U.S. Air Force Bomber Sustainment and Modernization: Background and Issues for Congress

DTIC Science & Technology

2013-04-23

the B-2’ s self- defense capabilities against U.S. Air Force Bomber Sustainment and Modernization: Issues for Congress...Sustaining U.S. Global Leadership: Priorities for the 21st Century Defense ; • the effectiveness and sustainability of the Air Force’s continuous...decisions considered by Congress, could have potential consequences for future national defense strategies and on U.S. long-range strike

Crisis Stability and Long-Range Strike: A Comparative Analysis of Fighters, Bombers, and Missiles

DTIC Science & Technology

2013-01-01

1947–1949 Crisis pakistan: Seize Kashmir hawker tempests , but not brandished or employed no India: Deny pakistan control of Kashmir hawker... tempests , but not brandished or employed no war Berlin 1948–1949 Crisis uSSR: Force western powers out of west Berlin Bombers and strike aircraft...resolution to border dispute B-24, B-57, hF-24, tempest , Mystère IV, Ouragan aircraft, but none brandished or employed no war Table C.1

An Investigation of the Bomber and Tanker Mating Process in the Single Integrated Operations Plan.

DTIC Science & Technology

1982-03-01

REFUELING C LOCATIONS ARE OPTIMIZED TO MAXIMIZE BOKSER ENTRY POINT C FUEL. BOMBER, TANKER, AND FRI DATA ARE INPUTS TO THlE C PROGRAM, AND THE INDIVIDUAL...NOTluI 50 UEAD(3.,E,1ND=I0)PRULAT(I).PRULONCI),PRICAP(I) COTOSO I$ NOPRlmI-1 TASm4 44. C C FOR EACH BOKSER TRACK, ASSIGN THE APPROPRIATE At mIN 0r C

[The Thule case. Mortality and hospitalization after the crash of an American B-52 bomber in 1968].

PubMed

Juel, K

1993-07-26

In 1968, a B-52 bomber carrying nuclear bombs crashed near the Thule US Air-Base in Greenland. By 1986, many cases of disease had been reported among Danish workers employed at the base. A database has been constructed from staff files of workers employed from 1963 to 1971. Of 4,322 workers, 98.7% were identified in 1987. The study group consisted of 1,202 workers employed during the clean up period (from the time of the crash until the last of the contaminated material had been removed). The reference group consisted of 3,120 workers employed outside the clean up period. No differences were found in total mortality, or mortality from cancer, heart disease or accidents between the groups after adjusting for age, marital status and length of employment. Mortality from suicide was lower in the study group. The hospitalization rates for the period 1977-1985 also showed no differences between the two groups. The conclusion of the register surveys is that no harmful effect on health due to the crash can be established by measuring mortality or hospital admissions.

Application of advanced speech technology in manned penetration bombers

NASA Astrophysics Data System (ADS)

North, R.; Lea, W.

1982-03-01

This report documents research on the potential use of speech technology in a manned penetration bomber aircraft (B-52/G and H). The objectives of the project were to analyze the pilot/copilot crewstation tasks over a three-hour-and forty-minute mission and determine the tasks that would benefit the most from conversion to speech recognition/generation, determine the technological feasibility of each of the identified tasks, and prioritize these tasks based on these criteria. Secondary objectives of the program were to enunciate research strategies in the application of speech technologies in airborne environments, and develop guidelines for briefing user commands on the potential of using speech technologies in the cockpit. The results of this study indicated that for the B-52 crewmember, speech recognition would be most beneficial for retrieving chart and procedural data that is contained in the flight manuals. Technological feasibility of these tasks indicated that the checklist and procedural retrieval tasks would be highly feasible for a speech recognition system.

Boeing B-47 Bomber with an Ejector at the 1957 NACA Lewis Inspection

NASA Image and Video Library

1957-10-21

A Boeing B-47 Stratojet bomber with a noise-reducing ejector on its engine at the 1957 Inspection of the National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory. Representatives from the military, aeronautical industry, universities, and the press were invited to the laboratory to be briefed on the NACA’s latest research efforts and tour the state- of- the- art test facilities. Over 1700 people visited the NACA Lewis in Cleveland, Ohio during October 7 - 10, 1957. By the mid-1950s, the aircraft industry was close to introducing jet airliners to the nation’s airways. The noise produced by the large jet engines, however, would pose a considerable problem for communities near airports. This problem was demonstrated at the 1957 Inspection by an NACA Lewis researcher who played longplay (LP) audio records of military jet engines for an audience. Tests showed that the source of the loudest noise was not the engine itself, but the mixing of the engine’s exhaust with the surrounding air in the atmosphere. The pressures resulting from this turbulence produced sound waves. One of Lewis’ first studies sought to design an exhaust nozzle that reduced the turbulence. A Pratt and Whitney J57 was tested in the Altitude Wind Tunnel with many of these nozzle configurations from January to May 1957. Researchers found that the various nozzle types did reduce the noise levels but also reduced the aircraft’s thrust. Afterwards, they determined that the addition of an NACA-developed ejector reduced the noise levels without diminishing thrust.

The Thule episode epidemiological follow up after the crash of a B-52 bomber in Greenland: registry linkage, mortality, hospital admissions.

PubMed

Juel, K

1992-08-01

The aim was to explore the pattern of disease in staff associated with a bomber that crashed in 1968 when carrying nuclear bombs. The database was constructed from staff files of Danish workers employed from 1 April 1963 to 1 July 1971. Comparison was made between subsequent mortality and hospital admissions of workers employed during the clean up of the crashed bomber, and those employed outside this period. The study involved workers employed at Thule US air base in Greenland. During 1963-1971, 4322 staff were employed at the air base. Of these, 4265 (98.7%) were identified in 1987, among whom 1202 workers were employed during the clean up period. No differences were found in total mortality, or mortality from cancer, heart disease, or accidents, after allowing for differences in age, marital status, or length of employment, between those employed during the clean up period and those employed at other times. Similarly, no difference in hospital admissions between the two groups was found. No harmful effects on health due to the crash were found, as measured by mortality and hospital admissions.

Infectious risk for suicide bomber attack victims: management of penetrative wounds in French Army personnel.

PubMed

de l'Escalopier, Nicolas; Mathieu, Laurent; Valade, Guillaume; Ficko, Cécile; Rigal, Sylvain

2016-05-01

In suicide bomber attacks (SBAs), the explosive forces may disperse fragments from the body of the bomber to which the device is attached. This biologic material can cause physical injury to bystanders and may represent a source of severe infectious diseases. Two French soldiers, victims of an SBA in Africa, were managed in the Percy Military Teaching Hospital. They sustained multiple injuries, including some caused by bony fragments converted into projectiles by the explosion. One patient had multiple superficial wounds managed conservatively. The other was treated surgically by serial debridement with removal of a bony piece related to the suicide bomber. The decision not to prescribe antiretroviral therapy was determined after discussion with infectious disease specialists. Blood tests for HIV, HCV and HBV were taken at months zero, three and six; all were negative. In the French Military Health Service, guidelines are based on evaluation of the viral status of the bomber and on the regional HIV prevalence breakpoint. There is no indication for HCV post-exposition prophylaxis (PEP). Accessible human foreign bodies related to an SBA should be removed as soon as possible, in association with antibiotic medication and a possible HIV PEP. These infectious risks have been discussed in some military and law enforcement literature. It should be a risk-based decision supported by medical intelligence.

Bomber Deterrence Missions: Criteria To Evaluate Mission Effectiveness

DTIC Science & Technology

2016-02-16

International Relations from Brigham Young University and a Master of Science degree in Aviation Safety Management from the University of Central...AIR WAR COLLEGE AIR UNIVERSITY BOMBER DETERRENCE MISSIONS: CRITERIA TO EVALUATE MISSION EFFECTIVENESS by Bradley L. Cochran, Col, USAF A...paper are those of the author and do not reflect the official policy or position of the US government, the Department of Defense, or Air University

X-2 in flight after drop from B-50 mothership

NASA Technical Reports Server (NTRS)

1956-01-01

attempted to bail out and was killed when the capsule impacted on the Edwards bombing range. The rest of the X-2 crashed five miles away. The X-2 was a swept-wing, rocket-powered aircraft designed to fly faster than Mach 3 (three times the speed of sound). It was built for the U.S. Air Force by the Bell Aircraft Company, Buffalo, New York. The X-2 was flown to investigate the problems of aerodynamic heating as well as stability and control effectiveness at high altitudes and high speeds (in excess of Mach 3). Bell aircraft built two X-2 aircraft. These were constructed of K-monel (a copper and nickel alloy) for the fuselage and stainless steel for the swept wings and control surfaces. The aircraft had ejectable nose capsules instead of ejection seats because the development of ejection seats had not reached maturity at the time the X-2 was conceived. The X-2 ejection canopy was successfully tested using a German V-2 rocket. The X-2 used a skid-type landing gear to make room for more fuel. The airplane was air launched from a modified Boeing B-50 Superfortress Bomber. X-2 Number 1 made its first unpowered glide flight on Aug. 5, 1954, and made a total of 17 (4 glide and 13 powered) flights before it was lost Sept. 27, 1956. The pilot on Flight 17, Capt. Milburn Apt, had flown the aircraft to a record speed of Mach 3.2 (2,094 mph), thus becoming the first person to exceed Mach 3. During that last flight, inertial coupling occurred and the pilot was killed. The aircraft suffered little damage in the crash, resulting in proposals (never implemented) from the Langley Memorial Aeronautical Laboratory, Hampton, Virginia, to rebuild it for use in a hypersonic (Mach 5+) test program. In 1953, X-2 Number 2 was lost in an in-flight explosion while at the Bell Aircraft Company during captive flight trials and was jettisoned into Lake Ontario. The Air Force had previously flown the aircraft on three glide flights at Edwards Air Force Base, California, in 1952. Although the NACA's High

The Thule episode epidemiological follow up after the crash of a B-52 bomber in Greenland: registry linkage, mortality, hospital admissions.

PubMed Central

Juel, K

1992-01-01

STUDY OBJECTIVES--The aim was to explore the pattern of disease in staff associated with a bomber that crashed in 1968 when carrying nuclear bombs. DESIGN--The database was constructed from staff files of Danish workers employed from 1 April 1963 to 1 July 1971. Comparison was made between subsequent mortality and hospital admissions of workers employed during the clean up of the crashed bomber, and those employed outside this period. SETTING--The study involved workers employed at Thule US air base in Greenland. MAIN RESULTS--During 1963-1971, 4322 staff were employed at the air base. Of these, 4265 (98.7%) were identified in 1987, among whom 1202 workers were employed during the clean up period. No differences were found in total mortality, or mortality from cancer, heart disease, or accidents, after allowing for differences in age, marital status, or length of employment, between those employed during the clean up period and those employed at other times. Similarly, no difference in hospital admissions between the two groups was found. CONCLUSIONS--No harmful effects on health due to the crash were found, as measured by mortality and hospital admissions. PMID:1431702

Encyclopedia of U.S. Air Force Aircraft and Missile Systems. Volume 2. Post-World War II Bombers, 1945-1973

DTIC Science & Technology

1988-01-01

36 program. Of perhaps greater import, this cooperation would blend Northrop’s engineering skill and Convair’s experience in quantity production of...projects. Small swept winglets were attached along- side the nose of the reconfigured bomber-NB-52E. A long probe extended from the nose of the modified...the aircraft’s winglets (canards), which reduced 30 percent of the vertical and 50 percent of the horizontal vibrations caused by air gusts. The NB

Suicide bombers form a new injury profile.

PubMed

Aharonson-Daniel, Limor; Klein, Yoram; Peleg, Kobi

2006-12-01

Recent explosions of suicide bombers introduced new and unique profiles of injury. Explosives frequently included small metal parts, increasing severity of injuries, challenging both physicians and healthcare systems. Timely detonation in crowded and confined spaces further increased explosion effect. Israel National Trauma Registry data on hospitalized terror casualties between October 1, 2000 and December 31, 2004 were analyzed. A total of 1155 patients injured by explosion were studied. Nearly 30% suffered severe to critical injuries (ISS > or = 16); severe injuries (AIS > or = 3) were more prevalent than in other trauma. Triage has changed as metal parts contained in bombs penetrate the human body with great force and may result in tiny entry wounds easily concealed by hair, clothes etc. A total of 36.6% had a computed tomography (CT), 26.8% had ultrasound scanning, and 53.2% had an x-ray in the emergency department. From the emergency department, 28.3% went directly to the operating room, 10.1% to the intensive care unit, and 58.4% directly to the ward. Injuries were mostly internal, open wounds, and burns, with an excess of injuries to nerves and to blood vessels compared with other trauma mechanisms. A high rate of surgical procedures was recorded, including thoracotomies, laparotomies, craniotomies, and vascular surgery. In certain cases, there were simultaneous multiple injuries that required competing forms of treatment, such as burns and blast lung. Bombs containing metal fragments detonated by suicide bombers in crowded locations change patterns and severity of injury in a civil population. Specific injuries will require tailored approaches, an open mind, and close collaboration and cooperation between trauma surgeons to share experience, opinions, and ideas. Findings presented have implications for triage, diagnosis, treatment, hospital organization, and the definition of surge capacity.

Bomber: The Formation and Early Years of Strategic Air Command

DTIC Science & Technology

2012-11-01

USSTAF US Strategic Air Forces VDT variable discharge turbine (engine) VFR visual flight rules VHB very heavy bomber VJ-Day Victory over Japan Day WSEG...projectile from high altitude, from a moving and unstable platform, in strong and unpredictable winds , against ground targets four to five miles below...aircraft that could carry the requisite bomb load over long distances and do so without incur- ring prohibitive losses to enemy defenses were not yet

1. OVERALL VIEW TO NORTH, SHOWING BOMBER REVETMENT AR8 IN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. OVERALL VIEW TO NORTH, SHOWING BOMBER REVETMENT AR-8 IN RELATION TO THE HANGARS OF MAIN BASE IN THE FAR DISTANCE, AND THE AIRPLANE FIREFIGHTING TRAINING MODEL (STRUCTURE NO. 273) AT FAR RIGHT. PURSUIT PLANE REVETMENT AR-9 IS DIRECTLY BEHIND AR-8, THROUGH HIDDEN FROM THIS ANGLE. (Panoramic view number 1 of 2 for AR-8). - Edwards Air Force Base, South Base, Rammed Earth Aircraft Dispersal Revetments, Western Shore of Rogers Dry Lake, Boron, Kern County, CA

Countering Putins Nuclear-Backed Aggression with a Continuous Nuclear-Capable Bomber Presence

DTIC Science & Technology

2016-05-13

backed aggression can only be answered by a visible increase in nuclear capability in Europe. A nuclear-capable bomber force that permanently rotates ...permanently rotates through the EUCOM Area of Responsibility (AOR) would provide the United States with the ability to attack Putin’s strategy in three ways...One nuclear detonation in Europe would change the world. A BMD system cannot promise countries that it will negate every Russian nuclear missile

A Simulation Based Methodology to Examine the B-1B’s AN/ALQ-161 Maintenance Process

DTIC Science & Technology

2010-03-01

Paper, 2001). “The Air Force does not think of, or advertise , bombers as interchangeable. The B-1, B-2 and B-52 all have a specific mission area and...Path Modeling ( CPM ), Goal Programming, EOQ, Nonlinear Programming Predictive Models unknown, ill-defined known or under the decision-maker’s

A Simulation Based Methodology to Examine the B-1B’s AN/ALQ-161 Maintenance Process

DTIC Science & Technology

2010-03-01

2001). “The Air Force does not think of, or advertise , bombers as interchangeable. The B-1, B-2 and B-52 all have a specific mission area and 2...Modeling ( CPM ), Goal Programming, EOQ, Nonlinear Programming Predictive Models unknown, ill-defined known or under the decision-maker’s control

Measuring the Flight Speed of Fire Bombers from Photos: An In-Class Exercise in Introductory Kinematics

ERIC Educational Resources Information Center

Lowe, Greg W.; Ayars, Eric

2010-01-01

In the western half of the United States, fire bombers are not an uncommon sight. During the "fire season," which can extend from June through November, these specially modified aircraft are used to drop fire retardant chemicals or water on wildfires. It can be an entertaining and instructive classroom exercise to use pictures of these…

32 CFR 806b.50 - Computer matching.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 6 2013-07-01 2013-07-01 false Computer matching. 806b.50 Section 806b.50... PROGRAM Disclosing Records to Third Parties § 806b.50 Computer matching. Computer matching programs... on forms used in applying for benefits. Coordinate computer matching statements on forms with Air...

32 CFR 806b.50 - Computer matching.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 6 2014-07-01 2014-07-01 false Computer matching. 806b.50 Section 806b.50... PROGRAM Disclosing Records to Third Parties § 806b.50 Computer matching. Computer matching programs... on forms used in applying for benefits. Coordinate computer matching statements on forms with Air...

32 CFR 806b.50 - Computer matching.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 6 2012-07-01 2012-07-01 false Computer matching. 806b.50 Section 806b.50... PROGRAM Disclosing Records to Third Parties § 806b.50 Computer matching. Computer matching programs... on forms used in applying for benefits. Coordinate computer matching statements on forms with Air...

32 CFR 806b.50 - Computer matching.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Computer matching. 806b.50 Section 806b.50... PROGRAM Disclosing Records to Third Parties § 806b.50 Computer matching. Computer matching programs... on forms used in applying for benefits. Coordinate computer matching statements on forms with Air...

32 CFR 806b.50 - Computer matching.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 6 2011-07-01 2011-07-01 false Computer matching. 806b.50 Section 806b.50... PROGRAM Disclosing Records to Third Parties § 806b.50 Computer matching. Computer matching programs... on forms used in applying for benefits. Coordinate computer matching statements on forms with Air...

Consolidated B-24M Liberator Equipped for Icing Research

NASA Image and Video Library

1946-07-21

A Consolidated B-25M Liberator modified for icing research by the National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory. NACA Lewis performed a limited amount of icing research during World War II, but the program expanded significantly in 1946. The accumulation of ice on aircraft was a continual problem. The ice formations could result in extra weight, aerodynamic penalties, and blockage engine inlets. Although the Lewis icing researchers utilized numerous aircraft, the program’s two workhorses were the B-24M Liberator, seen here, and a North American XB-25E Mitchell. The Consolidated Aircraft Company created the four-engine bomber in the early 1940s. During World War II the bomber was employed on long-duration bombing missions in both Europe and the Pacific. Production of the B-24M version did not begin until October 1944 with the end of the war in Europe approaching. This resulted in scores of unneeded bombers when hostilities ended. This B-24M arrived at the NACA Lewis laboratory in November 1945. At Lewis the B-24M was repeatedly modified to study ice accretion on aircraft components. Researchers analyzed different anti-icing and deicing strategies and gathered statistical ice measurement data. The B-24M was also used to study ice buildup on jet engines. A General Electric I-16 engine was installed in the aircraft’s waist compartment with an air scoop on the top of the aircraft to duct air to the engine. Water spray nozzles inside the aircraft were employed to simulate icing conditions at the turbojet’s inlet.

10 CFR 50.36b - Environmental conditions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Environmental conditions. 50.36b Section 50.36b Energy... § 50.36b Environmental conditions. (a) Each construction permit under this part, each early site permit... conditions will be derived from information contained in the environmental report submitted pursuant to § 51...

26 CFR 1.50B-4 - Partnerships.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Partnerships. 1.50B-4 Section 1.50B-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Rules for Computing Credit for Expenses of Work Incentive Programs § 1.50B-4 Partnerships. (a) General rule—(1) In general...

X-38 on B-52 Wing Pylon - View from Observation Window

NASA Image and Video Library

1997-11-19

A unique, close-up view of the X-38 under the wing of NASA's B-52 mothership prior to launch of the lifting-body research vehicle. The photo was taken from the observation window of the B-52 bomber as it banked in flight.

GENERAL VIEW OF THE PRODUCTION LINE BEING CONVERTED FROM B26 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF THE PRODUCTION LINE BEING CONVERTED FROM B-26 TO B-29 PRODUCTION SHOWING THE LINK-BELT CONVEYOR SYSTEM AND ENGINE NACELLES READY FOR ASSEMBLY. WHO, 1944 - Offutt Air Force Base, Glenn L. Martin-Nebraska Bomber Plant, Building D, Peacekeeper Drive, Bellevue, Sarpy County, NE

An analysis of fuel conserving operational procedures and design modifications for bomber/transport aircraft. volume ii. Final report, 7 June 1976-7 July 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aggarwal, R.K.

1978-07-01

Various proposed improvements in the design and operational procedures for bomber/transport aircraft are evaluated. The evaluation is performed in terms of the estimated savings in fuel consumption and in Direct Operating Cost (DOC). As an aid in the evaluation of design modifications, graphs of fuel and DOC savings as a function of the design parameters are developed. These graphs are based on actual mission trajectory data rather than some typical trajectory profile. The actual mission data is presented in terms of histograms which provide statistical information concerning altitude, air speed, take-off weight, landing weight, and mission time. Separate analyses aremore » performed on the following aircraft: the B-52G, the B-52H, the KC-135, the C-141, the C-130, and the C-5A. (Author)« less

26 CFR 1.50B-3 - Estates and trusts.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Estates and trusts. 1.50B-3 Section 1.50B-3... Computing Credit for Expenses of Work Incentive Programs § 1.50B-3 Estates and trusts. (a) General rule—(1) In general. In the case of an estate or trust, WIN expenses (as defined in paragraph (a) of § 1.50B-1...

An analysis of fuel conserving operational procedures and design modifications for bomber/transport aircraft. Volume I. Executive summary. Final report, 7 June 1976-7 July 1978

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aggarwal, R.

1978-07-01

Various proposed improvements in the design and operational procedures for bomber/transport aircraft are evaluated. The evaluation is performed in terms of the estimated savings in fuel consumption and in Direct Operating Cost (DOC). As an aid in the evaluation of design modifications, graphs of fuel and DOC savings as a function of the design parameters are developed. These graphs are based on actual mission trajectory data rather than some type trajectory profile. The actual mission data is presented in terms of histograms which provide statistical information concerning altitude, air speed, take-off weight, landing weights, and mission time. Separate analyses aremore » performed on the following aircraft: the B-52G, the B-52H, the KC-135, the C-141, the C-130, and the C-5A.« less

Time histories of horizontal-tail loads, elevator loads, and deformations on a jet-powered bomber airplane during abrupt pitching maneuvers at approximately 20,000 feet

NASA Technical Reports Server (NTRS)

Wiener, Bernard; Harris, Agnes E

1950-01-01

Time histories are presented of horizontal-tail loads, elevator loads, and deformations on a jet-powered bomber during abrupt pitching maneuvers at a pressure altitude of approximately 20,000 feet. The normal and pitching accelerations measured varied from -0.90b to 3.41g and from -0.73 to 0.80 radian per second per second (sic), respectively, with a Mach number variation of from 0.40 to o.75. The maximum horizontal-tail load measured was 17,250 pounds down. The maximum elevator load was 1900 pounds up. The stabilizer twisted a maximum of 0.76 degrees leading edge down at the tip. The greatest fuselage deflection at the tail was about 1.7 inches down.

Time Variation of the Distance Separating Bomb and Dive Bomber Subsequent to Bomb Release

NASA Technical Reports Server (NTRS)

Mathews, Charles W.

1952-01-01

A study has been made of the variation of the distance separating bomb and aircraft with time after release as applied to dive-bombing operations, Separation distances determined from this study are presented in terms of two variables only, dive angle and maximum airplane accelerometer reading; the values of separation distance include the effects of delay in initiation of the pull-out and lag in attainment of the maximum normal acceleration.Contains analysis and calculations of the separation distances between bomb and dive bomber following bomb release, Separation distances as determined by the dive angle and the maximum airplane accelerometer reading are presented in a single chart.

Aviators and Air Combat: A Study of the U.S. Eighth Air Force and R.A.F. Bomber Command

DTIC Science & Technology

1992-07-01

These were the human qualities, above all others, that air war seemed to demand . The reasons for this are apparent from the nature of the conflict. If we...are fundamentally similar with respect to the human dimension. Even so, the terrific demands placed on aerial combatants in a Clausewitzian sense...Bomber Offensive. Subsequent chapters of the thesis deal directly with issues arising out of the extraordinarily demanding nature of air combat

Range Performance of Bombers Powered by Turbine-Propeller Power Plants

NASA Technical Reports Server (NTRS)

Cline, Charles W.

1950-01-01

Calculations have been made to find range? attainable by bombers of gross weights from l40,000 to 300,000 pounds powered by turbine-propeller power plants. Only conventional configurations were considered and emphasis was placed upon using data for structural and aerodynamic characteristics which are typical of modern military airplanes. An effort was made to limit the various parameters invoked in the airplane configuration to practical values. Therefore, extremely high wing loadings, large amounts of sweepback, and very high aspect ratios have not been considered. Power-plant performance was based upon the performance of a typical turbine-propeller engine equipped with propellers designed to maintain high efficiencies at high-subsonic speeds. Results indicated, in general, that the greatest range, for a given gross weight, is obtained by airplanes of high wing loading, unless the higher cruising speeds associated with the high-wing-loading airplanes require-the use of thinner wing sections. Further results showed the effect of cruising at-high speeds, of operation at very high altitudes, and of carrying large bomb loads.

Very low cost stand-off suicide bomber detection system using human gait analysis to screen potential bomb carrying individuals

NASA Astrophysics Data System (ADS)

Greneker, Gene, III

2005-05-01

Individuals who carry bombs on their bodies and detonate those bombs in public places are a security problem. There is belief that suicide bombings currently used in the mid-east may spread to the United States if the organized terrorist groups operating in the United States are not identified and the cell members arrested. While bombs in vehicles are the primary method currently used to spread terror in Iraq, U. S. warfighters are starting to face suicide bombers. This may become more of the situation if a stand-off detection capability is developed for the vehicle bomb case. This paper presents a concept, that if developed and commercialized, could provide an inexpensive suicide bomber screening system that could be used to screen individuals approaching a checkpoint while the individual is still 500 to 1,000 feet from the checkpoint. The proposed system measures both the radar cross-section of the individual and the radar derived gait characteristics that are associated with individuals carrying a bomb on their body. GTRI researchers propose to use human gait characteristics, as detected by radar, to determine if a human subject who is carrying no visible load on the body is actually carrying a concealed load under their clothes. The use of radar gait as a metric for the detection (as opposed to a video system) of a suicide bomber is being proposed because detection of gait characteristics are thought to be less sensitive to where the bomb is located on the body, lighting conditions, and the fact that the legs may be shrouded in a robe. The detection of a bomb using radar gait analysis may also prove to be less sensitive to changing tactics regarding where the bomb is placed on the body. An inert suicide bomb vest was constructed using water pipes to simulate the explosive devices. Wiring was added to simulated detonators. The vest weighs approximately 35 pounds. Radar data was taken on the volunteer subject wearing the vest that simulated the suicide bomb. This

Immunochemical characterization of temperature-regulated production of enterocin L50 (EntL50A and EntL50B), enterocin P, and enterocin Q by Enterococcus faecium L50.

PubMed

Criado, Raquel; Gutiérrez, Jorge; Martín, María; Herranz, Carmen; Hernández, Pablo E; Cintas, Luis M

2006-12-01

Polyclonal antibodies with specificity for enterocin L50A (EntL50A), enterocin L50B (EntL50B), and enterocin Q (EntQ) produced by Enterococcus faecium L50 have been generated by immunization of rabbits with chemically synthesized peptides derived from the C terminus of EntL50A (LR1) and EntL50B (LR2) and from the complete enterocin Q (EntQ) conjugated to the carrier protein keyhole limpet hemocyanin (KLH). The sensitivity and specificity of these antibodies were evaluated by a noncompetitive indirect enzyme-linked immunosorbent assay (NCI-ELISA) and a competitive indirect ELISA (CI-ELISA). The NCI-ELISA was valuable for detecting anti-EntL50A-, anti-EntL50B-, and anti-EntQ-specific antibodies in the sera of the LR1-KLH-, LR2-KLH-, and EntQ-KLH-immunized animals, respectively. Moreover, these antibodies and those specific for enterocin P (EntP) obtained in a previous work (J. Gutiérrez, R. Criado, R. Citti, M. Martín, C. Herranz, M. F. Fernández, L. M. Cintas, and P. E. Hernández, J. Agric. Food Chem. 52:2247-2255, 2004) were used in an NCI-ELISA to detect and quantify the production of EntL50A, EntL50B, EntP, and EntQ by the multiple-bacteriocin producer E. faecium L50 grown at different temperatures (16 to 47 degrees C). Our results show that temperature has a strong influence on bacteriocin production by this strain. EntL50A and EntL50B are synthesized at 16 to 32 degrees C, but production becomes negligible when the growth temperature is above 37 degrees C, whereas EntP and EntQ are synthesized at temperatures ranging from 16 to 47 degrees C. Maximum EntL50A and EntL50B production was detected at 25 degrees C, while EntP and EntQ are maximally produced at 37 and 47 degrees C, respectively. The loss of plasmid pCIZ1 (50 kb) and/or pCIZ2 (7.4 kb), encoding EntL50A and EntL50B as well as EntQ, respectively, resulted in a significant increase in production and stability of the chromosomally encoded EntP.

33 CFR 110.50b - Mystic Harbor, Groton and Stonington, Conn.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Mystic Harbor, Groton and Stonington, Conn. 110.50b Section 110.50b Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.50b Mystic Harbor, Groton and...

33 CFR 110.50b - Mystic Harbor, Groton and Stonington, Conn.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Mystic Harbor, Groton and Stonington, Conn. 110.50b Section 110.50b Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.50b Mystic Harbor, Groton and...

33 CFR 110.50b - Mystic Harbor, Groton and Stonington, Conn.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Mystic Harbor, Groton and Stonington, Conn. 110.50b Section 110.50b Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.50b Mystic Harbor, Groton and...

33 CFR 110.50b - Mystic Harbor, Groton and Stonington, Conn.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Mystic Harbor, Groton and Stonington, Conn. 110.50b Section 110.50b Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.50b Mystic Harbor, Groton and...

33 CFR 110.50b - Mystic Harbor, Groton and Stonington, Conn.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Mystic Harbor, Groton and Stonington, Conn. 110.50b Section 110.50b Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.50b Mystic Harbor, Groton and...

Immunochemical Characterization of Temperature-Regulated Production of Enterocin L50 (EntL50A and EntL50B), Enterocin P, and Enterocin Q by Enterococcus faecium L50▿

PubMed Central

Criado, Raquel; Gutiérrez, Jorge; Martín, María; Herranz, Carmen; Hernández, Pablo E.; Cintas, Luis M.

2006-01-01

Polyclonal antibodies with specificity for enterocin L50A (EntL50A), enterocin L50B (EntL50B), and enterocin Q (EntQ) produced by Enterococcus faecium L50 have been generated by immunization of rabbits with chemically synthesized peptides derived from the C terminus of EntL50A (LR1) and EntL50B (LR2) and from the complete enterocin Q (EntQ) conjugated to the carrier protein keyhole limpet hemocyanin (KLH). The sensitivity and specificity of these antibodies were evaluated by a noncompetitive indirect enzyme-linked immunosorbent assay (NCI-ELISA) and a competitive indirect ELISA (CI-ELISA). The NCI-ELISA was valuable for detecting anti-EntL50A-, anti-EntL50B-, and anti-EntQ-specific antibodies in the sera of the LR1-KLH-, LR2-KLH-, and EntQ-KLH-immunized animals, respectively. Moreover, these antibodies and those specific for enterocin P (EntP) obtained in a previous work (J. Gutiérrez, R. Criado, R. Citti, M. Martín, C. Herranz, M. F. Fernández, L. M. Cintas, and P. E. Hernández, J. Agric. Food Chem. 52:2247-2255, 2004) were used in an NCI-ELISA to detect and quantify the production of EntL50A, EntL50B, EntP, and EntQ by the multiple-bacteriocin producer E. faecium L50 grown at different temperatures (16 to 47°C). Our results show that temperature has a strong influence on bacteriocin production by this strain. EntL50A and EntL50B are synthesized at 16 to 32°C, but production becomes negligible when the growth temperature is above 37°C, whereas EntP and EntQ are synthesized at temperatures ranging from 16 to 47°C. Maximum EntL50A and EntL50B production was detected at 25°C, while EntP and EntQ are maximally produced at 37 and 47°C, respectively. The loss of plasmid pCIZ1 (50 kb) and/or pCIZ2 (7.4 kb), encoding EntL50A and EntL50B as well as EntQ, respectively, resulted in a significant increase in production and stability of the chromosomally encoded EntP. PMID:17056686

26 CFR 1.50B-2 - Electing small business corporations.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 1 2012-04-01 2012-04-01 false Electing small business corporations. 1.50B-2... business corporations. (a) General rule—(1) In general. In the case of an electing small business corporation (as defined in section 1371 (b)), WIN expenses (as defined in paragraph (a) of § 1.50B-1) shall be...

26 CFR 1.50B-2 - Electing small business corporations.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 1 2014-04-01 2013-04-01 true Electing small business corporations. 1.50B-2... business corporations. (a) General rule—(1) In general. In the case of an electing small business corporation (as defined in section 1371 (b)), WIN expenses (as defined in paragraph (a) of § 1.50B-1) shall be...

26 CFR 1.50B-2 - Electing small business corporations.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 1 2013-04-01 2013-04-01 false Electing small business corporations. 1.50B-2... business corporations. (a) General rule—(1) In general. In the case of an electing small business corporation (as defined in section 1371 (b)), WIN expenses (as defined in paragraph (a) of § 1.50B-1) shall be...

Development of Bacteriocinogenic Strains of Saccharomyces cerevisiae Heterologously Expressing and Secreting the Leaderless Enterocin L50 Peptides L50A and L50B from Enterococcus faecium L50▿

PubMed Central

Basanta, Antonio; Herranz, Carmen; Gutiérrez, Jorge; Criado, Raquel; Hernández, Pablo E.; Cintas, Luis M.

2009-01-01

A segregationally stable expression and secretion vector for Saccharomyces cerevisiae, named pYABD01, was constructed by cloning the yeast gene region encoding the mating pheromone α-factor 1 secretion signal (MFα1s) into the S. cerevisiae high-copy-number expression vector pYES2. The structural genes of the two leaderless peptides of enterocin L50 (EntL50A and EntL50B) from Enterococcus faecium L50 were cloned, separately (entL50A or entL50B) and together (entL50AB), into pYABD01 under the control of the galactose-inducible promoter PGAL1. The generation of recombinant S. cerevisiae strains heterologously expressing and secreting biologically active EntL50A and EntL50B demonstrates the suitability of the MFα1s-containing vector pYABD01 to direct processing and secretion of these antimicrobial peptides through the S. cerevisiae Sec system. PMID:19218405

Redox Regulation of NF-κB p50 and M1 Polarization in Microglia

PubMed Central

Taetzsch, Thomas; Levesque, Shannon; McGraw, Constance; Brookins, Savannah; Luqa, Rafy; Bonini, Marcelo G.; Mason, Ronald P.; Oh, Unsong; Block, Michelle L.

2014-01-01

Redox-signaling is implicated in deleterious microglial activation underlying CNS disease, but how ROS program aberrant microglial function is unknown. Here, the oxidation of NF-κB p50 to a free radical intermediate is identified as a marker of dysfunctional M1 (pro-inflammatory) polarization in microglia. Microglia exposed to steady fluxes of H2O2 showed altered NF-κB p50 protein-protein interactions, decreased NF-κB p50 DNA binding, and augmented late-stage TNFα expression, indicating that H2O2 impairs NF-κB p50 function and prolongs amplified M1 activation. NF-κB p50−/− mice and cultures exhibited a disrupted M2 (alternative) response and impaired resolution of the M1 response. Persistent neuroinflammation continued 1 week after LPS (1mg/kg, IP) administration in the NF-κB p50−/− mice. However, peripheral inflammation had already resolved in both strains of mice. Treatment with the spin-trap DMPO mildly reduced LPS-induced 22 h TNFα in the brain in NF-κB p50+/+ mice. Interestingly, DMPO failed to reduce and strongly augmented brain TNFα production in NF-κB p50−/− mice, implicating a fundamental role for NF-κB p50 in the regulation of chronic neuroinflammation by free radicals. These data identify NF-κB p50 as a key redox-signaling mechanism regulating the M1/M2 balance in microglia, where loss of function leads to a CNS-specific vulnerability to chronic inflammation. PMID:25331559

Negative thermal expansion and anomalies of heat capacity of LuB 50 at low temperatures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Novikov, V. V.; Zhemoedov, N. A.; Matovnikov, A. V.

2015-07-20

Heat capacity and thermal expansion of LuB 50 boride were experimentally studied in the 2–300 K temperature range. The data reveal an anomalous contribution to the heat capacity at low temperatures. The value of this contribution is proportional to the first degree of temperature. It was identified that this anomaly in heat capacity is caused by the effect of disorder in the LuB 50 crystalline structure and it can be described in the soft atomic potential model (SAP). The parameters of the approximation were determined. The temperature dependence of LuB 50 heat capacity in the whole temperature range was approximatedmore » by the sum of SAP contribution, Debye and two Einstein components. The parameters of SAP contribution for LuB 50 were compared to the corresponding values for LuB 66, which was studied earlier. Negative thermal expansion at low temperatures was experimentally observed for LuB 50. The analysis of the experimental temperature dependence for the Gruneisen parameter of LuB 50 suggested that the low-frequency oscillations, described in SAP mode, are responsible for the negative thermal expansion. As a result, the glasslike character of the behavior of LuB 50 thermal characteristics at low temperatures was confirmed.« less

Makers of the United States Air Force,

DTIC Science & Technology

1987-01-01

in a larger percentage of high performance , large capacity bombers. . ... In every test or exercise we have ever had . .. this plane stands out head...believed large formations of heavily armed, high - performance B-17Es could succeed, but a serious effort should be made to develop escort fighters. No...multi-engined bombers: one with high speed , substantial firepower, and short range; the other, a long-range bomber with heavy load capacity. In the summer

50 CFR Figures 7-9b to Part 223 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false [Reserved] 7 Figures 7-9b to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Figures 7-9b to Part 223...

50 CFR Figures 7-9b to Part 223 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false [Reserved] 7 Figures 7-9b to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE AND ANADROMOUS SPECIES Figures 7-9b to Part 223...

Targeted deletion of NF-κB p50 diminishes the cardioprotection of histone deacetylase inhibition

PubMed Central

Zhang, L. X.; Zhao, Y.; Cheng, G.; Guo, T. L.; Chin, Y. E.; Liu, P. Y.

2010-01-01

We have recently demonstrated that the inhibition of histone deacetylases (HDAC) protects the heart against ischemia-reperfusion (I/R) injury. The mechanism by which HDAC inhibition confers myocardial protection remains unknown. The purpose of this study is to investigate whether the disruption of NF-κB p50 would eliminate the protective effects of HDAC inhibition. Wild-type and NF-κB p50-deficient mice were treated with trichostatin A (TSA; 0.1 mg/kg ip), a potent inhibitor of HDACs. Twenty-four hours later, the hearts were perfused in Langendorff model and subjected to 30 min of ischemia and 30 min of reperfusion. Inhibition of HDACs by TSA in wild-type mice produced marked improvements in left ventricular end-diastolic pressure, left ventricular rate pressure product, and the reduction of infarct size compared with non-TSA-treated group. TSA-induced cardioprotection in wild-type animals was absent with genetic deletion of NF-κB p50 subunit. Notably, Western blot displayed a significant increase in nuclear NF-κB p50 and the immunoprecipitation demonstrated a remarkable acetylation of NF-κB p50 at lysine residues following HDAC inhibition. EMSA exhibited a subsequent increase in NF-κB DNA binding activity. Luciferase assay demonstrated an activation of NF-κB by HDAC inhibition. The pretreatment of H9c2 cardiomyoblasts with TSA (50 nmol/l) decreased cell necrosis and increased in cell viability in simulated ischemia. The resistance of H9c2 cardiomyoblasts to simulated ischemia by HDAC inhibition was eliminated by genetic knockdown of NF-κB p50 with transfection of NF-κB p50 short interfering RNA but not scrambled short interfering RNA. These results suggest that NF-κB p50 acetylation and activation play a pivotal role in HDAC inhibition-induced cardioprotection. PMID:20382965

Use of the Yeast Pichia pastoris as an Expression Host for Secretion of Enterocin L50, a Leaderless Two-Peptide (L50A and L50B) Bacteriocin from Enterococcus faecium L50▿

PubMed Central

Basanta, Antonio; Gómez-Sala, Beatriz; Sánchez, Jorge; Diep, Dzung B.; Herranz, Carmen; Hernández, Pablo E.; Cintas, Luis M.

2010-01-01

In this work, we report the expression and secretion of the leaderless two-peptide (EntL50A and EntL50B) bacteriocin enterocin L50 from Enterococcus faecium L50 by the methylotrophic yeast Pichia pastoris X-33. The bacteriocin structural genes entL50A and entL50B were fused to the Saccharomyces cerevisiae gene region encoding the mating pheromone α-factor 1 secretion signal (MFα1s) and cloned, separately and together (entL50AB), into the P. pastoris expression and secretion vector pPICZαA, which contains the methanol-inducible alcohol oxidase promoter (PAOX1) to express the fusion genes. After transfer into the yeast, the recombinant plasmids were integrated into the genome, resulting in three bacteriocinogenic yeast strains able to produce and secrete the individual bacteriocin peptides EntL50A and EntL50B separately and together. The secretion was efficiently directed by MFα1s through the Sec system, and the precursor peptides were found to be correctly processed to form mature and active bacteriocin peptides. The present work describes for the first time the heterologous expression and secretion of a two-peptide non-pediocin-like bacteriocin by a yeast. PMID:20348300

p21 mediates macrophage reprogramming through regulation of p50-p50 NF-κB and IFN-β

PubMed Central

Hernández-Jiménez, Enrique; Shokri, Rahman; Carmona-Rodríguez, Lorena; Mañes, Santos; Álvarez-Mon, Melchor; López-Collazo, Eduardo; Martínez-A, Carlos

2016-01-01

M1 and M2 macrophage phenotypes, which mediate proinflammatory and antiinflammatory functions, respectively, represent the extremes of immunoregulatory plasticity in the macrophage population. This plasticity can also result in intermediate macrophage states that support a balance between these opposing functions. In sepsis, M1 macrophages can compensate for hyperinflammation by acquiring an M2-like immunosuppressed status that increases the risk of secondary infection and death. The M1 to M2 macrophage reprogramming that develops during LPS tolerance resembles the pathological antiinflammatory response to sepsis. Here, we determined that p21 regulates macrophage reprogramming by shifting the balance between active p65-p50 and inhibitory p50-p50 NF-κB pathways. p21 deficiency reduced the DNA-binding affinity of the p50-p50 homodimer in LPS-primed and -rechallenged macrophages, impairing their ability to attenuate IFN-β production and acquire an M2-like hyporesponsive status. High p21 levels in sepsis patients correlated with low IFN-β expression, and p21 knockdown in human monocytes corroborated its role in IFN-β regulation. The data demonstrate that p21 adjusts the equilibrium between p65-p50 and p50-p50 NF-κB pathways to mediate macrophage plasticity in LPS tolerance. Identifying p21-related pathways involved in monocyte reprogramming may lead to potential targets for sepsis treatment. PMID:27427981

50. Photograph of a line drawing. 'AREA B, GENERAL ASSEMBLY, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

50. Photograph of a line drawing. 'AREA B, GENERAL ASSEMBLY, BUILDINGS I, J, L, & M - LINES 9 & 10.' Holston Army Ammunition Plant. March 13, 1967; revised November 15, 1967, January 3, 1968. Delineator: Unknown. Drawing # 7651-1009.454. - Holston Army Ammunition Plant, RDX-and-Composition-B Manufacturing Line 9, Kingsport, Sullivan County, TN

Appearance of metastable B2 phase during solidification of Ni 50 Zr 50 alloy: electrostatic levitation and molecular dynamics simulation studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Quirinale, D. G.; Rustan, G. E.; Wilson, S. R.

2015-02-04

High-energy x-ray diffraction measurements of undercooled, electrostatically levitated Ni 50Zr 50 liquid droplets were performed. The observed solidification pathway proceeded through the nucleation and growth of the metastable B2 phase, which persisted for several seconds before the rapid appearance of the stable B33 phase. This sequence is shown to be consistent with predictions from classical nucleation theory using data obtained from molecular dynamics (MD) simulations. A plausible mechanism for the B2–B33 transformation is proposed and investigated through further MD simulations.

The effects of aircraft (B-52) overflights on ancient structures

NASA Astrophysics Data System (ADS)

Battis, J. C.

1994-03-01

To simulate combat missions for the American bomber force, the Air Combat Command conducts low altitude training flights along routes throughout the U.S.A. This paper presents the results of an effort to evaluate the effect of these overflights on the many archaeologically significant structures located beneath the training routes. This study has shown that: (1) low overflights can induce measurable vibrations in these ancient structures; (2) the overflight induced motions do not constitute an appreciable threat to the sites; and (3) the observed levels of motion are no greater than those induced by sources in the natural environment. Although these findings are specific to overflights by B-52s, comparison of the low frequency acoustic signature of the B-52 and that of the B-1B overflights should not pose a significantly greater threat to the structures than B-52 overflights.

Occurrence of the structural enterocin A, P, B, L50B genes in enterococci of different origin.

PubMed

Strompfová, Viola; Lauková, Andrea; Simonová, Monika; Marcináková, Miroslava

2008-12-10

Enterococci are well-known producers of antimicrobial peptides--bacteriocins (enterocins) and the number of characterized enterocins has been significantly increased. Recently, enterocins are of great interest for their potential as biopreservatives in food or feed while research on enterocins as alternative antimicrobials in humans and animals is only at the beginning. The present study provides a survey about the occurrence of enterocin structural genes A, P, B, L50B in a target of 427 strains of Enterococcus faecium (368) and Enterococcus faecalis (59) species from different sources (animal isolates, food and feed) performed by PCR method. Based on our results, 234 strains possessed one or more enterocin structural gene(s). The genes of enterocin P and enterocin A were the most frequently detected structural genes among the PCR positive strains (170 and 155 strains, respectively). Different frequency of the enterocin genes occurrence was detected in strains according to their origin; the strains from horses and silage showed the highest frequency of enterocin genes presence. All possible combinations of the tested genes occurred at least twice except the combination of the gene of enterocin B and L50B which possessed neither strain. The gene of enterocin A was exclusively detected among E. faecium strains, while the gene of enterocin P, B, L50B were detected in strains of both species E. faecium and E. faecalis. In conclusion, a high-frequency and variability of enterocin structural genes exists among enterococci of different origin what offers a big possibility to find effective bacteriocin-producing strains for their application in veterinary medicine.

Nuclear Posture Review

DTIC Science & Technology

2018-02-01

SLBM); land- based intercontinental ballistic missiles (ICBM); and strategic bombers carrying gravity bombs and air-launched cruise missiles (ALCMs...capable bomber force beginning in the mid-2020s. The B83-1 and B61-11 gravity bombs can hold at risk a variety of protected targets. As a result...both will be retained in the stockpile, at least until there is sufficient confidence in the B61-12 gravity bomb that will be available in 2020

Identification of a major 50-kDa molecular weight human B-cell growth factor with Tac antigen-inducing activity on B cells.

PubMed

Kawano, M; Matsushima, K; Oppenheim, J J

1987-08-01

A bioassay was developed using human small B cells adherent to anti-human IgM (anti-mu)-coated wells. These B cells were stimulated to proliferate by culture supernatants of concanavalin A (Con A)-activated human peripheral blood lymphocytes (Con A Sup) even in the presence of high concentrations of anti-mu coated on assay wells. Human B-cell growth factor (BCGF) activities were partially purified from Con A Sup. Preparative chromatography (Sephacryl S-200 and isoelectrofocusing) yielded a major peak of BCGF activity for B cells adherent to anti-mu-coated wells with a molecular weight of 50,000 (50 kDa) and a pI 7.6. The 50-kDa BCGF was further purified by sequential chromatography using DEAE-Sephacel, CM-Sepharose, Sephacryl S-200, CM-high performance liquid chromatography (HPLC), and hydroxyapatite (HA)-HPLC. The HA-HPLC-purified 50-kDa BCGF was free of interleukin-1 (IL-1), interleukin-2 (IL-2), and interferon activities, but could support growth of BCL1 cells, similar to BCGF-II. Neither IL-1 nor interferon-gamma had any growth-stimulating effect in our B-cell proliferation assay with or without BCGF in Iscove's synthetic assay medium. BCGF-induced proliferation of B cells adherent to anti-mu-coated wells could be markedly augmented by the simultaneous or sequential addition of recombinant human IL-2 (rIL-2). When cultured for 3 days with 50-kDa BCGF, about 40% of B cells adherent to anti-mu-coated wells expressed Tac antigen, and monoclonal anti-Tac antibody inhibited rIL-2 enhancement of proliferation of 50-kDa BCGF-preactivated B cells. In addition, 50-kDa BCGF could induce Tac antigen on an Epstein-Barr virus-transformed B-cell line (ORSON) in the presence of a suboptimal dose of phorbol myristate acetate (PMA) and also on a natural killer-like cell line (YT cells). We have therefore identified a major 50-kDa BCGF activity with Tac antigen-inducing activity that also has a synergistic effect with IL-2 on normal B-cell proliferation.

Low Yield Nuclear Experiments: Should They Be Permitted Within a Comprehensive Test Ban Treaty?

DTIC Science & Technology

1996-10-01

GRAVITY BOMB 83 AF A W87 ICBM REENTRY VEHICLE 86 AF A W88 SLBM REENTRY VEHICLE 89 NAVY C SAFETY FEATURES: A--(ENDS, IHE, FRP) B--(ENDS, IHE) C--(ENDS) o...NUCLEAR WEAPON DELIVERY PLATFORMS (NUCLEAR POSTURE REVIEW) STRATEGIC DELIVERY VEHICLES 20 B-2 BOMBERS USAF 66 B-52 BOMBERS USAF 500/450 MINUTEMAN III...ICBMs USAF 14 TRIBENT SUBMARINES USN W/ 24 D-5 MISSILES EACH TACTICAL DELIVERY VEHICLES DUAL CAPABLE AIRCRAFT USAF/USN SEA-LAUNCH CRUISE MISSILES USN

Increased p50/p50 NF-κB Activation in Human Papillomavirus Type 6- or Type 11-Induced Laryngeal Papilloma Tissue

PubMed Central

Vancurova, Ivana; Wu, Rong; Miskolci, Veronika; Sun, Shishinn

2002-01-01

We have observed elevated NF-κB DNA-binding activity in nuclear extracts from human papillomavirus type 6- and 11-infected laryngeal papilloma tissues. The predominant DNA-binding species is the p50/p50 homodimer. The elevated NF-κB activity could be correlated with a reduced level of cytoplasmic IκBβ and could be associated with the overexpression of p21CIP1/WAF1 in papilloma cells. Increased NF-κB activity and cytoplasmic accumulation of p21CIP1/WAF1 might counteract death-promoting effects elicited by overexpressed PTEN and reduced activation of Akt and STAT3 previously noted in these tissues. PMID:11773428

Post-Cold War East Asia: A Geopolitical Overview With Recommendations for U.S. Force Posture

DTIC Science & Technology

2015-04-01

Its transition to institutional democracy was marked by assertive rhetoric and exploratory moves toward independence.21 From President Lee Teng-hui’s...accessed 18 April 2015). 59. Warren Strobel , “U.S. B-2 bombers sent to Korea on rare mission: diplomacy not destruction,” Reuters, 30 March 2013, http...Solomon, Jonathan F. “Demystifying Conventional Deterrence.” Strategic Studies Quarterly (Winter 2013): 117-157. Strobel , Warren. “U.S. B-2 bombers

B-70 Aircraft Study. Volume 2

NASA Technical Reports Server (NTRS)

1972-01-01

Volume 2 of the final report on the B-70 aircraft study is presented here. The B-70 Program, at the onset, was a full weapon system capable of sustained Mach 3 flight for the major portion of its design missions. The weapon system was to enter the SAC inventory as an RS-70 with the first intercontinental resonnaissance/bomber wing scheduled to go operational in July, 1964. After several redirections, a two XB-70 air vehicle program emerged with its prime objective being to demonstrate the technical feasibility of sustained Mach 3 flight. This section describes the original Weapon System 110A concepts, the evolution of the RS-70 design, and the XB-70 air vehicles which demonstrated the design, fabrication, and technical feasibility of long range Mach 3 flights at high altitude. The data presented shows that a very large step forward in the state-of-the-art of manned aircraft design was achieved during the B-70 development program and that advances were made and incorporated in every area, including design, materials application, and manufacturing techniques.

Specific features of thermal and magnetic properties of Yb B50 at low temperatures

NASA Astrophysics Data System (ADS)

Novikov, V. V.; Zhemoedov, N. A.; Matovnikov, A. V.; Mitroshenkov, N. V.; Popova, E. A.; Tolstosheev, A. K.; Malkin, B. Z.; Bud'ko, S. L.

2018-05-01

Heat capacity, thermal expansion, and magnetization of ytterbium boride Yb B50 were studied at temperatures 0.6-300 K, 5-300 K, and 2-300 K, respectively. We revealed two smooth peaks at about 4.0 and 60 K in the temperature dependence of the heat capacity. A comparison with the heat capacity of the diamagnetic isostructural boride Lu B50 shows that these anomalies can be attributed to excitations in the ytterbium sublattice (Schottky anomalies). A scheme for splitting of the ground F 7 /2 2 multiplet of Y b3 + ions in the crystal field is proposed. Reliability of the proposed crystal-field energies of the Y b3 + ions is confirmed by the analysis of temperature dependencies of magnetic susceptibility and magnetization in applied magnetic fields up to 55 kOe. A clear anisotropy of the thermal expansion and a negative expansion within a wide temperature range (40-185 K) were observed. Assuming that this anomaly of the thermal expansion in higher borides is caused by the specific thermal evolution of a crystal lattice observed earlier, in particular, in Lu B50 , and the interaction of rare-earth ions with lattice strains, we have determined phenomenological Grüneisen parameters which characterize effects due to thermal transitions of Y b3 + ions between the ground and excited states. A phase transition of Yb B50 to any magnetically ordered state was not observed down to the lowest temperatures of experiments.

Developing Tools to Counteract and Prevent Suicide Bomber Incidents: A Case Study in Value Sensitive Design.

PubMed

Royakkers, Lambèr; Steen, Marc

2017-08-01

Developers and designers make all sorts of moral decisions throughout an innovation project. In this article, we describe how teams of developers and designers engaged with ethics in the early phases of innovation based on case studies in the SUBCOP project (SUBCOP stands for 'SUicide Bomber COunteraction and Prevention'). For that purpose, Value Sensitive Design (VSD) will be used as a reference. Specifically, we focus on the following two research questions: How can researchers/developers learn about users' perspectives and values during the innovation process? and How can researchers/developers take into account these values, and related design criteria, in their decision-making during the innovation process? Based on a case study of several innovation processes in this project, we conclude the researchers/developers involved are able to do something similar to VSD (without them knowing about VSD or calling it 'VSD'), supported by relatively simple exercises in the project, e.g., meetings with potential end-users and discussions with members of the Ethical Advisory Board of the project. Furthermore, we also found-possibly somewhat counterintuitively-that a commercial, with its focus on understanding and satisfying customers' needs, can promote VSD.

26 CFR 1.50B-2 - Electing small business corporations.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 1 2011-04-01 2009-04-01 true Electing small business corporations. 1.50B-2... business corporations. (a) General rule—(1) In general. In the case of an electing small business... be apportioned separately. In determining who are shareholders of an electing small business...

26 CFR 1.50B-2 - Electing small business corporations.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Electing small business corporations. 1.50B-2... business corporations. (a) General rule—(1) In general. In the case of an electing small business... be apportioned separately. In determining who are shareholders of an electing small business...

Crystal structures and compressibility of novel iron borides Fe{sub 2}B{sub 7} and Fe{sub x}B{sub 50} synthesized at high pressure and high temperature

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bykova, E., E-mail: elena.bykova@uni-bayreuth.de; Laboratory of Crystallography, University of Bayreuth, D-95440 Bayreuth; Gou, H.

2015-10-15

We present here a detailed description of the crystal structures of novel iron borides, Fe{sub 2}B{sub 7} and Fe{sub x}B{sub 50} with various iron content (x=1.01(1), 1.04(1), 1.32(1)), synthesized at high pressures and high temperatures. As revealed by high-pressure single-crystal X-ray diffraction, the structure of Fe{sub 2}B{sub 7} possesses short incompressible B–B bonds, which make it as stiff as diamond in one crystallographic direction. The volume compressibility of Fe{sub 2}B{sub 7} (the bulk modulus K{sub 0}= 259(1.8) GPa, K{sub 0}′= 4 (fixed)) is even lower than that of FeB{sub 4} and comparable with that of MnB{sub 4}, known for highmore » bulk moduli among 3d metal borides. Fe{sub x}B{sub 50} adopts the structure of the tetragonal δ-B, in which Fe atoms occupy an interstitial position. Fe{sub x}B{sub 50} does not show considerable anisotropy in the elastic behavior. - Graphical abstract: Crystal structures of novel iron borides, Fe{sub 2}B{sub 7} and Fe{sub x}B{sub 50} (x=1.01(1), 1.04(1), 1.32(1)). - Highlights: • Novel iron borides, Fe{sub 2}B{sub 7} and Fe{sub x}B{sub 50}, were synthesized under HPHT conditions. • Fe{sub 2}B{sub 7} has a unique orthorhombic structure (space group Pbam). • Fe{sub 2}B{sub 7} possesses short incompressible B–B bonds that results in high bulk modulus. • Fe{sub x}B{sub 50} adopts the structure of the tetragonal δ-B composed of B{sub 12} icosahedra. • In Fe{sub x}B{sub 50} intraicosahedral bonds are stiffer than intericosahedral ones.« less

Hepatitis B: 50 years after the discovery of Australia antigen.

PubMed

Lok, A Suk-Fong

2016-01-01

It is an honour to be invited to recount the progress in our understanding and management of hepatitis B 50 years after the discovery of Australia antigen (Au Ag). During this half century, we have gone from identifying the causative agent--hepatitis B virus (HBV), understanding its biology and the disease it causes, to having vaccines that can prevent HBV infection and antiviral therapy that can suppress HBV replication and prevent progression of HBV-related liver disease. As a result of the progress, prevalence of HBV infection and morbidity and mortality from chronic HBV infection has declined. © 2015 John Wiley & Sons Ltd.

50 CFR Table 3b to Part 680 - Crab Disposition or Product Codes

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Crab Disposition or Product Codes 3b Table 3b to Part 680 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) SHELLFISH FISHERIES OF THE EXCLUSIVE ECONOMIC...

Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency.

PubMed

Fliegauf, Manfred; Bryant, Vanessa L; Frede, Natalie; Slade, Charlotte; Woon, See-Tarn; Lehnert, Klaus; Winzer, Sandra; Bulashevska, Alla; Scerri, Thomas; Leung, Euphemia; Jordan, Anthony; Keller, Baerbel; de Vries, Esther; Cao, Hongzhi; Yang, Fang; Schäffer, Alejandro A; Warnatz, Klaus; Browett, Peter; Douglass, Jo; Ameratunga, Rohan V; van der Meer, Jos W M; Grimbacher, Bodo

2015-09-03

Common variable immunodeficiency (CVID), characterized by recurrent infections, is the most prevalent symptomatic antibody deficiency. In ∼90% of CVID-affected individuals, no genetic cause of the disease has been identified. In a Dutch-Australian CVID-affected family, we identified a NFKB1 heterozygous splice-donor-site mutation (c.730+4A>G), causing in-frame skipping of exon 8. NFKB1 encodes the transcription-factor precursor p105, which is processed to p50 (canonical NF-κB pathway). The altered protein bearing an internal deletion (p.Asp191_Lys244delinsGlu; p105ΔEx8) is degraded, but is not processed to p50ΔEx8. Altered NF-κB1 proteins were also undetectable in a German CVID-affected family with a heterozygous in-frame exon 9 skipping mutation (c.835+2T>G) and in a CVID-affected family from New Zealand with a heterozygous frameshift mutation (c.465dupA) in exon 7. Given that residual p105 and p50—translated from the non-mutated alleles—were normal, and altered p50 proteins were absent, we conclude that the CVID phenotype in these families is caused by NF-κB1 p50 haploinsufficiency. Copyright © 2015 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

United States Air Force Annual Financial Statement 2011

DTIC Science & Technology

2011-01-01

is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources , gathering and maintaining...defenses. The B-52 Stratofortress is a long-range, nuclear and conventional heavy bomber that can perform a variety of missions. The bomber can fly...of the United States Government are deposited. Exceptions include receipts from specific sources required by law to be deposited into other

McDonald XP-85 Airplane in 40x80 foot Wind Tunnel.

NASA Image and Video Library

1948-04-08

Front View of McDonald XP-85 Plan Model. Parasite Airplane designed to be carried in the B-36 bombay (never built) At the time it was the smallest Jet powered airplane. The McDonnell XF-85 Goblin was an American prototype fighter aircraft conceived during World War II by McDonnell Aircraft. It was intended to be deployed from the bomb bay of the giant Convair B-36 bomber as a parasite fighter. The XF-85's intended role was to defend bombers from hostile interceptor aircraft, a need demonstrated during World War II

DNA Binding and Phosphorylation Regulate the Core Structure of the NF-κB p50 Transcription Factor

NASA Astrophysics Data System (ADS)

Vonderach, Matthias; Byrne, Dominic P.; Barran, Perdita E.; Eyers, Patrick A.; Eyers, Claire E.

2018-06-01

The NF-κB transcription factors are known to be extensively phosphorylated, with dynamic site-specific modification regulating their ability to dimerize and interact with DNA. p50, the proteolytic product of p105 (NF-κB1), forms homodimers that bind DNA but lack intrinsic transactivation function, functioning as repressors of transcription from κB promoters. Here, we examine the roles of specific phosphorylation events catalysed by either protein kinase A (PKAc) or Chk1, in regulating the functions of p50 homodimers. LC-MS/MS analysis of proteolysed p50 following in vitro phosphorylation allows us to define Ser328 and Ser337 as PKAc- and Chk1-mediated modifications, and pinpoint an additional four Chk1 phosphosites: Ser65, Thr152, Ser242 and Ser248. Native mass spectrometry (MS) reveals Chk1- and PKAc-regulated disruption of p50 homodimer formation through Ser337. Additionally, we characterise the Chk1-mediated phosphosite, Ser242, as a regulator of DNA binding, with a S242D p50 phosphomimetic exhibiting a > 10-fold reduction in DNA binding affinity. Conformational dynamics of phosphomimetic p50 variants, including S242D, are further explored using ion-mobility MS (IM-MS). Finally, comparative theoretical modelling with experimentally observed p50 conformers, in the absence and presence of DNA, reveals that the p50 homodimer undergoes conformational contraction during electrospray ionisation that is stabilised by complex formation with κB DNA.

DNA Binding and Phosphorylation Regulate the Core Structure of the NF-κB p50 Transcription Factor.

PubMed

Vonderach, Matthias; Byrne, Dominic P; Barran, Perdita E; Eyers, Patrick A; Eyers, Claire E

2018-06-05

The NF-κB transcription factors are known to be extensively phosphorylated, with dynamic site-specific modification regulating their ability to dimerize and interact with DNA. p50, the proteolytic product of p105 (NF-κB1), forms homodimers that bind DNA but lack intrinsic transactivation function, functioning as repressors of transcription from κB promoters. Here, we examine the roles of specific phosphorylation events catalysed by either protein kinase A (PKA c ) or Chk1, in regulating the functions of p50 homodimers. LC-MS/MS analysis of proteolysed p50 following in vitro phosphorylation allows us to define Ser328 and Ser337 as PKA c - and Chk1-mediated modifications, and pinpoint an additional four Chk1 phosphosites: Ser65, Thr152, Ser242 and Ser248. Native mass spectrometry (MS) reveals Chk1- and PKA c -regulated disruption of p50 homodimer formation through Ser337. Additionally, we characterise the Chk1-mediated phosphosite, Ser242, as a regulator of DNA binding, with a S242D p50 phosphomimetic exhibiting a > 10-fold reduction in DNA binding affinity. Conformational dynamics of phosphomimetic p50 variants, including S242D, are further explored using ion-mobility MS (IM-MS). Finally, comparative theoretical modelling with experimentally observed p50 conformers, in the absence and presence of DNA, reveals that the p50 homodimer undergoes conformational contraction during electrospray ionisation that is stabilised by complex formation with κB DNA. Graphical Abstract ᅟ.

50 CFR Table 14b to Part 679 - Port of Landing Codes: Non-Alaska

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Port of Landing Codes: Non-Alaska 14b... ALASKA Pt. 679, Table 14b Table 14b to Part 679—Port of Landing Codes: Non-Alaska (California, Canada... report a landing at a location not currently assigned a location code number, use the code for “Other...

50 CFR Table 14b to Part 679 - Port of Landing Codes: Non-Alaska

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Port of Landing Codes: Non-Alaska 14b... ALASKA Pt. 679, Table 14b Table 14b to Part 679—Port of Landing Codes: Non-Alaska (California, Canada... report a landing at a location not currently assigned a location code number, use the code for “Other...

HATS-50b through HATS-53b: Four Transiting Hot Jupiters Orbiting G-type Stars Discovered by the HATSouth Survey

NASA Astrophysics Data System (ADS)

Henning, Th.; Mancini, L.; Sarkis, P.; Bakos, G. Á.; Hartman, J. D.; Bayliss, D.; Bento, J.; Bhatti, W.; Brahm, R.; Ciceri, S.; Csubry, Z.; de Val-Borro, M.; Espinoza, N.; Fulton, B. J.; Howard, A. W.; Isaacson, H. T.; Jordán, A.; Marcy, G. W.; Penev, K.; Rabus, M.; Suc, V.; Tan, T. G.; Tinney, C. G.; Wright, D. J.; Zhou, G.; Durkan, S.; Lazar, J.; Papp, I.; Sari, P.

2018-02-01

We report the discovery of four close-in transiting exoplanets (HATS-50b through HATS-53b), discovered using the HATSouth three-continent network of homogeneous and automated telescopes. These new exoplanets belong to the class of hot Jupiters and orbit G-type dwarf stars, with brightness in the range V = 12.5–14.0 mag. While HATS-53 has many physical characteristics similar to the Sun, the other three stars appear to be metal-rich ([{Fe}/{{H}}]=0.2{--}0.3), larger, and more massive. Three of the new exoplanets, namely HATS-50b, HATS-51b, and HATS-53b, have low density (HATS-50b: 0.39+/- 0.10 {M}{{J}}, 1.130+/- 0.075 {R}{{J}}; HATS-51b: 0.768+/- 0.045 {M}{{J}}, 1.41+/- 0.19 {R}{{J}}; HATS-53b: 0.595+/- 0.089 {M}{{J}}, 1.340+/- 0.056 {R}{{J}}) and similar orbital periods (3.8297 days, 3.3489 days, 3.8538 days, respectively). Instead, HATS-52b is more dense (mass 2.24+/- 0.15 {M}{{J}} and radius 1.382+/- 0.086 {R}{{J}}) and has a shorter orbital period (1.3667 days). It also receives an intensive radiation from its parent star and, consequently, presents a high equilibrium temperature ({T}{eq}=1834+/- 73 K). HATS-50 shows a marginal additional transit feature consistent with an ultra-short-period hot super Neptune (upper mass limit 0.16 {M}{{J}}), which will be able to be confirmed with TESS photometry. The HATSouth network is operated by a collaboration consisting of Princeton University (PU), the Max Planck Institute für Astronomie (MPIA), the Australian National University (ANU), and the Pontificia Universidad Católica de Chile (PUC). The station at Las Campanas Observatory (LCO) of the Carnegie Institute is operated by PU in conjunction with PUC, the station at the High Energy Spectroscopic Survey (H.E.S.S.) site is operated in conjunction with MPIA, and the station at Siding Spring Observatory (SSO) is operated jointly with ANU. Based in part on observations made with the ESO 3.6 m, the NTT, the MPG 2.2 m and Euler 1.2 m Telescopes at the ESO Observatory in

Dioxonaphthoimidazoliums AB1 and YM155 disrupt phosphorylation of p50 in the NF-κB pathway

PubMed Central

Chin, Tan Min; Go, Mei Lin

2016-01-01

The NF-κB pathway is overexpressed in non-small cell lung cancers (NSCLC) and contributes to the poor prognosis and high mortality characterizing this malignancy. Silencing the p50 and p65 NF-κB subunits in the NSCLC H1299 cell line led to profound loss in cell viability and downregulated anti-apoptotic proteins survivin and Mcl1. We also showed that a survivin suppressant, the dioxonaphthoimidazolium YM155, and its structural analog AB1 arrested the growth of H1299 cells at nanomolar concentrations. Both compounds were apoptogenic and suppressed survivin and other anti-apoptotic proteins (Mcl1, Bcl-2, Bcl-xl) in a dose- and/or time-dependent manner. YM155 and AB1 did not affect the expression of key proteins (IκBα, p65, p50) involved in NF-κB signaling. Stable IκBα levels suggest that the NF-κB/IκB complex and proteins upstream of IκBα, were not targeted. Neither did the compounds intercept the nuclear translocation of the p50 and p65 subunits. On the other hand, YM155 and AB1 suppressed the phosphorylation of the p50 subunit at Ser337 which is critical in promoting the binding of NF-κB dimers to DNA. Both compounds duly impeded the binding of NF-κB dimers to DNA and attenuated transcriptional activity of luciferase-transfected HEK293 cells controlled by NF-κB response elements. We propose that the “silencing” the NF-κB pathway effected by these compounds contributed to their potent apoptogenic effects on H1299. Notwithstanding, the mechanism(s) involved in their ability to abolish phosphorylation of p50 remains to be elucidated. Taken together, these results disclose a novel facet of functionalized dioxonaphthoimidazoliums that could account for their potent cell killing property. PMID:26872379

X-1E launch from B-50 mothership

NASA Technical Reports Server (NTRS)

1950-01-01

Beginning in 1946, two XS-1 experimental research aircraft (later redesignated X-1s) conducted pioneering tests at Muroc Army Air Field (now Edwards Air Force Base) in California to obtain flight data on conditions in the transonic speed range. These early tests culminated on October 14, 1947, in the first piloted flight faster than Mach 1.0, the speed of sound. During November, 1947, the Air Force authorized studies that led to a contract (W-33-038-ac-20062) with Bell Aircraft to build four (later three) improved X-1 aircraft (the X-1C being cancelled). Designated X-1A (#48-1384), X-1B (#48-1385), and X-1D (#48-1386), the airplanes were ready by late 1950. The aircraft were about five feet longer and 2,500 lbs. heavier than the original X-craft planes. They used the 8-percent wing like the earlier X-craft. The D-model had a low-pressure turbo-pump and the B model was fitted with a prototype hydrogen peroxide reaction control system for later aircraft to use in exoatmospheric research flights. Access was through a lift-off canopy. The planes were finished in their bare metal color and white. The X-1D was ready first, but on what was intended to be its second flight (August 22, 1951) it was jettisoned and crashed at Muroc after an aerial explosion while still mated to its mother (B-50A [#46-006A]) ship. The long-delayed X-1 #3 airplane with the turbine pump was finally completed for the NACA in 1951. It made its first glide flight on July 20, 1951, with NACA pilot Joseph Cannon. Its second and final captive flight was on November 9, 1951. It was destroyed on the ground by an explosion and fire along with its B-50A mother ship while attempting to jettison fuel. The X-1A arrived at Muroc in January, 1953 and had its first powered flight on February 21, 1953. On December 8, 1953 with Yeager as pilot, the aircraft investigated high-speed stability and control issues. The X-1A was turned over to the NACA, but was lost to aerial explosion on August 8, 1955, shortly before

B(E2)↑ Measurements for Radioactive Neutron-Rich Ge Isotopes: Reaching the N=50 Closed Shell

NASA Astrophysics Data System (ADS)

Padilla-Rodal, E.; Galindo-Uribarri, A.; Baktash, C.; Batchelder, J. C.; Beene, J. R.; Bijker, R.; Brown, B. A.; Castaños, O.; Fuentes, B.; del Campo, J. Gomez; Hausladen, P. A.; Larochelle, Y.; Lisetskiy, A. F.; Mueller, P. E.; Radford, D. C.; Stracener, D. W.; Urrego, J. P.; Varner, R. L.; Yu, C.-H.

2005-03-01

The B(E2;0+1→2+1) values for the radioactive neutron-rich germanium isotopes 78,80Ge and the closed neutron shell nucleus 82Ge were measured at the HRIBF using Coulomb excitation in inverse kinematics. These data allow a study of the systematic trend between the subshell closures at N=40 and 50. The B(E2) behavior approaching N=50 is similar to the trend observed for heavier isotopic chains. A comparison of the experimental results with a shell model calculation demonstrates persistence of the N=50 shell gap and a strong sensitivity of the B(E2) values to the effective interaction.

Production of enterocins L50A, L50B, and IT, a new enterocin, by Enterococcus faecium IT62, a strain isolated from Italian ryegrass in Japan.

PubMed

Izquierdo, Esther; Bednarczyk, Audrey; Schaeffer, Christine; Cai, Yimin; Marchioni, Eric; Van Dorsselaer, Alain; Ennahar, Saïd

2008-06-01

Enterococcus faecium IT62, isolated from ryegrass in Japan, was shown to produce three different bacteriocins, two of which had molecular masses and amino acid sequences that corresponded to those of enterocin L50A and enterocin L50B. These peptides existed, however, as chemically modified forms that were either N formylated or N formylated and oxidized at Met(24). The third bacteriocin, named enterocin IT, had a molecular mass of 6,390 Da, was made up of 54 amino acids, and did not correspond to any known bacteriocin. However, enterocin IT was identical to the C-terminal part of the 16-amino-acid-longer bacteriocin 32 (T. Inoue, H. Tomita, and Y. Ike, Antimicrob. Agents Chemother., 50:1202-1212, 2006). For the first time, the antimicrobial activity spectra for enterocins L50A and L50B were determined separately and included a wide range of gram-positive bacteria but also a few gram-negative strains that were weakly sensitive. Slight differences in the activities of enterocins L50A and L50B were observed, as gram-positive bacteria showed an overall higher level of sensitivity to L50A than to L50B, as opposed to gram-negative ones. Conversely, enterocin IT showed a very narrow antimicrobial spectrum that was limited to E. faecium strains, one strain of Bacillus subtilis, and one strain of Lactococcus lactis. This study showed that E. faecium IT62, a grass-borne strain, produces bacteriocins with very different activity features and structures that may be found in strains associated with food or those of clinical origin, which demonstrates that a particular enterocin structure may be widespread and not related to the producer's origin.

Production of Enterocins L50A, L50B, and IT, a New Enterocin, by Enterococcus faecium IT62, a Strain Isolated from Italian Ryegrass in Japan▿

PubMed Central

Izquierdo, Esther; Bednarczyk, Audrey; Schaeffer, Christine; Cai, Yimin; Marchioni, Eric; Van Dorsselaer, Alain; Ennahar, Saïd

2008-01-01

Enterococcus faecium IT62, isolated from ryegrass in Japan, was shown to produce three different bacteriocins, two of which had molecular masses and amino acid sequences that corresponded to those of enterocin L50A and enterocin L50B. These peptides existed, however, as chemically modified forms that were either N formylated or N formylated and oxidized at Met24. The third bacteriocin, named enterocin IT, had a molecular mass of 6,390 Da, was made up of 54 amino acids, and did not correspond to any known bacteriocin. However, enterocin IT was identical to the C-terminal part of the 16-amino-acid-longer bacteriocin 32 (T. Inoue, H. Tomita, and Y. Ike, Antimicrob. Agents Chemother., 50:1202-1212, 2006). For the first time, the antimicrobial activity spectra for enterocins L50A and L50B were determined separately and included a wide range of gram-positive bacteria but also a few gram-negative strains that were weakly sensitive. Slight differences in the activities of enterocins L50A and L50B were observed, as gram-positive bacteria showed an overall higher level of sensitivity to L50A than to L50B, as opposed to gram-negative ones. Conversely, enterocin IT showed a very narrow antimicrobial spectrum that was limited to E. faecium strains, one strain of Bacillus subtilis, and one strain of Lactococcus lactis. This study showed that E. faecium IT62, a grass-borne strain, produces bacteriocins with very different activity features and structures that may be found in strains associated with food or those of clinical origin, which demonstrates that a particular enterocin structure may be widespread and not related to the producer's origin. PMID:18391036

30 CFR 50.20-5 - Criteria-MSHA Form 7000-1, Section B.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., INJURIES, ILLNESSES, EMPLOYMENT, AND PRODUCTION IN MINES NOTIFICATION, INVESTIGATION, REPORTS AND RECORDS OF ACCIDENTS, INJURIES, ILLNESSES, EMPLOYMENT, AND COAL PRODUCTION IN MINES Reporting of Accidents, Injuries, and Illnesses § 50.20-5 Criteria—MSHA Form 7000-1, Section B. (a) This section shall be completed...

30 CFR 50.20-5 - Criteria-MSHA Form 7000-1, Section B.

Code of Federal Regulations, 2014 CFR

2014-07-01

..., INJURIES, ILLNESSES, EMPLOYMENT, AND PRODUCTION IN MINES NOTIFICATION, INVESTIGATION, REPORTS AND RECORDS OF ACCIDENTS, INJURIES, ILLNESSES, EMPLOYMENT, AND COAL PRODUCTION IN MINES Reporting of Accidents, Injuries, and Illnesses § 50.20-5 Criteria—MSHA Form 7000-1, Section B. (a) This section shall be completed...

30 CFR 50.20-5 - Criteria-MSHA Form 7000-1, Section B.

Code of Federal Regulations, 2013 CFR

2013-07-01

..., INJURIES, ILLNESSES, EMPLOYMENT, AND PRODUCTION IN MINES NOTIFICATION, INVESTIGATION, REPORTS AND RECORDS OF ACCIDENTS, INJURIES, ILLNESSES, EMPLOYMENT, AND COAL PRODUCTION IN MINES Reporting of Accidents, Injuries, and Illnesses § 50.20-5 Criteria—MSHA Form 7000-1, Section B. (a) This section shall be completed...

30 CFR 50.20-5 - Criteria-MSHA Form 7000-1, Section B.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., INJURIES, ILLNESSES, EMPLOYMENT, AND PRODUCTION IN MINES NOTIFICATION, INVESTIGATION, REPORTS AND RECORDS OF ACCIDENTS, INJURIES, ILLNESSES, EMPLOYMENT, AND COAL PRODUCTION IN MINES Reporting of Accidents, Injuries, and Illnesses § 50.20-5 Criteria—MSHA Form 7000-1, Section B. (a) This section shall be completed...

32 CFR Appendix B to Part 50 - Overseas Life Insurance Registration Program

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Overseas Life Insurance Registration Program B... Part 50—Overseas Life Insurance Registration Program A. Registration Criteria 1. Initial Registration a. Insurers must demonstrate continuous successful operation in the life insurance business for a period of...

32 CFR Appendix B to Part 50 - Overseas Life Insurance Registration Program

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Overseas Life Insurance Registration Program B... Part 50—Overseas Life Insurance Registration Program A. Registration Criteria 1. Initial Registration a. Insurers must demonstrate continuous successful operation in the life insurance business for a period of...

50. Neg. No. F176B, Jun 5, 1936, EXTERIORFORD ASSEMBLY PLANT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

50. Neg. No. F-176B, Jun 5, 1936, EXTERIOR-FORD ASSEMBLY PLANT AT LONG BEACH, OVERALL VIEW OF PLANT FROM THE HENRY FORD BRIDGE, CERRITOS CHANNEL IN THE FOREGROUND - Ford Motor Company Long Beach Assembly Plant, Assembly Building, 700 Henry Ford Avenue, Long Beach, Los Angeles County, CA

46 CFR 35.01-50 - Special operating requirements for tank barges carrying certain dangerous bulk cargoes-B/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... certain dangerous bulk cargoes-B/ALL. 35.01-50 Section 35.01-50 Shipping COAST GUARD, DEPARTMENT OF... requirements for tank barges carrying certain dangerous bulk cargoes—B/ALL. (a) The requirements of this... times. (f) During the time the cargo tanks contain dangerous cargoes described in paragraph (a) of this...

46 CFR 35.01-50 - Special operating requirements for tank barges carrying certain dangerous bulk cargoes-B/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

... certain dangerous bulk cargoes-B/ALL. 35.01-50 Section 35.01-50 Shipping COAST GUARD, DEPARTMENT OF... requirements for tank barges carrying certain dangerous bulk cargoes—B/ALL. (a) The requirements of this... times. (f) During the time the cargo tanks contain dangerous cargoes described in paragraph (a) of this...

46 CFR 35.01-50 - Special operating requirements for tank barges carrying certain dangerous bulk cargoes-B/ALL.

Code of Federal Regulations, 2012 CFR

2012-10-01

... certain dangerous bulk cargoes-B/ALL. 35.01-50 Section 35.01-50 Shipping COAST GUARD, DEPARTMENT OF... Special operating requirements for tank barges carrying certain dangerous bulk cargoes—B/ALL. (a) The... closed and secured at all times. (f) During the time the cargo tanks contain dangerous cargoes described...

46 CFR 35.01-50 - Special operating requirements for tank barges carrying certain dangerous bulk cargoes-B/ALL.

Code of Federal Regulations, 2014 CFR

2014-10-01

... certain dangerous bulk cargoes-B/ALL. 35.01-50 Section 35.01-50 Shipping COAST GUARD, DEPARTMENT OF... Special operating requirements for tank barges carrying certain dangerous bulk cargoes—B/ALL. (a) The... closed and secured at all times. (f) During the time the cargo tanks contain dangerous cargoes described...

46 CFR 35.01-50 - Special operating requirements for tank barges carrying certain dangerous bulk cargoes-B/ALL.

Code of Federal Regulations, 2013 CFR

2013-10-01

... certain dangerous bulk cargoes-B/ALL. 35.01-50 Section 35.01-50 Shipping COAST GUARD, DEPARTMENT OF... Special operating requirements for tank barges carrying certain dangerous bulk cargoes—B/ALL. (a) The... closed and secured at all times. (f) During the time the cargo tanks contain dangerous cargoes described...

10 CFR Appendix B to Part 50 - Quality Assurance Criteria for Nuclear Power Plants and Fuel Reprocessing Plants

Code of Federal Regulations, 2011 CFR

2011-01-01

... 10 Energy 1 2011-01-01 2011-01-01 false Quality Assurance Criteria for Nuclear Power Plants and... LICENSING OF PRODUCTION AND UTILIZATION FACILITIES Pt. 50, App. B Appendix B to Part 50—Quality Assurance... report a description of the quality assurance program to be applied to the design, fabrication...

Chinese-English Aviation and Space Dictionary

DTIC Science & Technology

1973-04-01

i.e., individual characters with re- duced numbers of strokes. this process is in effect eroding the traditional classification of a character by its...side rod 17 b X1&jt d aolyu- edge effect 18 birajie boundary; border; bound; 19 frontier; ,nd binJie jiaoy’,; .iý K! M narginal checking 20 bianjie...range missile; 23 very-long-range missile chaoynianchegb oghli151 .’ . long-range bomber; global 24 bomber; superbomber chaoyue h mhshu 14

Lack of NF-kappaB p50 exacerbates degeneration of hippocampal neurons after chemical exposure and impairs learning.

PubMed

Kassed, C A; Willing, A E; Garbuzova-Davis, S; Sanberg, P R; Pennypacker, K R

2002-08-01

The roles of activated NF-kappaB subunits in the CNS remain to be discerned. Members of this family of transcription factors are essential to diverse physiological processes and can be activated by pathogens, stress, pharmacological agents, and trauma. We are particularly interested in long-term NF-kappaB activation and its involvement in neuroplastic changes in the brain resulting from acquisition of memory as well as injury. Here, we use lesioning by the limbic-specific neurotoxicant trimethyltin (TMT) as a model in which to examine activation of the NF-kappaB p50 subunit before, during, and after neuronal degeneration. Neurons in wild-type mice that survived TMT-induced injury contained activated p50 and did not label with Fluoro-Jade, a histochemical marker of degenerating neurons. Granule cells of the wild-type dentate gyrus subregion, an area particularly vulnerable to TMT-induced degeneration, contained less activated p50 protein than CA regions. We compared the extent of degeneration in wild-type and p50-null mice and found a fivefold increase in death of hippocampal neurons in mice lacking p50. The hippocampus is key to processes of learning and memory, and NF-kappaB has reported involvement in these processes. The enhanced hippocampal degeneration in p50-null mice prompted us to evaluate their basal learning abilities, and we discovered that difficulties in task acquisition were an additional consequence of p50 ablation. These results indicate that absence of p50 negatively modulates learning ability as well as hippocampal responsiveness to brain injury after a chemical-induced lesion.

Magnetostructural transitions and magnetocaloric effects in Ni50Mn35In14.25B0.75 ribbons

NASA Astrophysics Data System (ADS)

Pandey, Sudip; Quetz, Abdiel; Ibarra-Gaytan, P. J.; Sánchez-Valdés, C. F.; Aryal, Anil; Dubenko, Igor; Sanchez Llamazares, Jose Luis; Stadler, Shane; Ali, Naushad

2018-05-01

The structural, thermal, and magnetic behaviors, as well as the martensitic phase transformation and related magnetocaloric response of Ni50Mn35In14.25B0.75 annealed ribbons have been investigated using room-temperature X-ray diffraction (XRD), differential scanning calorimetry (DSC), and magnetization measurements. Ni50Mn35In14.25B0.75 annealed ribbons show a sharper change in magnetization at the martensitic transition, resulting in larger magnetic entropy changes in comparison to bulk Ni50Mn35In14.25B0.75. A drastic shift in the martensitic transformation temperature (TM) of 70 K to higher temperature was observed for the annealed ribbons relative to that of the bulk (TM = 240 K). The results obtained for magnetic, thermal, structural, and magnetocaloric properties of annealed ribbons have been compared to those of the corresponding bulk alloys.

Spectroscopy of 50Sc and ab initio calculations of B (M 3 ) strengths

NASA Astrophysics Data System (ADS)

Garnsworthy, A. B.; Bowry, M.; Olaizola, B.; Holt, J. D.; Stroberg, S. R.; Cruz, S.; Georges, S.; Hackman, G.; MacLean, A. D.; Measures, J.; Patel, H. P.; Pearson, C. J.; Svensson, C. E.

2017-10-01

The GRIFFIN spectrometer at TRIUMF-ISAC has been used to study excited states and transitions in 50Sc following the β decay of 50Ca. Branching ratios were determined from the measured γ -ray intensities, and angular correlations of γ rays have been used to firmly assign the spins of excited states. The presence of an isomeric state that decays by an M 3 transition with a B (M 3 ) strength of 13.6(7) W.u. has been confirmed. We compare the first ab initio calculations of B (M 3 ) strengths in light- and medium-mass nuclei from the valence-space in-medium similarity renormalization group approach, using consistently derived effective Hamiltonians and effective M 3 operator. The experimental data are well reproduced for isoscalar M 3 transitions when using bare g factors, but the strength of isovector M 3 transitions are found to be underestimated by an order of magnitude.

15 CFR Appendix B to Subpart K of... - Line Representing the 50-Fathom Isobath Surrounding Cordell Bank

Code of Federal Regulations, 2013 CFR

2013-01-01

... 15 Commerce and Foreign Trade 3 2013-01-01 2013-01-01 false Line Representing the 50-Fathom Isobath Surrounding Cordell Bank B Appendix B to Subpart K of Part 922 Commerce and Foreign Trade... Cordell Bank National Marine Sanctuary Pt. 922, Subpt. K, App. B Appendix B to Subpart K of Part 922—Line...

15 CFR Appendix B to Subpart K of... - Line Representing the 50-Fathom Isobath Surrounding Cordell Bank

Code of Federal Regulations, 2010 CFR

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Line Representing the 50-Fathom Isobath Surrounding Cordell Bank B Appendix B to Subpart K of Part 922 Commerce and Foreign Trade... Cordell Bank National Marine Sanctuary Pt. 922, Subpt. K, App. B Appendix B to Subpart K of Part 922—Line...

15 CFR Appendix B to Subpart K of... - Line Representing the 50-Fathom Isobath Surrounding Cordell Bank

Code of Federal Regulations, 2014 CFR

2014-01-01

... 15 Commerce and Foreign Trade 3 2014-01-01 2014-01-01 false Line Representing the 50-Fathom Isobath Surrounding Cordell Bank B Appendix B to Subpart K of Part 922 Commerce and Foreign Trade... Cordell Bank National Marine Sanctuary Pt. 922, Subpt. K, App. B Appendix B to Subpart K of Part 922—Line...

15 CFR Appendix B to Subpart K of... - Line Representing the 50-Fathom Isobath Surrounding Cordell Bank

Code of Federal Regulations, 2012 CFR

2012-01-01

... 15 Commerce and Foreign Trade 3 2012-01-01 2012-01-01 false Line Representing the 50-Fathom Isobath Surrounding Cordell Bank B Appendix B to Subpart K of Part 922 Commerce and Foreign Trade... Cordell Bank National Marine Sanctuary Pt. 922, Subpt. K, App. B Appendix B to Subpart K of Part 922—Line...

15 CFR Appendix B to Subpart K of... - Line Representing the 50-Fathom Isobath Surrounding Cordell Bank

Code of Federal Regulations, 2011 CFR

2011-01-01

... 15 Commerce and Foreign Trade 3 2011-01-01 2011-01-01 false Line Representing the 50-Fathom Isobath Surrounding Cordell Bank B Appendix B to Subpart K of Part 922 Commerce and Foreign Trade... Cordell Bank National Marine Sanctuary Pt. 922, Subpt. K, App. B Appendix B to Subpart K of Part 922—Line...

Novel insights into the role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells

PubMed Central

Bortolotto, Valeria; Grilli, Mariagrazia

2017-01-01

Within the CNS nuclear factor-kappa B (NF-κB) transcription factors are involved in a wide range of functions both in homeostasis and in pathology. Over the years, our and other groups produced a vast array of information on the complex involvement of NF-κB proteins in different aspects of postnatal neurogenesis. In particular, several extracellular signals and membrane receptors have been identified as being able to affect neural progenitor cells (NPC) and their progeny via NF-κB activation. A crucial role in the regulation of neuronal fate specification in adult hippocampal NPC is played by the NF-κB p50 subunit. NF-κB p50KO mice display a remarkable reduction in adult hippocampal neurogenesis which correlates with a selective defect in hippocampal-dependent short-term memory. Moreover absence of NF-κB p50 can profoundly affect the in vitro proneurogenic response of adult hippocampal NPC (ahNPC) to several endogenous signals and drugs. Herein we briefly review the current knowledge on the pivotal role of NF-κB p50 in the regulation of adult hippocampal neurogenesis. In addition we discuss more recent data that further extend the relevance of NF-κB p50 to novel astroglia-derived signals which can influence neuronal specification of ahNPC and to astrocyte-NPC cross-talk. PMID:28469638

50 CFR 216.16 - Prohibitions under the General Authorization for Level B harassment for scientific research.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Prohibitions under the General Authorization for Level B harassment for scientific research. 216.16 Section 216.16 Wildlife and Fisheries... Prohibitions under the General Authorization for Level B harassment for scientific research. It shall be...

50 CFR 216.16 - Prohibitions under the General Authorization for Level B harassment for scientific research.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Prohibitions under the General Authorization for Level B harassment for scientific research. 216.16 Section 216.16 Wildlife and Fisheries... Prohibitions under the General Authorization for Level B harassment for scientific research. It shall be...

The Specificity of Innate Immune Responses Is Enforced by Repression of Interferon Response Elements by NF-κB p50

PubMed Central

Cheng, Christine S.; Feldman, Kristyn E.; Lee, James; Verma, Shilpi; Huang, De-Bin; Huynh, Kim; Chang, Mikyoung; Ponomarenko, Julia V.; Sun, Shao-Cong; Benedict, Chris A.; Ghosh, Gourisankar; Hoffmann, Alexander

2011-01-01

The specific binding of transcription factors to cognate sequence elements is thought to be critical for the generation of specific gene expression programs. Members of the nuclear factor κB (NF-κB) and interferon (IFN) regulatory factor (IRF) transcription factor families bind to the κB site and the IFN response element (IRE), respectively, of target genes, and they are activated in macrophages after exposure to pathogens. However, how these factors produce pathogen-specific inflammatory and immune responses remains poorly understood. Combining top-down and bottom-up systems biology approaches, we have identified the NF-κB p50 homodimer as a regulator of IRF responses. Unbiased genome-wide expression and biochemical and structural analyses revealed that the p50 homodimer repressed a subset of IFN-inducible genes through a previously uncharacterized subclass of guanine-rich IRE (G-IRE) sequences. Mathematical modeling predicted that the p50 homodimer might enforce the stimulus specificity of composite promoters. Indeed, the production of the antiviral regulator IFN-β was rendered stimulus-specific by the binding of the p50 homodimer to the G-IRE–containing IFNβ enhancer to suppress cytotoxic IFN signaling. Specifically, a deficiency in p50 resulted in the inappropriate production of IFN-β in response to bacterial DNA sensed by Toll-like receptor 9. This role for the NF-κB p50 homodimer in enforcing the specificity of the cellular response to pathogens by binding to a subset of IRE sequences alters our understanding of how the NF-κB and IRF signaling systems cooperate to regulate antimicrobial immunity. PMID:21343618

26 CFR 1.50B-1 - Definitions of WIN expenses and WIN employees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... employee. (c) Trade or business expenses. The term “WIN expenses” includes only salaries and wages which... 26 Internal Revenue 1 2010-04-01 2010-04-01 true Definitions of WIN expenses and WIN employees. 1... INCOME TAXES Rules for Computing Credit for Expenses of Work Incentive Programs § 1.50B-1 Definitions of...

Biochemical and Genetic Evidence that Enterococcus faecium L50 Produces Enterocins L50A and L50B, the sec-Dependent Enterocin P, and a Novel Bacteriocin Secreted without an N-Terminal Extension Termed Enterocin Q

PubMed Central

Cintas, Luis M.; Casaus, Pilar; Herranz, Carmen; Håvarstein, Leiv Sigve; Holo, Helge; Hernández, Pablo E.; Nes, Ingolf F.

2000-01-01

Enterococcus faecium L50 grown at 16 to 32°C produces enterocin L50 (EntL50), consisting of EntL50A and EntL50B, two unmodified non-pediocin-like peptides synthesized without an N-terminal leader sequence or signal peptide. However, the bacteriocin activity found in the cell-free culture supernatants following growth at higher temperatures (37 to 47°C) is not due to EntL50. A purification procedure including cation-exchange, hydrophobic interaction, and reverse-phase liquid chromatography has shown that the antimicrobial activity is due to two different bacteriocins. Amino acid sequences obtained by Edman degradation and DNA sequencing analyses revealed that one is identical to the sec-dependent pediocin-like enterocin P produced by E. faecium P13 (L. M. Cintas, P. Casaus, L. S. Håvarstein, P. E. Hernández, and I. F. Nes, Appl. Environ. Microbiol. 63:4321–4330, 1997) and the other is a novel unmodified non-pediocin-like bacteriocin termed enterocin Q (EntQ), with a molecular mass of 3,980. DNA sequencing analysis of a 963-bp region of E. faecium L50 containing the enterocin P structural gene (entP) and the putative immunity protein gene (entiP) reveals a genetic organization identical to that previously found in E. faecium P13. DNA sequencing analysis of a 1,448-bp region identified two consecutive but diverging open reading frames (ORFs) of which one, termed entQ, encodes a 34-amino-acid protein whose deduced amino acid sequence was identical to that obtained for EntQ by amino acid sequencing, showing that EntQ, similarly to EntL50A and EntL50B, is synthesized without an N-terminal leader sequence or signal peptide. The second ORF, termed orf2, was located immediately upstream of and in opposite orientation to entQ and encodes a putative immunity protein composed of 221 amino acids. Bacteriocin production by E. faecium L50 showed that EntP and EntQ are produced in the temperature range from 16 to 47°C and maximally detected at 47 and 37 to 47�

B-52 Testing F-111 Parachute

NASA Technical Reports Server (NTRS)

1988-01-01

The main parachute begins to deploy on the mock-up of an F-111 'Aardvark' bomber cockpit section after being dropped from NASA's B-52 mothership during 1988 flight tests on improved parachute systems for the Air Force bomber. The F-111's ejection system separated the entire cockpit from the rest of the aircraft, and a large parachute was then deployed to lower the cockpit section to the ground. NASA B-52, Tail Number 008, is an air launch carrier aircraft, 'mothership,' as well as a research aircraft platform that has been used on a variety of research projects. The aircraft, a 'B' model built in 1952 and first flown on June 11, 1955, is the oldest B-52 in flying status and has been used on some of the most significant research projects in aerospace history. Some of the significant projects supported by B-52 008 include the X-15, the lifting bodies, HiMAT (highly maneuverable aircraft technology), Pegasus, validation of parachute systems developed for the space shuttle program (solid-rocket-booster recovery system and the orbiter drag chute system), and the X-38. The B-52 served as the launch vehicle on 106 X-15 flights and flew a total of 159 captive-carry and launch missions in support of that program from June 1959 to October 1968. Information gained from the highly successful X-15 program contributed to the Mercury, Gemini, and Apollo human spaceflight programs as well as space shuttle development. Between 1966 and 1975, the B-52 served as the launch aircraft for 127 of the 144 wingless lifting body flights. In the 1970s and 1980s, the B-52 was the launch aircraft for several aircraft at what is now the Dryden Flight Research Center, Edwards, California, to study spin-stall, high-angle-of attack, and maneuvering characteristics. These included the 3/8-scale F-15/spin research vehicle (SRV), the HiMAT (Highly Maneuverable Aircraft Technology) research vehicle, and the DAST (drones for aerodynamic and structural testing). The aircraft supported the development of

Future Shock: A Case for the B-2 Bomber

DTIC Science & Technology

1994-06-01

Defense Nuclear Facilities Panel of the Committee on Armed Services, 102d Cong., 2d sess., 1992, 369 3 Ibid, 64. 4 Ibid, 320. 6 Chapter 2 The...Options For The 1990s: Hearings before the Defense Policy Panel and the Department of Energy Defense Nuclear Facilities Panel of the Committee on Armed...Department of Energy Defense Nuclear Facilities Panel of the Committee on Armed Services, 102d Cong., 2d sess., 1992, p. 241. 43 Ibid. 44 Although

50 CFR Table 2b to Part 660... - 2014, and Beyond, Allocations by Species or Species Group

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false 2014, and Beyond, Allocations by Species or Species Group 2b Table 2b to Part 660, Subpart C Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OFF...

Different effects of antisense RelA p65 and NF-kappaB1 p50 oligonucleotides on the nuclear factor-kappaB mediated expression of ICAM-1 in human coronary endothelial and smooth muscle cells.

PubMed

Voisard, R; Huber, N; Baur, R; Susa, M; Ickrath, O; Both, A; Koenig, W; Hombach, V

2001-01-01

Activation of nuclear factor-kappaB (NF-kappaB) is one of the key events in early atherosclerosis and restenosis. We hypothesized that tumor necrosis factor-alpha (TNF-alpha) induced and NF-kappaB mediated expression of intercellular adhesion molecule-1 (ICAM-1) can be inhibited by antisense RelA p65 and NF-kappaB1 p50 oligonucleotides (RelA p65 and NF-kappaB1 p50). Smooth muscle cells (SMC) from human coronary plaque material (HCPSMC, plaque material of 52 patients), SMC from the human coronary media (HCMSMC), human endothelial cells (EC) from umbilical veins (HUVEC), and human coronary EC (HCAEC) were successfully isolated (HCPSMC, HUVEC), identified and cultured (HCPSMC, HCMSMC, HUVEC, HCAEC). 12 hrs prior to TNF-alpha stimulus (20 ng/mL, 6 hrs) RelA p65 and NF-kappaB1 p50 (1, 2, 4, 10, 20, and 30 microM) and controls were added for a period of 18 hrs. In HUVEC and HCAEC there was a dose dependent inhibition of ICAM-1 expression after adding of both RelA p65 and NF-kappaB1 p50. No inhibitory effect was seen after incubation of HCMSMC with RelA p65 and NF-kappaB1 p50. A moderate inhibition of ICAM-1 expression was found after simultaneous addition of RelA p65 and NF-kappaB1 p50 to HCPSMC, no inhibitory effect was detected after individual addition of RelA p65 and NF-kappaB1 p50. The data point out that differences exist in the NF-kappaB mediated expression of ICAM-1 between EC and SMC. Experimental antisense strategies directed against RelA p65 and NF-kappaB1 p50 in early atherosclerosis and restenosis are promising in HCAEC but will be confronted with redundant pathways in HCMSMC and HCPSMC.

Overwhelming Force, Indecisive Victory: The German Invasion of Yugoslavia, 1941

DTIC Science & Technology

1993-05-13

It was a system of large units that depended primarily on animal draft power for transportation that resulted in low march speed and lack of...STUBOL* 12 3D BOMBER REGT SKOPLJE* 13 63D BOMBER GROUP PZTROVAC 30 D017 13 64TH BOMBER GROUP PSTROVAC 30 DOl0 14 5TH FIGHTER RIGT NIS* 15 35TH...FIGHTER GROUP KOSANCIC 15 HAWKER FURY 16 36TH FIGHTER GROUP REZANOVACKA KOSA 15 HAWKER FURY 17 4TH BOMBER AIR BDE LJUBIC* 18 1ST BOMBER RIGT NOVI SAD* 19

50 CFR Figures 19a and 19b to Part... - Chauvin Shrimp Deflector Installation Details

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false Chauvin Shrimp Deflector Installation Details 19a Figures 19a and 19b to Part 223 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE MARINE MAMMALS THREATENED MARINE...

Role of the p50 subunit of NF-κB in vitamin E-induced changes in mice treated with the peroxisome proliferator, ciprofibrate

PubMed Central

Calfee-Mason, Karen G.; Lee, Eun Y.; Spear, Brett T.; Glauert, Howard P.

2008-01-01

Peroxisome proliferators (PPs) are a diverse class of chemicals, which cause a dramatic increase in the size and number of hepatic peroxisomes in rodents and eventually lead to the development of hepatic tumors. Nuclear factor-κB (NF-κB) is a transcription factor activated by reactive oxygen and is involved in cell proliferation and apoptosis. Previously we found that the peroxisome proliferator ciprofibrate (CIP) activates NF-κB and that dietary vitamin E decreases CIP-induced NF-κB DNA binding. We therefore hypothesized that inhibition of NF-κB by vitamin E is necessary for effects of vitamin E on CIP-induced cell proliferation and the inhibition of apoptosis by CIP. Sixteen B6129 female mice (p50+/+) and twenty mice deficient in the p50 subunit of NF-κB (p50−/−) were fed a purified diet containing 10 or 250 mg/kg vitamin E (α-tocopherol acetate) for 28 days. At that time, half of the mice were placed on the same diet with 0.01% CIP for 10 days. CIP treatment increased the DNA binding activity of NF-κB and cell proliferation, but had no significant effect on apoptosis. Compared to wild-type mice, the p50−/− mice had lower NF-κB activation, higher basal levels of cell proliferation and apoptosis, and a lower ratio of reduced glutathione to oxidized glutathione (GSH/GSSG). There was approximately a 60% reduction in cell proliferation in the CIP-treated p50−/− mice fed higher vitamin E in comparison to the p50−/− mice fed lower vitamin E. Dietary vitamin E also inhibited the DNA binding activity of NF-κB, increased apoptosis, and increased the GSH/GSSG ratio. This study shows the effects of vitamin E on cell growth parameters do not appear to be solely through decreased NF-κB activation, suggesting that vitamin E is acting by other molecular mechanisms. PMID:18336980

Lockheed F-94B Starfire at the NASA Lewis Research Center

NASA Image and Video Library

1959-12-21

A Lockheed F-94B Starfire on the hangar apron at the National Aeronautics and Space Administration (NASA) Lewis Research Center in Cleveland, Ohio. The Air Force contracted Lockheed in November 1948 to create the new F-94s fighters. The first test flight occurred only months later in April 1949. This quick turnaround was due to the fact that the F-94 was based largely on the TF-80 fighter and constructed with parts from the P-80, including its two General Electric I-40 turbojet engines. The F-94Bs entered the Korean War in late 1951, but were initially prevented from flying over enemy territory due to fear that their fire control system would be copied by the enemy if an F-94B went down. The Starfire went on to perform scores of missions escorting B-29 and B-26 bombers deep into enemy territory and acting as interceptors against enemy fighters. In mid-1954 the F-94s were retired from active military service. Lewis acquired the F-94B Starfire in April 1956. At the time, the aircraft industry was preparing for the first use of jet engines for commercial aviation. The amount of noise generated by the engines was a major obstacle. Lewis undertook an extensive program to understand the causes of the noise and develop methods for reducing it. This program included the study of aerodynamic sound at high speed and altitude using the F-94B.

Distinct roles of NF-{kappa}B p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dambach, Donna M.; Pharmaceutical Research Institute, Bristol-Myers Squibb, Princeton, NJ 08543; Durham, Stephen K.

2006-03-01

Oxidative stress plays an important role in acetaminophen (APAP)-induced hepatotoxicity. In addition to inducing direct cellular damage, oxidants can activate transcription factors including NF-{kappa}B, which regulate the production of inflammatory mediators implicated in hepatotoxicity. Here, we investigated the role of APAP-induced oxidative stress and NF-{kappa}B in inflammatory mediator production. Treatment of mice with APAP (300 mg/kg, i.p.) resulted in centrilobular hepatic necrosis and increased serum aminotransferase levels. This was correlated with depletion of hepatic glutathione and CuZn superoxide dismutase (SOD). APAP administration also increased expression of the proinflammatory mediators, interleukin-1{beta} (IL-1{beta}), tumor necrosis factor-{alpha} (TNF{alpha}), macrophage chemotactic protein-1 (MCP-1), andmore » KC/gro, and the anti-inflammatory cytokine, interleukin-10 (IL-10). Pretreatment of mice with the antioxidant, N-acetylcysteine (NAC) prevented APAP-induced depletion of glutathione and CuZnSOD, as well as hepatotoxicity. NAC also abrogated APAP-induced increases in TNF{alpha}, KC/gro, and IL-10, but augmented expression of the anti-inflammatory cytokines interleukin-4 (IL-4) and transforming growth factor-{beta} (TGF{beta}). No effects were observed on IL-1{beta} or MCP-1 expression. To determine if NF-{kappa}B plays a role in regulating mediator production, we used transgenic mice with a targeted disruption of the gene for NF-{kappa}B p50. As observed with NAC pretreatment, the loss of NF-{kappa}B p50 was associated with decreased ability of APAP to upregulate TNF{alpha}, KC/gro, and IL-10 expression and increased expression of IL-4 and TGF{beta}. However, in contrast to NAC pretreatment, the loss of p50 had no effect on APAP-induced hepatotoxicity. These data demonstrate that APAP-induced cytokine expression in the liver is influenced by oxidative stress and that this is dependent, in part, on NF-{kappa}B. However, NF-{kappa}B p50

1, 25(OH){sub 2}D{sub 3}-induced interaction of vitamin D receptor with p50 subunit of NF-κB suppresses the interaction between KLF5 and p50, contributing to inhibition of LPS-induced macrophage proliferation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Dong; School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063000; Zhang, Ruo-nan

KLF5 and nuclear factor κB (NF-κB) regulate cell proliferation and inflammation. Vitamin D signaling through vitamin D receptor (VDR) exerts anti-proliferative and anti-inflammatory actions. However, an actual relationship between KLF5, NF-κB and VDR in the inflammation and proliferation of macrophages is still unclear. Here, we showed that LPS and proinflammatory cytokines stimulate KLF5 gene expression in macrophages, and that 1, 25(OH){sub 2}D{sub 3} suppresses LPS-induced KLF5 expression and cell proliferation via upregulation of VDR expression. Mechanistic studies suggested that KLF5 interacts with p50 subunit of NF-κB to cooperatively induce the expressions of positive cell cycle regulators cyclin B1 and Cdk1/Cdc2more » in LPS-treated macrophages. Further studies revealed that 1, 25(OH){sub 2}D{sub 3}-induced interaction of VDR with p50 decreases LPS-induced interaction of KLF5 with p50. Collectively, we identify a novel regulatory pathway in which 1, 25(OH){sub 2}D{sub 3} induces VDR expression and promotes VDR interaction with p50 subunit of NF-κB, which in turn attenuates the association of KLF5 with p50 subunit of NF-κB and thus exerts anti-inflammatory and anti-proliferative effects on macrophages. - Highlights: • 1, 25(OH){sub 2}D{sub 3} suppresses LPS-induced KLF5 expression via upregulation of VDR expression. • KLF5 interacts with NF-κB-p50 to cooperatively induce the expressions of positive cell cycle regulators cyclin B1 and Cdk1/Cdc2 in LPS-treated macrophages. • 1,25(OH){sub 2}D{sub 3} induces interaction of VDR with p50.« less

Antimicrobial activities of bacteriocins E50-52 and B602 against MRSA and other nosocomial infections

USDA-ARS?s Scientific Manuscript database

Our objective was to determine the antimicrobial activities of previously published bacteriocins E50-52 and B602 against methicillin resistant Staphylococcus aureus (MRSA) and other prominent nosocomial bacterial infections. methods: Several Russian hospitals were enlisted into the study from 2003 ...

46 CFR 151.50-50 - Elemental phosphorus in water.

Code of Federal Regulations, 2012 CFR

2012-10-01

.... (b) When a water displacement method of discharge is used, pressure vessel type cargo tanks, designed... 46 Shipping 5 2012-10-01 2012-10-01 false Elemental phosphorus in water. 151.50-50 Section 151.50... phosphorus in water. (a) Tanks shall be designed and tested for a head equivalent to the design lading of...

IAU Resolution 2009 B5 - Commission 50 Draft Action Plan - Presentation and Discussion

NASA Astrophysics Data System (ADS)

Green, R. F.

2015-03-01

IAU Resolution 2009 B5 calls on IAU members to protect the public's right to an unpolluted night sky as well as the astronomical quality of the sky around major research observatories. The multi-pronged approach of Commission 50 includes working with the lighting industry for appropriate products from the solid state revolution, arming astronomers with training and materials for presentation, selective endorsement of key protection issues, cooperation with several other IAU commissions for education and outreach, and provision of clear quantitative priorities for outdoor lighting standards.

Stealth Aircraft Technology. (Latest Citations from the Aerospace Database)

NASA Technical Reports Server (NTRS)

1995-01-01

The bibliography contains citations concerning design, manufacture, and history of aircraft incorporating stealth technology. Citations focus on construction materials, testing, aircraft performance, and technology assessment. Fighter aircraft, bombers, missiles, and helicopters represent coverage. (Contains 50-250 citations and includes a subject term index and title list.)

50 CFR Table 1b to Part 660... - 2013, Allocations by Species or Species Group (Weights in Metric Tons)

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false 2013, Allocations by Species or Species Group (Weights in Metric Tons) 1b Table 1b to Part 660, Subpart C Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED...

Précis of the myth of martyrdom: what really drives suicide bombers, rampage shooters, and other self-destructive killers.

PubMed

Lankford, Adam

2014-08-01

For years, scholars have claimed that suicide terrorists are not suicidal, but rather psychologically normal individuals inspired to sacrifice their lives for an ideological cause, due to a range of social and situational factors. I agree that suicide terrorists are shaped by their contexts, as we all are. However, I argue that these scholars went too far. In The Myth of Martyrdom: What Really Drives Suicide Bombers, Rampage Shooters, and Other Self-Destructive Killers, I take the opposing view, based on my in-depth analyses of suicide attackers from Asia, Africa, Europe, the Middle East, and North America; attackers who were male, female, young, old, Islamic, and Christian; attackers who carried out the most deadly and the least deadly strikes. I present evidence that in terms of their behavior and psychology, suicide terrorists are much like others who commit conventional suicides, murder-suicides, or unconventional suicides where mental health problems, personal crises, coercion, fear of an approaching enemy, or hidden self-destructive urges play a major role. I also identify critical differences between suicide terrorists and those who have genuinely sacrificed their lives for a greater good. By better understanding suicide terrorists, experts in the behavioral and brain sciences may be able to pioneer exciting new breakthroughs in security countermeasures and suicide prevention. And even more ambitiously, by examining these profound extremes of the human condition, perhaps we can more accurately grasp the power of the human survival instinct among those who are actually psychologically healthy.

Protective protein/cathepsin A down-regulates osteoclastogenesis by associating with and degrading NF-kappaB p50/p65.

PubMed

Masuhara, Masaaki; Sato, Takuya; Hada, Naoto; Hakeda, Yoshiyuki

2009-01-01

Disruption of the cooperative function balance between osteoblasts and osteoclasts causes various bone disorders, some of which are attributed to abnormal osteoclast recruitment. Osteoclast differentiation is dependent on the receptor activator of nuclear factor (NF)-kappaB ligand (RANKL) as well as the macrophage colony-stimulating factor. The osteoclast formation induced by cytokines requires activation of NF-kappaB, AP-1 and nuclear factor of activated T cells c1. However, osteoclasts are not the only cell types that express these transcription factors, suggesting that some unknown molecules specific for osteoclasts may associate with the transcription factors. Here, we explored the possibility of molecules binding directly to NF-kappaB and cloned protective protein/cathepsin A (PPCA) by yeast two-hybrid screening using a cDNA library of osteoclast precursors. Forced expression of PPCA with p50/p65 in HEK293 cells decreased both the level of p50/p65 proteins and the transcriptional activity. Abundant PPCA was detected in the lysosomes of the transfected HEK293 cells, but a small amount of this enzyme was also present in the cytosolic fraction. In addition, over-expression of PPCA caused the disappearance of p50/p65 in both the lysosomal and cytosolic fractions. PPCA was expressed throughout osteoclastogenesis, and the expression was slightly up-regulated by RANKL signaling. Knockdown of PPCA in osteoclast precursors with PPCA siRNA stimulated binding of nuclear proteins to oligonucleotides containing an NF-kappaB binding motif and increased osteoclastogenesis. Our present results indicate a novel role for PPCA in osteoclastogenesis via down-regulation of NF-kappaB activity and suggest a new function for PPCA as an NF-kappaB-degrading enzyme in addition to its known multifunctional properties.

GENERAL VIEW OF THE FINAL PRODUCTION LINE OF THE FIRST ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF THE FINAL PRODUCTION LINE OF THE FIRST B-29 SHOWING THE LINK-BELT CONVEYOR SYSTEM AND WOOD BLOCK FLOORING. WHO, 1944 - Offutt Air Force Base, Glenn L. Martin-Nebraska Bomber Plant, Building D, Peacekeeper Drive, Bellevue, Sarpy County, NE

Temperature of aircraft cargo flame exposure during accidents involving fuel spills

NASA Astrophysics Data System (ADS)

Mansfield, J. A.

1993-01-01

This report describes an evaluation of flame exposure temperatures of weapons contained in alert (parked) bombers due to accidents that involve aircraft fuel fires. The evaluation includes two types of accident: collisions into an alert aircraft by an aircraft that is on landing or take-off; and engine start accidents. Both the B-1B and B-52 alert aircraft are included in the evaluation.

Temperature of aircraft cargo flame exposure during accidents involving fuel spills

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mansfield, J.A.

1993-01-01

This report describes an evaluation of flame exposure temperatures of weapons contained in alert (parked) bombers due to accidents that involve aircraft fuel fires. The evaluation includes two types of accident, collisions into an alert aircraft by an aircraft that is on landing or take-off, and engine start accidents. Both the B-1B and B-52 alert aircraft are included in the evaluation.

Realistic Bomber Training Initiative Supplemental Environmental Impact Statement

DTIC Science & Technology

2007-03-01

mph at the surface and 27 mph at 22 feet AGL; e ) A pull-up maneuver by the B-1B, which may be executed once or twice per sortie- operation, can...avoid resources, where feasible. ( e ) Developing and implementing site-specifi.c mitigation measures, if required. (3) The Air Force will avoid or...form a complete MOA, the LancerMOA. (2) Concerns were expressed about the structw~ e of the proposed MTR, IR 178. The Air Force reduced noise

Forecasting Flying Hour Costs of the B-1, B-2, and the B-52 Bomber Aircraft

DTIC Science & Technology

2008-03-01

reject the null hypothesis that the residuals are normally distributed. Likewise, in the Breusch Pagan test , a p-value greater than 0.05 means we...normality or constant variance, it will be noted in the results tables in Chapter IV. The Shapiro Wilk and Breusch Pagan tests are also very...the model; and • the results of the Shapiro Wilk, Breusch Pagan , and Durbin Watson tests . Summary This chapter outlines the methodology used in

Sustaining the U.S. Air Force Nuclear Mission

DTIC Science & Technology

2013-01-01

B61 -7 B83 B61 -11 B-2 NC3 ITW Tornado F-16...F-15E MMIII W78 W87 Mk-12A Mk-21 B61 -3/4 Gravity bomb: Tactical delivery Long- range standoff ICBM Gravity bomb: Strategic delivery 6...1 Follow-on ALCM B61 -7 B83 B61 -11 Next generation bomber NC3 ITW F-35 New GBSD Follow-on to W87/W78 Next generation fuse B61 -3/4 Gravity

Air and Space Power Journal. Volume 24, Number 2, Summer 2010

DTIC Science & Technology

2010-01-01

25:30 PM Departments 20 ❙ Ricochets and Replies 23 ❙ Views & Analyses Should the United States Maintain the Nuclear Triad...become especially daunting. That is the environment I address in this article by examining a case study of the B-1B bomber nuclear -certification... nuclear certification before describing the situation I faced when I ar- rived at the B-1B System Program Office (SPO) in the summer of 1982. Then, I move

Crystal genes in a marginal glass-forming system of Ni 50Zr 50

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wen, T. Q.; Tang, L.; Sun, Y.

Glass-forming motifs with B2 traits are found. A perfect Ni-centered B33 motif deteriorates the glass-forming ability of Ni 50Zr 50. The marginal glass-forming ability (GFA) of binary Ni-Zr system is an issue to be explained considering the numerous bulk metallic glasses (BMGs) found in the Cu-Zr system. Using molecular dynamics, the structures and dynamics of Ni 50Zr 50 metallic liquid and glass are investigated at the atomistic level. To achieve a well-relaxed glassy sample, sub-T g annealing method is applied and the final sample is closer to the experiments than the models prepared by continuous cooling. With the state-of-the-art structuralmore » analysis tools such as cluster alignment and pair-wise alignment methods, two glass-forming motifs with some mixed traits of the metastable B2 crystalline phase and the crystalline Ni-centered B33 motif are found to be dominant in the undercooled liquid and glass samples. A new chemical order characterization on each short-range order (SRO) structure is accomplished based on the cluster alignment method. The significant amount of the crystalline motif and the few icosahedra in the glassy sample deteriorate the GFA.« less

Crystal genes in a marginal glass-forming system of Ni 50Zr 50

DOE PAGES

Wen, T. Q.; Tang, L.; Sun, Y.; ...

2017-10-17

Glass-forming motifs with B2 traits are found. A perfect Ni-centered B33 motif deteriorates the glass-forming ability of Ni 50Zr 50. The marginal glass-forming ability (GFA) of binary Ni-Zr system is an issue to be explained considering the numerous bulk metallic glasses (BMGs) found in the Cu-Zr system. Using molecular dynamics, the structures and dynamics of Ni 50Zr 50 metallic liquid and glass are investigated at the atomistic level. To achieve a well-relaxed glassy sample, sub-T g annealing method is applied and the final sample is closer to the experiments than the models prepared by continuous cooling. With the state-of-the-art structuralmore » analysis tools such as cluster alignment and pair-wise alignment methods, two glass-forming motifs with some mixed traits of the metastable B2 crystalline phase and the crystalline Ni-centered B33 motif are found to be dominant in the undercooled liquid and glass samples. A new chemical order characterization on each short-range order (SRO) structure is accomplished based on the cluster alignment method. The significant amount of the crystalline motif and the few icosahedra in the glassy sample deteriorate the GFA.« less

Specific solubilization of impurities in culture media: Arg solution improves purification of pH-responsive tag CspB50 with Teriparatide.

PubMed

Oki, Shogo; Nonaka, Takahiro; Shiraki, Kentaro

2018-06-01

Protein purification using non-chromatographic methods is a simple technique that avoids costly resin. Recently, a cell surface protein B (CspB) tag has been developed for a pH-responsive tag for protein purification by solid-liquid separation. Proteins fused with the CspB tag show reversible insolubilization at acidic pH that can be used in solid-liquid separation for protein purification. However, brown-color impurities from co-precipitation hamper further analysis of the target proteins. In this study, we investigated the effect of additives on the co-precipitation of CspB-tagged Teriparatide (CspB50TEV-Teriparatide) expressed in Corynebacterium glutamicum and associated impurities. Arginine (Arg) at 1.0 M was found to be the most effective additive for removing impurities, particularly carotenoids and nucleic acids. Furthermore, all impurities detected in the fluorescence and absorbance spectra were successfully removed by the repetition of precipitation-redissolution in the Arg solution. The precipitation yield of the CspB50TEV-Teriparatide did not change with the addition of Arg and the repetition of the precipitation-redissolution process. Collectively, our findings indicate that the specific desorption of π-electron rich compounds by Arg may be useful in conjunction with the pH-responsive CspB tag for solid-liquid protein purification. Copyright © 2018 Elsevier Inc. All rights reserved.

REMEDIATION OF A MAJOR JET FUEL SPILL BY BIOSLURPER AND NATURAL BIOVENTING TECHNOLOGY ON AN ISLAND AIR BASE

EPA Science Inventory

The Indian Ocean island of Diego Garcia has served as a base for B-52 bombers. In 1991 an underground transfer pipeline fracture was discovered after a spill exceeding 200,000 gallons occurred. The hydrogeology is fresh water at less than ten feet down overlying more dense salt...

DETAIL VIEW ABOVE THE MAIN ASSEMBLY LEVEL SHOWING HOIST AT ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

DETAIL VIEW ABOVE THE MAIN ASSEMBLY LEVEL SHOWING HOIST AT COLUMN LINE U-6 USED FOR LIFTING WING COMPONENTS FROM THE WING ASSEMBLY ANNEX TO THE B-29 PRODUCTION LINE. - Offutt Air Force Base, Glenn L. Martin-Nebraska Bomber Plant, Building D, Peacekeeper Drive, Bellevue, Sarpy County, NE

An Assessment of Media Coverage of the B-2 Stealth Bomber

DTIC Science & Technology

1990-01-01

15 Sharon M. Friedman, Carole M. Gorney, and Brenda P. Egolf, "Reporting on Radiation: A Content Analysis of Chernobyl Coverage," Journal of...Mitterrand," Political Science Quarterly, 39 (1987): 103-122. 1 29 Jane Blankenship, Serefa Mendez - Mendez , Jong Guen King and Joseph Giodan, "Initial... Carole M. Gorney and Brenda P. Egolf, "Reporting on Radiation: A Content Analysis of Chernobyl Coverage," Journal of Communication, Summer3 (1987

Expression of NF-κB p50 in Tumor Stroma Limits the Control of Tumors by Radiation Therapy

PubMed Central

Crittenden, Marka R.; Cottam, Benjamin; Savage, Talicia; Nguyen, Cynthia; Newell, Pippa; Gough, Michael J.

2012-01-01

Radiation therapy aims to kill cancer cells with a minimum of normal tissue toxicity. Dying cancer cells have been proposed to be a source of tumor antigens and may release endogenous immune adjuvants into the tumor environment. For these reasons, radiation therapy may be an effective modality to initiate new anti-tumor adaptive immune responses that can target residual disease and distant metastases. However, tumors engender an environment dominated by M2 differentiated tumor macrophages that support tumor invasion, metastases and escape from immune control. In this study, we demonstrate that following radiation therapy of tumors in mice, there is an influx of tumor macrophages that ultimately polarize towards immune suppression. We demonstrate using in vitro models that this polarization is mediated by transcriptional regulation by NFκB p50, and that in mice lacking NFκB p50, radiation therapy is more effective. We propose that despite the opportunity for increased antigen-specific adaptive immune responses, the intrinsic processes of repair following radiation therapy may limit the ability to control residual disease. PMID:22761754

History Microcomputer Games: Update 2.

ERIC Educational Resources Information Center

Sargent, James E.

1985-01-01

Provides full narrative reviews of B-1 Nuclear Bomber (Avalon, 1982); American History Adventure (Social Science Microcomputer Review Software, 1985); Government Simulations (Prentice-Hall, 1985); and The Great War, FDR and the New Deal, and Hitler's War, all from New Worlds Software, 1985. Lists additional information on five other history and…

Therapeutic Effect of Topical Administration of SN50, an Inhibitor of Nuclear Factor-κB, in Treatment of Corneal Alkali Burns in Mice

PubMed Central

Saika, Shizuya; Miyamoto, Takeshi; Yamanaka, Osamu; Kato, Tadashi; Ohnishi, Yoshitaka; Flanders, Kathleen C.; Ikeda, Kazuo; Nakajima, Yuji; Kao, Winston W.-Y.; Sato, Misako; Muragaki, Yasuteru; Ooshima, Akira

2005-01-01

We evaluated the therapeutic efficacy of topical administration of SN50, an inhibitor of nuclear factor-κB, in a corneal alkali burn model in mice. An alkali burn was produced with 1 N NaOH in the cornea of C57BL/6 mice under general anesthesia. SN50 (10 μg/μl) or vehicle was topically administered daily for up to 12 days. The eyes were processed for histological or immunohistochemical examination after bromodeoxyuridine labeling or for semiquantification of cytokine mRNA. Topical SN50 suppressed nuclear factor-κB activation in local cells and reduced the incidence of epithelial defects/ulceration in healing corneas. Myofibroblast generation, macrophage invasion, activity of matrix metalloproteinases, basement membrane destruction, and expression of cytokines were all decreased in treated corneas compared with controls. To elucidate the role of tumor necrosis factor (TNF)-α in epithelial cell proliferation, we performed organ culture of mouse eyes with TNF-α, SN50, or an inhibitor of c-Jun N-terminal kinase (JNK) and examined cell proliferation in healing corneal epithelium in TNF-α−/− mice treated with SN50. An acceleration of epithelial cell proliferation by SN50 treatment was found to depend on TNF-α/JNK signaling. In conclusion, topical application of SN50 is effective in treating corneal alkali burns in mice. PMID:15855640

Assessing Possible Improvements in NATO’s Non-Strategic Nuclear Deterrence Forces

DTIC Science & Technology

2017-12-01

QUESTION Currently, the only U.S. nuclear weapon based in Europe is the B-61 gravity bomb . The B-61 could be delivered by U.S. and Allied fighter-bomber...currently consists of only air-delivered B-61 gravity bombs . This thesis therefore addresses a little- studied topic of growing importance. Literature on...Postgraduate School, 1989), 53–4, http://hdl.handle.net/10945/29008. 6 would not be possible when using DCA to deliver a B-61 gravity bomb

50 CFR Table 1b to Part 660... - 2009, Harvest Guidelines for Minor Rockfish by Depth Sub-groups (weights in metric tons)

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false 2009, Harvest Guidelines for Minor Rockfish by Depth Sub-groups (weights in metric tons) 1b Table 1b to Part 660, Subpart G Wildlife and... 660, Subpart G—2009, Harvest Guidelines for Minor Rockfish by Depth Sub-groups (weights in metric tons...

Unmanned Bomber: The Effects It Will Bring to the Nuclear Triad

DTIC Science & Technology

2014-06-01

New York, NY: Avery Trade, 2011), 41. 16 Boeing, History of B-2 Spirit , http://www.boeing.com/boeing/history/boeing/ b2 .page retrieved on January...factsheets/start1 retrieved on February 23, 2014 Boeing, History of B-2 Spirit , http://www.boeing.com/boeing/history/boeing/ b2 .page retrieved on

Making the Sea Safer: A National Agenda for Maritime Security and Counterterrorism

DTIC Science & Technology

2005-02-17

small boats as weapons. On November 7, 2000, for example, a Hamas suicide bomber aboard a fishing boat tried to attack an Israeli patrol craft...could involve the use of suicide bombers, as in the case of the Cole, or vessels on autopilot or with remote triggers. It could occur while the targeted...ship or port in the waters of Western Europe, Japan , or the United States. Besides using conventional explosives, the bombers aboard a small boat could

39 CFR 3030.50 - Remedies.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Remedies. 3030.50 Section 3030.50 Postal Service....50 Remedies. (a) If the Commission finds that a complaint is justified, it will order that the Postal... applicable requirements; and (2) Remedy the effects of any non-compliance. (b) If the Commission finds...

39 CFR 3030.50 - Remedies.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 39 Postal Service 1 2011-07-01 2011-07-01 false Remedies. 3030.50 Section 3030.50 Postal Service....50 Remedies. (a) If the Commission finds that a complaint is justified, it will order that the Postal... applicable requirements; and (2) Remedy the effects of any non-compliance. (b) If the Commission finds...

Air and Space Power Journal. Volume 16, Number 4, Winter 2002

DTIC Science & Technology

2002-01-01

www.wpafb.af.mil/ museum/research/bombers/ b1 -10.htm. The Oath of Office A Historical Guide to Moral Leadership LT COL KENNETH KESKEL, USAF Editorial...typical of the Royal Air Force (RAF) between the wars, excelling at rugby , boxing, and cricket (in which he was scheduled to compete for England

Function library programming to support B89 evaluation of Sheffield Apollo RS50 DCC (Direct Computer Control) CMM (Coordinate Measuring Machine)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Frank, R.N.

1990-02-28

The Inspection Shop at Lawrence Livermore Lab recently purchased a Sheffield Apollo RS50 Direct Computer Control Coordinate Measuring Machine. The performance of the machine was specified to conform to B89 standard which relies heavily upon using the measuring machine in its intended manner to verify its accuracy (rather than parametric tests). Although it would be possible to use the interactive measurement system to perform these tasks, a more thorough and efficient job can be done by creating Function Library programs for certain tasks which integrate Hewlett-Packard Basic 5.0 language and calls to proprietary analysis and machine control routines. This combinationmore » provides efficient use of the measuring machine with a minimum of keyboard input plus an analysis of the data with respect to the B89 Standard rather than a CMM analysis which would require subsequent interpretation. This paper discusses some characteristics of the Sheffield machine control and analysis software and my use of H-P Basic language to create automated measurement programs to support the B89 performance evaluation of the CMM. 1 ref.« less

50 CFR Table 47b to Part 679 - Percent of the AFA Mothership Sector's Pollock Allocation, Numbers of Chinook Salmon Used To...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Percent of the AFA Mothership Sector's Pollock Allocation, Numbers of Chinook Salmon Used To Calculate the Opt-Out Allocation and Annual Threshold Amount, and Percent Used To Calculate IPA Minimum Participation Assigned to Each Mothership Under § 679.21(f) 47b Table 47b to Part 679...

50 CFR Table 47b to Part 679 - Percent of the AFA Mothership Sector's Pollock Allocation, Numbers of Chinook Salmon Used To...

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Percent of the AFA Mothership Sector's Pollock Allocation, Numbers of Chinook Salmon Used To Calculate the Opt-Out Allocation and Annual Threshold Amount, and Percent Used To Calculate IPA Minimum Participation Assigned to Each Mothership Under § 679.21(f) 47b Table 47b to Part 679...

In-situ X-ray diffraction studies of the phase transformations and structural states of B2, R and B19′ phases in Ti{sub 49.5}Ni{sub 50.5} alloy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ostapenko, Marina G., E-mail: artifakt@ispms.tsc.ru; National Research Tomsk Polytechnic University, Tomsk, 634050; Meisner, Ludmila L., E-mail: llm@ispms.tsc.ru

2015-10-27

The martensitic transformation, Debye–Waller factor, mean-square atomic displacements and the coefficient of thermal expansion on cooling of the Ti{sub 49.5}Ni{sub 50.5} shape memory alloy were examined using in-situ X-ray diffraction. It was revealed B2→R (T{sub R} ≡ T = 273 ± 10 K) along with B2→B19’ (M{sub s} ≡ T = 273 ± 10 K) transitions occur. It was found that Debye–Waller factor and mean-square displacement of B2 phase undergo significant increase as functions of temperature when phase transition B2→R and B2→B19’ take place. The analysis of the thermal expansion coefficient of the B2 phase indicates that the value of a increasesmore » almost linearly while cooling.« less

WORLD WAR III The 1960's Version

NASA Astrophysics Data System (ADS)

Brocklebank, Roy

2005-09-01

This article is based on a lecture to the Royal Institute of Navigation History of Air Navigation Group at Tangmere Museum on 12 May 2004. The author served as a navigator-radar or a radar bomb aimer within RAF Bomber Command during the mid-1960s. This article is based on his experience of this time in Bomber Command and describes how the Medium Bomber Force would have carried out their war operations had nuclear deterrence failed. In its day these plans were TOP SECRET.

A > 4 MGy radiation tolerant 8 THzOhm transimpedance amplifier with 50 dB dynamic range

NASA Astrophysics Data System (ADS)

Verbeeck, J.; Steyaert, M.; Leroux, P.

2013-02-01

A 130 nm Transimpedance Amplifier has been developed with a 255 MHz bandwidth, 90 dBΩ transimpedance gain and a dynamic input range of 1:325 or 50 dB for a photo-diode capacitance of 0.75 pF. The equivalent integrated input noise is 160 nA @ 25°C. The gain of the voltage amplifier, used in the transimpedance amplifier (TIA), degrades less than 3% over a temperature range from -40 °C up to 125 °C. The TIA and attenuator exhibit a radiation tolerance larger than 4 MGy, as evidenced by radiation assessment.

50 CFR 300.66 - Prohibitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... accordance with the annual management measures published pursuant to 50 CFR 300.62. (b) Fish for halibut except in accordance with the catch sharing plans and domestic management measures implemented under 50... while commercial fishing or from sport fishing, as defined at § 300.61, except that persons authorized...

50 CFR Table 2b to Part 660... - 2010, and Beyond, Harvest Guidelines for Minor Rockfish by Depth Sub-groups (weights in metric tons)

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false 2010, and Beyond, Harvest Guidelines for Minor Rockfish by Depth Sub-groups (weights in metric tons) 2b Table 2b to Part 660, Subpart G Wildlife... Part 660, Subpart G—2010, and Beyond, Harvest Guidelines for Minor Rockfish by Depth Sub-groups...

A Case Study of Manned Strategic Bomber Acquisition: The B-70 Valkyrie

DTIC Science & Technology

1990-09-01

TIC Aproved for public ,, iota ,: L.c E - DEPARTMENT OF THE AIR FORCE S AIR UNIVERSITYAIR FORCE INSTITUTE OF TECHNOLOGY iTHESI W right- Patterson Air...found that covered the political history in a thorough, chronological manner. Additionally, because of security classification or other sensitivities...discussions. The first step in securing the interview was a formal, written requests from the AFIT/LS Dean, shown in Appendix A. Any further steps in the

14. Photocopy of historic photograph (original photograph on file at ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of historic photograph (original photograph on file at Fairchild Air Force Museum, Spokane, WA) Photographer unknown, date unknown BOMBER ALERT FACILITY, INTERIOR, SLEEPING QUARTERS - Fairchild Air Force Base, Bomber Alert Facility, 803G South Taxi Way, Spokane, Spokane County, WA

Intercontinental Ballistic Missiles and their Role in Future Nuclear Forces

DTIC Science & Technology

2017-05-01

they cannot carry nuclear weapons. The B-52 relies entirely on the ALCM, whereas the B-2 currently relies on unguided bombs . A new stealthy bomber...SLBM program within the next five to seven years to maintain SLBM availability into the 2050s and beyond. bomb . The new bomb will be used by stealthy...accuracy combination in an ICBM, an SLBM, a guided bomb , or a cruise missile. Similarly, speed of response and in-flight survivability favor ICBMs

First principles study of the ground state properties of Si, Ga, and Ge doped Fe50Al50

NASA Astrophysics Data System (ADS)

Pérez, Carlos Ariel Samudio; dos Santos, Antonio Vanderlei

2018-06-01

The first principles calculation of the structural, electronic and associated properties of the Fe50Al50 alloy (B2 phase) doped by s-p elements (Im = Si, Ga, and Ge) are performed as a function of the atomic concentration on the basis of the Full Potential Linear Augmented Plane Wave (FP-LAPW) method as implemented in the WIEN2k code. The Al substitution by Im (Si and Ge) atoms (principally at a concentration of 6.25 at%) induces a pronounced redistribution of the electronic charge leading to a strong Fe-Im interaction with covalent bonding character. At the same time, decrease the lattice volume (V) while increase the bulk modulus (B). For the alloys containing Ga, the Fe-Ga interaction is also observed but the V and B of the alloy are very near to that of pure Fe-Al alloy. The magnetic moment and hyperfine parameters observed at the lattice sites of studied alloys also show variations, they increase or decrease in relation to that in Fe50Al50 according to the Im that substitutes Al.

The Need for Non-Lethal Weapons in Major Combat Operations

DTIC Science & Technology

2008-04-23

and sent out a shock wave similar to a sonic boom that in theory could have downed a B-17 bomber. Its effects 4 were disabling, rather than...malodorants and toxic incapacitating agents) Mechanical technologies (including nets and barriers) Acoustic technologies (such as infra - and...oxide AUDIBLE INFRASONIC ULTRASONIC BARRIERS Caltrops Tire spikes and strips ENTANGLEMENTS Portable vehicle arresting barrier Running

Defense.gov Special Report: Travels With Hagel

Science.gov Websites

institution in ways that we've never had to." Story Hagel Discusses Transitions at Marine Corps Base Base Defense Secretary Chuck Hagel opened his final domestic trip with a stop at Whiteman Air Force Base, home of the 509th Bomb Wing -- the world's only B-2 Spirit stealth bomber unit, where he told

Aircraft Transparency Failure and Logistical Cost Analysis. Volume I. Program Summary

DTIC Science & Technology

1978-12-01

Hours liv LIST OF ABBREVIATIONS (Continued) SFMC Field Maintenance Cost FMEA Failure Modes and Effect Analysis SFMS Field Maintenance Squadron FSN...3, CH-53, AND UH -1 Figure 3. Study Aircraft 10 I. 1. WINDSHIELDS 2. CANOPIES 3. WINDOWS INTERACTIVE SUPPORT SYSTEMS 1. ANTI-ICING 2. DEFOGGING 3...52,947 13,761 UH /TH-1F, 1P 73,431 73,640 Total helicopters 339,690 113,492 2.99 Bombers B-S2G 138,348 64,431 B-S2P 93,000 36,936 B-57 34,527 19,552

22 CFR 50.20 - Retention of nationality.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Retention of nationality. 50.20 Section 50.20 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS NATIONALITY PROCEDURES Retention and Resumption of Nationality § 50.20 Retention of nationality. (a) Section 351(b) of the Immigration and...

22 CFR 50.20 - Retention of nationality.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Retention of nationality. 50.20 Section 50.20 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS NATIONALITY PROCEDURES Retention and Resumption of Nationality § 50.20 Retention of nationality. (a) Section 351(b) of the Immigration and...

22 CFR 50.20 - Retention of nationality.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Retention of nationality. 50.20 Section 50.20 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS NATIONALITY PROCEDURES Retention and Resumption of Nationality § 50.20 Retention of nationality. (a) Section 351(b) of the Immigration and...

22 CFR 50.20 - Retention of nationality.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Retention of nationality. 50.20 Section 50.20 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS NATIONALITY PROCEDURES Retention and Resumption of Nationality § 50.20 Retention of nationality. (a) Section 351(b) of the Immigration and...

22 CFR 50.20 - Retention of nationality.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Retention of nationality. 50.20 Section 50.20 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS NATIONALITY PROCEDURES Retention and Resumption of Nationality § 50.20 Retention of nationality. (a) Section 351(b) of the Immigration and...

Effect of Boron Addition on Microstructural Evolution and Room-Temperature Mechanical Properties of Novel Fe66- x CrNiB x Si ( x = 0, 0.25, 0.50 and 0.75 Wt Pct) Advanced High-Strength Steels

NASA Astrophysics Data System (ADS)

Askari-Paykani, Mohsen; Shahverdi, Hamid Reza; Miresmaeili, Reza

2016-11-01

In this study, the Vickers hardnesses and room-temperature uniaxial tensile behaviors of four Fe66- x CrNiB x Si ( x = 0 (0B), 0.25 (25B), 0.50 (50B), and 0.75 (75B) wt pct) advanced high-strength steels (AHSSs) in the as-hot-rolled and heat-treated (1373 K (1100 °C)/2 h + 973 K (700 °C)/20 min) conditions were investigated. Microstructural evolution after solidification, hot rolling, heat treatment, and uniaxial tensile tests of 0B, 25B, 50B, and 75B AHSSs was also characterized using field emission gun scanning electron microscopy and X-ray diffraction. The tensile behaviors of the 0B, 25B, 50B, and 75B AHSSs were manifested by an excellent combination of strength and ductility over 34.7 and 47.1 GPa pct, 36.9 and 42.3 GPa pct, 45.9 and 46.4 GPa pct, and 11.9 and 47.8 GPa pct, respectively, arising from microband-induced plasticity in the 0B, 50B, and 75B AHSSs and transformation-induced plasticity in the 25B specimens. All specimens in the as-hot-rolled and heat-treated states showed an austenitic matrix grain. Adding boron to the base alloy (0B) resulted in grain refinement, M2B dispersion, precipitation hardening, and solid solution strengthening, which led to an increase in strength. The results of the present work show promise for automotive applications that require excellent properties and reduced specific weight.

U.S. Strategic Nuclear Forces: Background, Developments, and Issues

DTIC Science & Technology

2015-03-18

5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Congressional Research Service,The...extend the life of the missiles and warheads so that they and the submarines can remain in the fleet past 2020. It is designing a new submarine and...modifying and extending the life of the B61 bomb carried on B-2 bombers and fighter aircraft. The Obama Administration completed a review of the size and

1. COMPARISON OF PLANS, SHOWING KONGENSGADE 6 (see photograph VI50 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. COMPARISON OF PLANS, SHOWING KONGENSGADE 6 (see photograph VI-50 50-2 for elevation), KONGENSGADE 8 (see photograph VI-50-3 for elevation), KONGENSGADE 9 (see photograph VI-50-3 for elevation), KONGENSGADE 17 (see photograph VI-50-5 for elevation), KONGENSGADE 56 (see photograph VI-50-8 for elevation), & KONGENSGADE 57 (see photograph VI-50-9 for elevation) - King Street Area Study, Kongensgade 5-18, 36, 37B, 51-58 (Houses), 5-18, 36-37B, 51-58 King Street, Frederiksted, St. Croix, VI

43 CFR 3927.50 - Diligent development.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Diligent development. 3927.50 Section 3927.50 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT... development. Oil shale lessees must meet: (a) Diligent development milestones; (b) Annual minimum production...

20 CFR 655.50 - Enforcement process.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Enforcement process. 655.50 Section 655.50... FOREIGN WORKERS IN THE UNITED STATES Labor Certification Process and Enforcement of Attestations for Temporary Employment in Occupations Other Than Agriculture or Registered Nursing in the United States (H-2B...

Classification and Progression Based on CFS-GA and C5.0 Boost Decision Tree of TCM Zheng in Chronic Hepatitis B.

PubMed

Chen, Xiao Yu; Ma, Li Zhuang; Chu, Na; Zhou, Min; Hu, Yiyang

2013-01-01

Chronic hepatitis B (CHB) is a serious public health problem, and Traditional Chinese Medicine (TCM) plays an important role in the control and treatment for CHB. In the treatment of TCM, zheng discrimination is the most important step. In this paper, an approach based on CFS-GA (Correlation based Feature Selection and Genetic Algorithm) and C5.0 boost decision tree is used for zheng classification and progression in the TCM treatment of CHB. The CFS-GA performs better than the typical method of CFS. By CFS-GA, the acquired attribute subset is classified by C5.0 boost decision tree for TCM zheng classification of CHB, and C5.0 decision tree outperforms two typical decision trees of NBTree and REPTree on CFS-GA, CFS, and nonselection in comparison. Based on the critical indicators from C5.0 decision tree, important lab indicators in zheng progression are obtained by the method of stepwise discriminant analysis for expressing TCM zhengs in CHB, and alterations of the important indicators are also analyzed in zheng progression. In conclusion, all the three decision trees perform better on CFS-GA than on CFS and nonselection, and C5.0 decision tree outperforms the two typical decision trees both on attribute selection and nonselection.

The Port Moresby-Solomons Operation and the Allied Reaction, 27 Apr - 11 May 1942

DTIC Science & Technology

2012-01-01

started their attack, giving most of their attention to Lexington. Yorktown received one bomb hit, but Lexington was struck by two tor- pedoes and two...bombers, and thirty tor- pedo bombers) and 1,074 men; the Allies lost sixty-six aircraft and 543 men.235 One Japanese large carrier was heavily damaged

Expression of Arg-Gingipain RgpB is required for correct glycosylation and stability of monomeric Arg-gingipain RgpA from Porphyromonas gingivalis W50.

PubMed

Rangarajan, Minnie; Hashim, Ahmed; Aduse-Opoku, Joseph; Paramonov, Nikolay; Hounsell, Elizabeth F; Curtis, Michael A

2005-08-01

Arg-gingipains are extracellular cysteine proteases produced by the gram-negative periodontal pathogen Porphyromonas gingivalis and are encoded by rgpA and rgpB. Three Arg-gingipains, heterodimeric high-molecular-mass Arg-gingipain HRgpA comprising the alpha-catalytic chain and the beta-adhesin chain, the monomeric soluble Arg-gingipain comprising only the alpha-catalytic chain (RgpA(cat)), and the monomeric membrane-type heavily glycosylated Arg-gingipain comprising the alpha-catalytic chain (mt-RgPA(cat)), are derived from rgpA. The monomeric enzymes contain between 14 and 30% carbohydrate by weight. rgpB encodes two monomeric enzymes, RgpB and mt-RgpB. Earlier work indicated that rgpB is involved in the glycosylation process, since inactivation of rgpB results in the loss of not only RgpB and mt-RgpB but also mt-RgpA(cat). This work aims to confirm the role of RgpB in the posttranslational modification of RgpA(cat) and the effect of aberrant glycosylation on the properties of this enzyme. Two-dimensional gel electrophoresis of cellular proteins from W50 and an inactivated rgpB strain (D7) showed few differences, suggesting that loss of RgpB has a specific effect on RgpA maturation. Inactivation of genes immediately upstream and downstream of rgpB had no effect on rgpA-derived enzymes, suggesting that the phenotype of the rgpB mutant is not due to a polar effect on transcription at this locus. Matrix-assisted laser desorption ionization-time of flight analysis of purified RgpA(cat) from W50 and D7 strains gave identical peptide mass fingerprints, suggesting that they have identical polypeptide chains. However, RgpA(cat) from D7 strain had a higher isoelectric point and a dramatic decrease in thermostability and did not cross-react with a monoclonal antibody which recognizes a glycan epitope on the parent strain enzyme. Although it had the same total sugar content as the parent strain enzyme, there were significant differences in the monosaccharide composition and

Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors.

PubMed

Li, Yingjun; Yu, Yang; Jin, Kun; Gao, Lixin; Luo, Tongchuan; Sheng, Li; Shao, Xin; Li, Jia

2014-09-01

A series of novel thiadiazole amide derivatives have been synthesized and evaluated for inhibitory activities against Cdc25B and PTP1B. Most of them showed inhibitory activities against Cdc25B (IC50=1.18-8.01 μg/mL) and PTP1B (IC50=0.85-8.75 μg/mL), respectively. Moreover, compounds 5b and 4l were most potent with IC50 values of 1.18 and 0.85 μg/mL for Cdc25B and PTP1B, respectively, compared with reference drugs Na3VO4 (IC50=0.93 μg/mL) and oleanolic acid (IC50=0.85 μg/mL). The results of selectivity experiments showed that the target compounds were selective inhibitors against PTP1B and Cdc25B. Enzyme kinetic experiments demonstrated that compound 5k was a specific inhibitor with the typical characteristics of a mixed inhibitor. Copyright © 2014 Elsevier Ltd. All rights reserved.

Determination of dissociation constant of the NFκB p50/p65 heterodimer using fluorescence cross-correlation spectroscopy in the living cell

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tiwari, Manisha; Mikuni, Shintaro; Muto, Hideki

Highlights: •We used two-laser-beam FCCS to determine the dissociation constant (K{sub d}) of IPT domain of p50/p65 heterodimer in living cell. •Interaction of p50 and p65 was analyzed in the cytoplasm and nucleus of single living cell. •Binding affinity of p50/p65 heterodimer is higher in cytoplasm than that of nucleus. -- Abstract: Two-laser-beam fluorescence cross-correlation spectroscopy (FCCS) is promising technique that provides quantitative information about the interactions of biomolecules. The p50/p65 heterodimer is the most abundant and well understood of the NFκB dimers in most cells. However, the quantitative value of affinity, namely the K{sub d}, for the heterodimer inmore » living cells is not known yet. To quantify the heterodimerization of the IPT domain of p50/p65 in the living cell, we used two-laser-beam FCCS. The K{sub d} values of mCherry{sub 2}- and EGFP-fused p50 and p65 were determined to be 0.46 μM in the cytoplasm and 1.06 μM in the nucleus of the living cell. These results suggest the different binding affinities of the p50/p65 heterodimer in the cytoplasm and nucleus of the living cell and different complex formation in each region.« less

41 CFR 50-204.32 - Records.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Records. 50-204.32... Radiation Standards § 50-204.32 Records. (a) Every employer shall maintain records of the radiation exposure... employees of his individual exposure on at least an annual basis. (b) Every employer shall maintain records...

41 CFR 50-204.32 - Records.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Records. 50-204.32... Radiation Standards § 50-204.32 Records. (a) Every employer shall maintain records of the radiation exposure... employees of his individual exposure on at least an annual basis. (b) Every employer shall maintain records...

41 CFR 50-204.32 - Records.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Records. 50-204.32... Radiation Standards § 50-204.32 Records. (a) Every employer shall maintain records of the radiation exposure... employees of his individual exposure on at least an annual basis. (b) Every employer shall maintain records...

41 CFR 50-204.32 - Records.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Records. 50-204.32... Radiation Standards § 50-204.32 Records. (a) Every employer shall maintain records of the radiation exposure... employees of his individual exposure on at least an annual basis. (b) Every employer shall maintain records...

41 CFR 50-203.17 - Hearings.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Hearings. 50-203.17...-Healey Public Contracts Act § 50-203.17 Hearings. (a) Hearings held for the purpose of receiving evidence... administrative law judge. (b) Due notice of hearing shall be published in the Federal Register. (c) The hearing...

41 CFR 50-203.17 - Hearings.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Hearings. 50-203.17...-Healey Public Contracts Act § 50-203.17 Hearings. (a) Hearings held for the purpose of receiving evidence... administrative law judge. (b) Due notice of hearing shall be published in the Federal Register. (c) The hearing...

41 CFR 50-203.17 - Hearings.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Hearings. 50-203.17...-Healey Public Contracts Act § 50-203.17 Hearings. (a) Hearings held for the purpose of receiving evidence... administrative law judge. (b) Due notice of hearing shall be published in the Federal Register. (c) The hearing...

50 Years of renal physiology from one man and the perfused tubule: Maurice B. Burg.

PubMed

Hamilton, Kirk L; Moore, Antoni B

2016-08-01

Technical advancements in research techniques in science are made in slow increments. Even so, large advances from insight and hard work of an individual with a single technique can have astonishing ramifications. Here, we examine the impact of Dr. Maurice B. Burg and the isolated perfused renal tubule technique and celebrate the 50th anniversary of the publication by Dr. Burg and his colleagues of their landmark paper in the American Journal of Physiology in 1966. In this study, we have taken a scientific visualization approach to study the scientific contributions of Dr. Burg and the isolated perfused tubule preparation as determining research impact by the number of research students, postdoctoral fellows, visiting scientists, and national and international collaborators. Additionally, we have examined the research collaborations (first and second generation scientists), established the migrational visualization of the first generation scientists who worked directly with Dr. Burg, quantified the metrics indices, identified and quantified the network of coauthorship of the first generation scientists with their second generation links, and determined the citations analyses of outputs of Dr. Burg and/or his first generation collaborators as coauthors. We also review the major advances in kidney physiology that have been made with the isolated perfused tubule technique. Finally, we are all waiting for the discoveries that the isolated perfused preparation technique will bring during the next 50 years. Copyright © 2016 the American Physiological Society.

X-2 on Transportation Dolly

NASA Technical Reports Server (NTRS)

1952-01-01

This 1952 photograph shows the X-2 #2 aircraft mounted on a special transportation dolly at Edwards Air Force Base, California. The dolly was steerable and was used for transporting the X-2 around and for towing it off the lakebed at Edwards Air Force Base after a landing. This was the number 2 airplane (46-675), which was lost on May 12, 1953, on a captive flight over Lake Ontario when the airplane exploded during a liquid-oxygen topoff test, killing the pilot, Jean Ziegler, and EB-50A crewman Frank Wolko. Almost no debris was recovered from Lake Ontario, so no cause for the explosion could be determined. Later, however, investigations of similar explosions in the X-1 #3, X-1A, and X-1D traced the problem to Ulmer leather gaskets, which exuded tricresyl phosphate. This substance caused detonations in the supercold atmosphere of the airplanes' liquid oxygen tanks. As the X-2 #2 also had these gaskets, they were probably the cause of the explosion in that aircraft as well. The X-2 was a swept-wing, rocket-powered aircraft designed to fly faster than Mach 3 (three times the speed of sound). It was built for the U.S. Air Force by the Bell Aircraft Company, Buffalo, New York. The X-2 was flown to investigate the problems of aerodynamic heating as well as stability and control effectiveness at high altitudes and high speeds (in excess of Mach 3). Bell aircraft built two X-2 aircraft. These were constructed of K-monel (a copper and nickel alloy) for the fuselage and stainless steel for the swept wings and control surfaces. The aircraft had ejectable nose capsules instead of ejection seats because the development of ejection seats had not reached maturity at the time the X-2 was conceived. The X-2 ejection canopy was successfully tested using a German V-2 rocket. The X-2 used a skid-type landing gear to make room for more fuel. The airplane was air launched from a modified Boeing B-50 Superfortress Bomber. X-2 Number 1 made its first unpowered glide flight on Aug. 5, 1954

The Pros and Cons of National Defense: A Study of the Proponents, Opponents, Issues, and the Public Affairs and Public Relations Programs Surrounding the B-1 Strategic Bomber

DTIC Science & Technology

1979-08-01

it was noted that I the B-I would be faster, carry more payload, and have a smaller radar cross section than the B-52. Also, in comparison to the B-52...payload or have smaller cross section . (6) Compared to B-52, B-i will: (a) Have higher penetration speeds (b) Have larger payload capacity (c) Have... radar detection range, then S I descend to below radar detection altitudes (literally at treetop levels) and penetrate enemy airspace to within

The Long Good-Bye: Why B. F. Skinner's "Verbal Behavior" Is Alive and Well on the 50th Anniversary of Its Publication

ERIC Educational Resources Information Center

Schlinger, Henry D.

2008-01-01

The year 2007 marked the 50th anniversary of the publication of B. F. Skinner's "Verbal Behavior", a book that by Skinner's own account was his most important. The received view, however, is that a devastating review by a young linguist not only rendered Skinner's interpretation of language moot but was also a major factor in ending the hegemony…

Marine Biotoxins: Laboratory Culture and Molecular Structure

DTIC Science & Technology

1989-10-18

associated with the human fish intoxication known as ciguatera , ciguatoxin and umitotoxin. and with palytoxin. Each of the three toxins presents a different...B. Current Status 1. Ciguatoxin The PI reviewed the status of ciguatera research at the Mycotoxins and Phycotoxins Symposium "n August, 1988 in...CITED BOMBER. J.W.. RUBIO. G.G. and NORRIS. D.R. (1989) Epiphytism of dinoflagellates associated with the disease ciguatera : substrate specificity and

Thermoelastic martensitic transformations in ternary Ni50Mn50- z Ga z alloys

NASA Astrophysics Data System (ADS)

Belosludtseva, E. S.; Kuranova, N. N.; Marchenkova, E. B.; Popov, A. G.; Pushin, V. G.

2016-01-01

We have studied the effect of gallium alloying on the structure, phase composition, and physical properties of ternary alloys of the Ni50Mn50- z Ga z (0 ≤ z ≤ 25 at %) quasi-binary section in a broad temperature range. Dependences of the type of crystalline structure of the high-temperature austenite phase and martensite, as well as the critical temperatures of martensitic transformations on the alloy composition, are determined. A phase diagram of the structural and magnetic transformations is constructed. Concentration boundaries of the existence of tetragonal L10 (2 M) martensite and martensitic phases (10 M and 14 M) with complex multilayer crystalline lattices are found. It is established that the predominant martensite morphology is determined by the hierarchy of packets of thin coherent nano- and submicrocrystalline plates with habit planes close to {011} B2, pairwise twinned along one of 24 equivalent {011}<011> B2 twinning shear systems.

Genetic evidence for the involvement of the S-layer protein gene sap and the sporulation genes spo0A, spo0B, and spo0F in Phage AP50c infection of Bacillus anthracis.

PubMed

Plaut, Roger D; Beaber, John W; Zemansky, Jason; Kaur, Ajinder P; George, Matroner; Biswas, Biswajit; Henry, Matthew; Bishop-Lilly, Kimberly A; Mokashi, Vishwesh; Hannah, Ryan M; Pope, Robert K; Read, Timothy D; Stibitz, Scott; Calendar, Richard; Sozhamannan, Shanmuga

2014-03-01

In order to better characterize the Bacillus anthracis typing phage AP50c, we designed a genetic screen to identify its bacterial receptor. Insertions of the transposon mariner or targeted deletions of the structural gene for the S-layer protein Sap and the sporulation genes spo0A, spo0B, and spo0F in B. anthracis Sterne resulted in phage resistance with concomitant defects in phage adsorption and infectivity. Electron microscopy of bacteria incubated with AP50c revealed phage particles associated with the surface of bacilli of the Sterne strain but not with the surfaces of Δsap, Δspo0A, Δspo0B, or Δspo0F mutants. The amount of Sap in the S layer of each of the spo0 mutant strains was substantially reduced compared to that of the parent strain, and incubation of AP50c with purified recombinant Sap led to a substantial reduction in phage activity. Phylogenetic analysis based on whole-genome sequences of B. cereus sensu lato strains revealed several closely related B. cereus and B. thuringiensis strains that carry sap genes with very high similarities to the sap gene of B. anthracis. Complementation of the Δsap mutant in trans with the wild-type B. anthracis sap or the sap gene from either of two different B. cereus strains that are sensitive to AP50c infection restored phage sensitivity, and electron microscopy confirmed attachment of phage particles to the surface of each of the complemented strains. Based on these data, we postulate that Sap is involved in AP50c infectivity, most likely acting as the phage receptor, and that the spo0 genes may regulate synthesis of Sap and/or formation of the S layer.

Genetic Evidence for the Involvement of the S-Layer Protein Gene sap and the Sporulation Genes spo0A, spo0B, and spo0F in Phage AP50c Infection of Bacillus anthracis

PubMed Central

Beaber, John W.; Zemansky, Jason; Kaur, Ajinder P.; George, Matroner; Biswas, Biswajit; Henry, Matthew; Bishop-Lilly, Kimberly A.; Mokashi, Vishwesh; Hannah, Ryan M.; Pope, Robert K.; Read, Timothy D.; Stibitz, Scott; Calendar, Richard; Sozhamannan, Shanmuga

2014-01-01

In order to better characterize the Bacillus anthracis typing phage AP50c, we designed a genetic screen to identify its bacterial receptor. Insertions of the transposon mariner or targeted deletions of the structural gene for the S-layer protein Sap and the sporulation genes spo0A, spo0B, and spo0F in B. anthracis Sterne resulted in phage resistance with concomitant defects in phage adsorption and infectivity. Electron microscopy of bacteria incubated with AP50c revealed phage particles associated with the surface of bacilli of the Sterne strain but not with the surfaces of Δsap, Δspo0A, Δspo0B, or Δspo0F mutants. The amount of Sap in the S layer of each of the spo0 mutant strains was substantially reduced compared to that of the parent strain, and incubation of AP50c with purified recombinant Sap led to a substantial reduction in phage activity. Phylogenetic analysis based on whole-genome sequences of B. cereus sensu lato strains revealed several closely related B. cereus and B. thuringiensis strains that carry sap genes with very high similarities to the sap gene of B. anthracis. Complementation of the Δsap mutant in trans with the wild-type B. anthracis sap or the sap gene from either of two different B. cereus strains that are sensitive to AP50c infection restored phage sensitivity, and electron microscopy confirmed attachment of phage particles to the surface of each of the complemented strains. Based on these data, we postulate that Sap is involved in AP50c infectivity, most likely acting as the phage receptor, and that the spo0 genes may regulate synthesis of Sap and/or formation of the S layer. PMID:24363347

Average current per vacuum-arc cathode spot and spot velocity in a magnetic field on a CuCr50/50 nanocomposite

NASA Astrophysics Data System (ADS)

Zabello, K. K.; Poluyanova, I. N.; Yakovlev, V. V.; Shkol'nik, S. M.

2017-11-01

It has been shown that such cathode spot characteristics as the average current per spot and its dependence on tangential magnetic-field induction B t and the spot velocity and its dependence on B t for two CuCr50/50 specimens with very different structures (nanocomposite and "solid-state sintered" composite) almost coincide if the surface of contacts has been totally remelted before measurements with the use of moderate arc currents in the process of conditioning.

46 CFR 97.37-50 - Ventilation alarm failure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Ventilation alarm failure. 97.37-50 Section 97.37-50... OPERATIONS Markings for Fire and Emergency Equipment, Etc. § 97.37-50 Ventilation alarm failure. (a) The...-inch letters “VENTILATION FAILURE IN VEHICULAR SPACE.” (b) [Reserved] [CGFR 66-33, 31 FR 15286, Dec. 6...

46 CFR 97.37-50 - Ventilation alarm failure.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 46 Shipping 4 2012-10-01 2012-10-01 false Ventilation alarm failure. 97.37-50 Section 97.37-50... OPERATIONS Markings for Fire and Emergency Equipment, Etc. § 97.37-50 Ventilation alarm failure. (a) The...-inch letters “VENTILATION FAILURE IN VEHICULAR SPACE.” (b) [Reserved] [CGFR 66-33, 31 FR 15286, Dec. 6...

46 CFR 97.37-50 - Ventilation alarm failure.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Ventilation alarm failure. 97.37-50 Section 97.37-50... OPERATIONS Markings for Fire and Emergency Equipment, Etc. § 97.37-50 Ventilation alarm failure. (a) The...-inch letters “VENTILATION FAILURE IN VEHICULAR SPACE.” (b) [Reserved] [CGFR 66-33, 31 FR 15286, Dec. 6...

46 CFR 97.37-50 - Ventilation alarm failure.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Ventilation alarm failure. 97.37-50 Section 97.37-50... OPERATIONS Markings for Fire and Emergency Equipment, Etc. § 97.37-50 Ventilation alarm failure. (a) The...-inch letters “VENTILATION FAILURE IN VEHICULAR SPACE.” (b) [Reserved] [CGFR 66-33, 31 FR 15286, Dec. 6...

HAT-P-50b, HAT-P-51b, HAT-P-52b, and HAT-P-53b: Three Transiting Hot Jupiters and a Transiting Hot Saturn From the HATNet Survey

NASA Astrophysics Data System (ADS)

Hartman, J. D.; Bhatti, W.; Bakos, G. Á.; Bieryla, A.; Kovács, G.; Latham, D. W.; Csubry, Z.; de Val-Borro, M.; Penev, K.; Buchhave, L. A.; Torres, G.; Howard, A. W.; Marcy, G. W.; Johnson, J. A.; Isaacson, H.; Sato, B.; Boisse, I.; Falco, E.; Everett, M. E.; Szklenar, T.; Fulton, B. J.; Shporer, A.; Kovács, T.; Hansen, T.; Béky, B.; Noyes, R. W.; Lázár, J.; Papp, I.; Sári, P.

2015-12-01

We report the discovery and characterization of four transiting exoplanets by the HATNet survey. The planet HAT-P-50b has a mass of 1.35 {M}{{J}} and radius of 1.29 {R}{{J}}, and orbits a bright (V=11.8 mag) M=1.27 {M}⊙ , R=1.70 {R}⊙ star every P=3.1220 days. The planet HAT-P-51b has a mass of 0.31 {M}{{J}} and radius of 1.29 {R}{{J}}, and orbits a V=13.4 mag, M=0.98 {M}⊙ , R=1.04 {R}⊙ star with a period of P=4.2180 days. The planet HAT-P-52b has a mass of 0.82 {M}{{J}} and radius of 1.01 {R}{{J}}, and orbits a V=14.1 mag, M=0.89 {M}⊙ , R=0.89 {R}⊙ star with a period of P=2.7536 days. The planet HAT-P-53b has a mass of 1.48 {M}{{J}} and radius of 1.32 {R}{{J}}, and orbits a V=13.7 mag, M=1.09 {M}⊙ , R=1.21 {R}⊙ star with a period of P=1.9616 days. All four planets are consistent with having circular orbits and have masses and radii measured to better than 10% precision. The low stellar jitter and favorable {R}p/{R}\\star ratio for HAT-P-51 make it a promising target for measuring the Rossiter-McLaughlin effect for a Saturn-mass planet. Based on observations obtained with the Hungarian-made Automated Telescope Network. Based on observations obtained at the W. M. Keck Observatory, which is operated by the University of California and the California Institute of Technology. Keck time has been granted by NOAO (A245Hr) and NASA (N154Hr, N130Hr). Based on data collected at Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. Based on observations made with the Nordic Optical Telescope, operated on the island of La Palma jointly by Denmark, Finland, Iceland, Norway, Sweden, in the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias. Based on observations obtained with the Tillinghast Reflector 1.5 m telescope and the 1.2 m telescope, both operated by the Smithsonian Astrophysical Observatory at the Fred Lawrence Whipple Observatory in AZ. Based on radial velocities obtained with the

7 CFR 301.50-2 - Regulated articles.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 5 2014-01-01 2014-01-01 false Regulated articles. 301.50-2 Section 301.50-2... articles. The following are regulated articles: (a) Pine products (Pinus spp.), as follows: Bark products... pine wreaths and garlands; and stumps. (b) Any article, product, or means of conveyance not covered by...

7 CFR 301.50-2 - Regulated articles.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Regulated articles. 301.50-2 Section 301.50-2... articles. The following are regulated articles: (a) Pine products (Pinus spp.), as follows: Bark products... pine wreaths and garlands; and stumps. (b) Any article, product, or means of conveyance not covered by...

7 CFR 301.50-2 - Regulated articles.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 5 2011-01-01 2011-01-01 false Regulated articles. 301.50-2 Section 301.50-2... articles. The following are regulated articles: (a) Pine products (Pinus spp.), as follows: Bark products... pine wreaths and garlands; and stumps. (b) Any article, product, or means of conveyance not covered by...

7 CFR 301.50-2 - Regulated articles.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 5 2012-01-01 2012-01-01 false Regulated articles. 301.50-2 Section 301.50-2... articles. The following are regulated articles: (a) Pine products (Pinus spp.), as follows: Bark products... pine wreaths and garlands; and stumps. (b) Any article, product, or means of conveyance not covered by...

7 CFR 301.50-2 - Regulated articles.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 5 2013-01-01 2013-01-01 false Regulated articles. 301.50-2 Section 301.50-2... articles. The following are regulated articles: (a) Pine products (Pinus spp.), as follows: Bark products... pine wreaths and garlands; and stumps. (b) Any article, product, or means of conveyance not covered by...

The New START Treaty: Central Limits and Key Provisions

DTIC Science & Technology

2010-06-18

the parties maintained during the life of the treaty. The parties...and that number can change during the life of the treaty. The parties will not, however, visit each missile to count and calculate the total number... the life of the treaty, but no more than two inspections of any one of the SSGNs. Heavy Bombers Under START, heavy bombers were eliminated

Pursuit of the Torch: Influences on Acquisition of USAAF Fighter Aircraft Used in the North African Campaign

DTIC Science & Technology

2010-06-01

138- 143 . 36 advancing bomber versus pursuit technology took on greater significance. The need to establish a balanced force was just one more...54 Watson, 138- 143 . 55 AAF Statistical Digest: World War II, December 1945, Table 79. The percentage...72 William Wolf American Fighter-Bombers in World War II: USAAF Jabos in the MTO and ETO (Atglen, PA: Schiffer

2007 National Small Business Conference: Critical Infrastructure Opportunities

DTIC Science & Technology

2007-05-18

Flooding of Subway Tunnels From IED Bomber Maximize lives saved – provide time to evacuate Recent advances in inflatable structure technology: • Stronger...Polimetry/ Signal Processing technologies (Radar & Sonar) Low Cost Advanced Composite Structures Low Cost Composite Sandwich Structures and...Ubiquitous Chem/Bio Detect 34 High Impact Technology Solutions Resilient Tunnel Prevent Flooding of Subway Tunnels From IED Bomber Maximize lives saved

48 CFR 9904.413-50 - Techniques for application.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST....412-40(b)(2) and 9904.412-50(b)(4), shall be used to determine the present value of such receivable...

48 CFR 9904.413-50 - Techniques for application.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST....412-40(b)(2) and 9904.412-50(b)(4), shall be used to determine the present value of such receivable...

48 CFR 9904.413-50 - Techniques for application.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., OFFICE OF FEDERAL PROCUREMENT POLICY, OFFICE OF MANAGEMENT AND BUDGET PROCUREMENT PRACTICES AND COST....412-40(b)(2) and 9904.412-50(b)(4), shall be used to determine the present value of such receivable...

Cross section asymmetry of two-body carbon disintegration 12C (γ , p)11B with polarized photons at energy 40-50 MeV

NASA Astrophysics Data System (ADS)

Burdeinyi, D.; Brudvik, J.; Fissum, K.; Ganenko, V.; Hansen, K.; Isaksson, L.; Livingston, K.; Lundin, M.; Nilsson, B.; Schroder, B.

2017-01-01

The cross section asymmetry of 12C (γ ,p01)11B and 12C (γ ,p2-6)11B reactions has been studied at the energy range 40-55 MeV, using linearly polarized tagged photons of the MAX-lab facility. The asymmetry of the 12C (γ ,p01)11B processes, which assume the one-body mechanism of the reaction, is Σ ≈ 0.82 ± 0.05 for photon energies 45-50 MeV. The asymmetry for the 12C (γ ,p2-6)11B reactions, which produce a maximum at excitation energy ∼ 6 MeV, is Σ ≈ 0.53 ± 0.13 for a photon energy 49 MeV. It is close to the asymmetry of reaction of the free deuteron photodisintegration, and can be resulted from the two-body mechanism of the photon absorption.

Flight Tests of Various Tail Modifications on the Brewster XSBA-1 Airplane II : Measurements of Flying Qualities with Tail Configuration Number Two

NASA Technical Reports Server (NTRS)

Phillips, W.H.; Crane, H.L.

1943-01-01

Several tail modifications of the Brewster XSBA-1 scout-bomber were investigated and results compared. Modifications consisted of variation of the chord of the elevator and rudder while the total area of the surfaces is kept constant and variations of the total area of the vertical tail surface. Configuration number 2 reduced trim changes by 50 percent and reduced average elevator control force gradient from 30 to 27 pounds/g. Stick travel required to stall in maneuver was 4.6 inches.

43 CFR 3927.50 - Diligent development.

Code of Federal Regulations, 2014 CFR

2014-10-01

..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL SHALE LEASING Lease Terms § 3927.50 Diligent development. Oil shale lessees must meet: (a) Diligent development milestones; (b) Annual minimum production...

43 CFR 3927.50 - Diligent development.

Code of Federal Regulations, 2012 CFR

2012-10-01

..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL SHALE LEASING Lease Terms § 3927.50 Diligent development. Oil shale lessees must meet: (a) Diligent development milestones; (b) Annual minimum production...

43 CFR 3927.50 - Diligent development.

Code of Federal Regulations, 2013 CFR

2013-10-01

..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) OIL SHALE LEASING Lease Terms § 3927.50 Diligent development. Oil shale lessees must meet: (a) Diligent development milestones; (b) Annual minimum production...

Effect of Temperature on the Deformation Behavior of B2 Austenite in a Polycrystalline Ni49.9Ti50.1 (at.Percent) Shape Memory Alloy

NASA Technical Reports Server (NTRS)

Garg, A.; Benafan, O.; Noebe, R. D.; Padula, S. A., II; Clausen, B.; Vogel, S.; Vaidyanathan, R.

2013-01-01

Superelasticity in austenitic B2-NiTi is of great technical interest and has been studied in the past by several researchers [1]. However, investigation of temperature dependent deformation in B2-NiTi is equally important since competing mechanisms of stress-induced martensite (SIM), retained martensite, plastic and deformation twinning can lead to unusual mechanical behaviors. Identification of the role of various mechanisms contributing to the overall deformation response of B2-NiTi is imperative to understanding and maturing SMA-enabled technologies. Thus, the objective of this work was to study the deformation of polycrystalline Ni49.9Ti50.1 (at. %) above A(sub f) (105 C) in the B2 state at temperatures between 165-440 C, and generate a B2 deformation map showing active deformation mechanisms in different temperature-stress regimes.

46 CFR 95.16-50 - Instructions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... EQUIPMENT Fixed Clean Agent Gas Extinguishing Systems, Details § 95.16-50 Instructions. (a) Simple, complete... agent cylinder storage room. (b) On a system in which extinguishing agent cylinders are stored outside...

46 CFR 95.16-50 - Instructions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... EQUIPMENT Fixed Clean Agent Gas Extinguishing Systems, Details § 95.16-50 Instructions. (a) Simple, complete... agent cylinder storage room. (b) On a system in which extinguishing agent cylinders are stored outside...

46 CFR 95.16-50 - Instructions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... EQUIPMENT Fixed Clean Agent Gas Extinguishing Systems, Details § 95.16-50 Instructions. (a) Simple, complete... agent cylinder storage room. (b) On a system in which extinguishing agent cylinders are stored outside...

46 CFR 32.56-50 - Combustible veneers-T/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Combustible veneers-T/ALL. 32.56-50 Section 32.56-50 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-50 Combustible veneers—T/ALL. (a) Except as provided in paragraph (b) of this section combustible...

46 CFR 32.56-50 - Combustible veneers-T/ALL.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 1 2011-10-01 2011-10-01 false Combustible veneers-T/ALL. 32.56-50 Section 32.56-50 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS SPECIAL EQUIPMENT, MACHINERY, AND HULL....56-50 Combustible veneers—T/ALL. (a) Except as provided in paragraph (b) of this section combustible...

41 CFR 128-50.103 - Investigation of any discrepancy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Management Regulations System (Continued) DEPARTMENT OF JUSTICE 50-SEIZED PERSONAL PROPERTY 50.1-Storage and... property, a board of survey shall conduct an investigation in accordance with 41 CFR 128-51.1. (b) If the...

41 CFR 128-50.103 - Investigation of any discrepancy.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Management Regulations System (Continued) DEPARTMENT OF JUSTICE 50-SEIZED PERSONAL PROPERTY 50.1-Storage and... property, a board of survey shall conduct an investigation in accordance with 41 CFR 128-51.1. (b) If the...

45 CFR 96.50 - Complaints.

Code of Federal Regulations, 2010 CFR

2010-10-01

... health services block grant, the Administrator, Alcohol, Drug Abuse, and Mental Health Administration... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION BLOCK GRANTS Enforcement § 96.50 Complaints... as required by this section. (b) Complaints with respect to the health block grants must be submitted...

41 CFR 60-50.1 - Purpose and scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 50-GUIDELINES ON DISCRIMINATION BECAUSE OF RELIGION OR NATIONAL ORIGIN § 60-50.1 Purpose and scope... performing under federally assisted construction contracts, without regard to religion or national origin. (b... religion and/or national origin. These guidelines are intended to remedy such unfair treatment. (c) These...

41 CFR 60-50.1 - Purpose and scope.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 50-GUIDELINES ON DISCRIMINATION BECAUSE OF RELIGION OR NATIONAL ORIGIN § 60-50.1 Purpose and scope... performing under federally assisted construction contracts, without regard to religion or national origin. (b... religion and/or national origin. These guidelines are intended to remedy such unfair treatment. (c) These...

41 CFR 60-50.1 - Purpose and scope.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 50-GUIDELINES ON DISCRIMINATION BECAUSE OF RELIGION OR NATIONAL ORIGIN § 60-50.1 Purpose and scope... performing under federally assisted construction contracts, without regard to religion or national origin. (b... religion and/or national origin. These guidelines are intended to remedy such unfair treatment. (c) These...

41 CFR 60-50.1 - Purpose and scope.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 50-GUIDELINES ON DISCRIMINATION BECAUSE OF RELIGION OR NATIONAL ORIGIN § 60-50.1 Purpose and scope... performing under federally assisted construction contracts, without regard to religion or national origin. (b... religion and/or national origin. These guidelines are intended to remedy such unfair treatment. (c) These...

41 CFR 60-50.1 - Purpose and scope.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 50-GUIDELINES ON DISCRIMINATION BECAUSE OF RELIGION OR NATIONAL ORIGIN § 60-50.1 Purpose and scope... performing under federally assisted construction contracts, without regard to religion or national origin. (b... religion and/or national origin. These guidelines are intended to remedy such unfair treatment. (c) These...

Coulomb Excitation of the N = 50 nucleus 80Zn

NASA Astrophysics Data System (ADS)

van de Walle, J.; Aksouh, F.; Ames, F.; Behrens, T.; Bildstein, V.; Blazhev, A.; Cederkäll, J.; Clément, E.; Cocolios, T. E.; Davinson, T.; Delahaye, P.; Eberth, J.; Ekström, A.; Fedorov, D. V.; Fedosseev, V. N.; Fraile, L. M.; Franchoo, S.; Gernhauser, R.; Georgiev, G.; Habs, D.; Heyde, K.; Huber, G.; Huyse, M.; Ibrahim, F.; Ivanov, O.; Iwanicki, J.; Jolie, J.; Kester, O.; Köster, U.; Kröll, T.; Krücken, R.; Lauer, M.; Lisetskiy, A. F.; Lutter, R.; Marsh, B. A.; Mayet, P.; Niedermaier, O.; Nilsson, T.; Pantea, M.; Perru, O.; Raabe, R.; Reiter, P.; Sawicka, M.; Scheit, H.; Schrieder, G.; Schwalm, D.; Seliverstov, M. D.; Sieber, T.; Sletten, G.; Smirnova, N.; Stanoiu, M.; Stefanescu, I.; Thomas, J.-C.; Valiente-Dobón, J. J.; van Duppen, P.; Verney, D.; Voulot, D.; Warr, N.; Weisshaar, D.; Wenander, F.; Wolf, B. H.; Zielińska, M.

2008-05-01

Neutron rich Zinc isotopes, including the N = 50 nucleus 80Zn, were produced and post-accelerated at the Radioactive Ion Beam (RIB) facility REX-ISOLDE (CERN). Low-energy Coulomb excitation was induced on these isotopes after post-acceleration, yielding B(E2) strengths to the first excited 2+ states. For the first time, an excited state in 80Zn was observed and the 21+ state in 78Zn was established. The measured B(E2,21+-->01+) values are compared to two sets of large scale shell model calculations. Both calculations reproduce the observed B(E2) systematics for the full Zinc isotopic chain. The results for N = 50 isotones indicate a good N = 50 shell closure and a strong Z = 28 proton core polarization. The new results serve as benchmarks to establish theoretical models, predicting the nuclear properties of the doubly magic nucleus 78Ni.

A Robust 96.6-dB-SNDR 50-kHz-Bandwidth Switched-Capacitor Delta-Sigma Modulator for IR Imagers in Space Instrumentation.

PubMed

Dei, Michele; Sutula, Stepan; Cisneros, Jose; Pun, Ernesto; Jansen, Richard Jan Engel; Terés, Lluís; Serra-Graells, Francisco

2017-06-02

Infrared imaging technology, used both to study deep-space bodies' radiation and environmental changes on Earth, experienced constant improvements in the last few years, pushing data converter designers to face new challenges in terms of speed, power consumption and robustness against extremely harsh operating conditions. This paper presents a 96.6-dB-SNDR (Signal-to-Noise-plus-Distortion Ratio) 50-kHz-bandwidth fourth-order single-bit switched-capacitor delta-sigma modulator for ADC operating at 1.8 V and consuming 7.9 mW fit for space instrumentation. The circuit features novel Class-AB single-stage switched variable-mirror amplifiers (SVMAs) enabling low-power operation, as well as low sensitivity to both process and temperature deviations for the whole modulator. The physical implementation resulted in a 1.8-mm 2 chip integrated in a standard 0.18-µm 1-poly-6-metal (1P6M) CMOS technology, and it reaches a 164.6-dB Schreier figure of merit from experimental SNDR measurements without making use of any clock bootstrapping,analogcalibration,nordigitalcompensationtechnique. Whencoupledtoa2048×2048 IR imager, the current design allows more than 50 frames per minute with a resolution of 16 effective number of bits (ENOB) while consuming less than 300 mW.

50 CFR 622.37 - Size limits.

Code of Federal Regulations, 2014 CFR

2014-10-01

....38 (b)(3) and 13 inches (33.0 cm), TL, for a fish taken by a person not subject to the bag limit. (2) Lane snapper—8 inches (20.3 cm), TL. (3) Vermilion snapper—10 inches (25.4 cm), TL. (4) Cubera, gray... in § 622.38(b)(2)—20 inches (50.8 cm), TL. (3) Scamp—16 inches (40.6 cm), TL. (4) Yellowfin grouper...

50 CFR 622.37 - Size limits.

Code of Federal Regulations, 2013 CFR

2013-10-01

....38 (b)(3) and 13 inches (33.0 cm), TL, for a fish taken by a person not subject to the bag limit. (2) Lane snapper—8 inches (20.3 cm), TL. (3) Vermilion snapper—10 inches (25.4 cm), TL. (4) Cubera, gray... in § 622.38(b)(2)—20 inches (50.8 cm), TL. (3) Scamp—16 inches (40.6 cm), TL. (4) Yellowfin grouper...

40 CFR 50.2 - Scope.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS NATIONAL PRIMARY AND SECONDARY AMBIENT AIR QUALITY STANDARDS § 50.2 Scope. (a) National primary and secondary ambient air quality standards under section 109 of the Act are set forth in this part. (b) National primary ambient air quality...

How to implement decoy-state quantum key distribution for a satellite uplink with 50-dB channel loss

NASA Astrophysics Data System (ADS)

Meyer-Scott, Evan; Yan, Zhizhong; MacDonald, Allison; Bourgoin, Jean-Philippe; Hübel, Hannes; Jennewein, Thomas

2011-12-01

Quantum key distribution (QKD) takes advantage of fundamental properties of quantum physics to allow two distant parties to share a secret key; however, QKD is hampered by a distance limitation of a few hundred kilometers on Earth. The most immediate solution for global coverage is to use a satellite, which can receive separate QKD transmissions from two or more ground stations and act as a trusted node to link these ground stations. In this article we report on a system capable of performing QKD in the high loss regime expected in an uplink to a satellite using weak coherent pulses and decoy states. Such a scenario profits from the simplicity of its receiver payload, but has so far been considered to be infeasible due to very high transmission losses (40-50 dB). The high loss is overcome by implementing an innovative photon source and advanced timing analysis. Our system handles up to 57 dB photon loss in the infinite key limit, confirming the viability of the satellite uplink scenario. We emphasize that while this system was designed with a satellite uplink in mind, it could just as easily overcome high losses on any free space QKD link.

Rolling Contact Fatigue Life and Spall Propagation Characteristics of AISI M50, M50 NiL, and AISI 52100. Part 3. Metallurgical Examination (Preprint)

DTIC Science & Technology

2009-10-01

bearing materials, namely AISI 52100, VIM-VAR M50 , and VIM-VAR M50 NiL steels . While...propagation characteristics of three bearing materials, namely AISI 52100, VIM-VAR M50 , and VIM-VAR M50 NiL steels . While there is substantial prior work...deformation from run in. Residual stress profiles for bearing 075B are shown in Figure 3. The bearing is made from M50 steel and the spall

46 CFR 112.50-7 - Compressed air starting.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 46 Shipping 4 2013-10-01 2013-10-01 false Compressed air starting. 112.50-7 Section 112.50-7... air starting. A compressed air starting system must meet the following: (a) The starting, charging... air compressors addressed in paragraph (c)(3)(i) of this section. (b) The compressed air starting...

46 CFR 112.50-7 - Compressed air starting.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 46 Shipping 4 2014-10-01 2014-10-01 false Compressed air starting. 112.50-7 Section 112.50-7... air starting. A compressed air starting system must meet the following: (a) The starting, charging... air compressors addressed in paragraph (c)(3)(i) of this section. (b) The compressed air starting...

Establishing Operational Access: Insights from the Past for the Future

DTIC Science & Technology

2014-06-01

Combined Bomber Offensive, the Yom Kippur War, and Operation Mole Cricket 19 identifies two tenets that must be incorporated into the next iteration of...Mole Cricket 19 identifies two tenets that must be incorporated into the next iteration of the Joint Operational Access Concept. First, the Joint...They are the Battle of Britain, the Combined Bomber Offensive, the Yom Kippur War, and Operation Mole Cricket 19. These examples were selected

Nuclear Weapons: The Reliable Replacement Warhead Program

DTIC Science & Technology

2005-07-20

time to age. The United States introduced generation after generation of new nuclear “delivery vehicles ” — bombers, missile submarines, and land...less constrained in weight because bombers carry heavier loads than missiles. 26 Ballistic missiles carry warheads inside reentry vehicles (RVs). An...RV is a streamlined shell that protects its warhead from the intense heat and other stresses of reentering the atmosphere at high speed. RVs are

50 CFR 300.66 - Prohibitions.

Code of Federal Regulations, 2012 CFR

2012-10-01

... accordance with the annual management measures published pursuant to 50 CFR 300.62. (b) Fish for halibut except in accordance with the catch sharing plans and domestic management measures implemented under... while commercial fishing or from sport fishing, as defined at § 300.61, except that persons authorized...

50 CFR 300.66 - Prohibitions.

Code of Federal Regulations, 2013 CFR

2013-10-01

... accordance with the annual management measures published pursuant to 50 CFR 300.62. (b) Fish for halibut except in accordance with the catch sharing plans and domestic management measures implemented under... while commercial fishing or from sport fishing, as defined at § 300.61, except that persons authorized...

50 CFR 300.66 - Prohibitions.

Code of Federal Regulations, 2014 CFR

2014-10-01

... accordance with the annual management measures published pursuant to 50 CFR 300.62. (b) Fish for halibut except in accordance with the catch sharing plans and domestic management measures implemented under... subsistence fishing for halibut while commercial fishing or sport fishing, as defined in § 300.61, from the...

50 CFR 300.66 - Prohibitions.

Code of Federal Regulations, 2011 CFR

2011-10-01

... accordance with the annual management measures published pursuant to 50 CFR 300.62. (b) Fish for halibut except in accordance with the catch sharing plans and domestic management measures implemented under... while commercial fishing or from sport fishing, as defined at § 300.61, except that persons authorized...

Vitamin C and Vitamin E Protected B95-8 and Balb/c-3T3 Cells from Apoptosis Induced by Intermittent 50Hz ELF-EMF Radiation

PubMed Central

DING, Zhen; LI, Jintao; LI, Fan; MEPHRYAR, Mohammadreza Mohammadzad; WU, Shuicai; ZHANG, Chen; ZENG, Yi

2017-01-01

Background: The extremely low-frequency electromagnetic field (ELF-EMF), mainly emitted by electric transmission lines and household electronic appliances, is becoming a worldwide health risk. It is imperative to investigate the biological impacts of ELF-EMF and to identify products that are resistant to the radiation from 50 Hz ELF-EMF. In this study, we investigated the biological impacts of apoptosis caused by 50 Hz Power line ELF-EMF and the protective effects of Vit C and Vit E. Methods: We conducted this study in Beijing, China in 2013. B95-8 and Balb/c-3T3 cells were divided into a sham group, an expo group and 3 expo groups in which the cells were preincubated with various concentrations of Vit C and Vit E. Then, all of the cells were exposed to 50 Hz Power line ELF-EMF and examined for apoptosis. The cells were collected for apoptosis detection after exposure. Results: The percent of cells that undergoing apoptosis and preincubated with various concentrations of Vit C and Vit E were significantly lower than in the Expo group. Conclusion: Vit C and Vit E exert significant protective effects from 50 Hz ELF-EMF radiation. The optimal protective concentrations of Vit C and Vit E are 10 μmol/L and 25 μmol/L, respectively. The protective effect of vitamins was more apparent for Balb/c-3T3 cells than B95-8 cells. PMID:28451526

Vitamin C and Vitamin E Protected B95-8 and Balb/c-3T3 Cells from Apoptosis Induced by Intermittent 50Hz ELF-EMF Radiation.

PubMed

Ding, Zhen; Li, Jintao; Li, Fan; Mephryar, Mohammadreza Mohammadzad; Wu, Shuicai; Zhang, Chen; Zeng, Yi

2017-01-01

The extremely low-frequency electromagnetic field (ELF-EMF), mainly emitted by electric transmission lines and household electronic appliances, is becoming a worldwide health risk. It is imperative to investigate the biological impacts of ELF-EMF and to identify products that are resistant to the radiation from 50 Hz ELF-EMF. In this study, we investigated the biological impacts of apoptosis caused by 50 Hz Power line ELF-EMF and the protective effects of Vit C and Vit E. We conducted this study in Beijing, China in 2013. B 95-8 and Balb/c-3T3 cells were divided into a sham group, an expo group and 3 expo groups in which the cells were preincubated with various concentrations of Vit C and Vit E. Then, all of the cells were exposed to 50 Hz Power line ELF-EMF and examined for apoptosis. The cells were collected for apoptosis detection after exposure. The percent of cells that undergoing apoptosis and preincubated with various concentrations of Vit C and Vit E were significantly lower than in the Expo group. Vit C and Vit E exert significant protective effects from 50 Hz ELF-EMF radiation. The optimal protective concentrations of Vit C and Vit E are 10 μmol/L and 25 μmol/L, respectively. The protective effect of vitamins was more apparent for Balb/c-3T3 cells than B 95-8 cells.

Mercury (II) removal by resistant bacterial isolates and mercuric (II) reductase activity in a new strain of Pseudomonas sp. B50A.

PubMed

Giovanella, Patricia; Cabral, Lucélia; Bento, Fátima Menezes; Gianello, Clesio; Camargo, Flávio Anastácio Oliveira

2016-01-25

This study aimed to isolate mercury resistant bacteria, determine the minimum inhibitory concentration for Hg, estimate mercury removal by selected isolates, explore the mer genes, and detect and characterize the activity of the enzyme mercuric (II) reductase produced by a new strain of Pseudomonas sp. B50A. The Hg removal capacity of the isolates was determined by incubating the isolates in Luria Bertani broth and the remaining mercury quantified by atomic absorption spectrophotometry. A PCR reaction was carried out to detect the merA gene and the mercury (II) reductase activity was determined in a spectrophotometer at 340 nm. Eight Gram-negative bacterial isolates were resistant to high mercury concentrations and capable of removing mercury, and of these, five were positive for the gene merA. The isolate Pseudomonas sp. B50A removed 86% of the mercury present in the culture medium and was chosen for further analysis of its enzyme activity. Mercuric (II) reductase activity was detected in the crude extract of this strain. This enzyme showed optimal activity at pH 8 and at temperatures between 37 °C and 45 °C. The ions NH4(+), Ba(2+), Sn(2+), Ni(2+) and Cd(2+) neither inhibited nor stimulated the enzyme activity but it decreased in the presence of the ions Ca(2+), Cu(+) and K(+). The isolate and the enzyme detected were effective in reducing Hg(II) to Hg(0), showing the potential to develop bioremediation technologies and processes to clean-up the environment and waste contaminated with mercury. Copyright © 2015 Elsevier B.V. All rights reserved.

31 CFR 50.20 - General mandatory availability requirements.

Code of Federal Regulations, 2011 CFR

2011-07-01

... requirements. 50.20 Section 50.20 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... from events other than acts of terrorism. (b) Program Year 3—calendar year 2005. In accordance with the... the policy period of insurance coverage for losses from events other than acts of terrorism extends...

31 CFR 50.20 - General mandatory availability requirements.

Code of Federal Regulations, 2014 CFR

2014-07-01

... requirements. 50.20 Section 50.20 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... from events other than acts of terrorism. (b) Program Year 3—calendar year 2005. In accordance with the... the policy period of insurance coverage for losses from events other than acts of terrorism extends...

31 CFR 50.20 - General mandatory availability requirements.

Code of Federal Regulations, 2013 CFR

2013-07-01

... requirements. 50.20 Section 50.20 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... from events other than acts of terrorism. (b) Program Year 3—calendar year 2005. In accordance with the... the policy period of insurance coverage for losses from events other than acts of terrorism extends...

31 CFR 50.20 - General mandatory availability requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... requirements. 50.20 Section 50.20 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... from events other than acts of terrorism. (b) Program Year 3—calendar year 2005. In accordance with the... the policy period of insurance coverage for losses from events other than acts of terrorism extends...

Reliability Modeling of Critical Electronic Devices.

DTIC Science & Technology

1983-05-01

form are given below: 1) Xn = K 7E = AS + B 2) Xn = K TTE = A(S)B 3) Xn = K TE = A exp(BS) 24 A- where Xn = predicted normalized failure rate 0 0 K...naval, sheltered NS 5 7.3 a,. naval, unsheltered NU 10 16.8 naval, undersea , unsheltered NUU 14 20.6 naval, benign, submarine NSB 4 6.0 naval, hydrofoil... undersea , launch USL 18 37.1 3 S missile, free flight MFF 9 12.6 airbreathing missile, flight MFA 11 17.6 space, flight SF 2 2.1 Notes: (1) includes bomber

Program Budgeting within the Department of the Navy

DTIC Science & Technology

1989-06-01

incremental increases in bidgets . When a popular call goes out for a 600 ship navy, a strategic defense initiative, or a B-2 bomber, this is the time...Previously defense budgets had been formulated by j focusing on the existing base and adding incremental improvements to it. The whole question of how much a...the aggregate budgets appeared to change in smooth increments , they found great variations in the budgets of the agencies which make up the DOA. They

An Analysis of Tank Gap in Military Balance between Republic of Korea and North Korea

DTIC Science & Technology

1989-12-01

designation *1100-3B CD850-6 CD850-6A Type hydrokinetic crossdrive No. of gears (forward/reverse) 4/2 2/2 2/1 Steering system hydrostatic crossdrive hydro...increased the number of bombers supplied to NK, and by 1956 they had introduced a new aircraft weapon system , the MIG-17 fighters. The agreement stood...U.S. inventories. Additionally, these arms were single weapons (as opposed to weapons systems ) which required only minimal mainte- nance and limited

Electromagnetic Scattering from a Structured Slab Comprised of Periodically Placed Resistive Cards

DTIC Science & Technology

1989-05-01

many different configurations of resistance may be computed at little additional cost. The three types of elements in the tridiagonal resistance...that of the B-52 bomber Reduction of the RCS is a hierarchical process in which each level of contribution must be taken care of by a different ...between the 3 currents of different unit cells; the currents on the entire structure must be treated as unknowns in a moment method solution. On the other

Utility of de-escalatory confidence-building measures

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nation, J.

1989-06-01

This paper evaluates the utility of specific confidence-building de-escalatory measures and pays special attention to the evaluation of measures which place restrictions on or establish procedures for strategic forces. Some measures appear more promising than others. Potentially useful confidence-building measures largely satisfy defined criteria and include the phased return of strategic nuclear forces to peacetime bases and operations, the termination of interference with communications and NTMs (National Technical Means) and the termination of civil defense preparations. Less-promising CBMs include the standing down of supplemental early warning systems, the establishment of SSBN keep-out zones, and decreases in bomber alert rates. Establishmentmore » of SSBN keep-out zones and reduction in bomber rates are difficult to verify, while the standing-down of early warning systems provides little benefit at potentially large costs. Particular confidence-building measures (CBMs) may be most useful in building superpower confidence at specific points in the crisis termination phase. For example, a decrease in strategic bomber alert rates may provide some decrease in perception of the likelihood of war, but its potential costs, particularly in increasing bomber vulnerability, may limit its utility and implementation to the final crisis stages when the risks of re-escalation and surprise attack are lower.« less

31 CFR 50.18 - Notice required by reinstatement provision.

Code of Federal Regulations, 2013 CFR

2013-07-01

... provision. 50.18 Section 50.18 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... reinstatement provision. (a) Nullification of terrorism exclusion. Any terrorism exclusion in a contract for... losses that would otherwise be insured losses. (b) Reinstatement of terrorism exclusion. Notwithstanding...

31 CFR 50.18 - Notice required by reinstatement provision.

Code of Federal Regulations, 2012 CFR

2012-07-01

... provision. 50.18 Section 50.18 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... reinstatement provision. (a) Nullification of terrorism exclusion. Any terrorism exclusion in a contract for... losses that would otherwise be insured losses. (b) Reinstatement of terrorism exclusion. Notwithstanding...

31 CFR 50.18 - Notice required by reinstatement provision.

Code of Federal Regulations, 2014 CFR

2014-07-01

... provision. 50.18 Section 50.18 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... reinstatement provision. (a) Nullification of terrorism exclusion. Any terrorism exclusion in a contract for... losses that would otherwise be insured losses. (b) Reinstatement of terrorism exclusion. Notwithstanding...

31 CFR 50.18 - Notice required by reinstatement provision.

Code of Federal Regulations, 2011 CFR

2011-07-01

... provision. 50.18 Section 50.18 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM... reinstatement provision. (a) Nullification of terrorism exclusion. Any terrorism exclusion in a contract for... losses that would otherwise be insured losses. (b) Reinstatement of terrorism exclusion. Notwithstanding...

41 CFR 109-40.305-50 - Negotiations involving national security.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false Negotiations involving national security. 109-40.305-50 Section 109-40.305-50 Public Contracts and Property Management Federal... Management § 109-40.305-50 Negotiations involving national security. Title 49 U.S.C., section 10721(b)(2...

41 CFR 109-40.305-50 - Negotiations involving national security.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Negotiations involving national security. 109-40.305-50 Section 109-40.305-50 Public Contracts and Property Management Federal... Management § 109-40.305-50 Negotiations involving national security. Title 49 U.S.C., section 10721(b)(2...

41 CFR 109-40.305-50 - Negotiations involving national security.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Negotiations involving national security. 109-40.305-50 Section 109-40.305-50 Public Contracts and Property Management Federal... Management § 109-40.305-50 Negotiations involving national security. Title 49 U.S.C., section 10721(b)(2...

41 CFR 109-40.305-50 - Negotiations involving national security.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Negotiations involving national security. 109-40.305-50 Section 109-40.305-50 Public Contracts and Property Management Federal... Management § 109-40.305-50 Negotiations involving national security. Title 49 U.S.C., section 10721(b)(2...

41 CFR 109-40.305-50 - Negotiations involving national security.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false Negotiations involving national security. 109-40.305-50 Section 109-40.305-50 Public Contracts and Property Management Federal... Management § 109-40.305-50 Negotiations involving national security. Title 49 U.S.C., section 10721(b)(2...

Closing the Guantanamo Detention Center: Legal Issues

DTIC Science & Technology

2011-03-28

involvement in the failed Christmas Day bomb attack on an airline landing in Detroit, the United States “will not be transferring additional detainees back to...bomber Faisal Shahzad and suspected Detroit airline bomber Umar Farouk Abdulmutallab prior to the reading of their Miranda rights.175 An FBI...Article 43 provision allowing suspension of statute of limitations); United States v. Taylor, 15 C.M.R. 232 (1954) ( Korean conflict was “in time of war

The Bombing of Brittany: Solving the Wrong Problem

DTIC Science & Technology

2010-05-21

Record (South Yorkshire : Pen & Sword Books Ltd , 2005), 7. 30 Hastings, 126; Dudley Saward, Bomber Harris: The Story of Sir Arthur Harris, Marshal of the...Frank Cass and Co Ltd , 1995), 14-15. 76 Clout, 167. 77 Davis. Excel spreadsheets of bombing data from 1940-1945. 78 Williamson, 48. 79 Clout, 167...Ken. RAF Bomber Command 1936-1968: An Opertional and Historical Record. South Yorkshire : Pen & Sword Books Ltd , 2005. Dodd, Lindsey and Andrew

Nuclear Weapons: The Reliable Replacement Warhead Program

DTIC Science & Technology

2005-06-23

delivery vehicles ” — bombers, missile submarines, and land-based missiles — each of which would typically carry a new-design warhead tailored to its...weight because bombers carry heavier loads than missiles. 26 Ballistic missiles carry warheads inside reentry vehicles (RVs). An RV is a streamlined...shell that protects its warhead from the intense heat and other stresses of reentering the atmosphere at high speed. RVs are designed to carry a

40 CFR 166.50 - Reporting and recordkeeping requirements for crisis exemption.

Code of Federal Regulations, 2010 CFR

2010-07-01

... requirements for crisis exemption. 166.50 Section 166.50 Protection of Environment ENVIRONMENTAL PROTECTION... EMERGENCY CONDITIONS Crisis Exemptions § 166.50 Reporting and recordkeeping requirements for crisis... a crisis exemption must be immediately reported to the Agency. (b) Final reports. (1) A report...

40 CFR 790.50 - Submission of study plans.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 31 2010-07-01 2010-07-01 true Submission of study plans. 790.50..., Enforcement, and Modification of Test Rules § 790.50 Submission of study plans. (a) Who must submit study... of a single phase test rule as described in § 790.40(b)(1) must submit study plans for those tests...

40 CFR 790.50 - Submission of study plans.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 32 2011-07-01 2011-07-01 false Submission of study plans. 790.50..., Enforcement, and Modification of Test Rules § 790.50 Submission of study plans. (a) Who must submit study... of a single phase test rule as described in § 790.40(b)(1) must submit study plans for those tests...

50 CFR 648.72 - Minimum surf clam size.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Atlantic Surf Clam and Ocean Quahog Fisheries § 648.72 Minimum surf clam size. (a) Minimum length. The minimum length for surf clams is 4.75 inches (12.065 cm). (b) Determination of compliance. No more than 50... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Minimum surf clam size. 648.72 Section 648...

An update on 11B,10B fractionation in the fundamental reaction: 10B(OH)3 + 11B(OH)4- = 11B(OH)3 + 10B(OH)4-

NASA Astrophysics Data System (ADS)

Klochko, K.; Tossell, J. A.

2007-12-01

It has recently been demonstrated experimentally by Byrne, et al. (2006) and Klochko, et al. (2006) that the equilibrium constant for the isotopic exchange reaction: 10B(OH)3 + 11B(OH)4- = 11B(OH)3 + 10B(OH)4- (1) has a value around 1.027 for seawater at 25°C, for total B concentrations from 0.01 to 0.05 molal. These experimental studies involved essentially the accurate determination of the small pKa difference between the 11B and 10B isotopomers of boric acid. This new equilibrium constant value is significantly higher than the traditional value of 1.0194 from Kakihana, et al. (1977). This result has been obscured in recent controversies (Honisch, et al., 2007). The new value agrees well with the ab initio quantum cluster calculated values of Liu and Tossell (2005) and with the ab initio MD harmonic values of Rustad and Bylaska (2007). We will present additional calculations supporting and extending the study of Liu and Tossell (2005) and will discuss the general unsuitability of methods such as Sanchez-Valle, et al. (2005) which employ experimental spectral data. We have also established that polyborate formation in solutions as concentrated as 0.50 molal total B has little effect on the equilibrium constant. A mechanism is also presented for the interaction of B(OH)3 and B(OH)4- with HCO3- species occurring on the calcite surface. References: Byrne, et al. Deep-Sea Research I (2006) 53, 684-688. Honisch, et al. Geochim. Cosmochim. Acta (2007) 71, 1636-1641. Kakihana, et al. Bull. Chem. Soc. Jpn. (1977) 50, 158-163. Klochko, et al. Earth Planet. Sci. Lett. (2006) 248, 276-285. Liu and Tossell Geochim. Cosmochim. Acta (2005) 69, 3995-4006. Rustad and Bylaska J. Am. Chem. Soc. (2007) 129, 2222-2223. Sanchez-Valle, et al. Geochim. Cosmochim. Acta (2005) 69, 4301-4313.

B-52 Flight Mission Symbology - Close up

NASA Technical Reports Server (NTRS)

1993-01-01

A close-up view of some of the mission markings that tell the story of the NASA B-52 mothership's colorful history. These particular markings denote some of the experiments the bomber conducted to develop parachute recovery systems for the solid rocket boosters used by the Space Shuttle. NASA B-52, Tail Number 008, is an air launch carrier aircraft, 'mothership,' as well as a research aircraft platform that has been used on a variety of research projects. The aircraft, a 'B' model built in 1952 and first flown on June 11, 1955, is the oldest B-52 in flying status and has been used on some of the most significant research projects in aerospace history. Some of the significant projects supported by B-52 008 include the X-15, the lifting bodies, HiMAT (highly maneuverable aircraft technology), Pegasus, validation of parachute systems developed for the space shuttle program (solid-rocket-booster recovery system and the orbiter drag chute system), and the X-38. The B-52 served as the launch vehicle on 106 X-15 flights and flew a total of 159 captive-carry and launch missions in support of that program from June 1959 to October 1968. Information gained from the highly successful X-15 program contributed to the Mercury, Gemini, and Apollo human spaceflight programs as well as space shuttle development. Between 1966 and 1975, the B-52 served as the launch aircraft for 127 of the 144 wingless lifting body flights. In the 1970s and 1980s, the B-52 was the launch aircraft for several aircraft at what is now the Dryden Flight Research Center, Edwards, California, to study spin-stall, high-angle-of attack, and maneuvering characteristics. These included the 3/8-scale F-15/spin research vehicle (SRV), the HiMAT (Highly Maneuverable Aircraft Technology) research vehicle, and the DAST (drones for aerodynamic and structural testing). The aircraft supported the development of parachute recovery systems used to recover the space shuttle solid rocket booster casings. It also supported

Optimizing the post-START (Strategic Arms Reduction Treaty) US strategic nuclear force mix. Master's thesis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leary, D.A.

1989-06-01

This thesis examines the impact a START agreement might have on the United States and Soviet strategic nuclear forces. It then proposes an optimum post-START force mix for the United States and the Soviet Union. The current, as well as projected, post-START targeting policies are discussed. It is concluded that the impact of a START agreement on the current U.S. strategic targeting policy will be minimal. Although the target data base will not shrink as much as the forces tasked to cover it, a prioritization of targets is all that should be necessary with a post-START force. A START agreementmore » will mean major reductions in U.S. and Soviet strategic nuclear forces. As proposed in this thesis, only the ICBM leg of the Triad will require any major re-structuring. This would include the addition of mobile ICBM systems. The SLBM and bomber legs will feel minimal changes (i.e., retiring POSEIDON SSBNs and retiring or converting some older B-52s). It is recommended that the B-52 program be cancelled, and funding be re-directed into mobile ICBM systems. By doing so the United States could utilize technology available today to strengthen its forces and not gamble on the low-observable technology which a stealth bomber might have.« less

NASA Dryden research pilot Gordon Fullerton flies his final mission in NASA F/A-18B #852 in formation with NASA F/A-18A #850 on Dec. 21, 2007.

NASA Image and Video Library

2007-12-21

Long-time NASA Dryden research pilot and former astronaut C. Gordon Fullerton capped an almost 50-year flying career, including more than 38 years with NASA, with a final flight in a NASA F/A-18 on Dec. 21, 2007. Fullerton and Dryden research pilot Jim Smolka flew a 90-minute pilot proficiency formation aerobatics flight with another Dryden F/A-18 and a Dryden T-38 before concluding with two low-level formation flyovers of Dryden before landing. Fullerton was honored with a water-cannon spray arch provided by two fire trucks from the Edwards Air Force Base fire department as he taxied the F/A-18 up to the Dryden ramp, and was then greeted by his wife Marie and several hundred Dryden staff after his final flight. Fullerton began his flying career with the U.S. Air Force in 1958 after earning bachelor's and master's degrees in mechanical engineering from the California Institute of Technology. Initially trained as a fighter pilot, he later transitioned to multi-engine bombers and became a bomber operations test pilot after attending the Air Force Aerospace Research Pilot School at Edwards Air Force Base, Calif. He then was assigned to the flight crew for the planned Air Force Manned Orbital Laboratory in 1966. Upon cancellation of that program, the Air Force assigned Fullerton to NASA's astronaut corps in 1969. He served on the support crews for the Apollo 14, 15, 16 and 17 lunar missions, and was later assigned to one of the two flight crews that piloted the space shuttle prototype Enterprise during the Approach and Landing Test program at Dryden. He then logged some 382 hours in space when he flew on two early space shuttle missions, STS-3 on Columbia in 1982 and STS-51F on Challenger in 1985. He joined the flight crew branch at NASA Dryden after leaving the astronaut corps in 1986. During his 21 years at Dryden, Fullerton was project pilot on a number of high-profile research efforts, including the Propulsion Controlled Aircraft, the high-speed landing tests of sp

31 CFR 50.5 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-07-01

... and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.5 Definitions. For purposes of this Part: (a) Act means the Terrorism Risk Insurance Act of 2002. (b) Act of terrorism—(1) In general. The term act of terrorism means any act that is certified by...

31 CFR 50.5 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.5 Definitions. For purposes of this Part: (a) Act means the Terrorism Risk Insurance Act of 2002. (b) Act of terrorism—(1) In general. The term act of terrorism means any act that is certified by...

31 CFR 50.5 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.5 Definitions. For purposes of this Part: (a) Act means the Terrorism Risk Insurance Act of 2002. (b) Act of terrorism—(1) In general. The term act of terrorism means any act that is certified by...

31 CFR 50.5 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-07-01

... and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE PROGRAM General Provisions § 50.5 Definitions. For purposes of this Part: (a) Act means the Terrorism Risk Insurance Act of 2002. (b) Act of terrorism—(1) In general. The term act of terrorism means any act that is certified by...

Inhibition of monoamine oxidase B (MAO-B) by Chinese herbal medicines.

PubMed

Lin, R D; Hou, W C; Yen, K Y; Lee, M H

2003-11-01

Monoamine oxidase (MAO) catalyzes the oxidative deamination of biogenic amines accompaned by the release of H2O2. Two subtypes, MAO-A and MAO-B, exist on the basis of their specificities to substrates and inhibitors. The regulation of MAO-B activity is important in the treatment of neurodegenerative diseases. Twenty-seven species of plants used in traditional Chinese medicines, selected from an enthnobotanical survey, were used in an investigation of their inhibitory effect on MAO-B in rat brain homogenates. The 50% aqueous methanol extracts of four active extracts, Arisaema amurense, Lilium brownii var. colchesteri, Lycium chinense, and Uncaria rhynchophylla, exhibited the best activity and selectivity towards MAO-B with IC50 values of 0.44, 0.29, 0.40, and 0.03 mg/ml, respectively. A kinetic study of MAO-B inhibition by the four extracts using the Lineweaver-Burk plot for each active extract revealed the IC50 concentrations, and results show that: Ki = 0.59 mg/ml for A. amurense for the mixed-type mode, Ki = 0.58 mg/ml for L. brownii var. colchesteri for the mixed-type mode, Ki = 5.01 mg/ml for L. chinense for the uncompetitive mode, and Ki = 0.02 mg/ml for U. rhynchophylla for the uncompetitive mode. These may therefore be candidates for use in delaying the progressive degeneration caused by neurological diseases.

10 CFR 50.72 - Immediate notification requirements for operating nuclear power reactors.

Code of Federal Regulations, 2010 CFR

2010-01-01

... power reactors. 50.72 Section 50.72 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF... notification requirements for operating nuclear power reactors. (a) General requirements. 1 (1) Each nuclear power reactor licensee licensed under §§ 50.21(b) or 50.22 holding an operating license under this part...

10 CFR 50.72 - Immediate notification requirements for operating nuclear power reactors.

Code of Federal Regulations, 2011 CFR

2011-01-01

... power reactors. 50.72 Section 50.72 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING OF... notification requirements for operating nuclear power reactors. (a) General requirements. 1 (1) Each nuclear power reactor licensee licensed under §§ 50.21(b) or 50.22 holding an operating license under this part...

Establishing a Department of Defense Program Management Body of Knowledge

DTIC Science & Technology

1991-09-01

systems included, "...thousands of jet fighters, bombers and transport aircraft; one hundred new combat and support vessels; and thousands of tanks and...cannon-carrying troop transports and strategic and tactical missiles" (12:9). Such systems were designed to achieve goals and performance levels never...to L. A a 20-week Program Mnageme-.nt .ur., ’ DSMc b-,o : taking command of a mra or pLog-im. A Major De ?-n.5 Acquisition (Category I) Program in the

Armed Drones and Targeted Killing: Policy Implications for Their Use in Deterring Violent Extremism

DTIC Science & Technology

2017-04-17

launched some 200 pilotless balloons mounted with bombs against the city of Venice.”6 It was not until World War I, with the advent of radio...into World War II, weapons manufacturers began fitting them with bombs and explosives to give them a strike capability. Bombers, like the B-17...would release these “flying bombs ”, which were more akin to guided missiles, near a target area, and then a pilot would remotely guide the drone to its

With Courage: The U.S. Army Air Forces in World War II,

DTIC Science & Technology

1994-01-01

account of the contributions of American air power to victory in that war. A second commemoration in September 1997 marks the fiftieth birthday of the... cost at $31 million a year for the five-year plan and $26 million a year thereafter to maintain the force in a modernized and ready state. This would...American bomber of the decade, but its short range, limited useful load, and high cost made it a disappointment. The Keystone series of bombers, represented

Battlespace Representation for Air, Space, and Cyber

DTIC Science & Technology

2012-07-17

they were cardboard models of targets carried in the bombers to allow bombardiers to see how the target would look with current shadows. See Figure ...1 for an example. Command and control has changed as well as targeting. Figure 2 illustrates a WW II-era command center built in tunnels near...invariants that can be used to shape or guide designs. Figure 1. A cardboard model used by bombers. Command and control has changed as well as

Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-{kappa}B in mice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glauert, Howard P.; Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40506; Tharappel, Job C.

Polychlorinated biphenyls (PCBs) are persistent and ubiquitous environmental chemicals that bioaccumulate and have hepatic tumor promoting activity in rodents. The present study examined the effect of deleting the p50 subunit of NF-{kappa}B on the hepatic tumor promoting activity of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) in mice. Both wild-type and p50-/- male mice were injected i.p. with diethylnitrosamine (DEN, 90 mg/kg) and then subsequently injected biweekly with 20 i.p. injections of PCB-153 (300 {mu}mol/kg/injection). p50 deletion decreased the tumor incidence in both PCB- and vehicle-treated mice, whereas PCB-153 slightly (P = 0.09) increased the tumor incidence in wild-type and p50-/- mice. PCB-153 increased themore » total tumor volume in both wild-type and p50-/- mice, but the total tumor volume was not affected by p50 deletion in either PCB- or vehicle-treated mice. The volume of tumors that were positive for glutamine synthetase (GS), which is indicative of mutations in the beta-catenin gene, was increased in both wild-type and p50-/- mice administered PCB-153 compared to vehicle controls, and inhibited in p50-/- mice compared to wild-type mice (in both PCB- and vehicle-treated mice). The volume of tumors that were negative for GS was increased in p50-/- mice compared to wild-type mice but was not affected by PCB-153. PCB-153 increased cell proliferation in normal hepatocytes in wild-type but not p50-/- mice; this increase was inhibited in p50-/- mice. In hepatic tumors, the rate of cell proliferation was much higher than in normal hepatocytes, but was not affected by PCB treatment or p50 deletion. The rate of apoptosis, as measured by the TUNEL assay, was not affected by PCB-153 or p50 deletion in normal hepatocytes. In hepatic tumors, the rate of apoptosis was lower than in normal hepatocytes; PCB-153 slightly (P = 0.10) increased apoptosis in p50-/- but not wild-type mice; p50 deletion had no effect. Taken together, these data indicate that

Mice Deficient in NF-κB p50 and p52 or RANK Have Defective Growth Plate Formation and Post-natal Dwarfism.

PubMed

Xing, Lianping; Chen, Di; Boyce, Brendan F

2013-12-01

NF-κBp50/p52 double knockout (dKO) and RANK KO mice have no osteoclasts and develop severe osteopetrosis associated with dwarfism. In contrast, Op/Op mice, which form few osteoclasts, and Src KO mice, which have osteoclasts with defective resorptive function, are osteopetrotic, but they are not dwarfed. Here, we compared the morphologic features of long bones from p50/p52 dKO, RANK KO, Op/Op and Src KO mice to attempt to explain the differences in their long bone lengths. We found that growth plates in p50/p52 dKO and RANK KO mice are significantly thicker than those in WT mice due to a 2-3-fold increase in the hypertrophic chondrocyte zone associated with normal a proliferative chondrocyte zone. This growth plate abnormality disappears when animals become older, but their dwarfism persists. Op/Op or Src KO mice have relatively normal growth plate morphology. In-situ hybridization study of long bones from p50/p52 dKO mice showed marked thickening of the growth plate region containing type 10 collagen-expressing chondrocytes. Treatment of micro-mass chondrocyte cultures with RANKL did not affect expression levels of type 2 collagen and Sox9, markers for proliferative chondrocytes, but RANKL reduced the number of type 10 collagen-expressing hypertrophic chondrocytes. Thus, RANK/NF-κB signaling plays a regulatory role in post-natal endochondral ossification that maintains hypertrophic conversion and prevents dwarfism in normal mice.

46 CFR 95.50-10 - Location.

Code of Federal Regulations, 2013 CFR

2013-10-01

... Accommodations1 Staterooms, toilet spaces, public spaces, offices, lockers, isolated storerooms, and pantries... Extinguisher and Semiportable Fire-Extinguishing Systems Space Classification (see § 95.50-5) Quantity and... fraction thereof suitable for hazards involved. Paint and lamp rooms B-II 1 outside space in vicinity of...

46 CFR 95.50-10 - Location.

Code of Federal Regulations, 2012 CFR

2012-10-01

... Accommodations1 Staterooms, toilet spaces, public spaces, offices, lockers, isolated storerooms, and pantries... Extinguisher and Semiportable Fire-Extinguishing Systems Space Classification (see § 95.50-5) Quantity and... fraction thereof suitable for hazards involved. Paint and lamp rooms B-II 1 outside space in vicinity of...

46 CFR 95.50-10 - Location.

Code of Federal Regulations, 2011 CFR

2011-10-01

... Accommodations1 Staterooms, toilet spaces, public spaces, offices, lockers, isolated storerooms, and pantries... Extinguisher and Semiportable Fire-Extinguishing Systems Space Classification (see § 95.50-5) Quantity and... fraction thereof suitable for hazards involved. Paint and lamp rooms B-II 1 outside space in vicinity of...

46 CFR 95.50-10 - Location.

Code of Federal Regulations, 2014 CFR

2014-10-01

... Accommodations1 Staterooms, toilet spaces, public spaces, offices, lockers, isolated storerooms, and pantries... Extinguisher and Semiportable Fire-Extinguishing Systems Space Classification (see § 95.50-5) Quantity and... fraction thereof suitable for hazards involved. Paint and lamp rooms B-II 1 outside space in vicinity of...

Celebrating 50 Years of Testing

NASA Image and Video Library

2016-04-19

What better way to mark 50 years of rocket engine testing than with a rocket engine test? Stennis Space Center employees enjoyed a chance to view an RS-68 engine test at the B-1 Test Stand on April 19, almost 50 years to the day that the first test was conducted at the south Mississippi site in 1966. The test viewing was part of a weeklong celebration of the 50th year of rocket engine testing at Stennis. The first test at the site occurred April 23, 1966, with a 15-second firing of a Saturn V second stage prototype (S-II-C) on the A-2 Test Stand. The center subsequently tested Apollo rocket stages that carried humans to the moon and every main engine used to power 135 space shuttle missions. It currently tests engines for NASA’s new Space Launch System vehicle.

40 CFR 230.50 - Municipal and private water supplies.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 26 2013-07-01 2013-07-01 false Municipal and private water supplies. 230.50 Section 230.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING SECTION 404(b)(1) GUIDELINES FOR SPECIFICATION OF DISPOSAL SITES FOR DREDGED OR FILL MATERIAL Potential Effects on Human Use Characteristics §...

Suicide Bombers in CONUS

DTIC Science & Technology

2007-05-07

example, the 1972 attack at Tel Aviv’s Lod airport by three Japanese Red Army members (24 dead, 78 wounded) would not qualify as suicide terrorism, since...such actions as the massive Japanese kamikaze (divine wind) campaign near the end of World War II. To put the kamikaze effort in perspective, in...casualties as were suffered during the Pearl Harbor and 9/11 attacks combined. However, the Japanese tactic of using suicidal attackers was regarded

A Robust 96.6-dB-SNDR 50-kHz-Bandwidth Switched-Capacitor Delta-Sigma Modulator for IR Imagers in Space Instrumentation †

PubMed Central

Dei, Michele; Sutula, Stepan; Cisneros, Jose; Pun, Ernesto; Jansen, Richard Jan Engel; Terés, Lluís; Serra-Graells, Francisco

2017-01-01

Infrared imaging technology, used both to study deep-space bodies’ radiation and environmental changes on Earth, experienced constant improvements in the last few years, pushing data converter designers to face new challenges in terms of speed, power consumption and robustness against extremely harsh operating conditions. This paper presents a 96.6-dB-SNDR (Signal-to-Noise-plus-Distortion Ratio) 50-kHz-bandwidth fourth-order single-bit switched-capacitor delta-sigma modulator for ADC operating at 1.8 V and consuming 7.9 mW fit for space instrumentation. The circuit features novel Class-AB single-stage switched variable-mirror amplifiers (SVMAs) enabling low-power operation, as well as low sensitivity to both process and temperature deviations for the whole modulator. The physical implementation resulted in a 1.8-mm2 chip integrated in a standard 0.18-μm 1-poly-6-metal (1P6M) CMOS technology, and it reaches a 164.6-dB Schreier figure of merit from experimental SNDR measurements without making use of any clock bootstrapping, analog calibration, nor digital compensation technique. When coupled to a 2048×2048 IR imager, the current design allows more than 50 frames per minute with a resolution of 16 effective number of bits (ENOB) while consuming less than 300 mW. PMID:28574466

41 CFR 50-204.66 - Acetylene.

Code of Federal Regulations, 2010 CFR

2010-07-01

.... (b) The piped systems for the in-plant transfer and distribution of acetylene shall be designed..., Vapors, Fumes, Dusts, and Mists § 50-204.66 Acetylene. (a) The in-plant transfer, handling, storage, and...) Plants for the generation of acetylene and the charging (filling) of acetylene cylinders shall be...

10 CFR 50.36 - Technical specifications.

Code of Federal Regulations, 2013 CFR

2013-01-01

... nuclear reactors are limits upon important process variables that are found to be necessary to reasonably... Commission terminates the license for the reactor, except for nuclear power reactors licensed under § 50.21(b... for nuclear reactors are settings for automatic protective devices related to those variables having...

10 CFR 50.36 - Technical specifications.

Code of Federal Regulations, 2014 CFR

2014-01-01

... nuclear reactors are limits upon important process variables that are found to be necessary to reasonably... Commission terminates the license for the reactor, except for nuclear power reactors licensed under § 50.21(b... for nuclear reactors are settings for automatic protective devices related to those variables having...

10 CFR 50.36 - Technical specifications.

Code of Federal Regulations, 2012 CFR

2012-01-01

... nuclear reactors are limits upon important process variables that are found to be necessary to reasonably... Commission terminates the license for the reactor, except for nuclear power reactors licensed under § 50.21(b... for nuclear reactors are settings for automatic protective devices related to those variables having...

33 CFR 137.50 - Reviews of historical sources of information.

Code of Federal Regulations, 2013 CFR

2013-07-01

... information. 137.50 Section 137.50 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...: STANDARDS FOR CONDUCTING ALL APPROPRIATE INQUIRIES UNDER THE INNOCENT LAND-OWNER DEFENSE Standards and... insurance maps, building department records, chain of title documents, and land use records. (b) Historical...

33 CFR 137.50 - Reviews of historical sources of information.

Code of Federal Regulations, 2014 CFR

2014-07-01

... information. 137.50 Section 137.50 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...: STANDARDS FOR CONDUCTING ALL APPROPRIATE INQUIRIES UNDER THE INNOCENT LAND-OWNER DEFENSE Standards and... insurance maps, building department records, chain of title documents, and land use records. (b) Historical...

33 CFR 137.50 - Reviews of historical sources of information.

Code of Federal Regulations, 2011 CFR

2011-07-01

... information. 137.50 Section 137.50 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...: STANDARDS FOR CONDUCTING ALL APPROPRIATE INQUIRIES UNDER THE INNOCENT LAND-OWNER DEFENSE Standards and... insurance maps, building department records, chain of title documents, and land use records. (b) Historical...

33 CFR 137.50 - Reviews of historical sources of information.

Code of Federal Regulations, 2012 CFR

2012-07-01

... information. 137.50 Section 137.50 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...: STANDARDS FOR CONDUCTING ALL APPROPRIATE INQUIRIES UNDER THE INNOCENT LAND-OWNER DEFENSE Standards and... insurance maps, building department records, chain of title documents, and land use records. (b) Historical...

33 CFR 137.50 - Reviews of historical sources of information.

Code of Federal Regulations, 2010 CFR

2010-07-01

... information. 137.50 Section 137.50 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND...: STANDARDS FOR CONDUCTING ALL APPROPRIATE INQUIRIES UNDER THE INNOCENT LAND-OWNER DEFENSE Standards and... insurance maps, building department records, chain of title documents, and land use records. (b) Historical...

50 CFR Figures 14a and 14b to Part... - Maximum Angle of Deflector Bars With Straight Bars Attached to the Bottom of the Frame and...

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Maximum Angle of Deflector Bars With Straight Bars Attached to the Bottom of the Frame and Maximum Angle of Deflector Bars With Bent Bars Attached to the Bottom of the Frame 14a Figures 14a and 14b to Part 223 Wildlife and Fisheries NATIONAL...

50 CFR Figures 14a and 14b to Part... - Maximum Angle of Deflector Bars With Straight Bars Attached to the Bottom of the Frame and...

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Maximum Angle of Deflector Bars With Straight Bars Attached to the Bottom of the Frame and Maximum Angle of Deflector Bars With Bent Bars Attached to the Bottom of the Frame 14a Figures 14a and 14b to Part 223 Wildlife and Fisheries NATIONAL...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wilkening, D.A.

This paper discusses the extent to which bomber/cruise missile characteristics and activities can be monitored by national technical means (NTM). Particular attention is paid to those characteristics and activities relevant to arms control. National technical means--which refers to various technical means by which monitoring data can be gathered, usually involving satellite reconnaissance--are not the sole means for monitoring, though they may be the most dependable. This paper discusses the confidence one might have in monitoring bombers and cruise missiles.

CTC Sentinel. Volume 4 Number 1, January 2011

DTIC Science & Technology

2011-01-01

Muslims had been forced to wear the hijab . The ISoc also prevented Muslims from using an “interfaith prayer room,” a practice which they believed was...from terrorism in an al-Jazira broadcast in October 2004. This sense of immunity was shattered twice in December 2010. First, a suicide bomber...bomber before the attack, as he had studied and lived for a decade in the United Kingdom. At the same time, he admitted he had traveled to Iraq to

50 CFR 665.206 - Gear restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear restrictions. 665.206 Section 665.206..., DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES IN THE WESTERN PACIFIC Hawaii Fisheries § 665.206 Gear... MUS with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear. Possession of a...

50 CFR 404.10 - Commercial fishing.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Commercial fishing. 404.10 Section 404.10... MARINE NATIONAL MONUMENT § 404.10 Commercial fishing. (a) Lobster fishing. Any commercial lobster fishing permit is subject to a zero annual harvest limit condition. (b) Fishing and bottomfish and pelagic...

50 CFR 404.10 - Commercial fishing.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Commercial fishing. 404.10 Section 404.10... MARINE NATIONAL MONUMENT § 404.10 Commercial fishing. (a) Lobster fishing. Any commercial lobster fishing permit is subject to a zero annual harvest limit condition. (b) Fishing and bottomfish and pelagic...

50 CFR 404.10 - Commercial fishing.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Commercial fishing. 404.10 Section 404.10... MONUMENT § 404.10 Commercial fishing. (a) Lobster fishing. Any commercial lobster fishing permit is subject to a zero annual harvest limit condition. (b) Fishing and bottomfish and pelagic species. (1...

50 CFR 404.10 - Commercial fishing.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Commercial fishing. 404.10 Section 404.10... MARINE NATIONAL MONUMENT § 404.10 Commercial fishing. (a) Lobster fishing. Any commercial lobster fishing permit is subject to a zero annual harvest limit condition. (b) Fishing and bottomfish and pelagic...

50 CFR 404.10 - Commercial fishing.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Commercial fishing. 404.10 Section 404.10... MARINE NATIONAL MONUMENT § 404.10 Commercial fishing. (a) Lobster fishing. Any commercial lobster fishing permit is subject to a zero annual harvest limit condition. (b) Fishing and bottomfish and pelagic...

50 CFR 560.3 - Open meetings.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Open meetings. 560.3 Section 560.3....3 Open meetings. (a) Except as otherwise provided in this part, every portion of every meeting of the Commission shall be open to public observation. (b) Meetings of the Commission, or portions...

50 CFR 560.3 - Open meetings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Open meetings. 560.3 Section 560.3....3 Open meetings. (a) Except as otherwise provided in this part, every portion of every meeting of the Commission shall be open to public observation. (b) Meetings of the Commission, or portions...

50 CFR 560.3 - Open meetings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Open meetings. 560.3 Section 560.3....3 Open meetings. (a) Except as otherwise provided in this part, every portion of every meeting of the Commission shall be open to public observation. (b) Meetings of the Commission, or portions...

50 CFR 560.3 - Open meetings.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Open meetings. 560.3 Section 560.3....3 Open meetings. (a) Except as otherwise provided in this part, every portion of every meeting of the Commission shall be open to public observation. (b) Meetings of the Commission, or portions...

50 CFR 560.3 - Open meetings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Open meetings. 560.3 Section 560.3....3 Open meetings. (a) Except as otherwise provided in this part, every portion of every meeting of the Commission shall be open to public observation. (b) Meetings of the Commission, or portions...

Protective role of RAD50 on chromatin bridges during abnormal cytokinesis.

PubMed

Schröder-Heurich, Bianca; Wieland, Britta; Lavin, Martin F; Schindler, Detlev; Dörk, Thilo

2014-03-01

Faithful chromosome segregation is required for preserving genomic integrity. Failure of this process may entail chromatin bridges preventing normal cytokinesis. To test whether RAD50, a protein normally involved in DNA double-strand break repair, is involved in abnormal cytokinesis and formation of chromatin bridges, we used immunocytochemical and protein interaction assays. RAD50 localizes to chromatin bridges during aberrant cytokinesis and subsequent stages of the cell cycle, either decorating the entire bridge or focally accumulating at the midbody zone. Ionizing radiation led to an ∼4-fold increase in the rate of chromatin bridges in an ataxia telangiectatica mutated (ATM)-dependent manner in human RAD50-proficient fibroblasts but not in RAD50-deficient cells. Cells with a RAD50-positive chromatin bridge were able to continue cell cycling and to progress through S phase (44%), whereas RAD50 knockdown caused a deficiency in chromatin bridges as well as an ∼4-fold prolonged duration of mitosis. RAD50 colocalized and directly interacted with Aurora B kinase and phospho-histone H3, and Aurora B kinase inhibition led to a deficiency in RAD50-positive bridges. Based on these observations, we propose that RAD50 is a crucial factor for the stabilization and shielding of chromatin bridges. Our study provides evidence for a hitherto unknown role of RAD50 in abnormal cytokinesis.

42 CFR Appendix to Subpart B of... - Required Consent Form

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 1 2010-10-01 2010-10-01 false Required Consent Form Appendix to Subpart B of Part 50 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS POLICIES OF GENERAL APPLICABILITY Sterilization of Persons in Federally Assisted Family Planning Projects Pt. 50, Subpt. B, App. Appendix to Subpart B of Part 50...

42 CFR Appendix to Subpart B of... - Required Consent Form

Code of Federal Regulations, 2012 CFR

2012-10-01

... 42 Public Health 1 2012-10-01 2012-10-01 false Required Consent Form Appendix to Subpart B of Part 50 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS POLICIES OF GENERAL APPLICABILITY Sterilization of Persons in Federally Assisted Family Planning Projects Pt. 50, Subpt. B, App. Appendix to Subpart B of Part 50...

42 CFR Appendix to Subpart B of... - Required Consent Form

Code of Federal Regulations, 2014 CFR

2014-10-01

... 42 Public Health 1 2014-10-01 2014-10-01 false Required Consent Form Appendix to Subpart B of Part 50 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS POLICIES OF GENERAL APPLICABILITY Sterilization of Persons in Federally Assisted Family Planning Projects Pt. 50, Subpt. B, App. Appendix to Subpart B of Part 50...

42 CFR Appendix to Subpart B of... - Required Consent Form

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 1 2011-10-01 2011-10-01 false Required Consent Form Appendix to Subpart B of Part 50 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS POLICIES OF GENERAL APPLICABILITY Sterilization of Persons in Federally Assisted Family Planning Projects Pt. 50, Subpt. B, App. Appendix to Subpart B of Part 50...

42 CFR Appendix to Subpart B of... - Required Consent Form

Code of Federal Regulations, 2013 CFR

2013-10-01

... 42 Public Health 1 2013-10-01 2013-10-01 false Required Consent Form Appendix to Subpart B of Part 50 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES GRANTS POLICIES OF GENERAL APPLICABILITY Sterilization of Persons in Federally Assisted Family Planning Projects Pt. 50, Subpt. B, App. Appendix to Subpart B of Part 50...

The reference strain Aeromonas hydrophicla CIP 57.50 should be reclassified as Aeromonas salmonicida CIP 57.50.

PubMed

Miñana-Galbis, David; Farfàn, Maribel; Lorén, J Gaspar; Fusté, M Carmen

2010-03-01

The use of reference strains is a critical element for the quality control of different assays, from the development of molecular methods to the evaluation of antimicrobial activities. Most of the strains used in these assays are not type strains and some of them are cited erroneously because of subsequent reclassifications and descriptions of novel species. In this study, we propose that the reference strain Aeromonas hydrophila CIP 57.50 be reclassified as Aeromonas salmonicida CIP 57.50 based on phenotypic characterization and sequence analyses of the cpn60, dnaJ, gyrB and rpoD genes.

50 CFR 296.10 - Agency review.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Agency review. 296.10 Section 296.10..., DEPARTMENT OF COMMERCE CONTINENTAL SHELF FISHERMEN'S CONTINGENCY FUND § 296.10 Agency review. (a) Within 30..., NMFS, or his designee, for a review of the initial determination. (b) The petitioner may submit written...

50 CFR 665.605 - Gear restrictions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Gear restrictions. 665.605 Section 665.605... § 665.605 Gear restrictions. (a) Bottom trawls and bottom set gillnets. Fishing for PRIA bottomfish MUS with bottom trawls and bottom set gillnets is prohibited. (b) Possession of gear. Possession of a...

50 CFR 660.406 - Exempted fishing.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Exempted fishing. 660.406 Section 660.406... Exempted fishing. (a) NMFS may allow such exempted fishing in the fishery management area as may be... accustomed fishing grounds in the fishery management area. (b) NMFS will not allow any exempted fishery...

50 CFR 660.406 - Exempted fishing.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Exempted fishing. 660.406 Section 660.406... Exempted fishing. (a) NMFS may allow such exempted fishing in the fishery management area as may be... accustomed fishing grounds in the fishery management area. (b) NMFS will not allow any exempted fishery...

50 CFR 600.625 - Secretary's decision.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 10 2011-10-01 2011-10-01 false Secretary's decision. 600.625 Section 600... Section 306(b) § 600.625 Secretary's decision. (a) The Secretary will, on the basis of the hearing, record... for Federal preemption are determined to exist, the Secretary will notify in writing the Attorney...

50 CFR 600.625 - Secretary's decision.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 12 2012-10-01 2012-10-01 false Secretary's decision. 600.625 Section 600... Section 306(b) § 600.625 Secretary's decision. (a) The Secretary will, on the basis of the hearing, record... for Federal preemption are determined to exist, the Secretary will notify in writing the Attorney...

50 CFR 600.625 - Secretary's decision.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Secretary's decision. 600.625 Section 600... Section 306(b) § 600.625 Secretary's decision. (a) The Secretary will, on the basis of the hearing, record... for Federal preemption are determined to exist, the Secretary will notify in writing the Attorney...

B-52 Testing F-111 Parachute

NASA Technical Reports Server (NTRS)

1988-01-01

A mock-up of an F-111 cockpit section drops out of the bomb bay of NASA's B-52 mothership on a test flight of a new parachute system for the F-111 'Aardvark' bomber. The F-111's ejection system separated the entire cockpit from the rest of the aircraft, and a large parachute was then deployed to lower the cockpit section to the ground. NASA B-52, Tail Number 008, is an air launch carrier aircraft, 'mothership,' as well as a research aircraft platform that has been used on a variety of research projects. The aircraft, a 'B' model built in 1952 and first flown on June 11, 1955, is the oldest B-52 in flying status and has been used on some of the most significant research projects in aerospace history. Some of the significant projects supported by B-52 008 include the X-15, the lifting bodies, HiMAT (highly maneuverable aircraft technology), Pegasus, validation of parachute systems developed for the space shuttle program (solid-rocket-booster recovery system and the orbiter drag chute system), and the X-38. The B-52 served as the launch vehicle on 106 X-15 flights and flew a total of 159 captive-carry and launch missions in support of that program from June 1959 to October 1968. Information gained from the highly successful X-15 program contributed to the Mercury, Gemini, and Apollo human spaceflight programs as well as space shuttle development. Between 1966 and 1975, the B-52 served as the launch aircraft for 127 of the 144 wingless lifting body flights. In the 1970s and 1980s, the B-52 was the launch aircraft for several aircraft at what is now the Dryden Flight Research Center, Edwards, California, to study spin-stall, high-angle-of attack, and maneuvering characteristics. These included the 3/8-scale F-15/spin research vehicle (SRV), the HiMAT (Highly Maneuverable Aircraft Technology) research vehicle, and the DAST (drones for aerodynamic and structural testing). The aircraft supported the development of parachute recovery systems used to recover the space

The Madagascar hissing cockroach as a novel surrogate host for Burkholderia pseudomallei, B. mallei and B. thailandensis.

PubMed

Fisher, Nathan A; Ribot, Wilson J; Applefeld, Willard; DeShazer, David

2012-06-22

Burkholderia pseudomallei and Burkholderia mallei are gram-negative pathogens responsible for the diseases melioidosis and glanders, respectively. Both species cause disease in humans and animals and have been designated as category B select agents by the Centers for Disease Control and Prevention (CDC). Burkholderia thailandensis is a closely related bacterium that is generally considered avirulent for humans. While it can cause disease in rodents, the B. thailandensis 50% lethal dose (LD50) is typically ≥ 104-fold higher than the B. pseudomallei and B. mallei LD50 in mammalian models of infection. Here we describe an alternative to mammalian hosts in the study of virulence and host-pathogen interactions of these Burkholderia species. Madagascar hissing cockroaches (MH cockroaches) possess a number of qualities that make them desirable for use as a surrogate host, including ease of breeding, ease of handling, a competent innate immune system, and the ability to survive at 37°C. MH cockroaches were highly susceptible to infection with B. pseudomallei, B. mallei and B. thailandensis and the LD50 was <10 colony-forming units (cfu) for all three species. In comparison, the LD50 for Escherichia coli in MH cockroaches was >105 cfu. B. pseudomallei, B. mallei, and B. thailandensis cluster 1 type VI secretion system (T6SS-1) mutants were all attenuated in MH cockroaches, which is consistent with previous virulence studies conducted in rodents. B. pseudomallei mutants deficient in the other five T6SS gene clusters, T6SS-2 through T6SS-6, were virulent in both MH cockroaches and hamsters. Hemocytes obtained from MH cockroaches infected with B. pseudomallei harbored numerous intracellular bacteria, suggesting that this facultative intracellular pathogen can survive and replicate inside of MH cockroach phagocytic cells. The hemolymph extracted from these MH cockroaches also contained multinuclear giant cells (MNGCs) with intracellular B. pseudomallei, which indicates

The Army Air Forces in World War II. Volume 3. Europe: Argument to V-E Day, January 1944 to May 1945

DTIC Science & Technology

1983-01-01

ters, dispatching 3 2 8 heavy bombers and I 6 groups of fighters to drop more than 1,000 tons on the Troyes , Reims, Brussels, LiCge, Sarre...American bombers, nine of which were shot down on this occasion. On 3 0 May the Eighth attacked Troyes , Reims, and Brussels, and on 4 June it bombed...concentrated on forcing Seine crossings to the south where it passed the river barrier at Melun and Fontainebleau on the 24th an’d a t Troyes a day

Regulation of Mitochondria Function by TRAF3 in B Lymphocytes and B Cell Malignancies

DTIC Science & Technology

2014-08-01

PARP1, PHB2 4 Background B cell neoplasms account for over 90% of lymphoid tumors worldwide, and comprise >50% of blood cancers. Despite recent... cells examined include common lymphoid progenitor, pre-pro-B, pro-B, pre-B, newly-formed B, and transitional (T1, T2 and T3) B cells . The data in...factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs. Immunity 2007, 27:253-267. 13. Moore CR, Liu Y, Shao CS, Covey LR

40 CFR Table 1b to Subpart Ec of... - Emissions Limits for Small, Medium, and Large HMIWI at Affected Facilities as Defined in § 60.50c...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Waste Incinerators for Which Construction is Commenced After June 20, 1996 Pt. 60, Subpt. Ec, Table 1B... Facilities as Defined in § 60.50c(a)(3) and (4) Pollutant Units (7 percent oxygen, dry basis) Emissions... matter Milligrams per dry standard cubic meter (grains per dry standard cubic foot) 66 (0.029) 22 (0.0095...

41 CFR 50-204.6 - Medical services and first aid.

Code of Federal Regulations, 2012 CFR

2012-07-01

... plant health. (b) In the absence of an infirmary, clinic or hospital in near proximity to the work place... 41 Public Contracts and Property Management 1 2012-07-01 2009-07-01 true Medical services and first aid. 50-204.6 Section 50-204.6 Public Contracts and Property Management Other Provisions Relating...

41 CFR 50-204.6 - Medical services and first aid.

Code of Federal Regulations, 2011 CFR

2011-07-01

... plant health. (b) In the absence of an infirmary, clinic or hospital in near proximity to the work place... 41 Public Contracts and Property Management 1 2011-07-01 2009-07-01 true Medical services and first aid. 50-204.6 Section 50-204.6 Public Contracts and Property Management Other Provisions Relating...

41 CFR 50-204.6 - Medical services and first aid.

Code of Federal Regulations, 2013 CFR

2013-07-01

... plant health. (b) In the absence of an infirmary, clinic or hospital in near proximity to the work place... 41 Public Contracts and Property Management 1 2013-07-01 2013-07-01 false Medical services and first aid. 50-204.6 Section 50-204.6 Public Contracts and Property Management Other Provisions Relating...

41 CFR 50-204.6 - Medical services and first aid.

Code of Federal Regulations, 2014 CFR

2014-07-01

... plant health. (b) In the absence of an infirmary, clinic or hospital in near proximity to the work place... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Medical services and first aid. 50-204.6 Section 50-204.6 Public Contracts and Property Management Other Provisions Relating...

22 CFR 50.50 - Renunciation of nationality.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Renunciation of nationality. 50.50 Section 50.50 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS NATIONALITY PROCEDURES Loss of Nationality § 50.50 Renunciation of nationality. (a) A person desiring to renounce U.S. nationality under...

22 CFR 50.50 - Renunciation of nationality.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Renunciation of nationality. 50.50 Section 50.50 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS NATIONALITY PROCEDURES Loss of Nationality § 50.50 Renunciation of nationality. (a) A person desiring to renounce U.S. nationality under...

22 CFR 50.50 - Renunciation of nationality.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Renunciation of nationality. 50.50 Section 50.50 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS NATIONALITY PROCEDURES Loss of Nationality § 50.50 Renunciation of nationality. (a) A person desiring to renounce U.S. nationality under...

22 CFR 50.50 - Renunciation of nationality.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Renunciation of nationality. 50.50 Section 50.50 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS NATIONALITY PROCEDURES Loss of Nationality § 50.50 Renunciation of nationality. (a) A person desiring to renounce U.S. nationality under...

22 CFR 50.50 - Renunciation of nationality.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Renunciation of nationality. 50.50 Section 50.50 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS NATIONALITY PROCEDURES Loss of Nationality § 50.50 Renunciation of nationality. (a) A person desiring to renounce U.S. nationality under...

11 CFR 9008.50 - Scope and definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Representing a Convention City § 9008.50 Scope and definitions. (a) Scope. This subpart B governs registration and reporting by host committees and municipal funds representing convention cities. Unsuccessful efforts to attract a convention need not be reported by any city, committee or other organization. Subpart...

31 CFR 50.74 - Collecting the Surcharge.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Section 50.74 Money and Finance: Treasury Office of the Secretary of the Treasury TERRORISM RISK INSURANCE... Federal Terrorism Policy Surcharge from policyholders as required by Treasury. (b) Policies subject to the Federal Terrorism Policy Surcharge are those for which direct written premium is reported on commercial...

46 CFR 42.07-50 - Penalties for violations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... BY SEA Control, Enforcement, and Rights of Appeal § 42.07-50 Penalties for violations. (a) The... these laws. (b) The master and/or owner of a vessel that is operated, navigated, or used in violation of...

46 CFR 42.07-50 - Penalties for violations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... BY SEA Control, Enforcement, and Rights of Appeal § 42.07-50 Penalties for violations. (a) The... these laws. (b) The master and/or owner of a vessel that is operated, navigated, or used in violation of...

46 CFR 42.07-50 - Penalties for violations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... BY SEA Control, Enforcement, and Rights of Appeal § 42.07-50 Penalties for violations. (a) The... these laws. (b) The master and/or owner of a vessel that is operated, navigated, or used in violation of...

46 CFR 42.07-50 - Penalties for violations.

Code of Federal Regulations, 2013 CFR

2013-10-01

... BY SEA Control, Enforcement, and Rights of Appeal § 42.07-50 Penalties for violations. (a) The... these laws. (b) The master and/or owner of a vessel that is operated, navigated, or used in violation of...

46 CFR 42.07-50 - Penalties for violations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... BY SEA Control, Enforcement, and Rights of Appeal § 42.07-50 Penalties for violations. (a) The... these laws. (b) The master and/or owner of a vessel that is operated, navigated, or used in violation of...

Aircraft Fleet on the Tarmac at the Lewis Flight Propulsion Laboratory

NASA Image and Video Library

1946-04-21

This fleet of military aircraft was used in the 1940s for research at the National Advisory Committee for Aeronautics (NACA) Lewis Flight Propulsion Laboratory in Cleveland, Ohio. The NACA Lewis flight research program was established in March 1943 to augment the lab’s wartime research efforts. NACA Lewis possessed a host of wind tunnels, test stands, and other ground facilities designed to replicate flight conditions, but actual flight tests remained an integral research tool. The military loaned NACA Lewis 15 different aircraft during World War II and six others in the six months following the end of hostilities. During the war these aircraft supported three main efforts: the improved performance of reciprocating engines, better fuel additives and mixtures, and deicing systems. The wartime researchers used the types of aircraft which the studies were intended to improve. After the war the research aircraft served as test beds to investigate engines or systems that often had little to do with the research aircraft. During the war, NACA Lewis’ three pilots were supported by 16 flight engineers, 36 mechanics, and 10 instrumentation specialists. The visible aircraft, from left to right, are a Boeing B-29 Superfortress, a Martin B-26A Marauder, two Consolidated B-24 Liberators, a Cessna UC-78 Bobcat, and a Northrop P-61 Black Widow. Partially obscured are a North American P-51 Mustang, a Bell P-63 King Cobra, a North American AT-6 Texan, and a Lockheed RA-29 Hudson.

Some comparisons of US and USSR aircraft design developments

NASA Technical Reports Server (NTRS)

Spearman, M. L.

1985-01-01

A review is given of the design and development of some US and USSR aircraft. The emphasis is on the historical development of large aircraft-civil and military transports and bombers. Design trends are somewhat similar for the two countries and indications are that some fundamental characteristics are dictated more by ideological differences rather than technological differences. A brief description is given in a more or less chronological order of the major bomber aircraft, major civil and military transport aircraft, and the development of the air transport systems.

46 CFR 56.50-45 - Circulating pumps.

Code of Federal Regulations, 2010 CFR

2010-10-01

... APPURTENANCES Design Requirements Pertaining to Specific Systems § 56.50-45 Circulating pumps. (a) A main circulating pump and emergency means for circulating water through the main condenser shall be provided. The... circulating pump and the condenser. (b) Independent sea suctions shall be provided for the main circulating...

50 CFR 665.814 - Protected species workshop.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false Protected species workshop. 665.814... Pacific Pelagic Fisheries § 665.814 Protected species workshop. (a) Each year, both the owner and the... turtles, seabirds and other protected species. (b) A protected species workshop certificate will be issued...

50 CFR 665.814 - Protected species workshop.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Protected species workshop. 665.814... Pacific Pelagic Fisheries § 665.814 Protected species workshop. (a) Each year, both the owner and the... turtles, seabirds and other protected species. (b) A protected species workshop certificate will be issued...

50 CFR 665.814 - Protected species workshop.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Protected species workshop. 665.814... Pacific Pelagic Fisheries § 665.814 Protected species workshop. (a) Each year, both the owner and the... turtles, seabirds and other protected species. (b) A protected species workshop certificate will be issued...

50 CFR 665.814 - Protected species workshop.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Protected species workshop. 665.814... Pacific Pelagic Fisheries § 665.814 Protected species workshop. (a) Each year, both the owner and the... turtles, seabirds and other protected species. (b) A protected species workshop certificate will be issued...

50 CFR 665.814 - Protected species workshop.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Protected species workshop. 665.814... Pacific Pelagic Fisheries § 665.814 Protected species workshop. (a) Each year, both the owner and the... turtles, seabirds and other protected species. (b) A protected species workshop certificate will be issued...

Control Systems

NASA Technical Reports Server (NTRS)

1984-01-01

Boeing Commercial Airplane Company's Flight Control Department engineers relied on Langley developed software package known as ORACLS to develop an advanced control synthesis package for both continuous and discrete control system. Package was used by Boeing for computerized analysis of new system designs. Resulting applications include a multiple input/output control system for the terrain-following navigation equipment of the Air Forces B-1 Bomber, and another for controlling in flight changes of wing camber on an experimental airplane. ORACLS is one of 1,300 computer programs available from COSMIC.

Recent US and Chinese Antisatellite Activities

DTIC Science & Technology

2009-01-01

late 1950s, high­ lighted by the launch of a Bold Orion missile from a B-47 bomber. Pres. Gerald R . Ford’s directive of 1975 allowed explo­ ration of...story_generic.jsp?channel = awst &id=news/aw021808p2.xml&headline=U.S.%20To%20Shoot%20Down%20Satellite (accessed 30 October 2008). The Air Force launched NRO...Michael R . Mantz, The New Sword: A Theory of Space Combat Power, research report no. AU-ARI­ 94-6 (Maxwell AFB, AL: Air University Press, May 1995), 99

10 CFR 50.71 - Maintenance of records, making of reports.

Code of Federal Regulations, 2010 CFR

2010-01-01

... must be submitted in accordance with § 50.4 or 10 CFR 52.3, as applicable. (b) With respect to any..., shall update periodically, as provided in paragraphs (e) (3) and (4) of this section, the final safety... provisions of § 50.59 but not previously submitted to the Commission. (3)(i) A revision of the original FSAR...

26 CFR 1.50A-2 - Carryback and carryover of unused credit.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Section 1.50A-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY INCOME TAX INCOME TAXES Rules for Computing Credit for Expenses of Work Incentive Programs § 1.50A-2 Carryback and... limitation based on amount of tax for such taxable year (as determined under paragraph (b) of § 1.50A-1...

50 CFR 17.7 - Raptor exemption.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 2 2010-10-01 2010-10-01 false Raptor exemption. 17.7 Section 17.7....7 Raptor exemption. (a) The prohibitions found in §§ 17.21 and 17.31 do not apply to any raptor [a... permittee's possession on November 10, 1978, or as the progeny of such a raptor. (b) This section does not...

50 CFR 622.37 - Size limits.

Code of Federal Regulations, 2010 CFR

2010-10-01

... fish—(1) Snapper. (i) Lane snapper—8 inches (20.3 cm), TL. (ii) Vermilion snapper—10 inches (25.4 cm... person subject to the bag limit specified in § 622.39(b)(1)(ii)—20 inches (50.8 cm), TL. (3) Other Gulf... Atlantic snapper-grouper—(1) Snapper. (i) Lane snapper—8 inches (20.3 cm), TL. (ii) Vermilion snapper—12...

50 CFR 622.37 - Size limits.

Code of Federal Regulations, 2011 CFR

2011-10-01

... fish—(1) Snapper. (i) Lane snapper—8 inches (20.3 cm), TL. (ii) Vermilion snapper—10 inches (25.4 cm... person subject to the bag limit specified in § 622.39(b)(1)(ii)—20 inches (50.8 cm), TL. (3) Other Gulf... Atlantic snapper-grouper—(1) Snapper. (i) Lane snapper—8 inches (20.3 cm), TL. (ii) Vermilion snapper—12...

50 CFR 100.12 - Local advisory committees.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Local advisory committees. 100.12 Section... Structure § 100.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory... in § 100.11. (b) Local Federal Advisory Committees, if established by the Board, shall operate in...

50 CFR 100.12 - Local advisory committees.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false Local advisory committees. 100.12 Section... Structure § 100.12 Local advisory committees. (a) The Board shall establish such local Federal Advisory... in § 100.11. (b) Local Federal Advisory Committees, if established by the Board, shall operate in...

10 CFR 50.82 - Termination of license.

Code of Federal Regulations, 2011 CFR

2011-01-01

... to the NRC, consistent with the requirements of § 50.4(b)(8); (ii) Once fuel has been permanently... fuel from the reactor vessel, or when a final legally effective order to permanently cease operations... emplacement or retention of fuel into the reactor vessel. (3) Decommissioning will be completed within 60...

46 CFR 151.50-32 - Ammonia, anhydrous.

Code of Federal Regulations, 2014 CFR

2014-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-32 Ammonia, anhydrous. (a) The anhydrous ammonia tanks may be installed in the bulk liquid cargo tanks provided the liquid surrounding the...) Noncorrosive in the liquid and vapor phase to the ammonia tanks and piping. (b) Copper, copper alloys, and...

46 CFR 151.50-32 - Ammonia, anhydrous.

Code of Federal Regulations, 2011 CFR

2011-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-32 Ammonia, anhydrous. (a) The anhydrous ammonia tanks may be installed in the bulk liquid cargo tanks provided the liquid surrounding the...) Noncorrosive in the liquid and vapor phase to the ammonia tanks and piping. (b) Copper, copper alloys, and...

46 CFR 151.50-32 - Ammonia, anhydrous.

Code of Federal Regulations, 2010 CFR

2010-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-32 Ammonia, anhydrous. (a) The anhydrous ammonia tanks may be installed in the bulk liquid cargo tanks provided the liquid surrounding the...) Noncorrosive in the liquid and vapor phase to the ammonia tanks and piping. (b) Copper, copper alloys, and...

46 CFR 151.50-55 - Sulfur (molten).

Code of Federal Regulations, 2013 CFR

2013-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-55 Sulfur (molten). (a... below one-half of its lower explosive limit throughout the cargo tank vapor space for all conditions of... depositing of sulfur within the system. (b) Void spaces: (1) Openings to void spaces adjacent to cargo tanks...

46 CFR 151.50-55 - Sulfur (molten).

Code of Federal Regulations, 2014 CFR

2014-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-55 Sulfur (molten). (a... below one-half of its lower explosive limit throughout the cargo tank vapor space for all conditions of... depositing of sulfur within the system. (b) Void spaces: (1) Openings to void spaces adjacent to cargo tanks...

46 CFR 151.50-55 - Sulfur (molten).

Code of Federal Regulations, 2012 CFR

2012-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-55 Sulfur (molten). (a... below one-half of its lower explosive limit throughout the cargo tank vapor space for all conditions of... depositing of sulfur within the system. (b) Void spaces: (1) Openings to void spaces adjacent to cargo tanks...

46 CFR 151.50-32 - Ammonia, anhydrous.

Code of Federal Regulations, 2013 CFR

2013-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-32 Ammonia, anhydrous. (a) The anhydrous ammonia tanks may be installed in the bulk liquid cargo tanks provided the liquid surrounding the...) Noncorrosive in the liquid and vapor phase to the ammonia tanks and piping. (b) Copper, copper alloys, and...

46 CFR 151.50-32 - Ammonia, anhydrous.

Code of Federal Regulations, 2012 CFR

2012-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-32 Ammonia, anhydrous. (a) The anhydrous ammonia tanks may be installed in the bulk liquid cargo tanks provided the liquid surrounding the...) Noncorrosive in the liquid and vapor phase to the ammonia tanks and piping. (b) Copper, copper alloys, and...

46 CFR 151.50-55 - Sulfur (molten).

Code of Federal Regulations, 2011 CFR

2011-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-55 Sulfur (molten). (a... below one-half of its lower explosive limit throughout the cargo tank vapor space for all conditions of... depositing of sulfur within the system. (b) Void spaces: (1) Openings to void spaces adjacent to cargo tanks...

46 CFR 151.50-55 - Sulfur (molten).

Code of Federal Regulations, 2010 CFR

2010-10-01

... BULK LIQUID HAZARDOUS MATERIAL CARGOES Special Requirements § 151.50-55 Sulfur (molten). (a... below one-half of its lower explosive limit throughout the cargo tank vapor space for all conditions of... depositing of sulfur within the system. (b) Void spaces: (1) Openings to void spaces adjacent to cargo tanks...

33 CFR 110.50d - Mystic Harbor, Noank, Conn.

Code of Federal Regulations, 2010 CFR

2010-07-01

... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.50d Mystic Harbor, Noank, Conn. (a) The area... to the point of beginning. (b) The following requirements shall govern this special anchorage area...

33 CFR 110.50d - Mystic Harbor, Noank, Conn.

Code of Federal Regulations, 2012 CFR

2012-07-01

... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.50d Mystic Harbor, Noank, Conn. (a) The area... to the point of beginning. (b) The following requirements shall govern this special anchorage area...

33 CFR 110.50d - Mystic Harbor, Noank, Conn.

Code of Federal Regulations, 2014 CFR

2014-07-01

... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.50d Mystic Harbor, Noank, Conn. (a) The area... to the point of beginning. (b) The following requirements shall govern this special anchorage area...

33 CFR 110.50d - Mystic Harbor, Noank, Conn.

Code of Federal Regulations, 2011 CFR

2011-07-01

... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.50d Mystic Harbor, Noank, Conn. (a) The area... to the point of beginning. (b) The following requirements shall govern this special anchorage area...

33 CFR 110.50d - Mystic Harbor, Noank, Conn.

Code of Federal Regulations, 2013 CFR

2013-07-01

... ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.50d Mystic Harbor, Noank, Conn. (a) The area... to the point of beginning. (b) The following requirements shall govern this special anchorage area...

Pre-S2 Start Codon Mutation of Hepatitis B Virus Subgenotype B3 Effects on NF-κB Expression and Activation in Huh7 Cell Lines.

PubMed

Siburian, Marlinang Diarta; Suriapranata, Ivet Marita; Wanandi, Septelia Inawati

2018-03-19

A cross-sectional study on hepatitis B patients in Indonesia showed association of pre-S2 start codon mutation (M120 V) with cirrhosis and hepatocellular carcinoma (HCC), which was dissimilar from studies from other populations where pre-S2 deletion mutation was more prevalent. Different mutation patterns were attributed to different hepatitis B virus (HBV) subgenotypes in each population study. HBV surface proteins are reported to induce the activation of NF-κB, a transcriptional factor known to play an important role in the development of liver disease. This study aimed to see the effects of HBs variants in HBV subgenotype B3 on the expression and activation of NF-κB as one of the mechanisms in inducing advanced liver disease. HBV subgenotypes B3, each carrying wild-type (wt) HBs, M120 V, and pre-S2 deletion mutation were isolated from three HCC patients. HBs genes were amplified and cloned into pcDNA3.1 and were transfected using Lipofectamine into a Huh7 cell line. NF-κB activation was measured through IκB-α expression, which is regulated by NF-κB. RNA expressions for HBs, IκB-α, and NF-κB subunit (p50) were evaluated using real-time PCR. M120 V mutant had a significantly higher mRNA level compared with wt and pre-S2 deletion mutant; however, there were no significant differences in HBs protein expressions. The transcription level of p50 was higher in M120 V mutation compared with HBs wild-type and pre-S2 deletion mutant. NF-κB activation was higher in HBs wild-type compared with the two mutant variants. Pre-S2 mutations had no effect on the increment of NF-κB activation. However, M120 V mutation may utilize a different pathway in liver disease progression that involves high expression of NF-κB subunit, p50.

50 years of Dutch immunology--founders, institutions, highlights.

PubMed

Gmelig-Meyling, Frits H J; Meyaard, Linde; Mebius, Reina E

2014-12-01

At the occasion of the 50th anniversary of the Dutch Society for Immunology (DSI, de Nederlandse Vereniging voor Immunologie), this contribution deals with some highlights of 50 years of Immunology in the Netherlands. It narrates about the founders and first board members of the DSI, their institutes, progeny and patrimony, describes major centers of immunological activities, mentions key persons in the field, and touches upon some events dear to the Society and its members. Copyright © 2014 Elsevier B.V. All rights reserved.

21 CFR 107.50 - Terms and conditions.

Code of Federal Regulations, 2011 CFR

2011-04-01

... HUMAN CONSUMPTION INFANT FORMULA Exempt Infant Formulas § 107.50 Terms and conditions. (a) Terms and...) of the act infant formulas that are represented and labeled for use by an infant who has an inborn... establish the terms and conditions that a manufacturer must meet with respect to such infant formulas. (b...

50 CFR 82.8 - Prosecution of work.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 8 2011-10-01 2011-10-01 false Prosecution of work. 82.8 Section 82.8... (MARINE MAMMAL PROTECTION ACT OF 1972) Administration § 82.8 Prosecution of work. (a) The grantee shall... by the Secretary that satisfactory progress has not been maintained. (b) All work shall be performed...

50 CFR 622.186 - Landing fish intact.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Landing fish intact. 622.186 Section 622...-Grouper Fishery of the South Atlantic Region § 622.186 Landing fish intact. (a) South Atlantic snapper... specified in paragraph (b) of this section. Such fish may be eviscerated, gilled, and scaled, but must...

50 CFR 622.186 - Landing fish intact.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Landing fish intact. 622.186 Section 622...-Grouper Fishery of the South Atlantic Region § 622.186 Landing fish intact. (a) South Atlantic snapper... specified in paragraph (b) of this section. Such fish may be eviscerated, gilled, and scaled, but must...

50 CFR 622.37 - Size limits.

Code of Federal Regulations, 2012 CFR

2012-10-01

... fish—(1) Snapper. (i) Lane snapper—8 inches (20.3 cm), TL. (ii) Vermilion snapper—10 inches (25.4 cm... specified in § 622.39(b)(1)(ii)—20 inches (50.8 cm), TL. (v) Gag—22 inches (55.9 cm), TL. (3) Other Gulf... Atlantic snapper-grouper—(1) Snapper. (i) Lane snapper—8 inches (20.3 cm), TL. (ii) Vermilion snapper—12...

46 CFR 4.06-50 - Specimen analysis and follow-up procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... to develop all relevant information and to produce a complete analysis report. (b) Reports shall be... 46 Shipping 1 2011-10-01 2011-10-01 false Specimen analysis and follow-up procedures. 4.06-50... Involving Vessels in Commercial Service § 4.06-50 Specimen analysis and follow-up procedures. (a) Each...

46 CFR 4.06-50 - Specimen analysis and follow-up procedures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... to develop all relevant information and to produce a complete analysis report. (b) Reports shall be... 46 Shipping 1 2012-10-01 2012-10-01 false Specimen analysis and follow-up procedures. 4.06-50... Involving Vessels in Commercial Service § 4.06-50 Specimen analysis and follow-up procedures. (a) Each...

41 CFR 105-50.202-3 - Training.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false Training. 105-50.202-3....202-3 Training. (a) This training consists of the type which GSA is authorized by law to conduct for Federal personnel and others or which is similar to such training. (b) Descriptions of the specific...

41 CFR 105-50.202-3 - Training.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Training. 105-50.202-3....202-3 Training. (a) This training consists of the type which GSA is authorized by law to conduct for Federal personnel and others or which is similar to such training. (b) Descriptions of the specific...

50 CFR 520.6 - Extensions of time.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Extensions of time. 520.6 Section 520.6 Wildlife and Fisheries MARINE MAMMAL COMMISSION PUBLIC AVAILABILITY OF AGENCY MATERIALS § 520.6 Extensions of time. (a) Whenever unusual circumstances exist, as set forth in § 520.6(b), the times within which...

50 CFR 635.50 - Basis and purpose.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Basis and purpose. 635.50 Section 635.50 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE ATLANTIC HIGHLY MIGRATORY SPECIES International Port Inspection § 635.50 Basis and...

50 CFR 635.50 - Basis and purpose.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 12 2013-10-01 2013-10-01 false Basis and purpose. 635.50 Section 635.50 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE ATLANTIC HIGHLY MIGRATORY SPECIES International Port Inspection § 635.50 Basis and...

50 CFR 12.36 - Donation or loan.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Donation or loan. 12.36 Section 12.36... SEIZURE AND FORFEITURE PROCEDURES Disposal of Forfeited or Abandoned Property § 12.36 Donation or loan. (a... and security for the item. (b) Any donation or loan may be made only after execution of a transfer...

50 CFR 12.36 - Donation or loan.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 1 2012-10-01 2012-10-01 false Donation or loan. 12.36 Section 12.36... SEIZURE AND FORFEITURE PROCEDURES Disposal of Forfeited or Abandoned Property § 12.36 Donation or loan. (a... and security for the item. (b) Any donation or loan may be made only after execution of a transfer...

50 CFR 12.36 - Donation or loan.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 1 2014-10-01 2014-10-01 false Donation or loan. 12.36 Section 12.36... SEIZURE AND FORFEITURE PROCEDURES Disposal of Forfeited or Abandoned Property § 12.36 Donation or loan. (a... and security for the item. (b) Any donation or loan may be made only after execution of a transfer...

50 CFR 12.36 - Donation or loan.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 1 2013-10-01 2013-10-01 false Donation or loan. 12.36 Section 12.36... SEIZURE AND FORFEITURE PROCEDURES Disposal of Forfeited or Abandoned Property § 12.36 Donation or loan. (a... and security for the item. (b) Any donation or loan may be made only after execution of a transfer...

50 CFR 622.30 - Required fishing gear.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 12 2014-10-01 2014-10-01 false Required fishing gear. 622.30 Section 622... Resources of the Gulf of Mexico § 622.30 Required fishing gear. For a person on board a vessel to fish for... steel circle hooks are required when fishing with natural baits. (b) Dehooking device. At least one...

50 CFR 401.6 - Prosecution of work.

Code of Federal Regulations, 2010 CFR

2010-10-01

... maintained. The Secretary shall have the right to inspect and review work at any time. (b) Research and... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Prosecution of work. 401.6 Section 401.6..., DEVELOPMENT AND ENHANCEMENT § 401.6 Prosecution of work. (a) Project work shall be carried through to a state...

Sporicidal activity of a new low-temperature sterilization technology: the Sterrad 50 sterilizer.

PubMed

Rutala, W A; Gergen, M F; Weber, D J

1999-07-01

This study was undertaken to evaluate the efficacy of a new low-temperature sterilization system that recently has been cleared by the Food and Drug Administration, the Sterrad 50. Flat stainless steel carriers were inoculated with approximately 10(6) Bacillus stearothermophilus spores. These carriers were placed aseptically in the middle of 40-cm-long stainless steel-lumened test units of varying diameters (1 mm, 2 mm, and 3 mm). After inoculation, the test units were processed in the Sterrad 50. After sterilization, the carriers were assayed for growth of the B. stearothermophilus spores. Our data demonstrated that the Sterrad 50 was highly effective in killing the B. stearothermophilus spores (no positive carriers with 30 tests of each lumen-diameter test unit). The Sterrad 50 is likely to be clinically useful for the sterilization of heat-sensitive medical equipment.

Statistical strategies for averaging EC50 from multiple dose-response experiments.

PubMed

Jiang, Xiaoqi; Kopp-Schneider, Annette

2015-11-01

In most dose-response studies, repeated experiments are conducted to determine the EC50 value for a chemical, requiring averaging EC50 estimates from a series of experiments. Two statistical strategies, the mixed-effect modeling and the meta-analysis approach, can be applied to estimate average behavior of EC50 values over all experiments by considering the variabilities within and among experiments. We investigated these two strategies in two common cases of multiple dose-response experiments in (a) complete and explicit dose-response relationships are observed in all experiments and in (b) only in a subset of experiments. In case (a), the meta-analysis strategy is a simple and robust method to average EC50 estimates. In case (b), all experimental data sets can be first screened using the dose-response screening plot, which allows visualization and comparison of multiple dose-response experimental results. As long as more than three experiments provide information about complete dose-response relationships, the experiments that cover incomplete relationships can be excluded from the meta-analysis strategy of averaging EC50 estimates. If there are only two experiments containing complete dose-response information, the mixed-effects model approach is suggested. We subsequently provided a web application for non-statisticians to implement the proposed meta-analysis strategy of averaging EC50 estimates from multiple dose-response experiments.

The effects of upaB deletion and the double/triple deletion of upaB, aatA, and aatB genes on pathogenicity of avian pathogenic Escherichia coli.

PubMed

Zhu-Ge, Xiang-Kai; Pan, Zi-Hao; Tang, Fang; Mao, Xiang; Hu, Lin; Wang, Shao-Hui; Xu, Bin; Lu, Cheng-Ping; Fan, Hong-Jie; Dai, Jian-Jun

2015-12-01

Autotransporters (ATs) are associated with pathogenesis of Avian Pathogenic Escherichia coli (APEC). The molecular characterization of APEC ATs can provide insights about their relevance to APEC pathogenesis. Here, we characterized a conventional autotransporter UpaB in APEC DE205B genome. The upaB existed in 41.9 % of 236 APEC isolates and was predominantly associated with ECOR B2 and D. Our studies showed that UpaB mediates the DE205B adhesion in DF-1 cells, and enhances autoaggregation and biofilm formation of fimbria-negative E. coli AAEC189 (MG1655Δfim) in vitro. Deletion of upaB of DE205B attenuates the virulence in duck model and early colonization in the duck lungs during APEC systemic infection. Furthermore, double and triple deletion of upaB, aatA, and aatB genes cumulatively attenuated DE205B adhesion in DF-1 cells, accompanying with decreased 50 % lethal dose (LD50) in duck model and the early colonization in the duck lungs. However, DE205BΔupaB/ΔaatA/ΔaatB might "compensate" the influence of gene deletion by upregulating the expression of fimbrial adhesin genes yqiL, yadN, and vacuolating autotransporter vat during early colonization of APEC. Finally, we demonstrated that vaccination with recombinant UpaB, AatA, and AatB proteins conferred protection against colisepticemia caused by DE205B infection in duck model.

34 CFR 654.50 - How does an SEA disburse scholarship funds?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 3 2011-07-01 2011-07-01 false How does an SEA disburse scholarship funds? 654.50... Receive Scholarship Payments? § 654.50 How does an SEA disburse scholarship funds? (a) Except as provided in paragraph (b) of this section, the SEA shall disburse $1,500 for each year of study for a maximum...

34 CFR 654.50 - How does an SEA disburse scholarship funds?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false How does an SEA disburse scholarship funds? 654.50... Receive Scholarship Payments? § 654.50 How does an SEA disburse scholarship funds? (a) Except as provided in paragraph (b) of this section, the SEA shall disburse $1,500 for each year of study for a maximum...

34 CFR 654.50 - How does an SEA disburse scholarship funds?

Code of Federal Regulations, 2014 CFR

2014-07-01

... 34 Education 3 2014-07-01 2014-07-01 false How does an SEA disburse scholarship funds? 654.50... Receive Scholarship Payments? § 654.50 How does an SEA disburse scholarship funds? (a) Except as provided in paragraph (b) of this section, the SEA shall disburse $1,500 for each year of study for a maximum...

34 CFR 654.50 - How does an SEA disburse scholarship funds?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 3 2013-07-01 2013-07-01 false How does an SEA disburse scholarship funds? 654.50... Receive Scholarship Payments? § 654.50 How does an SEA disburse scholarship funds? (a) Except as provided in paragraph (b) of this section, the SEA shall disburse $1,500 for each year of study for a maximum...

34 CFR 654.50 - How does an SEA disburse scholarship funds?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 3 2012-07-01 2012-07-01 false How does an SEA disburse scholarship funds? 654.50... Receive Scholarship Payments? § 654.50 How does an SEA disburse scholarship funds? (a) Except as provided in paragraph (b) of this section, the SEA shall disburse $1,500 for each year of study for a maximum...

34 CFR 379.50 - What are the requirements for continuation funding?

Code of Federal Regulations, 2011 CFR

2011-07-01

... What Compliance Indicator Requirements Must a Grantee Meet To Receive Continuation Funding? § 379.50...; and (b) Meet the minimum performance levels on— (1) The two “primary” program compliance indicators... indicators identified in § 379.51(c) and described in § 379.53(b). (Authority: Section 611(f)(4) of the Act...

X-38 on B-52 Wing Pylon - View from Observation Window

NASA Technical Reports Server (NTRS)

1997-01-01

A unique, close-up view of the X-38 under the wing of NASA's B-52 mothership prior to launch of the lifting-body research vehicle. The photo was taken from the observation window of the B-52 bomber as it banked in flight. NASA B-52, Tail Number 008, is an air launch carrier aircraft, 'mothership,' as well as a research aircraft platform that has been used on a variety of research projects. The aircraft, a 'B' model built in 1952 and first flown on June 11, 1955, is the oldest B-52 in flying status and has been used on some of the most significant research projects in aerospace history. Some of the significant projects supported by B-52 008 include the X-15, the lifting bodies, HiMAT (highly maneuverable aircraft technology), Pegasus, validation of parachute systems developed for the space shuttle program (solid-rocket-booster recovery system and the orbiter drag chute system), and the X-38. The B-52 served as the launch vehicle on 106 X-15 flights and flew a total of 159 captive-carry and launch missions in support of that program from June 1959 to October 1968. Information gained from the highly successful X-15 program contributed to the Mercury, Gemini, and Apollo human spaceflight programs as well as space shuttle development. Between 1966 and 1975, the B-52 served as the launch aircraft for 127 of the 144 wingless lifting body flights. In the 1970s and 1980s, the B-52 was the launch aircraft for several aircraft at what is now the Dryden Flight Research Center, Edwards, California, to study spin-stall, high-angle-of attack, and maneuvering characteristics. These included the 3/8-scale F-15/spin research vehicle (SRV), the HiMAT (Highly Maneuverable Aircraft Technology) research vehicle, and the DAST (drones for aerodynamic and structural testing). The aircraft supported the development of parachute recovery systems used to recover the space shuttle solid rocket booster casings. It also supported eight orbiter (space shuttle) drag chute tests in 1990. In

Trichomonas vaginalis metalloproteinase TvMP50 is a monomeric Aminopeptidase P-like enzyme.

PubMed

Arreola, Rodrigo; Villalpando, José Luis; Puente-Rivera, Jonathan; Morales-Montor, Jorge; Rudiño-Piñera, Enrique; Alvarez-Sánchez, María Elizbeth

2018-06-23

Previously, metalloproteinase was isolated and identified from Trichomonas vaginalis, belonging to the aminopeptidase P-like metalloproteinase subfamily A/B, family M24 of clan MG, named TvMP50. The native and recombinant TvMP50 showed proteolytic activity, determined by gelatin zymogram, and a 50 kDa band, suggesting that TvMP50 is a monomeric active enzyme. This was an unexpected finding since other Xaa-Pro aminopeptidases/prolidases are active as a biological unit formed by dimers/tetramers. In this study, the evolutionary history of TvMP50 and the preliminary crystal structure of the recombinant enzyme determined at 3.4 Å resolution is reported. TvMP50 was shown to be a type of putative, eukaryotic, monomeric aminopeptidase P, and the crystallographic coordinates showed a monomer on a "pseudo-homodimer" array on the asymmetric unit that resembles the quaternary structure of the M24B dimeric family and suggests a homodimeric aminopeptidase P-like enzyme as a likely ancestor. Interestingly, TvMP50 had a modified N-terminal region compared with other Xaa-Pro aminopeptidases/prolidases with three-dimensional structures; however, the formation of the standard dimer is structurally unstable in aqueous solution, and a comparably reduced number of hydrogen bridges and lack of saline bridges were found between subunits A/B, which could explain why TvMP50 portrays monomeric functionality. Additionally, we found that the Parabasalia group contains two protein lineages with a "pita bread" fold; the ancestral monomeric group 1 was probably derived from an ancestral dimeric aminopeptidase P-type enzyme, and group 2 has a probable dimeric kind of ancestral eukaryotic prolidase lineage. The implications of such hypotheses are also presented.

Competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors, prenylated caged xanthones from Garcinia hanburyi and their inhibitory mechanism.

PubMed

Tan, Xue Fei; Uddin, Zia; Park, Chanin; Song, Yeong Hun; Son, Minky; Lee, Keun Woo; Park, Ki Hun

2017-04-15

Protein tyrosine phosphatase 1B (PTP1B) plays important role in diabetes, obesity and cancer. The methanol extract of the gum resin of Garcinia hanburyi (G. hanburyi) showed potent PTP1B inhibition at 10µg/ml. The active compounds were identified as prenylated caged xanthones (1-9) which inhibited PTP1B in dose-dependent manner. Carboxybutenyl group within caged motif (A ring) was found to play a critical role in enzyme inhibition such as 1-6 (IC 50 s=0.47-4.69µM), whereas compounds having hydroxymethylbutenyl 7 (IC 50 =70.25µM) and methylbutenyl 8 (IC 50 >200µM) showed less activity. The most potent inhibitor, gambogic acid 1 (IC 50 =0.47µM) showed 30-fold more potency than ursolic acid (IC 50 =15.5µM), a positive control. In kinetic study, all isolated xanthones behaved as competitive inhibitors which were fully demonstrated with K m , V max and K ik /K iv ratio. It was also proved that inhibitor 1 operated under the enzyme isomerization model having k 5 =0.0751µM - 1 S - 1 , k 6 =0.0249µM - 1 S - 1 and K i app =0.499µM. To develop a pharmacophore model, we explored the binding sites of compound 1 and 7 in PTP1B. These modeling results were in agreement with our findings, which revealed that the inhibitory activities are tightly related to caged motif and prenyl group in A ring. Copyright © 2017 Elsevier Ltd. All rights reserved.

10 CFR Appendix S to Part 50 - Earthquake Engineering Criteria for Nuclear Power Plants

Code of Federal Regulations, 2010 CFR

2010-01-01

... under part 50, or a design certification, combined license, design approval, or manufacturing license... license, design approval, or manufacturing license is required by §§ 50.34(a)(12), 50.34(b)(10), or 10 CFR... design for a nuclear power facility. Manufacturing license means a license, issued under subpart F of...

Capabilities and application of a dedicated conventional bomber force in 1993. Student report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thomits, J.R.

1988-04-01

The removal of intermediate-range ballistic missiles as a result of the INF treaty presents conventional balance-of-force implications that will be difficult for NATO to redress in the short term. This study evaluates how a dedicated conventional B-52 force, updated with presently available or programmed technologies, could be applied to overcome the conventional-force imbalance.

21 CFR 529.50 - Amikacin sulfate intrauterine solution.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Amikacin sulfate intrauterine solution. 529.50... Amikacin sulfate intrauterine solution. (a) Specifications. Each milliliter of sterile aqueous solution contains 250 milligrams of amikacin (as the sulfate). (b) Sponsor. See No. 000856 and 059130 in § 510.600(c...

50 CFR 218.11 - Permissible methods of taking.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 10 2013-10-01 2013-10-01 false Permissible methods of taking. 218.11... Range Complex) § 218.11 Permissible methods of taking. (a) Under Letters of Authorization issued... following species, by the indicated method of take and the indicated number of times: (1) Level B Harassment...

50 CFR 216.4 - Other laws and regulations.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false Other laws and regulations. 216.4 Section... MAMMALS Introduction § 216.4 Other laws and regulations. (a) Federal. Nothing in this part, nor any permit... relating to wildlife and fisheries, health, quarantine, agriculture, or customs. (b) State laws or...

50 CFR 216.4 - Other laws and regulations.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 50 Wildlife and Fisheries 10 2014-10-01 2014-10-01 false Other laws and regulations. 216.4 Section... MAMMALS Introduction § 216.4 Other laws and regulations. (a) Federal. Nothing in this part, nor any permit... relating to wildlife and fisheries, health, quarantine, agriculture, or customs. (b) State laws or...

50 CFR 218.31 - Permissible methods of taking.

Code of Federal Regulations, 2012 CFR

2012-10-01

...); (x) Melon-headed whales (Peponocephala electra)—100 (an average of 20 annually); (xi) False killer... annually); (xiv) Pygmy killer whale (Ferresa attenuatta)—50 (an average of 10 annually); (xv) Rough-toothed... method of take and the indicated number of times: (1) Level B Harassment: (i) Sperm whale (Physeter...

50 CFR 218.31 - Permissible methods of taking.

Code of Federal Regulations, 2011 CFR

2011-10-01

...); (x) Melon-headed whales (Peponocephala electra)—100 (an average of 20 annually); (xi) False killer... annually); (xiv) Pygmy killer whale (Ferresa attenuatta)—50 (an average of 10 annually); (xv) Rough-toothed... method of take and the indicated number of times: (1) Level B Harassment: (i) Sperm whale (Physeter...

50 CFR 680.3 - Relation to other laws.

Code of Federal Regulations, 2013 CFR

2013-10-01

....3 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... governing the conservation and management of king crab and Tanner crab in the BSAI area are contained in 50... requirements using the ADF&G “Intent to Operate” registration form and “Fish Tickets.” (b) Sport, personal use...

50 CFR 680.3 - Relation to other laws.

Code of Federal Regulations, 2011 CFR

2011-10-01

....3 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... governing the conservation and management of king crab and Tanner crab in the BSAI area are contained in 50... requirements using the ADF&G “Intent to Operate” registration form and “Fish Tickets.” (b) Sport, personal use...

50 CFR 680.3 - Relation to other laws.

Code of Federal Regulations, 2014 CFR

2014-10-01

....3 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... governing the conservation and management of king crab and Tanner crab in the BSAI area are contained in 50... requirements using the ADF&G “Intent to Operate” registration form and “Fish Tickets.” (b) Sport, personal use...

50 CFR 680.3 - Relation to other laws.

Code of Federal Regulations, 2010 CFR

2010-10-01

....3 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... governing the conservation and management of king crab and Tanner crab in the BSAI area are contained in 50... requirements using the ADF&G “Intent to Operate” registration form and “Fish Tickets.” (b) Sport, personal use...

50 CFR 680.3 - Relation to other laws.

Code of Federal Regulations, 2012 CFR

2012-10-01

....3 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... governing the conservation and management of king crab and Tanner crab in the BSAI area are contained in 50... requirements using the ADF&G “Intent to Operate” registration form and “Fish Tickets.” (b) Sport, personal use...

Mitchells Over the Pacific: The Dynamics of B-25 Innovation

DTIC Science & Technology

2013-06-01

began modifying the B- 25 to increase its self -defense capability. The B-25B was the version employed by the Army Air Forces (AAF) during its first...guns in the nose, waist, and floor along with a .50-caliber machine gun in the tail.31 Internally, the B-25A added armor for the aircrew and self ...Forces in World War II, vol. 1, 439. 50 Doyle, B-25 Mitchell, 10. 19 within the aircraft with a 160-gallon rubber fuel bag and ten five-gallon fuel

Advanced Configurations for Very Large Subsonic Transport Airplanes

NASA Technical Reports Server (NTRS)

McMasters, John H.; Paisley, David J.; Hubert, Richard J.; Kroo, Ilan; Bofah, Kwasi K.; Sullivan, John P.; Drela, Mark

1996-01-01

Recent aerospace industry interest in developing a subsonic commercial transport airplane with 50 percent greater passenger capacity than the largest existing aircraft in this category (the Boeing 747-400 with approximately 400-450 seats) has generated a range of proposals based largely on the configuration paradigm established nearly 50 years ago with the Boeing B-47 bomber. While this basic configuration paradigm has come to dominate subsonic commercial airplane development since the advent of the Boeing 707/Douglas DC-8 in the mid-1950's, its extrapolation to the size required to carry more than 600-700 passengers raises several questions. To explore these and a number of related issues, a team of Boeing, university, and NASA engineers was formed under the auspices of the NASA Advanced Concepts Program. The results of a Research Analysis focused on a large, unconventional transport airplane configuration for which Boeing has applied for a patent are the subject of this report. It should be noted here that this study has been conducted independently of the Boeing New Large Airplane (NLA) program, and with the exception of some generic analysis tools which may be common to this effort and the NLA (as will be described later), no explicit Boeing NLA data other than that published in the open literature has been used in the conduct of the study reported here.

Antiviral properties of prodelphinidin B-2 3'-O-gallate from green tea leaf.

PubMed

Cheng, Hua-Yew; Lin, Chun-Ching; Lin, Ta-Chen

2002-07-01

Prodelphinidin B-2 3-O-gallate, a proanthocyanidin gallate isolated from green tea leaf, was investigated for its anti-herpes simplex virus type 2 properties in vitro. Prodelphinidin B-2 3'-O-gallate exhibited antiviral activity with IC50 of 5.0 +/-1.0 microM and 1.6 +/-0.3 pM for XTT and plaque reduction (PRA) assays, respectively. Cytotoxicity assay had shown that prodelphinidin B-2 3'-O-gallate possessed cytotoxic effect toward Vero cell at concentration higher than its IC50. The 50% cytotoxic concentration for cell growth (CC50) was 33.3 +/- 3.7 microM. Thus, the selectivity index (SI) (ratio of IC50 to CC50) for XTT assay and PRA was 6.7 and 20.8, respectively. Prodelphinidin B-2 3'-O-gallate significantly reduced viral infectivity at concentrations 10 microM or more. Result of time-of-addition studies suggested that prodelphinidin B-2 3'-O-gallate affected the late stage of HSV-2 infection. In addition, it was also shown to inhibit the virus from attaching and penetrating into the cell. Thus, prodelphinidin B-2 3'-O-gallate was concluded to possess antiviral activity with mechanism of inhibiting viral attachment and penetration, and disturbing the late stage of viral infection.

A bipolar outflow of ionized gas in K3-50A: H76 alpha radio recombination line and continuum observations of K3-50

NASA Technical Reports Server (NTRS)

Depree, C. G.; Goss, W. M.; Palmer, Patrick; Rubin, Robert H.

1994-01-01

The H II regions near K3-50 (G70.3 + 1.6) have been imaged at high angular resolution (approximately 1 sec .3) in the continuum and the recombination lines H76(sub alpha and He76(sub alpha) using the Very Large Array (VLA). The helium line is detected in only the brightest component K3-50A while the hydrogen line is detected in three components (K3-50A, B and C1). K3-50A shows a pronounced velocity gradient of approximately 150 km/sec/pc along its major axis (P.A. = 160 deg); in addition a wide range of line widths are observed, from 20 to 65 km/sec. Kinematics from the line data and the morphology of the continuum emission suggest that the ionized material associated with K3-50A is undergoing a high-velocity bipolar outflow.

50 CFR 38.11 - Prostitution and lewd behavior.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Prostitution and lewd behavior. 38.11... Prostitution and lewd behavior. No person on Midway Atoll National Wildlife Refuge will: (a) Engage in prostitution. “Prostitution” means the giving or receiving of the body for sexual intercourse for hire; or (b...

50 CFR 216.272 - Permissible methods of taking.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 10 2013-10-01 2013-10-01 false Permissible methods of taking. 216.272... (SOCAL Range Complex) § 216.272 Permissible methods of taking. (a) Under Letters of Authorization issued... species, by the indicated method of take and the indicated number of times: (1) Level B Harassment (±10...

50 CFR 218.2 - Permissible methods of taking.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 10 2013-10-01 2013-10-01 false Permissible methods of taking. 218.2... (VACAPES Range Complex) § 218.2 Permissible methods of taking. (a) Under Letters of Authorization issued... following species, by the indicated method of take and the indicated number of times: (1) Level B Harassment...

50 CFR 218.31 - Permissible methods of taking.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 10 2013-10-01 2013-10-01 false Permissible methods of taking. 218.31....31 Permissible methods of taking. (a) Under Letters of Authorization issued pursuant to §§ 216.106 of... method of take and the indicated number of times: (1) Level B Harassment: (i) Sperm whale (Physeter...

50 CFR 216.272 - Permissible methods of taking.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 10 2012-10-01 2012-10-01 false Permissible methods of taking. 216.272... (SOCAL Range Complex) § 216.272 Permissible methods of taking. (a) Under Letters of Authorization issued... species, by the indicated method of take and the indicated number of times: (1) Level B Harassment (±10...

9 CFR 590.50 - Temperature and labeling requirements.

Code of Federal Regulations, 2012 CFR

2012-01-01

...) Refrigeration of Shell Eggs § 590.50 Temperature and labeling requirements. (a) No shell egg handler shall... stored and transported under refrigeration at an ambient temperature of no greater than 45°F (7.2°C). (b... ultimate consumer unless they are labeled to indicate that refrigeration is required. (c) Any producer...

9 CFR 590.50 - Temperature and labeling requirements.

Code of Federal Regulations, 2011 CFR

2011-01-01

...) Refrigeration of Shell Eggs § 590.50 Temperature and labeling requirements. (a) No shell egg handler shall... stored and transported under refrigeration at an ambient temperature of no greater than 45°F (7.2°C). (b... ultimate consumer unless they are labeled to indicate that refrigeration is required. (c) Any producer...

26 CFR 1.50B-5 - Limitations with respect to certain persons.

Code of Federal Regulations, 2014 CFR

2014-04-01

... paragraph. (b) Regulated investment companies and real estate investment trusts. (1) In the case of a regulated investment company or a real estate investment trust subject to taxation under subchapter M... real estate investment trust taxable income, as the case may be. For purposes of the preceding sentence...

26 CFR 1.50B-5 - Limitations with respect to certain persons.

Code of Federal Regulations, 2011 CFR

2011-04-01

... paragraph. (b) Regulated investment companies and real estate investment trusts. (1) In the case of a regulated investment company or a real estate investment trust subject to taxation under subchapter M... real estate investment trust taxable income, as the case may be. For purposes of the preceding sentence...

26 CFR 1.50B-5 - Limitations with respect to certain persons.

Code of Federal Regulations, 2012 CFR

2012-04-01

... paragraph. (b) Regulated investment companies and real estate investment trusts. (1) In the case of a regulated investment company or a real estate investment trust subject to taxation under subchapter M... real estate investment trust taxable income, as the case may be. For purposes of the preceding sentence...

26 CFR 1.50B-5 - Limitations with respect to certain persons.

Code of Federal Regulations, 2013 CFR

2013-04-01

... paragraph. (b) Regulated investment companies and real estate investment trusts. (1) In the case of a regulated investment company or a real estate investment trust subject to taxation under subchapter M... real estate investment trust taxable income, as the case may be. For purposes of the preceding sentence...

26 CFR 1.50B-5 - Limitations with respect to certain persons.

Code of Federal Regulations, 2010 CFR

2010-04-01

... paragraph. (b) Regulated investment companies and real estate investment trusts. (1) In the case of a regulated investment company or a real estate investment trust subject to taxation under subchapter M... real estate investment trust taxable income, as the case may be. For purposes of the preceding sentence...

Extracting a representative loading spectrum from recorded flight data

NASA Technical Reports Server (NTRS)

Denyer, Anthony G.

1994-01-01

One of the more important ingredients when computing the life of a structure is the loading environment. This paper describes the development of an aircraft loading spectrum that closely matches the service experience, thus allowing a more accurate assessment of the structural life. The paper outlines the flight loads data collection system, the procedures developed to compile and interpret the service records and the techniques used to define a spectrum suitable for structural life analysis. The areas where the procedures were tailored to suit the special situation of the USAF B-1B bomber are also discussed. the results of the methodology verification, achieved by comparing the generated spectra with the results of strain gage monitoring during service operations, are also presented.

Spin Research Vehicle (SRV) in B-52 Captive Flight

NASA Technical Reports Server (NTRS)

1981-01-01

This in-flight photo of NASA's B-52 mothership shows the bomber carrying a subscale model of an Air Force F-15, a remotely piloted vehicle that was used to conduct spin research. The F-15 Remotely Piloted Research Vehicles (RPRV) was air launched from the B-52 at approximately 45,000 feet and was controlled by a pilot in a ground cockpit complete with flight controls and a television screen. The F-15 model in this particular configuration was known as the Spin Research Vehicle (SRV). NASA B-52, Tail Number 008, is an air launch carrier aircraft, 'mothership,' as well as a research aircraft platform that has been used on a variety of research projects. The aircraft, a 'B' model built in 1952 and first flown on June 11, 1955, is the oldest B-52 in flying status and has been used on some of the most significant research projects in aerospace history. Some of the significant projects supported by B-52 008 include the X-15, the lifting bodies, HiMAT (highly maneuverable aircraft technology), Pegasus, validation of parachute systems developed for the space shuttle program (solid-rocket-booster recovery system and the orbiter drag chute system), and the X-38. The B-52 served as the launch vehicle on 106 X-15 flights and flew a total of 159 captive-carry and launch missions in support of that program from June 1959 to October 1968. Information gained from the highly successful X-15 program contributed to the Mercury, Gemini, and Apollo human spaceflight programs as well as space shuttle development. Between 1966 and 1975, the B-52 served as the launch aircraft for 127 of the 144 wingless lifting body flights. In the 1970s and 1980s, the B-52 was the launch aircraft for several aircraft at what is now the Dryden Flight Research Center, Edwards, California, to study spin-stall, high-angle-of attack, and maneuvering characteristics. These included the 3/8-scale F-15/spin research vehicle (SRV), the HiMAT (Highly Maneuverable Aircraft Technology) research vehicle, and the DAST

21 CFR 50.50 - IRB duties.

Code of Federal Regulations, 2010 CFR

2010-04-01

... review clinical investigations involving children as subjects covered by this subpart D and approve only... SUBJECTS Additional Safeguards for Children in Clinical Investigations § 50.50 IRB duties. In addition to...

49 CFR 178.50 - Specification 4B welded or brazed steel cylinders.

Code of Federal Regulations, 2014 CFR

2014-10-01

... service pressure of at least 150 but not over 500 psig. Cylinders closed in by spinning process are not authorized. (b) Steel. Open-hearth, electric or basic oxygen process steel of uniform quality must be used... using equipment and processes adequate to ensure that each cylinder produced conforms to the...

49 CFR 178.50 - Specification 4B welded or brazed steel cylinders.

Code of Federal Regulations, 2012 CFR

2012-10-01

... service pressure of at least 150 but not over 500 psig. Cylinders closed in by spinning process are not authorized. (b) Steel. Open-hearth, electric or basic oxygen process steel of uniform quality must be used... using equipment and processes adequate to ensure that each cylinder produced conforms to the...

49 CFR 178.50 - Specification 4B welded or brazed steel cylinders.

Code of Federal Regulations, 2013 CFR

2013-10-01

... service pressure of at least 150 but not over 500 psig. Cylinders closed in by spinning process are not authorized. (b) Steel. Open-hearth, electric or basic oxygen process steel of uniform quality must be used... using equipment and processes adequate to ensure that each cylinder produced conforms to the...

VizieR Online Data Catalog: Transiting planet WASP-50b (Tregloan-Reed+, 2013)

NASA Astrophysics Data System (ADS)

Tregloan-Reed, J.; Southworth, J.

2018-05-01

Two high-quality light curves of transits of the extrasolar planetary system WASP-50 are presented. They were obtained using the 3.6m NTT at ESO La Silla, Chile, in the Gunn r passband. The errorbars for each transit have been scaled so the best-fitting model (obtained using the JKTEBOP code) has a reduced chi-squared value of 1.0. (1 data file).

32 CFR Appendix B to Part 50 - Overseas Life Insurance Registration Program

Code of Federal Regulations, 2012 CFR

2012-07-01

.... Insurers must be listed in Best's Life-Health Insurance Reports and be assigned a rating of B+ (Very Good... that occur during the fiscal year of registration must be reported to the MWR Policy Directorate at the.... Failure to report such material changes may result in termination of registration regardless of how it...

32 CFR Appendix B to Part 50 - Overseas Life Insurance Registration Program

Code of Federal Regulations, 2013 CFR

2013-07-01

.... Insurers must be listed in Best's Life-Health Insurance Reports and be assigned a rating of B+ (Very Good... that occur during the fiscal year of registration must be reported to the MWR Policy Directorate at the.... Failure to report such material changes may result in termination of registration regardless of how it...

32 CFR Appendix B to Part 50 - Overseas Life Insurance Registration Program

Code of Federal Regulations, 2014 CFR

2014-07-01

.... Insurers must be listed in Best's Life-Health Insurance Reports and be assigned a rating of B+ (Very Good... that occur during the fiscal year of registration must be reported to the MWR Policy Directorate at the.... Failure to report such material changes may result in termination of registration regardless of how it...

Serious adverse drug reaction in a woman with hyperemesis gravidarum after first exposure to vitamin B complex containing vitamins B1, B6 and B12.