32 CFR 861.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 6 2013-07-01 2013-07-01 false Definitions. 861.3 Section 861.3 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT DEPARTMENT OF DEFENSE... Command, or USCINCTRANS; and (4) Secretary of Defense. (Note: A DOD-level body, the Commercial Airlift...

32 CFR 86.1 - Purpose.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 1 2010-07-01 2010-07-01 false Purpose. 86.1 Section 86.1 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE PERSONNEL, MILITARY AND CIVILIAN CRIMINAL HISTORY... Bureau of Investigation (FBI) fingerprint check and State Criminal History Repositories (SCHR) checks of...

21 CFR 861.38 - Standards advisory committees.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Standards advisory committees. 861.38 Section 861.38 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... Development and Publication § 861.38 Standards advisory committees. (a) The Food and Drug Administration will...

10 CFR 861.7 - Applicability of other laws.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 10 Energy 4 2014-01-01 2014-01-01 false Applicability of other laws. 861.7 Section 861.7 Energy DEPARTMENT OF ENERGY CONTROL OF TRAFFIC AT NEVADA TEST SITE § 861.7 Applicability of other laws. Nothing in this part shall be construed to affect the applicability of the provisions of State laws or of other...

10 CFR 861.7 - Applicability of other laws.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 10 Energy 4 2013-01-01 2013-01-01 false Applicability of other laws. 861.7 Section 861.7 Energy DEPARTMENT OF ENERGY CONTROL OF TRAFFIC AT NEVADA TEST SITE § 861.7 Applicability of other laws. Nothing in this part shall be construed to affect the applicability of the provisions of State laws or of other...

14 CFR 91.861 - Base level.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Base level. 91.861 Section 91.861... level. (a) U.S. Operators. The base level of a U.S. operator is equal to the number of owned or leased... to paragraphs (a) (1) and (2). (1) The base level of a U.S. operator shall be increased by a number...

26 CFR 1.861-6 - Sale of real property.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Sale of real property. 1.861-6 Section 1.861-6...) INCOME TAXES Tax Based on Income from Sources within Or Without the United States § 1.861-6 Sale of real... of section 1001 and the regulations thereunder, derived from the sale or other disposition of real...

21 CFR 861.7 - Contents of standards.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Contents of standards. 861.7 Section 861.7 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... performance standard established under this part will include such provisions as the Food and Drug...

21 CFR 861.5 - Statement of policy.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Statement of policy. 861.5 Section 861.5 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES... duties under this section, the Food and Drug Administration will, to the maximum extent practical: (a...

42 CFR 493.861 - Standard; Unexpected antibody detection.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 42 Public Health 5 2010-10-01 2010-10-01 false Standard; Unexpected antibody detection. 493.861 Section 493.861 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... for Laboratories Performing Tests of Moderate Complexity (including the Subcategory), High Complexity...

42 CFR 493.861 - Standard; Unexpected antibody detection.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 42 Public Health 5 2011-10-01 2011-10-01 false Standard; Unexpected antibody detection. 493.861 Section 493.861 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... for Laboratories Performing Tests of Moderate Complexity (including the Subcategory), High Complexity...

Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.

PubMed

Choy, Meng S; Li, Yang; Machado, Luciana E S F; Kunze, Micha B A; Connors, Christopher R; Wei, Xingyu; Lindorff-Larsen, Kresten; Page, Rebecca; Peti, Wolfgang

2017-02-16

Protein function originates from a cooperation of structural rigidity, dynamics at different timescales, and allostery. However, how these three pillars of protein function are integrated is still only poorly understood. Here we show how these pillars are connected in Protein Tyrosine Phosphatase 1B (PTP1B), a drug target for diabetes and cancer that catalyzes the dephosphorylation of numerous substrates in essential signaling pathways. By combining new experimental and computational data on WT-PTP1B and ≥10 PTP1B variants in multiple states, we discovered a fundamental and evolutionarily conserved CH/π switch that is critical for positioning the catalytically important WPD loop. Furthermore, our data show that PTP1B uses conformational and dynamic allostery to regulate its activity. This shows that both conformational rigidity and dynamics are essential for controlling protein activity. This connection between rigidity and dynamics at different timescales is likely a hallmark of all enzyme function. Copyright © 2017 Elsevier Inc. All rights reserved.

Development of semi-rigid cables for low temperature superconducting detectors

NASA Astrophysics Data System (ADS)

Kushino, Akihiro; Kasai, Soichi

We are developing semi-rigid cables for accurate readout of superconducting radiation/particle detectors and other low temperature experiments. The center conductor with a diameter of 0.86 mm is separated with seamless metal outer conductor by dielectric material, polytetrafluoroethylene. We used various metal materials with low thermal conductivity for the electrical conductors such as stainless-steel, cupro-nickel, brass, beryllium-copper, phosphor-bronze, niobium-titanium, and niobium. In addition to the conventional semi-rigid cables, low-pass-filter type cables were manufactured and evaluated to cut the high frequency noise into superconducting detectors. We measured their low thermal conductance and attenuation property up to 10 GHz below the liquid helium temperature.

26 CFR 1.861-6 - Sale of real property.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 26 Internal Revenue 9 2012-04-01 2012-04-01 false Sale of real property. 1.861-6 Section 1.861-6... Sale of real property. Gross income from sources within the United States includes gain, computed under... disposition of real property located in the United States. For the treatment of capital gains and losses, see...

26 CFR 1.861-6 - Sale of real property.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 26 Internal Revenue 9 2014-04-01 2014-04-01 false Sale of real property. 1.861-6 Section 1.861-6... Sale of real property. Gross income from sources within the United States includes gain, computed under... disposition of real property located in the United States. For the treatment of capital gains and losses, see...

26 CFR 1.861-6 - Sale of real property.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 26 Internal Revenue 9 2011-04-01 2011-04-01 false Sale of real property. 1.861-6 Section 1.861-6... Sale of real property. Gross income from sources within the United States includes gain, computed under... disposition of real property located in the United States. For the treatment of capital gains and losses, see...

26 CFR 1.861-6 - Sale of real property.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 26 Internal Revenue 9 2013-04-01 2013-04-01 false Sale of real property. 1.861-6 Section 1.861-6... Sale of real property. Gross income from sources within the United States includes gain, computed under... disposition of real property located in the United States. For the treatment of capital gains and losses, see...

26 CFR 1.861-10 - Special allocations of interest expense.

Code of Federal Regulations, 2010 CFR

2010-04-01

.... In addition, assets which are the subject of qualified nonrecourse indebtedness or integrated... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Special allocations of interest expense. 1.861... § 1.861-10 Special allocations of interest expense. (a)-(d) [Reserved] (e) Treatment of certain...

Development and evaluation of thin semi-rigid cables for superconducting detectors

NASA Astrophysics Data System (ADS)

Kasai, Soichi; Kushino, Akihiro

2015-03-01

We are developing semi-rigid cables for accurate readout of superconducting radiation/particle detectors and other low temperature experiments. The center conductor with a diameter of 0.86 mm is separated with seamless metal outer conductor by dielectric material, polytetrafluoroethylene. We used various metal materials with low thermal conductivity for the electrical conductors such as stainless-steel, cupro-nickel, brass, beryllium-copper, phosphor-bronze, niobium-titanium, and niobium. In addition to the conventional semi-rigid cables, low-pass-filter-type cables were manufactured and evaluated to cut the high frequency noise into superconducting detectors. We measured their low thermal conductance and attenuation property up to 10GHz below the liquid helium temperature.

Toward Seamless Weather-Climate Prediction with a Global Cloud Resolving Model

DTIC Science & Technology

2016-01-14

distribution is unlimited. TOWARD SEAMLESS WEATHER- CLIMATE PREDICTION WITH A GLOBAL CLOUD RESOLVING MODEL PI: Tim Li IPRC/SOEST, University of Hawaii at...Project Final Report 3. DATES COVERED (From - To) 1 May 2012 - 30 September 2015 4. TITLE AND SUBTITLE TOWARD SEAMLESS WEATHER- CLIMATE PREDICTION WITH...A GLOBAL CLOUD RESOLVING MODEL 5a. CONTRACT NUMBER 5b. GRANT NUMBER N000141210450 5c. PROGRAM ELEMENT NUMBER ONR Marine Meteorology Program 6

32 CFR 861.7 - Disclosure of voluntarily provided safety-related information.

Code of Federal Regulations, 2013 CFR

2013-07-01

...) Processing requests for disclosure of voluntarily provided safety-related information. Requests for public... will protect the information from public disclosure, and that it will not release such information...-related information. 861.7 Section 861.7 National Defense Department of Defense (Continued) DEPARTMENT OF...

32 CFR 861.7 - Disclosure of voluntarily provided safety-related information.

Code of Federal Regulations, 2014 CFR

2014-07-01

...) Processing requests for disclosure of voluntarily provided safety-related information. Requests for public... will protect the information from public disclosure, and that it will not release such information...-related information. 861.7 Section 861.7 National Defense Department of Defense (Continued) DEPARTMENT OF...

32 CFR 861.7 - Disclosure of voluntarily provided safety-related information.

Code of Federal Regulations, 2012 CFR

2012-07-01

...) Processing requests for disclosure of voluntarily provided safety-related information. Requests for public... will protect the information from public disclosure, and that it will not release such information...-related information. 861.7 Section 861.7 National Defense Department of Defense (Continued) DEPARTMENT OF...

32 CFR 861.7 - Disclosure of voluntarily provided safety-related information.

Code of Federal Regulations, 2011 CFR

2011-07-01

...) Processing requests for disclosure of voluntarily provided safety-related information. Requests for public... will protect the information from public disclosure, and that it will not release such information...-related information. 861.7 Section 861.7 National Defense Department of Defense (Continued) DEPARTMENT OF...

10 CFR 861.3 - Definitions.

Code of Federal Regulations, 2011 CFR

2011-01-01

... ENERGY CONTROL OF TRAFFIC AT NEVADA TEST SITE § 861.3 Definitions. As used in this part: (a) DOE means.... A perimeter description is attached as Appendix A to this part. (c) Nevada Test Site Traffic Regulations means the traffic directives promulgated by the Manager of the Nevada Site Office pursuant to...

10 CFR 861.3 - Definitions.

Code of Federal Regulations, 2014 CFR

2014-01-01

... ENERGY CONTROL OF TRAFFIC AT NEVADA TEST SITE § 861.3 Definitions. As used in this part: (a) DOE means.... A perimeter description is attached as Appendix A to this part. (c) Nevada Test Site Traffic Regulations means the traffic directives promulgated by the Manager of the Nevada Site Office pursuant to...

10 CFR 861.3 - Definitions.

Code of Federal Regulations, 2012 CFR

2012-01-01

... ENERGY CONTROL OF TRAFFIC AT NEVADA TEST SITE § 861.3 Definitions. As used in this part: (a) DOE means.... A perimeter description is attached as Appendix A to this part. (c) Nevada Test Site Traffic Regulations means the traffic directives promulgated by the Manager of the Nevada Site Office pursuant to...

10 CFR 861.3 - Definitions.

Code of Federal Regulations, 2013 CFR

2013-01-01

... ENERGY CONTROL OF TRAFFIC AT NEVADA TEST SITE § 861.3 Definitions. As used in this part: (a) DOE means.... A perimeter description is attached as Appendix A to this part. (c) Nevada Test Site Traffic Regulations means the traffic directives promulgated by the Manager of the Nevada Site Office pursuant to...

10 CFR 861.3 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... ENERGY CONTROL OF TRAFFIC AT NEVADA TEST SITE § 861.3 Definitions. As used in this part: (a) DOE means.... A perimeter description is attached as Appendix A to this part. (c) Nevada Test Site Traffic Regulations means the traffic directives promulgated by the Manager of the Nevada Site Office pursuant to...

49 CFR 180.212 - Repair of seamless DOT 3-series specification cylinders and seamless UN pressure receptacles.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Repair of seamless DOT 3-series specification..., Maintenance and Use of Cylinders § 180.212 Repair of seamless DOT 3-series specification cylinders and seamless UN pressure receptacles. (a) General requirements for repair of DOT 3-series cylinders and UN...

47 CFR 22.861 - Emission limitations.

Code of Federal Regulations, 2010 CFR

2010-10-01

... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PUBLIC MOBILE SERVICES Air-Ground Radiotelephone Service Commercial Aviation Air-Ground Systems § 22.861 Emission limitations. The rules in this section govern the spectral characteristics of emissions for commercial aviation systems...

26 CFR 1.861-9 - Allocation and apportionment of interest expense.

Code of Federal Regulations, 2010 CFR

2010-04-01

... of such an election, other than in conjunction with an election to use the fair market value method... further guidance, see § 1.861-9T(a) through (f)(3)(i). (f)(3)(ii) Manner of election. The election shall... corporate shareholders. (ii) Manner of election. The election to use the asset method described in § 1.861...

26 CFR 1.861-16 - Income from certain craft first leased after December 28, 1980.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Income from certain craft first leased after... the United States § 1.861-16 Income from certain craft first leased after December 28, 1980. (a) General rule. If a taxpayer— (1) Owns a qualified craft (as defined in paragraph (b) of this section). (2...

Active control using control allocation for UAVs with seamless morphing wing

NASA Astrophysics Data System (ADS)

Wang, Zheng-jie; Sun, Yin-di; Yang, Da-qing; Guo, Shi-jun

2012-04-01

In this paper, a small seamless morphing wing aircraft of MTOW=51 kg is investigated. The leading edge (LE) and trailing edge (TE) control surfaces are positioned in the wing section in span wise. Based on the studying results of aeroelastic wing characteristics, the controller should be designed depending on the flight speed. Compared with a wing of rigid hinged aileron, the morphing wing produces the rolling moment by deflecting the flexible TE and LE surfaces. An iteration method of pseudo-inverse allocation and quadratic programming allocation within the constraints of actuators have be investigated to solve the nonlinear control allocation caused by the aerodynamics of the effectors. The simulation results will show that the control method based on control allocation can achieve the control target.

Active control using control allocation for UAVs with seamless morphing wing

NASA Astrophysics Data System (ADS)

Wang, Zheng-jie; Sun, Yin-di; Yang, Da-qing; Guo, Shi-jun

2011-11-01

In this paper, a small seamless morphing wing aircraft of MTOW=51 kg is investigated. The leading edge (LE) and trailing edge (TE) control surfaces are positioned in the wing section in span wise. Based on the studying results of aeroelastic wing characteristics, the controller should be designed depending on the flight speed. Compared with a wing of rigid hinged aileron, the morphing wing produces the rolling moment by deflecting the flexible TE and LE surfaces. An iteration method of pseudo-inverse allocation and quadratic programming allocation within the constraints of actuators have be investigated to solve the nonlinear control allocation caused by the aerodynamics of the effectors. The simulation results will show that the control method based on control allocation can achieve the control target.

26 CFR 1.861-17 - Allocation and apportionment of research and experimental expenditures.

Code of Federal Regulations, 2011 CFR

2011-04-01

... of the group has changed methods. (f) Special rules for partnerships—(1) Research and experimental... and Wiring Equipment (SIC Industry Group 364). Thus, X's research and experimental expenses are... experimental expenditures. 1.861-17 Section 1.861-17 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF...

26 CFR 1.861-17 - Allocation and apportionment of research and experimental expenditures.

Code of Federal Regulations, 2012 CFR

2012-04-01

... of the group has changed methods. (f) Special rules for partnerships—(1) Research and experimental... and Wiring Equipment (SIC Industry Group 364). Thus, X's research and experimental expenses are... experimental expenditures. 1.861-17 Section 1.861-17 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF...

26 CFR 1.861-17 - Allocation and apportionment of research and experimental expenditures.

Code of Federal Regulations, 2014 CFR

2014-04-01

... of the group has changed methods. (f) Special rules for partnerships—(1) Research and experimental... and Wiring Equipment (SIC Industry Group 364). Thus, X's research and experimental expenses are... experimental expenditures. 1.861-17 Section 1.861-17 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF...

26 CFR 1.861-17 - Allocation and apportionment of research and experimental expenditures.

Code of Federal Regulations, 2010 CFR

2010-04-01

... of the group has changed methods. (f) Special rules for partnerships—(1) Research and experimental... and Wiring Equipment (SIC Industry Group 364). Thus, X's research and experimental expenses are... experimental expenditures. 1.861-17 Section 1.861-17 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF...

26 CFR 1.861-17 - Allocation and apportionment of research and experimental expenditures.

Code of Federal Regulations, 2013 CFR

2013-04-01

... of the group has changed methods. (f) Special rules for partnerships—(1) Research and experimental... and Wiring Equipment (SIC Industry Group 364). Thus, X's research and experimental expenses are... experimental expenditures. 1.861-17 Section 1.861-17 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF...

Time to make the doughnuts: Building and shaping seamless tubes.

PubMed

Sundaram, Meera V; Cohen, Jennifer D

2017-07-01

A seamless tube is a very narrow-bore tube that is composed of a single cell with an intracellular lumen and no adherens or tight junctions along its length. Many capillaries in the vertebrate vascular system are seamless tubes. Seamless tubes also are found in invertebrate organs, including the Drosophila trachea and the Caenorhabditis elegans excretory system. Seamless tube cells can be less than a micron in diameter, and they can adopt very simple "doughnut-like" shapes or very complex, branched shapes comparable to those of neurons. The unusual topology and varied shapes of seamless tubes raise many basic cell biological questions about how cells form and maintain such structures. The prevalence of seamless tubes in the vascular system means that answering such questions has significant relevance to human health. In this review, we describe selected examples of seamless tubes in animals and discuss current models for how seamless tubes develop and are shaped, focusing particularly on insights that have come from recent studies in Drosophila and C. elegans. Copyright © 2016 Elsevier Ltd. All rights reserved.

Social Media and Seamless Learning: Lessons Learned

ERIC Educational Resources Information Center

Panke, Stefanie; Kohls, Christian; Gaiser, Birgit

2017-01-01

The paper discusses best practice approaches and metrics for evaluation that support seamless learning with social media. We draw upon the theoretical frameworks of social learning theory, transfer learning (bricolage), and educational design patterns to elaborate upon different ideas for ways in which social media can support seamless learning.…

The Role of MreB in Escherichia Coli's Cellular Rigidity

NASA Astrophysics Data System (ADS)

Shaevitz, Joshua W.

2009-03-01

Bacteria possess homologs of all three classes of eukaryotic cytoskeletal proteins. These filamentous proteins have been shown to localize proteins essential for a number of cell-biological processes in prokaryotes such as cell growth and division. However, to date, there has been no direct evidence that the cytoskeleton in bacteria bears mechanical loads or can generate physical forces than are used by the cell. I will present evidence from combined fluorescence and force microscopy measurements that MreB, an actin homolog, is responsible for half of Escherichia coli's cellular rigidity. These data support an interpretation in which the cytoskeleton, the peptidoglycan cell wall and a large turgor pressure work together to give gram-negative cells their mechanical properties.

10 CFR 861.4 - Use of site streets.

Code of Federal Regulations, 2010 CFR

2010-01-01

... OF ENERGY CONTROL OF TRAFFIC AT NEVADA TEST SITE § 861.4 Use of site streets. All persons using the streets of the Nevada Test Site shall do so in a careful and safe manner. (a) The Nevada Test Site Traffic Regulations supplement this section by identifying the specific traffic requirements relating to such matters...

Coordinate references for the indoor/outdoor seamless positioning

NASA Astrophysics Data System (ADS)

Ruan, Ling; Zhang, Ling; Long, Yi; Cheng, Fei

2018-05-01

Indoor positioning technologies are being developed rapidly, and seamless positioning which connected indoor and outdoor space is a new trend. The indoor and outdoor positioning are not applying the same coordinate system and different indoor positioning scenes uses different indoor local coordinate reference systems. A specific and unified coordinate reference frame is needed as the space basis and premise in seamless positioning application. Trajectory analysis of indoor and outdoor integration also requires a uniform coordinate reference. However, the coordinate reference frame in seamless positioning which can applied to various complex scenarios is lacking of research for a long time. In this paper, we proposed a universal coordinate reference frame in indoor/outdoor seamless positioning. The research focus on analysis and classify the indoor positioning scenes and put forward the coordinate reference system establishment and coordinate transformation methods in each scene. And, through some experiments, the calibration method feasibility was verified.

Hydrodynamics of suspensions of passive and active rigid particles: a rigid multiblob approach

DOE PAGES

Usabiaga, Florencio Balboa; Kallemov, Bakytzhan; Delmotte, Blaise; ...

2016-01-12

We develop a rigid multiblob method for numerically solving the mobility problem for suspensions of passive and active rigid particles of complex shape in Stokes flow in unconfined, partially confined, and fully confined geometries. As in a number of existing methods, we discretize rigid bodies using a collection of minimally resolved spherical blobs constrained to move as a rigid body, to arrive at a potentially large linear system of equations for the unknown Lagrange multipliers and rigid-body motions. Here we develop a block-diagonal preconditioner for this linear system and show that a standard Krylov solver converges in a modest numbermore » of iterations that is essentially independent of the number of particles. Key to the efficiency of the method is a technique for fast computation of the product of the blob-blob mobility matrix and a vector. For unbounded suspensions, we rely on existing analytical expressions for the Rotne-Prager-Yamakawa tensor combined with a fast multipole method (FMM) to obtain linear scaling in the number of particles. For suspensions sedimented against a single no-slip boundary, we use a direct summation on a graphical processing unit (GPU), which gives quadratic asymptotic scaling with the number of particles. For fully confined domains, such as periodic suspensions or suspensions confined in slit and square channels, we extend a recently developed rigid-body immersed boundary method by B. Kallemov, A. P. S. Bhalla, B. E. Griffith, and A. Donev (Commun. Appl. Math. Comput. Sci. 11 (2016), no. 1, 79-141) to suspensions of freely moving passive or active rigid particles at zero Reynolds number. We demonstrate that the iterative solver for the coupled fluid and rigid-body equations converges in a bounded number of iterations regardless of the system size. In our approach, each iteration only requires a few cycles of a geometric multigrid solver for the Poisson equation, and an application of the block-diagonal preconditioner

Aerodynamic analysis of seamless horizontal stabilizer

NASA Astrophysics Data System (ADS)

Nithya, S.; Kanimozhi, S.

2017-05-01

This project presents an investigative view into the concept of seamless aeroelastic wing and hingeless flexible trailing edge. Wings are designed to provide maximum lift and minimal drag and weight. But with conventional wings where rivets are used and the control surfaces are separately hinged, parasite drag comes into play. This project is about analysing a smooth seamless wing with hinge-less flexible trailing edge. This type of wing reduces the drag considerably and the hinge-less trailing edge leads to a minimal control demand and reduces the noise produced when the aircraft comes for landing. Seamless aeroelastic wing will function as an integrated one piece lifting and control surface. It has been designed to enhance a desirable wing camber for control by deflecting a hinge-less flexible trailing edge part instead of a traditional hinged control surface. This kind of flexible wing can be achieved either by a curved beam and disc actuation mechanism or by piezo-electric materials, whose shape change can be achieved by electricity. The intent of this project is to analyze the effects of introducing the concept of Seamless Wing to the horizontal stabilizer. While the removal of rivets and serrations that hinge the elevators to the stabilizer reduces the overall drag by a reasonable value, the overall concept of a control surface-less stabilizer where the maneuvers are done by deflecting the trailing edge offers better maneuverability.

26 CFR 1.861-8 - Computation of taxable income from sources within the United States and from other sources and...

Code of Federal Regulations, 2010 CFR

2010-04-01

... income. [Reserved]. For guidance, see § 1.861-8T(c)(1). (2) Apportionment based on assets. [Reserved.... [Reserved]. For guidance, see § 1.861-8T(d)(2). (e) Allocation and apportionment of certain deductions—(1... section. (2) Interest. [Reserved]. For guidance, see § 1.861-8T(e)(2). (3) Research and experimental...

26 CFR 1.861-7 - Sale of personal property.

Code of Federal Regulations, 2010 CFR

2010-04-01

... particular manner for the primary purpose of tax avoidance, the foregoing rules will not be applied. In such...-7 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Tax Based on Income from Sources within Or Without the United States § 1.861-7 Sale...

34 CFR 86.1 - What is the purpose of the Drug and Alcohol Abuse Prevention regulations?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false What is the purpose of the Drug and Alcohol Abuse Prevention regulations? 86.1 Section 86.1 Education Office of the Secretary, Department of Education DRUG AND... the Drug-Free Schools and Communities Act Amendments of 1989, which added section 1213 to the Higher...

Genus Ranges of 4-Regular Rigid Vertex Graphs

PubMed Central

Buck, Dorothy; Dolzhenko, Egor; Jonoska, Nataša; Saito, Masahico; Valencia, Karin

2016-01-01

A rigid vertex of a graph is one that has a prescribed cyclic order of its incident edges. We study orientable genus ranges of 4-regular rigid vertex graphs. The (orientable) genus range is a set of genera values over all orientable surfaces into which a graph is embedded cellularly, and the embeddings of rigid vertex graphs are required to preserve the prescribed cyclic order of incident edges at every vertex. The genus ranges of 4-regular rigid vertex graphs are sets of consecutive integers, and we address two questions: which intervals of integers appear as genus ranges of such graphs, and what types of graphs realize a given genus range. For graphs with 2n vertices (n > 1), we prove that all intervals [a, b] for all a < b ≤ n, and singletons [h, h] for some h ≤ n, are realized as genus ranges. For graphs with 2n − 1 vertices (n ≥ 1), we prove that all intervals [a, b] for all a < b ≤ n except [0, n], and [h, h] for some h ≤ n, are realized as genus ranges. We also provide constructions of graphs that realize these ranges. PMID:27807395

32 CFR 861.6 - DOD review of foreign air carriers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... DEPARTMENT OF DEFENSE COMMERCIAL AIR TRANSPORTATION QUALITY AND SAFETY REVIEW PROGRAM § 861.6 DOD review of... carriers seeking to provide or providing air transportation services under a contract or Military Air.... Foreign air carriers seeking to provide or providing air transportation services under a contract or...

An Ichor-dependent apical extracellular matrix regulates seamless tube shape and integrity

PubMed Central

Rosa, Jeffrey B.; Metzstein, Mark M.

2018-01-01

During sprouting angiogenesis in the vertebrate vascular system, and primary branching in the Drosophila tracheal system, specialized tip cells direct branch outgrowth and network formation. When tip cells lumenize, they form subcellular (seamless) tubes. How these seamless tubes are made, shaped and maintained remains poorly understood. Here we characterize a Drosophila mutant called ichor (ich), and show that ich is essential for the integrity and shape of seamless tubes in tracheal terminal cells. We find that Ich regulates seamless tubulogenesis via its role in promoting the formation of a mature apical extracellular matrix (aECM) lining the lumen of the seamless tubes. We determined that ich encodes a zinc finger protein (CG11966) that acts, as a transcriptional activator required for the expression of multiple aECM factors, including a novel membrane-anchored trypsin protease (CG8213). Thus, the integrity and shape of seamless tubes are regulated by the aECM that lines their lumens. PMID:29309404

32 CFR 861.5 - DOD Commercial Airlift Review Board procedures.

Code of Federal Regulations, 2010 CFR

2010-07-01

... AIRCRAFT DEPARTMENT OF DEFENSE COMMERCIAL AIR TRANSPORTATION QUALITY AND SAFETY REVIEW PROGRAM § 861.5 DOD... procedures apply to air carriers seeking to provide or already providing air transportation services to DOD... provide air transportation service to DOD; the review and approval or disapproval of air carriers in the...

49 CFR 179.500 - Specification DOT-107A * * * * seamless steel tank car tanks.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Specification DOT-107A * * * * seamless steel tank...) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.500 Specification DOT-107A * * * * seamless steel tank car tanks. ...

Development of thin semi-rigid coaxial cables as low-pass filter using bilayer structure in center conductors

NASA Astrophysics Data System (ADS)

Kushino, Akihiro; Yamamoto, Yusei; Okuyama, Tetsuya; Kasai, Soichi

We have developed and evaluated thin semi-rigid coaxial cables as the noise filter for readout in low temperature experiments. The cables reported have 0.86 mm outer diameters consisting of seamless outer conductor, polytetrafluoroethylene (PTFE) dielectric, and center conductor made of superconducting niobium-titanium (NbTi). Each center conductor has surficial cladding made of normal conductor in different thickness. We had reported that we can adjust attenuation magnitude and cut-off frequency of the semi-rigid cable in the range about 100 500 MHz by controlling cable length and/or thickness of cladding. We newly manufactured this type of low-pass filter cables using stainless-steel (SUS304) as the material for cladding which has higher electrical resistivity than that of cupro-nickel (CuNi). It enables high filtering efficiency, i.e. large attenuation at the same frequency, compared to those made of conventional CuNi-based low-pass-filter cables.

Web-Based Seamless Migration for Task-Oriented Mobile Distance Learning

ERIC Educational Resources Information Center

Zhang, Degan; Li, Yuan-chao; Zhang, Huaiyu; Zhang, Xinshang; Zeng, Guangping

2006-01-01

As a new kind of computing paradigm, pervasive computing will meet the requirements of human being that anybody maybe obtain services in anywhere and at anytime, task-oriented seamless migration is one of its applications. Apparently, the function of seamless mobility is suitable for mobile services, such as mobile Web-based learning. In this…

75 FR 69052 - Certain Seamless Carbon and Alloy Steel Standard, Line, and Pressure Pipe From the People's...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-10

... seamless carbon and alloy steel standard, line, and pressure pipe (``seamless pipe'') from the People's... seamless pipe from the PRC. See Certain Seamless Carbon and Alloy Steel Standard, Line, and Pressure Pipe..., and its negative determination of critical circumstances. See Certain Seamless Carbon and Alloy Steel...

75 FR 13255 - Certain Seamless Carbon and Alloy Steel Standard, Line, and Pressure Pipe from the People's...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-19

... seamless carbon and alloy steel standard, line, and pressure pipe (``seamless pipe'') from the People's... countervailing duty investigations of seamless pipe from the PRC. See Certain Seamless Carbon and Alloy Steel... Investigation, 74 FR 52744 (October 14, 2009) and Certain Seamless Carbon and Alloy Steel Standard, Line, and...

32 CFR 861.4 - DOD air transportation quality and safety requirements.

Code of Federal Regulations, 2010 CFR

2010-07-01

... programs and business practices that not only ensure good service but also enhance the safety, operational...) “Equivalent to the services sought by DOD” means service offered to qualify for DOD approval must be... § 861.4 DOD air transportation quality and safety requirements. (a) General. The DOD, as a customer of...

Low-Carbon Metallurgical Concepts for Seamless Octg Pipe

NASA Astrophysics Data System (ADS)

Mohrbacher, Hardy

Seamless pipes are available with wall gages of up to 100 mm and outer diameters up to around 700 mm. Such pipes are typically used for oil country tubular goods as well as for structural applications. Due to market requirements the demand for high strength grade seamless pipes is increasing. Many applications need high toughness in addition to high strength. The different rolling processes applied in production depend on wall gage and pipe diameter. The continuous mandrel mill process is used to produce smaller gages and diameters; plug mill processing covers medium gages and diameters; Pilger mill processing allows producing larger diameters and heavy wall gage. In all these processes only a limited degree of thermo-mechanical rolling can be achieved. Therefore strengthening and toughening by severe grain refinement employing a conventional niobium-based microalloying concept is not easily achievable. Accordingly, high strength and toughness seamless pipe is typically produced via a quench and tempering process route. This route however is costly and above that often constitutes a capacity bottleneck in the mill. Innovative low-carbon alloy concepts however do allow producing strength up to grade X70 at very high toughness directly off the rolling plant, i.e., without quench and tempering treatment. Due to the low carbon content also welding is much facilitated. The paper reveals the metallurgical principles, which are based on appropriate niobium and molybdenum alloying. Additionally the paper demonstrates how heavy gaged seamless pipes up to 70 mm wall thickness can be produced based on a low-carbon Nb-Mo approach using quench and temper treatment.

Learning Analytics for Supporting Seamless Language Learning Using E-Book with Ubiquitous Learning System

ERIC Educational Resources Information Center

Mouri, Kousuke; Uosaki, Noriko; Ogata, Hiroaki

2018-01-01

Seamless learning has been recognized as an effective learning approach across various dimensions including formal and informal learning contexts, individual and social learning, and physical world and cyberspace. With the emergence of seamless learning, the majority of the current research focuses on realizing a seamless learning environment at…

The National Map seamless digital elevation model specifications

USGS Publications Warehouse

Archuleta, Christy-Ann M.; Constance, Eric W.; Arundel, Samantha T.; Lowe, Amanda J.; Mantey, Kimberly S.; Phillips, Lori A.

2017-08-02

This specification documents the requirements and standards used to produce the seamless elevation layers for The National Map of the United States. Seamless elevation data are available for the conterminous United States, Hawaii, Alaska, and the U.S. territories, in three different resolutions—1/3-arc-second, 1-arc-second, and 2-arc-second. These specifications include requirements and standards information about source data requirements, spatial reference system, distribution tiling schemes, horizontal resolution, vertical accuracy, digital elevation model surface treatment, georeferencing, data source and tile dates, distribution and supporting file formats, void areas, metadata, spatial metadata, and quality assurance and control.

Rigid versus semi-rigid orthotic use following TMC arthroplasty: a randomized controlled trial.

PubMed

Prosser, Rosemary; Hancock, Mark J; Nicholson, Leslie; Merry, Cathy; Thorley, Felicity; Wheen, Douglass

2014-01-01

The trapeziometacarpal (TMC) joint of the human thumb is the second most common joint in the hand affected by osteoarthritis. TMC arthroplasty is a common procedure used to alleviate symptoms. No randomized controlled trials have been published on the efficacy of different post-operative orthotic regimes. Fifty six participants who underwent TMC arthroplasty were allocated to either rigid orthotic or semi-rigid orthotic groups. Both groups started an identical exercise program at two weeks following surgery. Outcome measures were assessed by an assessor blinded to group allocation. The primary outcome was the Patient Rated Wrist and Hand Evaluation (PRWHE) and secondary outcomes included the Michigan Hand Questionnaire (MHQ), thumb palmar abduction, first metacarpophalangeal extension and three point pinch grip. Measures were taken pre-operatively, at six weeks, three months and one year post-operatively. Between-group differences were analyzed with linear regression. Both groups performed equally well. There was no significant between-group difference for PRWHE scores (0.47, CI -11.5 to 12.4), including subscales for pain and function, or for any of the secondary outcomes at one year follow-up. We found no difference in outcomes between using a rigid or semi-rigid orthosis after TMC arthroplasty. Patient comfort, cost and availability may determine choice between orthoses in clinical practice. 1b RCT. Copyright © 2014 Hanley & Belfus. Published by Elsevier Inc. All rights reserved.

Seamless Learning Environments in Higher Education with Mobile Devices and Examples

ERIC Educational Resources Information Center

Marín, Victoria I.; Jääskelä, Päivikki; Häkkinen, Päivi; Juntunen, Merja; Rasku-Puttonen, Helena; Vesisenaho, Mikko

2016-01-01

The use of seamless learning environments that have the potential to support lifelong learning anytime and anywhere has become a reality. In this sense, many educational institutions have started to consider introducing seamless learning environments into their programs. The aim of this study is to analyze how various educational university…

14 CFR 27.861 - Fire protection of structure, controls, and other parts.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fire protection of structure, controls, and... Protection § 27.861 Fire protection of structure, controls, and other parts. Each part of the structure, controls, rotor mechanism, and other parts essential to a controlled landing that would be affected by...

14 CFR 27.861 - Fire protection of structure, controls, and other parts.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Fire protection of structure, controls, and... Protection § 27.861 Fire protection of structure, controls, and other parts. Each part of the structure, controls, rotor mechanism, and other parts essential to a controlled landing that would be affected by...

14 CFR 29.861 - Fire protection of structure, controls, and other parts.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Fire protection of structure, controls, and... Protection § 29.861 Fire protection of structure, controls, and other parts. Each part of the structure, controls, and the rotor mechanism, and other parts essential to controlled landing and (for category A...

14 CFR 29.861 - Fire protection of structure, controls, and other parts.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 1 2011-01-01 2011-01-01 false Fire protection of structure, controls, and... Protection § 29.861 Fire protection of structure, controls, and other parts. Each part of the structure, controls, and the rotor mechanism, and other parts essential to controlled landing and (for category A...

75 FR 26273 - Certain Seamless Carbon and Alloy Steel Standard, Line, and Pressure Pipe From China

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-11

... certain seamless carbon and alloy steel standard, line, and pressure pipe (``seamless SLP pipe... China of seamless SLP pipe, and that such products are being sold in the United States at less than fair...

The effects of rigid motions on elastic network model force constants

PubMed Central

Lezon, Timothy R.

2012-01-01

Elastic network models provide an efficient way to quickly calculate protein global dynamics from experimentally determined structures. The model’s single parameter, its force constant, determines the physical extent of equilibrium fluctuations. The values of force constants can be calculated by fitting to experimental data, but the results depend on the type of experimental data used. Here we investigate the differences between calculated values of force constants _t to data from NMR and X-ray structures. We find that X-ray B factors carry the signature of rigid-body motions, to the extent that B factors can be almost entirely accounted for by rigid motions alone. When fitting to more refined anisotropic temperature factors, the contributions of rigid motions are significantly reduced, indicating that the large contribution of rigid motions to B factors is a result of over-fitting. No correlation is found between force constants fit to NMR data and those fit to X-ray data, possibly due to the inability of NMR data to accurately capture protein dynamics. PMID:22228562

The effects of rigid motions on elastic network model force constants.

PubMed

Lezon, Timothy R

2012-04-01

Elastic network models provide an efficient way to quickly calculate protein global dynamics from experimentally determined structures. The model's single parameter, its force constant, determines the physical extent of equilibrium fluctuations. The values of force constants can be calculated by fitting to experimental data, but the results depend on the type of experimental data used. Here, we investigate the differences between calculated values of force constants and data from NMR and X-ray structures. We find that X-ray B factors carry the signature of rigid-body motions, to the extent that B factors can be almost entirely accounted for by rigid motions alone. When fitting to more refined anisotropic temperature factors, the contributions of rigid motions are significantly reduced, indicating that the large contribution of rigid motions to B factors is a result of over-fitting. No correlation is found between force constants fit to NMR data and those fit to X-ray data, possibly due to the inability of NMR data to accurately capture protein dynamics. Copyright © 2011 Wiley Periodicals, Inc.

A seamless phase IIB/III adaptive outcome trial: design rationale and implementation challenges.

PubMed

Chen, Y H Joshua; Gesser, Richard; Luxembourg, Alain

2015-02-01

The licensed four-valent prophylactic human papillomavirus vaccine is highly efficacious in preventing cervical, vulvar, vaginal, and anal cancers and related precancers caused by human papillomavirus types 6, 11, 16, and 18. These four types account for approximately 70% of cervical cancers. A nine-valent human papillomavirus vaccine, including the four original types (6, 11, 16, and 18) plus the next five most prevalent types in cervical cancer (31, 33, 45, 52, and 58) could provide approximately 90% overall cervical cancer coverage. To expedite the nine-valent human papillomavirus vaccine clinical development, an adaptive, seamless Phase IIB/III outcome trial with ∼ 15,000 subjects was conducted to facilitate dose formulation selection and provide pivotal evidence of safety and efficacy for regulatory registrations. We discuss the design rationale and implementation challenges of the outcome trial, focusing on the adaptive feature of the seamless Phase IIB/III design. Subjects were enrolled in two parts (Part A and Part B). Approximately 1240 women, 16-26 years of age, were enrolled in Part A for Phase IIB evaluation and equally randomized to one of three dose formulations of the nine-valent human papillomavirus vaccine or the four-valent human papillomavirus vaccine (active control). Based on an interim analysis of immunogenicity and safety, one dose formulation of the nine-valent human papillomavirus vaccine was selected for evaluation in the Phase III part of the study. Subjects enrolled in Part A who received the selected dose formulation of the nine-valent human papillomavirus vaccine or four-valent human papillomavirus vaccine continued to be followed up and contributed to the final efficacy and safety analyses. In addition, ∼ 13,400 women 16-26 years of age were enrolled in Part B, randomized to nine-valent human papillomavirus vaccine at the selected dose formulation or four-valent human papillomavirus vaccine, and followed for immunogenicity

Rigid particulate matter sensor

DOEpatents

Hall, Matthew [Austin, TX

2011-02-22

A sensor to detect particulate matter. The sensor includes a first rigid tube, a second rigid tube, a detection surface electrode, and a bias surface electrode. The second rigid tube is mounted substantially parallel to the first rigid tube. The detection surface electrode is disposed on an outer surface of the first rigid tube. The detection surface electrode is disposed to face the second rigid tube. The bias surface electrode is disposed on an outer surface of the second rigid tube. The bias surface electrode is disposed to face the detection surface electrode on the first rigid tube. An air gap exists between the detection surface electrode and the bias surface electrode to allow particulate matter within an exhaust stream to flow between the detection and bias surface electrodes.

75 FR 69125 - Certain Seamless Carbon and Alloy Steel Standard, Line, and Pressure Pipe From China

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-10

... standard, line, and pressure pipe (``seamless SLP pipe''), provided for in subheadings 7304.19.10, 7304.19... Charlotte R. Lane determines that the domestic seamless SLP pipe industry is materially injured by reason of... notification of preliminary determinations by Commerce that imports of seamless SLP pipe from China were...

QUENCH STUDIES AND PREHEATING ANALYSIS OF SEAMLESS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Palczewski, Ari; Geng, Rongli; Eremeev, Grigory

One of the alternative manufacturing technologies for SRF cavities is hydroforming from seamless tubes. Although this technology has produced cavities with gradient and Q-values comparable to standard EBW/EP cavities, a few questions remain. One of these questions is whether the quench mechanism in hydroformed cavities is the same as in standard electron beam welded cavities. Towards this effort Jefferson Lab performed quench studies on 2 9 cell seamless hydroformed cavities. These cavities include DESY's - Z163 and Z164 nine-cell cavities hydroformed at DESY. Initial Rf test results Z163 were published in SRF2011. In this report we will present post JLABmore » surface re-treatment quench studies for each cavity. The data will include OST and T-mapping quench localization as well as quench location preheating analysis comparing them to the observations in standard electron beam welded cavities.« less

Digital Correction of Motion Artifacts in Microscopy Image Sequences Collected from Living Animals Using Rigid and Non-Rigid Registration

PubMed Central

Lorenz, Kevin S.; Salama, Paul; Dunn, Kenneth W.; Delp, Edward J.

2013-01-01

Digital image analysis is a fundamental component of quantitative microscopy. However, intravital microscopy presents many challenges for digital image analysis. In general, microscopy volumes are inherently anisotropic, suffer from decreasing contrast with tissue depth, lack object edge detail, and characteristically have low signal levels. Intravital microscopy introduces the additional problem of motion artifacts, resulting from respiratory motion and heartbeat from specimens imaged in vivo. This paper describes an image registration technique for use with sequences of intravital microscopy images collected in time-series or in 3D volumes. Our registration method involves both rigid and non-rigid components. The rigid registration component corrects global image translations, while the non-rigid component manipulates a uniform grid of control points defined by B-splines. Each control point is optimized by minimizing a cost function consisting of two parts: a term to define image similarity, and a term to ensure deformation grid smoothness. Experimental results indicate that this approach is promising based on the analysis of several image volumes collected from the kidney, lung, and salivary gland of living rodents. PMID:22092443

A seamless ubiquitous emergency medical service for crisis situations.

PubMed

Lin, Bor-Shing

2016-04-01

In crisis situations, a seamless ubiquitous communication is necessary to provide emergency medical service to save people's lives. An excellent prehospital emergency medicine provides immediate medical care to increase the survival rate of patients. On their way to the hospital, ambulance personnel must transmit real-time and uninterrupted patient information to the hospital to apprise the physician of the situation and provide options to the ambulance personnel. In emergency and crisis situations, many communication channels can be unserviceable because of damage to equipment or loss of power. Thus, data transmission over wireless communication to achieve uninterrupted network services is a major obstacle. This study proposes a mobile middleware for cognitive radio (CR) for improving the wireless communication link. CRs can sense their operating environment and optimize the spectrum usage so that the mobile middleware can integrate the existing wireless communication systems with a seamless communication service in heterogeneous network environments. Eventually, the proposed seamless mobile communication middleware was ported into an embedded system, which is compatible with the actual network environment without the need for changing the original system architecture. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

24 CFR 3280.706 - Oil piping systems.

Code of Federal Regulations, 2010 CFR

2010-04-01

... the Standard Specification for Seamless Copper Water Tube, ASTM B88-93, or shall comply with ASTM B280... supply connection(s) shall be rigidly anchored to a structural member within 6 inches of the supply... shall be checked for oil leaks with fuel oil of the same grade that will be burned in the appliance. No...

Non-rigid Earth rotation series

NASA Astrophysics Data System (ADS)

Pashkevich, V. V.

2008-04-01

The last years a lot of attempts to derive a high-precision theory of the non-rigid Earth rotation was carried out. For these purposes the different transfer functions are used. Usually these transfer func- tions are applied to the series representing the nutation in longitude and in obliquity of the rigid Earth rotation with respect to the ecliptic of date. The aim of this investigation is a construction of the new high- precision non-rigid Earth rotation series (SN9000), dynamically adequate to the DE404/LE404 ephemeris over 2000 years, which are expressed as a function of Euler angles ψ, θ and φ with respect to the fixed ecliptic plane and equinox J2000.0. The early stages of the previous investigation: 1. The high-precision numerical solution of the rigid Earth rotation have been constructed (V.V.Pashkevich, G.I.Eroshkin and A.Brzezinski, 2004), (V.V.Pashkevich and G.I.Eroshkin, Proceedings of Journees 2004). The initial con- ditions have been calculated from SMART97 (P.Bretagnon, G.Francou, P.Rocher, J.L.Simon,1998). The discrepancies between the numerical solution and the semi-analytical solution SMART97 were obtained in Euler angles over 2000 years with one-day spacing. 2. Investigation of the discrepancies is carried out by the least squares and by the spectral analysis algorithms (V.V.Pashkevich and G.I.Eroshkin, Proceedings of Journees 2005). The high-precision rigid Earth rotation series S9000 are determined (V.V.Pashkevich and G.I.Eroshkin, 2005 ). The next stage of this investigation: 3. The new high-precision non-rigid Earth rotation series (SN9000), which are expressed as a function of Euler angles, are constructed by using the method (P.Bretagnon, P.M.Mathews, J.-L.Simon: 1999) and the transfer function MHB2002 (Mathews, P. M., Herring, T. A., and Buffett B. A., 2002).

Geometric and electrostatic modeling using molecular rigidity functions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mu, Lin; Xia, Kelin; Wei, Guowei

Geometric and electrostatic modeling is an essential component in computational biophysics and molecular biology. Commonly used geometric representations admit geometric singularities such as cusps, tips and self-intersecting facets that lead to computational instabilities in the molecular modeling. Our present work explores the use of flexibility and rigidity index (FRI), which has a proved superiority in protein B-factor prediction, for biomolecular geometric representation and associated electrostatic analysis. FRI rigidity surfaces are free of geometric singularities. We propose a rigidity based Poisson–Boltzmann equation for biomolecular electrostatic analysis. These approaches to surface and electrostatic modeling are validated by a set of 21 proteins.more » Our results are compared with those of established methods. Finally, being smooth and analytically differentiable, FRI rigidity functions offer excellent curvature analysis, which characterizes concave and convex regions on protein surfaces. Polarized curvatures constructed by using the product of minimum curvature and electrostatic potential is shown to predict potential protein–ligand binding sites.« less

Geometric and electrostatic modeling using molecular rigidity functions

DOE PAGES

Mu, Lin; Xia, Kelin; Wei, Guowei

2017-03-01

Geometric and electrostatic modeling is an essential component in computational biophysics and molecular biology. Commonly used geometric representations admit geometric singularities such as cusps, tips and self-intersecting facets that lead to computational instabilities in the molecular modeling. Our present work explores the use of flexibility and rigidity index (FRI), which has a proved superiority in protein B-factor prediction, for biomolecular geometric representation and associated electrostatic analysis. FRI rigidity surfaces are free of geometric singularities. We propose a rigidity based Poisson–Boltzmann equation for biomolecular electrostatic analysis. These approaches to surface and electrostatic modeling are validated by a set of 21 proteins.more » Our results are compared with those of established methods. Finally, being smooth and analytically differentiable, FRI rigidity functions offer excellent curvature analysis, which characterizes concave and convex regions on protein surfaces. Polarized curvatures constructed by using the product of minimum curvature and electrostatic potential is shown to predict potential protein–ligand binding sites.« less

What Seams Do We Remove in Mobile-Assisted Seamless Learning? A Critical Review of the Literature

ERIC Educational Resources Information Center

Wong, Lung-Hsiang; Looi, Chee-Kit

2011-01-01

Seamless learning refers to the seamless integration of the learning experiences across various dimensions including formal and informal learning contexts, individual and social learning, and physical world and cyberspace. Inspired by the exposition by Chan et al. (2006) on the seamless learning model supported by the setting of one or more mobile…

49 CFR 179.500 - Specification DOT-107A * * * * seamless steel tank car tanks.

Code of Federal Regulations, 2011 CFR

2011-10-01

... car tanks. 179.500 Section 179.500 Transportation Other Regulations Relating to Transportation...) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.500 Specification DOT-107A * * * * seamless steel tank car tanks. ...

49 CFR 179.500 - Specification DOT-107A * * * * seamless steel tank car tanks.

Code of Federal Regulations, 2010 CFR

2010-10-01

... car tanks. 179.500 Section 179.500 Transportation Other Regulations Relating to Transportation... REGULATIONS SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.500 Specification DOT-107A * * * * seamless steel tank car tanks. ...

49 CFR 179.500 - Specification DOT-107A * * * * seamless steel tank car tanks.

Code of Federal Regulations, 2012 CFR

2012-10-01

... car tanks. 179.500 Section 179.500 Transportation Other Regulations Relating to Transportation...) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.500 Specification DOT-107A * * * * seamless steel tank car tanks. ...

49 CFR 179.500 - Specification DOT-107A * * * * seamless steel tank car tanks.

Code of Federal Regulations, 2013 CFR

2013-10-01

... car tanks. 179.500 Section 179.500 Transportation Other Regulations Relating to Transportation...) SPECIFICATIONS FOR TANK CARS Specification for Cryogenic Liquid Tank Car Tanks and Seamless Steel Tanks (Classes DOT-113 and 107A) § 179.500 Specification DOT-107A * * * * seamless steel tank car tanks. ...

Seamless service: maintaining momentum.

PubMed

Grinstead, N; Timoney, R

1994-01-01

Describes the process used by the Mater Infirmorum Hospital in Belfast in 1992-1994 to achieve high quality care (Seamless Service), motivate staff to deliver and measure performance. Aims of the project include focusing the organization on the customer, improving teamwork and motivation at all levels. After comprehensive data collection from GPs, patients and staff management forums developed a full TQM strategy to gain support and maintain momentum including innovative staff events (every staff member was given the opportunity to attend) where multilevel, multidisciplinary workshops enabled staff to design customer care standards, develop teams and lead customer-driven change.

Conformally encapsulated multi-electrode arrays with seamless insulation

DOEpatents

Tabada, Phillipe J.; Shah, Kedar G.; Tolosa, Vanessa; Pannu, Satinderall S.; Tooker, Angela; Delima, Terri; Sheth, Heeral; Felix, Sarah

2016-11-22

Thin-film multi-electrode arrays (MEA) having one or more electrically conductive beams conformally encapsulated in a seamless block of electrically insulating material, and methods of fabricating such MEAs using reproducible, microfabrication processes. One or more electrically conductive traces are formed on scaffold material that is subsequently removed to suspend the traces over a substrate by support portions of the trace beam in contact with the substrate. By encapsulating the suspended traces, either individually or together, with a single continuous layer of an electrically insulating material, a seamless block of electrically insulating material is formed that conforms to the shape of the trace beam structure, including any trace backings which provide suspension support. Electrical contacts, electrodes, or leads of the traces are exposed from the encapsulated trace beam structure by removing the substrate.

Understanding geological processes: Visualization of rigid and non-rigid transformations

NASA Astrophysics Data System (ADS)

Shipley, T. F.; Atit, K.; Manduca, C. A.; Ormand, C. J.; Resnick, I.; Tikoff, B.

2012-12-01

Visualizations are used in the geological sciences to support reasoning about structures and events. Research in cognitive sciences offers insights into the range of skills of different users, and ultimately how visualizations might support different users. To understand the range of skills needed to reason about earth processes we have developed a program of research that is grounded in the geosciences' careful description of the spatial and spatiotemporal patterns associated with earth processes. In particular, we are pursuing a research program that identifies specific spatial skills and investigates whether and how they are related to each other. For this study, we focus on a specific question: Is there an important distinction in the geosciences between rigid and non-rigid deformation? To study a general spatial thinking skill we employed displays with non-geological objects that had been altered by rigid change (rotation), and two types of non-rigid change ("brittle" (or discontinuous) and "ductile" (or continuous) deformation). Disciplinary scientists (geosciences and chemistry faculty), and novices (non-science faculty and undergraduate psychology students) answered questions that required them to visualize the appearance of the object before the change. In one study, geologists and chemists were found to be superior to non-science faculty in reasoning about rigid rotations (e.g., what an object would look like from a different perspective). Geologists were superior to chemists in reasoning about brittle deformations (e.g., what an object looked like before it was broken - here the object was a word cut into many fragments displaced in different directions). This finding is consistent with two hypotheses: 1) Experts are good at visualizing the types of changes required for their domain; and 2) Visualization of rigid and non-rigid changes are not the same skill. An additional important finding is that there was a broad range of skill in both rigid and non-rigid

75 FR 6183 - Certain Seamless Carbon and Alloy Steel Standard, Line, and Pressure Pipe from the People's...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-08

... antidumping duty investigation on certain seamless carbon and alloy steel standard, line, and pressure pipe from the People's Republic of China. See Certain Seamless Carbon and Alloy Steel Standard, Line, and... DEPARTMENT OF COMMERCE INTERNATIONAL TRADE ADMINISTRATION (A-570-956) Certain Seamless Carbon and...

78 FR 41369 - Certain Small Diameter Carbon and Alloy Seamless Standard, Line and Pressure Pipe From Romania...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-10

... Carbon and Alloy Seamless Standard, Line and Pressure Pipe From Romania: Preliminary Results of..., line and pressure pipe (small diameter seamless pipe) from Romania. The period of review (POR) is... and Alloy Seamless Standard, Line and Pressure Pipe from Romania,'' dated concurrently with this...

Preparation of a micropatterned rigid-soft composite substrate for probing cellular rigidity sensing.

PubMed

Wong, Stephanie; Guo, Wei-hui; Hoffecker, Ian; Wang, Yu-li

2014-01-01

Substrate rigidity has been recognized as an important property that affects cellular physiology and functions. While the phenomenon has been well recognized, understanding the underlying mechanism may be greatly facilitated by creating a microenvironment with designed rigidity patterns. This chapter describes in detail an optimized method for preparing substrates with micropatterned rigidity, taking advantage of the ability to dehydrate polyacrylamide gels for micropatterning with photolithography, and subsequently rehydrate the gel to regain the original elastic state. While a wide range of micropatterns may be prepared, typical composite substrates consist of micron-sized islands of rigid photoresist grafted on the surface of polyacrylamide hydrogels of defined rigidity. These islands are displaced by cellular traction forces, for a distance determined by the size of the island, the rigidity of the underlying hydrogel, and the magnitude of traction forces. Domains of rigidity may be created using this composite material to allow systematic investigations of rigidity sensing and durotaxis. Copyright © 2014 Elsevier Inc. All rights reserved.

Seamless contiguity method for parallel segmentation of remote sensing image

NASA Astrophysics Data System (ADS)

Wang, Geng; Wang, Guanghui; Yu, Mei; Cui, Chengling

2015-12-01

Seamless contiguity is the key technology for parallel segmentation of remote sensing data with large quantities. It can be effectively integrate fragments of the parallel processing into reasonable results for subsequent processes. There are numerous methods reported in the literature for seamless contiguity, such as establishing buffer, area boundary merging and data sewing. et. We proposed a new method which was also based on building buffers. The seamless contiguity processes we adopt are based on the principle: ensuring the accuracy of the boundary, ensuring the correctness of topology. Firstly, block number is computed based on data processing ability, unlike establishing buffer on both sides of block line, buffer is established just on the right side and underside of the line. Each block of data is segmented respectively and then gets the segmentation objects and their label value. Secondly, choose one block(called master block) and do stitching on the adjacent blocks(called slave block), process the rest of the block in sequence. Through the above processing, topological relationship and boundaries of master block are guaranteed. Thirdly, if the master block polygons boundaries intersect with buffer boundary and the slave blocks polygons boundaries intersect with block line, we adopt certain rules to merge and trade-offs them. Fourthly, check the topology and boundary in the buffer area. Finally, a set of experiments were conducted and prove the feasibility of this method. This novel seamless contiguity algorithm provides an applicable and practical solution for efficient segmentation of massive remote sensing image.

77 FR 67336 - Certain Small Diameter Carbon and Alloy Seamless Standard, Line and Pressure Pipe From Romania...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-09

... products subject to the order are small diameter seamless carbon and alloy (other than stainless) steel... Carbon and Alloy Seamless Standard, Line and Pressure Pipe From Romania: Final Results of Antidumping... alloy seamless standard, line and pressure pipe from Romania. The period of review is August 1, 2010...

75 FR 18153 - Certain Large Diameter Carbon and Alloy Seamless Standard, Line, and Pressure Pipe From Japan...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-09

... Carbon and Alloy Seamless Standard, Line, and Pressure Pipe From Japan: Extension of Time Limit for... review of the antidumping duty order on certain large diameter carbon and alloy seamless standard, line... Carbon and Alloy Seamless Standard, Line and Pressure Pipe from Japan: Extension of Time Limit for...

46 CFR 56.60-1 - Acceptable materials and specifications (replaces 123 and Table 126.1 in ASME B31.1).

Code of Federal Regulations, 2014 CFR

2014-10-01

... standards ASME standards Notes Pipe, seamless: A 106 Carbon steel ASME B31.1 A 335 Ferritic alloys ASME B31.1 A 376 Austenitic alloys ASME B31.1 (1). Pipe, seamless and welded: A 53 Types S, F, and E steel... cast: (None applicable) (1 9) Tube, seamless: A 179 Carbon steel heat exchanger and condenser tubes...

46 CFR 56.60-1 - Acceptable materials and specifications (replaces 123 and Table 126.1 in ASME B31.1).

Code of Federal Regulations, 2013 CFR

2013-10-01

... standards ASME standards Notes Pipe, seamless: A 106 Carbon steel ASME B31.1 A 335 Ferritic alloys ASME B31.1 A 376 Austenitic alloys ASME B31.1 (1). Pipe, seamless and welded: A 53 Types S, F, and E steel... cast: (None applicable) (1 9) Tube, seamless: A 179 Carbon steel heat exchanger and condenser tubes...

46 CFR 56.60-1 - Acceptable materials and specifications (replaces 123 and Table 126.1 in ASME B31.1).

Code of Federal Regulations, 2012 CFR

2012-10-01

... standards ASME standards Notes Pipe, seamless: A 106 Carbon steel ASME B31.1 A 335 Ferritic alloys ASME B31.1 A 376 Austenitic alloys ASME B31.1 (1). Pipe, seamless and welded: A 53 Types S, F, and E steel... cast: (None applicable) (1,9) Tube, seamless: A 179 Carbon steel heat exchanger and condenser tubes...

49 CFR 178.37 - Specification 3AA and 3AAX seamless steel cylinders.

Code of Federal Regulations, 2011 CFR

2011-10-01

... conform to the following: (1) A DOT-3AA cylinder is a seamless steel cylinder with a water capacity... a seamless steel cylinder with a water capacity of not less than 1,000 pounds and a service pressure... the weight per unit of length of the straight cylindrical portion filled with water and compressed to...

Analysis of drug resistance in 1,861 strains of Acinetobacter baumannii.

PubMed

Jin, Hao; Qiu, Fan; Ji, Hong Jian; Lu, Qiang

2016-04-01

Acinetobacter baumannii is an emerging human pathogen that causes hospital-acquired infections. The trend in increased antimicrobial resistance limits the choice of effective antimicrobial agents. The present study reports the resistance to Acinetobacter baumannii and analyzes the associations between antibiotic use and resistance rates at a general hospital between 2010 and 2014. A total of 1,861 isolates were obtained from clinical cultures, accounting for 10.33% of all detected bacteria (1,861/18,016). The strains were mainly from respiratory samples (1,628 isolates, 87.5%) and the intensive care unit (696 isolates, 37.4%). The resistance rates of Acinetobacter baumannii to the majority of antibiotics were >50%, particularly the resistance rate to cefoperazone/sulbactam increased from 47.37 in 2011 to 89.25% in 2014. However, the rates of imipenem and cilastatin sodium decreased from 81.03 to 69.44% due to the antibiotic policy. There were Pearson significant associations between the use of three antibiotics and resistance in Acinetobacter baumannii to this drug, piperacillin/tazobactam (r=0.976, P<0.01), gentamicin (r=0.870, P<0.01) and cefoxitin (r=0.741, P<0.05). Therefore, a combination of drugs should be adopted to treat Acinetobacter baumannii infections. Microbiology laboratory support and surveillance policies are essential to control the emergence of multidrug-resistance Acinetobacter baumannii .

"Seamlessly" Learning Chinese: Contextual Meaning Making and Vocabulary Growth in a Seamless Chinese as a Second Language Learning Environment

ERIC Educational Resources Information Center

Wong, Lung-Hsiang; King, Ronnel B.; Chai, Ching Sing; Liu, May

2016-01-01

Second language learners are typically hampered by the lack of a natural environment to use the target language for authentic communication purpose (as a means for "learning by applying"). Thus, we propose MyCLOUD, a mobile-assisted seamless language learning approach that aims to nurture a second language social network that bridges…

Mobile Seamless Technology Enhanced CSL Oral Communication

ERIC Educational Resources Information Center

Lan, Yu-Ju; Lin, Yen-Ting

2016-01-01

The current study aimed at investigating how mobile seamless technology can be used to enhance the pragmatic competence of learners of Chinese as a second language (CSL). 34 overseas CSL learners participated in this study. They were randomly assigned into two groups: the classroom group, executing language tasks in fake contexts in a traditional…

The Estimation of a Rigid Body Motion in the Presence of Noise.

DTIC Science & Technology

1987-07-31

Rigid Body Motion in the Presence of Noise 12. PERSONAL AUTHOR(S) 1S. AYOFDREPRTy 13b.e ad COVRE C4. 10AOUTE OF FUNPING NUBERSlAE...8217, .,_, .,,.. .\\ ..: ., : ’ *-: ,:,.,,. .’ 4 /. .’.’ ’, ’ ,. 9) 7 TRACT The problem of estimating a rigid body motion from two noisy images of an...SI ... ... Cs . I ,-’ ’".’ 1 -, ED 1, D:;.;i,1q L HARVARD UNIVERSITY DzPAILTMNT OP STATIMCS THE ESTIMATION OF A RIGID BODY MOTION IN THE

76 FR 44608 - Carbon and Alloy Seamless Standard, Line, and Pressure Pipe From Japan and Romania; Scheduling of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-26

... Alloy Seamless Standard, Line, and Pressure Pipe From Japan and Romania; Scheduling of Expedited Five-Year Reviews Concerning the Antidumping Duty Orders on Carbon and Alloy Seamless Standard, Line, and... the antidumping duty orders on carbon and alloy seamless standard, line, and pressure pipe from Japan...

78 FR 33809 - Seamless Carbon and Alloy Steel Standard, Line, and Pressure Pipe From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-05

... review of the antidumping duty order on seamless carbon and alloy steel standard, line, and pressure pipe... seamless carbon and alloy steel standard, line, and pressure pipe from the People's Republic of China... DEPARTMENT OF COMMERCE International Trade Administration [A-570-956] Seamless Carbon and Alloy...

Great apes select tools on the basis of their rigidity.

PubMed

Manrique, Héctor Marín; Gross, Alexandra Nam-Mi; Call, Josep

2010-10-01

Wild chimpanzees select tools according to their rigidity. However, little is known about whether choices are solely based on familiarity with the materials or knowledge about tool properties. Furthermore, it is unclear whether tool manipulation is required prior to selection or whether observation alone can suffice. We investigated whether chimpanzees (Pan troglodytes) (n = 9), bonobos (Pan paniscus) (n = 4), orangutans (Pongo pygmaeus) (n = 6), and gorillas (Gorilla gorilla) (n = 2) selected new tools on the basis of their rigidity. Subjects faced an out-of-reach reward and a choice of three tools differing in color, diameter, material, and rigidity. We used 10 different 3-tool sets (1 rigid, 2 flexible). Subjects were unfamiliar with the tools and needed to select and use the rigid tool to retrieve the reward. Experiment 1 showed that subjects chose the rigid tool from the first trial with a 90% success rate. Experiments 2a and 2b addressed the role of manipulation and observation in tool selection. Subjects performed equally well in conditions in which they could manipulate the tools themselves or saw the experimenter manipulate the tools but decreased their performance if they could only visually inspect the tools. Experiment 3 showed that subjects could select flexible tools (as opposed to rigid ones) to meet new task demands. We conclude that great apes spontaneously selected unfamiliar rigid or flexible tools even after gathering minimal observational information. 2010 APA, all rights reserved

77 FR 43806 - Seamless Carbon and Alloy Steel Standard, Line, and Pressure Pipe From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-26

... duty order on seamless carbon and alloy steel standard, line, and pressure pipe from the People's... the antidumping duty order on seamless carbon and alloy steel standard, line, and pressure pipe from... Making Co., Ltd.; Wuxi Seamless Special Pipe Co., Ltd.; Wuxi Sifang Steel Tube Co., Ltd.; Wuxi Zhenda...

76 FR 80333 - Seamless Refined Copper Pipe and Tube From Mexico: Extension of Time Limits for the Preliminary...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-23

... DEPARTMENT OF COMMERCE International Trade Administration [A-428-840] Seamless Refined Copper Pipe... antidumping duty order on seamless refined copper pipe and tube from Mexico, covering the period November 22, 2010, to April 30, 2011. See Seamless Refined Copper Pipe and Tube From Mexico: Notice of Initiation of...

Seamless Collapsible Fuel Tanks. Phase 1

DTIC Science & Technology

1982-03-01

TITLE (and Subtitle) 5. TYrE OF REPORT & PERIOD COVERED Final Report: Phase I Seamless Collapsible Fuel Tanks April 1980 - March 1982 6. PERFORMING...KEY WORDS (Continue on reverse side it neceessery nd identify by block number) tubular weaving, pillow tanks, fuel resistance , water resistance ...ends x 28 picks per inch in a plain or basket weave. The fabric is then coated both sides with an appropriate fuel- resistant compound, usually a nitrile

Method and apparatus for an optical function generator for seamless tiled displays

NASA Technical Reports Server (NTRS)

Johnson, Michael (Inventor); Chen, Chung-Jen (Inventor)

2004-01-01

Producing seamless tiled images from multiple displays includes measuring a luminance profile of each of the displays, computing a desired luminance profile for each of the displays, and determining a spatial gradient profile of each of the displays based on the measured luminance profile and the computed desired luminance profile. The determined spatial gradient profile is applied to a spatial filter to be inserted into each of the displays to produce the seamless tiled display image.

Outcomes assessment of a pharmacist-directed seamless care program in an ambulatory oncology clinic.

PubMed

Edwards, Scott J; Abbott, Rick; Edwards, Jonathan; LeBlanc, Michael; Dranitsaris, George; Donnan, Jennifer; Laing, Kara; Whelan, Maria A; MacKinnon, Neil J

2014-02-01

The primary goal of seamless care is improved patient outcomes and improved standards of care for patients with cancer. The pharmacy service of the Newfoundland Cancer Treatment and Research Foundation conducted a randomized control study that measured clinical and humanistic outcomes of a pharmacist-directed seamless care program in an ambulatory oncology clinic. This article focuses on the intervention group, particularly the identification of drug-related problems (DRPs) and utilization of health care services as well the satisfaction of 3 types of health professionals with the services provided by the pharmacist-directed seamless care program. Overall, the seamless care pharmacist (SCP) identified an average of 3.7 DRPs per intervention patient; the most common DRP reported was a patient not receiving or taking a drug therapy for which there is an indication. The SCP identified more DRPs in patients receiving adjuvant treatment compared to those receiving palliative treatment. On average, family physicians, oncology nurses, and hospital pharmacists were satisfied with the SCP intervention indicating that they agreed the information collected and distributed by the SCP was useful to them. Pharmacist-directed seamless care services in an ambulatory oncology clinic have a significant impact on clinical outcomes and processes of patient care. The presence of a SCP can help identify and resolve DRPs experienced by patients in an outpatient oncology clinic, ensuring that patients are receiving the highest standard of care.

77 FR 21968 - Seamless Carbon and Alloy Steel Standard, Line, and Pressure Pipe From the People's Republic of...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-12

... countervailing duty order on seamless carbon and alloy steel standard, line, and pressure pipe from the People's... administrative review of the countervailing duty order on seamless carbon and alloy steel standard, line, and... Making Co., Ltd., Wuxi Seamless Special Pipe Co., Ltd., Wuxi Sifang Steel Tube Co., Ltd., Wuxi Zhenda...

20 CFR 641.861 - Must SCSEP recipients provide funding for the administrative costs of subrecipients?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Must SCSEP recipients provide funding for the... Administrative Requirements § 641.861 Must SCSEP recipients provide funding for the administrative costs of subrecipients? (a) Recipients and subrecipients must obtain funding for administrative costs to the extent...

Moving from Seemless to Seamless Pathways for Students.

ERIC Educational Resources Information Center

McClure, Glennis; Ross, Richard

In 1994, the Nebraska Articulation Planning Team (NAPT) was created to investigate opportunities for establishing horizontal and vertical articulation, curriculum integration, and staff development in the state to provide students with seamless pathways in their movement along the educational continuum. During the 1994-95 academic year, NAPT…

An Open Platform for Seamless Sensor Support in Healthcare for the Internet of Things

PubMed Central

Miranda, Jorge; Cabral, Jorge; Wagner, Stefan Rahr; Fischer Pedersen, Christian; Ravelo, Blaise; Memon, Mukhtiar; Mathiesen, Morten

2016-01-01

Population aging and increasing pressure on health systems are two issues that demand solutions. Involving and empowering citizens as active managers of their health represents a desirable shift from the current culture mainly focused on treatment of disease, to one also focused on continuous health management and well-being. Current developments in technological areas such as the Internet of Things (IoT), lead to new technological solutions that can aid this shift in the healthcare sector. This study presents the design, development, implementation and evaluation of a platform called Common Recognition and Identification Platform (CRIP), a part of the CareStore project, which aims at supporting caregivers and citizens to manage health routines in a seamless way. Specifically, the CRIP offers sensor-based support for seamless identification of users and health devices. A set of initial requirements was defined with a focus on usability limitations and current sensor technologies. The CRIP was designed and implemented using several technologies that enable seamless integration and interaction of sensors and people, namely Near Field Communication and fingerprint biometrics for identification and authentication, Bluetooth for communication with health devices and web services for wider integration with other platforms. Two CRIP prototypes were implemented and evaluated in laboratory during a period of eight months. The evaluations consisted of identifying users and devices, as well as seamlessly configure and acquire vital data from the last. Also, the entire Carestore platform was deployed in a nursing home where its usability was evaluated with caregivers. The evaluations helped assess that seamless identification of users and seamless configuration and communication with health devices is feasible and can help enable the IoT on healthcare applications. Therefore, the CRIP and similar platforms could be transformed into a valuable enabling technology for secure and

An Open Platform for Seamless Sensor Support in Healthcare for the Internet of Things.

PubMed

Miranda, Jorge; Cabral, Jorge; Wagner, Stefan Rahr; Fischer Pedersen, Christian; Ravelo, Blaise; Memon, Mukhtiar; Mathiesen, Morten

2016-12-08

Population aging and increasing pressure on health systems are two issues that demand solutions. Involving and empowering citizens as active managers of their health represents a desirable shift from the current culture mainly focused on treatment of disease, to one also focused on continuous health management and well-being. Current developments in technological areas such as the Internet of Things (IoT), lead to new technological solutions that can aid this shift in the healthcare sector. This study presents the design, development, implementation and evaluation of a platform called Common Recognition and Identification Platform (CRIP), a part of the CareStore project, which aims at supporting caregivers and citizens to manage health routines in a seamless way. Specifically, the CRIP offers sensor-based support for seamless identification of users and health devices. A set of initial requirements was defined with a focus on usability limitations and current sensor technologies. The CRIP was designed and implemented using several technologies that enable seamless integration and interaction of sensors and people, namely Near Field Communication and fingerprint biometrics for identification and authentication, Bluetooth for communication with health devices and web services for wider integration with other platforms. Two CRIP prototypes were implemented and evaluated in laboratory during a period of eight months. The evaluations consisted of identifying users and devices, as well as seamlessly configure and acquire vital data from the last. Also, the entire Carestore platform was deployed in a nursing home where its usability was evaluated with caregivers. The evaluations helped assess that seamless identification of users and seamless configuration and communication with health devices is feasible and can help enable the IoT on healthcare applications. Therefore, the CRIP and similar platforms could be transformed into a valuable enabling technology for secure and

Influence of RNA Strand Rigidity on Polyion Complex Formation with Block Catiomers.

PubMed

Hayashi, Kotaro; Chaya, Hiroyuki; Fukushima, Shigeto; Watanabe, Sumiyo; Takemoto, Hiroyasu; Osada, Kensuke; Nishiyama, Nobuhiro; Miyata, Kanjiro; Kataoka, Kazunori

2016-03-01

Polyion complexes (b-PICs) are prepared by mixing single- or double-stranded oligo RNA (aniomer) with poly(ethylene glycol)-b-poly(L-lysine) (PEG-PLL) (block catiomer) to clarify the effect of aniomer chain rigidity on association behaviors at varying concentrations. Here, a 21-mer single-stranded RNA (ssRNA) (persistence length: 1.0 nm) and a 21-mer double-stranded RNA (small interfering RNA, siRNA) (persistence length: 62 nm) are compared. Both oligo RNAs form a minimal charge-neutralized ionomer pair with a single PEG-PLL chain, termed unit b-PIC (uPIC), at low concentrations (<≈ 0.01 mg mL(-1)). Above the critical association concentration (≈ 0.01 mg mL(-1)), ssRNA b-PICs form secondary associates, PIC micelles, with sizes up to 30-70 nm, while no such multimolecular assembly is observed for siRNA b-PICs. The entropy gain associated with the formation of a segregated PIC phase in the multimolecular PIC micelles may not be large enough for rigid siRNA strands to compensate with appreciably high steric repulsion derived from PEG chains. Chain rigidity appears to be a critical parameter in polyion complex association. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

78 FR 41366 - Certain Large Diameter Carbon and Alloy Seamless Standard, Line, and Pressure Pipe (Over 4 1/2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-10

... Carbon and Alloy Seamless Standard, Line, and Pressure Pipe (Over 4 \\1/2\\ Inches) From Japan: Preliminary... seamless standard, line, and pressure pipe (over 4 \\1/2\\ inches) (large diameter seamless pipe) from Japan.../exporters of subject merchandise, Canadian Natural Resources Limited (CNRL), JFE Steel Corporation (JFE...

Seamless service: research and action.

PubMed

Grinstead, N; Timoney, R

1994-01-01

Describes the process used by the Mater Infirmorum Hospital in Belfast in 1992-1994 to achieve high quality care (Seamless Service), and motivate staff to deliver and measure performance. Aims of the project include focusing the organization on the customer, improving teamwork and motivation at all levels. After comprehensive data collection from GPs, patients and staff forums developed a full TQM strategy to gain support and maintain momentum including innovative staff events (every staff member was given the opportunity to attend) where multilevel, multidisciplinary workshops enabled staff to design customer care standards, develop teams and lead customer-driven change.

Private Graphs - Access Rights on Graphs for Seamless Navigation

NASA Astrophysics Data System (ADS)

Dorner, W.; Hau, F.; Pagany, R.

2016-06-01

After the success of GNSS (Global Navigational Satellite Systems) and navigation services for public streets, indoor seems to be the next big development in navigational services, relying on RTLS - Real Time Locating Services (e.g. WIFI) and allowing seamless navigation. In contrast to navigation and routing services on public streets, seamless navigation will cause an additional challenge: how to make routing data accessible to defined users or restrict access rights for defined areas or only to parts of the graph to a defined user group? The paper will present case studies and data from literature, where seamless and especially indoor navigation solutions are presented (hospitals, industrial complexes, building sites), but the problem of restricted access rights was only touched from a real world, but not a technical perspective. The analysis of case studies will show, that the objective of navigation and the different target groups for navigation solutions will demand well defined access rights and require solutions, how to make only parts of a graph to a user or application available to solve a navigational task. The paper will therefore introduce the concept of private graphs, which is defined as a graph for navigational purposes covering the street, road or floor network of an area behind a public street and suggest different approaches how to make graph data for navigational purposes available considering access rights and data protection, privacy and security issues as well.

Brief report: EGFR L858M/L861Q cis mutations confer selective sensitivity to afatinib

PubMed Central

Saxon, Jamie A.; Sholl, Lynette M.; Jänne, Pasi A.

2017-01-01

Introduction Tyrosine kinase inhibitors (TKIs) have been developed to treat patients with epidermal growth factor receptor (EGFR)-mutant lung cancers. However, the therapeutic efficacy of TKIs in patients with uncommon EGFR mutations remains unclear. Methods Next-generation sequencing was performed on a patient’s lung adenocarcinoma tumor sample, revealing rare combined in cis (on the same allele) EGFR mutations. Stable Ba/F3 and NIH-3T3 cell lines harboring the mutations were established to investigate the effect of first, second, and third generation EGFR TKIs on cell proliferation by MTS assay and EGFR phosphorylation by Western blotting. Results EGFR L858M/L861Q mutations in cis were detected in a non-small cell lung cancer patient’s tumor. The patient demonstrated primary resistance to erlotinib and was subsequently treated with afatinib, which caused tumor regression. In in vitro studies, first and third generation TKIs exhibited a decreased capacity to prevent EGFR phosphorylation and inhibit cell proliferation in EGFR L858M/L861Q cells compared to cells harboring the common EGFR L858R point mutation. In contrast, afatinib treatment reduced proliferation and inhibited EGFR phosphorylation in L858M/L861Q and L858R mutant cells at similar concentrations. Conclusions Afatinib may be a beneficial therapeutic option for a subset of lung cancer patients with rare EGFR mutations in their tumors. Understanding how uncommon mutations affect protein structure and TKI binding will be important for identifying effective targeted therapies for these patients. PMID:28088511

Interaction between serotonin transporter and serotonin receptor 1 B genes polymorphisms may be associated with antisocial alcoholism.

PubMed

Wang, Tzu-Yun; Lee, Sheng-Yu; Chen, Shiou-Lan; Chang, Yun-Hsuan; Chen, Shih-Heng; Chu, Chun-Hsien; Huang, San-Yuan; Tzeng, Nian-Sheng; Wang, Chen-Lin; Lee, I Hui; Yeh, Tzung Lieh; Yang, Yen Kuang; Lu, Ru-Band

2012-07-11

Several studies have hypothesized that genes regulating the components of the serotonin system, including serotonin transporter (5-HTTLPR) and serotonin 1 B receptor (5-HT1B), may be associated with alcoholism, but their results are contradictory because of alcoholism's heterogeneity. Therefore, we examined whether the 5-HTTLPR gene and 5-HT1B gene G861C polymorphism are susceptibility factors for a specific subtype of alcoholism, antisocial alcoholism in Han Chinese in Taiwan. We recruited 273 Han Chinese male inmates with antisocial personality disorder (ASPD) [antisocial alcoholism (AS-ALC) group (n=120) and antisocial non-alcoholism (AS-N-ALC) group (n=153)] and 191 healthy male controls from the community. Genotyping was done using PCR-RFLP. There were no significant differences in the genotypic frequency of the 5-HT1B G861C polymorphism between the 3 groups. Although AS-ALC group members more frequently carried the 5-HTTLPR S/S, S/LG, and LG/LG genotypes than controls, the difference became non-significant after controlling for the covarying effects of age. However, the 5-HTTLPR S/S, S/LG, and LG/LG genotypes may have interacted with the 5-HT1B G861C C/C polymorphism and increased the risk of becoming antisocial alcoholism. Our study suggests that neither the 5-HTTLPR gene nor the 5-HT1B G861C polymorphism alone is a risk factor for antisocial alcoholism in Taiwan's Han Chinese population, but that the interaction between both genes may increase susceptibility to antisocial alcoholism.

Service life evaluation of rigid explosive transfer lines

NASA Technical Reports Server (NTRS)

Bement, L. J.; Kayser, E. G.; Schimmel, M. L.

1983-01-01

This paper describes a joint Army/NASA-sponsored research program on the service life evaluation of rigid explosive transfer lines. These transfer lines are used to initiate emergency crew escape functions on a wide variety of military and NASA aircraft. The purpose of this program was to determine quantitatively the effects of service, age, and degradation on rigid explosive transfer lines to allow responsible, conservative, service life determination. More than 800 transfer lines were removed from the U.S. Army AH-1G and AH-1S, the U.S. Air Force B-1 and F-111, and the U.S. Navy F-14 aircraft for testing. The results indicated that the lines were not adversely affected by age, service, or a repeat of the thermal qualification tests on full-service lines. Extension of the service life of rigid explosive transfer lines should be considered, since considerable cost savings could be realized with no measurable decrease in system reliability.

75 FR 69050 - Certain Seamless Carbon and Alloy Steel Standard, Line, and Pressure Pipe From the People's...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-10

...''), the Department is issuing a countervailing duty order on certain seamless carbon and alloy steel... circumstances do not exist. See Certain Seamless Carbon and Alloy Steel Standard, Line, [[Page 69051

Buckling Response of a Large-Scale, Seamless, Orthogrid-Stiffened Metallic Cylinder

NASA Technical Reports Server (NTRS)

Rudd, Michelle Tillotson; Hilburger, Mark W.; Lovejoy, Andrew E.; Lindell, Michael C.; Gardner, Nathaniel W.; Schultz, Marc R.

2018-01-01

Results from the buckling test of a compression-loaded 8-ft-diameter seamless (i.e., without manufacturing joints), orthogrid-stiffened metallic cylinder are presented. This test was used to assess the buckling response and imperfection sensitivity characteristics of a seamless cylinder. In addition, the test article and test served as a technology demonstration to show the application of the flow forming manufacturing process to build more efficient buckling-critical structures by eliminating the welded joints that are traditionally used in the manufacturing of large metallic barrels. Pretest predictions of the cylinder buckling response were obtained using a finite-element model that included measured geometric imperfections. The buckling load predicted using this model was 697,000 lb, and the test article buckled at 743,000 lb (6% higher). After the test, the model was revised to account for measured variations in skin and stiffener geometry, nonuniform loading, and material properties. The revised model predicted a buckling load of 754,000 lb, which is within 1.5% of the tested buckling load. In addition, it was determined that the load carrying capability of the seamless cylinder is approximately 28% greater than a corresponding cylinder with welded joints.

Quasi-Continuum Reduction of Field Theories: A Route to Seamlessly Bridge Quantum and Atomistic Length-Scales with Continuum

DTIC Science & Technology

2016-04-01

AFRL-AFOSR-VA-TR-2016-0145 Quasi-continuum reduction of field theories: A route to seamlessly bridge quantum and atomistic length-scales with...field theories: A route to seamlessly bridge quantum and atomistic length-scales with continuum Principal Investigator: Vikram Gavini Department of...calculations on tens of thousands of atoms, and enable continuing efforts towards a seamless bridging of the quantum and continuum length-scales

Enhanced enzyme kinetic stability by increasing rigidity within the active site.

PubMed

Xie, Yuan; An, Jiao; Yang, Guangyu; Wu, Geng; Zhang, Yong; Cui, Li; Feng, Yan

2014-03-14

Enzyme stability is an important issue for protein engineers. Understanding how rigidity in the active site affects protein kinetic stability will provide new insight into enzyme stabilization. In this study, we demonstrated enhanced kinetic stability of Candida antarctica lipase B (CalB) by mutating the structurally flexible residues within the active site. Six residues within 10 Å of the catalytic Ser(105) residue with a high B factor were selected for iterative saturation mutagenesis. After screening 2200 colonies, we obtained the D223G/L278M mutant, which exhibited a 13-fold increase in half-life at 48 °C and a 12 °C higher T50(15), the temperature at which enzyme activity is reduced to 50% after a 15-min heat treatment. Further characterization showed that global unfolding resistance against both thermal and chemical denaturation also improved. Analysis of the crystal structures of wild-type CalB and the D223G/L278M mutant revealed that the latter formed an extra main chain hydrogen bond network with seven structurally coupled residues within the flexible α10 helix that are primarily involved in forming the active site. Further investigation of the relative B factor profile and molecular dynamics simulation confirmed that the enhanced rigidity decreased fluctuation of the active site residues at high temperature. These results indicate that enhancing the rigidity of the flexible segment within the active site may provide an efficient method for improving enzyme kinetic stability.

Seamless Image Mosaicking via Synchronization

NASA Astrophysics Data System (ADS)

Santellani, E.; Maset, E.; Fusiello, A.

2018-05-01

This paper proposes an innovative method to create high-quality seamless planar mosaics. The developed pipeline ensures good robustness against many common mosaicking problems (e.g., misalignments, colour distortion, moving objects, parallax) and differs from other works in the literature because a global approach, known as synchronization, is used for image registration and colour correction. To better conceal the mosaic seamlines, images are cut along specific paths, computed using a Voronoi decomposition of the mosaic area and a shortest path algorithm. Results obtained on challenging real datasets show that the colour correction mitigates significantly the colour variations between the original images and the seams on the final mosaic are not evident.

EGFR and HER2 activate rigidity sensing only on rigid matrices

NASA Astrophysics Data System (ADS)

Saxena, Mayur; Liu, Shuaimin; Yang, Bo; Hajal, Cynthia; Changede, Rishita; Hu, Junqiang; Wolfenson, Haguy; Hone, James; Sheetz, Michael P.

2017-07-01

Epidermal growth factor receptor (EGFR) interacts with integrins during cell spreading and motility, but little is known about the role of EGFR in these mechanosensing processes. Here we show, using two different cell lines, that in serum- and EGF-free conditions, EGFR or HER2 activity increase spreading and rigidity-sensing contractions on rigid, but not soft, substrates. Contractions peak after 15-20 min, but diminish by tenfold after 4 h. Addition of EGF at that point increases spreading and contractions, but this can be blocked by myosin-II inhibition. We further show that EGFR and HER2 are activated through phosphorylation by Src family kinases (SFK). On soft surfaces, neither EGFR inhibition nor EGF stimulation have any effect on cell motility. Thus, EGFR or HER2 can catalyse rigidity sensing after associating with nascent adhesions under rigidity-dependent tension downstream of SFK activity. This has broad implications for the roles of EGFR and HER2 in the absence of EGF both for normal and cancerous growth.

26 CFR 1.861-11 - Special rules for allocating and apportioning interest expense of an affiliated group of...

Code of Federal Regulations, 2010 CFR

2010-04-01

... group as one or more chains of includible corporations connected through 80-percent stock ownership with... indirect ownership under § 1.861-11T(d)(6). The Commissioner shall have the authority to disregard trusts...

Seamless Language Learning: Second Language Learning with Social Media

ERIC Educational Resources Information Center

Wong, Lung-Hsiang; Chai, Ching Sing; Aw, Guat Poh

2017-01-01

This conceptual paper describes a language learning model that applies social media to foster contextualized and connected language learning in communities. The model emphasizes weaving together different forms of language learning activities that take place in different learning contexts to achieve seamless language learning. it promotes social…

Interaction between Serotonin Transporter and Serotonin Receptor 1 B genes polymorphisms may be associated with antisocial alcoholism

PubMed Central

2012-01-01

Background Several studies have hypothesized that genes regulating the components of the serotonin system, including serotonin transporter (5-HTTLPR) and serotonin 1 B receptor (5-HT1B), may be associated with alcoholism, but their results are contradictory because of alcoholism’s heterogeneity. Therefore, we examined whether the 5-HTTLPR gene and 5-HT1B gene G861C polymorphism are susceptibility factors for a specific subtype of alcoholism, antisocial alcoholism in Han Chinese in Taiwan. Methods We recruited 273 Han Chinese male inmates with antisocial personality disorder (ASPD) [antisocial alcoholism (AS-ALC) group (n = 120) and antisocial non-alcoholism (AS-N-ALC) group (n = 153)] and 191 healthy male controls from the community. Genotyping was done using PCR-RFLP. Results There were no significant differences in the genotypic frequency of the 5-HT1B G861C polymorphism between the 3 groups. Although AS-ALC group members more frequently carried the 5-HTTLPR S/S, S/LG, and LG/LG genotypes than controls, the difference became non-significant after controlling for the covarying effects of age. However, the 5-HTTLPR S/S, S/LG, and LG/LG genotypes may have interacted with the 5-HT1B G861C C/C polymorphism and increased the risk of becoming antisocial alcoholism. Conclusion Our study suggests that neither the 5-HTTLPR gene nor the 5-HT1B G861C polymorphism alone is a risk factor for antisocial alcoholism in Taiwan’s Han Chinese population, but that the interaction between both genes may increase susceptibility to antisocial alcoholism. PMID:22550993

21 CFR 172.861 - Cocoa butter substitute from coconut oil, palm kernel oil, or both oils.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 3 2014-04-01 2014-04-01 false Cocoa butter substitute from coconut oil, palm... HUMAN CONSUMPTION Multipurpose Additives § 172.861 Cocoa butter substitute from coconut oil, palm kernel oil, or both oils. The food additive, cocoa butter substitute from coconut oil, palm kernel oil, or...

76 FR 60083 - Carbon and Alloy Seamless Standard, Line, and Pressure Pipe From Japan and Romania

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-28

... Alloy Seamless Standard, Line, and Pressure Pipe From Japan and Romania Determinations On the basis of... pressure pipe from Japan and Romania would be likely to lead to continuation or recurrence of material... Seamless Standard, Line, and Pressure Pipe from Japan and Romania: Investigation Nos. 731-TA-847 and 849...

Rotary roller of no. 2 seamless line in bays 19 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Rotary roller of no. 2 seamless line in bays 19 and 20 of the main pipe mill building looking north. - U.S. Steel National Tube Works, Main Pipe Mill Building, Along Monongahela River, McKeesport, Allegheny County, PA

Taylorwilson four roll straightener of the no. 1 seamless line ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Taylor-wilson four roll straightener of the no. 1 seamless line in bay 12 of the main pipe mill building. - U.S. Steel National Tube Works, Main Pipe Mill Building, Along Monongahela River, McKeesport, Allegheny County, PA

EGFR and HER2 Activate Rigidity Sensing Only on Rigid Matrices

PubMed Central

Saxena, Mayur; Liu, Shuaimin; Yang, Bo; Hajal, Cynthia; Changede, Rishita; Hu, Junqiang

2017-01-01

Epidermal growth factor receptor (EGFR) interacts with integrins during cell spreading and motility, but little is known about the role of EGFR in these mechanosensing processes. Here we show, using two different cell lines, that in serum- and EGF-free conditions, EGFR or HER2 activity increase spreading and rigidity-sensing contractions on rigid, but not soft, substrates. Contractions peak after 15–20 min, but diminish by 10-fold after 4 hours. Addition of EGF at that point increases spreading and contractions, but this can be blocked by myosin-II inhibition. We further show that EGFR and HER2 are activated through phosphorylation by Src family kinases (SFK). On soft surfaces, neither EGFR inhibition nor EGF stimulation have any effect on cell motility. Thus, EGFR or HER2 can catalyse rigidity sensing after associating with nascent adhesions under rigidity-dependent tension downstream of SFK activity. This has broad implications for the roles of EGFR and HER2 in absence of EGF both for normal and cancerous growth. PMID:28459445

Rigidly foldable origami gadgets and tessellations

PubMed Central

Evans, Thomas A.; Lang, Robert J.; Magleby, Spencer P.; Howell, Larry L.

2015-01-01

Rigidly foldable origami allows for motion where all deflection occurs at the crease lines and facilitates the application of origami in materials other than paper. In this paper, we use a recently discovered method for determining rigid foldability to identify existing flat-foldable rigidly foldable tessellations, which are also categorized. We introduce rigidly foldable origami gadgets which may be used to modify existing tessellations or to create new tessellations. Several modified and new rigidly foldable tessellations are presented. PMID:26473037

Torsional Stability of Aluminum Alloy Seamless Tubing

NASA Technical Reports Server (NTRS)

Moore, R L; Paul, D A

1939-01-01

Torsion tests were made on 51ST aluminum-alloy seamless tubes having diameter-to-thickness ratios of from 77 to 139 and length-to-diameter ratios of from 1 to 60. The torsional strengths developed in the tubes which failed elastically (all tubes having lengths greater than 2 to 6 times the diameter) were in most cases within 10 percent of the value indicated by the theories of Donnel, Timoshenko, and Sturm, assuming a condition of simply supported ends.

Rotary roller mandrel of no. 2 seamless line in bays ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Rotary roller mandrel of no. 2 seamless line in bays 19 and 20 of the main pipe mill building looking south. - U.S. Steel National Tube Works, Main Pipe Mill Building, Along Monongahela River, McKeesport, Allegheny County, PA

Global Data Spatially Interrelate System for Scientific Big Data Spatial-Seamless Sharing

NASA Astrophysics Data System (ADS)

Yu, J.; Wu, L.; Yang, Y.; Lei, X.; He, W.

2014-04-01

A good data sharing system with spatial-seamless services will prevent the scientists from tedious, boring, and time consuming work of spatial transformation, and hence encourage the usage of the scientific data, and increase the scientific innovation. Having been adopted as the framework of Earth datasets by Group on Earth Observation (GEO), Earth System Spatial Grid (ESSG) is potential to be the spatial reference of the Earth datasets. Based on the implementation of ESSG, SDOG-ESSG, a data sharing system named global data spatially interrelate system (GASE) was design to make the data sharing spatial-seamless. The architecture of GASE was introduced. The implementation of the two key components, V-Pools, and interrelating engine, and the prototype is presented. Any dataset is firstly resampled into SDOG-ESSG, and is divided into small blocks, and then are mapped into hierarchical system of the distributed file system in V-Pools, which together makes the data serving at a uniform spatial reference and at a high efficiency. Besides, the datasets from different data centres are interrelated by the interrelating engine at the uniform spatial reference of SDOGESSG, which enables the system to sharing the open datasets in the internet spatial-seamless.

75 FR 11119 - Certain Large Diameter Carbon and Alloy Seamless Standard, Line, and Pressure Pipe From Japan...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-10

... Carbon and Alloy Seamless Standard, Line, and Pressure Pipe From Japan: Extension of Time Limit for... review of the antidumping duty order on certain large diameter carbon and alloy seamless standard, line... manufacturers/exporters: JFE Steel Corporation; Nippon Steel Corporation; NKK Tubes; and Sumitomo Metal...

Toward seamless hydrologic predictions across spatial scales

NASA Astrophysics Data System (ADS)

Samaniego, Luis; Kumar, Rohini; Thober, Stephan; Rakovec, Oldrich; Zink, Matthias; Wanders, Niko; Eisner, Stephanie; Müller Schmied, Hannes; Sutanudjaja, Edwin H.; Warrach-Sagi, Kirsten; Attinger, Sabine

2017-09-01

Land surface and hydrologic models (LSMs/HMs) are used at diverse spatial resolutions ranging from catchment-scale (1-10 km) to global-scale (over 50 km) applications. Applying the same model structure at different spatial scales requires that the model estimates similar fluxes independent of the chosen resolution, i.e., fulfills a flux-matching condition across scales. An analysis of state-of-the-art LSMs and HMs reveals that most do not have consistent hydrologic parameter fields. Multiple experiments with the mHM, Noah-MP, PCR-GLOBWB, and WaterGAP models demonstrate the pitfalls of deficient parameterization practices currently used in most operational models, which are insufficient to satisfy the flux-matching condition. These examples demonstrate that J. Dooge's 1982 statement on the unsolved problem of parameterization in these models remains true. Based on a review of existing parameter regionalization techniques, we postulate that the multiscale parameter regionalization (MPR) technique offers a practical and robust method that provides consistent (seamless) parameter and flux fields across scales. Herein, we develop a general model protocol to describe how MPR can be applied to a particular model and present an example application using the PCR-GLOBWB model. Finally, we discuss potential advantages and limitations of MPR in obtaining the seamless prediction of hydrological fluxes and states across spatial scales.

21 CFR 164.120 - Shelled nuts in rigid or semirigid containers.

Code of Federal Regulations, 2010 CFR

2010-04-01

... SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION TREE NUT AND PEANUT PRODUCTS Requirements for Specific Standardized Tree Nut and Peanut Products § 164.120 Shelled nuts in rigid or semirigid containers. (a)-(b...

21 CFR 164.120 - Shelled nuts in rigid or semirigid containers.

Code of Federal Regulations, 2013 CFR

2013-04-01

... SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION TREE NUT AND PEANUT PRODUCTS Requirements for Specific Standardized Tree Nut and Peanut Products § 164.120 Shelled nuts in rigid or semirigid containers. (a)-(b...

21 CFR 164.120 - Shelled nuts in rigid or semirigid containers.

Code of Federal Regulations, 2012 CFR

2012-04-01

... SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION TREE NUT AND PEANUT PRODUCTS Requirements for Specific Standardized Tree Nut and Peanut Products § 164.120 Shelled nuts in rigid or semirigid containers. (a)-(b...

21 CFR 164.120 - Shelled nuts in rigid or semirigid containers.

Code of Federal Regulations, 2014 CFR

2014-04-01

... SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION TREE NUT AND PEANUT PRODUCTS Requirements for Specific Standardized Tree Nut and Peanut Products § 164.120 Shelled nuts in rigid or semirigid containers. (a)-(b...

21 CFR 164.120 - Shelled nuts in rigid or semirigid containers.

Code of Federal Regulations, 2011 CFR

2011-04-01

... SERVICES (CONTINUED) FOOD FOR HUMAN CONSUMPTION TREE NUT AND PEANUT PRODUCTS Requirements for Specific Standardized Tree Nut and Peanut Products § 164.120 Shelled nuts in rigid or semirigid containers. (a)-(b...

Mobile-Assisted Seamless Learning Activities in Higher Distance Education

ERIC Educational Resources Information Center

Amhag, Lisbeth

2017-01-01

Among online learning factors stated in the research literature, it is argued that online activities is the strongest factor which contributes to online learning. This article illuminates mobile-assisted seamless learning activities by using laptops, tablets, or smart phones. Two conditions are compared, a) face-to-face (F2F) online webinars…

Towards seamless workflows in agile data science

NASA Astrophysics Data System (ADS)

Klump, J. F.; Robertson, J.

2017-12-01

Agile workflows are a response to projects with requirements that may change over time. They prioritise rapid and flexible responses to change, preferring to adapt to changes in requirements rather than predict them before a project starts. This suits the needs of research very well because research is inherently agile in its methodology. The adoption of agile methods has made collaborative data analysis much easier in a research environment fragmented across institutional data stores, HPC, personal and lab computers and more recently cloud environments. Agile workflows use tools that share a common worldview: in an agile environment, there may be more that one valid version of data, code or environment in play at any given time. All of these versions need references and identifiers. For example, a team of developers following the git-flow conventions (github.com/nvie/gitflow) may have several active branches, one for each strand of development. These workflows allow rapid and parallel iteration while maintaining identifiers pointing to individual snapshots of data and code and allowing rapid switching between strands. In contrast, the current focus of versioning in research data management is geared towards managing data for reproducibility and long-term preservation of the record of science. While both are important goals in the persistent curation domain of the institutional research data infrastructure, current tools emphasise planning over adaptation and can introduce unwanted rigidity by insisting on a single valid version or point of truth. In the collaborative curation domain of a research project, things are more fluid. However, there is no equivalent to the "versioning iso-surface" of the git protocol for the management and versioning of research data. At CSIRO we are developing concepts and tools for the agile management of software code and research data for virtual research environments, based on our experiences of actual data analytics projects in the

75 FR 8677 - Seamless Refined Copper Pipe and Tube From the People's Republic of China and Mexico...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

... Copper Pipe and Tube From the People's Republic of China and Mexico: Postponement of Preliminary... Commerce (``the Department'') initiated the antidumping investigations of Seamless Refined Copper Pipe and Tube from the People's Republic of China and Mexico. See Seamless Refined Copper Pipe and Tube from the...

Rigid ventilation bronchoscopy under general anesthesia for treatment of pediatric pulmonary atelectasis caused by pneumonia: A review of 33 cases.

PubMed

Wu, Kuo-Hwa; Lin, Chih-Fu; Huang, Chun-Jen; Chen, Chien-Chuan

2006-01-01

Pediatric pulmonary atelectasis caused by pneumonia is a common disease. If the mucus plugs or secretions occlude the bronchial trees and cannot be cleaned by coughing, suctioning, or vigorous respiratory and physical therapy, is rigid ventilation bronchoscopy (V-B) effective and safe as a therapeutic procedure in such patients? We collected 33 cases of pediatric pulmonary atelectasis that were treated by rigid V-B under general anesthesia for removal of the mucus plugs or foreign bodies. During the rigid V-B with lung lavage performed by experienced bronchoscopists, the oxygen saturation was maintained in good condition. No disastrous complications were noted. Sixty-four percent (21/33) of those with pediatric pulmonary atelectasis had significant improvement in either oxygen saturation or chest radiography within 72 hours. We conclude that when the traditional treatment in pediatric pulmonary atelectasis was ineffective, rigid V-B might be an adequate and safe procedure to remove the mucus plugs and restore pulmonary function.

Towards accurate modeling of noncovalent interactions for protein rigidity analysis.

PubMed

Fox, Naomi; Streinu, Ileana

2013-01-01

Protein rigidity analysis is an efficient computational method for extracting flexibility information from static, X-ray crystallography protein data. Atoms and bonds are modeled as a mechanical structure and analyzed with a fast graph-based algorithm, producing a decomposition of the flexible molecule into interconnected rigid clusters. The result depends critically on noncovalent atomic interactions, primarily on how hydrogen bonds and hydrophobic interactions are computed and modeled. Ongoing research points to the stringent need for benchmarking rigidity analysis software systems, towards the goal of increasing their accuracy and validating their results, either against each other and against biologically relevant (functional) parameters. We propose two new methods for modeling hydrogen bonds and hydrophobic interactions that more accurately reflect a mechanical model, without being computationally more intensive. We evaluate them using a novel scoring method, based on the B-cubed score from the information retrieval literature, which measures how well two cluster decompositions match. To evaluate the modeling accuracy of KINARI, our pebble-game rigidity analysis system, we use a benchmark data set of 20 proteins, each with multiple distinct conformations deposited in the Protein Data Bank. Cluster decompositions for them were previously determined with the RigidFinder method from Gerstein's lab and validated against experimental data. When KINARI's default tuning parameters are used, an improvement of the B-cubed score over a crude baseline is observed in 30% of this data. With our new modeling options, improvements were observed in over 70% of the proteins in this data set. We investigate the sensitivity of the cluster decomposition score with case studies on pyruvate phosphate dikinase and calmodulin. To substantially improve the accuracy of protein rigidity analysis systems, thorough benchmarking must be performed on all current systems and future

Towards accurate modeling of noncovalent interactions for protein rigidity analysis

PubMed Central

2013-01-01

Background Protein rigidity analysis is an efficient computational method for extracting flexibility information from static, X-ray crystallography protein data. Atoms and bonds are modeled as a mechanical structure and analyzed with a fast graph-based algorithm, producing a decomposition of the flexible molecule into interconnected rigid clusters. The result depends critically on noncovalent atomic interactions, primarily on how hydrogen bonds and hydrophobic interactions are computed and modeled. Ongoing research points to the stringent need for benchmarking rigidity analysis software systems, towards the goal of increasing their accuracy and validating their results, either against each other and against biologically relevant (functional) parameters. We propose two new methods for modeling hydrogen bonds and hydrophobic interactions that more accurately reflect a mechanical model, without being computationally more intensive. We evaluate them using a novel scoring method, based on the B-cubed score from the information retrieval literature, which measures how well two cluster decompositions match. Results To evaluate the modeling accuracy of KINARI, our pebble-game rigidity analysis system, we use a benchmark data set of 20 proteins, each with multiple distinct conformations deposited in the Protein Data Bank. Cluster decompositions for them were previously determined with the RigidFinder method from Gerstein's lab and validated against experimental data. When KINARI's default tuning parameters are used, an improvement of the B-cubed score over a crude baseline is observed in 30% of this data. With our new modeling options, improvements were observed in over 70% of the proteins in this data set. We investigate the sensitivity of the cluster decomposition score with case studies on pyruvate phosphate dikinase and calmodulin. Conclusion To substantially improve the accuracy of protein rigidity analysis systems, thorough benchmarking must be performed on all

Seamless tiled display system

NASA Technical Reports Server (NTRS)

Dubin, Matthew B. (Inventor); Larson, Brent D. (Inventor); Kolosowsky, Aleksandra (Inventor)

2006-01-01

A modular and scalable seamless tiled display apparatus includes multiple display devices, a screen, and multiple lens assemblies. Each display device is subdivided into multiple sections, and each section is configured to display a sectional image. One of the lens assemblies is optically coupled to each of the sections of each of the display devices to project the sectional image displayed on that section onto the screen. The multiple lens assemblies are configured to merge the projected sectional images to form a single tiled image. The projected sectional images may be merged on the screen by magnifying and shifting the images in an appropriate manner. The magnification and shifting of these images eliminates any visual effect on the tiled display that may result from dead-band regions defined between each pair of adjacent sections on each display device, and due to gaps between multiple display devices.

Tile-based rigidization surface parametric design study

NASA Astrophysics Data System (ADS)

Giner Munoz, Laura; Luntz, Jonathan; Brei, Diann; Kim, Wonhee

2018-03-01

Inflatable technologies have proven useful in consumer goods as well as in more recent applications including civil structures, aerospace, medical, and robotics. However, inflatable technologies are typically lacking in their ability to provide rigid structural support. Particle jamming improves upon this by providing structures which are normally flexible and moldable but become rigid when air is removed. Because these are based on an airtight bladder filled with loose particles, they always occupy the full volume of its rigid state, even when not rigidized. More recent developments in layer jamming have created thin, compact rigidizing surfaces replacing the loose volume of particles with thinly layered surface materials. Work in this area has been applied to several specific applications with positive results but have not generally provided the broader understanding of the rigidization performance as a function of design parameters required for directly adapting layer rigidization technology to other applications. This paper presents a parametric design study of a new layer jamming vacuum rigidization architecture: tile-based vacuum rigidization. This form of rigidization is based on layers of tiles contained within a thin vacuum bladder which can be bent, rolled, or otherwise compactly stowed, but when deployed flat, can be vacuumed and form a large, flat, rigid plate capable of supporting large forces both localized and distributed over the surface. The general architecture and operation detailing rigidization and compliance mechanisms is introduced. To quantitatively characterize the rigidization behavior, prototypes rigidization surfaces are fabricated and an experimental technique is developed based on a 3-point bending test. Performance evaluation metrics are developed to describe the stiffness, load-bearing capacity, and internal slippage of tested prototypes. A set of experimental parametric studies are performed to better understand the impact of

76 FR 47555 - Certain Large Diameter Carbon and Alloy Seamless Standard, Line and Pressure Pipe From Japan...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-05

... diameter seamless pipe is used primarily for line applications such as oil, gas, or water pipeline, or utility distribution systems. Seamless pressure pipes are intended for the conveyance of water, steam... Engineers (``ASME'') code stress levels. Alloy pipes made to ASTM A-335 standard must be used if...

High Resolution Seamless Dom Generation Over CHANG'E-5 Landing Area Using Lroc Nac Images

NASA Astrophysics Data System (ADS)

Di, K.; Jia, M.; Xin, X.; Liu, B.; Liu, Z.; Peng, M.; Yue, Z.

2018-04-01

Chang'e-5, China's first sample return lunar mission, will be launched in 2019, and the planned landing area is near Mons Rümker in Oceanus Procellarum. High-resolution and high-precision mapping of the landing area is of great importance for supporting scientific analysis and safe landing. This paper proposes a systematic method for large area seamless digital orthophoto map (DOM) generation, and presents the mapping result of Chang'e-5 landing area using over 700 LROC NAC images. The developed method mainly consists of two stages of data processing: stage 1 includes subarea block adjustment with rational function model (RFM) and seamless subarea DOM generation; stage 2 includes whole area adjustment through registration of the subarea DOMs with thin plate spline model and seamless DOM mosaicking. The resultant seamless DOM coves a large area (20° longitude × 4° latitude) and is tied to the widely used reference DEM - SLDEM2015. As a result, the RMS errors of the tie points are all around half pixel in image space, indicating a high internal precision; the RMS errors of the control points are about one grid cell size of SLDEM2015, indicating that the resultant DOM is tied to SLDEM2015 well.

77 FR 21734 - Certain Small Diameter Carbon and Alloy Seamless Standard, Line, and Pressure Pipe From Romania...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-11

... Carbon and Alloy Seamless Standard, Line, and Pressure Pipe From Romania: Extension of Time Limit for... diameter carbon and alloy seamless standard, line and pressure pipe from Romania for the period August 1... investigation based upon the allegation of the petitioner, U.S. Steel. See the memorandum to Susan Kuhbach dated...

77 FR 46385 - Certain Small Diameter Seamless Carbon and Alloy Standard, Line, and Pressure Pipe From Germany...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-03

...: Seamless pressure pipes are intended for the conveyance of water, steam, petrochemicals, chemicals, oil... Mechanical Engineers (ASME) code stress levels. Alloy pipes made to ASTM standard A-335 must be used if temperatures and stress levels exceed those allowed for A-106 and the ASME codes. Seamless pressure pipes sold...

78 FR 25253 - Seamless Carbon and Alloy Steel Standard, Line, and Pressure From the People's Republic of China...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-30

... administrative review of the countervailing duty order on certain seamless carbon and alloy steel standard, line... DEPARTMENT OF COMMERCE International Trade Administration [C-570-957] Seamless Carbon and Alloy Steel Standard, Line, and Pressure From the People's Republic of China: Rescission of Countervailing...

Undergraduate Certificate in Leadership Studies: An Opportunity for Seamless Learning

ERIC Educational Resources Information Center

Guthrie, Kathy L.; Bovio, Becka

2014-01-01

In working to develop undergraduate student leadership capacity, Florida State University created the Undergraduate Certificate in Leadership Studies. This program, grounded in leadership theory and framed by a seamless learning model, has been influential in development of student leadership perceptions and capacity. This article addresses the…

77 FR 59374 - Certain Small Diameter Carbon and Alloy Seamless Standard, Line and Pressure Pipe (Under 41/2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-27

... DEPARTMENT OF COMMERCE International Trade Administration [A-588-851] Certain Small Diameter Carbon and Alloy Seamless Standard, Line and Pressure Pipe (Under 4\\1/2\\ Inches) From Japan: Rescission... antidumping order on certain small diameter carbon and alloy seamless standard, line and pressure pipe (under...

CHEMICAL RIGIDIZATION OF EXPANDABLE STRUCTURES.

DTIC Science & Technology

The objective of this program was to develop a chemical rigidization process that could be activated by an on-command mechanism and be capable of...and rigidized in the high vacuum facilities atWright-Patterson AFB, Ohio and were delivered to the Air Force. A fail-safe chemical rigidization system...have been varied from fifteen minutes to two hours. The chemical system, a vinyl-type monomer, has exhibited a sustained shelf-life, under ambient

76 FR 7815 - Certain Large Diameter Carbon and Alloy Seamless Standard, Line, and Pressure Pipe (Over 41/2

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-11

... DEPARTMENT OF COMMERCE International Trade Administration [A-588-850] Certain Large Diameter Carbon and Alloy Seamless Standard, Line, and Pressure Pipe (Over 4\\1/2\\ Inches) From Japan: Extension of... administrative review of the antidumping duty order on certain large diameter carbon and alloy seamless standard...

Rigidity of lattice domes

NASA Technical Reports Server (NTRS)

Savelyev, V. A.

1979-01-01

The means of ensuring total rigidity of lattice domes, using comparison with solid shells of 1-3 layers are discussed. Irregularities of manufacture, processing, and other factors are considered, as they relate to diminution of rigidity. The discussion uses the concepts of upper and lower critical loads on the structure in question.

Mooring and ground handling rigid airships

NASA Technical Reports Server (NTRS)

Walker, H., Jr.

1975-01-01

The problems of mooring and ground handling rigid airships are discussed. A brief history of Mooring and Ground Handling Rigid Airships from July 2, 1900 through September 1, 1939 is included. Also a brief history of ground handling developments with large U. S. Navy nonrigid airships between September 1, 1939 and August 31, 1962 is included wherein developed equipment and techniques appear applicable to future large rigid airships. Finally recommendations are made pertaining to equipment and procedures which appear desirable and feasible for future rigid airship programs.

77 FR 27428 - Certain Large Diameter Carbon and Alloy Seamless Standard, Line, and Pressure Pipe (Over 41/2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-10

... diameter seamless pipe is used primarily for line applications such as oil, gas, or water pipeline, or utility distribution systems. Seamless pressure pipes are intended for the conveyance of water, steam... (``ASME'') code stress levels. Alloy pipes made to ASTM A-335 standard must be used if temperatures and...

76 FR 66688 - Certain Large Diameter Carbon and Alloy Seamless Standard, Line, and Pressure Pipe (Over 41/2

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-27

... diameter seamless pipe is used primarily for line applications such as oil, gas, or water pipeline, or utility distribution systems. Seamless pressure pipes are intended for the conveyance of water, steam... (``ASME'') code stress levels. Alloy pipes made to ASTM A-335 standard must be used if temperatures and...

Rigid and non-rigid micro-plates: Philippines and Myanmar-Andaman case studies

NASA Astrophysics Data System (ADS)

Rangin, Claude

2016-01-01

Generally, tectonic plates are considered as rigid. Oblique plate convergence favors the development of micro-plates along the converging boundaries. The north-south-trending Philippines archipelago (here named Philippine Mobile Belt, PMB), a few hundreds kilometers wide, is one of such complex tectonic zones. We show here that it is composed of rigid rotating crustal blocks (here called platelets). In Myanmar, the northernmost tip of the Sumatra-Andaman subduction system is another complex zone made of various crustal blocks in-between convergent plates. Yet, contrary to PMB, it sustains internal deformation with platelet buckling, altogether indicative of a non-rigid behavior. Therefore, the two case studies, Philippine Mobile Belt and Myanmar-Andaman micro-plate (MAS), illustrate the complexity of micro-plate tectonics and kinematics at convergent plate boundaries.

Large-strain, rigid-to-rigid deformation of bistable electroactive polymers

NASA Astrophysics Data System (ADS)

Yu, Zhibin; Yuan, Wei; Brochu, Paul; Chen, Bin; Liu, Zhitian; Pei, Qibing

2009-11-01

Thermoplastic poly(tert-butyl acrylate) (PTBA) is reported as an electroactive polymer that is rigid at ambient conditions and turns into a dielectric elastomer above a transition temperature. In the rubbery state, a PTBA thin film can be electrically actuated to strains up to 335% in area expansion. The calculated actuation pressure is 3.2 MPa. The actuation is made bistable by cooling to below glass transition temperature. The PTBA represents the bistable electroactive polymer (BSEP) that can be actuated to various largely strained, rigid shapes. The application of the BSEP for refreshable Braille display, an active tactile display, is also demonstrated.

MnPAVE-Rigid 2.0

DOT National Transportation Integrated Search

2018-05-01

This project implemented additional features into MnPAVE-Rigid, leading to a new version of MnDOTs rigid pavement design software. The database of American Association of State Highway Transportation Officers (AASHTO) mechanistic-empirical (M-E) p...

Progress Toward Standards for the Seamless Interoperability of Broadband Satellite Communication Networks

NASA Technical Reports Server (NTRS)

Ivancic, William D.; Glover, Daniel R.; vonDeak, Thomas C.; Bhasin, Kul B.

1998-01-01

The realization of the full potential of the National Information Infrastructure (NH) and Global Information Infrastructure (GII) requires seamless interoperability of emerging satellite networks with terrestrial networks. This requires a cooperative effort between industry, academia and government agencies to develop and advocate new, satellite-friendly communication protocols and modifications to existing communication protocol standards. These groups have recently come together to actively participating in a number of standards making bodies including: the Internet Engineering Task Force (IETF), the Asynchronous Transfer Mode (ATM) Forum, the International Telecommunication Union (ITU) and the Telecommunication Industry Association MA) to ensure that issues regarding efficient use of these protocols over satellite links are not overlooked. This paper will summarize the progress made toward standards development to achieve seamless integration and accelerate the deployment of multimedia applications.

Rigidity of Glasses and Macromolecules

NASA Astrophysics Data System (ADS)

Thorpe, M. F.

1998-03-01

The simple yet powerful ideas of percolation theory have found their way into many different areas of research. In this talk we show how RIGIDITY PERCOLATION can be studied at a similar level of sophistication, using a powerful new program THE PEBBLE GAME (D. J. Jacobs and M. F. Thorpe, Phys. Rev. E) 53, 3682 (1996). that uses an integer algorithm. This program can analyse the rigidity of two and three dimensional networks containing more than one million bars and joints. We find the total number of floppy modes, and find the critical behavior as the network goes from floppy to rigid as more bars are added. We discuss the relevance of this work to network glasses, and how it relates to experiments that involve the mechanical properties like hardness and elasticity of covalent glassy networks like Ge_xAs_ySe_1-x-y and dicuss recent experiments that suggest that the rigidity transition may be first order (Xingwei Feng, W. J.Bresser and P. Boolchand, Phys. Rev. Lett 78), 4422 (1997).. This approach is also useful in macromolecules and proteins, where detailed information about the rigid domain structure can be obtained.

49 CFR 178.45 - Specification 3T seamless steel cylinder.

Code of Federal Regulations, 2011 CFR

2011-10-01

..., and service pressure. A DOT 3T cylinder is a seamless steel cylinder with a minimum water capacity of...) Wall thickness. The minimum wall thickness must be such that the wall stress at the minimum specified... the physical tests required in paragraphs (j) and (k) of this section. A wall stress of more than 90...

Rigidity-tuning conductive elastomer

NASA Astrophysics Data System (ADS)

Shan, Wanliang; Diller, Stuart; Tutcuoglu, Abbas; Majidi, Carmel

2015-06-01

We introduce a conductive propylene-based elastomer (cPBE) that rapidly and reversibly changes its mechanical rigidity when powered with electrical current. The elastomer is rigid in its natural state, with an elastic (Young’s) modulus of 175.5 MPa, and softens when electrically activated. By embedding the cPBE in an electrically insulating sheet of polydimethylsiloxane (PDMS), we create a cPBE-PDMS composite that can reversibly change its tensile modulus between 37 and 1.5 MPa. The rigidity change takes ˜6 s and is initiated when a 100 V voltage drop is applied across the two ends of the cPBE film. This magnitude of change in elastic rigidity is similar to that observed in natural skeletal muscle and catch connective tissue. We characterize the tunable load-bearing capability of the cPBE-PDMS composite with a motorized tensile test and deadweight experiment. Lastly, we demonstrate the ability to control the routing of internal forces by embedding several cPBE-PDMS ‘active tendons’ into a soft robotic pneumatic bending actuator. Selectively activating the artificial tendons controls the neutral axis and direction of bending during inflation.

A comparison of U.S. geological survey seamless elevation models with shuttle radar topography mission data

USGS Publications Warehouse

Gesch, D.; Williams, J.; Miller, W.

2001-01-01

Elevation models produced from Shuttle Radar Topography Mission (SRTM) data will be the most comprehensive, consistently processed, highest resolution topographic dataset ever produced for the Earth's land surface. Many applications that currently use elevation data will benefit from the increased availability of data with higher accuracy, quality, and resolution, especially in poorly mapped areas of the globe. SRTM data will be produced as seamless data, thereby avoiding many of the problems inherent in existing multi-source topographic databases. Serving as precursors to SRTM datasets, the U.S. Geological Survey (USGS) has produced and is distributing seamless elevation datasets that facilitate scientific use of elevation data over large areas. GTOPO30 is a global elevation model with a 30 arc-second resolution (approximately 1-kilometer). The National Elevation Dataset (NED) covers the United States at a resolution of 1 arc-second (approximately 30-meters). Due to their seamless format and broad area coverage, both GTOPO30 and NED represent an advance in the usability of elevation data, but each still includes artifacts from the highly variable source data used to produce them. The consistent source data and processing approach for SRTM data will result in elevation products that will be a significant addition to the current availability of seamless datasets, specifically for many areas outside the U.S. One application that demonstrates some advantages that may be realized with SRTM data is delineation of land surface drainage features (watersheds and stream channels). Seamless distribution of elevation data in which a user interactively specifies the area of interest and order parameters via a map server is already being successfully demonstrated with existing USGS datasets. Such an approach for distributing SRTM data is ideal for a dataset that undoubtedly will be of very high interest to the spatial data user community.

49 CFR 178.39 - Specification 3BN seamless nickel cylinders.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) Type, size and service pressure. A DOT 3BN cylinder is a seamless nickel cylinder with a water capacity (nominal) not over 125 pounds water capacity (nominal) and a service pressure at least 150 to not over 500...) Wall thickness. The wall stress may not exceed 15,000 psi. A minimum wall thickness of 0.100 inch is...

49 CFR 178.39 - Specification 3BN seamless nickel cylinders.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) Type, size and service pressure. A DOT 3BN cylinder is a seamless nickel cylinder with a water capacity (nominal) not over 125 pounds water capacity (nominal) and a service pressure at least 150 to not over 500...) Wall thickness. The wall stress may not exceed 15,000 psi. A minimum wall thickness of 0.100 inch is...

NoRMCorre: An online algorithm for piecewise rigid motion correction of calcium imaging data.

PubMed

Pnevmatikakis, Eftychios A; Giovannucci, Andrea

2017-11-01

Motion correction is a challenging pre-processing problem that arises early in the analysis pipeline of calcium imaging data sequences. The motion artifacts in two-photon microscopy recordings can be non-rigid, arising from the finite time of raster scanning and non-uniform deformations of the brain medium. We introduce an algorithm for fast Non-Rigid Motion Correction (NoRMCorre) based on template matching. NoRMCorre operates by splitting the field of view (FOV) into overlapping spatial patches along all directions. The patches are registered at a sub-pixel resolution for rigid translation against a regularly updated template. The estimated alignments are subsequently up-sampled to create a smooth motion field for each frame that can efficiently approximate non-rigid artifacts in a piecewise-rigid manner. Existing approaches either do not scale well in terms of computational performance or are targeted to non-rigid artifacts arising just from the finite speed of raster scanning, and thus cannot correct for non-rigid motion observable in datasets from a large FOV. NoRMCorre can be run in an online mode resulting in comparable to or even faster than real time motion registration of streaming data. We evaluate its performance with simple yet intuitive metrics and compare against other non-rigid registration methods on simulated data and in vivo two-photon calcium imaging datasets. Open source Matlab and Python code is also made available. The proposed method and accompanying code can be useful for solving large scale image registration problems in calcium imaging, especially in the presence of non-rigid deformations. Copyright © 2017 The Author(s). Published by Elsevier B.V. All rights reserved.

Rigid aggregates: theory and applications

NASA Astrophysics Data System (ADS)

Richardson, D. C.

2005-08-01

Numerical models employing ``perfect'' self-gravitating rubble piles that consist of monodisperse rigid spheres with configurable contact dissipation have been used to explore collisional and rotational disruption of gravitational aggregates. Applications of these simple models include numerical simulations of planetesimal evolution, asteroid family formation, tidal disruption, and binary asteroid formation. These studies may be limited by the idealized nature of the rubble pile model, since perfect identical spheres stack and shear in a very specific, possibly over-idealized way. To investigate how constituent properties affect the overall characteristics of a gravitational aggregate, particularly its failure modes, we have generalized our numerical code to model colliding, self-gravitating, rigid aggregates made up of variable-size spheres. Euler's equation of rigid-body motion in the presence of external torques are implemented, along with a self-consistent prescription for handling non-central impacts. Simple rules for sticking and breaking are also included. Preliminary results will be presented showing the failure modes of gravitational aggregates made up of smaller, rigid, non-idealized components. Applications of this new capability include more realistic aggregate models, convenient modeling of arbitrary rigid shapes for studies of the stability of orbiting companions (replacing one or both bodies with rigid aggregates eliminates expensive interparticle collisions while preserving the shape, spin, and gravity field of the bodies), and sticky particle aggregation in dense planetary rings. This material is based upon work supported by the National Aeronautics and Space Administration under Grant No. NAG511722 issued through the Office of Space Science and by the National Science Foundation under Grant No. AST0307549.

The role of rigid vs. dynamic instrumentation for stabilization of the degenerative lumbosacral spine.

PubMed

Korovessis, Panagiotis; Papazisis, Zisis; Lambiris, Elias

2002-01-01

This is a prospective comparative randomised study to compare the immediately postoperative effects of a rigid versus dynamic instrumentation for degenerative spine disease and stenosis on the standing sagittal lumbar spine alignment and to investigate if a dynamic spine system can replace the commonly used rigid systems in order to avoid the above mentioned disadvantages of rigid fixation. 15 randomly selected patients received the rigid instrumentation SCS and an equal number of randomly selected patients the dynamic TWINFLEX device for spinal stenosis associated degenerative lumbar disease. The age of the patients, who received rigid and dynamic instrumentation was 65 +/- 9 years and 62 +/- 10 years respectively. All patients had standing spine radiographs preoperatively and three months postoperatively. The parameters that were measured and compared pre- to postoperatively were: lumbar lordosis (L1-S1), total lumbar lordosis (T12-S1), sacral tilt, distal lordosis (L4-S1), intervertebral angulation, vertebral inclination and disc index. The instrumented levels in the spines that received rigid and dynamic instrumentation were 3.5 +/- 0.53 and 3 +/- 0.7 respectively. The instrumented levels from L3 to L5 were 23, the lumbosacral junction was instrumented in 3 patients of group A and in 4 patients of group B. Lumbar lordosis did not significantly change postoperatively, while total lordosis was significantly (P=0.04) increased in the patients who received the rigid instrumentation, while it was significantly (P=0.012) decreased in the group B. Intervertebral angulation of the non-instrumented level L1-L2 was increased in the group A (P=0.01), while the dynamic instrumentation increased (P=0.02) the intervertebral inclination of the adjacent level L2-L3, immediately above the uppermost instrumented level. Distal lordosis and sacral tilt did not change in any patient in both groups. Both instrumentations did not change the lateral vertebral inclination of L1 to L5

Emotional rigidity negatively impacts remission from anxiety and recovery of well-being.

PubMed

Wiltgen, Anika; Shepard, Christopher; Smith, Ryan; Fowler, J Christopher

2018-08-15

Emotional rigidity is described in clinical literature as a significant barrier to recovery; however, few there are few empirical measures of the construct. The current study had two aims: Study 1 aimed to identify latent factors that may bear on the construct of emotional rigidity while Study 2 assessed the potential impact of the latent factor(s) on anxiety remission rates and well-being. This study utilized data from 2472 adult inpatients (1176 females and 1296 males) with severe psychopathology. Study 1 utilized exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) to identify latent factors of emotional rigidity. Study 2 utilized hierarchical logistic regression analyses to assess the relationships among emotional rigidity factors and anxiety remission and well-being recovery at discharge. Study 1 yielded a two-factor solution identified in EFA was confirmed with CFA. Factor 1 consisted of neuroticism, experiential avoidance, non-acceptance of emotions, impaired goal-directed behavior, impulse control difficulties and limited access to emotion regulation strategies when experiencing negative emotions. Factor 2 consisted of lack of emotional awareness and lack of emotional clarity when experiencing negative emotions. Results of Study 2 indicated higher scores on Factor 1 was associated with lower remission rates from anxiety and poorer well-being upon discharge. Factor 2 was not predictive of outcome. Emotional rigidity appears to be a latent construct that negatively impacts remission rates from anxiety. Limitations of the present study include its retrospective design, and inefficient methods of assessing emotional rigidity. Copyright © 2018. Published by Elsevier B.V.

Bifunctional role of leucine 300 of firefly luciferase in structural rigidity.

PubMed

Yousefi, Farzad; Ataei, Farangis; Mortazavi, Mojtaba; Hosseinkhani, Saman

2017-08-01

Firefly luciferase is susceptible to thermal inactivation, thereby its intracellular half-life decreased. Previous reports indicated that L 300 R mutation (LRR mutant) in E 354 R/Arg 356 double mutant (ERR mutant) from Lampyris turkestanicus luciferase has increased its thermal stability and rigidity through induction of some ionic bonds with Asp 270 and 271. Disruption of the deduced ionic bonds in an ultra-rigid mutant of firefly luciferase did not reverse the flexibility of the protein. In this study, we investigated the effects of this residue to find the truth behind an extraordinary increase in thermal stability and rigidity of luciferase after replacement of leucine 300 by arginine based on previous reports. For this purpose, L 300 R, L 300 K and L 300 E mutations were performed to compare the effects of these mutations on the native firefly luciferase. In spite of increase of intrinsic fluorescence of the mutants a slight increase in thermostability and retention of kinetic properties was observed. Based on our results, we can conclude that L 300 R mutation in LRR mutant accompanying with alteration in a flexible loop (352-359) increased thermostability and rigidity of luciferase. Copyright © 2017 Elsevier B.V. All rights reserved.

Flexible and rigid cystoscopy in women.

PubMed

Gee, Jason R; Waterman, Bradley J; Jarrard, David F; Hedican, Sean P; Bruskewitz, Reginald C; Nakada, Stephen Y

2009-01-01

Previous studies have evaluated the tolerability of rigid versus flexible cystoscopy in men. Similar studies, however, have not been performed in women. We sought to determine whether office-based flexible cystoscopy was better tolerated than rigid cystoscopy in women. Following full IRB approval, women were prospectively randomized in a single-blind manner. Patients were randomized to flexible or rigid cystoscopy and draped in the lithotomy position to maintain blinding of the study. Questionnaires evaluated discomfort before, during, and after cystoscopy. Thirty-six women were randomized to flexible (18) or rigid (18) cystoscopy. Indications were surveillance (16), hematuria (15), recurrent UTIs (2), voiding dysfunction (1), and other (2). All questionnaires were returned by 31/36 women. Using a 10-point visual analog scale (VAS), median discomfort during the procedure for flexible and rigid cystoscopy were 1.4 and 1.8, respectively, in patients perceiving pain. Median recalled pain 1 week later was similar at 0.8 and 1.15, respectively. None of these differences were statistically significant. Flexible and rigid cystoscopy are well tolerated in women. Discomfort during and after the procedure is minimal in both groups. Urologists should perform either procedure in women based on their preference and skill level.

Origami Metamaterial based on Pattern Rigidity

NASA Astrophysics Data System (ADS)

Chen, Yan; You, Zhong

Origami inspired mechanical metamaterials are made from a tessellation of origami units. Their mechanical behaviour is closely related to the behaviour of the origami units used. In this article, we focus on a family of metamaterials that are created by the tessellation of the square twist origami units. Generally a square twist origami unit can have four distinct hill-valley crease arrangements, two of which are rigidly foldable whereas the others are not. The rigidly foldable unit has, in general, lower stiffness than that of the non-rigidly foldable one if the facets can easily rotate about the creases. We shall show that it is possible to put rigidly foldable and non-rigidly foldable units together to form a geometrically compatible tessellation, and the stiffness of the overall structure based on such a tessellation is primarily decided by the number of non-rigid units. By astutely placing such units in a tessellation, we are able to create a metamaterial with a tunable stiffness. Y Chen acknowledges the support of the NSFC (Projects 51290293 and 51422506) and the Ministry of Science and Technology of China (Project 2014DFA70710). Z You wishes to acknowledge the support of Air Force Office of Scientific Research (FA9550-16-1-0339).

Toward seamless weather-climate and environmental prediction

NASA Astrophysics Data System (ADS)

Brunet, Gilbert

2016-04-01

Over the last decade or so, predicting the weather, climate and atmospheric composition has emerged as one of the most important areas of scientific endeavor. This is partly because the remarkable increase in skill of current weather forecasts has made society more and more dependent on them day to day for a whole range of decision making. And it is partly because climate change is now widely accepted and the realization is growing rapidly that it will affect every person in the world profoundly, either directly or indirectly. One of the important endeavors of our societies is to remain at the cutting-edge of modelling and predicting the evolution of the fully coupled environmental system: atmosphere (weather and composition), oceans, land surface (physical and biological), and cryosphere. This effort will provide an increasingly accurate and reliable service across all the socio-economic sectors that are vulnerable to the effects of adverse weather and climatic conditions, whether now or in the future. This emerging challenge was at the center of the World Weather Open Science Conference (Montreal, 2014).The outcomes of the conference are described in the World Meteorological Organization (WMO) book: Seamless Prediction of the Earth System: from Minutes to Months, (G. Brunet, S. Jones, P. Ruti Eds., WMO-No. 1156, 2015). It is freely available on line at the WMO website. We will discuss some of the outcomes of the conference for the WMO World Weather Research Programme (WWRP) and Global Atmospheric Watch (GAW) long term goals and provide examples of seamless modelling and prediction across a range of timescales at convective and sub-kilometer scales for regional coupled forecasting applications at Environment and Climate Change Canada (ECCC).

Misperceptions of angular velocities influence the perception of rigidity in the kinetic depth effect

NASA Technical Reports Server (NTRS)

Domini, F.; Caudek, C.; Proffitt, D. R.; Kaiser, M. K. (Principal Investigator)

1997-01-01

Accuracy in discriminating rigid from nonrigid motion was investigated for orthographic projections of three-dimension rotating objects. In 3 experiments the hypothesis that magnitudes of angular velocity are misperceived in the kinetic depth effect was tested, and in 4 other experiments the hypothesis that misperceiving angular velocities leads to misperceiving rigidity was tested. The principal findings were (a) the magnitude of perceived angular velocity is derived heuristically as a function of a property of the first-order optic flow called deformation and (b) perceptual performance in discriminating rigid from nonrigid motion is accurate in cases when the variability of the deformations of the individual triplets of points of the stimulus displays favors this interpretation and not accurate in other cases.

Misperceptions of angular velocities influence the perception of rigidity in the kinetic depth effect.

PubMed

Domini, F; Caudek, C; Proffitt, D R

1997-08-01

Accuracy in discriminating rigid from nonrigid motion was investigated for orthographic projections of three-dimension rotating objects. In 3 experiments the hypothesis that magnitudes of angular velocity are misperceived in the kinetic depth effect was tested, and in 4 other experiments the hypothesis that misperceiving angular velocities leads to misperceiving rigidity was tested. The principal findings were (a) the magnitude of perceived angular velocity is derived heuristically as a function of a property of the first-order optic flow called deformation and (b) perceptual performance in discriminating rigid from nonrigid motion is accurate in cases when the variability of the deformations of the individual triplets of points of the stimulus displays favors this interpretation and not accurate in other cases.

Enculturating Seamless Language Learning through Artifact Creation and Social Interaction Process

ERIC Educational Resources Information Center

Wong, Lung-Hsiang; Chai, Ching Sing; Aw, Guat Poh; King, Ronnel B.

2015-01-01

This paper reports a design-based research (DBR) cycle of MyCLOUD (My Chinese ubiquitOUs learning Days). MyCLOUD is a seamless language learning model that addresses identified limitations of conventional Chinese language teaching, such as the decontextualized and unauthentic learning processes that usually hinder reflection and deep learning.…

Electrically conductive rigid polyurethane foam

DOEpatents

Neet, Thomas E.; Spieker, David A.

1985-03-19

A rigid, polyurethane foam comprises about 2-10 weight percent, based on the total foam weight, of a carbon black which is CONDUCTEX CC-40-220 or CONDUCTEX SC, whereby the rigid polyurethane foam is electrically conductive and has essentially the same mechanical properties as the same foam without carbon black added.

Electrically conductive rigid polyurethane foam

DOEpatents

Neet, T.E.; Spieker, D.A.

1983-12-08

A rigid, moldable polyurethane foam comprises about 2 to 10 weight percent, based on the total foam weight, of a carbon black which is CONDUCTEX CC-40-220 or CONDUCTEX SC, whereby the rigid polyurethane foam is electrically conductive and has essentially the same mechanical properties as the same foam without carbon black added.

Creating More Seamless Connections between University-Based Coursework and School-Based Mentoring

ERIC Educational Resources Information Center

Schuster, Dwight

2014-01-01

New accreditation standards for teacher preparation programs call for more seamless and effective connections between methods courses, clinical experiences, and school-based mentoring. Intentional clinical experiences and intermediate instructional strategies can foster collaboration between teacher preparation programs and teacher leaders in K-12…

Non-rigid, but not rigid, motion interferes with the processing of structural face information in developmental prosopagnosia.

PubMed

Maguinness, Corrina; Newell, Fiona N

2015-04-01

There is growing evidence to suggest that facial motion is an important cue for face recognition. However, it is poorly understood whether motion is integrated with facial form information or whether it provides an independent cue to identity. To provide further insight into this issue, we compared the effect of motion on face perception in two developmental prosopagnosics and age-matched controls. Participants first learned faces presented dynamically (video), or in a sequence of static images, in which rigid (viewpoint) or non-rigid (expression) changes occurred. Immediately following learning, participants were required to match a static face image to the learned face. Test face images varied by viewpoint (Experiment 1) or expression (Experiment 2) and were learned or novel face images. We found similar performance across prosopagnosics and controls in matching facial identity across changes in viewpoint when the learned face was shown moving in a rigid manner. However, non-rigid motion interfered with face matching across changes in expression in both individuals with prosopagnosia compared to the performance of control participants. In contrast, non-rigid motion did not differentially affect the matching of facial expressions across changes in identity for either prosopagnosics (Experiment 3). Our results suggest that whilst the processing of rigid motion information of a face may be preserved in developmental prosopagnosia, non-rigid motion can specifically interfere with the representation of structural face information. Taken together, these results suggest that both form and motion cues are important in face perception and that these cues are likely integrated in the representation of facial identity. Copyright © 2015 Elsevier Ltd. All rights reserved.

SPIRIT: A seamless phase I/II randomized design for immunotherapy trials.

PubMed

Guo, Beibei; Li, Daniel; Yuan, Ying

2018-06-07

Immunotherapy-treatments that enlist the immune system to battle tumors-has received widespread attention in cancer research. Due to its unique features and mechanisms for treating cancer, immunotherapy requires novel clinical trial designs. We propose a Bayesian seamless phase I/II randomized design for immunotherapy trials (SPIRIT) to find the optimal biological dose (OBD) defined in terms of the restricted mean survival time. We jointly model progression-free survival and the immune response. Progression-free survival is used as the primary endpoint to determine the OBD, and the immune response is used as an ancillary endpoint to quickly screen out futile doses. Toxicity is monitored throughout the trial. The design consists of two seamlessly connected stages. The first stage identifies a set of safe doses. The second stage adaptively randomizes patients to the safe doses identified and uses their progression-free survival and immune response to find the OBD. The simulation study shows that the SPIRIT has desirable operating characteristics and outperforms the conventional design. Copyright © 2018 John Wiley & Sons, Ltd.

Enhancement in Elastic Bending Rigidity of Polymer Loaded Reverse Microemulsions.

PubMed

Geethu, P M; Yadav, Indresh; Aswal, Vinod K; Satapathy, Dillip K

2017-11-14

Elastic bending rigidity of the surfactant shell is a crucial parameter which determines the phase behavior and stability of microemulsion droplets. For water-in-oil reverse microemulsions stabilized by AOT (sodium 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate) surfactant, the elastic bending rigidity is close to thermal energy at room temperature (k B T) and can be modified by the presence of hydrophilic polymers. Here, we explore the influence of two polymers polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP), both having nearly same size (radius of gyration, R g ) but different dipole moment, on elastic bending rigidity of water-AOT-n-decane reverse microemulsions via estimating the percolation temperatures (T P ) and droplet radii using dielectric relaxation spectroscopy (DRS) and small-angle neutron scattering (SANS) techniques. Notably, an increase in T P is observed on introducing PEG and PVP polymers and is attributed to the adsorption of polymer chains onto the surfactant monolayer. The stability of the droplet phase of microemulsion after the incorporation of PEG and PVP polymers is confirmed by contrast matching SANS experiments. An enhancement in elastic bending rigidity of AOT surfactant shell amounting to ∼46% is observed upon incorporation of PVP into the droplet core, whereas for PEG addition, a smaller increase of about 17% is recorded. We conjecture that the considerable increase in elastic bending rigidity of the surfactant monolayer upon introducing PVP is because of the strong ion-dipole interaction between anionic AOT and dipoles present along the PVP polymer chains. Scaling exponents extracted from the temperature dependent electrical conductivity measurements and the frequency dependent scaling of conductivity at percolation indicate the dynamic nature of percolation for both pure and polymer loaded reverse microemulsions. The decrease in activation energy of percolation upon incorporating PEG and PVP polymer molecules also

Seamless stitching of tile scan microscope images.

PubMed

Legesse, F B; Chernavskaia, O; Heuke, S; Bocklitz, T; Meyer, T; Popp, J; Heintzmann, R

2015-06-01

For diagnostic purposes, optical imaging techniques need to obtain high-resolution images of extended biological specimens in reasonable time. The field of view of an objective lens, however, is often smaller than the sample size. To image the whole sample, laser scanning microscopes acquire tile scans that are stitched into larger mosaics. The appearance of such image mosaics is affected by visible edge artefacts that arise from various optical aberrations which manifest in grey level jumps across tile boundaries. In this contribution, a technique for stitching tiles into a seamless mosaic is presented. The stitching algorithm operates by equilibrating neighbouring edges and forcing the brightness at corners to a common value. The corrected image mosaics appear to be free from stitching artefacts and are, therefore, suited for further image analysis procedures. The contribution presents a novel method to seamlessly stitch tiles captured by a laser scanning microscope into a large mosaic. The motivation for the work is the failure of currently existing methods for stitching nonlinear, multimodal images captured by our microscopic setups. Our method eliminates the visible edge artefacts that appear between neighbouring tiles by taking into account the overall illumination differences among tiles in such mosaics. The algorithm first corrects the nonuniform brightness that exists within each of the tiles. It then compensates for grey level differences across tile boundaries by equilibrating neighbouring edges and forcing the brightness at the corners to a common value. After these artefacts have been removed further image analysis procedures can be applied on the microscopic images. Even though the solution presented here is tailored for the aforementioned specific case, it could be easily adapted to other contexts where image tiles are assembled into mosaics such as in astronomical or satellite photos. © 2015 The Authors Journal of Microscopy © 2015 Royal

Electrostatic contribution to twist rigidity of DNA.

PubMed

Mohammad-Rafiee, Farshid; Golestanian, Ramin

2004-06-01

The electrostatic contribution to the twist rigidity of DNA is studied, and it is shown that the Coulomb self-energy of the double-helical sugar-phosphate backbone makes a considerable contribution-the electrostatic twist rigidity of DNA is found to be C(elec) approximately 5 nm, which makes up about 7% of its total twist rigidity ( C(DNA) approximately 75 nm). The electrostatic twist rigidity is found, however, to depend only weakly on the salt concentration, because of a competition between two different screening mechanisms: (1) Debye screening by the salt ions in the bulk, and (2) structural screening by the periodic charge distribution along the backbone of the helical polyelectrolyte. It is found that, depending on the parameters, the electrostatic contribution to the twist rigidity could stabilize or destabilize the structure of a helical polyelectrolyte.

Multiscale multiphysics and multidomain models—Flexibility and rigidity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xia, Kelin; Opron, Kristopher; Wei, Guo-Wei, E-mail: wei@math.msu.edu

The emerging complexity of large macromolecules has led to challenges in their full scale theoretical description and computer simulation. Multiscale multiphysics and multidomain models have been introduced to reduce the number of degrees of freedom while maintaining modeling accuracy and achieving computational efficiency. A total energy functional is constructed to put energies for polar and nonpolar solvation, chemical potential, fluid flow, molecular mechanics, and elastic dynamics on an equal footing. The variational principle is utilized to derive coupled governing equations for the above mentioned multiphysical descriptions. Among these governing equations is the Poisson-Boltzmann equation which describes continuum electrostatics with atomicmore » charges. The present work introduces the theory of continuum elasticity with atomic rigidity (CEWAR). The essence of CEWAR is to formulate the shear modulus as a continuous function of atomic rigidity. As a result, the dynamics complexity of a macromolecular system is separated from its static complexity so that the more time-consuming dynamics is handled with continuum elasticity theory, while the less time-consuming static analysis is pursued with atomic approaches. We propose a simple method, flexibility-rigidity index (FRI), to analyze macromolecular flexibility and rigidity in atomic detail. The construction of FRI relies on the fundamental assumption that protein functions, such as flexibility, rigidity, and energy, are entirely determined by the structure of the protein and its environment, although the structure is in turn determined by all the interactions. As such, the FRI measures the topological connectivity of protein atoms or residues and characterizes the geometric compactness of the protein structure. As a consequence, the FRI does not resort to the interaction Hamiltonian and bypasses matrix diagonalization, which underpins most other flexibility analysis methods. FRI's computational complexity

Fabrication of seamless calandria tubes by cold pilgering route using 3-pass and 2-pass schedules

NASA Astrophysics Data System (ADS)

Saibaba, N.

2008-12-01

Calandria tube is a large diameter, extremely thin walled zirconium alloy tube which has diameter to wall thickness ratio as high as 90-95. Such tubes are conventionally produced by the 'welded route', which involves extrusion of slabs followed by a series of hot and cold rolling passes, intermediate anneals, press forming of sheets into circular shape and closing the gap by TIG welding. Though pilgering is a well established process for the fabrication of seamless tubes, production of extremely thin walled tubes offers several challenges during pilgering. Nuclear fuel complex (NFC), Hyderabad, has successfully developed a process for the production of Zircaloy-4 calandria tubes by adopting the 'seamless route' which involves hot extrusion of mother blanks followed by three-pass pilgering or two-pass pilgering schedules. This paper deals with standardization of the seamless route processes for fabrication of calandria tubes, comparison between the tubes produced by 2-pass and 3-pass pilgering schedules, role of ultrasonic test charts for control of process parameters, development of new testing methods for burst testing and other properties.

High Temperature Properties Test and Research of 9Cr1Mo (P9) Seamless Pipe Used in Petrochemical Industry

NASA Astrophysics Data System (ADS)

Wang, Qijiang; Zhou, Yedong; Zhang, Qinglian

Production technical process of BaoSteel-produced 9Cr1Mo (P9) seamless pipe is presented, and creep property of isothermal annealed state of that steel is studied under the temperatures of 550 °C, 600 °C, 650 °C, 700 °C. Also, isothermal extrapolation method and Larson-Miller method are employed to extrapolate creep rupture strength of the steel at the creep time of 20000h, 40000h, 60000h and 100000h. The results show that high temperature properties of BaoSteel-produced 9Cr1Mo (P9) seamless pipe meets the API 530 standard of USA and the SH/T3037 standard of China's petrochemical industry, and the steel can be used in large scale petroleum cracking equipment. Meantime, the comparison of creep properties at 650 °C and transient elevated temperature properties at different temperatures between isothermal annealed state and normalized + tempered state of 9Cr1Mo (P9) seamless pipe as well as the microstructure analysis show that the normalized + tempered 9Cr1Mo (P9) seamless pipe presents better high temperature properties.

Electrochemical properties of seamless three-dimensional carbon nanotubes-grown graphene modified with horseradish peroxidase.

PubMed

Komori, Kikuo; Terse-Thakoor, Trupti; Mulchandani, Ashok

2016-10-01

Horseradish peroxidase (HRP) was immobilized through sodium dodecyl sulfate (SDS) on the surface of a seamless three-dimensional hybrid of carbon nanotubes grown at the graphene surface (HRP-SDS/CNTs/G) and its electrochemical properties were investigated. Compared with graphene alone electrode modified with HRP via SDS (HRP-SDS/G electrode), the surface coverage of electroactive HRP at the CNTs/G electrode surface was approximately 2-fold greater because of CNTs grown at the graphene surface. Based on the increase in the surface coverage of electroactive HRP, the sensitivity to H2O2 at the HRP-SDS/CNTs/G electrode was higher than that at the HRP-SDS/G electrode. The kinetics of the direct electron transfer from the CNTs/G electrode to compound I and II of modified HRP was also analyzed. Copyright © 2016 Elsevier B.V. All rights reserved.

Foreign exam management in practice: seamless access to foreign images and results in a regional environment.

PubMed

Nagels, Jason; MacDonald, David; Parker, David

2015-04-01

A challenge for many clinical users is that a patient may receive a diagnostic imaging (DI) service at a number of hospitals or private imaging clinics. The DI services that patients receive at other locations could be clinically relevant to current treatments, but typically, there is no seamless method for a clinical user to access longitudinal DI results for their patient. Radiologists, and other specialists that are intensive users of image data, require seamless ingestion of foreign exams into the picture archiving and communication system (PACS) to achieve full clinical value. Most commonly, a clinical user will depend on the patient to bring in a CD that contains imaging from another location. However, a number of issues can arise when using this type of solution. Firstly, a CD will not provide the clinical user with the full longitudinal record of the patient. Secondly, a CD often will not contain the report associated with the images. Finally, a CD is not seamless, due to the need to manually import the contents of the CD into the local PACS. In order to overcome these limitations, and provide clinical users with a greater benefit related to a patient's longitudinal DI history, the implementation of foreign exam management (FEM) at the local site level is required. This paper presents the experiences of FEM in practice. By leveraging industry standards and edge devices to support FEM, multiple sites with disparate PACS and radiology information system (RIS) vendors are able to seamlessly ingest foreign exams within their local PACS as if they are local exams.

Seamless presentation capture, indexing, and management

NASA Astrophysics Data System (ADS)

Hilbert, David M.; Cooper, Matthew; Denoue, Laurent; Adcock, John; Billsus, Daniel

2005-10-01

Technology abounds for capturing presentations. However, no simple solution exists that is completely automatic. ProjectorBox is a "zero user interaction" appliance that automatically captures, indexes, and manages presentation multimedia. It operates continuously to record the RGB information sent from presentation devices, such as a presenter's laptop, to display devices, such as a projector. It seamlessly captures high-resolution slide images, text and audio. It requires no operator, specialized software, or changes to current presentation practice. Automatic media analysis is used to detect presentation content and segment presentations. The analysis substantially enhances the web-based user interface for browsing, searching, and exporting captured presentations. ProjectorBox has been in use for over a year in our corporate conference room, and has been deployed in two universities. Our goal is to develop automatic capture services that address both corporate and educational needs.

Development of mass production type rigid polyurethane foam for LNG carrier using ozone depletion free blowing agent

NASA Astrophysics Data System (ADS)

Lee, Yeongbeom; Baek, Kye Hyun; Choe, Kunhyung; Han, Chonghun

2016-12-01

Nowadays the price of natural gas has become higher and the efficiency of propulsion system of liquefied natural gas (LNG) carriers has improved. Due to these trends, required boil-off rate (BOR) for LNG carrier has been lowered from 0.15%/day to 0.12%/day for conventional LNG carriers with sizes between 125,000 m3 and 170,000 m3. This requirement of BOR can be satisfied by using a rigid polyurethane foam (PUF) blown by 1,1-dichloro-1-fluoroethane (HCFC-141b) as an insulator. However, ozone depletion potential (ODP) of HCFC-141b requires alternative blowing agents with zero ODP such as hydroflurocarbons (HFCs) because of tougher environmental regulations. This paper introduces use of HFCs and additives to enhance properties of rigid PUFs under a mass production environment. Among the additives, perfluoroalkane (PFA) reduces thermal conductivity down to 12% and increases compressive strength up to 15% of a rigid PUF prepared in a laboratory scale. Based on this result, a mass production type rigid PUF is manufactured and is evaluated for BOR, mechanical strengths over operation temperature range, and thermal shock stability for LNG carriers. The BOR of the manufactured rigid PUF is below 0.12%/day, which satisfies the recent BOR specification for LNG carriers. The other required properties are also met the specifications for a conventional LNG carrier. Consequently, it is expected that the results in this paper will bring low BOR (<0.12%/day) LNG carries with rigid PUFs using ODP free blowing agents and contribute environmental protection through saving energy and preserving the ozone layer in the stratosphere.

Seamless Insert-Plasmid Assembly at High Efficiency and Low Cost

PubMed Central

Benoit, Roger M.; Ostermeier, Christian; Geiser, Martin; Li, Julia Su Zhou; Widmer, Hans; Auer, Manfred

2016-01-01

Seamless cloning methods, such as co-transformation cloning, sequence- and ligation-independent cloning (SLIC) or the Gibson assembly, are essential tools for the precise construction of plasmids. The efficiency of co-transformation cloning is however low and the Gibson assembly reagents are expensive. With the aim to improve the robustness of seamless cloning experiments while keeping costs low, we examined the importance of complementary single-stranded DNA ends for co-transformation cloning and the influence of single-stranded gaps in circular plasmids on SLIC cloning efficiency. Most importantly, our data show that single-stranded gaps in double-stranded plasmids, which occur in typical SLIC protocols, can drastically decrease the efficiency at which the DNA transforms competent E. coli bacteria. Accordingly, filling-in of single-stranded gaps using DNA polymerase resulted in increased transformation efficiency. Ligation of the remaining nicks did not lead to a further increase in transformation efficiency. These findings demonstrate that highly efficient insert-plasmid assembly can be achieved by using only T5 exonuclease and Phusion DNA polymerase, without Taq DNA ligase from the original Gibson protocol, which significantly reduces the cost of the reactions. We successfully used this modified Gibson assembly protocol with two short insert-plasmid overlap regions, each counting only 15 nucleotides. PMID:27073895

49 CFR 178.706 - Standards for rigid plastic IBCs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Standards for rigid plastic IBCs. 178.706 Section... Performance-Oriented Standards § 178.706 Standards for rigid plastic IBCs. (a) The provisions in this section apply to rigid plastic IBCs intended to contain solids or liquids. Rigid plastic IBC types are...

49 CFR 178.706 - Standards for rigid plastic IBCs.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Standards for rigid plastic IBCs. 178.706 Section... Performance-Oriented Standards § 178.706 Standards for rigid plastic IBCs. (a) The provisions in this section apply to rigid plastic IBCs intended to contain solids or liquids. Rigid plastic IBC types are...

49 CFR 178.706 - Standards for rigid plastic IBCs.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Standards for rigid plastic IBCs. 178.706 Section... Performance-Oriented Standards § 178.706 Standards for rigid plastic IBCs. (a) The provisions in this section apply to rigid plastic IBCs intended to contain solids or liquids. Rigid plastic IBC types are...

49 CFR 178.706 - Standards for rigid plastic IBCs.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Standards for rigid plastic IBCs. 178.706 Section... Performance-Oriented Standards § 178.706 Standards for rigid plastic IBCs. (a) The provisions in this section apply to rigid plastic IBCs intended to contain solids or liquids. Rigid plastic IBC types are...

Identifying Floppy and Rigid Regions in Proteins

NASA Astrophysics Data System (ADS)

Jacobs, D. J.; Thorpe, M. F.; Kuhn, L. A.

1998-03-01

In proteins it is possible to separate hard covalent forces involving bond lengths and bond angles from other weak forces. We model the microstructure of the protein as a generic bar-joint truss framework, where the hard covalent forces and strong hydrogen bonds are regarded as rigid bar constraints. We study the mechanical stability of proteins using FIRST (Floppy Inclusions and Rigid Substructure Topography) based on a recently developed combinatorial constraint counting algorithm (the 3D Pebble Game), which is a generalization of the 2D pebble game (D. J. Jacobs and M. F. Thorpe, ``Generic Rigidity: The Pebble Game'', Phys. Rev. Lett.) 75, 4051-4054 (1995) for the special class of bond-bending networks (D. J. Jacobs, "Generic Rigidity in Three Dimensional Bond-bending Networks", Preprint Aug (1997)). This approach is useful in identifying rigid motifs and flexible linkages in proteins, and thereby determines the essential degrees of freedom. We will show some preliminary results from the FIRST analysis on the myohemerythrin and lyozyme proteins.

21 CFR 876.5020 - External penile rigidity devices.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false External penile rigidity devices. 876.5020 Section 876.5020 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... maintain sufficient penile rigidity for sexual intercourse. External penile rigidity devices include vacuum...

21 CFR 876.5020 - External penile rigidity devices.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false External penile rigidity devices. 876.5020 Section 876.5020 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... maintain sufficient penile rigidity for sexual intercourse. External penile rigidity devices include vacuum...

21 CFR 876.5020 - External penile rigidity devices.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false External penile rigidity devices. 876.5020 Section 876.5020 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... maintain sufficient penile rigidity for sexual intercourse. External penile rigidity devices include vacuum...

21 CFR 876.5020 - External penile rigidity devices.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false External penile rigidity devices. 876.5020 Section 876.5020 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... maintain sufficient penile rigidity for sexual intercourse. External penile rigidity devices include vacuum...

21 CFR 876.5020 - External penile rigidity devices.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false External penile rigidity devices. 876.5020 Section 876.5020 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... maintain sufficient penile rigidity for sexual intercourse. External penile rigidity devices include vacuum...

Rigid-Rod Polyimides

NASA Technical Reports Server (NTRS)

Chuang, Kathy C.; Kinder, James D.; Hull, Diana L.; Youngs, Wiley J.

1996-01-01

Experimental polyimides relatively rigid synthesized in effort to exploit some of advantages of rodlike polymers, while alleviating disadvantages. Polymers used to make colorless fibers and transparent films for optical and electronic application.

21 CFR 882.1020 - Rigidity analyzer.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Rigidity analyzer. 882.1020 Section 882.1020 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Diagnostic Devices § 882.1020 Rigidity analyzer. (a...

21 CFR 882.1020 - Rigidity analyzer.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Rigidity analyzer. 882.1020 Section 882.1020 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES NEUROLOGICAL DEVICES Neurological Diagnostic Devices § 882.1020 Rigidity analyzer. (a...

Mental set and creative thought in social conflict: threat rigidity versus motivated focus.

PubMed

De Dreu, Carsten K W; Nijstad, Bernard A

2008-09-01

According to the traditional threat-rigidity reasoning, people in social conflict will be less flexible, less creative, more narrow-minded, and more rigid in their thinking when they adopt a conflict rather than a cooperation mental set. The authors propose and test an alternative, motivated focus account that better fits existing evidence. The authors report experimental results inconsistent with a threat-rigidity account, but supporting the idea that people focus their cognitive resources on conflict-related material more when in a conflict rather than a cooperation mental set: Disputants with a conflict (cooperation) set have broader (smaller) and more (less) inclusive cognitive categories when the domain of thought is (un)related to conflict (Experiment 1a-1b). Furthermore, they generate more, and more original competition tactics (Experiments 2-4), especially when they have low rather than high need for cognitive closure. Implications for conflict theory, for motivated information processing, and creativity research are discussed.

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

PubMed Central

Stephens, Andrew D.; Liu, Patrick Z.; Banigan, Edward J.; Almassalha, Luay M.; Backman, Vadim; Adam, Stephen A.; Goldman, Robert D.; Marko, John F.

2018-01-01

Nuclear shape and architecture influence gene localization, mechanotransduction, transcription, and cell function. Abnormal nuclear morphology and protrusions termed “blebs” are diagnostic markers for many human afflictions including heart disease, aging, progeria, and cancer. Nuclear blebs are associated with both lamin and chromatin alterations. A number of prior studies suggest that lamins dictate nuclear morphology, but the contributions of altered chromatin compaction remain unclear. We show that chromatin histone modification state dictates nuclear rigidity, and modulating it is sufficient to both induce and suppress nuclear blebs. Treatment of mammalian cells with histone deacetylase inhibitors to increase euchromatin or histone methyltransferase inhibitors to decrease heterochromatin results in a softer nucleus and nuclear blebbing, without perturbing lamins. Conversely, treatment with histone demethylase inhibitors increases heterochromatin and chromatin nuclear rigidity, which results in reduced nuclear blebbing in lamin B1 null nuclei. Notably, increased heterochromatin also rescues nuclear morphology in a model cell line for the accelerated aging disease Hutchinson–Gilford progeria syndrome caused by mutant lamin A, as well as cells from patients with the disease. Thus, chromatin histone modification state is a major determinant of nuclear blebbing and morphology via its contribution to nuclear rigidity. PMID:29142071

Rigidity and retention of root canal posts.

PubMed

Purton, D G; Chandler, N P; Love, R M

1998-03-28

To test the rigidity and the retention into roots of parallel root canal posts, one a spiral vented titanium post and the other a spiral serrated, hollow, stainless steel post. A serrated, stainless steel post was used as the control. A three-point bending test was used to test rigidity. To test retention, ten posts of each type were cemented into the roots of extracted teeth with a resin cement and the tensile loads required to remove them were compared using Student's t and Mann-Whitney U tests. The serrated stainless steel posts were significantly more rigid than either of the other types. The titanium posts and the stainless steel hollow posts were not significantly different in rigidity. The serrated, stainless steel posts were significantly better retained than either of the other types. The titanium posts showed greater retention than the hollow posts. Within the limits of the study the stainless steel, serrated posts were superior to the two newer types in terms of rigidity and retention into roots.

Multiscale multiphysics and multidomain models—Flexibility and rigidity

PubMed Central

Xia, Kelin; Opron, Kristopher; Wei, Guo-Wei

2013-01-01

The emerging complexity of large macromolecules has led to challenges in their full scale theoretical description and computer simulation. Multiscale multiphysics and multidomain models have been introduced to reduce the number of degrees of freedom while maintaining modeling accuracy and achieving computational efficiency. A total energy functional is constructed to put energies for polar and nonpolar solvation, chemical potential, fluid flow, molecular mechanics, and elastic dynamics on an equal footing. The variational principle is utilized to derive coupled governing equations for the above mentioned multiphysical descriptions. Among these governing equations is the Poisson-Boltzmann equation which describes continuum electrostatics with atomic charges. The present work introduces the theory of continuum elasticity with atomic rigidity (CEWAR). The essence of CEWAR is to formulate the shear modulus as a continuous function of atomic rigidity. As a result, the dynamics complexity of a macromolecular system is separated from its static complexity so that the more time-consuming dynamics is handled with continuum elasticity theory, while the less time-consuming static analysis is pursued with atomic approaches. We propose a simple method, flexibility-rigidity index (FRI), to analyze macromolecular flexibility and rigidity in atomic detail. The construction of FRI relies on the fundamental assumption that protein functions, such as flexibility, rigidity, and energy, are entirely determined by the structure of the protein and its environment, although the structure is in turn determined by all the interactions. As such, the FRI measures the topological connectivity of protein atoms or residues and characterizes the geometric compactness of the protein structure. As a consequence, the FRI does not resort to the interaction Hamiltonian and bypasses matrix diagonalization, which underpins most other flexibility analysis methods. FRI's computational complexity is of

75 FR 33330 - Seamless Refined Copper Pipe and Tube From China and Mexico

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

..., threaded), coating (e.g., plastic, paint), insulation, attachments (e.g., plain, capped, plugged, with... seamless refined copper tubes (with or without fittings or insulation) suitable for connecting an outdoor air conditioner or heat pump to an indoor evaporator unit. The phrase ``all sets of covered products...

21 CFR 874.4680 - Bronchoscope (flexible or rigid) and accessories.

Code of Federal Regulations, 2011 CFR

2011-04-01

... such as stainless steel or flexible plastic. This generic type of device includes the rigid ventilating... foreign body claw, bronchoscope tubing, flexible biopsy forceps, rigid biopsy curette, flexible biopsy brush, rigid biopsy forceps, flexible biopsy curette, and rigid bronchoscope aspirating tube, but...

Advanced Rigid Ablative TPS

NASA Technical Reports Server (NTRS)

Gasch, Matthew J.

2011-01-01

NASA Exploration Systems Mission Directorate s (ESMD) Entry, Descent, and Landing (EDL) Technology Development Project (TDP) and the NASA Aeronautics Research Mission Directorate s (ARMD) Hypersonics Project are developing new advanced rigid ablators in an effort to substantially increase reliability, decrease mass, and reduce life cycle cost of rigid aeroshell-based entry systems for multiple missions. Advanced Rigid Ablators combine ablation resistant top layers capable of high heat flux entry and enable high-speed EDL with insulating mass-efficient bottom that, insulate the structure and lower the areal weight. These materials may benefit Commercial Orbital Transportation Services (COTS) vendors and may potentially enable new NASA missions for higher velocity returns (e.g. asteroid, Mars). The materials have been thermally tested to 400-450 W/sq cm at the Laser Hardened Materials Evaluation Lab (LHMEL), Hypersonics Materials Evaluation Test System (HyMETS) and in arcjet facilities. Tested materials exhibit much lower backface temperatures and reduced recession over the baseline materials (PICA). Although the EDL project is ending in FY11, NASA in-house development of advanced ablators will continue with a focus on varying resin systems and fiber/resin interactions.

Perceptual, Cognitive, and Personality Rigidity in Parkinson’s Disease

PubMed Central

Díaz-Santos, Mirella; Cao, Bo; Yazdanbakhsh, Arash; Norton, Daniel J.; Neargarder, Sandy; Cronin-Golomb, Alice

2015-01-01

Parkinson’s disease (PD) is associated with motor and non-motor rigidity symptoms (e.g., cognitive and personality). The question is raised as to whether rigidity in PD also extends to perception, and if so, whether perceptual, cognitive, and personality rigidities are correlated. Bistable stimuli were presented to 28 non-demented individuals with PD and 26 normal control adults (NC). Necker cube perception and binocular rivalry were examined during passive viewing, and the Necker cube was additionally used for two volitional-control conditions: Hold one percept in front, and Switch between the two percepts. Relative to passive viewing, PD were significantly less able than NC to reduce dominance durations in the Switch condition, indicating perceptual rigidity. Tests of cognitive flexibility and a personality questionnaire were administered to explore the association with perceptual rigidity. Cognitive flexibility was not correlated with perceptual rigidity for either group. Personality (novelty seeking) correlated with dominance durations on Necker passive viewing for PD but not NC. The results indicate the presence in mild-moderate PD of perceptual rigidity and suggest shared neural substrates with novelty seeking, but functional divergence from those supporting cognitive flexibility. The possibility is raised that perceptual rigidity may be a harbinger of cognitive inflexibility later in the disease course. PMID:25640973

The Rigid Orthogonal Procrustes Rotation Problem

ERIC Educational Resources Information Center

ten Berge, Jos M. F.

2006-01-01

The problem of rotating a matrix orthogonally to a best least squares fit with another matrix of the same order has a closed-form solution based on a singular value decomposition. The optimal rotation matrix is not necessarily rigid, but may also involve a reflection. In some applications, only rigid rotations are permitted. Gower (1976) has…

Seamless Learning in the Mobile Age: A Theoretical and Methodological Discussion on Using Cooperative Inquiry to Study Digital Kids On-the-Move

ERIC Educational Resources Information Center

Toh, Yancy; So, Hyo-Jeong; Seow, Peter; Chen, Wenli; Looi, Chee-Kit

2013-01-01

This paper shares the theoretical and methodological frameworks that are deployed in a 3-year study to examine how Singapore primary school students leverage on mobile technology for seamless learning. This notion of seamless learning refers to the integrated and synergistic effects of learning in both formal and informal settings, which is…

Rigid shells enhance survival of gekkotan eggs.

PubMed

Andrews, Robin M

2015-11-01

The majority of lizards and snakes produce permeable parchment-shelled eggs that require high moisture conditions for successful embryonic development. One clade of gekkotan lizards is an exception; females produce relatively impermeable rigid-shelled eggs that normally incubate successfully under low moisture conditions. I tested the hypothesis that the rigid-shell increases egg survival during incubation, but only under low moisture conditions. To test this hypothesis, I incubated rigid-shelled eggs of Chondrodactylus turneri under low and under high moisture conditions. Eggs were incubated with parchment-shelled eggs of Eublepharis macularius to insure that incubation conditions were suitable for parchment-shelled eggs. Chondrodactylus turneri eggs had very high survival (>90%) when they were incubated under low moisture conditions. In contrast, eggs incubated under high moisture conditions had low survival overall, and lower survival than those of the parchment-shelled eggs of E. macularius. Mortality of C. turneri and E. macularius eggs incubated under high moisture conditions was the result of fungal infection, a common source of egg mortality for squamates under laboratory and field conditions. These observations document high survival of rigid-shelled eggs under low moisture conditions because eggs escape from fungal infection. Highly mineralized rigid shells also make egg survival independent of moisture availability and may also provide protection from small invertebrates in nature. Enhanced egg survival could thus compensate for the low reproductive output of gekkotans that produce rigid-shelled eggs. © 2015 Wiley Periodicals, Inc.

Rigid Polyurethane Foam (RPF) Technology for Countermine (SEA) Program - Phase 1

DTIC Science & Technology

1997-01-01

Form ApprovedOMB No. 0704-0188 Public reporting burden for the collection of information is estimated to average 1 hour...05 MAY 1997 2. REPORT TYPE 3. DATES COVERED 00-00-1997 to 00-00-1997 4. TITLE AND SUBTITLE Rigid Polyurethane Foam (RPF) Technology for...unclassified b. ABSTRACT unclassified c. THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18

Fiberglass-Reinforced Rigid Polyurethane Expedient Pavement Subject to Simulated F-4 Aircraft Traffic.

DTIC Science & Technology

1980-05-01

34 4,. * ., Table B-I. CPR-739 Rigid Polyurethane Foam Component Characteristics [ Cream Time, 120 sec; Rise Time, 13 sec; Cure Time, 24 hr at 750F...INC. E Colic Soil Tech Dept. Pennsauken. NJ SANDIA LABORATORIES Library Div., Livermore CA SCHUPACK ASSOC SO. NORWALK. CT (SCHUPACK) SHELL OIL CO

A Field Study of a Video Supported Seamless-Learning-Setting with Elementary Learners

ERIC Educational Resources Information Center

Fößl, Thomas; Ebner, Martin; Schön, Sandra; Holzinger, Andreas

2016-01-01

Seamless Learning shall initiate human learning processes that exceeds lesson and classroom limits. At the same time this approach fosters a self-regulated learning, by means of inspirational, open education settings. Advanced learning materials are easily accessible via mobile digital devices connected to the Internet. In this study it was…

A Seamless Ubiquitous Telehealthcare Tunnel

PubMed Central

Cheng, Po-Hsun; Lin, Bor-Shing; Yu, Chu; Hu, Shun-Hsiang; Chen, Sao-Jie

2013-01-01

Mobile handheld devices are rapidly using to implement healthcare services around the World. Fundamentally, these services utilize telemedicine technologies. A disconnection of a mobile telemedicine system usually results in an interruption, which is embarrassing, and reconnection is necessary during the communication session. In this study, the Stream Control Transmission Protocol (SCTP) is adopted to build a stable session tunnel to guarantee seamless switching among heterogeneous wireless communication standards, such as Wi-Fi and 3G. This arrangement means that the telemedicine devices will not be limited by a fixed wireless connection and can switch to a better wireless channel if necessary. The tunnel can transmit plain text, binary data, and video streams. According to the evaluation of the proposed software-based SCTP-Tunnel middleware shown, the performance is lower than anticipated and is slightly slower than a fixed connection. However, the transmission throughput is still acceptable for healthcare professionals in a healthcare enterprise or home care site. It is necessary to build more heterogeneous wireless protocols into the proposed tunnel-switching scheme to support all possible communication protocols. In addition, SCTP is another good choice for promoting communication in telemedicine and healthcare fields. PMID:23917812

Rigidity controllable polishing tool based on magnetorheological effect

NASA Astrophysics Data System (ADS)

Wang, Jia; Wan, Yongjian; Shi, Chunyan

2012-10-01

A stable and predictable material removal function (MRF) plays a crucial role in computer controlled optical surfacing (CCOS). For physical contact polishing case, the stability of MRF depends on intimate contact between polishing interface and workpiece. Rigid laps maintain this function in polishing spherical surfaces, whose curvature has no variation with the position on the surface. Such rigid laps provide smoothing effect for mid-spatial frequency errors, but can't be used in aspherical surfaces for they will destroy the surface figure. Flexible tools such as magnetorheological fluid or air bonnet conform to the surface [1]. They lack rigidity and provide little natural smoothing effect. We present a rigidity controllable polishing tool that uses a kind of magnetorheological elastomers (MRE) medium [2]. It provides the ability of both conforming to the aspheric surface and maintaining natural smoothing effect. What's more, its rigidity can be controlled by the magnetic field. This paper will present the design, analysis, and stiffness variation mechanism model of such polishing tool [3].

21 CFR 874.4680 - Bronchoscope (flexible or rigid) and accessories.

Code of Federal Regulations, 2013 CFR

2013-04-01

... foreign body claw, bronchoscope tubing, flexible biopsy forceps, rigid biopsy curette, flexible biopsy brush, rigid biopsy forceps, flexible biopsy curette, and rigid bronchoscope aspirating tube, but...

21 CFR 874.4680 - Bronchoscope (flexible or rigid) and accessories.

Code of Federal Regulations, 2012 CFR

2012-04-01

... foreign body claw, bronchoscope tubing, flexible biopsy forceps, rigid biopsy curette, flexible biopsy brush, rigid biopsy forceps, flexible biopsy curette, and rigid bronchoscope aspirating tube, but...

21 CFR 874.4680 - Bronchoscope (flexible or rigid) and accessories.

Code of Federal Regulations, 2014 CFR

2014-04-01

... foreign body claw, bronchoscope tubing, flexible biopsy forceps, rigid biopsy curette, flexible biopsy brush, rigid biopsy forceps, flexible biopsy curette, and rigid bronchoscope aspirating tube, but...

Thermostability in rubredoxin and its relationship to mechanical rigidity

NASA Astrophysics Data System (ADS)

Rader, A. J.

2010-03-01

The source of increased stability in proteins from organisms that thrive in extreme thermal environments is not well understood. Previous experimental and theoretical studies have suggested many different features possibly responsible for such thermostability. Many of these thermostabilizing mechanisms can be accounted for in terms of structural rigidity. Thus a plausible hypothesis accounting for this remarkable stability in thermophilic enzymes states that these enzymes have enhanced conformational rigidity at temperatures below their native, functioning temperature. Experimental evidence exists to both support and contradict this supposition. We computationally investigate the relationship between thermostability and rigidity using rubredoxin as a case study. The mechanical rigidity is calculated using atomic models of homologous rubredoxin structures from the hyperthermophile Pyrococcus furiosus and mesophile Clostridium pasteurianum using the FIRST software. A global increase in structural rigidity (equivalently a decrease in flexibility) corresponds to an increase in thermostability. Locally, rigidity differences (between mesophilic and thermophilic structures) agree with differences in protection factors.

Minimal energy configurations of gravitationally interacting rigid bodies

NASA Astrophysics Data System (ADS)

Moeckel, Richard

2017-05-01

Consider a collection of n rigid, massive bodies interacting according to their mutual gravitational attraction. A relative equilibrium motion is one where the entire configuration rotates rigidly and uniformly about a fixed axis in R^3. Such a motion is possible only for special positions and orientations of the bodies. A minimal energy motion is one which has the minimum possible energy in its fixed angular momentum level. While every minimal energy motion is a relative equilibrium motion, the main result here is that a relative equilibrium motion of n≥3 disjoint rigid bodies is never an energy minimizer. This generalizes a known result about point masses to the case of rigid bodies.

49 CFR 587.18 - Dimensions of fixed rigid barrier.

Code of Federal Regulations, 2010 CFR

2010-10-01

... TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) DEFORMABLE BARRIERS Offset Deformable Barrier § 587.18 Dimensions of fixed rigid barrier. (a) The fixed rigid barrier has a mass of not... 49 Transportation 7 2010-10-01 2010-10-01 false Dimensions of fixed rigid barrier. 587.18 Section...

49 CFR 587.18 - Dimensions of fixed rigid barrier.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 7 2011-10-01 2011-10-01 false Dimensions of fixed rigid barrier. 587.18 Section 587.18 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY... Deformable Barrier § 587.18 Dimensions of fixed rigid barrier. (a) The fixed rigid barrier has a mass of not...

49 CFR 587.18 - Dimensions of fixed rigid barrier.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 7 2012-10-01 2012-10-01 false Dimensions of fixed rigid barrier. 587.18 Section 587.18 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY... Deformable Barrier § 587.18 Dimensions of fixed rigid barrier. (a) The fixed rigid barrier has a mass of not...

49 CFR 587.18 - Dimensions of fixed rigid barrier.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 7 2014-10-01 2014-10-01 false Dimensions of fixed rigid barrier. 587.18 Section 587.18 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY... Deformable Barrier § 587.18 Dimensions of fixed rigid barrier. (a) The fixed rigid barrier has a mass of not...

49 CFR 587.18 - Dimensions of fixed rigid barrier.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 7 2013-10-01 2013-10-01 false Dimensions of fixed rigid barrier. 587.18 Section 587.18 Transportation Other Regulations Relating to Transportation (Continued) NATIONAL HIGHWAY... Deformable Barrier § 587.18 Dimensions of fixed rigid barrier. (a) The fixed rigid barrier has a mass of not...

Roof-crush strength improvement using rigid polyurethane foam

NASA Astrophysics Data System (ADS)

Lilley, K.; Mani, A.

1998-08-01

Recent bending tests show the effectiveness of rigid, polyurethane foam in improving the strength of automotive body structures. By using foam, it is possible to reduce pillar sections, and to reduce thicknesses or eliminate reinforcements inside the pillars, and thereby offset the mass increase due to the foam filling. Further tests showed that utilizing the foam filling in a B-pillar to reduce section size can save ~20 mm that could be utilized to add energy absorbing structures in order to meet the new interior head impact requirements specified by the federal motor vehicle safety standards (FMVSS) 201 Head Impact Protection upgrade.

Towards Seamless Validation of Land Cover Data

NASA Astrophysics Data System (ADS)

Chuprikova, Ekaterina; Liebel, Lukas; Meng, Liqiu

2018-05-01

This article demonstrates the ability of the Bayesian Network analysis for the recognition of uncertainty patterns associated with the fusion of various land cover data sets including GlobeLand30, CORINE (CLC2006, Germany) and land cover data derived from Volunteered Geographic Information (VGI) such as Open Street Map (OSM). The results of recognition are expressed as probability and uncertainty maps which can be regarded as a by-product of the GlobeLand30 data. The uncertainty information may guide the quality improvement of GlobeLand30 by involving the ground truth data, information with superior quality, the know-how of experts and the crowd intelligence. Such an endeavor aims to pave a way towards a seamless validation of global land cover data on the one hand and a targeted knowledge discovery in areas with higher uncertainty values on the other hand.

21 CFR 886.5916 - Rigid gas permeable contact lens.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Rigid gas permeable contact lens. 886.5916 Section... (CONTINUED) MEDICAL DEVICES OPHTHALMIC DEVICES Therapeutic Devices § 886.5916 Rigid gas permeable contact lens. (a) Identification. A rigid gas permeable contact lens is a device intended to be worn directly...

21 CFR 886.5916 - Rigid gas permeable contact lens.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Rigid gas permeable contact lens. 886.5916 Section... (CONTINUED) MEDICAL DEVICES OPHTHALMIC DEVICES Therapeutic Devices § 886.5916 Rigid gas permeable contact lens. (a) Identification. A rigid gas permeable contact lens is a device intended to be worn directly...

Mesh Nanoelectronics: Seamless Integration of Electronics with Tissues.

PubMed

Dai, Xiaochuan; Hong, Guosong; Gao, Teng; Lieber, Charles M

2018-02-20

Nanobioelectronics represents a rapidly developing field with broad-ranging opportunities in fundamental biological sciences, biotechnology, and medicine. Despite this potential, seamless integration of electronics has been difficult due to fundamental mismatches, including size and mechanical properties, between the elements of the electronic and living biological systems. In this Account, we discuss the concept, development, key demonstrations, and future opportunities of mesh nanoelectronics as a general paradigm for seamless integration of electronics within synthetic tissues and live animals. We first describe the design and realization of hybrid synthetic tissues that are innervated in three dimensions (3D) with mesh nanoelectronics where the mesh serves as both as a tissue scaffold and as a platform of addressable electronic devices for monitoring and manipulating tissue behavior. Specific examples of tissue/nanoelectronic mesh hybrids highlighted include 3D neural tissue, cardiac patches, and vascular constructs, where the nanoelectronic devices have been used to carry out real-time 3D recording of electrophysiological and chemical signals in the tissues. This novel platform was also exploited for time-dependent 3D spatiotemporal mapping of cardiac tissue action potentials during cell culture and tissue maturation as well as in response to injection of pharmacological agents. The extension to simultaneous real-time monitoring and active control of tissue behavior is further discussed for multifunctional mesh nanoelectronics incorporating both recording and stimulation devices, providing the unique capability of bidirectional interfaces to cardiac tissue. In the case of live animals, new challenges must be addressed, including minimally invasive implantation, absence of deleterious chronic tissue response, and long-term capability for monitoring and modulating tissue activity. We discuss each of these topics in the context of implantation of mesh

49 CFR 178.36 - Specification 3A and 3AX seamless steel cylinders.

Code of Federal Regulations, 2011 CFR

2011-10-01

... conform to the following: (1) A DOT-3A cylinder is a seamless steel cylinder with a water capacity... steel cylinder with a water capacity not less than 1,000 pounds and a service pressure of at least 500... per unit of length of the straight cylindrical portion filled with water and compressed to the...

49 CFR 178.36 - Specification 3A and 3AX seamless steel cylinders.

Code of Federal Regulations, 2010 CFR

2010-10-01

... conform to the following: (1) A DOT-3A cylinder is a seamless steel cylinder with a water capacity... steel cylinder with a water capacity not less than 1,000 pounds and a service pressure of at least 500... per unit of length of the straight cylindrical portion filled with water and compressed to the...

Seamless Assessment in Science: A Guide for Elementary & Middle School. Grades: K - 8

ERIC Educational Resources Information Center

National Science Teachers Association (NJ3), 2006

2006-01-01

When a classroom is opened to inquiry-based learning, teachers can no longer rely solely on traditional end-of-unit tests. "Seamless Assessment" is a one-stop guide to strategies that mirror the investigatory spirit. Working with the popular 5E model as an instructional framework, the authors have designed methods for embedding formative and…

Fracture mechanics data for 2024-T861 and 2124-T851 aluminum

NASA Technical Reports Server (NTRS)

Pionke, L. J.; Linback, R. K.

1974-01-01

The fracture toughness and fatigue flaw growth characteristics of 2024-T861 and 2124-T851 aluminum were evaluated under plane stress conditions. Center cracked tension specimens were employed to evaluate these properties under a number of different test conditions which included variations in specimen thickness, specimen orientation, test environment, and initial flaw size. The effect of buckling was also investigated for all tests of thin gage specimens, and the effect of frequency and stress ratio was evaluated for the cyclic tests. Fracture toughness test results were analyzed and presented in terms of fracture resistance curves; fatigue flaw growth data was analyzed using empirical rate models. The results of the study indicate that both fracture toughness and resistance to fatigue crack growth improve with increasing temperature and decreasing thickness. The presence of buckling during testing of thin gage panels was found to degrade the resistance to fatigue flaw growth only at elevated temperatures.

21 CFR 876.3630 - Penile rigidity implant.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Penile rigidity implant. 876.3630 Section 876.3630 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES GASTROENTEROLOGY-UROLOGY DEVICES Prosthetic Devices § 876.3630 Penile rigidity implant. (a...

Seamless interworking architecture for WBAN in heterogeneous wireless networks with QoS guarantees.

PubMed

Khan, Pervez; Ullah, Niamat; Ullah, Sana; Kwak, Kyung Sup

2011-10-01

The IEEE 802.15.6 standard is a communication standard optimized for low-power and short-range in-body/on-body nodes to serve a variety of medical, consumer electronics and entertainment applications. Providing high mobility with guaranteed Quality of Service (QoS) to a WBAN user in heterogeneous wireless networks is a challenging task. A WBAN uses a Personal Digital Assistant (PDA) to gather data from body sensors and forwards it to a remote server through wide range wireless networks. In this paper, we present a coexistence study of WBAN with Wireless Local Area Networks (WLAN) and Wireless Wide Area Networks (WWANs). The main issue is interworking of WBAN in heterogenous wireless networks including seamless handover, QoS, emergency services, cooperation and security. We propose a Seamless Interworking Architecture (SIA) for WBAN in heterogenous wireless networks based on a cost function. The cost function is based on power consumption and data throughput costs. Our simulation results show that the proposed scheme outperforms typical approaches in terms of throughput, delay and packet loss rate.

A new optimal seam method for seamless image stitching

NASA Astrophysics Data System (ADS)

Xue, Jiale; Chen, Shengyong; Cheng, Xu; Han, Ying; Zhao, Meng

2017-07-01

A novel optimal seam method which aims to stitch those images with overlapping area more seamlessly has been propos ed. Considering the traditional gradient domain optimal seam method and fusion algorithm result in bad color difference measurement and taking a long time respectively, the input images would be converted to HSV space and a new energy function is designed to seek optimal stitching path. To smooth the optimal stitching path, a simplified pixel correction and weighted average method are utilized individually. The proposed methods exhibit performance in eliminating the stitching seam compared with the traditional gradient optimal seam and high efficiency with multi-band blending algorithm.

Reversible Rigidity Control Using Low Melting Temperature Alloys

NASA Astrophysics Data System (ADS)

Shan, Wanliang; Lu, Tong; Majidi, Carmel

2013-03-01

Inspired by nature, materials able to achieve rapid rigidity changes have important applications for human body protection in military and many other areas. This talk presents the fabrication and design of soft-matter technologies that exhibit rapid reversible rigidity control. Fabricated with a masked deposition technique, the soft-matter composite contains liquid-phase and phase-changing metal alloys embedded in a soft and highly stretchable elastomer. The composite material can reversibly change its rigidity by three orders of magnitude and sustain large deformation.

Rigid fixation of facial fractures in children.

PubMed

Koltai, P J; Rabkin, D; Hoehn, J

1995-01-01

This article presents a retrospective analysis of a selective use of rigid fixation among 62 children with facial fractures, treated at a Level I trauma center over a 5-year period (1986-1991). There were 21 mandible fractures, 11 orbital fractures, 11 zygomaticomalar complex fractures, 7 nasal fractures, 5 maxillary fractures, 3 pan-facial fractures, 2 nasal-orbital-ethmoidal complex fractures, and 2 frontal sinus fractures. Only 18 children had rigid fixation of their injuries. Complications of Le Fort upper facial fractures repaired with rigid fixation involved perioperative sinusitis; one case required oral antibiotics, the other ethmoidectomy and maxillary antrostomy. One child with a Le Fort fracture had delayed exposure of a zygomaticomalar buttress plate, which required surgical removal. Permanent enophthalmos occurred in two children with Le Fort fractures. The authors conclude that traditional conservative management is appropriate in most cases. However, in children aged 13 and older with mandible fractures and children with complex mid- and upper facial fractures, a judicious use of rigid fixation has advantages over the traditional techniques.

Endoscope shaft-rigidity control mechanism: "FORGUIDE".

PubMed

Loeve, Arjo J; Plettenburg, Dick H; Breedveld, Paul; Dankelman, Jenny

2012-02-01

Recent developments in flexible endoscopy and other fields of medical technology have raised the need for compact slender shafts that can be made rigid and compliant at will. A novel compact mechanism, named FORGUIDE, with this functionality was developed. The FORGUIDE shaft rigidifies due to friction between a ring of cables situated between a spring and an inflated tube. A mathematical model for the FORGUIDE mechanism working principle was made and used to obtain understanding of this mechanism, predict the maximum rigidity of a FORGUIDE shaft design, and tune its design variables. The mathematical model gave suggestions for significant performance improvement by fine-tuning the design. A prototype FORGUIDE shaft was built and put to a series of bench tests. These tests showed that the FORGUIDE mechanism provides a reliable and simple way to control the rigidity of a flexible shaft. © 2011 IEEE

Soft-matter composites with electrically tunable elastic rigidity

NASA Astrophysics Data System (ADS)

Shan, Wanliang; Lu, Tong; Majidi, Carmel

2013-08-01

We use a phase-changing metal alloy to reversibly tune the elastic rigidity of an elastomer composite. The elastomer is embedded with a sheet of low-melting-point Field’s metal and an electric Joule heater composed of a serpentine channel of liquid-phase gallium-indium-tin (Galinstan®) alloy. At room temperature, the embedded Field’s metal is solid and the composite remains elastically rigid. Joule heating causes the Field’s metal to melt and allows the surrounding elastomer to freely stretch and bend. Using a tensile testing machine, we measure that the effective elastic modulus of the composite reversibly changes by four orders of magnitude when powered on and off. This dramatic change in rigidity is accurately predicted with a model for an elastic composite. Reversible rigidity control is also accomplished by replacing the Field’s metal with shape memory polymer. In addition to demonstrating electrically tunable rigidity with an elastomer, we also introduce a new technique to rapidly produce soft-matter electronics and multifunctional materials in several minutes with laser-patterned adhesive film and masked deposition of liquid-phase metal alloy.

Analysis and optimization of the active rigidity joint

NASA Astrophysics Data System (ADS)

Manzo, Justin; Garcia, Ephrahim

2009-12-01

The active rigidity joint is a composite mechanism using shape memory alloy and shape memory polymer to create a passively rigid joint with thermally activated deflection. A new model for the active rigidity joint relaxes constraints of earlier methods and allows for more accurate deflection predictions compared to finite element results. Using an iterative process to determine the strain distribution and deflection, the method demonstrates accurate results for both surface bonded and embedded actuators with and without external loading. Deflection capabilities are explored through simulated annealing heuristic optimization using a variety of cost functions to explore actuator performance. A family of responses presents actuator characteristics in terms of load bearing and deflection capabilities given material and thermal constraints. Optimization greatly expands the available workspace of the active rigidity joint from the initial configuration, demonstrating specific work capabilities comparable to those of muscle tissue.

Contribution of Jules Froment to the study of parkinsonian rigidity.

PubMed

Broussolle, Emmanuel; Krack, Paul; Thobois, Stéphane; Xie-Brustolin, Jing; Pollak, Pierre; Goetz, Christopher G

2007-05-15

Rigidity is commonly defined as a resistance to passive movement. In Parkinson's disease (PD), two types of rigidity are classically recognized which may coexist, "leadpipe " and "cogwheel". Charcot was the first to investigate parkinsonian rigidity during the second half of the nineteenth century, whereas Negro and Moyer described cogwheel rigidity at the beginning of the twentieth century. Jules Froment, a French neurologist from Lyon, contributed to the study of parkinsonian rigidity during the 1920s. He investigated rigidity of the wrist at rest in a sitting position as well as in stable and unstable standing postures, both clinically and with physiological recordings using a myograph. With Gardère, Froment described enhanced resistance to passive movements of a limb about a joint that can be detected specifically when there is a voluntary action of another contralateral body part. This has been designated in the literature as the "Froment's maneuver " and the activation or facilitation test. In addition, Froment showed that parkinsonian rigidity diminishes, vanishes, or enhances depending on the static posture of the body. He proposed that in PD "maintenance stabilization " of the body is impaired and that "reactive stabilization " becomes the operative mode of muscular tone control. He considered "rigidification " as compensatory against the forces of gravity. Froment also demonstrated that parkinsonian rigidity increases during the Romberg test, gaze deviation, and oriented attention. In their number, breadth, and originality, Froment's contributions to the study of parkinsonian rigidity remain currently relevant to clinical and neurophysiological issues of PD. (c) 2007 Movement Disorder Society.

Roto-orbital dynamics of a triaxial rigid body around a sphere. Relative equilibria and stability

NASA Astrophysics Data System (ADS)

Crespo, F.; Ferrer, S.

2018-06-01

We study the roto-orbital motion of a triaxial rigid body around a sphere, which is assumed to be much more massive than the triaxial body. The associated dynamics of this system, which consists of a normalized Hamiltonian with respect to the fast angles (partial averaging), is investigated making use of variables referred to the total angular momentum. The first order approximation of this model is integrable. We carry out the analysis of the relative equilibria, which hinges principally in the dihedral angle between the orbital and rotational planes and the ratio among the moments of inertia ρ = (B - A) / (2 C - B - A) . In particular, the dynamics of the body frame, though formally given by the classical Euler equations, experiences changes of stability in the principal directions related to the roto-orbital coupling. When ρ = 1 / 3 , we find a family of relative equilibria connected to the unstable equilibria of the free rigid body.

Non-rigid image registration using a statistical spline deformation model.

PubMed

Loeckx, Dirk; Maes, Frederik; Vandermeulen, Dirk; Suetens, Paul

2003-07-01

We propose a statistical spline deformation model (SSDM) as a method to solve non-rigid image registration. Within this model, the deformation is expressed using a statistically trained B-spline deformation mesh. The model is trained by principal component analysis of a training set. This approach allows to reduce the number of degrees of freedom needed for non-rigid registration by only retaining the most significant modes of variation observed in the training set. User-defined transformation components, like affine modes, are merged with the principal components into a unified framework. Optimization proceeds along the transformation components rather then along the individual spline coefficients. The concept of SSDM's is applied to the temporal registration of thorax CR-images using pattern intensity as the registration measure. Our results show that, using 30 training pairs, a reduction of 33% is possible in the number of degrees of freedom without deterioration of the result. The same accuracy as without SSDM's is still achieved after a reduction up to 66% of the degrees of freedom.

Sensing of substratum rigidity and directional migration by fast-crawling cells

NASA Astrophysics Data System (ADS)

Okimura, Chika; Sakumura, Yuichi; Shimabukuro, Katsuya; Iwadate, Yoshiaki

2018-05-01

Living cells sense the mechanical properties of their surrounding environment and respond accordingly. Crawling cells detect the rigidity of their substratum and migrate in certain directions. They can be classified into two categories: slow-moving and fast-moving cell types. Slow-moving cell types, such as fibroblasts, smooth muscle cells, mesenchymal stem cells, etc., move toward rigid areas on the substratum in response to a rigidity gradient. However, there is not much information on rigidity sensing in fast-moving cell types whose size is ˜10 μ m and migration velocity is ˜10 μ m /min . In this study, we used both isotropic substrata with different rigidities and an anisotropic substratum that is rigid on the x axis but soft on the y axis to demonstrate rigidity sensing by fast-moving Dictyostelium cells and neutrophil-like differentiated HL-60 cells. Dictyostelium cells exerted larger traction forces on a more rigid isotropic substratum. Dictyostelium cells and HL-60 cells migrated in the "soft" direction on the anisotropic substratum, although myosin II-null Dictyostelium cells migrated in random directions, indicating that rigidity sensing of fast-moving cell types differs from that of slow types and is induced by a myosin II-related process.

Sensing of substratum rigidity and directional migration by fast-crawling cells.

PubMed

Okimura, Chika; Sakumura, Yuichi; Shimabukuro, Katsuya; Iwadate, Yoshiaki

2018-05-01

Living cells sense the mechanical properties of their surrounding environment and respond accordingly. Crawling cells detect the rigidity of their substratum and migrate in certain directions. They can be classified into two categories: slow-moving and fast-moving cell types. Slow-moving cell types, such as fibroblasts, smooth muscle cells, mesenchymal stem cells, etc., move toward rigid areas on the substratum in response to a rigidity gradient. However, there is not much information on rigidity sensing in fast-moving cell types whose size is ∼10 μm and migration velocity is ∼10 μm/min. In this study, we used both isotropic substrata with different rigidities and an anisotropic substratum that is rigid on the x axis but soft on the y axis to demonstrate rigidity sensing by fast-moving Dictyostelium cells and neutrophil-like differentiated HL-60 cells. Dictyostelium cells exerted larger traction forces on a more rigid isotropic substratum. Dictyostelium cells and HL-60 cells migrated in the "soft" direction on the anisotropic substratum, although myosin II-null Dictyostelium cells migrated in random directions, indicating that rigidity sensing of fast-moving cell types differs from that of slow types and is induced by a myosin II-related process.

Balancing of Rigid and Flexible Rotors

DTIC Science & Technology

1986-01-01

and Vibration Information Center at NRL and Dr. J. Gordan Showalter, the acting director for their supportive recognition of the importance of this...RIGID AND FLEXIBLE ROTORS Comparizon of Exact-Poriqt.SpWed and Least-Squareq Influence Coefficient ýIalncin8 The least-squares procedure differs from the...that the critical speeds are still to be iI2 486 BALANCING OF RIGID AND FLEXIBLE ROTORS 101 too .10 l0-* -Stat~llon- STATION 2 0 2000 0000 600 logo

Cross-continuum Care Continuity: Achieving Seamless Care and Managing Comorbidities.

PubMed

Boston-Fleischhauer, Carol; Rose, Robert; Hartwig, Laurie

As healthcare systems continue to design care models responsive to payment changes and the assumption of clinical and financial risk, the need exists for a comprehensive approach to address cross-continuum care transitions. This article will highlight key learnings from the Nurse Executive Center's research on achieving care continuity. The business case for developing a cross-continuum care transition strategy will be discussed, as well as systemic enablers for the achievement of seamless care. A case study example of 1 system's solution for supporting the multiple comorbid patient population as part of its cross-continuum care transition strategy will be examined.

49 CFR 178.925 - Standards for rigid plastic Large Packagings.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 3 2011-10-01 2011-10-01 false Standards for rigid plastic Large Packagings. 178... FOR PACKAGINGS Large Packagings Standards § 178.925 Standards for rigid plastic Large Packagings. (a) The provisions in this section apply to rigid plastic Large Packagings intended to contain liquids and...

49 CFR 178.925 - Standards for rigid plastic Large Packagings.

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 3 2012-10-01 2012-10-01 false Standards for rigid plastic Large Packagings. 178... FOR PACKAGINGS Large Packagings Standards § 178.925 Standards for rigid plastic Large Packagings. (a) The provisions in this section apply to rigid plastic Large Packagings intended to contain liquids and...

49 CFR 178.925 - Standards for rigid plastic Large Packagings.

Code of Federal Regulations, 2014 CFR

2014-10-01

... 49 Transportation 3 2014-10-01 2014-10-01 false Standards for rigid plastic Large Packagings. 178... FOR PACKAGINGS Large Packagings Standards § 178.925 Standards for rigid plastic Large Packagings. (a) The provisions in this section apply to rigid plastic Large Packagings intended to contain liquids and...

49 CFR 178.925 - Standards for rigid plastic Large Packagings.

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 3 2013-10-01 2013-10-01 false Standards for rigid plastic Large Packagings. 178... FOR PACKAGINGS Large Packagings Standards § 178.925 Standards for rigid plastic Large Packagings. (a) The provisions in this section apply to rigid plastic Large Packagings intended to contain liquids and...

Method and apparatus for providing a seamless tiled display

NASA Technical Reports Server (NTRS)

Dubin, Matthew B. (Inventor); Johnson, Michael J. (Inventor)

2002-01-01

A display for producing a seamless composite image from at least two discrete images. The display includes one or more projectors for projecting each of the discrete images separately onto a screen such that at least one of the discrete images overlaps at least one other of the discrete images by more than 25 percent. The amount of overlap that is required to reduce the seams of the composite image to an acceptable level over a predetermined viewing angle depends on a number of factors including the field-of-view and aperture size of the projectors, the screen gain profile, etc. For rear-projection screens and some front projection screens, an overlap of more than 25 percent is acceptable.

Research on Rigid Body Motion Tracing in Space based on NX MCD

NASA Astrophysics Data System (ADS)

Wang, Junjie; Dai, Chunxiang; Shi, Karen; Qin, Rongkang

2018-03-01

In the use of MCD (Mechatronics Concept Designer) which is a module belong to SIEMENS Ltd industrial design software UG (Unigraphics NX), user can define rigid body and kinematic joint to make objects move according to the existing plan in simulation. At this stage, user may have the desire to see the path of some points in the moving object intuitively. In response to this requirement, this paper will compute the pose through the transformation matrix which can be available from the solver engine, and then fit these sampling points through B-spline curve. Meanwhile, combined with the actual constraints of rigid bodies, the traditional equal interval sampling strategy was optimized. The result shown that this method could satisfy the demand and make up for the deficiency in traditional sampling method. User can still edit and model on this 3D curve. Expected result has been achieved.

Rigid body formulation in a finite element context with contact interaction

NASA Astrophysics Data System (ADS)

Refachinho de Campos, Paulo R.; Gay Neto, Alfredo

2018-03-01

The present work proposes a formulation to employ rigid bodies together with flexible bodies in the context of a nonlinear finite element solver, with contact interactions. Inertial contributions due to distribution of mass of a rigid body are fully developed, considering a general pole position associated with a single node, representing a rigid body element. Additionally, a mechanical constraint is proposed to connect a rigid region composed by several nodes, which is useful for linking rigid/flexible bodies in a finite element environment. Rodrigues rotation parameters are used to describe finite rotations, by an updated Lagrangian description. In addition, the contact formulation entitled master-surface to master-surface is employed in conjunction with the rigid body element and flexible bodies, aiming to consider their interaction in a rigid-flexible multibody environment. New surface parameterizations are presented to establish contact pairs, permitting pointwise interaction in a frictional scenario. Numerical examples are provided to show robustness and applicability of the methods.

Non-rigid image registration using graph-cuts.

PubMed

Tang, Tommy W H; Chung, Albert C S

2007-01-01

Non-rigid image registration is an ill-posed yet challenging problem due to its supernormal high degree of freedoms and inherent requirement of smoothness. Graph-cuts method is a powerful combinatorial optimization tool which has been successfully applied into image segmentation and stereo matching. Under some specific constraints, graph-cuts method yields either a global minimum or a local minimum in a strong sense. Thus, it is interesting to see the effects of using graph-cuts in non-rigid image registration. In this paper, we formulate non-rigid image registration as a discrete labeling problem. Each pixel in the source image is assigned a displacement label (which is a vector) indicating which position in the floating image it is spatially corresponding to. A smoothness constraint based on first derivative is used to penalize sharp changes in displacement labels across pixels. The whole system can be optimized by using the graph-cuts method via alpha-expansions. We compare 2D and 3D registration results of our method with two state-of-the-art approaches. It is found that our method is more robust to different challenging non-rigid registration cases with higher registration accuracy.

Fast and anisotropic flexibility-rigidity index for protein flexibility and fluctuation analysis

NASA Astrophysics Data System (ADS)

Opron, Kristopher; Xia, Kelin; Wei, Guo-Wei

2014-06-01

Protein structural fluctuation, typically measured by Debye-Waller factors, or B-factors, is a manifestation of protein flexibility, which strongly correlates to protein function. The flexibility-rigidity index (FRI) is a newly proposed method for the construction of atomic rigidity functions required in the theory of continuum elasticity with atomic rigidity, which is a new multiscale formalism for describing excessively large biomolecular systems. The FRI method analyzes protein rigidity and flexibility and is capable of predicting protein B-factors without resorting to matrix diagonalization. A fundamental assumption used in the FRI is that protein structures are uniquely determined by various internal and external interactions, while the protein functions, such as stability and flexibility, are solely determined by the structure. As such, one can predict protein flexibility without resorting to the protein interaction Hamiltonian. Consequently, bypassing the matrix diagonalization, the original FRI has a computational complexity of O(N^2). This work introduces a fast FRI (fFRI) algorithm for the flexibility analysis of large macromolecules. The proposed fFRI further reduces the computational complexity to O(N). Additionally, we propose anisotropic FRI (aFRI) algorithms for the analysis of protein collective dynamics. The aFRI algorithms permit adaptive Hessian matrices, from a completely global 3N × 3N matrix to completely local 3 × 3 matrices. These 3 × 3 matrices, despite being calculated locally, also contain non-local correlation information. Eigenvectors obtained from the proposed aFRI algorithms are able to demonstrate collective motions. Moreover, we investigate the performance of FRI by employing four families of radial basis correlation functions. Both parameter optimized and parameter-free FRI methods are explored. Furthermore, we compare the accuracy and efficiency of FRI with some established approaches to flexibility analysis, namely, normal

Fast and anisotropic flexibility-rigidity index for protein flexibility and fluctuation analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Opron, Kristopher; Xia, Kelin; Wei, Guo-Wei, E-mail: wei@math.msu.edu

Protein structural fluctuation, typically measured by Debye-Waller factors, or B-factors, is a manifestation of protein flexibility, which strongly correlates to protein function. The flexibility-rigidity index (FRI) is a newly proposed method for the construction of atomic rigidity functions required in the theory of continuum elasticity with atomic rigidity, which is a new multiscale formalism for describing excessively large biomolecular systems. The FRI method analyzes protein rigidity and flexibility and is capable of predicting protein B-factors without resorting to matrix diagonalization. A fundamental assumption used in the FRI is that protein structures are uniquely determined by various internal and external interactions,more » while the protein functions, such as stability and flexibility, are solely determined by the structure. As such, one can predict protein flexibility without resorting to the protein interaction Hamiltonian. Consequently, bypassing the matrix diagonalization, the original FRI has a computational complexity of O(N{sup 2}). This work introduces a fast FRI (fFRI) algorithm for the flexibility analysis of large macromolecules. The proposed fFRI further reduces the computational complexity to O(N). Additionally, we propose anisotropic FRI (aFRI) algorithms for the analysis of protein collective dynamics. The aFRI algorithms permit adaptive Hessian matrices, from a completely global 3N × 3N matrix to completely local 3 × 3 matrices. These 3 × 3 matrices, despite being calculated locally, also contain non-local correlation information. Eigenvectors obtained from the proposed aFRI algorithms are able to demonstrate collective motions. Moreover, we investigate the performance of FRI by employing four families of radial basis correlation functions. Both parameter optimized and parameter-free FRI methods are explored. Furthermore, we compare the accuracy and efficiency of FRI with some established approaches to flexibility analysis

Surveying and Modeling Students' Motivation and Learning Strategies for Mobile-Assisted Seamless Chinese Language Learning

ERIC Educational Resources Information Center

Chai, Ching Sing; Wong, Lung-Hsiang; King, Ronnel B.

2016-01-01

Seamless language learning promises to be an effective learning approach that addresses the limitations of classroom-only language learning. It leverages mobile technologies to facilitate holistic and perpetual learning experiences that bridge different locations, times, technologies or social settings. Despite the emergence of studies on seamless…

Rigidity of transmembrane proteins determines their cluster shape

NASA Astrophysics Data System (ADS)

Jafarinia, Hamidreza; Khoshnood, Atefeh; Jalali, Mir Abbas

2016-01-01

Protein aggregation in cell membrane is vital for the majority of biological functions. Recent experimental results suggest that transmembrane domains of proteins such as α -helices and β -sheets have different structural rigidities. We use molecular dynamics simulation of a coarse-grained model of protein-embedded lipid membranes to investigate the mechanisms of protein clustering. For a variety of protein concentrations, our simulations under thermal equilibrium conditions reveal that the structural rigidity of transmembrane domains dramatically affects interactions and changes the shape of the cluster. We have observed stable large aggregates even in the absence of hydrophobic mismatch, which has been previously proposed as the mechanism of protein aggregation. According to our results, semiflexible proteins aggregate to form two-dimensional clusters, while rigid proteins, by contrast, form one-dimensional string-like structures. By assuming two probable scenarios for the formation of a two-dimensional triangular structure, we calculate the lipid density around protein clusters and find that the difference in lipid distribution around rigid and semiflexible proteins determines the one- or two-dimensional nature of aggregates. It is found that lipids move faster around semiflexible proteins than rigid ones. The aggregation mechanism suggested in this paper can be tested by current state-of-the-art experimental facilities.

The treatment of loss of penile rigidity associated with Peyronie's disease.

PubMed

Krane, R J

1996-01-01

Patients with Peyronie's Disease on occasion present with loss of rigid erections. A full evaluation is required to determine the presence or absence of arterial insufficiency or corporal veno-occlusive dysfunction. Treatment for these patients include intracavernosal pharmacotherapy, a vacuum/constrictor device, venous ligation surgery or a penile prosthesis. Whatever the therapeutic approach, the angulation produced by the Peyronie's plaque must be taken into account. Patients with Peyronie's Disease will present to their physicians with a variety of clinical scenarios. They may merely be concerned with the presence of an asymptomatic penile plaque and will simply require reassurance. More typically, however, penile curvature, pain, and/or difficulty with sexual relations will prompt the desire for medical advice. Treatment of penile pain which usually abates with time and attempts at non surgically treating the Peyronies plaque will not be discussed in this paper. Patients with penile plaque and curvature present in three distinct ways: a. penile rigidity preserved and the ability to continue sexual relations; b, penile rigidity preserved and the inability to continue with sexual relations because of significant angulation; c. the inability to have rigid erections. The patient who is able to continue sexual relations with preserved penile rigidity and the lack of significant penile angulation requires no treatment. However, the patient who has lost his ability to have sexual relations because of significant angulation is a candidate for penile straightening surgery (e.g. graft) (1, 11). It is the last group of patients. Namely those who are not able to maintain penile rigidity because of their Peyronie's Disease that will be addressed in this paper. Patients who present with impotence (i.e. loss of penile rigidity) and Peyronie's disease should be evaluated in a similar manner as patients who present with erectile dysfunction and do not have Peyronie's Disease

Rigid-Cluster Models of Conformational Transitions in Macromolecular Machines and Assemblies

PubMed Central

Kim, Moon K.; Jernigan, Robert L.; Chirikjian, Gregory S.

2005-01-01

We present a rigid-body-based technique (called rigid-cluster elastic network interpolation) to generate feasible transition pathways between two distinct conformations of a macromolecular assembly. Many biological molecules and assemblies consist of domains which act more or less as rigid bodies during large conformational changes. These collective motions are thought to be strongly related with the functions of a system. This fact encourages us to simply model a macromolecule or assembly as a set of rigid bodies which are interconnected with distance constraints. In previous articles, we developed coarse-grained elastic network interpolation (ENI) in which, for example, only Cα atoms are selected as representatives in each residue of a protein. We interpolate distance differences of two conformations in ENI by using a simple quadratic cost function, and the feasible conformations are generated without steric conflicts. Rigid-cluster interpolation is an extension of the ENI method with rigid-clusters replacing point masses. Now the intermediate conformations in an anharmonic pathway can be determined by the translational and rotational displacements of large clusters in such a way that distance constraints are observed. We present the derivation of the rigid-cluster model and apply it to a variety of macromolecular assemblies. Rigid-cluster ENI is then modified for a hybrid model represented by a mixture of rigid clusters and point masses. Simulation results show that both rigid-cluster and hybrid ENI methods generate sterically feasible pathways of large systems in a very short time. For example, the HK97 virus capsid is an icosahedral symmetric assembly composed of 60 identical asymmetric units. Its original Hessian matrix size for a Cα coarse-grained model is >(300,000)2. However, it reduces to (84)2 when we apply the rigid-cluster model with icosahedral symmetry constraints. The computational cost of the interpolation no longer scales heavily with the size

Seamless hydrological predictions for a monsoon driven catchment in North-East India

NASA Astrophysics Data System (ADS)

Köhn, Lisei; Bürger, Gerd; Bronstert, Axel

2016-04-01

Improving hydrological forecasting systems on different time scales is interesting and challenging with regards to humanitarian as well as scientific aspects. In meteorological research, short-, medium-, and long-term forecasts are now being merged to form a system of seamless weather and climate predictions. Coupling of these meteorological forecasts with a hydrological model leads to seamless predictions of streamflow, ranging from one day to a season. While there are big efforts made to analyse the uncertainties of probabilistic streamflow forecasts, knowledge of the single uncertainty contributions from meteorological and hydrological modeling is still limited. The overarching goal of this project is to gain knowledge in this subject by decomposing and quantifying the overall predictive uncertainty into its single factors for the entire seamless forecast horizon. Our study area is the Mahanadi River Basin in North-East India, which is prone to severe floods and droughts. Improved streamflow forecasts on different time scales would contribute to early flood warning as well as better water management operations in the agricultural sector. Because of strong inter-annual monsoon variations in this region, which are, unlike the mid-latitudes, partly predictable from long-term atmospheric-oceanic oscillations, the Mahanadi catchment represents an ideal study site. Regionalized precipitation forecasts are obtained by applying the method of expanded downscaling to the ensemble prediction systems of ECMWF and NCEP. The semi-distributed hydrological model HYPSO-RR, which was developed in the Eco-Hydrological Simulation Environment ECHSE, is set up for several sub-catchments of the Mahanadi River Basin. The model is calibrated automatically using the Dynamically Dimensioned Search algorithm, with a modified Nash-Sutcliff efficiency as objective function. Meteorological uncertainty is estimated from the existing ensemble simulations, while the hydrological uncertainty is

The problem of exact interior solutions for rotating rigid bodies in general relativity

NASA Technical Reports Server (NTRS)

Wahlquist, H. D.

1993-01-01

The (3 + 1) dyadic formalism for timelike congruences is applied to derive interior solutions for stationary, axisymmetric, rigidly rotating bodies. In this approach the mathematics is formulated in terms of three-space-covariant, first-order, vector-dyadic, differential equations for a and Omega, the acceleration and angular velocity three-vectors of the rigid body; for T, the stress dyadic of the matter; and for A and B, the 'electric' and 'magnetic' Weyl curvature dyadics which describe the gravitational field. It is shown how an appropriate ansatz for the forms of these dyadics can be used to discover exact rotating interior solutions such as the perfect fluid solution first published in 1968. By incorporating anisotropic stresses, a generalization is found of that previous solution and, in addition, a very simple new solution that can only exist in toroidal configurations.

21 CFR 890.3610 - Rigid pneumatic structure orthosis.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Rigid pneumatic structure orthosis. 890.3610 Section 890.3610 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3610 Rigid...

21 CFR 890.3610 - Rigid pneumatic structure orthosis.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Rigid pneumatic structure orthosis. 890.3610 Section 890.3610 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3610 Rigid...

21 CFR 890.3610 - Rigid pneumatic structure orthosis.

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Rigid pneumatic structure orthosis. 890.3610 Section 890.3610 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3610 Rigid...

21 CFR 890.3610 - Rigid pneumatic structure orthosis.

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Rigid pneumatic structure orthosis. 890.3610 Section 890.3610 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3610 Rigid...

21 CFR 890.3610 - Rigid pneumatic structure orthosis.

Code of Federal Regulations, 2014 CFR

2014-04-01

... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Rigid pneumatic structure orthosis. 890.3610 Section 890.3610 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES PHYSICAL MEDICINE DEVICES Physical Medicine Prosthetic Devices § 890.3610 Rigid...

Flexible band versus rigid ring annuloplasty for functional tricuspid regurgitation

PubMed Central

Izutani, Hironori; Nakamura, Teruya; Kawachi, Kanji

2010-01-01

We review and compare our experience with tricuspid ring annuloplasty between usage of the Cosgrove-Edwards flexible band and the MC3 rigid ring for repair of functional tricuspid regurgitation to determine the efficacy and mid-term durability of tricuspid annuloplasty. 117 patients with functional tricuspid regurgitation undergoing open heart surgery and tricuspid valve repair from May 2005 to December 2007 were reviewed. The flexible bands were used in thirty five patients before October 2006. Since then, the rigid rings were used in the next consecutive eighty two cases. Echocardiographic evaluation of tricuspid regurgitation was performed preoperatively and postoperatively in follow-up schedule. The degree of tricuspid regurgitation was reduced from 2.80±0.67 to 0.71±1.0 (regurgitation severity grade: 0 to 4) in the patients with flexible bands at discharge. It was from 2.68±0.70 to 0.22±0.60 in the patients with rigid rings. At thirty six months postoperative period, tricuspid regurgitation grades in patients with flexible bands and rigid rings were 0.80±0.95 and 0.36±0.77, respectively. Freedom from recurrent tricuspid regurgitation (grade 2 or 3) in patients with flexible bands and rigid rings were 68.6% and 87.8%, respectively. Recurrent tricuspid regurgitation was significantly lower in the patients with rigid rings. Although both flexible band and rigid ring annuloplasty provide low rate of recurrent tricuspid regurgitation, rigid ring annuloplasty might be more effective than flexible band annuloplasty for decreasing functional tricuspid regurgitation in immediate and mid-term postoperative periods. PMID:21977298

A probabilistic model for detecting rigid domains in protein structures.

PubMed

Nguyen, Thach; Habeck, Michael

2016-09-01

Large-scale conformational changes in proteins are implicated in many important biological functions. These structural transitions can often be rationalized in terms of relative movements of rigid domains. There is a need for objective and automated methods that identify rigid domains in sets of protein structures showing alternative conformational states. We present a probabilistic model for detecting rigid-body movements in protein structures. Our model aims to approximate alternative conformational states by a few structural parts that are rigidly transformed under the action of a rotation and a translation. By using Bayesian inference and Markov chain Monte Carlo sampling, we estimate all parameters of the model, including a segmentation of the protein into rigid domains, the structures of the domains themselves, and the rigid transformations that generate the observed structures. We find that our Gibbs sampling algorithm can also estimate the optimal number of rigid domains with high efficiency and accuracy. We assess the power of our method on several thousand entries of the DynDom database and discuss applications to various complex biomolecular systems. The Python source code for protein ensemble analysis is available at: https://github.com/thachnguyen/motion_detection : mhabeck@gwdg.de. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Political conservatism, rigidity, and dogmatism in American foreign policy officials: the 1966 Mennis data.

PubMed

Kemmelmeier, Markus

2007-01-01

Researchers have established a relationship between political orientation and cognitive styles (A. Chirumbolo, 2002; J. T. Jost, J. Glaser, A. W. Kruglanski, & F. Sulloway, 2003a, 2003b; M. Kemmelmeier, 1997). In this article, the author examined whether this finding is true in the political elite, whether the relationship is linear or curvilinear, and whether interest in politics moderates the relationship between political orientation and cognitive styles. He used a 1966 sample of American foreign policy officials (N = 95) to examine the relationship between self-described conservatism and party identification and individual differences in rigidity and dogmatism. Rigidity was related to self-described conservatism, but this relationship was only significant among participants high in political interest, whereas dogmatism was unconditionally related to party identification. All relationships were linear and did not contain a curvilinear component.

Evolution of microstructure in stainless martensitic steel for seamless tubing

NASA Astrophysics Data System (ADS)

Pyshmintsev, I. Yu.; Bityukov, S. M.; Pastukhov, V. I.; Danilov, S. V.; Vedernikova, L. O.; Lobanov, M. L.

2017-12-01

Scanning electron microscopy with orientation analysis by the electron backscatter diffraction (EBSD) method is used to study microstructures and textures formed in the 0.08C-13Cr-3Ni-Mo-V-Nb steel through seamless tube production route: after hot deformation by extrusion; after quenching from various temperatures and subsequent high tempering. It is shown that the martensitic microstructure formed both after hot deformation and after quenching is characterized by the presence of deformation crystallographic texture, which is predetermined by the texture of austenite. The effect of heat treatment on texture, packet refinement, lath width, precipitation of carbides and Charpy impact energy is analyzed.

A New Seamless Transfer Control Strategy of the Microgrid

PubMed Central

Zhang, Zhaoyun; Chen, Wei; Zhang, Zhe

2014-01-01

A microgrid may operate under two typical modes; the seamless transfer control of the microgrid is very important. The mode conversion controller is installed in microgrid and the control logic of master power is optimized for microgrid mode conversion. In the proposed scheme, master power is very important. The master-power is under the PQ control when microgrid is under grid-connected. And it is under V/F control when the microgrid is under islanding. The microgrid mode controller is used to solve the planned conversion. Three types of conversion are simulated in this paper. The simulation results show the correctness and validity of the mode control scheme. Finally, the implementation and application of the operation and control device are described. PMID:24967431

A new seamless transfer control strategy of the microgrid.

PubMed

Zhang, Zhaoyun; Chen, Wei; Zhang, Zhe

2014-01-01

A microgrid may operate under two typical modes; the seamless transfer control of the microgrid is very important. The mode conversion controller is installed in microgrid and the control logic of master power is optimized for microgrid mode conversion. In the proposed scheme, master power is very important. The master-power is under the PQ control when microgrid is under grid-connected. And it is under V/F control when the microgrid is under islanding. The microgrid mode controller is used to solve the planned conversion. Three types of conversion are simulated in this paper. The simulation results show the correctness and validity of the mode control scheme. Finally, the implementation and application of the operation and control device are described.

Rigid Body Motion in Stereo 3D Simulation

ERIC Educational Resources Information Center

Zabunov, Svetoslav

2010-01-01

This paper addresses the difficulties experienced by first-grade students studying rigid body motion at Sofia University. Most quantities describing the rigid body are in relations that the students find hard to visualize and understand. They also lose the notion of cause-result relations between vector quantities, such as the relation between…

High-quality seamless DEM generation blending SRTM-1, ASTER GDEM v2 and ICESat/GLAS observations

NASA Astrophysics Data System (ADS)

Yue, Linwei; Shen, Huanfeng; Zhang, Liangpei; Zheng, Xianwei; Zhang, Fan; Yuan, Qiangqiang

2017-01-01

The absence of a high-quality seamless global digital elevation model (DEM) dataset has been a challenge for the Earth-related research fields. Recently, the 1-arc-second Shuttle Radar Topography Mission (SRTM-1) data have been released globally, covering over 80% of the Earth's land surface (60°N-56°S). However, voids and anomalies still exist in some tiles, which has prevented the SRTM-1 dataset from being directly used without further processing. In this paper, we propose a method to generate a seamless DEM dataset blending SRTM-1, ASTER GDEM v2, and ICESat laser altimetry data. The ASTER GDEM v2 data are used as the elevation source for the SRTM void filling. To get a reliable filling source, ICESat GLAS points are incorporated to enhance the accuracy of the ASTER data within the void regions, using an artificial neural network (ANN) model. After correction, the voids in the SRTM-1 data are filled with the corrected ASTER GDEM values. The triangular irregular network based delta surface fill (DSF) method is then employed to eliminate the vertical bias between them. Finally, an adaptive outlier filter is applied to all the data tiles. The final result is a seamless global DEM dataset. ICESat points collected from 2003 to 2009 were used to validate the effectiveness of the proposed method, and to assess the vertical accuracy of the global DEM products in China. Furthermore, channel networks in the Yangtze River Basin were also extracted for the data assessment.

Auxetic behaviour from rotating rigid units

NASA Astrophysics Data System (ADS)

Grima, J. N.; Alderson, A.; Evans, K. E.

2005-03-01

Auxetic materials exhibit the unexpected feature of becoming fatter when stretched and narrower when compressed, in other words, they exhibit a negative Poisson's ratio. This counter-intuitive behaviour imparts many beneficial effects on the material's macroscopic properties that make auxetics superior to conventional materials in many commercial applications. Recent research suggests that auxetic be-haviour generally results from a cooperative effect between the material's internal structure (geometry setup) and the deformation mechanism it undergoes when submitted to a stress. Auxetic behaviour is also known to be scale-independent, and thus, the same geometry/deformation mechanism may operate at the macro-, micro- and nano- (molecular) level. A considerable amount of research has been focused on the re-entrant honeycomb structure which exhibits auxetic behaviour if deformed through hinging at the joints or flexure of the ribs, and it was proposed that this re-entrant geometry plays an impor- tant role in generating auxetic behaviour in various forms of materials ranging from nanostructured polymers to foams. This paper discusses an alternative mode of deformation involving rotating rigid units which also results in negative Poisson's ratios. In its most ideal form, this mechanism may be construc- ted in two dimensions using rigid polygons connected together through hinges at their vertices. On application of uniaxial loads, these rigid polygons rotate with respect to each other to form a more open structure hence giving rise to a negative Poisson's ratio. This paper also discusses the role that rotating rigid units are thought to have in various classes of materials to give rise to negative Poisson's ratios.

77 FR 54926 - Certain Seamless Carbon and Alloy Steel; Standard, Line, and Pressure Pipe From Germany

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-06

... INTERNATIONAL TRADE COMMISSION [Investigation No. 731-TA-709 (Third Review)] Certain Seamless Carbon and Alloy Steel; Standard, Line, and Pressure Pipe From Germany Determination On the basis of the record \\1\\ developed in the subject five-year review, the United States International Trade Commission...

High Resolution Quantification of Cellular Forces for Rigidity Sensing

NASA Astrophysics Data System (ADS)

Liu, Shuaimin

This thesis describes a comprehensive study of understanding the mechanism of rigidity sensing by quantitative analysis using submicron pillar array substrates. From mechanobiology perspective, we explore and study molecular pathways involved in rigidity and force sensing at cell-matrix adhesions with regard to cancer, regeneration, and development by quantification methods. In Chapter 2 and 3, we developed fabrication and imaging techniques to enhance the performance of a submicron pillar device in terms of spatial and temporal measurement ability, and we discovered a correlation of rigidity sensing forces and corresponding proteins involved in the early rigidity sensing events. In Chapter 2, we introduced optical effect arising from submicron structure imaging, and we described a technique to identify the correct focal plane of pillar tip by fabricating a substrate with designed-offset pillars. From calibration result, we identified the correct focal plane that was previously overlooked, and verified our findings by other imaging techniques. In Chapter 3, we described several techniques to selectively functionalize elastomeric pillars top and compared these techniques in terms of purposes and fabrication complexity. Techniques introduced in this chapter included direct labeling, such as stamping of fluorescent substances (organic dye, nano-diamond, q-dot) to pillars top, as well as indirect labeling that selectively modify the surface of molds with either metal or fluorescent substances. In Chapter 4, we examined the characteristics of local contractility forces and identified the components formed a sarcomere like contractile unit (CU) that cells use to sense rigidity. CUs were found to be assembled at cell edge, contain myosin II, alpha-actinin, tropomodulin and tropomyosin (Tm), and resemble sarcomeres in size (˜2 mum) and function. Then we performed quantitative analysis of CUs to evaluate rigidity sensing activity over ˜8 hours time course and found that

Construction of the Non-Rigid Earth Rotation Series

NASA Astrophysics Data System (ADS)

Pashkevich, V. V.

2007-01-01

Last years a lot of attempts to derive a high-precision theory of the non-rigid Earth rotation are carried out. For these purposes different transfer functions are used. Usually these transfer functions are applied to the series representing the nutation in the longitude and the obliquity of the rigid Earth rotation with respect to the ecliptic of date. The aim of this investigation is a construction of new high-precision non-rigid Earth rotation series (SN9000), dynamically adequate to the DE404/LE404 ephemeris over 2000 time span years, which are presented as functions of the Euler angles Ψ, θ and φ with respect to the fixed ecliptic plane and equinox J2000.0.

Rigidity of outermost MOTS: the initial data version

NASA Astrophysics Data System (ADS)

Galloway, Gregory J.

2018-03-01

In the paper Commun Anal Geom 16(1):217-229, 2008, a rigidity result was obtained for outermost marginally outer trapped surfaces (MOTSs) that do not admit metrics of positive scalar curvature. This allowed one to treat the "borderline case" in the author's work with R. Schoen concerning the topology of higher dimensional black holes (Commun Math Phys 266(2):571-576, 2006). The proof of this rigidity result involved bending the initial data manifold in the vicinity of the MOTS within the ambient spacetime. In this note we show how to circumvent this step, and thereby obtain a pure initial data version of this rigidity result and its consequence concerning the topology of black holes.

Seamless editing of the chloroplast genome in plants.

PubMed

Martin Avila, Elena; Gisby, Martin F; Day, Anil

2016-07-29

Gene editing technologies enable the precise insertion of favourable mutations and performance enhancing trait genes into chromosomes whilst excluding all excess DNA from modified genomes. The technology gives rise to a new class of biotech crops which is likely to have widespread applications in agriculture. Despite progress in the nucleus, the seamless insertions of point mutations and non-selectable foreign genes into the organelle genomes of crops have not been described. The chloroplast genome is an attractive target to improve photosynthesis and crop performance. Current chloroplast genome engineering technologies for introducing point mutations into native chloroplast genes leave DNA scars, such as the target sites for recombination enzymes. Seamless editing methods to modify chloroplast genes need to address reversal of site-directed point mutations by template mediated repair with the vast excess of wild type chloroplast genomes that are present early in the transformation process. Using tobacco, we developed an efficient two-step method to edit a chloroplast gene by replacing the wild type sequence with a transient intermediate. This was resolved to the final edited gene by recombination between imperfect direct repeats. Six out of 11 transplastomic plants isolated contained the desired intermediate and at the second step this was resolved to the edited chloroplast gene in five of six plants tested. Maintenance of a single base deletion mutation in an imperfect direct repeat of the native chloroplast rbcL gene showed the limited influence of biased repair back to the wild type sequence. The deletion caused a frameshift, which replaced the five C-terminal amino acids of the Rubisco large subunit with 16 alternative residues resulting in a ~30-fold reduction in its accumulation. We monitored the process in vivo by engineering an overlapping gusA gene downstream of the edited rbcL gene. Translational coupling between the overlapping rbcL and gusA genes

Utility of semi-rigid thoracoscopy in undiagnosed exudative pleural effusion.

PubMed

Nattusamy, Loganathan; Madan, Karan; Mohan, Anant; Hadda, Vijay; Jain, Deepali; Madan, Neha Kawatra; Arava, Sudheer; Khilnani, Gopi C; Guleria, Randeep

2015-01-01

Semi-rigid thoracoscopy is a safe and efficacious procedure in patients with undiagnosed pleural effusion. Literature on its utility from developing countries is limited. We herein describe our initial experience on the utility of semi-rigid thoracoscopy from a tertiary care teaching and referral center in north India. We also perform a systematic review of studies reporting the utility of semi-rigid thoracoscopy from India. The primary objective was to evaluate the diagnostic utility of semi-rigid thoracoscopy in patients with undiagnosed exudative pleural effusion. Semi-rigid thoracoscopy was performed under local anesthesia and conscious sedation in the bronchoscopy suite. A total of 48 patients underwent semi-rigid thoracoscopy between August 2012 and December 2013 for undiagnosed pleural effusion. Mean age was 50.9 ± 14.1 years (range: 17-78 years). Pre-procedure clinico-radiological diagnoses were malignant pleural effusion [36 patients (75%)], tuberculosis (TB) [10 (20.83%) patients], and empyema [2 patients (4.17%)]. Patients with empyema underwent the procedure for pleural biopsy, optimal placement of intercostal tube and adhesiolysis. Thoracoscopic pleural biopsy diagnosed pleural malignancy in 30 (62.5%) patients and TB in 2 (4.17%) patients. Fourteen (29.17%) patients were diagnosed with non-specific pleuritis and normal pleura was diagnosed on a pleural biopsy in 2 (4.17%) patients. Overall, a definitive diagnosis of either pleural malignancy or TB was obtained in 32 (66.7%) patients. Combined overall sensitivity, specificity, positive predictive value and negative predictive value of thoracoscopic pleural biopsy for malignant pleural effusion were 96.77%, 100%, 100% and 66.67%, respectively. There was no procedure-related mortality. On performing a systematic review of literature, four studies on semi-rigid thoracoscopy from India were identified. Semi-rigid thoracoscopy is a safe and efficacious procedure in patients with undiagnosed exudative

Utility of semi-rigid thoracoscopy in undiagnosed exudative pleural effusion

PubMed Central

Nattusamy, Loganathan; Madan, Karan; Mohan, Anant; Hadda, Vijay; Jain, Deepali; Madan, Neha Kawatra; Arava, Sudheer; Khilnani, Gopi C; Guleria, Randeep

2015-01-01

Background: Semi-rigid thoracoscopy is a safe and efficacious procedure in patients with undiagnosed pleural effusion. Literature on its utility from developing countries is limited. We herein describe our initial experience on the utility of semi-rigid thoracoscopy from a tertiary care teaching and referral center in north India. We also perform a systematic review of studies reporting the utility of semi-rigid thoracoscopy from India. Patients and Methods: The primary objective was to evaluate the diagnostic utility of semi-rigid thoracoscopy in patients with undiagnosed exudative pleural effusion. Semi-rigid thoracoscopy was performed under local anesthesia and conscious sedation in the bronchoscopy suite. Results: A total of 48 patients underwent semi-rigid thoracoscopy between August 2012 and December 2013 for undiagnosed pleural effusion. Mean age was 50.9 ± 14.1 years (range: 17–78 years). Pre-procedure clinico-radiological diagnoses were malignant pleural effusion [36 patients (75%)], tuberculosis (TB) [10 (20.83%) patients], and empyema [2 patients (4.17%)]. Patients with empyema underwent the procedure for pleural biopsy, optimal placement of intercostal tube and adhesiolysis. Thoracoscopic pleural biopsy diagnosed pleural malignancy in 30 (62.5%) patients and TB in 2 (4.17%) patients. Fourteen (29.17%) patients were diagnosed with non-specific pleuritis and normal pleura was diagnosed on a pleural biopsy in 2 (4.17%) patients. Overall, a definitive diagnosis of either pleural malignancy or TB was obtained in 32 (66.7%) patients. Combined overall sensitivity, specificity, positive predictive value and negative predictive value of thoracoscopic pleural biopsy for malignant pleural effusion were 96.77%, 100%, 100% and 66.67%, respectively. There was no procedure-related mortality. On performing a systematic review of literature, four studies on semi-rigid thoracoscopy from India were identified. Conclusion: Semi-rigid thoracoscopy is a safe and

Seamless Modeling for Research & Predictability of Severe Tropical Storms from Weather-to-Climate Timescales

NASA Astrophysics Data System (ADS)

Ramaswamy, V.; Chen, J. H.; Delworth, T. L.; Knutson, T. R.; Lin, S. J.; Murakami, H.; Vecchi, G. A.

2017-12-01

Damages from catastrophic tropical storms such as the 2017 destructive hurricanes compel an acceleration of scientific advancements to understand the genesis, underlying mechanisms, frequency, track, intensity, and landfall of these storms. The advances are crucial to provide improved early information for planners and responders. We discuss the development and utilization of a global modeling capability based on a novel atmospheric dynamical core ("Finite-Volume Cubed Sphere or FV3") which captures the realism of the recent tropical storms and is a part of the NOAA Next-Generation Global Prediction System. This capability is also part of an emerging seamless modeling system at NOAA/ Geophysical Fluid Dynamics Laboratory for simulating the frequency of storms on seasonal and longer timescales with high fidelity e.g., Atlantic hurricane frequency over the past decades. In addition, the same modeling system has also been employed to evaluate the nature of projected storms on the multi-decadal scales under the influence of anthropogenic factors such as greenhouse gases and aerosols. The seamless modeling system thus facilitates research into and the predictability of severe tropical storms across diverse timescales of practical interest to several societal sectors.

EAARL coastal topography-western Florida, post-Hurricane Charley, 2004: seamless (bare earth and submerged.

USGS Publications Warehouse

Nayegandhi, Amar; Bonisteel, Jamie M.; Wright, C. Wayne; Sallenger, A.H.; Brock, John C.; Yates, Xan

2010-01-01

processed using the Airborne Lidar Processing System (ALPS), a custom-built processing system developed in a NASA-USGS collaboration. ALPS supports the exploration and processing of lidar data in an interactive or batch mode. Modules for presurvey flight-line definition, flight-path plotting, lidar raster and waveform investigation, and digital camera image playback have been developed. Processing algorithms have been developed to extract the range to the first and last significant return within each waveform. ALPS is used routinely to create maps that represent submerged or sub-aerial topography. Specialized filtering algorithms have been implemented to determine the 'bare earth' under vegetation. For more information about similar projects, please visit the Decision Support for Coastal Science and Management website. Selected References Brock, J.C., Wright, C.W., Sallenger, A.H., Krabill, W.B., and Swift, R.N., 2002, Basis and methods of NASA airborne topographic mapper Lidar surveys for coastal studies: Journal of Coastal Research, v. 18, no. 1, p. 1-13. Crane, Michael, Clayton, Tonya, Raabe, Ellen, Stoker, Jason, Handley, Larry, Bawden, Gerald, Morgan, Karen, and Queija, Vivian, 2004, Report of the U.S. Geological Survey Lidar workshop sponsored by the Land Remote Sensing Program and held in St. Petersburg, FL, November 2002: U.S. Geological Survey Open-File Report 2004-1456, 72 p. Nayegandhi, Amar, Brock, J.C., and Wright, C.W., 2009, Small-footprint, waveform-resolving Lidar estimation of submerged and sub-canopy topography in coastal environments: International Journal of Remote Sensing, v. 30, no. 4, p. 861-878. Sallenger, A.H., Wright, C.W., and Lillycrop, Jeff, 2005, Coastal impacts of the 2004 hurricanes measured with airborne Lidar; initial results: Shore and Beach, v. 73, nos. 2-3, p. 10-14. Resources Included Readme.txt File

Hermes: Seamless delivery of containerized bioinformatics workflows in hybrid cloud (HTC) environments

NASA Astrophysics Data System (ADS)

Kintsakis, Athanassios M.; Psomopoulos, Fotis E.; Symeonidis, Andreas L.; Mitkas, Pericles A.

Hermes introduces a new "describe once, run anywhere" paradigm for the execution of bioinformatics workflows in hybrid cloud environments. It combines the traditional features of parallelization-enabled workflow management systems and of distributed computing platforms in a container-based approach. It offers seamless deployment, overcoming the burden of setting up and configuring the software and network requirements. Most importantly, Hermes fosters the reproducibility of scientific workflows by supporting standardization of the software execution environment, thus leading to consistent scientific workflow results and accelerating scientific output.

An Integrated Multi-layer Approach for Seamless Soft Handoff in Mobile Ad Hoc Networks

DTIC Science & Technology

2011-01-01

network to showcase how to leverage the IEEE 802.21 Media Independent Handover ( MIH ) framework [3] in our handoff solution. Moreover, to further...to the seamless handoff problem. The architecture leverages the IEEE 802.21 MIH standard to facilitate handover related decisions on multiple...provided by the MIH function (MIHF), the topology control manager dynamically activates/deactivates the wireless interfaces to ensure the network is

Supporting Seamless Mobility for P2P Live Streaming

PubMed Central

Kim, Eunsam; Kim, Sangjin; Lee, Choonhwa

2014-01-01

With advent of various mobile devices with powerful networking and computing capabilities, the users' demand to enjoy live video streaming services such as IPTV with mobile devices has been increasing rapidly. However, it is challenging to get over the degradation of service quality due to data loss caused by the handover. Although many handover schemes were proposed at protocol layers below the application layer, they inherently suffer from data loss while the network is being disconnected during the handover. We therefore propose an efficient application-layer handover scheme to support seamless mobility for P2P live streaming. By simulation experiments, we show that the P2P live streaming system with our proposed handover scheme can improve the playback continuity significantly compared to that without our scheme. PMID:24977171

21 CFR 874.4710 - Esophagoscope (flexible or rigid) and accessories.

Code of Federal Regulations, 2011 CFR

2011-04-01

... generic type of device includes the flexible foreign body claw, flexible biopsy forceps, rigid biopsy curette, flexible biopsy brush, rigid biopsy forceps and flexible biopsy curette, but excludes the...

21 CFR 874.4710 - Esophagoscope (flexible or rigid) and accessories.

Code of Federal Regulations, 2010 CFR

2010-04-01

... generic type of device includes the flexible foreign body claw, flexible biopsy forceps, rigid biopsy curette, flexible biopsy brush, rigid biopsy forceps and flexible biopsy curette, but excludes the...

21 CFR 874.4760 - Nasopharyngoscope (flexible or rigid) and accessories.

Code of Federal Regulations, 2014 CFR

2014-04-01

..., salpingoscope, flexible foreign body claw, flexible biopsy forceps, rigid biopsy curette, flexible biospy brush, rigid biopsy forceps and flexible biopsy curette, but excludes the fiberoptic light source and carrier...

21 CFR 874.4760 - Nasopharyngoscope (flexible or rigid) and accessories.

Code of Federal Regulations, 2013 CFR

2013-04-01

..., salpingoscope, flexible foreign body claw, flexible biopsy forceps, rigid biopsy curette, flexible biospy brush, rigid biopsy forceps and flexible biopsy curette, but excludes the fiberoptic light source and carrier...

21 CFR 874.4760 - Nasopharyngoscope (flexible or rigid) and accessories.

Code of Federal Regulations, 2012 CFR

2012-04-01

..., salpingoscope, flexible foreign body claw, flexible biopsy forceps, rigid biopsy curette, flexible biospy brush, rigid biopsy forceps and flexible biopsy curette, but excludes the fiberoptic light source and carrier...

Bending Rigidity of 2D Silica.

PubMed

Büchner, C; Eder, S D; Nesse, T; Kuhness, D; Schlexer, P; Pacchioni, G; Manson, J R; Heyde, M; Holst, B; Freund, H-J

2018-06-01

A chemically stable bilayers of SiO_{2} (2D silica) is a new, wide band gap 2D material. Up till now graphene has been the only 2D material where the bending rigidity has been measured. Here we present inelastic helium atom scattering data from 2D silica on Ru(0001) and extract the first bending rigidity, κ, measurements for a nonmonoatomic 2D material of definable thickness. We find a value of κ=8.8  eV±0.5  eV which is of the same order of magnitude as theoretical values in the literature for freestanding crystalline 2D silica.

Bending Rigidity of 2D Silica

NASA Astrophysics Data System (ADS)

Büchner, C.; Eder, S. D.; Nesse, T.; Kuhness, D.; Schlexer, P.; Pacchioni, G.; Manson, J. R.; Heyde, M.; Holst, B.; Freund, H.-J.

2018-06-01

A chemically stable bilayers of SiO2 (2D silica) is a new, wide band gap 2D material. Up till now graphene has been the only 2D material where the bending rigidity has been measured. Here we present inelastic helium atom scattering data from 2D silica on Ru(0001) and extract the first bending rigidity, κ , measurements for a nonmonoatomic 2D material of definable thickness. We find a value of κ =8.8 eV ±0.5 eV which is of the same order of magnitude as theoretical values in the literature for freestanding crystalline 2D silica.

Underwater sound of rigid-hulled inflatable boats.

PubMed

Erbe, Christine; Liong, Syafrin; Koessler, Matthew Walter; Duncan, Alec J; Gourlay, Tim

2016-06-01

Underwater sound of rigid-hulled inflatable boats was recorded 142 times in total, over 3 sites: 2 in southern British Columbia, Canada, and 1 off Western Australia. Underwater sound peaked between 70 and 400 Hz, exhibiting strong tones in this frequency range related to engine and propeller rotation. Sound propagation models were applied to compute monopole source levels, with the source assumed 1 m below the sea surface. Broadband source levels (10-48 000 Hz) increased from 134 to 171 dB re 1 μPa @ 1 m with speed from 3 to 16 m/s (10-56 km/h). Source power spectral density percentile levels and 1/3 octave band levels are given for use in predictive modeling of underwater sound of these boats as part of environmental impact assessments.

Non-rigid multi-frame registration of cell nuclei in live cell fluorescence microscopy image data.

PubMed

Tektonidis, Marco; Kim, Il-Han; Chen, Yi-Chun M; Eils, Roland; Spector, David L; Rohr, Karl

2015-01-01

The analysis of the motion of subcellular particles in live cell microscopy images is essential for understanding biological processes within cells. For accurate quantification of the particle motion, compensation of the motion and deformation of the cell nucleus is required. We introduce a non-rigid multi-frame registration approach for live cell fluorescence microscopy image data. Compared to existing approaches using pairwise registration, our approach exploits information from multiple consecutive images simultaneously to improve the registration accuracy. We present three intensity-based variants of the multi-frame registration approach and we investigate two different temporal weighting schemes. The approach has been successfully applied to synthetic and live cell microscopy image sequences, and an experimental comparison with non-rigid pairwise registration has been carried out. Copyright © 2014 Elsevier B.V. All rights reserved.

76 FR 62762 - Certain Large Diameter Carbon and Alloy Seamless Standard, Line and Pressure Pipe From Japan...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-11

... line applications such as oil, gas, or water pipeline, or utility distribution systems. Seamless pressure pipes are intended for the conveyance of water, steam, petrochemicals, chemicals, oil products... Fahrenheit, at various American Society of Mechanical Engineers (``ASME'') code stress levels. Alloy pipes...

77 FR 50465 - Certain Small Diameter Carbon and Alloy Seamless Standard, Line and Pressure Pipe From Romania...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-21

...- 795, and the American Petroleum Institute (API) 5L specifications and meeting the physical parameters... standard, line, or pressure pipe applications and meeting the physical parameters described below.... The scope of this review includes all seamless pipe meeting the physical parameters described above...

Understanding Rigid Geometric Transformations: Jeff's Learning Path for Translation

ERIC Educational Resources Information Center

Yanik, Huseyin Bahadir; Flores, Alfinio

2009-01-01

This article describes the development of knowledge and understanding of translations of Jeff, a prospective elementary teacher, during a teaching experiment that also included other rigid transformations. His initial conceptions of translations and other rigid transformations were characterized as undefined motions of a single object. He…

21 CFR 874.4680 - Bronchoscope (flexible or rigid) and accessories.

Code of Federal Regulations, 2010 CFR

2010-04-01

... (flexible or rigid) and accessories. (a) Identification. A bronchoscope (flexible or rigid) and accessories... bronchoscope and is intended to examine or treat the larynx and tracheobronchial tree. It is typically used...

Nearly Seamless Vacuum-Insulated Boxes

NASA Technical Reports Server (NTRS)

Stepanian, Christopher J.; Ou, Danny; Hu, Xiangjun

2010-01-01

A design concept, and a fabrication process that would implement the design concept, have been proposed for nearly seamless vacuum-insulated boxes that could be the main structural components of a variety of controlled-temperature containers, including common household refrigerators and insulating containers for shipping foods. In a typical case, a vacuum-insulated box would be shaped like a rectangular parallelepiped conventional refrigerator box having five fully closed sides and a hinged door on the sixth side. Although it is possible to construct the five-closed-side portion of the box as an assembly of five unitary vacuum-insulated panels, it is not desirable to do so because the relatively high thermal conductances of the seams between the panels would contribute significant amounts of heat leakage, relative to the leakage through the panels themselves. In contrast, the proposal would make it possible to reduce heat leakage by constructing the five-closed-side portion of the box plus the stationary portion (if any) of the sixth side as a single, seamless unit; the only remaining seam would be the edge seal around the door. The basic cross-sectional configuration of each side of a vacuum-insulated box according to the proposal would be that of a conventional vacuum-insulated panel: a low-density, porous core material filling a partially evacuated space between face sheets. However, neither the face sheets nor the core would be conventional. The face sheets would be opposite sides of a vacuum bag. The core material would be a flexible polymer-modified silica aerogel of the type described in Silica/Polymer and Silica/Polymer/Fiber Composite Aero - gels (MSC-23736) in this issue of NASA Tech Briefs. As noted in that article, the stiffness of this core material against compression is greater than that of prior aerogels. This is an important advantage because it translates to greater retention of thickness and, hence, of insulation performance when pressure is

Thin structured rigid body for acoustic absorption

NASA Astrophysics Data System (ADS)

Starkey, T. A.; Smith, J. D.; Hibbins, A. P.; Sambles, J. R.; Rance, H. J.

2017-01-01

We present a thin acoustic metamaterial absorber, comprised of only rigid metal and air, that gives rise to near unity absorption of airborne sound on resonance. This simple, easily fabricated, robust structure comprising a perforated metal plate separated from a rigid wall by a deeply subwavelength channel of air is an ideal candidate for a sound absorbing panel. The strong absorption in the system is attributed to the thermo-viscous losses arising from a sound wave guided between the plate and the wall, defining the subwavelength channel.

A new seamless, smooth, interior, absorptive finishing system

NASA Astrophysics Data System (ADS)

D'Antonio, Peter

2003-10-01

Government architecture typically employs classic forms of vaults, domes and other focusing or reflective shapes, usually created with hard materials like concrete and plaster. The use of conventional porous absorption is typically rejected as an acoustical surface material for aesthetic reasons. Hence, many of these new and existing facilities have compromised speech intelligibility and music quality. Acousticians have sought a field-applied, absorptive finishing system that resembles a smooth plaster or painted drywall surface, since the dawn of architectural acoustics. Some success has been achieved using sprayed cellulose or cementitious materials, but surface smoothness has been a challenge. A new approach utilizing a thin microporous layer of mineral particles applied over a mineral wool panel will be described. This material can be applied to almost any shape surface, internally pigmented to match almost any color and renovated. Because of these unique characteristics the new seamless, absorptive, finishing system is being specified for many new and renovated spaces. Application examples will be presented.

Associative memory through rigid origami

NASA Astrophysics Data System (ADS)

Murugan, Arvind; Brenner, Michael

2015-03-01

Mechanisms such as Miura Ori have proven useful in diverse contexts since they have only one degree of freedom that is easily controlled. We combine the theory of rigid origami and associative memory in frustrated neural networks to create structures that can ``learn'' multiple generic folding mechanisms and yet can be robustly controlled. We show that such rigid origami structures can ``recall'' a specific learned mechanism when induced by a physical impulse that only need resemble the desired mechanism (i.e. robust recall through association). Such associative memory in matter, seen before in self-assembly, arises due to a balance between local promiscuity (i.e., many local degrees of freedom) and global frustration which minimizes interference between different learned behaviors. Origami with associative memory can lead to a new class of deployable structures and kinetic architectures with multiple context-dependent behaviors.

Rigid external maxillary distraction and rhinoplasty for pyknodysostosis.

PubMed

Varol, Altan; Sabuncuoglu, Fidan Alakus; Sencimen, Metin; Akcam, Timur; Olmez, Hüseyin; Basa, Selçuk

2011-05-01

This article reports the treatment of an 33-year-old female patient with pyknodysostosis by rigid external distraction II midface distraction system. The patient with pyknodysostosis described in this report had severe midfacial hypoplasia. Correction of this by use of routine orthognathic surgery would require osteosynthesis and bone grafting. Risk of infection and/or nonunion after such a surgical procedure was considered too great, and therefore the possibility of treatment by distraction osteogenesis of the maxilla was evaluated. The rigid external distraction II midface distraction system was used to relocate the hypoplastic maxilla at anterior-inferior projection. Distraction osteogenesis should be considered as the primary reconstructive method for maxillofacial deformities in patients with sclerosing bone dysplasias, since this is the second reported case treated successfully with rigid external distraction.

A universal phage display system for the seamless construction of Fab libraries.

PubMed

Nelson, Renae S; Valadon, Philippe

2017-11-01

The construction of Fab phage libraries requires the cloning of domains from both the light and the heavy chain of antibodies. Despite the advent of powerful strategies such as splicing-by-overlap extension PCR, obtaining high quality libraries with excellent coverage remains challenging. Here, we explored the use of type IIS restriction enzymes for the seamless cloning of Fab libraries. We analyzed human, murine and rabbit germline antibody repertoires and identified combinations of restriction enzymes that exhibit very few or no recognition sites in the antibody sequences. We describe three phagemid vectors, pUP-22Hb, pUP-22Mc and pUP-22Rc, which were employed for cloning the Fab repertoire of these hosts using BsmBI and SapI (human) or SapI alone (mouse and rabbit). Using human serum albumin as a model immunization, we built a mouse/human chimeric Fab library and a mouse Fab library in a single step ligation and successfully panned multiple cognate antibodies. The overall process is highly scalable and faster than PCR-based techniques, with a Fab insertion success rate of around 80%. By using carefully chosen overhangs on each end of the antibody domains, this approach paves the way to the universal, sequence- and vector-independent cloning and reformatting of antibody libraries. Copyright © 2017 Elsevier B.V. All rights reserved.

Pink frilly dresses and the avoidance of all things "girly": children's appearance rigidity and cognitive theories of gender development.

PubMed

Halim, May Ling; Ruble, Diane N; Tamis-LeMonda, Catherine S; Zosuls, Kristina M; Lurye, Leah E; Greulich, Faith K

2014-04-01

Many young children pass through a stage of gender appearance rigidity; girls insist on wearing dresses, often pink and frilly, whereas boys refuse to wear anything with a hint of femininity. In 2 studies, we investigated the prevalence of this apparent hallmark of early gender development and its relation to children's growing identification with a gender category. Study 1a examined the prevalence of this behavior and whether it would exhibit a developmental pattern of rigidity followed by flexibility, consistent with past research on identity-related cognitions. Interviews with 76 White, middle-class parents and their 3- to 6-year-old children revealed that about two thirds of parents of 3- and 4-year-old girls and almost half (44%) of parents of 5- and 6-year-old boys reported that their children had exhibited a period of rigidity in their gender-related appearance behavior. Appearance rigidity was not related to parents' preferences for their children's gender-typed clothing. Study 1b examined whether cognitive theories of identity development could shed light on gender appearance rigidity. The more important and positive children considered their gender and the more children understood that gender categories remain stable over time (gender stability), the more likely children were to wear gender-typed outfits. In Study 2, we extended this research to a more diverse population and found that gender appearance rigidity was also prevalent in 267 4-year-old children in the United States from African American, Chinese, Dominican, and Mexican immigrant low-income backgrounds. Results suggest that rigid gender-related appearance behavior can be seen among young children from different backgrounds and might reflect early developing cognitions about gender identity. PsycINFO Database Record (c) 2014 APA, all rights reserved.

Discriminating Rigid from Nonrigid Motion

DTIC Science & Technology

1989-07-31

motion can be given a three-dimensional interpretation using a constraint of rigidity. Kruppa’s result and others (Faugeras & Maybank , 1989; Huang...Experimental Psychology: Human Perception and Performance, 10, 1-11. Faugeras, 0., & Maybank , S. (1989). Motion from point matches: multiplicity of

Elasticity of Relativistic Rigid Bodies?

NASA Astrophysics Data System (ADS)

Smarandache, Florentin

2013-10-01

In the classical Twin Paradox, according to the Special Theory of Relativity, when the traveling twin blasts off from the Earth to a relative velocity v =√{/3 } 2 c with respect to the Earth, his measuring stick and other physical objects in the direction of relative motion shrink to half their lengths. How is that possible in the real physical world to have let's say a rigid rocket shrinking to half and then later elongated back to normal as an elastic material when it stops? What is the explanation for the traveler's measuring stick and other physical objects, in effect, return to the same length to their original length in the Stay-At-Home, but there is no record of their having shrunk? If it's a rigid (not elastic) object, how can it shrink and then elongate back to normal? It might get broken in such situation.

78 FR 77651 - Seamless Refined Copper Pipe and Tube From Mexico: Preliminary Results of Antidumping Duty...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-24

... two producers/ exporters of the subject merchandise, GD Affiliates S. de R.L. de C.V. (Golden Dragon... Trading Co. Ltd.; 3) Golden Dragon Holding (Hong Kong) International, Ltd.; 4) GD Copper U.S.A. Inc.; 5... collectively referred to as Golden Dragon. See, e.g., Seamless Refined Copper Pipe and Tube From Mexico: Final...

Hydrodynamics of a flexible plate between pitching rigid plates

NASA Astrophysics Data System (ADS)

Kim, Junyoung; Kim, Daegyoum

2017-11-01

The dynamics of a flexible plate have been studied as a model problem in swimming and flying of animals and fluid-structure interaction of plants and flags. Motivated by fish schooling and an array of sea grasses, we investigate the dynamics of a flexible plate closely placed between two pitching rigid plates. In most studies on passive deformation of the flexible plate, the plate is immersed in a uniform flow or a wavy flow. However, in this study, the flexible plate experiences periodic deformation by the oscillatory flow generated by the prescribed pitching motion of the rigid plates. In our model, the pitching axes of the rigid plates and the clamping position of the flexible plate are aligned on the same line. The flexible plate shows various responses depending on length and pitching frequency of rigid plates, thickness of a flexible plate, and free-stream velocity. To find the effect of each variable on the response of the flexible plate, amplitude of a trailing edge and modal contribution of a flapping motion are compared, and flow structure around the flexible plate is examined.

Seamless data-range change using punctured convolutional codes for time-varying signal-to-noise ratios

NASA Technical Reports Server (NTRS)

Feria, Y.; Cheung, K.-M.

1995-01-01

In a time-varying signal-to-noise ration (SNR) environment, symbol rate is often changed to maximize data return. However, the symbol-rate change has some undesirable effects, such as changing the transmission bandwidth and perhaps causing the receiver symbol loop to lose lock temporarily, thus losing some data. In this article, we are proposing an alternate way of varying the data rate without changing the symbol rate and, therefore, the transmission bandwidth. The data rate change is achieved in a seamless fashion by puncturing the convolutionally encoded symbol stream to adapt to the changing SNR environment. We have also derived an exact expression to enumerate the number of distinct puncturing patterns. To demonstrate this seamless rate change capability, we searched for good puncturing patterns for the Galileo (14,1/4) convolutional code and changed the data rates by using the punctured codes to match the Galileo SNR profile of November 9, 1997. We show that this scheme reduces the symbol-rate changes from nine to two and provides a comparable data return in a day and a higher symbol SNR during most of the day.

A General Method for the Chemical Synthesis of Large-Scale, Seamless Transition Metal Dichalcogenide Electronics.

PubMed

Li, Li; Guo, Yichuan; Sun, Yuping; Yang, Long; Qin, Liang; Guan, Shouliang; Wang, Jinfen; Qiu, Xiaohui; Li, Hongbian; Shang, Yuanyuan; Fang, Ying

2018-03-01

The capability to directly build atomically thin transition metal dichalcogenide (TMD) devices by chemical synthesis offers important opportunities to achieve large-scale electronics and optoelectronics with seamless interfaces. Here, a general approach for the chemical synthesis of a variety of TMD (e.g., MoS 2 , WS 2 , and MoSe 2 ) device arrays over large areas is reported. During chemical vapor deposition, semiconducting TMD channels and metallic TMD/carbon nanotube (CNT) hybrid electrodes are simultaneously formed on CNT-patterned substrate, and then coalesce into seamless devices. Chemically synthesized TMD devices exhibit attractive electrical and mechanical properties. It is demonstrated that chemically synthesized MoS 2 -MoS 2 /CNT devices have Ohmic contacts between MoS 2 /CNT hybrid electrodes and MoS 2 channels. In addition, MoS 2 -MoS 2 /CNT devices show greatly enhanced mechanical stability and photoresponsivity compared with conventional gold-contacted devices, which makes them suitable for flexible optoelectronics. Accordingly, a highly flexible pixel array based on chemically synthesized MoS 2 -MoS 2 /CNT photodetectors is applied for image sensing. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Seamless Data-Rate Change Using Punctured Convolutional Codes for Time-Varying Signal-to-Noise Ratios

NASA Astrophysics Data System (ADS)

Feria, Y.; Cheung, K.-M.

1994-10-01

In a time-varying signal-to-noise ratio (SNR) environment, symbol rate is often changed to maximize data return. However, the symbol-rate change has some undesirable effects, such as changing the transmission bandwidth and perhaps causing the receiver symbol loop to lose lock temporarily, thus losing some data. In this article, we are proposing an alternate way of varying the data rate without changing the symbol rate and, therefore, the transmission bandwidth. The data rate change is achieved in a seamless fashion by puncturing the convolutionally encoded symbol stream to adapt to the changing SNR environment. We have also derived an exact expression to enumerate the number of distinct puncturing patterns. To demonstrate this seamless rate-change capability, we searched for good puncturing patterns for the Galileo (14,1/4) convolutional code and changed the data rates by using the punctured codes to match the Galileo SNR profile of November 9, 1997. We show that this scheme reduces the symbol-rate changes from nine to two and provides a comparable data return in a day and a higher symbol SNR during most of the day.

Seamless data-range change using punctured convolutional codes for time-varying signal-to-noise ratios

NASA Astrophysics Data System (ADS)

Feria, Y.; Cheung, K.-M.

1995-02-01

In a time-varying signal-to-noise ration (SNR) environment, symbol rate is often changed to maximize data return. However, the symbol-rate change has some undesirable effects, such as changing the transmission bandwidth and perhaps causing the receiver symbol loop to lose lock temporarily, thus losing some data. In this article, we are proposing an alternate way of varying the data rate without changing the symbol rate and, therefore, the transmission bandwidth. The data rate change is achieved in a seamless fashion by puncturing the convolutionally encoded symbol stream to adapt to the changing SNR environment. We have also derived an exact expression to enumerate the number of distinct puncturing patterns. To demonstrate this seamless rate change capability, we searched for good puncturing patterns for the Galileo (14,1/4) convolutional code and changed the data rates by using the punctured codes to match the Galileo SNR profile of November 9, 1997. We show that this scheme reduces the symbol-rate changes from nine to two and provides a comparable data return in a day and a higher symbol SNR during most of the day.

NONUNIFORM FOURIER TRANSFORMS FOR RIGID-BODY AND MULTI-DIMENSIONAL ROTATIONAL CORRELATIONS

PubMed Central

BAJAJ, CHANDRAJIT; BAUER, BENEDIKT; BETTADAPURA, RADHAKRISHNA; VOLLRATH, ANTJE

2013-01-01

The task of evaluating correlations is central to computational structural biology. The rigid-body correlation problem seeks the rigid-body transformation (R, t), R ∈ SO(3), t ∈ ℝ3 that maximizes the correlation between a pair of input scalar-valued functions representing molecular structures. Exhaustive solutions to the rigid-body correlation problem take advantage of the fast Fourier transform to achieve a speedup either with respect to the sought translation or rotation. We present PFcorr, a new exhaustive solution, based on the non-equispaced SO(3) Fourier transform, to the rigid-body correlation problem; unlike previous solutions, ours achieves a combination of translational and rotational speedups without requiring equispaced grids. PFcorr can be straightforwardly applied to a variety of problems in protein structure prediction and refinement that involve correlations under rigid-body motions of the protein. Additionally, we show how it applies, along with an appropriate flexibility model, to analogs of the above problems in which the flexibility of the protein is relevant. PMID:24379643

Correlation of impression removal force with elastomeric impression material rigidity and hardness.

PubMed

Walker, Mary P; Alderman, Nick; Petrie, Cynthia S; Melander, Jennifer; McGuire, Jacob

2013-07-01

Difficult impression removal has been linked to high rigidity and hardness of elastomeric impression materials. In response to this concern, manufacturers have reformulated their materials to reduce rigidity and hardness to decrease removal difficulty; however, the relationship between impression removal and rigidity or hardness has not been evaluated. The purpose of this study was to determine if there is a positive correlation between impression removal difficulty and rigidity or hardness of current elastomeric impression materials. Light- and medium-body polyether (PE), vinylpolysiloxane (VPS), and hybrid vinyl polyether siloxane (VPES) impression materials were tested (n = 5 for each material/consistency/test method). Rigidity (elastic modulus) was measured via tensile testing of dumbbell-shaped specimens (Die C, ASTM D412). Shore A hardness was measured using disc specimens according to ASTM D2240-05 test specifications. Impressions were also made of a custom stainless steel model using a custom metal tray that could be attached to a universal tester to measure associated removal force. Within each impression material consistency, one-factor ANOVA and Tukey's post hoc analyses (α = 0.05) were used to compare rigidity, hardness, and removal force of the three types of impression materials. A Pearson's correlation (α = 0.05) was used to evaluate the association between impression removal force and rigidity or hardness. With medium-body materials, VPS exhibited significantly higher (p ≤ 0.05) rigidity and hardness than VPES or PE, while PE impressions required significantly higher (p ≤ 0.05) removal force than VPS or VPES impressions. With light-body materials, VPS again demonstrated significantly higher (p ≤ 0.05) hardness than VPES or PE, while the rigidity of the light-body materials did not significantly differ between materials (p > 0.05); however, just as with the medium-body materials, light-body PE impressions required significantly higher (p �

77 FR 25136 - Seamless Refined Copper Pipe and Tube From Mexico: Preliminary Results of Antidumping Duty New...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-27

..., expanded end, crimped end, threaded), coating (e.g., plastic, paint), insulation, attachments (e.g., plain... ``line sets'' of seamless refined copper tubes (with or without fittings or insulation) suitable for connecting an outdoor air conditioner or heat pump to an indoor evaporator unit. The phrase ``all sets of...

Rigidity of the magic pentagram game

NASA Astrophysics Data System (ADS)

Kalev, Amir; Miller, Carl A.

2018-01-01

A game is rigid if a near-optimal score guarantees, under the sole assumption of the validity of quantum mechanics, that the players are using an approximately unique quantum strategy. Rigidity has a vital role in quantum cryptography as it permits a strictly classical user to trust behavior in the quantum realm. This property can be traced back as far as 1998 (Mayers and Yao) and has been proved for multiple classes of games. In this paper we prove ridigity for the magic pentagram game, a simple binary constraint satisfaction game involving two players, five clauses and ten variables. We show that all near-optimal strategies for the pentagram game are approximately equivalent to a unique strategy involving real Pauli measurements on three maximally-entangled qubit pairs.

Rigidity of the magic pentagram game.

PubMed

Kalev, Amir; Miller, Carl A

2018-01-01

A game is rigid if a near-optimal score guarantees, under the sole assumption of the validity of quantum mechanics, that the players are using an approximately unique quantum strategy. Rigidity has a vital role in quantum cryptography as it permits a strictly classical user to trust behavior in the quantum realm. This property can be traced back as far as 1998 (Mayers and Yao) and has been proved for multiple classes of games. In this paper we prove ridigity for the magic pentagram game, a simple binary constraint satisfaction game involving two players, five clauses and ten variables. We show that all near-optimal strategies for the pentagram game are approximately equivalent to a unique strategy involving real Pauli measurements on three maximally-entangled qubit pairs.

Elastic properties of rigid fiber-reinforced composites

NASA Astrophysics Data System (ADS)

Chen, J.; Thorpe, M. F.; Davis, L. C.

1995-05-01

We study the elastic properties of rigid fiber-reinforced composites with perfect bonding between fibers and matrix, and also with sliding boundary conditions. In the dilute region, there exists an exact analytical solution. Around the rigidity threshold we find the elastic moduli and Poisson's ratio by decomposing the deformation into a compression mode and a rotation mode. For perfect bonding, both modes are important, whereas only the compression mode is operative for sliding boundary conditions. We employ the digital-image-based method and a finite element analysis to perform computer simulations which confirm our analytical predictions.

Non-rigid alignment in electron tomography in materials science.

PubMed

Printemps, Tony; Bernier, Nicolas; Bleuet, Pierre; Mula, Guido; Hervé, Lionel

2016-09-01

Electron tomography is a key technique that enables the visualization of an object in three dimensions with a resolution of about a nanometre. High-quality 3D reconstruction is possible thanks to the latest compressed sensing algorithms and/or better alignment and preprocessing of the 2D projections. Rigid alignment of 2D projections is routine in electron tomography. However, it cannot correct misalignments induced by (i) deformations of the sample due to radiation damage or (ii) drifting of the sample during the acquisition of an image in scanning transmission electron microscope mode. In both cases, those misalignments can give rise to artefacts in the reconstruction. We propose a simple-to-implement non-rigid alignment technique to correct those artefacts. This technique is particularly suited for needle-shaped samples in materials science. It is initiated by a rigid alignment of the projections and it is then followed by several rigid alignments of different parts of the projections. Piecewise linear deformations are applied to each projection to force them to simultaneously satisfy the rigid alignments of the different parts. The efficiency of this technique is demonstrated on three samples, an intermetallic sample with deformation misalignments due to a high electron dose typical to spectroscopic electron tomography, a porous silicon sample with an extremely thin end particularly sensitive to electron beam and another porous silicon sample that was drifting during image acquisitions. © 2016 The Authors Journal of Microscopy © 2016 Royal Microscopical Society.

Enhanced rigid-bond restraints

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thorn, Andrea; Dittrich, Birger; Sheldrick, George M., E-mail: gsheldr@shelx.uni-ac.gwdg.de

2012-07-01

An extension is proposed to the rigid-bond description of atomic thermal motion in crystals. The rigid-bond model [Hirshfeld (1976 ▶). Acta Cryst. A32, 239–244] states that the mean-square displacements of two atoms are equal in the direction of the bond joining them. This criterion is widely used for verification (as intended by Hirshfeld) and also as a restraint in structure refinement as suggested by Rollett [Crystallographic Computing (1970 ▶), edited by F. R. Ahmed et al., pp. 167–181. Copenhagen: Munksgaard]. By reformulating this condition, so that the relative motion of the two atoms is required to be perpendicular to themore » bond, the number of restraints that can be applied per anisotropic atom is increased from about one to about three. Application of this condition to 1,3-distances in addition to the 1,2-distances means that on average just over six restraints can be applied to the six anisotropic displacement parameters of each atom. This concept is tested against very high resolution data of a small peptide and employed as a restraint for protein refinement at more modest resolution (e.g. 1.7 Å)« less

Design requirements for rigid printed wiring boards and assemblies. NASA Handbook

NASA Technical Reports Server (NTRS)

1986-01-01

The NASA requirements for assuring reliable rigid printed wiring board design are prescribed. Basic considerations necessary to assure reliable rigid printed wiring board design are described and incorporated.

[Subacute worsening of rigidity in a patient with Parkinson disease].

PubMed

Bekkelund, Svein Ivar; Lilleng, Hallvard; Arntzen, Kjell Arne

2008-09-25

In this paper we report a patient with Parkinson's disease (PD) presenting with subacute motor symptoms, especially rigidity. The 75-year-old man had relatively moderate PD for 12 years, which was treated with levodopa until he developed marked rigidity. The rigidity became worse, with prolonged off-periods, despite treatment with increased doses of levodopa. At the time of hospitalization he was unable to walk independently, but the clinical neurological examination only revealed aggravation of parkinsonian signs. MRI of the brain showed an intracerebral lesion, which was later confirmed as glioblastoma multiforme. The main feature was onset of marked rigidity a few weeks before severe tumour-specific symptoms developed, but spasticity or hyperreflexia were neither reported at the time of symptom exacerbation nor during hospitalization. This case demonstrates the importance of considering other underlying neurological disease in parkinsonian patients presenting with rapid progression of parkinsonian symptoms.

RF-photonic chirp encoder and compressor for seamless analysis of information flow.

PubMed

Zalevsky, Zeev; Shemer, Amir; Zach, Shlomo

2008-05-26

In this paper we realize an RF photonic chirp compression system that compresses a continuous stream of incoming RF data (modulated on top of an optical carrier) into a train of temporal short pulses. Each pulse in the train can be separated and treated individually while being sampled by low rate optical switch and without temporal loses of the incoming flow of information. Each such pulse can be filtered and analyzed differently. The main advantage of the proposed system is its capability of being able to handle, seamlessly, high rate information flow with all-optical means and with low rate optical switches.

21 CFR 874.4760 - Nasopharyngoscope (flexible or rigid) and accessories.

Code of Federal Regulations, 2010 CFR

2010-04-01

... made of materials such as stainless steel and flexible plastic. This generic type of device includes..., salpingoscope, flexible foreign body claw, flexible biopsy forceps, rigid biopsy curette, flexible biospy brush, rigid biopsy forceps and flexible biopsy curette, but excludes the fiberoptic light source and carrier...

21 CFR 874.4760 - Nasopharyngoscope (flexible or rigid) and accessories.

Code of Federal Regulations, 2011 CFR

2011-04-01

... made of materials such as stainless steel and flexible plastic. This generic type of device includes..., salpingoscope, flexible foreign body claw, flexible biopsy forceps, rigid biopsy curette, flexible biospy brush, rigid biopsy forceps and flexible biopsy curette, but excludes the fiberoptic light source and carrier...

A seamless acquisition digital storage oscilloscope with three-dimensional waveform display

NASA Astrophysics Data System (ADS)

Yang, Kuojun; Tian, Shulin; Zeng, Hao; Qiu, Lei; Guo, Lianping

2014-04-01

In traditional digital storage oscilloscope (DSO), sampled data need to be processed after each acquisition. During data processing, the acquisition is stopped and oscilloscope is blind to the input signal. Thus, this duration is called dead time. With the rapid development of modern electronic systems, the effect of infrequent events becomes significant. To capture these occasional events in shorter time, dead time in traditional DSO that causes the loss of measured signal needs to be reduced or even eliminated. In this paper, a seamless acquisition oscilloscope without dead time is proposed. In this oscilloscope, three-dimensional waveform mapping (TWM) technique, which converts sampled data to displayed waveform, is proposed. With this technique, not only the process speed is improved, but also the probability information of waveform is displayed with different brightness. Thus, a three-dimensional waveform is shown to the user. To reduce processing time further, parallel TWM which processes several sampled points simultaneously, and dual-port random access memory based pipelining technique which can process one sampling point in one clock period are proposed. Furthermore, two DDR3 (Double-Data-Rate Three Synchronous Dynamic Random Access Memory) are used for storing sampled data alternately, thus the acquisition can continue during data processing. Therefore, the dead time of DSO is eliminated. In addition, a double-pulse test method is adopted to test the waveform capturing rate (WCR) of the oscilloscope and a combined pulse test method is employed to evaluate the oscilloscope's capture ability comprehensively. The experiment results show that the WCR of the designed oscilloscope is 6 250 000 wfms/s (waveforms per second), the highest value in all existing oscilloscopes. The testing results also prove that there is no dead time in our oscilloscope, thus realizing the seamless acquisition.

A seamless acquisition digital storage oscilloscope with three-dimensional waveform display

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yang, Kuojun, E-mail: kuojunyang@gmail.com; Guo, Lianping; School of Electrical and Electronic Engineering, Nanyang Technological University

In traditional digital storage oscilloscope (DSO), sampled data need to be processed after each acquisition. During data processing, the acquisition is stopped and oscilloscope is blind to the input signal. Thus, this duration is called dead time. With the rapid development of modern electronic systems, the effect of infrequent events becomes significant. To capture these occasional events in shorter time, dead time in traditional DSO that causes the loss of measured signal needs to be reduced or even eliminated. In this paper, a seamless acquisition oscilloscope without dead time is proposed. In this oscilloscope, three-dimensional waveform mapping (TWM) technique, whichmore » converts sampled data to displayed waveform, is proposed. With this technique, not only the process speed is improved, but also the probability information of waveform is displayed with different brightness. Thus, a three-dimensional waveform is shown to the user. To reduce processing time further, parallel TWM which processes several sampled points simultaneously, and dual-port random access memory based pipelining technique which can process one sampling point in one clock period are proposed. Furthermore, two DDR3 (Double-Data-Rate Three Synchronous Dynamic Random Access Memory) are used for storing sampled data alternately, thus the acquisition can continue during data processing. Therefore, the dead time of DSO is eliminated. In addition, a double-pulse test method is adopted to test the waveform capturing rate (WCR) of the oscilloscope and a combined pulse test method is employed to evaluate the oscilloscope's capture ability comprehensively. The experiment results show that the WCR of the designed oscilloscope is 6 250 000 wfms/s (waveforms per second), the highest value in all existing oscilloscopes. The testing results also prove that there is no dead time in our oscilloscope, thus realizing the seamless acquisition.« less

Operative rigid bronchoscopy: indications, basic techniques and results.

PubMed

Petrella, Francesco; Borri, Alessandro; Casiraghi, Monica; Cavaliere, Sergio; Donghi, Stefano; Galetta, Domenico; Gasparri, Roberto; Guarize, Juliana; Pardolesi, Alessandro; Solli, Piergiorgio; Tessitore, Adele; Venturino, Marco; Veronesi, Giulia; Spaggiari, Lorenzo

2014-05-27

Palliative airway treatments are essential to improve quality and length of life in lung cancer patients with central airway obstruction. Rigid bronchoscopy has proved to be an excellent tool to provide airway access and control in this cohort of patients. The main indication for rigid bronchoscopy in adult bronchology remains central airway obstruction due to neoplastic or non-neoplastic disease. We routinely use negative pressure ventilation (NPV) under general anaesthesia to prevent intraoperative apnoea and respiratory acidosis. This procedure allows opioid sparing, a shorter recovery time and avoids manually assisted ventilation, thereby reducing the amount of oxygen needed, while maintaining optimal surgical conditions. The major indication for NPV rigid bronchoscopy at our institution has been airway obstruction by neoplastic tracheobronchial tissue, mainly treated by laser-assisted mechanical dissection. When strictly necessary, we use silicone stents for neoplastic or cicatricial strictures, reserving metal stents to cover tracheo-oesophageal fistulae. NPV rigid bronchoscopy is an excellent tool for the endoscopic treatment of locally advanced tumours of the lung, especially when patients have exhausted the conventional therapeutic resources. Laser-assisted mechanical resection and stent placement are the most effective procedures for preserving quality of life in patients with advanced stage cancer. © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-thoracic Surgery. All rights reserved.

Accuracy limit of rigid 3-point water models

NASA Astrophysics Data System (ADS)

Izadi, Saeed; Onufriev, Alexey V.

2016-08-01

Classical 3-point rigid water models are most widely used due to their computational efficiency. Recently, we introduced a new approach to constructing classical rigid water models [S. Izadi et al., J. Phys. Chem. Lett. 5, 3863 (2014)], which permits a virtually exhaustive search for globally optimal model parameters in the sub-space that is most relevant to the electrostatic properties of the water molecule in liquid phase. Here we apply the approach to develop a 3-point Optimal Point Charge (OPC3) water model. OPC3 is significantly more accurate than the commonly used water models of same class (TIP3P and SPCE) in reproducing a comprehensive set of liquid bulk properties, over a wide range of temperatures. Beyond bulk properties, we show that OPC3 predicts the intrinsic charge hydration asymmetry (CHA) of water — a characteristic dependence of hydration free energy on the sign of the solute charge — in very close agreement with experiment. Two other recent 3-point rigid water models, TIP3PFB and H2ODC, each developed by its own, completely different optimization method, approach the global accuracy optimum represented by OPC3 in both the parameter space and accuracy of bulk properties. Thus, we argue that an accuracy limit of practical 3-point rigid non-polarizable models has effectively been reached; remaining accuracy issues are discussed.

Diffusion coefficient and shear viscosity of rigid water models.

PubMed

Tazi, Sami; Boţan, Alexandru; Salanne, Mathieu; Marry, Virginie; Turq, Pierre; Rotenberg, Benjamin

2012-07-18

We report the diffusion coefficient and viscosity of popular rigid water models: two non-polarizable ones (SPC/E with three sites, and TIP4P/2005 with four sites) and a polarizable one (Dang-Chang, four sites). We exploit the dependence of the diffusion coefficient on the system size (Yeh and Hummer 2004 J. Phys. Chem. B 108 15873) to obtain the size-independent value. This also provides an estimate of the viscosity of all water models, which we compare to the Green-Kubo result. In all cases, a good agreement is found. The TIP4P/2005 model is in better agreement with the experimental data for both diffusion and viscosity. The SPC/E and Dang-Chang models overestimate the diffusion coefficient and underestimate the viscosity.

77 FR 13079 - Certain Large Diameter Carbon and Alloy Seamless Standard, Line, and Pressure Pipe (Over 41/2

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-05

... such as oil, gas, or water pipeline, or utility distribution systems. Seamless pressure pipes are intended for the conveyance of water, steam, petrochemicals, chemicals, oil products, natural gas and other... high temperature service. They are intended for the low temperature and pressure conveyance of water...

Microsphere-Based Seamless Scaffolds Containing Macroscopic Gradients of Encapsulated Factors for Tissue Engineering

PubMed Central

Singh, Milind; Morris, Casey P.; Ellis, Ryan J.; Detamore, Michael S.

2008-01-01

Spatial and temporal control of bioactive signals in three-dimensional (3D) tissue engineering scaffolds is greatly desired. Coupled together, these attributes may mimic and maintain complex signal patterns, such as those observed during axonal regeneration or neovascularization. Seamless polymer constructs may provide a route to achieve spatial control of signal distribution. In this study, a novel microparticle-based scaffold fabrication technique is introduced as a method to create 3D scaffolds with spatial control over model dyes using uniform poly(D,L-lactide-co-glycolide) microspheres. Uniform microspheres were produced using the Precision Particle Fabrication technique. Scaffolds were assembled by flowing microsphere suspensions into a cylindrical glass mold, and then microspheres were physically attached to form a continuous scaffold using ethanol treatment. An ethanol soak of 1 h was found to be optimum for improved mechanical characteristics. Morphological and physical characterization of the scaffolds revealed that microsphere matrices were porous (41.1 ± 2.1%) and well connected, and their compressive stiffness ranged from 142 to 306 kPa. Culturing chondrocytes on the scaffolds revealed the compatibility of these substrates with cell attachment and viability. In addition, bilayered, multilayered, and gradient scaffolds were fabricated, exhibiting excellent spatial control and resolution. Such novel scaffolds can serve as sustained delivery devices of heterogeneous signals in a continuous and seamless manner, and may be particularly useful in future interfacial tissue engineering investigations. PMID:18795865

Non-Rigid Structure Estimation in Trajectory Space from Monocular Vision

PubMed Central

Wang, Yaming; Tong, Lingling; Jiang, Mingfeng; Zheng, Junbao

2015-01-01

In this paper, the problem of non-rigid structure estimation in trajectory space from monocular vision is investigated. Similar to the Point Trajectory Approach (PTA), based on characteristic points’ trajectories described by a predefined Discrete Cosine Transform (DCT) basis, the structure matrix was also calculated by using a factorization method. To further optimize the non-rigid structure estimation from monocular vision, the rank minimization problem about structure matrix is proposed to implement the non-rigid structure estimation by introducing the basic low-rank condition. Moreover, the Accelerated Proximal Gradient (APG) algorithm is proposed to solve the rank minimization problem, and the initial structure matrix calculated by the PTA method is optimized. The APG algorithm can converge to efficient solutions quickly and lessen the reconstruction error obviously. The reconstruction results of real image sequences indicate that the proposed approach runs reliably, and effectively improves the accuracy of non-rigid structure estimation from monocular vision. PMID:26473863

Optimal matrix rigidity for stress fiber polarization in stem cells

PubMed Central

Rehfeldt, F.; Brown, A. E. X.; Discher, D. E.; Safran, S. A.

2010-01-01

The shape and differentiation of human mesenchymal stem cells is especially sensitive to the rigidity of their environment; the physical mechanisms involved are unknown. A theoretical model and experiments demonstrate here that the polarization/alignment of stress-fibers within stem cells is a non-monotonic function of matrix rigidity. We treat the cell as an active elastic inclusion in a surrounding matrix whose polarizability, unlike dead matter, depends on the feedback of cellular forces that develop in response to matrix stresses. The theory correctly predicts the monotonic increase of the cellular forces with the matrix rigidity and the alignment of stress-fibers parallel to the long axis of cells. We show that the anisotropy of this alignment depends non-monotonically on matrix rigidity and demonstrate it experimentally by quantifying the orientational distribution of stress-fibers in stem cells. These findings offer a first physical insight for the dependence of stem cell differentiation on tissue elasticity. PMID:20563235

Verification of the Rigidity of the Coulomb Field in Motion

NASA Astrophysics Data System (ADS)

Blinov, S. V.; Bulyzhenkov, I. É.

2018-06-01

Laplace, analyzing the stability of the Solar System, was the first to calculate that the velocity of the motion of force fields can significantly exceed the velocity of light waves. In electrodynamics, the Coulomb field should rigidly accompany its source for instantaneous force action in distant regions. Such rigid motion was recently inferred from experiments at the Frascati Beam Test Facility with short beams of relativistic electrons. The comments of the authors on their observations are at odds with the comments of theoreticians on retarded potentials, which motivates a detailed study of the positions of both sides. Predictions of measurements, based on the Lienard-Wiechert potentials, are used to propose an unambiguous scheme for testing the rigidity of the Coulomb field. Realization of the proposed experimental scheme could independently refute or support the assertions of the Italian physicists regarding the rigid motion of Coulomb fields and likewise the nondual field approach to macroscopic reality.

Fire and ecotoxicological aspects of polyurethane rigid foam.

PubMed

Wittbecker, F W; Giersig, M

2001-01-01

The main characteristics of fire effluents from polyurethane (PUR) foams are comparable to those from natural materials like wood, cork, or wool. This similarity has been demonstrated by comparative data from analytical and toxicological studies. It is therefore presumed that effluents of these materials present similar hazards to human beings and the environment. In almost all fires, dioxins can be found in the smoke and residues. In fires involving PURs, relevant quantities of halogenated dioxins or furans are not to be expected; this has been confirmed by investigations under controlled laboratory conditions. The insulation properties of rigid PUR foam contribute significantly to environmental protection and the conservation of resources. A number of methods for reusing and recycling PUR rigid foam waste have been developed and realized in practise. The possibilities range from reusing the material itself, generating liquid raw materials, and thermal recycling, even for (H)CFC-containing PUR rigid foams, by cocombustion in suitable plants.

Hexagonal-structured epsilon-NbN. Ultra-incompressibility, high shear rigidity, and a possible hard superconducting material

DOE PAGES

Zou, Y.; Wang, X.; Chen, T.; ...

2015-06-01

Exploring the structural stability and elasticity of hexagonal ε-NbN helps discover correlations among its physical properties for scientific and technological applications. Here, for the first time, we measured the ultra-incompressibility and high shear rigidity of polycrystalline hexagonal ε-NbN using ultrasonic interferometry and in situ X-ray diffraction, complemented with first-principles density-functional theory calculations up to 30 GPa in pressure. Using a finite strain equation of state approach, the elastic bulk and shear moduli, as well as their pressure dependences are derived from the measured velocities and densities, yielding BS0 = 373.3(15) GPa, G0 = 200.5(8) GPa, ∂B S/∂P = 3.81(3) andmore » ∂G/∂P = 1.67(1). The hexagonal ε-NbN possesses a very high bulk modulus, rivaling that of superhard material cBN (B0 = 381.1 GPa). The high shear rigidity is comparable to that for superhard γ-B (G 0 = 227.2 GPa). We found that the crystal structure of transition-metal nitrides and the outmost electrons of the corresponding metals may dominate their pressure dependences in bulk and shear moduli. In addition, the elastic moduli, Vickers hardness, Debye temperature, melting temperature and a possible superconductivity of hexagonal ε-NbN all increase with pressures, suggesting its exceptional suitability for applications under extreme conditions.« less

Hexagonal-structured epsilon-NbN. Ultra-incompressibility, high shear rigidity, and a possible hard superconducting material

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zou, Y.; Wang, X.; Chen, T.

Exploring the structural stability and elasticity of hexagonal ε-NbN helps discover correlations among its physical properties for scientific and technological applications. Here, for the first time, we measured the ultra-incompressibility and high shear rigidity of polycrystalline hexagonal ε-NbN using ultrasonic interferometry and in situ X-ray diffraction, complemented with first-principles density-functional theory calculations up to 30 GPa in pressure. Using a finite strain equation of state approach, the elastic bulk and shear moduli, as well as their pressure dependences are derived from the measured velocities and densities, yielding BS0 = 373.3(15) GPa, G0 = 200.5(8) GPa, ∂B S/∂P = 3.81(3) andmore » ∂G/∂P = 1.67(1). The hexagonal ε-NbN possesses a very high bulk modulus, rivaling that of superhard material cBN (B0 = 381.1 GPa). The high shear rigidity is comparable to that for superhard γ-B (G 0 = 227.2 GPa). We found that the crystal structure of transition-metal nitrides and the outmost electrons of the corresponding metals may dominate their pressure dependences in bulk and shear moduli. In addition, the elastic moduli, Vickers hardness, Debye temperature, melting temperature and a possible superconductivity of hexagonal ε-NbN all increase with pressures, suggesting its exceptional suitability for applications under extreme conditions.« less

Exponential Megapriming PCR (EMP) Cloning—Seamless DNA Insertion into Any Target Plasmid without Sequence Constraints

PubMed Central

Ulrich, Alexander; Andersen, Kasper R.; Schwartz, Thomas U.

2012-01-01

We present a fast, reliable and inexpensive restriction-free cloning method for seamless DNA insertion into any plasmid without sequence limitation. Exponential megapriming PCR (EMP) cloning requires two consecutive PCR steps and can be carried out in one day. We show that EMP cloning has a higher efficiency than restriction-free (RF) cloning, especially for long inserts above 2.5 kb. EMP further enables simultaneous cloning of multiple inserts. PMID:23300917

Exponential megapriming PCR (EMP) cloning--seamless DNA insertion into any target plasmid without sequence constraints.

PubMed

Ulrich, Alexander; Andersen, Kasper R; Schwartz, Thomas U

2012-01-01

We present a fast, reliable and inexpensive restriction-free cloning method for seamless DNA insertion into any plasmid without sequence limitation. Exponential megapriming PCR (EMP) cloning requires two consecutive PCR steps and can be carried out in one day. We show that EMP cloning has a higher efficiency than restriction-free (RF) cloning, especially for long inserts above 2.5 kb. EMP further enables simultaneous cloning of multiple inserts.

78 FR 64475 - Certain Large Diameter Carbon and Alloy Seamless Standard, Line, and Pressure Pipe (Over 41/2

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-29

... line applications such as oil, gas, or water pipeline, or utility distribution systems. Seamless pressure pipes are intended for the conveyance of water, steam, petrochemicals, chemicals, oil products... stress levels. Alloy pipes made to ASTM A-335 standard must be used if temperatures and stress levels...

77 FR 59178 - Seamless Refined Copper Pipe and Tube From Mexico: Final Results of Antidumping Duty New Shipper...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-26

... end, expanded end, crimped end, threaded), coating (e.g., plastic, paint), insulation, attachments (e... products, including ``line sets'' of seamless refined copper tubes (with or without fittings or insulation) suitable for connecting an outdoor air conditioner or heat pump to an indoor evaporator unit. The phrase...

Frontal Tasks and Behavior in Rigid or Tremor-Dominant Parkinson Disease.

PubMed

Moretti, Rita; Milner, Vera; Caruso, Paola; Gazzin, Silvia; Rumiati, Raffaella

2017-08-01

Parkinson disease (PD) is not an unambiguous entity, and there is a general consensus for the statement that an akinetic-rigid dominant type of presentation has a worse prognosis, in the follow-up. The aim of our study was to examine the differences in frontal tasks and behavior, in 2 PD naive groups: the rigid and the tremor-dominant types of presentation, according to motor scores. Our study has showed some important differences in frontal tasks and in behavior, performing more apathy, aggressiveness, and irritability in the rigid type, and more depression and anxiety in the tremor-dominant type. The former group causes the caregiver more distress and has a very rapid disease progression. It can be argued that rigid type PD presentation needs specific dedicated cares and more strong clinical attention.

Method to estimate center of rigidity using vibration recordings

USGS Publications Warehouse

Safak, Erdal; Çelebi, Mehmet

1990-01-01

A method to estimate the center of rigidity of buildings by using vibration recordings is presented. The method is based on the criterion that the coherence of translational motions with the rotational motion is minimum at the center of rigidity. Since the coherence is a function of frequency, a gross but frequency-independent measure of the coherency is defined as the integral of the coherence function over the frequency. The center of rigidity is determined by minimizing this integral. The formulation is given for two-dimensional motions. Two examples are presented for the method; a rectangular building with ambient-vibration recordings, and a triangular building with earthquake-vibration recordings. Although the examples given are for buildings, the method can be applied to any structure with two-dimensional motions.

Unbiased estimation in seamless phase II/III trials with unequal treatment effect variances and hypothesis-driven selection rules.

PubMed

Robertson, David S; Prevost, A Toby; Bowden, Jack

2016-09-30

Seamless phase II/III clinical trials offer an efficient way to select an experimental treatment and perform confirmatory analysis within a single trial. However, combining the data from both stages in the final analysis can induce bias into the estimates of treatment effects. Methods for bias adjustment developed thus far have made restrictive assumptions about the design and selection rules followed. In order to address these shortcomings, we apply recent methodological advances to derive the uniformly minimum variance conditionally unbiased estimator for two-stage seamless phase II/III trials. Our framework allows for the precision of the treatment arm estimates to take arbitrary values, can be utilised for all treatments that are taken forward to phase III and is applicable when the decision to select or drop treatment arms is driven by a multiplicity-adjusted hypothesis testing procedure. © 2016 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd. © 2016 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.

Experimental method for determination of bending and torsional rigidities of advanced composite laminates

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maeda, Takenori

1995-11-01

This paper presents an experimental method for the determination of the bending and torsional rigidities of advanced fiber composite laminates with the aid of laser holographic interferometry. The proposed method consists of a four-point bending test and a resonance test. The bending rigidity ratio (D{sub 12}/D{sub 22}) can be determined from the fringe patterns of the four-point bending test. The bending rigidities (D{sub 11} and D{sub 22}) and the torsional rigidity (D{sub 66}) are calculated from the natural frequencies of cantilever plates of the resonance test. The test specimens are carbon/epoxy cross-ply laminates. The adequacy of the experimental method ismore » confirmed by comparing the measured rigidities with the theoretical values obtained from classical lamination theory (CLT) by using the measured tensile properties. The results show that the present method can be used to evaluate the rigidities of orthotropic laminates with reasonably good accuracy.« less

78 FR 63164 - Certain Small Diameter Carbon and Alloy Seamless Standard, Line and Pressure Pipe From Romania...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-23

... American Society for Testing and Materials (ASTM) A- 53, ASTM A-106, ASTM A-333, ASTM A-334, ASTM A-335, ASTM A-589, ASTM A- 795, and the American Petroleum Institute (API) 5L specifications and meeting the... to the application of external heat. Seamless carbon steel pressure pipe meeting the ASTM A- 106...

A Tale of Two Libraries: How Two Library Media Centers Seamlessly Integrate Curriculum, Information Literacy, and Technology

ERIC Educational Resources Information Center

Gold, Stephanie

2005-01-01

The author discusses how two library media centers seamlessly integrate curriculum, information literacy, and technology. Dale Hodges is a library chairperson, a role that carries clout in the William Floyd School District, where the library is a full-fledged department. Located on Long Island in New York, the district has eight schools, more than…

Effect of Heliox on Respiratory Outcomes during Rigid Bronchoscopy in Term Lambs.

PubMed

Sowder, Justin C; Dahl, Mar Janna; Zuspan, Kaitlin R; Albertine, Kurt H; Null, Donald M; Barneck, Mitchell D; Grimmer, J Fredrik

2018-03-01

Objective To (1) compare physiologic changes during rigid bronchoscopy during spontaneous and mechanical ventilation and (2) evaluate the efficacy of a helium-oxygen (heliox) gas mixture as compared with room air during rigid bronchoscopy. Study Design Crossover animal study evaluating physiologic parameters during rigid bronchoscopy. Outcomes were compared with predicted computational fluid analysis. Setting Simulated ventilation via computational fluid dynamics analysis and term lambs undergoing rigid bronchoscopy. Methods Respiratory and physiologic outcomes were analyzed in a lamb model simulating bronchoscopy during foreign body aspiration to compare heliox with room air. The main outcome measures were blood oxygen saturation, heart rate, blood pressure, partial pressure of oxygen, and partial pressure of carbon dioxide. Computational fluid dynamics analysis was performed with SOLIDWORKS within a rigid pediatric bronchoscope during simulated ventilation comparing heliox with room air. Results For room air, lambs desaturated within 3 minutes during mechanical ventilation versus normal oxygen saturation during spontaneous ventilation ( P = .01). No improvement in respiratory outcomes was seen between heliox and room air during mechanical ventilation. Computational fluid dynamics analysis demonstrates increased turbulence within size 3.5 bronchoscopes when comparing heliox and room air. Meaningful comparisons could not be made due to the intolerance of the lambs to heliox in vivo. Conclusion During mechanical ventilation on room air, lambs desaturate more quickly during rigid bronchoscopy on settings that should be adequate. Heliox does not improve ventilation during rigid bronchoscopy.

Optimal Control of Micro Grid Operation Mode Seamless Switching Based on Radau Allocation Method

NASA Astrophysics Data System (ADS)

Chen, Xiaomin; Wang, Gang

2017-05-01

The seamless switching process of micro grid operation mode directly affects the safety and stability of its operation. According to the switching process from island mode to grid-connected mode of micro grid, we establish a dynamic optimization model based on two grid-connected inverters. We use Radau allocation method to discretize the model, and use Newton iteration method to obtain the optimal solution. Finally, we implement the optimization mode in MATLAB and get the optimal control trajectory of the inverters.

Deformable image registration for adaptive radiotherapy with guaranteed local rigidity constraints.

PubMed

König, Lars; Derksen, Alexander; Papenberg, Nils; Haas, Benjamin

2016-09-20

Deformable image registration (DIR) is a key component in many radiotherapy applications. However, often resulting deformations are not satisfying, since varying deformation properties of different anatomical regions are not considered. To improve the plausibility of DIR in adaptive radiotherapy in the male pelvic area, this work integrates a local rigidity deformation model into a DIR algorithm. A DIR framework is extended by constraints, enforcing locally rigid deformation behavior for arbitrary delineated structures. The approach restricts those structures to rigid deformations, while surrounding tissue is still allowed to deform elastically. The algorithm is tested on ten CT/CBCT male pelvis datasets with active rigidity constraints on bones and prostate and compared to the Varian SmartAdapt deformable registration (VSA) on delineations of bladder, prostate and bones. The approach with no rigid structures (REG0) obtains an average dice similarity coefficient (DSC) of 0.87 ± 0.06 and a Hausdorff-Distance (HD) of 8.74 ± 5.95 mm. The new approach with rigid bones (REG1) yields a DSC of 0.87 ± 0.07, HD 8.91 ± 5.89 mm. Rigid deformation of bones and prostate (REG2) obtains 0.87 ± 0.06, HD 8.73 ± 6.01 mm, while VSA yields a DSC of 0.86 ± 0.07, HD 10.22 ± 6.62 mm. No deformation grid foldings are observed for REG0 and REG1 in 7 of 10 cases; for REG2 in 8 of 10 cases, with no grid foldings in prostate, an average of 0.08 % in bladder (REG2: no foldings) and 0.01 % inside the body contour. VSA exhibits grid foldings in each case, with an average percentage of 1.81 % for prostate, 1.74 % for bladder and 0.12 % for the body contour. While REG1 and REG2 keep bones rigid, elastic bone deformations are observed with REG0 and VSA. An average runtime of 26.2 s was achieved with REG1; 31.1 s with REG2, compared to 10.5 s with REG0 and 10.7 s with VMS. With accuracy in the range of VSA, the new approach with constraints delivers physically more plausible deformations in

Synthesis of an A'B' Precursor to Angelmicin B: Product Diversification in the Suárez Lactol Fragmentation.

PubMed

Li, Jialiang; Todaro, Louis; Mootoo, David R

2011-11-01

We describe a synthetic strategy for the angelimicin family of anthraquinoid natural products that involves converting a central highly oxygenated decalin intermediate to the AB and A'B' subunits. Herein, we report the synthesis of the bicyclic A'B' subunit that complements our earlier route to the tricyclic AB framework. The differentiating tact in the two syntheses focused on controlling the Suárez radical fragmentation of lactol precursors by modulating the substrate's structural rigidity. A more flexible lactol gave the tricyclic AB framework, whereas a more rigid substrate led to the bicyclic A'B' precursor, presumably through divergent pathways from the radical produced in the initial fragmentation step. These results establish a versatile advanced synthetic precursor for the angelimicins, and on a more general note, illustrate strategies for applying the Suárez fragmentation to diverse and complex molecular frameworks.

78 FR 35251 - Seamless Refined Copper Pipe and Tube From the People's Republic of China: Final Results and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-12

... and Tube From the People's Republic of China: Final Results and Partial Revocation of 2010/11... and tube (``copper pipe and tube'') from the People's Republic of China (``PRC''). The period of... published Seamless Refined Copper Pipe and Tube From the People's Republic of China: Preliminary Results of...

Development of GABA-sensitive spasticity and rigidity in rats after transient spinal cord ischemia: a qualitative and quantitative electrophysiological and histopathological study.

PubMed

Kakinohana, O; Hefferan, M P; Nakamura, S; Kakinohana, M; Galik, J; Tomori, Z; Marsala, J; Yaksh, T L; Marsala, M

2006-09-01

Transient spinal cord ischemia may lead to a progressive degeneration of spinal interneurons and subsequently to increased hind limb motor tone. In the present work we sought to characterize the rigidity and spasticity components of this altered motor function by: i) tonic electromyographic activity measured in gastrocnemius muscle before and after ischemia, ii) measurement of muscle resistance during the period of ankle flexion and corresponding changes in electromyographic activity, iii) changes in Hoffmann reflex, and, iv) motor evoked potentials. In addition the effect of intrathecal treatment with baclofen (GABAB receptor agonist; 1 microg), nipecotic acid (GABA uptake inhibitor; 300 microg) and dorsal L2-L5 rhizotomy on spasticity and rigidity was studied. Finally, the changes in spinal choline acetyltransferase (ChAT) and vesicular glutamate transporter 2 and 1 (VGLUT2 and VGLUT1) expression were characterized using immunofluorescence and confocal microscopy. At 3-7 days after ischemia an increase in tonic electromyographic activity with a variable degree of rigidity was seen. In animals with modest rigidity a velocity-dependent increase in muscle resistance and corresponding appearance in electromyographic activity (consistent with the presence of spasticity) was measured during ankle rotation (4-612 degrees /s rotation). Measurement of the H-reflex revealed a significant increase in Hmax/Mmax ratio and a significant loss of rate-dependent inhibition. In the same animals a potent increase in motor evoked potential amplitudes was measured and this change correlated positively with the increased H-reflex responses. Spasticity and rigidity were consistently present for a minimum of 3 months after ischemia. Intrathecal treatment with baclofen (GABA B receptor agonist) and nipecotic acid (GABA uptake inhibitor) provided a significant suppression of spasticity, rigidity, H-reflex or motor evoked potentials. Dorsal L2-L5 rhizotomy significantly decreased muscle

46 CFR 131.860 - Rigid liferafts.

Code of Federal Regulations, 2010 CFR

2010-10-01

..., over each entrance to each raft, in letters and numbers at least 102 millimeters (4 inches) high and in a color contrasting to that of the raft. This number must— (1) Be the number of persons the rigid...

Activity-induced collapse and reexpansion of rigid polymers

NASA Astrophysics Data System (ADS)

Harder, J.; Valeriani, C.; Cacciuto, A.

2014-12-01

We study the elastic properties of a rigid filament in a bath of self-propelled particles. We find that while fully flexible filaments swell monotonically upon increasing the strength of the propelling force, rigid filaments soften for moderate activities, collapse into metastable hairpins for intermediate strengths, and eventually reexpand when the strength of the activity of the surrounding fluid is large. This collapse and reexpansion of the filament with the bath activity is reminiscent of the behavior observed in polyelectrolytes in the presence of different concentrations of multivalent salt.

Coherent states for the quantum complete rigid rotor

NASA Astrophysics Data System (ADS)

Fontanari, Daniele; Sadovskií, Dmitrií A.

2018-07-01

Motivated by the possibility to describe orientations of quantum triaxial rigid rotors, such as molecules, with respect to both internal (body-fixed) and external (laboratory) frames, we go through the theory of coherent states and design the appropriate family of coherent states on T∗ SO(3) , the classical phase space of the freely rotating rigid body (the Euler top). We pay particular attention to the resolution of identity property in order to establish the explicit relation between the parameters of the coherent states and classical phase-space variables, actions and angles.

A DNA Origami Mechanical Device for the Regulation of Microcosmic Structural Rigidity.

PubMed

Wan, Neng; Hong, Zhouping; Wang, Huading; Fu, Xin; Zhang, Ziyue; Li, Chao; Xia, Han; Fang, Yan; Li, Maoteng; Zhan, Yi; Yang, Xiangliang

2017-11-01

DNA origami makes it feasible to fabricate a tremendous number of DNA nanostructures with various geometries, dimensions, and functionalities. Moreover, an increasing amount of research on DNA nanostructures is focused on biological and biomedical applications. Here, the reversible regulation of microcosmic structural rigidity is accomplished using a DNA origami device in vitro. The designed DNA origami monomer is composed of an internal central axis and an external sliding tube. Due to the external tube sliding, the device transforms between flexible and rigid states. By transporting the device into the liposome, the conformational change of the origami device induces a structural change in the liposome. The results obtained demonstrate that the programmed DNA origami device can be applied to regulate the microcosmic structural rigidity of liposomes. Because microcosmic structural rigidity is important to cell proliferation and function, the results obtained potentially provide a foundation for the regulation of cell microcosmic structural rigidity using DNA nanostructures. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The effects of nail rigidity on fracture healing in rats with osteoporosis

PubMed Central

Sha, Mo; Fu, Jun; Li, Jing; Fan Yuan, Chao; Shi, Lei; Jun Li, Shu

2009-01-01

Background and purpose Stress shielding from rigid internal fixation may lead to refracture after removal of the osteosynthesis material. We investigated the effect of a low-rigidity (Ti-24Nb-4Zr-7.9Sn) intramedullary nail regarding stress shielding and bone healing of osteoporotic fractures in the rat. Methods 40 female Sprague-Dawley rats, aged 3 months, were divided into the following groups: sham-operation (SHAM) (n = 10), ovariectomized (OVX) (n = 10) and OVX-fracture (n = 20). 10 SHAM rats and 10 OVX rats were killed after 12 weeks to provide biomechanical data. Ovariectomy was performed 12 weeks before fracturing both femurs in 20 rats. The left fracture was stabilized with a high-rigidity titanium alloy pin (Ti-6Al-4V; elastic modulus 110 GPa) and the right with a low-rigidity (Ti-24Nb-4Zr-7.9Sn; elastic modulus 33 GPa). The bony calluses were examined by micro-CT at 6 and 12 weeks after fracture, bone volume (BV) and total volume (TV) were determined at the callus region (ROI1) and the total femur (ROI2). Subsequently, the bones were tested mechanically by a three-point bending test. Results In the low-rigidity group, TV (ROI1) increased at 6 weeks, but BV (ROI1), BV (ROI2) were similar but maximum load increased. At 12 weeks, the maximum load and also BV (ROI1, ROI2) were increased in the low-rigidity group. Interpretation The low-rigidity nail manufactured from Ti-24Nb-4Zr-7.9Sn showed better external callus formation, seemed to reduce effects of stress shielding, and reduced bone resorption better than the stiffer nail. The low-rigidity nail was strong enough to maintain alignment of the fracture in the osteoporotic rat model without delayed union. PMID:19297794

Botulinum toxin in myotonia congenita: it does not help against rigidity and pain.

PubMed

Dressler, Dirk; Adib Saberi, Fereshte

2014-05-01

Botulinum toxin (BT) is a potent local muscle relaxant with analgetic properties. Myotonia congenita (MC) is a genetic disorder producing muscle rigidity and pain. BT injected into the trapezius produced mild paresis, but no effect on rigidity and pain. There were no signs of systemic effects. Lack of BT efficacy on MC rigidity confirms its origin from muscle membrane dysfunction rather than from inappropriate neuromuscular activation. Lack of BT efficacy on pain could be caused by lack of anti-rigidity effect. It could also be due to separate non-muscular pain mechanisms unresponsive to BT.

Calculating ensemble averaged descriptions of protein rigidity without sampling.

PubMed

González, Luis C; Wang, Hui; Livesay, Dennis R; Jacobs, Donald J

2012-01-01

Previous works have demonstrated that protein rigidity is related to thermodynamic stability, especially under conditions that favor formation of native structure. Mechanical network rigidity properties of a single conformation are efficiently calculated using the integer body-bar Pebble Game (PG) algorithm. However, thermodynamic properties require averaging over many samples from the ensemble of accessible conformations to accurately account for fluctuations in network topology. We have developed a mean field Virtual Pebble Game (VPG) that represents the ensemble of networks by a single effective network. That is, all possible number of distance constraints (or bars) that can form between a pair of rigid bodies is replaced by the average number. The resulting effective network is viewed as having weighted edges, where the weight of an edge quantifies its capacity to absorb degrees of freedom. The VPG is interpreted as a flow problem on this effective network, which eliminates the need to sample. Across a nonredundant dataset of 272 protein structures, we apply the VPG to proteins for the first time. Our results show numerically and visually that the rigidity characterizations of the VPG accurately reflect the ensemble averaged [Formula: see text] properties. This result positions the VPG as an efficient alternative to understand the mechanical role that chemical interactions play in maintaining protein stability.

Robust non-rigid registration algorithm based on local affine registration

NASA Astrophysics Data System (ADS)

Wu, Liyang; Xiong, Lei; Du, Shaoyi; Bi, Duyan; Fang, Ting; Liu, Kun; Wu, Dongpeng

2018-04-01

Aiming at the problem that the traditional point set non-rigid registration algorithm has low precision and slow convergence speed for complex local deformation data, this paper proposes a robust non-rigid registration algorithm based on local affine registration. The algorithm uses a hierarchical iterative method to complete the point set non-rigid registration from coarse to fine. In each iteration, the sub data point sets and sub model point sets are divided and the shape control points of each sub point set are updated. Then we use the control point guided affine ICP algorithm to solve the local affine transformation between the corresponding sub point sets. Next, the local affine transformation obtained by the previous step is used to update the sub data point sets and their shape control point sets. When the algorithm reaches the maximum iteration layer K, the loop ends and outputs the updated sub data point sets. Experimental results demonstrate that the accuracy and convergence of our algorithm are greatly improved compared with the traditional point set non-rigid registration algorithms.

Cosmic ray proton spectra at low rigidities

NASA Technical Reports Server (NTRS)

Seo, E. S.; Ormes, J. F.; Streitmatter, R. E.; Lloyd-Evans, J.; Jones, W. V.

1990-01-01

The cosmic ray proton rigidity spectra have been investigated with data collected in the Low Energy Antiproton (LEAP) balloon flight experiment flown from Prince Albert, Canada in 1987. The LEAP apparatus was designed to measure antiprotons using a superconducting magnet spectrometer with ancillary scintillator, time-of-flight, and liquid Cherenkov detectors. After reaching float altitude the balloon drifted south and west to higher geomagnetic cutoffs. The effect of the changing geomagnetic cutoff on the observed spectra was observed during analysis of the proton data along the balloon trajectory. This is the first measurement of the primary and splash albedo spectra over a wide rigidity range (few hundred MV to about 100 GV) with a single instrument.

Disinfection of rigid nasal endoscopes following in vitro contamination with Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Haemophilus influenzae.

PubMed

Bradford, Benjamin D; Seiberling, Kristin A; Park, Francine E; Hiebert, Jared C; Chang, Dennis F

2013-06-01

If not adequately cleaned, rigid nasal endoscopes (RNEs) have the potential to cause iatrogenic cross-contamination. To test the efficacy of various disinfection methods in reducing bacterial load on RNEs in vitro. In vitro model. Staphylococcus aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Haemophilus influenzae contamination was separately induced on RNEs in vitro. Two experimental sets were completed. The RNEs were disinfected using the following protocols: 30-second scrub with antimicrobial soap (ABS) and water, 30-second scrub with 70% isopropyl alcohol (IA), 30-second scrub with ABS followed by 30-second scrub with IA, 30-second scrub with germicidal cloth, isolated 5-minute soak in an enzymatic soap solution, 5- and 10-minute soaks in ortho-phthalaldehyde, 0.55%, solution (Cidex OPA), and isolated 30-second rinse with tap water, all with 30-second precleaning and postcleaning rinses with tap water. Two sets of experiments (experiment sets A and B) were carried out with a 30-second tap water rinse after inoculation of each RNE. This was followed by immediate cleaning in set A and a 1-hour air-dry delay in set B. Otherwise there were no differences in the disinfection protocols between sets for each method noted. Effectiveness of various disinfection protocols in cleaning rigid nasal endoscopes experimentally inoculated with bacteria commonly found in the upper aerodigestive tract. Positive cultures following disinfection indicated ineffective or incomplete disinfection. Most cleaning methods were effective in eliminating S aureus, S pneumoniae, and H influenzae from the scopes following experimental contamination. Continued growth of P aeruginosa was found after all of the disinfection trials in experiment set A with the exception of a 10-minute immersion in Cidex OPA, and in set B except for the 10-minute Cidex OPA immersion and ABS plus IA trials. Most cleaning methods used in our trials appear to properly disinfect RNEs after in vitro

Bang-Bang Practical Stabilization of Rigid Bodies

NASA Astrophysics Data System (ADS)

Serpelloni, Edoardo

In this thesis, we study the problem of designing a practical stabilizer for a rigid body equipped with a set of actuators generating only constant thrust. Our motivation stems from the fact that modern space missions are required to accurately control the position and orientation of spacecraft actuated by constant-thrust jet-thrusters. To comply with the performance limitations of modern thrusters, we design a feedback controller that does not induce high-frequency switching of the actuators. The proposed controller is hybrid and it asymptotically stabilizes an arbitrarily small compact neighborhood of the target position and orientation of the rigid body. The controller is characterized by a hierarchical structure comprising of two control layers. At the low level of the hierarchy, an attitude controller stabilizes the target orientation of the rigid body. At the high level, after the attitude controller has steered the rigid body sufficiently close to its desired orientation, a position controller stabilizes the desired position. The size of the neighborhood being stabilized by the controller can be adjusted via a proper selection of the controller parameters. This allows us to stabilize the rigid body to virtually any degree of accuracy. It is shown that the controller, even in the presence of measurement noise, does not induce high-frequency switching of the actuators. The key component in the design of the controller is a hybrid stabilizer for the origin of double-integrators affected by bounded external perturbations. Specifically, both the position and the attitude stabilizers consist of multiple copies of such a double-integrator controller. The proposed controller is applied to two realistic spacecraft control problems. First, we apply the position controller to the problem of stabilizing the relative position between two spacecraft flying in formation in the vicinity of the L2 libration point of the Sun-Earth system as a part of a large space telescope

Large scale rigidity-based flexibility analysis of biomolecules

PubMed Central

Streinu, Ileana

2016-01-01

KINematics And RIgidity (KINARI) is an on-going project for in silico flexibility analysis of proteins. The new version of the software, Kinari-2, extends the functionality of our free web server KinariWeb, incorporates advanced web technologies, emphasizes the reproducibility of its experiments, and makes substantially improved tools available to the user. It is designed specifically for large scale experiments, in particular, for (a) very large molecules, including bioassemblies with high degree of symmetry such as viruses and crystals, (b) large collections of related biomolecules, such as those obtained through simulated dilutions, mutations, or conformational changes from various types of dynamics simulations, and (c) is intended to work as seemlessly as possible on the large, idiosyncratic, publicly available repository of biomolecules, the Protein Data Bank. We describe the system design, along with the main data processing, computational, mathematical, and validation challenges underlying this phase of the KINARI project. PMID:26958583

Statistical aspects of the TNK-S2B trial of tenecteplase versus alteplase in acute ischemic stroke: an efficient, dose-adaptive, seamless phase II/III design.

PubMed

Levin, Bruce; Thompson, John L P; Chakraborty, Bibhas; Levy, Gilberto; MacArthur, Robert; Haley, E Clarke

2011-08-01

TNK-S2B, an innovative, randomized, seamless phase II/III trial of tenecteplase versus rt-PA for acute ischemic stroke, terminated for slow enrollment before regulatory approval of use of phase II patients in phase III. (1) To review the trial design and comprehensive type I error rate simulations and (2) to discuss issues raised during regulatory review, to facilitate future approval of similar designs. In phase II, an early (24-h) outcome and adaptive sequential procedure selected one of three tenecteplase doses for phase III comparison with rt-PA. Decision rules comparing this dose to rt-PA would cause stopping for futility at phase II end, or continuation to phase III. Phase III incorporated two co-primary hypotheses, allowing for a treatment effect at either end of the trichotomized Rankin scale. Assuming no early termination, four interim analyses and one final analysis of 1908 patients provided an experiment-wise type I error rate of <0.05. Over 1,000 distribution scenarios, each involving 40,000 replications, the maximum type I error in phase III was 0.038. Inflation from the dose selection was more than offset by the one-half continuity correction in the test statistics. Inflation from repeated interim analyses was more than offset by the reduction from the clinical stopping rules for futility at the first interim analysis. Design complexity and evolving regulatory requirements lengthened the review process. (1) The design was innovative and efficient. Per protocol, type I error was well controlled for the co-primary phase III hypothesis tests, and experiment-wise. (2a) Time must be allowed for communications with regulatory reviewers from first design stages. (2b) Adequate type I error control must be demonstrated. (2c) Greater clarity is needed on (i) whether this includes demonstration of type I error control if the protocol is violated and (ii) whether simulations of type I error control are acceptable. (2d) Regulatory agency concerns that protocols

SU-E-J-225: Quantitative Evaluation of Rigid and Non-Rigid Motion of Liver Tumors Using Stereo Imaging During SBRT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xu, Q; Hanna, G; Kubicek, G

2014-06-01

Purpose: To quantitatively evaluate rigid and nonrigid motion of liver tumors based on fiducial tracking in 3D by stereo imaging during CyberKnife SBRT. Methods: Twenty-five liver patients previously treated with three-fractions of SBRT were retrospectively recruited in this study. During treatment, the 3D locations of fiducials were reported by the CyberKnife system after two orthogonal kV X-ray images were taken and further validated by geometry derivations. A total of 5004 pairs of X-ray images acquired during the course of treatment for all the patients, were analyzed. For rigid motion, the rotational angles and translational shifts by aligning 3D fiducial groupsmore » in different image pairs after least-square fitting were reported. For nonrigid motion, the relative interfractional tumor shape variations were reported and correlated to the sum of inter-fiducial distances. The individual fiducial displacements were also reported after rigid corrections and without angle corrections. Results: The relative tumor volume variation indicated by the inter-fiducial distances demonstrated an increasing trend in the second (101.6±3.4%) and third fraction (101.2±5.6%) among most patients. The cause could be possibly due to radiation-induced edema. For all the patients, the translational shift was 8.1±5.7 mm, with shifts in LR, AP and SI were 2.1±2.4 mm, 2.8±2.9 mm and 6.7±5.1 mm, respectively. The greatest translation shift occurred in SI, mainly due the breathing motion of diaphragm The rotational angles were 1.1±1.7°, 1.9±2.6° and 1.6±2.2°, in roll, pitch, and yaw, respectively. The 3D fiducial displacement with rigid corrections were 0.2±0.2 mm and increased to 0.6±0.3 mm without rotational corrections. Conclusion: The fiducial locations in 3D can be precisely reconstructed from CyberKnife stereo imaging system during treatment. The fiducials provide close estimation of both rigid and nonrigid motion of .liver tumors. The reported data could be

Flow properties and hydrodynamic interactions of rigid spherical microswimmers

NASA Astrophysics Data System (ADS)

Adhyapak, Tapan Chandra; Jabbari-Farouji, Sara

2017-11-01

We analyze a minimal model for a rigid spherical microswimmer and explore the consequences of its extended surface on the interplay between its self-propulsion and flow properties. The model is the first order representation of microswimmers, such as bacteria and algae, with rigid bodies and flexible propelling appendages. The flow field of such a microswimmer at finite distances significantly differs from that of a point-force (Stokeslet) dipole. For a suspension of microswimmers, we derive the grand mobility matrix that connects the motion of an individual swimmer to the active and passive forces and torques acting on all the swimmers. Our investigation of the mobility tensors reveals that hydrodynamic interactions among rigid-bodied microswimmers differ considerably from those among the corresponding point-force dipoles. Our results are relevant for the study of collective behavior of hydrodynamically interacting microswimmers by means of Stokesian dynamics simulations at moderate concentrations.

Access to special care dentistry, part 7. Special care dentistry services: seamless care for people in their middle years--part 1.

PubMed

Lewis, D; Fiske, J; Dougall, A

2008-09-27

Children and older people have been relatively well served by specialist dental care. Despite increasing disability amongst people in their middle years, there have been no or few dedicated dental teams with responsibility for provision of their oral care. This article explores the ethos and practicality of seamless care across the age groups and the primary/secondary care interface, with a focus on embedding oral health into general healthcare plans through the multidisciplinary team approach. The article explores four conditions--rheumatoid arthritis, Huntingdon's disease, multiple sclerosis and diabetes. It considers the features of each condition and how they can impact on both oral health and the delivery of dental services. It also considers the elements of care that contribute to a holistic and seamless approach to oral care services.

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype

PubMed Central

Tilghman, Robert W.; Cowan, Catharine R.; Mih, Justin D.; Koryakina, Yulia; Gioeli, Daniel; Slack-Davis, Jill K.; Blackman, Brett R.; Tschumperlin, Daniel J.; Parsons, J. Thomas

2010-01-01

Background The mechanical properties of the extracellular matrix have an important role in cell growth and differentiation. However, it is unclear as to what extent cancer cells respond to changes in the mechanical properties (rigidity/stiffness) of the microenvironment and how this response varies among cancer cell lines. Methodology/Principal Findings In this study we used a recently developed 96-well plate system that arrays extracellular matrix-conjugated polyacrylamide gels that increase in stiffness by at least 50-fold across the plate. This plate was used to determine how changes in the rigidity of the extracellular matrix modulate the biological properties of tumor cells. The cell lines tested fall into one of two categories based on their proliferation on substrates of differing stiffness: “rigidity dependent” (those which show an increase in cell growth as extracellular rigidity is increased), and “rigidity independent” (those which grow equally on both soft and stiff substrates). Cells which grew poorly on soft gels also showed decreased spreading and migration under these conditions. More importantly, seeding the cell lines into the lungs of nude mice revealed that the ability of cells to grow on soft gels in vitro correlated with their ability to grow in a soft tissue environment in vivo. The lung carcinoma line A549 responded to culture on soft gels by expressing the differentiated epithelial marker E-cadherin and decreasing the expression of the mesenchymal transcription factor Slug. Conclusions/Significance These observations suggest that the mechanical properties of the matrix environment play a significant role in regulating the proliferation and the morphological properties of cancer cells. Further, the multiwell format of the soft-plate assay is a useful and effective adjunct to established 3-dimensional cell culture models. PMID:20886123

Distance-preserving rigidity penalty on deformable image registration of multiple skeletal components in the neck

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Jihun, E-mail: jihun@umich.edu; Saitou, Kazuhiro; Matuszak, Martha M.

Purpose: This study aims at developing and testing a novel rigidity penalty suitable for the deformable registration of tightly located skeletal components in the head and neck from planning computed tomography (CT) and daily cone-beam CT (CBCT) scans of patients undergoing radiotherapy. Methods: The proposed rigidity penalty is designed to preserve intervoxel distances within each bony structure. This penalty was tested in the intensity-based B-spline deformable registration of five cervical vertebral bodies (C1–C5). The displacement vector fields (DVFs) from the registrations were compared to the DVFs generated by using rigid body motions of the cervical vertebrae, measured by the surfacemore » registration of vertebrae delineated on CT and CBCT images. Twenty five pairs of planning CT (reference) and treatment CBCTs (target) from five patients were aligned without and with the penalty. An existing penalty based on the orthonormality of the deformation gradient tensor was also tested and the effects of the penalties compared. Results: The mean magnitude of the maximum registration error with the proposed distance-preserving penalty was (0.86, 1.12, 1.33) mm compared to (2.11, 2.49, 2.46) without penalty and (1.53, 1.64, 1.64) with the existing orthonormality-based penalty. The improvement in the accuracy of the deformable image registration was also verified by comparing the Procrustes distance between the DVFs. With the proposed penalty, the average distance was 0.11 (σ 0.03 mm) which is smaller than 0.53 (0.1 mm) without penalty and 0.28 (0.04 mm) with the orthonormality-based penalty. Conclusions: The accuracy of aligning multiple bony elements was improved by using the proposed distance-preserving rigidity penalty. The voxel-based statistical analysis of the registration error shows that the proposed penalty improved the integrity of the DVFs within the vertebral bodies.« less

Distance-preserving rigidity penalty on deformable image registration of multiple skeletal components in the neck

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Jihun, E-mail: jihun@umich.edu; Saitou, Kazuhiro; Matuszak, Martha M.

2013-12-15

Purpose: This study aims at developing and testing a novel rigidity penalty suitable for the deformable registration of tightly located skeletal components in the head and neck from planning computed tomography (CT) and daily cone-beam CT (CBCT) scans of patients undergoing radiotherapy. Methods: The proposed rigidity penalty is designed to preserve intervoxel distances within each bony structure. This penalty was tested in the intensity-based B-spline deformable registration of five cervical vertebral bodies (C1–C5). The displacement vector fields (DVFs) from the registrations were compared to the DVFs generated by using rigid body motions of the cervical vertebrae, measured by the surfacemore » registration of vertebrae delineated on CT and CBCT images. Twenty five pairs of planning CT (reference) and treatment CBCTs (target) from five patients were aligned without and with the penalty. An existing penalty based on the orthonormality of the deformation gradient tensor was also tested and the effects of the penalties compared. Results: The mean magnitude of the maximum registration error with the proposed distance-preserving penalty was (0.86, 1.12, 1.33) mm compared to (2.11, 2.49, 2.46) without penalty and (1.53, 1.64, 1.64) with the existing orthonormality-based penalty. The improvement in the accuracy of the deformable image registration was also verified by comparing the Procrustes distance between the DVFs. With the proposed penalty, the average distance was 0.11 (σ 0.03 mm) which is smaller than 0.53 (0.1 mm) without penalty and 0.28 (0.04 mm) with the orthonormality-based penalty. Conclusions: The accuracy of aligning multiple bony elements was improved by using the proposed distance-preserving rigidity penalty. The voxel-based statistical analysis of the registration error shows that the proposed penalty improved the integrity of the DVFs within the vertebral bodies.« less

Brownian dynamics of confined rigid bodies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Delong, Steven; Balboa Usabiaga, Florencio; Donev, Aleksandar, E-mail: donev@courant.nyu.edu

2015-10-14

We introduce numerical methods for simulating the diffusive motion of rigid bodies of arbitrary shape immersed in a viscous fluid. We parameterize the orientation of the bodies using normalized quaternions, which are numerically robust, space efficient, and easy to accumulate. We construct a system of overdamped Langevin equations in the quaternion representation that accounts for hydrodynamic effects, preserves the unit-norm constraint on the quaternion, and is time reversible with respect to the Gibbs-Boltzmann distribution at equilibrium. We introduce two schemes for temporal integration of the overdamped Langevin equations of motion, one based on the Fixman midpoint method and the othermore » based on a random finite difference approach, both of which ensure that the correct stochastic drift term is captured in a computationally efficient way. We study several examples of rigid colloidal particles diffusing near a no-slip boundary and demonstrate the importance of the choice of tracking point on the measured translational mean square displacement (MSD). We examine the average short-time as well as the long-time quasi-two-dimensional diffusion coefficient of a rigid particle sedimented near a bottom wall due to gravity. For several particle shapes, we find a choice of tracking point that makes the MSD essentially linear with time, allowing us to estimate the long-time diffusion coefficient efficiently using a Monte Carlo method. However, in general, such a special choice of tracking point does not exist, and numerical techniques for simulating long trajectories, such as the ones we introduce here, are necessary to study diffusion on long time scales.« less

Apparatus for integrating a rigid structure into a flexible wall of an inflatable structure

NASA Technical Reports Server (NTRS)

Johnson, Christopher J. (Inventor); Patterson, Ross M. (Inventor); Spexarth, Gary R. (Inventor)

2009-01-01

For an inflatable structure having a flexible outer shell or wall structure having a flexible restraint layer comprising interwoven, load-bearing straps, apparatus for integrating one or more substantially rigid members into the flexible shell. For each rigid member, a corresponding opening is formed through the flexible shell for receiving the rigid member. A plurality of connection devices are mounted on the rigid member for receiving respective ones of the load-bearing straps. In one embodiment, the connection devices comprise inner connecting mechanisms and outer connecting mechanisms, the inner and outer connecting mechanisms being mounted on the substantially rigid structure and spaced along a peripheral edge portion of the structure in an interleafed array in which respective outer connecting mechanisms are interposed between adjacent pairs of inner connecting mechanisms, the outer connecting mechanisms projecting outwardly from the peripheral edge portion of the substantially rigid structure beyond the adjacent inner connecting mechanisms to form a staggered array of connecting mechanisms extending along the panel structure edge portion. In one embodiment, the inner and outer connecting mechanisms form part of an integrated, structure rotatably mounted on the rigid member peripheral edge portion.

Non-rigid Reconstruction of Casting Process with Temperature Feature

NASA Astrophysics Data System (ADS)

Lin, Jinhua; Wang, Yanjie; Li, Xin; Wang, Ying; Wang, Lu

2017-09-01

Off-line reconstruction of rigid scene has made a great progress in the past decade. However, the on-line reconstruction of non-rigid scene is still a very challenging task. The casting process is a non-rigid reconstruction problem, it is a high-dynamic molding process lacking of geometric features. In order to reconstruct the casting process robustly, an on-line fusion strategy is proposed for dynamic reconstruction of casting process. Firstly, the geometric and flowing feature of casting are parameterized in manner of TSDF (truncated signed distance field) which is a volumetric block, parameterized casting guarantees real-time tracking and optimal deformation of casting process. Secondly, data structure of the volume grid is extended to have temperature value, the temperature interpolation function is build to generate the temperature of each voxel. This data structure allows for dynamic tracking of temperature of casting during deformation stages. Then, the sparse RGB features is extracted from casting scene to search correspondence between geometric representation and depth constraint. The extracted color data guarantees robust tracking of flowing motion of casting. Finally, the optimal deformation of the target space is transformed into a nonlinear regular variational optimization problem. This optimization step achieves smooth and optimal deformation of casting process. The experimental results show that the proposed method can reconstruct the casting process robustly and reduce drift in the process of non-rigid reconstruction of casting.

Extracting a Purely Non-rigid Deformation Field of a Single Structure

NASA Astrophysics Data System (ADS)

Demirci, Stefanie; Manstad-Hulaas, Frode; Navab, Nassir

During endovascular aortic repair (EVAR) treatment, the aortic shape is subject to severe deformation that is imposed by medical instruments such as guide wires, catheters, and the stent graft. The problem definition of deformable registration of images covering the entire abdominal region, however, is highly ill-posed. We present a new method for extracting the deformation of an aneurysmatic aorta. The outline of the procedure includes initial rigid alignment of two abdominal scans, segmentation of abdominal vessel trees, and automatic reduction of their centerline structures to one specified region of interest around the aorta. Our non-rigid registration procedure then only computes local non-rigid deformation and leaves out all remaining global rigid transformations. In order to evaluate our method, experiments for the extraction of aortic deformation fields are conducted on 15 patient datasets from endovascular aortic repair (EVAR) treatment. A visual assessment of the registration results were performed by two vascular surgeons and one interventional radiologist who are all experts in EVAR procedures.

Method for identification of rigid domains and hinge residues in proteins based on exhaustive enumeration.

PubMed

Sim, Jaehyun; Sim, Jun; Park, Eunsung; Lee, Julian

2015-06-01

Many proteins undergo large-scale motions where relatively rigid domains move against each other. The identification of rigid domains, as well as the hinge residues important for their relative movements, is important for various applications including flexible docking simulations. In this work, we develop a method for protein rigid domain identification based on an exhaustive enumeration of maximal rigid domains, the rigid domains not fully contained within other domains. The computation is performed by mapping the problem to that of finding maximal cliques in a graph. A minimal set of rigid domains are then selected, which cover most of the protein with minimal overlap. In contrast to the results of existing methods that partition a protein into non-overlapping domains using approximate algorithms, the rigid domains obtained from exact enumeration naturally contain overlapping regions, which correspond to the hinges of the inter-domain bending motion. The performance of the algorithm is demonstrated on several proteins. © 2015 Wiley Periodicals, Inc.

Rationally designed graphene-nanotube 3D architectures with a seamless nodal junction for efficient energy conversion and storage

PubMed Central

Xue, Yuhua; Ding, Yong; Niu, Jianbing; Xia, Zhenhai; Roy, Ajit; Chen, Hao; Qu, Jia; Wang, Zhong Lin; Dai, Liming

2015-01-01

One-dimensional (1D) carbon nanotubes (CNTs) and 2D single-atomic layer graphene have superior thermal, electrical, and mechanical properties. However, these nanomaterials exhibit poor out-of-plane properties due to the weak van der Waals interaction in the transverse direction between graphitic layers. Recent theoretical studies indicate that rationally designed 3D architectures could have desirable out-of-plane properties while maintaining in-plane properties by growing CNTs and graphene into 3D architectures with a seamless nodal junction. However, the experimental realization of seamlessly-bonded architectures remains a challenge. We developed a strategy of creating 3D graphene-CNT hollow fibers with radially aligned CNTs (RACNTs) seamlessly sheathed by a cylindrical graphene layer through a one-step chemical vapor deposition using an anodized aluminum wire template. By controlling the aluminum wire diameter and anodization time, the length of the RACNTs and diameter of the graphene hollow fiber can be tuned, enabling efficient energy conversion and storage. These fibers, with a controllable surface area, meso-/micropores, and superior electrical properties, are excellent electrode materials for all-solid-state wire-shaped supercapacitors with poly(vinyl alcohol)/H2SO4 as the electrolyte and binder, exhibiting a surface-specific capacitance of 89.4 mF/cm2 and length-specific capacitance up to 23.9 mF/cm, — one to four times the corresponding record-high capacities reported for other fiber-like supercapacitors. Dye-sensitized solar cells, fabricated using the fiber as a counter electrode, showed a power conversion efficiency of 6.8% and outperformed their counterparts with an expensive Pt wire counter electrode by a factor of 2.5. These novel fiber-shaped graphene-RACNT energy conversion and storage devices are so flexible they can be woven into fabrics as power sources. PMID:26601246

Rationally designed graphene-nanotube 3D architectures with a seamless nodal junction for efficient energy conversion and storage.

PubMed

Xue, Yuhua; Ding, Yong; Niu, Jianbing; Xia, Zhenhai; Roy, Ajit; Chen, Hao; Qu, Jia; Wang, Zhong Lin; Dai, Liming

2015-09-01

One-dimensional (1D) carbon nanotubes (CNTs) and 2D single-atomic layer graphene have superior thermal, electrical, and mechanical properties. However, these nanomaterials exhibit poor out-of-plane properties due to the weak van der Waals interaction in the transverse direction between graphitic layers. Recent theoretical studies indicate that rationally designed 3D architectures could have desirable out-of-plane properties while maintaining in-plane properties by growing CNTs and graphene into 3D architectures with a seamless nodal junction. However, the experimental realization of seamlessly-bonded architectures remains a challenge. We developed a strategy of creating 3D graphene-CNT hollow fibers with radially aligned CNTs (RACNTs) seamlessly sheathed by a cylindrical graphene layer through a one-step chemical vapor deposition using an anodized aluminum wire template. By controlling the aluminum wire diameter and anodization time, the length of the RACNTs and diameter of the graphene hollow fiber can be tuned, enabling efficient energy conversion and storage. These fibers, with a controllable surface area, meso-/micropores, and superior electrical properties, are excellent electrode materials for all-solid-state wire-shaped supercapacitors with poly(vinyl alcohol)/H2SO4 as the electrolyte and binder, exhibiting a surface-specific capacitance of 89.4 mF/cm(2) and length-specific capacitance up to 23.9 mF/cm, - one to four times the corresponding record-high capacities reported for other fiber-like supercapacitors. Dye-sensitized solar cells, fabricated using the fiber as a counter electrode, showed a power conversion efficiency of 6.8% and outperformed their counterparts with an expensive Pt wire counter electrode by a factor of 2.5. These novel fiber-shaped graphene-RACNT energy conversion and storage devices are so flexible they can be woven into fabrics as power sources.

Development of a counterselectable seamless mutagenesis system in lactic acid bacteria.

PubMed

Xin, Yongping; Guo, Tingting; Mu, Yingli; Kong, Jian

2017-07-05

Lactic acid bacteria (LAB) are receiving more attention to act as cell factories for the production of high-value metabolites. However, the molecular tools for genetic modifying these strains are mainly vector-based double-crossover strategies, which are laborious and inefficient. To address this problem, several counterselectable markers have been developed, while few of them could be used in the wild-type host cells without pretreatment. The pheS gene encoding phenylalanyl-tRNA synthetase alpha subunit was identified in Lactococcus lactis NZ9000 genome. When mutant pheS gene (pheS*) under the control of the Lc. lactis NZ9000 L-lactate dehydrogenase promoter (P ldh ) was expressed from a plasmid, the resulted PheS* with an A312G substitution rendered cells sensitive to the phenylalanine analog p-chloro-phenylalanine (p-Cl-Phe). This result suggested pheS* was suitable to be used as a counterselectable marker in Lc. lactis. However, the expression level of pheS* from a chromosomal copy was too low to confer p-Cl-Phe sensitivity. Therefore, a strategy of cascading promoters was attempted for strengthening the expression level of pheS*. Expectedly, a cassette 5Pldh-pheS* with five tandem repetitive promoters P ldh resulted in a sensitivity to 15 mM p-Cl-Phe. Subsequently, a counterselectable seamless mutagenesis system PheS*/pG + host9 based on a temperature-sensitive plasmid pG + host9 harboring a 5Pldh-pheS* cassette was developed in Lc. lactis. We also demonstrated the possibility of applying pheS* to be a counterselectable marker in Lactobacillus casei BL23. As reported in E. coli, pheS* as a counterselectable marker has been demonstrated to be functional in targeted gene(s) deletion in Lc. lactis as well as in L. casei. Moreover, the efficiency and timesaving counterselectable seamless mutagenesis system PheS*/pG + host9 could be used in the wild-type host cells without pretreatment.

Rigid bronchoscopy and silicone stents in the management of central airway obstruction

PubMed Central

Yarmus, Lonny

2015-01-01

The field of interventional pulmonology has grown significantly over the past several decades now including the diagnosis and therapeutic treatment of complex airway disease. Rigid bronchoscopy is an invaluable tool in the diagnosis and management of several malignant and non-malignant causes of central airway obstruction (CAO) and has become integral after the inception of airway stenting. The management of CAO can be a complicated endeavor with significant risks making the understanding of basic rigid bronchoscopy techniques, ablative technologies, anesthetic care and stenting of utmost importance in the care of these complex patients. This review article will focus on the history of rigid bronchoscopy, the technical aspects of performing a rigid bronchoscopy as well as the use of silicone stents their indications, complications and placement techniques. PMID:26807283

Rigid porous filter

DOEpatents

Chiang, Ta-Kuan; Straub, Douglas L.; Dennis, Richard A.

2000-01-01

The present invention involves a porous rigid filter including a plurality of concentric filtration elements having internal flow passages and forming external flow passages there between. The present invention also involves a pressure vessel containing the filter for the removal of particulates from high pressure particulate containing gases, and further involves a method for using the filter to remove such particulates. The present filter has the advantage of requiring fewer filter elements due to the high surface area-to-volume ratio provided by the filter, requires a reduced pressure vessel size, and exhibits enhanced mechanical design properties, improved cleaning properties, configuration options, modularity and ease of fabrication.

47 CFR 22.861 - Emission limitations.

Code of Federal Regulations, 2011 CFR

2011-10-01

... below the transmitting power (P) by a factor of at least 43 + 10 log (P) dB. (b) Measurement procedure... maintain a copy of the contract in their station files and disclose it to prospective assignees or...

Availability improvement of layer 2 seamless networks using OpenFlow.

PubMed

Molina, Elias; Jacob, Eduardo; Matias, Jon; Moreira, Naiara; Astarloa, Armando

2015-01-01

The network robustness and reliability are strongly influenced by the implementation of redundancy and its ability of reacting to changes. In situations where packet loss or maximum latency requirements are critical, replication of resources and information may become the optimal technique. To this end, the IEC 62439-3 Parallel Redundancy Protocol (PRP) provides seamless recovery in layer 2 networks by delegating the redundancy management to the end-nodes. In this paper, we present a combination of the Software-Defined Networking (SDN) approach and PRP topologies to establish a higher level of redundancy and thereby, through several active paths provisioned via the OpenFlow protocol, the global reliability is increased, as well as data flows are managed efficiently. Hence, the experiments with multiple failure scenarios, which have been run over the Mininet network emulator, show the improvement in the availability and responsiveness over other traditional technologies based on a single active path.

The effect of rigid and non-rigid connections between implants and teeth on biological and technical complications: a systematic review and a meta-analysis.

PubMed

Tsaousoglou, Phoebus; Michalakis, Konstantinos; Kang, Kiho; Weber, Hans-Peter; Sculean, Anton

2017-07-01

To assess survival, as well as technical and biological complication rates of partial fixed dental prostheses (FDPs) supported by implants and teeth. An electronic Medline search was conducted to identify articles, published in dental journals from January 1980 to August 2015, reporting on partial FDPs supported by implants and teeth. The search terms were categorized into four groups comprising the PICO question. Manual searches of published full-text articles and related reviews were also performed. The initial database search produced 3587 relevant titles. Three hundred and eighty-six articles were retrieved for abstract review, while 39 articles were selected for full-text review. A total of 10 studies were selected for inclusion. Overall survival rate for implants ranged between 90% and 100%, after follow-up periods with a mean range of 18-120 months. The survival of the abutment teeth was 94.1-100%, while the prostheses survival was 85-100% for the same time period. The most frequent complications were "periapical lesions" (11.53%). The most frequent technical complication was "porcelain occlusal fracture" (16.6%), followed by "screw loosening" (15%). According to the meta-analysis, no intrusion was noted on the rigid connection group, while five teeth (8.19%) were intruded in the non-rigid connection group [95% CI (0.013-0.151)]. The tooth-implant FDP seems to be a possible alternative to an implant-supported FDP. There is limited evidence that rigid connection between teeth and implants presents better results when compared with the non-rigid one. The major drawback of non-rigidly connected FDPs is tooth intrusion. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Pressure-release versus rigid reflector for extracorporeal shockwave lithotripsy.

PubMed

Loske, Achim M; Prieto, Fernando E

2002-06-01

To evaluate the advantages and disadvantages of using a pressure-release reflector instead of a rigid reflector to concentrate shockwaves for extracorporeal shockwave lithotripsy (SWL). As in all electrohydraulic lithotripters, shockwaves were generated by electrical breakdown of water between two electrodes, located at the focus (F1) closest to a paraellipsoidal reflector. A pressure-release reflector, made out of polyurethane foam, was constructed and tested on a research lithotripter using kidney stone models. Fragmentation data and pressure measurements were compared with those of a conventional rigid reflector tested on the same device. The weight of stone model fragments remaining after shockwave exposure was less with the pressure-release reflector after screening through a 3.0 x 3.0-mm mesh. The residual fragment weight was less with the rigid reflector using 1.0 x 1.0- and 0.6 x 0.6-mm meshes. Pressure-release reflectors may maintain acceptable stone fragmentation while offering improved patient safety and should be considered for SWL.

A data seamless interaction scheme between electric power secondary business systems

NASA Astrophysics Data System (ADS)

Ai, Wenkai; Qian, Feng

2018-03-01

At present, the data interaction of electric power secondary business systems is very high, and it is not universal to develop programs when data interaction is carried out by different manufacturers' electric power secondary business systems. There are different interaction schemes for electric power secondary business systems with different manufacturers, which lead to high development cost, low reusability and high maintenance difficulty. This paper introduces a new data seamless interaction scheme between electric power secondary business systems. The scheme adopts the international common Java message service protocol as the transmission protocol, adopts the common JavaScript object symbol format as the data interactive format, unified electric power secondary business systems data interactive way, improve reusability, reduce complexity, monitor the operation of the electric power secondary business systems construction has laid a solid foundation.

Seamless Management of Paper and Electronic Documents for Task Knowledge Sharing

NASA Astrophysics Data System (ADS)

Kojima, Hiroyuki; Iwata, Ken

Due to the progress of Internet technology and the increase of distributed information on networks, the present knowledge management has been based more and more on the performance of various experienced users. In addition to the increase of electronic documents, the use of paper documents has not been reduced because of their convenience. This paper describes a method of tracking paper document locations and contents using radio frequency identification (RFID) technology. This research also focuses on the expression of a task process and the seamless structuring of related electronic and paper documents as a result of task knowledge formalization using information organizing. A system is proposed here that implements information organization for both Web documents and paper documents with the task model description and RFID technology. Examples of a prototype system are also presented.

Dimensional Metrology of Non-rigid Parts Without Specialized Inspection Fixtures =

NASA Astrophysics Data System (ADS)

Sabri, Vahid

Quality control is an important factor for manufacturing companies looking to prosper in an era of globalization, market pressures and technological advances. Functionality and product quality cannot be guaranteed without this important aspect. Manufactured parts have deviations from their nominal (CAD) shape caused by the manufacturing process. Thus, geometric inspection is a very important element in the quality control of mechanical parts. We will focus here on the geometric inspection of non-rigid (flexible) parts which are widely used in the aeronautic and automotive industries. Non-rigid parts can have different forms in a free-state condition compared with their nominal models due to residual stress and gravity loads. To solve this problem, dedicated inspection fixtures are generally used in industry to compensate for the displacement of such parts for simulating the use state in order to perform geometric inspections. These fixtures and the installation and inspection processes are expensive and time-consuming. Our aim in this thesis is therefore to develop an inspection method which eliminates the need for specialized fixtures. This is done by acquiring a point cloud from the part in a free-state condition using a contactless measuring device such as optical scanning and comparing it with the CAD model for the deviation identification. Using a non-rigid registration method and finite element analysis, we numerically inspect the profile of a non-rigid part. To do so, a simulated displacement is performed using an improved definition of displacement boundary conditions for simulating unfixed parts. In addition, we propose a numerical method for dimensional metrology of non-rigid parts in a free-state condition based on the arc length measurement by calculating the geodesic distance using the Fast Marching Method (FMM). In this thesis, we apply our developed methods on industrial non-rigid parts with free-form surfaces simulated with different types of

The influence of joint rigidity on impact efficiency and ball velocity in football kicking.

PubMed

Peacock, James C A; Ball, Kevin

2018-04-11

Executing any skill with efficiency is important for performance. In football kicking, conflicting and non-significant results have existed between reducing ankle plantarflexion during foot-ball contact with impact efficiency, making it unclear as to its importance as a coaching instruction. The aims of this study were to first validate a mechanical kicking machine with a non-rigid ankle, and secondly compare a rigid to a non-rigid ankle during the impact phase of football kicking. Measures of foot-ball contact for ten trials per ankle configuration were calculated from data recorded at 4000 Hz and compared. The non-rigid ankle was characterised by initial dorsiflexion followed by plantarflexion for the remainder of impact, and based on similarities to punt and instep kicking, was considered valid. Impact efficiency (foot-to-ball speed ratio) was greater for the rigid ankle (rigid = 1.16 ± 0.02; non-rigid = 1.10 ± 0.01; p < 0.001). The rigid ankle was characterised by significantly greater effective mass and significantly less energy losses. Increasing rigidity allowed a greater portion of mass from the shank to be used during the collision. As the ankle remained in plantarflexion at impact end, stored elastic energy was not converted to ball velocity and was considered lost. Increasing rigidity is beneficial for increasing impact efficiency, and therefore ball velocity. Copyright © 2018 Elsevier Ltd. All rights reserved.

A rigid and weathered ice shell on Titan.

PubMed

Hemingway, D; Nimmo, F; Zebker, H; Iess, L

2013-08-29

Several lines of evidence suggest that Saturn's largest moon, Titan, has a global subsurface ocean beneath an outer ice shell 50 to 200 kilometres thick. If convection is occurring, the rigid portion of the shell is expected to be thin; similarly, a weak, isostatically compensated shell has been proposed to explain the observed topography. Here we report a strong inverse correlation between gravity and topography at long wavelengths that are not dominated by tides and rotation. We argue that negative gravity anomalies (mass deficits) produced by crustal thickening at the base of the ice shell overwhelm positive gravity anomalies (mass excesses) produced by the small surface topography, giving rise to this inverse correlation. We show that this situation requires a substantially rigid ice shell with an elastic thickness exceeding 40 kilometres, and hundreds of metres of surface erosion and deposition, consistent with recent estimates from local features. Our results are therefore not compatible with a geologically active, low-rigidity ice shell. After extrapolating to wavelengths that are controlled by tides and rotation, we suggest that Titan's moment of inertia may be even higher (that is, Titan may be even less centrally condensed) than is currently thought.

Learning intervention-induced deformations for non-rigid MR-CT registration and electrode localization in epilepsy patients

PubMed Central

Onofrey, John A.; Staib, Lawrence H.; Papademetris, Xenophon

2015-01-01

This paper describes a framework for learning a statistical model of non-rigid deformations induced by interventional procedures. We make use of this learned model to perform constrained non-rigid registration of pre-procedural and post-procedural imaging. We demonstrate results applying this framework to non-rigidly register post-surgical computed tomography (CT) brain images to pre-surgical magnetic resonance images (MRIs) of epilepsy patients who had intra-cranial electroencephalography electrodes surgically implanted. Deformations caused by this surgical procedure, imaging artifacts caused by the electrodes, and the use of multi-modal imaging data make non-rigid registration challenging. Our results show that the use of our proposed framework to constrain the non-rigid registration process results in significantly improved and more robust registration performance compared to using standard rigid and non-rigid registration methods. PMID:26900569

The Influence of Mechanical Parameters on Dielectric Characteristics of Rigid Electrical Insulating Materials

NASA Astrophysics Data System (ADS)

Buică, G.; Antonov, A. E.; Beiu, C.; Dobra, R.; Risteiu, M.

2018-06-01

Rigid electrical insulating materials are used in the manufacture of work equipment with electric safety function, being mainly intended for use in the energy sector. The paper presents the results of the research on the identification of the technical and safety requirements for rigid electrical insulating materials that are part of the electrical insulating work equipment. The paper aims to show the behaviour of rigid electrical insulating materials under the influence of mechanical risk factors, in order to check the functionality and to ensure the safety function for the entire life time. There were tested rigid electrical insulating equipment designed to be used as safety means in electrical power stations and overhead power lines.

Adaptive seamless designs: selection and prospective testing of hypotheses.

PubMed

Jennison, Christopher; Turnbull, Bruce W

2007-01-01

There is a current trend towards clinical protocols which involve an initial "selection" phase followed by a hypothesis testing phase. The selection phase may involve a choice between competing treatments or different dose levels of a drug, between different target populations, between different endpoints, or between a superiority and a non-inferiority hypothesis. Clearly there can be benefits in elapsed time and economy in organizational effort if both phases can be designed up front as one experiment, with little downtime between phases. Adaptive designs have been proposed as a way to handle these selection/testing problems. They offer flexibility and allow final inferences to depend on data from both phases, while maintaining control of overall false positive rates. We review and critique the methods, give worked examples and discuss the efficiency of adaptive designs relative to more conventional procedures. Where gains are possible using the adaptive approach, a variety of logistical, operational, data handling and other practical difficulties remain to be overcome if adaptive, seamless designs are to be effectively implemented.

Deployment, Foam Rigidization, and Structural Characterization of Inflatable Thin-Film Booms

NASA Technical Reports Server (NTRS)

Schnell, Andrew R.; Leigh, Larry M., Jr.; Tinker, Michael L.; McConnaughey, Paul R. (Technical Monitor)

2002-01-01

Detailed investigation of the construction, packaging/deployment, foam rigidization, and structural characterization of polyimide film inflatable booms is described. These structures have considerable potential for use in space with solar concentrators, solar sails, space power systems including solar arrays, and other future missions. Numerous thin-film booms or struts were successfully constructed, inflated, injected with foam, and rigidized. Both solid-section and annular test articles were fabricated, using Kapton polyimide film, various adhesives, Styrofoam end plugs, and polyurethane pressurized foam. Numerous inflation/deployment experiments were conducted and compared to computer simulations using the MSC/DYTRAN code. Finite element models were developed for several foam-rigidized struts and compared to model test results. Several problems encountered in the construction, deployment, and foam injection/rigidization process are described. Areas of difficulty included inadequate adhesive strength, cracking of the film arid leakage, excessive bending of the structure during deployment, problems with foam distribution and curing properties, and control of foam leakage following injection into the structure. Many of these problems were overcome in the course of the research.

Structures of mesophilic and extremophilic citrate synthases reveal rigidity and flexibility for function.

PubMed

Wells, Stephen A; Crennell, Susan J; Danson, Michael J

2014-10-01

Citrate synthase (CS) catalyses the entry of carbon into the citric acid cycle and is highly-conserved structurally across the tree of life. Crystal structures of dimeric CSs are known in both "open" and "closed" forms, which differ by a substantial domain motion that closes the substrate-binding clefts. We explore both the static rigidity and the dynamic flexibility of CS structures from mesophilic and extremophilic organisms from all three evolutionary domains. The computational expense of this wide-ranging exploration is kept to a minimum by the use of rigidity analysis and rapid all-atom simulations of flexible motion, combining geometric simulation and elastic network modeling. CS structures from thermophiles display increased structural rigidity compared with the mesophilic enzyme. A CS structure from a psychrophile, stabilized by strong ionic interactions, appears to display likewise increased rigidity in conventional rigidity analysis; however, a novel modified analysis, taking into account the weakening of the hydrophobic effect at low temperatures, shows a more appropriate decreased rigidity. These rigidity variations do not, however, affect the character of the flexible dynamics, which are well conserved across all the structures studied. Simulation trajectories not only duplicate the crystallographically observed symmetric open-to-closed transitions, but also identify motions describing a previously unidentified antisymmetric functional motion. This antisymmetric motion would not be directly observed in crystallography but is revealed as an intrinsic property of the CS structure by modeling of flexible motion. This suggests that the functional motion closing the binding clefts in CS may be independent rather than symmetric and cooperative. © 2014 Wiley Periodicals, Inc.

Topology-Preserving Rigid Transformation of 2D Digital Images.

PubMed

Ngo, Phuc; Passat, Nicolas; Kenmochi, Yukiko; Talbot, Hugues

2014-02-01

We provide conditions under which 2D digital images preserve their topological properties under rigid transformations. We consider the two most common digital topology models, namely dual adjacency and well-composedness. This paper leads to the proposal of optimal preprocessing strategies that ensure the topological invariance of images under arbitrary rigid transformations. These results and methods are proved to be valid for various kinds of images (binary, gray-level, label), thus providing generic and efficient tools, which can be used in particular in the context of image registration and warping.

Aerial ultrasound source with a circular vibrating plate attached to a rigid circumferential wall

NASA Astrophysics Data System (ADS)

Kuratomi, Ryo; Asami, Takuya; Miura, Hikaru

2018-07-01

We fabricate a transverse vibrating plate attached to a rigid wall integrated at the circumference of a circular vibrating plate that allows a strong sound wave field to be formed in the area encoded by the vibrating plate and rigid wall by installing a wall such as a reflective plate on the rigid wall. The design method for the circular vibrating plate attached to a rigid circumferential wall is investigated. A method of forming a strong standing wave field in an enclosed area constructed with a vibrating plate, cylindrical reflective plate, and parallel reflective plate is developed.

Acoustic scattering of a cylindrical quasi-Gaussian beam with arbitrary incidence focused on a rigid elliptical cylinder

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mitri, F. G., E-mail: F.G.Mitri@ieee.org

2015-11-14

Using the partial-wave series expansion method in cylindrical coordinates, a formal analytical solution for the acoustical scattering of a 2D cylindrical quasi-Gaussian beam with an arbitrary angle of incidence θ{sub i}, focused on a rigid elliptical cylinder in a non-viscous fluid, is developed. The cylindrical focused beam expression is an exact solution of the Helmholtz equation. The scattering coefficients for the elliptical cylinder are determined by forcing the expression of the total (incident + scattered) field to satisfy the Neumann boundary condition for a rigid immovable surface, and performing the product of matrices involving an inversion procedure. Computations for the matrices elementsmore » require a single numerical integration procedure for each partial-wave mode. Numerical results are performed with particular emphasis on the focusing properties of the incident beam and its angle of incidence with respect to the major axis a of the ellipse as well as the aspect ratio a/b where b is the minor axis (assuming a > b). The method is validated and verified against previous results obtained via the T-matrix for plane waves. The present analysis is the first to consider an acoustical beam on an elliptic cylinder of variable cross-section as opposed to plane waves of infinite extent. Other 2D non-spherical and Chebyshev surfaces are mentioned that may be examined throughout this analytical formalism assuming a small deformation parameter ε.« less

Availability Improvement of Layer 2 Seamless Networks Using OpenFlow

PubMed Central

Molina, Elias; Jacob, Eduardo; Matias, Jon; Moreira, Naiara; Astarloa, Armando

2015-01-01

The network robustness and reliability are strongly influenced by the implementation of redundancy and its ability of reacting to changes. In situations where packet loss or maximum latency requirements are critical, replication of resources and information may become the optimal technique. To this end, the IEC 62439-3 Parallel Redundancy Protocol (PRP) provides seamless recovery in layer 2 networks by delegating the redundancy management to the end-nodes. In this paper, we present a combination of the Software-Defined Networking (SDN) approach and PRP topologies to establish a higher level of redundancy and thereby, through several active paths provisioned via the OpenFlow protocol, the global reliability is increased, as well as data flows are managed efficiently. Hence, the experiments with multiple failure scenarios, which have been run over the Mininet network emulator, show the improvement in the availability and responsiveness over other traditional technologies based on a single active path. PMID:25759861

Flow dynamics in pediatric rigid bronchoscopes using computer-aided design modeling software.

PubMed

Barneck, Mitchell D; Webb, J Taylor; Robinson, Ryan E; Grimmer, J Fredrik

2016-08-01

Observed complications during rigid bronchoscopy, including hypercarbia and hypoxemia, prompted us to assess how well rigid bronchoscopes serve as an airway device. We performed computer-aided design flow analysis of pediatric rigid bronchoscopes to gain insight into flow dynamics. We made accurate three-dimensional computer models of pediatric rigid bronchoscopes and endotracheal tubes. SOLIDWORKS (Dassault Systemes, Vélizy-Villacoublay, France) flow analysis software was used to analyze fluid dynamics during pressure-controlled and volume-controlled ventilation. Flow analysis was performed on rigid bronchoscopes and similar outer diameter endotracheal tubes comparing resistance, flow, and turbulence during two ventilation modalities and in common surgical scenarios. Increased turbulent flow was observed in bronchoscopes compared to more laminar flow in endotracheal tubes of similar outer diameter. Flow analysis displayed higher resistances in all pediatric bronchoscope sizes except one (3.0 bronchoscope) compared to similar-sized endotracheal tubes. Loss of adequate ventilation was observed if the bronchoscope was not assembled correctly or if increased peak inspiratory pressures were needed. Anesthesia flow to the patient was reduced by 63% during telescope insertion. Flow analysis illustrates increased turbulent flow and increased airflow resistance in all but one size of pediatric bronchoscopes compared to endotracheal tubes. This increased turbulence and resistance, along with the unanticipated gas distal exit pattern, may contribute to the documented hypercarbia and hypoxemia during procedures. These findings may explain why hypoxemia and hypercarbia are commonly observed during rigid bronchoscopy, especially when positive pressure ventilation is needed. NA Laryngoscope, 126:1940-1945, 2016. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.

Seamless Warping of Diffusion Tensor Fields

PubMed Central

Hao, Xuejun; Bansal, Ravi; Plessen, Kerstin J.; Peterson, Bradley S.

2008-01-01

To warp diffusion tensor fields accurately, tensors must be reoriented in the space to which the tensors are warped based on both the local deformation field and the orientation of the underlying fibers in the original image. Existing algorithms for warping tensors typically use forward mapping deformations in an attempt to ensure that the local deformations in the warped image remains true to the orientation of the underlying fibers; forward mapping, however, can also create “seams” or gaps and consequently artifacts in the warped image by failing to define accurately the voxels in the template space where the magnitude of the deformation is large (e.g., |Jacobian| > 1). Backward mapping, in contrast, defines voxels in the template space by mapping them back to locations in the original imaging space. Backward mapping allows every voxel in the template space to be defined without the creation of seams, including voxels in which the deformation is extensive. Backward mapping, however, cannot reorient tensors in the template space because information about the directional orientation of fiber tracts is contained in the original, unwarped imaging space only, and backward mapping alone cannot transfer that information to the template space. To combine the advantages of forward and backward mapping, we propose a novel method for the spatial normalization of diffusion tensor (DT) fields that uses a bijection (a bidirectional mapping with one-to-one correspondences between image spaces) to warp DT datasets seamlessly from one imaging space to another. Once the bijection has been achieved and tensors have been correctly relocated to the template space, we can appropriately reorient tensors in the template space using a warping method based on Procrustean estimation. PMID:18334425

Modeling the Flexural Rigidity of Rod Photoreceptors

PubMed Central

Haeri, Mohammad; Knox, Barry E.; Ahmadi, Aphrodite

2013-01-01

In vertebrate eyes, the rod photoreceptor has a modified cilium with an extended cylindrical structure specialized for phototransduction called the outer segment (OS). The OS has numerous stacked membrane disks and can bend or break when subjected to mechanical forces. The OS exhibits axial structural variation, with extended bands composed of a few hundred membrane disks whose thickness is diurnally modulated. Using high-resolution confocal microscopy, we have observed OS flexing and disruption in live transgenic Xenopus rods. Based on the experimental observations, we introduce a coarse-grained model of OS mechanical rigidity using elasticity theory, representing the axial OS banding explicitly via a spring-bead model. We calculate a bending stiffness of ∼105 nN⋅μm2, which is seven orders-of-magnitude larger than that of typical cilia and flagella. This bending stiffness has a quadratic relation to OS radius, so that thinner OS have lower fragility. Furthermore, we find that increasing the spatial frequency of axial OS banding decreases OS rigidity, reducing its fragility. Moreover, the model predicts a tendency for OS to break in bands with higher spring number density, analogous to the experimental observation that transgenic rods tended to break preferentially in bands of high fluorescence. We discuss how pathological alterations of disk membrane properties by mutant proteins may lead to increased OS rigidity and thus increased breakage, ultimately contributing to retinal degeneration. PMID:23442852

Absorption of a rigid frame porous layer with periodic circular inclusions backed by a periodic grating.

PubMed

Groby, J-P; Duclos, A; Dazel, O; Boeckx, L; Lauriks, W

2011-05-01

The acoustic properties of a periodic rigid frame porous layer with multiple irregularities in the rigid backing and embedded rigid circular inclusions are investigated theoretically and numerically. The theoretical representation of the sound field in the structure is obtained using a combination of multipole method that accounts for the periodic inclusions and multi-modal method that accounts for the multiple irregularities of the rigid backing. The theoretical model is validated against a finite element method. The predictions show that the acoustic response of this structure exhibits quasi-total, high absorption peaks at low frequencies which are below the frequency of the quarter-wavelength resonance typical for a flat homogeneous porous layer backed by a rigid plate. This result is explained by excitation of additional modes in the porous layer and by a complex interaction between various acoustic modes. These modes relate to the resonances associated with the presence of a profiled rigid backing and rigid inclusions in the porous layer.

Seamless integration of dose-response screening and flow chemistry: efficient generation of structure-activity relationship data of β-secretase (BACE1) inhibitors.

PubMed

Werner, Michael; Kuratli, Christoph; Martin, Rainer E; Hochstrasser, Remo; Wechsler, David; Enderle, Thilo; Alanine, Alexander I; Vogel, Horst

2014-02-03

Drug discovery is a multifaceted endeavor encompassing as its core element the generation of structure-activity relationship (SAR) data by repeated chemical synthesis and biological testing of tailored molecules. Herein, we report on the development of a flow-based biochemical assay and its seamless integration into a fully automated system comprising flow chemical synthesis, purification and in-line quantification of compound concentration. This novel synthesis-screening platform enables to obtain SAR data on b-secretase (BACE1) inhibitors at an unprecedented cycle time of only 1 h instead of several days. Full integration and automation of industrial processes have always led to productivity gains and cost reductions, and this work demonstrates how applying these concepts to SAR generation may lead to a more efficient drug discovery process. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Mechanically and optically reliable folding structure with a hyperelastic material for seamless foldable displays

NASA Astrophysics Data System (ADS)

Kwon, Hyuk-Jun; Shim, HongShik; Kim, Sunkook; Choi, Woong; Chun, Youngtea; Kee, InSeo; Lee, SangYoon

2011-04-01

We report a mechanically and optically robust folding structure to realize a foldable active matrix organic-light-emitting-diode (AMOLED) display without a visible crease at the junction. A nonlinear stress analysis, based on a finite element method, provided an optimized design. The folding-unfolding test on the structure exhibited negligible deterioration of the relative brightness at the junction of the individual panels up to 105 cycles at a folding radius of 1 mm, indicating highly reliable mechanical and optical tolerances. These results demonstrate the feasibility of seamless foldable AMOLED displays, with potentially important technical implications on fabricating large size flexible displays.

A seamless, high-resolution digital elevation model (DEM) of the north-central California coast

USGS Publications Warehouse

Foxgrover, Amy C.; Barnard, Patrick L.

2012-01-01

A seamless, 2-meter resolution digital elevation model (DEM) of the north-central California coast has been created from the most recent high-resolution bathymetric and topographic datasets available. The DEM extends approximately 150 kilometers along the California coastline, from Half Moon Bay north to Bodega Head. Coverage extends inland to an elevation of +20 meters and offshore to at least the 3 nautical mile limit of state waters. This report describes the procedures of DEM construction, details the input data sources, and provides the DEM for download in both ESRI Arc ASCII and GeoTIFF file formats with accompanying metadata.

Rigidity and retention of ceramic root canal posts.

PubMed

Purton, D G; Love, R M; Chandler, N P

2000-01-01

Ceramic root-canal posts offer potential advantages over other types with respect to aesthetics and biocompatibility. Any post must be sufficiently rigid and retentive to withstand functional forces. Ceraposts (1.2 mm coronal diameter, ceramic, tapering, smooth posts) and Paraposts (1.25 mm, stainless-steel, parallel, serrated posts) were tested for rigidity by means of a three-point bending test. To test retention in roots, ceramic posts were cemented using one of three protocols: (1) glass-ionomer cement, (2) silane coupling agent and resin cement, or (3) sandblasted post surface, silane coupling agent, and resin cement. Stainless-steel posts were cemented with resin. The tensile force required to dislodge the posts, following four weeks of storage in water, was recorded. Data were compared using Student's t-test and Mann-Whitney U analysis. Ceraposts were significantly more rigid than Paraposts (p < 0.001). Paraposts cemented with resin were significantly more strongly retained than Ceraposts following any cementation protocol (p < 0.001). Retention of the ceramic posts was significantly greater with a silane coupling agent and resin cement than with glass-ionomer cement (p < 0.001). Sandblasting the ceramic posts produced variable results and needs further investigation before it could be recommended.

Green waste cooking oil-based rigid polyurethane foam

NASA Astrophysics Data System (ADS)

Enderus, N. F.; Tahir, S. M.

2017-11-01

Polyurethane is a versatile polymer traditionally prepared using petroleum-based raw material. Petroleum, however, is a non-renewable material and polyurethane produced was found to be non-biodegradable. In quest for a more environmentally friendly alternative, wastecooking oil, a highly abundant domestic waste with easily derivatized structure, is a viable candidate to replace petroleum. In this study,an investigation to determine physical and chemical properties of rigid polyurethane (PU) foam from waste cooking oil (WCO) was carried out. WCO was first adsorbed by using coconut husk activated carbon adsorbent prior to be used for polyol synthesis. The purified WCO was then used to synthesize polyol via transesterification reaction to yield alcohol groups in the WCO chains structure. Finally, the WCO-based polyol was used to prepare rigid PU foam. The optimum formulation for PU formation was found to be 90 polyol: 60 glycerol: 54 water: 40 diethanolamine: 23 diisocyanate. The rigid PU foam has density of 208.4 kg/m3 with maximum compressive strength and capability to receive load at 0.03 MPa and 0.09 kN, respectively. WCO-based PU can potentially be used to replace petroleum-based PU as house construction materials such as insulation panels.

Real-Time and Seamless Monitoring of Ground-Level PM2.5 Using Satellite Remote Sensing

NASA Astrophysics Data System (ADS)

Li, Tongwen; Zhang, Chengyue; Shen, Huanfeng; Yuan, Qiangqiang; Zhang, Liangpei

2018-04-01

Satellite remote sensing has been reported to be a promising approach for the monitoring of atmospheric PM2.5. However, the satellite-based monitoring of ground-level PM2.5 is still challenging. First, the previously used polar-orbiting satellite observations, which can be usually acquired only once per day, are hard to monitor PM2.5 in real time. Second, many data gaps exist in satellitederived PM2.5 due to the cloud contamination. In this paper, the hourly geostationary satellite (i.e., Harawari-8) observations were adopted for the real-time monitoring of PM2.5 in a deep learning architecture. On this basis, the satellite-derived PM2.5 in conjunction with ground PM2.5 measurements are incorporated into a spatio-temporal fusion model to fill the data gaps. Using Wuhan Urban Agglomeration as an example, we have successfully derived the real-time and seamless PM2.5 distributions. The results demonstrate that Harawari-8 satellite-based deep learning model achieves a satisfactory performance (out-of-sample cross-validation R2 = 0.80, RMSE = 17.49 μg/m3) for the estimation of PM2.5. The missing data in satellite-derive PM2.5 are accurately recovered, with R2 between recoveries and ground measurements of 0.75. Overall, this study has inherently provided an effective strategy for the realtime and seamless monitoring of ground-level PM2.5.

The ISOMAX Magnetic Rigidity Spectrometer

NASA Astrophysics Data System (ADS)

Hams, Thomas

1999-08-01

The Isotope Magnet Experiment, (ISOMAX), is a balloon-borne superconducting magnetic spectrometer with a time-of-flight system and aerogel Cherenkov counters. Its purpose is to measure the isotopic composition of the light elements (3 < Z < 8) in the cosmic radiation. Particle mass is derived from a velocity vs. magnetic rigidity (momentum/charge) technique. The experiment had its first flight in August 1998. The precision magnetic spectrometer uses advanced drift-chamber tracking and a large, high-field, superconducting magnet. The drift-chamber system consists of three chambers with 24 layers of hexagonal drift cells (16 bending, 8 non-bending) and a vertical extent of 1.4 m. Pure CO2 gas is used. The magnet is a split-pair design with 79 cm diameter coils and a separation of 80 cm. During the 1998 flight, the central field was 0.8 T (60% of the full design field). Presented are results from flight data, for a range of incident particle Z, on the spatial resolution and efficiency of the tracking system, and on the maximum detectable rigidity (MDR) of the spectrometer. For in-flight data, spatial resolutions of 54 mm for Z=2 and 45 mm for Z=4 are obtained. An MDR of 970 GV/c is achieved for Z=2.

Understanding Behavioural Rigidity in Autism Spectrum Conditions: The Role of Intentional Control

ERIC Educational Resources Information Center

Poljac, Edita; Hoofs, Vincent; Princen, Myrthe M.; Poljac, Ervin

2017-01-01

Although behavioural rigidity belongs to the core symptoms of autism spectrum conditions, little is known about its underlying cognitive mechanisms. The current study investigated the role of intentional control mechanisms in behavioural rigidity in autism. Autistic individuals and their matched controls were instructed to repeatedly choose…

Cosmic Rays In The Magnetosphere, 2. Apparent Cut-off Rigidities and Coupling Functions

NASA Astrophysics Data System (ADS)

Dorman, L. I.; Danilova, O. A.; Iucci, N.; Parisi, M.; Ptitsyna, N. G.; Tyasto, M. I.; Villoresi, G.

We calculate the apparent cut-off rigidities along the survey Italy-Antarctica-Italy** on the basis of results of Danilova et al. (2001) on trajectory calculations for inclined cut- off rigidities at eight azimuths (through 45?) and five zeniths angles (through 15?) along the survey. For calculations of apparent cut-off rigidities we use also the infor- mation on integral multiplicities of secondary neutrons in dependence of zenith angle of incident primary cosmic ray particles, as theoretically computed. This information is based on the theoretical calculations of meson-nuclear cascades for primary protons with different rigidities arriving to the EarthSs atmosphere at different zenith angles (Dorman and Pakhomov, 1979). These results have been checked and normalized by using coupling functions obtained in the same survey [Dorman et al. (2000)]. The determined apparent cut-off rigidities have been compared with results obtained by Clem et al. (1997) and with those used by Dorman et al. (2000) computed by using vertical cut-off rigidities, for trajectories especially calculated for the survey. On the basis of the apparent cut-off rigidities along the latitude survey, the coupling functions for neutron monitor and bare neutron counters found by Dorman et al. (2000) are now determined more accurately. **Survey realized with logistic and financial support of the Italian Antarctic Program (PNRA) and with the co-operation of IFSI-CNR. REFERENCES: Clem, J.M., et al. J. Geophys. Res., 102, 26,919 (1997). Danilova, O.A., et al., Latitude survey in December 1996-March 1997, 1. Cut-off rigidities for different azimuth and zenith angles, Paper ST13, This issue (2001) Dorman L.I. and Pakhomov N.I., "The dependence of the integral generation multiplicity of neutron component at various depths in the atmosphere on zenith angle on primary particle in- cidence". Proc. 16-th ICRC, Kyoto, 4, 416-420 (1979) Dorman, L.I., et al., J. Geophys. Res. 105 , 21,047 (2000).

Rigid spine reinforced polymer microelectrode array probe and method of fabrication

DOEpatents

Tabada, Phillipe; Pannu, Satinderpall S

2014-05-27

A rigid spine-reinforced microelectrode array probe and fabrication method. The probe includes a flexible elongated probe body with conductive lines enclosed within a polymeric material. The conductive lines connect microelectrodes found near an insertion end of the probe to respective leads at a connector end of the probe. The probe also includes a rigid spine, such as made from titanium, fixedly attached to the probe body to structurally reinforce the probe body and enable the typically flexible probe body to penetrate and be inserted into tissue, such as neural tissue. By attaching or otherwise fabricating the rigid spine to connect to only an insertion section of the probe body, an integrally connected cable section of the probe body may remain flexible.

Electromagnetic Scattering by Fully Ordered and Quasi-Random Rigid Particulate Samples

NASA Technical Reports Server (NTRS)

Mishchenko, Michael I.; Dlugach, Janna M.; Mackowski, Daniel W.

2016-01-01

In this paper we have analyzed circumstances under which a rigid particulate sample can behave optically as a true discrete random medium consisting of particles randomly moving relative to each other during measurement. To this end, we applied the numerically exact superposition T-matrix method to model far-field scattering characteristics of fully ordered and quasi-randomly arranged rigid multiparticle groups in fixed and random orientations. We have shown that, in and of itself, averaging optical observables over movements of a rigid sample as a whole is insufficient unless it is combined with a quasi-random arrangement of the constituent particles in the sample. Otherwise, certain scattering effects typical of discrete random media (including some manifestations of coherent backscattering) may not be accurately replicated.

Parameter Optimization of Pseudo-Rigid-Body Models of MRI-Actuated Catheters

PubMed Central

Greigarn, Tipakorn; Liu, Taoming; Çavuşoğlu, M. Cenk

2016-01-01

Simulation and control of a system containing compliant mechanisms such as cardiac catheters often incur high computational costs. One way to reduce the costs is to approximate the mechanisms with Pseudo-Rigid-Body Models (PRBMs). A PRBM generally consists of rigid links connected by spring-loaded revolute joints. The lengths of the rigid links and the stiffnesses of the springs are usually chosen to minimize the tip deflection differences between the PRBM and the compliant mechanism. In most applications, only the relationship between end load and tip deflection is considered. This is obviously not applicable for MRI-actuated catheters which is actuated by the coils attached to the body. This paper generalizes PRBM parameter optimization to include loading and reference points along the body. PMID:28261009

PEEX Modelling Platform for Seamless Environmental Prediction

NASA Astrophysics Data System (ADS)

Baklanov, Alexander; Mahura, Alexander; Arnold, Stephen; Makkonen, Risto; Petäjä, Tuukka; Kerminen, Veli-Matti; Lappalainen, Hanna K.; Ezau, Igor; Nuterman, Roman; Zhang, Wen; Penenko, Alexey; Gordov, Evgeny; Zilitinkevich, Sergej; Kulmala, Markku

2017-04-01

The Pan-Eurasian EXperiment (PEEX) is a multidisciplinary, multi-scale research programme stared in 2012 and aimed at resolving the major uncertainties in Earth System Science and global sustainability issues concerning the Arctic and boreal Northern Eurasian regions and in China. Such challenges include climate change, air quality, biodiversity loss, chemicalization, food supply, and the use of natural resources by mining, industry, energy production and transport. The research infrastructure introduces the current state of the art modeling platform and observation systems in the Pan-Eurasian region and presents the future baselines for the coherent and coordinated research infrastructures in the PEEX domain. The PEEX modeling Platform is characterized by a complex seamless integrated Earth System Modeling (ESM) approach, in combination with specific models of different processes and elements of the system, acting on different temporal and spatial scales. The ensemble approach is taken to the integration of modeling results from different models, participants and countries. PEEX utilizes the full potential of a hierarchy of models: scenario analysis, inverse modeling, and modeling based on measurement needs and processes. The models are validated and constrained by available in-situ and remote sensing data of various spatial and temporal scales using data assimilation and top-down modeling. The analyses of the anticipated large volumes of data produced by available models and sensors will be supported by a dedicated virtual research environment developed for these purposes.

Mitral stenosis due to pannus overgrowth after rigid ring annuloplasty.

PubMed

Oda, Takeshi; Kato, Seiya; Tayama, Eiki; Fukunaga, Shuji; Akashi, Hidetoshi; Aoyagi, Shigeaki

2010-03-01

Although mitral stenosis (MS) due to pannus overgrowth after mitral valve repair for rheumatic mitral regurgitation (MR) is not uncommon, it is extremely rare in relation to non-rheumatic mitral regurgitation. Whilst it has been suggested that the rigid annuloplasty ring induces pannus overgrowth in the same manner as the flexible ring, to date only in cases using the flexible ring has pannus formation been confirmed by a pathological examination after redo surgery. The case is described of a woman who had undergone mitral valve repair using a 28 mm rigid ring three years previously because of non-rheumatic MR, and subsequently suffered from MS due to pannus formation over the annuloplasty ring. To the present authors' knowledge, this is the first report of MS due to pannus formation after mitral valve repair using a rigid annuloplasty ring to treat non-rheumatic MR documented at reoperation.

Authoritarianism, cognitive rigidity, and the processing of ambiguous visual information.

PubMed

Duncan, Lauren E; Peterson, Bill E

2014-01-01

Intolerance of ambiguity and cognitive rigidity are unifying aspects of authoritarianism as defined by Adorno, Frenkel-Brunswik, Levinson, and Sanford (1982/1950), who hypothesized that authoritarians view the world in absolute terms (e.g., good or evil). Past studies have documented the relationship between authoritarianism and intolerance of ambiguity and rigidity. Frenkel-Brunswik (1949) hypothesized that this desire for absolutism was rooted in perceptual processes. We present a study with three samples that directly tests the relationship between right wing authoritarianism (RWA) and the processing of ideologically neutral but ambiguous visual stimuli. As hypothesized, in all three samples we found that RWA was related to the slower processing of visual information that required participants to recategorize objects. In a fourth sample, RWA was unrelated to speed of processing visual information that did not require recategorization. Overall, results suggest a relationship between RWA and rigidity in categorization.

In-Flight Stability Analysis of the X-48B Aircraft

NASA Technical Reports Server (NTRS)

Regan, Christopher D.

2008-01-01

This report presents the system description, methods, and sample results of the in-flight stability analysis for the X-48B, Blended Wing Body Low-Speed Vehicle. The X-48B vehicle is a dynamically scaled, remotely piloted vehicle developed to investigate the low-speed control characteristics of a full-scale blended wing body. Initial envelope clearance was conducted by analyzing the stability margin estimation resulting from the rigid aircraft response during flight and comparing it to simulation data. Short duration multisine signals were commanded onboard to simultaneously excite the primary rigid body axes. In-flight stability analysis has proven to be a critical component of the initial envelope expansion.

Learned Non-Rigid Object Motion is a View-Invariant Cue to Recognizing Novel Objects

PubMed Central

Chuang, Lewis L.; Vuong, Quoc C.; Bülthoff, Heinrich H.

2012-01-01

There is evidence that observers use learned object motion to recognize objects. For instance, studies have shown that reversing the learned direction in which a rigid object rotated in depth impaired recognition accuracy. This motion reversal can be achieved by playing animation sequences of moving objects in reverse frame order. In the current study, we used this sequence-reversal manipulation to investigate whether observers encode the motion of dynamic objects in visual memory, and whether such dynamic representations are encoded in a way that is dependent on the viewing conditions. Participants first learned dynamic novel objects, presented as animation sequences. Following learning, they were then tested on their ability to recognize these learned objects when their animation sequence was shown in the same sequence order as during learning or in the reverse sequence order. In Experiment 1, we found that non-rigid motion contributed to recognition performance; that is, sequence-reversal decreased sensitivity across different tasks. In subsequent experiments, we tested the recognition of non-rigidly deforming (Experiment 2) and rigidly rotating (Experiment 3) objects across novel viewpoints. Recognition performance was affected by viewpoint changes for both experiments. Learned non-rigid motion continued to contribute to recognition performance and this benefit was the same across all viewpoint changes. By comparison, learned rigid motion did not contribute to recognition performance. These results suggest that non-rigid motion provides a source of information for recognizing dynamic objects, which is not affected by changes to viewpoint. PMID:22661939

Settling dynamics of asymmetric rigid fibers

Treesearch

E.J. Tozzi; C Tim Scott; David Vahey; D.J. Klingenberg

2011-01-01

The three-dimensional motion of asymmetric rigid fibers settling under gravity in a quiescent fluid was experimentally measured using a pair of cameras located on a movable platform. The particle motion typically consisted of an initial transient after which the particle approached a steady rate of rotation about an axis parallel to the acceleration of gravity, with...

Stretchy Proteins on Stretchy Substrates: The Important Elements of Integrin-Mediated Rigidity Sensing

PubMed Central

Moore, Simon W.; Roca-Cusachs, Pere; Sheetz, Michael P.

2013-01-01

Matrix and tissue rigidity guides many cellular processes, including the differentiation of stem cells and the migration of cells in health and disease. Cells actively and transiently test rigidity using mechanisms limited by inherent physical parameters that include the strength of extracellular attachments, the pulling capacity on these attachments, and the sensitivity of the mechanotransduction system. Here we focus on rigidity sensing mediated through the integrin family of extracellular matrix receptors and linked proteins, and discuss the evidence supporting these proteins as mechanosensors. PMID:20708583

Calculations of critical micelle concentration by dissipative particle dynamics simulations: the role of chain rigidity.

PubMed

Lee, Ming-Tsung; Vishnyakov, Aleksey; Neimark, Alexander V

2013-09-05

Micelle formation in surfactant solutions is a self-assembly process governed by complex interplay of solvent-mediated interactions between hydrophilic and hydrophobic groups, which are commonly called heads and tails. However, the head-tail repulsion is not the only factor affecting the micelle formation. For the first time, we present a systematic study of the effect of chain rigidity on critical micelle concentration and micelle size, which is performed with the dissipative particle dynamics simulation method. Rigidity of the coarse-grained surfactant molecule was controlled by the harmonic bonds set between the second-neighbor beads. Compared to flexible molecules with the nearest-neighbor bonds being the only type of bonded interactions, rigid molecules exhibited a lower critical micelle concentration and formed larger and better-defined micelles. By varying the strength of head-tail repulsion and the chain rigidity, we constructed two-dimensional diagrams presenting how the critical micelle concentration and aggregation number depend on these parameters. We found that the solutions of flexible and rigid molecules that exhibited approximately the same critical micelle concentration could differ substantially in the micelle size and shape depending on the chain rigidity. With the increase of surfactant concentration, primary micelles of more rigid molecules were found less keen to agglomeration and formation of nonspherical aggregates characteristic of flexible molecules.

Matching multiple rigid domain decompositions of proteins

PubMed Central

Flynn, Emily; Streinu, Ileana

2017-01-01

We describe efficient methods for consistently coloring and visualizing collections of rigid cluster decompositions obtained from variations of a protein structure, and lay the foundation for more complex setups that may involve different computational and experimental methods. The focus here is on three biological applications: the conceptually simpler problems of visualizing results of dilution and mutation analyses, and the more complex task of matching decompositions of multiple NMR models of the same protein. Implemented into the KINARI web server application, the improved visualization techniques give useful information about protein folding cores, help examining the effect of mutations on protein flexibility and function, and provide insights into the structural motions of PDB proteins solved with solution NMR. These tools have been developed with the goal of improving and validating rigidity analysis as a credible coarse-grained model capturing essential information about a protein’s slow motions near the native state. PMID:28141528

Pediatric mandibular fractures treated by rigid internal fixation.

PubMed

Wong, G B

1993-09-01

Mandibular fractures in the pediatric patient population are relatively uncommon. These patients present with their own unique treatment requirements. Most fractures have been treated conservatively by dental splints. Closed reduction techniques with maxillomandibular fixation (MMF) in very young children can pose several concerns, including cooperation, compliance and adequate nutritional intake. Rigid internal fixation of unstable mandibular fractures using miniplates and screws circumvents the need for MMF and allows immediate jaw mobilization. At major pediatric trauma institutions, there has been an increasing trend toward the use of this treatment when open reduction is necessary. This article presents a report of a five-year-old child who presented with bilateral mandibular fractures and was treated by rigid internal fixation and immediate mandibular mobilization.

Stresses in Circular Plates with Rigid Elements

NASA Astrophysics Data System (ADS)

Velikanov, N. L.; Koryagin, S. I.; Sharkov, O. V.

2018-05-01

Calculations of residual stress fields are carried out by numerical and static methods, using the flat cross-section hypothesis. The failure of metal when exposed to residual stresses is, in most cases, brittle. The presence in the engineering structures of rigid elements often leads to the crack initiation and structure failure. This is due to the fact that rigid elements under the influence of external stresses are stress concentrators. In addition, if these elements are fixed by welding, the residual welding stresses can lead to an increase in stress concentration and, ultimately, to failure. The development of design schemes for such structures is a very urgent task for complex technical systems. To determine the stresses in a circular plate with a welded circular rigid insert under the influence of an external load, one can use the solution of the plane stress problem for annular plates in polar coordinates. The polar coordinates of the points are the polar radius and the polar angle, and the stress state is determined by normal radial stresses, tangential and shearing stresses. The use of the above mentioned design schemes, formulas, will allow more accurate determination of residual stresses in annular welded structures. This will help to establish the most likely directions of failure and take measures at the stages of designing, manufacturing and repairing engineering structures to prevent these failures. However, it must be taken into account that the external load, the presence of insulation can lead to a change in the residual stress field.

An Interface for Specifying Rigid-Body Motions for CFD Applications

NASA Technical Reports Server (NTRS)

Murman, Scott M.; Chan, William; Aftosmis, Michael; Meakin, Robert L.; Kwak, Dochan (Technical Monitor)

2003-01-01

An interface for specifying rigid-body motions for CFD applications is presented. This interface provides a means of describing a component hierarchy in a geometric configuration, as well as the motion (prescribed or six-degree-of-freedom) associated with any component. The interface consists of a general set of datatypes, along with rules for their interaction, and is designed to be flexible in order to evolve as future needs dictate. The specification is currently implemented with an XML file format which is portable across platforms and applications. The motion specification is capable of describing general rigid body motions, and eliminates the need to write and compile new code within the application software for each dynamic configuration, allowing client software to automate dynamic simulations. The interface is integrated with a GUI tool which allows rigid body motions to be prescribed and verified interactively, promoting access to non-expert users. Illustrative examples, as well as the raw XML source of the file specifications, are included.

Heat Transfer Measurement and Modeling in Rigid High-Temperature Reusable Surface Insulation Tiles

NASA Technical Reports Server (NTRS)

Daryabeigi, Kamran; Knutson, Jeffrey R.; Cunnington, George R.

2011-01-01

Heat transfer in rigid reusable surface insulations was investigated. Steady-state thermal conductivity measurements in a vacuum were used to determine the combined contribution of radiation and solid conduction components of heat transfer. Thermal conductivity measurements at higher pressures were then used to estimate the effective insulation characteristic length for gas conduction modeling. The thermal conductivity of the insulation can then be estimated at any temperature and pressure in any gaseous media. The methodology was validated by comparing estimated thermal conductivities with published data on a rigid high-temperature silica reusable surface insulation tile. The methodology was also applied to the alumina enhanced thermal barrier tiles. Thermal contact resistance for thermal conductivity measurements on rigid tiles was also investigated. A technique was developed to effectively eliminate thermal contact resistance on the rigid tile s cold-side surface for the thermal conductivity measurements.

Non-rigid registration between 3D ultrasound and CT images of the liver based on intensity and gradient information

NASA Astrophysics Data System (ADS)

Lee, Duhgoon; Nam, Woo Hyun; Lee, Jae Young; Ra, Jong Beom

2011-01-01

In order to utilize both ultrasound (US) and computed tomography (CT) images of the liver concurrently for medical applications such as diagnosis and image-guided intervention, non-rigid registration between these two types of images is an essential step, as local deformation between US and CT images exists due to the different respiratory phases involved and due to the probe pressure that occurs in US imaging. This paper introduces a voxel-based non-rigid registration algorithm between the 3D B-mode US and CT images of the liver. In the proposed algorithm, to improve the registration accuracy, we utilize the surface information of the liver and gallbladder in addition to the information of the vessels inside the liver. For an effective correlation between US and CT images, we treat those anatomical regions separately according to their characteristics in US and CT images. Based on a novel objective function using a 3D joint histogram of the intensity and gradient information, vessel-based non-rigid registration is followed by surface-based non-rigid registration in sequence, which improves the registration accuracy. The proposed algorithm is tested for ten clinical datasets and quantitative evaluations are conducted. Experimental results show that the registration error between anatomical features of US and CT images is less than 2 mm on average, even with local deformation due to different respiratory phases and probe pressure. In addition, the lesion registration error is less than 3 mm on average with a maximum of 4.5 mm that is considered acceptable for clinical applications.

32 CFR 861.1 - References.

Code of Federal Regulations, 2010 CFR

2010-07-01

...: (a) 10 U.S.C. 2640, Charter Air Transportation of Members of the Armed Forces. (b) Department of Defense Directive 4500.53, Department of Defense Commercial Air Transportation Quality and Safety Review... Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT DEPARTMENT OF DEFENSE COMMERCIAL AIR...

Phosphorescence and Energy Transfer in Rigid Solutions.

ERIC Educational Resources Information Center

Enciso, E.; Cabello, A.

1980-01-01

Describes an experiment which illustrates the general aspects of intermolecular energy transfer between triplet states in rigid solutions of organic compounds solved in an ethanol-ether mixture. Measurements of quenching and energy transfer processes are made using the chemicals of benzophenone and naphthalene. (CS)

JPSS-1 Data and the EOSDIS System: It's seamless

NASA Astrophysics Data System (ADS)

Hall, A.; Behnke, J.; Ho, E.

2017-12-01

The continuity of climate and environmental data is the key to the NASA Earth science program to develop a scientific understanding of Earth's system and its response to changes. NASA has made a long-term investment in processing, archiving and distributing Earth science data through the Earth Observing System (EOS) Data and Information System (EOSDIS). The use of the EOSDIS infrastructure and services provides seamless integration of Suomi National Polar-Orbiting Partnership (SNPP) and future Joint Polar Satellite System (JPSS-1) products as it does for the entire NASA Earth Science data collection. This continuity of measurements from all the missions is supported by the use of common data structures and standards in the generation of products and the subsequent services, tools and access to those products. Similar to EOS missions, 5 Science Investigator-led Processing Systems (SIPS) were established for SNPP: Land, Ocean, Atmosphere, Ozone, and Sounder along with NASA's Clouds and the Earth's Radiant Energy System and Ozone Mapper/Profiler Suite Limb systems now produce the NASA SNPP standard Level 1, Level 2, and Level 3 products developed by the NASA science teams.

Multimodality Non-Rigid Image Registration for Planning, Targeting and Monitoring during CT-guided Percutaneous Liver Tumor Cryoablation

PubMed Central

Elhawary, Haytham; Oguro, Sota; Tuncali, Kemal; Morrison, Paul R.; Tatli, Servet; Shyn, Paul B.; Silverman, Stuart G.; Hata, Nobuhiko

2010-01-01

Rationale and Objectives To develop non-rigid image registration between pre-procedure contrast enhanced MR images and intra-procedure unenhanced CT images, to enhance tumor visualization and localization during CT-guided liver tumor cryoablation procedures. Materials and Methods After IRB approval, a non-rigid registration (NRR) technique was evaluated with different pre-processing steps and algorithm parameters and compared to a standard rigid registration (RR) approach. The Dice Similarity Coefficient (DSC), Target Registration Error (TRE), 95% Hausdorff distance (HD) and total registration time (minutes) were compared using a two-sided Student’s t-test. The entire registration method was then applied during five CT-guided liver cryoablation cases with the intra-procedural CT data transmitted directly from the CT scanner, with both accuracy and registration time evaluated. Results Selected optimal parameters for registration were section thickness of 5mm, cropping the field of view to 66% of its original size, manual segmentation of the liver, B-spline control grid of 5×5×5 and spatial sampling of 50,000 pixels. Mean 95% HD of 3.3mm (2.5x improvement compared to RR, p<0.05); mean DSC metric of 0.97 (13% increase); and mean TRE of 4.1mm (2.7x reduction) were measured. During the cryoablation procedure registration between the pre-procedure MR and the planning intra-procedure CT took a mean time of 10.6 minutes, the MR to targeting CT image took 4 minutes and MR to monitoring CT took 4.3 minutes. Mean registration accuracy was under 3.4mm. Conclusion Non-rigid registration allowed improved visualization of the tumor during interventional planning, targeting and evaluation of tumor coverage by the ice ball. Future work is focused on reducing segmentation time to make the method more clinically acceptable. PMID:20817574

Multiscale weighted colored graphs for protein flexibility and rigidity analysis

NASA Astrophysics Data System (ADS)

Bramer, David; Wei, Guo-Wei

2018-02-01

Protein structural fluctuation, measured by Debye-Waller factors or B-factors, is known to correlate to protein flexibility and function. A variety of methods has been developed for protein Debye-Waller factor prediction and related applications to domain separation, docking pose ranking, entropy calculation, hinge detection, stability analysis, etc. Nevertheless, none of the current methodologies are able to deliver an accuracy of 0.7 in terms of the Pearson correlation coefficients averaged over a large set of proteins. In this work, we introduce a paradigm-shifting geometric graph model, multiscale weighted colored graph (MWCG), to provide a new generation of computational algorithms to significantly change the current status of protein structural fluctuation analysis. Our MWCG model divides a protein graph into multiple subgraphs based on interaction types between graph nodes and represents the protein rigidity by generalized centralities of subgraphs. MWCGs not only predict the B-factors of protein residues but also accurately analyze the flexibility of all atoms in a protein. The MWCG model is validated over a number of protein test sets and compared with many standard methods. An extensive numerical study indicates that the proposed MWCG offers an accuracy of over 0.8 and thus provides perhaps the first reliable method for estimating protein flexibility and B-factors. It also simultaneously predicts all-atom flexibility in a molecule.

A rigidity transition and glassy dynamics in a model for confluent 3D tissues

NASA Astrophysics Data System (ADS)

Merkel, Matthias; Manning, M. Lisa

The origin of rigidity in disordered materials is an outstanding open problem in statistical physics. Recently, a new type of rigidity transition was discovered in a family of models for 2D biological tissues, but the mechanisms responsible for rigidity remain unclear. This is not just a statistical physics problem, but also relevant for embryonic development, cancer growth, and wound healing. To gain insight into this rigidity transition and make new predictions about biological bulk tissues, we have developed a fully 3D self-propelled Voronoi (SPV) model. The model takes into account shape, elasticity, and self-propelled motion of the individual cells. We find that in the absence of self-propulsion, this model exhibits a rigidity transition that is controlled by a dimensionless model parameter describing the preferred cell shape, with an accompanying structural order parameter. In the presence of self-propulsion, the rigidity transition appears as a glass-like transition featuring caging and aging effects. Given the similarities between this transition and jamming in particulate solids, it is natural to ask if the two transitions are related. By comparing statistics of Voronoi geometries, we show the transitions are surprisingly close but demonstrably distinct. Furthermore, an index theorem used to identify topologically protected mechanical modes in jammed systems can be extended to these vertex-type models. In our model, residual stresses govern the transition and enter the index theorem in a different way compared to jammed particles, suggesting the origin of rigidity may be different between the two.

Changes in E-cadherin rigidity sensing regulate cell adhesion.

PubMed

Collins, Caitlin; Denisin, Aleksandra K; Pruitt, Beth L; Nelson, W James

2017-07-18

Mechanical cues are sensed and transduced by cell adhesion complexes to regulate diverse cell behaviors. Extracellular matrix (ECM) rigidity sensing by integrin adhesions has been well studied, but rigidity sensing by cadherins during cell adhesion is largely unexplored. Using mechanically tunable polyacrylamide (PA) gels functionalized with the extracellular domain of E-cadherin (Ecad-Fc), we showed that E-cadherin-dependent epithelial cell adhesion was sensitive to changes in PA gel elastic modulus that produced striking differences in cell morphology, actin organization, and membrane dynamics. Traction force microscopy (TFM) revealed that cells produced the greatest tractions at the cell periphery, where distinct types of actin-based membrane protrusions formed. Cells responded to substrate rigidity by reorganizing the distribution and size of high-traction-stress regions at the cell periphery. Differences in adhesion and protrusion dynamics were mediated by balancing the activities of specific signaling molecules. Cell adhesion to a 30-kPa Ecad-Fc PA gel required Cdc42- and formin-dependent filopodia formation, whereas adhesion to a 60-kPa Ecad-Fc PA gel induced Arp2/3-dependent lamellipodial protrusions. A quantitative 3D cell-cell adhesion assay and live cell imaging of cell-cell contact formation revealed that inhibition of Cdc42, formin, and Arp2/3 activities blocked the initiation, but not the maintenance of established cell-cell adhesions. These results indicate that the same signaling molecules activated by E-cadherin rigidity sensing on PA gels contribute to actin organization and membrane dynamics during cell-cell adhesion. We hypothesize that a transition in the stiffness of E-cadherin homotypic interactions regulates actin and membrane dynamics during initial stages of cell-cell adhesion.

Changes in E-cadherin rigidity sensing regulate cell adhesion

PubMed Central

Collins, Caitlin; Pruitt, Beth L.; Nelson, W. James

2017-01-01

Mechanical cues are sensed and transduced by cell adhesion complexes to regulate diverse cell behaviors. Extracellular matrix (ECM) rigidity sensing by integrin adhesions has been well studied, but rigidity sensing by cadherins during cell adhesion is largely unexplored. Using mechanically tunable polyacrylamide (PA) gels functionalized with the extracellular domain of E-cadherin (Ecad-Fc), we showed that E-cadherin–dependent epithelial cell adhesion was sensitive to changes in PA gel elastic modulus that produced striking differences in cell morphology, actin organization, and membrane dynamics. Traction force microscopy (TFM) revealed that cells produced the greatest tractions at the cell periphery, where distinct types of actin-based membrane protrusions formed. Cells responded to substrate rigidity by reorganizing the distribution and size of high-traction-stress regions at the cell periphery. Differences in adhesion and protrusion dynamics were mediated by balancing the activities of specific signaling molecules. Cell adhesion to a 30-kPa Ecad-Fc PA gel required Cdc42- and formin-dependent filopodia formation, whereas adhesion to a 60-kPa Ecad-Fc PA gel induced Arp2/3-dependent lamellipodial protrusions. A quantitative 3D cell–cell adhesion assay and live cell imaging of cell–cell contact formation revealed that inhibition of Cdc42, formin, and Arp2/3 activities blocked the initiation, but not the maintenance of established cell–cell adhesions. These results indicate that the same signaling molecules activated by E-cadherin rigidity sensing on PA gels contribute to actin organization and membrane dynamics during cell–cell adhesion. We hypothesize that a transition in the stiffness of E-cadherin homotypic interactions regulates actin and membrane dynamics during initial stages of cell–cell adhesion. PMID:28674019

Water vapor permeability of the rigid-shelled gecko egg.

PubMed

Andrews, Robin M

2012-07-01

The vast majority of squamate reptiles (lizards and snakes) produce parchment-shelled eggs that absorb water during incubation, and thus increase in mass, volume, and surface area. In contrast, females from a single monophyletic lineage of gekkotan lizards produce rigid-shelled eggs. These eggs are functionally comparable to those of birds, that is, at oviposition, eggs contain all the water needed for development, and their mass decreases during incubation via the diffusion of water vapor through the shell. I determined patterns of water loss and shell permeability to water vapor from oviposition to hatching for the rigid-shelled eggs of the gekkonid Chrondrodactylus turneri and compared permeability of C. turneri eggs to those of birds and other squamates. Chrondrodactylus turneri eggs incubated at 28.5°C and 40% relative humidity (RH) decreased in mass by 14% over the course of a 68-day incubation period. The rate of water loss varied during incubation; egg mass decreased rapidly during the first 8 days of incubation, declined at a low constant rate during the next 35 days, and then decreased rapidly during the final 25 days of incubation. Overall permeability was 0.17 mg/day/kPa/cm(2) . Percent water loss of rigid-shelled gecko eggs during incubation is similar to that exhibited by birds, but water vapor permeability is about one-third that of bird eggs and several orders of magnitude lower than that of parchment-shelled squamate eggs. In general, the water economy of their eggs may be associated with the adaptive radiation of the rigid-shelled sphaerodactylid, phyllodactylid, and gekkonid geckos. © 2012 WILEY PERIODICALS, INC.

A relativistic generalisation of rigid motions

NASA Astrophysics Data System (ADS)

Llosa, J.; Molina, A.; Soler, D.

2012-07-01

A weaker substitute for the too restrictive class of Born-rigid motions is proposed, which we call radar-holonomic motions. The definition is expressed as a set of differential equations. Integrability conditions and Cauchy problem are studied. We finally obtain an example of a radar-holonomic congruence containing a given worldline with a given value of the rotation on this line.

Rigid Residue Scan Simulations Systematically Reveal Residue Entropic Roles in Protein Allostery

PubMed Central

Liu, Jin

2016-01-01

Intra-protein information is transmitted over distances via allosteric processes. This ubiquitous protein process allows for protein function changes due to ligand binding events. Understanding protein allostery is essential to understanding protein functions. In this study, allostery in the second PDZ domain (PDZ2) in the human PTP1E protein is examined as model system to advance a recently developed rigid residue scan method combining with configurational entropy calculation and principal component analysis. The contributions from individual residues to whole-protein dynamics and allostery were systematically assessed via rigid body simulations of both unbound and ligand-bound states of the protein. The entropic contributions of individual residues to whole-protein dynamics were evaluated based on covariance-based correlation analysis of all simulations. The changes of overall protein entropy when individual residues being held rigid support that the rigidity/flexibility equilibrium in protein structure is governed by the La Châtelier’s principle of chemical equilibrium. Key residues of PDZ2 allostery were identified with good agreement with NMR studies of the same protein bound to the same peptide. On the other hand, the change of entropic contribution from each residue upon perturbation revealed intrinsic differences among all the residues. The quasi-harmonic and principal component analyses of simulations without rigid residue perturbation showed a coherent allosteric mode from unbound and bound states, respectively. The projection of simulations with rigid residue perturbation onto coherent allosteric modes demonstrated the intrinsic shifting of ensemble distributions supporting the population-shift theory of protein allostery. Overall, the study presented here provides a robust and systematic approach to estimate the contribution of individual residue internal motion to overall protein dynamics and allostery. PMID:27115535

Virtual rigid body: a new optical tracking paradigm in image-guided interventions

NASA Astrophysics Data System (ADS)

Cheng, Alexis; Lee, David S.; Deshmukh, Nishikant; Boctor, Emad M.

2015-03-01

Tracking technology is often necessary for image-guided surgical interventions. Optical tracking is one the options, but it suffers from line of sight and workspace limitations. Optical tracking is accomplished by attaching a rigid body marker, having a pattern for pose detection, onto a tool or device. A larger rigid body results in more accurate tracking, but at the same time large size limits its usage in a crowded surgical workspace. This work presents a prototype of a novel optical tracking method using a virtual rigid body (VRB). We define the VRB as a 3D rigid body marker in the form of pattern on a surface generated from a light source. Its pose can be recovered by observing the projected pattern with a stereo-camera system. The rigid body's size is no longer physically limited as we can manufacture small size light sources. Conventional optical tracking also requires line of sight to the rigid body. VRB overcomes these limitations by detecting a pattern projected onto the surface. We can project the pattern onto a region of interest, allowing the pattern to always be in the view of the optical tracker. This helps to decrease the occurrence of occlusions. This manuscript describes the method and results compared with conventional optical tracking in an experiment setup using known motions. The experiments are done using an optical tracker and a linear-stage, resulting in targeting errors of 0.38mm+/-0.28mm with our method compared to 0.23mm+/-0.22mm with conventional optical markers. Another experiment that replaced the linear stage with a robot arm resulted in rotational errors of 0.50+/-0.31° and 2.68+/-2.20° and the translation errors of 0.18+/-0.10 mm and 0.03+/-0.02 mm respectively.

Acoustic radiation efficiency of a periodically corrugated rigid piston

NASA Astrophysics Data System (ADS)

Estrada, Héctor; Uris, Antonio; Meseguer, Francisco

2012-09-01

The radiation of sound by a periodically corrugated rigid piston is explored using theoretical and numerical approaches and compared with the radiation of flat rigid piston. The depth and the period of the corrugation are considered to be comparable with the wavelength in the surrounding fluid. Radiation enhancement is predicted due to cavity resonances and coherent diffraction. In addition, broad regions of low radiation efficiency are observed. Both effects could have an impact in acoustic transducers technology, either to increase the piston radiated power or to create a source of evanescent acoustic waves. The possibilities offered by this strategy in the nonlinear acoustic regime are also briefly discussed.

The value of shear wave elastography in the quantification of corpus cavernosum penis rigidity and its alteration with age.

PubMed

Inci, Ercan; Turkay, Rustu; Nalbant, Mustafa Orhan; Yenice, Mustafa Gurkan; Tugcu, Volkan

2017-04-01

The goal of this study was to measure corpus cavernosum (CC) penis rigidity with shear wave elastography (SWE) in healthy volunteers and to evaluate the change of rigidity with age. SWE was performed in 60 healthy volunteers (age range 20-71, mean 47±12,83 years). Volunteers were divided into 2 groups by age (Group 1 age <50, group 2 age ≥50). We assessed SWE in 3 parts of penis (proximal, middle and glans penis) on both sides of CC. All values of SWE (in kilo Pascal) were noted along with volunteers' ages. The measurements were done both with transverse (T) and longitudinal (L) sections. We compared all SW values of penis parts and their alterations with age. The shear wave elastography values of CC penis increased with increasing age (p<0,01). There was no significant difference between both sides of CC penis (p<0,05). We calculated no significant difference between T and L sections of all parts of penis (p<0,05). SWE can provide noninvasive quantitative data of CC penis rigidity and its alteration with age. These data may create a new approach in the evaluation process and treatment options for penile pathologies. Copyright © 2017 Elsevier B.V. All rights reserved.

Analysis of electric vehicle extended range misalignment based on rigid-flexible dynamics

NASA Astrophysics Data System (ADS)

Xu, Xiaowei; Lv, Mingliang; Chen, Zibo; Ji, Wei; Gao, Ruiceng

2017-04-01

The safety of the extended range electric vehicle is seriously affected by the misalignment fault. Therefore, this paper analyzed the electric vehicle extended range misalignment based on rigid-flexible dynamics. Through comprehensively applied the hybrid modeling of rigid-flexible and the method of fault diagnosis of machinery and equipment comprehensively, it established a extender hybrid rigid flexible mechanical model by means of the software ADAMS and ANSYS. By setting the relevant parameters to simulate the misalignment of shafting, the failure phenomenon, the spectrum analysis and the evolution rules were analyzed. It concluded that 0.5th and 1 harmonics are considered as the characteristic parameters of misalignment diagnostics for electric vehicle extended range.

75 FR 26716 - Seamless Refined Copper Pipe and Tube from the People's Republic of China: Preliminary...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-12

...The Department of Commerce (the ``Department'') has preliminarily determined that seamless refined copper pipe and tube (``copper pipe and tube'') from the People's Republic of China (``PRC'') is being, or is likely to be, sold in the United States at less than fair value (``LTFV''), as provided in section 733 of the Tariff Act of 1930, as amended (the ``Act''). The estimated dumping margins are shown in the ``Preliminary Determination'' section of this notice. Interested parties are invited to comment on the preliminary determination.

Geometry and the onset of rigidity in a disordered network

NASA Astrophysics Data System (ADS)

Vermeulen, Mathijs F. J.; Bose, Anwesha; Storm, Cornelis; Ellenbroek, Wouter G.

2017-11-01

Disordered spring networks that are undercoordinated may abruptly rigidify when sufficient strain is applied. Since the deformation in response to applied strain does not change the generic quantifiers of network architecture, the number of nodes and the number of bonds between them, this rigidity transition must have a geometric origin. Naive, degree-of-freedom-based mechanical analyses such as the Maxwell-Calladine count or the pebble game algorithm overlook such geometric rigidity transitions and offer no means of predicting or characterizing them. We apply tools that were developed for the topological analysis of zero modes and states of self-stress on regular lattices to two-dimensional random spring networks and demonstrate that the onset of rigidity, at a finite simple shear strain γ★, coincides with the appearance of a single state of self-stress, accompanied by a single floppy mode. The process conserves the topologically invariant difference between the number of zero modes and the number of states of self-stress but imparts a finite shear modulus to the spring network. Beyond the critical shear, the network acquires a highly anisotropic elastic modulus, resisting further deformation most strongly in the direction of the rigidifying shear. We confirm previously reported critical scaling of the corresponding differential shear modulus. In the subcritical regime, a singular value decomposition of the network's compatibility matrix foreshadows the onset of rigidity by way of a continuously vanishing singular value corresponding to the nascent state of self-stress.

Condensin confers the longitudinal rigidity of chromosomes.

PubMed

Houlard, Martin; Godwin, Jonathan; Metson, Jean; Lee, Jibak; Hirano, Tatsuya; Nasmyth, Kim

2015-06-01

In addition to inter-chromatid cohesion, mitotic and meiotic chromatids must have three physical properties: compaction into 'threads' roughly co-linear with their DNA sequence, intra-chromatid cohesion determining their rigidity, and a mechanism to promote sister chromatid disentanglement. A fundamental issue in chromosome biology is whether a single molecular process accounts for all three features. There is universal agreement that a pair of Smc-kleisin complexes called condensin I and II facilitate sister chromatid disentanglement, but whether they also confer thread formation or longitudinal rigidity is either controversial or has never been directly addressed respectively. We show here that condensin II (beta-kleisin) has an essential role in all three processes during meiosis I in mouse oocytes and that its function overlaps with that of condensin I (gamma-kleisin), which is otherwise redundant. Pre-assembled meiotic bivalents unravel when condensin is inactivated by TEV cleavage, proving that it actually holds chromatin fibres together.

Origami-Inspired Folding of Thick, Rigid Panels

NASA Technical Reports Server (NTRS)

Trease, Brian P.; Thomson, Mark W.; Sigel, Deborah A.; Walkemeyer, Phillip E.; Zirbel, Shannon; Howell, Larry; Lang, Robert

2014-01-01

To achieve power of 250 kW or greater, a large compression ratio of stowed-to-deployed area is needed. Origami folding patterns were used to inspire the folding of a solar array to achieve synchronous deployment; however, origami models are generally created for near-zero-thickness material. Panel thickness is one of the main challenges of origami-inspired design. Three origami-inspired folding techniques (flasher, square twist, and map fold) were created with rigid panels and hinges. Hinge components are added to the model to enable folding of thick, rigid materials. Origami models are created assuming zero (or near zero) thickness. When a material with finite thickness is used, the panels are required to bend around an increasingly thick fold as they move away from the center of the model. The two approaches for dealing with material thickness are to use membrane hinges to connect the panels, or to add panel hinges, or hinges of the same thickness, at an appropriate width to enable folding.

Photogeneration of Charge Carriers in Bilayer Assemblies of Conjugated Rigid-Rod Polymers

DTIC Science & Technology

1994-07-08

photoinduced electron transfer and exciplex formation at the bilayer interface. Thus photocarrier generation on photoexcitation of the conjugated rigid...rod polymers in the bilayer occurs by photoinduced electron transfer, forming intermolecular exciplexes which dissociate efficiently in electric field...photogeneration, conjugated rigid-rod polymers, is. MACI COD bilayer assemblies, electron transfer, exciplexes . 11. SEOJUTY CLASUICA 10. 51(11MIE CLASSIMIAVION

Statistical Analysis of Bending Rigidity Coefficient Determined Using Fluorescence-Based Flicker-Noise Spectroscopy.

PubMed

Doskocz, Joanna; Drabik, Dominik; Chodaczek, Grzegorz; Przybyło, Magdalena; Langner, Marek

2018-06-01

Bending rigidity coefficient describes propensity of a lipid bilayer to deform. In order to measure the parameter experimentally using flickering noise spectroscopy, the microscopic imaging is required, which necessitates the application of giant unilamellar vesicles (GUV) lipid bilayer model. The major difficulty associated with the application of the model is the statistical character of GUV population with respect to their size and the homogeneity of lipid bilayer composition, if a mixture of lipids is used. In the paper, the bending rigidity coefficient was measured using the fluorescence-enhanced flicker-noise spectroscopy. In the paper, the bending rigidity coefficient was determined for large populations of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and 1,2-dioleoyl-sn-glycero-3-phosphocholine vesicles. The quantity of obtained experimental data allows to perform statistical analysis aiming at the identification of the distribution, which is the most appropriate for the calculation of the value of the membrane bending rigidity coefficient. It has been demonstrated that the bending rigidity coefficient is characterized by an asymmetrical distribution, which is well approximated with the gamma distribution. Since there are no biophysical reasons for that we propose to use the difference between normal and gamma fits as a measure of the homogeneity of vesicle population. In addition, the effect of a fluorescent label and types of instrumental setups on determined values has been tested. Obtained results show that the value of the bending rigidity coefficient does not depend on the type of a fluorescent label nor on the type of microscope used.