Sample records for avoiding undue influence

  1. Payments to Normal Healthy Volunteers in Phase 1 Trials: Avoiding Undue Influence While Distributing Fairly the Burdens of Research Participation

    PubMed Central

    2009-01-01

    Clinical investigators must engage in just subject recruitment and selection and avoid unduly influencing research participation. There may be tension between the practice of keeping payments to participants low to avoid undue influence and the requirements of justice when recruiting normal healthy volunteers for phase 1 drug studies. By intentionally keeping payments low to avoid unduly influenced participation, investigators, on the recommendation or insistence of institutional review boards, may be targeting or systematically recruiting healthy adult members of lower socio-economic groups for participation in phase 1 studies. Investigators are at risk of routinely failing to fulfill the obligation of justice, which prohibits the systematic targeting and recruiting of subjects for reasons unrelated to the nature of the study. Insofar as we take seriously the obligation to engage in just subject recruitment and selection, I argue that we must acknowledge the implications low payments might have for subject recruitment and selection and examine the effect of low payments. If low payments de facto target the less well-off for phase 1 studies, we must defend the priority ranking of the obligation to avoid undue influence over the obligation of justice or adopt an alternative recruitment approach. This paper identifies a number of alternatives to the current system of low-value payments to research participants. PMID:19190076

  2. How IRBs view and make decisions about coercion and undue influence.

    PubMed

    Klitzman, Robert

    2013-04-01

    Scholars have debated how to define coercion and undue influence, but how institutional review boards (IRBs) view and make decisions about these issues in actual cases has not been explored. I contacted the leadership of 60 US IRBs (every fourth one in the list of the top 240 institutions by National Institutes of Health funding), and interviewed 39 IRB leaders or administrators from 34 of these institutions (response rate=55%), and 7 members. IRBs wrestled with defining of 'coercion' and 'undue inducement', most notably in deciding about participant compensation. IRBs often use these terms synonymously and define undue inducement in varying ways, often wrestling with these issues, relying on 'gut feelings', and seeking compromises. Ambiguities arose, partly reflecting underlying tensions: whether subjects should 'get paid' versus 'volunteer' (ie, whether subjects should be motivated by compensation vs altruism), and whether subjects should be paid differently based on income, given possible resultant selection bias. Lack of consistent standards emerged between and even on single IRBs. Questions arose concerning certain aspects and types of studies; for example, how to view and weigh providing free care in research, whether and how recruitment flyers should mention compensation, and how to avoid coercion in paediatric, developing world, or students research. These data, the first to probe qualitatively how IRBs view and approach questions about coercion, undue influence and participant compensation, and to examine how IRBs have reviewed actual cases, reveal several critical ambiguities and dilemmas, and have vital implications for future practice, education, policy and research.

  3. Identifying and Managing Undue Influence From Family Members in End-of-Life Decisions for Patients With Advanced Cancer.

    PubMed

    Baker, Francis X; Gallagher, Colleen M

    2017-10-01

    Undue influence from family members of patients with advanced cancer remains a serious ethical problem in end-of-life decision making. Despite the wealth of articles discussing the problem of undue influence, little has been written by way of practical guidance to help clinicians identify and effectively manage situations of undue influence. This article briefly lays out how to identify and manage situations of undue influence sensitively and effectively. We explain how undue influence may present itself in the clinic and distinguish it from ethically permissible expressions of relational autonomy. In addition, we lay out a process by which any clinician suspecting undue influence may gather additional information and, if necessary, conduct a family meeting to address the undue influence. It is our hope that by providing clinicians at all levels of patient care with such guidance, they will feel empowered to respond to cases of undue influence when they arise.

  4. 40 CFR Appendix E to Part 58 - Probe and Monitoring Path Siting Criteria for Ambient Air Quality Monitoring

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... scale. For example, according to Figure E-1 of this appendix, if a PM sampler is primarily influenced by..., or lead content). This criterion is designed to avoid undue influences from minor sources. 7 For... Meeting of Transportation Research Board, Washington, DC. January 1978.) 4. Pace, T.G., W.P. Freas, and E...

  5. 40 CFR Appendix E to Part 58 - Probe and Monitoring Path Siting Criteria for Ambient Air Quality Monitoring

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... scale. For example, according to Figure E-1 of this appendix, if a PM sampler is primarily influenced by... criterion is designed to avoid undue influences from minor sources. 7 For microscale CO monitoring sites in... Research Board, Washington, DC. January 1978.) 4. Pace, T.G., W.P. Freas, and E.M. Afify. Quantification of...

  6. Developing an undue influence screening tool for Adult Protective Services.

    PubMed

    Quinn, Mary Joy; Nerenberg, Lisa; Navarro, Adria E; Wilber, Kathleen H

    2017-03-01

    The study purpose was to develop and pilot an undue influence screening tool for California's Adult Protective Services (APS) personnel based on the definition of undue influence enacted into California law January 1, 2014. Methods included four focus groups with APS providers (n = 33), piloting the preliminary tool by APS personnel (n = 15), and interviews with four elder abuse experts and two APS administrators. Social service literature-including existing undue influence models-was reviewed, as were existing screening and assessment tools. Using the information from these various sources, the California Undue Influence Screening Tool (CUIST) was developed. It can be applied to APS cases and potentially adapted for use by other professionals and for use in other states. Implementation of the tool into APS practice, policy, procedures, and training of personnel will depend on the initiative of APS management. Future work will need to address the reliability and validity of CUIST.

  7. Gender bias and judicial decisions of undue influence in testamentary challenges.

    PubMed

    Recupero, Patricia R; Christopher, Paul P; Strong, David R; Price, Marilyn; Harms, Samara E

    2015-03-01

    Allegations of undue influence constitute a common basis for contests of wills. Legal research from the 1990s suggests that gender bias factors significantly into judicial decision-making regarding alleged undue influence and testamentary intent. In this study, we sought to assess whether this bias is present today and to identify any factors that may be associated with it. Probate judges from several jurisdictions in the United States were asked to consider two hypothetical case vignettes drawn from actual published decisions. In our study, the gender of the testator played only a minor role in how judges weighed factors in the decision-making process and, overall, did not significantly influence opinions regarding the presence of undue influence. The specifics of the case and the gender of the judge emerged as the most consistent and robust potential influences on decision-making. Our results suggest that probate rulings involving undue influence are likely to represent a complex interaction of factors involving the testator's and judge's genders and the specifics of individual cases. The implications of these findings are discussed. © 2015 American Academy of Psychiatry and the Law.

  8. Undue influence of weight and shape: is it distinct from body dissatisfaction and concern about weight and shape?

    PubMed

    Wade, T D; Zhu, G; Martin, N G

    2011-04-01

    Three cognitive constructs are risk factors for eating disorders: undue influence of weight and shape, concern about weight and shape, and body dissatisfaction (BD). Undue influence, a diagnostic criterion for eating disorders, is postulated to be closely associated with self-esteem whereas BD is postulated to be closely associated with body mass index (BMI). We understand less about the relationships with concern about weight and shape. The aim of the current investigation was examine the degree of overlap across these five phenotypes in terms of latent genetic and environmental risk factors in order to draw some conclusions about the similarities and differences across the three cognitive variables. A sample of female Australian twins (n=1056, including 348 complete pairs), mean age 35 years (S.D.=2.11, range 28-40), completed a semi-structured interview about eating pathology and self-report questionnaires. An independent pathways model was used to investigate the overlap of genetic and environmental risk factors for the five phenotypes. In terms of variance that was not shared with other phenotypes, self-esteem emerged as being separate, with 100% of its variance unshared with the other phenotypes, followed by undue influence (51%) and then concern (34%), BD (28%) and BMI (32%). In terms of shared genetic risk, undue influence and concern were more closely related than BD, whereas BMI and BD were found to share common sources of risk. With respect to environmental risk factors, concern, BMI and BD were more closely related to each other than to undue influence.

  9. Legal Standards for Brain Death and Undue Influence in Euthanasia Laws.

    PubMed

    Pope, Thaddeus Mason; Okninski, Michaela E

    2016-06-01

    A major appellate court decision from the United States seriously questions the legal sufficiency of prevailing medical criteria for the determination of death by neurological criteria. There may be a mismatch between legal and medical standards for brain death, requiring the amendment of either or both. In South Australia, a Bill seeks to establish a legal right for a defined category of persons suffering unbearably to request voluntary euthanasia. However, an essential criterion of a voluntary decision is that it is not tainted by undue influence, and this Bill falls short of providing adequate guidance to assess for undue influence.

  10. 19 CFR 111.34 - Undue influence upon Department of Homeland Security employees.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 1 2012-04-01 2012-04-01 false Undue influence upon Department of Homeland Security employees. 111.34 Section 111.34 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS BROKERS Duties and Responsibilities of Customs...

  11. 19 CFR 111.34 - Undue influence upon Department of Homeland Security employees.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 1 2014-04-01 2014-04-01 false Undue influence upon Department of Homeland Security employees. 111.34 Section 111.34 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS BROKERS Duties and Responsibilities of Customs...

  12. 19 CFR 111.34 - Undue influence upon Department of Homeland Security employees.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Undue influence upon Department of Homeland Security employees. 111.34 Section 111.34 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS BROKERS Duties and Responsibilities of Customs...

  13. 19 CFR 111.34 - Undue influence upon Department of Homeland Security employees.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 1 2011-04-01 2011-04-01 false Undue influence upon Department of Homeland Security employees. 111.34 Section 111.34 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS BROKERS Duties and Responsibilities of Customs...

  14. 19 CFR 111.34 - Undue influence upon Department of Homeland Security employees.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 1 2013-04-01 2013-04-01 false Undue influence upon Department of Homeland Security employees. 111.34 Section 111.34 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY CUSTOMS BROKERS Duties and Responsibilities of Customs...

  15. 15 CFR 0.735-19 - Reporting undue influence to superiors.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Government position, former Government employment, family relationship, political position, or otherwise, the.... 0.735-19 Section 0.735-19 Commerce and Foreign Trade Office of the Secretary of Commerce EMPLOYEE RESPONSIBILITIES AND CONDUCT Regulatory Limitations Upon Employee Conduct § 0.735-19 Reporting undue influence to...

  16. 24 CFR 905.602 - Program requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., the PHA must enter into a Cooperation Agreement with the applicable local governing body that includes... proportion of minority to nonminority residents in the area. (5) Notwithstanding the foregoing, after... avoid undue concentration of assisted persons in areas containing a high proportion of low-income...

  17. 77 FR 30915 - Empowering Consumers To Prevent and Detect Billing for Unauthorized Charges (“Cramming...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... cramming and make clear the need for additional protection for consumers. DATES: Effective May 24, 2012... strike an appropriate balance between maximizing consumer protection and avoiding imposing undue burdens...), and 403, the Commission's rules are adopted. 28. The Commission's Consumer and Governmental Affairs...

  18. Teaching Linear Algebra: Proceeding More Efficiently by Staying Comfortably within Z

    ERIC Educational Resources Information Center

    Beaver, Scott

    2015-01-01

    For efficiency in a linear algebra course the instructor may wish to avoid the undue arithmetical distractions of rational arithmetic. In this paper we explore how to write fraction-free problems of various types including elimination, matrix inverses, orthogonality, and the (non-normalizing) Gram-Schmidt process.

  19. 75 FR 25981 - Cost Accounting Standards: Harmonization of Cost Accounting Standards 412 and 413 With the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-10

    ...), invites public comments concerning the harmonization of Cost Accounting Standards 412 and 413 with the... cost that is based on currently accrued benefits that have been valued using corporate bond rates... that avoid undue cost or contribution volatility. The Board agrees with the public comments that since...

  20. Patient retention gifts in clinical trials - undue inducement or justified motivational tools?

    PubMed

    Burgess, L J; Sulzer, N

    2011-09-05

    The use of retention gifts in clinical trials has been controversial, with some ethicists maintaining that such gifts represent undue inducement to the trial participants. A study was conducted at TREAD Research, a site-managed organisation based at Tygerberg Hospital, in which 302 participants completed a questionnaire that focused on their opinion with regard to such gifts. The results suggest that these gifts do not influence patients to participate in a clinical trial or influence them to remain on a trial should they wish to withdraw. However, they do act as a useful motivational tool and trial participants appreciate them.

  1. 77 FR 59139 - Prompt Corrective Action, Requirements for Insurance, and Promulgation of NCUA Rules and Regulations

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    ... threshold is used to define a ``complex'' credit union for determining whether risk-based net worth... credit union (FICU) is subject to certain interest rate risk rule requirements. \\1\\ IRPS 03-2, 68 FR... multiple applications, while avoiding undue risk to the National Credit Union Share Insurance Fund (NCUSIF...

  2. Student Loan Debt in Kentucky: An Analysis of Debt Levels and Their Relationship to Earnings for Baccalaureate Degree Holders of Public Universities, 2010-2013

    ERIC Educational Resources Information Center

    Kentucky Council on Postsecondary Education, 2015

    2015-01-01

    Student loans can be a good investment in an individual's future, providing financial access to higher education and improved chances of economic success after college. However, avoiding undue financial obligations and maximizing the return on investment require careful planning and prudent borrowing. Estimating whether the student loan debt…

  3. 40 CFR 26.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  4. 49 CFR 11.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  5. 45 CFR 46.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons. (4... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  6. 49 CFR 11.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  7. 28 CFR 46.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  8. 49 CFR 11.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  9. 34 CFR 97.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  10. 40 CFR 26.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  11. 22 CFR 225.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  12. 45 CFR 46.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons. (4... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  13. 22 CFR 225.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  14. 40 CFR 26.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  15. 28 CFR 46.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  16. 34 CFR 97.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  17. 28 CFR 46.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  18. 22 CFR 225.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  19. 45 CFR 46.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons. (4... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  20. 49 CFR 11.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  1. 45 CFR 46.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons. (4... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  2. 22 CFR 225.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  3. 34 CFR 97.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  4. 34 CFR 97.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  5. 40 CFR 26.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  6. 28 CFR 46.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  7. 7 CFR 1c.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  8. 7 CFR 1c.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  9. 7 CFR 1c.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  10. 7 CFR 1c.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons... coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or...

  11. Hematocrit Causes the Most Significant Error in Point of Care Glucometers

    DTIC Science & Technology

    2009-04-01

    pneumonia, as it permits leakage of pharyngeal secretions around the cuff. In our randomized controlled trial (5) of 165 patients included in the...interven- tion group, only 9 (5%) required reintu- bation. A few of these patients could per- haps benefit of the evaluation proposed by Stocchetti et al...and avoid an undue extubation; the duration of mechanical ventilation for the overall patients , how- ever, would have been certainly much higher. The

  12. Toward a Model of Influence in Persuasive Discussions: Negotiating Quality, Authority, Privilege, and Access within a Student-Led Argument

    ERIC Educational Resources Information Center

    Engle, Randi A.; Langer-Osuna, Jennifer M.; McKinney de Royston, Maxine

    2014-01-01

    It is commonly observed that during classroom or group discussions some students have greater influence than may be justified by the normative quality of those students' contributions. We propose a 5-component theoretical framework in order to explain how undue influence unfolds. We build on literatures on persuasion, argumentation, discourse, and…

  13. 15 CFR 12.2 - Undue proliferation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., he shall initiate an inquiry for the purpose of finding facts concerning the existence of undue... possible existence of undue proliferation. Such communications should be in writing and include supporting... regarding the possible existence of undue proliferation, the Secretary will determine whether there has been...

  14. 15 CFR 12.2 - Undue proliferation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., he shall initiate an inquiry for the purpose of finding facts concerning the existence of undue... possible existence of undue proliferation. Such communications should be in writing and include supporting... regarding the possible existence of undue proliferation, the Secretary will determine whether there has been...

  15. 25 CFR 141.31 - Trade by Indian Affairs employees restricted.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... organization. (b) Lease or sale of home sites or allotments on trust or restricted Indian land to or from... (or affirm) that I have not exercised any undue influence nor used any special knowledge received by...

  16. 49 CFR 835.3 - Scope of permissible testimony.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...., 2d Sess., 44 (1974), and serve to ensure that the Board does not exert an undue influence on... admitted in evidence or used in a deposition approved under this part. (e) Not all material in a factual...

  17. 49 CFR 835.3 - Scope of permissible testimony.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...., 2d Sess., 44 (1974), and serve to ensure that the Board does not exert an undue influence on... admitted in evidence or used in a deposition approved under this part. (e) Not all material in a factual...

  18. 49 CFR 835.3 - Scope of permissible testimony.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...., 2d Sess., 44 (1974), and serve to ensure that the Board does not exert an undue influence on... admitted in evidence or used in a deposition approved under this part. (e) Not all material in a factual...

  19. 49 CFR 835.3 - Scope of permissible testimony.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...., 2d Sess., 44 (1974), and serve to ensure that the Board does not exert an undue influence on... admitted in evidence or used in a deposition approved under this part. (e) Not all material in a factual...

  20. 49 CFR 835.3 - Scope of permissible testimony.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...., 2d Sess., 44 (1974), and serve to ensure that the Board does not exert an undue influence on... admitted in evidence or used in a deposition approved under this part. (e) Not all material in a factual...

  1. 15 CFR 27.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... populations, such as children, prisoners, pregnant women, mentally disabled persons, or economically or... subjects are likely to be vulnerable to coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons, additional...

  2. 16 CFR 1028.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... populations, such as children, prisoners, pregnant women, mentally disabled persons, or economically or... subjects are likely to be vulnerable to coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons, additional...

  3. 15 CFR 27.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... populations, such as children, prisoners, pregnant women, mentally disabled persons, or economically or... subjects are likely to be vulnerable to coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons, additional...

  4. 15 CFR 27.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... populations, such as children, prisoners, pregnant women, mentally disabled persons, or economically or... subjects are likely to be vulnerable to coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons, additional...

  5. 16 CFR 1028.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... populations, such as children, prisoners, pregnant women, mentally disabled persons, or economically or... subjects are likely to be vulnerable to coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons, additional...

  6. 15 CFR 27.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... populations, such as children, prisoners, pregnant women, mentally disabled persons, or economically or... subjects are likely to be vulnerable to coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons, additional...

  7. 14 CFR 1230.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... populations, such as children, prisoners, pregnant women, mentally disabled persons, or economically or... subjects are likely to be vulnerable to coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons, additional...

  8. 14 CFR 1230.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... populations, such as children, prisoners, pregnant women, mentally disabled persons, or economically or... subjects are likely to be vulnerable to coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons, additional...

  9. 16 CFR 1028.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... populations, such as children, prisoners, pregnant women, mentally disabled persons, or economically or... subjects are likely to be vulnerable to coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons, additional...

  10. 16 CFR § 1028.111 - Criteria for IRB approval of research.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... populations, such as children, prisoners, pregnant women, mentally disabled persons, or economically or... subjects are likely to be vulnerable to coercion or undue influence, such as children, prisoners, pregnant women, mentally disabled persons, or economically or educationally disadvantaged persons, additional...

  11. Management of pyothorax.

    PubMed

    Holmberg, D L

    1979-05-01

    Pyothorax is a serious disease process which requires both medical and surgical intervention. Late recognition, management problems, and likely recurrence make successful treatment difficult and often frustrating. Aims of therapy should be to avoid undue stress to the patient, to relieve respiratory distress by thoracocentesis, to eliminate infectious agents with antimicrobials, to remove pleural exudate, and to provide supportive care. Close monitoring of the patient is necessary to prevent iatrogenic complications such as pneumothorax, hemothorax, hypothermia, or hypoproteinemia. Exploratory thoracotomy for removal of granulomatous material and fibroelastic pleural "peels" is occasionally necessary to resolve compressive cardiopulmonary lesions.

  12. 76 FR 69481 - Testing and Labeling Pertaining to Product Certification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-08

    ... material change in the product's design or manufacturing process, including the sourcing of component parts... the product's design or manufacturing process and safeguarding against the exercise of undue influence..., such as proposed Sec. 1107.23(a) regarding ``material change'' in the product's design, manufacturing...

  13. 39 CFR 447.61 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false General. 447.61 Section 447.61 Postal Service UNITED STATES POSTAL SERVICE PERSONNEL RULES OF CONDUCT FOR POSTAL EMPLOYEES Bribery, Undue Influence, or... employee to act or neglect to act in regard to his official responsibilities; and (2) Any information that...

  14. 48 CFR 904.7003 - Disclosure of foreign ownership, control, or influence.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... undue risk to the common defense and security through the possible compromise of that information or material. If the DOE determines that such a threat or potential threat exists, the contracting officer... the DOE to obtain information about FOCI which is sufficient to help the Department determine whether...

  15. Federal Funds and State Interests: A Proposal for Governing the NAEP.

    ERIC Educational Resources Information Center

    Doyle, Denis P.

    1983-01-01

    Informational, diagnostic, prescriptive functions of National Assessment of Educational Progress (NAEP) are best served by governance structure composed of federal, state, and local members and a standing technical advisory board. Structure protects NAEP from undue federal influence and special interest groups, builds bridges to educators and…

  16. Vulnerabilities to misinformation in online pharmaceutical marketing.

    PubMed

    De Freitas, Julian; Falls, Brian A; Haque, Omar S; Bursztajn, Harold J

    2013-05-01

    Given the large percentage of Internet users who search for health information online, pharmaceutical companies have invested significantly in online marketing of their products. Although online pharmaceutical marketing can potentially benefit both physicians and patients, it can also harm these groups by misleading them. Indeed, some pharmaceutical companies have been guilty of undue influence, which has threatened public health and trust. We conducted a review of the available literature on online pharmaceutical marketing, undue influence and the psychology of decision-making, in order to identify factors that contribute to Internet users' vulnerability to online pharmaceutical misinformation. We find five converging factors: Internet dependence, excessive trust in the veracity of online information, unawareness of pharmaceutical company influence, social isolation and detail fixation. As the Internet continues to change, it is important that regulators keep in mind not only misinformation that surrounds new web technologies and their contents, but also the factors that make Internet users vulnerable to misinformation in the first place. Psychological components are a critical, although often neglected, risk factor for Internet users becoming misinformed upon exposure to online pharmaceutical marketing. Awareness of these psychological factors may help Internet users attentively and safely navigate an evolving web terrain.

  17. Vulnerabilities to misinformation in online pharmaceutical marketing

    PubMed Central

    De Freitas, Julian; Falls, Brian A; Haque, Omar S; Bursztajn, Harold J

    2013-01-01

    Given the large percentage of Internet users who search for health information online, pharmaceutical companies have invested significantly in online marketing of their products. Although online pharmaceutical marketing can potentially benefit both physicians and patients, it can also harm these groups by misleading them. Indeed, some pharmaceutical companies have been guilty of undue influence, which has threatened public health and trust. We conducted a review of the available literature on online pharmaceutical marketing, undue influence and the psychology of decision-making, in order to identify factors that contribute to Internet users’ vulnerability to online pharmaceutical misinformation. We find five converging factors: Internet dependence, excessive trust in the veracity of online information, unawareness of pharmaceutical company influence, social isolation and detail fixation. As the Internet continues to change, it is important that regulators keep in mind not only misinformation that surrounds new web technologies and their contents, but also the factors that make Internet users vulnerable to misinformation in the first place. Psychological components are a critical, although often neglected, risk factor for Internet users becoming misinformed upon exposure to online pharmaceutical marketing. Awareness of these psychological factors may help Internet users attentively and safely navigate an evolving web terrain. PMID:23761527

  18. Pathways of undue influence in health policy-making: a main actor's perspective.

    PubMed

    Hernández-Aguado, Ildefonso; Chilet-Rosell, Elisa

    2018-02-01

    It is crucial to know the extent to which influences lead to policy capture-by which the policy-making process is shifted away from the public interest towards narrow private interests. Using the case study of Spain, our aim was to identify interactions between public administration, civil society and private companies that could influence health policies. 54 semistructured interviews with key actors related to health policy. The interviews were used to gather information on main policy actors as well as on direct and subtle influences that could modify health policies. The analysis identified and described, from the interviewed persons' experiences, both the inappropriate influences exerted on the actors and those that they exerted. Inappropriate influences were identified at all levels of administration and policy. They included actions for personal benefits, pressure for blocking health policies and pressure from high levels of government in favour of private corporations. The private sector played a significant role in these strategies through bribery, personal gifts, revolving doors, negative campaigns and by blocking unfavourable political positions or determining the knowledge agenda. The interviewees reported subtle forms of influence (social events, offers of technical support, invitations, etc) that contributed to the intellectual and cultural capture of health officials. The health policy decision-making processes in Spain are subject to influences by stakeholders that determine a degree of policy capture, which is avoidable. The private sector uses different strategies, from subtle influences to outright corruption, taking advantage in many cases of flexible legislation. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  19. Cost implications for changing candidacy or access to service within a publicly funded healthcare system?

    PubMed

    O'Neill, Ciaran; Lamb, Brian; Archbold, Sue

    2016-04-01

    Undue attention in the allocation of healthcare resources can be given to expenditures as opposed to expenditures avoided. This can be particularly apparent when expenditures avoided fall across different budget holders and budgetary pressures are strained. The paper presents estimates of the potential savings attributable to the adoption of new hearing assistive technologies in Britain between 1992 and 2014 based on multivariate analyses of survey data. The reduction in service use among the hearing impaired between 1992 and 2014 is estimated to amount to between £53 and £92 million per annum. Issues in estimating the impact of widening candidature for cochlear implants on costs exist related to potential savings. This research begins to lay a firmer evidence base for such work as well as identifying some of the challenges.

  20. 49 CFR 37.155 - Factors in decision to grant an undue financial burden waiver.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Service § 37.155 Factors in decision to grant an undue financial burden waiver. (a) In making an undue... reduction in service, measured by service miles; (2) Average number of trips made by the entity's general... and quality of available resources for complementary paratransit service; and (10) Unique...

  1. Capacity to consent to research among patients with bipolar disorder.

    PubMed

    Misra, Sahana; Ganzini, Linda

    2004-06-01

    Experts have debated the influence of mental illness on decision-making capacity. This paper reviews concepts of decision-making capacity and existing research on the influence of mental illness on capacity to consent to research. We propose how bipolar disorder, especially mania, may have an effect on consent capacity. The current conceptualization of capacity utilizes legal standards of 'choice', 'understanding', 'appreciation' and 'rational reasoning', as well as voluntarism, or the assurance that the patient is free to agree or to decline to participate in research. Studies of patients with schizophrenia suggest impaired cognition influences 'understanding' and is more important than severity of psychosis in affecting decision-making abilities. There are no studies of sources and extent of impairment to consent to research among manic patients. Mania may influence a patient's understanding of the research protocol, but also alter the patient's views, values and level of insight, thus impairing decision-making abilities at the 'appreciation' standard even when the patient understands the relevant information. Mania may impact freedom to decide, yet paradoxically, manic patients may be less influenced by others and less vulnerable to coercion, undue influence and undue incentives compared to patients without mental illness. We suggest that in patients with mood disorders, the legal standard of appreciation be thoroughly probed during the consent procedure. Studies of the effect of mania and depression on consent capacity and voluntarism are needed in order to develop processes that increase safeguards in the informed consent process.

  2. 3 CFR - Lobbyists on Agency Boards and Commissions

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 3 The President 1 2011-01-01 2011-01-01 false Lobbyists on Agency Boards and Commissions Presidential Documents Other Presidential Documents Memorandum of June 18, 2010 Lobbyists on Agency Boards and Commissions Memorandum for the Heads of Executive Departments and Agencies My Administration is committed to reducing the undue influence of specia...

  3. 43 CFR 3809.401 - Where do I file my plan of operations and what information must I include with it?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... would not result in unnecessary or undue degradation of public lands. (b) Your plan of operations must... BLM to determine that the plan of operations prevents unnecessary or undue degradation: (1) Operator... closure (including periods of seasonal closure) to prevent unnecessary or undue degradation. The interim...

  4. Assessing the Performance Management of National Preparedness - A Conceptual Model

    DTIC Science & Technology

    2015-12-01

    biased outcomes with “ambiguous and uncertain preparedness goals, a lack of agreement about what the measures should aim at and how they should be...there may also be undue influence, either intentionally or subconsciously , on how the data is presented. These influences are caused by the...ensure that data are free of systematic error or bias , and that what is intended to be measured is actually measured.”349 This step is critical to

  5. What are fair study benefits in international health research? Consulting community members in Kenya.

    PubMed

    Njue, Maureen; Kombe, Francis; Mwalukore, Salim; Molyneux, Sassy; Marsh, Vicki

    2014-01-01

    Planning study benefits and payments for participants in international health research in low- income settings can be a difficult and controversial process, with particular challenges in balancing risks of undue inducement and exploitation and understanding how researchers should take account of background inequities. At an international health research programme in Kenya, this study aimed to map local residents' informed and reasoned views on the effects of different levels of study benefits and payments to inform local policy and wider debates in international research. Using a relatively novel two-stage process community consultation approach, five participatory workshops involving 90 local residents from diverse constituencies were followed by 15 small group discussions, with components of information-sharing, deliberation and reflection to situate normative reasoning within debates. Framework Analysis drew inductively and deductively on voice-recorded discussions and field notes supported by Nvivo 10 software, and the international research ethics literature. Community members' views on study benefits and payments were diverse, with complex contextual influences and interplay between risks of giving 'too many' and 'too few' benefits, including the role of cash. While recognising important risks for free choice, research relationships and community values in giving 'too many', the greatest concerns were risks of unfairness in giving 'too few' benefits, given difficulties in assessing indirect costs of participation and the serious consequences for families of underestimation, related to perceptions of researchers' responsibilities. Providing benefits and payments to participants in international research in low-income settings is an essential means by which researchers meet individual-level and structural forms of ethical responsibilities, but understanding how this can be achieved requires a careful account of social realities and local judgment. Concerns about undue inducement in low-income communities may often be misplaced; we argue that greater attention should be placed on avoiding unfairness, particularly for the most-poor.

  6. What Are Fair Study Benefits in International Health Research? Consulting Community Members in Kenya

    PubMed Central

    Njue, Maureen; Kombe, Francis; Mwalukore, Salim; Molyneux, Sassy; Marsh, Vicki

    2014-01-01

    Background Planning study benefits and payments for participants in international health research in low- income settings can be a difficult and controversial process, with particular challenges in balancing risks of undue inducement and exploitation and understanding how researchers should take account of background inequities. At an international health research programme in Kenya, this study aimed to map local residents' informed and reasoned views on the effects of different levels of study benefits and payments to inform local policy and wider debates in international research. Methods and Findings Using a relatively novel two-stage process community consultation approach, five participatory workshops involving 90 local residents from diverse constituencies were followed by 15 small group discussions, with components of information-sharing, deliberation and reflection to situate normative reasoning within debates. Framework Analysis drew inductively and deductively on voice- recorded discussions and field notes supported by Nvivo 10 software, and the international research ethics literature. Community members' views on study benefits and payments were diverse, with complex contextual influences and interplay between risks of giving ‘too many’ and ‘too few’ benefits, including the role of cash. While recognising important risks for free choice, research relationships and community values in giving ‘too many’, the greatest concerns were risks of unfairness in giving ‘too few’ benefits, given difficulties in assessing indirect costs of participation and the serious consequences for families of underestimation, related to perceptions of researchers' responsibilities. Conclusions Providing benefits and payments to participants in international research in low-income settings is an essential means by which researchers meet individual-level and structural forms of ethical responsibilities, but understanding how this can be achieved requires a careful account of social realities and local judgment. Concerns about undue inducement in low-income communities may often be misplaced; we argue that greater attention should be placed on avoiding unfairness, particularly for the most-poor. PMID:25470596

  7. 77 FR 76099 - Yorkville ETF Trust and Yorkville ETF Advisors, LLC; Notice of Application

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... given trading day, or from day to day, such variances occur as a result of third party market forces... that the proposed distribution system will be orderly because competitive forces will ensure that the... include concerns about undue influence by a fund of funds over underlying funds, excessive layering of...

  8. High School World History Textbooks: An Analysis of Content Focus and Chronological Approaches

    ERIC Educational Resources Information Center

    Marino, Michael P.

    2011-01-01

    Research about social studies textbooks overwhelmingly supports the conclusion that these books are unpopular and often the subject of intense criticisms. These criticisms concern anything ranging from the language they employ, to the way they are utilized by teachers, to the undue influence they exert on shaping and defining curriculum. This…

  9. Concepts of Integration for UAS Operations in the NAS

    NASA Technical Reports Server (NTRS)

    Consiglio, Maria C.; Chamberlain, James P.; Munoz, Cesar A.; Hoffler, Keith D.

    2012-01-01

    One of the major challenges facing the integration of Unmanned Aircraft Systems (UAS) in the National Airspace System (NAS) is the lack of an onboard pilot that can comply with the legal requirement identified in the US Code of Federal Regulations (CFR) that pilots see and avoid other aircraft. UAS will be expected to demonstrate the means to perform the function of see and avoid while preserving the safety level of the airspace and the efficiency of the air traffic system. This paper introduces a Sense and Avoid (SAA) concept for integration of UAS into the NAS that is currently being developed by the National Aeronautics and Space Administration (NASA) and identifies areas that require additional experimental evaluation to further inform various elements of the concept. The concept design rests on interoperability principles that take into account both the Air Traffic Control (ATC) environment as well as existing systems such as the Traffic Alert and Collision Avoidance System (TCAS). Specifically, the concept addresses the determination of well clear values that are large enough to avoid issuance of TCAS corrective Resolution Advisories, undue concern by pilots of proximate aircraft and issuance of controller traffic alerts. The concept also addresses appropriate declaration times for projected losses of well clear conditions and maneuvers to regain well clear separation.

  10. Women on the Frontlines of Peace and Security

    DTIC Science & Technology

    2014-01-01

    of those profits, thus wielding undue influence and undermining those who wish to enforce legislation . illicit funds—from both narcotics and...environments where these relationships occur. The greater our environmental knowledge and extent of our relationships, the more likely we are to be...taboo. Depending on location, forced engagement between sexes can instantly destroy months of gained and invaluable trust. Through environmental

  11. Guidance and Ethical Considerations for Undertaking Transgender Health Research and Institutional Review Boards Adjudicating this Research

    PubMed Central

    Adams, Noah; Pearce, Ruth; Veale, Jaimie; Radix, Asa; Castro, Danielle; Sarkar, Amrita; Thom, Kai Cheng

    2017-01-01

    Abstract The purpose of this review is to create a set of provisional criteria for Institutional Review Boards (IRBs) to refer to when assessing the ethical orientation of transgender health research proposals. We began by searching for literature on this topic using databases and the reference lists of key articles, resulting in a preliminary set of criteria. We then collaborated to develop the following nine guidelines: (1) Whenever possible, research should be grounded, from inception to dissemination, in a meaningful collaboration with community stakeholders; (2) language and framing of transgender health research should be non-stigmatizing; (3) research should be disseminated back to the community; (4) the diversity of the transgender and gender diverse (TGGD) community should be accurately reflected and sensitively reflected; (5) informed consent must be meaningful, without coercion or undue influence; (6) the protection of participant confidentiality should be paramount; (7) alternative consent procedures should be considered for TGGD minors; (8) research should align with current professional standards that refute conversion, reorientation, or reparative therapy; and (9) IRBs should guard against the temptation to avoid, limit, or delay research on this subject. PMID:29098202

  12. 18 CFR 294.101 - Shortages of electric energy and capacity.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... without undue prejudice or disadvantage; and (ii) It shall also identify any agreement, law, or regulation... treat without undue discrimination or preference, prejudice, or disadvantage firm power wholesale...

  13. Voting Assistance Guide 82

    DTIC Science & Technology

    1982-01-01

    some- one else by an announced deadline. This is not always guaranteed. The best way for a voter to prevent disen- franchisement due to BALLOT...Board of Election Commissioners citr Aurorm Bloomington Chicago DanviU« E. St. LouU Ualwburi Peoria Rockford Springlleld DuPag« AMran Zip Cafe ...governmental operations, shall constitute a violation of any provision of law relating to the elective franchise . Sec. 197Sce-25. Undue influenc

  14. 5 CFR 575.208 - Approval criteria and written determination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... undue disruption of an activity or function that is deemed essential to the agency's mission or without undue disruption of service to the public. (2) The written determination under paragraph (a) of this...

  15. Roundup litigation discovery documents: implications for public health and journal ethics.

    PubMed

    Krimsky, Sheldon; Gillam, Carey

    2018-06-08

    This paper reviews the court-released discovery documents obtained from litigation against Monsanto over its herbicide Roundup and through Freedom of Information Act requests (requests to regulatory agencies and public universities in the United States). We sought evidence of corporate malfeasance and undisclosed conflicts of interest with respect to issues of scientific integrity. The findings include evidence of ghostwriting, interference in journal publication, and undue influence of a federal regulatory agency.

  16. 7 CFR 15b.13 - Reasonable accommodation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) A recipient shall make reasonable accommodation to the known physical or mental limitations of an... accommodation would impose an undue hardship on the operation of its program or activity. (b) Reasonable... undue hardship on the operation of a recipient's programs or activities, factors to be considered...

  17. 10 CFR 1040.67 - Reasonable accommodation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... known physical or mental limitations of an otherwise qualified handicapped applicant or employee unless the recipient can demonstrate that the accommodation would impose an undue hardship on the operation... accommodation would impose an undue hardship on the operation of a recipient's program or activity, factors to...

  18. 45 CFR 84.12 - Reasonable accommodation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... physical or mental limitations of an otherwise qualified handicapped applicant or employee unless the recipient can demonstrate that the accommodation would impose an undue hardship on the operation of its... an accommodation would impose an undue hardship on the operation of a recipient's program or activity...

  19. 45 CFR 1232.10 - Reasonable accommodation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... shall make reasonable accommodation to the known physical or mental limitations of an otherwise... accommodation would impose an undue hardship on the operation of its program or activity. (b) Reasonable... would impose an undue hardship on the operation of a recipient's program or activity, factors to be...

  20. Unusual Presentation of Chronic Idiopathic Thrombocytopenic Purpura

    PubMed Central

    Madhusudhanan, M.; Yusuff, Ali M.

    2008-01-01

    A snakebite victim presented with normal clotting profile and a low platelet count. A routine CBC in his past records (February 2004) showed a platelet count of 20,000/microlitre, but the patient was not symptomatic. We report a case of chronic idiopathic thrombocytopenic purpura, incidentally found in a patient presenting with snakebite. The patient also has acquired primary testicular failure. After the diagnosis the patient was on regular follow up. He caused trauma to the right external auditory canal and perforated his tympanic membrane. His left tympanic membrane was also scarred and retracted. Establishing a diagnosis of an ITP early is important so that the patient can take precaution to avoid undue trauma and monitor proper follow up. PMID:22567212

  1. 38 CFR 18.412 - Reasonable accommodation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... known physical or mental limitations of a handicapped applicant or employee if such accommodation would... that the accommodation would impose an undue hardship on the operation of its program or activity. (b... impose an undue hardship on the operation of a recipient's program or activity, factors to be considered...

  2. 43 CFR 17.211 - Reasonable accommodation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Reasonable accommodation. (a) A recipient shall make reasonable accommodation to the known physical or mental... that the accommodation would impose an undue hardship on the operation of its program or activity. (b... accommodation would impose an undue hardship on the operation of a recipient's program or activity, factors to...

  3. 22 CFR 217.12 - Reasonable accommodation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... accommodation. (a) A recipient shall make reasonable accommodation to the known physical or mental limitations... the accommodation would impose an undue hardship on the operation of its program or activity. (b... would impose an undue hardship on the operation of a recipient's program or activity, factors to be...

  4. 18 CFR 157.35 - Undue discrimination or preference.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Undue discrimination or preference. 157.35 Section 157.35 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY... Fast Track Processing procedures contained in § 385.206(h). (c) Each prospective applicant conducting...

  5. Private Sector Engagement: An Approach

    NASA Astrophysics Data System (ADS)

    Benjamin, G.

    2016-12-01

    Public health organizations serve as scientific societies as a major part of their core mission. In addition, mobilizing partners to identify health threats and to work collaboratively to improve community health involves engagement of a variety of partners including those in the private sector. Increased concerns about conflicts of interest, transparency and undue influence are emerging as a major concern. This presentation will explore one framework for decision making to minimize risks and enhancing independence in scientific inquiry and public health programming.

  6. 16 CFR 1119.4 - Factors considered in determining civil penalties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) The appropriateness of such penalty in relation to the size of the business of the person charged, including how to mitigate undue adverse economic impacts on small businesses; and (F) Such other factors as... relation to the size of the business of the person charged, including how to mitigate undue adverse...

  7. Relational autonomy or undue pressure? Family's role in medical decision-making.

    PubMed

    Ho, Anita

    2008-03-01

    The intertwining ideas of self-determination and well-being have received tremendous support in western bioethics. They have been used to reject medical paternalism and to justify patients' rights to give informed consent (or refusal) and execute advanced directives. It is frequently argued that everyone is thoroughly unique, and as patients are most knowledgeable of and invested in their own interests, they should be the ones to make voluntary decisions regarding their care. Two results of the strong focus on autonomy are the rejection of the image of patients as passive care recipients and the suspicion against paternalistic influence anyone may have on patients' decision-making process. Although the initial focus in western bioethics was on minimizing professional coercion, there has been a steady concern of family's involvement in adult patients' medical decision-making. Many worry that family members may have divergent values and priorities from those of the patients, such that their involvement could counter patients' autonomy. Those who are heavily involved in competent patients' decision-making are often met with suspicion. Patients who defer to their families are sometimes presumed to be acting out of undue pressure. This essay argues for a re-examination of the notions of autonomy and undue pressure in the contexts of patienthood and relational identity. In particular, it examines the characteristics of families and their role in adult patients' decision-making. Building on the feminist conception of the relational self and examining the context of contemporary institutional medicine, this paper argues that family involvement and consideration of family interests can be integral in promoting patients' overall agency. It argues that, in the absence of abuse and neglect, respect for autonomy and agency requires clinicians to abide by patients' expressed wishes.

  8. [Extramural research funds and penal law--status of legislation].

    PubMed

    Ulsenheimer, Klaus

    2005-04-01

    After decades of smooth functioning, the cooperation of physicians and hospitals with the industry (much desired from the side of the government in the interest of clinical research) has fallen in legal discredit due to increasingly frequent criminal inquires and proceedings for unduly privileges, corruption, and embezzlement. The discredit is so severe that the industry funding for clinical research is diverted abroad to an increasing extent. The legal elements of embezzlement assume the intentional violation of the entrusted funds against the interest of the customer. Undue privileges occur when an official requests an advantage in exchange for a service (or is promised one or takes one) in his or somebody else's interest. The elements of corruption are then given when the receiver of the undue privilege provides an illegal service or takes a discretionary decision under the influence of the gratuity. The tension between the prohibition of undue privileges (as regulated by the penal law) and the granting of extramural funds (as regulated by the administrative law in academic institutions) can be reduced through a high degree of transparency and the start of control possibilities--public announcement and authorization by the officials--as well as through exact documentation and observance of the principles of separation of interests and moderation. With the anti-corruption law of 1997, it is possible to charge of corruption also physicians employed in private institutions. In contrast, physicians in private practice are not considered in the above criminal facts. They can only be charged of misdemeanor, or called to respond to the professional board, on the basis of the law that regulates advertising for medicinal products (Heilmittelwerbegesetz).

  9. Personnel Security Clearances: Additional Guidance and Oversight Needed at DHS and DOD to Ensure Consistent Application of Revocation Process

    DTIC Science & Technology

    2014-09-01

    component, which provides an important check against unfairness and the taint of undue influence. These officials stated that having decision makers...removals, suspensions of more than 14 days, reductions in grade or pay , furloughs of 30 days or less, performance-based removals or reductions in grade...denials of within-grade salary increases, reduction-in-force actions, and OPM suitability determinations. 70See Department of Navy v. Egan, 484 U.S

  10. 76 FR 802 - Florida Power and Light Company, Turkey Point, Units 3 and 4; Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-06

    ..., health physics, chemistry, and security, to maintain the safe and secure operation of the facility. The... exemption is authorized by law. No Undue Risk to Public Health and Safety The underlying purposes of 10 CFR... previously evaluated. Therefore, there is no undue risk to public health and safety. Consistent With Common...

  11. 50 CFR 14.33 - Permits to import or export wildlife at nondesignated port to alleviate undue economic hardship.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 1 2012-10-01 2012-10-01 false Permits to import or export wildlife at nondesignated port to alleviate undue economic hardship. 14.33 Section 14.33 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR TAKING, POSSESSION, TRANSPORTATION, SALE...

  12. 50 CFR 14.33 - Permits to import or export wildlife at nondesignated port to alleviate undue economic hardship.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 1 2011-10-01 2011-10-01 false Permits to import or export wildlife at nondesignated port to alleviate undue economic hardship. 14.33 Section 14.33 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR TAKING, POSSESSION, TRANSPORTATION, SALE...

  13. 50 CFR 14.33 - Permits to import or export wildlife at nondesignated port to alleviate undue economic hardship.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 1 2014-10-01 2014-10-01 false Permits to import or export wildlife at nondesignated port to alleviate undue economic hardship. 14.33 Section 14.33 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR TAKING, POSSESSION, TRANSPORTATION, SALE...

  14. 50 CFR 14.33 - Permits to import or export wildlife at nondesignated port to alleviate undue economic hardship.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Permits to import or export wildlife at nondesignated port to alleviate undue economic hardship. 14.33 Section 14.33 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR TAKING, POSSESSION, TRANSPORTATION, SALE...

  15. 50 CFR 14.33 - Permits to import or export wildlife at nondesignated port to alleviate undue economic hardship.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 1 2013-10-01 2013-10-01 false Permits to import or export wildlife at nondesignated port to alleviate undue economic hardship. 14.33 Section 14.33 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR TAKING, POSSESSION, TRANSPORTATION, SALE...

  16. 29 CFR 1605.2 - Reasonable accommodation without undue hardship as required by section 701(j) of title VII of the...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... BECAUSE OF RELIGION § 1605.2 Reasonable accommodation without undue hardship as required by section 701(j... address other obligations under title VII not to discriminate on grounds of religion, nor other provisions... intended to provide guidance for statutes which require accommodation on bases other than religion such as...

  17. Paying Research Participants: Regulatory Uncertainty, Conceptual Confusion, and a Path Forward.

    PubMed

    Largent, Emily A; Fernandez Lynch, Holly

    The practice of offering payment to individuals in exchange for their participation in clinical research is widespread and longstanding. Nevertheless, such payment remains the source of substantial debate, in particular about whether or the extent to which offers of payment coerce and/or unduly induce individuals to participate. Yet, the various laws, regulations, and ethical guidelines that govern the conduct of human subjects research offer relatively little in the way of specific guidance regarding what makes a payment offer ethically acceptable-or not. Moreover, there is a lack of definitional agreement regarding what the terms coercion and undue inducement mean in the human subjects research context. It is, therefore, unsurprising that investigators and Institutional Review Boards (IRBs) experience confusion about how to evaluate offers of payment, and lean toward conservative approaches. These trends are exemplified by our pilot data regarding the ways in which some IRB members and investigators (mis)understand the concepts of coercion and undue inducement, as well as the ways in which certain research institutions oversee offers of payment at a local level. This article systematically examines the legal and ethical dimensions of offering payment to research participants. It argues that many concerns about offers of payment to research participants can be attributed to the misguided view that such offers ought to be treated differently than offers of payment in other contexts, a form of "research exceptionalism." We show that rejection of research exceptionalism with respect to payment helps settle open debates about both how best to define coercion and undue influence, and how to understand the relation between these concepts and offers of payment. We argue for adoption of our preferred definitions, ideally by regulatory authorities, and against the conventional conservatism toward payment of research participants. Instead, we draw attention to the rarely asked, even radical, question: are research participants paid enough ? We conclude by arguing that we ought to change the default to favor, rather than encourage suspicion of, offers of payment to research participants.

  18. Silicone granuloma from ruptured breast implants as a cause of cervical lymphadenopathy

    PubMed Central

    Gallagher, G; Skelly, BL

    2016-01-01

    A 56-year-old woman with a 10-year history of bilateral silicone breast implants presented to the ear, nose and throat outpatient clinic with a 2-month history of a right-sided neck lump. She was found to have a 1.3cm supraclavicular lymph node that gave the clinical impression of being reactive. Ultrasonography guided fine needle aspiration was inconclusive and initial review of subsequent computed tomography failed to identify a cause. This was followed by excisional biopsy of the lymph node, which revealed a silicone granuloma that was linked to a ruptured right-sided breast implant placed ten years previously. This case highlights the importance for otolaryngologists to consider silicone granuloma among the differential diagnoses of cervical lymphadenopathy in patients with a history of silicone breast implants. Recognising this differential diagnosis could avoid undue anxiety for patient and clinician regarding more serious pathology. PMID:27167311

  19. Investigation properties of superparamagnetic nanoparticles and magnetic field-dependent hyperthermia therapy

    NASA Astrophysics Data System (ADS)

    Hedayatnasab, Z.; Abnisa, F.; Daud, W. M. A. Wan

    2018-03-01

    The application of superparamagnetic nanoparticles as heating agents in hyperthermia therapy has made a therapeutic breakthrough in cancer treatment. The high efficiency of this magnetic hyperthermia therapy has derived from a great capability of superparamagnetic nanoparticles to generate focused heat in inaccessible tumors being effectively inactivated. The main challenges of this therapy are the improvement of the induction heating power of superparamagnetic nanoparticles and the control of the hyperthermia temperature in a secure range of 42 °C to 47 °C, at targeted area. The variation of these hyperthermia properties is principally dependent on the magnetic nanoparticles as well as the magnetic field leading to enhance the efficiency of magnetic hyperthermia therapy at targeted area and also avoid undue heating to healthy cells. The present study evaluates the magnetic hyperthermia therapy through the determination of superparamagnetic nanoparticles properties and magnetic field’ parameters.

  20. [Fitness, disability and mobbing].

    PubMed

    Magnavita, N; Bosco, M G; Ranalletta, D; Salerno, S

    2006-01-01

    Workers with handicap or psychological impairment are frequently submitted to mobbing. If causative factors of psychological disorders are not recognized, the physician charged of medical surveillance of workers may himself become a prosecutor and enhance the mobbing actions to the extent that the mobbed worker is discharged. In order to avoid this undue effect, the physician should strictly adhere to the body of legislation and to good occupational medicine practices. Health surveillance for occupationally exposed groups of workers is required under specific health and safety legislation. Workers unexposed to hazard in the workplace cannot be included in health surveillance programme, and declaring these workers unfit for their job is a patent violation of Workers' Statute Law. Psychological disorders should be carefully evaluated in order to clarify their relationship with work. The case of a worker affected with schizophrenia, already reported in the literature, is here re-analysed in order to emphasize these concepts.

  1. Breastfeeding information in pharmacology textbooks: a content analysis.

    PubMed

    Amir, Lisa H; Raval, Manjri; Hussainy, Safeera Y

    2013-07-01

    Women often need to take medicines while breastfeeding and pharmacists need to provide accurate information in order to avoid undue caution about the compatibility of medicines and breastfeeding. The objective of this study was to review information provided about breastfeeding in commonly used pharmacology textbooks. We asked 15 Australian universities teaching pharmacy courses to provide a list of recommended pharmacology textbooks in 2011. Ten universities responded, generating a list of 11 textbooks that we analysed for content relating to breastfeeding. Pharmacology textbooks outline the mechanisms of actions of medicines and their use: however, only a small emphasis is placed on the safety/compatibility of medicines for women during breastfeeding. Current pharmacology textbooks recommended by Australian universities have significant gaps in their coverage of medicine use in breastfeeding. Authors of textbooks should address this gap, so academic staff can recommend texts with the best lactation content.

  2. (De-) criminalization of attempted suicide in India: A review

    PubMed Central

    Ranjan, Rajeev; Kumar, Saurabh; Pattanayak, Raman Deep; Dhawan, Anju; Sagar, Rajesh

    2014-01-01

    Attempted suicide is a serious problem requiring mental health interventions, but it continues to be treated as a criminal offence under the section 309 of Indian Penal Code. The article reviews the international legal perspective across various regions of the world, discusses the unintended consequences of section 309 IPC and highlights the need for decriminalization of attempted suicide in India. The Mental Health Care Bill, 2013, still under consideration in the Rajya Sabha (upper house), has proposed that attempted suicide should not be criminally prosecuted. Decriminalization of suicidal attempt will serve to cut down the undue stigma and avoid punishment in the aftermath of incident, and lead to a more accurate collection of suicide-related statistics. From a policy perspective, it will further emphasize the urgent need to develop a framework to deliver mental health services to all those who attempt suicide. PMID:25535437

  3. Can procedural and substantive elements of decision-making be reconciled in assessments of mental capacity?

    PubMed Central

    Banner, Natalie F.

    2016-01-01

    Capacity legislation aims to protect individual autonomy and avoid undue paternalism as far as possible, partly through ensuring patients are not deemed to lack capacity because they make an unwise decision. To this end, the law employs a procedural test of capacity that excludes substantive judgments about patients’ decisions. However, clinical intuitions about patients’ capacity to make decisions about their treatment often conflict with a strict reading of the legal criteria for assessing capacity, particularly in psychiatry. In this article I argue that this tension arises because the procedural conception of capacity is inadequate and does not reflect the clinical or legal realities of assessing capacity. I propose that conceptualising capacity as having ‘recognisable reasons’ for a treatment decision provides a practical way of legitimately incorporating both procedural and substantive elements of decision-making into assessments of capacity. PMID:27891169

  4. Threat interferes with response inhibition.

    PubMed

    Hartikainen, Kaisa M; Siiskonen, Anna R; Ogawa, Keith H

    2012-05-09

    A potential threat, such as a spider, captures attention and engages executive functions to adjust ongoing behavior and avoid danger. We and many others have reported slowed responses to neutral targets in the context of emotional distractors. This behavioral slowing has been explained in the framework of attentional competition for limited resources with emotional stimuli prioritized. Alternatively, slowed performance could reflect the activation of avoidance/freezing-type motor behaviors associated with threat. Although the interaction of attention and emotion has been widely studied, little is known on the interaction between emotion and executive functions. We studied how threat-related stimuli (spiders) interact with executive performance and whether the interaction profile fits with a resource competition model or avoidance/freezing-type motor behaviors. Twenty-one young healthy individuals performed a Go-NoGo visual discrimination reaction time (RT) task engaging several executive functions with threat-related and emotionally neutral distractors. The threat-related distractors had no effect on the RT or the error rate in the Go trials. The NoGo error rate, reflecting failure in response inhibition, increased significantly because of threat-related distractors in contrast to neutral distractors, P less than 0.05. Thus, threat-related distractors temporarily impaired response inhibition. Threat-related distractors associated with increased commission errors and no effect on RT does not suggest engagement of avoidance/freezing-type motor behaviors. The results fit in the framework of the resource competition model. A potential threat calls for evaluation of affective significance as well as inhibition of undue emotional reactivity. We suggest that these functions tax executive resources and may render other executive functions, such as response inhibition, temporarily compromised when the demands for resources exceed availability.

  5. The Supreme Court, abortion, and the jurisprudence of class.

    PubMed Central

    Mariner, W K

    1992-01-01

    The US Supreme Court's decision in Planned Parenthood of Southeastern Pennsylvania v Casey both protects a woman's liberty to choose to terminate her pregnancy and permits the state to make it more difficult for her to exercise her choice. In their opinion on the case, Justices O'Connor, Kennedy, and Souter eloquently defend constitutional protection of the right to make intimate decisions like continuing or ending a pregnancy. At the same time, they permit the state to try to persuade pregnant women not to have abortions and to make abortion harder to obtain and more costly, as long as the state's methods do not create an "undue burden" on the decision. Any restriction on abortion is a burden; whether it is "undue" (and therefore unconstitutional) depends on one's circumstances. The Court appears to view the difference between an undue burden and mere inconvenience from the perspective of privilege. The restrictions that were upheld may not significantly affect middle-class access to abortion, but they could prove insurmountable for many less privileged women. PMID:1443311

  6. Does financial compensation for living kidney donation change willingness to donate?

    PubMed

    Gordon, E J; Patel, C H; Sohn, M-W; Hippen, B; Sherman, L A

    2015-01-01

    The potential use of financial compensation to increase living kidney donation rates remains controversial in potentially introducing undue inducement of vulnerable populations to donate. This cross-sectional study assessed amounts of financial compensation that would generate motivation and an undue inducement to donate to family/friends or strangers. Individuals leaving six Departments of Motor Vehicles were surveyed. Of the 210 participants who provided verbal consent (94% participation rate), respondents' willingness to donate would not change (70%), or would increase (29%) with compensation. Median lowest amounts of financial compensation for which participants would begin to consider donating a kidney were $5000 for family/friends, and $10,000 for strangers; respondents reporting $0 for family/friends (52%) or strangers (26%) were excluded from analysis. Median lowest amounts of financial compensation for which participants could no longer decline (perceive an undue inducement) were $50,000 for family/friends, and $100,000 for strangers; respondents reporting $0 for family/friends (44%) or strangers (23%) were excluded from analysis. The two most preferred forms of compensation included: direct payment of money (61%) and paid leave (21%). The two most preferred uses of compensation included: paying off debt (38%) and paying nonmedical expenses associated with the transplant (29%). Findings suggest tolerance for, but little practical impact of, financial compensation. Certain compensation amounts could motivate the public to donate without being perceived as an undue inducement. © Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.

  7. Deathbed wills: assessing testamentary capacity in the dying patient.

    PubMed

    Peisah, C; Luxenberg, J; Liptzin, B; Wand, A P; Shulman, K; Finkel, S

    2014-02-01

    Deathbed wills by their nature are susceptible to challenge. Clinicians are frequently invited to give expert opinion about a dying testator's testamentary capacity and/or vulnerability to undue influence either contemporaneously, when the will is made, or retrospectively upon a subsequent challenge, yet there is minimal discourse in this area to assist practice. The IPA Capacity Taskforce explored the issue of deathbed wills to provide clinicians with an approach to the assessment of testamentary capacity at the end of life. A systematic review searching PubMed and Medline using the terms: "deathbed and wills," "deathbed and testamentary capacity," and "dying and testamentary capacity" yielded one English-language paper. A search of the individual terms "testamentary capacity" and "deathbed" yielded one additional relevant paper. A focused selective review was conducted using these papers and related terms such as "delirium and palliative care." We present two cases to illustrate the key issues here. Dying testators are vulnerable to delirium and other physical and psychological comorbidities. Delirium, highly prevalent amongst terminal patients and manifesting as either a hyperactive or hypoactive state, is commonly missed and poorly documented. Whether the person has testamentary capacity depends on whether they satisfy the Banks v Goodfellow legal criteria and whether they are free from undue influence. Regardless of the clinical diagnosis, the ultimate question is can the testator execute a specific will with due consideration to its complexity and the person's circumstances? Dual ethical principles of promoting autonomy of older people with mental disorders whilst protecting them against abuse and exploitation are at stake here. To date, there has been scant discourse in the scientific literature regarding this issue.

  8. Conflict of Interest Policies at French Medical Schools: Starting from the Bottom.

    PubMed

    Scheffer, Paul; Guy-Coichard, Christian; Outh-Gauer, David; Calet-Froissart, Zoéline; Boursier, Mathilde; Mintzes, Barbara; Borde, Jean-Sébastien

    2017-01-01

    Medical faculties have a role in ensuring that their students are protected from undue commercial influence during their training, and are educated about professional-industry interactions. In North America, many medical faculties have introduced more stringent conflict of interest (COI) policies during the last decade. We asked whether similar steps had been taken in France. We hypothesized that such policies may have been introduced following a 2009-2010 drug safety scandal (benfluorex, Mediator) in which COIs in medicine received prominent press attention. We searched the websites of all 37 French Faculties of Medicine in May 2015 for COI policies and curriculum, using standardized keyword searches. We also surveyed all deans of medicine on institutional COI policies and curriculum, based on criteria developed in similar US and Canadian surveys. Personal contacts were also consulted. We calculated a summary score per faculty based on 13 criteria. [range 0-26; higher scores denoting stronger policies]. In total, we found that 9/37 (24%) of French medical schools had either introduced related curriculum or implemented a COI-related policy. Of these, only 1 (2.5%) had restrictive policies for any category. No official COI policies were found at any of the schools. However, at 2 (5%), informal policies were reported. The maximum score per faculty was 5/26, with 28 (76%) scoring 0. This is the first survey in France to examine COI policies at medical faculties. We found little evidence that protection of medical students from undue commercial influence is a priority, either through institutional policies or education. This is despite national transparency legislation on industry financing of health professionals and limits on gifts. The French National Medical Students Association (ANEMF) has called for more attention to COI in medical education; our results strongly support such a call.

  9. Paying Research Participants: Regulatory Uncertainty, Conceptual Confusion, and a Path Forward

    PubMed Central

    Largent, Emily A; Lynch, Holly Fernandez

    2017-01-01

    The practice of offering payment to individuals in exchange for their participation in clinical research is widespread and longstanding. Nevertheless, such payment remains the source of substantial debate, in particular about whether or the extent to which offers of payment coerce and/or unduly induce individuals to participate. Yet, the various laws, regulations, and ethical guidelines that govern the conduct of human subjects research offer relatively little in the way of specific guidance regarding what makes a payment offer ethically acceptable—or not. Moreover, there is a lack of definitional agreement regarding what the terms coercion and undue inducement mean in the human subjects research context. It is, therefore, unsurprising that investigators and Institutional Review Boards (IRBs) experience confusion about how to evaluate offers of payment, and lean toward conservative approaches. These trends are exemplified by our pilot data regarding the ways in which some IRB members and investigators (mis)understand the concepts of coercion and undue inducement, as well as the ways in which certain research institutions oversee offers of payment at a local level. This article systematically examines the legal and ethical dimensions of offering payment to research participants. It argues that many concerns about offers of payment to research participants can be attributed to the misguided view that such offers ought to be treated differently than offers of payment in other contexts, a form of “research exceptionalism.” We show that rejection of research exceptionalism with respect to payment helps settle open debates about both how best to define coercion and undue influence, and how to understand the relation between these concepts and offers of payment. We argue for adoption of our preferred definitions, ideally by regulatory authorities, and against the conventional conservatism toward payment of research participants. Instead, we draw attention to the rarely asked, even radical, question: are research participants paid enough? We conclude by arguing that we ought to change the default to favor, rather than encourage suspicion of, offers of payment to research participants. PMID:29249912

  10. Intranasal bacille Calmette–Guérin (BCG) vaccine dosage needs balancing between protection and lung pathology

    PubMed Central

    TREE, J A; WILLIAMS, A; CLARK, S; HALL, G; MARSH, P D; IVANYI, J

    2004-01-01

    Intranasal vaccination may offer practical benefits and better protection against respiratory infections, including tuberculosis. In this paper, we investigated the persistence of the Mycobacterium bovis-strain bacille Calmette–Guérin (BCG) Pasteur, lung granuloma formation and protection against pathogenic tuberculous challenge in mice. A pronounced BCG dose-dependent granulomatous infiltration of the lungs was observed following intranasal, but not after subcutaneous, vaccination. Corresponding doses of BCG, over a 100-fold range, imparted similar protection against H37Rv challenge when comparing the intranasal and subcutaneous vaccination routes. Interestingly, a BCG dose-dependent reduction of the H37Rv challenge infection was observed in the lungs, but not in the spleens, following both intranasal and subcutaneous vaccination. In the light of the observed concurrence between the extent of granuloma formation and the level of protection of the lungs, we conclude that intranasal vaccination leading to best protective efficacy needs to be balanced with an acceptable safety margin avoiding undue pathology in the lungs. PMID:15544615

  11. Evaluation of a rapid immunodiagnostic test kit for rabies virus.

    PubMed

    Kang, BoKyu; Oh, JinSik; Lee, ChulSeung; Park, Bong-Kyun; Park, YoungNam; Hong, KyungSoo; Lee, KyungGi; Cho, ByungKi; Song, DaeSub

    2007-10-01

    A rapid immunodiagnostic test kit for rabies virus detection was evaluated using 51 clinical samples and 4 isolates of rabies virus. The quick detection of rabies virus under field conditions may be helpful in determining if post-exposure prophylaxis is needed, thereby avoiding unnecessary treatments, as well as undue economic burden. There are several widely used diagnostic methods for rabies, including fluorescent antibody tests, reverse transcription polymerase chain reaction, and electron microscopy; however, these methods include time-consuming, intricate, and costly procedures. The rapid immunodiagnostic test was able to detect rabies virus in clinical samples, including brain tissue and saliva, in addition to 10(3.2) 50% lethal dose (LD(50))/mL cell-adapted rabies virus. The assay was not cross-reactive with non-rabies virus microbes. When the performance of the rapid immunodiagnostic test was compared to a fluorescent antibody test, the rapid immunodiagnostic test had a sensitivity of 91.7% and specificity of 100% (95.8% CI).

  12. Self-inflicted long complex urethro-vesical foreign body: is open surgery always needed?

    PubMed Central

    Garg, Manish; Kumar, Manoj; Sankhwar, Satyanarayan; Singh, Vishwajeet

    2013-01-01

    In this case report, we describe our experience of a self-inflicted long complex urethrovesical foreign body managed suprapubically through the minimally invasive technique. A 21-year-old man with antipsychotic treatment for the past 10 years presented with a long electric cable wire in his bladder with the distal end in the penile urethra. He presented with symptoms of voiding difficulty and gross haematuria. An attempt of gentle retrieval of wire through the cystoscopic forceps was not successful due to a very complex knot of cable in the bladder. To avoid open surgery such as suprapubic cystotomy, the percutaneous minimally invasive approach was planned. Access to the bladder was achieved by the suprapubic puncture of the bladder, placement of a guide-wire and serial dilation of supra-pubic tract. With the help of nephroscope, through suprapubic tract, the cable wire was retrieved antegradely without causing undue trauma to the bladder or urethra. PMID:23749820

  13. Contrasting Views of Risk Perception and Influence of Financial Compensation Between Adolescent Research Participants and Their Parents

    PubMed Central

    Wiener, Lori; Viola, Adrienne; Wilfond, Benjamin S.; Wendler, David; Grady, Christine

    2017-01-01

    U.S. regulations governing pediatric research do not specify the assent process. To identify best practices, it is important to examine parents’ and adolescents’ views. The present study focuses on parents’ and adolescents’ views regarding possible research risks and the influence of financial compensation on their willingness to accept research procedures. Interviews were conducted with 177 adolescents participating in clinical research for a medical or psychiatric illness, or as healthy volunteers, and a parent. Significant discordance was found between how bothered the teen would feel from research-related side effects and procedures compared with parental report. Most teens were willing to accept non-beneficial procedures without compensation. Payment had significantly greater influence on healthy volunteers and their parents compared with those with a medical or psychiatric illness. Discordance between adolescent and parental views about risks recommends obtaining direct input from adolescents during the assent process. Modest payments should not raise concerns of undue inducement, especially in teens with pre-existing conditions. PMID:25742666

  14. [International regulation of ethics committees on biomedical research as protection mechanisms for people: analysis of the Additional Protocol to the Convention on Human Rights and Biomedicine, concerning Biomedical Research of the Council of Europe].

    PubMed

    de Lecuona, Itziar

    2013-01-01

    The article explores and analyses the content of the Council of Europe's Additional Protocol to the Convention on Human Rights and Biomedicine concerning Biomedical Research regarding the standard legal instrument in biomedical research, issued by an international organization with leadership in bioethics. This implies ethics committees are mechanisms of protection of humans in biomedical research and not mere bureaucratic agencies and that a sound inescapable international regulatory framework exists for States to regulate biomedical research. The methodology used focuses on the analysis of the background, the context in which it is made and the nature and scope of the Protocol. It also identifies and analyses the characteristics and functions of ethics committees in biomedical research and, in particular, the information that should be provided to this bodies to develop their functions previously, during and at the end of research projects. This analysis will provide guidelines, suggestions and conclusions for the awareness and training of members of these committees in order to influence the daily practice. This paper may also be of interest to legal practitioners who work in different areas of biomedical research. From this practical perspective, the article examines the legal treatment of the Protocol to meet new challenges and classic issues in research: the treatment of human biological samples, the use of placebos, avoiding double standards, human vulnerability, undue influence and conflicts of interest, among others. Also, from a critical view, this work links the legal responses to develop work procedures that are required for an effective performance of the functions assigned of ethics committees in biomedical research. An existing international legal response that lacks doctrinal standards and provides little support should, however, serve as a guide and standard to develop actions that allow ethics committees -as key bodies for States- to advance in the protection of humans in biomedical research.

  15. Artificial milk-feeding women׳s views of their feeding choice in Ireland.

    PubMed

    Carroll, Margaret; Gallagher, Louise; Clarke, Mike; Millar, Sally; Begley, Cecily

    2015-06-01

    despite the well-documented benefits of breast feeding to both mother and child, breast-feeding initiation rates in Ireland are the second lowest in Europe. This study set out to explore the views of women from low socio-economic groups in Ireland on their choice to feed their infants artificial milk, and to elicit factors that may encourage these women to breast feed in the future. a qualitative descriptive approach was used. data were collected through recorded focus groups and individual interviews, using a semi-structured interview schedule. Data were transcribed verbatim. interviews took place in two regions in the Republic of Ireland, north and south. a purposive sample was drawn from the population of 2572 women taking part in the Irish Infant Feeding Study who had never breast fed previously, had intended to, and had, fed this infant artificial milk and who had completed their education before they were 18 years of age. Two focus groups with two women in each were conducted and six women took part in individual interviews. constant comparative analysis was performed to construct the categories and concepts that led to the final themes. these artificial milk-feeding women based their infant feeding decision on many social and experiential factors. The major influences on their decisions were: personal attitudes toward feeding methods, and external influences on infant feeding methods. Attitudes towards other women and feeding future infants reinforced a strong preference towards artificial milk feeding. it is apparent that a prevailing culture that is unreceptive to breast feeding and the lack of positive breast-feeding role models, contributed to a strong commitment to artificial milk feeding for these participants. Promotion of breast feeding must take account of the complex contexts in which women make decisions. Advice regarding breast feeding should take account of women׳s feelings and avoid undue pressure, while still promoting the benefits of breast feeding to women and their families. Copyright © 2015 Elsevier Ltd. All rights reserved.

  16. Influence of multiple ion species on low-frequency electromagnetic wave instabilities. [in solar wind

    NASA Technical Reports Server (NTRS)

    Brinca, Armando L.; Tsurutani, Bruce T.

    1989-01-01

    The effect of multiple (singly ionized) coexisting newborn ion species on the stability of low-frequency electromagnetic waves was investigated using a plasma model in which solar wind magnetoplasma is made up of isotropic Maxwellian electron and proton populations with a common number density of 4.95/cu cm and temperatures equal to 17.2 eV and 6.9 eV, respectively. It is shown that the effect of multiple ions on wave growth, for given background magnetoplasma conditions and relative densities, depends not only on their mass but also on the physical nature of the wave modes. If the ion masses are disparate, each one of the coexisting ion beams tends to stimulate instabilities without undue influence from the other species. If the masses of newborn ions are similar, they can strongly catalyze wave growth of fluidlike nonresonant modes, but bring about weak growth enhancements in cyclotron resonant instabilities.

  17. Public perception of cross-infection control in dentistry.

    PubMed

    Thomson, W M; Stewart, J F; Carter, K D; Spencer, A J

    1997-10-01

    Since the advent of HIV/AIDS at the beginning of the 1980s, concern has generated considerable impetus for change in cross-infection control procedures in dentistry. This process has been hastened partly by media coverage which, in tending to favour sensation over rational discourse, has played a not inconsiderable role in shaping public understanding and expectations. This study aimed to investigate public perceptions of cross-infection control in dentistry in Australia using a postal follow-up to the 1995 National Dental Telephone Interview Survey. The postal survey response rate was 85.2 per cent. Concerns about the procedures used by their dentist to sterilize instruments were reported by 13.3 per cent of respondents overall, and this was greater among non-health-card-holders, individuals who mainly spoke a language other than English in the home, and those who reported a non-routine dental visiting pattern. Avoidance or delaying of dental visits due to the perceived cross-infection risk was reported by an overall 3.6 per cent of people, and this was higher among females and those who expressed concern about cross-infection control. The profession has a responsibility to ensure that information on the measures which have been taken to reduce the risk of cross-infection in dentistry is disseminated as widely and as clearly as possible so that undue public concern and avoidance of dental care are minimized.

  18. Kamakahi vs ASRM and the future of compensation for human eggs.

    PubMed

    Klitzman, Robert L; Sauer, Mark V

    2015-08-01

    A recent lawsuit that alleges that the American Society for Reproductive Medicine (ASRM) engages in price-fixing by capping the amount of compensation paid for human oocytes has several critical ethical and policy implications that have received relatively little attention. ASRM has argued that ceilings on donor compensation prevent enticement, exploitation, and oocyte commodification. Critics counter that low donor compensation decreases supply, because fewer women are then interested in donating, which then increases prices for the service that physicians, not donors, accrue, and that ethical goals can be better achieved through enhanced informed consent, hiring egg donor advocates, and better counseling and screening. Yet, if compensation caps are removed, questions emerge concerning what the oocyte market would then look like. Informed consent is an imperfect process. Beyond the legal and economic questions of whether ASRM violates the Sherman Anti-trust Act also lie crucial questions of whether human eggs should be viewed as other products. We argue that human eggs differ from other factory-produced goods and should command moral respect. Although eggs (or embryos) are not equivalent to human beings, they deserve special consideration, because of their potential for human life, and thus have a different moral status. ASRM's current guidelines appear to address, even if imperfectly, ethical challenges that are related to egg procurement for infertility treatment. Given public concerns about oocyte commodification and ASRM's wariness of government regulations, existing guidelines may represent a compromise by aiding patients who seek eggs, while simultaneously trying to avoid undue influence, exploitation, and eugenics. Although the ultimate outcome of this lawsuit remains unclear, policy makers, providers, lawyers, judges, and others should attend seriously to these issues. Alternatives to current ASRM guidelines may be possible (eg, raising the current caps to, say, $12,000 or $15,000, potentially increasing donation, while still avoiding certain ethical difficulties) and warrant close consideration. These complex conflicting ethical issues deserve more attention than they have received because they affect key aspects of clinical practice and the lives of countless patients. Copyright © 2015. Published by Elsevier Inc.

  19. Kamakahi vs ASRM and the future of compensation for human eggs

    PubMed Central

    Klitzman, Robert L.; Sauer, Mark V.

    2015-01-01

    A recent lawsuit that alleges that the American Society for Reproductive Medicine (ASRM) engages in price-fixing by capping the amount of compensation paid for human oocytes has several critical ethical and policy implications that have received relatively little attention. ASRM has argued that ceilings on donor compensation prevent enticement, exploitation, and oocyte commodification. Critics counter that low donor compensation decreases supply, because fewer women are then interested in donating, which then increases prices for the service that physicians, not donors, accrue, and that ethical goals can be better achieved through enhanced informed consent, hiring egg donor advocates, and better counseling and screening. Yet, if compensation caps are removed, questions emerge concerning what the oocyte market would then look like. Informed consent is an imperfect process. Beyond the legal and economic questions of whether ASRM violates the Sherman Anti-trust Act also lie crucial questions of whether human eggs should be viewed as other products. We argue that human eggs differ from other factory-produced goods and should command moral respect. Although eggs (or embryos) are not equivalent to human beings, they deserve special consideration, because of their potential for human life, and thus have a different moral status. ASRM’s current guidelines appear to address, even if imperfectly, ethical challenges that are related to egg procurement for infertility treatment. Given public concerns about oocyte commodification and ASRM’s wariness of government regulations, existing guidelines may represent a compromise by aiding patients who seek eggs, while simultaneously trying to avoid undue influence, exploitation, and eugenics. Although the ultimate outcome of this lawsuit remains unclear, policy makers, providers, lawyers, judges, and others should attend seriously to these issues. Alternatives to current ASRM guidelines may be possible (eg, raising the current caps to, say, $12,000 or $15,000, potentially increasing donation, while still avoiding certain ethical difficulties) and warrant close consideration. These complex conflicting ethical issues deserve more attention than they have received because they affect key aspects of clinical practice and the lives of countless patients. PMID:25816784

  20. Conflict of Interest Policies at French Medical Schools: Starting from the Bottom

    PubMed Central

    Scheffer, Paul; Guy-Coichard, Christian; Outh-Gauer, David; Calet-Froissart, Zoéline; Boursier, Mathilde; Mintzes, Barbara; Borde, Jean-Sébastien

    2017-01-01

    Background Medical faculties have a role in ensuring that their students are protected from undue commercial influence during their training, and are educated about professional-industry interactions. In North America, many medical faculties have introduced more stringent conflict of interest (COI) policies during the last decade. We asked whether similar steps had been taken in France. We hypothesized that such policies may have been introduced following a 2009–2010 drug safety scandal (benfluorex, Mediator) in which COIs in medicine received prominent press attention. Methods We searched the websites of all 37 French Faculties of Medicine in May 2015 for COI policies and curriculum, using standardized keyword searches. We also surveyed all deans of medicine on institutional COI policies and curriculum, based on criteria developed in similar US and Canadian surveys. Personal contacts were also consulted. We calculated a summary score per faculty based on 13 criteria. [range 0–26; higher scores denoting stronger policies] Results In total, we found that 9/37 (24%) of French medical schools had either introduced related curriculum or implemented a COI-related policy. Of these, only 1 (2.5%) had restrictive policies for any category. No official COI policies were found at any of the schools. However, at 2 (5%), informal policies were reported. The maximum score per faculty was 5/26, with 28 (76%) scoring 0. Conclusion This is the first survey in France to examine COI policies at medical faculties. We found little evidence that protection of medical students from undue commercial influence is a priority, either through institutional policies or education. This is despite national transparency legislation on industry financing of health professionals and limits on gifts. The French National Medical Students Association (ANEMF) has called for more attention to COI in medical education; our results strongly support such a call. PMID:28068362

  1. Gillick reinstated: judging mid-childhood competence in healthcare law: an NHS Trust v ABC & A Local Authority [2014] EWHC 1445 (Fam).

    PubMed

    Moreton, Kirsty L

    2015-01-01

    This case commentary discusses a recent case concerning the competence of a 13-year-old girl to consent to the termination of her pregnancy. It critically analyses four specific elements of the judgment--Gillick competence, the impact of best interests, judicial deference to medical opinion, and individualism and the construction of undue influence. It concludes by commending the approach taken by the court as a reinstatement of the law as originally intended in Gillick but is nonetheless cautious as to its likely overall effect upon child decision-making. © The Author [2014]. Published by Oxford University Press; all rights reserved. For Permissions, please email: journals.permissions@oup.com.

  2. Teamwork, Communication, Formula-One Racing and the Outcomes of Cardiac Surgery

    PubMed Central

    Merry, Alan F.; Weller, Jennifer; Mitchell, Simon J.

    2014-01-01

    Abstract: Most cardiac units achieve excellent results today, but the risk of cardiac surgery is still relatively high, and avoidable harm is common. The story of the Green Lane Cardiothoracic Unit provides an exemplar of excellence, but also illustrates the challenges associated with changes over time and with increases in the size of a unit and the complexity of practice today. The ultimate aim of cardiac surgery should be the best outcomes for (often very sick) patients rather than an undue focus on the prevention of error or adverse events. Measurement is fundamental to improving quality in health care, and the framework of structure, process, and outcome is helpful in considering how best to achieve this. A combination of outcomes (including some indicators of important morbidity) with key measures of process is advocated. There is substantial evidence that failures in teamwork and communication contribute to inefficiency and avoidable harm in cardiac surgery. Minor events are as important as major ones. Six approaches to improving teamwork (and hence outcomes) in cardiac surgery are suggested. These are: 1) subspecialize and replace tribes with teams; 2) sort out the leadership while flattening the gradients of authority; 3) introduce explicit training in effective communication; 4) use checklists, briefings, and debriefings and engage in the process; 5) promote a culture of respect alongside a commitment to excellence and a focus on patients; 6) focus on the performance of the team, not on individuals. PMID:24779113

  3. Teamwork, communication, formula-one racing and the outcomes of cardiac surgery.

    PubMed

    Merry, Alan F; Weller, Jennifer; Mitchell, Simon J

    2014-03-01

    Most cardiac units achieve excellent results today, but the risk of cardiac surgery is still relatively high, and avoidable harm is common. The story of the Green Lane Cardiothoracic Unit provides an exemplar of excellence, but also illustrates the challenges associated with changes over time and with increases in the size of a unit and the complexity of practice today. The ultimate aim of cardiac surgery should be the best outcomes for (often very sick) patients rather than an undue focus on the prevention of error or adverse events. Measurement is fundamental to improving quality in health care, and the framework of structure, process, and outcome is helpful in considering how best to achieve this. A combination of outcomes (including some indicators of important morbidity) with key measures of process is advocated. There is substantial evidence that failures in teamwork and communication contribute to inefficiency and avoidable harm in cardiac surgery. Minor events are as important as major ones. Six approaches to improving teamwork (and hence outcomes) in cardiac surgery are suggested. These are: 1) subspecialize and replace tribes with teams; 2) sort out the leadership while flattening the gradients of authority; 3) introduce explicit training in effective communication; 4) use checklists, briefings, and debriefings and engage in the process; 5) promote a culture of respect alongside a commitment to excellence and a focus on patients; 6) focus on the performance of the team, not on individuals.

  4. Mandatory evacuation of residents during the Fukushima nuclear disaster: an ethical analysis.

    PubMed

    Akabayashi, Akira; Hayashi, Yoshinori

    2012-08-01

    The Japan earthquake and tsunami of 11 March 2011 severely damaged the Fukushima Daiichi nuclear plant. After learning of the radiation leak, the Japanese government issued an evacuation directive for residents within 20 km of the plant a day after the earthquake. Approximately 1 month later, this area was designated a 'high alert zone' and effectively sealed-off. The purpose of this report is to examine these measures from an ethical perspective, and consider what lessons can be drawn from this experience. Analytic discussion. We examine the measures from an ethical perspective and argue that if the government's aim was to avoid health risks posed by radiation exposure, then ordering compulsory expulsion of all residents cannot be ethically justified. We assert that the government may not have ordered the mandatory evacuation solely based on health risks, but rather to maintain public order. Careful scrutiny of the case revealed that this public health intervention involved an objective completely unrelated to public health, and that disguising these policies using the reasonable and acceptable purpose of public health made it easier to justify undue restriction of individual liberty.

  5. The stem cell debate continues: the buying and selling of eggs for research.

    PubMed

    Baylis, F; McLeod, C

    2007-12-01

    Now that stem cell scientists are clamouring for human eggs for cloning-based stem cell research, there is vigorous debate about the ethics of paying women for their eggs. Generally speaking, some claim that women should be paid a fair wage for their reproductive labour or tissues, while others argue against the further commodification of reproductive labour or tissues and worry about voluntariness among potential egg providers. Siding mainly with those who believe that women should be financially compensated for providing eggs for research, the new stem cell guidelines of the International Society for Stem Cell Research (ISSCR) legitimise both reimbursement of direct expenses and financial compensation for many women who supply eggs for research. In this paper, the authors do not attempt to resolve the thorny issue of whether payment for eggs used in human embryonic stem cell research is ethically legitimate. Rather, they want to show specifically that the ISSCR recommended payment practices are deeply flawed and, more generally, that all payment schemes that aim to avoid undue inducement of women risk the global exploitation of economically disadvantaged women.

  6. How Should We Intervene on the Financial Toxicity of Cancer Care? One Shot, Four Perspectives.

    PubMed

    Zafar, S Yousuf; Newcomer, Lee N; McCarthy, Justin; Fuld Nasso, Shelley; Saltz, Leonard B

    2017-01-01

    The median price of a month of chemotherapy has increased by an order of magnitude during the past 20 years, far exceeding inflation over the same period. Along with rising prices, increases in cost sharing have forced patients to directly shoulder a greater portion of those costs, resulting in undue financial burden and, in some cases, cost-related nonadherence to treatment. What can we do to intervene on treatment-related financial toxicity of patients? No one party can single-handedly solve the problem, and the solution must be multifaceted and creative. A productive discussion of the problem must avoid casting blame and, instead, must look inward for concrete starting points toward improvement in the affordability and value of cancer care. With these points in mind, the authors-representatives from the pharmaceutical industry, insurance providers, oncologists, and patient advocacy-have each been asked to respond with a practical answer to the provocative hypothetical question, "If you could propose one thing, and one thing only, in terms of an action or change by the constituency you represent in this discussion, what would that be?"

  7. Eating Disorders

    MedlinePlus

    ... also points a contributing genetic and biological factors. Environment. Cultural pressures that stress “thinness” as beautiful for women and muscular development and body size for men places undue pressure ...

  8. Public health, science, and policy debate: being right is not enough.

    PubMed

    Camargo, Kenneth; Grant, Roy

    2015-02-01

    Public health is usually enacted through public policies, necessitating that the public engage in debates that, ideally, are grounded in solid scientific findings. Mistrust in science, however, has compromised the possibility of deriving sound policy from such debates, partially owing to justified concerns regarding undue interference and even outright manipulation by commercial interests. This situation has generated problematic impasses, one of which is the emergence of an anti-vaccination movement that is already affecting public health, with a resurgence in the United States of preventable diseases thought to have been eradicated. Drawing on British sociologist Harry Collins' work on expertise, we propose a theoretical framework in which the paralyzing, undue public distrust of science can be analyzed and, it is hoped, overcome.

  9. Factors in Client–Clinician Interaction That Influence Hearing Aid Adoption

    PubMed Central

    Jennings, Mary Beth; Shaw, Lynn; Meston, Christine N.; Cheesman, Margaret F.

    2011-01-01

    The influence of client–clinician interactions has not been emphasized in hearing health care, despite the extensive evidence of the impact of the provider–patient interaction on health outcomes. The purpose of this study was to identify factors in the client–clinician interaction that may influence hearing aid adoption. Thirteen adults who had received a hearing aid recommendation within the previous 3 months and 10 audiologists participated in a study to generate, sort, and rate the importance of factors in client–clinician interaction that may influence the hearing aid purchase decision. A concept mapping approach was used to define meaningful clusters of factors. Quantitative analysis and qualitative interpretation of the statements resulted in eight concepts. The concepts in order of their importance are (a) Ensuring client comfort, (b) Understanding and meeting client needs, (c) Client-centered traits and actions, (d) Acknowledging client as an individual, (e) Imposing undue pressure and discomfort, (f) Conveying device information by clinician, (g) Supporting choices and shared decision making, and (h) Factors in client readiness. Two overarching themes of client-centered interaction and client empowerment were identified. Results highlight the influence of the client–clinician interaction in hearing aid adoption and suggest the possibility of improving hearing aid adoption by empowering clients through a client-centered interaction. PMID:22155784

  10. 48 CFR 927.402-2 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... directed toward achieving the following objectives: (a) Making the benefits of the energy research...; and (d) Fostering competition and preventing undue market concentration or the creation or maintenance...

  11. 48 CFR 927.402-2 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... directed toward achieving the following objectives: (a) Making the benefits of the energy research...; and (d) Fostering competition and preventing undue market concentration or the creation or maintenance...

  12. 48 CFR 927.402-2 - Policy.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... directed toward achieving the following objectives: (a) Making the benefits of the energy research...; and (d) Fostering competition and preventing undue market concentration or the creation or maintenance...

  13. 48 CFR 927.402-2 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... directed toward achieving the following objectives: (a) Making the benefits of the energy research...; and (d) Fostering competition and preventing undue market concentration or the creation or maintenance...

  14. 48 CFR 927.402-2 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... directed toward achieving the following objectives: (a) Making the benefits of the energy research...; and (d) Fostering competition and preventing undue market concentration or the creation or maintenance...

  15. Key Stakeholders' Perceptions of Motivators for Research Participation Among Individuals Who Are Incarcerated.

    PubMed

    Hanson, Bridget L; Faulkner, Sherilyn A; Brems, Christiane; Corey, Staci L; Eldridge, Gloria D; Johnson, Mark E

    2015-10-01

    Understanding motivations of research participants is crucial for developing ethical research protocols, especially for research with vulnerable populations. Through interviews with 92 institutional review board members, prison administrators, research ethicists, and researchers, we explored key stakeholders' perceptions of what motivates incarcerated individuals to participate in research. Primary motivators identified were a desire to contribute to society, gaining knowledge and health care, acquiring incentives, and obtaining social support. The potential for undue influence or coercion were also identified as motivators. These results highlight the need for careful analysis of what motivates incarcerated individuals to participate in research as part of developing or reviewing ethically permissible and responsible research protocols. Future research should expand this line of inquiry to directly include perspectives of incarcerated individuals. © The Author(s) 2015.

  16. Unhealthy marketing of pharmaceutical products: An international public health concern.

    PubMed

    Mulinari, Shai

    2016-05-01

    I consider the current state of pharmaceutical marketing vis-à-vis ethical and legal standards and advocate measures to improve it. There is abundant evidence of unethical or illicit marketing. It fuels growing concerns about undue corporate influence over pharmaceutical research, education, and consumption. The most extensive evidence of industry transgressions comes from the United States (US), where whistle-blowers are encouraged by financial rewards to help uncover illicit marketing and fraud. Outside the US increasing evidence of transgressions exists. Recently I have observed a range of new measures to align pharmaceutical marketing practices with ethical and legal standards. In the interest of public health, I highlight the need for additional and more profound reforms to ensure that information about medicines supports quality and resource-efficient care.

  17. 10 CFR 63.142 - Quality assurance criteria.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... sequences or that are important to waste isolation capabilities that could cause undue risk to the health...: criticality physics, stress, thermal, hydraulic, and preclosure and postclosure analyses; compatibility of...

  18. 9 CFR 381.132 - Labeling approval.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...; (iii) Denial of the request would create undue economic hardship; and (iv) An unfair competitive advantage would not result from the granting of the temporary approval. (2) Extensions of temporary...

  19. 43 CFR 8341.1 - Regulations governing use.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... to cause significant, undue damage to or disturbance of the soil, wildlife, wildlife habitat, improvements, cultural, or vegetative resources or other authorized uses of the public lands; and (5) During...

  20. 49 CFR 177.834 - General requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... as to prohibit the fueling of machinery or vehicles used in road construction or maintenance. (i... transit; fueling road units. Reasonable care should be taken to prevent undue rise in temperature of...

  1. 49 CFR 178.516 - Standards for fiberboard boxes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... bending qualities. Fiberboard must be cut, creased without cutting through any thickness of fiberboard, and slotted so as to permit assembly without cracking, surface breaks, or undue bending. The fluting...

  2. 18 CFR 380.15 - Siting and maintenance requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... disposed of without undue delay. (7) Remaining trees and shrubs should not be unnecessarily damaged. (8... nearby residences or public areas, should be planted in trees and shrubs, or other appropriate...

  3. Ethics in exercise science research.

    PubMed

    Shephard, Roy J

    2002-01-01

    Ethical evaluation is a vital but sometimes neglected component of research policy in the exercise sciences. This article reviews some issues in human research, with particular reference to studies undertaken by the exercise scientist. The typical composition and functions of the research review committee are examined in the context of individual and institutional ethical norms. In multicentre trials, there are often problems in coordinating ethical approval between institutions. On-going monitoring of research may have value in the detection of fraud. A reduction in the secrecy of committee proceedings would allow a closer auditing of the research review process. Authors need to give more thought to developing appropriate research questions. Scarce resources may be wasted because of inappropriate study design or an inadequate statistical analysis of the results. The costs of any proposed investigation must be weighed carefully against possible benefits. Confidentiality is particularly important when collecting data at the worksite or over the internet. Informed consent should be based on a full disclosure of risks; the participant should be competent to understand the nature and magnitude of these risks, and undue pressure to participate in an experiment must be avoided. The opposition to placebo trials expressed in the Declaration of Helsinki requires careful consideration of the use of control groups, since regular exercise is known to benefit health. If research is conducted in under-developed societies, the standards of treatment of the participants should match those expected in developed societies. The publication of findings must be fair and well balanced; examples of fraud and misconduct continue to be reported. Some journals apparently still publish papers, even if they have not received an initial institutional review. Editors should restore meaning to the word 'author', avoid the bias to a publication of 'positive' results, limit the impact of commercial sponsorship on reporting and curtail the current trend to redundant presentations and publications. Development of academic courses in research ethics may help to avoid some of these abuses.

  4. Implementation of Telemedicine Consultation to Assess Unplanned Transfers in Rural Long-Term Care Facilities, 2012-2015: A Pilot Study.

    PubMed

    Hofmeyer, Joshua; Leider, Jonathon P; Satorius, Jennifer; Tanenbaum, Erin; Basel, David; Knudson, Alana

    2016-11-01

    Public and private entities in the United States spend billions of dollars each year on potentially avoidable hospitalizations. This is a common occurrence in long-term care (LTC) facilities, especially in rural jurisdictions. This article details the creation of a telemedicine approach to assess residents from rural LTC facilities for potential transfer to hospitals. An electronic LTC (eLTC) pilot was conducted in 20 pilot LTC facilities from 2012-2015. Each site underwent technologic assessment and upgrading to ensure that 2-way video communication was possible. A new central "hub" was staffed with advanced practice providers and registered nurses. Long-term care pilot sites were trained and rolled out over 3 years. This article reports development and implementation of the pilot, as well as descriptive statistics associated with provider assessments and averted transfers. Over 3 years, 736 eLTC consultations occurred in pilot sites. One-quarter of consultations occurred between 10 pm and 9 am. Overall, approximately 31% of cases were transferred. This decreased from 54% of cases in 2013 to 17% in 2015. Rural pilot facilities had an average of 23 eLTC consults per site per year. Averted transfers represent a dramatic benefit to the residents, as potentially avoidable hospitalizations cause undue stress and allow for nosocomial infections, among other risks. In addition, averting these unnecessary transfers likely saved the taxpayers of the United States over $5 million in admission-related charges to Centers for Medicare and Medicaid Services (511 avoided transfers × $11,000 per average hospitalization from a LTC facility). Overall, the eLTC pilot showed promise as a proof-of-concept. The pilot's implementation resulted in increasing utilization and promising reductions in unnecessary transfers to emergency departments and hospitalizations. Copyright © 2016 AMDA – The Society for Post-Acute and Long-Term Care Medicine. All rights reserved.

  5. Barriers to breastfeeding in Lebanon: A policy analysis.

    PubMed

    Akik, Chaza; Ghattas, Hala; Filteau, Suzanne; Knai, Cecile

    2017-08-01

    Although the issue of breastfeeding in Lebanon has risen on the political agenda, the country does not meet international recommendations for early breastfeeding practices. This study analysed barriers to dissemination, implementation, and enforcement of key policies to improve early breastfeeding practices. We conducted interviews with stakeholders in breastfeeding policy in Lebanon and used a framework approach for analysing data. We found a disconnect between policy endorsement and translation on the ground, weak engagement of professional associations and governmental institutions, undue influence by the breast milk substitute industry, and competing priorities-most notably the current refugee crisis. This study highlights the potential policy opportunities to counter these barriers and points to the role of international organisations and grassroots advocacy in pushing, monitoring, and implementing policies that protect breastfeeding, where government capacity is limited, and the private sector is strong.

  6. Emotional valence and contextual affordances flexibly shape approach-avoidance movements

    PubMed Central

    Saraiva, Ana Carolina; Schüür, Friederike; Bestmann, Sven

    2013-01-01

    Behavior is influenced by the emotional content—or valence—of stimuli in our environment. Positive stimuli facilitate approach, whereas negative stimuli facilitate defensive actions such as avoidance (flight) and attack (fight). Facilitation of approach or avoidance movements may also be influenced by whether it is the self that moves relative to a stimulus (self-reference) or the stimulus that moves relative to the self (object-reference), adding flexibility and context-dependence to behavior. Alternatively, facilitation of approach avoidance movements may happen in a pre-defined and muscle-specific way, whereby arm flexion is faster to approach positive (e.g., flexing the arm brings a stimulus closer) and arm extension faster to avoid negative stimuli (e.g., extending the arm moves the stimulus away). While this allows for relatively fast responses, it may compromise the flexibility offered by contextual influences. Here we asked under which conditions approach-avoidance actions are influenced by contextual factors (i.e., reference-frame). We manipulated the reference-frame in which actions occurred by asking participants to move a symbolic manikin (representing the self) toward or away from a positive or negative stimulus, and move a stimulus toward or away from the manikin. We also controlled for the type of movements used to approach or avoid in each reference. We show that the reference-frame influences approach-avoidance actions to emotional stimuli, but additionally we find muscle-specificity for negative stimuli in self-reference contexts. We speculate this muscle-specificity may be a fast and adaptive response to threatening stimuli. Our results confirm that approach-avoidance behavior is flexible and reference-frame dependent, but can be muscle-specific depending on the context and valence of the stimulus. Reference-frame and stimulus-evaluation are key factors in guiding approach-avoidance behavior toward emotional stimuli in our environment. PMID:24379794

  7. 29 CFR 1915.35 - Painting.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... areas within or around the vessel or dry dock. (5) All motors and control equipment shall be of the... sufficient slack to prevent undue stress or chafing. (9) The face, eyes, head, hands, and all other exposed...

  8. Accessible Electronic and Information Technology: Standards, Procedures, and Guidance

    EPA Pesticide Factsheets

    Defines electronic and information technology (EIT), and the technical and functional performance criteria for EIT to comply with Section 508 accessibility standards. Includes EPA procedures for EIT approval, 508 complaints, and undue burden justification.

  9. 75 FR 72781 - Buckhorn Exploration Project 2010, Okanogan-Wenatchee National Forest, Okanogan County, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-26

    ... prevent unnecessary and undue degradation of public lands and surface resources by initially using remote sensing and other non-surface disturbing prospecting techniques to identify target areas. Exploration...

  10. Understanding the receivers and the reception of science's uncertain messages.

    PubMed

    Campbell, Philip

    2011-12-13

    Although much work has been done by scientists in developing communications to non-scientist audiences, much less attention has been given by them to the ways in which those messages are interpreted. Here, I look at the published work that examines the issue. I focus on three contexts in particular: debates over the triple vaccine for measles, mumps and rubella, the impacts of the Soufrière Hills volcano on the inhabitants of the island of Montserrat and the public communication of the results of climate change research. Several common themes emerge. The most important conclusions are that scientists communicating with the public need to develop their methods deliberatively, involving their target audiences; and that they need to avoid undue dependence on traditional media and public authorities for such communication, and to develop multiple channels to those audiences, including Internet-based and more traditional social networks. Their approach to communicating uncertainty should depend on the context but, except in some extreme emergencies, transparency is generally a virtue. Above all, they need to persist in such public engagements even when the going is rough and extends over long periods. They need support in doing so.

  11. Prediction modeling of physiological responses and human performance in the heat with application to space operations

    NASA Technical Reports Server (NTRS)

    Pandolf, Kent B.; Stroschein, Leander A.; Gonzalez, Richard R.; Sawka, Michael N.

    1994-01-01

    This institute has developed a comprehensive USARIEM heat strain model for predicting physiological responses and soldier performance in the heat which has been programmed for use by hand-held calculators, personal computers, and incorporated into the development of a heat strain decision aid. This model deals directly with five major inputs: the clothing worn, the physical work intensity, the state of heat acclimation, the ambient environment (air temperature, relative humidity, wind speed, and solar load), and the accepted heat casualty level. In addition to predicting rectal temperature, heart rate, and sweat loss given the above inputs, our model predicts the expected physical work/rest cycle, the maximum safe physical work time, the estimated recovery time from maximal physical work, and the drinking water requirements associated with each of these situations. This model provides heat injury risk management guidance based on thermal strain predictions from the user specified environmental conditions, soldier characteristics, clothing worn, and the physical work intensity. If heat transfer values for space operations' clothing are known, NASA can use this prediction model to help avoid undue heat strain in astronauts during space flight.

  12. 49 CFR 37.151 - Waiver for undue financial burden.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    .... (b) At the time of its annual plan update submission, if the entity believes that circumstances have changed since its last submission, and it is no longer able to comply by January 26, 1997, or make...

  13. 49 CFR 37.151 - Waiver for undue financial burden.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    .... (b) At the time of its annual plan update submission, if the entity believes that circumstances have changed since its last submission, and it is no longer able to comply by January 26, 1997, or make...

  14. 49 CFR 37.151 - Waiver for undue financial burden.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    .... (b) At the time of its annual plan update submission, if the entity believes that circumstances have changed since its last submission, and it is no longer able to comply by January 26, 1997, or make...

  15. 49 CFR 37.151 - Waiver for undue financial burden.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    .... (b) At the time of its annual plan update submission, if the entity believes that circumstances have changed since its last submission, and it is no longer able to comply by January 26, 1997, or make...

  16. 49 CFR 37.151 - Waiver for undue financial burden.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... (b) At the time of its annual plan update submission, if the entity believes that circumstances have changed since its last submission, and it is no longer able to comply by January 26, 1997, or make...

  17. 10 CFR Appendix B to Part 50 - Quality Assurance Criteria for Nuclear Power Plants and Fuel Reprocessing Plants

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... undue risk to the health and safety of the public. This appendix establishes quality assurance...: reactor physics, stress, thermal, hydraulic, and accident analyses; compatibility of materials...

  18. Government Actions and Interference with Constitutionally Protected Property Rights

    EPA Pesticide Factsheets

    EO to assist Federal departments and agencies in undertaking such reviews and in proposing, planning, and implementing actions to reduce the risk of undue or inadvertent burdens on the public fisc resulting from lawful governmental actions.

  19. 14 CFR 23.231 - Longitudinal stability and control.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Flight Ground... rebound during landing or takeoff. Wheel brakes must operate smoothly and may not induce any undue... characteristics at any normal operating speed on the water. ...

  20. 14 CFR 23.231 - Longitudinal stability and control.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Flight Ground... rebound during landing or takeoff. Wheel brakes must operate smoothly and may not induce any undue... characteristics at any normal operating speed on the water. ...

  1. 14 CFR 23.231 - Longitudinal stability and control.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Flight Ground... rebound during landing or takeoff. Wheel brakes must operate smoothly and may not induce any undue... characteristics at any normal operating speed on the water. ...

  2. 14 CFR 23.231 - Longitudinal stability and control.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Flight Ground... rebound during landing or takeoff. Wheel brakes must operate smoothly and may not induce any undue... characteristics at any normal operating speed on the water. ...

  3. 14 CFR 23.231 - Longitudinal stability and control.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL, UTILITY, ACROBATIC, AND COMMUTER CATEGORY AIRPLANES Flight Ground... rebound during landing or takeoff. Wheel brakes must operate smoothly and may not induce any undue... characteristics at any normal operating speed on the water. ...

  4. Environmental Protection Agency EIT Procurement Checklist for Section 508 Instructions

    EPA Pesticide Factsheets

    Includes examples of items that are considered electronic information technology (EIT), and some that are not, explanations of each exemption and requirement, and how to provide required documentation to justify exemption or undue burden.

  5. Redundant drive current imbalance problem of the Automatic Radiator Inspection Device (ARID)

    NASA Technical Reports Server (NTRS)

    Latino, Carl D.

    1992-01-01

    The Automatic Radiator Inspection Device (ARID) is a 4 Degree of Freedom (DOF) robot with redundant drive motors at each joint. The device is intended to automate the labor intensive task of space shuttle radiator inspection. For safety and redundancy, each joint is driven by two independent motor systems. Motors driving the same joint, however, draw vastly different currents. The concern was that the robot joints could be subjected to undue stress. It was the objective of this summer's project to determine the cause of this current imbalance. In addition it was to determine, in a quantitative manner, what was the cause, how serious the problem was in terms of damage or undue wear to the robot and find solutions if possible. It was concluded that most problems could be resolved with a better motor control design. This document discusses problems encountered and possible solutions.

  6. Influence of dorsolateral prefrontal cortex and ventral striatum on risk avoidance in addiction: a mediation analysis.

    PubMed

    Yamamoto, Dorothy J; Woo, Choong-Wan; Wager, Tor D; Regner, Michael F; Tanabe, Jody

    2015-04-01

    Alterations in frontal and striatal function are hypothesized to underlie risky decision making in drug users, but how these regions interact to affect behavior is incompletely understood. We used mediation analysis to investigate how prefrontal cortex and ventral striatum together influence risk avoidance in abstinent drug users. Thirty-seven abstinent substance-dependent individuals (SDI) and 43 controls underwent fMRI while performing a decision-making task involving risk and reward. Analyses of a priori regions-of-interest tested whether activity in dorsolateral prefrontal cortex (DLPFC) and ventral striatum (VST) explained group differences in risk avoidance. Whole-brain analysis was conducted to identify brain regions influencing the negative VST-risk avoidance relationship. Right DLPFC (RDLPFC) positively mediated the group-risk avoidance relationship (p < 0.05); RDLPFC activity was higher in SDI and predicted higher risk avoidance across groups, controlling for SDI vs. Conversely, VST activity negatively influenced risk avoidance (p < 0.05); it was higher in SDI, and predicted lower risk avoidance. Whole-brain analysis revealed that, across group, RDLPFC and left temporal-parietal junction positively (p ≤ 0.001) while right thalamus and left middle frontal gyrus negatively (p < 0.005) mediated the VST activity-risk avoidance relationship. RDLPFC activity mediated less risky decision making while VST mediated more risky decision making across drug users and controls. These results suggest a dual pathway underlying decision making, which, if imbalanced, may adversely influence choices involving risk. Modeling contributions of multiple brain systems to behavior through mediation analysis could lead to a better understanding of mechanisms of behavior and suggest neuromodulatory treatments for addiction. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  7. Influence of dorsolateral prefrontal cortex and ventral striatum on risk avoidance in addiction: a mediation analysis*

    PubMed Central

    Yamamoto, Dorothy J.; Woo, Choong-Wan; Wager, Tor D.; Regner, Michael F.; Tanabe, Jody

    2015-01-01

    Background Alterations in frontal and striatal function are hypothesized to underlie risky decision-making in drug users, but how these regions interact to affect behavior is incompletely understood. We used mediation analysis to investigate how prefrontal cortex and ventral striatum together influence risk avoidance in abstinent drug users. Method Thirty-seven abstinent substance-dependent individuals (SDI) and 43 controls underwent fMRI while performing a decision-making task involving risk and reward. Analyses of a priori regions-of-interest tested whether activity in dorsolateral prefrontal cortex (DLPFC) and ventral striatum (VST) explained group differences in risk avoidance. Whole-brain analysis was conducted to identify brain regions influencing the negative VST-risk avoidance relationship. Results Right DLPFC (RDLPFC) positively mediated the group-risk avoidance relationship (p < 0.05); RDLPFC activity was higher in SDI and predicted higher risk avoidance across groups, controlling for SDI vs. controls. Conversely, VST activity negatively influenced risk avoidance (p < 0.05); it was higher in SDI, and predicted lower risk avoidance. Whole-brain analysis revealed that, across group, RDLPFC and left temporal-parietal junction positively (p ≤ 0.001) while right thalamus and left middle frontal gyrus negatively (p < 0.005) mediated the VST activity-risk avoidance relationship. Conclusion RDLPFC activity mediated less risky decision-making while VST mediated more risky decision-making across drug users and controls. These results suggest a dual pathway underlying decision-making, which, if imbalanced, may adversely influence choices involving risk. Modeling contributions of multiple brain systems to behavior through mediation analysis could lead to a better understanding of mechanisms of behavior and suggest neuromodulatory treatments for addiction. PMID:25736619

  8. 77 FR 50691 - Request for Information (RFI): Guidance on Data Streamlining and Reducing Undue Reporting Burden...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-22

    .... Attention: HIV Data Streamlining. FOR FURTHER INFORMATION CONTACT: Andrew D. Forsyth Ph.D. or Vera... of HIV/AIDS programs that vary in their specifications (e.g., numerators, denominators, time frames...

  9. 25 CFR 20.504 - What short-term homemaker services can Child Assistance pay for?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... household members in such skills as child care and home management. Homemaker services are provided for: (a... (protective) supervision; (b) A severely handicapped or special needs child whose care places undue stress on...

  10. 25 CFR 20.504 - What short-term homemaker services can Child Assistance pay for?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... household members in such skills as child care and home management. Homemaker services are provided for: (a... (protective) supervision; (b) A severely handicapped or special needs child whose care places undue stress on...

  11. 25 CFR 20.504 - What short-term homemaker services can Child Assistance pay for?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... household members in such skills as child care and home management. Homemaker services are provided for: (a... (protective) supervision; (b) A severely handicapped or special needs child whose care places undue stress on...

  12. 25 CFR 20.504 - What short-term homemaker services can Child Assistance pay for?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... household members in such skills as child care and home management. Homemaker services are provided for: (a... (protective) supervision; (b) A severely handicapped or special needs child whose care places undue stress on...

  13. 25 CFR 20.504 - What short-term homemaker services can Child Assistance pay for?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... household members in such skills as child care and home management. Homemaker services are provided for: (a... (protective) supervision; (b) A severely handicapped or special needs child whose care places undue stress on...

  14. Measuring Urban Sustainability in Time of Climate and Socioeconomic Changes

    EPA Science Inventory

    Natural resource and environmental constraints place a fundamental set of limitation on sustainable urban development. Here the sustainability refers to continuous urban development without undue deterioration of environmental capacity both locally and globally. In this context...

  15. 9 CFR 203.5 - Statement with respect to market agencies paying the expenses of livestock buyers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... sales conducted by such market agencies, such as, expenses for meals, lodging, travel, entertainment and... competition between similarly engaged market agencies and results in undue and unreasonable cost burdens on...

  16. 25 CFR 115.609 - Will you be allowed to present testimony and/or evidence at the hearing?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for... an encumbrance may create an undue financial hardship, if applicable. You may not challenge a court...

  17. 25 CFR 115.609 - Will you be allowed to present testimony and/or evidence at the hearing?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for... an encumbrance may create an undue financial hardship, if applicable. You may not challenge a court...

  18. 25 CFR 115.609 - Will you be allowed to present testimony and/or evidence at the hearing?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for... an encumbrance may create an undue financial hardship, if applicable. You may not challenge a court...

  19. 25 CFR 115.609 - Will you be allowed to present testimony and/or evidence at the hearing?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for... an encumbrance may create an undue financial hardship, if applicable. You may not challenge a court...

  20. 25 CFR 115.609 - Will you be allowed to present testimony and/or evidence at the hearing?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for... an encumbrance may create an undue financial hardship, if applicable. You may not challenge a court...

  1. 14 CFR 25.231 - Longitudinal stability and control.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... takeoff. In addition— (1) Wheel brakes must operate smoothly and may not cause any undue tendency to nose over; and (2) If a tail-wheel landing gear is used, it must be possible, during the takeoff ground run...

  2. 49 CFR 173.32 - Requirements for the use of portable tanks.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... within a nozzle or within a coupling. The installation must be made in such a manner as to reasonably assure that any undue strain which causes failure requiring functioning of the valve shall cause failure...

  3. 49 CFR 173.32 - Requirements for the use of portable tanks.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... within a nozzle or within a coupling. The installation must be made in such a manner as to reasonably assure that any undue strain which causes failure requiring functioning of the valve shall cause failure...

  4. 49 CFR 173.32 - Requirements for the use of portable tanks.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... within a nozzle or within a coupling. The installation must be made in such a manner as to reasonably assure that any undue strain which causes failure requiring functioning of the valve shall cause failure...

  5. 49 CFR 173.32 - Requirements for the use of portable tanks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... within a nozzle or within a coupling. The installation must be made in such a manner as to reasonably assure that any undue strain which causes failure requiring functioning of the valve shall cause failure...

  6. Attachment avoidance predicts inflammatory responses to marital conflict

    PubMed Central

    Gouin, Jean-Philippe; Glaser, Ronald; Loving, Timothy J.; Malarkey, William B.; Stowell, Jeffrey; Houts, Carrie; Kiecolt-Glaser, Janice K.

    2009-01-01

    Marital stress has been associated with immune dysregulation, including increased production of interleukin-6 (IL-6). Attachment style, one’s expectations about the availability and responsiveness of others in intimate relationships, appears to influence physiological stress reactivity and thus could influence inflammatory responses to marital conflict. Thirty-five couples were invited for two 24-hour admissions to a hospital research unit. The first visit included a structured social support interaction, while the second visit comprised the discussion of a marital disagreement. A mixed effect within-subject repeated measure model indicated that attachment avoidance significantly influenced IL-6 production during the conflict visit but not during the social support visit. Individuals with higher attachment avoidance had on average an 11% increase in total IL-6 production during the conflict visit as compared to the social support visit, while individuals with lower attachment avoidance had, on average, a 6% decrease in IL-6 production during the conflict visit as compared to the social support visit. Furthermore, greater attachment avoidance was associated with a higher frequency of negative behaviors and a lower frequency of positive behaviors during the marital interaction, providing a mechanism by which attachment avoidance may influence inflammatory responses to marital conflict. In sum, these results suggest that attachment avoidance modulates marital behavior and stress-induced immune dysregulation. PMID:18952163

  7. Best Interest of the Child and Parental Alienation: A Survey of State Statutes.

    PubMed

    Baker, Amy J L; Asayan, Mariann; LaCheen-Baker, Alianna

    2016-07-01

    State statutes regarding the best interests of the child (BIC) in deciding disputed custody were reviewed and independently coded with respect to three issues (i) the child's preference and any limits (ii) parental alienation and (iii) psychological maltreatment. Results revealed that many states allowed for the child's preferences to be considered and none qualified that preference when undue influence has occurred; parental alienation as a term was not found in any state statutes but 70% of the states included at least one BIC factor relevant to its core construct of the parent supporting the child's relationship to the other parent; and many states included a history of domestic violence or child abuse but only three states explicitly mentioned psychological maltreatment. These findings highlight yet another way in which the BICS factors lack specificity in ways that could negatively impact children caught in their parents' conflict. © 2016 American Academy of Forensic Sciences.

  8. The money blind: how to stop industry bias in biomedical science, without violating the First Amendment.

    PubMed

    Robertson, Christopher T

    2011-01-01

    The pharmaceutical and medical device industries use billions of dollars to support the biomedical science that physicians, regulators, and patients use to make healthcare decisions--the decisions that drive an increasingly large portion of the American economy. Compelling evidence suggests that this industry money buys favorable results, biasing the outcomes of scientific research. Current efforts to manage the problem, including disclosure mandates and peer reviews, are ineffective. A blinding mechanism, operating through an intermediary such as the National Institutes of Health, could instead be developed to allow industry support of science without allowing undue influence. If the editors of biomedical journals fail to mandate that industry funders utilize such a solution, the federal government has several regulatory levers available, including conditioning federal funding and direct regulation, both of which could be done without violating the First Amendment.

  9. The new medical-industrial complex.

    PubMed

    Relman, A S

    1980-10-23

    The most important health-care development of the day is the recent, relatively unheralded rise of a huge new industry that supplies health-care services for profit. Proprietary hospitals and nursing homes, diagnostic laboratories, home-care and emergency-room services, hemodialysis, and a wide variety of other services produced a gross income to this industry last year of about $35 billion to +40 billion. This new "medical-industrial complex" may be more efficient than its nonprofit competition, but it creates the problems of overuse and fragmentation of services, overemphasis on technology, and "cream-skimming," and it may also exercise undue influence on national health policy. In this medical market, physicians must act as discerning purchasing agents for their patients and therefore should have no conflicting financial interests. Closer attention from the public and the profession, and careful study, are necessary to ensure that the "medical-industrial complex" puts the interest of the public before those of its stockholders.

  10. Power in the hypnotic relationship: therapeutic or abusive?

    PubMed

    Walling, D P; Levine, R E

    1997-01-01

    The unique relationship between hypnotist and subject has been theorized as one explanation for the effectiveness of hypnosis. This relationship carries a power differential, present in most therapeutic relationships, but accentuated by hypnosis. The power differential is sometimes perceived as the ability of the hypnotist to control the subject. Perceptions of hypnosis offered by stage hypnotists, the popular media, and some clinicians perpetuate the notion that the hypnotist has the ability to exert undue influence upon the client. The present article examines the relationship between hypnotist and subject focusing on issues of power and control. The authors examine the unique dynamics accompanying the use of hypnosis and their impact on the therapeutic dyad. Evidence is offered demonstrating the power differential, and how this differential can serve as either a positive or negative agent of change. Therapists should be aware of the dynamics created by using hypnosis. Implications for training therapists in the use of hypnosis are suggested.

  11. Strategies of persuasion in offers to participate in cancer clinical trials I: Topic placement and topic framing.

    PubMed

    Barton, Ellen; Eggly, Susan; Winckles, Andrew; Albrecht, Terrance L

    2014-01-01

    Clinical trials are the gold standard in medical research evaluating new treatments in cancer care; however, in the United States, too few patients enroll in trials, especially patients from minority groups. Offering patients the option of a clinical trial is an ethically-charged communicative event for oncologists. One particularly vexed ethical issue is the use of persuasion in trial offers. Based on a corpus of 22 oncology encounters with Caucasian-American (n = 11) and African-American (n = 11) patients, this discourse analysis describes oncologists' use of two persuasive strategies related to the linguistic structure of trial offers: topic placement and topic framing. Findings are presented in total and by patient race, and discussed in terms of whether these strategies may constitute ethical or unethical persuasion, particularly with respect to the ethical issue of undue influence and the social issue of underrepresentation of minorities in cancer clinical trials.

  12. How warm days increase belief in global warming

    NASA Astrophysics Data System (ADS)

    Zaval, Lisa; Keenan, Elizabeth A.; Johnson, Eric J.; Weber, Elke U.

    2014-02-01

    Climate change judgements can depend on whether today seems warmer or colder than usual, termed the local warming effect. Although previous research has demonstrated that this effect occurs, studies have yet to explain why or how temperature abnormalities influence global warming attitudes. A better understanding of the underlying psychology of this effect can help explain the public's reaction to climate change and inform approaches used to communicate the phenomenon. Across five studies, we find evidence of attribute substitution, whereby individuals use less relevant but available information (for example, today's temperature) in place of more diagnostic but less accessible information (for example, global climate change patterns) when making judgements. Moreover, we rule out alternative hypotheses involving climate change labelling and lay mental models. Ultimately, we show that present temperature abnormalities are given undue weight and lead to an overestimation of the frequency of similar past events, thereby increasing belief in and concern for global warming.

  13. The Consultant from Oz Syndrome.

    ERIC Educational Resources Information Center

    Smith, Garnett J.

    1998-01-01

    School leaders should realize that consultants cannot substitute for developing collective actions within the organization. The "Consultant from Oz Syndrome" stems from placing undue confidence in external sources, confusing consultants with magicians, and denying their limitations. While journeying down the yellow brick road of…

  14. 30 CFR 250.202 - What criteria must the Exploration Plan (EP), Development and Production Plan (DPP), or...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 250.202 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT...; and (e) Does not cause undue or serious harm or damage to the human, marine, or coastal environment. ...

  15. 46 CFR 160.171-9 - Construction.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... allow the wearer to jump from a height of at least 4.5 m into the water without injury and without... so that, following a jump from a height of not less than 4.5 m into the water, there is no undue...

  16. 75 FR 39577 - 30-Day Notice of Intention To Request Clearance of Collection of Information; Opportunity for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-09

    ... obligations assumed. It also requires that franchise fees be determined with consideration to the opportunity... that franchise fees can be determined in a timely manner and without an undue burden on the...

  17. 26 CFR 1.6045-1T - Returns of information of brokers and barter exchanges (temporary).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., see § 1.6045-1 (a) through (k). (l) Use of magnetic media. For information returns filed after... magnetic media and for rules relating to waivers granted for undue hardship. For information returns filed...

  18. Budgeting in health care systems.

    PubMed

    Maynard, A

    1984-01-01

    During the last decade there has been a recognition that all health care systems, public and private, are characterised by perverse incentives (especially moral hazard and third party pays) which generate inefficiency in the use of scarce economic resources. Inefficiency is unethical: doctors who use resources inefficiently deprive potential patients of care from which they could benefit. To eradicate unethical and inefficient practices two economic rules have to be followed: (i) no service should be provided if its total costs exceed its total benefits; (ii) if total benefits exceed total costs, the level of provision should be at that level at which the additional input cost (marginal cost) is equal to the additional benefits (marginal benefit). This efficiency test can be applied to health care systems, their component parts and the individuals (especially doctors) who control resource allocation within them. Unfortunately, all health care systems neither generate this relevant decision making data nor are they flexible enough to use it to affect health care decisions. There are two basic varieties of budgeting system: resource based and production targeted. The former generates obsession with cash limits and too little regard of the benefits, particularly at the margins, of alternative patterns of resource allocation. The latter generates undue attention to the production of processes of care and scant regard for costs, especially at the margins. Consequently, one set of budget rules may lead to cost containment regardless of benefits and the other set of budget rules may lead to output maximization regardless of costs. To close this circle of inefficiency it is necessary to evolve market-like structures. To do this a system of client group (defined broadly across all existing activities public and private) budgets is advocated with an identification of the budget holder who has the capacity to shift resources and seek out cost effective policies. Negotiated output targets with defined budgets and incentives for decision makers to economise in their use of resources are being incorporated into experiments in the health care systems of Western Europe and the United States. Undue optimism about the success of these experiments must be avoided because these problems have existed in the West and in the Soviet bloc for decades and efficient solutions are noticeable by their absence.

  19. The Impact of Experiential Avoidance on the Inference of Characters' Emotions: Evidence for an Emotional Processing Bias.

    PubMed

    Pickett, Scott M; Kurby, Christopher A

    2010-12-01

    Experiential avoidance is a functional class of maladaptive strategies that contribute to the development and maintenance of psychopathology. Although previous research has demonstrated group differences in the interpretation of aversive stimuli, there is limited work on the influence of experiential avoidance during the online processing of emotion. An experimental design investigated the influence of self-reported experiential avoidance during emotion processing by assessing emotion inferences during the comprehension of narratives that imply different emotions. Results suggest that experiential avoidance is partially characterized by an emotional information processing bias. Specifically, individuals reporting higher experiential avoidance scores exhibited a bias towards activating negative emotion inferences, whereas individuals reporting lower experiential avoidance scores exhibited a bias towards activating positive emotion inferences. Minimal emotional inference was observed for the non-bias affective valence. Findings are discussed in terms of the implications of experiential avoidance as a cognitive vulnerability for psychopathology.

  20. Disability Discrimination in Higher Education.

    ERIC Educational Resources Information Center

    Weber, Mark C.

    2002-01-01

    Reviews developments in 2000 in the law of disability discrimination as it relates to higher education, which falls into five categories: (1) definition of a qualified individual; (2) accommodations, access, undue burden, and fundamental alteration of programs; (3) intentional discrimination, harassment, and retaliation; (4) Eleventh Amendment…

  1. 76 FR 19476 - Exelon Generation Company, LLC, Peach Bottom Atomic Power Station, Unit Nos. 2 and 3; Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ... licensee stated that the floor-based combustibles include health physics cleaning supplies, such as mops... undue risk to public health or safety, and are consistent with the common defense and security; and (2...

  2. 34 CFR 303.420 - Due process procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... infant's or toddler's development is so rapid that undue delay could be potentially harmful. [58 FR 40959... AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND... Children § 303.420 Due process procedures. Each system must include written procedures including procedures...

  3. 34 CFR 303.420 - Due process procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... infant's or toddler's development is so rapid that undue delay could be potentially harmful. [58 FR 40959... AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION EARLY INTERVENTION PROGRAM FOR INFANTS AND... Children § 303.420 Due process procedures. Each system must include written procedures including procedures...

  4. 14 CFR 380.26 - Discrimination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Discrimination. 380.26 Section 380.26... REGULATIONS PUBLIC CHARTERS Requirements Applicable to Charter Operators § 380.26 Discrimination. No charter... unjust discrimination or any undue or unreasonable prejudice or disadvantage in any respect whatsoever. ...

  5. 14 CFR 372.22 - Discrimination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Discrimination. 372.22 Section 372.22... REGULATIONS OVERSEAS MILITARY PERSONNEL CHARTERS Conditions and Limitations § 372.22 Discrimination. No... any unjust discrimination or any undue or unreasonable prejudice or disadvantage in any respect...

  6. 14 CFR 372.22 - Discrimination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Discrimination. 372.22 Section 372.22... REGULATIONS OVERSEAS MILITARY PERSONNEL CHARTERS Conditions and Limitations § 372.22 Discrimination. No... any unjust discrimination or any undue or unreasonable prejudice or disadvantage in any respect...

  7. 14 CFR 380.26 - Discrimination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Discrimination. 380.26 Section 380.26... REGULATIONS PUBLIC CHARTERS Requirements Applicable to Charter Operators § 380.26 Discrimination. No charter... unjust discrimination or any undue or unreasonable prejudice or disadvantage in any respect whatsoever. ...

  8. 14 CFR 380.26 - Discrimination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Discrimination. 380.26 Section 380.26... REGULATIONS PUBLIC CHARTERS Requirements Applicable to Charter Operators § 380.26 Discrimination. No charter... unjust discrimination or any undue or unreasonable prejudice or disadvantage in any respect whatsoever. ...

  9. 14 CFR 372.22 - Discrimination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Discrimination. 372.22 Section 372.22... REGULATIONS OVERSEAS MILITARY PERSONNEL CHARTERS Conditions and Limitations § 372.22 Discrimination. No... any unjust discrimination or any undue or unreasonable prejudice or disadvantage in any respect...

  10. 14 CFR 380.26 - Discrimination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Discrimination. 380.26 Section 380.26... REGULATIONS PUBLIC CHARTERS Requirements Applicable to Charter Operators § 380.26 Discrimination. No charter... unjust discrimination or any undue or unreasonable prejudice or disadvantage in any respect whatsoever. ...

  11. 14 CFR 372.22 - Discrimination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Discrimination. 372.22 Section 372.22... REGULATIONS OVERSEAS MILITARY PERSONNEL CHARTERS Conditions and Limitations § 372.22 Discrimination. No... any unjust discrimination or any undue or unreasonable prejudice or disadvantage in any respect...

  12. 14 CFR 380.26 - Discrimination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Discrimination. 380.26 Section 380.26... REGULATIONS PUBLIC CHARTERS Requirements Applicable to Charter Operators § 380.26 Discrimination. No charter... unjust discrimination or any undue or unreasonable prejudice or disadvantage in any respect whatsoever. ...

  13. 14 CFR 372.22 - Discrimination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Discrimination. 372.22 Section 372.22... REGULATIONS OVERSEAS MILITARY PERSONNEL CHARTERS Conditions and Limitations § 372.22 Discrimination. No... any unjust discrimination or any undue or unreasonable prejudice or disadvantage in any respect...

  14. 75 FR 4838 - 60-Day Notice of Intention To Request Clearance of Collection of Information; Opportunity for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... franchise fees be determined with consideration to the opportunity for net profit in relation to both gross... franchise fees determined in a timely manner and without an undue burden on the concessioner. This program...

  15. 5 CFR 1636.160 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE FEDERAL RETIREMENT THRIFT INVESTMENT BOARD... would result in a fundamental alteration in the nature of a program or activity or in undue financial...

  16. 22 CFR 711.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ....150 Section 711.150 Foreign Relations OVERSEAS PRIVATE INVESTMENT CORPORATION ADMINISTRATIVE... THE OVERSEAS PRIVATE INVESTMENT CORPORATION § 711.150 Program accessibility: Existing facilities. (a... result in a fundamental alteration in the nature of a program or activity or in undue financial and...

  17. Handbook of Reasonable Accommodation.

    ERIC Educational Resources Information Center

    Heaton, Sandra M.; And Others

    The booklet discusses a basic concept in affirmative action and nondiscrimination for the handicapped, which requires federal agencies to make reasonable accommodation to the physical or mental limitations of a qualified handicapped applicant or employee unless the accommodation would impose an undue hardship on the agency. Reasonable…

  18. 77 FR 62482 - Fisheries of the Exclusive Economic Zone Off Alaska; Bering Sea and Aleutian Islands Management...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-15

    .../ Ps and Amendment 80 cooperatives from undue compliance costs stemming from the mandatory GRS rates... estimates may stem from differences in the data used in the analysis for the GRS program to calculate the...

  19. 26 CFR 1.6045-1T - Returns of information of brokers and barter exchanges (temporary).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... guidance, see § 1.6045-1 (a) through (k). (l) Use of magnetic media. For information returns filed after... magnetic media and for rules relating to waivers granted for undue hardship. For information returns filed...

  20. 7 CFR 1207.506 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN... in order to help maintain and expand existing domestic and foreign markets for potatoes and to... projects which will provide maximum benefit to the potato industry and no undue preference shall be given...

  1. 7 CFR 1207.506 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE POTATO RESEARCH AND PROMOTION PLAN... in order to help maintain and expand existing domestic and foreign markets for potatoes and to... projects which will provide maximum benefit to the potato industry and no undue preference shall be given...

  2. No Child Left Unchallenged

    ERIC Educational Resources Information Center

    Beigie, Darin

    2011-01-01

    Providing student choice and opportunities for independent study are recognized as viable differentiation techniques. Daily homework sets that contain more demanding problems even though not required allow the teacher to provide challenge without incurring undue stress. The modest incentive of some homework bonus points is enough to whet the…

  3. 29 CFR 1915.36 - Flammable liquids.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... sufficient slack to prevent undue stress or chafing. (6) Suitable fire extinguishing equipment shall be immediately available in the work area and shall be maintained in a state of readiness for instant use. ...

  4. 29 CFR 1915.36 - Flammable liquids.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... sufficient slack to prevent undue stress or chafing. (6) Suitable fire extinguishing equipment shall be immediately available in the work area and shall be maintained in a state of readiness for instant use. ...

  5. 29 CFR 1915.36 - Flammable liquids.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... sufficient slack to prevent undue stress or chafing. (6) Suitable fire extinguishing equipment shall be immediately available in the work area and shall be maintained in a state of readiness for instant use. ...

  6. 29 CFR 1915.36 - Flammable liquids.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... sufficient slack to prevent undue stress or chafing. (6) Suitable fire extinguishing equipment shall be immediately available in the work area and shall be maintained in a state of readiness for instant use. ...

  7. 29 CFR 1915.36 - Flammable liquids.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR... sufficient slack to prevent undue stress or chafing. (6) Suitable fire extinguishing equipment shall be immediately available in the work area and shall be maintained in a state of readiness for instant use. ...

  8. Summer-Time Fun and Learning.

    ERIC Educational Resources Information Center

    Murphy, Linda; Della Corte, Suzanne

    1988-01-01

    The newsletter for parents of handicapped children focuses on summer activities which provide fun and learning without undue expense or effort. Suggestions include encouraging reading activities (including visiting the library, reading out loud, selective television viewing, making a book, and writing letters). Activities to encourage the child's…

  9. A New Key Unlocks Dormitory Financing.

    ERIC Educational Resources Information Center

    Ransdell, Gary A.

    2000-01-01

    Describes how one university creatively financed its dormitory renovation without imposing undue hardships on students (and with approval from of the university's governing board and elected state leaders). Planners developed a nonprofit foundation to fund the recapitalization and renovation of the dormitories. The foundation owned the…

  10. 24 CFR 7.15 - Responsibilities of managers and supervisors.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Opportunity Without Regard to Race, Color Religion, Sex, National Origin, Age, Disability or Reprisal... sound management and personnel practices; (g) Resolving complaints of discrimination early in the EEO... accommodations can be made without undue hardship on the business of the Department; (i) Attending mandatory...

  11. 24 CFR 8.11 - Reasonable accommodation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... make reasonable accommodation to the known physical or mental limitations of an otherwise qualified... accommodation would impose an undue hardship on the operation of its program. (b) Reasonable accommodation may... hardship on the operation of a recipient's program, factors to be considered include: (1) The overall size...

  12. 10 CFR 4.123 - Reasonable accommodation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... shall make reasonable accommodation to the known physical or mental limitations of an otherwise... would impose an undue hardship on the operation of its program or activity. (b) Reasonable accommodation... on the operation of a recipient's program or activity, factors to be considered include: (1) The...

  13. 24 CFR 26.44 - Protective orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HEARING PROCEDURES Hearings Pursuant to the Administrative Procedure Act Discovery § 26.44 Protective... respect to discovery sought by an opposing party or with respect to the hearing, seeking to limit the..., or undue burden or expense because: (1) The discovery sought is unreasonably cumulative or...

  14. 7 CFR 12.23 - Conservation plans and conservation systems.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... to produce agricultural commodities prior to December 23, 1985, the applicable conservation systems... available conservation technology; cost-effective; and shall not cause undue economic hardship on the person... containing highly erodible cropland which was used to produce an agricultural commodity prior to December 23...

  15. 48 CFR 32.607-2 - Deferment of collection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... financially weak contractors, balancing the need for Government security against loss and undue hardship on... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Deferment of collection. 32.607-2 Section 32.607-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION...

  16. 5 CFR 1636.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... facilities. 1636.150 Section 1636.150 Administrative Personnel FEDERAL RETIREMENT THRIFT INVESTMENT BOARD... RETIREMENT THRIFT INVESTMENT BOARD § 1636.150 Program accessibility: Existing facilities. (a) General. The... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

  17. A Hydraulically Operated Pine Cone Cutter

    Treesearch

    Carl W. Fatzinger; M.T. Proveaux

    1971-01-01

    Mature cones of slash pine (Pinus elliottii Engelm. var. elliottii) and longleaf pine (P. palustris Mill.) can be easily bisected along their longitudinal axes with the hydraulic pine cone cutter described. This cutter eliminates the two major problems of earlier models--undue operator fatigue and the...

  18. 16 CFR 6.152 - Program accessibility: Electronic and information technology.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... information technology. 6.152 Section 6.152 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION... information technology. (a) When developing, procuring, maintaining, or using electronic and information technology, the Commission shall ensure, unless an undue burden would be imposed on the agency, that the...

  19. Why are natural disasters not 'natural' for victims?

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kumagai, Yoshitaka; Edwards, John; Carroll, Matthew S.

    Some type of formal or informal social assessment is often carried out in the wake of natural disasters. One often-observed phenomenon in such situations is that disaster victims and their sympathizers tend to focus on those elements of disasters that might have been avoided or mitigated by human intervention and thus assign 'undue' levels of responsibility to human agents. Often the responsibility or blame is directed at the very government agencies charged with helping people cope with and recover from the event. This phenomenon presents particular challenges for those trying to understand the social impacts of such events because ofmore » the reflexive nature of such analysis. Often the social analyst or even the government agency manager must sort through such perceptions and behavior and (at least implicitly) make judgments about which assignments of responsibility may have some validity and which are largely the result of the psychology of the disaster itself. This article presents a conceptual framework derived largely from social psychology to help develop a better understand such perceptions and behavior. While no 'magic bullet' formula for evaluating the validity of disaster victims' claims is presented, the conceptual framework is presented as a starting point for understanding this particular aspect of the psychology of natural disasters.« less

  20. Validation of the Choking Risk Assessment and Pneumonia Risk Assessment for adults with Intellectual and Developmental Disability (IDD).

    PubMed

    Sheppard, Justine Joan; Malandraki, Georgia A; Pifer, Paula; Cuff, Jill; Troche, Michelle; Hemsley, Bronwyn; Balandin, Susan; Mishra, Avinash; Hochman, Roberta

    2017-10-01

    Risk assessments are needed to identify adults with intellectual and developmental disability (IDD) at high risk of choking and pneumonia. To describe the development and validation of the Choking Risk Assessment (CRA) and the Pneumonia Risk Assessment (PRA) for adults with IDD. Test items were identified through literature review and focus groups. Five-year retrospective chart reviews identified a positive choking group (PCG), a negative choking group (NCG), a positive pneumonia group (PPG), and a negative pneumonia group (NPG). Participants were tested with the CRA and PRA by clinicians blind to these testing conditions. The CRA and PRA differentiated the PCG (n=93) from the NCG (n=526) and the PPG (n=63) from the NPG (n=209) with high specificity (0.91 and 0.92 respectively) and moderate to average sensitivity (0.53 and 0.62 respectively). Further analyses revealed associations between clinical diagnoses of dysphagia and choking (p=0.043), and pneumonia (p<0.001). The CRA and PRA are reliable, valid risk indicators for choking and pneumonia in adults with IDD. Precautions for mitigating choking and pneumonia risks can be applied selectively thus avoiding undue impacts on quality of life and unnecessary interventions for low risk individuals. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. Control Law Design for Propofol Infusion to Regulate Depth of Hypnosis: A Nonlinear Control Strategy

    PubMed Central

    Khaqan, Ali; Bilal, Muhammad; Ilyas, Muhammad; Ijaz, Bilal; Ali Riaz, Raja

    2016-01-01

    Maintaining the depth of hypnosis (DOH) during surgery is one of the major objectives of anesthesia infusion system. Continuous administration of Propofol infusion during surgical procedures is essential but increases the undue load of an anesthetist in operating room working in a multitasking setup. Manual and target controlled infusion (TCI) systems are not good at handling instabilities like blood pressure changes and heart rate variability arising due to interpatient variability. Patient safety, large interindividual variability, and less postoperative effects are the main factors to motivate automation in anesthesia. The idea of automated system for Propofol infusion excites the control engineers to come up with a more sophisticated and safe system that handles optimum delivery of drug during surgery and avoids postoperative effects. In contrast to most of the investigations with linear control strategies, the originality of this research work lies in employing a nonlinear control technique, backstepping, to track the desired hypnosis level of patients during surgery. This effort is envisioned to unleash the true capabilities of this nonlinear control technique for anesthesia systems used today in biomedical field. The working of the designed controller is studied on the real dataset of five patients undergoing surgery. The controller tracks the desired hypnosis level within the acceptable range for surgery. PMID:27293475

  2. Control Law Design for Propofol Infusion to Regulate Depth of Hypnosis: A Nonlinear Control Strategy.

    PubMed

    Khaqan, Ali; Bilal, Muhammad; Ilyas, Muhammad; Ijaz, Bilal; Ali Riaz, Raja

    2015-01-01

    Maintaining the depth of hypnosis (DOH) during surgery is one of the major objectives of anesthesia infusion system. Continuous administration of Propofol infusion during surgical procedures is essential but increases the undue load of an anesthetist in operating room working in a multitasking setup. Manual and target controlled infusion (TCI) systems are not good at handling instabilities like blood pressure changes and heart rate variability arising due to interpatient variability. Patient safety, large interindividual variability, and less postoperative effects are the main factors to motivate automation in anesthesia. The idea of automated system for Propofol infusion excites the control engineers to come up with a more sophisticated and safe system that handles optimum delivery of drug during surgery and avoids postoperative effects. In contrast to most of the investigations with linear control strategies, the originality of this research work lies in employing a nonlinear control technique, backstepping, to track the desired hypnosis level of patients during surgery. This effort is envisioned to unleash the true capabilities of this nonlinear control technique for anesthesia systems used today in biomedical field. The working of the designed controller is studied on the real dataset of five patients undergoing surgery. The controller tracks the desired hypnosis level within the acceptable range for surgery.

  3. 5 CFR 723.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... facilities. 723.150 Section 723.150 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL... ACTIVITIES CONDUCTED BY THE OFFICE OF PERSONNEL MANAGEMENT § 723.150 Program accessibility: Existing... would result in a fundamental alteration in the nature of a program or activity or in undue financial...

  4. 41 CFR 105-8.160 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Communications. 105-8.160 Section 105-8.160 Public Contracts and Property Management Federal Property Management Regulations... would result in a fundamental alteration in the nature of a program or activity or in undue financial...

  5. 24 CFR 3280.608 - Hangers and supports.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Hangers and supports. (a) Strains and stresses. Piping in a plumbing system shall be installed without undue strains and stresses, and provision shall be made for expansion, contraction, and structural..., plastic drainage piping shall be supported at intervals not to exceed 4 feet and plastic water piping...

  6. 24 CFR 3280.608 - Hangers and supports.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Hangers and supports. (a) Strains and stresses. Piping in a plumbing system shall be installed without undue strains and stresses, and provision shall be made for expansion, contraction, and structural..., plastic drainage piping shall be supported at intervals not to exceed 4 feet and plastic water piping...

  7. 10 CFR 820.62 - Criteria.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... granting an exemption to a DOE Nuclear Safety Requirement are determinations that the exemption: (a) Would be authorized by law; (b) Would not present an undue risk to public health and safety, the... similarly situated; or (4) The exemption would result in benefit to human health and safety that compensates...

  8. 10 CFR 820.62 - Criteria.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... granting an exemption to a DOE Nuclear Safety Requirement are determinations that the exemption: (a) Would be authorized by law; (b) Would not present an undue risk to public health and safety, the... similarly situated; or (4) The exemption would result in benefit to human health and safety that compensates...

  9. 10 CFR 820.62 - Criteria.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... granting an exemption to a DOE Nuclear Safety Requirement are determinations that the exemption: (a) Would be authorized by law; (b) Would not present an undue risk to public health and safety, the... similarly situated; or (4) The exemption would result in benefit to human health and safety that compensates...

  10. 10 CFR 820.62 - Criteria.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... granting an exemption to a DOE Nuclear Safety Requirement are determinations that the exemption: (a) Would be authorized by law; (b) Would not present an undue risk to public health and safety, the... similarly situated; or (4) The exemption would result in benefit to human health and safety that compensates...

  11. 10 CFR 820.62 - Criteria.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... granting an exemption to a DOE Nuclear Safety Requirement are determinations that the exemption: (a) Would be authorized by law; (b) Would not present an undue risk to public health and safety, the... similarly situated; or (4) The exemption would result in benefit to human health and safety that compensates...

  12. 30 CFR 285.621 - What must I demonstrate in my COP?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Section 285.621 Mineral Resources BUREAU OF OCEAN ENERGY MANAGEMENT, REGULATION, AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR OFFSHORE RENEWABLE ENERGY ALTERNATE USES OF EXISTING FACILITIES ON THE OUTER... undue harm or damage to natural resources; life (including human and wildlife); property; the marine...

  13. 22 CFR 530.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE BROADCASTING BOARD OF GOVERNORS... or activity so that the program or activity, when viewed in its entirety, is readily accessible to... activity or in undue financial and administrative burdens. In those circumstances where Board personnel...

  14. 46 CFR 507.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE FEDERAL MARITIME COMMISSION... or activity so that the program or activity, when viewed in its entirety, is readily accessible to... activity or in undue financial and administrative burdens. In those circumstances where agency personnel...

  15. 1 CFR 500.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE NATIONAL COMMISSION FOR EMPLOYMENT POLICY... or activity so that the program or activity, when viewed in its entirety, is readily accessible to... activity or in undue financial and administrative burdens. In those circumstances where agency personnel...

  16. 49 CFR 1014.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE SURFACE TRANSPORTATION BOARD... or activity so that the program or activity, when viewed in its entirety, is readily accessible to... activity or in undue financial and administrative burdens. In those circumstances where agency personnel...

  17. Do Environmental and Energy Goals Clash?

    ERIC Educational Resources Information Center

    Environmental Science and Technology, 1974

    1974-01-01

    To meet energy needs, the World's energy base must be broadly diversified. This diversification, including such possibilities as fossil fuels, nuclear, solar, geothermal, tidal and aeolian energy, must proceed without undue environmental damage and be economically feasible. Compromises between energy, economics and the environment will have to be…

  18. 12 CFR 352.5 - Accessibility to electronic and information technology.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... and information technology. (a) In accordance with section 508 of the Rehabilitation Act, the FDIC shall ensure, absent an undue burden, that the electronic and information technology the agency develops... or procurement of electronic and information technology that meets the standards published by the...

  19. 12 CFR 352.5 - Accessibility to electronic and information technology.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... and information technology. (a) In accordance with section 508 of the Rehabilitation Act, the FDIC shall ensure, absent an undue burden, that the electronic and information technology the agency develops... or procurement of electronic and information technology that meets the standards published by the...

  20. 12 CFR 352.5 - Accessibility to electronic and information technology.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... and information technology. (a) In accordance with section 508 of the Rehabilitation Act, the FDIC shall ensure, absent an undue burden, that the electronic and information technology the agency develops... or procurement of electronic and information technology that meets the standards published by the...

  1. 12 CFR 352.5 - Accessibility to electronic and information technology.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and information technology. (a) In accordance with section 508 of the Rehabilitation Act, the FDIC shall ensure, absent an undue burden, that the electronic and information technology the agency develops... or procurement of electronic and information technology that meets the standards published by the...

  2. 5 CFR 950.401 - Campaign and publicity information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... publicity information. Federations must also respond in a timely fashion in the development of campaign and.... (f) Campaign information must constitute a simple and attractive design that has fundraising appeal and essential working information. The design should focus on the CFC without undue use of charitable...

  3. 12 CFR 1408.8 - Right to offer to repay claim.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... would create a financial hardship, the Corporation shall analyze the debtor's financial condition. The... an undue financial hardship for the debtor. The written agreement shall set forth the amount and... of the consequences of signing a confess-judgment note. The debtor shall sign a statement...

  4. Using regional freight traffic assignment modeling to quantify the variability of pavement damage for highway cost allocation and revenue analysis.

    DOT National Transportation Integrated Search

    2014-12-01

    While indicative of a vibrant economy, large volumes of freight traffic have been associated with : accelerated wear of pavements particularly. In seeking to adopt operational policies that reduce : undue deterioration of their infrastructure, state ...

  5. 12 CFR 352.5 - Accessibility to electronic and information technology.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... technology. 352.5 Section 352.5 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND... and information technology. (a) In accordance with section 508 of the Rehabilitation Act, the FDIC shall ensure, absent an undue burden, that the electronic and information technology the agency develops...

  6. The relative effectiveness of managed care penetration and the healthcare safety net in reducing avoidable hospitalizations.

    PubMed

    Pracht, Etienne E; Orban, Barbara L; Comins, Meg M; Large, John T; Asin-Oostburg, Virginia

    2011-01-01

    Avoidable hospitalizations represent a key indicator for access to, and the quality of, primary care. Therefore, understanding their behavior is essential in terms of management of healthcare resources and costs. This analysis examines the affect of 2 healthcare strategies on the rate of avoidable hospitalization, managed care and the healthcare safety net. The avoidable hospitalizations definition developed by Weissman et al. (1992) was used to identify relevant inpatient episodes. A 2-stage simultaneous equations multivariate regression model with instrumental variables was used to estimate the relative influence of HMO penetration and the composition of local hospital markets on the rate of avoidable hospitalizations. Control variables in the model include healthcare supply and demand, demographic, socioeconomic, and health status characteristics. Increased market presence of public hospitals significantly reduced avoidable hospitalizations. HMO penetration did not influence the rate of avoidable hospitalizations. The results suggest that public investments in healthcare facilities and infrastructure are more effective in reducing avoidable hospitalizations. © 2011 National Association for Healthcare Quality.

  7. The Other Danger... Scholasticism in Academic Research

    ERIC Educational Resources Information Center

    Mead, Lawrence M.

    2010-01-01

    Most members of the National Association of Scholars worry about the politicization of the university. Academia gives undue preference to racial minorities in student admissions and faculty appointments. Teaching and research is often slanted toward minority grievances and Third World claims against the United States. However, critics have largely…

  8. 29 CFR 33.12 - Complaint handling procedures.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... that resolution of the complaint would require a fundamental alteration of the program or undue... Management (Deputy ASAM). (i) If informal resolution is not achieved, the Deputy ASAM shall issue a... Administration and Management (ASAM). (j)(1) An appeal of the Deputy ASAM's determination may be filed with the...

  9. 41 CFR 51-10.160 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Communications. 51-10.160 Section 51-10.160 Public Contracts and Property Management Other Provisions Relating to Public Contracts... would result in a fundamental alteration in the nature of a program or activity or in undue financial...

  10. 28 CFR 0.19 - Associate Attorney General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Director, Office of Attorney Recruitment and Management. (c) The Associate Attorney General is the Attorney... can achieve the purpose of a program without fundamental changes in its nature, and whether an action would result in a fundamental alteration in the nature of a program or activity or in undue financial...

  11. 41 CFR 51-10.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Program accessibility: Existing facilities. 51-10.150 Section 51-10.150 Public Contracts and Property Management Other Provisions... result in a fundamental alteration in the nature of a program or activity or in undue financial and...

  12. 49 CFR 178.704 - General IBC standards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... sift-proof and water-resistant. (b) All service equipment must be so positioned or protected as to..., without loss of hazardous materials, the internal pressure of the contents and the stresses of normal... transportation without gross distortion or failure and must be positioned so as to cause no undue stress in any...

  13. What Is Plan B? Using Foucault's Archaeology to Enhance Policy Analysis

    ERIC Educational Resources Information Center

    Bourke, Terri; Lidstone, John

    2015-01-01

    Many governments in Western democracies conduct the work of leading their societies forward through policy generation and implementation. Despite government attempts at extensive negotiation, collaboration and debate, the general populace in these same countries frequently express feelings of disempowerment and undue pressure to be compliant,…

  14. 50 CFR 17.23 - Economic hardship permits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 2 2010-10-01 2010-10-01 false Economic hardship permits. 17.23 Section... Economic hardship permits. Upon receipt of a complete application, the Director may issue a permit... section in order to prevent undue economic hardship. The Director shall publish notice in the Federal...

  15. 50 CFR 17.63 - Economic hardship permits.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 2 2010-10-01 2010-10-01 false Economic hardship permits. 17.63 Section... Economic hardship permits. Upon receipt of a complete application, the Director may issue a permit... issuance criteria of this section, in order to prevent undue economic hardship. No such exemption may be...

  16. Marker development

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Adams, M.R.

    This report is to discuss the marker development for radioactive waste disposal sites. The markers must be designed to last 10,000 years, and place no undue burdens on the future generations. Barriers cannot be constructed that preclude human intrusion. Design specifications for surface markers will be discussed, also marker pictograms will also be covered.

  17. 14 CFR 16.215 - Depositions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... testimony of the witness; or (3) The taking of the deposition is necessary to prevent undue and excessive... application shall include: (1) The name and residence of the witness; (2) The time and place for the taking of... found, or refuses to sign. The reporter shall note the reason for failure to sign. ...

  18. 14 CFR 16.215 - Depositions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... testimony of the witness; or (3) The taking of the deposition is necessary to prevent undue and excessive... application shall include: (1) The name and residence of the witness; (2) The time and place for the taking of... found, or refuses to sign. The reporter shall note the reason for failure to sign. ...

  19. 22 CFR 521.24 - Protective order.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Relations BROADCASTING BOARD OF GOVERNORS IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 521.24... with respect to discovery sought by an opposing party or, with respect to the hearing, seeking to limit... undue burden or expense, including one or more of the following: (1) That the discovery not be had; (2...

  20. 22 CFR 224.24 - Protective order.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Relations AGENCY FOR INTERNATIONAL DEVELOPMENT IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT § 224... protective order with respect to discovery sought by an opposing party or, with respect to the hearing..., oppression, or undue burden or expense, including one or more of the following: (1) That the discovery not be...

  1. 28 CFR 71.24 - Protective order.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FRAUD CIVIL REMEDIES ACT OF 1986 Implementation for Actions Initiated by the Department of Justice § 71... protective order with respect to discovery sought by an opposing party or with respect to the hearing..., oppression, or undue burden or expense, including one or more of the following: (1) That the discovery not be...

  2. 7 CFR 1962.40 - Liquidation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... borrower. (2) Lien search. The County Supervisor will obtain a current lien search report to determine the... searches should be obtained from the same source as is used when making a loan. If obtaining the searches from third party sources causes undue delay which interferes with orderly liquidation, searches may be...

  3. 7 CFR 1962.40 - Liquidation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... borrower. (2) Lien search. The County Supervisor will obtain a current lien search report to determine the... searches should be obtained from the same source as is used when making a loan. If obtaining the searches from third party sources causes undue delay which interferes with orderly liquidation, searches may be...

  4. 7 CFR 1962.40 - Liquidation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... borrower. (2) Lien search. The County Supervisor will obtain a current lien search report to determine the... searches should be obtained from the same source as is used when making a loan. If obtaining the searches from third party sources causes undue delay which interferes with orderly liquidation, searches may be...

  5. 7 CFR 1962.40 - Liquidation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... borrower. (2) Lien search. The County Supervisor will obtain a current lien search report to determine the... searches should be obtained from the same source as is used when making a loan. If obtaining the searches from third party sources causes undue delay which interferes with orderly liquidation, searches may be...

  6. Revictimizing the Victims? Interviewing Women about Interpersonal Violence

    ERIC Educational Resources Information Center

    Hlavka, Heather R.; Kruttschnitt, Candace; Carbone-Lopez, Kristin C.

    2007-01-01

    Research on women's experiences of interpersonal violence has grown dramatically and, as a result, the ethical issues surrounding this research are a concern. Although regulatory procedures ensure that research participants are protected from undue risk, little is known about the impact of victimization research on participants. In this study, the…

  7. Development of a Special Provision on the Use of Pervious Concrete As a Stormwater Management Tool in Parking Lots

    DOT National Transportation Integrated Search

    2017-11-01

    The abundance of impervious surfaces in developed areas leads to increased threats from stormwater runoff. The contaminants carried in unmanaged stormwater runoff in addition to higher volumes of water damage the natural environment and put undue str...

  8. 17 CFR 200.650 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the Basis of Handicap in Programs or Activities Conducted by the Securities and Exchange Commission... or activity so that the program or activity, when viewed in its entirety, is readily accessible to... the nature of a program or activity or in undue financial and administrative burdens. In those...

  9. 45 CFR 1175.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE NATIONAL ENDOWMENT FOR THE... program or activity so that the program or activity, when viewed in its entirety, is readily accessible to... of a program or activity or in undue financial and administrative burdens. In those circumstances...

  10. 7 CFR 15e.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES DEPARTMENT OF AGRICULTURE... or activity so that the program or activity, when viewed in its entirety, is readily accessible to... the nature of a program or activity or in undue financial and administrative burdens. In those...

  11. 6 CFR 15.50 - Program accessibility; existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF DISABILITY IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE... Department shall operate each program or activity so that the program or activity, when viewed in its... result in a fundamental alteration in the nature of a program or activity or in undue financial and...

  12. 25 CFR 720.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE NAVAJO AND HOPI INDIAN RELOCATION... program or activity so that the program or activity, when viewed in its entirety, is readily accessible to... activity or in undue financial and administrative burdens. In those circumstances where agency personnel...

  13. 38 CFR 15.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... AFFAIRS ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY.... The agency shall operate each program or activity so that the program or activity, when viewed in its... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

  14. 22 CFR 219.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY INTERNATIONAL DEVELOPMENT.... (a) General. The agency shall operate each program or activity so that the program or activity, when... result in a fundamental alteration in the nature of a program or activity or in undue financial and...

  15. 16 CFR 6.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OF PRACTICE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES.... The Commission shall operate each program or activity so that the program or activity, when viewed in... demonstrate would result in a fundamental alteration in the nature of a program or activity or in undue...

  16. 22 CFR 1510.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE AFRICAN DEVELOPMENT FOUNDATION... or activity so that the program or activity, when viewed in its entirety, is readily accessible to... the nature of a program or activity or in undue financial and administrative burdens. In those...

  17. 22 CFR 144.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES DEPARTMENT OF... program or activity so that the program or activity, when viewed in its entirety, is readily accessible to... activity or in undue financial and administrative burdens. In those circumstances where agency personnel...

  18. 24 CFR 9.150 - Program accessibility: existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ACTIVITIES CONDUCTED BY THE DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT § 9.150 Program accessibility... shall operate each program or activity so that the program or activity, when viewed in its entirety, is... nature of a program or activity or in undue financial and administrative burdens. In those circumstances...

  19. 5 CFR 1850.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE OFFICE OF SPECIAL COUNSEL... or activity so that the program or activity, when viewed in its entirety, is readily accessible to... the nature of a program or activity or in undue financial and administrative burdens. In those...

  20. 49 CFR 28.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF TRANSPORTATION § 28... or activity so that the program or activity, when viewed in its entirety, is readily accessible to... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

  1. 36 CFR 812.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... HISTORIC PRESERVATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES... facilities. (a) General. The agency shall operate each program or activity so that the program or activity... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

  2. 12 CFR 606.650 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE FARM CREDIT... program or activity so that the program or activity, when viewed in its entirety, is readily accessible to... the nature of a program or activity or in undue financial and administrative burdens. In those...

  3. 3 CFR 102.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE EXECUTIVE OFFICE OF THE PRESIDENT... or activity so that the program or activity, when viewed in its entirety, is readily accessible to... the nature of a program or activity or in undue financial and administrative burdens. In those...

  4. 18 CFR 1313.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... AUTHORITY ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY... agency shall operate each program or activity so that the program or activity, when viewed in its... the nature of a program or activity or in undue financial and administrative burdens. In those...

  5. 29 CFR 2205.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY... facilities. (a) General. The agency shall operate each program or activity so that the program or activity... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

  6. 45 CFR 606.51 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... FOUNDATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY... Foundation shall operate each program or activity so that the program or activity, when viewed in its... result in a fundamental alteration in the nature of a program or activity or in undue financial and...

  7. 29 CFR 100.550 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Enforcement of Nondiscrimination on the Basis of Handicap in Programs or Activities Conducted by the National... shall operate each program or activity so that the program or activity, when viewed in its entirety, is... the nature of a program or activity or in undue financial and administrative burdens. In those...

  8. 40 CFR 12.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE ENVIRONMENTAL PROTECTION... program or activity so that the program or activity, when viewed in its entirety, is readily accessible to... the nature of a program or activity or in undue financial and administrative burdens. In those...

  9. 45 CFR 1214.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ACTIVITIES CONDUCTED BY ACTION § 1214.150 Program accessibility: Existing facilities. (a) General. The agency shall operate each program or activity so that the program or activity, when viewed in its entirety, is... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

  10. 29 CFR 2706.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY... facilities. (a) General. The agency shall operate each program or activity so that the program or activity... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

  11. 22 CFR 1701.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE UNITED STATES INSTITUTE OF... program or activity so that the program or activity, when viewed in its entirety, is readily accessible to... the nature of a program or activity or in undue financial and administrative burdens. In those...

  12. 36 CFR 909.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DEVELOPMENT CORPORATION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES... facilities. (a) General. The agency shall operate each program or activity so that the program or activity... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

  13. 5 CFR 2416.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE FEDERAL... shall operate each program or activity so that the program or activity, when viewed in its entirety, is... fundamental alteration in the nature of a program or activity or in undue financial and administrative burdens...

  14. 17 CFR 149.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... COMMISSION ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY...) General. The agency shall operate each program or activity so that the program or activity, when viewed in... the nature of a program or activity or in undue financial and administrative burdens. In those...

  15. 45 CFR 1181.150 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE INSTITUTE OF MUSEUM AND... operate each program or activity so that the program or activity, when viewed in its entirety, is readily... the nature of a program or activity or in undue financial and administrative burdens. In those...

  16. 12 CFR 268.102 - Board program for equal employment opportunity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Commission's Management Directives; (3) Conduct a continuing campaign to eradicate every form of prejudice or... candidates without regard to race, color, religion, sex, national origin, age or disability, and solicit... when those accommodations can be made without undue hardship on the business of the Board; (8) Make...

  17. Effects of group-selection timber harvest in bottomland hardwoods on fall migrant birds

    Treesearch

    John C. Kilgo; Karl V. Miller; Winston P. Smith

    1999-01-01

    Due to projected demands for hardwood timber, development of silvicultural practices that provide for adequate regeneration in southeastern bottomland hardwoods without causing undue harm to wildlife resources is critical. Group-selection silviculture involves harvesting a small group of trees, which creates a canopy gap (usually

  18. Unplanned Nutrition Education in the Schools: Sugar in Elementary Reading Texts.

    ERIC Educational Resources Information Center

    D'Onofrio, Carol N.; Singer, Rosalind

    1983-01-01

    Analysis of the foods described or pictured in over 1,600 readers, prereaders, and reading workbooks for the primary grades revealed an undue emphasis on sweets. Reading texts should be screened for unintentional messages about nutrition and sugary foods, and revised to reflect national dietary goals. (Author/PP)

  19. 50 CFR 17.23 - Economic hardship permits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 2 2011-10-01 2011-10-01 false Economic hardship permits. 17.23 Section... Economic hardship permits. Upon receipt of a complete application, the Director may issue a permit... section in order to prevent undue economic hardship. The Director shall publish notice in the Federal...

  20. 50 CFR 17.63 - Economic hardship permits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 2 2013-10-01 2013-10-01 false Economic hardship permits. 17.63 Section... Economic hardship permits. Upon receipt of a complete application, the Director may issue a permit... issuance criteria of this section, in order to prevent undue economic hardship. No such exemption may be...

  1. 50 CFR 17.63 - Economic hardship permits.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 2 2012-10-01 2012-10-01 false Economic hardship permits. 17.63 Section... Economic hardship permits. Upon receipt of a complete application, the Director may issue a permit... issuance criteria of this section, in order to prevent undue economic hardship. No such exemption may be...

  2. 50 CFR 17.23 - Economic hardship permits.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 2 2013-10-01 2013-10-01 false Economic hardship permits. 17.23 Section... Economic hardship permits. Upon receipt of a complete application, the Director may issue a permit... section in order to prevent undue economic hardship. The Director shall publish notice in the Federal...

  3. 50 CFR 17.63 - Economic hardship permits.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 2 2011-10-01 2011-10-01 false Economic hardship permits. 17.63 Section... Economic hardship permits. Upon receipt of a complete application, the Director may issue a permit... issuance criteria of this section, in order to prevent undue economic hardship. No such exemption may be...

  4. 50 CFR 17.23 - Economic hardship permits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 2 2014-10-01 2014-10-01 false Economic hardship permits. 17.23 Section... Economic hardship permits. Upon receipt of a complete application, the Director may issue a permit... section in order to prevent undue economic hardship. The Director shall publish notice in the Federal...

  5. 50 CFR 17.23 - Economic hardship permits.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 2 2012-10-01 2012-10-01 false Economic hardship permits. 17.23 Section... Economic hardship permits. Upon receipt of a complete application, the Director may issue a permit... section in order to prevent undue economic hardship. The Director shall publish notice in the Federal...

  6. 50 CFR 17.63 - Economic hardship permits.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 2 2014-10-01 2014-10-01 false Economic hardship permits. 17.63 Section... Economic hardship permits. Upon receipt of a complete application, the Director may issue a permit... issuance criteria of this section, in order to prevent undue economic hardship. No such exemption may be...

  7. 40 CFR 270.14 - Contents of part B: General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... strata, surface water, or air, which may include the installation of wells, where the Director ascertains... water supplies; (iv) Mitigate effects of equipment failure and power outages; (v) Prevent undue exposure... contour interval must be sufficient to clearly show the pattern of surface water flow in the vicinity of...

  8. Time: Assessing Understanding of Core Ideas

    ERIC Educational Resources Information Center

    Thomas, Margaret; McDonough, Andrea; Clarkson, Philip; Clarke, Doug

    2016-01-01

    Although an understanding of time is crucial in our society, curriculum documents have an undue emphasis on reading time and little emphasis on core underlying ideas. Given this context, a one-to-one assessment interview, based on a new framework, was developed and administered to investigate students' understanding of core ideas undergirding the…

  9. 49 CFR 192.161 - Supports and anchors.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) Prevent undue strain on connected equipment; (2) Resist longitudinal forces caused by a bend or offset in the pipe; and (3) Prevent or damp out excessive vibration. (b) Each exposed pipeline must have enough supports or anchors to protect the exposed pipe joints from the maximum end force caused by internal...

  10. 49 CFR 192.161 - Supports and anchors.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) Prevent undue strain on connected equipment; (2) Resist longitudinal forces caused by a bend or offset in the pipe; and (3) Prevent or damp out excessive vibration. (b) Each exposed pipeline must have enough supports or anchors to protect the exposed pipe joints from the maximum end force caused by internal...

  11. 49 CFR 192.161 - Supports and anchors.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) Prevent undue strain on connected equipment; (2) Resist longitudinal forces caused by a bend or offset in the pipe; and (3) Prevent or damp out excessive vibration. (b) Each exposed pipeline must have enough supports or anchors to protect the exposed pipe joints from the maximum end force caused by internal...

  12. 49 CFR 192.161 - Supports and anchors.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Prevent undue strain on connected equipment; (2) Resist longitudinal forces caused by a bend or offset in the pipe; and (3) Prevent or damp out excessive vibration. (b) Each exposed pipeline must have enough supports or anchors to protect the exposed pipe joints from the maximum end force caused by internal...

  13. 49 CFR 192.161 - Supports and anchors.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) Prevent undue strain on connected equipment; (2) Resist longitudinal forces caused by a bend or offset in the pipe; and (3) Prevent or damp out excessive vibration. (b) Each exposed pipeline must have enough supports or anchors to protect the exposed pipe joints from the maximum end force caused by internal...

  14. 22 CFR 126.3 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Exceptions. 126.3 Section 126.3 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS GENERAL POLICIES AND PROVISIONS § 126.3 Exceptions. In a case of exceptional or undue hardship, or when it is otherwise in the interest...

  15. 22 CFR 126.3 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Exceptions. 126.3 Section 126.3 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS GENERAL POLICIES AND PROVISIONS § 126.3 Exceptions. In a case of exceptional or undue hardship, or when it is otherwise in the interest...

  16. 22 CFR 126.3 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exceptions. 126.3 Section 126.3 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS GENERAL POLICIES AND PROVISIONS § 126.3 Exceptions. In a case of exceptional or undue hardship, or when it is otherwise in the interest...

  17. 22 CFR 126.3 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Exceptions. 126.3 Section 126.3 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS GENERAL POLICIES AND PROVISIONS § 126.3 Exceptions. In a case of exceptional or undue hardship, or when it is otherwise in the interest...

  18. 38 CFR 21.3021 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...) VOCATIONAL REHABILITATION AND EDUCATION Survivors' and Dependents' Educational Assistance Under 38 U.S.C... would not be in his or her best interest, would result in undue delay or would not be administratively feasible. Where necessary to protect his or her interest and there is reason why the eligible person should...

  19. 12 CFR 1402.12 - Identification of records requested.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Identification of records requested. 1402.12 Section 1402.12 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION RELEASING INFORMATION... information as to dates, titles, and subject matter, so that such records may be located without undue search...

  20. 48 CFR 970.5215-3 - Conditional payment of fee, profit, and other incentives-facility management contracts

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND.... Financial incentives for timely mission accomplishment or cost effectiveness shall never compromise or..., undue risk to the common defense and security. In addition, this category includes performance failures...

  1. 48 CFR 970.5215-3 - Conditional payment of fee, profit, and other incentives-facility management contracts

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND.... Financial incentives for timely mission accomplishment or cost effectiveness shall never compromise or..., undue risk to the common defense and security. In addition, this category includes performance failures...

  2. 48 CFR 970.5215-3 - Conditional payment of fee, profit, and other incentives-facility management contracts

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND.... Financial incentives for timely mission accomplishment or cost effectiveness shall never compromise or..., undue risk to the common defense and security. In addition, this category includes performance failures...

  3. 78 FR 15040 - Renewal of Approved Information Collection

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-08

    ... authorized by the mining laws, and in obtaining financial guarantees for the reclamation of public lands. The... the General Mining Law (43 CFR subpart 3809). Forms: Form 3809-1, Surface Management Surety Bond; Form... whether operators and mining claimants are meeting their responsibility to prevent unnecessary or undue...

  4. 14 CFR 21.43 - Location of manufacturing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Location of manufacturing facilities. 21.43... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.43 Location of manufacturing facilities... location of the manufacturer's facilities places no undue burden on the FAA in administering applicable...

  5. 10 CFR 960.5-2-9 - Rock characteristics.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., or location of an underground facility. (2) In situ characteristics and conditions that could require... undue hazard to personnel; and (3) the requirements specified in § 960.5-1(a)(3) can be met. (b... significant flexibility in selecting the depth, configuration, and location of the underground facility. (2) A...

  6. 10 CFR 960.5-2-9 - Rock characteristics.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., or location of an underground facility. (2) In situ characteristics and conditions that could require... undue hazard to personnel; and (3) the requirements specified in § 960.5-1(a)(3) can be met. (b... significant flexibility in selecting the depth, configuration, and location of the underground facility. (2) A...

  7. 10 CFR 960.5-2-9 - Rock characteristics.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., or location of an underground facility. (2) In situ characteristics and conditions that could require... undue hazard to personnel; and (3) the requirements specified in § 960.5-1(a)(3) can be met. (b... significant flexibility in selecting the depth, configuration, and location of the underground facility. (2) A...

  8. 43 CFR 3275.12 - What environmental and safety requirements apply to facility operations?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... that: (1) Protects the quality of surface and subsurface waters, air, and other natural resources, including wildlife, soil, vegetation, and natural history; (2) Prevents unnecessary or undue degradation of the lands; (3) Protects the quality of cultural, scenic, and recreational resources; (4) Accommodates...

  9. 48 CFR 39.204 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... requirements in 39.203 do not apply to EIT that— (a) Is purchased in accordance with Subpart 13.2 (micro-purchases) prior to April 1, 2005. However, for micro-purchases, contracting officers and other individuals... writing the basis for an undue burden decision and provide the documentation to the contracting officer...

  10. Contribution of parents' adult attachment and separation attitudes to parent-adolescent conflict resolution.

    PubMed

    García-Ruiz, Marta; Rodrigo, María José; Hernández-Cabrera, Juan A; Máiquez, María Luisa

    2013-12-01

    This study examined the contribution to parent-adolescent conflict resolution of parental adult attachment styles and attitudes toward adolescent separation. Questionnaires were completed by 295 couples with early to late adolescent children. Structural equation models were used to test self and partner influences on conflict resolution for three attachment orientations: confidence (model A), anxiety (model B) and avoidance (model C). Model A showed self influences between parents' confidence orientation and negotiation and also via positive attitudes towards separation. Also, the fathers' use of negotiation was facilitated by the mothers' confidence orientation and vice versa, indicating partner influences as well. Model B showed self influences between parents' anxiety orientation and the use of dominance and withdrawal and also via negative attitudes towards separation. Model C showed self influences between parents' avoidance orientation and dominance and withdrawal, and a partner influence between fathers' avoidance and mothers' use of dominance. The results indicated that the parents' adult attachment system and the parenting system were related in the area of conflict resolution, and that self influences were stronger than partner influences. © 2013 The Scandinavian Psychological Associations.

  11. [Comparative analysis of metabotropic and ionotropic glutamate striatal receptors blockade influence on rats locomotor behaviour].

    PubMed

    Iakimovskiĭ, A F; Kerko, T V

    2013-02-01

    The influence of NMDA and metabotropic neostriatal glutamate receptors blockade to avoidance conditioning (in shuttle box) and free locomotor behavior (in open field) in chronic experiments in rats were investigated. The glutamate receptor antagonists were injected bilateral into striatum separately and with the GABA-A receptor antagonist picrotoxin (2 microg), that produced in rats the impairment of avoidance conditioning and choreo-myoklonic hyperkinesis. The most effective in preventing of negative picrotoxin influence on behavior was 5-type metabotropic glutamate receptors antagonist MTEP (3 microg). Separately injected MTEP did not influence on avoidance conditioning and free locomotor behavior. Unlike that, 1-type metabotropic glutamate receptors antagonist EMQMCM (3 microg) impaired normal locomotor behavior and did not prevent the picrotoxin effects. The NMDA glutamate receptors MK 801 (disocilpin--1 and 5 microg) impaired the picrotoxin-induced hyperkinesis, but did not to prevent the negative effects on avoidance conditioning; separately injected MK 801 reduced free locomotor activity. Based on location of investigated receptor types in neostriatal neurons membranes, we proposed that the most effective influence on 5-type metabotropic glutamate receptors is associated with their involvement in "indirect" efferent pathway, suffered in hyperkinetic extrapyramidal motor dysfunction--Huntington's chorea in human.

  12. The law regarding health records of the deceased in the UK.

    PubMed

    Dimond, Bridgit

    Case Scenario: Following the death in hospital of a patient, John, a dispute has arisen over his will and the allocation of his property. He married twice and had a son from each marriage who have never got on well with each other. In his will he left his terraced house to the son, Bruce, who most frequently visited him at home and in hospital. The other son, Ben, however, feels that Bruce exerted undue influence upon the father and that the property should have been equally divided between the two of them in the absence of any other relatives. He also believes that his father lacked the necessary mental capacity when he made his will and, therefore, the will is also invalid on those grounds. Ben is seeking to access his father's health records to try and establish the mental state of his father at the time he made the will. He has applied to see the records. Will he be able to access them?

  13. Financial Decision-making Abilities and Financial Exploitation in Older African Americans: Preliminary Validity Evidence for the Lichtenberg Financial Decision Rating Scale (LFDRS)

    PubMed Central

    Ficker, Lisa J.; Rahman-Filipiak, Annalise

    2015-01-01

    This study examines preliminary evidence for the Lichtenberg Financial Decision Rating Scale (LFDRS), a new person-centered approach to assessing capacity to make financial decisions, and its relationship to self-reported cases of financial exploitation in 69 older African Americans. More than one third of individuals reporting financial exploitation also had questionable decisional abilities. Overall, decisional ability score and current decision total were significantly associated with cognitive screening test and financial ability scores, demonstrating good criterion validity. Financially exploited individuals, and non-exploited individuals, showed mean group differences on the Mini Mental State Exam, Financial Situational Awareness, Psychological Vulnerability, Current Decisional Ability, and Susceptibility to undue influence subscales, and Total Lichtenberg Financial Decision Rating Scale Score. Study findings suggest that impaired decisional abilities may render older adults more vulnerable to financial exploitation, and that the LFDRS is a valid tool for measuring both decisional abilities and financial exploitation. PMID:26285038

  14. Social media and organ donation: Ethically navigating the next frontier.

    PubMed

    Henderson, M L; Clayville, K A; Fisher, J S; Kuntz, K K; Mysel, H; Purnell, T S; Schaffer, R L; Sherman, L A; Willock, E P; Gordon, E J

    2017-11-01

    As the organ shortage continues to grow, the creation of social media communities by transplant hospitals and the public is rapidly expanding to increase the number of living donors. Social media communities are arranged in myriad ways and without standardization, raising concerns about transplant candidates' and potential donors' autonomy and quality of care. Social media communities magnify and modify extant ethical issues in deceased and living donation related to privacy, confidentiality, professionalism, and informed consent, and increase the potential for undue influence and coercion for potential donors and transplant candidates. Currently, no national ethical guidelines have been developed in the United States regarding the use of social media to foster organ transplantation. We provide an ethical framework to guide transplant stakeholders in using social media for public and patient communication about transplantation and living donation, and offer recommendations for transplant clinical practice and future research. © 2017 The American Society of Transplantation and the American Society of Transplant Surgeons.

  15. Aerothermodynamic testing requirements for future space transportation systems

    NASA Technical Reports Server (NTRS)

    Paulson, John W., Jr.; Miller, Charles G., III

    1995-01-01

    Aerothermodynamics, encompassing aerodynamics, aeroheating, and fluid dynamic and physical processes, is the genesis for the design and development of advanced space transportation vehicles. It provides crucial information to other disciplines involved in the development process such as structures, materials, propulsion, and avionics. Sources of aerothermodynamic information include ground-based facilities, computational fluid dynamic (CFD) and engineering computer codes, and flight experiments. Utilization of this triad is required to provide the optimum requirements while reducing undue design conservatism, risk, and cost. This paper discusses the role of ground-based facilities in the design of future space transportation system concepts. Testing methodology is addressed, including the iterative approach often required for the assessment and optimization of configurations from an aerothermodynamic perspective. The influence of vehicle shape and the transition from parametric studies for optimization to benchmark studies for final design and establishment of the flight data book is discussed. Future aerothermodynamic testing requirements including the need for new facilities are also presented.

  16. Parties heed (with caution)

    PubMed Central

    Fisher, Justin

    2011-01-01

    Despite comprehensive reform (Political Parties, Elections and Referendums Act) and recent review (Phillips Review in 2007) of party finance in Britain, public opinion of party finance remains plagued by perceptions of corruption, undue influence from wealthy donors, carefree and wasteful spending and, more generally, from the perception that there is just ‘too much money’ in politics. In this article we argue that knowledge of and attitudes to party finance matter, not least because advocates of reform have cited public opinion as evidence for reform. However, because attitudes to party finance are part of a broader attitudinal structure, opinion-led reforms are unlikely to succeed in increasing public confidence. Using data generated from YouGov’s online panel (N=2,008), we demonstrate that the public know little of the key provisions regulating party finance and attitudes to party finance can be explained along two underlying dimensions – Anti-Party Finance and Reformers. As such, we consider whether parties and politicians should be freed from the constraints of public opinion in reforming party finance. PMID:29097904

  17. Improving Core Strength to Prevent Injury

    ERIC Educational Resources Information Center

    Oliver, Gretchen D.; Adams-Blair, Heather R.

    2010-01-01

    Regardless of the sport or skill, it is essential to have correct biomechanical positioning, or postural control, in order to maximize energy transfer. Correct postural control requires a strong, stable core. A strong and stable core allows one to transfer energy effectively as well as reduce undue stress. An unstable or weak core, on the other…

  18. 76 FR 67377 - Anglers for Christ Ministries, Inc., New Beginning Ministries; Petitioners; Interpretation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-01

    ... following factors in making an undue burden determination: (1) The nature and cost of the closed captions... Commission concludes that the reasoning used in the Anglers Order for evaluating requests for exemption from... previously applied to decisions that predate the Anglers Order. 6. In addition, the Commission reverses the...

  19. 75 FR 3355 - Guidelines and Requirements for Mandatory Recall Notices

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-21

    ... particular, several commenters are concerned about harm that could occur to business reputation based on the... recall. Finally, the Commission rejects the idea that a recall notice causes undue harm to business... the harm, the same level of detail may not be necessary for every recall to be helpful to consumers...

  20. Decline as a disease category: Is it helpful?

    Treesearch

    M.E. Ostry; R.C. Venette; J. Juzwik

    2011-01-01

    Many, but not all, forest pathologists use "decline" to describe forest tree diseases of complex etiology. We contend that this distinction from abiotic or biotic diseases is completely arbitrary, has caused undue confusion, and provides no practical insights for forest managers. All diseases are complex and can be characterized within the conceptual...

  1. Higher Education in Ethiopia: Expansion, Quality Assurance and Institutional Autonomy

    ERIC Educational Resources Information Center

    Akalu, Girmaw Abebe

    2014-01-01

    This article chronicles the key challenges facing Ethiopia as it embarks on an ambitious, ideologically-driven and aggressive expansion of its higher education system in an effort to address its national goals of economic growth and poverty reduction. It is argued that the urge for higher education expansion has placed undue pressures particularly…

  2. 49 CFR 178.915 - General Large Packaging standards.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    .... Large Packagings intended for solid hazardous materials must be sift-proof and water-resistant. (b) All... materials, the internal pressure of the contents and the stresses of normal handling and transport. A Large... without gross distortion or failure and must be positioned so as to cause no undue stress in any part of...

  3. 49 CFR 178.915 - General Large Packaging standards.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... intended for solid hazardous materials must be sift-proof and water-resistant. (b) All service equipment... internal pressure of the contents and the stresses of normal handling and transport. A Large Packaging... gross distortion or failure and must be positioned so as to cause no undue stress in any part of the...

  4. DRDC Toronto Guidelines for Compensation of Subjects Participating in Research Studies

    DTIC Science & Technology

    2008-09-01

    research subject, it is increasingly likely to amount to an undue incentive for participation.” The Tri-Council Policy statement also describes in... spirometry equipment 0 Tilt table restrictive posture 1 Wrist actigraphy 0 Use of active heating or cooling vests to prevent the fall or rise of core

  5. 14 CFR 16.215 - Depositions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... testimony of the witness; or (3) The taking of the deposition is necessary to prevent undue and excessive... application shall include: (1) The name and residence of the witness; (2) The time and place for the taking of... found, or refuses to sign. The reporter shall note the reason for failure to sign. (e) Depositions of...

  6. 20 CFR 902.4 - Access to records.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... in writing to the Executive Director, Joint Board for the Enrollment of Actuaries, c/o Department of... without undue difficulty. (c) Fees. A fee at the rate of $5.00 per hour or fraction thereof or the time... with such request for records and shall immediately notify in writing the person making such request of...

  7. 20 CFR 902.4 - Access to records.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... in writing to the Executive Director, Joint Board for the Enrollment of Actuaries, c/o Department of... without undue difficulty. (c) Fees. A fee at the rate of $5.00 per hour or fraction thereof or the time... with such request for records and shall immediately notify in writing the person making such request of...

  8. 20 CFR 902.4 - Access to records.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... in writing to the Executive Director, Joint Board for the Enrollment of Actuaries, c/o Department of... without undue difficulty. (c) Fees. A fee at the rate of $5.00 per hour or fraction thereof or the time... with such request for records and shall immediately notify in writing the person making such request of...

  9. 20 CFR 902.4 - Access to records.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... in writing to the Executive Director, Joint Board for the Enrollment of Actuaries, c/o Department of... without undue difficulty. (c) Fees. A fee at the rate of $5.00 per hour or fraction thereof or the time... with such request for records and shall immediately notify in writing the person making such request of...

  10. Assessing Language Proficiency Levels: Oral Proficiency Testing, Pre- and Post-Soviet Study.

    ERIC Educational Resources Information Center

    Baker, Robert L.

    The importance of assessing language proficiency levels and the relationship of this priority to the teaching of Russian at the university level are discussed. Serious concerns about the value of language-specific proficiency guidelines are raised, and an argument is presented suggesting that language-specific guidelines may lead to undue emphasis…

  11. 7 CFR 3565.213 - Geographic distribution.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... market of properties subject to a Agency guaranteed loan. The Agency will consider the credit quality of the loan and overall market conditions in making a determination of undue risk. If any of the Agency guaranteed loans in the market are experiencing vacancy rates in excess of 15% and the vacancy is due to...

  12. 7 CFR 3565.213 - Geographic distribution.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... market of properties subject to a Agency guaranteed loan. The Agency will consider the credit quality of the loan and overall market conditions in making a determination of undue risk. If any of the Agency guaranteed loans in the market are experiencing vacancy rates in excess of 15% and the vacancy is due to...

  13. 7 CFR 3565.213 - Geographic distribution.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... market of properties subject to a Agency guaranteed loan. The Agency will consider the credit quality of the loan and overall market conditions in making a determination of undue risk. If any of the Agency guaranteed loans in the market are experiencing vacancy rates in excess of 15% and the vacancy is due to...

  14. 7 CFR 3565.213 - Geographic distribution.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... market of properties subject to a Agency guaranteed loan. The Agency will consider the credit quality of the loan and overall market conditions in making a determination of undue risk. If any of the Agency guaranteed loans in the market are experiencing vacancy rates in excess of 15% and the vacancy is due to...

  15. 7 CFR 3565.213 - Geographic distribution.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... market of properties subject to a Agency guaranteed loan. The Agency will consider the credit quality of the loan and overall market conditions in making a determination of undue risk. If any of the Agency guaranteed loans in the market are experiencing vacancy rates in excess of 15% and the vacancy is due to...

  16. 43 CFR 17.550 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... on the Basis of Handicap in Programs or Activities Conducted by the Department of the Interior § 17... activity so that the program or activity, when viewed in its entirety, is readily accessible to and usable... the nature of a program or activity or in undue financial and administrative burdens. In those...

  17. 45 CFR 85.42 - Program accessibility: Existing facilities.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE DEPARTMENT OF HEALTH AND HUMAN... program or activity so that the program or activity, when viewed in its entirety, is readily accessible to... the nature of a program or activity or in undue financial and administrative burdens. In those...

  18. 45 CFR 2554.30 - Are protective orders available?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... COMMUNITY SERVICE PROGRAM FRAUD CIVIL REMEDIES ACT REGULATIONS Hearing Provisions § 2554.30 Are protective... order with respect to discovery sought by an opposing party or with respect to the hearing, seeking to..., oppression, or undue burden or expense, including one or more of the following: (1) That the discovery not be...

  19. At Wake Forest U., Admissions Has Become "More Art than Science"

    ERIC Educational Resources Information Center

    Hoover, Eric

    2009-01-01

    The admissions process is awash in numbers. Students accumulate grade-point averages and test scores. Colleges use statistical models to predict enrollment outcomes, and they tout their place in commercial rankings. In many ways, numbers simplify this complex enterprise. However, they have come to carry undue weight, says Martha Blevins Allman,…

  20. 25 CFR 115.616 - What information will be included in BIA's final decision?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...? 115.616 Section 115.616 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM... applicable; (d) Any provision to allow for distributions to the account holder because of an undue financial...

  1. 25 CFR 115.616 - What information will be included in BIA's final decision?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...? 115.616 Section 115.616 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM... applicable; (d) Any provision to allow for distributions to the account holder because of an undue financial...

  2. 25 CFR 115.616 - What information will be included in BIA's final decision?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...? 115.616 Section 115.616 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM... applicable; (d) Any provision to allow for distributions to the account holder because of an undue financial...

  3. 25 CFR 115.616 - What information will be included in BIA's final decision?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...? 115.616 Section 115.616 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM... applicable; (d) Any provision to allow for distributions to the account holder because of an undue financial...

  4. 25 CFR 115.616 - What information will be included in BIA's final decision?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...? 115.616 Section 115.616 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES TRUST FUNDS FOR TRIBES AND INDIVIDUAL INDIANS IIM Accounts: Hearing Process for Restricting an IIM... applicable; (d) Any provision to allow for distributions to the account holder because of an undue financial...

  5. 76 FR 63541 - Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... Hurricane Missiles for Nuclear Power Plants AGENCY: Nuclear Regulatory Commission. ACTION: Regulatory guide... regulatory guide, (RG) 1.221, ``Design-Basis Hurricane and Hurricane Missiles for Nuclear Power Plants... missiles that a nuclear power plant should be designed to withstand to prevent undue risk to the health and...

  6. Preventing Lead Poisoning in Young Children: A Statement by the Center for Disease Control.

    ERIC Educational Resources Information Center

    Center for Disease Control (DHEW/PHS), Atlanta, GA.

    The purpose of this statement by the Center for Disease Control is to reflect new data available from clinical, epidemiological and experimental studies by making revised recommendations regarding the screening, diagnosis, treatment, and followup of children with undue lead absorption and lead poisoning. The ultimate preventive goal is…

  7. 33 CFR 165.125 - Regulated Navigation Area; EPA Superfund Site, New Bedford Harbor, Massachusetts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... undue risk to environmental remediation efforts. Requests for waivers should be submitted in writing to... vessels or persons engaged in activities associated with remediation efforts in the New Bedford Harbor... advance notice of those activities by the U.S. Environmental Protection Agency (EPA). (c) Waivers. The...

  8. 33 CFR 165.125 - Regulated Navigation Area; EPA Superfund Site, New Bedford Harbor, Massachusetts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... undue risk to environmental remediation efforts. Requests for waivers should be submitted in writing to... vessels or persons engaged in activities associated with remediation efforts in the New Bedford Harbor... advance notice of those activities by the U.S. Environmental Protection Agency (EPA). (c) Waivers. The...

  9. 33 CFR 165.125 - Regulated Navigation Area; EPA Superfund Site, New Bedford Harbor, Massachusetts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... undue risk to environmental remediation efforts. Requests for waivers should be submitted in writing to... vessels or persons engaged in activities associated with remediation efforts in the New Bedford Harbor... advance notice of those activities by the U.S. Environmental Protection Agency (EPA). (c) Waivers. The...

  10. 33 CFR 165.125 - Regulated Navigation Area; EPA Superfund Site, New Bedford Harbor, Massachusetts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... undue risk to environmental remediation efforts. Requests for waivers should be submitted in writing to... vessels or persons engaged in activities associated with remediation efforts in the New Bedford Harbor... advance notice of those activities by the U.S. Environmental Protection Agency (EPA). (c) Waivers. The...

  11. 7 CFR 1599.11 - Use of commodities and sale proceeds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... forces or any government or insurgent group without the specific authorization of FAS. (d) A participant... FAS determines that this requirement would constitute an undue burden. (f) A participant may use sale... written approval from FAS. (g) A participant shall endeavor to comply with §§ 3019.41 through 3019.43 of...

  12. 7 CFR 1499.11 - Use of commodities and sale proceeds.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... forces or any government or insurgent group without the specific authorization of FAS. (d) A participant... FAS determines that this requirement would constitute an undue burden. (f) A participant may use sale... written approval from FAS. (g) A participant shall endeavor to comply with §§ 3019.41 through 3019.43 of...

  13. 7 CFR 1499.11 - Use of commodities and sale proceeds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... forces or any government or insurgent group without the specific authorization of FAS. (d) A participant... FAS determines that this requirement would constitute an undue burden. (f) A participant may use sale... written approval from FAS. (g) A participant shall endeavor to comply with §§ 3019.41 through 3019.43 of...

  14. 7 CFR 1599.11 - Use of commodities and sale proceeds.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... forces or any government or insurgent group without the specific authorization of FAS. (d) A participant... FAS determines that this requirement would constitute an undue burden. (f) A participant may use sale... written approval from FAS. (g) A participant shall endeavor to comply with §§ 3019.41 through 3019.43 of...

  15. 7 CFR 1599.11 - Use of commodities and sale proceeds.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... forces or any government or insurgent group without the specific authorization of FAS. (d) A participant... FAS determines that this requirement would constitute an undue burden. (f) A participant may use sale... written approval from FAS. (g) A participant shall endeavor to comply with §§ 3019.41 through 3019.43 of...

  16. 7 CFR 1599.11 - Use of commodities and sale proceeds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... forces or any government or insurgent group without the specific authorization of FAS. (d) A participant... FAS determines that this requirement would constitute an undue burden. (f) A participant may use sale... written approval from FAS. (g) A participant shall endeavor to comply with §§ 3019.41 through 3019.43 of...

  17. 7 CFR 1599.11 - Use of commodities and sale proceeds.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... forces or any government or insurgent group without the specific authorization of FAS. (d) A participant... FAS determines that this requirement would constitute an undue burden. (f) A participant may use sale... written approval from FAS. (g) A participant shall endeavor to comply with §§ 3019.41 through 3019.43 of...

  18. 78 FR 72124 - Information Collection Request; Submission for OMB Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... INFORMATION: Method: Applicants gain access to the form via a secure online portal. Applicants have to... perform the essential functions of a Peace Corps Volunteer and complete a tour of service without undue... functions of the Peace Corps, including whether the information will have practical use; the accuracy of the...

  19. 77 FR 50191 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Order Instituting Proceedings To...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-20

    ... compete with the algorithms that member firms and other market participants currently use to achieve VWAP... orders generated by market participants that may choose to use a competing algorithm. IV. Procedure... offer trading algorithms that would compete with other market participants would impose an undue burden...

  20. The Revitalization of Physical Fitness in the United States.

    ERIC Educational Resources Information Center

    Conrad, C. Carson

    The author, Executive Director of the President's Council on Physical Fitness and Sport (PCPFS), describes the efforts of the Council in improving the fitness levels of Americans through research, information dissemination, and action programs. Defined as the "ability to carry out daily tasks with vigor and alertness, without undue fatigue,…

  1. 40 CFR 270.290 - What general types of information must I keep at my facility?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... and power outages, (5) Prevent undue exposure of personnel to hazardous waste (for example, requiring.... (n) [Reserved] (o) The most recent closure cost estimate for your facility prepared under 40 CFR 267... land uses (residential, commercial, agricultural, recreational). (5) A wind rose (i.e., prevailing wind...

  2. 40 CFR 270.290 - What general types of information must I keep at my facility?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... and power outages, (5) Prevent undue exposure of personnel to hazardous waste (for example, requiring.... (n) [Reserved] (o) The most recent closure cost estimate for your facility prepared under 40 CFR 267... land uses (residential, commercial, agricultural, recreational). (5) A wind rose (i.e., prevailing wind...

  3. Managing Depth and Breadth in the Business Spanish Course

    ERIC Educational Resources Information Center

    Houston, Tony

    2015-01-01

    A business Spanish curriculum that presents the full spectrum of general and specialized areas--including management, banking, finance, marketing and advertising--might seem ambitious for a single course. A course that aims to present the full picture would seem to impose an undue burden on memory and retention of the content. By emphasizing…

  4. 20 CFR 902.4 - Access to records.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... regular business hours on regular business days at the office of the Executive Director. Every request for... without undue difficulty. (c) Fees. A fee at the rate of $5.00 per hour or fraction thereof or the time... provided without charge or at a reduced charge where the Chairman determines that waiver or reduction of...

  5. Measuring forest-fire danger in northern Idaho

    Treesearch

    H. T. Gisborne

    1928-01-01

    In most of the forest regions of the United States the fire problem is the greatest forest problem. Wasteful methods of logging and lumbering may result in the loss of a large proportion of the remaining forest growth, but the land will usually produce a new crop of timber without undue delay, unless fire occurs.

  6. Influence of Peripheral and Motivational Cues on Rigid-Flexible Functioning: Perceptual, Behavioral, and Cognitive Aspects

    ERIC Educational Resources Information Center

    Cretenet, Joel; Dru, Vincent

    2009-01-01

    Recent research has shown that performing approach versus avoidance behaviors (arm flexion vs. extension) effectively influences cognitive functioning. In another area, lateralized peripheral activations (left vs. right side) of the motivational systems of approach versus avoidance were linked to various performances in cognitive tasks. By…

  7. Stuck in the spin cycle: Avoidance and intrusions following breast cancer diagnosis.

    PubMed

    Bauer, Margaret R; Wiley, Joshua F; Weihs, Karen L; Stanton, Annette L

    2017-09-01

    Theories and research regarding cognitive and emotional processing during the experience of profound stressors suggest that the presence of intrusive thoughts and feelings predicts greater use of avoidance and that the use of avoidance paradoxically predicts more intrusions. However, empirical investigations of their purported bidirectional relationship are limited. This study presents a longitudinal investigation of the reciprocal relationship between intrusions and avoidance coping over a 6-month period in the year following breast cancer diagnosis. Breast cancer patients (N = 460) completed measures of cancer-related intrusions and avoidance at study entry, 3 months, and 6 months later (i.e., an average of 2, 5, and 8 months after diagnosis, respectively). Cross-lagged panel analyses revealed that intrusive thoughts, feelings, and images at study entry predicted greater avoidance 3 months later, and avoidance coping at study entry predicted intrusions 3 months later, controlling for the stability of intrusions and avoidance as well as time since diagnosis. Findings were not statistically significant for avoidance predicting intrusions, or vice versa, between the 3-month and the 6-month assessment period, during which they declined. These findings provide empirical support for the theoretical contention that avoidance and intrusive thoughts and emotions reciprocally influence one another following stressful events. Additionally, in the months shortly after breast cancer diagnosis, intrusions and avoidance are positively related. However, the relationships attenuate over time, which could indicate resolved cognitive and emotional processing of the cancer experience. Statement of contribution What is already known on this subject? Following stressful life events, individuals often experience intrusive thoughts and feelings related to the event and they report avoidance of such reminders. Many studies demonstrate that greater intrusions predict more subsequent use of avoidance coping, and other studies show that greater use of avoidance predicts more intrusions. Their reciprocal relation has not been examined, however. What does this study add? This is the first examination of the concurrent, reciprocal influence of intrusions and avoidance. Findings suggest that accounting for the bidirectional influence of avoidance and intrusions best estimates hypothesized models. Higher intrusions and avoidance predicted each other for the first 3 months after study entry, but the relationship diminished 6 months after study entry, perhaps due to productive mental processing of the stress of breast cancer diagnosis and treatment. © 2017 The British Psychological Society.

  8. Optimism Moderates the Influence of Pain Catastrophizing on Shoulder Pain Outcome: A Longitudinal Analysis.

    PubMed

    Coronado, Rogelio A; Simon, Corey B; Lentz, Trevor A; Gay, Charles W; Mackie, Lauren N; George, Steven Z

    2017-01-01

    Study Design Secondary analysis of prospectively collected data. Background An abundance of evidence has highlighted the influence of pain catastrophizing and fear avoidance on clinical outcomes. Less is known about the interaction of positive psychological resources with these pain-associated distress factors. Objective To assess whether optimism moderates the influence of pain catastrophizing and fear avoidance on 3-month clinical outcomes in patients with shoulder pain. Methods Data from 63 individuals with shoulder pain (mean ± SD age, 38.8 ± 14.9 years; 30 female) were examined. Demographic, psychological, and clinical characteristics were obtained at baseline. Validated measures were used to assess optimism (Life Orientation Test-Revised), pain catastrophizing (Pain Catastrophizing Scale), fear avoidance (Fear-Avoidance Beliefs Questionnaire physical activity subscale), shoulder pain intensity (Brief Pain Inventory), and shoulder function (Pennsylvania Shoulder Score function subscale). Shoulder pain and function were reassessed at 3 months. Regression models assessed the influence of (1) pain catastrophizing and optimism and (2) fear avoidance and optimism. The final multivariable models controlled for factors of age, sex, education, and baseline scores, and included 3-month pain intensity and function as separate dependent variables. Results Shoulder pain (mean difference, -1.6; 95% confidence interval [CI]: -2.1, -1.2) and function (mean difference, 2.4; 95% CI: 0.3, 4.4) improved over 3 months. In multivariable analyses, there was an interaction between pain catastrophizing and optimism (β = 0.19; 95% CI: 0.02, 0.35) for predicting 3-month shoulder function (F = 16.8, R 2 = 0.69, P<.001), but not pain (P = .213). Further examination of the interaction with the Johnson-Neyman technique showed that higher levels of optimism lessened the influence of pain catastrophizing on function. There was no evidence of significant moderation of fear-avoidance beliefs for 3-month shoulder pain (P = .090) or function (P = .092). Conclusion Optimism decreased the negative influence of pain catastrophizing on shoulder function, but not pain intensity. Optimism did not alter the influence of fear-avoidance beliefs on these outcomes. Level of Evidence Prognosis, level 2b. J Orthop Sports Phys Ther 2017;47(1):21-30. Epub 5 Nov 2016. doi:10.2519/jospt.2017.7068.

  9. Interpersonal Influence Strategies Applied to Sexual Decision-Making of Adolescents.

    ERIC Educational Resources Information Center

    Falbo, Toni; Eisen, Marvin

    Little is known about the power strategies adolescents view as effective in influencing an intimate partner to have or avoid having sexual intercourse. These strategies were examined in a pretest survey of 203 adolescents who reported their agreement or disagreement with strategies used to have protected sex or to avoid having sex with a…

  10. Human factors considerations in designing for infection prevention and control in neonatal care - findings from a pre-design inquiry.

    PubMed

    Trudel, Chantal; Cobb, Sue; Momtahan, Kathryn; Brintnell, Janet; Mitchell, Ann

    2018-01-01

    Qualitative data collection methods drawn from the early stages of human-centred design frameworks combined with thematic analysis were used to develop an understanding of infection prevention practice within an existing neonatal intensive care unit. Findings were used to generate a framework of understanding which in turn helped inform a baseline approach for future research and design development. The study revealed that a lack of clarity between infection transmission zones and a lack of design attributes needed to uphold infection prevention measures may be undermining healthcare workers' understanding and application of good practice. The issue may be further complicated by well-intentioned behavioural attitudes to meeting work objectives; undue influences from spatial constraints; the influence of inadvertent and excessive touch-based interactions; physical and/or cognitive exertion to maintain transmission barriers; and the impact of expanding job design and increased workload to supplement for lack of effective barriers. Practitioner Summary: Despite high hand hygiene compliance within a neonatal intensive care unit, healthcare workers expressed concerns about the unit design and infection prevention practice. Early inquiry methods from human-centred design and thematic analysis helped develop a framework to understand how design can be used to aid infection prevention.

  11. Cancer patient decision making related to clinical trial participation: an integrative review with implications for patients' relational autonomy.

    PubMed

    Bell, Jennifer A H; Balneaves, Lynda G

    2015-04-01

    Oncology clinical trials are necessary for the improvement of patient care as they have the ability to confirm the efficacy and safety of novel cancer treatments and in so doing, contribute to a solid evidence base on which practitioners and patients can make informed treatment decisions. However, only 3-5 % of adult cancer patients enroll in clinical trials. Lack of participation compromises the success of clinical trials and squanders an opportunity for improving patient outcomes. This literature review summarizes the factors and contexts that influence cancer patient decision making related to clinical trial participation. An integrative review was undertaken within PubMed, CINAHL, and EMBASE databases for articles written between 1995 and 2012 and archived under relevant keywords. Articles selected were data-based, written in English, and limited to adult cancer patients. In the 51 articles reviewed, three main types of factors were identified that influence cancer patients' decision making about participation in clinical trials: personal, social, and system factors. Subthemes included patients' trust in their physician and the research process, undue influence within the patient-physician relationship, and systemic social inequalities. How these factors interact and influence patients' decision-making process and relational autonomy, however, is insufficiently understood. Future research is needed to further elucidate the sociopolitical barriers and facilitators of clinical trial participation and to enhance ethical practice within clinical trial enrolment. This research will inform targeted education and support interventions to foster patients' relational autonomy in the decision-making process and potentially improve clinical trial participation rates.

  12. Undue industry influences that distort healthcare research, strategy, expenditure and practice: a review.

    PubMed

    Stamatakis, Emmanuel; Weiler, Richard; Ioannidis, John P A

    2013-05-01

    Expenditure on industry products (mostly drugs and devices) has spiraled over the last 15 years and accounts for substantial part of healthcare expenditure. The enormous financial interests involved in the development and marketing of drugs and devices may have given excessive power to these industries to influence medical research, policy, and practice. Review of the literature and analysis of the multiple pathways through which the industry has directly or indirectly infiltrated the broader healthcare systems. We present the analysis of the industry influences at the following levels: (i) evidence base production, (ii) evidence synthesis, (iii) understanding of safety and harms issues, (iv) cost-effectiveness evaluation, (v) clinical practice guidelines formation, (vi) healthcare professional education, (vii) healthcare practice, (viii) healthcare consumer's decisions. We located abundance of consistent evidence demonstrating that the industry has created means to intervene in all steps of the processes that determine healthcare research, strategy, expenditure, practice and education. As a result of these interferences, the benefits of drugs and other products are often exaggerated and their potential harms are downplayed, and clinical guidelines, medical practice, and healthcare expenditure decisions are biased. To serve its interests, the industry masterfully influences evidence base production, evidence synthesis, understanding of harms issues, cost-effectiveness evaluations, clinical practice guidelines and healthcare professional education and also exerts direct influences on professional decisions and health consumers. There is an urgent need for regulation and other action towards redefining the mission of medicine towards a more objective and patient-, population- and society-benefit direction that is free from conflict of interests. © 2013 Stichting European Society for Clinical Investigation Journal Foundation. Published by Blackwell Publishing Ltd.

  13. Designing and Building to ``Impossible'' Tolerances for Vibration Sensitive Equipment

    NASA Astrophysics Data System (ADS)

    Hertlein, Bernard H.

    2003-03-01

    As the precision and production capabilities of modern machines and factories increase, our expectations of them rise commensurately. Facility designers and engineers find themselves increasingly involved with measurement needs and design tolerances that were almost unthinkable a few years ago. An area of expertise that demonstrates this very clearly is the field of vibration measurement and control. Magnetic Resonance Imaging, Semiconductor manufacturing, micro-machining, surgical microscopes — These are just a few examples of equipment or techniques that need an extremely stable vibration environment. The challenge to architects, engineers and contractors is to provide that level of stability without undue cost or sacrificing the aesthetics and practicality of a structure. In addition, many facilities have run out of expansion room, so the design is often hampered by the need to reuse all or part of an existing structure, or to site vibration-sensitive equipment close to an existing vibration source. High resolution measurements and nondestructive testing techniques have proven to be invaluable additions to the engineer's toolbox in meeting these challenges. The author summarizes developments in this field over the last fifteen years or so, and lists some common errors of design and construction that can cost a lot of money in retrofit if missed, but can easily be avoided with a little foresight, an appropriate testing program and a carefully thought out checklist.

  14. Classification and management of asbestos-containing waste: European legislation and the Italian experience.

    PubMed

    Paglietti, Federica; Malinconico, Sergio; della Staffa, Beatrice Conestabile; Bellagamba, Sergio; De Simone, Paolo

    2016-04-01

    Production of a new classification of Asbestos Containing Products (ACPs), materials (ACM) and Asbestos Containing Waste (ACW), in addition to a correct identification of landfills where ACW should be disposed of in Europe. Analysis of the European and Italian legislation, study of waste classification and management in the main European countries, data analysis of mapping of Italian landfills and quantification of ACW disposed there. Classification according to unique criteria (physical state, substances with which asbestos minerals have been blended, function of the asbestos, etc.). Highlights of cases of incorrect management of ACW in Europe, specifying the Italian ones. Considering the significant inconsistencies between the European and national regulations and the actual implementation of those regulations, this paper provide some precise indications for the proper assignment to ACW of the European Waste Catalogue (EWC) codes. Lastly, suitable types of landfills at which ACW should be disposed of have been identified, in order to assisting the persons involved in ACW management to avoid undue exposition and their improper disposal. This study reports a useful manual for classifying worldwide ACPs based on their physical state and considering the substances with which the asbestos minerals have been blended. Moreover several clear tables allow the asbestos remediation and waste management operators to suitably classify and dispose of ACW. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Diagnostic characteristics of sinonasal organizing hematomas: avoiding misdiagnosis.

    PubMed

    Wu, Arthur W; Ting, Jonathan Y; Borgie, Roderick C; Busaba, Nicolas Y; Sadow, Peter M; Juliano, Amy F; Gray, Stacey T; Holbrook, Eric H

    2013-07-01

    Organizing hematomas of the paranasal sinuses are diagnostic dilemmas clinically and radiographically, mimicking benign or malignant neoplastic processes and causing patients and clinicians undue worry regarding these diagnoses. Diagnostic criteria for correctly identifying these lesions are not well known. A retrospective case series of 7 patients with sinonasal organizing hematoma was studied. Radiographic imaging, clinical characteristics, and pathology were reviewed for new insights. Three patients presented with a primary complaint of epistaxis, 4 had masses visible on nasal endoscopy, and 2 had vascular malformations or small hemangiomas adjacent to the mass found on final pathology. Biopsy of these masses were consistently nondiagnostic prior to complete resection. The most diagnostic findings were "shells" of T2 hypointensity on magnetic resonance imaging (MRI) surrounding the lobules of each of the masses. These correspond to rims of fibrosis at the periphery of the lobules on pathology. Areas of fresh hemorrhage are located at the center of these lobules. Sinonasal organizing hematomas are rare lesions of the paranasal sinuses whose clinical characteristics lead to misdiagnoses of benign or malignant neoplasms. Endoscopy, preoperative biopsy, and computed tomography (CT) imaging do not lend helpful information in differentiating these lesions from more worrisome neoplastic processes. However, MRI can lead to positive diagnosis by recognizing the distinct outer rims of T2 hypointensity typically seen in these lesions. © 2013 ARS-AAOA, LLC.

  16. Challenges to complete and useful data sharing.

    PubMed

    Mbuagbaw, Lawrence; Foster, Gary; Cheng, Ji; Thabane, Lehana

    2017-02-14

    Data sharing from clinical trials is one way of promoting fair and transparent conduct of clinical trials. It would maximise the use of data and permit the exploration of additional hypotheses. On the other hand, the quality of secondary analyses cannot always be ascertained, and it may be unfair to investigators who have expended resources to collect data to bear the additional burden of sharing. As the discussion on the best modalities of sharing data evolves, some of the practical issues that may arise need to be addressed. In this paper, we discuss issues which impede the use of data even when sharing should be possible: (1) multicentre studies requiring consent from all the investigators in each centre; (2) remote access platforms with software limitations and Internet requirements; (3) on-site data analysis when data cannot be moved; (4) governing bodies for data generated in one jurisdiction and analysed in another; (5) using programmatic data collected as part of routine care; (6) data collected in multiple languages; (7) poor data quality. We believe these issues apply to all primary data and cause undue difficulties in conducting analysis even when there is some willingness to share. They can be avoided by anticipating the possibility of sharing any clinical data and pre-emptively removing or addressing restrictions that limit complete sharing. These issues should be part of the data sharing discussion.

  17. Improving Efficiency and Quality of the Children's ASD Diagnostic Pathway: Lessons Learned from Practice

    ERIC Educational Resources Information Center

    Rutherford, Marion; Burns, Morag; Gray, Duncan; Bremner, Lynne; Clegg, Sarah; Russell, Lucy; Smith, Charlie; O'Hare, Anne

    2018-01-01

    The 'autism diagnosis crisis' and long waiting times for assessment are as yet unresolved, leading to undue stress and limiting access to effective support. There is therefore a significant need for evidence to support practitioners in the development of efficient services, delivering acceptable waiting times and effectively meeting guideline…

  18. 29 CFR 1605.2 - Reasonable accommodation without undue hardship as required by section 701(j) of title VII of the...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION... address other obligations under title VII not to discriminate on grounds of religion, nor other provisions... to discrimination prohibited by title VII on the bases of race, color, sex, and national origin also...

  19. 29 CFR 1605.2 - Reasonable accommodation without undue hardship as required by section 701(j) of title VII of the...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION... address other obligations under title VII not to discriminate on grounds of religion, nor other provisions... to discrimination prohibited by title VII on the bases of race, color, sex, and national origin also...

  20. 29 CFR 1605.2 - Reasonable accommodation without undue hardship as required by section 701(j) of title VII of the...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION... address other obligations under title VII not to discriminate on grounds of religion, nor other provisions... to discrimination prohibited by title VII on the bases of race, color, sex, and national origin also...

  1. 29 CFR 1605.2 - Reasonable accommodation without undue hardship as required by section 701(j) of title VII of the...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Regulations Relating to Labor (Continued) EQUAL EMPLOYMENT OPPORTUNITY COMMISSION GUIDELINES ON DISCRIMINATION... address other obligations under title VII not to discriminate on grounds of religion, nor other provisions... to discrimination prohibited by title VII on the bases of race, color, sex, and national origin also...

  2. Anatomy Adventure: A Board Game for Enhancing Understanding of Anatomy

    ERIC Educational Resources Information Center

    Anyanwu, Emeka G.

    2014-01-01

    Certain negative factors such as fear, loss of concentration and interest in the course, lack of confidence, and undue stress have been associated with the study of anatomy. These are factors most often provoked by the unusually large curriculum, nature of the course, and the psychosocial impact of dissection. As a palliative measure, Anatomy…

  3. A Review of Parliamentary Privilege with an Approach to Iranian Legal System

    ERIC Educational Resources Information Center

    Habibzadeh, Mohammad Ja'far; Modjab, Seyed Doraid mousavi

    2006-01-01

    The necessity of immunity of parliament and its Members has led to determine and assure particular privilege in the Constitutions or ordinary laws in the great majority of countries. This legal institution is to provide freedom of speech and to maintain the independence of representatives in the exercise of their duties without undue interference…

  4. 12 CFR 32.7 - Residential real estate loans, small business loans, and small farm loans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... total outstanding amount of a national bank's loans and extensions of credit to one borrower made under... surplus. (5) The total outstanding amount of a national bank's loans and extensions of credit to all of... concerns about credit quality, undue concentrations in the bank's portfolio of residential real estate...

  5. 75 FR 53985 - Arizona Public Service Company, et al., Palo Verde Nuclear Generating Station, Unit 3; Temporary...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-02

    ... are authorized by law, will not present an undue risk to public health or safety, and are consistent... Public Health and Safety The underlying purpose of 10 CFR 50.46 is to establish acceptance criteria for... (LOCA) and non-LOCA criteria, mechanical design, thermal hydraulics, seismic, core physics, and...

  6. IS YOUR DISTRICT READY TO START A JUNIOR COLLEGE.

    ERIC Educational Resources Information Center

    PATTERSON, DOW

    TO DETERMINE IF A DISTRICT IS READY TO ESTABLISH A JUNIOR COLLEGE, CERTAIN QUESTIONS MUST BE ANSWERED--(1) ARE THERE ENOUGH HIGH SCHOOL GRADUATES TO WARRANT THE PROGRAM WITHOUT UNDUE TAXATION. (2) WILL THE COLLEGE BE ABLE TO OFFER THE USUAL PROGRAMS OF TRANSFER, VOCATIONAL TRAINING, GUIDANCE, AND GENERAL EDUCATION. (3) SHOULD IT BE AN EXTENSION OF…

  7. 30 CFR 57.12083 - Support of power cables in shafts and boreholes.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Support of power cables in shafts and boreholes... NONMETAL MINES Electricity Underground Only § 57.12083 Support of power cables in shafts and boreholes. Power cables in shafts and boreholes shall be fastened securely in such a manner as to prevent undue...

  8. 30 CFR 57.12083 - Support of power cables in shafts and boreholes.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Support of power cables in shafts and boreholes... NONMETAL MINES Electricity Underground Only § 57.12083 Support of power cables in shafts and boreholes. Power cables in shafts and boreholes shall be fastened securely in such a manner as to prevent undue...

  9. 30 CFR 57.12083 - Support of power cables in shafts and boreholes.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Support of power cables in shafts and boreholes... NONMETAL MINES Electricity Underground Only § 57.12083 Support of power cables in shafts and boreholes. Power cables in shafts and boreholes shall be fastened securely in such a manner as to prevent undue...

  10. 30 CFR 57.12083 - Support of power cables in shafts and boreholes.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Support of power cables in shafts and boreholes... NONMETAL MINES Electricity Underground Only § 57.12083 Support of power cables in shafts and boreholes. Power cables in shafts and boreholes shall be fastened securely in such a manner as to prevent undue...

  11. 30 CFR 57.12083 - Support of power cables in shafts and boreholes.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Support of power cables in shafts and boreholes... NONMETAL MINES Electricity Underground Only § 57.12083 Support of power cables in shafts and boreholes. Power cables in shafts and boreholes shall be fastened securely in such a manner as to prevent undue...

  12. Analysis of variance calculations for irregular experiments

    Treesearch

    Jonathan W. Wright

    1977-01-01

    Irregular experiments may be more useful than much smaller regular experiments and can be analyzed statistically without undue expenditure of time. For a few missing plots, standard methods of calculating missing-plot values can be used. For more missing plots (up to 10 percent), seedlot means or randomly chosen plot means of the same seedlot can be substituted for...

  13. 43 CFR 3809.415 - How do I prevent unnecessary or undue degradation while conducting operations on public lands?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... protection and protection of cultural resources; (b) Assuring that your operations are “reasonably incident... (c) Attaining the stated level of protection or reclamation required by specific laws in areas such as the California Desert Conservation Area, Wild and Scenic Rivers, BLM-administered portions of the...

  14. 41 CFR Appendix A to Part 60 - 300-Guidelines on a Contractor's Duty To Provide Reasonable Accommodation

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... privileges of employment as are enjoyed by employees without disabilities. 4. The term “undue hardship...)), the Job Accommodation Network (JAN) operated by the Office of Disability Employment Policy in the U.S... privileges of employment as are enjoyed by employees who do not have disabilities. 8. Another of the...

  15. Going Round in Circles: Temporal Discontinuity as a Gross Impediment to Effective Innovation in Education and Training

    ERIC Educational Resources Information Center

    Oates, Tim

    2008-01-01

    The analysis presented in this paper offers different examples of how timing issues have adversely affected a series of innovations in education and training. The term "'temporal discontinuity" is used since the problems cannot simply be characterised as "'undue rushing" or "impatience on the part of policy makers."…

  16. Hospital Selective Contracting without Consumer Choice: What Can We Learn from Medi-Cal?

    ERIC Educational Resources Information Center

    Bamezai, Anil; Melnick, Glenn A.; Mann, Joyce M.; Zwanziger, Jack

    2003-01-01

    In the selective contracting era, consumer choice has generally been absent in most state Medicaid programs, including California's (called Medi-Cal). In a setting where beneficiary exit is not a threat, a large payer may have both the incentives and the ability to exercise undue market power, potentially exposing an already vulnerable population…

  17. Position And Force Control For Multiple-Arm Robots

    NASA Technical Reports Server (NTRS)

    Hayati, Samad A.

    1988-01-01

    Number of arms increased without introducing undue complexity. Strategy and computer architecture developed for simultaneous control of positions of number of robot arms manipulating same object and of forces and torques that arms exert on object. Scheme enables coordinated manipulation of object, causing it to move along assigned trajectory and be subjected to assigned internal forces and torques.

  18. 75 FR 60411 - Request for Comment on Options for a Proposed Exemptive Order Relating to the Trading and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... in the precious metals markets. \\28\\ See http://www.sec.gov/Archives/edgar/data/1459862... efficient exposure to commodity market price movements.\\4\\ These Precious Metal Commodity-Based ETFs have... conditions to the exemption orders) and that novel products may be introduced without undue delay for market...

  19. Language Teaching in the Post-Nuclear Age.

    ERIC Educational Resources Information Center

    Schneider, Eugene F.

    In recent times there has been undue emphasis placed on the utilitarian byproducts of language study: the kinds of positions open for language majors, the practical purposes to which languages may be put, and job openings in the areas of translation, diplomacy, and commerce. These motives for the study of a language are commendable, but they do…

  20. 78 FR 8685 - Noise Exposure Map Notice; Receipt of Noise Compatibility Program and Request for Review: Tweed...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... of this program for public review and comment. Under Section 103 of Title I of the Aviation Safety... proposed measures may reduce the level of aviation safety, create an undue burden on interstate or foreign... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Noise Exposure Map Notice; Receipt of...

  1. 76 FR 23797 - Notice of Proposed Information Collection Requests

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-28

    ... consultation to the extent that public participation in the approval process would defeat the purpose of the... Race to the Top grantees and subgrantees as soon as possible to inform decision-making for the second... undue burden on the LEAs and on the State. During the process of developing the Race to the Top Annual...

  2. Understanding Time: A Research Based Framework

    ERIC Educational Resources Information Center

    Thomas, Margaret; Clarke, Doug; McDonough, Andrea; Clarkson, Philip

    2016-01-01

    Time is crucial in our society. However, it would appear that there is limited research on the learning and teaching of time. Curricula appear to place an undue emphasis on the reading of time measuring tools. We argue that key ideas of succession, duration, and measurement should be central to learning about time. Drawing upon available research,…

  3. 76 FR 63537 - Mandatory Electronic Filing for Agencies and Attorneys at Washington Regional Office and Denver...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... believes e-filing would create an undue burden may request an exemption from the administrative [email protected] . SUPPLEMENTARY INFORMATION: 1. History of MSPB's E-Filing Initiative On February 26, 2008, MSPB issued final regulations at 5 CFR parts 1201, 1203, 1208, and 1209 governing e-filing. 73 FR 10127...

  4. 10 CFR 72.54 - Expiration and termination of licenses and decommissioning of sites and separate buildings or...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... conduct of decommissioning operations and presents no undue risk from radiation to the public health and... final radiation survey; and (5) An updated detailed cost estimate for the chosen alternative for... accordance with the regulations in this chapter, and will not be inimical to the common defense and security...

  5. 75 FR 10263 - Notice of Public Information Collections Being Reviewed by the Federal Communications Commission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-05

    ... programming (which, as defined in this R&O, includes exclusive contracts, discrimination, and undue or... terrestrially delivered, cable-affiliated programming considered under the rules adopted in the R&O must submit... Sections 4(i), 303(r) and 628 of the Communications Act of 1934, as amended. Total Annual Burden: 20,960...

  6. Building a Sustainable Life Science Information Literacy Program Using the Train-the-Trainer Model

    ERIC Educational Resources Information Center

    Hartman, Patricia; Newhouse, Renae; Perry, Valerie

    2014-01-01

    The train-the-trainer model has great potential for expanding information literacy programs without placing undue burden on already overextended librarians; it is surprisingly underused in academic libraries. At the University of Kentucky, we employed this model to create a new information literacy program in an introductory biology lab. We…

  7. 5 CFR 2423.31 - Powers and duties of the Administrative Law Judge at the hearing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... review will cause undue harm to a party or the public. (2) If the motion is granted, the Judge or... Law Judge at the hearing. 2423.31 Section 2423.31 Administrative Personnel FEDERAL LABOR RELATIONS AUTHORITY, GENERAL COUNSEL OF THE FEDERAL LABOR RELATIONS AUTHORITY AND FEDERAL SERVICE IMPASSES PANEL...

  8. Prescribed burning with spot fires in the Georgia Coastal Plain

    Treesearch

    R. W. Johansen

    1984-01-01

    The use of prescribed fire in the management of pine forests is common throughout much of the South, but one recurring problem that worries the forest landowner is not having enough suitable burning weather to satisfactorily complete all scheduled fires. Being able to burn areas considerably faster, without causing undue damage, could be a solution.

  9. 78 FR 75379 - Entergy Operations, Inc.; Combined License Application for Grand Gulf Unit 3; Exemption From the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-11

    ... accidents are increased. Therefore, there is no undue risk to public health and safety. Plant construction... at this time. Based on the nature of the requested exemption as described above, no new accident... a license decision is made, the probability of postulated accidents is not increased. Additionally...

  10. 26 CFR 35a.3406-2 - Imposition of backup withholding for notified payee underreporting of reportable interest or...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... withholding causes undue hardship include, but are not limited to, the following: (i) Whether estimated tax..., and (2) The payments of estimated tax which are considered payments on account of such taxes. (C... Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) EMPLOYMENT TAXES AND COLLECTION...

  11. Does habitual body avoidance and checking behavior influence the decrease of negative emotions during body exposure in eating disorders?

    PubMed

    Vocks, Silja; Kosfelder, Joachim; Wucherer, Maike; Wächter, Alexandra

    2008-07-01

    The aim of the present study was to assess whether habitual body avoidance and body-checking behavior influences the decrease of negative emotions during body exposure. Twenty-one eating-disordered female participants completed the Body Image Avoidance Questionnaire and the Body Checking Questionnaire. On another day, a 40-min body exposure session was conducted under standardized conditions. Every 10 min, negative emotions were assessed. It was shown that the extent of decrease in negative emotions during the body exposure session could be predicted by a lower degree of body checking. Results indicate that habitual checking behavior seems to negatively influence the effect of body exposure. Therefore, an adaptation of body exposure to patients with a higher degree of body-checking behavior might be promising.

  12. [Influence of activation and blockade of NMDA receptors on extinction of passive avoidance response in mice with different levels of anxiety].

    PubMed

    Tomilenko, R A; Dubrovina, N I

    2006-03-01

    Influence of agonist (D-cycloserine) and antagonist (dizocilpine) N-methyl-D-aspartate receptors on learning and extinction of passive avoidance response in medium-, high-, and low-anxious mice was studied. In medium-anxious mice, D-cycloserine (30 mg/kg) although not changing learning accelerated development of extinction, whereas dizocilpine (0.15 mg/kg), while impairing passive avoidance learning, detained the extinction. In high-anxious mice with good retrieval of memory trace and absence of extinction, D-cycloserine was ineffective, whereas dizocilpine reduced learning and promoted retention of memory trace retrieval at the generated level on extinction. In low-anxious mice, D-cycloserine impaired learning and accelerated extinction, whereas dizocilpine completely blocked learning and retention of passive avoidance response.

  13. Maternal Modeling and the Acquisition of Fear and Avoidance in Toddlers: Influence of Stimulus Preparedness and Child Temperament

    ERIC Educational Resources Information Center

    Dubi, Kathrin; Rapee, Ronald M.; Emerton, Jane L.; Schniering, Carolyn A.

    2008-01-01

    The aim of the present study was to investigate the influence of maternal modeling on the acquisition of fear and avoidance towards fear-relevant and fear-irrelevant, novel stimuli in a sample of 71 toddlers. Children were shown a rubber snake or spider (fear-relevant objects) and a rubber mushroom or flower (fear-irrelevant objects), which were…

  14. Potentiation of the early visual response to learned danger signals in adults and adolescents

    PubMed Central

    Howsley, Philippa; Jordan, Jeff; Johnston, Pat

    2015-01-01

    The reinforcing effects of aversive outcomes on avoidance behaviour are well established. However, their influence on perceptual processes is less well explored, especially during the transition from adolescence to adulthood. Using electroencephalography, we examined whether learning to actively or passively avoid harm can modulate early visual responses in adolescents and adults. The task included two avoidance conditions, active and passive, where two different warning stimuli predicted the imminent, but avoidable, presentation of an aversive tone. To avoid the aversive outcome, participants had to learn to emit an action (active avoidance) for one of the warning stimuli and omit an action for the other (passive avoidance). Both adults and adolescents performed the task with a high degree of accuracy. For both adolescents and adults, increased N170 event-related potential amplitudes were found for both the active and the passive warning stimuli compared with control conditions. Moreover, the potentiation of the N170 to the warning stimuli was stable and long lasting. Developmental differences were also observed; adolescents showed greater potentiation of the N170 component to danger signals. These findings demonstrate, for the first time, that learned danger signals in an instrumental avoidance task can influence early visual sensory processes in both adults and adolescents. PMID:24652856

  15. [Familial transmission of depression: the importance of harm avoidance].

    PubMed

    Ulrich, I; Stopsack, M; Spitzer, C; Grabe, H-J; Freyberger, H J; Barnow, S

    2011-09-01

    Previous research about the aetiology of depression has analysed how depression-associated personality traits influence familial transmission. Using the community-based sample of the Greifswald Family Study, we investigated longitudinally to which extent the temperament factor harm avoidance influences the correlation between parent's depression and the depression of their offspring (with regard to possible sex differences). To test this familial transmission a structural equation model was conducted with the data of 193 children (mean age 19.5, SD=2.41) and their biological parents. Depression was assessed with structured clinical interviews, and harm avoidance with Cloninger's Temperament and Character Inventory (TCI, JTCI). The harm avoidance scores of the mothers were significantly correlated with the harm avoidance scores of their children, but the correlation of the father's and children's scores did not reach significance. The extent of harm avoidance at the first assessment of the 14-year-old children predicted depression 5 years later. These results indicate the importance of personality as a vulnerability marker for developing affective disorders. The results are discussed with respect to prevention programmes for children and parents with depression, especially if they exhibit strongly avoidant or anxious behaviour.

  16. 75 FR 24755 - DTE ENERGY; Enrico Fermi Atomic Power Plant Unit 1; Exemption From Certain Low-Level Waste...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 50-16; NRC-2009-0073] DTE ENERGY; Enrico Fermi Atomic... License No. DPR-9 issued for Enrico Fermi Atomic Power Plant, Unit 1 (Fermi-1), located in Monroe County... undue hazard to life or property. There are no provisions in the Atomic Energy Act (or in any other...

  17. 77 FR 34249 - Notice of Final Revision to Guidance for the Use of Binding Arbitration Under the Administrative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-11

    ... was procured by corruption, fraud, or undue means; where there was arbitrator partiality, corruption.... Questions and Answers on FMCSA's Use of Binding Arbitration Issue 1: For what types of cases will FMCSA be... proceeding in advance of expenses being incurred.) 8. The date the arbitration will begin. 9. The types of...

  18. 25 CFR 103.36 - What options and remedies does the lender have if the borrower defaults on the loan?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...'s behalf during the default, if doing so is reasonably necessary to ensure that loan recovery... perform the duty that jeopardizes loan recovery, including by undue delay in making the payment or... delivery service (signature of recipient required) within 90 calendar days of the default to select one of...

  19. 46 CFR 160.044-4 - Inspection and tests.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Inspection and tests. (a) Capacity. The bilge pump being tested shall be set up over a source of water for... water measured. The amount of water discharged shall not be less than that required by § 160.044-2(b... slippage of the lever around the shaft, nor any evidence of permanent set or undue stress in any part of...

  20. 46 CFR 160.044-4 - Inspection and tests.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Inspection and tests. (a) Capacity. The bilge pump being tested shall be set up over a source of water for... water measured. The amount of water discharged shall not be less than that required by § 160.044-2(b... slippage of the lever around the shaft, nor any evidence of permanent set or undue stress in any part of...

  1. 29 CFR 18.28 - Continuances.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... cases of prior judicial commitments or undue hardship, or a showing of other good cause. (b) Time limit... shall be in writing. At least 3″ x 3 1/2″ of blank space shall be provided on the last page of the... 29 Labor 1 2011-07-01 2011-07-01 false Continuances. 18.28 Section 18.28 Labor Office of the...

  2. 29 CFR 18.28 - Continuances.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... cases of prior judicial commitments or undue hardship, or a showing of other good cause. (b) Time limit... shall be in writing. At least 3″x31/2″ of blank space shall be provided on the last page of the motion... 29 Labor 1 2010-07-01 2010-07-01 true Continuances. 18.28 Section 18.28 Labor Office of the...

  3. 30 CFR 285.617 - What activities require a revision to my SAP, and when will MMS approve the revision?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What activities require a revision to my SAP, and when will MMS approve the revision? 285.617 Section 285.617 Mineral Resources MINERALS MANAGEMENT...: (1) Designed not to cause undue harm or damage to natural resources; life (including human and...

  4. 26 CFR 301.6112-1 - Material advisors of reportable transactions must keep lists of advisees, etc.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... enables the IRS to determine without undue delay or difficulty the information required in paragraph (b)(3... the material advisor is a party; and (B) Copies of any additional written materials, including tax... must, upon written request by the IRS, make each component of the list described in paragraph (b)(3) of...

  5. 26 CFR 301.6112-1 - Material advisors of reportable transactions must keep lists of advisees, etc.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... maintained in a form that enables the IRS to determine without undue delay or difficulty the information...) of this section) to which the material advisor is a party; and (B) Copies of any additional written... written request by the IRS, make each component of the list described in paragraph (b)(3) of this section...

  6. 26 CFR 301.6112-1 - Material advisors of reportable transactions must keep lists of advisees, etc.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... enables the IRS to determine without undue delay or difficulty the information required in paragraph (b)(3... the material advisor is a party; and (B) Copies of any additional written materials, including tax... must, upon written request by the IRS, make each component of the list described in paragraph (b)(3) of...

  7. 26 CFR 301.6112-1 - Material advisors of reportable transactions must keep lists of advisees, etc.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... enables the IRS to determine without undue delay or difficulty the information required in paragraph (b)(3... the material advisor is a party; and (B) Copies of any additional written materials, including tax... must, upon written request by the IRS, make each component of the list described in paragraph (b)(3) of...

  8. 30 CFR 285.655 - What activities require a revision to my GAP, and when will MMS approve the revision?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: (1) Designed not to cause undue harm or damage to natural resources; life (including human and... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What activities require a revision to my GAP, and when will MMS approve the revision? 285.655 Section 285.655 Mineral Resources MINERALS MANAGEMENT...

  9. 30 CFR 285.634 - What activities require a revision to my COP, and when will MMS approve the revision?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...: (1) Designed not to cause undue harm or damage to natural resources; life (including human and... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What activities require a revision to my COP, and when will MMS approve the revision? 285.634 Section 285.634 Mineral Resources MINERALS MANAGEMENT...

  10. Defining the Burden and Measuring Resource Utilization (Part 1 of a Working Caregivers Feature)

    ERIC Educational Resources Information Center

    Shadden, Barbara; Powers, Melissa; DiBrezzo, Ro

    2004-01-01

    An increasing number of Americans today are finding themselves in the position of being both a full-time employee and a part- or full-time caregiver for an adult relative. Often, their job responsibilities and their caregiving duties collide, creating undue stress and costing both the employer and the employee hundreds of thousands of dollars in…

  11. Bioethical Issues in Providing Financial Incentives to Research Participants

    PubMed Central

    Resnik, David B.

    2015-01-01

    Offering research subjects financial incentives for their participation is a common practice that boosts recruitment but also raises ethical concerns, such as undue inducement, exploitation, and biased enrollment. This article reviews the arguments for providing participants with financial incentives, ethical concerns about payment, and approaches to establishing appropriate compensation levels. It also makes recommendations for investigators, institutions, and oversight committees. PMID:26807399

  12. 75 FR 11990 - Chicago Executive Airports Noise Exposure Map Approval and Noise Compatibility Program Review

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... Airport under the provisions of 49 U.S.C. 47501 et. seq (Aviation Safety and Noise Abatement Act) and 14... program for public review and comment. Under 49 U.S.C. 47503 (the Aviation Safety and Noise Abatement Act... whether the proposed measures may reduce the level of aviation safety, create an undue burden on...

  13. Cyclone separator having boundary layer turbulence control

    DOEpatents

    Krishna, Coimbatore R.; Milau, Julius S.

    1985-01-01

    A cyclone separator including boundary layer turbulence control that is operable to prevent undue build-up of particulate material at selected critical areas on the separator walls, by selectively varying the fluid pressure at those areas to maintain the momentum of the vortex, thereby preventing particulate material from inducing turbulence in the boundary layer of the vortical fluid flow through the separator.

  14. Undue Lead Absorption and Lead Poisoning in Children: An Overview.

    ERIC Educational Resources Information Center

    Lin-Fu, J. S.

    The toxic effects of lead, a useful metal ubiquitous in the human environment, have long been known. The occupational hazards of lead poisoning were well established by the early 19th century, but plumbism in children caused by paint ingestion was not reported until the turn of the century. Even in 1924, the child was said to live in a "lead…

  15. 75 FR 2564 - Virginia Electric and Power Company D/B/A Dominion Virginia Power and Old Dominion Electric...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-15

    ..., submit an annual update to the application's final safety analysis report (FSAR), which is a part of the... public health or safety, and are consistent with the common defense and security; and (2) special... is authorized by law. No Undue Risk to Public Health and Safety The underlying purpose of 10 CFR 50...

  16. Reducing Undue Conservatism in "Higher Frequency" Structural Design Loads in Aerospace Components

    NASA Technical Reports Server (NTRS)

    Knight, J. Brent

    2012-01-01

    This study is intended to investigate the frequency dependency of significant strain due to vibratory loads in aerospace vehicle components. The notion that "higher frequency" dynamic loads applied as static loads is inherently conservative is perceived as widely accepted. This effort is focused on demonstrating that principle and attempting to evolve methods to capitalize on it to mitigate undue conservatism. It has been suggested that observations of higher frequency modes that resulted in very low corresponding strain did so due to those modes not being significant. Two avionics boxes, one with its first significant mode at 341 Hz and the other at 857 Hz, were attached to a flat panel installed on a curved orthogrid panel which was driven acoustically in tests performed at NASA/MSFC. Strain and acceleration were measured at select locations on each of the boxes. When possible, strain gage rosettes and accelerometers were installed on either side of a given structural member so that measured strain and acceleration data would directly correspond to one another. Ultimately, a frequency above which vibratory loads can be disregarded for purposes of static structural analyses and sizing of typical robust aerospace components is sought.

  17. Is all motivation good for learning? Dissociable influences of approach and avoidance motivation in declarative memory.

    PubMed

    Murty, Vishnu P; LaBar, Kevin S; Hamilton, Derek A; Adcock, R Alison

    2011-01-01

    The present study investigated the effects of approach versus avoidance motivation on declarative learning. Human participants navigated a virtual reality version of the Morris water task, a classic spatial memory paradigm, adapted to permit the experimental manipulation of motivation during learning. During this task, participants were instructed to navigate to correct platforms while avoiding incorrect platforms. To manipulate motivational states participants were either rewarded for navigating to correct locations (approach) or punished for navigating to incorrect platforms (avoidance). Participants' skin conductance levels (SCLs) were recorded during navigation to investigate the role of physiological arousal in motivated learning. Behavioral results revealed that, overall, approach motivation enhanced and avoidance motivation impaired memory performance compared to nonmotivated spatial learning. This advantage was evident across several performance indices, including accuracy, learning rate, path length, and proximity to platform locations during probe trials. SCL analysis revealed three key findings. First, within subjects, arousal interacted with approach motivation, such that high arousal on a given trial was associated with performance deficits. In addition, across subjects, high arousal negated or reversed the benefits of approach motivation. Finally, low-performing, highly aroused participants showed SCL responses similar to those of avoidance-motivation participants, suggesting that for these individuals, opportunities for reward may evoke states of learning similar to those typically evoked by threats of punishment. These results provide a novel characterization of how approach and avoidance motivation influence declarative memory and indicate a critical and selective role for arousal in determining how reinforcement influences goal-oriented learning.

  18. Living in Fear of Your Child's Pain: The Parent Fear of Pain Questionnaire

    PubMed Central

    Simons, Laura E.; Smith, Allison; Kaczynski, Karen; Basch, Molly

    2015-01-01

    Fear and avoidance have been consistently associated with poor pain-related outcomes in children. In the context of the pediatric pain experience, parent distress and behaviors can be highly influential. The current study validated the Parent Fear of Pain Questionnaire (PFOPQ) to assess a parent's fears and avoidance behaviors associated with their child's pain. Using the PFOPQ in conjunction with measures of parent and child pain-related variables, we tested the Interpersonal Fear Avoidance Model (IFAM). The sample comprised of 321 parents and their child with chronic or new-onset pain who presented to a multidisciplinary outpatient pain clinic. An exploratory factor analysis yielded a 4-factor structure for the PFOPQ consisting of Fear of Pain, Fear of Movement, Fear of School, and Avoidance. As hypothesized, Fear of Pain was most closely related to parent pain catastrophizing and child fear of pain, while Avoidance was most closely related to parent protective behaviors and child avoidance of activities. In testing the IFAM, parent behavior contributed directly and indirectly to child avoidance while parent fear and catastrophizing contributed indirectly to child avoidance through parent behavior and child fear and catastrophizing, in turn, influencing child functional disability levels. The current study provides the first measure of parent pain-related fears and avoidance behaviors and evaluates the theorized IFAM. These results underscore the important influence of parents on child pain-related outcomes and puts forth a psychometrically sound measure to assess parent fear and avoidance in the context of their child's pain. PMID:25630026

  19. Healthcare avoidance: a critical review.

    PubMed

    Byrne, Sharon K

    2008-01-01

    The purpose of this study is to provide a critical review and synthesis of theoretical and research literature documenting the impact of avoidance on healthcare behaviors, identify the factors that influence healthcare avoidance and delay in the adult population, and propose a direction for future research. The Theory of Reasoned Action, Theory of Planned Behavior, Theory of Care-Seeking Behavior, the Transtheoretical Model, and the Behavioral Model of Health Services Use/Utilization are utilized to elaborate on the context within which individual intention to engage in healthcare behaviors occurs. Research literature on the concept of healthcare avoidance obtained by using computerized searches of CINAHL, MEDLINE, PSYCH INFO, and HAPI databases, from 1995 to 2007, were reviewed. Studies were organized by professional disciplines. Healthcare avoidance is a common and highly variable experience. Multiple administrative, demographic, personal, and provider factors are related to healthcare avoidance, for example, distrust of providers and/or the science community, health beliefs, insurance status, or socioeconomic/income level. Although the concept is recognized by multiple disciplines, limited research studies address its impact on healthcare decision making. More systematic research is needed to determine correlates of healthcare avoidance. Such studies will help investigators identify patients at risk for avoidant behaviors and provide the basis for health-promoting interventions. Methodological challenges include identification of characteristics of individuals and environments that hinder healthcare behaviors, as well as, the complexity of measuring healthcare avoidance. Studies need to systematically explore the influence of avoidance behaviors on specific healthcare populations at risk.

  20. Living in fear of your child's pain: the Parent Fear of Pain Questionnaire.

    PubMed

    Simons, Laura E; Smith, Allison; Kaczynski, Karen; Basch, Molly

    2015-04-01

    Fear and avoidance have been consistently associated with poor pain-related outcomes in children. In the context of the pediatric pain experience, parent distress and behaviors can be highly influential. This study validated the Parent Fear of Pain Questionnaire (PFOPQ) to assess a parent's fears and avoidance behaviors associated with their child's pain. Using the PFOPQ in conjunction with measures of parent and child pain-related variables, we tested the interpersonal fear-avoidance model (IFAM). The sample comprised 321 parents and their child with chronic or new-onset pain who presented to a multidisciplinary outpatient pain clinic. An exploratory factor analysis yielded a 4-factor structure for the PFOPQ consisting of Fear of Pain, Fear of Movement, Fear of School, and Avoidance. As hypothesized, Fear of Pain was most closely related to parent pain catastrophizing and child fear of pain, whereas Avoidance was most closely related to parent protective behaviors and child avoidance of activities. In testing the IFAM, parent behavior contributed directly and indirectly to child avoidance, whereas parent fear and catastrophizing contributed indirectly to child avoidance through parent behavior and child fear and catastrophizing, in turn, influencing child functional disability levels. This study provides the first measure of parent pain-related fears and avoidance behaviors and evaluates the theorized IFAM. These results underscore the important influence of parents on child pain-related outcomes and put forth a psychometrically sound measure to assess parent fear and avoidance in the context of their child's pain.

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