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Sample records for avada eli vaatlejate

  1. Anidulafungin (Eli Lilly & Co).

    PubMed

    Hawser, S

    1999-12-01

    The pentyloxyterphenyl side chain derivative of echinocandin B, anidulafungin, is a 1,3-alpha-glucan synthesis inhibitor undergoing phase II clinical trials by Versicor and Eli Lilly, in various formulations, for the potential treatment of fungal and protozoal infections. Eli Lilly has retained options to the oral formulation of the compound, but development, clinical registration and marketing rights were licensed to Versicor in June 1999. The primary target of this compound is Candida, but Eli Lilly also intends to develop the drug for Aspergillus infections. No activity has been shown against Cryptococcus. The oral activity of anidulafungin is compromised by a low bioavailability, a decreased absorption when taken with food, and gastrointestinal side effects at higher doses. The development of a phosphorylated prodrug, LY-307853, which is converted in the body to anidulafungin by tissue and serum phosphatases, was discontinued in favor of an oral formulation, which uses anidulafungin directly. In February 1999, Deutsche Bank predicted sales of $100 million in 2001, rising to $300 million in 2003.

  2. Drotrecogin alfa Eli Lilly.

    PubMed

    de Jonge, E

    2002-04-01

    Drotrecogin alfa (Xigris, recombinant activated protein C) is an anticoagulant developed and launched by Eli Lilly & Co for the treatment of sepsis [333781], [339372], [430133], [436271]. The FDA and the EMEA accepted the brand name Xigris for drotrecogin alfa in June 2001. This trade name had been proposed by Lilly in place of the previous brand name, Zovant, which was deemed unacceptable by the EMEA due to concerns that the name could be confused with hospital-based drugs [412512]. Filings for sepsis were made in the US, EU and Australia in February 2001 [398514], [447870] and in March 2001, the US FDA assigned drotrecogin alfa Priority Review status [403435]. The FDA extended the action date from July 27 to October 27, 2001 for completion of its review of the biologics license application (BLA) for drotrecogin alfa to assess further supplementary data submitted by Lilly [412512]. At the October 16, 2001 meeting (postponed from September 12), the FDA Advisory Committee on Anti-Infective Drugs split 10 to 10 over whether to recommend approval [425873], [425940]. In late October 2001, Lilly received an approvable letter from the FDA for the treatment of severe sepsis. Approval was contingent upon successful negotiation of labeling, agreement on post-approval clinical trials, and successful completion of manufacturing inspections [427301]. In November 2001, the FDA approved drotrecogin alfa for the reduction of mortality in adult patients with severe sepsis who have a high risk of death [430133]; the product was launched onto the US market days later [436271]. Following the FDA committee's split decision in October 2001, Credit Suisse First Boston, which expected mid-2002 approval but with restrictive labeling, revised its predictions from $1.265 billion in 2004 sharply downwards to $543 million [425929].

  3. "ELI"--The Educational Futures Game.

    ERIC Educational Resources Information Center

    Mahoney, V. L. Mike; Grantham, Lex

    This report describes ELI, a computer-based educational game that gives participants, as citizens of fictitious cities, the opportunity to examine a variety of typical community issues relating to education within the context of broader city and regional problems. After a brief introduction, the game structure is described, including the setting…

  4. Gamma beam system at ELI-NP

    SciTech Connect

    Ur, Calin Alexandru

    2015-02-24

    The Gamma Beam System of ELI-NP will produce brilliant, quasi-monochromatic gamma-ray beams via Inverse Compton Scattering of short laser pulses on relativistic electron beam pulses. The scattered radiation is Doppler upshifted by more than 1,000,000 times and is forward focused in a narrow, polarized, tunable, laser-like beam. The gamma-ray beam at ELI-NP will be characterized by large spectral density of about 10{sup 4} photons/s/eV, narrow bandwidth (< 0.5%) and tunable energy from 200 keV up to about 20 MeV. The Gamma Beam System is a state-of-the-art equipment employing techniques and technologies at the limits of the present-day's knowledge.

  5. 78 FR 49723 - Humboldt-Toiyabe National Forests; Ely Ranger District; Ely Westside Rangeland Project

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-15

    ... National Forest System (NFS) lands within the boundaries administered by the Ely Ranger District. The... Statement and Record of Decision were distributed in September 2011. While considering an appeal on the... additional information on the development of stocking rates on the allotments in the project area. DATES:...

  6. Elie Metchnikoff, the Man and the Myth.

    PubMed

    Gordon, Siamon

    2016-01-01

    The year 2016 marks the centenary of the death of Elie Metchnikoff, the father of innate immunity and discoverer of the significance of phagocytosis in development, homeostasis and disease. Through a series of intravital experiments on invertebrates and vertebrates, he described the role of specialised phagocytic cells, macrophages and microphages, subsequently renamed neutrophils and polymorphonuclear leucocytes, in the host response to injury, inflammation, infection and tissue repair. As a vigorous proponent of cellular immunity, he championed its importance versus humoral immunity in the so-called antibody wars. By 1908, when the Nobel Prize was awarded to Elie Metchnikoff and Paul Ehrlich, this debate was not yet resolved. Even earlier, Metchnikoff had turned his research interests to the process of ageing and the possible link to intestinal auto-intoxication, giving rise to the current interest in the microbiome of the gut and the use of probiotics to promote health and longevity. During the past century, Metchnikoff's reputation has waxed and waned, as lymphocyte heterogeneity, specificity and memory began to dominate the field of adaptive immunity, yet his benign visage continues to provide an iconic presence for specialists in innate immunology, whose studies have made a striking comeback in the past decade. In this review, I shall consider the nature of his studies and the person as well as the legendary description of his Eureka experience in Messina in 1882, a story loved by students and investigators alike, that marked, in his own words, his transformation from zoologist to pathologist.

  7. 76 FR 53898 - Proposed Administrative Settlement Agreement and Order on Consent; In Re: Ely Copper Mine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-30

    ... AGENCY Proposed Administrative Settlement Agreement and Order on Consent; In Re: Ely Copper Mine... concerning the Ely Copper Mine Superfund Site in Vershire, Vermont with the following settling party: Ely... e-mail at gardner.ann@epa.gov . Additional information on the Ely Copper Mine Superfund Site can...

  8. 3. Historic American Buildings Survey Eli Lilly Company Photographic Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey Eli Lilly Company Photographic Department - About 1937-1938 Gift courtesy of Edward D. James, FAIA, Preservation Officer RESTORED INTERIOR - CORNER OF BUILDING - William Conner Trading Post, State Highway 234, Noblesville, Hamilton County, IN

  9. Radiation protection of a proton beamline at ELI-Beamlines

    NASA Astrophysics Data System (ADS)

    Bechet, S.; Versaci, R.; Rollet, S.; Olsovcova, V.; Fajstavr, A.; Zakova, M.; Margarone, D.

    2016-12-01

    ELI-Beamlines (ELI stands for Extreme Light Infrastructure) is a new EU funded laser facility located near Prague, in Czech Republic. It will use laser-driven plasma sources to accelerate particles and host a dedicated proton beamline called ELIMAIA (ELI Multidisciplinary Applications of laser- Ion Acceleration) designed to reach energies up to 250 MeV. This beamline could be exploited to study possible future medical application of laser-driven beams. The first part of this paper introduces the beamline, the corresponding source terms and the complete set-up. The second part of the paper details the evaluation of the ambient dose equivalent and the activation study inside the experimental halls based on Monte-Carlo simulation. These calculations show that the ELIMAIA operation is safe as long as nobody is present in the hall when the beam is on.

  10. Gamma beam industrial applications at ELI-NP

    NASA Astrophysics Data System (ADS)

    Suliman, Gabriel; Iancu, Violeta; Ur, Calin A.; Iovea, Mihai; Daito, Izuru; Ohgaki, Hideaki

    2016-09-01

    The Nuclear Physics oriented pillar of the pan-European Extreme Light Infrastructure (ELI-NP) will host an ultra-bright, energy tunable, and quasi-monochromatic gamma-ray beam system in the range of 0.2-19.5 MeV produced by laser Compton backscattering. This gamma beam satisfies the criteria for large-size product investigations with added capabilities like isotope detection through the use of nuclear resonance fluorescence (NRF) and is ideal for non-destructive testing applications. Two major applications of gamma beams are being envisaged at ELI-NP: industrial applications based on NRF and industrial radiography and tomography. Both applications exploit the unique characteristics of the gamma beam to deliver new opportunities for the industry. Here, we present the experimental setups proposed at ELI-NP and discuss their performance based on analytical calculations and GEANT4 numerical simulations. One of the main advantages of using the gamma beam at ELI-NP for applications based on NRF is the availability of an advanced detector array, which can enhance the advantages already provided by the high quality of the gamma beam.

  11. 1. Historic American Buildings Survey Eli Lilly Company Photographic Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Eli Lilly Company Photographic Department - About 1937-1938 Gift courtesy of Edward D. James, FAIA, Preservation Officer GENERAL VIEW OF TRADING POST (LEFT) AND CABIN OF WILLIAM CONNER (RIGHT) AFTER RESTORATION - William Conner Trading Post, State Highway 234, Noblesville, Hamilton County, IN

  12. 2. Historic American Buildings Survey Eli Lilly Company Photographic Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey Eli Lilly Company Photographic Department - About 1937-1938 Gift courtesy of Edward D. James, FAIA, Preservation Officer RESTORED INTERIOR SHOWING STORE SHELVING AND COUNTER - William Conner Trading Post, State Highway 234, Noblesville, Hamilton County, IN

  13. Assessing Eli Broad's Assault on Public School System Leadership

    ERIC Educational Resources Information Center

    English, Fenwick W.; Crowder, Zan

    2012-01-01

    Eli Broad's approach to reforming urban public education does not recognize his own self-interest in promoting changes within such educational systems, a classic problem of misrecognition. The Broad agenda is an assault on the notion of the mission of public education as a service instead of a for-profit enterprise concerned with making money for…

  14. Extreme Light Infrastructure - Nuclear Physics Eli-Np Project

    NASA Astrophysics Data System (ADS)

    Gales, S.

    2015-06-01

    The development of high power lasers and the combination of such novel devices with accelerator technology has enlarged the science reach of many research fields, in particular High energy, Nuclear and Astrophysics as well as societal applications in Material Science, Nuclear Energy and Medicine. The European Strategic Forum for Research Infrastructures (ESFRI) has selected a proposal based on these new premises called "ELI" for Extreme Light Infrastructure. ELI will be built as a network of three complementary pillars at the frontier of laser technologies. The ELI-NP pillar (NP for Nuclear Physics) is under construction near Bucharest (Romania) and will develop a scientific program using two 10 PW class lasers and a Back Compton Scattering High Brilliance and Intense Low Energy Gamma Beam , a marriage of Laser and Accelerator technology at the frontier of knowledge. In the present paper, the technical description of the facility, the present status of the project as well as the science, applications and future perspectives will be discussed.

  15. Perspectives for photonuclear research at the Extreme Light Infrastructure - Nuclear Physics (ELI-NP) facility

    NASA Astrophysics Data System (ADS)

    Filipescu, D.; Anzalone, A.; Balabanski, D. L.; Belyshev, S. S.; Camera, F.; La Cognata, M.; Constantin, P.; Csige, L.; Cuong, P. V.; Cwiok, M.; Derya, V.; Dominik, W.; Gai, M.; Gales, S.; Gheorghe, I.; Ishkhanov, B. S.; Krasznahorkay, A.; Kuznetsov, A. A.; Mazzocchi, C.; Orlin, V. N.; Pietralla, N.; Sin, M.; Spitaleri, C.; Stopani, K. A.; Tesileanu, O.; Ur, C. A.; Ursu, I.; Utsunomiya, H.; Varlamov, V. V.; Weller, H. R.; Zamfir, N. V.; Zilges, A.

    2015-12-01

    The perspectives for photonuclear experiments at the new Extreme Light Infrastructure - Nuclear Physics (ELI-NP) facility are discussed in view of the need to accumulate novel and more precise nuclear data. The parameters of the ELI-NP gamma beam system are presented. The emerging experimental program, which will be realized at ELI-NP, is presented. Examples of day-one experiments with the nuclear resonance fluorescence technique, photonuclear reaction measurements, photofission experiments and studies of nuclear collective excitation modes and competition between various decay channels are discussed. The advantages which ELI-NP provides for all these experiments compared to the existing facilities are discussed.

  16. Simulation of photofission experiments at the ELI-NP facility

    NASA Astrophysics Data System (ADS)

    Constantin, P.; Balabanski, D. L.; Cuong, P. V.

    2016-04-01

    An extensive experimental program for the study of photofission will take place at the Extreme Light Infrastructure - Nuclear Physics (ELI-NP) facility, where different actinide targets will be exposed to a brilliant gamma beam to produce fission fragments. We report on the implementation within the Geant4 simulation toolkit of the photofission process, of related background processes, and of extended ionic charge parameterization. These developments are used to evaluate the production rates of photofission fragments and their release efficiency from the actinide targets.

  17. 1. Historic American Buildings Survey Eli Lilly Company Photographic Department ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey Eli Lilly Company Photographic Department - About 1937-1938 Gift courtesy of Edward D. James, FAIA, Preservation Officer SKETCH PLAN OF FARM Legend: (1) William Conner House; (2) Still house; (3) Milk house; (4) Museum; (5) Loom house; (6) Modern barns, grain and implement storage; (7) Three-eighths of a mile north or here on the river bank, William Conner lived in a double cabin trading post; (8) Trading post; (9) Conner cabin; (10) Pioneer barn - William Conner Prairie Farm, State Highway 234, Noblesville, Hamilton County, IN

  18. The ELI-NP facility for nuclear physics

    NASA Astrophysics Data System (ADS)

    Ur, C. A.; Balabanski, D.; Cata-Danil, G.; Gales, S.; Morjan, I.; Tesileanu, O.; Ursescu, D.; Ursu, I.; Zamfir, N. V.

    2015-07-01

    Extreme Light Infrastructure-Nuclear Physics (ELI-NP) is aiming to use extreme electromagnetic fields for nuclear physics research. The facility, currently under construction at Magurele-Bucharest, will comprise a high power laser system and a very brilliant gamma beam system. The technology involved in the construction of both systems is at the limits of the present-day's technological capabilities. The high power laser system will consist of two 10 PW lasers and it will produce intensities of up to 1023-1024 W/cm2. The gamma beam, produced via Compton backscattering of a laser beam on a relativistic electron beam, will be characterized by a narrow bandwidth (<0.5%) and tunable energy of up to almost 20 MeV. The research program of the facility covers a broad range of key topics in frontier fundamental physics and new nuclear physics. A particular attention is given to the development of innovative applications. In the present paper an overview of the project status and the overall performance characteristics of the main research equipment will be given. The main fundamental physics and applied research topics proposed to be studied at ELI-NP will also be briefly reviewed.

  19. A new-concept gamma calorimeter at ELI-NP

    NASA Astrophysics Data System (ADS)

    Lenzi, M.; Adriani, O.; Albergo, S.; Andreotti, M.; Berto, D.; Borgheresi, R.; Cappello, G.; Cardarelli, P.; Ciaranfi, R.; Consoli, E.; Di Domenico, G.; Evangelisti, F.; Gambaccini, M.; Graziani, G.; Marziani, M.; Palumbo, L.; Passaleva, G.; Pellegriti, M. G.; Serban, A.; Starodubtsev, O.; Statera, M.; Tricomi, A.; Variola, A.; Veltri, M.

    2017-02-01

    ELI-NP is an European Research Infrastructure that will provide a monochromatic, high brilliance gamma beam with tunable energy up to 19.5 MeV. The time structure of the beam consists of 32 high intensity gamma bunches separated by a time interval of 16 ns and delivered at a repetition rate of 100 Hz. In order to match such unprecedented beam specifications, specific devices and techniques have been developed to measure and monitor the beam parameters during the commissioning and the operational phase. This paper presents an overview of the gamma beam characterization system, with particular focus on a new-concept sampling calorimeter made of silicon detectors and polyethylene absorbers.

  20. ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and replication licensing.

    PubMed

    Gillespie, Peter J; Khoudoli, Guennadi A; Stewart, Graeme; Swedlow, Jason R; Blow, J Julian

    2007-10-09

    Xenopus egg extract supports all the major cell-cycle transitions in vitro. We have used a proteomics approach to identify proteins whose abundance on chromatin changes during the course of an in vitro cell cycle. One of the proteins we identified was ELYS/MEL-28, which has recently been described as the earliest-acting factor known to be required for nuclear pore complex (NPC) assembly [1-4]. ELYS interacts with the Nup107-160 complex and is required for its association with chromatin. ELYS contains an AT-hook domain, which we show binds to chromatin with a high affinity. This domain can compete with full-length ELYS for chromatin association, thereby blocking NPC assembly. This provides evidence that ELYS interacts directly with chromatin and that this interaction is essential for NPC assembly and compartmentalization of chromosomal DNA within the cell. Furthermore, we detected a physical association on chromatin between ELYS and the Mcm2-7 replication-licensing proteins. ELYS chromatin loading, NPC assembly, and nuclear growth were delayed when Mcm2-7 was prevented from loading onto chromatin. Because nuclear assembly is required to shut down licensing prior to entry into S phase, our results suggest a mechanism by which these two early cell-cycle events are coordinated with one another.

  1. Latest results of 10 petawatt laser beamline for ELi nuclear physics infrastructure

    NASA Astrophysics Data System (ADS)

    Lureau, F.; Laux, S.; Casagrande, O.; Chalus, O.; Pellegrina, A.; Matras, G.; Radier, C.; Rey, G.; Ricaud, S.; Herriot, S.; Jougla, P.; Charbonneau, M.; Duvochelle, P. A.; Simon-Boisson, C.

    2016-03-01

    A laser system made of two beams of 10 PW each has been designed and is currently built for ELI-NP research infrastructure. Design is presented as well as preliminary results up to the 1PW level amplifier.

  2. Chaos in the Showalter-Noyes-Bar-Eli model of the Belousov-Zhabotinskii reaction

    NASA Astrophysics Data System (ADS)

    Lindberg, David; Turner, Jack S.; Barkley, Dwight

    1990-03-01

    The observation of robust, large-scale chaos in the Showalter-Noyes-Bar-Eli model of the Belousov-Zhabotinskii reaction is reported. The chaos observed is comparable to that found in CSTR experiments at low flow rates.

  3. Straight talk with... Ricardo Dolmetsch. Interview by Elie Dolgin.

    PubMed

    Dolmetsch, Ricardo

    2013-11-01

    Neuroscience, in recent years, has started to look like a graveyard for drug development, with many large pharmaceutical companies either eliminating their brain disorder programs or cutting back heavily on such research. Novartis seemed to have made exactly this kind of drastic change two years ago when the company announced plans to shutter its neuroscience operations at its global headquarters in Basel, Switzerland. But the company made it known then that its intention was to ultimately set up a new neuroscience division at the company's US base in Cambridge, Massachusetts. The US site was initially picked to take advantage of the local academic strength in the field of psychiatric genetics. Now, it seems that Novartis is also looking to add stem cell technologies to the mix with the appointment in August of Ricardo Dolmetsch as the company's global head of neurosciences-the first new hire for the company's reincarnated division. As a professor at California's Stanford University School of Medicine for the past ten years, Dolmetsch made his name using induced pluripotent stem (iPS) cells to study a rare form of autism known as Timothy syndrome. Elie Dolgin met with Dolmetsch at the Novartis Institutes for BioMedical Research in the Technology Square area of Cambridge to discuss how he plans to succeed where so many others have failed.

  4. Eli Lilly and Company's bioethics framework for human biomedical research.

    PubMed

    Van Campen, Luann E; Therasse, Donald G; Klopfenstein, Mitchell; Levine, Robert J

    2015-11-01

    Current ethics and good clinical practice guidelines address various aspects of pharmaceutical research and development, but do not comprehensively address the bioethical responsibilities of sponsors. To fill this void, in 2010 Eli Lilly and Company developed and implemented a Bioethics Framework for Human Biomedical Research to guide ethical decisions. (See our companion article that describes how the framework was developed and implemented and provides a critique of its usefulness and limitations.) This paper presents the actual framework that serves as a company resource for employee education and bioethics deliberations. The framework consists of four basic ethical principles and 13 essential elements for ethical human biomedical research and resides within the context of our company's mission, vision and values. For each component of the framework, we provide a high-level overview followed by a detailed description with cross-references to relevant well regarded guidance documents. The principles and guidance described should be familiar to those acquainted with research ethics. Therefore the novelty of the framework lies not in the foundational concepts presented as much as the attempt to specify and compile a sponsor's bioethical responsibilities to multiple stakeholders into one resource. When such a framework is employed, it can serve as a bioethical foundation to inform decisions and actions throughout clinical planning, trial design, study implementation and closeout, as well as to inform company positions on bioethical issues. The framework is, therefore, a useful tool for translating ethical aspirations into action - to help ensure pharmaceutical human biomedical research is conducted in a manner that aligns with consensus ethics principles, as well as a sponsor's core values.

  5. Implementation status of the extreme light infrastructure - nuclear physics (ELI-NP) project

    NASA Astrophysics Data System (ADS)

    Gales, S.; Zamfir, N. V.

    2015-02-01

    The Project Extreme Light Infrastructure (ELI) is part of the European Strategic Forum for Research Infrastructures (ESFRI) Roadmap. ELI will be built as a network of three complementary pillars at the frontier of laser technologies. The ELI-NP pillar (NP for Nuclear Physics) is under construction near Bucharest (Romania) and will develop a scientific program using two 10 PW lasers and a Compton back-scattering high-brilliance and intense gamma beam, a marriage of laser and accelerator technology at the frontier of knowledge. In the present paper, the technical description of the facility, the present status of the project as well as the science, applications and future perspectives will be discussed.

  6. Implementation status of the extreme light infrastructure - nuclear physics (ELI-NP) project

    SciTech Connect

    Gales, S. Zamfir, N. V.

    2015-02-24

    The Project Extreme Light Infrastructure (ELI) is part of the European Strategic Forum for Research Infrastructures (ESFRI) Roadmap. ELI will be built as a network of three complementary pillars at the frontier of laser technologies. The ELI-NP pillar (NP for Nuclear Physics) is under construction near Bucharest (Romania) and will develop a scientific program using two 10 PW lasers and a Compton back-scattering high-brilliance and intense gamma beam, a marriage of laser and accelerator technology at the frontier of knowledge. In the present paper, the technical description of the facility, the present status of the project as well as the science, applications and future perspectives will be discussed.

  7. Extreme Light Infrastructure Nuclear Physics (ELI-NP): Present status and perspectives

    NASA Astrophysics Data System (ADS)

    Zamfir, N. V.

    2016-05-01

    Extreme Light Infrastructure - Nuclear Physics (ELI-NP), a new Research Center under construction, will use extreme electromagnetic fields for nuclear physics research and will be operational in 2018. The status of the Project implementation will be presented. At ELI-NP, a high power laser system together with a very brilliant gamma beam are the two main research tools. Their targeted operational parameters will be described. The related experimental set-ups will be presented, together with the main directions of the research envisioned.

  8. Future prospects of nuclear reactions induced by gamma-ray beams at ELI-NP

    NASA Astrophysics Data System (ADS)

    Filipescu, D.; Balabanski, D. L.; Camera, F.; Gheorghe, I.; Ghita, D.; Glodariu, T.; Kaur, J.; Ur, C. A.; Utsunomiya, H.; Varlamov, V. V.

    2017-01-01

    The future prospects of photonuclear reactions studies at the new Extreme Light Infrastructure—Nuclear Physics (ELI-NP) facility are discussed in view of the pursuit of investigating the electromagnetic response of nuclei using γ-ray beams of unprecedented energy resolution and intensity characteristics. We present here the features of the γ-ray beam source, the emerging ELI-NP experimental program involving photonuclear reactions cross section measurements and spectroscopy and angular measurements of γ-rays and neutrons along with the detection arrays currently under implementation.

  9. Aquatic assessment of the Ely Copper Mine Superfund site, Vershire, Vermont

    USGS Publications Warehouse

    Seal, Robert R., II; Kiah, Richard G.; Piatak, Nadine M.; Besser, John M.; Coles, James F.; Hammarstrom, Jane M.; Argue, Denise M.; Levitan, Denise M.; Deacon, Jeffrey R.; Ingersoll, Christopher G.

    2010-01-01

    The information was used to develop an overall assessment of the impact on the aquatic system that appears to be a result of the acid rock drainage at the Ely Mine. More than 700 meters of Ely Brook, including two of the six ponds, were found to be severely impacted, on the basis of water-quality data and biological assessments. The reference location was of good quality based on the water quality and biological assessment. More than 3,125 meters of Schoolhouse Brook are also severely impacted, on the basis of water-quality data and biological assessments. The biological community begins to recover near the confluence with the Ompompanoosuc River. The evidence is less conclusive regarding the Ompompanoosuc River. The sediment data suggest that the sediments could be a source of toxicity in Ely Brook and Schoolhouse Brook. The surface-water assessment is consistent with the outcome of a surface-water toxicity testing program performed by the U.S. Environmental Protection Agency for Ely Brook and Schoolhouse Brook and a surface-water toxicity testing program and in situ amphibian testing program for the ponds.

  10. 78 FR 21849 - Television Broadcasting Services; Ely, NV to Middletown Township, NJ

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... From the Federal Register Online via the Government Publishing Office FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 73 Television Broadcasting Services; Ely, NV to Middletown Township, NJ AGENCY... U.S.C. 801(a)(1)(A). List of Subjects in 47 CFR Part 73 Television. Federal...

  11. Clinical utility of the Duncan-Ely test for rectus femoris dysfunction during the swing phase of gait.

    PubMed

    Marks, M C; Alexander, J; Sutherland, D H; Chambers, H G

    2003-11-01

    The Ely Test (or Duncan-Ely test) has been accepted as a clinical tool to assess rectus femoris spasticity by passively flexing the knee rapidly while the patient lies prone in a relaxed state. In this retrospective review, patients' dynamic knee range of motion (ROM) during gait and an electromyogram (EMG) were compared with the results of the Ely test. Data for 70 patients (44 males, 26 females; 104 limbs) were included. Mean age of patients was 13 years, SD 9 years, range 4 years 5 months to 54 years. All patients were diagnosed with cerebral palsy (spastic diplegia, n = 42; spastic quadriplegia, n = 15, and hemiplegia, n = 13). All patients were ambulatory (50 independent, 20 with assistive devices). A standard matrix was used to calculate sensitivity and specificity of the Ely test as well as its positive and negative predictive value. For the gait variables examined (decreased dynamic knee ROM, timing of peak knee flexion, and abnormal EMG in swing) the sensitivity of the Ely test ranged from 56 to 59% and the specificity ranged from 64 to 85%. For the same variables the positive predictive value ranged from 91 to 98% and the negative predictive value ranged from 4 to 19%. The Ely test was shown to have a good positive predictive value (i.e. the certainty about the presence of rectus spasticity in patients with a positive Ely test result) for rectus femoris dysfunction during gait.

  12. Notch effects on high-cycle fatigue properties of Ti 6Al 4V ELI alloy at cryogenic temperatures

    NASA Astrophysics Data System (ADS)

    Yuri, T.; Ono, Y.; Ogata, T.

    2006-01-01

    Notch effects on the high-cycle fatigue properties of the forged Ti-6Al-4V ELI alloy at cryogenic temperatures were investigated. Also, the high-cycle fatigue data were compared with the rolled Ti-5Al-2.5Sn ELI alloy. The one million cycles fatigue strength (FS) of the smooth specimen for the forged Ti-6Al-4V ELI alloy increased with a decrease of test temperature. However, the FS of each notched specimen at 4 K were lower than those at 77 K. On the other hand, the FS of the smooth and the notched specimens for the forged Ti-6Al-4V ELI alloy at 4 K were lower than those for the rolled Ti-5Al-2.5Sn ELI alloy. This is considered to be the early initiation of the fatigue crack in the forged Ti-6Al-4V ELI alloy compares with the forged Ti-5Al-2.5Sn ELI.

  13. Evaluation of the stiffness and friction of Ti6Al4V ELI treated by glow discharge nitriding

    NASA Astrophysics Data System (ADS)

    Tavera, J. R.; Peña Ballesteros, D. Y.; Estupiñán Duran, H. A.

    2016-02-01

    In this study, an evaluation of the elastic-plastic surface hardening on Ti6Al4V ELI titanium nitride films obtained by glow discharge method was carried out by nanoindentation tests according to the standard ISO 14577. The nanotribological properties (metal-metal) were also evaluated using the pin-on-disc system Ti6Al4V surface deposition ELI with nitrogen, obtaining a correlation between the coefficient of friction of Ti6Al4V ELI treated by PVD and the Young's modulus of the respective substrate modified by PVD. To characterize the substrate for the characterization tests, scanning electron microscopy, atomic force microscopy and X-ray diffraction and contact angle were carried out. The results demonstrated that the substrates nitrided improved mechanical and tribological properties, hardness, Young's modulus and coefficient of friction, making the alloy Ti6Al4V ELI support axial loads in tension and compression.

  14. 6D phase space electron beam analysis and machine sensitivity studies for ELI-NP GBS

    NASA Astrophysics Data System (ADS)

    Giribono, A.; Bacci, A.; Curatolo, C.; Drebot, I.; Palumbo, L.; Petrillo, V.; Rossi, A. R.; Serafini, L.; Vaccarezza, C.; Vannozzi, A.; Variola, A.

    2016-09-01

    The ELI-NP Gamma Beam Source (GBS) is now under construction in Magurele-Bucharest (RO). Here an advanced source of gamma photons with unprecedented specifications of brilliance (>1021), monochromaticity (0.5%) and energy tunability (0.2-19.5 MeV) is being built, based on Inverse Compton Scattering in the head-on configuration between an electron beam of maximum energy 750 MeV and a high quality high power ps laser beam. These requirements make the ELI-NP GBS an advanced and challenging gamma ray source. The electron beam dynamics analysis and control regarding the machine sensitivity to the possible jitter and misalignments are presented. The effects on the beam quality are illustrated providing the basis for the alignment procedure and jitter tolerances.

  15. Laser-based acceleration for nuclear physics experiments at ELI-NP

    NASA Astrophysics Data System (ADS)

    Tesileanu, O.; Asavei, Th.; Dancus, I.; Gales, S.; Negoita, F.; Turcu, I. C. E.; Ursescu, D.; Zamfir, N. V.

    2016-05-01

    As part of the Extreme Light pan-European research infrastructure, Extreme Light Infrastructure - Nuclear Physics (ELI-NP) in Romania will focus on topics in Nuclear Physics, fundamental Physics and applications, based on very intense photon beams. Laser-based acceleration of electrons, protons and heavy ions is a prerequisite for a multitude of laser-driven nuclear physics experiments already proposed by the international research community. A total of six outputs of the dual-amplification chain laser system, two of 100TW, two of 1PW and two of 10PW will be employed in 5 experimental areas, with the possibility to use long and short focal lengths, gas and solid targets, reaching the whole range of laser acceleration processes. We describe the main techniques and expectations regarding the acceleration of electrons, protons and heavy nuclei at ELI-NP, and some physics cases for which these techniques play an important role in the experiments.

  16. Status of the ELIMED multidisciplinary and medical beam-line at ELI-Beamlines

    NASA Astrophysics Data System (ADS)

    Romano, F.; Cirrone, G. A. P.; Cuttone, G.; Schillaci, F.; Scuderi, V.; Amico, A.; Candiano, G.; Giordanengo, S.; Guarachi, L. F.; Korn, G.; Larosa, G.; Leanza, R.; Manna, R.; Marchese, V.; Marchetto, F.; Margarone, D.; Milluzzo, G.; Petringa, G.; Pipek, J.; Sacchi, R.; Vignati, A.

    2017-01-01

    Nowadays, one of the biggest challenges consists in using high intensity laser-target interaction to generate high-energy ions for medical purposes, eventually replacing the old paradigm of acceleration characterized by huge and complex machines. In order to investigate the feasibility of using laser-driven ion beams for multidisciplinary application, a dedicated beam transport line will be installed at the ELI-Beamlines facility in Prague (CZ), as a part of the User-oriented ELIMAIA beam-line dedicated to ion acceleration and their potential applications. The beam-line section dedicated to transport and dosimetric endpoints is called ELIMED (ELI-Beamlines MEDical and multidisciplinary applications) and will be developed by the INFN-LNS.

  17. Perspectives for neutron and gamma spectroscopy in high power laser driven experiments at ELI-NP

    NASA Astrophysics Data System (ADS)

    Negoita, F.; Gugiu, M.; Petrascu, H.; Petrone, C.; Pietreanu, D.; Fuchs, J.; Chen, S.; Higginson, D.; Vassura, L.; Hannachi, F.; Tarisien, M.; Versteegen, M.; Antici, P.; Balabanski, D.; Balascuta, S.; Cernaianu, M.; Dancus, I.; Gales, S.; Neagu, L.; Petcu, C.; Risca, M.; Toma, M.; Turcu, E.; Ursescu, D.

    2015-02-01

    The measurement of energy spectra of neutrons and gamma rays emitted by nuclei, together with charge particles spectroscopy, are the main tools for understanding nuclear phenomena occurring also in high power laser driven experiments. However, the large number of particles emitted in a very short time, in particular the strong X-rays flash produced in laser-target interaction, impose adaptation of technique currently used in nuclear physics experiment at accelerator based facilities. These aspects are discussed (Section 1) in the context of proposed studies at high power laser system of ELI-NP. Preliminary results from two experiments performed at Titan (LLNL) and ELFIE (LULI) facilities using plastic scintillators for neutron detection (Section 2) and LaBr3(Ce) scintillators for gamma detection (Section 3) are presented demonstrating the capabilities and the limitations of the employed methods. Possible improvements of these spectroscopic methods and their proposed implementation at ELI-NP will be discussed as well in the last section.

  18. Nuclear physics with advanced brilliant gamma beams at ELI-NP

    NASA Astrophysics Data System (ADS)

    Ur, Călin A.; Filipescu, Dan; Gheorghe, Ioana; Iancu, Violeta; Suliman, Gabriel; Teşileanu, Ovidiu

    2016-01-01

    The Extreme Light Infrastructure - Nuclear Physics facility is dedicated to nuclear physics studies with the use of extreme electromagnetic radiation. One of the main research system to be installed and operated in the facility is an outstanding high brilliance gamma beam system. The Gamma Beam System of ELI-NP will produce intense, quasi-monochromatic gamma beams via inverse Compton scattering of short laser pulses on relativistic electron beam pulses. The gamma beams available at ELI-NP will allow for the performance of photo-nuclear reactions aiming to reveal the intimate structure of the atomic nucleus. Nuclear Resonance Fluorescence, photo-fission, photo-disintegration reactions above the particle threshold will be used to study the dipole response of nuclei, the structure of the Pygmy resonances, nuclear processes relevant for astrophysics, production and study of exotic neutron-rich nuclei.

  19. The design and production of Ti-6Al-4V ELI customized dental implants

    NASA Astrophysics Data System (ADS)

    Chahine, Gilbert; Koike, Mari; Okabe, Toru; Smith, Pauline; Kovacevic, Radovan

    2008-11-01

    This paper addresses the production of customized Ti-6Al-4V ELI dental implants via electron beam melting (EBM). The melting of Ti-6Al-4V ELI powder produces implants with great biocompatibility, fi ne mechanical performance, and a high bone ingrowth potential. The EBM technology is used to produce one-component dental implants that mimic the exact shape of the patient’s tooth, replacing the traditional, three-component, “screw-like” standardized dental implants currently used. The new generation of implants provides the possibility of simplifying pre-insertion procedures leading to faster healing time, and the potential of better and stronger osseointegration, specifi cally through incorporating lattice structure design.

  20. Study of nuclear reactions in laser plasmas at future ELI-NP facility

    NASA Astrophysics Data System (ADS)

    Lanzalone, G.; Altana, C.; Anzalone, A.; Cappuzzello, F.; Cavallaro, M.; Gizzi, L. A.; Labate, L.; Lamia, L.; Mascali, D.; Muoio, A.; Negoita, F.; Odorici, F.; Petrascu, H.; Trifirò, A.; Trimarchi, M.; Tudisco, S.

    2016-05-01

    In this contribution we will present the future activities that our collaboration will carry out at ELI-NP (Extreme Light Infrastructure Nuclear Physics), the new multi peta-watt Laser facility, currently under construction at Bucharest (Romania). The activities concerns the study of nuclear reactions in laser plasmas. In this framework we proposed the construction of a new, general-purpose experimental set-up able to detect and identify neutrons and charged particles.

  1. ELYS regulates the localization of LBR by modulating its phosphorylation state

    PubMed Central

    Mimura, Yasuhiro; Takagi, Masatoshi; Clever, Michaela

    2016-01-01

    ABSTRACT Lamin B receptor (LBR), an inner nuclear membrane (INM) protein, contributes to the functional integrity of the nucleus by tethering heterochromatin to the nuclear envelope. We have previously reported that the depletion of embryonic large molecule derived from yolk sac (ELYS; also known as AHCTF1), a component of the nuclear pore complex, from cells perturbs the localization of LBR to the INM, but little is known about the underlying molecular mechanism. In this study, we found that the depletion of ELYS promoted LBR phosphorylation at the residues known to be phosphorylated by cyclin-dependent kinase (CDK) and serine/arginine protein kinases 1 and 2 (SRPK1 and SRPK2, respectively). These phosphorylation events were most likely to be counter-balanced by protein phosphatase 1 (PP1), and the depletion of PP1 from cells consistently caused the mislocalization of LBR. These observations point to a new mechanism regulating the localization of LBR, which is governed by an ELYS-mediated phosphorylation network. This phosphorylation-dependent coordination between INM proteins and the nuclear pore complex might be important for the integrity of the nucleus. PMID:27802161

  2. Overview on the target fabrication facilities at ELI-NP and ongoing strategies

    NASA Astrophysics Data System (ADS)

    Gheorghiu, C. C.; Leca, V.; Popa, D.; Cernaianu, M. O.; Stutman, D.

    2016-10-01

    Along with the development of petawatt class laser systems, the interaction between high power lasers and matter flourished an extensive research, with high-interest applications like: laser nuclear physics, proton radiography or cancer therapy. The new ELI-NP (Extreme Light Infrastructure - Nuclear Physics) petawatt laser facility, with 10PW and ~ 1023W/cm2 beam intensity, is one of the innovative projects that will provide novel research of fundamental processes during light-matter interaction. As part of the ELI-NP facility, Targets Laboratory will provide the means for in-house manufacturing and characterization of the required targets (mainly solid ones) for the experiments, in addition to the research activity carried out in order to develop novel target designs with improved performances. A description of the Targets Laboratory with the main pieces of equipment and their specifications are presented. Moreover, in view of the latest progress in the target design, one of the proposed strategies for the forthcoming experiments at ELI-NP is also described, namely: ultra-thin patterned foil of diamond-like carbon (DLC) coated with a carbon-based ultra-low density layer. The carbon foam which behaves as a near-critical density plasma, will allow the controlled-shaping of the laser pulse before the main interaction with the solid foil. Particular emphasis will be directed towards the target's design optimization, by simulation tests and tuning the key-properties (thickness/length, spacing, density foam, depth, periodicity etc.) which are expected to have a crucial effect on the laser-matter interaction process.

  3. Design and simulation of a pulsed positron beam at ELI-NP

    NASA Astrophysics Data System (ADS)

    Djourelov, N.; Dinescu, D.

    2017-01-01

    The design of the pulsing system for the slow e+ beam at ELI-NP is presented. It will deliver narrow time width e+ pulses, achieved by a combination of prebuncher, chopper and buncher. The effect of the different components on the pulse compression is simulated by a Matlab program. The results show that the best compression of the e+ pulses, which can be achieved by the proposed pulsing system, is limited to about 100 ps (FWHM). The most effective solution, applied up to now, for minimizing the influence of the backscattered e+ on the PALS spectra by using a bent tube filter is simulated by Comsol Multiphysics.

  4. Cryogenic stopping cell for photofission fragments at the ELI-NP facility

    NASA Astrophysics Data System (ADS)

    Constantin, P.; Balabanski, D. L.; Cuong, P. V.

    2015-10-01

    The brilliant gamma beam at the future Extreme Light Infrastructure - Nuclear Physics (ELI-NP) facility will be used to generate a beam of exotic neutron-rich isotopes via photofission of actinide targets. We present simulations with the Geant4 toolkit of the photofission process for the design and optimization of the expected performance parameters of the Cryogenic Stopping Cell (CSC). The CSC will be used to extract the photofission fragments into the secondary beam of about 106 ions/s. We propose an experimental program to study refractory neutron-rich isotopes.

  5. Cryogenic stopping cell for photofission fragments at the ELI-NP facility

    SciTech Connect

    Constantin, P. Balabanski, D. L.; Cuong, P. V.

    2015-10-15

    The brilliant gamma beam at the future Extreme Light Infrastructure - Nuclear Physics (ELI-NP) facility will be used to generate a beam of exotic neutron-rich isotopes via photofission of actinide targets. We present simulations with the Geant4 toolkit of the photofission process for the design and optimization of the expected performance parameters of the Cryogenic Stopping Cell (CSC). The CSC will be used to extract the photofission fragments into the secondary beam of about 10{sup 6} ions/s. We propose an experimental program to study refractory neutron-rich isotopes.

  6. 100-J level amplifier concepts for HiLASE and ELI-Beamlines

    NASA Astrophysics Data System (ADS)

    Sikocinski, P.; Divoky, M.; Lucianetti, A.; Sawicka, M.; Novak, J.; Rus, B.; Mocek, T.

    2012-07-01

    We present comparison of two alternative layouts of a 100 J cryogenically cooled Yb:YAG multi-slab laser system operating at 10 Hz for HiLASE and ELI Beamlines projects. In the first approach, the 100 J slab amplifier consists of a preamplifier and power amplifier, while in the second approach it uses single power amplifier with two amplifier heads. These two concepts are compared, with respect to output power, B-integral, accumulated B-integral, and peak fluence. Results are obtained by simulating beam propagation in MIRÓ code and calculating stored energy in the amplifier by homemade ray-tracing MATLAB code for amplified spontaneous emission evaluation.

  7. Status of the project for a positron laboratory at ELI-NP

    NASA Astrophysics Data System (ADS)

    Djourelov, N.; Oprisa, A.; Dinescu, D.; Leca, V.

    2017-01-01

    We report on the plans of a positron laboratory to be built at the Extreme Light Infrastructure - Nuclear Physics (ELI-NP) facility. The slow e+ source is based on e‑–e+ pair production in a converter made of tungsten foils by a brilliant gamma beam (Eγ<3.5 MeV, Iγ = 2.4×1010 γ s-1) which will be generated by Compton back–scattering of photons from a high power laser on electrons from a LINAC. Numerical simulations of γ–ray interactions with the designed converter showed that, if the tungsten foils are used for moderation of the created fast e+, a slow e+ beam of an intensity of ~1×106 s-1 can be obtained. Circular polarization of the γ-beam is proposed to be one of the ELI-NP’s upgrades. The slow e+ will be extracted perpendicularly to the γ–beam and will have ~ 30% transversal polarization degree. By using a transmission re-moderation stage and electrostatically turning the re–moderated beam by 90°, the transversal polarization will be changed to longitudinal. Longitudinal polarization can then be preserved in the longitudinal magnetic guiding field. The heat load to the converter was estimated at < 2 mW which implies that e+ moderation by frozen neon is applicable.

  8. Perspectives for neutron and gamma spectroscopy in high power laser driven experiments at ELI-NP

    SciTech Connect

    Negoita, F. Gugiu, M. Petrascu, H. Petrone, C. Pietreanu, D.; Fuchs, J.; Chen, S.; Higginson, D.; Vassura, L.; Hannachi, F.; Tarisien, M.; Versteegen, M.; Antici, P.; Balabanski, D.; Balascuta, S.; Cernaianu, M.; Dancus, I.; Gales, S.; Neagu, L.; Petcu, C.; and others

    2015-02-24

    The measurement of energy spectra of neutrons and gamma rays emitted by nuclei, together with charge particles spectroscopy, are the main tools for understanding nuclear phenomena occurring also in high power laser driven experiments. However, the large number of particles emitted in a very short time, in particular the strong X-rays flash produced in laser-target interaction, impose adaptation of technique currently used in nuclear physics experiment at accelerator based facilities. These aspects are discussed (Section 1) in the context of proposed studies at high power laser system of ELI-NP. Preliminary results from two experiments performed at Titan (LLNL) and ELFIE (LULI) facilities using plastic scintillators for neutron detection (Section 2) and LaBr{sub 3}(Ce) scintillators for gamma detection (Section 3) are presented demonstrating the capabilities and the limitations of the employed methods. Possible improvements of these spectroscopic methods and their proposed implementation at ELI-NP will be discussed as well in the last section.

  9. Strong field physics and QED experiments with ELI-NP 2×10PW laser beams

    SciTech Connect

    Turcu, I. C. E. Balascuta, S. Negoita, F.; Jaroszynski, D.; McKenna, P.

    2015-02-24

    The ELI-NP facility will focus a 10 PW pulsed laser beam at intensities of ∼10{sup 23} W/cm{sup 2} for the first time, enabling investigation of the new physical phenomena at the interfaces of plasma, nuclear and particle physics. The electric field in the laser focus has a maximum value of ∼10{sup 15} V/m at such laser intensities. In the ELI-NP Experimental Area E6, we propose the study of Radiation Reaction, Strong Field Quantum Electrodynamics (QED) effects and resulting production of Ultra-bright Sources of Gamma-rays which could be used for nuclear activation. Two powerful, synchronized 10 PW laser beams will be focused in the E6 Interaction Chamber on either gas or solid targets. One 10 PW beam is the Pump-beam and the other is the Probe-beam. The focused Pump beam accelerates the electrons to relativistic energies. The accelerated electron bunches interact with the very high electro-magnetic field of the focused Probe beam. The layout of the experimental area E6 will be presented with several options for the experimental configurations.

  10. Identification of Conserved MEL-28/ELYS Domains with Essential Roles in Nuclear Assembly and Chromosome Segregation

    PubMed Central

    Hirano, Yasuhiro; Mauro, Michael; Lai, Allison; Ayuso, Cristina; Haraguchi, Tokuko; Hiraoka, Yasushi; Piano, Fabio

    2016-01-01

    Nucleoporins are the constituents of nuclear pore complexes (NPCs) and are essential regulators of nucleocytoplasmic transport, gene expression and genome stability. The nucleoporin MEL-28/ELYS plays a critical role in post-mitotic NPC reassembly through recruitment of the NUP107-160 subcomplex, and is required for correct segregation of mitotic chromosomes. Here we present a systematic functional and structural analysis of MEL-28 in C. elegans early development and human ELYS in cultured cells. We have identified functional domains responsible for nuclear envelope and kinetochore localization, chromatin binding, mitotic spindle matrix association and chromosome segregation. Surprisingly, we found that perturbations to MEL-28’s conserved AT-hook domain do not affect MEL-28 localization although they disrupt MEL-28 function and delay cell cycle progression in a DNA damage checkpoint-dependent manner. Our analyses also uncover a novel meiotic role of MEL-28. Together, these results show that MEL-28 has conserved structural domains that are essential for its fundamental roles in NPC assembly and chromosome segregation. PMID:27341616

  11. Identification of Conserved MEL-28/ELYS Domains with Essential Roles in Nuclear Assembly and Chromosome Segregation.

    PubMed

    Gómez-Saldivar, Georgina; Fernandez, Anita; Hirano, Yasuhiro; Mauro, Michael; Lai, Allison; Ayuso, Cristina; Haraguchi, Tokuko; Hiraoka, Yasushi; Piano, Fabio; Askjaer, Peter

    2016-06-01

    Nucleoporins are the constituents of nuclear pore complexes (NPCs) and are essential regulators of nucleocytoplasmic transport, gene expression and genome stability. The nucleoporin MEL-28/ELYS plays a critical role in post-mitotic NPC reassembly through recruitment of the NUP107-160 subcomplex, and is required for correct segregation of mitotic chromosomes. Here we present a systematic functional and structural analysis of MEL-28 in C. elegans early development and human ELYS in cultured cells. We have identified functional domains responsible for nuclear envelope and kinetochore localization, chromatin binding, mitotic spindle matrix association and chromosome segregation. Surprisingly, we found that perturbations to MEL-28's conserved AT-hook domain do not affect MEL-28 localization although they disrupt MEL-28 function and delay cell cycle progression in a DNA damage checkpoint-dependent manner. Our analyses also uncover a novel meiotic role of MEL-28. Together, these results show that MEL-28 has conserved structural domains that are essential for its fundamental roles in NPC assembly and chromosome segregation.

  12. Strain-based fatigue data for Ti-6Al-4V ELI under fully-reversed and mean strain loads.

    PubMed

    Carrion, Patricio E; Shamsaei, Nima

    2016-06-01

    This article presents the experimental data supporting the study to obtain the mean strain/stress effects on the fatigue behavior of Ti-6Al-4V ELI. A series of strain-controlled fatigue experiments on Ti-6Al-4V ELI were performed at four strain ratios (-1, -0.5, 0, and 0.5). Two types of data are included for each specimen. These are the hysteresis stress-strain responses for the cycle in a log10 increment, and the maximum and minimum stress-strain responses for each cycle. Fatigue lives are also reported for all the experiments.

  13. Strain-based fatigue data for Ti–6Al–4V ELI under fully-reversed and mean strain loads

    PubMed Central

    Carrion, Patricio E.; Shamsaei, Nima

    2016-01-01

    This article presents the experimental data supporting the study to obtain the mean strain/stress effects on the fatigue behavior of Ti–6Al–4V ELI. A series of strain-controlled fatigue experiments on Ti–6Al–4V ELI were performed at four strain ratios (−1, −0.5, 0, and 0.5). Two types of data are included for each specimen. These are the hysteresis stress–strain responses for the cycle in a log10 increment, and the maximum and minimum stress–strain responses for each cycle. Fatigue lives are also reported for all the experiments. PMID:26952022

  14. The Implications of John Hart Ely's Conceptual Framework for Interpretation of First Amendment Questions: The Continuation of Balancing in the Free Expression Arena.

    ERIC Educational Resources Information Center

    Trapp, Mary E.

    Examining interpretive approaches to the First Amendment free speech and press clause, this paper focuses on the conceptual framework proposed by John Hart Ely. Other First Amendment tests examined include clear and present danger, balancing, the absolute test, and A. Meiklejohn's "absolute" test. Following an analysis of Ely's First…

  15. ELI/SBP'S UVB (VACUUM VAPORIZATION WELL) SYSTEM FOR TREATMENT OF VOC-CONTAMINATED SOILS; INNOVATIVE TECHNOLOGY EVALUATION REPORT

    EPA Science Inventory

    This report summarizes the findings of an evaluation of the Unterdruck-Verdampfer-Brunnen (UVB) technology developed by IEG Technologies (IEG) and licensed in the eastern United States by Environmental Laboratories, Inc. (ELI) and SBP Technologies (SBP). This evaluation was cond...

  16. Data on ground-water quality for the Ely 1 degree x 2 degree quadrangle, eastern Nevada

    USGS Publications Warehouse

    Welch, Alan H.; Williams, Rhea P.

    1986-01-01

    Water quality data for groundwater were compiled for the Ely 1 degree x 2 degree quadrangle which covers a portion of eastern Nevada. Chemical characteristics of the water are shown on a map (at a scale of 1:250,000) and on trilinear diagrams for the major ions. The data for the area are also presented in a table. (USGS)

  17. Eli Whitney's Patent for the Cotton Gin. The Constitution Community: Revolution and the New Nation (1754-1820s).

    ERIC Educational Resources Information Center

    Schur, Joan Brodsky

    This lesson focuses on the power of the U.S. Congress to pass laws related to issuing patents. Using Eli Whitney's 1812 Congressional petition to extend the patent on his cotton gin as an example, the lesson correlates to the National History Standards and the National Standards for Civics and Government. It contains two primary source documents,…

  18. National uranium resource evaluation program: hydrogeochemical and stream sediment reconnaissance basic data for Ely quadrangle, Nevada; Utah

    SciTech Connect

    Not Available

    1981-10-15

    Field and laboratory data are presented for 1937 sediment samples from the Ely Quadrangle, Nevada; Utah. The samples were collected by Savannah River Laboratory; laboratory analysis and data reporting were performed by the Uranium Resource Evaluation Project at Oak Ridge, Tennessee.

  19. CFL Labeling Harmonization in the United States, China, Brazil andELI Member Countries: Specifications, Testing, and MutualRecognition

    SciTech Connect

    Fridley, David; Lin, Jiang; Denver, Andrea; Biermayer, Peter; Dillavou, Tyler

    2005-07-20

    This report examines critical differences among energy-efficient labeling programs for CFLs in Brazil, China, the United States, and the seven members of the international Efficient Lighting Initiative (ELI) in terms of technical specifications and test procedures, and review issues related to international harmonization of these standards.

  20. ELI-Beamlines: development of next generation short-pulse laser systems

    NASA Astrophysics Data System (ADS)

    Rus, B.; Bakule, P.; Kramer, D.; Naylon, J.; Thoma, J.; Green, J. T.; Antipenkov, R.; Fibrich, M.; Novák, J.; Batysta, F.; Mazanec, T.; Drouin, M. A.; Kasl, K.; Baše, R.; Peceli, D.; Koubíková, L.; Trojek, P.; Boge, R.; Lagron, J. C.; Vyhlídka, Å.; Weiss, J.; Cupal, J.,; Hřebíček, J.; Hříbek, P.; Durák, M.; Polan, J.; Košelja, M.; Korn, G.; Horáček, M.; Horáček, J.; Himmel, B.; Havlíček, T.; Honsa, A.; Korouš, P.; Laub, M.; Haefner, C.; Bayramian, A.; Spinka, T.; Marshall, C.; Johnson, G.; Telford, S.; Horner, J.; Deri, B.; Metzger, T.; Schultze, M.; Mason, P.; Ertel, K.; Lintern, A.; Greenhalgh, J.; Edwards, C.; Hernandez-Gomez, C.; Collier, J.; Ditmire, T.,; Gaul, E.; Martinez, M.; Frederickson, C.; Hammond, D.; Malato, C.; White, W.; Houžvička, J.

    2015-05-01

    Overview of the laser systems being built for ELI-Beamlines is presented. The facility will make available high-brightness multi-TW ultrashort laser pulses at kHz repetition rate, PW 10 Hz repetition rate pulses, and kilojoule nanosecond pulses for generation of 10 PW peak power. The lasers will extensively employ the emerging technology of diode-pumped solid-state lasers (DPSSL) to pump OPCPA and Ti:sapphire broadband amplifiers. These systems will provide the user community with cutting-edge laser resources for programmatic research in generation and applications of high-intensity X-ray sources, in particle acceleration, and in dense-plasma and high-field physics.

  1. Positron production at extreme light infrastructure – nuclear physics (ELI-NP)

    SciTech Connect

    Oprisa, A. Balascuta, S. Ur, C. A.

    2015-02-24

    Applied and material physics studies with positron beams of Fermi–surfaces, defects, interfaces etc. offer excellent diagnostics tools. At ELI-NP, an intense γ beam of about 10{sup 11} photons/s with energies up to 3.5 MeV will be used to generate a positron beam via pair production in a tungsten converter target. To obtain a high intensity beam of moderated positrons the design of the positron source is of high importance. The design of a dedicated positron source at ELI–NP is being investigated based on extensive GEANT4 simulations. The goal of the simulations is to optimize the geometry of the target and the gamma beam collimation. We present here the characteristics of the positron beam obtained for different geometries of the converter target.

  2. A conceptual design of an electron spectrometer for ELI-NP

    SciTech Connect

    Balascuta, S. Turcu, I. C. E.

    2015-02-24

    We present the geometry and field parameters of an Electron Spectrometer (ES) with two dipole magnets, considered for electron energy measurements at the High Fields QED experimental area at ELI-NP. The first magnet is a 2 meter long permanent magnet, placed inside the Interaction Chamber (IC). The second magnet is a 1.5 meters long electromagnet, placed outside IC. The pulsed electron beam will be produced by the 10 PW pulsed Laser, ‘pump-beam’, focused into one meter long capillary low density plasma cell. A second 10 PW pulsed Laser, ‘probe-beam’, will interact with the relativistic electron bunch providing the strong electromagnetic field. The ES will measure the subtle changes in the electron energy spectrum as a result of the electron beam interaction with the probe-beam field.

  3. A Journey with Elie Metchnikoff: From Innate Cell Mechanisms in Infectious Diseases to Quantum Biology

    PubMed Central

    Merien, Fabrice

    2016-01-01

    Many reviews of Elie Metchnikoff’s work have been published, all unanimously acknowledging the significant contributions of his cellular theory to the fields of immunology and infectious diseases. In 1883, he published a key paper describing phagocytic cells in frogs. His descriptions were not just about phagocytes involved in host defense, he also described how these specialized cells eliminated degenerating or dying cells of the host. This perspective focuses on key concepts developed by Metchnikoff by presenting relevant excerpts of his 1883 paper and matching these concepts with challenges of modern immunology. A new approach to macrophage polarization is included to introduce some creative thinking about the exciting emerging area of quantum biology. PMID:27379227

  4. Electron beam loss assumptions for ELI-NPMEGa-ray radioprotection analysis

    SciTech Connect

    Deis, G A

    2011-10-06

    The ELI-NP project is now working on the design of their conventional facility. Dr. Gheorghe Cata-Danil recently requested that I provide them with information on the location and amount of electron-beam loss in the MEGa-ray source they have proposed for ELI-NP. This memo is intended to document that information, for transmission to ELI-NP. The ELI-NP MEGa-ray source, as presently proposed, consists of two x-band accelerator sections separated by a large chicane, as show in figure 1. The basic parameters of the machine that are pertinent for specifying the radiation source terms are shown in table 1. These are the parameters of the intentionall-produced photobeam. In addition to the photobeam, the electron gun and accelerator will produce 'dark current' that originates throughout the RF structures (that is, distributed along the accelerator axis) and therefore has a distribution of energy below the energy of the photobeam. Because it is emitted from surfaces inside the RF structures, much of it is not transported through the accelerator and is lost in the accelerator RF structures. A large fraction of the total dark current is produced in the photogun and lost at the entrance of the 1st accelerator RF structure. Important sources of radiation during operation are beam alignment screens that are used for observing the image of the electron beam, during adjustment of beam steering and for general diagnostic purposes. Each screen consists of a 1 mm thick Ce:YAG plate that is moved into the path of the beam when desired. This destroys the electron beam, spraying all beam current into the structures downstream of the screen. Only one screen is inserted at a time. These screens may be located after each accelerator RF structure, and after each set of bend magnets, as shown in figure 3. The photobeam energy and currents at each location are listed in table 2; for simplicity, the dark current energy is (conseratively) assumed to be the same as the photobeam energy. In

  5. Effects of radiation damping on the dynamics of electrons in ELI intensity laser fields

    NASA Astrophysics Data System (ADS)

    Harvey, Christopher; Marklund, Mattias

    2012-07-01

    An electron in the presence of a high intensity laser field, such as that anticipated at ELI, will be accelerated so strongly that its own radiation emission may significantly affect its motion. This opens up the possibility of testing experimentally the classical theory of radiation reaction in such a context. We therefore explore the effects of radiation damping on the dynamics of electrons in optical laser pulses. In the case of high intensities and high initial electron energies, the trajectories and net energy changes of the electrons are found to be significantly altered. These effects are found to become increasingly significant the closer one gets to a directly head on collision between the laser and electrons.

  6. Design of the gas cell for the IGISOL facility at ELI-NP

    NASA Astrophysics Data System (ADS)

    Constantin, P.; Balabanski, D. L.; Anh, L. T.; Cuong, P. V.; Mei, B.

    2017-04-01

    One of the experimental programs that will be carried out at the Extreme Light Infrastructure - Nuclear Physics (ELI-NP) facility is the production of exotic neutron-rich ion beams in an IGISOL facility via photofission in a stack of actinide targets placed at the center of a cell filled with He gas. Simulations with the Geant4 toolkit were done for the optimization of the target configuration that maximizes the rate of released photofission fragments. The cell geometry is established based on the stopping properties of these fragments. Studies, based on simulations with Geant4 and SIMION 8.1, of the space charge effect and its induced electric field in the gas cell are presented. Estimates of the extraction time and efficiency of the photofission fragments are derived.

  7. Watershed Academy Webcast - ELI/TNC Watershed Approach Handbook: Improving Outcomes and Increasing Benefits Associated with Wetland and Stream Restoration and Protection Projects

    EPA Pesticide Factsheets

    Flyer, presentation, and additional resources for the March 18, 2015 webcast, ELI/TNC Watershed Approach Handbook: Improving Outcomes and Increasing Benefits Associated with Wetland and Stream Restoration and Protection Projects

  8. Nuclear Physics with 10 PW laser beams at Extreme Light Infrastructure - Nuclear Physics (ELI-NP)

    NASA Astrophysics Data System (ADS)

    Zamfir, N. V.

    2014-05-01

    The field of the uncharted territory of high-intensity laser interaction with matter is confronted with new exotic phenomena and, consequently, opens new research perspectives. The intense laser beams interacting with a gas or solid target generate beams of electrons, protons and ions. These beams can induce nuclear reactions. Electrons also generate ions high-energy photons via bremsstrahlung processes which can also induce nuclear reactions. In this context a new research domain began to form in the last decade or so, namely nuclear physics with high power lasers. The observation of high brilliance proton beams of tens of MeV energy from solid targets has stimulated an intense research activity. The laser-driven particle beams have to compete with conventional nuclear accelerator-generated beams. The ultimate goal is aiming at applications of the laser produced beams in research, technology and medicine. The mechanism responsible for ion acceleration are currently subject of intensive research in many laboratories in the world. The existing results, experimental and theoretical, and their perspectives are reviewed in this article in the context of IZEST and the scientific program of ELI-NP.

  9. Ultrafast beam dump materials and mirror coatings tested with the ELI beamlines LIDT test station

    NASA Astrophysics Data System (ADS)

    Durák, Michal; Kramer, Daniel; Velpula, Praveen K.; Cupal, Josef; Medřík, TomáÅ.¡; Hřebíček, Jan; Golasowski, Jiří; Peceli, Davorin; Fekete, Ladislav; Å tepán, Václav; Kozlová, Michaela; Rus, Bedřich

    2015-11-01

    The ELI Beamlines project will deliver ultrafast laser pulses with peak powers up to 10PW available every minute and PW class beams at 10Hz complemented by a 10TW 1kHz beamline. To properly determine damage thresholds of involved optical components in conditions similar to the operational environment and with expected laser parameters, a high vacuum LIDT test station was constructed at PALS facility. Our study presents results of ISO based S-on-1 and R-on-1 tests in femtosecond regime (50fs, 800nm, 10Hz/1kHz) performed on two different types of coatings: a) highabsorption black coatings with low outgassing rates, intended for use as a beam dump surface; and b) high-reflectivity, low-dispersion 45° AOI ultrafast mirror coatings. Testing of absorptive coatings was accompanied with QMS residual gas analysis to verify, that high intensity laser radiation approaching the damage threshold does not increase concentration of volatile organic compounds in the vacuum chamber. In case of HR mirror coatings, we also investigate the effect of cleaning on LIDT value, comparing characteristic S-on-1 curves of given sample with values obtained after 12h immersion in ethanol-water solution.

  10. Benthic macroinvertebrate assemblages and sediment toxicity testing in the Ely Creek watershed restoration project

    SciTech Connect

    Soucek, D.J.; Currie, R.J.; Cherry, D.S.; Latimer, H.A.; Trent, G.C.

    1998-12-31

    The Ely Creek watershed in Lee County, Virginia, contains an abundance of abandoned mined land (AML) seeps that contaminate the majority of the creek and its confluence into Big Stone Creek. Contaminated sediments had high concentrations of iron ({approximately}10,000 mg/kg), aluminum ({approximately}1,500 mg/kg), magnesium ({approximately}400 mg/kg) and manganese ({approximately}150 mg/kg). Copper and zinc generally ranged from 3 to 20 mg/kg. Benthic macroinvertebrates surveys at six of 20 sites sampled in the watershed yielded no macroinvertebrates, while eight others had total abundances of 1 to 9 organisms. Four reference sites contained {ge}100 organisms and at least 14 different taxa. Laboratory, 10-day survival/impairment sediments tests with Daphnia magna did not support the field data. Mortality of 92 to 100% for D. magna occurred in samples collected from six cities. Daphnid reproduction was more sensitive than laboratory test organism survivorship; however, neither daphnid survivorship nor reproduction were good predictors of taxa richness. Laboratory test concerns included the use of a reference diluent water rather than site specific diluent water.

  11. Centenary of the death of Elie Metchnikoff: a visionary and an outstanding team leader.

    PubMed

    Cavaillon, Jean-Marc; Legout, Sandra

    2016-10-01

    Elie Metchnikoff passed away on July 15th, 1916. He is considered to be the father of phagocytes, cellular innate immunity, probiotics, and gerontology. In all of these fields, he was a visionary. To achieve such a notability and produce so many masterpieces, Metchnikoff used more than 30 animal species to support his findings, and his pasteurian laboratory published more than 200 papers in the Annales de l'Institut Pasteur. As a wonderful team leader and a great mentor, during his 28 years at Institut Pasteur, he welcomed and supervised more than 100 young trainees. Trained as an embryologist, he contributed to the birth of immunology and to the understanding of physiology and pathology. Indeed, Metchnikoff and his team investigated inflammation in guinea pigs, rats, frogs; studied infectious diseases in monkeys, caimans, geese; investigated aging in parrots, dogs, humans; proposed hypotheses to understand age-associated senility using rabbits and humans; developed germ free tadpoles, flies, chicks; studied the gut flora in bats, horses, birds, humans; and popularized the use of probiotics as a tool to delay the deleterious effects of toxic compounds derived from putrefactive gut bacteria. He was also a philosopher and penned essays on human disharmony and on pessimism and optimism.

  12. Copper speciation in variably toxic sediments at the Ely Copper Mine, Vermont, United States

    USGS Publications Warehouse

    Kimball, Bryn E.; Foster, Andrea L.; Seal II, Robert R.; Piatak, Nadine M.; Webb, Samuel M.; Hammarstrom, Jane M.

    2016-01-01

    At the Ely Copper Mine Superfund site, Cu concentrations exceed background values in both streamwater (160–1200 times) and sediments (15–79 times). Previously, these sediment samples were incubated with laboratory test organisms, and they exhibited variable toxicity for different stream sites. In this study we combined bulk- and microscale techniques to determine Cu speciation and distribution in these contaminated sediments on the basis of evidence from previous work that Cu was the most important stressor in this environment and that variable observed toxicity could have resulted from differences in Cu speciation. Copper speciation results were similar at microscopic and bulk scales. The major Cu species in the more toxic samples were sorbed or coprecipitated with secondary Mn (birnessite) and Fe minerals (jarosite and goethite), which together accounted for nearly 80% of the total Cu. The major Cu species in the less toxic samples were Cu sulfides (chalcopyrite and a covellite-like phase), making up about 80–95% of the total Cu, with minor amounts of Cu associated with jarosite or goethite. These Cu speciation results are consistent with the toxicity results, considering that Cu sorbed or coprecipitated with secondary phases at near-neutral pH is relatively less stable than Cu bound to sulfide at lower pH. The more toxic stream sediment sites were those that contained fewer detrital sulfides and were upstream of the major mine waste pile, suggesting that removal and consolidation of sulfide-bearing waste piles on site may not eliminate all sources of bioaccessible Cu.

  13. Copper Speciation in Variably Toxic Sediments at the Ely Copper Mine, Vermont, United States.

    PubMed

    Kimball, Bryn E; Foster, Andrea L; Seal, Robert R; Piatak, Nadine M; Webb, Samuel M; Hammarstrom, Jane M

    2016-02-02

    At the Ely Copper Mine Superfund site, Cu concentrations exceed background values in both streamwater (160-1200 times) and sediments (15-79 times). Previously, these sediment samples were incubated with laboratory test organisms, and they exhibited variable toxicity for different stream sites. In this study we combined bulk- and microscale techniques to determine Cu speciation and distribution in these contaminated sediments on the basis of evidence from previous work that Cu was the most important stressor in this environment and that variable observed toxicity could have resulted from differences in Cu speciation. Copper speciation results were similar at microscopic and bulk scales. The major Cu species in the more toxic samples were sorbed or coprecipitated with secondary Mn (birnessite) and Fe minerals (jarosite and goethite), which together accounted for nearly 80% of the total Cu. The major Cu species in the less toxic samples were Cu sulfides (chalcopyrite and a covellite-like phase), making up about 80-95% of the total Cu, with minor amounts of Cu associated with jarosite or goethite. These Cu speciation results are consistent with the toxicity results, considering that Cu sorbed or coprecipitated with secondary phases at near-neutral pH is relatively less stable than Cu bound to sulfide at lower pH. The more toxic stream sediment sites were those that contained fewer detrital sulfides and were upstream of the major mine waste pile, suggesting that removal and consolidation of sulfide-bearing waste piles on site may not eliminate all sources of bioaccessible Cu.

  14. The mineral magnetic record of magnetofossils in recent lake sediments of Lake Ely, PA

    NASA Astrophysics Data System (ADS)

    Kodama, K. P.; Moeller, R. E.; Bazylinski, D. A.; Kopp, R. E.; Chen, A. P.

    2013-11-01

    Mineral magnetic and ferromagnetic resonance (FMR) measurements made on the sediments from Lake Ely, Pennsylvania reveal the presence of magnetotactic bacteria magnetofossils. Saturation isothermal remanent magnetization (SIRM) data from a 1.25 m long piston core taken from the deepest part of the lake show a large intensity decrease at depths between 30 and 75 cm in the sediment column most likely the result of reductive diagenesis. Modeling of isothermal remanent magnetization (IRM) and anhysteretic remanent magnetization (ARM) acquisition data indicates the presence of biogenic soft (BS) and biogenic hard (BH) magnetosome coercivity components, even at depths in the core greatly affected by reductive diagenesis. First-order reversal curve distribution diagrams for two samples support this interpretation. Modeling of the FMR data also indicates the presence of the BS and BH magnetosome coercivity components, but the relative importance of the two components is opposite to that seen for the IRM and ARM acquisition modeling. A correlation between SIRM variations and local rainfall recorded over the past 70 years suggests that magnetofossil concentrations recorded paleo-rainfall variations in the most recent lake sediments. Multi-taper method spectral analysis of SIRM variations in the piston core, tied to time by varve counting from 1600 common era (CE) to 1128 before CE, show centennial scale periodicities similar to those observed in spectral analysis of a 230 year long historical rainfall record for the northeastern US reconstructed to Philadelphia, PA. This result indicates that enough magnetofossils can survive reductive diagenesis to retain a record of paleorainfall variations, suggesting that they can be a powerful paleoclimate proxy.

  15. The effect of weld porosity on the cryogenic fatigue strength of ELI grade Ti-5Al-2. 5Sn

    SciTech Connect

    Rogers, P.R.; Lambdin, R.C.; Fox, D.E.

    1992-09-01

    The effect of weld porosity on the fatigue strength of ELI grade Ti-5Al-2.5Sn at cryogenic temperature was determined. A series of high cycle fatigue (HCF) and tensile tests were performed at -320 F on specimens made from welded sheets of the material. All specimens were tested with weld beads intact and some amount of weld offset. Specimens containing porosity and control specimens containing no porosity were tested. Results indicate that for the weld configuration tested, the fatigue life of the material is not affected by the presence of spherical embedded pores.

  16. The effect of weld porosity on the cryogenic fatigue strength of ELI grade Ti-5Al-2.5Sn

    NASA Technical Reports Server (NTRS)

    Rogers, P. R.; Lambdin, R. C.; Fox, D. E.

    1992-01-01

    The effect of weld porosity on the fatigue strength of ELI grade Ti-5Al-2.5Sn at cryogenic temperature was determined. A series of high cycle fatigue (HCF) and tensile tests were performed at -320 F on specimens made from welded sheets of the material. All specimens were tested with weld beads intact and some amount of weld offset. Specimens containing porosity and control specimens containing no porosity were tested. Results indicate that for the weld configuration tested, the fatigue life of the material is not affected by the presence of spherical embedded pores.

  17. Regulating Direct-to-Consumer Drug Information: A Case Study of Eli Lilly's Canadian 40over40 Erectile Dysfunction Campaign

    PubMed Central

    Williams-Jones, Bryn

    2015-01-01

    Like most jurisdictions, Canada prohibits direct-to-consumer advertising (DTCA) of prescribed drugs. However, direct-to-consumer information (DTCI) is permitted, allowing companies to inform the public about medical conditions. An analysis of Eli Lilly's 40over40 promotion campaign for erectile dysfunction (ED), which included a quiz on ED, shows that DTCI, like DTCA, can be an effective means of drug familiarization. The pharmaceutical industry is “playing by the rules” currently in effect in Canada. Regulators should thus seriously consider whether existing rules permitting DTCI actually meet stated objectives of protecting the public from marketing campaigns (i.e., DTCA) that may deliver misleading information. PMID:26142356

  18. Front end for high-repetition rate thin disk-pumped OPCPA beamline at ELI-beamlines

    NASA Astrophysics Data System (ADS)

    Green, Jonathan T.; Novák, Jakub; Antipenkov, Roman; Batysta, František; Zervos, Charalampos; Naylon, Jack A.; Mazanec, TomáÅ.¡; Horáček, Martin; Bakule, Pavel; Rus, Bedřich

    2015-02-01

    The ELI-Beamlines facility, currently under construction in Prague, Czech Republic, will house multiple high power laser systems with varying pulse energies, pulse durations, and repetition rates. Here we present the status of a high repetition rate beamline currently under construction with target parameters of 20 fs pulse duration, 100 mJ pulse energy, and 1 kHz repetition rate. Specifically we present the Yb:YAG thin disk lasers which are intended to pump picosecond OPCPA, synchronization between pump and signal pulses in the OPCPA, and the first stages of OPCPA.

  19. Regulating Direct-to-Consumer Drug Information: A Case Study of Eli Lilly's Canadian 40over40 Erectile Dysfunction Campaign.

    PubMed

    Pipon, Jean-Christophe Bélisle; Williams-Jones, Bryn

    2015-05-01

    Like most jurisdictions, Canada prohibits direct-to-consumer advertising (DTCA) of prescribed drugs. However, direct-to-consumer information (DTCI) is permitted, allowing companies to inform the public about medical conditions. An analysis of Eli Lilly's 40over40 promotion campaign for erectile dysfunction (ED), which included a quiz on ED, shows that DTCI, like DTCA, can be an effective means of drug familiarization. The pharmaceutical industry is "playing by the rules" currently in effect in Canada. Regulators should thus seriously consider whether existing rules permitting DTCI actually meet stated objectives of protecting the public from marketing campaigns (i.e., DTCA) that may deliver misleading information.

  20. Rock Magnetic Detection of Two Coercivity Components of Magnetosomes in Lake Ely Sediments

    NASA Astrophysics Data System (ADS)

    Kodama, K. P.; Chen, A.; Egli, R.; Vavrek, J.

    2007-12-01

    The modeling of IRM acquisition curves has become an important tool used by environmental magnetists to characterize a sample's magnetic mineralogy. We have applied IRM modeling to lake sediments from Lake Ely, a small, post-glacial lake located in northeastern Pennsylvania. The lake is unique in having a strong sedimentary magnetization dominated by the magnetosomes produced by magnetotactic bacteria. Measurements of Fe, S, and O2 at different depths in the lake's water column, as well as the magnetization of material filtered from the water, indicate that magnetotactic bacteria live in the water column at the oxic-anoxic interface. Magnetic measurements and TEM observations of lake sediments and material caught in a sediment trap indicate that magnetosomes are the major constituent of the magnetic minerals in the lake sediments. IRM modeling shows two separate coercivity components at about 30 mT and 60 mT that are consistent with Egli's (2004) observations of BS (biogenic soft) and BH (biogenic hard) coercivity components for magnetosomes in lake sediments. However, the peaks are poorly determined because only 6-7 data points constrain the 0-100 mT part of the IRM coercivity spectrum. We used pARMs (97 μT DC field) applied in 5 mT alternating field steps between 0 and 100 mT to better resolve the BH and BS coercivity peaks. pARM spectra collected from lake sediment samples reveal one strong coercivity peak at approximately 30 mT in the 0-100 mT range. A second higher coercivity peak at about 80 mT is weakly evident in some samples. Alternating field demagnetization in 104 steps of an ARM applied to one sample also suggests the presence of two coercivity peaks but at 20 and 40 mT. First order reversal curves (FORCs) measured at the Institute for Rock Magnetism show that the magnetic grains behave as non-interacting single domain grains, implying that the magnetosome chains are relatively far apart and probably still intact. The FORC diagrams also show a large

  1. Nuclear Science and Applications with the Next Generation of High-Power Lasers and Brilliant Low-Energy Gamma Beams at ELI-NP

    NASA Astrophysics Data System (ADS)

    Gales, S.; ELI-NP Team

    2015-10-01

    The development of high power lasers and the combination of such novel devices with accelerator technology has enlarged the science reach of many research fields, in particular High Energy, Nuclear and Astrophysics as well as societal applications in Material Science, Nuclear Energy and Medicine. The European Strategic Forum for Research Infrastructures (ESFRI) has selected a proposal based on these new premises called "ELI" for Extreme Light Infrastructure. ELI will be built as a network of three complementary pillars at the frontier of laser technologies. The ELI-NP pillar (NP for Nuclear Physics) is under construction near Bucharest (Romania) and will develop a scientific program using two 10 PW class lasers and a Back Compton Scattering High Brilliance and Intense Low Energy Gamma Beam, a marriage of Laser and Accelerator technology at the frontier of knowledge. In the present paper, the technical and scientific status of the project as well as the applications of the gamma source will be discussed.

  2. C.T. Jackson's 15 October 1846 letter to J.-B.A.L. Elie de Beaumont: Jackson's thoughts on Ether Day's Eve?

    PubMed

    Bause, George S; Sim, Patrick P

    2011-01-01

    As did the previous letter on 30 November 1845 from Charles T. Jackson to J.-B.A.L. Elie de Beaumont, this 15 October 1846 missive underscores the cordial professional relationship between the two geologists. Remarkably, in this "Ether Day's Eve" letter, Jackson never reveals whether he had any clue that W.T.G. Morton would be publicly demonstrating ether anesthesia for surgery the next morning. More importantly, since Elie de Beaumont would play a future pivotal role in assigning initial credit for "discovering anesthesia" to his geological colleague Jackson, rather than to Morton, letters such as these from November of 1845 and October of 1846 can only raise more questions about the impartiality of Elie de Beaumont.

  3. High-Cycle Fatigue Properties of Notched Specimens for Ti-6Al-4V ELI Alloy at Cryogenic Temperatures

    SciTech Connect

    Yuri, T.; Ono, Y.; Ogata, T.

    2006-03-31

    The notch effects on the high-cycle fatigue properties of Ti-6Al-4V ELI alloy have been investigated at cryogenic temperatures. Smooth and notched specimens with the Kt=1.5, Kt=2 and Kt=3 were prepared. High-cycle fatigue tests were carried out at 4, 77 and 293 K. One million cycles fatigue strength (FS) of smooth specimen was increased with a decrease of the test temperature. Although the FS of each notched specimen at 4 K were lower than those of 77 K. Fatigue crack initiation sites of the smooth, the Kt=1.5 and the Kt=2 notched specimens at 4 K were facets in the specimen interior (internal type fracture) and those of the Kt=3 notched specimens were at the notch root (surface type fracture). The size of individual facets comprising the internal fatigue crack initiation sites correspond to almost the {alpha}-grain size. Therefore, improvement of the fatigue strength of the notched specimens for Ti-6Al-4V ELI alloy which show internal type fracture at cryogenic temperatures requires attaining a smaller area size by grain refining.

  4. High-Cycle Fatigue Properties of Notched Specimens for Ti-6Al-4V ELI Alloy at Cryogenic Temperatures

    NASA Astrophysics Data System (ADS)

    Yuri, T.; Ono, Y.; Ogata, T.

    2006-03-01

    The notch effects on the high-cycle fatigue properties of Ti-6Al-4V ELI alloy have been investigated at cryogenic temperatures. Smooth and notched specimens with the Kt=1.5, Kt=2 and Kt=3 were prepared. High-cycle fatigue tests were carried out at 4, 77 and 293 K. One million cycles fatigue strength (FS) of smooth specimen was increased with a decrease of the test temperature. Although the FS of each notched specimen at 4 K were lower than those of 77 K. Fatigue crack initiation sites of the smooth, the Kt=1.5 and the Kt=2 notched specimens at 4 K were facets in the specimen interior (internal type fracture) and those of the Kt=3 notched specimens were at the notch root (surface type fracture). The size of individual facets comprising the internal fatigue crack initiation sites correspond to almost the α-grain size. Therefore, improvement of the fatigue strength of the notched specimens for Ti-6Al-4V ELI alloy which show internal type fracture at cryogenic temperatures requires attaining a smaller area size by grain refining.

  5. Monte Carlo simulation of a collimation system for low-energy beamline of ELI-NP Gamma Beam System

    NASA Astrophysics Data System (ADS)

    Cardarelli, P.; Gambaccini, M.; Marziani, M.; Bagli, E.; Petrillo, V.; Bacci, A.; Curatolo, C.; Drebot, I.; Vaccarezza, C.

    2015-07-01

    ELI-nuclear physics (NP) Gamma Beam System (GBS) is an intense and monochromatic gamma beam source based on inverse Compton interaction, currently being built in Bucharest, Romania. The gamma beam produced, with energy ranging from 0.2 to 20 MeV, energy bandwidth 0.5% and flux of about 108photons/s, will be devoted to investigate a broad range of applications such as nuclear physics, astrophysics, material science and life sciences. The radiation produced by an inverse Compton interaction is not intrinsically monochromatic. In fact, the energy of the photons produced is related to the emission angle, therefore the energy bandwidth can be modified adjusting the collimation of the gamma beam. In order to define the optimal layout and evaluate the performance of a collimation system for the ELI-NP-GBS low-energy beamline (0.2-3.5 MeV), a detailed Monte Carlo simulation activity has been carried out. The simulation, using Geant4 and MCNPX codes, included the transport of the gamma beam from the interaction point to the experimental area passing through vacuum pipes, vacuum chambers, collimation system and relative shielding. The effectiveness of the collimation system, in obtaining the required energy distribution and avoiding the contamination due to secondary radiation production, was evaluated. Also, the background radiation generated by collimation and the shielding layout have been studied.

  6. Medical research and multidisciplinary applications with laser-accelerated beams: the ELIMED netwotk at ELI-Beamlines

    NASA Astrophysics Data System (ADS)

    Tramontana, A.; Anzalone, A.; Candiano, G.; Carpinelli, M.; Cirrone, G. A. P.; Cuttone, G.; Korn, G.; Licciardello, T.; Maggiore, M.; Manti, L.; Margarone, D.; Musumarra, A.; Perozziello, F.; Pisciotta, P.; Raffaele, L.; Romano, F.; Romano, F. P.; Stancampiano, C.; Schillaci, F.; Scuderi, V.; Torrisi, L.; Tudisco, S.

    2014-04-01

    Laser accelerated proton beams represent nowadays an attractive alternative to the conventional ones and they have been proposed in different research fields. In particular, the interest has been focused in the possibility of replacing conventional accelerating machines with laser-based accelerators in order to develop a new concept of hadrontherapy facilities, which could result more compact and less expensive. With this background the ELIMED (ELIMED: ELI-Beamlines MEDical applications) research project has been launched by LNS-INFN researchers (Laboratori Nazionali del Sud-Istituto Nazionale di Fisica Nucleare, Catania, IT) and ASCR-FZU researchers (Academy of Sciences of the Czech Republic-Fyzikální ústar, Prague, Cz), within the pan-European ELI-Beamlines facility framework. Its main purposes are the demonstration of future applications in hadrontherapy of optically accelerated protons and the realization of a laser-accelerated ion transport beamline for multidisciplinary applications. Several challenges, starting from laser-target interaction and beam transport development, up to dosimetric and radiobiological issues, need to be overcome in order to reach the final goals. The design and the realization of a preliminary beam handling and dosimetric system and of an advanced spectrometer for high energy (multi-MeV) laser-accelerated ion beams will be shortly presented in this work.

  7. Effect of Test Frequency on Fatigue Crack Growth Rates of Ti-6Al-4V ELI Alloy at Cryogenic Temperature

    SciTech Connect

    Yuri, T.; Ono, Y.; Ogata, T.

    2006-03-31

    In order to clarify the effect of test frequency on the fatigue crack growth rates (da/dN) of Ti-6Al-4V ELI alloy have been investigated at cryogenic temperature. The fatigue crack growth tests were conducted using the test frequencies of 5 and 20 Hz, respectively. At 4 K, the effects of the test frequencies on the fatigue crack growth rates of Ti-6Al-4V ELI alloy were not clear or significant. The fatigue crack growth rates in the low propagation rate region at 4 K were smaller than those at 293 K. On the other hand, those in the high propagation rate region at 4 K were bigger than those at 293 K. The former is considered that the crack closure level was higher as compared to that at 293 K and the latter is due to the difference values of the fracture toughness at 4 and 293 K, respectively. The fracture surfaces of compact tension (CT) specimens in the high propagation rate regions at each test temperature revealed the striations, and furthermore accompanied with the flute fracture surface at 4 K. On the other hand, those of CT specimens in the low propagation rate region at 4 K were found facet-like fracture surfaces corresponding with almost the {alpha}-grain size.

  8. Measuring GAMMA 10 end-loss ions with an ELIS (end-loss-ion spectrometers) from TMX-U

    SciTech Connect

    Foote, J.H.

    1987-09-03

    The author spent the period from March 22 to July 10, 1987, at the GAMMA 10 tandem-mirror experiment at the University of Tsukuba in Tsukuba, Japan. The purpose of this extended trip was to install on GAMMA 10 one of the end-loss-ion spectrometers (ELIS) used on TMX-U (Tandem Mirror Experiment-Upgrade) at LLNL and to make plasma measurements there with this diagnostic instrument. This report discusses the considerable planning and preparations that preceded the trip, the actual experience with the ELIS equipment at GAMMA 10, data and results obtained while the author was there, GAMMA 10 experimental procedures, the scientific and technical support during the stay, and some final comments and suggestions concerning an international exchange such as this one. The data acquired on GAMMA 10 while there, along with earlier data, present an encouraging picture of a plasma in a thermal-barrier mode in a tandem-mirror, magnetic-fusion machine. 6 refs.

  9. The nuclear resonance scattering calibration technique for the EuroGammaS gamma characterisation system at ELI-NP-GBS

    NASA Astrophysics Data System (ADS)

    Pellegriti, M. G.; Albergo, S.; Adriani, O.; Andreotti, M.; Berto, D.; Borgheresi, R.; Cappello, G.; Cardarelli, P.; Consoli, E.; Di Domenico, G.; Evangelisti, F.; Gambaccini, M.; Graziani, G.; Lenzi, M.; Marziani, M.; Palumbo, L.; Passaleva, G.; Paternò, G.; Serban, A.; Squerzanti, S.; Starodubtsev, O.; Tricomi, A.; Variola, A.; Veltri, M.; Zerbo, B.

    2017-03-01

    A Gamma Beam System (GBS), designed by the EuroGammaS collaboration, will be implemented for the ELI-NP facility in Magurele, Romania. The facility will deliver an intense gamma beam, obtained by collimatio of the emerging radiation from inverse Compton interaction. Gamma beam energy range will span from 0.2 up to 19.5 MeV with unprecedented performances in terms of brilliance, photon flux and energy bandwidth. For the characterisation of the gamma beam during the commissioning and normal operation, a full detection system has been designed to measure energy spectrum, beam intensity, space and time profiles. The gamma-beam characterisation system consists of four elements: a Compton spectrometer, to measure and monitor the photon energy spectrum, in particular the energy bandwidth; a sampling calorimeter, for a fast combined measurement of the beam average energy and its intensity; a nuclear resonant scattering spectrometer, for absolute beam energy calibration and inter-calibration of the other detector elements; and finally a beam profile imager to be used for alignment and diagnostics purposes. In this paper, a general overview of the ELI-NP gamma characterisation system will be given and the NRSS system will be in particular discussed.

  10. Selected Water- and Sediment-Quality, Aquatic Biology, and Mine-Waste Data from the Ely Copper Mine Superfund Site, Vershire, VT, 1998-2007

    USGS Publications Warehouse

    Argue, Denise M.; Kiah, Richard G.; Piatak, Nadine M.; Seal, Robert R., II; Hammarstrom, Jane M.; Hathaway, Edward; Coles, James F.

    2008-01-01

    The data contained in this report are a compilation of selected water- and sediment-quality, aquatic biology, and mine-waste data collected at the Ely Copper Mine Superfund site in Vershire, VT, from August 1998 through May 2007. The Ely Copper Mine Superfund site is in eastern, central Vermont (fig. 1) within the Vermont Copper Belt (Hammarstrom and others, 2001). The Ely Copper Mine site was placed on the U.S. Environmental Protection Agency (USEPA) National Priorities List in 2001. Previous investigations conducted at the site documented that the mine is contributing metals and highly acidic waters to local streams (Hammarstrom and others, 2001; Holmes and others, 2002; Piatak and others, 2003, 2004, and 2006). The U.S. Geological Survey (USGS), in cooperation with the USEPA, compiled selected data from previous investigations into uniform datasets that will be used to help characterize the extent of contamination at the mine. The data may be used to determine the magnitude of biological impacts from the contamination and in the development of remediation activities. This report contains analytical data for samples collected from 98 stream locations, 6 pond locations, 21 surface-water seeps, and 29 mine-waste locations. The 98 stream locations are within 3 streams and their tributaries. Ely Brook flows directly through the Ely Copper Mine then into Schoolhouse Brook (fig. 2), which joins the Ompompanoosuc River (fig. 1). The six pond locations are along Ely Brook Tributary 2 (fig. 2). The surface-water seeps and mine-waste locations are near the headwaters of Ely Brook (fig. 2 and fig. 3). The datasets 'Site_Directory' and 'Coordinates' contain specific information about each of the sample locations including stream name, number of meters from the mouth of stream, geographic coordinates, types of samples collected (matrix of sample), and the figure on which the sample location is depicted. Data have been collected at the Ely Copper Mine Superfund site by the

  11. High-cycle fatigue behavior of Ti-5Al-2.5Sn ELI alloy forging at low temperatures

    NASA Astrophysics Data System (ADS)

    Ono, Yoshinori; Yuri, Tetsumi; Ogata, Toshio; Demura, Masahiko; Matsuoka, Saburo; Sunakawa, Hideo

    2014-01-01

    High-cycle fatigue properties of Ti-5Al-2.5Sn Extra Low Interstitial (ELI) alloy forging were investigated at low temperatures. The high-cycle fatigue strength at low temperatures of this alloy was relatively low compared with that at ambient temperature. The crystallographic orientation of a facet formed at a fatigue crack initiation site was determined by electron backscatter diffraction (EBSD) method in scanning electron microscope (SEM) to understand the fatigue crack initiation mechanism and discuss on the low fatigue strength at low temperature. Furthermore, in terms of the practical use of this alloy, the effect of the stress ratio (or mean stress) on the high-cycle fatigue properties was evaluated using the modified Goodman diagram.

  12. Future laser-accelerated proton beams at ELI-Beamlines as potential source of positron emitters for PET

    NASA Astrophysics Data System (ADS)

    Amato, E.; Italiano, A.; Margarone, D.; Pagano, B.; Baldari, S.; Korn, G.

    2016-04-01

    The development of novel compact PET radionuclide production systems is of great interest to promote the diffusion of PET diagnostics, especially in view of the continuous development of novel, fast and efficient, radiopharmaceutical methods of labeling. We studied the feasibility to produce clinically-relevant amounts of PET isotopes by means of laser-accelerated proton sources expected at the ELI-Beamlines facility where a PW, 30 fs, 10 Hz laser system will be available. The production yields of several positron emitters were calculated through the TALYS software, by taking into account three possible scenarios of broad proton spectra expected, with maximum energies ranging from about 8 MeV to 100 MeV. With the hypothesized proton fluencies, clinically-relevant amounts of radionuclides can be obtained, suitable to prepare single doses of radiopharmaceuticals exploiting modern fast and efficient labeling systems.

  13. Laser Assisted Milling of Ti-6Al-4V ELI with the Analysis of Surface Integrity and its Economics

    NASA Astrophysics Data System (ADS)

    Hedberg, Gary K.; Shin, Yung C.

    2015-09-01

    This study presents the experimental evaluation of laser assisted milling (LAML) of Ti-6AL-4V ELI (Ti-64), which is used in the orthopedic industry, by using localized preheating of the workpiece via laser irradiation. Improvements to the machinability of this material with LAML are assessed while considering the surface integrity. Suitable laser heating conditions as well as machining conditions are determined based on temperature prediction modeling. Machinability improvements are shown in terms of tool wear, material removal rates and cutting force reduction. Systematic characterization of samples is shown to demonstrate that the machined sub-surfaces are not adversely affected during LAML by precisely controlling laser heating, via hardness measurements, scanning electron microscopy (SEM) for microstructure analysis, and X-ray diffraction (XRD) for residual stresses. An economic analysis shows that LAML provides the cost reduction over conventional machining.

  14. Investigation of the d(γ,n)p reaction for gamma beam monitoring at ELI-NP

    NASA Astrophysics Data System (ADS)

    Matei, C.; Mueller, J. M.; Sikora, M. H.; Suliman, G.; Ur, C. A.; Weller, H. R.

    2016-05-01

    The Extreme Light Infrastructure - Nuclear Physics facility will deliver brilliant gamma beams with high spectral density and a high degree of polarization starting in 2018 in Bucharest-Magurele, Romania. Several monitoring instruments are proposed for measuring the spectral, temporal, and spatial characteristics of the gamma beam. The d(γ,n)p reaction has been investigated for its use in determining the gamma beam parameters in a series of measurements carried out at the High Intensity Gamma Source, Durham, U.S.A.. Measurements of the emitted neutrons have been performed using liquid scintillator and 6Li-glass neutron detectors at several incident gamma energies between 2.5 to 20 MeV . The experimental results presented in this paper have shown that an instrument based on the d(γ,n)p reaction can be used to monitor the intensity and polarization of the gamma beam to be produced at ELI-NP.

  15. High-cycle fatigue behavior of Ti-5Al-2.5Sn ELI alloy forging at low temperatures

    SciTech Connect

    Ono, Yoshinori; Yuri, Tetsumi; Ogata, Toshio; Demura, Masahiko; Matsuoka, Saburo; Sunakawa, Hideo

    2014-01-27

    High-cycle fatigue properties of Ti-5Al-2.5Sn Extra Low Interstitial (ELI) alloy forging were investigated at low temperatures. The high-cycle fatigue strength at low temperatures of this alloy was relatively low compared with that at ambient temperature. The crystallographic orientation of a facet formed at a fatigue crack initiation site was determined by electron backscatter diffraction (EBSD) method in scanning electron microscope (SEM) to understand the fatigue crack initiation mechanism and discuss on the low fatigue strength at low temperature. Furthermore, in terms of the practical use of this alloy, the effect of the stress ratio (or mean stress) on the high-cycle fatigue properties was evaluated using the modified Goodman diagram.

  16. Complex subvolcanic magma plumbing system of an alkali basaltic maar-diatreme volcano (Elie Ness, Fife, Scotland)

    NASA Astrophysics Data System (ADS)

    Gernon, T. M.; Upton, B. G. J.; Ugra, R.; Yücel, C.; Taylor, R. N.; Elliott, H.

    2016-11-01

    Alkali basaltic diatremes such as Elie Ness (Fife, Scotland) expose a range of volcanic lithofacies that points to a complex, multi-stage emplacement history. Here, basanites contain phenocrysts including pyrope garnet and sub-calcic augites from depths of 60 km. Volcanic rocks from all units, pyroclastic and hypabyssal, are characterised by rare earth element (REE) patterns that show continuous enrichment from heavy REE (HREE) to light REE (LREE), and high Zr/Y that are consistent with retention of garnet in the mantle source during melting of peridotite in a garnet lherzolite facies. Erupted garnets are euhedral and unresorbed, signifying rapid ascent through the lithosphere. The magmas also transported abundant pyroxenitic clasts, cognate with the basanite host, from shallower depths ( 35-40 km). These clasts exhibit wide variation in texture, mode and mineralogy, consistent with growth from a range of compositionally diverse melts. Further, clinopyroxene phenocrysts from both the hypabyssal and pyroclastic units exhibit a very wide compositional range, indicative of polybaric fractionation and magma mixing. This is attributed to stalling of earlier magmas in the lower crust - principally from 22 to 28 km - as indicated by pyroxene thermobarometry. Many clinopyroxenes display chemical zoning profiles, occasionally with mantles and rims of higher magnesium number (Mg#) suggesting the magmas were mobilised by juvenile basanite magma. The tuffs also contain alkali feldspar megacrysts together with Fe-clinopyroxene, zircon and related salic xenoliths, of the 'anorthoclasite suite' - inferred to have crystallised at upper mantle to lower crustal depths from salic magma in advance of the mafic host magmas. Despite evidence for entrainment of heterogeneous crystal mushes, the rapidly ascending melts experienced negligible crustal contamination. The complex association of phenocrysts, megacrysts and autoliths at Elie Ness indicates thorough mixing in a dynamic system

  17. Complex modes of bonding: NCI/ELI-D vs. DORI surface analyses of hapticities and hydrogen-hydrogen contacts in zincocene related compounds

    NASA Astrophysics Data System (ADS)

    Mebs, Stefan

    2016-05-01

    Atoms-in-molecules (AIM) topology is prone to wrong/ambiguous bond assignments (lacking bond critical points) in areas of low electron densities (ED), e.g. for hydrogen-hydrogen contacts, and flat density gradients, e.g. for metal-ring contacts (hapticities), both in experimental and computed ED. Within this study, two ED-derived bonding indicators are applied to a set of zincocene related compounds: non-covalent interactions (NCI) surfaces are combined with electron localizability indicator (ELI-D) surfaces and compared to density overlap regions indicator (DORI) surfaces. Both methods (NCI/ELI-D, DORI) result in spatial deconvolution of covalent and non-covalent interactions and unravel weak interactions not observed in the AIM topology.

  18. [Clinical significance of antiphospholipid antibody measured by EliA anticardiolipin antibodies and anti-β2Glycoprotein I antibodies in antiphospholipid syndrome].

    PubMed

    Fujieda, Yuichiro; Shida, Haruki; Oku, Kenji; Bohgaki, Toshiyuki; Amengual, Olga; Horita, Tetsuya; Yasuda, Shinsuke; Atsumi, Tatsuya

    2014-01-01

    Anticardiolipin antibodies (aCL-IgG/IgM) and anti-β2-glycoprotein I antibodies (aβ2GPI-IgG/IgM) are laboratory tests included in the current classification criteria for definite antiphospholipid syndrome (APS). However, not all of these assays have been commercially available in Japan. We investigated the efficacy of aCL-IgG/IgM and aβ2GPI-IgG/IgM assays using fluorescence enzyme immunoassay (Phadia:EliA(TM)) for the diagnosis of APS in Japan. This study comprised 229 sera from patients (100 with APS and 129 without APS). The diagnosis of APS was made according to Sydney revised Sapporo criteria. EliA(TM)Cardiolipin and EliA(TM)β2-Glycoprotein (Phadia AB. Uppsala Sweden) were used to detect aCL IgG/M and aβ2GPI IgG/M, respectively. Sensitivity, specificity and area under the receiver operating characteristic curve (AUC) were as follows; aCL-IgG (45%, 94%, 0.80), aCL-IgM (20%, 94%, 0.54), aβ2GPI-IgG (33%, 98%, 0.88) and aβ2GPI-IgM (16%, 99%, 0.64) respectively. aCL-IgM, aβ2GPI-IgG or aβ2GPI-IgM were detected in 10 patients (18%) with aCL-IgG negative. The use of Phadia:EliA(TM)antiphospholipid antibodies assays improve the diagnostic yield of thrombotic risk in APS patients.

  19. Nuclear Science and Applications with the Next Generation of High-Power Lasers and Brilliant Low-Energy Gamma Beams at ELI-NP

    NASA Astrophysics Data System (ADS)

    Gales, S.

    The development of high power lasers and the combination of such novel devices with accelerator technology has enlarged the science reach of many research fields, in particular Particle and Nuclear Physics, Astrophysics as well as societal applications in Material Science, Nuclear Energy and Medicine. The European Strategic Forum for Research Infrastructures (ESFRI) has selected a proposal based on these new premises called "ELI" for Extreme Light Infrastructure. ELI will be built as a network of three complementary pillars at the frontier of laser technologies. The ELI-NP pillar (NP for Nuclear Physics) is under construction near Bucharest (Romania) and will develop a scientific program using two 10 PW lasers and a Compton back-scattering high-brilliance and intense low-energy gamma beam, a marriage of laser and accelerator technology at the frontier of knowledge. In the present paper, the technical description of the facility, the present status of the project as well as the science, applications and future perspectives will be discussed.

  20. Nuclear Science and Applications with the Next Generation of High-Power Lasers and Brilliant Low-Energy Gamma Beams at ELI-NP

    NASA Astrophysics Data System (ADS)

    Gales, S.

    2015-11-01

    The development of high-power lasers and the combination of such novel devices with accelerator technology has enlarged the science reach of many research fields, in particular high-energy nuclear physics and astrophysics, as well as societal applications in material science, nuclear energy and medicine. The European Strategic Forum for Research Infrastructures (ESFRI) has selected a proposal based on these new premises called "ELI" for Extreme Light Infrastructure. ELI will be built as a network of three complementary pillars at the frontier of laser technologies. The ELI-NP pillar (NP for nuclear physics) is under construction near Bucharest (Romania) and will develop a scientific program using two 10-PW lasers and a Compton back-scattering high-brilliance and intense low-energy gamma beam, a marriage of laser and accelerator technology at the frontier of knowledge. In the present paper, the technical description of the facility, the present status of the project as well as the science, applications and future perspectives will be discussed.

  1. High and low energy gamma beam dump designs for the gamma beam delivery system at ELI-NP

    NASA Astrophysics Data System (ADS)

    Yasin, Zafar; Matei, Catalin; Ur, Calin A.; Mitu, Iani-Octavian; Udup, Emil; Petcu, Cristian

    2016-03-01

    The Extreme Light Infrastructure - Nuclear Physics (ELI-NP) is under construction in Magurele, Bucharest, Romania. The facility will use two 10 PW lasers and a high intensity, narrow bandwidth gamma beam for stand-alone and combined laser-gamma experiments. The accurate estimation of particle doses and their restriction within the limits for both personel and general public is very important in the design phase of any nuclear facility. In the present work, Monte Carlo simulations are performed using FLUKA and MCNPX to design 19.4 and 4 MeV gamma beam dumps along with shielding of experimental areas. Dose rate contour plots from both FLUKA and MCNPX along with numerical values of doses in experimental area E8 of the facility are performed. The calculated doses are within the permissible limits. Furthermore, a reasonable agreement between both codes enhances our confidence in using one or both of them for future calculations in beam dump designs, radiation shielding, radioactive inventory, and other calculations releated to radiation protection. Residual dose rates and residual activity calculations are also performed for high-energy beam dump and their effect is negligible in comparison to contributions from prompt radiation.

  2. Source of slow polarized positrons using the brilliant gamma beam at ELI-NP. Converter design and simulations

    NASA Astrophysics Data System (ADS)

    Djourelov, Nikolay; Oprisa, Andreea; Leca, Victor

    2016-01-01

    Simulations of slow positron (es+) source based on interaction of a circularly polarized gamma beam with a W converter were performed. The aim of the study was to propose a converter geometry and to determine the expected slow positron beam intensity and its spot size, and the degree of positron spin polarization, as well. The Monte Carlo simulations by means of GEANT4 were used to estimate the fast positron production and the moderation efficiency of the converter working as a self-moderator, as well. Finite element analysis by means of COMSOL Multiphysics was applied to calculate the fraction of extracted moderated positrons from the converter cells and the quality of the beam formation by focusing. Using the low energy (<3.5 MeV) gamma beam at ELI-NP with intensity of 2.4×1010γ/s the production of a slow positron beam with intensity of 1-2×106 es+/s is predicted. For the optimized converter geometry and in case of 100% circular polarization of the gammas the degree of spin polarization of the slow positron beam is expected to be 33%.

  3. Gene expression of human osteoblasts cells on chemically treated surfaces of Ti-6Al-4V-ELI.

    PubMed

    Oliveira, D P; Palmieri, A; Carinci, F; Bolfarini, C

    2015-06-01

    Surface modifications of titanium alloys are useful methods to enhance the biological stability of intraosseous implants and to promote a well succeeded osseointegration in the early stages of implantation. This work aims to investigate the influence of chemically modified surfaces of Ti-6Al-4V-ELI (extra-low interstitial) on the gene expression of human osteoblastic (HOb) cells. The surface treatments by acid etching or acid etching plus alkaline treatment were carried out to modify the topography, effective area, contact angle and chemical composition of the samples. The surface morphology was investigated using: scanning electron microscopy (SEM) and confocal laser-scanning microscope (CLSM). Roughness measurements and effective surface area were obtained using the CLSM. Surface composition was analysed by energy dispersive X-ray spectroscopy (EDX) and by X-Ray Diffraction (XRD). The expression levels of some bone related genes (ALPL, COL1A1, COL3A1, SPP1, RUNX2, and SPARC) were analysed using real-time Reverse Transcription Polymerase Chain Reaction (real-time RT-PCR). The results showed that all the chemical modifications studied in this work influenced the surface morphology, wettability, roughness, effective area and gene expression of human osteoblasts. Acid phosphoric combined to alkaline treatment presented a more accelerated gene expression after 7days while the only phosphoric etching or chloride etching combined to alkaline treatment presented more effective responses after 15days.

  4. Front end for ELI-Beamlines' 100J cryogenically cooled Yb:YAG multi-slab amplifier with temporal pulse shaping capability

    NASA Astrophysics Data System (ADS)

    Green, Jonathan T.; Naylon, Jack A.; Mazanec, Tomáś; Horáček, Martin; Bakule, Pavel; Rus, Bedřich

    2014-02-01

    We report on the progress of the front end development for a 100 J, 1030 nm amplifier at ELI-Beamlines and discuss requirements for and features of the front end. A particular emphasis is placed on the use of a fiber-based nanosecond pulse generator to produce arbitrarily shaped, stable pulses. Disadvantages of using such a fiber-based seed, such as a wandering baseline, are discussed and solutions are presented. A home-built RF harmonic synthesizer is shown to be capable of controlled sub-nanosecond shaping of optical pulses.

  5. [ELIE METCHNIKOFF--THE FOUNDER OF LONGEVITY SCIENCE AND A FOUNDER OF MODERN MEDICINE: IN HONOR OF THE 170TH ANNIVERSARY].

    PubMed

    Stambler, I S

    2015-01-01

    The years 2015-2016 mark a double anniversary--the 170th anniversary of birth and the 100th anni- versary of death--of one of the greatest Russian scientists, a person that may be considered a founding figure of modern immunology, aging and longevity science--Elie Metchnikoff (May 15, 1845-July 15, 1916). At this time of the rapid aging of the world population and the rapid development of technologies that may ameliorate degenerative aging processes, Metchnikoff's pioneering contribution to the search for anti-aging and healthspan-extending means needs to be recalled and honored.

  6. Laser-induced damage threshold tests of ultrafast multilayer dielectric coatings in various environmental conditions relevant for operation of ELI beamlines laser systems

    NASA Astrophysics Data System (ADS)

    Ďurák, Michal; Velpula, Praveen Kumar; Kramer, Daniel; Cupal, Josef; Medřík, Tomáš; Hřebíček, Jan; Golasowski, Jiří; Peceli, Davorin; Kozlová, Michaela; Rus, Bedřich

    2017-01-01

    Increasing the laser-induced damage resistance of optical components is one of the major challenges in the development of Peta-watt (PW) class laser systems. The extreme light infrastructure (ELI) beamlines project will provide ultrafast laser systems with peak powers up to 10 PW available every minute and PW class beams at 10 Hz complemented by a 5-TW, 1-kHz beamline. Sustainable performance of PW class laser systems relies on the durability of the employed optical components. As part of an effort to evaluate the damage resistance of components utilized in ELI beamlines systems, damage thresholds of several optical multilayer dielectric coatings were measured with different laser parameters and in different environments. Three coatings were tested with 10 Hz and 1 kHz pulse repetition rates, and the effect of a cleaning treatment on their damage resistance was examined. To explore the damage threshold behavior at different vacuum levels, one coating was subject to tests at various residual gas pressures. No change of damage threshold in a high vacuum with respect to ambient pressure was recorded. The effect of the cleaning treatment was found to be inconsistent, suggesting that development of the optimal cleaning treatment for a given coating requires consideration of its specific properties.

  7. Effect of low temperature on fatigue and fracture properties of Ti-5Al-2.5Sn(ELI) for use in engine components

    NASA Technical Reports Server (NTRS)

    Ryder, J. T.; Witzell, W. E.

    1985-01-01

    Experiments were conducted to evaluate the characteristics of the Ti-5Al-2.5Sn (ELI) alloy used in a fuel pump impeller at cryogenic temperatures. Tension, fracture toughness, and fatigue crack propagation data were collected determining the effect of frequency and load ratio on crack propagation. The results revealed that tensile strength increased significantly at 20 K compared to room temperature and fracture toughness was reduced at cryogenic temperatures. The fatigue crack growth rate was not sensitive to experimental conditions and there were only minimal crack orientation effects. Different frequencies produced no effect. At various temperatures and frequencies a load ratio increase resulted in higher crack growth rates. At low stress intensity levels the fatigue rate for both temperatures was the same; however, at high stress intensity levels the crack growth rate at 20 K increased because of the decrease in fracture toughness. The results correlated well with previous data.

  8. Effect of stress ratio on high-cycle fatigue properties of Ti-6Al-4V ELI alloy forging at low temperature

    NASA Astrophysics Data System (ADS)

    Ono, Yoshinori; Yuri, Tetsumi; Ogata, Toshio; Matsuoka, Saburo; Sunakawa, Hideo

    2014-01-01

    The effect of the stress ratio R (the ratio of minimum stress to maximum stress) on the high-cycle fatigue properties of Ti-6Al-4V extra-low interstitial (ELI) alloy forging was investigated at 293 and 77 K. At 293 K, the fatigue strength at 107 cycles exhibited deviations below the modified Goodman line in the R=0.01 and 0.5 tests. Moreover, at 77 K, larger deviations of the fatigue strength at 107 cycles below the modified Goodman line were confirmed in the same stress ratio conditions. The high-cycle fatigue strength of the present alloy forging exhibit an anomalous mean stress dependency at both temperatures and this dependency becomes remarkable at low temperature.

  9. Fundamental relation between molecular geometry and real-space topology. Combined AIM, ELI-D, and ASF analysis of hapticities and intramolecular hydrogen-hydrogen bonds in zincocene-related compounds.

    PubMed

    Mebs, Stefan; Chilleck, Maren Annika; Meindl, Kathrin; Hübschle, Christian Bertram

    2014-06-19

    Despite numerous advanced and widely distributed bonding theories such as MO, VB, NBO, AIM, and ELF/ELI-D, complex modes of bonding such as M-Cp*((R)) interactions (hapticities) in asymmetrical metallocenes or weak intramolecular interactions (e.g., hydrogen-hydrogen (H···H) bonds) still remain a challenge for these theories in terms of defining whether or not an atom-atom interaction line (a "chemical bond") should be drawn. In this work the intramolecular Zn-C(Cp*(R)) (R = Me, -(CH2)2NMe2, and -(CH2)3NMe2) and H···H connectivity of a systematic set of 12 zincocene-related compounds is analyzed in terms of AIM and ELI-D topology combined with the recently introduced aspherical stockholder fragment (ASF) surfaces. This computational analysis unravels a distinct dependency of the AIM and ELI-D topology against the molecular geometry for both types of interactions, which confirms and extends earlier findings on smaller sets of compounds. According to these results the complete real-space topology including strong, medium, and weak interactions of very large compounds such as proteins may be reliably predicted by sole inspection of accurately determined molecular geometries, which would on the one hand afford new applications (e.g., accurate estimation of numbers, types, and strengths of intra- and intermolecular interactions) and on the other hand have deep implications on the significance of the method.

  10. Geochemical characterization of slags, other mines wastes, and their leachates from the Elizabeth and Ely mines (Vermont), the Ducktown mining district (Tennessee), and the Clayton smelter site (Idaho)

    USGS Publications Warehouse

    Piatak, Nadine M.; Seal, Robert R., II; Hammarstrom, Jane M.; Meier, Allen L.; Briggs, Paul H.

    2003-01-01

    Waste-rock material produced at historic metal mines contains elevated concentrations of potentially toxic trace elements. Two types of mine waste were examined in this study: sintered waste rock and slag. The samples were collected from the Elizabeth and Ely mines in the Vermont copper belt (Besshi-type massive sulfide deposits), from the Copper Basin mining district near Ducktown, Tennessee (Besshi-type massive sulfide deposits), and from the Clayton silver mine in the Bayhorse mining district, Idaho (polymetallic vein and replacement deposits). The data in this report are presented as a compilation with minimal interpretation or discussion. A detailed discussion and interpretation of the slag data are presented in a companion paper. Data collected from sintered waste rock and slag include: (1) bulk rock chemistry, (2) mineralogy, (3) and the distribution of trace elements among phases for the slag samples. In addition, the reactivity of the waste material under surficial conditions was assessed by examining secondary minerals formed on slag and by laboratory leaching tests using deionized water and a synthetic solution approximating precipitation in the eastern United States.

  11. Wear Mechanism of Chemical Vapor Deposition (CVD) Carbide Insert in Orthogonal Cutting Ti-6Al-4V ELI at High Cutting Speed

    SciTech Connect

    Gusri, A. I.; Che Hassan, C. H.; Jaharah, A. G.

    2011-01-17

    The performance of Chemical Vapor Deposition (CVD) carbide insert with ISO designation of CCMT 12 04 04 LF, when turning titanium alloys was investigated. There were four layers of coating materials for this insert i.e.TiN-Al2O3-TiCN-TiN. The insert performance was evaluated based on the insert's edge resistant towards the machining parameters used at high cutting speed range of machining Ti-6Al-4V ELI. Detailed study on the wear mechanism at the cutting edge of CVD carbide tools was carried out at cutting speed of 55-95 m/min, feed rate of 0.15-0.35 mm/rev and depth of cut of 0.10-0.20 mm. Wear mechanisms such as abrasive and adhesive were observed on the flank face. Crater wear due to diffusion was also observed on the rake race. The abrasive wear occurred more at nose radius and the fracture on tool were found at the feed rate of 0.35 mm/rev and the depth of cut of 0.20 mm. The adhesion wear takes place after the removal of the coating or coating delaminating. Therefore, adhesion or welding of titanium alloy onto the flank and rake faces demonstrates a strong bond at the workpiece-tool interface.

  12. Effects of heat treatments on microstructure and properties of Ti-6Al-4V ELI alloy fabricated by electron beam melting (EBM)

    DOE PAGES

    Galarraga, Haize; Warren, Robert J.; Lados, Diana A.; ...

    2017-01-06

    Electron beam melting (EBM) is a metal powder bed fusion additive manufacturing (AM) technology that is used to fabricate three-dimensional near-net-shaped parts directly from computer models. Ti-6Al-4V is the most widely used and studied alloy for this technology and is the focus of this work in its ELI (Extra Low Interstitial) variation. The mechanisms of microstructure formation, evolution, and its subsequent influence on mechanical properties of the alloy in as-fabricated condition have been documented by various researchers. In the present work, the thermal history resulting in the formation of the as-fabricated microstructure was analyzed and studied by a thermal simulation.more » Subsequently different heat treatments were performed based on three approaches in order to study the effects of heat treatments on the singular and exclusive microstructure formed during the EBM fabrication process. In the first approach, the effect of cooling rate after the solutionizing process was studied. In the second approach, the variation of α lath thickness during annealing treatment and correlation with mechanical properties was established. In the last approach, several solutionizing and aging experiments were conducted.« less

  13. Study of the production yields of 18F, 11C, 13N and 15O positron emitters from plasma-laser proton sources at ELI-Beamlines for labeling of PET radiopharmaceuticals

    NASA Astrophysics Data System (ADS)

    Amato, Ernesto; Italiano, Antonio; Margarone, Daniele; Pagano, Benedetta; Baldari, Sergio; Korn, Georg

    2016-03-01

    The development of novel compact PET radionuclide production systems is of great interest to promote the diffusion of PET diagnostics, especially in view of the continuous development of microfluidics labeling approaches. We studied the feasibility to produce clinically-relevant amounts of PET isotopes by means of laser-accelerated proton sources such that expected at the ELI-Beamlines facility. 18F, 11C, 13N and 15O production yields were calculated through the TALYS software, by taking into account the broad proton spectra expected. With the hypothesized proton fluencies, clinically-relevant amounts of radionuclides can be obtained, suitable to prepare single doses of 18F-, 11C- and 13N-labeled radiopharmaceuticals exploiting fast and efficient microfluidic labeling systems.

  14. High power femtosecond lasers at ELI-NP

    SciTech Connect

    Dabu, Razvan

    2015-02-24

    Specifications of the high power laser system (HPLS) designed for nuclear physics experiments are presented. Configuration of the 2 × 10 PW femtosecond laser system is described. In order to reach the required laser beam parameters, advanced laser techniques are proposed for the HPLS: parametric amplification and cross-polarized wave generation for the intensity contrast improvement and spectral broadening, acousto-optic programmable filters to compensate for spectral phase dispersion, optical filters for spectrum management, combined methods for transversal laser suppression.

  15. Final EDP Ti: sapphire amplifiers for ELI project

    NASA Astrophysics Data System (ADS)

    Chvykov, Vladimir; Kalashnikov, Mikhail; Osvay, Károly

    2015-05-01

    Recently several ultrahigh intensity Chirped Pulse Amplification (CPA) laser systems have reached petawatt output powers [1, 2] setting the next milestone at tens or even hundreds petawatts for the next three to ten years [3, 4]. These remarkable results were reached when laser amplifiers (opposite to Optical Parametric Amplification (OPA) [5]) were used as final ones and from them Ti:Sapphire crystals supposed to be the working horses as well in the future design of these laser systems. Nevertheless, the main limitation that arises on the path toward ultrahigh output power and intensity is the restriction on the pumping and extraction energy imposed by Transverse Amplified Spontaneous Emission (TASE) [6] and/or transverse parasitic generation (TPG) [7] within the large aperture of the disc-shape amplifier volume.

  16. Shielding assessment of high field (QED) experiments at the ELI-NP 10 PW laser system.

    PubMed

    Popovici, M A; Mitu, I O; Căta-Danil, Gh; Negoit Ă, F; Ivan, C

    2017-03-20

    High field quantum electrodynamics experiments will be conducted in the E6 experimental area of the Extreme Light Infrastructure-Nuclear Physics building. Here electrons and protons will be accelerated up to relativistic energies by multi-petawatt laser beam-target interactions. In this respect, the requirements for radiological safety measures are similar to those associated with the operation of conventional high energy accelerators. The paper presents a FLUKA simulation approach to the shielding assessment of the individual experiments. Updated source terms were used in order to compute ambient dose equivalent rates throughout E6 and neighbouring areas and check the compliance of the results with legal dose constraints. We investigated the effectiveness of an 'all-purpose' beam dump at E6 and the practicality of local muon shielding.

  17. Telling the Tale: Sharing Elie Wiesel's "Night" with Middle School Readers.

    ERIC Educational Resources Information Center

    Hernandez, Alexander A.

    2001-01-01

    Describes how as part of a nine-week unit on tolerance and prejudice, the author's middle school students became immersed in Holocaust literature. Notes that the theme of bearing witness, of never forgetting, which runs through the literature, is the central driving force of work in the classroom. (SG)

  18. Redemptive Family Narratives: Olga Lengyel and the Textuality of the Holocaust: In Memoriam Elie Wiesel.

    PubMed

    Turda, Marius

    2016-01-01

    Memoirs written by Holocaust survivors and (in some cases) their testimonies retain a salience unmatched by other historical sources. This article discusses one such memoir, Olga Lengyel's Five Chimneys, alongside her 1998 testimony, aiming to engage with broader methodological issues relating to the history of the Holocaust, particularly those about memory, narrative and textuality. Through a detailed discussion of certain moments shaping Olga Lengyel's personal experience, both pre-and post-arrival in Auschwitz, the article captures the tensions and contradictions characterizing the harrowing story of one woman's loss of family in the Holocaust.

  19. 75 FR 81190 - Television Broadcasting Services; Vernal and Santaquin, UT, and Ely and Caliente, NV

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-27

    ... Flexibility Act of 1980 do not apply to this proceeding. This document is not subject to the Congressional Review Act. (The Commission, is, therefore, not required to submit a copy of this Order to the Government Accountability Office, pursuant to the Congressional Review Act, see 5 U.S.C. 801(a)(1)(A) since this...

  20. M-X Environmental Technical Report. Alternative Potential Operating Base Locations: Ely.

    DTIC Science & Technology

    1980-12-22

    34 prepared by Walters Engineering of Reno in 1972. I’ Existing Land Use The first general plan for White Pine County was prepared in 1970. It was...Spring, Snake, White River , Jakes, Butte, Long, Newark, Railroad, Cave and Lake hydrologic subunits. For a list of the fishing resources within...affected by increased recreation- al use or by actions affecting water level. Waterfowl areas in Steptoe, Spring, and White River valleys, including

  1. Photo-fusion reactions in a new compact device for ELI

    SciTech Connect

    Moustaizis, S. D.; Auvray, P.; Hora, H.; Lalousis, P.; Larour, J.; Mourou, G.

    2012-07-09

    In the last few years significant progress on technological, experimental and numerical studies on fusion process in high density and high temperature plasmas produced by a high intensity laser pulse interaction with clusters in a high external applied magnetic field, enable us to propose a compact photo-fusion magnetic device for high neutron production. For the purpose of the project a pulsed magnetic field driver with values up to 110 Tesla has been developed which allows increasing the trapping time of the high density plasma in the device and improving the neutron yield. Numerical simulations show that the proposed device is capable of producing up to 10{sup 9}-10{sup 10} neutrons per laser shot with an external magnetic field of 150 Tesla. The proposed device can be used for experiments and numerical code validation concerning different conventional and (or) exotic fusion fuels.

  2. Premium quality 5A1-2.5 Sn ELI titanium production

    NASA Technical Reports Server (NTRS)

    Dessau, P. P.; Harris, C. L.

    1972-01-01

    Preliminary design and reliability analysis conducted on the turbopump for the NERVA 75,000 full flow cycle engine, indicated that the turbopump bearings were the most critical turbopump parts in meeting the 10 hour life at the required turbopump reliability of .99978. The analysis revealed that significant reductions (approximately a factor of 3.25) in bearing loads would be achieved by fabricating the rotating parts from titanium in lieu of A286 or 718. This is basically due to the difference in density of the materials and the resulting mass effect on the location of the first and second stick mode critical speeds. For the selected rotor configuration, the lighter material has a first critical speed at approximately 36,000 rpm, while that of the heavier material has a first critical at approximately 27,000 rpm. As the operating range of the turbopump is from 0 to 30,000 rpm, the heavier material would have a stick mode critical in the operating range.

  3. Using the Literature of Elie Wiesel and Selected Poetry to Teach the Holocaust in the Secondary School History Classroom.

    ERIC Educational Resources Information Center

    Danks, Carol

    1996-01-01

    Maintains that learning about the Holocaust (and other historical incidents) from the literature of survivors provides students with empathy and understanding not found in traditional historical texts. Recommends using this material prior to objective historical study and includes suggestions for teaching. Discusses the use of other Holocaust…

  4. Comment on: ``Chaos in the Showalter-Noyes-Bar-Eli model of the Belousov-Zhabotinskii reaction''

    NASA Astrophysics Data System (ADS)

    Györgyi, László; Field, Richard J.

    1990-08-01

    The recent numerical work of Lindberg et al. convincingly demonstrates that chemical chaos in a continuous flow, stirred tank reactor (CSTR) can be reproduced by a spatially homogeneous, accurate model of the kinetics of the Belousov-Zhabotinskii(BZ) reaction. However, some problems remain. The chaos in this model and two others, one using an accurate model of the chemical kinetics in conjunction with spatial inhomogeneity resulting from the finite CSTR mixing time and the other using a flawed model of the BZ chemical kinetics, results from coupling of two cycles coexisting within the complex dynamic model. The second cycle in the case of the homogeneous models involves a product of the main chemical limit cycle which is present at a high average concentration. In the Lindberg et al. model this product is assumed to be HOBr. It is clear, however, that a large [HOBr] does not accumulate in the real system because of its rapid reaction with Br-. We suggest that while the Lindberg et al. results are clearly important, this process still needs to be accounted for. Furthermore, the rate parameter values used by Lindberg et al. are not those currently thought to be correct, and the chaos disappears if the accurate rate constant values are used. We discuss why this is so. It is further argued that the Lindberg et al. results do not eliminate the possibility that at least part of the experimentally observed CSTR chaos results from effects related to incomplete mixing.

  5. 78 FR 33426 - Eli Lilly and Co.; Withdrawal of Approval of a New Drug Application for ORAFLEX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-04

    ... Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 51, rm. 6250, Silver... postmarketing reports of severe liver toxicity in patients who took ORAFLEX. In a letter dated February 6, 2013... Commissioner of Food and Drugs to the Director, Center for Drug Evaluation and Research, approval of NDA...

  6. Using Movies in EFL Classrooms: A Study Conducted at the English Language Institute (ELI), King Abdul-Aziz University

    ERIC Educational Resources Information Center

    Kabooha, Raniah Hassen

    2016-01-01

    The present study sought to examine the attitudes of Saudi English as a foreign language (EFL) learners as well as teachers towards the integration of English movies in their classes as a tool to develop students' language skills. Fifty female intermediate level students studying English in their Preparatory Year Program (PYP) in the English…

  7. Effects of the microstructure and porosity on properties of Ti-6Al-4V ELI alloy fabricated by electron beam melting (EBM)

    SciTech Connect

    Galarraga, Haize; Lados, Diana A.; Dehoff, Ryan R.; Kirka, Michael M.; Nandwana, Peeyush

    2016-01-01

    Electron Beam Melting (EBM) is a metal powder bed-based Additive Manufacturing (AM) technology that makes possible the fabrication of three dimensional near-net-shaped parts directly from computer models. EBM technology has been in continuously updating, obtaining optimized properties of the processed alloys. Ti-6Al-4V titanium alloy is the most widely used and studied alloy for this technology and is the focus of this work. Several research works have been completed to study the mechanisms of microstructure formation as well as its influence on mechanical properties. However, the relationship is not completely understood, and more systematic research work is necessary in order to attain a better understanding of these features. In this work, samples fabricated at different locations, orientations, and distances from the build platform have been characterized, studying the relationship of these variables with the resulting material intrinsic characteristics and properties (surface topography, microstructure, porosity, micro-hardness and static mechanical properties). This study has revealed that porosity is the main factor controlling mechanical properties relative to the other studied variables. Therefore, in future process developments, decreasing of the porosity should be considered as the primary goal in order to improve mechanical properties.

  8. The effect of post-sintering treatments on the fatigue and biological behavior of Ti-6Al-4V ELI parts made by selective laser melting.

    PubMed

    Benedetti, M; Torresani, E; Leoni, M; Fontanari, V; Bandini, M; Pederzolli, C; Potrich, C

    2017-03-28

    Fatigue resistance and biocompatibility are key parameters for the successful implantation of hard-tissue prostheses, which nowadays are more and more frequently manufactured by selective laser melting (SLM). For this purpose, the present paper is aimed at investigating the effect of post-sintering treatments on the fatigue behavior and biological properties of Ti samples produced by SLM. After the building process, all samples are heat treated to achieve a complete stress relief. The remaining ones are tribofinished with the aim of reducing the surface roughness of the as-sintered condition. Part of the tribofinished samples are then subjected to one of the following post-sintering treatments: (i) shot peening, (ii) hot isostatic pressing (HIP), and (iii) electropolishing. It is found that shot peening and HIP are the most effective treatments to improve the high and the very-high cycle fatigue resistance, respectively. At the same time, they preserve the good biocompatibility ensured by the biomedical Titanium Grade 23.

  9. "I Leave It with the People of the United States to Say": Autobiographical Disruption in the Personal Narratives of Black Hawk and Ely S. Parker

    ERIC Educational Resources Information Center

    Raheja, Michelle H.

    2006-01-01

    This essay demonstrates how American Indian autobiographical narratives work to construct a sense of American Indian subjectivity for competing communities--indigenous and white--by simultaneously promoting and protecting tribal knowledge. Both Black Hawk and Parker understood the power of print circulation in the dominant culture. One of the…

  10. Oxygen transfer from an intramolecularly coordinated diaryltellurium oxide to acetonitrile. Formation and combined AIM and ELI-D analysis of a novel diaryltellurium acetimidate.

    PubMed

    Mallow, Ole; Bolsinger, Jens; Finke, Pamela; Hesse, Malte; Chen, Yu-Sheng; Duthie, Andrew; Grabowsky, Simon; Luger, Peter; Mebs, Stefan; Beckmann, Jens

    2014-08-06

    The reaction of the intramolecularly coordinated diaryltellurium(IV) oxide (8-Me2NC10H6)2TeO with acetonitrile proceeds with oxygen transfer and gives rise to the formation of the novel zwitterionic diaryltelluronium(IV) acetimidate (8-Me2NC10H6)2TeNC(O)CH3 (1) in 57% yield. Hydrolysis of 1 with hydrochloric acid affords acetamide and the previously known diarylhydroxytelluronium(IV) chloride [(8-Me2NC10H6)2Te(OH)]Cl.

  11. Management Information Reporting 2000-01 Data Analysis for Special Education, English as a Second Language (ESL), Early Literacy Initiative (ELI), and Technology Integration Funding (TIF).

    ERIC Educational Resources Information Center

    Alberta Learning, Edmonton.

    This report is intended to stimulate inquiry into the achievement of special groups of students in Alberta schools and model reporting to the public on these students, a traditionally weak area of school board Annual Education Results reports. The data in the report provide provincial level comparisons to data that may be compiled by school…

  12. Effects of the microstructure and porosity on properties of Ti-6Al-4V ELI alloy fabricated by electron beam melting (EBM)

    DOE PAGES

    Galarraga, Haize; Lados, Diana A.; Dehoff, Ryan R.; ...

    2016-01-01

    Electron Beam Melting (EBM) is a metal powder bed-based Additive Manufacturing (AM) technology that makes possible the fabrication of three dimensional near-net-shaped parts directly from computer models. EBM technology has been in continuously updating, obtaining optimized properties of the processed alloys. Ti-6Al-4V titanium alloy is the most widely used and studied alloy for this technology and is the focus of this work. Several research works have been completed to study the mechanisms of microstructure formation as well as its influence on mechanical properties. However, the relationship is not completely understood, and more systematic research work is necessary in order tomore » attain a better understanding of these features. In this work, samples fabricated at different locations, orientations, and distances from the build platform have been characterized, studying the relationship of these variables with the resulting material intrinsic characteristics and properties (surface topography, microstructure, porosity, micro-hardness and static mechanical properties). This study has revealed that porosity is the main factor controlling mechanical properties relative to the other studied variables. Therefore, in future process developments, decreasing of the porosity should be considered as the primary goal in order to improve mechanical properties.« less

  13. Behavior of Ti-5Al-2.5Sn ELI titanium alloy sheet parent and weld metal in the presence of cracks at 20 K

    NASA Technical Reports Server (NTRS)

    Sullivan, T. L.

    1971-01-01

    Through- and surface-cracked specimens of two thicknesses were tested in uniaxial tension. Surface-cracked specimens were generally found to be stronger than through-cracked specimens with the same crack length. Apparent surface-crack fracture toughness calculated using the Anderson modified Irwin equation remained relatively constant for cracks as deep as 90 percent of the sheet thickness. Subcritical growth of surface cracks was investigated. Comparison of chamber and open air welds showed chamber welds to be slightly tougher. Both methods produced welds with toughness that compared favorably with that of the parent metal. Weld efficiencies were above 94 percent.

  14. 47. DETAIL OF ORIGINAL VANE ASSEMBLY AND TWO WHEEL SECTIONS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    47. DETAIL OF ORIGINAL VANE ASSEMBLY AND TWO WHEEL SECTIONS FROM ELI WINDMILLS, THE VANE SHEET BEARING STENCILED PAINTED INSCRIPTION, 'KREGEL WINDMILL CO. ELI NEBRASKA CITY, NEB.' VISIBLE IN THE IMAGE ARE BOTH SIDES OF THE WHEEL SECTIONS, SHOWING THE METHOD OF BLADE MOUNTING FOR ELI WINDMILLS. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  15. Estimating Characteristics of a Maneuvering Reentry Vehicle Observed by Multiple Sensors

    DTIC Science & Technology

    2010-03-01

    eli = 3; % define simulated & actual observations - full RAE sim_z = sim_rae; obs_z...azi = 1; eli = 2; % define simulated & actual observations - only AE sim_z = sim_rae(2...dEl/dX, dY, dZ H( eli ,1) = dEl_base * ((clat*clon*ct - clat*slon*st)*denom_El - (x-sen_eci(1))/denom_El*numer_El) / denom_El^2

  16. Cloning, expression, and characterization of a four-component O-demethylase from human intestinal bacterium Eubacterium limosum ZL-II.

    PubMed

    Chen, Jia-Xing; Deng, Chao-Yin; Zhang, Ying-Tao; Liu, Zhen-Ming; Wang, Ping-Zhang; Liu, Shu-Lin; Qian, Wei; Yang, Dong-Hui

    2016-11-01

    Eubacterium limosum ZL-II was described to convert secoisolariciresinol (SECO) to its demethylating product 4,4'-dihydroxyenterodiol (DHEND) under anoxic conditions. However, the reaction cascade remains unclear. Here, the O-demethylase being responsible for the conversion was identified and characterized. Nine genes encoding two methyltransferase-Is (MT-I), two corrinoid proteins (CP), two methyltransferase-IIs (MT-II), and three activating enzymes (AE) were screened, cloned, and expressed in Escherichia coli. Four of the nine predicted enzymes, including ELI_2003 (MT-I), ELI_2004 (CP), ELI_2005 (MT-II), and ELI_0370 (AE), were confirmed to constitute the O-demethylase in E. limosum ZL-II. The complete O-demethylase (combining the four components) reaction system was reconstructed in vitro. As expected, the demethylating products 3-demethyl-SECO and DHEND were both produced. During the reaction process, ELI_2003 (MT-I) initially catalyzed the transfer of methyl group from SECO to the corrinoid of ELI_2004 ([Co(I)]-CP), yielding demethylating products and [CH3-Co(III)]-CP; then ELI_2005 (MT-II) mediated the transfer of methyl group from [CH3-Co(III)]-CP to tetrahydrofolate, forming methyltetrahydrofolate and [Co(I)]-CP. Due to the low redox potential of [Co(II)]/[Co(I)], [Co(I)]-CP was oxidized to [Co(II)]-CP immediately in vitro, and ELI_0370 (AE) was responsible for catalyzing the reduction of [Co(II)]-CP to its active form [Co(I)]-CP. The active-site residues in ELI_2003, ELI_2005, and ELI_0370 were subsequently determined using molecular modeling combined with site-directed mutagenesis. To our knowledge, this is the first study on the identification and characterization of a four-component O-demethylase from E. limosum ZL-II, which will facilitate the development of method to artificial synthesis of related bioactive chemicals.

  17. Attributes and Characteristics of Exemplary, Leading, and Innovative Career and Technical Education Teacher Preparation Programs.

    ERIC Educational Resources Information Center

    Bruening, Thomas H.; Scanlon, Dennis C.; Hoover, Tracy S.; Hodes, Carol; Shao, Xiaorong; Dhital, Purandhar; Zolotov, Alexandre; Harmon, Hobart

    A study determined critical attributes of the nation's exemplary, leading, or innovative (ELI) career-technical education teacher preparation programs. National experts identified 13 critical attributes of an ELI teacher preparation program. Researchers conducted site visits to 5 institutions--University of Georgia, University of Minnesota, The…

  18. Knowledge-based reusable software synthesis system

    NASA Technical Reports Server (NTRS)

    Donaldson, Cammie

    1989-01-01

    The Eli system, a knowledge-based reusable software synthesis system, is being developed for NASA Langley under a Phase 2 SBIR contract. Named after Eli Whitney, the inventor of interchangeable parts, Eli assists engineers of large-scale software systems in reusing components while they are composing their software specifications or designs. Eli will identify reuse potential, search for components, select component variants, and synthesize components into the developer's specifications. The Eli project began as a Phase 1 SBIR to define a reusable software synthesis methodology that integrates reusabilityinto the top-down development process and to develop an approach for an expert system to promote and accomplish reuse. The objectives of the Eli Phase 2 work are to integrate advanced technologies to automate the development of reusable components within the context of large system developments, to integrate with user development methodologies without significant changes in method or learning of special languages, and to make reuse the easiest operation to perform. Eli will try to address a number of reuse problems including developing software with reusable components, managing reusable components, identifying reusable components, and transitioning reuse technology. Eli is both a library facility for classifying, storing, and retrieving reusable components and a design environment that emphasizes, encourages, and supports reuse.

  19. Syracuse University English Language Institute: Business Communication for Executives

    ERIC Educational Resources Information Center

    de Berly, Geraldine; McGraw, Deborah

    2010-01-01

    The Syracuse University English Language Institute (ELI), housed within University College, has been offering noncredit executive English courses on a contract basis for the past 12 years. Despite its small size and limited resources, the ELI, whose main mission is to prepare international students for academic study, also manages a successful…

  20. On failures in education and public policy

    NASA Astrophysics Data System (ADS)

    Ely, John T. A.

    2007-04-01

    Education of the public and the resulting policies in many matters are grossly inadequate. Included as a small list of four samples of failings in vital matters are: 1. Societal Cohesiveness: A profound change in the school system will yield great benefit for the nation (http://faculty.washington.edu/ely/publicservice.html.). 2. Lack of understanding regarding the coming avian flu pandemic (http://faculty.washington.edu/ely/ElyFluMES.pdf). 3. Severe Hg intoxication from dentistry due to profound multifaceted ignorance (Ely JTA, Mercury induced Alzheimer's disease: accelerating incidence? Bull Environ Contam Toxicol. 2001; 67(6),800-6). 4. The end of the world by global warming due to Christian religion forcing family planning money to be withheld from UN leading to population excess (http://faculty.washington.edu/ely/CO2runaway.html).

  1. Kelp and Eelgrass in Puget Sound

    DTIC Science & Technology

    2007-05-01

    elt er ed to m od er at ely ex po se d ha bi ta ts. Pr os tra te D ict yo ne ur um D . c al ifo rn icu m R up re ch t...at ely sh elt er ed to m od er at ely ex po se d ha bi ta ts. Pr os tra te D ict yo ne ur um D . c al ifo rn icu m R up re ch t. St ra its *U...L in na eu s) La m ou ro ux 1 G re at B en d ar ea , s ou th

  2. 23. Site plan, 1931 Photocopied from Sanborn Map Company, Insurance ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Site plan, 1931 Photocopied from Sanborn Map Company, Insurance Maps of New Haven, v. 5, map no. 540, 1924 updated to 1931. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  3. 21. General view from the southwest, c.1862 Photocopied from an ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. General view from the southwest, c.1862 Photocopied from an advertisement, 'Whitney's Improved Fire-Arms,' Dana Scrapbook v. 61, p. 68, NHCHSL. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  4. 24. Site plan, 1924 Photocopied from Sanborn Map Company, Insurance ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. Site plan, 1924 Photocopied from Sanborn Map Company, Insurance Maps of New Haven, v. 5, map no. 540, 1924 - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  5. Following electron impact excitations of single Os, Pt, Hg, Pb and Po atom L subshells ionization cross section calculations by using Lotz's equation

    NASA Astrophysics Data System (ADS)

    Aydinol, M.; Aydeniz, D.

    2016-03-01

    L shell ionization cross section and Li subshells ionization cross sections of Os, Pt, Hg, Pb, Po atoms calculated. For each atom, ten different electron impacty energy values Eoi used. Calculations carried out by using nonrelativistic Lotz equation in Matlab. Ionization cross section values obtained for Eoi values in the energy range of ELi ≤Eoi≤4ELi for each atom. Starting allmost from Eoi = ELi (i = 1,2,3) values of the each subshell ionization threshold energy, ionization cross section are increasing rapidly with Eoi. For a fixed Eoi = 3. ELi values, while Z increases from Z = 76 to Z = 84, ionization cross section are decrease. These results help to understand some results which obtained from other electron-sigle atom impact studies on σLi subshells.

  6. 75 FR 14091 - Final Flood Elevation Determinations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-24

    ...-1035 Big Creek South Ely Street......... + 713 City of Bertram. Big Creek Road + 719 Cedar Lake Entire.... Mean Sea Level, rounded to the nearest 0.1 meter. ADDRESSES City of Bertram Maps are available...

  7. 75 FR 7291 - Northeastern Great Basin Resource Advisory Council Meetings, Nevada

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-18

    ... N. Industrial Way, Ely, Nevada. Approximate meeting times are 8 a.m. to 4 p.m. However, meetings..., energy, and sustainable development Managers' reports of field office activities will be given at...

  8. Deep Space Atomic Clock Ticks Toward Success

    NASA Video Gallery

    Dr. Todd Ely, principal investigator for NASA's Deep Space Atomic Clock at the Jet Propulsion Laboratory in Pasadena, Calif., spotlights the paradigm-busting innovations now in development to revol...

  9. 78 FR 20680 - Privacy Act of 1974; Department of Homeland Security/U.S. Citizenship and Immigration Services...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-05

    ... temporary data in USCIS ELIS. Temporary data includes draft account data provided by first-time Applicants... Identification Number; Travel History; Professional Accreditation Information; Tax Records; Marriage Certificates... Information (e.g., vaccinations, referrals, communicable disease, physical or mental disorder,...

  10. 19. The 1860 armory building, c.1930 Photocopied from a film ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. The 1860 armory building, c.1930 Photocopied from a film negative, NHCHSL. A view from the southwest. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  11. 20. Mill River and rear of the 1860 armory building, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Mill River and rear of the 1860 armory building, c. 1930. Photocopied from a print of a film negative, NHCHSL. View from the south. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  12. Microbial Protein-Antigenome Determination (MAD) Technology: A Proteomics-Based Strategy for Rapid Identification of Microbial Targets of Host Humoral Immune Responses

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Immunogenic, pathogen-specific proteins have excellent potential for development of novel management modalities. Here, we describe an innovative application of proteomics called Microbial protein-Antigenome Determination (MAD) Technology for rapid identification of native microbial proteins that eli...

  13. 16. Historic American Buildings Survey (Fed.) Stanley P. Mixon, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Historic American Buildings Survey (Fed.) Stanley P. Mixon, Photographer May 16, 1940 (O) INTERIOR OF ATTIC, LOOKING WEST OVER BALLROOM, SHOWING OLD LOG RAFTERS & 'SPLIT' OR OPEN RIDGE POLE. - Eli Adams House, Oakham, Worcester County, MA

  14. What Is Geometry?

    ERIC Educational Resources Information Center

    Chern, Shiing-Shen

    1990-01-01

    Discussed are the major historical developments of geometry. Euclid, Descartes, Klein's Erlanger Program, Gaus and Riemann, globalization, topology, Elie Cartan, and an application to molecular biology are included as topics. (KR)

  15. 13. Historic American Buildings Survey (Fed.) Stanley P. Mixon, Photographer ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Historic American Buildings Survey (Fed.) Stanley P. Mixon, Photographer May 16, 1940 (K) INT. DETAIL OF PART OF FEATHER EDGE PANELING AND DOOR (NORTHEAST ROOM, FIRST FLOOR) - Eli Adams House, Oakham, Worcester County, MA

  16. IMMUNOCHEMICAL DETERMINATION OF DIOXINS IN SEDIMENT SAMPLES

    EPA Science Inventory

    Polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) are considered highly toxic contaminants with the environmental monitoring of these compounds being of great importance. Immunoassay procedures such as the enzyme-linked immunosorbent assay (ELIS...

  17. Characterization and Mitigation of Resistive Losses in a Large Area Laser Power Converter

    DTIC Science & Technology

    2014-03-27

    CHARACTERIZATION AND MITIGATION OF RESISTIVE LOSSES IN A LARGE AREA LASER POWER CONVERTER THESIS Eli A. Garduño, Second Lieutenant, USAF AFIT-ENP-14...LOSSES IN A LARGE AREA LASER POWER CONVERTER THESIS Presented to the Faculty Department of Engineering Physics Graduate School of Engineering and...DISTRIBUTION UNLIMITED. AFIT-ENP-14-M-09 CHARACTERIZATION AND MITIGATION OF RESISTIVE LOSSES IN A LARGE AREA LASER POWER CONVERTER Eli A. Garduño, BS

  18. Analysis of state Superfund programs: 50 state study. 1998 update

    SciTech Connect

    1998-12-31

    States have remediated over 40,000 contaminated sites not on the federal Superfund list. ELI`s latest analysis of state Superfund programs examines the cleanup programs of all 50 states, Puerto Rico, and the District of Columbia. The study provides the most current data on state statutes, program organization, staffing, funding, expenditures, cleanup standards, and cleanup activities, voluntary cleanup programs and brownfields programs. State and federal policymakers and attorneys working on non-NPL sites should find this study useful.

  19. Antibody-Mediated Targeting of Alpha PDGF Receptor to Inhibit the Progression of Skeletal Micro-Metastases

    DTIC Science & Technology

    2012-10-01

    and one of the images also selected for the cover page. Furthermore, our study contributed in a determinant manner to persuade ImClone/ Eli Lilly to...Molecules and events implicated in skeletal metastasis from prostate cancer”. Philadelphia. PA (Presented by Alessandro Fatatis) (2009). - ImClone – Eli ...Mike Russell, degree awarded in April 2010 - Whitney Jamieson, degree awarded in April 2010 - Julia Fox D’Ambrosio, degree awarded in April

  20. Risky Business: Reducing Moral Hazard in Airlift Operations

    DTIC Science & Technology

    2012-06-01

    provided were much more suitable for this task. In discussing this option with Colonel Casey, 483rd Troop Carrier Wing Commander, Gen Ely , French...government of France, and thus his comments clearly indicate French behavior was influenced by insurance provided by the US. However, even if Ely did not...17 engine, the Pratt and Whitney F117, with its civilian counterpart the Pratt and Whitney 2040, which powers the Boeing 757 (B757).24 As would be

  1. High intensity X/γ photon beams for nuclear physics and photonics

    NASA Astrophysics Data System (ADS)

    Serafini, L.; Alesini, D.; Bacci, N.; Bliss, N.; Cassou, K.; Curatolo, C.; Drebot, I.; Dupraz, K.; Giribono, A.; Petrillo, V.; Palumbo, L.; Vaccarezza, C.; Variola, A.; Zomer, F.

    2016-05-01

    In this manuscript we review the challenges of Compton backscattering sources in advancing photon beam performances in the 1 - 20 MeV energy range, underlining the design criteria bringing to maximum spectral luminosity and briefly describing the main achievements in conceiving and developing new devices (multi-bunch RF cavities and Laser recirculators) for the case of ELI-NP Gamma Beam System (ELI-NP-GBS).

  2. Multi-Level Scenario Module 1: 7th Division

    DTIC Science & Technology

    2009-03-01

    included in this documentation. Please refer any questions reference the two versions of the documentation to TRAC PRD or SWGD. 14 . ABSTRACT Multi...Rio Grande. • Elis threatens the water supply to Attica unless paramilitary and terrorist support ceases. 2- 14 • U.S. cruise missiles...agreement on deployment of forces into Paros and Messenia. • 2 AEFs and AMD units receive order to deploy to GCC AOR (Elis, Messenia, and Paros

  3. Following electron impact excitation of single (N, O, F, Ne, Na, Mg, Al, Si) atom L subshells ionization cross section calculations by using Lotz's equation

    NASA Astrophysics Data System (ADS)

    Aydinol, Mahmut

    2017-02-01

    L shell and L subshells ionization cross sections σL and σLi (i = 1, 2, 3) following electron impact on (N,O, F, Ne, Na, Mg, Al, Si) atoms calculated. By using Lotz' equation for nonrelativistic cases in Matlab σL and σLi cross section values obtained for ten electron impact(Eo) values in the range of ELiELi(but only for Na 8ELi) for each atom. Starting from Eo=ELi(each subshell ionization threshold energy), σL and σLi are increasing rapidly with Eo. For a fixed Eo value(≈3.ELi), while Z value increases from 7≤Z≤14 σL and σLi decrease. Results show that for smaller values of Eo(close to ELi), x-ray yields formation of Li(i=1,2,3) subshells decreases while competing other yields are increase. Results may help to understand similar findings which obtained from other electron impact excitation of L shell σL and subshells σLi studies for single atoms.

  4. A bioinspired elastin-based protein for a cytocompatible underwater adhesive.

    PubMed

    Brennan, M Jane; Kilbride, Bridget F; Wilker, Jonathan J; Liu, Julie C

    2017-04-01

    The development of adhesives that can be applied and create strong bonds underwater is a significant challenge for materials engineering. When the adhesive is intended for biomedical applications, further criteria, such as biocompatibility, must be met. Current biomedical adhesive technologies do not meet these needs. In response, we designed a bioinspired protein system that shows promise to achieve biocompatible underwater adhesion coupled with environmentally responsive behavior that is "smart" - that is, it can be tuned to suit a specific application. The material, ELY16, is constructed from an elastin-like polypeptide (ELP) that can be produced in high yields from Escherichia coli and can coacervate in response to environmental factors such as temperature, pH, and salinity. To confer wet adhesion, we utilized design principles from marine organisms such as mussels and sandcastle worms. When expressed, ELY16 is rich in tyrosine. Upon modification with the tyrosinase enzyme to form mELY16, the tyrosine residues are converted to 3,4-dihydroxyphenylalanine (DOPA). Both ELY16 and mELY16 exhibit cytocompatibility and significant dry adhesion strength (>2 MPa). Modification with DOPA increases protein adsorption to glass and provides moderate adhesion strength (∼240 kPa) in a highly humid environment. Furthermore, this ELP exhibits a tunable phase transition behavior that can be formulated to coacervate in physiological conditions and provides a convenient mechanism for application underwater. Finally, mELY16 possesses significantly higher adhesion strength in dry, humid, and underwater environments compared with a commercially available fibrin sealant. To our knowledge, mELY16 provides the strongest bonds of any rationally designed protein when used completely underwater, and its high yields make it more viable for commercial application compared to natural adhesive proteins. In conclusion, this ELP shows great potential to be a new "smart" underwater adhesive.

  5. Development of an Anti-Elicitin Antibody-Based Immunohistochemical Assay for Diagnosis of Pythiosis

    PubMed Central

    Inkomlue, Ruchuros; Larbcharoensub, Noppadol; Karnsombut, Patcharee; Lerksuthirat, Tassanee; Aroonroch, Rangsima; Lohnoo, Tassanee; Yingyong, Wanta; Santanirand, Pitak; Sansopha, Lalana

    2015-01-01

    Pythiosis is an emerging and life-threatening infectious disease of humans and animals living in tropical and subtropical countries and is caused by the fungus-like organism Pythium insidiosum. Antifungals are ineffective against this pathogen. Most patients undergo surgical removal of the infected organ, and many die from advanced infections. Early and accurate diagnosis leads to prompt management and promotes better prognosis for affected patients. Immunohistochemical assays (IHCs) have been developed using rabbit antibodies raised against P. insidiosum crude extract, i.e., culture filtrate antigen (CFA), for the histodiagnosis of pythiosis, but cross-reactivity with pathogenic fungi compromises the diagnostic performance of the IHC. Therefore, there is a need to improve detection specificity. Recently, the elicitin protein, ELI025, was identified in P. insidiosum, but it was not identified in other human pathogens, including true fungi. The ELI025-encoding gene was successfully cloned and expressed as a recombinant protein in Escherichia coli. This study aims to develop a new IHC using the rabbit anti-ELI025 antibody (anti-ELI) and to compare its performance with the previously reported anti-CFA-based IHC. Thirty-eight P. insidiosum histological sections stained positive by anti-ELI-based and anti-CFA-based IHCs indicating 100% detection sensitivity for the two assays. The anti-ELI antibody stained negative for all 49 negative-control sections indicating 100% detection specificity. In contrast, the anti-CFA antibody stained positive for one of the 49 negative controls (a slide prepared from Fusarium-infected tissue) indicating 98% detection specificity. In conclusion, the anti-ELI based IHC is sensitive and specific for the histodiagnosis of pythiosis and is an improvement over the anti-CFA-based assay. PMID:26719582

  6. Following electron impact excitation of single (Sc, Ti, V, Cr, Mn, Fe, Co, Ni) atom L subshells ionization cross section calculations by using Lotz's equation

    NASA Astrophysics Data System (ADS)

    Aydinol, Mahmut

    2017-02-01

    L shell and Li subshells ionization cross sections[σL and σLi i = 1, 2, 3 following electron impact on (Sc, Ti, V, Cr, Mn, Fe, Co, Ni) atoms calculated. By using Lotz' equation for non-relativistic cases in Matlab σL and σLi cross section values obtained for ten electron impact(Eo) values in the range of ELiELi for each atom. Starting from Eo=ELi(each subshell ionization threshold energy), σL and σLi are increasing rapidly with Eo. For a fixed Eo value(≈3.ELi), while Z value increases from 21≤Z≤28 σL and σLi decrease. Results show that for smaller values of Eo(close to ELi), x-ray yields formation of Li(i =1,2,3) subshells decreases while competing other yields are increase. Results may help to understand similar findings which obtained from other electron impact excitation of L shell σL, Li subshells σLi studies for single atoms.

  7. Detection of antinuclear antibodies by indirect immunofluorescence and by solid phase assay.

    PubMed

    Op De Beeck, Katrijn; Vermeersch, Pieter; Verschueren, Patrick; Westhovens, René; Mariën, Godelieve; Blockmans, Daniel; Bossuyt, Xavier

    2011-10-01

    Testing for antinuclear antibodies is useful for the diagnosis of systemic rheumatic diseases. Solid phase assays are increasingly replacing indirect immunofluorescence for detection of antinuclear antibodies. In the most recent generation of solid phase assays, manufacturers attempt to improve the performance of the assays by adding extra antigens. Solid phase assay (EliA CTD Screen, Phadia, in which antibodies to 17 antigens are detected) was compared to indirect immunofluorescence for the detection of antinuclear antibodies in diagnostic samples of 236 patients with autoimmune connective tissue diseases, in 149 healthy blood donors, 139 patients with chronic fatigue syndrome, and 134 diseased controls. The sensitivity of EliA CTD Screen for systemic lupus erythematosus, systemic sclerosis, primary Sjögren's syndrome, mixed connective tissue disease, and inflammatory myopathy was 74%, 72%, 89%, 100%, and 39%, respectively. The reactivity in blood donors, in patients with chronic fatigue syndrome, and in diseased controls was <4%. Likelihood ratios increased with increasing antibody concentrations. Generally, a positive test result by EliA CTD Screen had a higher likelihood ratio for systemic rheumatic disease than a positive test result by indirect immunofluorescence. A negative test result by indirect immunofluorescence, however, had a lower likelihood ratio than a negative test result by EliA CTD Screen, indicating that the negative predictive value was higher for indirect immunofluorescence than for EliA CTD screen.

  8. Binary Classifier Calibration Using an Ensemble of Linear Trend Estimation

    PubMed Central

    Naeini, Mahdi Pakdaman; Cooper, Gregory F.

    2017-01-01

    Learning accurate probabilistic models from data is crucial in many practical tasks in data mining. In this paper we present a new non-parametric calibration method called ensemble of linear trend estimation (ELiTE). ELiTE utilizes the recently proposed ℓ1 trend ltering signal approximation method [22] to find the mapping from uncalibrated classification scores to the calibrated probability estimates. ELiTE is designed to address the key limitations of the histogram binning-based calibration methods which are (1) the use of a piecewise constant form of the calibration mapping using bins, and (2) the assumption of independence of predicted probabilities for the instances that are located in different bins. The method post-processes the output of a binary classifier to obtain calibrated probabilities. Thus, it can be applied with many existing classification models. We demonstrate the performance of ELiTE on real datasets for commonly used binary classification models. Experimental results show that the method outperforms several common binary-classifier calibration methods. In particular, ELiTE commonly performs statistically significantly better than the other methods, and never worse. Moreover, it is able to improve the calibration power of classifiers, while retaining their discrimination power. The method is also computationally tractable for large scale datasets, as it is practically O(N log N) time, where N is the number of samples. PMID:28357158

  9. The reliability of the Extra Load Index as a measure of relative load carriage economy.

    PubMed

    Hudson, Sean; Cooke, Carlton; Lloyd, Ray

    2017-02-01

    The aim of this study was to measure the reliability of the extra load index (ELI) as a method for assessing relative load carriage economy. Seventeen volunteers (12 males, 5 females) performed walking trials at 3 km·h(-1), 6 km·h(-1) and a self-selected speed. Trial conditions were repeated 7 days later to assess test-retest reliability. Trials involved four 4-minute periods of walking, each separated by 5 min of rest. The initial stage was performed unloaded followed in a randomised order by a second unloaded period and walking with backpacks of 7 and 20 kg. Results show ELI values did not differ significantly between trials for any of the speeds (p = 0.46) with either of the additional loads (p = 0.297). The systematic bias, limits of agreement and coefficients of variation were small in all trial conditions. We conclude the ELI appears to be a reliable measure of relative load carriage economy. Practitioner Summary: This paper demonstrates that the ELI is a reliable measure of load carriage economy at a range of walking speeds with both a light and heavy load. The ELI, therefore, represents a useful tool for comparing the relative economy associated with different load carriage systems.

  10. [Effect of 3-oxypyridine and succinic acid derivatives on endometrial leucocyte infiltration and lipid peroxidation in recrudescence of inflammatory diseases of the uterus and its appendages].

    PubMed

    Volchegorskiĭ, I A; Pravdin, E V; Uzlova, T V

    2013-01-01

    The effect of domestic 3-oxypyridine and succinic acid derivatives (emoxipin, reamberin and mexidol) included in the complex treatment of recrudescence of inflammatory diseases of the uterus and its appendages, as manifested in endometrial leucocyte infiltration (ELI) compared to lipid peroxidation products concentration in blood serum, was assessed in a short-term, prospective placebo-controlled single-blind randomized trial. It has been found that two-week infusions of emoxipin (single dose, 150 mg), reamberin (single dose, 400 ml), and mexidol (single dose, 300 mg) favor a decrease in ELI and influence ambiguously on lipid peroxidation - antioxidant (LPA) system condition in blood serum of patients. It has been found that 3-oxypyridine derivative (emoxipin) decreases the intensity of ELI, but does not affect LPA system condition. Succinic acid derivative (reamberin) is inferior to emoxipin in the degree of decreasing ELI, but reduces the concentration of the antioxidant protein ceruloplasmin. Mexidol, being 3-oxipyridine and succinic acid derivative simultaneously, exceeds reamberin in decreasing ELI, increases concentration of blood antioxidant components (alpha-tocopherol and ceruloplasmin), and decreases the level of primary isopropanol-soluble products of lipid peroxidation.

  11. Improved vectors for expression library immunization--application to Mycoplasma hyopneumoniae infection in pigs.

    PubMed

    Moore, R J; Lenghaus, C; Sheedy, S A; Doran, T J

    2001-10-12

    Expression library immunization (ELI) has previously been used in a number of disease models in mice. Here, we describe the first example of the application of ELI to a large animal model with the immunization of pigs against enzootic pneumonia, a disease caused by Mycoplasma hyopneumoniae. The development of new plasmid vectors and library screening methods facilitated the application of ELI to this disease by allowing random libraries to be screened for clones expressing recombinant proteins. In this way the vast majority of clones in random libraries that are unproductive can be eliminated, meaning that libraries are more likely to give protection and are subsequently easier to further screen and analyze. By using this approach we have used one library screen and two animal trials to progress from an original library of 20,000 clones to a group of just 96 clones.

  12. 31. WEST TO PARTS AND TOOLS LOCATED DIRECTLY OPPOSITE FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. WEST TO PARTS AND TOOLS LOCATED DIRECTLY OPPOSITE FROM THE BLACKSMITH SHOP AREA IN THE NORTHEAST QUADRANT OF THE FACTORY. ON THE FLOOR AT THE LEFT SIDE IS A MANUAL PIPE THREADER FOR LARGE-DIAMETER PIPE (AS DROP PIPE IN WELLS FOR WATER SYSTEMS). BENEATH THE BENCH ARE UNMACHINED NEW OLD STOCK MAIN CASTINGS FOR ELI WINDMILLS, TOGETHER WITH A USED MAIN SHAFT/WHEEL HUB/CRANK PLATE ASSEMBLY WITH 1920S-1930S OIL RESERVOIR FROM ELI WINDMILL. THE CIRCULAR CASTING WITH CRESCENT-SHAPED PATTERNS IS A PORTION OF THE CAM MECHANISM FROM A 'WESTERN GEARED GEARLESS' WINDMILL MADE BY THE WESTERN LAND ROLLER CO., HASTINGS, NEB. TO THE RIGHT ON THE BENCH IS A GEARED TIRE BENDER USED TO GIVE CURVATURE TO WHEEL RIMS OF ELI WINDMILLS. IN THE BACKGROUND ARE ... - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  13. Rb-Sr ages of the Archean rocks from the Vermilion district, northeastern Minnesota

    NASA Technical Reports Server (NTRS)

    Jahn, B.-M.; Murthy, V. R.

    1975-01-01

    The Vermilion district in Northeastern Minnesota is a classic example of a lower Precambrian greenstone-granite terrane in the Superior Province of the Canadian Shield. The present study presents new Rb-Sr isotopic data for the Ely Greenstone, the Newton Lake Formation, granitic pebbles that occur within the Ely Greenstone, a graywacke composite of the Knife Lake Group, and some Algoman granites whose data are complementary to those of Peterman et al. (1972). The isochron ages obtained are statistically indistinguishable and therefore cannot be used to resolve the timing of specific geologic events. Volcanic extrusion, granitic intrusion, and metamorphism are shown to be less contemporaneous events which probably took place within a time span of less than 50 m.y. A major conclusion is that a granitic basement probably did not underlie the Ely Greenstone.

  14. Estimates for production of radioisotopes of medical interest at Extreme Light Infrastructure - Nuclear Physics facility

    NASA Astrophysics Data System (ADS)

    Luo, Wen; Bobeica, Mariana; Gheorghe, Ioana; Filipescu, Dan M.; Niculae, Dana; Balabanski, Dimiter L.

    2016-01-01

    We report Monte Carlo simulations of the production of radioisotopes of medical interest through photoneutron reactions using the high-brilliance γ-beam of the Extreme Light Infrastructure - Nuclear Physics (ELI-NP) facility. The specific activity for three benchmark radioisotopes, 99Mo/99Tc, 225Ra/225Ac and 186Re, was obtained as a function of target geometry, irradiation time and γ-beam energy. Optimized conditions for the generation of these radioisotopes of medical interest with the ELI-NP γ-beams were discussed. We estimated that a saturation specific activity of the order of 1-2 mCi/g can be achieved for thin targets with about one gram of mass considering a γ-beam flux of 10^{11} photons/s. Based on these results, we suggest that the ELI-NP facility can provide a unique possibility for the production of radioisotopes in sufficient quantities for nuclear medicine research.

  15. Transport and dosimetric solutions for the ELIMED laser-driven beam line

    NASA Astrophysics Data System (ADS)

    Cirrone, G. A. P.; Romano, F.; Scuderi, V.; Amato, A.; Candiano, G.; Cuttone, G.; Giove, D.; Korn, G.; Krasa, J.; Leanza, R.; Manna, R.; Maggiore, M.; Marchese, V.; Margarone, D.; Milluzzo, G.; Petringa, G.; Sabini, M. G.; Schillaci, F.; Tramontana, A.; Valastro, L.; Velyhan, A.

    2015-10-01

    Within 2017, the ELIMED (ELI-Beamlines MEDical applications) transport beam-line and dosimetric systems for laser-generated beams will be installed at the ELI-Beamlines facility in Prague (CZ), inside the ELIMAIA (ELI Multidisciplinary Applications of laser-Ion Acceleration) interaction room. The beam-line will be composed of two sections: one in vacuum, devoted to the collecting, focusing and energy selection of the primary beam and the second in air, where the ELIMED beam-line dosimetric devices will be located. This paper briefly describes the transport solutions that will be adopted together with the main dosimetric approaches. In particular, the description of an innovative Faraday Cup detector with its preliminary experimental tests will be reported.

  16. Watershed Restoration Project

    SciTech Connect

    Julie Thompson; Betsy Macfarlan

    2007-09-27

    In 2003, the U.S. Department of Energy issued the Eastern Nevada Landscape Coalition (ENLC) funding to implement ecological restoration in Gleason Creek and Smith Valley Watersheds. This project was made possible by congressionally directed funding that was provided through the US Department of Energy, Energy Efficiency and Renewable Energy, Office of the Biomass Program. The Ely District Bureau of Land Management (Ely BLM) manages these watersheds and considers them priority areas within the Ely BLM district. These three entities collaborated to address the issues and concerns of Gleason Creek and Smith Valley and prepared a restoration plan to improve the watersheds’ ecological health and resiliency. The restoration process began with watershed-scale vegetation assessments and state and transition models to focus on restoration sites. Design and implementation of restoration treatments ensued and were completed in January 2007. This report describes the restoration process ENLC undertook from planning to implementation of two watersheds in semi-arid Eastern Nevada.

  17. [Efficiency of a combination of haloaerosols and helium-neon laser in the multimodality treatment of patients with bronchial asthma].

    PubMed

    Faradzheva, N A

    2007-01-01

    A hundred and thirty-eight patients with infection-dependent bronchial asthma, including 73 with moderate persistent asthma and 65 with severe persistent one, were examined. Four modes of a combination of traditional (drug) therapy (DT) and untraditional (halotherapy (HT) and endobronchial helium-neon laser irradiation (ELI) one were used. The efficiency of the treatment performed was evaluated, by determining the time course of clinical symptoms of the disease on the basis of scores of their magnitude and the patients' condition. The findings indicated that in moderate persistent asthma, both HT and ELI in combination with DT exerted an equal therapeutic effect, which provided a good and excellent condition in 83.3% of cases. In severe persistent asthma, such a condition was achieved in 93.75% of cases only when multimodality treatment involving DT, HT, and ELI had been performed.

  18. Reuse research plans at Langley Research Center

    NASA Technical Reports Server (NTRS)

    Voigt, Susan J.; Walker, Carrie

    1989-01-01

    The reuse activities at Langley have centered on the development of the Eli System by SPS. The development of a computer systems design environment at Langley was described as a target application for the future Eli system. This environment combines software development tools with an architecture design and analysis tool. Specifically, a Computer-Aided Software Engineering (CASE) system, under development at Charles Stark Draper Laboratory for Langley, is being used to generate Ada code for use in architecture functional simulations using the Architecture Design and Assessment System (ADAS). The Eli system will be included in this tool set and will be used to organize and promote reuse of the functional simulation code modules.

  19. M-X Environmental Technical Report. Environmental Characteristics of Alternative Designated Deployment Areas, Technical Report on Noise.

    DTIC Science & Technology

    1980-12-22

    traffic volumes, Beryl, Utah . 14 2.3-2 1992 traffic volumes, Beryl, Utah . 15 2.3-3 1978 traffic volumes, Clovis, New Mexico. 16 2.3-4 1992 traffic volumes...1975 traffic volumes, Dalhart, Texas. 20 2.3-8 1992 traffic volumes, Dalhart, Texas. 21 2.3-9 1978 traffic volumes, Delta, Utah . 22 2.3-10 1992...traffic volumes, Delta, Utah . 23 2.3-11 1979 traffic volumes, Ely, Nevada. 24 2.3-12 1992 traffic volumes, Ely, Nevada. 25 2.3-13 1978 traffic volumes

  20. Characterization and Targeting of the Aldehyde Dehydrogenase Subpopulation in Ovarian Cancer

    DTIC Science & Technology

    2012-07-01

    Mann– Whitney U test. Differences between groups were considered statistically significant at P < 0.05. Error bars represent SD unless otherwise stated...SK, Lopez-Berestein G, Bar- Eli MM, Sood AK. Effects of IL-8 targeted therapy with liposome incorporated siRNA on ovarian cancer growth. JNCI 100(5...38. Lu C, Shahzad MMK, Wang H, Landen CN, Kim SW, Allen J, Nick AM, Jennings N, Kinch MS, Bar- Eli M, Sood AK. EphA2 Overexpression Promotes Ovarian

  1. New light in nuclear physics: The extreme light infrastructure

    NASA Astrophysics Data System (ADS)

    Balabanski, D. L.; Popescu, R.; Stutman, D.; Tanaka, K. A.; Tesileanu, O.; Ur, C. A.; Ursescu, D.; Zamfir, N. V.

    2017-01-01

    Extreme Light Infrastructure-Nuclear Physics (ELI-NP), to become operational in 2019, is a new Research Center built in Romania that will use extreme electromagnetic fields for nuclear physics research. The ELI-NP facility will combine two large equipments with state-of-the-art parameters, namely a 2 × 10 PW high-power laser system and a very brilliant gamma-beam system delivering beams with energies up to 19.5 MeV. The laser and gamma-beam systems under construction and typical proposed first-phase experiments are described.

  2. Optical Acquisition, Image and Data Compression

    DTIC Science & Technology

    1988-07-30

    1Q80. pp. 478-480 3. D G Hubei and T N. Wiesel . Receptive fields. binocular interaction, and functional architecture in the cat’s visual cortex, J...input or two phase-conjugate signal, as lon, as E4 and Eli beams counter- 194 APPLIED OPTICS Vol. 26. No 2 / 15 January 1987 - ’ - - ------------ Table...flexible arrangement. Fm i C ’rclxi n ,I thi- ii rlapped inputs a ith 1-ir shifted A Next. ist~the NIAI u- elI as a real-time triple-irodi i :r.1

  3. Near East/South Asia Report; No. 2802

    DTIC Science & Technology

    2007-11-02

    83) 2 Ben-Eli’ezer’s Policy Analyzed ( David Richardson; THE JERUSALEM POST, 22 Jul 83) 9 Arrangement With Agudat Yisra’el To Affect...CSO: 4400/437 ISRAEL BEN-ELI’EZER’S POLICY ANALYZED TA220736 Jerusalem THE JERUSALEM POST in English 22 Jul 83 p 7 [Commentary by David ...no more than the beginning of a new cycle of events similar to the 5 years of decline in relations which followed the Camp David accords. In

  4. Molecular Mechanisms of Microbially Facilitated Corrosion

    DTIC Science & Technology

    1986-10-23

    AD-A173 862 MOLECULAR MECHANISMS OF MICR38IRLLY FACILITATED 1/2 CORROSION(U) TENNESSEE UNIV K~NOXVILLE INST FOR APPLIED MICROBIOLOGY D C WHITE 23 OCT...of Tennessee 10515 Research Drive, Building # 1, Suite 300 Knoxville, Tennessee 37932-2567 N 615-675-9520 October 23, 1986 00 Dr. Eli D . Schmell ELECTE...V) Program Manager, Molecular Biology NOV 4 NO8 Code 041M - Office of Naval Research 800 North Quincy Street D Arlington, VA 22217-5000. Dear Eli

  5. Status Report on Speech Research.

    DTIC Science & Technology

    1987-09-01

    1968; Ladefoged, 1975). bTbe words are written in current Zulu orthography (which is based on the Roman alphabet), in which <c> corresponds to the...Hammerich, R. Jakobson , & E. Zwirner (Eds.), Form and substance: Phonetic and linguistic papers presented to Eli Fischer-Jorgensen (pp. 221-231

  6. Chemical and Hot Water Treatments to Eliminate Rhizoctonia From Azalea Stem Cuttings: Failures and Successes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Azalea web blight is an annual problem on some evergreen azalea cultivars grown in containerized nursery production in the southern and eastern United States. The binucleate Rhizoctonia species, which cause the disease, are spread on new shoot growth harvested for propagation. Rhizoctonia can be eli...

  7. Rooting Response of Azalea Cultivars Using Hot Water Treatments to Control Pathogens

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Azalea web blight is an annual problem on some evergreen azalea cultivars grown in containerized nursery production in the southern and eastern United States. The binucleate Rhizoctonia species, which cause the disease, are spread on new shoot growth harvested for propagation. Rhizoctonia can be eli...

  8. 76 FR 70730 - Privacy Act of 1974; Department of Homeland Security/U.S. Citizenship and Immigration Services...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-15

    ...), vaccinations, and medical referrals. In the first release of USCIS ELIS, USCIS collects information from the... Grounds of Inadmissibility (1615-0029), 06/30/12; I-693--Report of Medical Examination and Vaccination... Relationships (e.g., Parent, Spouse, Sibling, Child, Other Dependents, etc., as well as polygamy,...

  9. Boot Camp for Education CEOs: The Broad Foundation Superintendents Academy

    ERIC Educational Resources Information Center

    Jehlen, Alain

    2012-01-01

    The Broad Foundation Superintendents Academy is the most prominent and most controversial training institute for school chiefs. The Academy is the flagship program of the Eli and Edythe Broad Foundation, the smallest of a triumvirate of corporate foundations that are at the heart of the billionaire campaign to remake public education in the image…

  10. Short-Term Memory (STM) Constraints in Children with Specific Language Impairment (SLI): Are There Differences between Receptive and Expressive SLI?

    ERIC Educational Resources Information Center

    Nickisch, Andreas; von Kries, Rudiger

    2009-01-01

    Purpose: Specific language impairment (SLI) is assumed to be causally related to deficits in auditory short-term memory (STM). Although verbal STM deficits have been consistently found in SLI, the results of visual STM tests are inconsistent. Do these inconsistencies reflect different study populations of expressive SLI (ELI) and…

  11. Crew Stress and Fatigue in the PAVE LOW III System

    DTIC Science & Technology

    1980-07-01

    you feel RIGIIT NOW. STATEMENT [ETTER THAN SAME AS WORSE THAN t. VERY LIVELY 2. EXTREMELf TIRED 3. QUITE FRESH 4. St IGHTLY POOPED S. EXTREmELY rEPFY I...J 6 COMEWHAT FRESH I 7. PETERED OUT z 8. VERY REFRESHED _ I 9. FAIRLY WELL POOPED o 10. kEAOY TO DROP skm 1 36 SUBJECTIVE FATIGUE CHCCKCARD 15

  12. Networked Success and Failure at Hybritech

    ERIC Educational Resources Information Center

    Jones, Mark Peter

    2011-01-01

    The author presents an historical account of scientific work conducted at a commercial biotech firm in San Diego called Hybritech. It tells of disruptions in research programs following the acquisition of the company by the pharmaceutical giant Eli Lilly in 1986. The story centers on responses to an organizational challenge that research managers…

  13. The Confidence to Make a Difference

    ERIC Educational Resources Information Center

    Stanistreet, Paul

    2012-01-01

    Popularly known as "the biggest housing estate in Europe", Ely is the most deprived area of Cardiff and one of the most disadvantaged parts of the UK. It has, by the admission of its own residents, a bad reputation as an area associated with poverty, gangs, street crime and burnt-out cars. That is only one part of the story. Those who…

  14. Reactivity Differences between [alpha, beta]-Unsaturated Carbonyls and Hydrazones Investigated by Experimental and Theoretical Electron Density and Electron Localizability Analyses

    SciTech Connect

    Grabowsky, Simon; Weber, Manuela; Jayatilaka, Dylan; Chen, Yu-Sheng; Grabowski, Matthias T.; Brehme, Rainer; Hesse, Malte; Schirmeister, Tanja; Luger, Peter

    2012-10-11

    It is still a challenge to predict a compound's reactivity from its ground-state electronic nature although Bader-type topological analyses of the electron density (ED) and electron localizability indicator (ELI) give detailed and useful information on electron concentration and electron-pair localization, respectively. Both ED and ELI can be obtained from theoretical calculations as well as high-resolution X-ray diffraction experiments. Besides ED and ELI descriptors, the delocalization index is used here; it is likewise derived from theoretical calculations as well as from experimental X-ray results, but in the latter case, demonstrated here for the first time. We investigate {alpha},{beta}-unsaturated carbonyl and hydrazone compounds because resonance exhibited by these compounds in the electronic ground-state determines their reactive behavior. The degree of resonance as well as the reactivity contrast are quantified with the electronic descriptors. Moreover, competitive mesomeric substituent effects are studied using the two biologically important compounds acrolein and acrylamide. The reactivity differences predicted from the analyses are in line with the known reactivity of these compounds in organic synthesis. Hence, the capability of the ED and ELI for rationalizing and predicting different and competing substituent effects with respect to reactivity is demonstrated.

  15. 9. Town of Hamden, 1868 Map detail photocopied from F. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. Town of Hamden, 1868 Map detail photocopied from F. W. Beers, et al., Atlas of New Haven County, Connecticut (New York, 1868), p. 25. Shows the newly created Lake Whitney and, one quarter mile south of the armory, a 'Rifle Factory.' - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  16. 75 FR 21365 - Investigations Regarding Certifications of Eligibility To Apply for Worker Adjustment Assistance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ...). 73775 Eli Lilly & Company (wkrs). Indianapolis, IN...... 03/24/10 03/22/10 73776 Workshops of G.E. Henn... MeadWestVaco (Workers)..... Richmond, VA 03/25/10 03/19/10 73791 Burlington Technologies Burlington,...

  17. Online Information Retrieval for Economists: The Economic Literature Index.

    ERIC Educational Resources Information Center

    Ekwurzel, Drucilla; Saffran, Bernard

    1985-01-01

    The basics of online searching for bibliographic citations are presented through use of the "Economic Literature Index" (ELI), which is available as File 139 on Dialog Information Services. This article focuses on the choice of media for bibliographic searches, search strategies, and the selection of alternative databases, such as…

  18. Investigating the News Seeking Behavior of Young Adults

    ERIC Educational Resources Information Center

    Qayyum, M. Asim; Williamson, Kirsty; Liu, Ying-Hsang; Hider, Philip

    2010-01-01

    This study investigated the news-seeking and browsing behaviours of young adults, partly in the context of everyday life information seeking (ELIS), in order to explore their perceptions of and attitudes towards print and online news media. The study is significant because traditional print newspapers face a steady decline in their readership with…

  19. Applying Diversity Management Concepts to Improve the Minority Educational Pipeline

    ERIC Educational Resources Information Center

    Oguntebi, Joy; Shcherbakova, Maria; Wooten, Lynn P.

    2012-01-01

    The objective of this conceptual article is to investigate existing diversity management paradigms and extend their implications toward the goal of increasing minority representation in management education. We suggest that the existing learning-and-effectiveness diversity management paradigm (Thomas & Ely, 1996, "Harvard Business…

  20. The Transformation of the Urban Economic Base. Special Report No. 19.

    ERIC Educational Resources Information Center

    Stanback, Thomas, Jr.; Drennan, Matthew

    The objective stated for this monograph is to provide some insights regarding the nature of urban economic systems and their growth processes which will be useful in formulating developmental policy. A foreword (by Eli Ginzberg) provides background on the history of and present challenge to reshape manpower policies and programs for cities…

  1. The Learning Age: Experts Give Their Views on the Government's Green Paper.

    ERIC Educational Resources Information Center

    Adults Learning (England), 1998

    1998-01-01

    Includes reactions to "The Learning Age" from the following: A.G. Watts, Richard Taylor, Richard Ely, Carole Stott, Donald Rae, John Lawton, Philippa Langton, Mary Lord, and Sarah Perman. Emphasizes the need for practitioner input from their varied experiences and for knowledge of client groups into the continuing development of the…

  2. Academic Freedom on Trial: 100 Years of Sifting and Winnowing at the University of Wisconsin-Madison.

    ERIC Educational Resources Information Center

    Hansen, W. Lee, Ed.

    The 29 papers in this collection celebrate academic freedom at the University of Wisconsin-Madison and are organized around the 1894 "trial" of Richard T. Ely, an economist who was exonerated of fomenting unrest and discussing "dangerous" ideas in a Board of Regents Statement which stressed the importance of "sifting and…

  3. SITE TECHNOLOGY CAPSULE; MULTI-VENDOR BIOREMEDIATION DEMONSTRATION PROJECT: ENVIRONMENTAL LABORATORIES/SBP TECHNOLOGIES' UVB VACUUM VAPORIZATION WELL PROCESS

    EPA Science Inventory

    This technology capsule summarizes the findings of an evaluation of the Unterdruck-Verdampfer-Brunnen (UVB) technology developed by IEG Technologies (IEG) and licensed in the eastern United States by Environmental Laboratories, Inc. (ELI) and SBP Technologies, Inc. (SBP). This e...

  4. Teacher Evaluation as a Tool for Professional Development: A Case of Saudi Arabia

    ERIC Educational Resources Information Center

    Hakim, Badia Muntazir

    2015-01-01

    This study reports on the use of teacher evaluation and appraisal process as a tool for professional development. A group of 30 teachers from seven different nationalities with diverse qualifications and teaching experiences participated in this case study at the English Language Institute (ELI) at King Abdulaziz University (KAU), Saudi Arabia.…

  5. The 2010 Broad Prize

    ERIC Educational Resources Information Center

    Education Digest: Essential Readings Condensed for Quick Review, 2011

    2011-01-01

    A new data analysis, based on data collected as part of The Broad Prize process, provides insights into which large urban school districts in the United States are doing the best job of educating traditionally disadvantaged groups: African-American, Hispanics, and low-income students. Since 2002, The Eli and Edythe Broad Foundation has awarded The…

  6. Broad Prize: Do the Successes Spread?

    ERIC Educational Resources Information Center

    Samuels, Christina A.

    2011-01-01

    When the Broad Prize for Urban Education was created in 2002, billionaire philanthropist Eli Broad said he hoped the awards, in addition to rewarding high-performing school districts, would foster healthy competition; boost the prestige of urban education, long viewed as dysfunctional; and showcase best practices. Over the 10 years the prize has…

  7. A Study on Correlation of Risk-Taking and the Oral Production of English Majors in China

    ERIC Educational Resources Information Center

    Wang, Yang; Lin, Yuewu

    2015-01-01

    Risk-taking refers to the tendency to engage in behaviors that have the potential to be harmful or dangerous, yet at the same time provides the opportunity for some kinds of outcome that can be perceived as positive. Ely (1986) and Bang (1999) have mentioned the relationship between risk-taking and oral production in the process of English…

  8. Seizure Risk in Patients with Attention-Deficit-Hyperactivity Disorder Treated with Atomoxetine

    ERIC Educational Resources Information Center

    Wernicke, Joachim F.; Holdridge, Karen Chilcott; Jin, Ling; Edison, Timothy; Zhang, Shuyu; Bangs, Mark E.; Allen, Albert J.; Ball, Susan; Dunn, David

    2007-01-01

    The comorbidity of seizures, epilepsy, and attention-deficit-hyperactivity disorder (ADHD) prompted the examination of whether atomoxetine use for ADHD is associated with an increased risk of seizures. Seizures and seizure-related symptoms were reviewed from two independent Eli Lilly and Company databases: the atomoxetine clinical trials database…

  9. 37. NORTH TO BINS ALONG NORTH WALL OF FACTORY BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. NORTH TO BINS ALONG NORTH WALL OF FACTORY BUILDING WHICH REMAIN FILLED WITH NEW OLD STOCK AND USED PARTS FOR ELI WINDMILLS. THE ROPE AT THE LOWER FOREGROUND WAS USED IN ERECTING WINDMILLS AND TOWERS FOR CUSTOMERS. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  10. The Role of the Social Scientist in Human Resource Development Policy and Programs for Hispanics. National Symposium on Hispanics and CETA (1980).

    ERIC Educational Resources Information Center

    Furino, Antonio, Ed.

    Conference speakers focused on three topics: Hispanics and Comprehensive Employment and Training Act (CETA) policy and implementation issues; data sources; and research regarding Hispanic manpower. After introductory remarks by James W. Wagener, Eli Ginzberg and Tomas Rivera, Ernest Green discussed Hispanics and CETA. Harry Greenspan described…

  11. TESL Reporter, Vol. 11, No. 2.

    ERIC Educational Resources Information Center

    Pack, Alice C., Ed.

    This issue contains the following articles: "Progressive Decontrol through Deletion," by Robert C. Weissberg; "The Scrutable Chinese," by Jason B. Alter; "Gadgets: Some Non-Verbal Tools for Teaching Pronunciation," by Judy Gilbert; "ELI and English Skills in JFS Library-Media Complex," by Curtis Fawson; and "Aural Comprehension: Mini Lessons in…

  12. Vocational Education and Training.

    ERIC Educational Resources Information Center

    van Leeuwen, Fred, Ed.

    2000-01-01

    This issue of the quarterly Education International focuses on vocational education and training (VET). The editorial, "Education and the Wealth of Nations" (Fred van Leeuwen), focuses on provision of quality education for all. "Education International's (EI's) First Joint Worldwide Action on Education Issues" (Elie Jouen) describes the Global…

  13. Pathway-based Analysis of Fish Transcriptomics Data across Effluent Gradients in Minnesota Rivers

    EPA Science Inventory

    As part of a larger effort to assess the health of streams and rivers in Minnesota, a series of caged fish experiments were conducted in three locations: Ely, Hutchinson, and Rochester. The experimental design placed caged fish (fathead minnows, Pimephales promelas; FHM) across ...

  14. Broad Academy's Growing Reach Draws Scrutiny

    ERIC Educational Resources Information Center

    Samuels, Christina A.

    2011-01-01

    Billionaire businessman Eli Broad, one of the country's most active philanthropists, founded the "Broad Superintendents Academy" in 2002 with an extraordinarily optimistic goal: Find leaders from both inside and outside education, train them, and have them occupying the superintendencies in a third of the 75 largest school districts--all in just…

  15. The NMC Horizon Report: 2015 Higher Education Edition

    ERIC Educational Resources Information Center

    Johnson, L.; Adams Becker, S.; Estrada, V.; Freeman, A.

    2015-01-01

    The "NMC Horizon Report: 2015 Higher Education Edition" is a collaborative effort between the New Media Consortium (NMC) and the EDUCAUSE Learning Initiative (ELI). This 12th edition describes annual findings from the NMC Horizon Project, an ongoing research project designed to identify and describe emerging technologies likely to have…

  16. Leadership Profiles.

    ERIC Educational Resources Information Center

    Higgins, Norman C.; And Others

    1997-01-01

    Includes biographies of three people who have made significant contributions to the field of educational media and technology: (1) Donald P. Ely and his widespread teaching, research, and service contributions; (2) James Okey's contributions in instructional technology; and (3) Constance Dorothea Weinman as a pioneer in the use of educational…

  17. 15. Site plan, 1915, bottom half With CT214, photocopied from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. Site plan, 1915, bottom half With CT-2-14, photocopied from an ozalid print, 'Map of Plant of Sentinel Manufacturing Co.,' Folio 2, EWC. The Sentinel Manufacturing Co. produced gas stoves. They leased the Whitney Armory buildings about 1915. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  18. 25. Site plan by New Haven Water Company, c.1900 Photocopied ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    25. Site plan by New Haven Water Company, c.1900 Photocopied from property map, Mill River Division, Sheet 51, Map Collection, Armory Street Filtration Plant, New Haven Water Company, Hamden, Connecticut. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  19. 17. Forge building, fuel storage shed, and foundry, 1906 Photocopied ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. Forge building, fuel storage shed, and foundry, 1906 Photocopied from a photograph by Thomas S. Bronson, 'Group at Whitney Factory, 5 November 1906,' NHCHSL. The most reliable view of the fuel storage sheds and foundry, together with a view of the forge building. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  20. 18. View from East Rock, c. 1920 Photocopied from a ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    18. View from East Rock, c. 1920 Photocopied from a print from glass negative no. 6476 by Thomas S. Bronson, NHCHSL. An aerial view of the armory site evidently after the row of stone houses for married employees had been torn down. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  1. 22. Lake Whitney Dam, 1895 Photocopied from an original photograph, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Lake Whitney Dam, 1895 Photocopied from an original photograph, NHCHSL. Shows the rear of the dam building, and on Lake Whitney, Day's Store and Boathouse, and an ice house and steam-powered elevators. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  2. 16. Forge building and fuel storage shed from the southwest, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Forge building and fuel storage shed from the southwest, c.1918 Photocopied from a photograph in the collection of William F. Applegate, 43 Grandview Avenue, Wallingford, Connecticut. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  3. Business, Philanthropy, and Education in the United States.

    ERIC Educational Resources Information Center

    Hall, Peter Dobkin

    1994-01-01

    Traces the history of the relationship between business and public education from the 17th century through the depression, the war, and the post-liberal era; and notes the contributions of Eli Whitney, Andrew Carnegie, and other philanthropists. The article also examines the efforts to achieve social transformation through the schools. (SM)

  4. U.S. Military Action Against the Islamic State: Answers to Frequently Asked Legal Questions

    DTIC Science & Technology

    2014-09-09

    the view that provisions of WPR other than Section 5(c) do not raise facial constitutional objections); John Hart Ely , Suppose Congress Wanted a War...alleging that presidential action has violated the WPR have also proven unsuccessful. See, e.g., Whitney v. Obama, 845 F. Supp. 2d 136 (D.D.C. 2012

  5. Brilliant gamma beams for industrial applications: new opportunities, new challenges

    NASA Astrophysics Data System (ADS)

    Iancu, V.; Suliman, G.; Turturica, G. V.; Iovea, M.; Daito, I.; Ohgaki, H.; Matei, C.; Ur, C. A.; Balabanski, D. L.

    2016-10-01

    The Nuclear Physics oriented pillar of the pan-European Extreme Light Infrastructure (ELI-NP) will host an ultra-bright, energy tunable, and quasi-monochromatic gamma-ray beam system in the range of 0.2-19.5 MeV produced by laser-Compton backscattering technique. The applied research program envisioned at ELI-NP targets to use nuclear resonance fluorescence (NRF) and computed tomography to provide new opportunities for industry and society. High sensitivity NRF-based investigations can be successfully applied to safeguard applications and management of radioactive wastes as well as to uncharted fields like cultural heritage and medical imaging. Gamma-ray radioscopy and computed tomography performed at ELI-NP has the potential to achieve high resolution in industrial-sized objects provided the detection challenges introduced by the unique characteristics of the gamma beam are overcome. Here we discuss the foreseen industrial applications that will benefit from the high quality and unique characteristics of ELI-NP gamma beam and the challenges they present. We present the experimental setups proposed to be implemented for this goal, discuss their performance based on analytical calculations and numerical Monte-Carlo simulations, and comment about constrains imposed by the limitation of current scintillator detectors. Several gamma-beam monitoring devices based on scintillator detectors will also be discussed.

  6. High contrast broadband seeder for multi-PW laser system

    NASA Astrophysics Data System (ADS)

    Chalus, O.; Pellegrina, A.; Ricaud, S.; Casagrande, O.; Derycke, C.; Radier, C.; Soujaeff, A.; Matras, G.; Rey, G.; Boudjemaa, L.; Simon-Boisson, C.; Laux, S.; Lureau, F.

    2016-03-01

    A hybrid Ti:Sa CPA/BBO OPCPA system with a XPW filter in between the two has been developed to produce a broadband high contrast seeder of 10 mJ for the two 10 PetaWatt beamlines of ELI NP infrastructure.

  7. Rapid-melt-mediated recrystallization of ZnO thin films grown at low temperature by using KrF excimer laser irradiation

    NASA Astrophysics Data System (ADS)

    Oh, Min-Suk; Seo, Inseok

    2015-11-01

    ZnO thin films with thickness of 150 nm were grown on ITO/glass (ITO-coated glass) substrates by using the radio-frequency (RF) sputtering technique at 400 °C in an Ar atmosphere. An excimer laser irradiation (ELI) treatment was performed on the surface of ZnO thin films at different excimer laser energy densities of 150, 200, and 250 mJ/cm2 in a N2 atmosphere. The ELI treatment promoted the lateral recystallization of the surface area of the ZnO, resulting in a significant improvement of the crystallinity of the ZnO thin films without substrate damage. As-grown ZnO and ELI-treated ZnO thin films were characterized by using scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray diffraction (XRD). The analyses showed that the ZnO thin film treated with ELI at an excimer laser energy density of 150 mJ/cm2 exhibited the best structural properties.

  8. Laser driven nuclear science and applications: The need of high efficiency, high power and high repetition rate Laser beams

    NASA Astrophysics Data System (ADS)

    Gales, S.

    2015-10-01

    Extreme Light Infrastructure (ELI) is a pan European research initiative selected on the European Strategy Forum on Research Infrastructures Roadmap that aims to close the gap between the existing laboratory-based laser driven research and international facility-grade research centre. The ELI-NP facility, one of the three ELI pillars under construction, placed in Romania and to be operational in 2018, has as core elements a couple of new generation 10 PW laser systems and a narrow bandwidth Compton backscattering gamma source with photon energies up to 19 MeV. ELI-NP will address nuclear photonics, nuclear astrophysics and quantum electrodynamics involving extreme photon fields. Prospective applications of high power laser in nuclear astrophysics, accelerator physics, in particular towards future Accelerator Driven System, as well as in nuclear photonics, for detection and characterization of nuclear material, and for nuclear medicine, will be discussed. Key issues in these research areas will be at reach with significant increase of the repetition rates and of the efficiency at the plug of the high power laser systems as proposed by the ICAN collaboration.

  9. Following electron impact excitations of Rn, Ra, Th, U and Pu single atom L sub-shells ionization cross section calculations by using Lotz's equation

    NASA Astrophysics Data System (ADS)

    Ayinol, M.; Aydeniz, D.

    2016-03-01

    L shell ionization cross section and Li subshells ionization cross sections of Rn, Ra, Th, U, Pu atoms calculated. For each of atoms, ten different electron impact energy values (Eo) are used. Calculations carried out by using Lotz equation in Matlab. First, calculations done for non-relativistic case by using non-relativistic Lotz equation then repeated with relativistic Lotz equation. σL total and σLi(i = 1,2,3) subshells ionisation cross section values obtained for Eo values in the energy range of ELi ELi for each atom. Starting almost from Eo = ELi values of the each sub shell ionization threshold energy, σL total and σLi (i = 1,2,3) are increasing rapidly with Eo. For a fixed Eo = 3.ELi), while Z increases from 86

  10. Exploring the Everyday Life Information Needs, Practices, and Challenges of Emerging Adults with Intellectual Disabilities

    ERIC Educational Resources Information Center

    Hanson-Baldauf, Dana

    2013-01-01

    This dissertation research addresses a gap in the library and information science literature on everyday life information (ELI) needs and experiences of emerging adults with intellectual disabilities (I/DD). Emerging adulthood refers to the period between the late teen years and mid-twenties. Although this is a period of significant change for all…

  11. An Analysis of the Associations between Ambiguity Tolerance and EFL Reading Strategy Awareness

    ERIC Educational Resources Information Center

    Kamran, Saeedeh Karbalaee; Maftoon, Parviz

    2012-01-01

    The current study is an attempt to investigate whether any statistically significant relationship existed between Iranian EFL learners' ambiguity tolerance (AT) and their reading strategy use. To this end, three instruments of Survey of Reading Strategy (Mokhtari & Sheorey, 2002), Second Language Ambiguity Tolerance Scale (Ely, 1995), and a…

  12. Educational Considerations, Spring 1983.

    ERIC Educational Resources Information Center

    Hortin, John A., Ed.; Teague, Fred A., Ed.

    1983-01-01

    Crucial, technologically oriented issues currently facing educators are addressed in the following 11 articles: (1) "The Definition of Educational Technology: An Emerging Stability," by Donald P. Ely; (2) "Media Applications to Instruction: Current Theoretical Considerations," by Gerald M. Torkelson; (3) "The Dilemma of…

  13. Effects of Dextromethamphetamine on Subjective Fatigue.

    DTIC Science & Technology

    1992-08-01

    fright physical and was screened for drug use. APPARATUS Tests were presented using Zenith Z-248 microcomputers equipped as described in a related...0 gelatin capsules (Eli Lilly & Co.). Lactose powder was added to the appropriate dose of d- methamphetamine to fill the capsules. The testing ...significantly less fatigue in the drug group following the administration of methamphetamine . The methamphetamine group reported significantly less

  14. Evolution of the Conditions for Successful Innovation in Remote Networked Schools

    ERIC Educational Resources Information Center

    Hamel, Christine; Turcotte, Sandrine; Laferrière, Thérèse

    2013-01-01

    This paper investigates the presence (or absence) of Ely's (1999) conditions for implementing innovation in a rural context in the province of Quebec (Canada). The innovation, namely the Remote Networked School (RNS) initiative, is designed to bring new technology tools to enrich the learning environment of students and diminish teachers'…

  15. Engaging Developmental Readers in the Social Construction of Meaning.

    ERIC Educational Resources Information Center

    Kaiden, Ellen

    1998-01-01

    Describes an instructional process used in a college developmental reading class (as well as with upper-level classes) that promotes the development of active, engaged readers who constructed meaning through social interaction with fellow classmates. Describes how this strategy was applied to segments of "Night" by Elie Wiesel. (SR)

  16. Chromium Contamination in Army Face Masks.

    DTIC Science & Technology

    1989-01-01

    Piscataway, New Jersey Yoram Cohen, University of California, Los Angeles, California John L. Emmerson, Eli Lilly & Company, Greenfield, Indiana Robert L...Albuquerque, New Mexico Richard B. Setlow, Brookhaven National Laboratory, Upton, New York Torsten N. Wiesel , Rockefeller University, New York, New

  17. God on the Gallows: Reading the Holocaust through Narratives of Redemption

    ERIC Educational Resources Information Center

    Spector, Karen

    2007-01-01

    "Where is God now?" is a question from the Holocaust memoir "Night" by Elie Wiesel and an underlying narrative dilemma for the teachers and most student participants in this qualitative study of three Holocaust units in secondary English classrooms in the Midwestern United States. Using a narrative theory framework, this study explores how…

  18. Literature of the Holocaust: The Imagination after Auschwitz. A Course for Juniors and Seniors. A Teacher's Guide.

    ERIC Educational Resources Information Center

    Klau, Judith R.

    This guide presents a curriculum on the literature of the Holocaust which focuses on the ways in which a particular period in history affected the literature that was created to tell about it. The guide consists of a detailed set of lesson plans for six literary works: a diverse collection of short stories; Elie Wiesel's autobiographical novel,…

  19. Policy Patrons: Philanthropy, Education Reform, and the Politics of Influence. Educational Innovations Series

    ERIC Educational Resources Information Center

    Tompkins-Stange, Megan E.

    2016-01-01

    "Policy Patrons" offers a rare behind-the-scenes view of decision making inside four influential education philanthropies: the Ford Foundation, the W. K. Kellogg Foundation, the Bill & Melinda Gates Foundation, and the Eli and Edythe Broad Foundation. The outcome is an intriguing, thought-provoking look at the impact of current…

  20. The Seeds to Success Modified Field Test: Findings from the Impact and Implementation Studies

    ERIC Educational Resources Information Center

    Boller, Kimberly; Del Grosso, Patricia; Blair, Randall; Jolly, Yumiko; Fortson, Ken; Paulsell, Diane; Lundquist, Eric; Hallgren, Kristin; Kovac, Martha

    2010-01-01

    In 2006, the Bill & Melinda Gates Foundation launched the Early Learning Initiative (ELI) to improve the school readiness of Washington State's children through three main strategies: (1) development of high-quality, community-wide early learning initiatives in two communities; (2) enhancement of statewide systems that support early…

  1. 59. GENERAL VIEW OF HEAD, WHEEL, AND VANE ASSEMBLY OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    59. GENERAL VIEW OF HEAD, WHEEL, AND VANE ASSEMBLY OF ELI WINDMILL ON THE GROUND AT THE STOLL RESIDENCE ABOUT 1-1/2 MILES WEST OF NEBRASKA CITY ON STEAM WAGON ROAD. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  2. 11. Whitney's Armory, Near New Haven, Ct., 1842 Photocopied from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. Whitney's Armory, Near New Haven, Ct., 1842 Photocopied from a woodcut in Henry Howe, Memoirs of the Most Eminent American Mechanics (New York, 1842), p. 124. The best early view of the filing shop and its raceway. See footnote 58. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  3. 75 FR 9333 - Implantation or Injectable Dosage Form New Animal Drugs; Tilmicosin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... Animal Drugs; Tilmicosin AGENCY: Food and Drug Administration, HHS. ACTION: Final rule. SUMMARY: The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect approval of a supplemental new animal drug application (NADA) filed by Elanco Animal Health, A Division of Eli Lilly &...

  4. Perspective view of Wilcox Building (7 North E Street), with ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Perspective view of Wilcox Building (7 North E Street), with Eli Cafe (7 North E Street), the Palace Saloon (11 North E Street), and Fetsche's (15 North E Street) to left of frame, view looking north on E Street - Lakeview Downtown Historic District, E, F & G Streets between Second Street North & First Street South, Lakeview, Lake County, OR

  5. 77 FR 60986 - Environmental Impacts Statements; Notice of Availability

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-05

    ..., Geothermal Leasing on the Humboldt-Toiyabe National Forest, To Facilitate the Development and Production of Geothermal Energy, Ely, Austin, Tonopah and Bridgeport Ranger Districts, NV, Review Period Ends: 11/05/2012... Wind Energy Project, To Approve or Deny an Interconnection Request, Albany County, WY, Comment...

  6. Defense Technical Information Center’s 2010 Student Paper Competition: The Winning Papers

    DTIC Science & Technology

    2010-05-05

    Information and Library Science ; "Intelligence after Intellipedia: Improving the Push Pull Balance with a Social Networking Utility," by Ariane Ben Eli...and Jeremy Hutchins, Pratt Institute, School of Information and Library Science ; and "Information Needs and Behaviors -- NASA Science Program

  7. 63. VIEW FROM BASE AREA INSIDE FRAMEWORK OF STEEL WINDMILL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    63. VIEW FROM BASE AREA INSIDE FRAMEWORK OF STEEL WINDMILL TOWER WITH ELI WINDMILL ON THE GROUND AT STOLL RESIDENCE ABOUT 1-1/2 MILES WEST OF NEBRASKA CITY ON STEAM WAGON ROAD. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  8. 64. VIEW FROM BASE AREA INSIDE FRAMEWORK OF STEEL WINDMILL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    64. VIEW FROM BASE AREA INSIDE FRAMEWORK OF STEEL WINDMILL TOWER WITH ELI WINDMILL ON THE GROUND AT STOLL RESIDENCE ABOUT 1-1/2 MILES WEST OF NEBRASKA CITY ON STEAM WAGON ROAD. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  9. 75 FR 11549 - Determination That PRO-BANTHINE (Propantheline Bromide) Tablets and 14 Other Drug Products Were...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Bldg. 51, rm. 6308, Silver.... Box Equivalent to (EQ) 300 13398, Research mg base/5 mL Triangle Park, NC 27709-3398 NDA 18-207... NDA 20-101 PROZAC (fluoxetine HCl) Eli Lilly and Co., Oral Solution, EQ 20 Lilly Corporate mg base/5...

  10. Grow Your Own School Leaders: A Case Study of Principal Development in Philadelphia Schools

    ERIC Educational Resources Information Center

    Urban Education Collaborative, 2010

    2010-01-01

    In 2004-05, the School District of Philadelphia (SDP) began a groundbreaking partnership with the Eli Broad Foundation to develop the Academy for Leadership in Philadelphia Schools (ALPS), one of several Broad-funded, alternative principal development programs initiated across the country. The ALPS effort was designed to respond to two challenges:…

  11. TESL Reporter, Vol. 6, No. 3.

    ERIC Educational Resources Information Center

    Pack, Alice C., Ed.

    The following articles on teaching English as a second language are included in this issue: (1) "ELI Tutorial" (about the tutorial program at the English Language Institute of the Church College of Hawaii) by Michael E. Foley; (2) "English-TESL Programs at the Church College of Hawaii" by Jay Fox; (3) "Developmental Speech…

  12. Evaluation of Small System Filtration Technologies for the Treatment of Color, Disinfection ByProducts and Microbiological Contaminants in Surface Water

    EPA Science Inventory

    The U.S. Environmental Protection Agency (EPA) National Risk Management Research Laboratory (NRMRL) evaluated various filtration systems at the EPA T&E Facility in Cincinnati, Ohio and at a field site in Ely, Minnesota (MN) in collaboration with the Minnesota Department of Health...

  13. Development of a 670 GHz Extended Interaction Klystron Power Amplifier

    DTIC Science & Technology

    2011-03-01

    th of which wi ment of EIK’ ely on lithogr ion circuits w o minimize los s that only ce lithographica ost obvious pper parts can nal distortion...ibution Unlimited interpreted as r epartment of De ts, where the R 000nm; in our ctivity of app pper , consiste tal dissipation of RF dissipa ll be largest

  14. Promoting Early Literacy Skills within Daily Activities and Routines in Preschool Classrooms

    ERIC Educational Resources Information Center

    Chandler, Lynette K.; Young, Robin Miller; Nylander, Donna; Shields, LuAnn; Ash, JoAnne; Bauman, Becky; Butts, Jill; Black, Kristine; Geraghty, Peggy; Hafer, Megan; Lay, Angie; Mitera, Brandie; Richardson, Debra; Steffen, Kara; Summers, Debra

    2008-01-01

    Many teachers and other service providers struggle with trying to address the many skills that are important for young children to acquire during the preschool years. Early Literacy Initiative project (Project ELI) is a comprehensive, two-tiered, early language and literacy intervention model that includes activities for all children as well as…

  15. 8. Town of Hamden, 1852. Photocopied from a photostatic detail ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. Town of Hamden, 1852. Photocopied from a photostatic detail in the collection of the Hamden Historical Society, Hamden, Connecticut. From R. Whiteford, 'Map of the County of New Haven, Connecticut' (New Haven, 1852). Shown are 'Witney's sic Armory,' 'Whitney's Marine Clock Factory,' and 'Whitney' s Pistol Factory.' - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  16. 26. Site plan of Lake Whitney; detail of original engineering ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. Site plan of Lake Whitney; detail of original engineering drawing, 1856 Photocopied from map drawn and surveyed by Nelson J. Welton, C.E., 'Contemplated Waterworks at Whitneyville, 1856,' unaccessioned New Haven Water Company Papers, collection of NHCHSL. Shows 'Whitney's Upper Armory,' 'Clock Shop,' 'E. Whitney's Lower Armory.' - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  17. Challenging the Status Quo

    ERIC Educational Resources Information Center

    Maxwell, Lesli A.

    2006-01-01

    Steeped in a distinctive view of leadership, graduates of the Broad Superintendents Academy have landed some of public education's top jobs. In this article, the author features the Broad Superintendents Academy, a program established by Eli Broad's Foundation which spends roughly $45,000 to train each of the business executives, military…

  18. Innovations in Corporate Career Centers--Special Issue.

    ERIC Educational Resources Information Center

    Patch, Ken, Ed.

    2000-01-01

    Nine articles describe corporate career centers at Advanced Macro Devices, Sun Microsystems, Tellabs, DaimlerChrysler, Eli Lilly, Toronto Dominion Bank, Motorola, Honeywell, and Dow Corning. Other articles give an historical overview and address virtual career centers, talent management, and future directions. (SK)

  19. 78 FR 54674 - Notice of Intent To Prepare an Environmental Impact Statement for the Proposed Gold Rock Mine...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-05

    ...: 14X5017] Notice of Intent To Prepare an Environmental Impact Statement for the Proposed Gold Rock Mine...) Egan Field Office, Ely, Nevada, intends to prepare an Environmental Impact Statement (EIS) and by this... ] associated ponds, process facility, and refinery; a mill; a carbon-in- leach plant; waste rock dumps;...

  20. 40 CFR 80.215 - What is the scope of the geographic phase-in program?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the geographic phase-in program: North Dakota, Montana, Idaho, Wyoming, Utah, Colorado, New Mexico... River Haakon Harding Jackson Jones Lawrence Meade Mellette Pennington Perkins Shannon Stanley Todd... Indian reservations follows: Burns Paiute, Cheyenne River, Colville, Duck Valley, Ely Colony, Fort...

  1. 40 CFR 80.215 - What is the scope of the geographic phase-in program?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the geographic phase-in program: North Dakota, Montana, Idaho, Wyoming, Utah, Colorado, New Mexico... River Haakon Harding Jackson Jones Lawrence Meade Mellette Pennington Perkins Shannon Stanley Todd... Indian reservations follows: Burns Paiute, Cheyenne River, Colville, Duck Valley, Ely Colony, Fort...

  2. 40 CFR 80.215 - What is the scope of the geographic phase-in program?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the geographic phase-in program: North Dakota, Montana, Idaho, Wyoming, Utah, Colorado, New Mexico... River Haakon Harding Jackson Jones Lawrence Meade Mellette Pennington Perkins Shannon Stanley Todd... Indian reservations follows: Burns Paiute, Cheyenne River, Colville, Duck Valley, Ely Colony, Fort...

  3. Acoustic Emission Determination of Deformation Mechanisms Leading to Failure of Naval Alloys. Volume 2

    DTIC Science & Technology

    1983-05-01

    Emission Laser Beam Interferometer HY80 , 100, 130 Steels Mechanical Deformation Nondestructive Evaluation 2. ABSTRACT (Conetnue an rovere eli if necoo y...publication, J. Applied Phys.). 43. A. Peterlin, B.B. Djordjvic, J.C. Murphy, R.E. Green, "Acoustic Emission During Craze Forma- tion in Polymers

  4. Special cancer microenvironment in human colonic cancer: Concept of cancer microenvironment formed by peritoneal invasion (CMPI) and implication of subperitoneal fibroblast in cancer progression.

    PubMed

    Kojima, Motohiro; Ochiai, Atsushi

    2016-01-27

    Clinical outcomes of colorectal cancer are influenced not by tumor size, but by spread into the bowel wall. Although assessment of serosal involvement is an important pathological feature for classification of colon cancer, its diagnostic consistency has been questioned. Using elastic staining, we assessed elastic laminal invasion (ELI) for more objective stratification of deep tumor invasion around the peritoneal surface. In addition, pathological characteristic features of marked tumor budding, fibrosis, and macrophage infiltration in the tumor area with ELI was elucidated. This characteristic tumor area was termed cancer microenvironment formed by peritoneal elastic laminal invasion (CMPI). We elucidated histoanatomical layer-dependent heterogeneity of fibroblast in colonic tissue. Furthermore, subperitoneal fibroblasts (SPFs) play a crucial role in tumor progression and metastasis in CMPI. Our ELI and CMPI concept contributes not only to objective pathological diagnosis, but also sheds light on biological research of special cancer microenvironments detectable in human colorectal cancers. Herein, we describe the diagnostic utility of ELI and morphological alteration in advanced colorectal cancers to determine the phenomenon that occurs when tumors invade around the peritoneal surface. Next, biological research of CMPI is reviewed to stress the importance of pathological research to establish new biological concepts.

  5. Spread of tumor microenvironment contributes to colonic obstruction through subperitoneal fibroblast activation in colon cancer

    PubMed Central

    Yokota, Mitsuru; Kojima, Motohiro; Higuchi, Youichi; Nishizawa, Yuji; Kobayashi, Akihiro; Ito, Masaaki; Saito, Norio; Ochiai, Atsushi

    2015-01-01

    We evaluated the influence of the cancer microenvironment formed by peritoneal invasion (CMPI) on clinical findings in colon cancer patients. In addition to the association with poor prognosis, we discovered a relationship with bowel obstruction. Detailed analysis revealed that clinical findings related to bowel obstruction occurred more frequently in patients with an elevated type tumor, which had peritoneal elastic laminal elevation to the tumor surface, compared to those with non-elevated type tumors among those with elastic laminal invasion (ELI). Lateral tumor spread and increase of tumor annularity rate in ELI-positive elevated type cases suggested the morphological progression from ELI-positive non-elevated type to elevated type. In addition, α-smooth muscle actin expression was the highest in ELI-positive elevated type, and prominent expressions were found not only in the deep tumor area but also in the shallow tumor area. Furthermore, contraction assays revealed the robust contractile ability of subperitoneal fibroblasts stimulated by cancer cell-conditioned medium. Our findings suggest that CMPI spread into the luminal side of the colonic wall along with tumor progression, which caused bowel obstruction through the activation of subperitoneal fibroblasts. However, although the clinical outcome was not different between the two types, the clinical findings were affected by the spread of CMPI. We are the first to explore how the alteration of the tumor-promoting microenvironment, along with tumor progression, contributes to the development of clinical findings. PMID:25613547

  6. Special cancer microenvironment in human colonic cancer: Concept of cancer microenvironment formed by peritoneal invasion (CMPI) and implication of subperitoneal fibroblast in cancer progression

    PubMed Central

    Ochiai, Atsushi

    2016-01-01

    Clinical outcomes of colorectal cancer are influenced not by tumor size, but by spread into the bowel wall. Although assessment of serosal involvement is an important pathological feature for classification of colon cancer, its diagnostic consistency has been questioned. Using elastic staining, we assessed elastic laminal invasion (ELI) for more objective stratification of deep tumor invasion around the peritoneal surface. In addition, pathological characteristic features of marked tumor budding, fibrosis, and macrophage infiltration in the tumor area with ELI was elucidated. This characteristic tumor area was termed cancer microenvironment formed by peritoneal elastic laminal invasion (CMPI). We elucidated histoanatomical layer‐dependent heterogeneity of fibroblast in colonic tissue. Furthermore, subperitoneal fibroblasts (SPFs) play a crucial role in tumor progression and metastasis in CMPI. Our ELI and CMPI concept contributes not only to objective pathological diagnosis, but also sheds light on biological research of special cancer microenvironments detectable in human colorectal cancers. Herein, we describe the diagnostic utility of ELI and morphological alteration in advanced colorectal cancers to determine the phenomenon that occurs when tumors invade around the peritoneal surface. Next, biological research of CMPI is reviewed to stress the importance of pathological research to establish new biological concepts. PMID:26816328

  7. Computer Chips and Paper Clips. Technology and Women's Employment. Volume II. Case Studies and Policy Perspectives.

    ERIC Educational Resources Information Center

    Hartmann, Heidi I., Ed.; And Others

    This volume contains 12 papers commissioned by the Panel on Technology and Women's Employment. "Technology, Women, and Work: Policy Perspectives" (Eli Ginzberg) is an overview that provides a context for the volume. The four case studies in Part II describe the impact of information technology in the insurance industry, among bookkeepers, among…

  8. Child Abuse and Neglect: The Proceedings of an Interdisciplinary Workshop on Child Abuse.

    ERIC Educational Resources Information Center

    Department of Health, Education, and Welfare, Washington, DC.

    Proceedings of a workshop on the need to establish a close working relationship between the medical, legal, and social work professions in the management of child abuse is presented. An introduction by Frank Beal is followed by welcoming remarks by Pennsylvania Governor Milton Shapp. Speeches by Elizabeth Davoren, Eli Newberger, and Vincent…

  9. 75 FR 54019 - New Animal Drugs for Use in Animal Feed; Ractopamine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-03

    ... Administration 21 CFR Part 558 [Docket No. FDA-2010-N-0002] New Animal Drugs for Use in Animal Feed; Ractopamine... (FDA) is amending the animal drug regulations to reflect approval of two supplemental new animal drug applications (NADAs) filed by Elanco Animal Health, A Division of Eli Lilly & Co. The supplemental...

  10. 75 FR 5887 - New Animal Drugs for Use in Animal Feeds; Ractopamine; Monensin

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... HUMAN SERVICES Food and Drug Administration 21 CFR Part 558 New Animal Drugs for Use in Animal Feeds... Drug Administration (FDA) is amending the animal drug regulations to reflect approval of an original new animal drug application (NADA) filed by Elanco Animal Health, A Division of Eli Lilly & Co....

  11. Found in Translations: Using Multiple Versions of Translated Text for Close Analysis of Language

    ERIC Educational Resources Information Center

    Larochelle, Paul

    2011-01-01

    To prepare students for the rigorous tasks of the unseen written commentary and the oral commentary on an extract from a studied text, the author has had to explore new ways of engaging students in attending to the subtleties of language. Inspired by a classroom mishap regarding translations of Elie Wiesel's "Night," the author uses multiple text…

  12. ECO LOGIC INTERNATIONAL GAS-PHASE CHEMICAL REDUCTION PROCESS - THE REACTOR SYSTEM - APPLICATIONS ANALYSIS REPORT

    EPA Science Inventory

    The ELI Eco Logic International Inc. (Eco Logic) process thermally separates organics, then chemically reduces them in a hydrogen atmosphere, converting them to a reformed gas that consists of light hydrocarbons and water. A scrubber treats the reformed gas to remove hydrogen chl...

  13. Developing Reading and Writing Skills of Learners' from Arabic-Speaking Backgrounds

    ERIC Educational Resources Information Center

    Fuqua, Jason

    2015-01-01

    The number of native Arabic-speaking students coming to America to study English in university programs has grown over the past few years, and continues to be substantial. It has also been noticed by the English Language Institute (ELI) at Sam Houston State University (SHSU) that these students often struggle more with reading activities in class,…

  14. Ethical Leadership: What Does It Look like?

    ERIC Educational Resources Information Center

    Schulte, Laura

    2009-01-01

    This article focuses on the development and validation of the Ethical Leadership Index (ELI). The development and validation processes included: adopting a framework; developing items; providing evidence of content validity; conducting a pilot study; and analyzing data to provide evidence of construct validity and reliability estimates. Five…

  15. Phonological Awareness and Word Recognition in Reading by Children with Autism

    ERIC Educational Resources Information Center

    Gabig, Cheryl Smith

    2010-01-01

    This research examined phonological awareness (PA) and single word reading in 14 school-age children with autism and 10 age-matched, typically developing (TD) children between 5-7 years. Two measures of PA, an elision task (ELI) and a sound blending task (BLW), were given along with two measures of single word reading, word identification for real…

  16. Drug Advertising and the FDA.

    ERIC Educational Resources Information Center

    Levesque, Cynthia

    With increases in consumer focused advertising for prescription drugs, the Federal Drug Administration has renewed efforts to protect the public from false advertising. In 1982, it charged that the press kits Eli Lilly and Company distributed to reporters on its new antiarthritis drug, Oraflex, misrepresented the product. It recommended that Lilly…

  17. Draft Environmental Impact Statement. MX Deployment Area Selection & Land Withdrawal/Acquisition. Volume I. Program Overview.

    DTIC Science & Technology

    1980-12-01

    Dalhart , Texas ; and...vicinities of Dalhart , Texas , and Clovis, New Mexico. If "split-basing" is selected, deployment would occur in portions of Nevada, Utah, Texas , and New Mexico...communities: " Pioche, Nevada " Ely, Nevada o Eureka, Nevada " Tonopah, Nevada " Delta, I tah " Milford, Utah " Dalhart , Texas " Hereford, Texas

  18. ECO LOGIC INTERNATIONAL GAS-PHASE CHEMICAL REDUCTION PROCESS - THE THERMAL DESORPTION UNIT - APPLICATIONS ANALYSIS REPORT

    EPA Science Inventory

    ELI ECO Logic International, Inc.'s Thermal Desorption Unit (TDU) is specifically designed for use with Eco Logic's Gas Phase Chemical Reduction Process. The technology uses an externally heated bath of molten tin in a hydrogen atmosphere to desorb hazardous organic compounds fro...

  19. The Broad Way

    ERIC Educational Resources Information Center

    Butler, Kevin

    2008-01-01

    In the world of corporate philanthropy, there are those who give to educational causes, and this article describes one such philanthropist, Eli Broad, who shares his take on schools in America. Broad is in a category unto himself not only because of the amount of money he has given--more than $280 million since 1999--but also for his unique…

  20. Appreciating an Old Favorite: Sousa's All-Time Hit

    ERIC Educational Resources Information Center

    Van Outryve, Karen

    2006-01-01

    In this article, the author presents John Philip Sousa's all time hit, "The Stars and Stripes Forever". It is one of the most recognizable pieces of American music. Wherever John Philip Sousa and his band appeared, this march was likely to be played. According to American poet and educator Eli Siegel (1902-78), who first articulated the…

  1. Trendspotting 2011

    ERIC Educational Resources Information Center

    Thomas, Lisa Carlucci

    2011-01-01

    In this article, the author discusses Connecticut Library Consortium's (CLC) recently held fifth annual Trendspotting symposium, "E-books: Collections at the Crossroads." She was pleased to work with CLC to develop a cutting-edge program of dynamic, thought-provoking speakers and presentations, including an outstanding keynote by Eli Neiburger on…

  2. Oxidation of methionine 216 in sheep and elk prion protein is highly dependent upon the amino acid at position 218 but is not important for prion propagation

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We developed a sensitive mass spectrometry-based method of quantitating the prions present in elk and sheep. Calibration curves relating the area ratios of the selected analyte peptides and their homologous stable isotope labeled internal standards were prepared. This method was compared to the ELIS...

  3. A Mouse Model for in Vivo Detection and Disruption of TGF-Beta Signaling in Breast Cancer Metastasis

    DTIC Science & Technology

    2009-09-01

    inhibitors 2-(3-(6-methylpyridin-2-yl)-1H- pyrazol -4-yl)-1,5-naphthyri- dine (EMD Biosciences catalog number 616452) and (3-(pyridin-2-yl)-4-(4...quinonyl))-1H- pyrazole (LY364947, EMD catalog number 616451) in DMSO for in vitro experiments. We dissolved compound LY2109761 (Eli Lilly) at a concentration

  4. Guiding School Change: The Role and Work of Change Agents. The Series on School Reform.

    ERIC Educational Resources Information Center

    Rust, Frances O'Connell, Ed.; Freidus, Helen, Ed.

    This book examines facilitators of change, as viewed by the change agents themselves. It highlights their role and how they can be prepared and supported. In chapter 1, Frances O'Connell Rust, Margot Ely, Maris H. Krasnow, and LaMar P. Miller report on the successful professional development of early elementary teachers in New York City. In…

  5. 61. DETAIL OF HEAD, VANE STEM, VANE HINGE, AND WHEEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    61. DETAIL OF HEAD, VANE STEM, VANE HINGE, AND WHEEL OF AN ELI WINDMILL ON THE GROUND AT THE STOLL RESIDENCE ABOUT 1-1/2 MILES WEST OF NEBRASKA CITY ON STEAM WAGON ROAD. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  6. Supporting Low-Achieving EFL Learners: Expectations, Procedure and Significance of Remedial Sessions at a Saudi University

    ERIC Educational Resources Information Center

    Alghamdi, Fatimah M. A.; Siddiqui, Ozma

    2016-01-01

    This study reports on and investigates an institutionalized remedial approach held by an English language institute (ELI) at a Saudi University in order to support foundation year struggling students who often achieve low grades or fail to pass a certain level of the English language program. The study utilizes semi-structured interviews to…

  7. Academic Ambitions and Library Development: The American Bureau of Industrial Research and the State Historical Society of Wisconsin, 1904-18. Occasional Paper Number 159.

    ERIC Educational Resources Information Center

    Colson, John Calvin

    Intended to contribute to a better understanding of research library development in the United States, this report describes the history of the development of the library of the State Historical Society of Wisconsin from 1904 to 1918. It is based on records of the relationships between three principals--John R. Commons and Richard T. Ely (members…

  8. Lenticular stretch structures in eastern Nevada - possible trapping mechanism in supposed graben

    SciTech Connect

    Walker, C.T.; Dennis, J.G.; Lumsden, W.W.

    1986-04-01

    Eastern Nevada is widely recognized as a region of tectonic extension. The dominant structures are generally agreed to be low-dipping, younger over older faults and steeper listric faults that are responsible for the basins (grabens) and ranges (horsts). In the Schell Creek-Duck Creek Range, east of Ely, and in the White Pine Range, southwest of Ely, small lenticular structures bounded by tectonic discontinuities can be clearly seen in the field. These lenticular units, or stretch structures, range in length from a few meters to more than 200 m. All lenticular stretch structures that can be clearly seen in the field are stratigraphically restricted; the stretched formations are the Eureka Quartzite, the Pilot Shale, the Joana Limestone, and the Chainman Shale. Still larger stretch structures, which may include several formations, are inferred, and the authors suggest that extension has created lenticular structures at all scales. The Duck Creek and Schell Creek Ranges east of Ely consist mostly of Devonian and older rocks. They are separated by a topographically lower area containing mostly Mississippian and Pennsylvanian rocks. This structure, which separates the ranges, has been referred to as a graben, but field evidence suggests that it is a large-scale lenticular stretch structure. Unlike a true graben, the structure does not extend downward. For example, in several places within the supposed graben, Cambrian and Ordovician rocks project through a cover of Carboniferous Chainman Shale and Ely Limestone, suggesting the Chainman-Ely is a thin sheet underlain by Cambrian-Ordovician rocks. Accordingly, they suggest that extension in the Duck Creek-Schell Creek Ranges stretched the formations into lenticular bodies. Between the Duck Creek and Schell Creek Ranges, the Cambrian-Ordovician is attenuated, and the resulting tectonic depression is occupied by a lenticular mass of Carboniferous rocks.

  9. Fatigue Life of Titanium Alloys Fabricated by Additive Layer Manufacturing Techniques for Dental Implants

    NASA Astrophysics Data System (ADS)

    Chan, Kwai S.; Koike, Marie; Mason, Robert L.; Okabe, Toru

    2013-02-01

    Additive layer deposition techniques such as electron beam melting (EBM) and laser beam melting (LBM) have been utilized to fabricate rectangular plates of Ti-6Al-4V with extra low interstitial (ELI) contents. The layer-by-layer deposition techniques resulted in plates that have different surface finishes which can impact significantly on the fatigue life by providing potential sites for fatigue cracks to initiate. The fatigue life of Ti-6Al-4V ELI alloys fabricated by EBM and LBM deposition techniques was investigated by three-point testing of rectangular beams of as-fabricated and electro-discharge machined surfaces under stress-controlled conditions at 10 Hz until complete fracture. Fatigue life tests were also performed on rolled plates of Ti-6Al-4V ELI, regular Ti-6Al-4V, and CP Ti as controls. Fatigue surfaces were characterized by scanning electron microscopy to identify the crack initiation site in the various types of specimen surfaces. The fatigue life data were analyzed statistically using both analysis of variance techniques and the Kaplan-Meier survival analysis method with the Gehan-Breslow test. The results indicate that the LBM Ti-6Al-4V ELI material exhibits a longer fatigue life than the EBM counterpart and CP Ti, but a shorter fatigue life compared to rolled Ti-6Al-4V ELI. The difference in the fatigue life behavior may be largely attributed to the presence of rough surface features that act as fatigue crack initiation sites in the EBM material.

  10. Pre-transplant assessment of CMV-specific immune response by Elispot assay in kidney transplant recipients.

    PubMed

    Rittà, Massimo; Costa, Cristina; Sidoti, Francesca; Ballocco, Cinzia; Ranghino, Andrea; Messina, Maria; Biancone, Luigi; Cavallo, Rossana

    2015-07-01

    Cytomegalovirus (CMV) primary infection or re-activation in solid organ transplant (SOT) recipients is associated with increased morbidity and mortality, with patients with IgG-CMV D+/R- sero-matching at greater risk. The impact of pre-transplant CMV-specific host cellular immunity on the long-term risk of CMV replication in kidney transplants (KT) was prospectively evaluated in eighty patients by CMV-EliSpot assay. The study population included 54 male and 26 female recipients, with CMV-IgG distribution: 60 D+/R+, 11 D-/R+, 7 D+/R-, 2 D-/R-. At pre-transplantation, 49 KT (61.3%) were CMV-responders by EliSpot. At 3-month follow up, 16 (32.7%) out of 49 CMV-responders showed CMV blood infection, compared to 8 (25.8%) out of 31 non-responders. No further episode of CMV viraemia was reported in the responder group, in comparison to 15 out 31 non-responders (48.4%) showing at least one episode of CMV-DNAemia at 12-month follow-up. Baseline CMV-IgG serology showed a strong correlation with EliSpot determinations; KT recipients exhibiting at least one episode of CMV viraemia at 12-month follow-up showed lower baseline CMV-EliSpot values than those without signs of CMV replication. The study suggests that monitoring CMV-specific T-cell responses at pre-transplantation by EliSpot assay may be useful for predicting the post-transplantation risk of CMV infection and reactivation.

  11. Investigation of the fracture mechanism in Ti-5Al-2.5Sn at cryogenic temperatures

    NASA Technical Reports Server (NTRS)

    Vanstone, R. H.; Low, J. R., Jr.; Shannon, J. L., Jr.

    1977-01-01

    The influence of microstructure on the fracture mechanism and plane-strain fracture toughness of Ti-5Al-2.5Sn was studied through the use of fractography and metallographic sectioning techniques. One-inch thick plates of extra low interstitial (ELI) and normal interstitial Ti-5Al-2.5Sn were mill annealed at 815 C followed by either air or furnace cooling. These variations in composition and cooling rate resulted in differences in the volume fraction and internal structure of the iron-stabilized phase, and in the crystallographic texture and ordering of the alpha matrix. The tensile properties of these plates were determined at 20 K, 77 K, and 295 K. The air-cooled ELI plate was the toughest material evaluated.

  12. Control-Theoretic Formulation of Operating Systems Resource Management Policies.

    DTIC Science & Technology

    1978-05-01

    shock. A linearized and time invariant form of the above equation is the well known ARMA(p, q ) model (see Appendix A for details on ARMA models) z(0) = w...Name Chi-Sq Type 1. COMP2.G63 158 24.8 85.0 0.000 FORTRAN Provram 2. ECL.B1 81 11.2 18. q 0.241 ELI Prcgrm 3. ECL.B2 260 74.7 379.9 0.006 ELI Program 4...RST N’S5E E L3E3E- CPUJ DEM. E O-AVF-, Q ; C-1 CPU EEkVIr Z 10 0! *41 &POTS. M. 4072 . PN ’% 7.l.0 . .. T2.L 234 .p;TS. MEA -AM -. ~ i C.,~ .’ * 22.0 8

  13. Stress Corrosion Cracking and Fatigue Crack Growth Studies Pertinent to Spacecraft and Booster Pressure Vessels

    NASA Technical Reports Server (NTRS)

    Hall, L. R.; Finger, R. W.

    1972-01-01

    This experimental program was divided into two parts. The first part evaluated stress corrosion cracking in 2219-T87 aluminum and 5Al-2.5Sn (ELI) titanium alloy plate and weld metal. Both uniform height double cantilever beam and surface flawed specimens were tested in environments normally encountered during the fabrication and operation of pressure vessels in spacecraft and booster systems. The second part studied compatibility of material-environment combinations suitable for high energy upper stage propulsion systems. Surface flawed specimens having thicknesses representative of minimum gage fuel and oxidizer tanks were tested. Titanium alloys 5Al-2.5Sn (ELI), 6Al-4V annealed, and 6Al-4V STA were tested in both liquid and gaseous methane. Aluminum alloy 2219 in the T87 and T6E46 condition was tested in fluorine, a fluorine-oxygen mixture, and methane. Results were evaluated using modified linear elastic fracture mechanics parameters.

  14. Modeling Nonlinear Acoustical Blast Waves Outdoors: A Research Summary

    DTIC Science & Technology

    1991-09-01

    Porous Surfaces. 5 David Gottlieb and Eli Turkel, "Dissipative Two-Four Methods for Time Dependent Problems," Mathematical Comnputation, No. 30 (1976...or structure factor, which Attenborough relates to the tortuosity. The local reaction assumption is inhereptly built into this model of the porous...k Waves in the Atmosphere," Journal of the Acoustical Socidy of America, No. 74 (1983). pp 1514-1517. David T. Blackstone., "Nonlinear Acoustics

  15. Prediction Markets as a Way to Manage Acquisition Programs

    DTIC Science & Technology

    2011-06-01

    social responsibility (Corporate Executive Board, 2006). Table 2. Experiences of Early Adopters (From Malone, 2004 & Kiviat, 2004) Application...the likelihood that an event will occur and on a specific date. 14 Social Responsibility BP BP set up an internal market to reduce the oil...than official forecast. Product Development Eli Lilly NA NA NA NA NA General Forecasting Google NA NA NA NA NA Social Responsibility BP

  16. Faces of the Recovery Act: 1366 Technologies

    ScienceCinema

    Sachs, Ely; Mierlo, Frank van; Obama, Barack

    2016-07-12

    LEXINGTON, MA - At 1366 Technologies, Ely Sachs and Frank van Mierlo are using ARPA-E Recovery Act funding to dramatically reduce the costs of solar panel production. To read more about the project: http://arpa-e.energy.gov/FundedProjects.aspx#1366 To see more projects funded by the Recovery Act through ARPA-E: http://arpa-e.energy.gov/FundedProjects.aspx

  17. Institute for Defense Analyses. Annual Report 2004

    DTIC Science & Technology

    2004-01-01

    sensor mounted on a Meerkat blast-protected vehicle. A great many of the IEDs encountered in Iraq are based on standard artillery projectiles equipped...physics, nanotechnology, and molecular biology – which have consumed an increasing share of global R&D expenditures in recent years. Through...Chief Informatics Offi cer, and Director, Bioinformatics and Computational Biology Programs, The Eli and Edythe L. Broad Institute, MIT & Harvard

  18. WSTIAC Newsletter. Volume 6, Number 2, Spring 2006

    DTIC Science & Technology

    2006-01-01

    past or through the storming and the norming phases in Task Functions Pe rs on al R el at io ns Model for Group Development Adapted from: Tuckman , B...exceptions) and some are a lot older tracing themselves back to Henry Ford or Eli Whitney (or even earlier). Having said that, there are two models ...that currently align them- selves with L6σ and both of these have their own structured methods of thinking. They are the DMAIC model (Define- Measure

  19. Perceptual Fidelity for Digital Color Imagery

    DTIC Science & Technology

    1996-12-01

    AFIT/DS/ENG/96-14 PERCEPTUAL FIDELITY FOR DIGITAL COLOR IMAGERY DISSERTATION Curtis Eli Martin Captain, USAF AFIT/DS/ENG/96-14 Approved for public...SIGNIFICANT NUMBER OF COLOR PAGES WHICH DO NOT REPRODUCE LEGIBLY ON BLACK AND WHITE MICROFICHE. The views expressed in this dissertation are those of the...FOR DIGITAL COLOR IMAGERY DISSERTATION Presented to the Faculty of the Graduate School of Engineering of the Air Force Institute of Technology Air

  20. Cooper River Rediversion Project. Lake Moultrie and Santee River, South Carolina. Intake and Tailrace Canals. Appendix A. Boring Logs and Laboratory Test.

    DTIC Science & Technology

    1976-06-01

    r ivdiversion Charleston District - CLAS’StrIAT.ON F COR bOX OR $tARKS ECOV SAMPLE fl.ls,,, . . . . / . ER) NC,*O .[ tU , _ Limestone, dark gray...OR REMARKS FL AICN DE PT, EEND L-t’ ECOv - SAAMPLE T),,~,,,~,. .dp,h .1 ELY NO ’IP.f d e f - g Blow/Ft I M-Siltv Fine and Med. Sand 16 I Ylow mc16.3% 79

  1. Molecular Design and Synthesis of New Noncrystalline Solids

    DTIC Science & Technology

    1981-06-01

    P. Luongo, Thermochimica Acta, S, 141 (1974). 3. Lina Ben-Dor, Eli Fischbein, Israel Feliner and Zvi Kalman, J. Flectrchcm. Soc.: Solid State Science...hexaborides. Increased participation 1121 VVol-II’r fi,Nmn1i itI , i PHY~SICAL. RElVIE\\\\’ L.ETTElRS 29SI ’ I NIIHi 1980 of di electrons in the Y alloy0 may

  2. Fundamentals of neurobiology.

    PubMed

    Greg Hall, D

    2011-01-01

    Session 1 of the 2010 STP/IFSTP Joint Symposium on Toxicologic Neuropathology, titled "Fundamentals of Neurobiology," was organized to provide a foundation for subsequent sessions by presenting essential elements of neuroanatomy and nervous system function. A brief introduction to the session titled "Introduction to Correlative Neurobiology" was provided by Dr. Greg Hall (Eli Lilly and Company, Indianapolis, IN). Correlative neurobiology refers to considerations of the relationships between the highly organized and compartmentalized structure of nervous tissues and the functioning within this system.

  3. Breaking the Azimuthal Symmetry-Jumping Off-aAis or Staying Away from the Axis?

    DTIC Science & Technology

    2002-06-24

    Staying Away from the Axis? Eli Sarid , 1 Catalin Teodorescu 2 , Phil Marcus 3 and Joel Fajans Physics Department, University of California, Berkeley...has a shift D firom the axis ( D might be zero). The background has radius of rb (which might be as large as the wall radius, but can also be smaller...results of both the experiments and the simulations, but they are not crucial to the emerging physical picture. With these assumptions, only D and rb remain

  4. 23. NORTHEAST TO CIRCA 1875 POWER SHEAR, PUNCH, AND RIVETING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. NORTHEAST TO CIRCA 1875 POWER SHEAR, PUNCH, AND RIVETING MACHINE SET UP TO DEMONSTRATE USE IN RIVETING COMPONENTS OF WHEEL ARMS FOR ELI WINDMILLS. HISTORIC DEBRIS FROM PUNCHING WORK IS VISIBLE BENEATH THE MACHINE IN THE OPERATOR'S PIT.' ON THE LEFT IS A U-SHAPED LOVEJOY FIELD PUNCH FOR USE IN INSTALLING STEEL WINDMILL/TOWER COMPONENTS. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  5. Accuracy of three different fecal calprotectin tests in the diagnosis of inflammatory bowel disease

    PubMed Central

    Jang, Hui Won; Kim, Hyun Sook; Park, Soo Jung; Hong, Sung Pil; Kim, Tae Il; Kim, Won Ho

    2016-01-01

    Background/Aims Several studies have found that the measurement of fecal calprotectin is useful for the early diagnosis of inflammatory bowel disease (IBD). We compared the effectiveness of three different fecal calprotectin kits for initial diagnosis in patients with suspected IBD. Methods We enrolled 31 patients with IBD (18 Crohn's disease [CD], 11 ulcerative colitis [UC], and two intestinal Behçet's disease), five with irritable bowel syndrome (IBS), and five with other colitis (four infectious colitis and one intestinal tuberculosis). Diagnosis was based on clinical, laboratory, and endoscopic examinations. Fecal samples were obtained at the first diagnosis and calprotectin levels were measured using three different kits (Quantum Blue® Calprotectin, EliA™ Calprotectin, and RIDASCREEN® Calprotectin). Results The overall accuracy for differentiating IBD from IBS or other colitis was 94% and 91%, respectively, for Quantum Blue® (cutoff, 50 µg/g); 92% and 89%, respectively, for EliA™ (cutoff, 50 µg/g); and 82% and 76%, respectively, for RIDASCREEN® (cutoff, 50 µg/g). In patients with CD, the results of Quantum Blue® Calprotectin and EliA™ Calprotectin correlated significantly with levels of the Crohn's disease activity index (Spearman's rank correlation coefficient, r=0.66 and r=0.49, respectively). In patients with UC, the results of EliA™ Calprotectin correlated significantly with the Mayo score (r=0.70). Conclusions Fecal calprotectin measurement is useful for the identification of IBD. The overall accuracies of the three fecal calprotectin kits are comparable. PMID:27799881

  6. 13. Site plan, 1900 Photocopied from a blueprint, 'Appraisal of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Site plan, 1900 Photocopied from a blueprint, 'Appraisal of Water Power and Real Estate at Whitneyville, 1900,' New Haven Water Company, 100 Crown Street, New Haven, Connecticut. Shows the Whitney Arms Company as it existed for much of the period 1860-1904. Compare with photo CT-2-10. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  7. Information Processing and Collective Behavior in a Model Neuronal System

    DTIC Science & Technology

    2014-03-28

    at times weekly) telecoms with them and Eli Shlizerman at the University of Washington. In summary, we were happy to work with many groups within...states cause high intracellular calcium concentrations, which could trigger transcription of clock genes . The model also predicts that circadian...phenotypes of mutations or knockdown of clock genes as well as the time courses and relative expression of clock transcripts and proteins. Using this model

  8. Prospects for studying vacuum polarisation using dipole and synchrotron radiation

    NASA Astrophysics Data System (ADS)

    Ilderton, Anton; Marklund, Mattias

    2016-04-01

    > The measurement of vacuum polarisation effects, in particular vacuum birefringence, using combined optical and X-ray laser pulses are now actively pursued. Here we briefly examine the feasibility of two alternative set-ups. The first utilises an alternative target, namely a converging dipole pulse, and the second uses an alternative probe, namely the synchrotron-like emission from highly energetic particles, themselves interacting with a laser pulse. The latter set-up has been proposed for experiments at ELI-NP.

  9. Photoneutron Reactions in Nucleosynthesis

    NASA Astrophysics Data System (ADS)

    Utsunomiya, Hiroaki

    Photoneutron reactions are discussed in the context of nucleosynthesis with emphasis on a unified understanding of (γ, n) and (n, γ) reactions for heavy nuclei through the γ-ray strength function and a revisit to explosive nucleosynthesis of 9Be through the reciprocity theorem. The role of photonuclear reactions in nucleosynthesis is supplemented by the photonuclear data project (IAEA-CRP F42032) and will be strengthened in the Extreme Light Infrastructure-Nuclear Physics (ELI-NP) in the future.

  10. The Quantized Geometry of Visual Space: The Coherent Computation of Depth, Form, and Lightness. Revised Version.

    DTIC Science & Technology

    1982-08-01

    peripheral points on the retina. The expansion of spatial scales with retinal eccentricity is easily rationalized in this way (Hubel and Wiesel , 1977...cell can eli - cit a transient antagonf’tic rebound, or off-reaction, in the activity of the off-cell. Similarly, a sudden and equal arousal increment...competition between orientation sensitive dipole fields; in particular, a good physiological model of cortical hypercolumn organization (Hubel and Wiesel

  11. A Computational Study of Rigid Motion Perception.

    DTIC Science & Technology

    1986-12-01

    Hubel and Wiesel [46, 47], who postulated a h.e hierarchical functional architecture for visual processing with successively ’.’ ,P. ’ St- 0~ X7...large. This case has been analyzed extensi ely in the literature, [5, 42, 79], are some examples. The above methods deal with local analysis of the image...Image Sequence Analysis, T. S. Huang, (ed.), Springer- 0 Verlag, 1981, ch. 1. 46. D. H. Hubel and T. N. Wiesel , "Receptive field and Functional

  12. Probability Distribution of Impact for a Satellite Booster After Loss of Control.

    DTIC Science & Technology

    1979-03-01

    advisor, Capt. Bill Wiesel , for his advice and patience towards the completion of this study. Scott W. Benson ii Contents Acknowledgements...LON’F)E-LONGI) P=AB’ (DAOLA𔃺EDO-OD.DLO*OEDLA) *E<’ EL (I)= ELI 32 CONTINUE IF(L.GTo0)GO TO !3 LATI=O.O *=~c 13 CONTINUE LATI=LATI’ 180. 0/nt 23 TIME

  13. A Model for Human Visual Processing Which Explains Perceptions of Motion-After-Effects.

    DTIC Science & Technology

    1982-12-01

    direction of motion of the visual stimulus (Hubel and Wiesel 1959). Though little is known of the exact function of area 18 of the cortex, it is known...second inner square would immedia~ ely appear. Follow up questions posed to the other subjects found several to believe they had also observed the same...Hubel, D. H. and Wiesel , T. N. 1959. Receptive fields of single neurons in the cat’s striate cortex. J. Physiol. 148: 574-591

  14. Surface Observation Climatic Summaries (SOCS) for Hanau AAF, Germany

    DTIC Science & Technology

    1992-03-01

    oI L ...............- A V EtTIONH NAI6s mADAM AAF DL FIELD ELI’Y: 363 Fr LATITIUDE/LECSITUDEs 50 10 N 008 58 E STATIOC N C: 106420...r AVAILAULE FOR WMER REPO~nTil SITES. AIRIIEAR SEITIG. 3INCER OF CURY (80), TABLES GIVE Hk, W!nffARDA DEVIATIONS, AND SINTON VIOUM.YN IF INESS( MN CW

  15. Parameter Estimation for Real Filtered Sinusoids

    DTIC Science & Technology

    1997-09-01

    A]kL = aki. Finally, let J be a scalar function of b so that the gradient of J with respect to b is defined as VbJ = ... j ]T (B.1) The results of...Vbjl X LTAL _ zQ I-’Q 1bak~b _ Q TJ = btI b = = Z41 biakJb. = 1 akibk + EL=i ai 1b, [ VbJ ] = Ab + Ab Complex Scalar Derivatives Component Vector

  16. Improving Earthquake and Explosion Discrimination by Using Love and Rayleigh Wave Magnitudes (Postprint) Annual Report 3

    DTIC Science & Technology

    2012-03-22

    Rayleigh=2.9). Based on background noise levels, we conclude the Ms(VMAX)-Love must have been less than 2.5 (similar conclusion reached by Kohl et al...Benz for their assistance with this collaboration and research. We thank Drs. Jack Murphy, Eli Baker, Paul Richards, and Jeff Stevens for suggestions...discriminant. Maxwell Technologies Final Report. 23 p. Kohl , B., J. R., Murphy, J. Stevens, and T. J. Bennett (2011). Exploitation of the IMS and

  17. A Comparison of Critical Chain Project Management (CCPM) Buffer Sizing Techniques

    DTIC Science & Technology

    2007-11-02

    on Eli Goldratt ?s Theory of Constraints. Some of the literature notes this to be a significant departure from current methods; others claim it is...written about sizing the buffers when establishing the critical chain plan (notably Goldratt (1997), Leach (1999, 2000), Herroelen and Leus (2001...also been a reasonable amount written about sizing the buffers when establishing the critical chain plan (notably Goldratt (1997), Leach (1999, 2000

  18. A Case Study of the Degree of Collaboration Between Various Levels in the Reparable Chain in the United States Air Force

    DTIC Science & Technology

    2005-03-01

    about the same time Taichi Ohno was creating his famous TPS (Womack, et al, 1991:277). The Theory of Constraints was popularized by Eli Goldratt in...M. Goldratt . It acknowledges that every company has a general purpose or goal. Equally, every organization has obstacles preventing it from...achieving their goal called constraints. Dr. Goldratt states that a system’s constraint is anything that limits a system from achieving higher performance

  19. Analyzing C2 Greyhound Capacity at Fleet Readiness Center Southwest (FRC SW)

    DTIC Science & Technology

    2009-06-01

    B. ELEMENTS OF AIRSPEED The Theory of Constraints (TOC) was popularized by Eli Goldratt in his book titled The Goal (1984). The theory of...constraints has a fundamental thesis that a few constraints determine the performance of any system. Goldratt advocates managers to focus on constraints...minimize the cost (operational expense) of running it ( Goldratt , 1984). The second major component of Airspeed is its incorporation of Lean, a

  20. Using Depot Inventory Position to Determine Transportation Mode of Retrograde Reparable Assets

    DTIC Science & Technology

    2005-03-01

    could be used as a factor and shows the serviceable inventory could prove useful as well. 46 In his book The Goal, Eli Goldratt (1992) suggests...process, as this will just waste resources and not speed up the system ( Goldratt , 1992). If the depot is considered the bottleneck based on its... Goldratt , Eliyahu M. The Goa (Second Edition). Great Barrington MA. The North River Press, 1992. Hall, Patricia K. and Paul R. Murphy. “The

  1. Screening for Inhibitors of Essential Leishmania Glucose Transporters

    DTIC Science & Technology

    2013-07-01

    be used effectively in an automated high-throughput format (Assay Guidance Manual , http://www.ncgc.nih.gov/guidance/manual_toc.html). For initial...quality employing control samples. The details of recommended quality control tests are provided by the online Assay Guidance Manual published by Eli...values for this assay are well within the range of the ‘acceptance criteria’, as defined in the Assay Guidance Manual . Table 1. Summary of

  2. Screening for Inhibitors of Essential Leishmania Glucose Transporters

    DTIC Science & Technology

    2012-07-01

    high-throughput format (Assay Guidance Manual , http://www.ncgc.nih.gov/guidance/manual_toc.html). For initial optimization of the cell growth assay...The details of recommended quality control tests are provided by the online Assay Guidance Manual published by Eli Lilly and company and the NIH...within the range of the ‘acceptance criteria’, as defined in the Assay Guidance Manual . 6 Table 1. Summary of statistical variables calculated for

  3. Integrating the Acquisition Team. Proceedings of the Conference Held in Arlington, Virginia on July 14-16, 1986.

    DTIC Science & Technology

    1986-07-16

    Ruth Dewald) 2550 Huntington Ave. Uarren MI 48397-5000 Alexandria VA 22303-1499 (313) 574-8669 ET 786-8669 (703) 960-4900 ET AL mY Aldo Domenichini... Leopold , LTC, USAF Eli Lesser ESD/SCM OASD(A&L)IP&Q ESD/SCM Pentagon, Room 2A318 Hanscom AFB MA 01731 Uashington DC 20301- 617-271-6022 478-5980 (202

  4. Two-legged hopping in autism spectrum disorders

    PubMed Central

    Moran, Matthew F.; Foley, John T.; Parker, Mary E.; Weiss, Michael J.

    2013-01-01

    Sensory processing deficits are common within autism spectrum disorders (ASD). Deficits have a heterogeneous dispersion across the spectrum and multimodal processing tasks are thought to magnify integration difficulties. Two-legged hopping in place in sync with an auditory cue (2.3, 3.0 Hz) was studied in a group of six individuals with expressive language impaired ASD (ELI-ASD) and an age-matched control group. Vertical ground reaction force data were collected and discrete Fourier transforms were utilized to determine dominant hopping cadence. Effective leg stiffness was computed through a mass-spring model representation. The ELI-ASD group were unsuccessful in matching their hopping cadence (2.21 ± 0.30 hops·s−1, 2.35 ± 0.41 hops·s−1) to either auditory cue with greater deviations at the 3.0 Hz cue. In contrast, the control group was able to match hopping cadence (2.35 ± 0.06 hops·s−1, 3.02 ± 0.10 hops·s−1) to either cue via an adjustment of effective leg stiffness. The ELI-ASD group demonstrated a varied response with an interquartile range (IQR) in excess of 0.5 hops·s−1 as compared to the control group with an IQR < 0.03 hops·s−1. Several sensorimotor mechanisms could explain the inability of participants with ELI-ASD to modulate motor output to match an external auditory cue. These results suggest that a multimodal gross motor task can (1) discriminate performance among a group of individuals with severe autism, and (2) could be a useful quantitative tool for evaluating motor performance in individuals with ASD individuals. PMID:23532337

  5. Lebanon: Strategic and Political Challenges and Opportunities

    DTIC Science & Technology

    2008-03-31

    the current status quo, as well as U.S. aims for mutual defense pacts elsewhere in the region. President Chamoun had requested the American use of...political strife in May of 1958 between supporters and detractors of President Chamoun , it was carried out in the overall context of events which...ratified, and was finally formally revoked by the Lebanese Parliament at a later date. 57 Bilal Y . Saab and Elie D. Al-Chaer, “The Dilemma of Democracy

  6. Dolphin Continuous Auditory Vigilance for Five Days

    DTIC Science & Technology

    2006-01-01

    Brett Giroir, Amy Kruse between sleep and eye state in Cetaceans and Pinnipeds . Arch Ital. Biol. 142, 557-568.and Lisa Ely for support and encouragement...Brain Res. Suppl. Cockcroft, V. G. and Ross, G. J. B. (1990). Observations on the early 8, 227-238. development of a captive Bottlenose Dolphin calf. In...Soc. Am. 119, 3181-3192. mammal health: measures of the nervous and immune systems before and Flanigan, W. F., Jr (1974). Nocturnal behavior of captive

  7. Demetrius éginitis - sojourn in the paris and nice observatories (French Title: Demetrius éginitis - séjour dans les observatoires de paris et de nice)

    NASA Astrophysics Data System (ADS)

    Thorel, J. C.

    2008-10-01

    We give the measures of double stars reported by the Greek astronomer Demetrius ÉGINITIS during a short stay at the 38cm equatorial of Nice observatory in 1889. Our bibliographic researches has also let us know the measurements made at the 40cm Doridis equatorial of Athens observatory by J.S. PARASKEVOPOULOS (PAS) in 1915-1917 and by Demetrius P. ÉLIAS (ELI) in 1955. We think that these measures are missing in the WDS.

  8. Solution of the Average-Passage Equations for the Incompressible Flow through Multiple-Blade-Row Turbomachinery

    DTIC Science & Technology

    1994-02-01

    especially Mr. Tim A. Beach, Mr. Mark L. Celestina , and Dr. Kevin R. Kirtley-gave valuable recommendations throughout the project. Dr. Eli Turkel of...machine is briefly described in the following section. Though in significantly less detail, it is taken direcfly from Adamczyk, Mulac, and Celestina ...Adamczyk, Mulac, and Celestina [1986] devised a method for computing 5 for an inviscid single-stage machine. The method has the very attractive

  9. The French Huguenots of Colonial South Carolina: Assimilation or Acculturation

    DTIC Science & Technology

    1990-01-01

    Bacot, Elias Prioleau. Benjamin Marion, Dr. Isaac Porcher , Paul Mazyck, Elie Horry, and Gabriel Manlgault, whose estates appear in the probate records...8217Chelsea* was one of the oldest plantations in the parish. It was the home of the Porchers , St. Jullens, and the Ravenels--all prominent families in...1949. 9. DuBose, Samuel and Frederick A. Porcher , A Contribution to the History of the Huauenots of South Carolina. New York: Knickerbocker Press, 1887

  10. Recognizing and Treating the Physical Symptoms of Depression in Primary Care

    PubMed Central

    2004-01-01

    This Academic Highlights section of The Primary Care Companion to The Journal of Clinical Psychiatry presents the highlights from the teleconference “Recognizing the Physical Symptoms of Depression,” which was held March 16, 2004. The teleconference and this ACADEMIC HIGHLIGHTS were independently developed pursuant to an unrestricted educational grant from Eli Lilly and Company. This report was prepared by Physicians Postgraduate Press, Inc. PMID:15361920

  11. Industrial Mobilization: The Relevant History. Revised

    DTIC Science & Technology

    1983-01-01

    8 3 By 1953, then, Henry H. Fowler, the Director of Defense Mobl - lization had ident!fled four major mobilization jobs remaining to be done. The...electric, power, and certain vital nonferrous minerals. There were good reasons for this decision. First, the technology of Eli modern warfare requires vast...essential in high-temperature al- loy steel. Nickel, tungsten, molybdenum, and cobalt became in- creasingly important as military technology moved toward

  12. Faces of the Recovery Act: 1366 Technologies

    SciTech Connect

    Sachs, Ely; Mierlo, Frank van; Obama, Barack

    2010-01-01

    LEXINGTON, MA - At 1366 Technologies, Ely Sachs and Frank van Mierlo are using ARPA-E Recovery Act funding to dramatically reduce the costs of solar panel production. To read more about the project: http://arpa-e.energy.gov/FundedProjects.aspx#1366 To see more projects funded by the Recovery Act through ARPA-E: http://arpa-e.energy.gov/FundedProjects.aspx

  13. Abrupt Climate Change: A Magnetic Coupling Model (MCM) Prediction.

    NASA Astrophysics Data System (ADS)

    Ely, John T. A.

    2002-04-01

    Recent findings [p.8 ISBN 0-309-07434-7] show major climate changes often occur in a decade. This is another of many MCM predictions (see refs). All of them tested from 1968 to date have been proven, including: Global warming is real and driven by fossil fuel (1970's); This CO2 forcing has ended Major Ice Ages; All Major and Minor Ice Ages are caused by decreases in existing (primarily subvisible and other thin, especially newly forming) cirrus at mid to high geomagnetic latitudes; Ionization of the atmosphere near 250 grams per square cm depth by GCR (galactic cosmic ray protons circa 1 gev) cause cirrus depression; Ice cores and other proxy records show ice ages exhibit increased beryllium-10, carbon-14, etc, due to GCR. As noted in the Mar and Apr abstracts, the MCM predictable climate ended in 2000, following over 30 yrs of our ignoring its easily testable warnings re fossil fuel. Hence, we now face the somber question of whether human intervention is still possible in a CO2 Runaway and sea level rise that may be on a decade time scale. [Ely, Session A8, APS Mtg, Seattle, Mar 01; Ely, Session H14.013, APS Mtg, Apr 01; MCM pub list http://faculty.washington.edu/ely/MCM.html

  14. Pennsylvanian-Permian Antler foreland of eastern Nevada

    SciTech Connect

    Snyder, W.S. . Dept. of Geosciences); Trexler, J.H. Jr. . Dept. of Geological Sciences)

    1993-04-01

    Models for the Antler foreland generally assume that it was a Mississippian feature dominated by a single, large basin (the Antler foredeep). Recent work indicates that the foreland, as a tectonic region, is longer-lived, and is better described as a series of sub-basins separated by intervening structural highs. Long sections reveal space/time changes in depositional facies and sedimentologic features indicative or suggestive of this repeated tectonism. For example, in the southern Pancake Range, the fluvial-deltaic clastic units of the Late Mississippian-earliest Pennsylvanian Neward Canyon sequence are overlain by 540 m of cyclical Pennsylvanian Ely Limestone. The flooding event that marks the boundary between these units occurs during a long-term 2nd order eustatic low stand and thus reflects the regional tectonism that created the Ely basin'. Further, tectonically driven subsidence seems necessary to sustain deposition of the thick of marginal marine-open shelf Ely Limestone at this locality. Regionally, Early Permian deposition within the Dry Mountain trough was dominated by a complex series of local tectonic controls. Within eastern Nevada, tectonic influences on the stratigraphy continued through at least the Middle Permian, and this tectonism perhaps merged with that of the classic Late Permian-Early Triassic Sonoma orogeny. One consequence of this protracted tectonism was development or reactivation of zones of structural weakness that fragmented the foreland into a series of basins and highs and that accommodated differing geometries and styles of deformation.

  15. Amplification of ultra-short laser pulses via resonant backward Raman amplification in plasma

    NASA Astrophysics Data System (ADS)

    Mishra, S. K.; Andreev, A.

    2016-08-01

    In this paper, we have examined the possibility of using resonant backward Raman amplification (BRA) as an efficient mechanism in amplifying the low intensity ultra-short ( ≤ fs ) pulses using plasma as intermediate amplifying medium; such pulses are anticipated to get produced in the form of the secondary sources at ALPS (Attosecond Light Pulse Source) center of ELI (Extreme Light Infrastructure). In preliminary assessment of the scheme, the analytical expressions for the pump/seed laser pulses and plasma characteristic features are obtained which concisely describe the parameter regime of resonant BRA applicability in achieving significant amplification. The consistency of the scheme in the context of ELI-ALPS sources has been validated through particle in cell (PIC) simulations. The peak intensity of the amplified seed pulse predicted via simulation results is found in reasonable agreement with the analytical estimates. Utilizing these analytical expressions as a basis in perspective of ELI-ALPS parameter access, a specific example displaying the key plasma and laser parameters for amplifying weak seed pulse has been configured; the limitations and conceivable remedies in resonant BRA implementation have also been highlighted.

  16. Gamma ray beams for Nuclear Astrophysics: first results of tests and simulations of the ELISSA array

    NASA Astrophysics Data System (ADS)

    La Cognata, M.; Anzalone, A.; Balabanski, D.; Chesnevskaya, S.; Crucillà, V.; Filipescu, D. M.; Guardo, G. L.; Gulino, M.; Lattuada, D.; Matei, C.; Pizzone, R. G.; Romano, S.; Spitaleri, C.; Taffara, A.; Tesileanu, O.; Tumino, A.; Xu, Y.

    2017-03-01

    The Extreme Light Infrastructure-Nuclear Physics (ELI-NP) facility, under construction in Magurele near Bucharest in Romania, will provide high-intensity and high-resolution gamma ray beams that can be used to address hotly debated problems in nuclear astrophysics. For this purpose, a silicon strip detector array (named ELISSA) will be realized in a common effort by ELI-NP and INFN-LNS (Catania, Italy), in order to measure excitation functions and angular distributions over a wide energy and angular range. A prototype of ELISSA was built and tested at Laboratori Nazionali del Sud (INFN-LNS) in Catania with the support of ELI-NP. On this occasion, we carried out experiments with alpha sources and with a 11 MeV 7Li beam. Thanks to our approach, the first results of those tests show up a very good energy resolution (better than 1%) and very good position resolution, of the order of 1 mm. Below 1 MeV, a resolution of the order of 6 mm is found, still good enough for the measurement of angular distribution and the kinematical identification of the reactions induced on the target by gamma beams.

  17. New frontiers in nuclear physics with high-power lasers and brilliant monochromatic gamma beams

    NASA Astrophysics Data System (ADS)

    Gales, S.; Balabanski, D. L.; Negoita, F.; Tesileanu, O.; Ur, C. A.; Ursescu, D.; Zamfir, N. V.

    2016-09-01

    The development of high power lasers and the combination of such novel devices with accelerator technology has enlarged the science reach of many research fields, in particular particle and nuclear physics, astrophysics as well as societal applications in material science, nuclear energy and applications for medicine. The European Strategic Forum for Research Infrastructures has selected a proposal based on these new premises called the Extreme Light Infrastructure (ELI). The ELI will be built as a network of three complementary pillars at the frontier of laser technologies. The ELI-NP pillar (NP for nuclear physics) is under construction near Bucharest (Romania) and will develop a scientific program using two 10 PW lasers and a Compton back-scattering high-brilliance and intense low-energy gamma beam, a combination of laser and accelerator technology at the frontier of knowledge. This unique combination of beams that are unique worldwide allows us to develop an experimental program in nuclear physics at the frontiers of present-day knowledge as well as society driven applications. In the present paper, the technical description of the facility as well as the new perspectives in nuclear structure, nuclear reactions and nuclear astrophysics will be presented.

  18. Transportin Regulates Major Mitotic Assembly Events: From Spindle to Nuclear Pore Assembly

    PubMed Central

    Lau, Corine K.; Delmar, Valerie A.; Chan, Rene C.; Phung, Quang; Bernis, Cyril; Fichtman, Boris; Rasala, Beth A.

    2009-01-01

    Mitosis in higher eukaryotes is marked by the sequential assembly of two massive structures: the mitotic spindle and the nucleus. Nuclear assembly itself requires the precise formation of both nuclear membranes and nuclear pore complexes. Previously, importin alpha/beta and RanGTP were shown to act as dueling regulators to ensure that these assembly processes occur only in the vicinity of the mitotic chromosomes. We now find that the distantly related karyopherin, transportin, negatively regulates nuclear envelope fusion and nuclear pore assembly in Xenopus egg extracts. We show that transportin—and importin beta—initiate their regulation as early as the first known step of nuclear pore assembly: recruitment of the critical pore-targeting nucleoporin ELYS/MEL-28 to chromatin. Indeed, each karyopherin can interact directly with ELYS. We further define the nucleoporin subunit targets for transportin and importin beta and find them to be largely the same: ELYS, the Nup107/160 complex, Nup53, and the FG nucleoporins. Equally importantly, we find that transportin negatively regulates mitotic spindle assembly. These negative regulatory events are counteracted by RanGTP. We conclude that the interplay of the two negative regulators, transportin and importin beta, along with the positive regulator RanGTP, allows precise choreography of multiple cell cycle assembly events. PMID:19641022

  19. Transportin regulates major mitotic assembly events: from spindle to nuclear pore assembly.

    PubMed

    Lau, Corine K; Delmar, Valerie A; Chan, Rene C; Phung, Quang; Bernis, Cyril; Fichtman, Boris; Rasala, Beth A; Forbes, Douglass J

    2009-09-01

    Mitosis in higher eukaryotes is marked by the sequential assembly of two massive structures: the mitotic spindle and the nucleus. Nuclear assembly itself requires the precise formation of both nuclear membranes and nuclear pore complexes. Previously, importin alpha/beta and RanGTP were shown to act as dueling regulators to ensure that these assembly processes occur only in the vicinity of the mitotic chromosomes. We now find that the distantly related karyopherin, transportin, negatively regulates nuclear envelope fusion and nuclear pore assembly in Xenopus egg extracts. We show that transportin-and importin beta-initiate their regulation as early as the first known step of nuclear pore assembly: recruitment of the critical pore-targeting nucleoporin ELYS/MEL-28 to chromatin. Indeed, each karyopherin can interact directly with ELYS. We further define the nucleoporin subunit targets for transportin and importin beta and find them to be largely the same: ELYS, the Nup107/160 complex, Nup53, and the FG nucleoporins. Equally importantly, we find that transportin negatively regulates mitotic spindle assembly. These negative regulatory events are counteracted by RanGTP. We conclude that the interplay of the two negative regulators, transportin and importin beta, along with the positive regulator RanGTP, allows precise choreography of multiple cell cycle assembly events.

  20. Identification of two pentatricopeptide repeat genes required for RNA editing and zinc binding by C-terminal cytidine deaminase-like domains.

    PubMed

    Hayes, Michael L; Giang, Karolyn; Berhane, Beniam; Mulligan, R Michael

    2013-12-20

    Many transcripts expressed from plant organelle genomes are modified by C-to-U RNA editing. Nuclear encoded pentatricopeptide repeat (PPR) proteins are required as RNA binding specificity determinants in the RNA editing mechanism. Bioinformatic analysis has shown that most of the Arabidopsis PPR proteins necessary for RNA editing events include a C-terminal portion that shares structural characteristics with a superfamily of deaminases. The DYW deaminase domain includes a highly conserved zinc binding motif that shares characteristics with cytidine deaminases. The Arabidopsis PPR genes, ELI1 and DOT4, both have DYW deaminase domains and are required for single RNA editing events in chloroplasts. The ELI1 DYW deaminase domain was expressed as a recombinant protein in Escherichia coli and was shown to bind two zinc atoms per polypeptide. Thus, the DYW deaminase domain binds a zinc metal ion, as expected for a cytidine deaminase, and is potentially the catalytic component of an editing complex. Genetic complementation experiments demonstrate that large portions of the DYW deaminase domain of ELI1 may be eliminated, but the truncated genes retain the ability to restore editing site conversion in a mutant plant. These results suggest that the catalytic activity can be supplied in trans by uncharacterized protein(s) of the editosome.

  1. Revival of pure titanium for dynamically loaded porous implants using additive manufacturing.

    PubMed

    Wauthle, Ruben; Ahmadi, Seyed Mohammad; Amin Yavari, Saber; Mulier, Michiel; Zadpoor, Amir Abbas; Weinans, Harrie; Van Humbeeck, Jan; Kruth, Jean-Pierre; Schrooten, Jan

    2015-09-01

    Additive manufacturing techniques are getting more and more established as reliable methods for producing porous metal implants thanks to the almost full geometrical and mechanical control of the designed porous biomaterial. Today, Ti6Al4V ELI is still the most widely used material for porous implants, and none or little interest goes to pure titanium for use in orthopedic or load-bearing implants. Given the special mechanical behavior of cellular structures and the material properties inherent to the additive manufacturing of metals, the aim of this study is to investigate the properties of selective laser melted pure unalloyed titanium porous structures. Therefore, the static and dynamic compressive properties of pure titanium structures are determined and compared to previously reported results for identical structures made from Ti6Al4V ELI and tantalum. The results show that porous Ti6Al4V ELI still remains the strongest material for statically loaded applications, whereas pure titanium has a mechanical behavior similar to tantalum and is the material of choice for cyclically loaded porous implants. These findings are considered to be important for future implant developments since it announces a potential revival of the use of pure titanium for additively manufactured porous implants.

  2. The Development of a Roof Integrated Solar Hot Water System

    SciTech Connect

    Menicucci, David F.; Moss, Timothy A.; Palomino, G. Ernest

    2006-09-01

    The Salt River Project (SRP), in conjunction with Sandia National Laboratories (SNL) and Energy Laboratories, Inc. (ELI), collaborated to develop, test, and evaluate an advanced solar water-heating product for new homes. SRP and SNL collaborated under a Department of Energy Cooperative Research and Development Agreement (CRADA), with ELI as SRP's industry partner. The project has resulted in the design and development of the Roof Integrated Thermal Siphon (RITH) system, an innovative product that features complete roof integration, a storage tank in the back of the collector and below the roofline, easy installation by homebuilders, and a low installed cost. SRP's market research guided the design, and the laboratory tests conducted at SNL provided information used to refine the design of field test units and indicated that the RITH concept is viable. ELI provided design and construction expertise and is currently configured to manufacture the units. This final report for the project provides all of the pertinent and available materials connected to the project including market research studies, the design features and development of the system, and the testing and evaluation conducted at SNL and at a model home test site in Phoenix, Arizona.

  3. Exenatide: AC 2993, AC002993, AC2993A, exendin 4, LY2148568.

    PubMed

    2004-01-01

    Exenatide [AC002993, AC2993A, AC 2993, LY2148568, exendin 4], a glucagon-like peptide-1 (GLP-1) agonist, is a synthetic exendin 4 compound under development with Amylin Pharmaceuticals for the treatment of type 2 diabetes. Both exendin 4 and its analogue, exendin 3, are 39-amino acid peptides isolated from Heloderma horridum lizard venom that have different amino acids at positions 2 and 3, respectively. Exendins are able to stimulate insulin secretion in response to rising blood glucose levels, and modulate gastric emptying to slow the entry of ingested sugars into the bloodstream. Amylin Pharmaceuticals acquired exclusive patent rights for the two exendin compounds (exendin 3 and exendin 4) from the originator, Dr John Eng (Bronx, NY, US). On 20 September 2002, Amylin and Eli Lilly signed a collaborative agreement for the development and commercialisation of exenatide for type 2 diabetes. Under the terms of the agreement, Eli Lilly has paid Amylin a licensing fee of 80 million US dollars and bought Amylin's stock worth 30 million US dollars at 18.69 US dollars a share. After the initial payment, Eli Lilly will pay Amylin up to 85 US dollars million upon reaching certain milestones and also make an additional payment of up to 130 million US dollars upon global commercialisation of exenatide. Both companies will share the US development and commercialisation costs, while Eli Lilly will pick up up to 80% of development costs and all commercialisation costs outside the US. Amylin and Eli Lilly will equally share profit from sales in the US, while Eli Lilly will get 80% of the profit outside the US and Amylin will get the rest. This agreement has also enabled Amylin to train its sales force to co-promote Lilly's human growth hormone Humatrope. Alkermes will receive research and development funding and milestone payments, and also a combination of royalty payments and manufacturing fees based on product sales. Alkermes undertakes the responsibility for the development

  4. Hierarchical micro-nano structured Ti6Al4V surface topography via two-step etching process for enhanced hydrophilicity and osteoblastic responses.

    PubMed

    Moon, Byeong-Seok; Kim, Sungwon; Kim, Hyoun-Ee; Jang, Tae-Sik

    2017-04-01

    Hierarchical micro-nano (HMN) surface structuring of dental implants is a fascinating strategy for achieving fast and mechanically stable fixation due to the synergetic effect of micro- and nano-scale surface roughness with surrounding tissues. However, the introduction of a well-defined nanostructure on a microstructure having complex surface geometry is still challenging. As a means of fabricating HMN surface on Ti6Al4V-ELI, target-ion induced plasma sputtering (TIPS) was used onto a sand-blasted, large-grit and acid-etched substrate. The HMN surface topography was simply controlled by adjusting the tantalum (Ta) target power of the TIPS technique, which is directly related to the Ta ion flux and the surface chemical composition of the substrate. Characterization using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and laser scanning microscopy (LSM) verified that well-defined nano-patterned surface structures with a depth of ~300 to 400nm and a width of ~60 to 70nm were uniformly distributed and followed the complex micron-sized surface geometry. In vitro cellular responses of pre-osteoblast cells (MC3T3-E1) were assessed by attachment and proliferation of cells on flat, nano-roughened, micro-roughened, and an HMN surface structure of Ti6Al4V-ELI. Moreover, an in vivo dog mandible defect model study was used to investigate the biological effect of the HMN surface structure compared with the micro-roughened surface. The results showed that the surface nanostructure significantly increased the cellular activities of flat and micro-roughened Ti, and the bone-to-implant contact area and new bone volume were significantly improved on the HMN surface structured Ti. These results support the idea that an HMN surface structure on Ti6Al4V-ELI alloy has great potential for enhancing the biological performance of dental implants.

  5. Reporting on Climate Change: Understanding the Science, Third Edition

    SciTech Connect

    Ward, Morris A.; Parker, Elissa A.

    2003-10-10

    The Environmental Law Institute, the grantee, in the final quarter of operation under Department of Energy Grant DE-FG02-02ER63414, successfully completed the following tasks associated with the grant: (1) published ''Reporting on Climate Change: Understanding the Science'', the third edition of this resource intended primarily to help print and broadcast journalists report more effectively on scientific aspects of global climate change; (2) distributed the reporters guide directly to roughly 500 journalists and journalism educators participating in the annual meeting of the Society of Environmental Journalists in New Orleans, La.; (3) distributed the reporters guide to an additional 1,500 journalists and journalism educators by mail; (4) provided journalism educators bulk copies, upon specific request, for their use in upper-level science journalism and environmental journalism classes; (5) conducted outreach to science editors and environmental reporters on availability and use of the reporter's guide; (6) completed financial reporting associated with the reporter's guide grant. ELI has provided requested bulk numbers of copies of ''Reporting on Climate Change: Understanding the Science'' to the DOE Project Officer, David C. Bader, Ph.D., and to Jeffrey Amthor, Ph.D., in the Office of Science. ELI currently has a remaining inventory of roughly 500 copies from the original printing of more than 3,000 copies of the guide. These copies are used for responding to continuing requests from journalists and educators for the guide. ELI is currently exploring opportunities for reprinting additional copies to help meet the continuing demand from the educational and journalism communities.

  6. High heterogeneity and low reliability in the diagnosis of major depression will impair the development of new drugs

    PubMed Central

    Castle, David J.; Pantelis, Christos; Hopwood, Malcolm; Young, Allan Hunter; Everall, Ian P.

    2015-01-01

    Summary Major depressive disorder is a common diagnosis associated with a high burden of disease that has proven to be highly heterogeneous and unreliable. Treatments currently available demonstrate limited efficacy and effectiveness. New drug development is urgently required but is likely to be hindered by diagnostic limitations. Declarations of interest D.J.C. has received grants and personal fees from Eli Lilly, Janssen-Cilag, Roche, Allergen, Bristol-Myers Squibb, Pfizer, Lundbeck, AstraZeneca, Hospira, Organon, Sanofi-Aventis, and Wyeth during the writing of this review. C.P. has received grant support from Janssen-Cilag, Eli Lilly, Hospira (Mayne), AstraZeneca, and received honoraria for consultancy to Janssen-Cilag, Eli Lilly, Hospira (Mayne), AstraZeneca, Pfizer, Schering Plough, and Lundbeck. Over the past 2 years he has participated on advisory boards for Janssen-Cilag and Lundbeck, and received honoraria for talks presented at educational meetings organised by AstraZeneca, Janssen-Cilag and Lundbeck. M.H. has received personal fees or grants from Lundbeck, AstraZeneca and Servier during the writing of this review. A.H.Y. reports personal fees from Lundbeck, Sunovion, AstraZeneca and Janssen outside the submitted work. I.P.E. has received personal fees or grants from Lundbeck, AstraZeneca, and Abbvie during the writing of this review. Copyright and usage © The Royal College of Psychiatrists 2015. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence. PMID:27703745

  7. Draft Environmental Impact Statement. MX Deployment Area Selection and Land Withdrawal/Acquisition DEIS. Volume IV. Part II. Environmental Consequences to the Study Regions and Operating Base Vicinities.

    DTIC Science & Technology

    1980-12-01

    163 4.3.1.8-2 Relationship between bighorn sheep range and the Coyote Spring Valley operating base location. 4-167 4.3.1.8-3 Bighorn sheep range and...249 4.3.1.10-4 Relationship between wilderness areas and Alternative 8 project activities, Texas/New Mexico. 4-251 4.3,2.1-1 Nevada/Utah region of...sensi- tivity in the vicinity of the Ely, Nevada OB. 4-740 4.3.2.14-7 Relationship between areas of high archaeological and historical senstivity

  8. Southeast Asia Report

    DTIC Science & Technology

    2007-11-02

    Peninsula, if it wants to. "Whether UMNO is successful or not in getting into Sabah does not depend on the strength of that party but on whether it is...absolu’ely lose thelr( credibility and influence in Da. vao City. ■•’■.. As Pavaoeflos,: we all : know, that the Alsa Masa*’. Is, a: high -* ly...to 9 percent and Europe from 21 to 30 percent. Before 1974, the United States was the leader of high technology, inventing 70 percent of the world’s

  9. Plasma Wave Turbulence and Particle Heating Caused by Electron Beams, Radiation, and Pinches.

    DTIC Science & Technology

    1983-01-01

    EhEmhmhEmhohhE 111.0 t 18 Eli911-- 1.25 1111 L.4 11111U-.6 MICROCOPY RESOLUTION TEST CHART NATIONAL BUREAU OF STANDARDS-1963-A L _ _ _ _ __ _ _ AIR FORCE OFFICE...and Pinch Martin V. Goldman, Principal Investigator M I ,,, b, - EL C T E ea for publto ic , g 06 10 043 1.4 "low’ I = t AIR FORCE OFFICE OF SCIENTIFIC...Martin V. Goldman, Principal Investigator AFOSR-80-0022 CU#-1533201 January, 1983 Accession For NTIS GRA&Z DTIC TAB Unannounced Q AIR FORCE OTFT O

  10. 65. DETAIL OF STOVER WINDMILL REGULATOR (MADE BY STOVER MFG. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    65. DETAIL OF STOVER WINDMILL REGULATOR (MADE BY STOVER MFG. CO., FREEPORT, ILL.) MOUNTED ON STEEL WINDMILL TOWER WITH ELI WINDMILL ON THE GROUND AT STOLL RESIDENCE ABOUT 1-1/2 MILES WEST OF NEBRASKA CITY ON STEAM WAGON ROAD. WINDMILL REGULATORS AUTOMATICALLY TURNED OFF WATER PUMPING WINDMILLS WHEN WATER RESERVOIRS FILLED. INSCRIPTION ON CASTING READS '6-8-9-10 FT. MILLS,' THE SIZES FOR WHICH THIS REGULATOR WAS MADE. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  11. Analytical Support for the Joint Chiefs of Staff: The WSEG Experience, 1948-1976

    DTIC Science & Technology

    1979-07-01

    respecti ely, Robert S. McNamara, James E. Webb, Glenn T. Seaborg , Alan T. Waterman, John W. Macy, Jr., and Jerome B. Wiesnur. Bl.reau of the Budget...Hammond, and Glenn H. Snyder, Strategy, PoZitics, and Pzense Budgets (New York: Columbia University Press, 1962), pp. 164-74. 18 "Both sides had their...a general discussion of this contextual climate, see Maier, "Science, Politics, and Defense in the Eisenhower Era" and Glenn H. Snyder, "The ’New

  12. M-X Environmental Technical Report. Environmental Characteristics of Alternative Designated Deployment Areas, Traffic.

    DTIC Science & Technology

    1980-12-22

    Siting Analysis Roads Texas virornental Report Utah New Mexico STRACT (Continue on reverse aide if necessary and identify by block number) 2Tn!s report...1.2.4.1 DDA 8 1.2.4.2 Operating Bases 8 2.0 Summary of Impacts 13 3.0 Baseline Environment 25 3.1 Nevada/ Utah Deployment Area 25 3.2 Texas/New Mexico...Deployment Area .31 3.3 Proposed Operating Base Locations 40 3.3.1 Beryl, Utah 40 3.3.2 Coyote Spring, Nevada 40 3.3.3 Delta, Utah 40 3.3.4 Ely, Nevada

  13. Aircraft Trajectories Computation-Prediction-Control. Volume 1 (La Trajectoire de l’Avion Calcul-Prediction-Controle)

    DTIC Science & Technology

    1990-03-01

    technologique des equipements de bord sur Ia conduite des aironefs. Elie comprend deux contributions. La premiire est consacrie it l’utilisation...d’ordinateurs de bord en vue d’ansiliOrer l’efficacit6 du transport aerien, Iasaeconde aborde, sujet difficile s’ii en eat, Ie r6Ie de l’lomme devant...Combusti~ble A prendre A bord , Ia v~rification par I. pilote do boo fonctionnegent des syatlaes lea plua importmnts. Le rlanltat de Vactivitil

  14. Advanced Metallic Air Vehicle Structure Program

    DTIC Science & Technology

    1976-02-01

    mechanical property testing on EB/GTA welded 10 Nickel steel and crack growth testing on both 6A1- 4V titanium and 10 Nickel steel, was reinstated 16...decided that no tension stresses were high enou);h to indicate a potential fatigue problem. As a measure of the efficacy of the test fixture in applying...f.tOfC PATrj ANDOft -- I". .0LDV SNOW FEW -~~ .15fSTI 0. V~NCA PP AfO "~ 07 LL 96 U ~ ~ ~ ~ W 4SS AL AA..A .VAII *- 4v Eli !. RAA 3LF,,0S W CI . . 1

  15. Applications of Ultra-Intense, Short Laser Pulses

    NASA Astrophysics Data System (ADS)

    Ledingham, Ken W. D.

    The high intensity laser production of electron, proton, ion and photon beams is reviewed particularly with respect to the laser-plasma interaction which drives the acceleration process. A number of applications for these intense short pulse beams is discussed e.g. ion therapy, PET isotope production and laser driven transmutation studies. The future for laser driven nuclear physics at the huge new, multi-petawatt proposed laser installation ELI in Bucharest is described. Many people believe this will take European nuclear research to the next level.

  16. 29. SOUTHEAST ACROSS BLACKSMITH SHOP AREA TOWARD TWO CIRCA 1900 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    29. SOUTHEAST ACROSS BLACKSMITH SHOP AREA TOWARD TWO CIRCA 1900 DRILL PRESSES ALONG THE EAST INTERIOR WALL AT THE NORTHEAST CORNER OF THE FACTORY BUILDING. THE HOODED FORGE IS VISIBLE IN THE LEFT FOREGROUND, SHOWING LADLES USED FOR POURING BABBITT BEARINGS. MOUNTED ON THE WORK BENCH IS THE MAIN CASTING FROM AN ELI WINDMILL, USED AS A JIG TO SUPPORT PARTS DURING THE BABBITT BEARING POURING OPERATION. THE WALL ABOVE THE WORKBENCH SHOWS THE BOARDED-UP OPENING FOR A FORMER WINDOW. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  17. New Look on 3-Hydroxyiminoflavanone and Its Palladium(II) Complex: Crystallographic and Spectroscopic Studies, Theoretical Calculations and Cytotoxic Activity.

    PubMed

    Kasprzak, Maria; Fabijańska, Małgorzata; Chęcińska, Lilianna; Szmigiero, Leszek; Ochocki, Justyn

    2016-04-13

    This work presents the synthesis, spectroscopic properties and single-crystal X-ray examination of the structure of 3-hydroxyiminoflavanone and its palladium complex. It presents the results of NMR (Nuclear Magnetic Resonance) spectroscopy, electron-density studies based on X-ray wavefunction refinement and theoretical calculations combined with QTAIM (Quantum Theory of Atoms in Molecules) and ELI-D (Electron Localizability Indicator) analyses. These offer an interesting new insight into the structures and behavior of flavanone and its complex, in solid state and in solution. The study also examines the cytotoxicity of the ligand and its complex against three human ovarian and lung cancer cell lines.

  18. Passive and Active Control of Massively Separated High-Speed Flows

    DTIC Science & Technology

    2014-01-31

    V. Kale , J. Craig Dutton, Gregory S. Elliott. Experimental Characterization of a Pulsed Plasma Jet, AIAA Journal, (06 2013): 0. doi: 10.2514/1...2012 08/16/2011 18.00 11.00 13.00 12.00 Received Paper 9.00 5.00 Bradley G. DeBlauw, Eli Lazar, Nachiket Kale , Nick Glumac, Craig Dutton, Gregory Elliott...of Arc Filament Plasma Actuators, 2012 AIAA Aerospace Sciences Meeting. 09-JAN-12, . : , Nachiket V. Kale , J. Craig Dutton, Gregory S. Elliott4

  19. Advances in Techniques and Technologies for Air Vehicle Navigation and Guidance

    DTIC Science & Technology

    1989-12-01

    machine et la responsabilite de [a mission. Un troisieme type d’aideenvisageable est I’aide a laconduite. Elie represente un prolongement naturel de [a...l’angle de prise do vue et de corrections inter- capteurs . 42-7 IL METHODE DE RECALAGE ROBUSTE 1. Cholx des algorlthmes optimaux Un syst~me de recalage...en ocuvre ou do fiabilitd mfit fixo travorsant le rotor, syst~fe de rotation dos captours au bout d’un mit dloignant ces capteurs de Ia zone

  20. 6. South View of Whitneyville in Hamden, 1836 by John ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. South View of Whitneyville in Hamden, 1836 by John Warner Barber Photocopied from John Warner Barber, Connecticut Historical Collections (New Haven, 1856), p. 220. 'The engraving... shows the appearance of the little village of Whitneyville, as seen from a few rods south, on the New Haven road.' (Barber, p. 219). The right fork, with Ithiel Town's truss, carries the New Haven & Hartford Turnpike, the left the Cheshire Turnpike. The factory is on the right, the village on the left. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  1. 10. Whitney Arms Company, Van Slyck steel engraving, 1880 Photocopied ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Whitney Arms Company, Van Slyck steel engraving, 1880 Photocopied from Charles B. Norton, American Inventions and Improvements in Breech-Loading Small Arms (Springfield, Mass., 1880), p. 154 The engraving does not seem to have been included in the earlier 1872 edition. This is probably the single most widely copied view of the Whitney Arms Company works, and it is without doubt the most accurate. Compare with site plan, photo CT-2-13. - Eli Whitney Armory, West of Whitney Avenue, Armory Street Vicinity, Hamden, New Haven County, CT

  2. Fracture control of H-O engine components. [titanium tin alloy fuel pump impellers

    NASA Technical Reports Server (NTRS)

    Ryder, J. T.

    1977-01-01

    An investigation was made to obtain the material characterization and fatigue crack propagation data necessary to establish the salient characteristics of a Ti-6Al-2.5Sn(ELI) alloy fuel pump impeller to be used in a cryogenic service environment. Testing variables considered were: coupon orientation, frequency, load range ratio, and temperature. Data analysis correlated crack propagation data from conventional laboratory coupons with data from a parallel sided rotating disk used to model rotor stresses. Four major design recommendations when bore regions of fuel pump impellers to be operated in cryogenic environments are to be relatively highly stressed are discussed.

  3. Vertigo in childhood: a methodological approach.

    PubMed

    Dispenza, F; De Stefano, A

    2012-01-01

    Children complaints dizziness merit meticulous evaluation to differentially diagnose a vestibular disease. A syndrome mimicking certain classic signs and symptoms of adult vestibular disorders may be presents in children, such as benign paroxysmal positional vertigo, usually associated with aging. Benign paroxysmal vertigo, in which migraine is a manifestation, with sudden onset of dizziness is a rare peripheral vestibular disorder that is commonly ignored or misdiagnosed. This review covers the development of the diagnosis, evaluation and treatment approaches of vertigo of childhood, a valid support for physician that approach dizzy children (Ref. 25). Full Text in PDF www.elis.sk.

  4. Interaction of identically charged particles in a pulsed field of two laser waves propagating in the one direction

    NASA Astrophysics Data System (ADS)

    Starodub, S. S.; Roshchupkin, S. P.

    2015-07-01

    We consider the effective interaction force of identically charged nonrelativistic particles (electrons and heavy nuclei) in a strong pulsed field of two co-propagating laser waves. It is shown that under certain conditions, the effective interaction force can become a force of attraction. Moreover, it is possible to significantly increase the duration of the effective force of attraction via the time shift of the pulse peak of the second wave relatively to the first one. The appearance of the effective force of attraction may be experimentally verified in the framework of modern research projects, which use sources of pulsed laser radiation (FAIR, XFEL, ELI).

  5. Faraday cup: absolute dosimetry for ELIMED beam line

    NASA Astrophysics Data System (ADS)

    Leanza, R.; Romano, F.; Scuderi, V.; Amico, A. G.; Cuttone, G.; Larosa, G.; Margarone, D.; Milluzzo, G.; Petringa, G.; Pipek, J.; Schillaci, F.; Cirrone, G. A. P.

    2017-03-01

    The scientific community has shown a growing interest towards multidisciplinary applications of laser-driven beams. In this framework, the ELIMED (ELI-Beamlines MEDical and multidisciplinary applications) beamline will be the first transport beamline dedicated to the medical and multidisciplinary studies with laser-accelerated ion beams. Detectors for dosimetry represent one of key-element of the ELIMED beamline, allowing a dose delivering with good result as required in the clinical applications. In this contribution, a Faraday Cup for absolute dosimetry, designed and realized at INFN-LNS, is described.

  6. The influence of composition, annealing treatment, and texture on the fracture toughness of Ti-5Al-2.5Sn plate at cryogenic temperatures

    NASA Technical Reports Server (NTRS)

    Vanstone, R. H.; Shannon, J. L., Jr.; Pierce, W. S.; Low, J. R., Jr.

    1977-01-01

    The plane strain fracture toughness K sub Ic and conventional tensile properties of two commercially produced one-inch thick Ti-5Al-2.5Sn plates were determined at cryogenic temperatures. One plate was extra-low interstitial (ELI) grade, the other normal interstitial. Portions of each plate were mill annealed at 1088 K (1500 F) followed by either air cooling or furnace cooling. The tensile properties, flow curves, and K sub Ic of these plates were determined at 295 K (room temperature), 77 K (liquid nitrogen temperature), and 20 K (liquid hydrogen temperature).

  7. Fatigue strength of a Ti-6Al-4V alloy produced by selective laser melting

    NASA Astrophysics Data System (ADS)

    Gerov, M. V.; Vladislavskaya, E. Yu.; Terent'ev, V. F.; Prosvirnin, D. V.; Kolmakov, A. G.; Antonova, O. S.

    2016-10-01

    The fatigue properties and the fracture mechanisms of the Ti-6Al-4V alloy produced by selective laser melting (SLM) from a powder of an CL41TiELI titanium alloy have been studied. Cylindrical blanks were grown at angles of 90° and 45° to a platform. The best fatigue strength is observed in the samples the blanks of which were grown at an angle of 45°. It is found that the structure of the SLM material can contain portions with unmelted powder particles, which are the places of initiation of fatigue cracks.

  8. Application of Time-Resolved Spectroscopies to the Study of Energetic Materials - 1981. A Summary Report.

    DTIC Science & Technology

    1982-03-05

    pulse uv photolysis (25 ps, 266 nm, 10 MJ) of C2 112 . The dominant emissive fragment product is the carbon diradical, C2 di, and its consequent Swan...signal appear to indicate extre,,ely rapid (< 20 ps) formation of the fragment. The fluorescent signal was found to be linear in UV excitation and probe...Marr-mne, P. F. Schoei, T.. S9. Goldberg, R. G. Weiss, .1. M. Scliruir tod W. 1- Faust. The UV photolysis of nitromethane has been studied extensively

  9. United States Persian Gulf Policy since 1968.

    DTIC Science & Technology

    1988-04-01

    CATES, USAF FACULTY ADVISOR LT COL THOMAS M. HENNEMAN , ACSC/EDN SPONSOR DR. RUSSELL W. RAMSEY, ACSC/EDN Submitted to the faculty in partial fulfillment...UNLIMITED [M SAME AS RPT. C DTIC USERS UNCLASSIFIED 22a. NAME OF RESPONSIBLE INDIVIDUAL 22b. TELEPHONE (Include Area Code) 2c. OFFICE SYMBOL ACCE2C. Mxwel...an J I C -’I LI Ely~:b~u’I~ % c ~ -ABOUT THE AUTHOR Major Cates is a 1973 graduate of the Virginia Mil’tary Institute where he received a BA in History

  10. 36. SOUTHWEST TO BELTPOWERED CIRCA 1900 DROP HAMMER IN NORTHEASTERN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. SOUTHWEST TO BELT-POWERED CIRCA 1900 DROP HAMMER IN NORTHEASTERN QUADRANT OF FACTORY OPPOSITE FROM THE BLACKSMITH SHOP AREA. THIS MACHINE WAS USED TO SHAPE THE STEEL VANE HINGE PART AFTER IT WAS HEATED IN THE FORGE IN THE ADJACENT BLACKSMITH SHOP AREA. USE OF THE ROTATING POWER OF THE PULLEY AT THE TO MADE LIFTING THE HAMMER COMPARATIVELY QUICK AND EASY. AROUND THE MACHINE ARE WHEEL PARTS FOR ELI WINDMILLS. AT THE LEFT FOREGROUND IS A CIRCA 1900 FOUR-SPINDLE PRODUCTION DRILL PRESS WHICH WAS RELOCATED TO THIS AREA APPARENTLY AFTER THE END OF WINDMILL MANUFACTURE. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  11. The Role of the Iranian Armed Forces in the Fall of the Shah.

    DTIC Science & Technology

    1984-06-01

    Country Study" (1982), p. 12. 54. "Iran Survey," Europa Yearbook1 Vol. 2, 1980, p. 5311 Sullivan, Mission to Iran1 pp. 182 and 199j and The Times Journal...World Bank, "A Study of the Agricultura ] Development of Iran" ( 1974). 18. Farhad Kazemi, "The Military and Politics In Iran,," in Elie Kedouri arid...New York), Volume 11, 1980. Europa Yearbk 4 Volume 2, 1980. Evening Post (Manila), 1978-1979. Facts on File Yearbook (New York), Volume XXXIX, 1979

  12. Tracking a Hypersonic Aircraft from a Space Platform

    DTIC Science & Technology

    1989-12-01

    my faculty advisor, Dr. W. E. Wiesel , for his expertise, interest, and continuing involvement amidst trying circumstances. A great big, special thanks...OEl j Of Of 1 2 (j] T= [ Az ] (3.18) Of Of L OE1 C1 j where -Of 1 [tan sin- {sin [Ell- + sin-:L r-e sin Eli cos Az] tan AzI z - / 7 2 -1 -11( sec sin...derived from Wiesel t3:1-146) except when annotated otherwise. 4-1 Data Vector The data vector, 7, input to the Kalnan filter is a two element vector

  13. Effect of Two-Body Motion on Radar Beam Quality for Various Distributed Sparse Array Configurations

    DTIC Science & Technology

    1988-12-01

    help of many. I would like to thank my thesis advisor, Dr. W. E. Wiesel , for his patience and encouragement throughout the duration of this project. I...corltirue =sm re,1 tururn 7 4 Riblioaraphy 1. Brookner, Eli "Phased-Array Radars," S American. 2J: 94-102 (February 1985). 2. Canan, James W "USAF in the...Warren L. and Thiele, Gary A. Antenna -1 Theory a-nd Design. New York: John Wiley and Sons, 1981. 10. Wiesel , William E Jr. Class handout distributed

  14. Robust Grasp Design Using Grasp Force Focus Positioning

    DTIC Science & Technology

    1991-12-12

    Eddy for helping me out with my many computer and software headaches. In addition, I’d like to thank my committee members. Dr. William Wiesel arid Dr...Cos(TOI)*E I *D41 - E2 I*Sin(TOI)*D41 Tau3I = -(D51 E3I1) - Cos(TOI)* ElI *D61 - E2 I*Sin(TOI)*D6] TauO2 =Cos(T92)*(D 12 + Lo*Sin(Po))*E22-(D 12 + Lo*Sin

  15. Orbit Determination of Sunlight Illuminated Objects Detected by Overhead Platforms

    DTIC Science & Technology

    1989-06-01

    all I would like to thank Dr. Wiesel and Capt Bain for their never ending support and patience when the going got tough. I also 5 wish to thank the...derived in many control theory texts, but its use for our purposes Wiesel derives it in terms of the required dynamical equations (18:26). In short...Therefore, the observations can be notationally expressed as Az,,, Az, + eg i (4.2) Elm t Eli + esI where CAI Iel - the it azimuth and elevation

  16. Locating an Imaging Radar in Canada for Identifying Spaceborne Objects

    DTIC Science & Technology

    1992-12-01

    continue with this thesis-, and Dr. William Wiesel for his instruction and help in developing a satellite coordinate frame and understanding the mechanics...64.036 1 .m r ris.W jL "r set. P r 1-3237.8660 set.Q = -25308.611 ’km r set.W j. r Eli R12 R13 r set.I set set set set.P r r r r r r R21 R22 R23 r

  17. Closed-Loop Control of a Satellite in an Unstable Periodic Orbit about L3.

    DTIC Science & Technology

    1981-12-01

    Wiesel , since I first walked into his classroom. I believe it rare for a man to hold so much knowledge and yet also exhibit such infinite patience...The Moon’s motion is approximated as a periodic orbit about the Earth as developed by Professor Wiesel in his work (Ref 25), which is more realistic...1977. 11. Kronmiller, G.C. Jr. and Elie J. Baghdadv. "The C RARR System: Concept Design, and Performance," Space Science Reviews, 5:265-307 Jul- 1066

  18. United States Air Force Statistical Digest, Fiscal Year 1959. Fourteenth Edition

    DTIC Science & Technology

    1959-09-30

    23 Feb 2011 DEPARTMENT OF THE AIR. FOIlCB SAFIPA CLI!AllED nus INFORMATION FEB 2 3 2011 FOil PUBUC Rl!LI!ASB 2. SAFIFMC has no objection to...submitter. Attachment 6 Copies (required) Signedievb/02231l1fmcee Eli V. Brown, Maj, USAF SAFIFMCEE DEPARTMENT OF THE AIR FORCE WASHINGTON. DC...TO ATTN OF: ACMe DEPARTMENT oFtn1E:A"R,FORCE HEAboUART~RS UNITED STATES AIR.~ORCE WASHINGTON. D.C. 1: SEP 197B SU."CT, . Declassification of

  19. Economic Evaluation of Proposed Helicopter Lidar Bathymeter System

    DTIC Science & Technology

    1990-02-01

    R’ .MPA .... AS 4 4 * ~ .~,VA A I- -~ flt3 .. AS ELY L i U IT 0F Z) FEDERAL . 0JECT- P ST (AAIA=VER)§ NS "#- " V I ? .......... " -’ cttUCsAc F~. A N...IIS, Figure E_-21 CORPS OF ENGINEERS US. A RMY I ARN1!! -HAR1BOR RO)UTCT I 614 OCt A 1,40 . 1 30 fT. vf,.II. 68 UU T f (0T3?1 OtIGL (rFrI CO I IfoR1 5

  20. Software Reuse Issues

    NASA Technical Reports Server (NTRS)

    Voigt, Susan J. (Editor); Smith, Kathryn A. (Editor)

    1989-01-01

    NASA Langley Research Center sponsored a Workshop on NASA Research in Software Reuse on November 17-18, 1988 in Melbourne, Florida, hosted by Software Productivity Solutions, Inc. Participants came from four NASA centers and headquarters, eight NASA contractor companies, and three research institutes. Presentations were made on software reuse research at the four NASA centers; on Eli, the reusable software synthesis system designed and currently under development by SPS; on Space Station Freedom plans for reuse; and on other reuse research projects. This publication summarizes the presentations made and the issues discussed during the workshop.

  1. Installation Restoration Program. Phase I. Records Search, Grand Forks Air Force Base, North Dakota.

    DTIC Science & Technology

    1985-04-01

    aggression. The mission of the 321st 2-6 4 th AIR DIVISION ElI 321 SMW 319 BMW II II SCAI I IIIIOIPB I SOCIA C 0I I A ITI’°" c’a" GROW OPLAINS MI~[NuI BCIS... crystals of pyrite, fragments of coal and carbonized wood, and spherulites of light-grownish-gray siltstone. The uppermost unit is a clean quartzose...introduction of the deisel fuel. Almost all of the fuel is burned. Grass growing in the pit indicates a lack of contamination in the area. Finley Radar Site The

  2. Strategies for Improving Labor and Equipment Data Acquisition for the Heidelberg Directorate of Engineering and Housing

    DTIC Science & Technology

    1991-01-01

    connected is also connected to a 3Com network, and the minicomputer is also wired to the LAN via Ethernet cable, faster Transmission Control Protocol ...internet Protocol (TCP/IP) file transfers to the minicomputer are an option. If the optional bar code wand, swipe reader, and employee badges are acquired...I] iI I 1II [LW I LLL-I dIL -F--iq ] ] i I rq-n-- m[ REQ 1D SERIALNo. FY TYPE FACILITY No SUFFIX COAP , TASK UNITS BLOCK 4 , ~~Eli M E H/AS~s ML]3

  3. International Biodefense Enhancement Capabilities from a Policy Perspective

    DTIC Science & Technology

    2005-05-01

    1 no debe inferirse ning6n tipo de aval oficial. 17 W8 I XWH-04-C-0006 Figure 4. Hospital Self-Assessment Tool Question 1, Spanish version 2...radiol6gico 4 3 2 1 E/NP Accidente en una central de energia 4 3 2 1 E/NP nuclear Detonaci6n de un dispositivo radiol6gico 4 3 2 1 E/NP en el...y planeamiento y fuente : W8 I XWH-04-C-0006 17. ,Ha utilizado su organizaci6n algfin otro programa de preparaci6n, ademds de los propuestos en la Gui

  4. Critical design aspects of dynamic titanium alloy risers

    SciTech Connect

    Baxter, C.F.; Schutz, R.W.

    1996-12-01

    Titanium alloys offer a unique, attractive combination of physical, mechanical, and corrosion properties for design of dynamic, compliant offshore risers. The Ti-6Al-4V ELI alloy, in a beta-transformed condition and with minor ruthenium or palladium additions for chloride resistance above 80 C, represent logical base-case metallic materials for compliant risers. All of the technology and components needed to produce a complete, viable titanium alloy compliant riser system, including pipe, termination designs, joining methods, and coatings are available, and are reviewed in this paper.

  5. Dynamic Young's moduli of space materials at low temperatures

    NASA Astrophysics Data System (ADS)

    Zhang, Z.; Zhao, L. Z.; Tu, Z. H.; Zhang, P. Q.

    Using vibration analysis methods, the dynamic mechanical properties of space materials at low temperatures (from 4.2 to 300 K) are studied in this paper. System identification techniques in the time domain are used to identify the dynamic parameters of the space materials Ti-5Al-2.5Sn extra-low-interstitial (ELI) alloy and Al-2.5Li-1.3Cu-0.9Mg-0.13Zr (Al-Li) alloy. The dynamic Young's moduli of these materials are calculated using the basic natural frequencies at different temperatures.

  6. Recycling Metchnikoff: Probiotics, the Intestinal Microbiome and the Quest for Long Life

    PubMed Central

    Mackowiak, Philip A.

    2013-01-01

    Over a century ago, Elie Metchnikoff theorized that health could be enhanced and senility delayed by manipulating the intestinal microbiome with host-friendly bacteria found in yogurt. His theory flourished for a time, then drifted to the fringe of medical practice before re-emerging in the mid-1990s as a concept worthy of mainstream medical attention. Metchnikoff also predicted the existence of bacterial translocation and anticipated theories linking chronic inflammation with the pathogenesis of atherosclerosis and other disorders of the aged. PMID:24350221

  7. Final Report on Contract N00014-92-C-0173 (Office of Naval Research)

    DTIC Science & Technology

    2001-01-10

    partially decoupled from the bulk as a result. 0 The number of molecules contributing to this feature is small P and was estimated to be one. This...are two such cones. One that 10 1 100 - opened into the surface and the other which opened away Water p (z) ELi. from the surface, which we call the...surface and bulk cones, "E respectively. To make the normalization explicit, g(r) is de- Sfined as 50 I d__4 g 2 o (n(r)), (4)4 -r~ p dr 2where n (r) is

  8. M-X Environmental Technical Report - Selection of Suitable Locational Alternatives.

    DTIC Science & Technology

    1980-12-01

    to the DDA. To the south of the proposed Dalhart site the terrain from the Punta Agua , Rita Blanca, and Canadian rivers becomes extremely erratic and...could be used to lessen potable water demands or could be used to recharge the local aquifer. 4-14 i m / I I III , ,- ,- H 04 -) 4"m4 ( NJ, 4-15) Wa...District to supply treated potable water by pipeline from Las Vegas.) In an overall assessment of water supply, each base location except Ely would

  9. International Conference on Surface Modification of Metals by Ion Beams Held in Riva Del Garda, Italy on 12-16 September 1988 (Final Program and Abstracts)

    DTIC Science & Technology

    1988-09-16

    Corrosion Properties Chairmen: P.L. Bonora, G.K. Wolf and P.G.Orsini 08:30 ElI Invited (dIon Beam Assisted Coatings ror Corrosion Studies*., W...FRG 12:40 E-9 a(Electrochemical and Corrosion Behaviour of BN Coated Aluminium Alloys Surace*, L. Fedrizzi. M. Elena, S. Gialanella, M. Dapor and L...Wu, I. Deszi and 0. Langouche, University of Leuven, Belgium F-8 -Structural and Electrical Studies of Vanadium Silicide Layers Synthesized by High

  10. M-X Environmental Technical Report. Indirect Effects Index for Impact Analysis.

    DTIC Science & Technology

    1980-12-22

    C-02 7 9. PERFORMING ORGANIZATION NAME AND ADDRESS 10. PROGRAM ELEMENT. PROJECT, TASK Henningson, Durham and Richardson AREA & WORK UNIT NUMBERS...and/or E E T Dist special MR3 18 ]BY 10 11DR SciencesD Sant Barbara, California 22 December 1980 IDISTRIBUTION STATEMENT A Approved fox public xeleasel...Milford 17,221 Ely 14,347 6 Milford 17,221 Coyote 12,195 3987 8 $ J Results The analysis is performed resource by resource. The tables generated by the

  11. Safe Underwater Electrical Power.

    DTIC Science & Technology

    1980-02-01

    identifed 22 models of earth- leakage circuit breakers (ELCBs) on the world market (Ref 5). When installed on the supply circuit, these devices...latch the breaker in the set position. When DC instead I,f AC is applied to the coil, an electromagnet is formed, aiding - 4P . pC 0nC 4-) ,o 4c 9> the...Heaton. D~enver CO BAI[1ELIE-COLU MBUS LABS (1). Hackrmi) Columbus. OH BECHTEL. CORP. SAN FRANCISCO. CA (PHEL.PS) BELGIUM HAFCON, N.V., Gent BRAND IND)US

  12. Implementation of a Model of Requisition Processing for the Ships Supply Support Study

    DTIC Science & Technology

    1973-10-23

    WILL bE OOh lEbl blAllbllG. 121 E=L(1) 12b FOK 1=1 IC K 130 IF LC1XE GO 10 UO 13b E=L(I) 140 iMEM I l^b...F = (E*(2t(l/2)))/((l/M+l/i\\2)T(l/^)) lbO FhIM "THE VALUE OF 1HE lEbl blAllbllG lbM,F lbl Ki-INI lb2 KK1M *’^hE^.EFt^.E

  13. Use of Computer Statistical Packages to Generate Quality Control Reports on Training

    DTIC Science & Technology

    1980-01-01

    dI NI 40MMY 6V 6locknIumibff) Training Data Processing Management Attitudes (Psychology) Computers Computer Applications Automation Computer Programs... processing and produces graphic displays very similar to quality control charts. [The output allows a ai4eeto fdvAn alp advmmnI. anaw. 4u OP W 3 on"" of...David W. Bessemer Acession Forand -- kF Brian L. Kottas Submitted by: ByDonald F. Haggard, Chief ByFORT KNOX FIELD UNIT r o:, A&1 1l.d/Qr sp a C i ELI

  14. Nonlinear effects in Thomson backscattering

    NASA Astrophysics Data System (ADS)

    Maroli, C.; Petrillo, V.; Tomassini, P.; Serafini, L.

    2013-03-01

    We analyze the nonlinear classical effects of the X/γ radiation produced by Thomson/Compton sources. We confirm the development of spectral fringes of the radiation on axis, which comports broadening, shift, and deformation of the spectrum. For the nominal parameters of the SPARC-LAB Thomson scattering and of the European Proposal for the gamma source ELI-NP, however, the radiation, when collected in the suitable acceptance angle, does not reveal many differences from that predicted by the linear model and the nonlinear redshift is subdominant with respect to the quantum recoil. An experiment aimed to the study of the nonlinearities is proposed on the SPARC-LAB source.

  15. Urban, Forest, and Agricultural AIS Data: Fine Spectral Structure

    NASA Technical Reports Server (NTRS)

    Vanderbilt, V. C.

    1985-01-01

    Spectra acquired by the Airborne Imaging Spectrometer (AIS) near Lafayette, IN, Ely, MN, and over the Stanford University campus, CA were analyzed for fine spectral structure using two techniques: the ratio of radiance of a ground target to the radiance of a standard and also the correlation coefficient of radiances at adjacent wavelengths. The results show ramp like features in the ratios. These features are due to the biochemical composition of the leaf and to the optical scattering properties of its cuticle. The size and shape of the ramps vary with ground cover.

  16. Preliminary results of sequential extraction experiments for selenium on mine waste and stream sediments from Vermont, Maine, and New Zealand

    USGS Publications Warehouse

    Piatak, N.M.; Seal, R.R.; Sanzolone, R.F.; Lamothe, P.J.; Brown, Z.A.

    2006-01-01

    We report the preliminary results of sequential partial dissolutions used to characterize the geochemical distribution of selenium in stream sediments, mine wastes, and flotation-mill tailings. In general, extraction schemes are designed to extract metals associated with operationally defined solid phases. Total Se concentrations and the mineralogy of the samples are also presented. Samples were obtained from the Elizabeth, Ely, and Pike Hill mines in Vermont, the Callahan mine in Maine, and the Martha mine in New Zealand. These data are presented here with minimal interpretation or discussion. Further analysis of the data will be presented elsewhere.

  17. Impact of normal-phase gradient elution in chiral chromatography: a novel, robust, efficient and rapid chiral screening procedure.

    PubMed

    de la Puente Luz, María; White, Craig T; Rivera-Sagredo, Alfonso; Reilly, John; Burton, Keith; Harvey, Georgina

    2003-01-03

    Novel normal-phase gradient systems have been employed for fast high-throughput chiral analyses of Discovery compounds in our research laboratories in Eli Lilly and Company. In this report, we describe an automated screening approach based on gradient elution, in order to achieve accurate enantiomeric excess determinations, and chiral separations when needed, in the shortest possible timeframe. Baseline resolution of enantiomers has been obtained for over 85% of the samples so tested. For the remaining cases, complete enantioseparation by isocratic optimisation is generally achieved in a single shot. This technique has been proven to be robust and is now standard operating procedure at our analytical research laboratories.

  18. Recognition of the geologic framework of porphyry deposits on ERTS-1 imagery

    NASA Technical Reports Server (NTRS)

    Wilson, J. C. (Principal Investigator)

    1973-01-01

    The author has identified the following significant results. Photointerpretation methods have been most successfully applied in the less vegetated test sites where several previously unknown geologic features have been recognized and known ones extended. Northwest mid-Tertiary faults in the ELY, Nevada area are observed to offset north-trending ranges and abruptly terminate older Mesozoic structures. In the Ray, Arizona area the observed patterns of fault and fracture systems appear to be related to the locations of known porphyry copper deposits. In the Tanacross, Alaska area a number of regional circular features observed may represent near surface intrusions and, therefore, permissive environments for copper porphyries.

  19. Dynamics of Rarefied Gas and Molecular Gas Dynamics.

    DTIC Science & Technology

    1983-08-25

    of plates. (3). Circle /circumference. (4). Ellipse. (5). Rhomb. (6). Rectangle. (7). Equilateral triangle. Page 13. Number Re;, was calculated in...w;owl- Fig. 69. Fig. 70. 4-0i * Fig. 71. DOG 83067301 PAGE 5 Page 33. ----- -eli 4 Fig. 72. Fg 4 I-E DOC =83067301 PAGE3?1 44-- Fig. 75...cylinder; the body, which consists of the hemisphere and the circle and arranged/located under the angle of attack; the body of that consisting of the

  20. 1994 Annual Tropical Cyclone Report

    DTIC Science & Technology

    1995-01-01

    10 5 10 05 0 0 1665 7 14 18 16 14 12 8 4 WIND ERRORS(KT) 00 12 24 36 48 72 SOPER TYPIKX)NMELISSA (26W) (~) 94090918 94091000 94091006 94091012 94091018...15 454 490 774 536 521 276 240 230 201 72 108 342 149 AVERAGE 28 72 122 171 241 339 # CASES 29 27 25 23 21 13 SOPER TYPHOON ORCHID (28W) DTG(Z...BOB-ee CAITLIN KATE -lin CHUCK CHUCK DOUG DUG DEANNA dee-AN-na ELLIE ELL-ee ELI EE-lye FRED FRED FAYE FAY GLADYS GLAD-iss GARY GAR-ee HARRY HAR-ee

  1. Comparative Response of Platelet fV and Plasma fV to Activated Protein C and Relevance to a Model of Acute Traumatic Coagulopathy

    DTIC Science & Technology

    2014-06-12

    promoting aPC generation by the fIIa TM complex while simultaneously inhibiting the activation of TAFI by fIIa TM [20]. This complexity of mechanisms ...activated) (DrotAA) is recombinant human aPC previously marketed for severe sepsis under the brand name Xigris (Eli Lilly, Indianapolis, IN); the median...Tewksbury, MA). Results were exported from SoftMax Pro 5.4.5 ( Molecular Devices) for analysis. The effects of purified aPC (Lot CC0118, Haematologic

  2. Drotrecogin alfa (activated)...a sad final fizzle to a roller-coaster party.

    PubMed

    Angus, Derek C

    2012-02-06

    Following the failure of PROWESS-SHOCK to demonstrate efficacy, Eli Lilly and Company withdrew drotrecogin alfa (activated) from the worldwide market. Drotrecogin was initially approved after the original trial, PROWESS, was stopped early for overwhelming efficacy. These events prompt consideration of both the initial approval decision and the later decision to withdraw. It is regrettable that the initial decision was made largely on a single trial that was stopped early. However, the decision to approve was within the bounds of normal regulatory practice and was made by many approval bodies around the world. Furthermore, the overall withdrawal rate of approved drugs remains very low. The decision to withdraw was a voluntary decision by Eli Lilly and Company and likely reflected key business considerations. Drotrecogin does have important biologic effects, and it is probable that we do not know how best to select patients who would benefit. Overall, there may still be a small advantage to drotrecogin alfa, even used non-selectively, but the costs of determining such an effect with adequate certainty are likely prohibitive, and the point is now moot. In the future, we should consider ways to make clinical trials easier and quicker so that more information can be available in a timely manner when considering regulatory approval. At the same time, more sophisticated selection of patients seems key if we are to most wisely test agents designed to manipulate the septic host response.

  3. Corrosion resistance and in vitro response of laser-deposited Ti-Nb-Zr-Ta alloys for orthopedic implant applications.

    PubMed

    Samuel, Sonia; Nag, Soumya; Nasrazadani, Seifollah; Ukirde, Vaishali; El Bouanani, Mohamed; Mohandas, Arunesh; Nguyen, Kytai; Banerjee, Rajarshi

    2010-09-15

    While direct metal deposition of metallic powders, via laser deposition, to form near-net shape orthopedic implants is an upcoming and highly promising technology, the corrosion resistance and biocompatibility of such novel metallic biomaterials is relatively unknown and warrants careful investigation. This article presents the results of some initial studies on the corrosion resistance and in vitro response of laser-deposited Ti-Nb-Zr-Ta alloys. These new generation beta titanium alloys are promising due to their low elastic modulus as well as due the fact that they comprise of completely biocompatible alloying elements. The results indicate that the corrosion resistance of these laser-deposited alloys is comparable and in some cases even better than the currently used commercially-pure (CP) titanium (Grade 2) and Ti-6Al-4V ELI alloys. The in vitro studies indicate that the Ti-Nb-Zr-Ta alloys exhibit comparable cell proliferation but enhanced cell differentiation properties as compared with Ti-6Al-4V ELI.

  4. Physics with gamma-beams and charged particle detectors: I) Nuclear structure II) Nuclear astrophysics

    NASA Astrophysics Data System (ADS)

    Gai, Moshe

    2015-02-01

    The Charged Particle Working Group (CPWG) is proposing to construct large area Silicon Strip Detector (SSD), a gas Time Projection Chamber detector read by an electronic readout system (eTPC) and a Bubble Chamber (BC) containing superheated high purity water to be used in measurements utilizing intense gamma-ray beams from the newly constructed ELI-NP facility at Magurele, Bucharest in Romania. We intend to use the SSD and eTPC detectors to address essential problems in nuclear structure physics, such as clustering and the many alpha-decay of light nuclei such as 12C and 16O . All three detectors (SSD, eTPC and BC) will be used to address central problems in nuclear astrophysics such as the astrophysical cross section factor of the 12C (α,γ) reaction and other processes central to stellar evolution. The CPWG intends to submit to the ELI-NP facility a Technical Design Report (TDR) for the proposed detectors.

  5. Distributed processing (DP) based e-beam lithography simulation with long range correction algorithm in e-beam machine

    NASA Astrophysics Data System (ADS)

    Ki, Won-Tai; Choi, Ji-Hyeon; Kim, Byung-Gook; Woo, Sang-Gyun; Cho, Han-Ku

    2008-05-01

    As the design rule with wafer process is getting smaller down below 50nm node, the specification of CDs on a mask is getting more tightened. Therefore, more tight and accurate E-Beam Lithography simulation is highly required in these days. However, in reality most of E-Beam simulation cases, there is a trade-off relationship between the accuracy and the simulation speed. Moreover, the necessity of full chip based simulation has been increasing in order to estimate more accurate mask CDs based on real process condition. Therefore, without consideration of long range correction algorithm such as fogging effect and loading effect correction in E-beam machine, it would be impossible and meaningless to pursue the full chip based simulation. In this paper, we introduce a breakthrough method to overcome the obstacles of E-Beam simulation. In-house E-beam simulator, ELIS (E-beam LIthography Simulator), has been upgraded to solve these problems. First, DP (Distributed Processing) strategy was applied to improve calculation speed. Secondly, the long range correction algorithm of E-beam machine was also applied to compute intensity of exposure on a full chip based (Mask). Finally, ELIS-DP has been evaluated possibility of expecting or analyzing CDs on full chip base.

  6. 3D reconstruction of nuclear reactions using GEM TPC with planar readout

    NASA Astrophysics Data System (ADS)

    Bihałowicz, Jan Stefan

    2015-02-01

    The research program of the Extreme Light Infrastructure - Nuclear Physics (ELI-NP) laboratory under construction in Magurele, Romania facilities the need of developing a gaseous active-target detector providing 3D reconstruction of charged products of nuclear reactions induced by gamma beam. The monoenergetic, high-energy (Eγ > 19 MeV) gamma beam of intensity 1013γ/s allows studying nuclear reactions in astrophysics. A Time Projection Chamber with crossed strip readout (eTPC) is proposed as one of the imaging detectors. The special feature of the readout electrode structure is a 2D reconstruction based on the information read out simultaneously from three arrays of strips that form virtual pixels. It is expected to reach similar spatial resolution as for pixel readout at largely reduced cost of electronics. The paper presents the current progress and first results of the small scale prototype TPC which is a one of implementation steps towards eTPC detector proposed in the Technical Design Report of Charged Particles Detection at ELI-NP.

  7. Subcritical crack growth of selected aerospace pressure vessel materials

    NASA Technical Reports Server (NTRS)

    Hall, L. R.; Bixler, W. D.

    1972-01-01

    This experimental program was undertaken to determine the effects of combined cyclic/sustained loads, stress level, and crack shape on the fatigue crack growth rate behavior of cracks subjected to plane strain conditions. Material/environment combinations tested included: 2219-T87 aluminum plate in gaseous helium, room air, and 3.5% NaCl solution at room temperature, liquid nitrogen, and liquid hydrogen; 5Al-2.5 Sn (ELI) titanium plate in liquid nitrogen and liquid hydrogen and 6AL-4V (ELI) STA titanium plate in gaseous helium and methanol at room temperature. Most testing was accomplished using surface flawed specimens instrumented with a clip gage to continuously monitor crack opening displacements at the specimen surface. Tapered double cantilever beam specimens were also tested. Static fracture and ten hour sustained load tests were conducted to determine fracture toughness and apparent threshold stress intensity values. Cyclic tests were performed using sinusoidal loading profiles at 333 MHz (20 cpm) and trapezoidal loading profiles at both 8.3 MHz (0.5 cpm) and 3.3 MHz (0.2 cpm). Data were evaluated using modified linear elastic fracture mechanics parameters.

  8. Plasma nitriding of titanium alloy: Effect of roughness, hardness, biocompatibility, and bonding with bone cement.

    PubMed

    Khandaker, Morshed; Riahinezhad, Shahram; Li, Yanling; Vaughan, Melville B; Sultana, Fariha; Morris, Tracy L; Phinney, Lucas; Hossain, Khalid

    2016-11-25

    Titanium (Ti) alloys have been widely used in orthopedics and orthodontic surgeries as implants because of their beneficial chemical, mechanical, and biological properties. Improvement of these properties of a Ti alloy, Ti-6Al-4V Eli, is possible by the use of plasma nitriding treatment on the Ti alloy. The novelty of this study is the evaluation of a DC glow discharge nitrogen plasma treatment method on the surface, mechanical and biological properties of Ti alloy. Specifically, this study measured the chemical states, roughness, hardness, and biocompatibility of plasma nitride treated Ti-6Al-4V Eli as well as determined the effect of plasma treatment on the fracture strength between the Ti alloy and bone clement. This study hypothesized that DC glow discharge nitrogen plasma treatment may alter the surface chemical and mechanical states of the Ti alloy that may influence the fracture strength of implant/cement interfaces under static load. This study found that plasma nitride treatment on Ti alloy does not have effect on the roughness and biocompatibility (P value > 0.5), but significantly effect on the hardness and fracture strength of Ti-bone cement interfaces compared to those values of untreated Ti samples (P value < 0.5). Therefore, the DC glow discharge nitrogen plasma treated Ti alloy can potentially be used for orthopedic applications.

  9. Pennsylvanian-Permian tectonism in the Great Basin: The Dry Mountain trough and related basins

    SciTech Connect

    Snyder, W.S.; Spinosa, C.; Gallegos, D.M. )

    1991-02-01

    Pennsylvanian-Permian tectonism affected the continental margin of western North America from the Yukon to the Mojave Desert. Specific signatures of this tectonism include local angular unconformities, regional disconformities, renewed outpouring of clastic debris from a reactivated Antler and related highlands, and development of deeper water basins with anoxic sediments deposited below wave base. The basins formed include Ishbel trough (Canada), the Wood River basin (Idaho), Cassia basin, Ferguson trough, Dry Mountain trough (all Nevada), and unnamed basins in Death Valley-Mojave Desert region. The Dry Mountain trough (DMT) was initiated during early Wolfcampian and received up to 1,200 m of sediment by the late Leonardian. The lower contact is a regional unconformity with the Ely Limestone, or locally with the Diamond Peak or Vinini formations. Thus, following a period of localized regional uplift that destroyed the Ely basin, portions of the uplifted and exposed shelf subsided creating the Dry Mountain trough. Evidence suggesting a tectonic origin for the DMT includes (1) high subsidence rates (60-140 m/m.y.); (2) renewed influx of coarse clastic debris from the Antler highlands: (3) possible pre-Early Permian folding, thrusting, and tilting within the highlands; and (4) differential subsidence within the Dry Mountain trough, suggesting the existence of independent fault blocks.

  10. The ELIMED transport and dosimetry beamline for laser-driven ion beams

    NASA Astrophysics Data System (ADS)

    Romano, F.; Schillaci, F.; Cirrone, G. A. P.; Cuttone, G.; Scuderi, V.; Allegra, L.; Amato, A.; Amico, A.; Candiano, G.; De Luca, G.; Gallo, G.; Giordanengo, S.; Guarachi, L. Fanola; Korn, G.; Larosa, G.; Leanza, R.; Manna, R.; Marchese, V.; Marchetto, F.; Margarone, D.; Milluzzo, G.; Petringa, G.; Pipek, J.; Pulvirenti, S.; Rizzo, D.; Sacchi, R.; Salamone, S.; Sedita, M.; Vignati, A.

    2016-09-01

    A growing interest of the scientific community towards multidisciplinary applications of laser-driven beams has led to the development of several projects aiming to demonstrate the possible use of these beams for therapeutic purposes. Nevertheless, laser-accelerated particles differ from the conventional beams typically used for multiscipilinary and medical applications, due to the wide energy spread, the angular divergence and the extremely intense pulses. The peculiarities of optically accelerated beams led to develop new strategies and advanced techniques for transport, diagnostics and dosimetry of the accelerated particles. In this framework, the realization of the ELIMED (ELI-Beamlines MEDical and multidisciplinary applications) beamline, developed by INFN-LNS (Catania, Italy) and that will be installed in 2017 as a part of the ELIMAIA beamline at the ELI-Beamlines (Extreme Light Infrastructure Beamlines) facility in Prague, has the aim to investigate the feasibility of using laser-driven ion beams for multidisciplinary applications. In this contribution, an overview of the beamline along with a detailed description of the main transport elements as well as the detectors composing the final section of the beamline will be presented.

  11. Laser-accelerated ion beam diagnostics with TOF detectors for the ELIMED beam line

    NASA Astrophysics Data System (ADS)

    Milluzzo, G.; Scuderi, V.; Amico, A. G.; Borghesi, M.; Cirrone, G. A. P.; Cuttone, G.; De Napoli, M.; Doria, D.; Dostal, J.; Larosa, G.; Leanza, R.; Margarone, D.; Petringa, G.; Pipek, J.; Romagnani, L.; Romano, F.; Schillaci, F.; Velyhan, A.

    2017-02-01

    Laser-accelerated ion beams could represent the future of particle acceleration in several multidisciplinary applications, as for instance medical physics, hadrontherapy and imaging field, being a concrete alternative to old paradigm of acceleration, characterized by huge and complex machines. In this framework, following on from the ELIMED collaboration, launched in 2012 between INFN-LNS and ELI-Beamlines, in 2014 a three-years contract has been signed between the two institutions for the design and the development of a complete transport beam-line for high-energy ion beams (up to 60 MeV) coupled with innovative diagnostics and in-air dosimetry devices. The beam-line will be installed at the ELI-Beamlines facility and will be available for users. The measurement of the beam characteristics, such as energy spectra, angular distributions and dose-rate is mandatory to optimize the transport as well as the beam delivery at the irradiation point. In order to achieve this purpose, the development of appropriate on-line diagnostics devices capable to detect high-pulsed beams with high accuracy, represents a crucial point in the ELIMED beamline development. The diagnostics solution, based on the use of silicon carbide (SiC) and diamond detectors using TOF technique, will be presented together with the preliminary results obtained with laser-accelerated proton beams.

  12. Polarization of x-gamma radiation produced by a Thomson and Compton inverse scattering

    NASA Astrophysics Data System (ADS)

    Petrillo, V.; Bacci, A.; Curatolo, C.; Drebot, I.; Giribono, A.; Maroli, C.; Rossi, A. R.; Serafini, L.; Tomassini, P.; Vaccarezza, C.; Variola, A.

    2015-11-01

    A systematic study of the polarization of x-gamma rays produced in Thomson and Compton scattering is presented, in both classical and quantum schemes. Numerical results and analytical considerations let us to establish the polarization level as a function of acceptance, bandwidth and energy. Few sources have been considered: the SPARC_LAB Thomson device, as an example of a x-ray Thomson source, ELI-NP, operating in the gamma range. Then, the typical parameters of a beam produced by a plasma accelerator has been analyzed. In the first case, with bandwidths up to 10%, a contained reduction (<10 % ) in the average polarization occurs. In the last case, for the nominal ELI-NP relative bandwidth of 5 ×1 0-3 , the polarization is always close to 1. For applications requiring larger bandwidth, however, a degradation of the polarization up to 30% must be taken into account. In addition, an all optical gamma source based on a plasma accelerated electron beam cannot guarantee narrow bandwidth and high polarization operational conditions required in nuclear photonics experiments.

  13. Radiation damping induced electron trapping and positron creation

    NASA Astrophysics Data System (ADS)

    Gu, Yanjun; Klimo, Ondrej; Weber, Stefan; Korn, Georg

    2016-10-01

    High power laser facilities with intensities up to 1022 W /cm2 have been realized and the forthcoming installations are expected to reach 10 22 - 24 W /cm2 or even higher. At these intensities, the radiation effects and quantum electrodynamics description come into play. The emitted photon momentum becomes comparable to the momentum of the emitting electrons. In this work, we propose a regime of electron self-injection and trapping in the ultra-high intensity laser-plasma interaction. The electrons accumulated at the head of the laser pulse are injected into the pulse centre due to the strong longitudinal electrostatic field created by the high density shell. These electrons, which experience a restoring force provided by the emitted photons, can be confined in the laser pulse for a long time. The corresponding photons are produced in the region where the laser field is strong. High energy and well collimated positron bunches are produced. This regime may be beneficial for the potential experiments to be carried out on large laser facilities such as ELI. This work was supported by the project ELI: Extreme Light Infrastructure (CZ.02.1.01/0.0/0.0/15_008/0000162) from European Regional Development.

  14. Characterization and analysis of surface notches on Ti-alloy plates fabricated by additive manufacturing techniques

    NASA Astrophysics Data System (ADS)

    Chan, Kwai S.

    2015-12-01

    Rectangular plates of Ti-6Al-4V with extra low interstitial (ELI) were fabricated by layer-by-layer deposition techniques that included electron beam melting (EBM) and laser beam melting (LBM). The surface conditions of these plates were characterized using x-ray micro-computed tomography. The depth and radius of surface notch-like features on the LBM and EBM plates were measured from sectional images of individual virtual slices of the rectangular plates. The stress concentration factors of individual surface notches were computed and analyzed statistically to determine the appropriate distributions for the notch depth, notch radius, and stress concentration factor. These results were correlated with the fatigue life of the Ti-6Al-4V ELI alloys from an earlier investigation. A surface notch analysis was performed to assess the debit in the fatigue strength due to the surface notches. The assessment revealed that the fatigue lives of the additively manufactured plates with rough surface topographies and notch-like features are dominated by the fatigue crack growth of large cracks for both the LBM and EBM materials. The fatigue strength reduction due to the surface notches can be as large as 60%-75%. It is concluded that for better fatigue performance, the surface notches on EBM and LBM materials need to be removed by machining and the surface roughness be improved to a surface finish of about 1 μm.

  15. Hydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants

    NASA Astrophysics Data System (ADS)

    Wales, Thomas E.; Poe, Jerrod A.; Emert-Sedlak, Lori; Morgan, Christopher R.; Smithgall, Thomas E.; Engen, John R.

    2016-06-01

    Hydrogen exchange mass spectrometry can be used to compare the conformation and dynamics of proteins that are similar in tertiary structure. If relative deuterium levels are measured, differences in sequence, deuterium forward- and back-exchange, peptide retention time, and protease digestion patterns all complicate the data analysis. We illustrate what can be learned from such data sets by analyzing five variants (Consensus G2E, SF2, NL4-3, ELI, and LTNP4) of the HIV-1 Nef protein, both alone and when bound to the human Hck SH3 domain. Regions with similar sequence could be compared between variants. Although much of the hydrogen exchange features were preserved across the five proteins, the kinetics of Nef binding to Hck SH3 were not the same. These observations may be related to biological function, particularly for ELI Nef where we also observed an impaired ability to downregulate CD4 surface presentation. The data illustrate some of the caveats that must be considered for comparison experiments and provide a framework for investigations of other protein relatives, families, and superfamilies with HX MS.

  16. Design of the ELIMAIA ion collection system

    NASA Astrophysics Data System (ADS)

    Schillaci, F.; Cirrone, G. A. P.; Cuttone, G.; Maggiore, M.; Andó, L.; Amato, A.; Costa, M.; Gallo, G.; Korn, G.; Larosa, G.; Leanza, R.; Manna, R.; Margarone, D.; Milluzzo, G.; Pulvirenti, S.; Romano, F.; Salamone, S.; Sedita, M.; Scuderi, V.; Tramontana, A.

    2015-12-01

    A system of permanent magnet quadrupoles (PMQs) is going to be realized by INFN-LNS to be used as a collection system for the injection of laser driven ion beams up to 60 MeV/u in an energy selector based on four resistive dipoles. This system is the first element of the ELIMED (ELI-Beamlines MEDical and Multidisciplinary applications) beam transport, dosimetry and irradiation line that will be developed by INFN-LNS (It) and installed at the ELI-Beamlines facility in Prague (Cz). ELIMED will be the first user's open transport beam-line where a controlled laser-driven ion beam will be used for multidisciplinary researches. The definition of well specified characteristics, both in terms of performances and field quality, of the magnetic lenses is crucial for the system realization, for the accurate study of the beam dynamics and for the proper matching with the magnetic selection system which will be designed in the next months. Here, we report the design of the collection system and the adopted solutions in order to realize a robust system form the magnetic point of view. Moreover, the first preliminary transport simulations are also described.

  17. Impact of Cn2 profile on tomographic reconstruction performance: application to E-ELT wide field AO systems

    NASA Astrophysics Data System (ADS)

    Costille, A.; Fusco, T.

    2012-07-01

    New techniques of Adaptive Optics (AO), generically called Wide Field AO, have been developed in the frame of the design study for new instruments for Extremely Large Telescopes (ELI). Concepts such as Multi-Conjugate AO are based on a tomographic reconstruction of the turbulent volume followed by a projection onto DM(s) in order to ensure a good correction in a large Field of View. These systems require a 3D phase reconstruction and a statistical representation of the turbulent volume through the knowledge of the Cn2 profile, which has a strong impact on performance. We focus our study on the analysis of the impact of the structure and the parameters, which define the Cn2 profile, on the performance of a given tomographic system for an ELI. In this article, we perform simulation to emphasize the terms which are directly linked to the knowledge of the true input Cn2 profile, which simulates the input turbulent perturbations, and to the Cn2 profile which is used as a model in the reconstruction process. We determine and discuss the level of the accuracy needed on the Cn2 profile to limit the tomographic error term and to ensure a good performance. We show that a good sampling of the input turbulence is required to ensure performance of the system.

  18. ISIS-3521. Isis Pharmaceuticals.

    PubMed

    Li, K; Zhang, J

    2001-10-01

    ISIS-3521 is a 20-mer antisense phosphorothioate oligonucleotide PKCa expression inhibitor, under development by Isis (formerly in collaboration with Novartis) for the potential treatment of solid tumors that are refractory to, or recurrent with, standard treatment regimens [175741]. In November 1999, Novartis announced that it would end its codevelopment of ISIS-3521 [348221], [348222]. In August 2001, Eli Lilly in-licensed ISIS-3521 [420062]. In October 2000, phase III trials of ISIS-3521, in combination with carboplatin and paclitaxel, were initiated for the treatment of non-small cell lung cancer (NSCLC) [386128]. The FDA granted ISIS-3521 Fast Track review status for NSCLC in November 2000 [388930]. In April 2001, Bear Sterns & Co predicted US approval of ISIS-3521 in 2002 [411081]. In August 2001, Eli Lilly and Isis entered into a four-year strategic alliance that includes ISIS-3521. For the license of ISIS-3521, Isis will receive $25 million in upfront fees and will be reimbursed for remaining phase III development and registration costs [420062].

  19. Surface modification by alkali and heat treatments in titanium alloys.

    PubMed

    Lee, Baek-Hee; Do Kim, Young; Shin, Ji Hoon; Hwan Lee, Kyu

    2002-09-05

    Pure titanium and titanium alloys are normally used for orthopedic and dental prostheses. Nevertheless, their chemical, biological, and mechanical properties still can be improved by the development of new preparation technologies. This has been the limiting factor for these metals to show low affinity to living bone. The purpose of this study is to improve the bone-bonding ability between titanium alloys and living bone through a chemically activated process and a thermally activated one. Two kinds of titanium alloys, a newly designed Ti-In-Nb-Ta alloy and a commercially available Ti-6Al-4V ELI alloy, were used in this study. In this study, surface modification of the titanium alloys by alkali and heat treatments (AHT), alkali treated in 5.0M NaOH solution, and heat treated in vacuum furnace at 600 degrees C, is reported. After AHT, the effects of the AHT on the bone integration property were evaluated in vitro. Surface morphologies of AHT were observed by optical microscopy (OM) and scanning electron microscopy (SEM). Chemical compositional surface changes were investigated by X-ray diffractometry (XRD), energy dispersive spectroscopy (EDS), and auger electron spectroscopy (AES). Titanium alloys with surface modification by AHT showed improved bioactive behavior, and the Ti-In-Nb-Ta alloy had better bioactivity than the Ti-6Al-4V ELI alloy in vitro.

  20. TOF technique for laser-driven proton beam diagnostics for the ELIMED beamline

    NASA Astrophysics Data System (ADS)

    Milluzzo, G.; Scuderi, V.; Amico, A. G.; Cirrone, G. A. P.; Cuttone, G.; De Napoli, M.; Dostal, J.; Larosa, G.; Leanza, R.; Margarone, D.; Petringa, G.; Pipek, J.; Romano, F.; Schillaci, F.; Velyhan, A.

    2017-03-01

    The Time of Flight (TOF) method for laser-driven ion beam diagnostics has been extensively investigated so far for low energy ion diagnostics and several works, reported in literature [1,2], have shown its efficiency in the measurement of particle beam characteristics such as ion species, energy spectrum and current. Moreover, such technique allows obtaining a shot-to-shot on-line monitoring of optically accelerated particles, necessary to control the reproducibility of the accelerated beam and to deliver a beam suitable for any kind of applications. For this reason, the ELIMED beamline [3,4], which will be entirely developed at INFN-LNS and installed in 2017 within the ion beamline ELIMAIA (ELI Multidisciplinary Applications of laser-Ion Acceleration) experimental hall at ELI-Beamlines in Prague, will be equipped with an on-line diagnostics system composed by silicon carbide and diamond detectors, using the TOF technique. In this contribution, the procedure developed for TOF signal analysis will be briefly reported.

  1. The Development of Titanium Alloys for Application in the Space Shuttle Main Engine

    NASA Technical Reports Server (NTRS)

    Halchak, John A.; Jerman, Gregory A.; Zimmerman, Frank R.

    2010-01-01

    The high-strength-to-weight ratio of titanium alloys, particularly at cryogenic temperatures, make them attractive for application in rocket engines - offering the potential of superior performance while minimizing component weight. This was particularly attractive for rotating components, such as pump impellers, where titanium alloys presented the potential to achieve a major advance in rotational tip speed, with a reduction in stages and resultant saving in pump weight and complexity. The investigation into titanium alloys for application in cryogenic turbopumps began in the early 1960's. However, it was found that the reactivity of titanium limited applications and produced unique processing challenges. Specialized chemical compositions and processing techniques had to be developed. A substantial amount of material properties testing and trials in experimental turbopumps occurred, ultimately leading to application in the Space Shuttle Main Engine. One particular alloy stood out for use at liquid hydrogen temperatures, Ti-5Al-2.5Sn ELI. This alloy was employed for several critical components. This presentation deals with the development effort, the challenges that were encountered and operational experiences with Ti-5Al-2.5Sn ELI in the SSME.

  2. Extreme Light Infrastructure: nuclear physics

    NASA Astrophysics Data System (ADS)

    Zamfir, N. V.; Habs, D.; Negoita, F.; Ursescu, D.

    2011-06-01

    The spectacular progress of electron and heavy-ions acceleration driven by ultra-short high-power laser has opened the way for new methods of investigations in nuclear physics and related fields. On the other hand, upshifting the photon energies of a high repetition TW-class laser through inverse Compton scattering on electron bunches classically accelerated, a high-flux narrow bandwidth gamma beam can be produced. With such a gamma beam in the 1-20 MeV energy range and a two-arms 10-PW class laser system, the pillar of "Extreme Light Infrastructure" to be built in Bucharest will focus on nuclear phenomena and their practical applications. Nuclear structure, nuclear astrophysics, fundamental QED aspects as well as applications in material and life sciences, radioactive waste management and homeland security will be studied using the high-power laser, the gamma beam or combining the two. The article includes a general description of ELI-Nuclear Physics (ELI-NP) facility, an overview of the Physics Case and some details on the few, most representative proposed experiments.

  3. 3D reconstruction of nuclear reactions using GEM TPC with planar readout

    SciTech Connect

    Bihałowicz, Jan Stefan

    2015-02-24

    The research program of the Extreme Light Infrastructure – Nuclear Physics (ELI-NP) laboratory under construction in Magurele, Romania facilities the need of developing a gaseous active-target detector providing 3D reconstruction of charged products of nuclear reactions induced by gamma beam. The monoenergetic, high-energy (E{sub γ} > 19 MeV) gamma beam of intensity 10{sup 13}γ/s allows studying nuclear reactions in astrophysics. A Time Projection Chamber with crossed strip readout (eTPC) is proposed as one of the imaging detectors. The special feature of the readout electrode structure is a 2D reconstruction based on the information read out simultaneously from three arrays of strips that form virtual pixels. It is expected to reach similar spatial resolution as for pixel readout at largely reduced cost of electronics. The paper presents the current progress and first results of the small scale prototype TPC which is a one of implementation steps towards eTPC detector proposed in the Technical Design Report of Charged Particles Detection at ELI-NP.

  4. Physics with gamma-beams and charged particle detectors: I) Nuclear structure II) Nuclear astrophysics

    SciTech Connect

    Gai, Moshe

    2015-02-24

    The Charged Particle Working Group (CPWG) is proposing to construct large area Silicon Strip Detector (SSD), a gas Time Projection Chamber detector read by an electronic readout system (eTPC) and a Bubble Chamber (BC) containing superheated high purity water to be used in measurements utilizing intense gamma-ray beams from the newly constructed ELI-NP facility at Magurele, Bucharest in Romania. We intend to use the SSD and eTPC detectors to address essential problems in nuclear structure physics, such as clustering and the many alpha-decay of light nuclei such as {sup 12}C and {sup 16}O. All three detectors (SSD, eTPC and BC) will be used to address central problems in nuclear astrophysics such as the astrophysical cross section factor of the {sup 12}C(α,γ) reaction and other processes central to stellar evolution. The CPWG intends to submit to the ELI-NP facility a Technical Design Report (TDR) for the proposed detectors.

  5. How do electron localization functions describe π-electron delocalization?

    PubMed

    Steinmann, Stephan N; Mo, Yirong; Corminboeuf, Clemence

    2011-12-14

    Scalar fields provide an intuitive picture of chemical bonding. In particular, the electron localization function (ELF) has proven to be highly valuable in interpreting a broad range of bonding patterns. The discrimination between enhanced or reduced electron (de)localization within cyclic π-conjugated systems remains, however, challenging for ELF. In order to clearly distinguish between the local properties of ten highly and weakly π-(de)localized prototype systems, we compare the ELFs of both the canonical wave functions and electron-localized states (diabatic) with those of two closely related scalar fields: the electron localizability indicator (ELI-D) and the localized orbital locator (LOL). The simplest LOL function distinguishes enhanced from weak π-(de)localization in an insightful and reliable manner. LOL offers the finest contrast between annulenes with 4n/4n + 2 π electrons and their inorganic analogues as well as between hyperconjugated cyclopentadiene derivatives. LOL(π) also gives an appealing and intuitive picture of the π-bond. In contrast, the most popular ELF fails to capture subtle contrasting local electronic properties and suffers from the arbitrariness of the σ/π dissection. The orbital separation of the most recent ELI-D is clear-cut but the interpretations sometime less straightforward in the present context.

  6. Terbinafine hydrochloride nanovesicular gel: In vitro characterization, ex vivo permeation and clinical investigation.

    PubMed

    AbdelSamie, Sara M; Kamel, Amany O; Sammour, Omaima A; Ibrahim, Shady M

    2016-06-10

    In this work, nanovesicular chitosan gels were prepared for dermal delivery of terbinafine hydrochloride (TBN HCl). Ethosomes and vesicles containing different types of penetration enhancers (PEs) viz. Terpenes (cineole and limonene), labrasol and transcutol were developed. The prepared vesicles were evaluated for physical characteristics as well as skin interaction. The selected vesicles were incorporated into chitosan gel. An in vivo animal study was done on rat induced superficial Candida infection model. Moreover, randomized double blind clinical study was done on patients to compare the effect of the selected nanovesicular gel against the market product. Results showed the formation of nearly spherical, mostly deformable vesicular systems with size range of 95.5-530nm, zeta potential range of -0.1 to 15mV and entrapment efficiency range of 20-96.7%. Penetration enhancer vesicles (PEVs) prepared with 4% limonene (ELI4) showed the highest percent of drug deposition in the skin (53%) and the highest local accumulation efficiency value (35.3). In vivo animal study showed that the lowest fungal burden produced with ELI4 chitosan gel. Clinical studies showed cure rate of 86% within 7days treatment in case of limonene nanovesicular gel compared to 20% for market product (Lamisil® cream).

  7. MRSA Pediatric clone expressing ermC plus lnuA genes causing nosocomial transmission and healthcare workers colonization in a neonatal intensive care unit.

    PubMed

    Faccone, Diego; Togneri, Ana M; Podesta, Laura; Perez, Marcela; Gagetti, Paula; Sanchez, Susana; Romero, Graciela; Corso, Alejandra

    2014-07-01

    Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of both nosocomial and community-acquired infections. We describe an outbreak caused by the MRSA Pediatric clone expressing an unusual lincosamide resistant phenotype. Between January and May 2006, an MRSA outbreak was detected at the Neonatal Unit of Hospital Interzonal General de Agudos "Evita", Buenos Aires Province, Argentina that affected ten patients. Seven isolates from seven patients plus five MRSA recovered from health care workers (nasal carriage) were studied. Two phenotypes were observed: (i) ELCi (10), resistance to erythromycin and lincomycin and inducible resistance to clindamycin; (ii) ELiCi (2), resistance to erythromycin and inducible resistance to lincomycin and clindamycin. All 12 MRSA were resistant to oxacillin, erythromycin and gentamicin. Isolates expressing the ELCi-phenotype showed lincomycin MIC values between 16 and 32mg/L, while the remaining 2 isolates with ELiCi-phenotype presented a MIC value of 0.5mg/L. No differences were observed between the clindamycin MIC values in both phenotypes, ranging 0.25-0.5mg/L. Isolates showing ELCi-phenotype harbored ermC plus lnuA genes, and the other two only ermC gene. All 12 isolates were genetically related and belonged to the Pediatric clone (ST100) harboring a new variant of SCCmecIV. This is the first MRSA outbreak expressing an unusual ELCi phenotype due to a combination of ermC plus lnuA genes.

  8. Human insulin prepared by recombinant DNA techniques and native human insulin interact identically with insulin receptors.

    PubMed Central

    Keefer, L M; Piron, M A; De Meyts, P

    1981-01-01

    Human insulin synthesized from A and B chains separately produced in Escherichia coli from cloned synthetic genes (prepared by the Eli Lilly Research Laboratories, Indianapolis, IN) was characterized by examining its interaction with human cultured lymphocytes, human circulating erythrocytes in vitro, and isolated rat fat cells. The binding behavior of the biosynthetic insulin with human cells was indistinguishable from that of native human or porcine insulins, with respect to affinity, association and dissociation kinetics, negative cooperativity, and the down-regulation of lymphocyte receptors. Similarly, the biosynthetic insulin was as potent as the native insulins in stimulating lipogenesis in isolated rat fat cells. We also examined the receptor binding characteristics of 125I-labeled human and porcine insulins monoiodinated solely at Tyr-A14, which were obtained by means of high-performance liquid chromatography of the iodination reaction mixture (this material was prepared by B. Frank, Eli Lilly Research Laboratories). In all aspects studied, the pure [TyrA14-125I]iodoinsulins were superior as tracers to the monoiodoinsulin purified by the more conventional method of gel filtration. PMID:7015337

  9. Chemical bonding analysis and properties of La{sub 7}Os{sub 4}C{sub 9}-A new structure type containing C- and C{sub 2}-units as Os-coordinating ligands

    SciTech Connect

    Dashjav, Enkhtsetseg; Prots, Yurii; Kreiner, Guido; Schnelle, Walter; Wagner, Frank R. Kniep, Ruediger

    2008-11-15

    The new ternary carbide La{sub 7}Os{sub 4}C{sub 9} was prepared by argon arc-melting of the elements followed by subsequent heat treatment at 900 deg. C for 250 h. The compound crystallizes monoclinic, in the space group C2/m (a=1198.5(2) pm, b=542.0(1) pm, c=1196.2(2) pm, {beta}=111.04(1){sup o}, V=725.2(2)x10{sup 6} pm{sup 3}, Z=2). The structure was determined from single crystal X-ray diffraction data and refined to a residual of R{sub 1}=0.02 (wR{sub 2}=0.03) for 4812 unique reflections and 64 variable parameters. Electrical resistivity and magnetic susceptibility measurements characterize the compound as a Pauli-paramagnetic metal. The crystal structure contains bridging C- and terminal C{sub 2}-units as Os-coordinating ligands, thereby forming polyanions {sub {infinity}}{sup 1}[Os{sub 4}(C{sub 2}){sub 2}C{sub 5}] running along the [101] direction. The polyanions are composed of alternating Os(C{sub 2})C{sub 2} and OsC{sub 3} units with the transition metal in distorted trigonal planar coordination. Charge compensation is ensured by La cations which are situated in-between the polyanions. The carbon-carbon bond (131 pm) within the C{sub 2} pairs is slightly shorter than the value of a common C-C double bond, and is discussed on the basis of COHP curves on the one side, and with ELI-D and electron density distributions on the other side. The method of partial ELI-D decomposition is shown to be well suited for the characterization of separated DOS structures in terms of chemical bonding signatures provided by ELI-D. The Os-La interactions are shown to be of a polar multicenter-bonding type with Os playing the role of the electron donor. Compared to an acetylide the C{sub 2} species were found to possess a significantly reduced bond order and an enhanced number of electrons in lone pair type spatial regions. This type of species cannot be simply classified in terms of model pictures such as C{sub 2}{sup 2-} and C{sub 2}{sup 4-}, respectively. - Graphical

  10. From laser particle acceleration to the synthesis of extremely neutron rich isotopes via the novel fission-fusion mechanism

    SciTech Connect

    Thirolf, P. G.

    2015-02-24

    High-power, short pulse lasers have emerged in the last decade as attractive tools for accelerating charged particles (electrons, ions) to high energies over mm-scale acceleration lengths, thus promising to rival conventional acceleration techniques in the years ahead. In the first part of the article, the principles of laser-plasma interaction as well as the techniques and the current status of the acceleration of electron and ion beams will be briefly introduced. In particular with the upcoming next generation of multi-PW class laser systems, such as the one under construction for the ELI-Nuclear Physics project in Bucharest (ELI-NP), very efficient acceleration mechanisms for brilliant ion beams like radiation pressure acceleration (RPA) come into reach. Here, ultra-dense ion beams reaching solid-state density can be accelerated from thin target foils, exceeding the density of conventionally accelerated ion beams by about 14 orders of magnitude. This unique property of laser-accelerated ion beams can be exploited to explore the scenario of a new reaction mechanism called ‘fission-fusion’, which will be introduced in the second part of the article. Accelerating fissile species (e.g. {sup 232}Th) towards a second layer of the same material will lead to fission both of the beam-like and target-like particles. Due to the close to solid-state density of the accelerated ion bunches, fusion may occur between neutron-rich (light) fission products. This may open an access path towards extremely neutron-rich nuclides in the vicinity of the N=126 waiting point of the astrophysical r process. ‘Waiting points’ at closed nucleon shells play a crucial role in controlling the reaction rates. However, since most of the pathway of heavy-element formation via the rapid-neutron capture process (r-process) runs in ‘terra incognita’ of the nuclear landscape, in particular the waiting point at N=126 is yet unexplored and will remain largely inaccessible to conventional

  11. Effect of expertise on postmaximal long sprint blood metabolite responses.

    PubMed

    Hanon, Christine; Rabate, Mathieu; Thomas, Claire

    2011-09-01

    The aim of this study was to describe and compare the blood metabolic responses obtained after a single maximal exercise in elite and less-successful athletes and to investigate whether these responses are related to sprint performance. Eleven elite (ELI) and 14 regional (REG) long sprint runners performed a 300-m running test as fast as possible. Blood samples were taken at rest and at 4 minutes after exercise for measurements of blood lactate concentration [La] and acid-base status. The blood metabolic responses of ELI subjects compared to those of REG subjects for pH (7.07 ± 0.05 vs. 7.14 ± 1.5), sodium bicarbonate concentration ([HCO(3)(-)], 8.1 ± 1.5 vs. 9.8 ± 1.8 mmol·L(-1)), hemoglobin O(2) saturation (SaO(2)) (94.7 ± 1.8 vs. 96.2 ± 1.6%) were significantly lower (p < 0.05), and [La] was significantly higher in ELI (21.1 ± 2.9 vs. 19.1 ± 1.2 mmol·L(-1), p < 0.05). The 300-m performance (in % world record) was negatively correlated with pH (r = -0.55, p < 0.01), SaO2 (r = -0.64, p < 0.001), [HCO(3)(-)] (r = -0.40, p < 0.05), and positively correlated with [La] (r = 0.44, p < 0.05). In conclusion, for the same quantity of work, the best athletes are able to strongly alter their blood acid-base balance compared to underperforming runners, with larger acidosis and lactate accumulation. To obtain the pH limits with acute maximal exercise, coaches must have their athletes perform a distance run with duration of exercise superior to 35 seconds. The blood lactate accumulation values (mmol·L(-1)·s(-1)) recorded in this study indicate that the maximal glycolysis rate obtained in the literature from short sprint distances is maintained, but not increased, until 35 seconds of exercise.

  12. Experimental investigation of quasistatic and dynamic fracture properties of titanium alloys

    NASA Astrophysics Data System (ADS)

    Anderson, David Deloyd

    2002-09-01

    The goal of this work is to investigate the quasistatic and dynamic fracture properties of three titanium alloys: 6Al-4V titanium, 6Al-4V titanium ELI, and Timetal 5111. While standard tests exist for measuring quasistatic fracture toughness, the dynamic investigation requires that several measurement techniques are employed including Coherent Gradient Sensing (CGS), Crack Opening Displacement (COD), and the use of strain gages. The use of these methods with difficult engineering materials in the dynamic loading regime requires methodologies to be advanced beyond that previously required with model materials having properties ideal for experimental measurements techniques. After a description of each measurement technique is given, stress intensity factor measurements made on 12.7 mm thick pre-cracked 6Al-4V titanium specimens are compared. These specimens were dynamically impacted in three point bend in a drop weight tower. Specimens with and without side-grooves were tested as each measurement technique allows. Resulting stress intensity factor-time histories from the different techniques are compared to verify that their results mutually agree. Advancements in employing CGS, a shearing interferometric technique, are described in more detail. First, the analysis of CGS interferograms is extended to allow experimental fringe data to be fit to very general analytical asymptotic crack tip solution to determine mixed mode stress intensity factors. As formulated in this work, the CGS technique can be used to measure stress intensity factors for non-uniformly propagating dynamic mixed mode cracks moving along arbitrary paths in homogeneous linear elastic isotropic materials. Other advancements are also detailed which improve analysis accuracy, objectivity, and efficiency. Finally, with the equivalence of the three measurement technique results established, tests were performed on 8--17 mm thick pre-cracked three point bend specimens of the three materials to measure

  13. From laser particle acceleration to the synthesis of extremely neutron rich isotopes via the novel fission-fusion mechanism

    NASA Astrophysics Data System (ADS)

    Thirolf, P. G.

    2015-02-01

    High-power, short pulse lasers have emerged in the last decade as attractive tools for accelerating charged particles (electrons, ions) to high energies over mm-scale acceleration lengths, thus promising to rival conventional acceleration techniques in the years ahead. In the first part of the article, the principles of laser-plasma interaction as well as the techniques and the current status of the acceleration of electron and ion beams will be briefly introduced. In particular with the upcoming next generation of multi-PW class laser systems, such as the one under construction for the ELI-Nuclear Physics project in Bucharest (ELI-NP), very efficient acceleration mechanisms for brilliant ion beams like radiation pressure acceleration (RPA) come into reach. Here, ultra-dense ion beams reaching solid-state density can be accelerated from thin target foils, exceeding the density of conventionally accelerated ion beams by about 14 orders of magnitude. This unique property of laser-accelerated ion beams can be exploited to explore the scenario of a new reaction mechanism called `fission-fusion', which will be introduced in the second part of the article. Accelerating fissile species (e.g. 232Th ) towards a second layer of the same material will lead to fission both of the beam-like and target-like particles. Due to the close to solid-state density of the accelerated ion bunches, fusion may occur between neutron-rich (light) fission products. This may open an access path towards extremely neutron-rich nuclides in the vicinity of the N=126 waiting point of the astrophysical r process. `Waiting points' at closed nucleon shells play a crucial role in controlling the reaction rates. However, since most of the pathway of heavy-element formation via the rapid-neutron capture process (r-process) runs in `terra incognita' of the nuclear landscape, in particular the waiting point at N=126 is yet unexplored and will remain largely inaccessible to conventional nuclear reaction

  14. ELIMED: a new hadron therapy concept based on laser driven ion beams

    NASA Astrophysics Data System (ADS)

    Cirrone, Giuseppe A. P.; Margarone, Daniele; Maggiore, Mario; Anzalone, Antonello; Borghesi, Marco; Jia, S. Bijan; Bulanov, Stepan S.; Bulanov, Sergei; Carpinelli, Massimo; Cavallaro, Salvatore; Cutroneo, Mariapompea; Cuttone, Giacomo; Favetta, Marco; Gammino, Santo; Klimo, Ondrej; Manti, Lorenzo; Korn, Georg; La Malfa, Giuseppe; Limpouch, Jiri; Musumarra, Agatino; Petrovic, Ivan; Prokupek, Jan; Psikal, Jan; Ristic-Fira, Aleksandra; Renis, Marcella; Romano, Francesco P.; Romano, Francesco; Schettino, Giuseppe; Schillaci, Francesco; Scuderi, Valentina; Stancampiano, Concetta; Tramontana, Antonella; Ter-Avetisyan, Sargis; Tomasello, Barbara; Torrisi, Lorenzo; Tudisco, Salvo; Velyhan, Andriy

    2013-05-01

    Laser accelerated proton beams have been proposed to be used in different research fields. A great interest has risen for the potential replacement of conventional accelerating machines with laser-based accelerators, and in particular for the development of new concepts of more compact and cheaper hadrontherapy centers. In this context the ELIMED (ELI MEDical applications) research project has been launched by INFN-LNS and ASCR-FZU researchers within the pan-European ELI-Beamlines facility framework. The ELIMED project aims to demonstrate the potential clinical applicability of optically accelerated proton beams and to realize a laser-accelerated ion transport beamline for multi-disciplinary user applications. In this framework the eye melanoma, as for instance the uveal melanoma normally treated with 62 MeV proton beams produced by standard accelerators, will be considered as a model system to demonstrate the potential clinical use of laser-driven protons in hadrontherapy, especially because of the limited constraints in terms of proton energy and irradiation geometry for this particular tumour treatment. Several challenges, starting from laser-target interaction and beam transport development up to dosimetry and radiobiology, need to be overcome in order to reach the ELIMED final goals. A crucial role will be played by the final design and realization of a transport beamline capable to provide ion beams with proper characteristics in terms of energy spectrum and angular distribution which will allow performing dosimetric tests and biological cell irradiation. A first prototype of the transport beamline has been already designed and other transport elements are under construction in order to perform a first experimental test with the TARANIS laser system by the end of 2013. A wide international collaboration among specialists of different disciplines like Physics, Biology, Chemistry, Medicine and medical doctors coming from Europe, Japan, and the US is growing up

  15. 38. METAL WORKING TOOLS AND MACHINES ADJACENT TO THE CIRCA ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. METAL WORKING TOOLS AND MACHINES ADJACENT TO THE CIRCA 1900 MICHIGAN MACHINERY MFG. CO. PUNCH PRESS NEAR THE CENTER OF THE FACTORY BUILDING. AT THE LEFT FOREGROUND IS A MOVABLE TIRE BENDER FOR SHAPING ELI WINDMILL WHEEL RIMS. AT THE CENTER IS A FLOOR-MOUNTED CIRCA 1900 SNAG GRINDER OF THE TYPE USED FOR SMOOTHING ROUGH CASTINGS. ON THE WHEELED WORK STATION IS A SUNNEN BUSHING GRINDER, BEHIND WHICH IS A TRIPOD CHAIN VICE. IN THE CENTER BACKGROUND IS A WOODEN CHEST OF DRAWERS WHICH CONTAINS A 'RAG DRAWER' STILL FILLED WITH CLOTH RAGS PLACED IN THE FACTORY BUILDING AT THE INSISTENCE OF LOUISE (MRS. ARTHUR) KREGEL FOR THE CONVENIENCE AND CLEANLINESS OF WORKERS. IN THE LEFT BACKGROUND IS A CIRCA 1900 CROSS-CUTOFF CIRCULAR SAW. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  16. The Occurrence of Type S1A Serine Proteases in Sponge and Jellyfish

    NASA Technical Reports Server (NTRS)

    Rojas, Ana; Doolittle, Russell F.

    2003-01-01

    Although serine proteases are found in all kinds of cellular organisms and many viruses, the classic "chymotrypsin family" (Group S1A by th e 1998 Barrett nomenclature) has an unusual phylogenetic distribution , being especially common in animals, entirely absent from plants and protists, and rare among fungi. The distribution in Bacteria is larg ely restricted to the genus Streptomyces, although a few isolated occ urrences in other bacteria have been reported. The family may be enti rely absent from Archaea. Although more than a thousand sequences have been reported for enzymes of this type from animals, none of them ha ve been from early diverging phyla like Porifera or Cnidaria, We now report the existence of Group SlA serine proteases in a sponge (phylu m Porifera) and a jellyfish (phylum Cnidaria), making it safe to conc lude that all animal groups possess these enzymes.

  17. Strategies for conducting ADME studies during lead generation in the drug discovery process.

    PubMed

    Cramer, Jeffrey W; Mattioni, Brian E; Savin, Kenneth A

    2010-12-01

    Although the benefit of early ADME screening is widely recognized in the pharmaceutical industry, the implementation of this paradigm is often performed with insufficient resources and poor collaboration between functions. Dedicated and consistent integration efforts of ADME knowledge during the lead generation (LG) phase of drug discovery enables informed resourcing decisions and also increases the quality of initial starting points for discovery projects. To facilitate the efficient and consistent application of ADME resources to early projects at Eli Lilly and Co, a team of scientists was formed to provide dedicated ADME support to the LG phase of the discovery portfolio. This feature review discusses the working construct of the team, the general philosophy that was employed, and the outcomes of this endeavor.

  18. Effect of cryogenic irradiation on NERVA structural alloys

    NASA Technical Reports Server (NTRS)

    Dixon, C. E.; Davidson, M. J.; Funk, C. W.

    1972-01-01

    Several alloys (Hastelloy X, AISI 347, A-286 bolts, Inconel 718, Al 7039-T63 and Ti-5Al-2.5Sn ELI) were irradiated in liquid nitrogen (140 R) to neutron fluences between 10 to the 17th power and 10 to the 19th power nvt (E greater than 1.0 Mev). After irradiation, tensile properties were obtained in liquid nitrogen without permitting any warmup except for some specimens which were annealed at 540 R. The usual trend of radiation damage typical for materials irradiated at and above room temperature was observed, such as an increase in strength and decrease in ductility. However, the damage at 140 R was greater because this temperature prevented the annealing of radiation-induced defects which occurs above 140 R.

  19. Historical estimates of external gamma exposure and collective external gamma exposure from testing at the Nevada Test Site. I. Test series through HARDTACK II, 1958

    SciTech Connect

    Anspaugh, L.R.; Church, B.W.

    1986-07-01

    In 1959, the Test Manager's Committee to Establish Fallout Doses calculated estimated external gamma exposure at populated locations based upon measurements of external gamma-exposure rate. Using these calculations and estimates of population, we have tabulated the collective estimated external gamma exposures for communities within established fallout patterns. The total collective estimated external gamma exposure is 85,000 person-R. The greatest collective exposures occurred in three general areas: Saint George, UT; Ely, NV; and Las Vegas, NV. Three events, HARRY (19 May 1953), BEE (22 March 1955), and SMOKY (31 August 1957), accounted for more than half the total collective estimated external gamma exposure. The bases of the calculational models for external gamma exposure of infinite exposure, estimated exposure, and 1-yr effective biological exposure are explained.

  20. A Global Map of Open Water Bodies and Coastlines at 150m Based on Synergies Between SAR and Optical Datasets

    NASA Astrophysics Data System (ADS)

    Lamarche, Celine; Santoro, Maurizio; Bontemps, Sophie; d'Andrimont, Raphael; Giustarini, Laura; Brockmann, Carsten; Militzer, Jan; Defourny, Pierre; Arino, Olivier

    2016-08-01

    In the framework of the European Space Agency Climate Change Initiative, a global map of open water bodies and coastlines at 150 m resolution was derived using synthetic aperture radar and optical datasets including observations from the 2000-2012 period. This map and constitutive inputs were assessed qualitatively and quantitatively against a global reference validation database of 2110 samples, intentionally biased towards areas prone to errors in characterizing water bodies. It yielded more informative quality assessment figures in terms of the relative improvement between products and types of errors. The overall accuracy of the Climate Change Initiative global map of open water bodies at 150 m was found equal to 99% with a F-score of 89% for class water, significantly superior to its constitutive input water bodies datasets. The dataset is openly available at: http://maps.elie.ucl.ac.be/CCI/viewer since 2016.

  1. Fracture characteristics, microstructure, and tissue reaction of Ti-5Al-2.5Fe for orthopedic surgery

    NASA Astrophysics Data System (ADS)

    Niinomi, Mitsuo; Kobayashi, Toshiro; Toriyama, Osamu; Kawakami, Noriaki; Ishida, Yoshihito; Matsuyama, Yukihiro

    1996-12-01

    The microstructure of Ti-5Al-2.5Fe, which is expected to be used widely as an implant material not only for artificial hip joints but also for instrumentations of scoliosis surgery, was variously changed by heat treatments. The effect of the microstructure on mechanical properties, fracture toughness, and rotating-bending fatigue strength in the air and simulated body environment, that is, Ringer’s solution, was then investigated. Furthermore, the effect of the living body environment on mechanical properties and fracture toughness in Ti-5Al-2.5Fe were investigated on the specimens implanted into rabbit for about 11 months. The data of Ti-5Al-2.5Fe were compared with those of Ti-6Al-4V ELI, which has been used as an implant material mainly for artificial hip joints, and SUS 316L, which has been used as an implant material for many parts, including the instrumentation of scoliosis surgery. The equiaxed α structure, which is formed by annealing at a temperature below β transus, gives the best balance of strength and ductility in Ti-5Al-2.5Fe. The coarse Widmanstätten α structure, which is formed by solutionizing over β transus followed by air cooling and aging, gives the greatest fracture toughness in Ti-5Al-2.5Fe. This trend is similar to that reported in Ti-6Al-4V ELI. The rotating-bending fatigue strength is the greatest in the equiaxed α structure, which is formed by solutionizing below β transus followed by air cooling and aging in Ti-5Al-2.5Fe. Ti-5Al-2.5Fe exhibits much greater rotating-bending fatigue strength compared with SUS 316L, and equivalent rotating-bending fatigue strength to that of Ti-6Al-4V ELI in both the air and simulated body environments. The rotating-bending fatigue strength of SUS 316L is degraded in the simulated body environment. The corrosion fatigue, therefore, occurs in SUS 316L in the simulated body environment. Fatigue strength of Ti-5Al-2.5Fe in the simulated body environment is degraded by lowering oxygen content in the

  2. Team 408 prepares for the FIRST competition

    NASA Technical Reports Server (NTRS)

    2000-01-01

    The Roboticks team (408) carries their robot, which is named R2K, during the FIRST competition. The team of students from Blanche Ely High School in Ft. Lauderdale was co-sponsored by Nortel Networks and NASA Kennedy Space Center. Students from all over the country are at the KSC Visitor Complex for the FIRST (For Inspiration and Recognition of Science and Technology) Southeast Regional competition March 9-11 in the Rocket Garden. Teams of high school students are testing the limits of their imagination using robots they have designed, with the support of business and engineering professionals and corporate sponsors, to compete in a technological battle against other schools' robots. Of the 30 high school teams competing, 16 are Florida teams co-sponsored by NASA and KSC contractors. Local high schools participating are Astronaut, Bayside, Cocoa Beach, Eau Gallie, Melbourne, Melbourne Central Catholic, Palm Bay, Rockledge, Satellite, and Titusville.

  3. Patent border wars: defining the boundary between scientific discoveries and patentable inventions.

    PubMed

    Holman, Christopher M

    2007-12-01

    Drawing an appropriate boundary between unpatentable natural phenomena and patentable inventions is crucial in preventing the patent laws from unduly restricting access to fundamental scientific discoveries. Some would argue that, particularly in the U.S., patents are being issued that purport to claim a novel product or process but that, in effect, encompass any practical application of a fundamental biological principle. Examples include gene patents, which Congress is considering banning, and patents relating to biological correlations and pathways, such as the patents at issue in the headline-grabbing LabCorp v. Metabolite and Ariad v. Eli Lilly litigations. In view of the mounting concern, it seems likely that Congress and/or the courts will address the issue, and perhaps substantially shift the boundary.

  4. Historical estimates of external gamma exposure and collective external gamma exposure from testing at the Nevada Test Site. I. Test series through HARDTACK II, 1958

    SciTech Connect

    Anspaugh, L.R.; Church, B.W.

    1985-12-01

    In 1959, the Test Manager's Committee to Establish Fallout Doses calculated estimated external gamma exposure at populated locations based upon measurements of external gamma-exposure rate. Using these calculations and estimates of population, we have tabulated the collective estimated external gamma exposures for communities within established fallout patterns. The total collective estimated external gamma exposure is 85,000 person-R. The greatest collective exposures occurred in three general areas: Saint George, Utah; Ely, Nevada; and Las Vegas, Nevada. Three events, HARRY (May 19, 1953), BEE (March 22, 1955), and SMOKY (August 31, 1957), accounted for over half of the total collective estimated external gamma exposure. The bases of the calculational models for external gamma exposure of ''infinite exposure,'' ''estimated exposure,'' and ''one year effective biological exposure'' are explained. 4 figs., 7 tabs.

  5. Investigation of flaw geometry and loading effects on plane strain fracture in metallic structures

    NASA Technical Reports Server (NTRS)

    Hall, L. R.; Finger, R. W.

    1971-01-01

    The effects on fracture and flaw growth of weld-induced residual stresses, combined bending and tension stresses, and stress fields adjacent to circular holes in 2219-T87 aluminum and 5AI-2.5Sn(ELI) titanium alloys were evaluated. Static fracture tests were conducted in liquid nitrogen; fatigue tests were performed in room air, liquid nitrogen, and liquid hydrogen. Evaluation of results was based on linear elastic fracture mechanics concepts and was directed to improving existing methods of estimating minimum fracture strength and fatigue lives for pressurized structure in spacecraft and booster systems. Effects of specimen design in plane-strain fracture toughness testing were investigated. Four different specimen types were tested in room air, liquid nitrogen and liquid hydrogen environments using the aluminum and titanium alloys. Interferometry and holograph were used to measure crack-opening displacements in surface-flawed plexiglass test specimens. Comparisons were made between stress intensities calculated using displacement measurements, and approximate analytical solutions.

  6. Nucleosome functions in spindle assembly and nuclear envelope formation

    PubMed Central

    Zierhut, Christian; Funabiki, Hironori

    2016-01-01

    Summary Chromosomes are not only carriers of the genetic material, but also actively regulate the assembly of complex intracellular architectures. During mitosis, chromosome-induced microtubule polymerisation ensures spindle assembly in cells without centrosomes and plays a supportive role in centrosome-containing cells. Chromosomal signals also mediate post-mitotic nuclear envelope (NE) re-formation. Recent studies using novel approaches to manipulate histones in oocytes, where functions can be analysed in the absence of transcription, have established that nucleosomes, but not DNA alone, mediate the chromosomal regulation of spindle assembly and NE formation. Both processes require the generation of RanGTP by RCC1 recruited to nucleosomes but nucleosomes also acquire cell cycle stage specific regulators, Aurora B in mitosis and ELYS, the initiator of nuclear pore complex assembly, at mitotic exit. Here, we review the mechanisms by which nucleosomes control assembly and functions of the spindle and the NE, and discuss their implications for genome maintenance. PMID:26222742

  7. Upstream solutions for price-gouging on critical generic medicines.

    PubMed

    Houston, Adam R; Beall, Reed F; Attaran, Amir

    2016-01-01

    Exorbitant price increases for critical off-patent medicines have received considerable media attention in recent months, leading to an investigation by the U.S. Senate. However, much of this attention has focused upon the companies that initiated the price increases, all of whom had recently acquired the drugs in question. Overlooked are upstream interventions with the originators of these drugs to prevent generics trolling in the first place. Using the particular example of Eli Lilly and Company's efforts to divest itself of cycloserine, a flawed process that paved the way for the recent price hike by Rodelis Therapeutics, this article highlights the responsibilities of drug originators, and safeguards to ensure similar rights transfers do not affect ongoing affordable access.

  8. Two companies turn bright ideas into winning technologies

    SciTech Connect

    Bishop, J.

    1997-01-01

    Every environmentalist and environmental manager dreams of a day when it will be possible to load hazardous waste into one end of a magic machine and retrieve beneficial -- or at least benign -- products from the other end. Two unrelated companies -- Molten Metal Technology Inc., (Waltham, Mass.) and ELI Eco Logic Inc. (Rockwood, Ontario, Canada) -- have developed different technologies that show promise of realizing such dreams. Whether either company`s solution to the problem of effectively managing hazardous wastes proves to be the dream machine remains to be seen, but their stories offer insight into what the future may hold for hazardous waste management. The Eco Logic Process was demonstrated in 1991 at Hamilton Harbour, Ontario, and later at Bay City, Mich., in cleanups of polychlorinated biphenyls (PCBs) and other soil contaminants. The technology was accepted into the US Environmental Protection Agency`s Superfund Innovative Technology Evaluation (SITE) program in 1992.

  9. Novel applications and future perspectives of a fast diamond gamma ray detector

    NASA Astrophysics Data System (ADS)

    Williams, T.; Martens, A.; Cassou, K.; Zomer, F.; Griesmayer, E.; Kavrigin, P.

    2017-02-01

    For the first time, a diamond sensor was operated for the characterisation of a high average-intensity gamma-ray beam. Data was collected for gamma beam energies between 2 and 7 MeV, at the HIγS facility of TUNL. The nanosecond-fast resolution of diamond detectors is exploited to distinguish bunches of gamma rays 16.8 ns apart. It allows a precise direct determination of the time-structure of the gamma beam. The strong potential of such a detector for precise absolute flux, position and polarisation measurements is exposed. It is thus shown that diamond detectors are a decisive and unique tool for the detailed characterisation of upcoming gamma sources, such as ELI-NP and HIγS-2.

  10. Pair plasma formation in the interaction of a thin plasma with ultra-intense counter-propagating lasers

    NASA Astrophysics Data System (ADS)

    Slade-Lowther, Cody

    2016-10-01

    Next-generation lasers (e.g. ELI) expect to reach peak intensities of 1023 Wcm-2. At such intensities, the electromagnetic field strength is sufficient for non-linear Quantum Electrodynamics effects to become important. The processes of non-linear Compton scattering and Breit-Wheeler Pair production become likely at intensities >=1023 Wcm-2, and have been predicted to lead to prolific pair and γ-ray production via electromagnetic cascades. We present results for the case of two counter-propagating circularly- polarized lasers of intensity I ∈ [1023 ,1025 ] Wcm24 interacting with a plasma of initial density n0 ∈ [1025 ,1035 ] via the Monte-Carlo- particle-in-cell code EPOCH. We show the maximum pair plasma density in I vs n0 space. We further discuss the variation within this space on the plasma characteristics, including laser absorption and field-particle energy distribution.

  11. Seeded QED cascades in counterpropagating laser pulses

    NASA Astrophysics Data System (ADS)

    Grismayer, T.; Vranic, M.; Martins, J. L.; Fonseca, R. A.; Silva, L. O.

    2017-02-01

    The growth rates of seeded QED cascades in counterpropagating lasers are calculated with first-principles two- and three-dimensional QED-PIC (particle-in-cell) simulations. The dependence of the growth rate on the laser polarization and intensity is compared with analytical models that support the findings of the simulations. The models provide insight regarding the qualitative trend of the cascade growth when the intensity of the laser field is varied. A discussion about the cascade's threshold is included, based on the analytical and numerical results. These results show that relativistic pair plasmas and efficient conversion from laser photons to γ rays can be observed with the typical intensities planned to operate on future ultraintense laser facilities such as ELI or Vulcan.

  12. Optimization of positrons generation based on laser wakefield electron acceleration

    NASA Astrophysics Data System (ADS)

    Wu, Yuchi; Han, Dan; Zhang, Tiankui; Dong, Kegong; Zhu, Bin; Yan, Yonghong; Gu, Yuqiu

    2016-08-01

    Laser based positron represents a new particle source with short pulse duration and high charge density. Positron production based on laser wakefield electron acceleration (LWFA) has been investigated theoretically in this paper. Analytical expressions for positron spectra and yield have been obtained through a combination of LWFA and cascade shower theories. The maximum positron yield and corresponding converter thickness have been optimized as a function of driven laser power. Under the optimal condition, high energy (>100 MeV ) positron yield up to 5 ×1011 can be produced by high power femtosecond lasers at ELI-NP. The percentage of positrons shows that a quasineutral electron-positron jet can be generated by setting the converter thickness greater than 5 radiation lengths.

  13. Optimized multibeam configuration for observation of QED cascades

    NASA Astrophysics Data System (ADS)

    Gelfer, E. G.; Mironov, A. A.; Fedotov, A. M.; Bashmakov, V. F.; Nerush, E. N.; Kostyukov, I. Yu.; Narozhny, N. B.

    2015-08-01

    QED cascades in an intense electromagnetic field can occur if the dynamical quantum parameter χ of a seed electron, which in Compton units coincides with the electron proper acceleration, attains the order of unity. We derive a general expression for χ of an initially slow electron in an arbitrary electromagnetic field for a time range t ≪1 /ω , where ω is the field carrier frequency. Using this formula, we consider a special field configuration of multiple colliding focused laser beams and optimize it to provide cascade development at laser power below 10 PW and intensity of the order of 1023W /cm2 . Such parameters of the beams will be obtained with a new generation of laser facilities, particularly the ELI Beamlines, in the coming years.

  14. Resonant scattering of ultrarelativistic electrons in the strong field of a pulsed laser wave

    NASA Astrophysics Data System (ADS)

    Lebed', A. A.; Padusenko, E. A.; Roshchupkin, S. P.

    2016-02-01

    Electron-electron scattering in a strong field of a pulsed laser wave is studied theoretically. Resonant scattering kinematics at the small polar angles for electron ultrarelativistic energy is studied in detail. Compact analytical expressions for the amplitude and the differential cross section for wave elliptical polarization are obtained under resonant conditions. The resonant cross section of electron-electron scattering is shown to decrease sharply with increasing the electron ultrarelativistic energies for weak and moderately strong fields. It was demonstrated that the resonant cross section of electron-electron scattering at wave circular polarization is four times greater than the corresponding cross section at linear polarization. The resonant cross section may exceed the corresponding cross section of a field-free process: by 5-6 orders of magnitude for electron MeV-energy and petawatt optical lasers (PHELIX, Vulcan); and 8-9 orders for multipetawatt laser fields within the femtosecond range (Vulcan10, ELI).

  15. Nuclear Astrophysics at IFIN-HH

    NASA Astrophysics Data System (ADS)

    Livius, Trache

    2016-04-01

    I will present the possibilities and some results of doing nuclear astrophysics research in IFIN-HH Bucharest-Magurele. There are basically two lines of experimental activities: (1) direct measurements with beams from the local accelerators, in particular with the new 3 MV Tandetron accelerator. This facility turns out to be competitive for reactions induced by a-particles and light ions. Extra capabilities are given by the ultra-low background laboratory we have in a salt mine about 2.5 hrs. driving north of Bucharest; (2) indirect measurements done with beams at international facilities, in particular at those providing Rare Ion Beams. Completely new and unique opportunities will be provided by ELI-NP, under construction in our institute.

  16. Resonance of the exchange amplitude of a photon by an electron scattering in a pulsed laser field

    NASA Astrophysics Data System (ADS)

    Nedoreshta, V. N.; Roshchupkin, S. P.; Voroshilo, A. I.

    2015-06-01

    Resonant scattering of a photon by an electron in the presence of the field of the low intensity circularly polarized pulsed laser wave is studied theoretically. The approximation used the case in which a laser-pulse duration is significantly greater than the characteristic oscillation time. The resonance conditions of the exchange diagrams by electron and positron intermediate states were determined. The probability of such a process is calculated. It is demonstrated that the resonant probability may be six to ten orders of magnitude higher than the probability of the Compton effect in the absence of the external field. Obtained results can be verified experimentally in the framework of modern research projects (SLAC, FAIR, XFEL, and ELI).

  17. Explosion of relativistic electron vortices in laser plasmas

    NASA Astrophysics Data System (ADS)

    Lezhnin, Kirill; Kamenets, Fedor; Esirkepov, Timur; Bulanov, Sergei; Gu, Yanjun; Weber, Stefan; Korn, Georg

    2016-10-01

    The interaction of high intensity laser radiation with underdense plasma may lead to the formation of electron vortices. Though being quasistationary on an electron timescales, these structures tend to expand on a proton timescale due to Coloumb repulsion of ions. Using a simple analytical model of a stationary vortex as initial condition, 2D PIC simulations are performed. A number of effects are observed such as vortex boundary field intensification, multistream instabilities at the vortex boundary, and bending of the vortex boundary with the subsequent transformation into smaller electron vortices. This work was supported by the ELI Project No. CZ.02.1.01/0.0/0.0/15 008/0000162. We also would like to acknowledge the support from Russian Foundation for Basic Research (Grant No. 15-02-03063).

  18. Seeded QED cascades in counterpropagating laser pulses.

    PubMed

    Grismayer, T; Vranic, M; Martins, J L; Fonseca, R A; Silva, L O

    2017-02-01

    The growth rates of seeded QED cascades in counterpropagating lasers are calculated with first-principles two- and three-dimensional QED-PIC (particle-in-cell) simulations. The dependence of the growth rate on the laser polarization and intensity is compared with analytical models that support the findings of the simulations. The models provide insight regarding the qualitative trend of the cascade growth when the intensity of the laser field is varied. A discussion about the cascade's threshold is included, based on the analytical and numerical results. These results show that relativistic pair plasmas and efficient conversion from laser photons to γ rays can be observed with the typical intensities planned to operate on future ultraintense laser facilities such as ELI or Vulcan.

  19. Parametric interference effect in electron-nucleus scattering in the field of two pulsed laser waves

    NASA Astrophysics Data System (ADS)

    Roshchupkin, S. P.; Lebed', A. A.

    2014-09-01

    Electron scattering on a nucleus in a field of two unidirectional pulsed laser waves is considered. The parametric interference effect is studied, which manifests in electron scattering within the plane formed by both the direction of laser-wave propagation and the initial electron momentum (the interference region). In this kinematics the electron emits and absorbs photons of both waves in a correlated manner. The distribution of the differential cross section of the final-electron energy for the process of electron-nucleus scattering in the field of two pulsed waves is considered. This distribution in the interference region differs qualitatively and quantitatively from the corresponding distribution in any other geometry. The appearance of the parametric interference effect may be experimentally verified by measuring the energy spectrum of final electrons in the framework of modern research projects, which use sources of pulsed laser radiation (XFEL, ELI, PHELIX).

  20. Northeast Minneapolis: Location and Movement in an Ethnic Community.

    DTIC Science & Technology

    1979-06-01

    with Polish s , 6, +, t, and ~;the Slovak * r , ~ 27 and z; or the Ukrainian name written in the Cyrillic alphabet? The second step (roughly seventy years...10 0 -i LA ’I a) ON C OLA 00a r - U) LL ON .*4 qw q.0 CD i m, rqw LA.r-l LA) Z 4-4 󈧰N C; C; 2a 4m C4rn( S ) mL) I- f ) LnC DE4 U) m - CV M -W U) I...15 59 am Eli man a an a~ ma r ana 13 a SIX I6 M ?ILE NORTHEAST MINNEAPOLIS-1915 PERCENTAGE OF POPULATION: YANKEES FIGURE 3-16 60 Us a 13 a om*8 0 m s

  1. The Lichnerowicz-Weitzenboeck formula and superconductivity

    SciTech Connect

    Vargas-Paredes, Alfredo A.; Doria, Mauro M.; Neto, Jose Abdala Helayeel

    2013-01-15

    We derive the Lichnerowicz-Weitzenboeck formula for the two-component order parameter superconductor, which provides a twofold view of the kinetic energy of the superconductor. For the one component order parameter superconductor we review the connection between the Lichnerowicz-Weitzenboeck formula and the Ginzburg-Landau theory. For the two-component case we claim that this formula opens a venue to describe inhomogeneous superconducting states intertwined by spin correlations and charged dislocation. In this case the Lichnerowicz-Weitzenboeck formula displays local rotational and electromagnetic gauge symmetry (SU(2) Circled-Times U(1)) and relies on local commuting momentum and spin operators. The order parameter lives in a space with curvature and torsion described by Elie Cartan geometrical formalism. The Lichnerowickz-Weitzenboeck formula leads to first order differential equations that are a three-dimensional version of the Seiberg-Witten equations.

  2. Function-Theoretic Techniques for the Electromagnetic Scattering by a Resistive Wedge.

    DTIC Science & Technology

    1981-09-01

    written in the form [ ’ 1 [ A(V) ] B(.) 121 eli(w/2)v (4.20 j [C(V) cosv + DM sin + v sin v -[d ( -65-I * gwhere the arbitrary functions A,B,C, and D are...cos v(-r- " -)] (4.40a) ces[(1 + VX7 -¢) Foi(l + ) Cos[(’ - ) Foil v) ’I sin( l+v Or 0i~ ~v7r0 Fo(v) 4i~ [sln( *~) Cosv ~ -s~n + COS v4, 0i ~ + sin(O0...ikn ei (Tr/2)vf e e] H() sin vi Te(v 2 f €= (pd 0 = 21 csc v7r[nl(d - d ) + sin v(r - + p) - sinv( - o-1 2 0 (4.46a) II COSV (i " ’(v) _ "kn ei(w/2)v

  3. Separability of boreal forest species in the Lake Jennette area, Minnesota

    NASA Technical Reports Server (NTRS)

    Shen, S. S.; Carnes, J. G.; Badhwar, G. D.

    1985-01-01

    In order to exploit the use of thematic mapper (TM) data to obtain vegetation and net primary productivity maps in the boreal forest, three aircraft flights were undertaken over the area near Ely, MN, with the NS 001 Thematic Mapper Simulator. Attention is presently given to an analysis of these 1983 data, which attempted to separate coniferous trees from deciduous ones. Canopy reflectance models and measured optical properties of the scattering elements have been used to deepen understanding of this separability, and to relate the ratio of nadir view reflectances in TM bands 4 and 3 to the overstory leaf area index. A map that is proportional to the leaf area index for deciduous species is presented.

  4. Neutrophils: Cinderella of innate immune system.

    PubMed

    Kumar, V; Sharma, A

    2010-11-01

    Neutrophils are the first line of innate immune defense against infectious diseases. However, since their discovery by Elie Metchnikoff, they have always been considered tissue-destructive cells responsible for inflammatory tissue damage occurring during acute infections. Now, extensive research in the field of neutrophil cell biology and their role skewing the immune response in various infections or inflammatory disorders revealed their importance in the regulation of immune response. Along with releasing various antimicrobial molecules, neutrophils also release neutrophil extracellular traps (NETs) for the containment of infection and inflammation. Activated neutrophils provide signals for the activation and maturation of macrophages as well as dendritic cells. Neutrophils are also involved in the regulation of T-cell immune response against various pathogens and tumor antigens. Thus, the present review is intended to highlight the emerging role of neutrophils in the regulation of both innate and adaptive immunity during acute infectious or inflammatory conditions.

  5. Influence of gaseous hydrogen on metals

    NASA Technical Reports Server (NTRS)

    Walter, R. J.; Chandler, W. T.

    1973-01-01

    Tensile, fracture toughness, threshold stress intensity for sustained-load crack growth, and cyclic and sustained load crack growth rate measurements were performed on a number of alloys in high-pressure hydrogen and helium environments. The results of tensile tests performed in 34.5 MN/m2 (5000 psi) hydrogen indicated that Inconel 625 was considerable embrittled at ambient temperature but was not embrittled at 144 K (-200 F). The tensile properties of AISI 321 stainless steel were slightly reduced at ambient temperature and 144 K (-200 F). The tensile properties of Ti-5Al-2.5 Sn ELI were essentially unaffected by hydrogen at 144 K (-200 F). OFHC copper was not embrittled by hydrogen at ambient temperature or at 144 K (-200 F).

  6. Explosive Forming of Butt Welded Pipe Reducers.

    DTIC Science & Technology

    1979-04-01

    Ao—A 072 I3Q NAVAL ORDNANCE STATION LOUISVILLE KY F~ G 13/it EXPLOSIVE FORMING OF BIJTT WELDED PIPE REDUCERS. (U) APR 79 M W JO$*4SON UNCLASSIFIED...NOSL MT OS2 _ Eli _ _El [LII] DliB I I —~~~~~~~~~~ I 4 1 V S -. RB’ORT NO. M1052 AP~t 1919v-fl o~toswE FORMING (j~~c BUTI WELDED PIPE RE~~~ A PQWECT...MING BUTT WELDED PIPE REDUCERS A PROJECT OP THE MANUFACTURING TECHNOLOGY PROGR AM NAVAL SEA SYST~~(S COMMA ND fiNAL REPORT NAVAL ORDNANCE STATION L

  7. The effect of polyethylene glycol adhesion barrier (Spray Gel) on preventing peritoneal adhesions.

    PubMed

    Dasiran, F; Eryilmaz, R; Isik, A; Okan, I; Somay, A; Sahin, M

    2015-01-01

    The prominent cells in the late phase of wound healing during proliferation and matrix deposition are fibroblasts. Foreign materials in the operation site like prosthesis prolong the inflammation and induce fibroblast proliferation (8). 3 different prostheses used in this study induced chronic inflammation and fibrosis and provided an effective repair. Dense and thick adhesions due to fibrosis also induced strong adhesions to omentum and small intestine if only polypropylene mesh used for hernia repair. However, there was no difference between SprayGel treated polypropylene mesh and Sepramesh when compared for fibrosis. It also prevents the intraabdominal adhesion formation. It is nontoxic, sticky adherent, non- immigrant and easy to use both in open and laparoscopic surgeries. This experimental study revealed that polyethyleneglycol applied polypropylene mesh accomplishes hernia repair with significantly less adhesion formation than polypropylene mesh alone while securing a remarkable economy than adhesion barrier coated dual meshes (Tab. 6, Fig. 7, Ref. 23). Text in PDF www.elis.sk.

  8. National Program for Inspection of Non-Federal Dams. Clam Lake Dam (MA 01052), Connecticut River Basin, Sandisfield, Massachusetts. Phase I Inspection Report.

    DTIC Science & Technology

    1980-02-01

    special elbow, subsequent to earlier checks (which found no cracking in that section). It is recommended that a grid system be marked off on the...COMMISSION -ION DISTRICT 0 A’SSACH USETTS :nce of t.I( \\SERVICE -_NT of AGRICULTURE2 3W.* 4-E 44- EMERGENCY SPILLWAY DRAIN tET 15- EMERGENCY SPILLWAY...ot 11 tet so 7/14/63 10. 35.0 3.$ 40 34 u0 202s 4 lev t 3 f ..t O /24/45, ot. level 0.0D11_ ELI. 1214. 6118-24/65 DIK. D0 0 TO1i O0j 40 0.5 l*ot o 7/04

  9. The 14th International Conference on Alzheimer's Drug Discovery, 9 - 10 September 2013, in Jersey City, New Jersey.

    PubMed

    Glicksman, Marcie A

    2014-02-01

    The following conference was the 14th International Conference on Alzheimer's Drug Discovery held 9 - 10 September 2013, in Jersey City, NJ. The conference attracted about 140 attendees with 49% from academia, 36% from industry and private practice, 10% from nonprofit organizations and 2% from the government. The meeting had two plenary speakers that kicked off each morning of the conference and then two sessions each day to cover different aspects of Alzheimer's disease drug discovery. There were sessions on neuroprotection, mitochondrial function, biomarkers, ApoE, tau and protein clearance. The conference was organized by the Alzheimer's Drug Discovery Foundation (ADDF) with all of the presenters supported by grants awarded by the ADDF. The conference had financial support from the pharmaceutical companies Merck & Co., Eli Lilly & Co. and Pfizer, Inc. Friends, exhibitors and media partners also helped financially support the conference.

  10. Complete genome sequence of Marinomonas posidonica type strain (IVIA-Po-181T)

    SciTech Connect

    Lucas-Elio, Patricia; Goodwin, Lynne A.; Woyke, Tanja; Pitluck, Sam; Nolan, Matt; Kyrpides, Nikos C; Detter, J C; Copeland, A; Lu, Megan; Bruce, David; Detter, J. Chris; Tapia, Roxanne; Han, Cliff; Land, Miriam L; Ivanova, N; Mikhailova, Natalia; Johnston, Andrew W. B.; Sanchez-Amat, Antonio

    2012-01-01

    Marinomonas posidonica IVIA-Po-181T Lucas-Eli o et al. 2011 belongs to the family Oceanospirillaceae within the phylum Proteobacteria. Different species of the genus Marinomonas can be readily isolated from the seagrass Posidonia oceanica. M. posidonica is among the most abundant species of the genus detected in the cultured microbiota of P. oceanica, suggesting a close relationship with this plant, which has a great ecological value in the Mediterranean Sea, covering an estimated surface of 38,000 Km2. Here we describe the genomic features of M. posidonica. The 3,899,940 bp long genome harbors 3,544 pro- tein-coding genes and 107 RNA genes and is a part of the Genomic Encyclopedia of Bacteria and Archaea project.

  11. Small satellites with micro-propulsion for communications with the Lunar South Pole Aitkens Basin

    NASA Astrophysics Data System (ADS)

    Haque, Samudra E.; Straub, Jeremy; Whalen, David

    A lunar sample return mission to the Lunar South-Pole Aitkens Basin (LSPAB) has been highlighted as a high priority objective of the most recent (2011) Decadal Survey for Planetary Science, by the National Research Council. This class of mission, however, faces a dramatic communications limitation, due to the lack of a frequent, or continuous, line-of-sight communications path to Earth-based ground stations. Brunner and others have proposed a communications system utilizing Low Lunar Polar Orbits (LLPO) and Lunar Halo orbits for this purpose. Ely and others have outlined proposals for using several communication satellites to form a relay network using LLPO, taking into account the Lunar masscon's that would perturb such orbits. However, any relay network of communication satellites would still have to connect back to a suitable Earth-based ground station (Near Earth Network, or otherwise), or a tracking and data relaying satellite (e.g., TDRS).

  12. Proton/Electron Damage Ratios for Some Violet, Black and Thin Silicon Solar Cells.

    DTIC Science & Technology

    1979-11-01

    2 to 10 MeV) Type Proton fluence cm 2 A 0, 1E9, 1E10, 3E10 , 1Eli, 1E12 B 0, 1E10, 3E10 , 1.1E11, 3.1E11, 1.11E12 C 0, 1E9, IEIO, 3E10 , 1EVI, IE12 D 0...1E10, 3E10 , 1.1E11, 3.1E11, 1.11E12 Table 5 PROTON FLUENCES (19 and 50 MeV) Type Proton fluence cm 2 A 0, 2E10, 1E11, 1.1E12 B 0, 1Ell, 5E11, 1.5E12

  13. Pile-up recovery in gamma-ray detection

    SciTech Connect

    Vencelj, Matjaz; Likar, Andrej; Loeher, Bastian; Miklavec, Mojca; Novak, Roman; Pietralla, Norbert; Savran, Deniz

    2012-07-09

    Count rates in gamma-ray detectors are fundamentally limited at the high end by the physics of the detection process but should not be limited further by the design of read-out. Using intense stimuli, such as the ELI, it is desirable to extract the full wealth of information flow that sensors can deliver. We discuss the photon-statistical limitations of scintillation systems and charge-collection issues of solid-state detectors. With high-speed digitizing in particular, two promising approach architectures are those of posterior list mode corrections and of time-domain adaptive filters, introducing a 'rich list mode with uncertainties' and thus a somewhat different look at experimental spectra. Real-time performance is also considered.

  14. Essays from the Edinburgh and Quarterly Reviews

    NASA Astrophysics Data System (ADS)

    Herschel, John

    2014-07-01

    1. Address to the subscribers to the Windsor and Eton Public Library; 2. Mechanism of the heavens; 3. Terrestrial magnetism; 4. Inductive sciences; 5. Kosmos; 6. Probabilities; 7. Address to the Royal Astronomical Society, 1827; 8. Address to the Royal Astronomical Society, 1828; 9. Address to the Royal Astronomical Society, 1829; 10. Address to the Royal Astronomical Society, 1840; 11. Address to the Royal Astronomical Society, 1841; 12. Memoir of the late F. Baily; 13. Address to the Royal Astronomical Society, 1849; 14. Address to the British Association for the Advancement of Science; 15. The walk; 16. Funeral dirge of a Nadowessie; 17. Dithyrambics; 18. Saying of Confucius - time; 19. Saying of Confucius - space; 20. Leonora; 21. Prose and verses; 22. To the lark; 23. Man the interpreter of nature; 24. A scene in Ely cathedral; 25. Mira; 26. The parting dove; 27. On burning a parcel of old MSS; 28. A dream which was not all a dream; 29. Appendix.

  15. Analysis of merits of hybrid wind/photovoltaic concept for stand-alone systems

    NASA Astrophysics Data System (ADS)

    Castle, J. A.; Kallis, J. M.; Moite, S. M.; Marshall, N. A.

    Methods for evaluating the merits of hybrid wind/photovoltaic systems for use in stand-alone applications were developed. The optimum mix of wind and photovoltaic power with an electrochemical storage system, with or without fossil fuel generator backup, depends upon the individual subsystem economics. A computer code was developed to calculate the optimum subsystem sizes that minimize the levelized energy cost. The actual merits of a hybrid system over a pure photovoltaic or wind system depend upon many factors: load profile; wind regime; insolation; cost and availability of backup power; the relative costs of wind rotor area, array area, and storage; and subsystem efficiency factors. Examples of optimized hybrid systems for a range of photovoltaic costs and estimated wind and storage costs are shown for an Ely, NV, application, where backup power is allowed to supply 5% of the total annual load.

  16. Dissipative particle dynamics model for colloid transport in porous media

    SciTech Connect

    Pan, W.; Tartakovsky, A. M.

    2013-08-01

    We present that the transport of colloidal particles in porous media can be effectively modeled with a new formulation of dissipative particle dynamics, which augments standard DPD with non-central dissipative shear forces between particles while preserving angular momentum. Our previous studies have demonstrated that the new formulation is able to capture accurately the drag forces as well as the drag torques on colloidal particles that result from the hydrodynamic retardation effect. In the present work, we use the new formulation to study the contact efficiency in colloid filtration in saturated porous media. Note that the present model include all transport mechanisms simultaneously, including gravitational sedimentation, interception and Brownian diffusion. Our results of contact efficiency show a good agreement with the predictions of the correlation equation proposed by Tufenkji and EliMelech, which also incorporate all transport mechanisms simultaneously without the additivity assumption.

  17. Research on recognition of the geologic framework of porphyry copper deposits on ERTS-1 imagery. [New Guinea, Alaska, and Colorado

    NASA Technical Reports Server (NTRS)

    Wilson, J. C. (Principal Investigator)

    1975-01-01

    The author has identified the following significant results. Many new linear and circular features were found. These features prompted novel tectonic classification and analysis especially in the Ray and Ely areas. Tectonic analyses of the Ok Tedi, Tanacross, and Silvertone areas follow conventional interpretations. Circular features are mapped in many cases and are interpreted as exposed or covered intrusive centers. The small circular features reported in the Ok Tedi test area are valid and useful correlations with tertiary intrusion and volcanism in this remote part of New Guinea. Several major faults of regional dimensions, such as the Denali fault in Alaska and the Colorado mineral belt structures in Colorado are detected in the imagery. Many more faults and regional structures are found in the imagery than exist on present maps.

  18. Identification by genomic immunization of a pool of DNA vaccine candidates that confer protective immunity in mice against Neisseria meningitidis serogroup B.

    PubMed

    Yero, Daniel; Pajón, Rolando; Pérez, Yusleydis; Fariñas, Mildrey; Cobas, Karem; Diaz, Daiyana; Solis, Rosa L; Acosta, Armando; Brookes, Charlotte; Taylor, Stephen; Gorringe, Andrew

    2007-07-09

    We have shown previously that expression library immunization is viable alternative approach to induce protective immunity against Neisseria meningitidis serogroup B. In this study we report that few rounds of library screening allow identification of protective pools of defined antigens. A previously reported protective meningococcal library (L8, with 600 clones) was screened and two sub-libraries of 95 clones each were selected based on the induction of bactericidal and protective antibodies in BALB/c mice. After sequence analysis of each clone within these sub-libraries, we identified a pool of 20 individual antigens that induced protective immune responses in mice against N. meningitidis infection, and the observed protection was associated with the induction of bactericidal antibodies. Our studies demonstrate for the first time that ELI combined with sequence analysis is a powerful and efficient tool for identification of candidate antigens for use in a meningococcal vaccine.

  19. Patents, antibiotics, and autarky in Spain.

    PubMed

    Romero De Pablos, Ana

    2014-01-01

    Patents on antibiotics were introduced in Spain in 1949. Preliminary research reveals diversification in the types of antibiotics: patents relating to penicillin were followed by those relating to streptomycin, erythromycin and tetracycline. There was also diversification in the firms that applied for patents: while Merck & Co. Incorporated and Schenley Industries Inc. were the main partners with Spanish antibiotics manufacturers in the late 1940s, this industrial space also included many others, such as Eli Lilly & Company, Abbott Laboratories, Chas. Pfizer & Co. Incorporated, and American Cyanamid Company in the mid-1970s. The introduction of these drugs in Spain adds new elements to a re-evaluation of the autarkic politics of the early years of the Franco dictatorship.

  20. Biophysical, morphological, canopy optical property, and productivity data from the Superior National Forest

    NASA Technical Reports Server (NTRS)

    Hall, F. G.; Huemmrich, K. F.; Strebel, D. E.; Goetz, S. J.; Nickeson, J. E.; Woods, K. D.

    1992-01-01

    Described here are the results of a NASA field experiment conducted in the Superior National Forest near Ely, Minnesota, during the summers of 1983 and 1984. The purpose of the experiment was to examine the use of remote sensing to provide measurements of biophysical parameters in the boreal forests. Leaf area index, biomass, net primary productivity, canopy coverage, overstory and understory species composition data are reported for about 60 sites, representing a range of stand density and age for aspen and spruce. Leaf, needle, and bark high-resolution spectral reflectance and transmittance data are reported for the major boreal forest species. Canopy bidirectional reflectance measurements are provided from a helicopter-mounted Barnes Multiband Modular Radiometer (MMR) and the Thematic Mapper Simulator (TMS) on the NASA C-130 aircraft.

  1. Validation Analysis of the Groundwater Flow and Transport Model of the Central Nevada Test Area

    SciTech Connect

    A. Hassan; J. Chapman; H. Bekhit; B. Lyles; K. Pohlmann

    2006-09-30

    The Central Nevada Test Area (CNTA) is a U.S. Department of Energy (DOE) site undergoing environmental restoration. The CNTA is located about 95 km northeast of Tonopah, Nevada, and 175 km southwest of Ely, Nevada (Figure 1.1). It was the site of the Faultless underground nuclear test conducted by the U.S. Atomic Energy Commission (DOE's predecessor agency) in January 1968. The purposes of this test were to gauge the seismic effects of a relatively large, high-yield detonation completed in Hot Creek Valley (outside the Nevada Test Site [NTS]) and to determine the suitability of the site for future large detonations. The yield of the Faultless underground nuclear test was between 200 kilotons and 1 megaton (DOE, 2000). A three-dimensional flow and transport model was created for the CNTA site (Pohlmann et al., 1999) and determined acceptable by DOE and the Nevada Division of Environmental Protection (NDEP) for predicting contaminant boundaries for the site.

  2. Humalog(®) KwikPen™: an insulin-injecting pen designed for ease of use.

    PubMed

    Schwartz, Sherwyn L; Ignaut, Debra A; Bodie, Jennifer N

    2010-11-01

    Insulin pens offer significant benefits over vial and syringe injections for patients with diabetes who require insulin therapy. Insulin pens are more discreet, easier for patients to hold and inject, and provide better dosing accuracy than vial and syringe injections. The Humalog(®) KwikPen™ (prefilled insulin lispro [Humalog] pen, Eli Lilly and Company, Indianapolis, IN, USA) is a prefilled insulin pen highly rated by patients for ease of use in injections, and has been preferred by patients to both a comparable insulin pen and to vial and syringe injections in comparator studies. Together with an engineering study demonstrating smoother injections and reduced dosing error versus a comparator pen, recent evidence demonstrates the Humalog KwikPen device is an accurate, easy-to-use, patient-preferred insulin pen.

  3. The 1986/1987 Army Communications Objectives Measurement System. Supplementary Tabulations of Officer Markets

    DTIC Science & Technology

    1988-08-01

    ELIGTYPM 1D N~UN 2 ELIGTYP YOUTH’S SAMPLE CELLi oISED ON MAIN 7IT ELIGTYPS 9 rNum 2 ELIGTYP YOUT-i’S SAMPLE CELLf 6AS2ED ON CE.R0 ELIVADOR 112 N~um 2 YESNO...PLOYER I5CCCU*N 214 14jm 2 YZSNO b~ 1d Y CISCUSS COLLzG2 W.T. SC CUNSLV Yaccow 21~ ,1 2 ISU E5~IC~USCCLG DO Y1DC 2~ U Y=S’JO =Eli Y Cscuss CCLL G~ "T...CuqRRENTLY IN MILIT;RlVFA.MNA~ 206 N 1. 2 Y ES N SIt Y M: FAMILY 60ANCH SERVICENAVfYFC;.Sm EG 516 Nim 2 AG; Ezw PE6 GET MONzY FOR EDUCATION: AIR

  4. Observations on Gulf of Alaska seamount chains by multi-beam sonar

    NASA Astrophysics Data System (ADS)

    Smoot, N. Christian

    1985-06-01

    Geomorphic and age data are presented for the Dellwood, Denson, Dickins, Giacomini, and Ely seamounts, the Tsimshian Seachannel, and the southern Juan de Fuca Ridge with Brown Bear, Bear Cub, Grizzly Bear, and Cobb seamounts. Formational speculations extrapolated to a regional scale allow the strikes and outer limits of the seamount chains to be interpreted. Six of these chains are shown in the Gulf of Alaska, none of which conform to the Pratt-Welker or Kodiak-Bowie in the literature. Different strikes show the chains/plate to have rotated 23° about 17 m.y. ago. Morphology also shows that there are four less guyots in the Gulf than previously thought, and that, at least in the Gulf of Alaska, guyot heights do not necessarily reflect sealevel during erosion.

  5. Expert systems and the CPI product substitution review: A needs analysis for the US Bureau of Labor Statistics

    SciTech Connect

    Arrowood, L.F.; Tonn, B.E.

    1992-02-01

    This report presents recommendations relative to the use of expert systems and machine learning techniques by the Bureau of Labor Statistics (BLS) to substantially automate product substitution decisions associated with the Consumer Price Index (CPI). Thirteen commercially available, PC-based expert system shells have received in-depth evaluations. Various machine learning techniques were also reviewed. Two recommendations are given: (1) BLS should use the expert system shell LEVEL5 OBJECT and establish a software development methodology for expert systems; and (2) BLS should undertake a small study to evaluate the potential of machine learning techniques to create and maintain the approximately 350 ELI-specific knowledge bases to be used in CPI product substitution review.

  6. [Bilateral stress fracture of the mid-tibial shaft in a professional dancer].

    PubMed

    Tomčovčík, L; Tomčovčíková, A

    2011-01-01

    Stress fractures of the anterior cortex of the mid-tibial shaft in dancers are rare, with a 1.4 % incidence in injured eli- te dancers. Treatment can be difficult and long-lasting and can seriously influence the dancer's career. The authors pre- sent the case of a 26-year-old professional dancer of a folk dance ensemble who suffered rare simultaneous bilateral mid-tibial shaft stress fractures. A conservative method of treatment with avoiding exercise and dancing activities resulted in the resolution of symptoms and healing of the fractures after 6 months. The patient finished his dancing career because of the necessity of a prolonged therapy interfering with his dancing activities. Current options of the treatment are also presented.

  7. Finite Time Merton Strategy under Drawdown Constraint: A Viscosity Solution Approach

    SciTech Connect

    Elie, R.

    2008-12-15

    We consider the optimal consumption-investment problem under the drawdown constraint, i.e. the wealth process never falls below a fixed fraction of its running maximum. We assume that the risky asset is driven by the constant coefficients Black and Scholes model and we consider a general class of utility functions. On an infinite time horizon, Elie and Touzi (Preprint, [2006]) provided the value function as well as the optimal consumption and investment strategy in explicit form. In a more realistic setting, we consider here an agent optimizing its consumption-investment strategy on a finite time horizon. The value function interprets as the unique discontinuous viscosity solution of its corresponding Hamilton-Jacobi-Bellman equation. This leads to a numerical approximation of the value function and allows for a comparison with the explicit solution in infinite horizon.

  8. Interview with Lisa Shipley. Interviewed by Lisa Parks.

    PubMed

    Shipley, Lisa

    2013-08-01

    Lisa Shipley is Vice President of Pharmacokinetics, Pharmacodynamics and Drug Metabolism at Merck Research Laboratories. She is responsible for preclinical and clinical ADME activities and molecular biomarker assay development activities at all Merck research sites and support of all programs from discovery through to post-product launch. Prior to joining Merck in 2008, Shipley spent over 20 years at Eli Lilly and Company in roles of increasing responsibility, including the positions of executive director at Lean Six Sigma and vice president of Drug Disposition, PK/PD and Trial Simulations. Shipley obtained her undergraduate degree from McDaniel College and her doctoral degree in Pharmacology and Toxicology from the University of Maryland at Baltimore. This interview was conducted by Lisa Parks, Assistant Commissioning Editor of Bioanalysis.

  9. Industrial demand side management: A status report

    SciTech Connect

    Hopkins, M.F.; Conger, R.L.; Foley, T.J.

    1995-05-01

    This report provides an overview of and rationale for industrial demand side management (DSM) programs. Benefits and barriers are described, and data from the Manufacturing Energy Consumption Survey are used to estimate potential energy savings in kilowatt hours. The report presents types and examples of programs and explores elements of successful programs. Two in-depth case studies (from Boise Cascade and Eli Lilly and Company) illustrate two types of effective DSM programs. Interviews with staff from state public utility commissions indicate the current thinking about the status and future of industrial DSM programs. A comprehensive bibliography is included, technical assistance programs are listed and described, and a methodology for evaluating potential or actual savings from projects is delineated.

  10. Biomedical Applications for Introductory Physics

    NASA Astrophysics Data System (ADS)

    Tuszynski, J. A.; Dixon, J. M.

    2001-12-01

    Can be utilized in either Algebra or Calculus-based courses and is available either as a standalone text or as a supplement for books like Cutnell PHYSICS, 5e or Halliday, Resnick, & Walker FUNDAMENTALS OF PHYSICS, 6e.> Math level is Algebra & Trigonometry; however, a few examples require the use of integration and differentiation.

  11. Unlike competing supplements, Tuszinski offers both a wealth of engaging biomedical applications as well as quantitative problem-solving. The quantitative problem-solving is presented in the form of worked examples and homework problems. The quantitative problem-solving is presented in the form of worked examples and homework problems. The standard organization facilitates the integration of the material into most introductory courses.

  12. Nuclear photonics at ultra-high counting rates and higher multipole excitations

    SciTech Connect

    Thirolf, P. G.; Habs, D.; Filipescu, D.; Gernhaeuser, R.; Guenther, M. M.; Jentschel, M.; Marginean, N.; Pietralla, N.

    2012-07-09

    Next-generation {gamma} beams from laser Compton-backscattering facilities like ELI-NP (Bucharest)] or MEGa-Ray (Livermore) will drastically exceed the photon flux presently available at existing facilities, reaching or even exceeding 10{sup 13}{gamma}/sec. The beam structure as presently foreseen for MEGa-Ray and ELI-NP builds upon a structure of macro-pulses ({approx}120 Hz) for the electron beam, accelerated with X-band technology at 11.5 GHz, resulting in a micro structure of 87 ps distance between the electron pulses acting as mirrors for a counterpropagating intense laser. In total each 8.3 ms a {gamma} pulse series with a duration of about 100 ns will impinge on the target, resulting in an instantaneous photon flux of about 10{sup 18}{gamma}/s, thus introducing major challenges in view of pile-up. Novel {gamma} optics will be applied to monochromatize the {gamma} beam to ultimately {Delta}E/E{approx}10{sup -6}. Thus level-selective spectroscopy of higher multipole excitations will become accessible with good contrast for the first time. Fast responding {gamma} detectors, e.g. based on advanced scintillator technology (e.g. LaBr{sub 3}(Ce)) allow for measurements with count rates as high as 10{sup 6}-10{sup 7}{gamma}/s without significant drop of performance. Data handling adapted to the beam conditions could be performed by fast digitizing electronics, able to sample data traces during the micro-pulse duration, while the subsequent macro-pulse gap of ca. 8 ms leaves ample time for data readout. A ball of LaBr{sub 3} detectors with digital readout appears to best suited for this novel type of nuclear photonics at ultra-high counting rates.

  13. Development, implementation and critique of a bioethics framework for pharmaceutical sponsors of human biomedical research.

    PubMed

    Van Campen, Luann E; Therasse, Donald G; Klopfenstein, Mitchell; Levine, Robert J

    2015-11-01

    Pharmaceutical human biomedical research is a multi-dimensional endeavor that requires collaboration among many parties, including those who sponsor, conduct, participate in, or stand to benefit from the research. Human subjects' protections have been promulgated to ensure that the benefits of such research are accomplished with respect for and minimal risk to individual research participants, and with an overall sense of fairness. Although these protections are foundational to clinical research, most ethics guidance primarily highlights the responsibilities of investigators and ethics review boards. Currently, there is no published resource that comprehensively addresses bioethical responsibilities of industry sponsors; including their responsibilities to parties who are not research participants, but are, nevertheless key stakeholders in the endeavor. To fill this void, in 2010 Eli Lilly and Company instituted a Bioethics Framework for Human Biomedical Research. This paper describes how the framework was developed and implemented and provides a critique based on four years of experience. A companion article provides the actual document used by Eli Lilly and Company to guide ethical decisions regarding all phases of human clinical trials. While many of the concepts presented in this framework are not novel, compiling them in a manner that articulates the ethical responsibilities of a sponsor is novel. By utilizing this type of bioethics framework, we have been able to develop bioethics positions on various topics, provide research ethics consultations, and integrate bioethics into the daily operations of our human biomedical research. We hope that by sharing these companion papers we will stimulate discussion within and outside the biopharmaceutical industry for the benefit of the multiple parties involved in pharmaceutical human biomedical research.

  14. Design of a large acceptance, high efficiency energy selection system for the ELIMAIA beam-line

    NASA Astrophysics Data System (ADS)

    Schillaci, F.; Maggiore, M.; Andó, L.; Cirrone, G. A. P.; Cuttone, G.; Romano, F.; Scuderi, V.; Allegra, L.; Amato, A.; Gallo, G.; Korn, G.; Leanza, R.; Margarone, D.; Milluzzo, G.; Petringa, G.

    2016-08-01

    A magnetic chicane based on four electromagnetic dipoles is going to be realized by INFN-LNS to be used as an Energy Selection System (ESS) for laser driven proton beams up to 300 MeV and C6+ up to 70 MeV/u. The system will provide, as output, ion beams with a contrallable energy spread varying from 5% up to 20% according to the aperture slit size. Moreover, it has a very wide acceptance in order to ensure a very high transmission efficiency and, in principle, it has been designed to be used also as an active energy modulator. This system is the core element of the ELIMED (ELI-Beamlines MEDical and Multidisciplinary applications) beam transport, dosimetry and irradiation line that will be developed by INFN-LNS (It) and installed at the ELI-Beamlines facility in Prague (Cz). ELIMED will be the first user's open transport beam-line where a controlled laser-driven ion beam will be used for multidisciplinary research. The definition of well specified characteristics, both in terms of performance and field quality, of the magnetic chicane is crucial for the system realization, for the accurate study of the beam dynamics and for the proper matching with the Permanent Magnet Quadrupoles (PMQs) used as a collection system already designed. Here, the design of the magnetic chicane is described in details together with the adopted solutions in order to realize a robust system form the magnetic point of view. Moreover, the first preliminary transport simulations are also described showing the good performance of the whole beam line (PMQs+ESS).

  15. Quantitative evaluation of susceptibility effects caused by dental materials in head magnetic resonance imaging

    NASA Astrophysics Data System (ADS)

    Strocchi, S.; Ghielmi, M.; Basilico, F.; Macchi, A.; Novario, R.; Ferretti, R.; Binaghi, E.

    2016-03-01

    This work quantitatively evaluates the effects induced by susceptibility characteristics of materials commonly used in dental practice on the quality of head MR images in a clinical 1.5T device. The proposed evaluation procedure measures the image artifacts induced by susceptibility in MR images by providing an index consistent with the global degradation as perceived by the experts. Susceptibility artifacts were evaluated in a near-clinical setup, using a phantom with susceptibility and geometric characteristics similar to that of a human head. We tested different dentist materials, called PAL Keramit, Ti6Al4V-ELI, Keramit NP, ILOR F, Zirconia and used different clinical MR acquisition sequences, such as "classical" SE and fast, gradient, and diffusion sequences. The evaluation is designed as a matching process between reference and artifacts affected images recording the same scene. The extent of the degradation induced by susceptibility is then measured in terms of similarity with the corresponding reference image. The matching process involves a multimodal registration task and the use an adequate similarity index psychophysically validated, based on correlation coefficient. The proposed analyses are integrated within a computer-supported procedure that interactively guides the users in the different phases of the evaluation method. 2-Dimensional and 3-dimensional indexes are used for each material and each acquisition sequence. From these, we drew a ranking of the materials, averaging the results obtained. Zirconia and ILOR F appear to be the best choice from the susceptibility artefacts point of view, followed, in order, by PAL Keramit, Ti6Al4V-ELI and Keramit NP.

  16. Sulfur and oxygen isotope study of the Vermont copper belt: evidence of seawater hydrothermal alteration and sulfate reduction in a high-grade metamorphic terrane

    SciTech Connect

    Shanks, W.C. III; Woodruff, L.G.; Slack, J.F.

    1985-01-01

    Massive sulfide deposits of the Orange County copper district, in east-central Vermont, consist of stratiform lenses of pyrrhotite, chalcopyrite, and minor sphalerite within amphibolite-facies rocks of Early Devonian (.) age. The deposits occur at several different stratigraphic levels. The two largest, Elizabeth and Ely, are in quartz-mica schists of the Gile Mountain Formation; the Pike Hill deposit occurs in calcareous quartz-mica schist of the underlying Waits River Formation. Two small deposits (Orange and Gove) are within the Standing Pond Volcanics, a thin tholeiitic amphibolite near the Gile Mountain-Waits River contact. The Elizabeth deposit in particularly distinctive, and contains a suite of unusual wall rocks rich in quartz, carbonate, muscovite, amphibole, phlogopite, tourmaline, spessartine, and sodic plagioclase. Sulfur isotope values at Elizabeth and Ely of 5.1 to 9.1 per thousands contrast with values for Gove (1.9 to 4.2) and Pike Hill (1.5 to 4.6). Disseminated sulfides in amphibolites of the Standing Pond Volcanics have sulfur isotope values in the range -0.1 to 1.7 per thousands, typical of MORB. These data require sulfur contributions to massive sulfide deposits both from basalt and from contemporaneous seawater sulfate sources. Whole-rock (carbonate free) oxygen isotope analyses of host lithologies range from 7.9 per thousands (Standing Pond Volcanics) to 19.9 per thousands (Waits River Formation). Detailed sampling of Elizabeth wall rocks (including those high in B, Na, Mg, Al, Si, Mn) yields a narrow range of oxygen isotope values (11.1 to 14.1); heavier values correlate with higher silica contents. Isotopically light wallrock lithologies are probably due to premetamorphic seawater hydrothermal alteration.

  17. Fatigue properties of a metastable beta-type titanium alloy with reversible phase transformation.

    PubMed

    Li, S J; Cui, T C; Hao, Y L; Yang, R

    2008-03-01

    Due to recent concern about allergic and toxic effects of Ni ions released from TiNi alloy into human body, much attention has been focused on the development of new Ni-free, metastable beta-type biomedical titanium alloys with a reversible phase transformation between the beta phase and the alpha'' martensite. This study investigates the effect of the stress-induced alpha'' martensite on the mechanical and fatigue properties of Ti-24Nb-4Zr-7.6Sn (wt.%) alloy. The results show that the as-forged alloy has a low dynamic Young's modulus of 55GPa and a recoverable tensile strain of approximately 3%. Compared with Ti-6Al-4V ELI, the studied alloy has quite a high low-cycle fatigue strength because of the effective suppression of microplastic deformation by the reversible martensitic transformation. Due to the low critical stress required to induce the martensitic transformation, it has low fatigue endurance comparable to that of Ti-6Al-4V ELI. Cold rolling produces a beta+alpha'' two-phase microstructure that is characterized by regions of nano-size beta grains interspersed with coarse grains containing alpha'' martensite plates. Cold rolling increases fatigue endurance by approximately 50% while decreasing the Young's modulus to 49GPa along the rolling direction but increasing it to 68GPa along the transverse direction. Due to the effective suppression of the brittle isothermal omega phase, balanced properties of high strength, low Young's modulus and good ductility can be achieved through ageing treatment at intermediate temperature.

  18. Allelic Spectra of Risk SNPs Are Different for Environment/Lifestyle Dependent versus Independent Diseases.

    PubMed

    Gorlov, Ivan P; Gorlova, Olga Y; Amos, Christopher I

    2015-07-01

    Genome-wide association studies (GWAS) have generated sufficient data to assess the role of selection in shaping allelic diversity of disease-associated SNPs. Negative selection against disease risk variants is expected to reduce their frequencies making them overrepresented in the group of minor (<50%) alleles. Indeed, we found that the overall proportion of risk alleles was higher among alleles with frequency <50% (minor alleles) compared to that in the group of major alleles. We hypothesized that negative selection may have different effects on environment (or lifestyle)-dependent versus environment (or lifestyle)-independent diseases. We used an environment/lifestyle index (ELI) to assess influence of environmental/lifestyle factors on disease etiology. ELI was defined as the number of publications mentioning "environment" or "lifestyle" AND disease per 1,000 disease-mentioning publications. We found that the frequency distributions of the risk alleles for the diseases with strong environmental/lifestyle components follow the distribution expected under a selectively neutral model, while frequency distributions of the risk alleles for the diseases with weak environmental/lifestyle influences is shifted to the lower values indicating effects of negative selection. We hypothesized that previously selectively neutral variants become risk alleles when environment changes. The hypothesis of ancestrally neutral, currently disadvantageous risk-associated alleles predicts that the distribution of risk alleles for the environment/lifestyle dependent diseases will follow a neutral model since natural selection has not had enough time to influence allele frequencies. The results of our analysis suggest that prediction of SNP functionality based on the level of evolutionary conservation may not be useful for SNPs associated with environment/lifestyle dependent diseases.

  19. Attributes Influencing Insulin Pen Preference Among Caregivers and Patients With Diabetes Who Require Greater Than 20 Units of Mealtime Insulin

    PubMed Central

    Wang, Tao; Conrad, Kenneth A.; van Brunt, Kate; Rees, Tina M.

    2016-01-01

    Background: This study compared patient preference for Humalog® KwikPen™ 200 units/mL (insulin lispro; hereafter, IL 200 pen; Eli Lilly and Company, Indianapolis, IN) versus the Humalog KwikPen 100 units/mL (insulin lispro; hereafter, IL 100 pen; Eli Lilly and Company, Indianapolis, IN) in patients with diabetes requiring >20 units of mealtime insulin and diabetes caregivers. This study also determined which attributes had the greatest influence on pen preference selection. Methods: In this 2-period, crossover, simulated-use study, 106 participants were randomized to 1 of 8 sequences that varied the pen order (IL 100 pen or IL 200 pen) and dosing order (15 units = low dose or 50 units = high dose) for a total of 4 simulated injections. Participants then completed a self-administered questionnaire to select their overall preference between the 2 pens and then rated the importance of 11 pen attributes in contributing to their overall preference. Results: Of the 90 participants expressing an overall preference, significantly more preferred the IL 200 pen to the IL 100 pen (IL 200 pen: 80 respondents; IL 100 pen: 10 respondents; 95% confidence interval [0.81, 0.94], P < .0001). The total amount of insulin in the pen, the ease in pressing the injection button, and the amount of fluid injected were key attributes influencing IL 200 pen preference. Conclusions: Based on these key attributes, the IL 200 pen was significantly preferred over the IL 100 pen by patients with diabetes who require >20 daily mealtime insulin units or diabetes caregivers and may improve the injection experience for these patients. PMID:26920640

  20. ELIMED, future hadrontherapy applications of laser-accelerated beams

    NASA Astrophysics Data System (ADS)

    Cirrone, Giuseppe A. P.; Carpinelli, Massimo; Cuttone, Giacomo; Gammino, Santo; Bijan Jia, S.; Korn, Georg; Maggiore, Mario; Manti, Lorenzo; Margarone, Daniele; Prokupek, Jan; Renis, Marcella; Romano, Francesco; Schillaci, Francesco; Tomasello, Barbara; Torrisi, Lorenzo; Tramontana, Antonella; Velyhan, Andriy

    2013-12-01

    Laser-ion acceleration has recently gained a great interest as an alternative to conventional and more expensive acceleration techniques. These ion beams have desirable qualities such as small source size, high luminosity and small emittance to be used in different fields as Nuclear Physics, Medical Physics, etc. This is very promising specially for the future perspective of a new concept of hadrontherapy based on laser-based devices could be developed, replacing traditional accelerating machines. Before delivering laser-driven beams for treatments they have to be handled, cleaned from unwanted particles and characterized in order to have the clinical requirements. In fact ion energy spectra have exponential trend, almost 100% energy spread and a wide angular divergence which is the biggest issue in the beam transport and, hence, in a wider use of this technology. In order to demonstrate the clinical applicability of laser-driven beams new collaboration between ELI-Beamlines project researchers from Prague (Cz) and a INFN-LNS group from Catania (I) has been already launched and scientists from different countries have already express their will in joining the project. This cooperation has been named ELIMED (MEDical application at ELIBeamlines) and will take place inside the ELI-Beamlines infrastructure located in Prague. This work describes the schedule of the ELIMED project and the design of the energy selector which will be realized at INFN-LNS. The device is an important part of the whole transport beam line which will be realised in order to make the ion beams suitable for medical applications.

  21. Human Subperitoneal Fibroblast and Cancer Cell Interaction Creates Microenvironment That Enhances Tumor Progression and Metastasis

    PubMed Central

    Yokota, Mitsuru; Ishii, Genichiro; Saito, Norio; Aoyagi, Kazuhiko; Sasaki, Hiroki; Ochiai, Atsushi

    2014-01-01

    Backgrounds Peritoneal invasion in colon cancer is an important prognostic factor. Peritoneal invasion can be objectively identified as periotoneal elastic laminal invasion (ELI) by using elastica stain, and the cancer microenvironment formed by the peritoneal invasion (CMPI) can also be observed. Cases with ELI more frequently show distant metastasis and recurrence. Therefore, CMPI may represent a particular milieu that facilitates tumor progression. Pathological and biological investigations into CMPI may shed light on this possibly distinctive cancer microenvironment. Methods We analyzed area-specific tissue microarrays to determine the pathological features of CMPI, and propagated subperitoneal fibroblasts (SPFs) and submucosal fibroblasts (SMFs) from human colonic tissue. Biological characteristics and results of gene expression profile analyses were compared to better understand the peritoneal invasion of colon cancer and how this may form a special microenvironment through the interaction with SPFs. Mouse xenograft tumors, derived by co-injection of cancer cells with either SPFs or SMFs, were established to evaluate their active role on tumor progression and metastasis. Results We found that fibrosis with alpha smooth muscle actin (α-SMA) expression was a significant pathological feature of CMPI. The differences in proliferation and gene expression profile analyses suggested SPFs and SMFs were distinct populations, and that SPFs were characterized by a higher expressions of extracellular matrix (ECM)-associated genes. Furthermore, compared with SMFs, SPFs showed more variable alteration in gene expressions after cancer-cell-conditioned medium stimulation. Gene ontology analysis revealed that SPFs-specific upregulated genes were enriched by actin-binding or contractile-associated genes including α-SMA encoding ACTA2. Mouse xenograft tumors derived by co-injection of cancer cells with SPFs showed enhancement of tumor growth, metastasis, and capacity for