. The primary damage testing methods used are R:1 mapping and raster scanning. Automation of these test methods was required to meet the optics manufacturing schedule. The automated activities include control and diagnosis of the damage-test laser beam as well as detection and characterization of damage events.

  11. Automated Enrichment, Transduction, and Expansion of Clinical-Scale CD62L+ T Cells for Manufacturing of Gene Therapy Medicinal Products

    PubMed Central

    Priesner, Christoph; Aleksandrova, Krasimira; Esser, Ruth; Mockel-Tenbrinck, Nadine; Leise, Jana; Drechsel, Katharina; Marburger, Michael; Quaiser, Andrea; Goudeva, Lilia; Arseniev, Lubomir; Kaiser, Andrew D.; Glienke, Wolfgang; Koehl, Ulrike

    2016-01-01

    Multiple clinical studies have demonstrated that adaptive immunotherapy using redirected T cells against advanced cancer has led to promising results with improved patient survival. The continuously increasing interest in those advanced gene therapy medicinal products (GTMPs) leads to a manufacturing challenge regarding automation, process robustness, and cell storage. Therefore, this study addresses the proof of principle in clinical-scale selection, stimulation, transduction, and expansion of T cells using the automated closed CliniMACS® Prodigy system. Naïve and central memory T cells from apheresis products were first immunomagnetically enriched using anti-CD62L magnetic beads and further processed freshly (n = 3) or split for cryopreservation and processed after thawing (n = 1). Starting with 0.5 × 108 purified CD3+ T cells, three mock runs and one run including transduction with green fluorescent protein (GFP)-containing vector resulted in a median final cell product of 16 × 108 T cells (32-fold expansion) up to harvesting after 2 weeks. Expression of CD62L was downregulated on T cells after thawing, which led to the decision to purify CD62L+CD3+ T cells freshly with cryopreservation thereafter. Most important in the split product, a very similar expansion curve was reached comparing the overall freshly CD62L selected cells with those after thawing, which could be demonstrated in the T cell subpopulations as well by showing a nearly identical conversion of the CD4/CD8 ratio. In the GFP run, the transduction efficacy was 83%. In-process control also demonstrated sufficient glucose levels during automated feeding and medium removal. The robustness of the process and the constant quality of the final product in a closed and automated system give rise to improve harmonized manufacturing protocols for engineered T cells in future gene therapy studies. PMID:27562135

  12. The Archveyor{trademark} mining system: Automated high wall mining, a precursor to improved safety, productivity, and cost underground

    SciTech Connect

    Sawarynski, T.J.

    1996-12-31

    Arch Mineral Corporation has an automated high wall miner called the Archveyor {trademark}. In production since 1992, it uses just two employees to operate the system. They consistently produce 91 metric tons per eight-hour employer-shift with peaks nearing 226 metric tons. The system uses a modified Joy 12CM miner cutting 3.7 meters. That loads into a 219 meter long continuous haulage Archveyor{trademark}. It discharges into a loadout vehicle that elevates the coal to load haul trucks. This technology can be adapted to mine over 305 meters into the high wall. Any continuous miner can be used to suit conditions. It is programmed to sump, shear down, sump, and shear up in a continuous cycle. It advances a set distance before the Archveyor{trademark} moves up behind it. The Archveyor{trademark} has a flight conveyor 838 mm wide used to tram and convey. Lift cylinders raise it off the ground to convey. To tram, the cylinders retract, dropping the Archveyor{trademark} to the ground. That places the full length of the return side or bottom of the flight conveyor in contract with the floor to tram in either direction. Programmable logic controllers are used with a gyroscope, gamma detectors, and inclinometers to keep on-heading and in-seam. Critical system functions are monitored and displayed for the operator. Safety, lower costs, and higher productivity drive the effort to use the Archveyor{trademark} technology underground. Arch Technology is assembling and preparing to install an underground system in the third quarter of 1996.

  13. High-end aerial digital cameras and their impact on the automation and quality of the production workflow

    NASA Astrophysics Data System (ADS)

    Paparoditis, Nicolas; Souchon, Jean-Philippe; Martinoty, Gilles; Pierrot-Deseilligny, Marc

    The IGN digital camera project was established in the early 1990s. The first research surveys were carried out in 1996 and the digital camera was first used in production in 2000. In 2004 approximately 10 French departments (accounting for 10% of the territory) were covered with a four-head camera system and since summer 2005 all IGN imagery has been acquired digitally. Nevertheless the camera system is still evolving, with tests on new geometric configurations being continuously undertaken. The progressive integration of the system in IGN production workflows has allowed IGN to keep the system evolving in accordance with production needs. Remaining problems are due to specific camera characteristics such as CCD format, the optical quality of off-the-shelf lenses, and because some production tools are ill-adapted to digital images with a large dynamic range. However, when considering the pros and cons of integrating these images into production lines, the disadvantages are largely balanced by the numerous benefits this technology offers.

  14. Control of automated behavior: insights from the discrete sequence production task

    PubMed Central

    Abrahamse, Elger L.; Ruitenberg, Marit F. L.; de Kleine, Elian; Verwey, Willem B.

    2013-01-01

    Work with the discrete sequence production (DSP) task has provided a substantial literature on discrete sequencing skill over the last decades. The purpose of the current article is to provide a comprehensive overview of this literature and of the theoretical progress that it has prompted. We start with a description of the DSP task and the phenomena that are typically observed with it. Then we propose a cognitive model, the dual processor model (DPM), which explains performance of (skilled) discrete key-press sequences. Key features of this model are the distinction between a cognitive processor and a motor system (i.e., motor buffer and motor processor), the interplay between these two processing systems, and the possibility to execute familiar sequences in two different execution modes. We further discuss how this model relates to several related sequence skill research paradigms and models, and we outline outstanding questions for future research throughout the paper. We conclude by sketching a tentative neural implementation of the DPM. PMID:23515430

  15. A semi-automated process for the production of custom-made shoes

    NASA Technical Reports Server (NTRS)

    Farmer, Franklin H.

    1991-01-01

    A more efficient, cost-effective and timely way of designing and manufacturing custom footware is needed. A potential solution to this problem lies in the use of computer-aided design and manufacturing (CAD/CAM) techniques in the production of custom shoes. A prototype computer-based system was developed, and the system is primarily a software entity which directs and controls a 3-D scanner, a lathe or milling machine, and a pattern-cutting machine to produce the shoe last and the components to be assembled into a shoe. The steps in this process are: (1) scan the surface of the foot to obtain a 3-D image; (2) thin the foot surface data and create a tiled wire model of the foot; (3) interactively modify the wire model of the foot to produce a model of the shoe last; (4) machine the last; (5) scan the surface of the last and verify that it correctly represents the last model; (6) design cutting patterns for shoe uppers; (7) cut uppers; (8) machine an inverse mold for the shoe innersole/sole combination; (9) mold the innersole/sole; and (10) assemble the shoe. For all its capabilities, this system still requires the direction and assistance of skilled operators, and shoemakers to assemble the shoes. Currently, the system is running on a SUN3/260 workstation with TAAC application accelerator. The software elements of the system are written in either Fortran or C and run under a UNIX operator system.

  16. [Scientific productivity standards and the National Automous University of Mexico School of Medicine].

    PubMed

    Martínez, Federico; Palomares, Alejandra; Piña, Enrique

    2004-01-01

    The scientific production at theNational Autonomous University of Mexico (Universidad Nacional Autónoma de México, UNAM) School of Medicine was analyzed during the period from 1999 to 2002. We found the following: 1) 94.83% of total international scientific papers was recovered; 2) mean impact factor had a value of 2.5, ca. the value reported by CONACYT, México, for the period 1998-2002; 3) percentage of corresponding authors was 58.83%, 27.80% of papers were national collaborations, 9.83% were international collaborations, and 3.37% corresponded to personal publications; 4) by using corresponding author and collaborations, academic leaders were identified; 5) there are differences among academic departments, and 6) basic research from the UNAM School of Medicine contributes 14% of national research and teaches ca. 2,450 students per year. It is proposed that this type of analysis should be used to establish the politics of science.

  17. A semi-automated process for the production of custom-made shoes

    NASA Astrophysics Data System (ADS)

    Farmer, Franklin H.

    1991-03-01

    A more efficient, cost-effective and timely way of designing and manufacturing custom footware is needed. A potential solution to this problem lies in the use of computer-aided design and manufacturing (CAD/CAM) techniques in the production of custom shoes. A prototype computer-based system was developed, and the system is primarily a software entity which directs and controls a 3-D scanner, a lathe or milling machine, and a pattern-cutting machine to produce the shoe last and the components to be assembled into a shoe. The steps in this process are: (1) scan the surface of the foot to obtain a 3-D image; (2) thin the foot surface data and create a tiled wire model of the foot; (3) interactively modify the wire model of the foot to produce a model of the shoe last; (4) machine the last; (5) scan the surface of the last and verify that it correctly represents the last model; (6) design cutting patterns for shoe uppers; (7) cut uppers; (8) machine an inverse mold for the shoe innersole/sole combination; (9) mold the innersole/sole; and (10) assemble the shoe. For all its capabilities, this system still requires the direction and assistance of skilled operators, and shoemakers to assemble the shoes. Currently, the system is running on a SUN3/260 workstation with TAAC application accelerator. The software elements of the system are written in either Fortran or C and run under a UNIX operator system.

  18. Molecular breeding of tomato lines for mass production of miraculin in a plant factory.

    PubMed

    Kato, Kazuhisa; Yoshida, Riichiro; Kikuzaki, Ayako; Hirai, Tadayoshi; Kuroda, Hirofumi; Hiwasa-Tanase, Kyoko; Takane, Kenichi; Ezura, Hiroshi; Mizoguchi, Tsuyoshi

    2010-09-08

    A transgenic tomato line (56B, "Moneymaker") that expresses the miraculin gene driven by the CaMV 35S promoter was crossed with a dwarf tomato ("Micro-Tom") for the molecular breeding of cultivars that are suitable for miraculin production in a closed cultivation system. Plant size, miraculin accumulation, and self-pruning growth were used as selection indicators for F2 plants. Two lines were chosen for further analysis, bred to the F6 or F7 generation and cultivated in a closed cultivation system. In 56B and the two crossed lines, the concentrations of miraculin in the pericarp were 140, 367, and 343 microg/g FW, respectively. We also estimated that 26.2, 73.6, and 45.9 kg FW/m2 of tomatoes and 2.2, 16.6, and 9.8 mg/m2 of miraculin in the pericarp, respectively, could be harvested per year. These two crossed lines will be useful for the mass production of miraculin, especially in a closed cultivation system.

  19. X-ray and gamma-ray line production by nonthermal ions

    NASA Technical Reports Server (NTRS)

    Bussard, R. W.; Omidvar, K.; Ramaty, R.

    1977-01-01

    X-ray production was calculated at approximately 6.8 keV by the 2p to 1s transition in fast hydrogen- and helium-like iron ions, following both electron capture to excited levels and collisional excitation. A refinement of the OBK approximation was used to obtain an improved charge exchange cross section. This, and the corresponding ionization cross section were used to determine equilibrium charge fractions for iron ions as functions of their energy. The effective X-ray line production cross section was found to be sharply peaked in energy at about 8 to 12 MeV/amu. Because fast ions of similar energies can also excite nuclear levels, the ratio of selected strong gamma ray line emissivities to the X-ray line emissivity was also calculated. Limits set by this method on the intensity of gamma ray line emission from the galactic center and the radio galaxy Centaurus A are generally lower than those reported in the literature.

  20. X-ray and gamma-ray line production by nonthermal ions. [in interstellar medium

    NASA Technical Reports Server (NTRS)

    Bussard, R. W.; Ramaty, R.; Omidvar, K.

    1978-01-01

    X-ray production at about 6.8 keV by the 2p to 1s transition in fast hydrogen- and helium-like iron ions is calculated, following both electron capture to excited levels and collisional excitation. A refinement of the Oppenheimer-Brinkman-Kramers (1930) approximation is used to obtain an improved charge-exchange cross-section. This, and the corresponding ionization cross section, were used to determine equilibrium charge fractions for iron ions as functions of their energy. The effective X-ray line production cross section was found to be sharply peaked in energy at about 8 to 12 MeV per amu. Since fast ions of similar energies can also excite nuclear levels, the ratio of selected strong gamma-rays line emissivities to the X-ray line emissivity is calculated. These calculations are employed to set limits on the intensity of gamma-rays line emission from the galactic center and the radio galaxy Cen A, and it is found that these limits are generally lower than those reported in the literature.