Predictors of Exercise-Induced Pulmonary Hypertension in Patients with Asymptomatic Degenerative Mitral Regurgitation: Mechanistic Insights from 2D Speckle-Tracking Echocardiography

PubMed Central

Kamijima, Ryo; Suzuki, Kengo; Izumo, Masaki; Kuwata, Shingo; Mizukoshi, Kei; Takai, Manabu; Kou, Seisyou; Hayashi, Akio; Kida, Keisuke; Harada, Tomoo; Akashi, Yoshihiro J.

2017-01-01

Presence of exercise-induced pulmonary hypertension (EIPH) in asymptomatic degenerative mitral regurgitation (DMR) determines prognosis. This study aimed to elucidate the mechanism and predictors of EIPH in asymptomatic DMR. Ninety-one consecutive asymptomatic patients with DMR who underwent exercise stress echocardiography were prospectively included. We obtained various conventional echocardiographic parameters at rest and during peak exercise, as well as left atrial (LA) function at rest using 2-dimensional speckle-tracking analysis. The 25 patients (33.3%) with EIPH were significantly older and had a greater ratio of mitral peak velocity of early filling to early diastolic mitral annular velocity during peak exercise than those without EIPH. LA strain (LAS)-s and LAS-e, indices of LA reservoir and conduit function, respectively, were significantly lower in those with EIPH than in those without EIPH. Multivariate analysis indicated that LAS-s was the only resting echocardiographic parameter that independently predicted EIPH, with a cut-off value of 26.9%. Furthermore, Kaplan-Meier curve analysis showed that symptom-free survival was markedly lower among those with reduced LAS-s. In conclusion, decreased LA reservoir function contributes to EIPH, and LAS-s at rest is a useful indicator for predicting EIPH in asymptomatic patients with DMR. PMID:28071674

Localized Ambient Solidity Separation Algorithm Based Computer User Segmentation

PubMed Central

Sun, Xiao; Zhang, Tongda; Chai, Yueting; Liu, Yi

2015-01-01

Most of popular clustering methods typically have some strong assumptions of the dataset. For example, the k-means implicitly assumes that all clusters come from spherical Gaussian distributions which have different means but the same covariance. However, when dealing with datasets that have diverse distribution shapes or high dimensionality, these assumptions might not be valid anymore. In order to overcome this weakness, we proposed a new clustering algorithm named localized ambient solidity separation (LASS) algorithm, using a new isolation criterion called centroid distance. Compared with other density based isolation criteria, our proposed centroid distance isolation criterion addresses the problem caused by high dimensionality and varying density. The experiment on a designed two-dimensional benchmark dataset shows that our proposed LASS algorithm not only inherits the advantage of the original dissimilarity increments clustering method to separate naturally isolated clusters but also can identify the clusters which are adjacent, overlapping, and under background noise. Finally, we compared our LASS algorithm with the dissimilarity increments clustering method on a massive computer user dataset with over two million records that contains demographic and behaviors information. The results show that LASS algorithm works extremely well on this computer user dataset and can gain more knowledge from it. PMID:26221133

Learning Design at White Sands Test Facility

NASA Technical Reports Server (NTRS)

Grotewiel, Shane

2010-01-01

During the Fall of 2010, I spent my time at NASA White Sands Test Facility in Las Cruces, NM as an Undergraduate Student Research Program (USRP) Intern. During that time, I was given three projects to work on: Large Altitude Simulation System (LASS) basket strainer, log books, and the design of a case for touch screen monitors used for simulations. I spent most of my time on the LASS basket strainer. The LASS system has a water feed line with a basket strainer that filters out rust. In 2009, there were three misfires which cost approximately $27,000 and about 8% of the allotted time. The strainer was getting a large change in pressure that would result in a shutdown of the system. I have designed a new basket that will eliminate the large pressure change and it can be used with the old basket strainer housing. The LASS system has three steam generators (modules). Documents pertaining to these modules are stored electronically, and the majority of the documents are not able to be searched with keywords, so they have to be gone through one by one. I have come up with an idea on how to organize these files so that the Propulsion Department may efficiently search through the documents needed. Propulsion also has a LASS simulator that incorporates two touch screen monitors. Currently these monitors are in six foot by two foot metal cabinet on wheels. During simulation these monitors are used in the block house and need to be taken out of the block house when not in use. I have designed different options for hand held cases for storing and transporting the monitors in and out of the block house. The three projects previously mentioned demonstrate my contributions to the Propulsion Department and have taught me real world experience that is essential in becoming a productive engineer.

Genetics Home Reference: dystonia 6

MedlinePlus

... neck, causing problems with speaking (dysarthria) and eating (dysphagia). Eyelid twitching (blepharospasm) may also occur. Involvement of ... dystonia, DYT6 type The Bachmann-Strauss Dystonia and Parkinson Foundation: What Is Dystonia? Patient Support and Advocacy ...

Genetics Home Reference: restless legs syndrome

MedlinePlus

... P, Ripke S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Högl B, ... W, Peglau I, Vodicka P, Vávrová J, Sonka K, Nevsimalova S, Montplaisir J, Turecki G, Rouleau G, Gieger ...

Development of an analytical procedure to study linear alkylbenzenesulphonate (LAS) degradation in sewage sludge-amended soils.

PubMed

Comellas, L; Portillo, J L; Vaquero, M T

1993-12-24

A procedure for determining linear alkylbenzenesulphonates (LASs) in sewage sludge and amended soils has been developed. Extraction by sample treatment with 0.5 M potassium hydroxide in methanol and reflux was compared with a previously described extraction procedure in Soxhlet with methanol and solid sodium hydroxide in the sample. Repeatability results were similar with savings in extraction time, solvents and evaporation time. A clean-up method involving a C18 cartridge has been developed. Analytes were quantified by a reversed-phase HPLC method with UV and fluorescence detectors. Recoveries obtained were higher than 84%. The standing procedure was applied to high doses of sewage sludge-amended soils (15%) with increasing quantities of added LASs. Degradation data for a 116-day period are presented.

Spatial distribution, temporal variation and specificity of microhabitat of Tropisternus species (Coleoptera: Hydrophilidae) in permanent ponds.

PubMed

Gómez Lutz, M C; Kehr, A I; Fernández, L A

2015-06-01

The spatial distribution and temporal variation of 11 species of Tropisternus were analyzed in two permanent ponds located in the province of Corrientes, Argentina. Samples were collected every 15 days, between October 2010 and March 2011. The species recorded were Tropisternus collaris (Fabricius), Tropisternus ovalis Castelnau, Tropisternus laevis (Sturm), Tropisternus lateralis limbatus (Brullé), Tropisternus longispina Fernández & Bachmann, Tropisternus carinispina Orchymont, Tropisternus bourmeisteri Fernández & Bachmann, Tropisternus apicipalpis (Chevrolat), Tropisternus dilatatus Bruch, Tropisternus obesus Bruch, and Tropisternus ignoratus Knisch. The first four were present in higher proportions than the remaining during most of the study period. The spatial distribution of individuals was mostly related to the homogeneity or heterogeneity of the ecosystem in relation to microhabitats with aquatic vegetation: In ponds with different microhabitats, individuals were mainly aggregated, whereas in ponds with homogenous features, individuals were randomly distributed. However, when species were analyzed individually, the spatial distribution and the use of microhabitat by each species were different with respect to preference and behavior.

Mapping gray-scale image to 3D surface scanning data by ray tracing

NASA Astrophysics Data System (ADS)

Li, Peng; Jones, Peter R. M.

1997-03-01

The extraction and location of feature points from range imaging is an important but difficult task in machine vision based measurement systems. There exist some feature points which are not able to be detected from pure geometric characteristics, particularly in those measurement tasks related to the human body. The Loughborough Anthropometric Shadow Scanner (LASS) is a whole body surface scanner based on structured light technique. Certain applications of LASS require accurate location of anthropometric landmarks from the scanned data. This is sometimes impossible from existing raw data because some landmarks do not appear in the scanned data. Identification of these landmarks has to resort to surface texture of the scanned object. Modifications to LASS were made to allow gray-scale images to be captured before or after the object was scanned. Two-dimensional gray-scale image must be mapped to the scanned data to acquire the 3D coordinates of a landmark. The method to map 2D images to the scanned data is based on the colinearity conditions and ray-tracing method. If the camera center and image coordinates are known, the corresponding object point must lie on a ray starting from the camera center and connecting to the image coordinate. By intersecting the ray with the scanned surface of the object, the 3D coordinates of a point can be solved. Experimentation has demonstrated the feasibility of the method.

Debate Revives Old Arguments on HPV Vaccine

ERIC Educational Resources Information Center

Shah, Nirvi

2011-01-01

The author reports on a Republican presidential debate which revives the contention over requiring middle school girls to be vaccinated against the virus that causes cervical cancer. At the September 12 debate, U.S. Representative Michele Bachmann, of Minnesota, and Rick Santorum, a former U.S. senator from Pennsylvania, attacked Texas Governor…

Carbon and nitrogen isotope ratios of factory-produced RDX and HMX.

PubMed

Howa, John D; Lott, Michael J; Chesson, Lesley A; Ehleringer, James R

2014-07-01

RDX and HMX are explosive compounds commonly used by the military and also occasionally associated with acts of terrorism. The isotopic characterization of an explosive can be a powerful approach to link evidence to an event or an explosives cache. We sampled explosive products and their reactants from commercial RDX manufacturers that used the direct nitration and/or the Bachmann synthesis process, and then analyzed these materials for carbon and nitrogen isotope ratios. For manufacturers using the Bachmann process, RDX (13)C enrichment relative to the hexamine substrate was small (+0.9‰) compared to RDX produced using the direct nitration process (+8.2‰ to +12.0‰). RDX (15)N depletion relative to the nitrogen-containing substrates (-3.6‰) was smaller in the Bachmann process than in the direct nitration process (-12.6‰ to -10.6‰). The sign and scale of these differences agree with theorized mechanisms of mass-dependent fractionation. We also examined the isotopic relationship between RDX and HMX isolated from explosive samples. The δ(13)C and δ(15)N values of RDX generally matched those of the HMX with few exceptions, most notably from a manufacturer known to make RDX using two different synthesis processes. The range in δ(13)C values of RDX in a survey of 100 samples from 12 manufacturers spanned 33‰ while the range spanned by δ(15)N values was 26‰; these ranges were much greater than any previously published observations. Understanding the relationship between products and reactants further explains the observed variation in industrially manufactured RDX and can be used as a diagnostic tool to analyze explosives found at a crime scene. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Second-Degree Interatrial Block in Hemodialysis Patients

PubMed Central

Enriquez, Andres; D'Amato, Anna; de Luna, Antoni Bayes; Baranchuk, Adrian

2015-01-01

Interatrial conduction delays manifest as a prolonged P-wave duration on surface ECG and the term interatrial block (IAB) has been coined. They are usually fixed, but cases of intermittent IAB have been described, suggesting functional conduction block at the Bachmann bundle region. We report 2 cases of patients on chronic hemodialysis therapy presenting with intermittent IAB. PMID:25755895

Development of routines for simultaneous in situ chemical composition and stable Si isotope ratio analysis by femtosecond laser ablation inductively coupled plasma mass spectrometry.

PubMed

Frick, Daniel A; Schuessler, Jan A; von Blanckenburg, Friedhelm

2016-09-28

Stable metal (e.g. Li, Mg, Ca, Fe, Cu, Zn, and Mo) and metalloid (B, Si, Ge) isotope ratio systems have emerged as geochemical tracers to fingerprint distinct physicochemical reactions. These systems are relevant to many Earth Science questions. The benefit of in situ microscale analysis using laser ablation (LA) over bulk sample analysis is to use the spatial context of different phases in the solid sample to disclose the processes that govern their chemical and isotopic compositions. However, there is a lack of in situ analytical routines to obtain a samples' stable isotope ratio together with its chemical composition. Here, we evaluate two novel analytical routines for the simultaneous determination of the chemical and Si stable isotope composition (δ(30)Si) on the micrometre scale in geological samples. In both routines, multicollector inductively coupled plasma mass spectrometry (MC-ICP-MS) is combined with femtosecond-LA, where stable isotope ratios are corrected for mass bias using standard-sample-bracketing with matrix-independent calibration. The first method is based on laser ablation split stream (LASS), where the laser aerosol is split and introduced simultaneously into both the MC-ICP-MS and a quadrupole ICP-MS. The second method is based on optical emission spectroscopy using direct observation of the MC-ICP-MS plasma (LA-MC-ICP-MS|OES). Both methods are evaluated using international geological reference materials. Accurate and precise Si isotope ratios were obtained with an uncertainty typically better than 0.23‰, 2SD, δ(30)Si. With both methods major element concentrations (e.g., Na, Al, Si, Mg, Ca) can be simultaneously determined. However, LASS-ICP-MS is superior over LA-MC-ICP-MS|OES, which is limited by its lower sensitivity. Moreover, LASS-ICP-MS offers trace element analysis down to the μg g(-1)-range for more than 28 elements due to lower limits of detection, and with typical uncertainties better than 15%. For in situ simultaneous

Silicon solar cell process development, fabrication, and analysis

NASA Technical Reports Server (NTRS)

Yoo, H. I.; Iles, P. A.; Leung, D. C.

1981-01-01

Work has progressed in fabrication and characterization of solar cells from ubiquitous crystallization process (UCP) wafers and LASS ribbons. Gettering tests applied to UCP wafers made little change on their performance compared with corresponding baseline data. Advanced processes such as shallow junction (SJ), back surface field (BSF), and multilayer antireflection (MLAR) were also applied. While BSF by Al paste had shunting problems, cells with SJ and BSF by evaporated Al, and MLAR did achieve 14.1% AMI on UCP silicon. The study of LASS material was very preliminary. Only a few cells with SJ, BSR, (no BSF) and MLAR were completed due to mechanical yield problems after lapping the material. Average efficiency was 10.7% AMI with 13.4% AMI for CZ controls. Relatively high minority carrier diffusion lengths were obtained. The lower than expected Jsc could be partially explained by low active area due to irregular sizes.

Genetics Home Reference: Chanarin-Dorfman syndrome

MedlinePlus

... abnormalities in the ichthyoses: inherited disorders of lipid metabolism. J Lipid Res. 2008 Apr;49(4):697-714. doi: 10.1194/jlr.R800002-JLR200. Epub 2008 Feb 2. Review. Citation on PubMed or Free article on PubMed Central Lass A, Zimmermann R, Haemmerle ...

Evidence review for the 2016 International Ankle Consortium consensus statement on the prevalence, impact and long-term consequences of lateral ankle sprains.

PubMed

Gribble, Phillip A; Bleakley, Chris M; Caulfield, Brian M; Docherty, Carrie L; Fourchet, François; Fong, Daniel Tik-Pui; Hertel, Jay; Hiller, Claire E; Kaminski, Thomas W; McKeon, Patrick O; Refshauge, Kathryn M; Verhagen, Evert A; Vicenzino, Bill T; Wikstrom, Erik A; Delahunt, Eamonn

2016-12-01

Lateral ankle sprains (LASs) are the most prevalent musculoskeletal injury in physically active populations. They also have a high prevalence in the general population and pose a substantial healthcare burden. The recurrence rates of LASs are high, leading to a large percentage of patients with LAS developing chronic ankle instability. This chronicity is associated with decreased physical activity levels and quality of life and associates with increasing rates of post-traumatic ankle osteoarthritis, all of which generate financial costs that are larger than many have realised. The literature review that follows expands this paradigm and introduces emerging areas that should be prioritised for continued research, supporting a companion position statement paper that proposes recommendations for using this summary of information, and needs for specific future research. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

The Effect of the Balance of Orthographic Neighborhood Distribution in Visual Word Recognition

ERIC Educational Resources Information Center

Robert, Christelle; Mathey, Stephanie; Zagar, Daniel

2007-01-01

The present study investigated whether the balance of neighborhood distribution (i.e., the way orthographic neighbors are spread across letter positions) influences visual word recognition. Three word conditions were compared. Word neighbors were either concentrated on one letter position (e.g.,nasse/basse-lasse-tasse-masse) or were unequally…

Hawaii-Hyperspectral Airborne Remote Environmental Sensing (HIHARES󈧍) Experiment

DTIC Science & Technology

2012-03-15

Polynesia and southeastern Asia. Cordia sebestena Kou haole Found worldwide, mostly in warmer regions. Cordyline fruticosa Ti plant It is native to...to obtain spectra of vegetation indigenous to Oahu and from several specialty gardens, spectra of plants common to Australia. Hawaii Coastal...indigenous to Oahu and from several specialty gardens, spectra of plants common to Australia. On November 19, 2008, Dr. Chip Bachmann, Mssrs Mattis and

NRL Hyperspectral Imagery Trafficability Tool (HITT): Software andSpectral-Geotechnical Look-up Tables for Estimation and Mapping of Soil Bearing Strength from Hyperspectral Imagery

DTIC Science & Technology

2012-09-28

spectral-geotechnical libraries and models developed during remote sensing and calibration/ validation campaigns conducted by NRL and collaborating...geotechnical libraries and models developed during remote sensing and calibration/ validation campaigns conducted by NRL and collaborating institutions in four...2010; Bachmann, Fry, et al, 2012a). The NRL HITT tool is a model for how we develop and validate software, and the future development of tools by

Methodical Design of Software Architecture Using an Architecture Design Assistant (ArchE)

DTIC Science & Technology

2005-04-01

PA 15213-3890 Methodical Design of Software Architecture Using an Architecture Design Assistant (ArchE) Felix Bachmann and Mark Klein Software...DATES COVERED 00-00-2005 to 00-00-2005 4. TITLE AND SUBTITLE Methodical Design of Software Architecture Using an Architecture Design Assistant...important for architecture design – quality requirements and constraints are most important Here’s some evidence: If the only concern is

Epicardial Breakthrough Waves During Sinus Rhythm: Depiction of the Arrhythmogenic Substrate?

PubMed

Mouws, Elisabeth M J P; Lanters, Eva A H; Teuwen, Christophe P; van der Does, Lisette J M E; Kik, Charles; Knops, Paul; Bekkers, Jos A; Bogers, Ad J J C; de Groot, Natasja M S

2017-09-01

Epicardial breakthrough waves (EBW) during atrial fibrillation are important elements of the arrhythmogenic substrate and result from endo-epicardial asynchrony, which also occurs to some degree during sinus rhythm (SR). We examined the incidence and characteristics of EBW during SR and its possible value in the detection of the arrhythmogenic substrate associated with atrial fibrillation. Intraoperative epicardial mapping (interelectrode distances 2 mm) of the right atrium, Bachmann's bundle, the left atrioventricular groove, and the pulmonary vein area was performed during SR in 381 patients (289 male, 67±10 years) with ischemic or valvular heart disease. EBW were referred to as sinus node breakthrough waves if they were the earliest right atrial activated site. A total of 218 EBW and 57 sinus node breakthrough waves were observed in 168 patients (44%). EBW mostly occurred at right atrium (N=105, 48%) and left atrioventricular groove (N=67, 31%), followed by Bachmann's bundle (N=27, 12%) and pulmonary vein area (N=19, 9%; P <0.001). EBW occurred most often in ischemic heart disease patients (N=114, 49%) compared with (ischemic and) valvular heart disease patients (N=26, 17%; P <0.001). EBW electrograms most often consisted of double and fractionated potentials (N=137, 63%). In case of single potentials, an R wave was observed in 88% (N=71) of EBW, as opposed to 21% of sinus node breakthrough waves (N=5; P <0.001). Fractionated EBW potentials were more often observed at the right atrium and Bachmann's bundle ( P <0.001). During SR, EBW are present in over a third of patients, particularly in thicker parts of the atrial wall. Features of SR EBW indicate that muscular connections between endo- and epicardium underlie EBW and that a slight degree of endo-epicardial asynchrony required for EBW to occur is already present in some areas during SR. Hence, an anatomic substrate is present, which may enhance the occurrence of EBW during atrial fibrillation, thereby

Quantifying the timescales of Archean UHT metamorphism through U-Pb monazite and zircon petrochronology

NASA Astrophysics Data System (ADS)

Guevara, V.; MacLennan, S. A.; Schoene, B.; Dragovic, B.; Caddick, M. J.; Kylander-Clark, A. R.; Couëslan, C. G.

2016-12-01

Unraveling the timescales of metamorphism is crucial to understanding the mechanisms behind mass/heat transfer through Earth's crust. Though such mechanisms and their durations are becoming well constrained in modern (Phanerozoic) settings, the drivers of metamorphism in the ancient geologic record remain more enigmatic. The development of accessory phase petrochronology has allowed metamorphic evolution to be closely linked to isotopic dates, ultimately improving quantification of metamorphic durations. While in-situ petrochronological methods preserve textural and spatial context, they often lack the temporal resolution required to accurately quantify metamorphic duration in Archean terranes. Here we combine in-situ U-Pb monazite (mnz) and zircon (zrn) laser ablation split-stream (LASS) and high-precision ID-TIMS-TEA petrochronology of distinct grain domains to resolve the timescales of ultrahigh temperature (UHT) metamorphism in the Archean Pikwitonei granulite domain (PGD). The PGD encompasses >1.5x105 km2 of granulite-facies rocks on the NW edge of the Superior Province. Themodynamic modelling of a pelite from the western part of the PGD suggests peak P-T conditions of >8 kbar, 900-940 °C and UHT decompression to 8 kbar followed by cooling. LASS analysis of zrn inclusions in garnet (grt) yields a date of 2701 Ma, with Ti in zrn thermometry yielding T of 800-900 °C. LASS analysis of mnz yields dates of 2720-2680 Ma for low HREE domains with no to shallow negative Eu anomalies, suggestive of growth during plagioclase (plg) breakdown and grt stability. ID-TIMS analysis of a mnz fragment with a strong negative Eu anomaly, suggestive of growth during plg stability, gives a concordant 207Pb/206Pb date of 2666 Ma, consistent with LASS results of 2660-2640 Ma for chemically similar domains. ID-TIMS analyses of zrn rims yield a range of 207Pb/206Pb dates from 2671 to 2656 Ma (±<1 Ma). Ti in zrn yields 800 °C for these rims, indicating they grew at similar T

Psychometric Properties of a Suicide Screen for Adjudicated Youth in Residential Care

ERIC Educational Resources Information Center

Langhinrichsen-Rohling, Jennifer; Hudson, Kenneth; Lamis, Dorian A.; Carr, Nicole

2012-01-01

There is a need to efficiently and effectively screen adjudicated youth residing within the juvenile justice system for suicide proneness. Accordingly, in the current study, the psychometric properties of the Life Attitude Schedule: Short Form (LAS:S), a 24-item risk assessment for suicide proneness, were assessed using data from adjudicated youth…

Automation and Cataloging.

ERIC Educational Resources Information Center

Furuta, Kenneth; And Others

1990-01-01

These three articles address issues in library cataloging that are affected by automation: (1) the impact of automation and bibliographic utilities on professional catalogers; (2) the effect of the LASS microcomputer software on the cost of authority work in cataloging at the University of Arizona; and (3) online subject heading and classification…

78 FR 35047 - Notice of Application for Withdrawal and Opportunity for Public Meeting; Oregon

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-11

... to contact either of the above individuals. The FIRS is available 24 hours a day, 7 days a week, to... regular business hours, 8 a.m. to 4 p.m., Monday through Friday, except Federal holidays. Before including... mine reclamation work completed at the White King/Lucky Lass Mine reclamation project area. This notice...

DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina.

PubMed

Zullo, Joseph M; Demarco, Ignacio A; Piqué-Regi, Roger; Gaffney, Daniel J; Epstein, Charles B; Spooner, Chauncey J; Luperchio, Teresa R; Bernstein, Bradley E; Pritchard, Jonathan K; Reddy, Karen L; Singh, Harinder

2012-06-22

A large fraction of the mammalian genome is organized into inactive chromosomal domains along the nuclear lamina. The mechanism by which these lamina associated domains (LADs) are established remains to be elucidated. Using genomic repositioning assays, we show that LADs, spanning the developmentally regulated IgH and Cyp3a loci contain discrete DNA regions that associate chromatin with the nuclear lamina and repress gene activity in fibroblasts. Lamina interaction is established during mitosis and likely involves the localized recruitment of Lamin B during late anaphase. Fine-scale mapping of LADs reveals numerous lamina-associating sequences (LASs), which are enriched for a GAGA motif. This repeated motif directs lamina association and is bound by the transcriptional repressor cKrox, in a complex with HDAC3 and Lap2β. Knockdown of cKrox or HDAC3 results in dissociation of LASs/LADs from the nuclear lamina. These results reveal a mechanism that couples nuclear compartmentalization of chromatin domains with the control of gene activity. Copyright © 2012 Elsevier Inc. All rights reserved.

Titanite petrochronology in the Fish Canyon Tuff

NASA Astrophysics Data System (ADS)

Schmitz, M. D.; Crowley, J. L.

2014-12-01

The petrologic complexity of the archtypical 'monotonous intermediate' Fish Canyon Tuff (FCT) has been previously established by a variety of mineralogical and geochemical proxies [1-2], and the unusual storage and eruptive dynamics of the FCT have been delineated by several geochronological studies [3-5]. Titanite is an apparent equilibrium phase in the penultimate FCT magma, and can be linked petrographically to hornblende crystals that preserve up-temperature core-to-rim zoning profiles. As a reactive, trace element-rich phase, we hypothesized that titanite may record an intracrystalline record of magma chamber dynamics. Titanite crystals from the same separate analyzed in [4] were oriented and doubly-polished to yield characteristic wedge-shaped cross-sectional wafers approximately 300 µm in thickness. BSE imaging guided LA-ICPMS analyses of a full suite of trace elements using a 25 µm beam diameter and crater depth on multiple locations across both sides of the wafer. Most titanite crystals are characterized by large variations in trace elements, including at least two generations of REE-enriched, actinide-poor, low Sr, large Eu anomaly cores overgrown by REE-depleted, actinide-rich, high Sr domains with small Eu anomalies and distinctive concave-up middle to heavy REE patterns. Trace element contents and patterns correlate strongly with Eu anomaly; intermediate compositions are abundant and spatially correlated to reaction zones between core and rim domains. Within the context of the batholithic rejuvenation model for the FCT magma [1-2], these trace element variations are interpreted to record the partial melting of a differentiated crystalline FCT precursor and its hybridization with a more 'mafic' flux. ID-TIMS dating of end-member titanites confirm older ages (ca 28.4 to 29.0 Ma) for cores and define a younger age for rejuvenation of ca 28.2 Ma, consistent with recent U-Pb zircon and 40Ar/39Ar studies [5-7]. [1] Bachmann & Dungan (2002) Am Mineral 87

Baltimore Integrated Environmental Management Project ...

EPA Pesticide Factsheets

... in so ...lr ï´ _.. "ll"* S ** ^53 .£ï* 5 . ïa-J 3 S ß*1-S 2^ß S SljJ i;5 t> fiji:* * = 1 * -3 a *:;; ´l´i| |||| Isil IIJI'I-- s^i". s^s^is ff^-881 =ï´-'-- 1-31 i S5K-S 3 " ´-5 l-aSS ...

Correlation on Noisy Images

DTIC Science & Technology

1980-06-01

lass,,., tassel eageeteg, assesses, sets,,e as isles lasgeges eegtal ages,,,, 5 iS gel it, seisteis 5 5,5 essla see, Sieges 5,5,55 Ill SIas ...jujNT iAALL STORE Nzv 2 SCALL FILTERINEDGE)CALL OPER(N,TEDGEi ,ALL P UTO bI (04 CALL POsUUT(4) 3 O CONTINUE END 49 APPENDIX B -Continued SUBROUTINE

Studies on the Preparation and Properties of RDX

DTIC Science & Technology

1943-08-24

OF SCIENTIFIC RESEARCH AND DEVELOPMENT Report on " Studies on the Preparation and Properties of RDXn to August 15, 1942 by W. E. Bachmann OSRD...University of i"ichi|*an. I- i Roger Adaa»# Chairnan by Harris 1.. Chadwcll Technical .«tdo ! ’■JHUtNii/i : B. STUDIES ON THE PREPARATION AND...Rocovory of Anconiun Nitrate . . • »34 E. STUDIES ON BSX . . . . . • .35 1. Proparr.ticn of BSX . . • • • .36 2

Open control/display system for a telerobotics work station

NASA Technical Reports Server (NTRS)

Keslowitz, Saul

1987-01-01

A working Advanced Space Cockpit was developed that integrated advanced control and display devices into a state-of-the-art multimicroprocessor hardware configuration, using window graphics and running under an object-oriented, multitasking real-time operating system environment. This Open Control/Display System supports the idea that the operator should be able to interactively monitor, select, control, and display information about many payloads aboard the Space Station using sets of I/O devices with a single, software-reconfigurable workstation. This is done while maintaining system consistency, yet the system is completely open to accept new additions and advances in hardware and software. The Advanced Space Cockpit, linked to Grumman's Hybrid Computing Facility and Large Amplitude Space Simulator (LASS), was used to test the Open Control/Display System via full-scale simulation of the following tasks: telerobotic truss assembly, RCS and thermal bus servicing, CMG changeout, RMS constrained motion and space constructible radiator assembly, HPA coordinated control, and OMV docking and tumbling satellite retrieval. The proposed man-machine interface standard discussed has evolved through many iterations of the tasks, and is based on feedback from NASA and Air Force personnel who performed those tasks in the LASS.

Proceedings of the Annual Symposium on Frequency Control (38th) Held in Philadelphia, Pennsylvania on 29 May - 1 June 1984

DTIC Science & Technology

1984-06-01

with that of 1. Introduction LiTaO3. The velocity is almost equal, but the coupling factor of LiNbO 3 is 1.3 times higher than that of Electronic devices...R.D. ’indlin, "An Introduction to zhe Mathematical 3 4 2 5 6 MidiPresent Mason (oa Bachmann Adams Kahan Theory of Vibrations of Elastic Plates...GHz ), and gives a good reproductibility of the dielectric constant er INTRODUCTION ( typically : 37 + 0,5 ). The extension to higher and higher

1952 midsummer fuel moistures in Oregon and Washington national forests compared with other years.

Treesearch

Owen P. Cramer

1953-01-01

The inflammability of Oregon and Washington national forests during the middle of the 1952 fire season was slightly lass than the 12-year record high set in 1951 (table 1). The rating is based on the 25 lowest daily observations of fuel-moisture indicator sticks in the July 16 to August 21 period. Stick readings from 64 key fire-danger stations near the exterior...

NRL SSD Research Achievements: 19701980. Volume 2

DTIC Science & Technology

2015-10-30

Astronomy Observatory (HEAO-1) was launched, which carried the very large NRL SSD Large Area Sky Survey (LASS) experiment (HEAO-1 A1). These X-ray...overview of this research. High energy space environment research was fundamentally advanced in the 1970’s. The first High Energy Astronomy ...larger than any previously flown X-ray astronomy spacecraft, and the X-ray detectors provided the most comprehensive X-ray catalogue of astrophysical

JPRS Report, West Europe.

DTIC Science & Technology

1987-07-31

Sees Earlier Elections 24 Setback for Privitization Movement, by Egon Balsby 25 Many Economic Problems Unsolved, by Lasse Ellegaard 28 First...Geisler, Inuit Ataqatigiit. Setback For Privitization Movement Copenhagen BERLINGSKE AFTEN in Danish 29 May - 4 Jun 87 pp lr 2 [Article by Egon Balsby...34Yes to Socialism — No to Privitization "! [Text] The two large parties in Greenland politics, Ätassut and Siumut, both suffered defeats in an

The Digital Distribution of Public Health News Surrounding the Human Papillomavirus Vaccination: A Longitudinal Infodemiology Study.

PubMed

Mahoney, L Meghan; Tang, Tang; Ji, Kai; Ulrich-Schad, Jessica

2015-01-01

New media changes the dissemination of public health information and misinformation. During a guest appearance on the Today Show, US Representative Michele Bachmann claimed that human papillomavirus (HPV) vaccines could cause "mental retardation". The purpose of this study is to explore how new media influences the type of public health information users access, as well as the impact to these platforms after a major controversy. Specifically, this study aims to examine the similarities and differences in the dissemination of news articles related to the HPV vaccination between Google News and Twitter, as well as how the content of news changed after Michele Bachmann's controversial comment. This study used a purposive sampling to draw the first 100 news articles that appeared on Google News and the first 100 articles that appeared on Twitter from August 1-October 31, 2011. Article tone, source, topics, concerns, references, publication date, and interactive features were coded. The intercoder reliability had a total agreement of .90. Results indicate that 44.0% of the articles (88/200) about the HPV vaccination had a positive tone, 32.5% (65/200) maintained a neutral tone, while 23.5% (47/200) presented a negative tone. Protection against diseases 82.0% (164/200), vaccine eligibility for females 75.5% (151/200), and side effects 59.0% (118/200) were the top three topics covered by these articles. Google News and Twitter articles significantly differed in article tone, source, topics, concerns covered, types of sources referenced in the article, and uses of interactive features. Most notably, topic focus changed from public health information towards political conversation after Bachmann's comment. Before the comment, the HPV vaccine news talked more often about vaccine dosing (P<.001), duration (P=.005), vaccine eligibility for females (P=.03), and protection against diseases (P=.04) than did the later pieces. After the controversy, the news topic shifted towards

Development of a Distributed Source Containment Transport, Transformation, and Fate (CTT&F) Sub-Model for Military Installations

DTIC Science & Technology

2007-08-01

includes soil erodibility terms from the Universal Soil Lass Equation ( USLE ) for estimating the overland sediment transport capacity (for both the x and y...q = unit flow rate of water = va h [L2/T] vc = critical velocity for erosion overland [L/T] K = USLE soil erodibility factor C = USLE soil ...cover factor P = USLE soil management practice factor Be = width of eroding surface in flow direction [L]. In channels, sediment particles can be

The Army Study Program Fiscal Year 1988 Report

DTIC Science & Technology

1988-03-24

Studies Institute (ATTN: AWCI) 4 Defense Nuclear Agency (ATTN: LASS) 1 Engineering Studies Center (ATTN: ESC) 5 Commandant: US Army War College (ATTN...Library) 5 US Navy War College (ATTN: Library) 5 US Air War College (ATTN: Library) 5 Chief of Naval Operations (ATTN: 0P916) 5 Headquarters, US Air... war . Agreement is needed on the key words describing Army functional areas and related terms and on the relationships among them and other factors

Radiation Hardness of Efratom M-100 Rubidium Frequency Standard

DTIC Science & Technology

1982-12-01

h i ghes t f l uence o f 6.15 x 1012n/crn2 t h e norma l i zed ac pho tocur ren ts were about 702 o f t he normal ized dc photo- c u r r...100, FRK, M-1000. Pyrex ( t r ade name of Corning Glass) . e Cells produced i n Munich use Schott Duran 50 g lass which i s nearly ident ica l

Bond Strength of Composite to Dentin using Resin-Modified Glass Ionomers as Bonding Agents

DTIC Science & Technology

2016-03-02

59 MDW/SGVU SUBJECT: Professional Presentation Approval 2 MAR 20 16 l. Your paper, entitl ed Bond Strength of Composite to Dentin using Resin...Modified G lass Ionomers as Bonding Agents presented at Journal of Dental Research with MDWI 41- 108, and has been assigned local fi le #16086. 2...Vandewalle /Civ/SGDTG (59th CSPG/SGVU) DECS I 5-009 PROTOCOL TITLE Bond Strength of Composite to Dentin using Resin-modified Glass lonomers as

Large Advanced Space Systems (LASS) computer-aided design program additions

NASA Technical Reports Server (NTRS)

Farrell, C. E.

1982-01-01

The LSS preliminary and conceptual design requires extensive iteractive analysis because of the effects of structural, thermal, and control intercoupling. A computer aided design program that will permit integrating and interfacing of required large space system (LSS) analyses is discussed. The primary objective of this program is the implementation of modeling techniques and analysis algorithms that permit interactive design and tradeoff studies of LSS concepts. Eight software modules were added to the program. The existing rigid body controls module was modified to include solar pressure effects. The new model generator modules and appendage synthesizer module are integrated (interfaced) to permit interactive definition and generation of LSS concepts. The mass properties module permits interactive specification of discrete masses and their locations. The other modules permit interactive analysis of orbital transfer requirements, antenna primary beam n, and attitude control requirements.

Advanced space system analysis software. Technical, user, and programmer guide

NASA Technical Reports Server (NTRS)

Farrell, C. E.; Zimbelman, H. F.

1981-01-01

The LASS computer program provides a tool for interactive preliminary and conceptual design of LSS. Eight program modules were developed, including four automated model geometry generators, an associated mass properties module, an appendage synthesizer module, an rf analysis module, and an orbital transfer analysis module. The existing rigid body controls analysis module was modified to permit analysis of effects of solar pressure on orbital performance. A description of each module, user instructions, and programmer information are included.

Depth and Motion Prediction for Earth Penetrators

DTIC Science & Technology

1978-06-01

multiple-layer targets. For targets with accurately knowni properties , the final-depth results are accurate ihný pret AM all13 EIIW FINVS S WLT n.- U lass S...Project hAl611o2AT2?, Task A2, Work Unit󈧊, " Effectiveness of Earth Penetrators in Various Geologic Environments." Mr. R. S. Bernard conducted the... effects in the selective destruction of localized targets (airfields, factories, utilities, etc.). The effectiveness of these weapons, however, is

European Science Notes. Volume 40, Number 9

DTIC Science & Technology

1986-09-01

15 invited speakers pre- oxygen ases s asaon dioxide and senting talks on various topics in the oxygen as well as ammonia, chlorine, hy-ara fbisnsr...tantalum oxides (H+), work involves the contributions of elec- special lasses (H+, Na+, K+), valinomy- trical engineers as well as chemists. cin (K), tetra...copy only devise circuitry but work on concep- may be obtained from me]) he derived a tual design as well . Incidentally, the theorem that gives the

Microcircuit Device Reliability Digital Detailed Data

DTIC Science & Technology

1976-01-01

TYPE s No. FUNCTION A LASS PINS TEMP. TYPE CLASS LEVEL I eFAILED 8 NO. CHIP TEST APPL. TEST PAR1 t T AGATES PROTECT. DATE E:V. D TYPE HOURST :708 FLIP...LEVEL # EFAILED s a NO. t CHIP i TEST 3 APPL. a TEST I PAR! 3 a GATES s PROTECT. a DATE 3 ENV. t TYPE I 3 -OUHb s 354H0( 3 GATE C-I CDIP 14 150C :11.A

Evaluation of Military Field-Water Quality. Volume 7. Performance Evaluation of the 600-GPH Reverse Osmosis Water Purification Unit (ROWPU): reverse Osmosis (RO) Components

DTIC Science & Technology

1986-02-01

Data-for ASsessingHealthRISKS In Potential Theaters ~ of Operation forU,5. Mil-itary._orces. Jf-jr cLAss t:cAToN 9; r-.$ ’AGg UNCLASSIFIED Volume 7...Bypass, Potable-Water Disinfection,_ and Water-Quality Analysis Techniques; and Vol. 9, Data for Assessing Health Risks in Potential Theaters of Operation ...cleaning the RO elements, with objectives of improving solute rejection and reducing operating pressure. The most common method is to flush citric acid

Inertial Survey Application to Civil Works,

DTIC Science & Technology

1983-01-01

closer together the ZUPTS must be performed. ZUPTS are used by the system to provide external information to the error control system used (Kalman...the best estimate of the system states. Accuracy of the system is increased when the sensor information from the inertial platform is compared with the...building a new version of its Auto-Surveyor System to be known as LASS II. This version will be based on the production model of the PADS presently

The rheology of crystal-rich magmas (Kuno Award Lecture)

NASA Astrophysics Data System (ADS)

Huber, Christian; Aldin Faroughi, Salah; Degruyter, Wim

2016-04-01

The rheology of magmas controls not only eruption dynamics but also the rate of transport of magmas through the crust and to a large extent the rate of magma differentiation and degassing. Magma bodies stalled in the upper crust are known to spend most of their lifespan above the solidus at a high crystal content (Cooper and Kent, 2014; Huber et al., 2009), where the probability of melt extraction (crystal fractionation) is the greatest (Dufek and Bachmann, 2010). In this study, we explore a new theoretical framework to study the viscosity of crystal bearing magmas. Since the seminal work of A. Einstein and W. Sutherland in the early 20th century, it has been shown theoretically and tested experimentally that a simple self-similar behavior exist between the relative viscosity of dilute (low crystal content) suspensions and the particle volume fraction. The self-similar nature of that relationship is quickly lost as we consider crystal fractions beyond a few volume percent. We propose that the relative viscosity of crystal-bearing magmas can be fully described by two state variables, the intrinsic viscosity and the crowding factor (a measure of the packing threshold in the suspension). These two state variables can be measured experimentally under different conditions, which allows us to develop closure relationships in terms of the applied shear stress and the crystal shape and size distributions. We build these closure equations from the extensive literature on the rheology of synthetic suspensions, where the nature of the particle shape and size distributions is better constrained and apply the newly developed model to published experiments on crystal-bearing magmas. We find that we recover a self-similar behavior (unique rheology curve) up to the packing threshold and show that the commonly reported break in slope between the relative viscosity and crystal volume fraction around the expected packing threshold is most likely caused by a sudden change in the state

Digital Screening and Halftone Techniques for Raster Processing,

DTIC Science & Technology

1980-01-14

I 7 A)-AO81 090 ARMY ENGINEER TOPOGRAPH4IC LASS FORT Bs.voiR VA 161/ OIGITAL SCREENING ANO HALFTONE TECNNIOUIES FOR RASTER PROCLPSINM-.TC(U) JAN GO R... HALFTONE TECHNIQUES 0FOR RASTER PROCESSING BY RICHARD L. ROSENTHAL DTIC FEB 𔃼 7 1980 W.A Approved for public release; distribution unlimited AU...creening and halftone techniques forlt -rastei’ processing ~ A 6. PERFORMING ORG. REPORT NUMBER 7. AUTNOP-r- S. CONTRACT OR GRANT NUMBER(*) c*t- Ri chard

Chemical Durability Improvement and Static Fatigue of Glasses.

DTIC Science & Technology

1982-08-01

Afl-Alla 837 RENSSELAER POLYIECmfJ!C INST TRtOY NY DEPT OF MATERIAL--ETC F/6 ii/ CHEMICAL DURABILITY IMPROVEMENT AND STATIC FATIGUE OF GLASSESW AUC2...82 M TOMOZAWA NOGGIN 7A-C-0315 UNC LASS IF IED N ENEEEEEE FINAL TECHNICAL REPORT For the period April 1, 1978 "u March 31, 198200 CHEMICAL DURABILITY...REPORT A PERIOD COVERED Chemical Durability Improvement and Static Final Technical Report Fatiue o GlasesApril 1, 1978"’,March 31, 1982 S. PERFORMING ORG

Optical Computing Research.

DTIC Science & Technology

1987-10-30

1489-1496, 1985. 13. W.T. Welford and R. Winston , The Optics of Nonimaging Concentrators , Academic Press, New York, N.Y., 1978 (see Appendix A). 14. R.H...34, Applied Optics , Vol. 25, pp. 3033-3046 (1986). 2. P. Idell and J.W. Goodman, "Design of optical imaging concentrators for partially coherent light: absolute...AD-fIB? Ŗ OPTICAL CONPIITINO RESEAIRCII(U STANFORD UlNIV CA STINFORD / ELECTRONICS LASS J N 0000W4 30 OCT 97 SMAFOSR-TR-S?-1635 RFOSR-96

Quantum 1/f Noise in High Technology Applications Including Ultrasmall Structures and Devices

DTIC Science & Technology

1991-07-15

chaos nature of 1/f noise in infrared detectors . 20. 0ISTRIBUTCN/AVAJLABi3LITY OF ABSTRACT j21. Ai3STR.ACT SECURITY fLASS.FiCATION (ZUN.’CASSIF!ED...of 1/f noise in infrared detectors . Approved .or .UnjtlC relSS* distribution unlimited AIR FrnPc COF SCIEMTIFIC RESEARCR (knSC) NOTICE OF T1SITTAL...in ultrasmall BJT’s was found to agree reasonably with the experiment. Finally, the fractional dimension of band- limited quantum 1/f noise was deter

Cost Effectiveness Analysis, A DTIC Bibliography.

DTIC Science & Technology

1980-07-01

CoSt.Nonstetionary Case. - AD-AO46 808 AD-AO0O 505 -PERSONAL AUTHOR -IKDEX-49 UNCLASSIFIED ZOW)? SAV-C"U F UNC LASS IF! ED *SCHUMACHER. WILLIAM J. OSEABERO. ERNEST ...Laboratory. Wright- Patterson AFB. envirOnmelnks wnder risk. Historically- VERT hs Ohio 45433. This work was ai calibration and been used crirnCiPally to...WRIGHT- PATTERSON AFB OH SCHOOL OF ALEXANDRIA VA SYSTEMS A𔃾D LOGISTICS A Methodology and Analysis for Cost-EffzCtive An Investigation of Changes in

Opportunities in Air Force Research and Development: Three Regional Workshop

DTIC Science & Technology

1982-08-01

BAFB DC 20332-6448 F49620-81-C-0049 J1. SUPPLEMENTARY NOTES 12a. DISTRUITION/iAVAILABLUTY STATEMENT t2A. OISTWILUTION CODE d ~ztr:L . oeasgJ 13. A1STUACT...Mewmwflm 200 waV* J ) conduct, on a regional basis, a series of three one day workshops, convening 300- 400 minority scientists from 19 states, 77...OF ABSTRACT OF REPORT OF THIS PAGE j OF ABSTRACT unc lass ified I unclass ified __ NSN 7540-01-2SSOO Stanaro Form 2" (890104 Draft) ft5VW " A" VidMS89

The Army’s Activities in Artificial Intelligence/Robotics,

DTIC Science & Technology

1982-08-27

r7 AD-,30 128 THE ARMY S ACT"IVITES AN ARTIFICIAL INTELLGENCE/ROBOT CS U) ARMY ENGINEER TOPOGRAPHIC LASS FORT RELVOIR VA R D LEIGHT 27 AUG 82 ETL-042...necessary for autonomous battlefield systems in the 1990’ s . The potential applications of AI/R systems to Army needs (’ appear to be limitless. DARCOM and...procurement. The contract statement or work had four tasks to be performed. They were: a. From Army concepts and doctrine for the 1990’ s and beyond, such as

Waterfront Damage Repair for Amphibious and Advanced Bases.

DTIC Science & Technology

1988-01-01

W -. In-h E E . EE ,. E-.. fto LI *w .- o A’., WIW~~~~~ ~ V11-11 WI 1 MI - t~ r LUnc lass if ied SECUR .’ - ASSIFICATION OF T.15 PAGE Wh n I- II...JlI.h-I 1 5 SECURITYS CL ASS ’of Ih,0 Il Naval Facilities Engineering Command Unclassified 200 Stovall Street Unclassfied ___ 5 DECLASS-7C AT70N... tangling of tether cord. 4. Must have trained crew to operate. ’ SCANNING SONAR To increase the efficiency of an underwater damage assessment survey

When expectation confounds iconic memory.

PubMed

Bachmann, Talis; Aru, Jaan

2016-10-01

In response to the methodological criticism (Bachmann & Aru, 2015) of the interpretation of their earlier experimental results (Mack, Erol, & Clarke, 2015) Mack, Erol, Clarke, and Bert (2016) presented new results that they interpret again in favor of the stance that an attention-free phenomenal iconic store does not exist. Here we once more question their conclusions. When their subjects were unexpectedly asked to report the letters instead of the post-cued circles in the 101th trial where letters were actually absent, they likely failed to see the empty display area because prior experience with letters in the preceding trials produced expectancy based illusory experience of letter-like objects. Copyright © 2016 Elsevier Inc. All rights reserved.

Systems design and analysis of the microwave radiometer spacecraft

NASA Technical Reports Server (NTRS)

Garrett, L. B.

1981-01-01

Systems design and analysis data were generated for microwave radiometer spacecraft concept using the Large Advanced Space Systems (LASS) computer aided design and analysis program. Parametric analyses were conducted for perturbations off the nominal-orbital-altitude/antenna-reflector-size and for control/propulsion system options. Optimized spacecraft mass, structural element design, and on-orbit loading data are presented. Propulsion and rigid-body control systems sensitivities to current and advanced technology are established. Spacecraft-induced and environmental effects on antenna performance (surface accuracy, defocus, and boresight off-set) are quantified and structured material frequencies and modal shapes are defined.

Simulating Rule-Based Systems

DTIC Science & Technology

1988-12-01

the number of facts. NFIRE : location of the rule status flag. NLVL: the number of levels. NRULE: the number of rules. 116 NRUN: the number of runs. PD...C-INITIALIZE THE RULE MATRIX 124 C NFIRE -4 +MAXL+MAXR NFAC-0 IL-MAXL-MINL+l IR-MAXR-MINR+ 1 DO 10 I-1,NRULE MR(I,1)=I NR( I, 2)-MINL+INT(RAN( II) *IL...NR( I, 3)-MINR+INT(RAN(II)*IR) NR( I, NFIRE )-0 10 CONTINUE-A C C-STORE THE RANDOM-ASSERTION SET IN A MATRIX C READ(8,* )NRUN, lASS DO 120 I-1,NRTJN

Finding of No Significant Impact: Construction, Operation, and Maintenance of a Solar Array United States Air Force Academy, Colorado

DTIC Science & Technology

2010-04-21

2006·EX·L, Leather , Nice! 26k mi $17,977 #B21244A 1~-8556 ACCORD EX 11)01· V6, Auto,lthr, Moon Roof. #6302A $6,988 HEUBERGER MOTORS 475-1920...ns’~fl8~\\!Tv DODGE FIT 2009·Sport Pkg, Auto, Loaded #101399A $15,988 HEUIIEIIGER MOTORS 475-1920 Hyundai • Cars SONATALTD2008· Auto, Leather ...37Sol C <:LASS 󈧌-Every Op· bon, NAV, Black/ Tan . $27,999 #G343 WHY PAY R!TAIU SMART CHOICE AUTO 641·37Sol E3502006 $31),995 #U678 Red

Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors.

PubMed

Frangioudakis, G; Garrard, J; Raddatz, K; Nadler, J L; Mitchell, T W; Schmitz-Peiffer, C

2010-09-01

Lipid-induced insulin resistance is associated with intracellular accumulation of inhibitory intermediates depending on the prevalent fatty acid (FA) species. In cultured myotubes, ceramide and phosphatidic acid (PA) mediate the effects of the saturated FA palmitate and the unsaturated FA linoleate, respectively. We hypothesized that myriocin (MYR), an inhibitor of de novo ceramide synthesis, would protect against glucose intolerance in saturated fat-fed mice, while lisofylline (LSF), a functional inhibitor of PA synthesis, would protect unsaturated fat-fed mice. Mice were fed diets enriched in saturated fat, n-6 polyunsaturated fat, or chow for 6 wk. Saline, LSF (25 mg/kg x d), or MYR (0.3 mg/kg x d) were administered by mini-pumps in the final 4 wk. Glucose homeostasis was examined by glucose tolerance test. Muscle ceramide and PA were analyzed by mass spectrometry. Expression of LASS isoforms (ceramide synthases) was evaluated by immunoblotting. Both saturated and polyunsaturated fat diets increased muscle ceramide and induced glucose intolerance. MYR and LSF reduced ceramide levels in saturated and unsaturated fat-fed mice. Both inhibitors also improved glucose tolerance in unsaturated fat-fed mice, but only LSF was effective in saturated fat-fed mice. The discrepancy between ceramide and glucose tolerance suggests these improvements may not be related directly to changes in muscle ceramide and may involve other insulin-responsive tissues. Changes in the expression of LASS1 were, however, inversely correlated with alterations in glucose tolerance. The demonstration that LSF can ameliorate glucose intolerance in vivo independent of the dietary FA type indicates it may be a novel intervention for the treatment of insulin resistance.

Aryl-modified graphene quantum dots with enhanced photoluminescence and improved pH tolerance

NASA Astrophysics Data System (ADS)

Luo, Peihui; Ji, Zhe; Li, Chun; Shi, Gaoquan

2013-07-01

Chemical modification is an important technique to modulate the chemical and optical properties of graphene quantum dots (GQDs). In this paper, we report a versatile diazonium chemistry method to graft aryl groups including phenyl, 4-carboxyphenyl, 4-sulfophenyl and 5-sulfonaphthyl to GQDs via Gomberg-Bachmann reaction. The aryl-modified GQDs are nanocrystals with lateral dimensions in the range of 2-4 nm and an average thickness lower than 1 nm. Upon chemical modification with aryl groups, the photoluminescence (PL) bands of GQDs were tuned in the range of 418 and 447 nm, and their fluorescence quantum yields (QYs) were increased for up to about 6 times. Furthermore, the aryl-modified GQDs exhibited stable PL (both intensity and peak position) in a wide pH window of 1-11. The mechanism of improving the PL properties of GQDs by aryl-modification was also discussed.Chemical modification is an important technique to modulate the chemical and optical properties of graphene quantum dots (GQDs). In this paper, we report a versatile diazonium chemistry method to graft aryl groups including phenyl, 4-carboxyphenyl, 4-sulfophenyl and 5-sulfonaphthyl to GQDs via Gomberg-Bachmann reaction. The aryl-modified GQDs are nanocrystals with lateral dimensions in the range of 2-4 nm and an average thickness lower than 1 nm. Upon chemical modification with aryl groups, the photoluminescence (PL) bands of GQDs were tuned in the range of 418 and 447 nm, and their fluorescence quantum yields (QYs) were increased for up to about 6 times. Furthermore, the aryl-modified GQDs exhibited stable PL (both intensity and peak position) in a wide pH window of 1-11. The mechanism of improving the PL properties of GQDs by aryl-modification was also discussed. Electronic supplementary information (ESI) available: Fluorescence quantum yield measurements, estimation of grafting ratio, TEM images, FTIR spectra, PL spectra and zeta potentials. See DOI: 10.1039/c3nr02156d

Using the magmatic record to constrain the growth of continental crust-The Eoarchean zircon Hf record of Greenland

NASA Astrophysics Data System (ADS)

Fisher, Christopher M.; Vervoort, Jeffrey D.

2018-04-01

Southern West Greenland contains some of the best-studied and best-preserved magmatic Eoarchean rocks on Earth, and these provide an excellent vantage point from which to view long-standing questions regarding the growth of the earliest continental crust. In order to address the questions surrounding early crustal growth and complementary mantle depletion, we present Laser Ablation Split Stream (LASS) analyses of the U-Pb and Hf isotope compositions of zircon from eleven samples of the least-altered meta-igneous rocks from the Itsaq (Amîtsoq) Gneisses of the Isukasia and Nuuk regions of southern West Greenland. This analytical technique allows a less ambiguous approach to determining the age and Hf isotope composition of complicated zircon. Results corroborate previous findings that Eoarchean zircon from the Itsaq Gneiss (∼3.85 Ga to ∼3.63 Ga) were derived from a broadly chondritic source. In contrast to the Sm-Nd whole rock isotope record for southern West Greenland, the zircon Lu-Hf isotope record provides no evidence for early mantle depletion, nor does it suggest the presence of crust older than ∼3.85 Ga in Greenland. Utilizing LASS U-Pb and Hf data from the Greenland zircons studied here, we demonstrate the importance of focusing on the magmatic (rather than detrital) zircon record to more confidently understand early crustal growth and mantle depletion. We compare the Greenland Hf isotope data with other Eoarchean magmatic complexes such as the Acasta Gneiss Complex, Nuvvuagittuq greenstone belt, and the gneissic complexes of southern Africa, and all lack zircons with suprachondritic Hf isotope compositions. In total, these data suggest only a very modest volume of crust was produced during (or survived from) the Hadean and earliest Eoarchean. There remains no record of planet-scale early Earth mantle depletion in the Hf isotope record prior to 3.8 Ga.

Duration of convergence at the Pacific-Gondwana plate margin: insights from accessory phase petrochronology of the Alpine Schist, New Zealand

NASA Astrophysics Data System (ADS)

Briggs, S. I.; Cottle, J. M.; Smit, M. A.; Arnush, N. F.

2016-12-01

The timing, duration and along-strike synchroneity of metamorphism and anataxis in the Alpine Schist of New Zealand is a matter of considerable debate. Our preliminary data indicate that metamorphism resulting in garnet growth occurred from 97 - 75 Ma, and anatectic melting occurred from 80 - 51 Ma. These events are contemporaneous with rifting of Zealandia from East Gondwana, and Tasman Sea spreading from 83 - 52 Ma. An important implication of these results is that Late Cretaceous convergence along the Zealandia segment of the Pacific-Gondwana plate margin may have persisted much later than previously thought, and that convergence and extension occurred coevally in adjacent areas. This poses the question: for how long did convergence continue along the Pacific-Gondwana plate margin during East Gondwana breakup? To fully decipher the multiple stages of the complex metamorphic history recorded in the Alpine Schist, we combine Lu-Hf garnet geochronology with U-Th/Pb and REE analyses of zircon and monazite. We use the newly developed `single-shot laser ablation split stream' (SS-LASS) analysis method to obtain depth profiles through 5-10 µm metamorphic zircon overgrowths at 100 nm depth resolution to constrain both the timing and petrological context of discrete metamorphic zircon (re-)crystallization events recorded in the Alpine Schist. We also employ high spatial resolution LASS analysis to target rare 5 - 20 µm monazite in thin section to augment garnet and zircon data. Our multi-accessory phase petrochronology approach is capable of resolving discrete short-duration thermal events, strengthening the geological interpretation of `mean' Lu-Hf garnet ages and discerning between an episodic versus a prolonged history of metamorphism. In addition, comparison with geochronology from anatectic pegmatites clarifies the temporal relationship between metamorphism and melting in the Alpine Schist, while providing direct constraints on the timing and duration of

Highlights of L011.

DTIC Science & Technology

1977-08-03

AD—A OQ 15 CALIFORNIA UN I V SANTA CRUZ INFORMATION SCIENCES FIG 9.’2 HIGHLIGHTS OF LO11.(U) ~~~ LASS ~~~~~ TR— 77—8—OO5 H MCKEEMAN EN D...EA & WORK UNIT NUMBERS Board of Studies in Information Sciences - . University of Californiav ~~~~~~~~ • I Santa Cruz, Ca1ifnrn(~ 9S~ f LL - II. C O...Office of Naval Research contract NOOO1~ —76 C O682.* .~~~~ .. 3. The Board of Studies in InforMation Sciences, UCSCe~~~~ ~~~~~ 00 ~~ ~~~~~ ifl ,’jIIfl

Energy Transfer between Post-Transition Elements & Rare Earths in Oxide & Chalcogenide Glasses.

DTIC Science & Technology

1979-08-27

Caird [13]. A calculation of reduced matrix elements of Pr3 in 20 Na O • 80 TeO2 glass [14] showed that they differ slightly from data of ref. [121... glasses Transition (lass 35 ZnO 65 TeO2 20 Na2 O 80 TeO 2 fX 106 fX 106 l.,eas 3a, a) Ia’l. faI f.me.s f al f+ I fal 3 H4 - 3 H6 1.56 1.65 1.12...Rare-Earth Doped Glasses 20. jIST HAEV CCnFn~m ,i cn,on ra e sideit If c."*Ar’ -- ~ 14-r by t?-h.c .: r Intensity parameters, radiative transition

Integrated Fiber-Optic Coupler.

DTIC Science & Technology

1987-04-01

p. 563, 1984. 1 .T.H. W. n h= n , G.M. Metze, B.- Y . Tuu ,J.C.C. Far., "A a s double-heterostructure diode lasers fabricated on a monolithic GaAs/Si...INII RAitI) R HR ( OLIlIR HR t( N ,% NOS( I D108 I R IOst\\1 tN( LASS~l1 D R 87 mm mhhh z V. 0 0- z C ,, Technical Document 1086 April 1987 Integrated...Cmeed".~) n Interated Fiber-Optic Coupler 12 PERSONAL AU1HOS) P.L Pruaal, E.R. Foesuim 139 TYPE OF RE[POR 3b, IME COVERED4 DATE OF REPORT (’r. 4#e ow S

Spatially localized motion aftereffect disappears faster from awareness when selectively attended to according to its direction.

PubMed

Murd, Carolina; Bachmann, Talis

2011-05-25

In searching for the target-afterimage patch among spatially separate alternatives of color-afterimages the target fades from awareness before its competitors (Bachmann, T., & Murd, C. (2010). Covert spatial attention in search for the location of a color-afterimage patch speeds up its decay from awareness: Introducing a method useful for the study of neural correlates of visual awareness. Vision Research 50, 1048-1053). In an analogous study presented here we show that a similar effect is obtained when a target spatial location specified according to the direction of motion aftereffect within it is searched by covert top-down attention. The adverse effect of selective attention on the duration of awareness of sensory qualiae known earlier to be present for color and periodic spatial contrast is extended also to sensory channels carrying motion information. Copyright © 2011 Elsevier Ltd. All rights reserved.

Soc Trang City Apt., Vietnam. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

DTIC Science & Technology

1971-03-25

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Short-circuiting magma differentiation from basalt straight to rhyolite?

NASA Astrophysics Data System (ADS)

Ruprecht, P.; Winslow, H.

2017-12-01

Silicic magmas are the product of varying degrees of crystal fractionation and crustal assimilation/melting. Both processes lead to differentiation that is step-wise rather than continuous for example during melt separation from a crystal mush (Dufek and Bachmann, 2010). However, differentiation is rarely efficient enough to evolve directly from a basaltic to a rhyolitic magma. At Volcán Puyehue-Cordón Caulle, Chile, the magma series is dominated by crystal fractionation where mixing trends between primitive and felsic end members in the bulk rock compositions are almost absent (e.g. P, FeO, TiO2 vs. SiO2). How effective fraction is in this magmatic system is not well-known. The 2011-12 eruption at Cordón Caulle provides new constraints that rhyolitic melts may be derived directly from a basaltic mush. Minor, but ubiquitous mafic, crystal-rich enclaves co-erupted with the predominantly rhyolitic near-aphyric magma. These enclaves are among the most primitive compositions erupted at Puyehue-Cordón Caulle and geochemically resemble closely basaltic magmas that are >10 ka old (Singer et al. 2008) and that have been identified as a parental tholeiitic mantle-derived magma (Schmidt and Jagoutz, 2017) for the Southern Andean Volcanic Zone. The vesiculated nature, the presence of a microlite-rich groundmass, and a lack of a Eu anomaly in these encalves suggest that they represent recharge magma/mush rather than sub-solidus cumulates and therefore have potentially a direct petrogenetic link to the erupted rhyolites. Our results indicate that under some conditions crystal fractionation can be very effective and the presence of rhyolitic magmas does not require an extensive polybaric plumbing system. Instead, primitive mantle-derived magmas source directly evolved magmas. In the case, of the magma system beneath Puyehue-Cordón Caulle, which had three historic rhyolitic eruptions (1921-22, 1960, 2011-12) these results raise the question whether rhyolite magma extraction

Geochronology of Zircon in Eclogite Reveals Imbrication of the Ultrahigh-Pressure Western Gneiss Region of Norway.

NASA Astrophysics Data System (ADS)

Young, D. J.; Kylander-Clark, A. R.; Root, D. B.

2014-12-01

Eclogite provides the only record of kinematic events at the deepest levels of orogens. Integrating the U-Pb geochronology and trace element chemistry of zircon in eclogite reveals the most complete view of the PTt history, yet low concentrations of uranium and zirconium and drier compositions that hinder zircon growth at peak conditions render it a challenging rocktype for this approach. The iconic Western Gneiss Region (WGR) in Norway is one of the largest terranes of deeply subducted continental rocks in the world, and contains many indicators of ultrahigh-pressure metamorphic conditions (P>2.8 GPa) that developed during the Siluro-Devonian Caledonian Orogeny. A metamorphic transition from amphibolite-facies to ultrahigh-pressure eclogite facies broadly coincides with a km-scale shear zone that underlies the majority of the WGR. A critical unknown is the timing of movement on this feature, which emplaced allochthonous units above the Baltica basement, but might also have accommodated late-orogenic exhumation of the WGR from mantle depths. We carried out laser ablation split-stream ICPMS (LASS) and selected multigrain TIMS analyses of zircons from eleven eclogites across the southern WGR, of which eight are located within or above the shear zone. LASS spots on polished grains mostly yield weakly discordant Proterozoic intrusive ages, and often minimal indication of a Caledonian (U)HP metamorphic overprint. Direct ablation into unpolished zircon reveals thin rims of Caledonian age in some cases. Overall, the dataset shows that all samples began zircon growth at approximately the same time (ca. 430-420 Ma). Eclogite from lower levels of the shear zone does not contain any dates younger than ca. 410 Ma, however, while eclogite from higher levels continued growth until ca. 400 Ma. We interpret this to result from thrusting of the WGR above cooler basement after 410 Ma, terminating new zircon crystallization within the shear zone but allowing limited further growth in

The Hall D solenoid helium refrigeration system at JLab

DOE Office of Scientific and Technical Information (OSTI.GOV)

Laverdure, Nathaniel A.; Creel, Jonathan D.; Dixon, Kelly d.

Hall D, the new Jefferson Lab experimental facility built for the 12GeV upgrade, features a LASS 1.85 m bore solenoid magnet supported by a 4.5 K helium refrigerator system. This system consists of a CTI 2800 4.5 K refrigerator cold box, three 150 hp screw compressors, helium gas management and storage, and liquid helium and nitrogen storage for stand-alone operation. The magnet interfaces with the cryo refrigeration system through an LN2-shielded distribution box and transfer line system, both designed and fabricated by JLab. The distribution box uses a thermo siphon design to respectively cool four magnet coils and shields withmore » liquid helium and nitrogen. We describe the salient design features of the cryo system and discuss our recent commissioning experience.« less

Hilbert's axiomatic method and Carnap's general axiomatics.

PubMed

Stöltzner, Michael

2015-10-01

This paper compares the axiomatic method of David Hilbert and his school with Rudolf Carnap's general axiomatics that was developed in the late 1920s, and that influenced his understanding of logic of science throughout the 1930s, when his logical pluralism developed. The distinct perspectives become visible most clearly in how Richard Baldus, along the lines of Hilbert, and Carnap and Friedrich Bachmann analyzed the axiom system of Hilbert's Foundations of Geometry—the paradigmatic example for the axiomatization of science. Whereas Hilbert's axiomatic method started from a local analysis of individual axiom systems in which the foundations of mathematics as a whole entered only when establishing the system's consistency, Carnap and his Vienna Circle colleague Hans Hahn instead advocated a global analysis of axiom systems in general. A primary goal was to evade, or formalize ex post, mathematicians' 'material' talk about axiom systems for such talk was held to be error-prone and susceptible to metaphysics. Copyright © 2015 Elsevier Ltd. All rights reserved.

No iconic memory without attention.

PubMed

Mack, Arien; Erol, Muge; Clarke, Jason; Bert, John

2016-02-01

The experiments reported extend the findings of our earlier paper, (Mack, Erol, & Clarke, 2015) and allow us to reject Bachmann and Aru's critique of our conclusion (2015) that IM requires attention. They suggested our manipulations, which diverted attention from a letter reporting task in a dual task procedure where the task-cue occurred after the array disappeared, might only have affected access to IM and not the "existence of the phenomenal experience". By further decreasing the probability of reporting letters to only 10% and adding a final trial in which the letter matrix was either completely absent or distorted, we found more than half our subjects were unaware of its absence, or distortion i.e., were inattentionally blind. We take this as powerful evidence against the existence of any phenomenal experience component of iconic memory and consistent with the view that iconic memory demands attention and that conscious perception does as well. Copyright © 2015 Elsevier Inc. All rights reserved.

Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.

PubMed

Demirkan, Ayşe; van Duijn, Cornelia M; Ugocsai, Peter; Isaacs, Aaron; Pramstaller, Peter P; Liebisch, Gerhard; Wilson, James F; Johansson, Åsa; Rudan, Igor; Aulchenko, Yurii S; Kirichenko, Anatoly V; Janssens, A Cecile J W; Jansen, Ritsert C; Gnewuch, Carsten; Domingues, Francisco S; Pattaro, Cristian; Wild, Sarah H; Jonasson, Inger; Polasek, Ozren; Zorkoltseva, Irina V; Hofman, Albert; Karssen, Lennart C; Struchalin, Maksim; Floyd, James; Igl, Wilmar; Biloglav, Zrinka; Broer, Linda; Pfeufer, Arne; Pichler, Irene; Campbell, Susan; Zaboli, Ghazal; Kolcic, Ivana; Rivadeneira, Fernando; Huffman, Jennifer; Hastie, Nicholas D; Uitterlinden, Andre; Franke, Lude; Franklin, Christopher S; Vitart, Veronique; Nelson, Christopher P; Preuss, Michael; Bis, Joshua C; O'Donnell, Christopher J; Franceschini, Nora; Witteman, Jacqueline C M; Axenovich, Tatiana; Oostra, Ben A; Meitinger, Thomas; Hicks, Andrew A; Hayward, Caroline; Wright, Alan F; Gyllensten, Ulf; Campbell, Harry; Schmitz, Gerd

2012-01-01

Phospho- and sphingolipids are crucial cellular and intracellular compounds. These lipids are required for active transport, a number of enzymatic processes, membrane formation, and cell signalling. Disruption of their metabolism leads to several diseases, with diverse neurological, psychiatric, and metabolic consequences. A large number of phospholipid and sphingolipid species can be detected and measured in human plasma. We conducted a meta-analysis of five European family-based genome-wide association studies (N = 4034) on plasma levels of 24 sphingomyelins (SPM), 9 ceramides (CER), 57 phosphatidylcholines (PC), 20 lysophosphatidylcholines (LPC), 27 phosphatidylethanolamines (PE), and 16 PE-based plasmalogens (PLPE), as well as their proportions in each major class. This effort yielded 25 genome-wide significant loci for phospholipids (smallest P-value = 9.88×10(-204)) and 10 loci for sphingolipids (smallest P-value = 3.10×10(-57)). After a correction for multiple comparisons (P-value<2.2×10(-9)), we observed four novel loci significantly associated with phospholipids (PAQR9, AGPAT1, PKD2L1, PDXDC1) and two with sphingolipids (PLD2 and APOE) explaining up to 3.1% of the variance. Further analysis of the top findings with respect to within class molar proportions uncovered three additional loci for phospholipids (PNLIPRP2, PCDH20, and ABDH3) suggesting their involvement in either fatty acid elongation/saturation processes or fatty acid specific turnover mechanisms. Among those, 14 loci (KCNH7, AGPAT1, PNLIPRP2, SYT9, FADS1-2-3, DLG2, APOA1, ELOVL2, CDK17, LIPC, PDXDC1, PLD2, LASS4, and APOE) mapped into the glycerophospholipid and 12 loci (ILKAP, ITGA9, AGPAT1, FADS1-2-3, APOA1, PCDH20, LIPC, PDXDC1, SGPP1, APOE, LASS4, and PLD2) to the sphingolipid pathways. In large meta-analyses, associations between FADS1-2-3 and carotid intima media thickness, AGPAT1 and type 2 diabetes, and APOA1 and coronary artery disease were observed. In conclusion, our

MSFC Three Point Docking Mechanism design review

NASA Technical Reports Server (NTRS)

Schaefer, Otto; Ambrosio, Anthony

1992-01-01

In the next few decades, we will be launching expensive satellites and space platforms that will require recovery for economic reasons, because of initial malfunction, servicing, repairs, or out of a concern for post lifetime debris removal. The planned availability of a Three Point Docking Mechanism (TPDM) is a positive step towards an operational satellite retrieval infrastructure. This study effort supports NASA/MSFC engineering work in developing an automated docking capability. The work was performed by the Grumman Space & Electronics Group as a concept evaluation/test for the Tumbling Satellite Retrieval Kit. Simulation of a TPDM capture was performed in Grumman's Large Amplitude Space Simulator (LASS) using mockups of both parts (the mechanism and payload). Similar TPDM simulation activities and more extensive hardware testing was performed at NASA/MSFC in the Flight Robotics Laboratory and Space Station/Space Operations Mechanism Test Bed (6-DOF Facility).

Anatomy of the left atrium for interventional electrophysiologists.

PubMed

Ho, Siew Yen; McCarthy, Karen P

2010-05-01

Increasingly, interventional procedures require accessing the left atrium from the inside of the heart as well as from the pericardial space. The right phrenic nerve running along the fibrous pericardium is close to the atrial insertion of the right superior pulmonary vein while the left phrenic nerve passes over the left atrial appendage. Posteriorly, the esophagus descends adjacent to the fibrous pericardium covering the posterior and postero-inferior walls of the left atrium. The component parts of the left atrium are reviewed with emphasis on the structure of the atrial septum, the left atrial ridge, the mitral isthmus, and the left atrial walls. Although the atrial walls are mainly smooth, pits and crevices are common in the region of the mitral isthmus and the vicinity of the os of the atrial appendage. The muscular rim around the valve of the oval fossa delimits the extent of the true atrial septum. Interatrial muscular connections exist at the septum, along Bachmann's bundle and also at the muscular sleeves of the coronary sinus and pulmonary veins. Anatomical features relevant to interventional electrophysiologists are highlighted.

Local perturbations perturb—exponentially-locally

NASA Astrophysics Data System (ADS)

De Roeck, W.; Schütz, M.

2015-06-01

We elaborate on the principle that for gapped quantum spin systems with local interaction, "local perturbations [in the Hamiltonian] perturb locally [the groundstate]." This principle was established by Bachmann et al. [Commun. Math. Phys. 309, 835-871 (2012)], relying on the "spectral flow technique" or "quasi-adiabatic continuation" [M. B. Hastings, Phys. Rev. B 69, 104431 (2004)] to obtain locality estimates with sub-exponential decay in the distance to the spatial support of the perturbation. We use ideas of Hamza et al. [J. Math. Phys. 50, 095213 (2009)] to obtain similarly a transformation between gapped eigenvectors and their perturbations that is local with exponential decay. This allows to improve locality bounds on the effect of perturbations on the low lying states in certain gapped models with a unique "bulk ground state" or "topological quantum order." We also give some estimate on the exponential decay of correlations in models with impurities where some relevant correlations decay faster than one would naively infer from the global gap of the system, as one also expects in disordered systems with a localized groundstate.

Craniofacial bone abnormalities and malocclusion in individuals with sickle cell anemia: a critical review of the literature

PubMed Central

Costa, Cyrene Piazera Silva; de Carvalho, Halinna Larissa Cruz Correia; Thomaz, Erika Bárbara Abreu Fonseca; Sousa, Soraia de Fátima Carvalho

2012-01-01

This study aims to critically review the literature in respect to craniofacial bone abnormalities and malocclusion in sickle cell anemia individuals. The Bireme and Pubmed electronic databases were searched using the following keywords: malocclusion, maxillofacial abnormalities, and Angle Class I, Class II and lass III malocclusions combined with sickle cell anemia. The search was limited to publications in English, Spanish or Portuguese with review articles and clinical cases being excluded from this study. Ten scientific publications were identified, of which three were not included as they were review articles. There was a consistent observation of orthodontic and orthopedic variations associated with sickle cell anemia, especially maxillary protrusions. However, convenience sampling, sometimes without any control group, and the lack of estimates of association and hypotheses testing undermined the possibility of causal inferences. It was concluded that despite the high frequency of craniofacial bone abnormalities and malocclusion among patients with sickle cell anemia, there is insufficient scientific proof that this disease causes malocclusion PMID:23049386

Temperature dependent mobility measurements of alkali earth ions in superfluid helium

NASA Astrophysics Data System (ADS)

Putlitz, Gisbert Zu; Baumann, I.; Foerste, M.; Jungmann, K.; Riediger, O.; Tabbert, B.; Wiebe, J.; Zühlke, C.

1998-05-01

Mobility measurements of impurity ions in superfluid helium are reported. Alkali earth ions were produced with a laser sputtering technique and were drawn inside the liquid by an electric field. The experiments were carried out in the temperature region from 1.27 up to 1.66 K. The temperature dependence of the mobility of Be^+-ions (measured here for the first time) differs from that of the other alkali earth ions Mg^+, Ca^+, Sr^+ and Ba^+, but behaves similar to that of He^+ (M. Foerste, H. Günther, O. Riediger, J. Wiebe, G. zu Putlitz, Z. Phys. B) 104, 317 (1997). Theories of Atkins (A. Atkins, Phys. Rev.) 116, 1339 (1959) and Cole (M.W. Cole, R.A. Bachmann Phys. Rev. B) 15, 1388 (1977) predict a different defect structure for He^+ and the alkali earth ions: the helium ion is assumed to form a snowball like structure whereas for the alkali earth ions a bubble structure is assumed. If the temperature dependence is a characteristic feature for the different structures, then it seems likely that the Be^+ ion builds a snowball like structure.

Free boundary resistive modes in tokamaks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huysmans, G.T.A.; Goedbloed, J.P.; Kerner, W.

1993-05-01

There exist a number of observations of magnetohydrodynamic (MHD) activity that can be related to resistive MHD modes localized near the plasma boundary. To study the stability of these modes, a free boundary description of the plasma is essential. The resistive plasma--vacuum boundary conditions have been implemented in the fully toroidal resistive spectral code CASTOR (Complex Alfven Spectrum in Toroidal Geometry) [[ital Proceedings] [ital of] [ital the] 18[ital th] [ital Conference] [ital on] [ital Controlled] [ital Fusion] [ital and] [ital Plasma] [ital Physics], Berlin, edited by P. Bachmann and D. C. Robinson (European Physical Society, Petit-Lancy, Switzerland, 1991), p. 89].more » The influence of a free boundary, as compared to a fixed boundary on the stability of low-[ital m] tearing modes, is studied. It is found that the stabilizing (toroidal) effect of a finite pressure due the plasma compression is lost in the free boundary case for modes localized near the boundary. Since the stabilization due to the favorable average curvature in combination with a pressure gradient near the boundary is small, the influence of the pressure on the stability is much less important for free boundary modes than for fixed boundary modes.« less

Fractional CO2 laser for vulvovaginal atrophy (VVA) dyspareunia relief in breast cancer survivors.

PubMed

Pieralli, Annalisa; Fallani, Maria Grazia; Becorpi, Angelamaria; Bianchi, Claudia; Corioni, Serena; Longinotti, Manuela; Tredici, Zelinda; Guaschino, Secondo

2016-10-01

The aim of this study was to evaluate the efficacy of fractional CO2 laser therapy in breast cancer survivors as a therapeutic method for vulvovaginal atrophy (VVA) dyspareunia. 50 patients (mean age 53.3 years) underwent fractional microablative CO2 laser treatment for dyspareunia in oncological menopause (mean time of menopause 6.6 years). The Gloria Bachmann's Vaginal Health Index (VHI) score was chosen as system to evaluate the presence of VVA and its improvement after the treatment. Intensity of dyspareunia was evaluated using a visual analog scale (VAS). Data indicated a significant improvement in VVA dyspareunia (p < 1.86e-22) in breast cancer survivors who had undergone 3 sessions of vaginal fractional CO2 laser treatment. Moreover, VHI scores were significantly higher 30 days post-treatment (T4) (p < 0.0001). 76 % of patients were satisfied or very satisfied with the treatment results. The majority (52 %) of patients were satisfied after a long-term follow-up (mean time 11 months). No adverse events due to fractional CO2 laser treatment occurred. The treatment with fractionated CO2 laser appeared to be a feasible and effective treatment for VVA dyspareunia in breast cancer survivors with contraindications to hormonal treatments.

Reductive electrografting of benzene (p-bisdiazonium hexafluorophosphate): a simple and effective protocol for creating diazonium-functionalized thin films.

PubMed

Marshall, Nicholas; Locklin, Jason

2011-11-01

In this Article, we describe a protocol for surface functionalization of benzenediazonium hexafluorophosphate monolayers by in situ electrochemical reduction of bis(benzenediazonium) hexafluorophosphate. Due to the considerable difference in potential between the first and second reduction of this species, it is possible to form a high density of surface-bound diazonium groups by use of a mild potential which selectively reduces only one diazonium group per ring. The resulting diazonium-containing monolayer reacts readily with solutions of electron-rich aromatic compounds. The reaction with ferrocene produces a dense (2.7 × 10(-10) mol/cm(2)) ferrocene-containing monolayer through a Gomberg-Bachmann type arylation. The resulting ferrocene group exhibits relatively rapid electron transfer to the electrode due to the conjugated linker layer as measured by alternating current voltammetry (ACV) and cyclic voltammetry. Aromatic systems with π-donor substitutents (N,N-dimethylaniline, N,N,N',N'-tetramethyldiaminobenzophenone, and hydroquinone) react through an azo-coupling to form monolayers linked to the surface through an azobenzene moiety. The redox properties of these electron-rich species tethered to the surface were observed and quantified using cyclic voltammetry. This simple and versatile functionalization procedure has a wide variety of potential applications in surface science and materials research.

Multiple New Loci Associated with Kidney Function and Chronic Kidney Disease: The CKDGen consortium

PubMed Central

Köttgen, Anna; Pattaro, Cristian; Böger, Carsten A.; Fuchsberger, Christian; Olden, Matthias; Glazer, Nicole L.; Parsa, Afshin; Gao, Xiaoyi; Yang, Qiong; Smith, Albert V.; O’Connell, Jeffrey R.; Li, Man; Schmidt, Helena; Tanaka, Toshiko; Isaacs, Aaron; Ketkar, Shamika; Hwang, Shih-Jen; Johnson, Andrew D.; Dehghan, Abbas; Teumer, Alexander; Paré, Guillaume; Atkinson, Elizabeth J.; Zeller, Tanja; Lohman, Kurt; Cornelis, Marilyn C.; Probst-Hensch, Nicole M.; Kronenberg, Florian; Tönjes, Anke; Hayward, Caroline; Aspelund, Thor; Eiriksdottir, Gudny; Launer, Lenore; Harris, Tamara B.; Rapmersaud, Evadnie; Mitchell, Braxton D.; Boerwinkle, Eric; Struchalin, Maksim; Cavalieri, Margherita; Singleton, Andrew; Giallauria, Francesco; Metter, Jeffery; de Boer, Ian; Haritunians, Talin; Lumley, Thomas; Siscovick, David; Psaty, Bruce M.; Zillikens, M. Carola; Oostra, Ben A.; Feitosa, Mary; Province, Michael; Levy, Daniel; de Andrade, Mariza; Turner, Stephen T.; Schillert, Arne; Ziegler, Andreas; Wild, Philipp S.; Schnabel, Renate B.; Wilde, Sandra; Muenzel, Thomas F.; Leak, Tennille S; Illig, Thomas; Klopp, Norman; Meisinger, Christa; Wichmann, H.-Erich; Koenig, Wolfgang; Zgaga, Lina; Zemunik, Tatijana; Kolcic, Ivana; Minelli, Cosetta; Hu, Frank B.; Johansson, Åsa; Igl, Wilmar; Zaboli, Ghazal; Wild, Sarah H; Wright, Alan F; Campbell, Harry; Ellinghaus, David; Schreiber, Stefan; Aulchenko, Yurii S; Rivadeneira, Fernando; Uitterlinden, Andre G; Hofman, Albert; Imboden, Medea; Nitsch, Dorothea; Brandstätter, Anita; Kollerits, Barbara; Kedenko, Lyudmyla; Mägi, Reedik; Stumvoll, Michael; Kovacs, Peter; Boban, Mladen; Campbell, Susan; Endlich, Karlhans; Völzke, Henry; Kroemer, Heyo K.; Nauck, Matthias; Völker, Uwe; Polasek, Ozren; Vitart, Veronique; Badola, Sunita; Parker, Alexander N.; Ridker, Paul M.; Kardia, Sharon L. R.; Blankenberg, Stefan; Liu, Yongmei; Curhan, Gary C.; Franke, Andre; Rochat, Thierry; Paulweber, Bernhard; Prokopenko, Inga; Wang, Wei; Gudnason, Vilmundur; Shuldiner, Alan R.; Coresh, Josef; Schmidt, Reinhold; Ferrucci, Luigi; Shlipak, Michael G.; van Duijn, Cornelia M.; Borecki, Ingrid; Krämer, Bernhard K.; Rudan, Igor; Gyllensten, Ulf; Wilson, James F.; Witteman, Jacqueline C.; Pramstaller, Peter P.; Rettig, Rainer; Hastie, Nick; Chasman, Daniel I.; Kao, W. H.; Heid, Iris M.; Fox, Caroline S.

2010-01-01

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 Caucasian individuals from 20 population-based studies to identify new susceptibility loci for reduced renal function, estimated by serum creatinine (eGFRcrea), cystatin C (eGFRcys), and CKD (eGFRcrea <60 ml/min/1.73m2; n = 5,807 CKD cases). Follow-up of the 23 genome-wide significant loci (p<5×10−8) in 22,982 replication samples identified 13 novel loci for renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2, and SLC7A9) and 7 creatinine production and secretion loci (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72, BCAS3). These results further our understanding of biologic mechanisms of kidney function by identifying loci potentially influencing nephrogenesis, podocyte function, angiogenesis, solute transport, and metabolic functions of the kidney. PMID:20383146

Testing Strategies and Methodologies for the Max Launch Abort System

NASA Technical Reports Server (NTRS)

Schaible, Dawn M.; Yuchnovicz, Daniel E.

2011-01-01

The National Aeronautics and Space Administration (NASA) Engineering and Safety Center (NESC) was tasked to develop an alternate, tower-less launch abort system (LAS) as risk mitigation for the Orion Project. The successful pad abort flight demonstration test in July 2009 of the "Max" launch abort system (MLAS) provided data critical to the design of future LASs, while demonstrating the Agency s ability to rapidly design, build and fly full-scale hardware at minimal cost in a "virtual" work environment. Limited funding and an aggressive schedule presented a challenge for testing of the complex MLAS system. The successful pad abort flight demonstration test was attributed to the project s systems engineering and integration process, which included: a concise definition of, and an adherence to, flight test objectives; a solid operational concept; well defined performance requirements, and a test program tailored to reducing the highest flight test risks. The testing ranged from wind tunnel validation of computational fluid dynamic simulations to component ground tests of the highest risk subsystems. This paper provides an overview of the testing/risk management approach and methodologies used to understand and reduce the areas of highest risk - resulting in a successful flight demonstration test.

Developments in Laser-Ablation Split-Stream Petrochronology

NASA Astrophysics Data System (ADS)

Kylander-Clark, Andrew R.

2017-04-01

One of the biggest challenges in assessing the timing and rates of petrogenesis and deformation is having the ability to match the age of a dated mineral to the conditions at which that mineral grew. This is especially challenging for high-temperature chonometers that can grow and remain stable over a wide range of pressures and temperatures. The development of the laser-ablation split-stream method has afforded the ability to rapidly aquire chemical and chronologic data that are directly linked; as such, timing and rates of processes are better constrained than before. Several examples are given within: 1) Zircon and monazite from a single, coesite-bearing sample from the Western Gneiss Region in western Norway record the entire 30+ Myr history of metamorphism during Caledonian orogenesis, from intial burial, through ultrahigh-pressure (UHP) conditions, and back to crustal levels. Early monazite ( 425 Ma) contains low concentrations of Sr and HREE, consistent with plagioclase and garnet stability during prograde metamorphism. 420-400 Ma ages from monazite (high Sr, increased Eu/Eu*, low HREE) and zircon (increased Eu/Eu*, low HREE) indicate the timing of HP conditions, and monazite with low Sr and high HREE indicates the breakdown of omphacite and garnet at 390 Ma. 2) Titanite is becoming more widely used as chronometer, primarly because laser ablation has made analysis more feasible. Nevertheless, dates produced from titanite can be difficult to interpret because titanite may alter more easily than zircon and monazite. LASS analyses of titanite, combined with X-ray maps and backscattered electron images provide insight into processes involved in growth, recrystallization and dissolution/reprecipitation, and allow us to better interpret ages and the geologic process that they represent. This study presents recrystallized titanite from metamorphic terranes as well as ocillatory-zoned titanite from igneous rocks, and suggests some possible processes that explain the

Comparative chronology of Archean HT/UHT crustal metamorphism

NASA Astrophysics Data System (ADS)

Caddick, Mark; Dragovic, Besim; Guevara, Victor

2017-04-01

Attainment of high crustal heat fluxes and consequent partial melting is critical to the stabilization of continental roots. Understanding the processes and timescales behind partial melting of continental crust in the Archean is thus paramount for understanding Archean tectonic modes and how stable cratons formed. High-temperature (HT) to ultrahigh-temperature (UHT) metamorphic rocks can record evidence for dynamic processes that result in advective heat fluxes and a substantial deviation from normal crustal geothermal gradients. Examination of the pressure-temperature conditions and timescales of HT/UHT metamorphism is thus essential to understanding the tectonic processes behind extreme crust heat fluxes and the formation of stable cratonic crust. Here, utilizing both traditional and nontraditional petrologic and geochronologic techniques, we compare the pressure-temperature-time paths of two Neoarchean terranes: the eastern Beartooth Mountains of the Wyoming Craton and the Pikwitonei Granulite Domain of the Superior Province. The Beartooth Mountains of Montana, USA, expose Archean rocks of the Wyoming Craton that are dominated by an ˜2.8 Ga calc-alkaline granitoid batholith known as the Long Lake Magmatic Complex (LLMC). The LLMC contains widespread, up to km-scale metasedimentary roof pendants, with ID-TIMS Sm-Nd garnet geochronology and laser ablation split stream (LASS) monazite geochronology suggesting that metamorphism occurred almost 100 Ma after entrainment by the LLMC [1]. Phase equilibria modeling and Zr-in-rutile thermometry constrain peak pressures and temperatures of ˜6-7 kbar and ˜780-800˚ C. Major element diffusion modeling of garnet suggest that granulite-facies temperatures were only maintained for a short duration, < 2 Ma. In contrast, the Pikwitonei Granulite Domain consists of >150,000 km2 of high-grade metamorphic rocks situated in the NW Superior Province. Phase equilibria modeling and trace element thermometry constrain peak

About the specialized myocardial conducting tissue.

PubMed

de Micheli Serra, Alfredo; Iturralde Torres, Pedro; Aranda Fraustro, Alberto

2013-01-01

The chronological succession of discoveries on the location and structure of the atrio-ventricular conducting system are described. The starting point of this system is located in the sinus atrial node, identified by the English scientists A. Keith and M. W. Flack in 1907. The atrioventricular conducting system was pointed out by the Swiss physician Wilhelm His Jr. in 1893. The atrioventricular node (AV) was first identified by the Japanese pathologist Sumao Tawara and his German professor Ludwig Aschoff in 1906. Likewise the structure and routes of the three internodal bundles are described. These bundles include: Bachmann's bundle (1916) connecting the right with the left atrium and the AV node; the middle Wenckebach's bundle (1910) and the posterior or Thörel's bundle (1910), extending from the region of the sinus atrial node towards the posterior margin of the AV node. Lastly, the ventricular left and right conduction systems are detailed. These include the main trunk and their peripheral subdivisions with respective networks. Regarding the controversial existence of the left middle subdivision, it can exist in animal and human hearts. Nevertheless, an intermediate left septal network of specialized fibers seems to act as a functional equivalent of this subdivision. Copyright © 2012 Instituto Nacional de Cardiología Ignacio Chávez. Published by Masson Doyma México S.A. All rights reserved.

Modeling the excitation of global Alfven modes by an external antenna in the Joint European Torus (JET)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Huysmans, G.T.A.; Kerner, W.; Borba, D.

1995-05-01

The active excitation of global Alfven modes using the saddle coils in the Joint European Torus (JET) [{ital Plasma} {ital Physics} {ital and} {ital Controlled} {ital Nuclear} {ital Fusion} {ital Research} 1984, Proceedings of the 10th International Conference, London (International Atomic Energy Agency, Vienna, 1985), Vol. 1, p. 11] as the external antenna, will provide information on the damping of global modes without the need to drive the modes unstable. For the modeling of the Alfven mode excitation, the toroidal resistive magnetohydrodynamics (MHD) code CASTOR (Complex Alfven Spectrum in TORoidal geometry) [18{ital th} {ital EPS} {ital Conference} {ital On} {italmore » Controlled} {ital Fusion} {ital and} {ital Plasma} {ital Physics}, Berlin, 1991, edited by P. Bachmann and D. C. Robinson (The European Physical Society, Petit-Lancy, 1991), Vol. 15, Part IV, p. 89] has been extended to calculate the response to an external antenna. The excitation of a high-performance, high beta JET discharge is studied numerically. In particular, the influence of a finite pressure is investigated. Weakly damped low-{ital n} global modes do exist in the gaps in the continuous spectrum at high beta. A pressure-driven global mode is found due to the interaction of Alfven and slow modes. Its frequency scales solely with the plasma temperature, not like a pure Alfven mode with a density and magnetic field.« less

New Insights on 216 Kleopatra Based on Images Collected with the SPHERE Extreme AO System

NASA Astrophysics Data System (ADS)

Marchis, F.; Vernazza, P.; Hanus, J.; Marsset, M.; Yang, B.; Carry, B.; Santana-Ros, T.; Birlan, M.

2017-12-01

ESO allocated to our Large Asteroid Survey with SPHERE (LASS) program 152 hours of observations over four semesters (PI: Pierre Vernazza, run ID: 199.C-0074) to carry out disk-resolved images of 38 large (D≥100 km) main-belt asteroids (sampling the four main compositional classes) at high angular- resolution with VLT/SPHERE throughout their rotation in order to derive their 3-D shape, the size distribution of the largest craters, and their density. Here we focus on the analysis of SPHERE data taken in July 2017 of the triple asteroid (216) Kleopatra. Two tiny moons (3 & 5 km diameter) were discovered in September 2008 around the large (equivalent radius 67.5±2.9 km) M-type asteroid orbiting very close to the irregularly shaped primary at 300 and 700 km respectively (Descamps et al. 2010). With these additional data, our goals are i) to refine the average density of this interesting M-type asteroid ii) estimate its interior structure by detecting precession effects between the satellites iii) detect the presence of an additional moon which was suspected in W.M. Keck AO observation taken back in 2008. We will present this new data set, their analysis and new conclusion on the origins and formation of this asteroid.

Data compressor designed to improve recognition of magnetic phases

NASA Astrophysics Data System (ADS)

Vogel, E. E.; Saravia, G.; Cortez, L. V.

2012-02-01

Data compressors available in the web have been used to determine magnetic phases for two-dimensional (2D) systems [E. Vogel, G. Saravia, F. Bachmann, B. Fierro, J. Fischer, Phase transitions in Edwards-Anderson model by means of information theory, Physica A 388 2009 4075-4082]. In the present work, we push this line forward along four different directions. First, the compressor itself: we design a new data compressor, named wlzip, optimized for the recognition of information having physical (or scientific) information instead of the random digital information usually compressed. Second, for the first time we extend the data compression analysis to the 3D Ising ferromagnetic model using wlzip. Third, we discuss the tuning possibilities of wlzip in terms of the number of digits considered in the compression to yield maximum definition; in this way, the transition temperature of both 2D and 3D Ising ferromagnets can be reported with very good resolution. Fourth, the extension of the time window through which the data file is actually compressed is also considered to get optimum accuracy. The paper is focused on the new compressor, its algorithm in general and the way to apply it. Advantages and disadvantages of wlzip are discussed. Toward the end, we mention other possible applications of this technique to recognize stable and unstable regimes in the evolution of variables in meteorology (such as pollution content or atmospheric pressure), biology (blood pressure) and econophysics (prices of the stock market).

Antiarrhythmic properties of atrial pacing.

PubMed

Kliś, Magdalena; Sławuta, Agnieszka; Gajek, Jacek

2017-01-01

Bradycardia, atrial stretch and dilatation, autonomic nervous system disorders, and the presence of triggers such as atrial premature contractions, are factors which predispose a person to paroxysmal AF. Atrial pacing not only eliminates bradycardia but also prevents atrial premature contractions and dispersion of refractoriness, which are a substrate for atrial fibrillation. As the prolonged duration of atrial activation during pacing, especially from locations changing the physiological pattern of this activation (right atrium lateral wall, right atrium appendage), negatively influences both a mechanical and an electrical function of the atria, the atrial pacing site affects an atrial arrhythmogenesis. A conventional atrial lead location in the right atrium appendage causes non-physiological activation propagation, resulting in a prolongation of the activation time of both atria. This location is optimal according to a passive fixation of the atrial lead but the available contemporary active fixation leads could potentially be located in any area of the atrium. There is growing evidence of the benefit of pacing, imitating the physiological propagation of impulses within the atria. It seems that the Bachmann's bundle pacing is the best pacing site within the atria, not only positively influencing the atrial mechanical function but also best fulfilling the so-called atrial resynchronization function, in particular in patients with interatrial conduction delay. It can be effectively achieved using only one atrial electrode, and the slight shortening of atrioventricular conduction provides an additional benefit of this atrial pacing site.

What do Seniors Remember from Freshman Physics?

NASA Astrophysics Data System (ADS)

Barrantes, Analia; Pawl, Andrew; Pritchard, David E.

2009-11-01

We have given a group of 56 MIT seniors who took mechanics as freshmen a written test similar to the final exam they took in their freshman course, plus the Mechanics Baseline Test (MBT) and Colorado Learning Attitudes about Science Survey (C-LASS) standard instruments. Students in majors unrelated to physics scored 60% lower on the written analytic part of the final than they did as freshmen. The mean score of all students on conceptual multiple choice questions included on the final also declined by about 60% relative to the scores of freshmen. The mean score of all participants on the MBT was insignificantly changed from the posttest taken as freshmen. More specifically, however, the students' performance on 9 of the 26 MBT items (with 6 of the 9 involving graphical kinematics) represents a gain over their freshman pretest score (a normalized gain of about 70%, double the gain achieved in the freshman course alone), while their performance on the remaining 17 questions is best characterized as a loss of approximately 50% of the material learned in the freshman course. Attitudinal survey results indicate that almost half the seniors feel the specific mechanics course content is unlikely to be useful to them, a significant majority (75-85%) feel that physics does teach valuable skills, and an overwhelming majority believe that mechanics should remain a required course at MIT.

What do Seniors Remember from Freshman Physics?

NASA Astrophysics Data System (ADS)

Barrantes, Analia; Pawl, Andrew; Pritchard, David E.

2009-10-01

We have given a group of 56 MIT seniors who took mechanics as freshmen a written test similar to the final exam they took in their freshman course, plus the MBT and C-LASS standard instruments. Students in majors unrelated to physics scored 60% lower on the written analytic part of the final than they did as freshmen. The mean score of all students on conceptual multiple choice questions included on the final declined by approximately 50% relative to the scores of freshmen. The mean score of all participants on the MBT was insignificantly changed from the posttest taken as freshmen. More specifically, however, the students' performance on 9 of the 26 MBT items (with 6 of the 9 involving graphical kinematics) represents a gain over their freshman pretest score (a normalized gain of about 70%, double the gain achieved in the freshman course alone), while their performance on the remaining 17 questions is best characterized as a loss of approximately 50% of the material learned in the freshman course. Attitudinal survey results indicate that almost half the seniors feel the specific mechanics course content is unlikely to be useful to them, a significant majority (75-85%) feel that physics does teach valuable skills, and an overwhelming majority believe that mechanics should remain a required course at MIT.

Liquid Engine Design: Effect of Chamber Dimensions on Specific Impulse

NASA Technical Reports Server (NTRS)

Hoggard, Lindsay; Leahy, Joe

2009-01-01

Which assumption of combustion chemistry - frozen or equilibrium - should be used in the prediction of liquid rocket engine performance calculations? Can a correlation be developed for this? A literature search using the LaSSe tool, an online repository of old rocket data and reports, was completed. Test results of NTO/Aerozine-50 and Lox/LH2 subscale and full-scale injector and combustion chamber test results were found and studied for this task. NASA code, Chemical Equilibrium with Applications (CEA) was used to predict engine performance using both chemistry assumptions, defined here. Frozen- composition remains frozen during expansion through the nozzle. Equilibrium- instantaneous chemical equilibrium during nozzle expansion. Chamber parameters were varied to understand what dimensions drive chamber C* and Isp. Contraction Ratio is the ratio of the nozzle throat area to the area of the chamber. L is the length of the chamber. Characteristic chamber length, L*, is the length that the chamber would be if it were a straight tube and had no converging nozzle. Goal: Develop a qualitative and quantitative correlation for performance parameters - Specific Impulse (Isp) and Characteristic Velocity (C*) - as a function of one or more chamber dimensions - Contraction Ratio (CR), Chamber Length (L ) and/or Characteristic Chamber Length (L*). Determine if chamber dimensions can be correlated to frozen or equilibrium chemistry.

A platform for European CMOS image sensors for space applications

NASA Astrophysics Data System (ADS)

Minoglou, K.; San Segundo Bello, D.; Sabuncuoglu Tezcan, D.; Haspeslagh, L.; Van Olmen, J.; Merry, B.; Cavaco, C.; Mazzamuto, F.; Toqué-Trésonne, I.; Moirin, R.; Brouwer, M.; Toccafondi, M.; Preti, G.; Rosmeulen, M.; De Moor, P.

2017-11-01

Both ESA and the EC have identified the need for a supply chain of CMOS imagers for space applications which uses solely European sources. An essential requirement on this supply chain is the platformization of the process modules, in particular when it comes to very specific processing steps, such as those required for the manufacturing of backside illuminated image sensors. This is the goal of the European (EC/FP7/SPACE) funded project EUROCIS. All EUROCIS partners have excellent know-how and track record in the expertise fields required. Imec has been leading the imager chip design and the front side and backside processing. LASSE, as a major player in the laser annealing supplier sector, has been focusing on the optimization of the process related to the backside passivation of the image sensors. TNO, known worldwide as a top developer of instruments for scientific research, including space research and sensors for satellites, has contributed in the domain of optical layers for space instruments and optimized antireflective coatings. Finally, Selex ES, as a world-wide leader for manufacturing instruments with expertise in various space missions and programs, has defined the image sensor specifications and is taking care of the final device characterization. In this paper, an overview of the process flow, the results on test structures and imagers processed using this platform will be presented.

Influence of atrial substrate on local capture induced by rapid pacing of atrial fibrillation.

PubMed

Rusu, Alexandru; Jacquemet, Vincent; Vesin, Jean-Marc; Virag, Nathalie

2014-05-01

Preliminary studies showed that the septum area was the only location allowing local capture of both the atria during rapid pacing of atrial fibrillation (AF) from a single site. The present model-based study investigated the influence of atrial substrate on the ability to capture AF when pacing the septum. Three biophysical models of AF with an identical anatomy from human atria but with different AF substrates were used: (i) AF based on multiple wavelets, (ii) AF based on heterogeneities in vagal activation, (iii) AF based on heterogeneities in repolarization. A fourth anatomical model without Bachmann's bundle (BB) was also implemented. Rapid pacing was applied from the septum at pacing cycle lengths in the range of 50-100% of AF cycle length. Local capture was automatically assessed with 24 pairs of electrodes evenly distributed on the atrial surface. The results were averaged over 16 AF simulations. In the homogeneous substrate, AF capture could reach 80% of the atrial surface. Heterogeneities degraded the ability to capture during AF. In the vagal substrate, the capture tended to be more regular and the degradation of the capture was not directly related to the spatial extent of the heterogeneities. In the third substrate, heterogeneities induced wave anchorings and wavebreaks even in areas close to the pacing site, with a more dramatic effect on AF capture. Finally, BB did not significantly affect the ability to capture. Atrial fibrillation substrate had a significant effect on rapid pacing outcomes. The response to therapeutic pacing may therefore be specific to each patient.

Origin and pharmacological response of atrial tachyarrhythmias induced by activation of mediastinal nerves in canines.

PubMed

Armour, J Andrew; Richer, Louis-Philippe; Pagé, Pierre; Vinet, Alain; Kus, Teresa; Vermeulen, Michel; Nadeau, Réginald; Cardinal, René

2005-03-31

We sought to determine the sites of origin of atrial tachyarrhythmias induced by activating mediastinal nerves, as well as the response of such arrhythmias to autonomic modulation. Under general anaesthesia, atrioventricular block was induced after thoracotomy in 19 canines. Brief trains of 5 electrical stimuli were delivered to right-sided mediastinal nerves during the atrial refractory period. Unipolar electrograms were recorded from 191 right and left atrial epicardial sites under several conditions, i.e. (i) with intact nervous systems and following (ii) acute decentralization of the intrathoracic nervous system or administration of (iii) atropine, (iv) timolol, (v) hexamethonium. Concomitant right atrial endocardial mapping was performed in 7 of these dogs. Mediastinal nerve stimulation consistently initiated bradycardia followed by atrial tachyarrhythmias. In the initial tachyarrhythmia beats, early epicardial breakthroughs were identified in the right atrial free wall (28/50 episodes) or Bachmann bundle region (22/50), which corresponded to endocardial sites of origin associated with the right atrial subsidiary pacemaker complex, i.e. the crista terminalis and dorsal locations including the right atrial aspect of the interatrial septum. Neuronally induced responses were eliminated by atropine, modified by timolol and unaffected by acute neuronal decentralization. After hexamethonium, responses to extra-pericardial but not intra-pericardial nerve stimulation were eliminated. It is concluded that concomitant activation of cholinergic and adrenergic efferent intrinsic cardiac neurons induced by right-sided efferent neuronal stimulation initiates atrial tachyarrhythmias that originate from foci anatomically related to the right atrial pacemaker complex and tissues underlying major atrial ganglionated plexuses.

Insights into new-onset atrial fibrillation following open heart surgery and implications for type II atrial flutter.

PubMed

Sadrpour, Shervin A; Srinivasan, Deepa; Bhimani, Ashish A; Lee, Seungyup; Ryu, Kyungmoo; Cakulev, Ivan; Khrestian, Celeen M; Markowitz, Alan H; Waldo, Albert L; Sahadevan, Jayakumar

2015-12-01

Postoperative atrial fibrillation (POAF), new-onset AF after open heart surgery (OHS), is thought to be related to pericarditis. Based on AF studies in the canine sterile pericarditis model, we hypothesized that POAF in patients after OHS may be associated with a rapid, regular rhythm in the left atrium (LA), suggestive of an LA driver maintaining AF. The aim of this study was to test the hypothesis that in patients with POAF, atrial electrograms (AEGs) recorded from at least one of the two carefully selected LA sites would manifest a rapid, regular rhythm with AEGs of short cycle length (CL) and constant morphology, but a selected right atrial (RA) site would manifest AEGs with irregular CLs and variable morphology. In 44 patients undergoing OHS, AEGs recorded from the epicardial surface of the RA, the LA portion of Bachmann's bundle, and the posterior LA during sustained AF were analysed for regularity of CL and morphology. Sustained AF occurred in 15 of 44 patients. Atrial electrograms were recorded in 11 of 15 patients; 8 of 11 had rapid, regular activation with constant morphology recorded from at least one LA site; no regular AEG sites were present in 3 of 11 patients. Atrial electrograms recorded during sustained POAF frequently demonstrated rapid, regular activation in at least one LA site, consistent with a driver maintaining AF. Published by Oxford University Press on behalf of the European Society of Cardiology 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Clinical Relevance of Ceramide Metabolism in the Pathogenesis of Human Head and Neck Squamous Cell Carcinoma (HNSCC): Attenuation of C18-ceramide in HNSCC Tumors Correlates with Lymphovascular Invasion and Nodal Metastasis

PubMed Central

Karahatay, Serdar; Thomas, Kesha; Koybasi, Serap; Senkal, Can E.; ElOjeimy, Saeed; Liu, Xiang; Bielawski, Jacek; Day, Terry A.; Boyd Gillespie, M; Sinha, Debajyoti; Norris, James S.; Hannun, Yusuf A.; Ogretmen, Besim

2007-01-01

It has been documented previously that defects in the generation of C18-ceramide, a product of ceramide synthase 1 (CerS1), also known as longevity assurance gene 1 (hLASS1), play important roles in the pathogenesis and/or progression of HNSCC. However, whether altered levels of ceramide generation in HNSCC tumors have any clinical relevance remains unknown. In this study, the levels of endogenous ceramides were measured in tumor tissues of 45 HNSCC patients as compared to their normal tissues using high-pressure liquid chromatography/mass spectrometry (LC/MS), and then possible link between ceramide levels and the clinical parameters of HNSCC were examined. The data showed that the levels of C16-, C24-, C24:1-ceramide were significantly elevated in the majority of tumor tissues compared to their normal tissues, while the levels of only C18-ceramide were significantly decreased in HNSCC tumors, especially in tumor tissues of male patients. Importantly, it was also shown here that decreased C18-ceramide levels in HNSCC tumor tissues were significantly associated with the higher incidences of lymphovascular invasion, and pathologic nodal metastasis. Importantly, attenuation of C18-ceramide was also positively linked to the higher overall stages of the primary HNSCC tumors. Therefore, these data suggest, for the first time, that the defects in the generation/accumulation of C18-ceramide might have important clinical roles in HNSCC, especially in lymphovascular invasion and nodal disease. PMID:17619081

Reconnaissance geologic map and mineral resource potential of the Gearhart Mountain Wilderness and Roadless Area (6225), Lake and Klamath counties, Oregon

USGS Publications Warehouse

Walker, George W.; Ridenour, James

1982-01-01

The Gearhart Mountain Wilderness, Lake and Klamath Counties, Oreg., is devoid of mines and mineral prospects and there are no known mining claims within the area. Furthermore, the results of this mineral appraisal indicate that there is little likelihood that commercial deposits of metallic minerals will be found in the area. Commercial uranium deposits, like those at the White King and Lucky Lass mines about 16 mi (~25 km) to the southeast of the wilderness, and deposits of mercury, like those south-southeast of the wilderness, are not likely to be found within the wilderness, even though all of these areas are characterized by middle and late Cenozoic intrusive and extrusive volcanic rocks. Rock of low commercial value for construction purposes is present, but better and more accessible deposits are present in adjacent regions. There is no evidence to indicate that mineral fuels are present in the area. Higher than normal heat floe characterizes the region containing Gerheart Mountain, indicating that it may have some, as yet undefined, potential for the development of geothermal energy. Data are not available to determine whether this higher than normal heat flow is meaningful in terms of a potential energy source or as a guide to possible future exploration; lack of thermal springs or other evidence of localized geothermal anomalies within the Gerhart Mountain suggest, however, that the potential for the development of geothermal energy is probably low.

Usefulness of ventricular endocardial electric reconstruction from body surface potential maps to noninvasively localize ventricular ectopic activity in patients

NASA Astrophysics Data System (ADS)

Lai, Dakun; Sun, Jian; Li, Yigang; He, Bin

2013-06-01

As radio frequency (RF) catheter ablation becomes increasingly prevalent in the management of ventricular arrhythmia in patients, an accurate and rapid determination of the arrhythmogenic site is of important clinical interest. The aim of this study was to test the hypothesis that the inversely reconstructed ventricular endocardial current density distribution from body surface potential maps (BSPMs) can localize the regions critical for maintenance of a ventricular ectopic activity. Patients with isolated and monomorphic premature ventricular contractions (PVCs) were investigated by noninvasive BSPMs and subsequent invasive catheter mapping and ablation. Equivalent current density (CD) reconstruction (CDR) during symptomatic PVCs was obtained on the endocardial ventricular surface in six patients (four men, two women, years 23-77), and the origin of the spontaneous ectopic activity was localized at the location of the maximum CD value. Compared with the last (successful) ablation site (LAS), the mean and standard deviation of localization error of the CDR approach were 13.8 and 1.3 mm, respectively. In comparison, the distance between the LASs and the estimated locations of an equivalent single moving dipole in the heart was 25.5 ± 5.5 mm. The obtained CD distribution of activated sources extending from the catheter ablation site also showed a high consistency with the invasively recorded electroanatomical maps. The noninvasively reconstructed endocardial CD distribution is suitable to predict a region of interest containing or close to arrhythmia source, which may have the potential to guide RF catheter ablation.

2007 Critical Review Discussion -- Will the circle be unbroken: a history of the U.S. national ambient air quality standards

DOE Office of Scientific and Technical Information (OSTI.GOV)

Judith C. Chow; John G. Watson; Howard J. Feldman

In the review, John D. Bachmann traces the regulatory history of U.S. air pollution from the beginning of the 20th century to the present. The review divides this progress into four segments: (1) 1900-1970, from smoke abatement to federal involvement and the establishment of air quality management (AQM) in the 1970 Clean Air Act (CAA); (2) 1971-1976, when the first National Ambient Air Quality Standards (NAAQS) were promulgated and implemented; (3) 1977-1993, which included the first NAAQS revisions, major CAA amendments, and the evolution of AQM; and (4) 1993-2006, the second and third waves of NAAQS revisions and their implementationmore » in the context of the 1990 CAA amendments. A discussant's commentary does not necessarily reflect the position of his or her respective organization. This Critical Review Discussion was compiled from written submissions and presentation transcripts. The invited discussants are as follows: Mr. Howard J. Feldman, director of regulatory and scientific affairs for the American Petroleum Institute; Ms. Janice E. Nolen, assistant vice president of national policy and advocacy for the American Lung Association; Dr. Barry Wallerstein, executive officer at the South Coast Air Quality Management District; Dr. John G. Watson, research professor in the Division of Atmospheric Sciences at the Desert Research Institute; Dr. George M. Hidy of Envair/Aerochem; Dr. Paul J. Lioy, Department of Environmental and Occupational Medicine; Robert Wood Johnson Medical School, University of Medicine and Dentistry, New Jersey; Dr. Herbert McKee, environmental consultant; Mr. David Mobley of the Atmospheric Modeling Division of the EPA's Office of Research and Development; and Mr. Keith Baugues, P.E., of air services for KERAMIDA Environmental. 127 refs.« less

Educational and emotional health outcomes in adolescence following maltreatment in early childhood: A population-based study of protective factors.

PubMed

Khambati, Nisreen; Mahedy, Liam; Heron, Jon; Emond, Alan

2018-07-01

Although childhood maltreatment is associated with long-term impairment, some children function well despite this adversity. This study aimed to identify the key protective factors for good educational attainment and positive emotional health in adolescents who experienced maltreatment in early childhood. Data were analyzed from the Avon Longitudinal Study of Parents and Children, a large UK prospective cohort study. The sample was defined by maternally reported exposure to physical or emotional maltreatment by a parent prior to 5 years. 1118 (8.0%) children were emotionally maltreated and 375 (2.7%) were physically maltreated before the age of 5. There were too few cases of sexual abuse to be considered. Positive outcomes were operationalized as achieving 5 or more grade A*-C GCSE exam grades at 16 years and scores above the cohort median on the self-report Warwick-Edinburgh Mental Wellbeing Scale and Bachmann Self-Esteem Scale at 17.5 years. The associations of individual, family and community covariates with successful adaptation to the adversity of maltreatment were investigated using logistic regression. School related factors, including engagement in extracurricular activities, satisfaction with school and not being bullied were the most important in facilitating resilience in educational attainment, self-esteem and wellbeing. Good communication and social skills was the most protective individual trait. There was insufficient evidence to suggest that family factors were associated with resilience to maltreatment. School-based interventions are recommended to promote positive adaptation following parental maltreatment. Future research should evaluate outcomes across the life-course to understand whether the protective influences of school persist into adulthood. Copyright © 2018. Published by Elsevier Ltd.

Magmatic Longevity Constrained by ID-TIMS U-Pb Dating of Zircon and Titanite

NASA Astrophysics Data System (ADS)

Szymanowski, D.; Wotzlaw, J. F.; Ellis, B. S.; Bachmann, O.; Von Quadt, A.

2016-12-01

Clues about the timescales and thermal conditions associated with the growth and evacuation of large silicic magma reservoirs are frequently drawn from radiometric dating, diffusion modelling, or thermomechanical modelling. A growing amount of petrological and geochronological evidence, supported by thermal modelling, suggests that many silicic magma reservoirs may exist for some 104-106 years in the form of high-crystallinity mushes at relatively low temperatures ( 700-750°C; [1-3]). Geochronological studies addressing this issue typically utilise the U-Pb system in zircon capable of recording extended periods of crystallisation, particularly in evolved calc-alkaline systems that spend most of their lifetime zircon-saturated. In this study, we integrate U-Pb dating of zircon and titanite to investigate the longevity of the magma reservoir that produced the Kneeling Nun Tuff, a 35 Ma, >900 km3 crystal-rich rhyolitic super-eruption from the Mogollon-Datil volcanic field in New Mexico (USA). High-precision ID-TIMS U-Pb dates of single crystals of both zircon and titanite independently record a continuous crystallisation history over >400,000 years. We combine the dating of both accessory phases with textural, major, trace element and isotopic studies of single crystals, placing tight constraints on the thermal conditions of magma accumulation and storage while recording differentiation and rejuvenation processes within the magma reservoir. The results suggest a protracted `cool' upper-crustal storage of magma prior to the Kneeling Nun Tuff eruption followed by a melting event which reduced the magma crystallinity and conditioned it for eruption. [1] Bachmann & Bergantz (2004), J. Petrol. 45, 1565-1582. [2] Gelman et al. (2013), Geology 41, 759-762. [3] Cooper & Kent (2014), Nature 506, 480-483.

The IVS data input to ITRF2014

NASA Astrophysics Data System (ADS)

Nothnagel, Axel; Alef, Walter; Amagai, Jun; Andersen, Per Helge; Andreeva, Tatiana; Artz, Thomas; Bachmann, Sabine; Barache, Christophe; Baudry, Alain; Bauernfeind, Erhard; Baver, Karen; Beaudoin, Christopher; Behrend, Dirk; Bellanger, Antoine; Berdnikov, Anton; Bergman, Per; Bernhart, Simone; Bertarini, Alessandra; Bianco, Giuseppe; Bielmaier, Ewald; Boboltz, David; Böhm, Johannes; Böhm, Sigrid; Boer, Armin; Bolotin, Sergei; Bougeard, Mireille; Bourda, Geraldine; Buttaccio, Salvo; Cannizzaro, Letizia; Cappallo, Roger; Carlson, Brent; Carter, Merri Sue; Charlot, Patrick; Chen, Chenyu; Chen, Maozheng; Cho, Jungho; Clark, Thomas; Collioud, Arnaud; Colomer, Francisco; Colucci, Giuseppe; Combrinck, Ludwig; Conway, John; Corey, Brian; Curtis, Ronald; Dassing, Reiner; Davis, Maria; de-Vicente, Pablo; De Witt, Aletha; Diakov, Alexey; Dickey, John; Diegel, Irv; Doi, Koichiro; Drewes, Hermann; Dube, Maurice; Elgered, Gunnar; Engelhardt, Gerald; Evangelista, Mark; Fan, Qingyuan; Fedotov, Leonid; Fey, Alan; Figueroa, Ricardo; Fukuzaki, Yoshihiro; Gambis, Daniel; Garcia-Espada, Susana; Gaume, Ralph; Gaylard, Michael; Geiger, Nicole; Gipson, John; Gomez, Frank; Gomez-Gonzalez, Jesus; Gordon, David; Govind, Ramesh; Gubanov, Vadim; Gulyaev, Sergei; Haas, Ruediger; Hall, David; Halsig, Sebastian; Hammargren, Roger; Hase, Hayo; Heinkelmann, Robert; Helldner, Leif; Herrera, Cristian; Himwich, Ed; Hobiger, Thomas; Holst, Christoph; Hong, Xiaoyu; Honma, Mareki; Huang, Xinyong; Hugentobler, Urs; Ichikawa, Ryuichi; Iddink, Andreas; Ihde, Johannes; Ilijin, Gennadiy; Ipatov, Alexander; Ipatova, Irina; Ishihara, Misao; Ivanov, D. V.; Jacobs, Chris; Jike, Takaaki; Johansson, Karl-Ake; Johnson, Heidi; Johnston, Kenneth; Ju, Hyunhee; Karasawa, Masao; Kaufmann, Pierre; Kawabata, Ryoji; Kawaguchi, Noriyuki; Kawai, Eiji; Kaydanovsky, Michael; Kharinov, Mikhail; Kobayashi, Hideyuki; Kokado, Kensuke; Kondo, Tetsuro; Korkin, Edward; Koyama, Yasuhiro; Krasna, Hana; Kronschnabl, Gerhard; Kurdubov, Sergey; Kurihara, Shinobu; Kuroda, Jiro; Kwak, Younghee; La Porta, Laura; Labelle, Ruth; Lamb, Doug; Lambert, Sébastien; Langkaas, Line; Lanotte, Roberto; Lavrov, Alexey; Le Bail, Karine; Leek, Judith; Li, Bing; Li, Huihua; Li, Jinling; Liang, Shiguang; Lindqvist, Michael; Liu, Xiang; Loesler, Michael; Long, Jim; Lonsdale, Colin; Lovell, Jim; Lowe, Stephen; Lucena, Antonio; Luzum, Brian; Ma, Chopo; Ma, Jun; Maccaferri, Giuseppe; Machida, Morito; MacMillan, Dan; Madzak, Matthias; Malkin, Zinovy; Manabe, Seiji; Mantovani, Franco; Mardyshkin, Vyacheslav; Marshalov, Dmitry; Mathiassen, Geir; Matsuzaka, Shigeru; McCarthy, Dennis; Melnikov, Alexey; Michailov, Andrey; Miller, Natalia; Mitchell, Donald; Mora-Diaz, Julian Andres; Mueskens, Arno; Mukai, Yasuko; Nanni, Mauro; Natusch, Tim; Negusini, Monia; Neidhardt, Alexander; Nickola, Marisa; Nicolson, George; Niell, Arthur; Nikitin, Pavel; Nilsson, Tobias; Ning, Tong; Nishikawa, Takashi; Noll, Carey; Nozawa, Kentarou; Ogaja, Clement; Oh, Hongjong; Olofsson, Hans; Opseth, Per Erik; Orfei, Sandro; Pacione, Rosa; Pazamickas, Katherine; Petrachenko, William; Pettersson, Lars; Pino, Pedro; Plank, Lucia; Ploetz, Christian; Poirier, Michael; Poutanen, Markku; Qian, Zhihan; Quick, Jonathan; Rahimov, Ismail; Redmond, Jay; Reid, Brett; Reynolds, John; Richter, Bernd; Rioja, Maria; Romero-Wolf, Andres; Ruszczyk, Chester; Salnikov, Alexander; Sarti, Pierguido; Schatz, Raimund; Scherneck, Hans-Georg; Schiavone, Francesco; Schreiber, Ulrich; Schuh, Harald; Schwarz, Walter; Sciarretta, Cecilia; Searle, Anthony; Sekido, Mamoru; Seitz, Manuela; Shao, Minghui; Shibuya, Kazuo; Shu, Fengchun; Sieber, Moritz; Skjaeveland, Asmund; Skurikhina, Elena; Smolentsev, Sergey; Smythe, Dan; Sousa, Don; Sovers, Ojars; Stanford, Laura; Stanghellini, Carlo; Steppe, Alan; Strand, Rich; Sun, Jing; Surkis, Igor; Takashima, Kazuhiro; Takefuji, Kazuhiro; Takiguchi, Hiroshi; Tamura, Yoshiaki; Tanabe, Tadashi; Tanir, Emine; Tao, An; Tateyama, Claudio; Teke, Kamil; Thomas, Cynthia; Thorandt, Volkmar; Thornton, Bruce; Tierno Ros, Claudia; Titov, Oleg; Titus, Mike; Tomasi, Paolo; Tornatore, Vincenza; Trigilio, Corrado; Trofimov, Dmitriy; Tsutsumi, Masanori; Tuccari, Gino; Tzioumis, Tasso; Ujihara, Hideki; Ullrich, Dieter; Uunila, Minttu; Venturi, Tiziana; Vespe, Francesco; Vityazev, Veniamin; Volvach, Alexandr; Vytnov, Alexander; Wang, Guangli; Wang, Jinqing; Wang, Lingling; Wang, Na; Wang, Shiqiang; Wei, Wenren; Weston, Stuart; Whitney, Alan; Wojdziak, Reiner; Yatskiv, Yaroslav; Yang, Wenjun; Ye, Shuhua; Yi, Sangoh; Yusup, Aili; Zapata, Octavio; Zeitlhoefler, Reinhard; Zhang, Hua; Zhang, Ming; Zhang, Xiuzhong; Zhao, Rongbing; Zheng, Weimin; Zhou, Ruixian; Zubko, Nataliya

2015-01-01

Very Long Baseline Interferometry (VLBI) is a primary space-geodetic technique for determining precise coordinates on the Earth, for monitoring the variable Earth rotation and orientation with highest precision, and for deriving many other parameters of the Earth system. The International VLBI Service for Geodesy and Astrometry (IVS, http://ivscc.gsfc.nasa.gov/) is a service of the International Association of Geodesy (IAG) and the International Astronomical Union (IAU). The datasets published here are the results of individual Very Long Baseline Interferometry (VLBI) sessions in the form of normal equations in SINEX 2.0 format (http://www.iers.org/IERS/EN/Organization/AnalysisCoordinator/SinexFormat/sinex.html, the SINEX 2.0 description is attached as pdf) provided by IVS as the input for the next release of the International Terrestrial Reference System (ITRF): ITRF2014. This is a new version of the ITRF2008 release (Bockmann et al., 2009). For each session/ file, the normal equation systems contain elements for the coordinate components of all stations having participated in the respective session as well as for the Earth orientation parameters (x-pole, y-pole, UT1 and its time derivatives plus offset to the IAU2006 precession-nutation components dX, dY (https://www.iau.org/static/resolutions/IAU2006_Resol1.pdf). The terrestrial part is free of datum. The data sets are the result of a weighted combination of the input of several IVS Analysis Centers. The IVS contribution for ITRF2014 is described in Bachmann et al (2015), Schuh and Behrend (2012) provide a general overview on the VLBI method, details on the internal data handling can be found at Behrend (2013).

The development of the Middle Triassic tectonical controlled Germanic Basin of Central Europe and the palaeoenvironmental related distribution of marine and terrestrial reptiles

NASA Astrophysics Data System (ADS)

Diedrich, Cajus G.

2010-05-01

Nine Middle Triassic paleogeographical maps comprising the uppermost Upper Bunter, Lower to Middle Muschelkalk and Upper Muschelkalk to Lower Keuper time frame (Diedrich 2008b) show the marine ingression and regression cycle of the Middle Triassic Germanic Basin (Diedrich 2010c). For bathymetrical and palaeoenvironmental interpretations especially reptiles and their footprints are used. This Germanic Basin as analogon for the Arabian Gulf (Knaust 1997), north of the Tethys, was under marine and finally terrestrial influenced sediments in a time frame (after Kozur and Bachmann 2008) between 247.2 My (Myophoria Fm, Aegean, Lower Anisian) to 237.9 My (Grabfeld Fm, Longobardian, Lower Ladinian). In a duration of 9.3 My the Germanic Basin was filled up mainly with marine carbonates and at the end by siliciclastics influenced by the northern Tethys through the Silesian, Carpathian and later the Burgundian Gates which connected the Germanic Basin to the Northern Tethys. With the marine ingression from the East via the Silesian Gate (Poland) a ten to hundred kilometers extended intertidal flat to sabkha facies belt surrounded first only the central and then the Western Germanic Basin (Winterswijk, Netherlands). Those intertidal zones were used mainly by two different small reptiles as their primary habitat. Hereby they left Millions of the small tom medium sized footprints of the ichnogenera Rhynchosauroides and Procolophonichnium (Diedrich 2005, 2008a). Larger terrestrial and beach and sabkha adapted reptiles were Tanystrophaeus antiquus and unknown archosaurs, which are recorded only by their footprints. At the beginning of the ingression at the uppermost Bunter a shallow marine invertebrate fauna and coastal reptiles appeared in the Germanic Basin which must have originated mainly from the Northern Tethys. Especially all marine reptiles immigrated from the Tethys which is proven not only by assamblaged Tethyan cephalopod Ceratite species (cf. Diedrich 2008a). The

What do kids think about kids in eyeglasses?

PubMed

Walline, Jeffrey J; Sinnott, Loraine; Johnson, Erica D; Ticak, Anita; Jones, Sylvia L; Jones, Lisa A

2008-05-01

Previous studies have examined how people feel about others who wear glasses, but no studies of children have been published on the subject. We conducted the Children's Attitudes about Kids in Eyeglasses (CAKE) study to determine how children feel about other children who wear glasses. Subjects compared a series of 24 picture pairs and answered six questions regarding which child ...he or she would rather play with, looks better at playing sports, appears smarter (more intelligent), appears nicer, looks more shy and looks more honest. The children in each pair of pictures differed by gender, ethnicity and spectacle wear. Logistic regression was performed to determine the probability and confidence interval that a subject would pick a particular child. Eighty subjects between the ages of 6 and 10 years participated. The average (+/-SD) age of the subjects was 8.3 +/- 1.3 years, 42 (53%) were females, 51 (64%) were whites, 21 (26%) were blacks, and 30 (38%) wore glasses. The spectacle wearer appeared smarter (0.66, CI = 0.60-0.71) and more honest (0.57, CI = 0.50-0.64), and children who wore glasses looked smarter regardless of whether the child picking wore glasses. Both boys (0.66, CI = 0.68-0.79) and girls (0.77, CI = 0.71-0.82) thought that boys looked better at playing sports. The old adage 'Boys never make passes at lasses who wear glasses' may be outmoded, but glasses may tend to make children look smarter and slightly more honest to their peers.

A place-based model of local activity spaces: individual place exposure and characteristics

NASA Astrophysics Data System (ADS)

Hasanzadeh, Kamyar; Laatikainen, Tiina; Kyttä, Marketta

2018-01-01

Researchers for long have hypothesized relationships between mobility, urban context, and health. Despite the ample amount of discussions, the empirical findings corroborating such associations remain to be marginal in the literature. It is growingly believed that the weakness of the observed associations can be largely explained by the common misspecification of the geographical context. Researchers coming from different fields have developed a wide range of methods for estimating the extents of these geographical contexts. In this article, we argue that no single approach yet has sufficiently been capable of capturing the complexity of human mobility patterns. Subsequently, we discuss that reaching a better understanding of individual activity spaces can be possible through a spatially sensitive estimation of place exposure. Following this discussion, we take an integrative person and place-based approach to create an individualized residential exposure model (IREM) to estimate the local activity spaces (LAS) of the individuals. This model is created using data collected through public participation GIS. Following a brief comparison of IREM with other commonly used LAS models, the article continues by presenting an empirical study of aging citizens in Helsinki area to demonstrate the usability of the proposed framework. In this study, we identify the main dimensions of LASs and seek their associations with socio-demographic characteristics of individuals and their location in the region. The promising results from comparisons and the interesting findings from the empirical part suggest both a methodological and conceptual improvement in capturing the complexity of local activity spaces.

A novel intra-operative, high-resolution atrial mapping approach.

PubMed

Yaksh, Ameeta; van der Does, Lisette J M E; Kik, Charles; Knops, Paul; Oei, Frans B S; van de Woestijne, Pieter C; Bekkers, Jos A; Bogers, Ad J J C; Allessie, Maurits A; de Groot, Natasja M S

2015-12-01

A new technique is demonstrated for extensive high-resolution intra-operative atrial mapping that will facilitate the localization of atrial fibrillation (AF) sources and identification of the substrate perpetuating AF. Prior to the start of extra-corporal circulation, a 8 × 24-electrode array (2-mm inter-electrode distance) is placed subsequently on all the right and left epicardial atrial sites, including Bachmann's bundle, for recording of unipolar electrograms during sinus rhythm and (induced) AF. AF is induced by high-frequency pacing at the right atrial free wall. A pacemaker wire stitched to the right atrium serves as a reference signal. The indifferent pole is connected to a steal wire fixed to subcutaneous tissue. Electrograms are recorded by a computerized mapping system and, after amplification (gain 1000), filtering (bandwidth 0.5-400 Hz), sampling (1 kHz) and analogue to digital conversion (16 bits), automatically stored on hard disk. During the mapping procedure, real-time visualization secures electrogram quality. Analysis will be performed offline. This technique was performed in 168 patients of 18 years and older, with coronary and/or structural heart disease, with or without AF, electively scheduled for cardiac surgery and a ventricular ejection fraction above 40 %. The mean duration of the entire mapping procedure including preparation time was 9 ± 2 min. Complications related to the mapping procedure during or after cardiac surgery were not observed. We introduce the first epicardial atrial mapping approach with a high resolution of ≥1728 recording sites which can be performed in a procedure time of only 9±2 mins. This mapping technique can potentially identify areas responsible for initiation and persistence of AF and hopefully can individualize both diagnosis and therapy of AF.

Spatial distribution of conduction disorders during sinus rhythm.

PubMed

Lanters, Eva A H; Yaksh, Ameeta; Teuwen, Christophe P; van der Does, Lisette J M E; Kik, Charles; Knops, Paul; van Marion, Denise M S; Brundel, Bianca J J M; Bogers, Ad J J C; Allessie, Maurits A; de Groot, Natasja M S

2017-12-15

Length of lines of conduction block (CB) during sinus rhythm (SR) at Bachmann's bundle (BB) is associated with atrial fibrillation (AF). However, it is unknown whether extensiveness of CB at BB represents CB elsewhere in the atria. We aim to investigate during SR 1) the spatial distribution and extensiveness of CB 2) whether there is a predilection site for CB and 3) the association between CB and incidence of post-operative AF. During SR, epicardial mapping of the right atrium (RA), BB and left atrium was performed in 209 patients with coronary artery disease. The amount of conduction delay (CD, Δlocal activation time ≥7ms) and CB (Δ≥12ms) was quantified as % of the mapping area. Atrial regions were compared to identify potential predilection sites for CD/CB. Correlations between CD/CB and clinical characteristics were tested. Areas with CD or CB were present in all patients, overall prevalence was respectively 1.4(0.2-4.0) % and 1.3(0.1-4.3) %. Extensiveness and spatial distribution of CD/CB varied considerably, however occurred mainly at the superior intercaval RA. Of all clinicalcharacteristics, CD/CB only correlated weakly with age and diabetes (P<0.05). A 1% increase in CD or CB caused a 1.1-1.5ms prolongation of the activation time (P<0.001). There was no correlation between CD/CB and post-operative AF. CD/CB during SR in CABG patients with electrically non-remodeled atria show considerable intra-atrial, but also inter-individual variation. Despite these differences, a predilection site is present at the superior intercaval RA. Extensiveness of CB at the superior intercaval RA or BB does not reflect CB elsewhere in the atria and is not associated with post-operative AF. Copyright © 2017 Elsevier B.V. All rights reserved.

Increased Earthquake Rates in the Central and Eastern US Portend Higher Earthquake Hazards

NASA Astrophysics Data System (ADS)

Llenos, A. L.; Rubinstein, J. L.; Ellsworth, W. L.; Mueller, C. S.; Michael, A. J.; McGarr, A.; Petersen, M. D.; Weingarten, M.; Holland, A. A.

2014-12-01

Since 2009 the central and eastern United States has experienced an unprecedented increase in the rate of M≥3 earthquakes that is unlikely to be due to natural variation. Where the rates have increased so has the seismic hazard, making it important to understand these changes. Areas with significant seismicity increases are limited to areas where oil and gas production take place. By far the largest contributor to the seismicity increase is Oklahoma, where recent studies suggest that these rate changes may be due to fluid injection (e.g., Keranen et al., Geology, 2013; Science, 2014). Moreover, the area of increased seismicity in northern Oklahoma that began in 2013 coincides with the Mississippi Lime play, where well completions greatly increased the year before the seismicity increase. This suggests a link to oil and gas production either directly or from the disposal of significant amounts of produced water within the play. For the purpose of assessing the hazard due to these earthquakes, should they be treated differently from natural earthquakes? Previous studies suggest that induced seismicity may differ from natural seismicity in clustering characteristics or frequency-magnitude distributions (e.g., Bachmann et al., GJI, 2011; Llenos and Michael, BSSA, 2013). These differences could affect time-independent hazard computations, which typically assume that clustering and size distribution remain constant. In Oklahoma, as well as other areas of suspected induced seismicity, we find that earthquakes since 2009 tend to be considerably more clustered in space and time than before 2009. However differences between various regional and national catalogs leave unclear whether there are significant changes in magnitude distribution. Whether they are due to natural or industrial causes, the increased earthquake rates in these areas could increase the hazard in ways that are not accounted for in current hazard assessment practice. Clearly the possibility of induced

Efficient strategies to find diagnostic test accuracy studies in kidney journals.

PubMed

Rogerson, Thomas E; Ladhani, Maleeka; Mitchell, Ruth; Craig, Jonathan C; Webster, Angela C

2015-08-01

Nephrologists looking for quick answers to diagnostic clinical questions in MEDLINE can use a range of published search strategies or Clinical Query limits to improve the precision of their searches. We aimed to evaluate existing search strategies for finding diagnostic test accuracy studies in nephrology journals. We assessed the accuracy of 14 search strategies for retrieving diagnostic test accuracy studies from three nephrology journals indexed in MEDLINE. Two investigators hand searched the same journals to create a reference set of diagnostic test accuracy studies to compare search strategy results against. We identified 103 diagnostic test accuracy studies, accounting for 2.1% of all studies published. The most specific search strategy was the Narrow Clinical Queries limit (sensitivity: 0.20, 95% CI 0.13-0.29; specificity: 0.99, 95% CI 0.99-0.99). Using the Narrow Clinical Queries limit, a searcher would need to screen three (95% CI 2-6) articles to find one diagnostic study. The most sensitive search strategy was van der Weijden 1999 Extended (sensitivity: 0.95; 95% CI 0.89-0.98; specificity 0.55, 95% CI 0.53-0.56) but required a searcher to screen 24 (95% CI 23-26) articles to find one diagnostic study. Bachmann 2002 was the best balanced search strategy, which was sensitive (0.88, 95% CI 0.81-0.94), but also specific (0.74, 95% CI 0.73-0.75), with a number needed to screen of 15 (95% CI 14-17). Diagnostic studies are infrequently published in nephrology journals. The addition of a strategy for diagnostic studies to a subject search strategy in MEDLINE may reduce the records needed to screen while preserving adequate search sensitivity for routine clinical use. © 2015 Asian Pacific Society of Nephrology.

Using 13C-labeled benzene and Raman gas spectroscopy to investigate respiration and biodegradation kinetics following soil contamination

NASA Astrophysics Data System (ADS)

Jochum, Tobias; Popp, Juergen; Frosch, Torsten

2016-04-01

Soil and groundwater contamination with benzene can cause serious environmental damages. However, many soil microorganisms are capable to adapt and known to strongly control the fate of organic contamination. Cavity enhanced Raman gas spectroscopy (CERS) was applied to investigate the short-term response of indigenous soil bacteria to a sudden surface contamination with benzene regarding the temporal variations of gas products and their exchange rates with the adjacent atmosphere. 13C-labeled benzene was spiked on a silty-loamy soil column (sampled from Hainich National Park, Germany) in order to track and separate the changes in heterotrophic soil respiration - involving 12CO2 and O2 - from the microbial process of benzene degradation, which ultimately forms 13CO2.1 The respiratory quotient (RQ) of 0.98 decreased significantly after the spiking and increased again within 33 hours to a value of 0.72. This coincided with maximum 13CO2 concentration rates (0.63 μ mol m-2 s-1), indicating highest benzene degradation at 33 hours after the spiking event. The diffusion of benzene in the headspace and the biodegradation into 13CO2 were simultaneously monitored and 12 days after the benzene spiking no measurable degradation was detected anymore.1 The RQ finally returned to a value of 0.96 demonstrating the reestablished aerobic respiration. In summary, this study shows the potential of combining Raman gas spectroscopy and stable isotopes to follow soil microbial biodegradation dynamics while simultaneously monitoring the underlying respiration behavior. Support by the Collaborative Research Center 1076 Aqua Diva is kindly acknowledged. We thank Beate Michalzik for soil analysis and discussion. 1. T. Jochum, B. Michalzik, A. Bachmann, J. Popp and T. Frosch, Analyst, 2015, 140, 3143-3149.

Heat Transfar Properties of Flat-Panel Evacuated Porous Insrlators

NASA Astrophysics Data System (ADS)

Yoneno, Hirosyi; Yamamoto, Ryoichi

Flat Panel evacuated porous insulators have been produced by filling powder or fiber (such as perlite powder, diatomaceous earth powder, silica aerogel powder, g lass fiber and ceramic fiber) in film-like laminated plastic container and by evacuating to form vacuum in it is interior. Heat transfer properties of these evacuated insulators have been studied under various conditions (such as particle diameter, surface area, packing density, solid volume fraction and void dimension). The apparent mean thermal conductivity has been measured for the boundary surface temperature at cold face temperature 13°C and hot face temperature 35°. The effect of air pressure ranging from 1 Pa to one atomosphere (105 Pa) was examined. The results were as follows. (1) For each powder the apparent mean thermal conductivity decreases with decreasing residual air pressure, and at very low pressure bellow 1 -103 Pa the conductivity becomes indeqendent of pressure. The thermal conductivity at 1.3Pa is 0.0053 W/mK for perlite powder, 0.0048W/mK for diatomaceous earth powder, 0.0043 W/mK for silica aerogel powder and 0.0029W/mK for glass fiber. (2) With decreasing particle size, the apparent mean thermal conductivity is constant independent of residual air pressure in higher pressure region. It is that void dimension continues to decrease with particle size and the mean free path of air becomes comparable with void dimension. (3) In the range of minor solid volume fraction, the apparent mean thermal conductivity at very low precreases with decreasing particle size. This shows the thermal contact resistance of the solid particle increases with decreasing particle size.

ASPECT: A Survey to Assess Student Perspective of Engagement in an Active-Learning Classroom.

PubMed

Wiggins, Benjamin L; Eddy, Sarah L; Wener-Fligner, Leah; Freisem, Karen; Grunspan, Daniel Z; Theobald, Elli J; Timbrook, Jerry; Crowe, Alison J

2017-01-01

The primary measure used to determine relative effectiveness of in-class activities has been student performance on pre/posttests. However, in today's active-learning classrooms, learning is a social activity, requiring students to interact and learn from their peers. To develop effective active-learning exercises that engage students, it is important to gain a more holistic view of the student experience in an active-learning classroom. We have taken a mixed-methods approach to iteratively develop and validate a 16-item survey to measure multiple facets of the student experience during active-learning exercises. The instrument, which we call A ssessing S tudent P erspective of E ngagement in C lass T ool (ASPECT), was administered to a large introductory biology class, and student responses were subjected to exploratory factor analysis. The 16 items loaded onto three factors that cumulatively explained 52% of the variation in student response: 1) value of activity, 2) personal effort, and 3) instructor contribution. ASPECT provides a rapid, easily administered means to measure student perception of engagement in an active-learning classroom. Gaining a better understanding of students' level of engagement will help inform instructor best practices and provide an additional measure for comprehensively assessing the impact of different active-learning strategies. © 2017 B. L. Wiggins, S. L. Eddy, et al. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Vom Urknall zum Durchknall

NASA Astrophysics Data System (ADS)

Unzicker, Alexander

Lautstarker Applaus erhob sich im Salon III/IV des Marriott-Hotels von Crystal City im amerikanischen Bundesstaat Virginia. In dem überfüllten Konferenzraum starrten alle wie gebannt auf die Leinwand, wo nicht mehr zu sehen war als ein nüchternes Diagramm aus zahlreichen Punkten und einer geschwungenen Kurve. Nureine eigenartige Personengruppe konnte sich davon zu Emotionen hinreißen lassen - Physiker auf der Jahrestagung der Astronomischen Gesellschaft, die ihren Begeisterungssturm noch minutenlang fortsetzten. Was war geschehen? Die im Diagramm aufgetragenen Daten bestätigten mit einer nie da gewesenen Genauigkeit ein fundamentales Naturgesetz zur Wärmeabstrahlung von heißen Körpern. 1900 von Max Planck entdeckt, leuchtete es nun in geradezu mathematischer Reinheit auf. Noch sensationeller war der Ursprung der Daten - Mikrowellensignale verschiedener Frequenzen, die nicht aus einem irdischen Labor stammten, sondern von einem heißen Urzustand des Universums! Ein Feuerball aus Wasserstoff und Helium, noch ohne jegliche Strukturen, die irgendwann Leben ermöglichen sollten, ließ damals seinem Licht freien Lauf. Mehr als zehn Milliarden Jahre war es bis zu den Detektoren des vom Menschen gebauten Satelliten COBE unterwegs, der wenige Tage zuvor die Daten übertragen hatte. Wenn ich das alles wie einen Film in meiner Vorstellung ablaufen lasse, bekomme ich immer eine Gänsehaut, als würde ich die inzwischen extrem abgekühlte Strahlung tatsächlich spüren. Ihre Gleichverteilung im Raum macht uns auch deutlich, dass wir uns nicht einbilden dürfen, an einem besonderen Ort im Universum zu leben - intelligente Aliens könnten sich seitdem überall entwickelt haben! Sollten sie - was nicht wahrscheinlich ist - uns wirklich von Zeit zu Zeit über die Schulter schauen, dann hätten sie an jenem Nachmittag des 13. Januar 1990, als der Vortrag stattfand, bestimmt anerkennend mit ihrem großen Kopf genickt.

Reducing social inequalities in access to overweight and obesity care management for adolescents: The PRALIMAP-INÈS trial protocol and inclusion data analysis.

PubMed

Legrand, Karine; Lecomte, Edith; Langlois, Johanne; Muller, Laurent; Saez, Laura; Quinet, Marie-Hélène; Böhme, Philip; Spitz, Elisabeth; Omorou, Abdou Y; Briançon, Serge

2017-09-01

Despite social inequalities in overweight/obesity prevalence, evidence-based public health interventions to reduce them are scarce. The PRALIMAP-INÈS trial aimed to investigate whether a strengthened-care management for adolescents with low socioeconomic status has an equivalent effect in preventing and reducing overweight as a standard-care management for high socioeconomic status adolescents. PRALIMAP-INÈS was a mixed, prospective and multicenter trial including 35 state-run schools. It admitted overweight or obese adolescents, age 13-18 years old, for 3 consecutive academic years. One-year interventions were implemented. Data were collected before (T0), after (T1) and post (T2) intervention. Among 2113 eligible adolescents who completed questionnaires, 1639 were proposed for inclusion and 1419 were included (220 parental refusals). Two groups were constituted according to the Family Affluence Scale (FAS) score: the less advantaged (FAS≤5) were randomly assigned to 2 groups in a 2/1 ratio. The 3 intervention groups were: advantaged with standard-care management (A.S, n = 808), less advantaged with standard-care management (LA.S, n = 196), and less advantaged with standard and strengthened-care management (LA.S.S, n = 415). The standard-care management was based on the patient education principle and consisted of 5 collective sessions. The strengthened-care management was based on the proportionate universalism principle and consisted of activities adapted to needs. The written parental refusal was less frequent among less advantaged and more overweight adolescents. A dramatic linear social gradient in overweight was evidenced. The PRALIMAP-INÈS outcomes should inform how effectively a socially adapted public health program can avoid worsening social inequalities in overweight adolescents attending school. ClinicalTrials.gov (NCT01688453).

Adenosine A2A receptor agonist prevents cardiac remodeling and dysfunction in spontaneously hypertensive male rats after myocardial infarction

PubMed Central

da Silva, Jaqueline S; Gabriel-Costa, Daniele; Sudo, Roberto T; Wang, Hao; Groban, Leanne; Ferraz, Emanuele B; Nascimento, José Hamilton M; Fraga, Carlos Alberto M; Barreiro, Eliezer J; Zapata-Sudo, Gisele

2017-01-01

Background This work evaluated the hypothesis that 3,4-methylenedioxybenzoyl-2-thienylhydrazone (LASSBio-294), an agonist of adenosine A2A receptor, could be beneficial for preventing cardiac dysfunction due to hypertension associated with myocardial infarction (MI). Methods Male spontaneously hypertensive rats (SHR) were randomly divided into four groups (six animals per group): sham-operation (SHR-Sham), and myocardial infarction rats (SHR-MI) were treated orally either with vehicle or LASSBio-294 (10 and 20 mg.kg−1.d−1) for 4 weeks. Echocardiography and in vivo hemodynamic parameters measured left ventricle (LV) structure and function. Exercise tolerance was evaluated using a treadmill test. Cardiac remodeling was accessed by LV collagen deposition and tumor necrosis factor α expression. Results Early mitral inflow velocity was significantly reduced in the SHR-MI group, and there was significant recovery in a dose-dependent manner after treatment with LASSBio-294. Exercise intolerance observed in the SHR-MI group was prevented by 10 mg.kg−1.d−1 of LASS-Bio-294, and exercise tolerance exceeded that of the SHR-Sham group at 20 mg.kg−1.d−1. LV end-diastolic pressure increased after MI, and this was prevented by 10 and 20 mg.kg−1.d−1 of LASSBio-294. Sarcoplasmic reticulum Ca2+ ATPase levels were restored in a dose-dependent manner after treatment with LASSBio-294. Fibrosis and inflammatory processes were also counteracted by LASSBio-294, with reductions in LV collagen deposition and tumor necrosis factor α expression. Conclusion In summary, oral administration of LASSBio-294 after MI in a dose-dependent manner prevented the development of cardiac dysfunction, demonstrating this compound’s potential as an alternative treatment for heart failure in the setting of ischemic heart disease with superimposed chronic hypertension. PMID:28293100

Carbon Mobility at Subduction Interfaces via Deformation-Enhanced Fluid Infiltration: Evidence from the Swiss/Italian Alps

NASA Astrophysics Data System (ADS)

Jaeckel, K. P.; Bebout, G. E.; Angiboust, S.

2016-12-01

The interplay between fluid flow and deformation along subduction interfaces, and the extent to which deformation-enhanced fluid infiltration can drive decarbonation and carbonate dissolution, remain poorly understood. Recent work on HP/UHP decarbonation in W. Alps suites has indicated that, in intact volumes of metasediment, metabasalt, and ophicarbonate away from major shear zones and with few veins, carbonate is largely retained to 80-90 km depths (Cook-Kollars et al., 2014; Collins et al., 2015; Chem. Geol.). Yet uncertain is whether forearc fluid infiltration focused in intensely sheared and fractured zones could result in greater mobilization of C from subducting sections, in quantities sufficient to impact subduction zone C cycling. Lower-plate rocks at Arosa and Dent Blanche interface exposures (Bachmann et al., 2009, JGR; Angiboust et al., 2015, G3) are primarily calc-schist intercalated with meta-ultramafic and metamafic schist and contain carbonate-bearing veins of varying abundance and texture. At some localities, these sections contain blocks of carbonate, metabasalt, and upper-plate gneiss. Strongly deformed veins concordant with the foliation parallel to the thrust interface commonly contain carbonate and quartz. In highly sheared regions in the Arosa Zone, δ18O(VSMOW) values of some host-rocks and veins are shifted from +20 ± 2‰, values observed regionally for the Schistes Lustres, to values of +11 to +13‰. These shifts can be explained by interaction with externally-derived H2O-rich fluids with δ18O of +9 to +11‰. Smaller datasets for Dent Blanche localities hint at similar δ18O shifts. Most of these rocks contain little evidence of C release by decarbonation reactions. Evidence exists for local-scale dissolution of carbonate, during pressure solution, and carbonate-bearing veins reflect C mobility in fluids. Ongoing work assesses whether volumes of carbonate removed in some regions balance with those precipitated nearby in veins and

Exploring the plasma chemistry in microwave chemical vapor deposition of diamond from C/H/O gas mixtures.

PubMed

Kelly, Mark W; Richley, James C; Western, Colin M; Ashfold, Michael N R; Mankelevich, Yuri A

2012-09-27

Microwave (MW)-activated CH(4)/CO(2)/H(2) gas mixtures operating under conditions relevant to diamond chemical vapor deposition (i.e., X(C/Σ) = X(elem)(C)/(X(elem)(C) + X(elem)(O)) ≈ 0.5, H(2) mole fraction = 0.3, pressure, p = 150 Torr, and input power, P = 1 kW) have been explored in detail by a combination of spatially resolved absorption measurements (of CH, C(2)(a), and OH radicals and H(n = 2) atoms) within the hot plasma region and companion 2-dimensional modeling of the plasma. CO and H(2) are identified as the dominant species in the plasma core. The lower thermal conductivity of such a mixture (cf. the H(2)-rich plasmas used in most diamond chemical vapor deposition) accounts for the finding that CH(4)/CO(2)/H(2) plasmas can yield similar maximal gas temperatures and diamond growth rates at lower input powers than traditional CH(4)/H(2) plasmas. The plasma chemistry and composition is seen to switch upon changing from oxygen-rich (X(C/Σ) < 0.5) to carbon-rich (X(C/Σ) > 0.5) source gas mixtures and, by comparing CH(4)/CO(2)/H(2) (X(C/Σ) = 0.5) and CO/H(2) plasmas, to be sensitive to the choice of source gas (by virtue of the different prevailing gas activation mechanisms), in contrast to C/H process gas mixtures. CH(3) radicals are identified as the most abundant C(1)H(x) [x = 0-3] species near the growing diamond surface within the process window for successful diamond growth (X(C/Σ) ≈ 0.5-0.54) identified by Bachmann et al. (Diamond Relat. Mater.1991, 1, 1). This, and the findings of similar maximal gas temperatures (T(gas) ~2800-3000 K) and H atom mole fractions (X(H)~5-10%) to those found in MW-activated C/H plasmas, points to the prevalence of similar CH(3) radical based diamond growth mechanisms in both C/H and C/H/O plasmas.

Histological evidence of inflammatory reaction associated with fibrosis in the atrial and ventricular walls in a case-control study of patients with history of atrial fibrillation.

PubMed

Mitrofanova, Lubov B; Orshanskaya, Victoria; Ho, Siew Yen; Platonov, Pyotr G

2016-12-01

Chronic inflammation in the atrial myocardium was shown to play an important role in the development of atrial fibrosis in patients with atrial fibrillation (AF). However, it is not clear to what extent atrial inflammatory reaction associated with AF extends on the ventricular myocardium. Our aim was to assess the extent of fibrosis and lymphomononuclear infiltration in human ventricular myocardium and explore its association with AF. Medical records from consecutive autopsies were checked for presence of AF. Heart specimens from 30 patients died from cardiovascular causes (64 ± 12 years, 17 men) were collected in three equal groups: no AF, paroxysmal AF, and permanent AF. Tissue samples were taken from the Bachmann's bundle, crista terminalis, posterior left atrium, left ventricle and right ventricle free walls and stained with Masson's trichrome for analysis of fibrosis extent. Immunohistochemistry was performed using antibodies against CD3- and CD45-antigens and quantified as number of antigen-positive cells per 1 mm 2 . Fibrosis extent, CD3+ and CD45+ cell counts were elevated in AF patients at all sites (P < 0.001 for all). Fibrosis extent demonstrated correlation with both CD3+ and CD45+ cell counts in the right (r = 0.781, P < 0.001 for CD45+ and r = 0.720, P < 0.001 for CD3+) and the left (r = 0.515, P = 0.004 for CD45+ and r = 0.573, P = 0.001 for CD3+) ventricles. Neither fibrosis nor inflammatory cell count showed association with either age or comorbidities. Histological signs of chronic inflammation affecting ventricular myocardium are strongly associated with AF and demonstrate significant correlation with fibrosis extent that cannot be explained by cardiovascular comorbidities otherwise. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For Permissions, please email: journals.permissions@oup.com.

Accessory Mineral Depth-Profiling Applied to the Corsican Lower Crust: A Continuous Thermal History of Mesozoic Continental Rifting

NASA Astrophysics Data System (ADS)

Seymour, N. M.; Stockli, D. F.; Beltrando, M.; Smye, A.

2015-12-01

Despite advances in understanding the structural development of hyperextended magma-poor rift margins, the temporal and thermal evolution of lithospheric hyperextension during rifting remains only poorly understood. In contrast to classic pure-shear models, multi-stage rift models that include depth-dependent thinning predict significant lower-crustal reheating during the necking phase due to buoyant rise of the asthenosphere. The Santa Lucia nappe of NE Corsica is an ideal laboratory to test for lower-crustal reheating as it preserves Permian lower crust exhumed from granulitic conditions during Mesozoic Tethyan rifting. This study presents the first use of apatite U-Pb depth-profile thermochronology in conjunction with novel rutile U-Pb and zircon U-Pb thermo- and geochronology to reconstruct a continuous t-T path to constrain the syn-rift thermal evolution of this exposed lower-crustal section. LASS-ICP-MS depth-profile analyses of zircon reveal thin (<10 μm) ~210-180 Ma overgrowths on 300-270 Ma cores in lower-crustal lithologies, indicative of renewed thermal activity during Mesozoic rifting. Cooling due to rapid rift margin exhumation is recorded by the topology of rutile and apatite depth profiles caused by thermally-activated volume diffusion at T >400°C. Lower-crustal rutile reveal a rounded progression from core plateaus at ~170 Ma to 150-145 Ma at the outer 8-10 μm of grains while middle-crustal apatite records 170 Ma cores grading to 140-135 Ma rims. Inverse modeling of rutile profiles suggests the lower crust cooled from 700°C at 200 Ma to 425°C at 140 Ma. Middle-crustal apatite yield a two-stage history, with rapid cooling from 500°C at 200 Ma to 420°C at ~180 Ma followed by slow cooling to 400°C by 160 Ma. Combined with zircon overgrowth ages, these data indicate the Santa Lucia nappe underwent a thermal pulse in the late Triassic-early Jurassic associated with depth-dependent thinning and hyperextension of the Corsican margin.

Two modes of orogenic collapse of the Pamir plateau recorded by titanite

NASA Astrophysics Data System (ADS)

Stearns, M. A.; Hacker, B. R.; Ratschbacher, L.; Rutte, D.; Kylander-Clark, A. R.

2013-12-01

Processes that operate in the mid- to lower crust during and following continent-continent collision are important for understanding how orogenic plateaux transition from thickening to collapse. In the central and southern Pamir, mid- to lower crustal rocks crop out in two belts of extensional domes. The central Pamir domes were exhumed by symmetrical N-S extension. In contrast, the southern Pamir domes were exhumed by asymmetrical top to the south (NNW-SSE) extension via a rolling-hinge detachment. To investigate the high-temperature exhumation history, titanites were dated using LASS (laser ablation split stream-ICP-MS). A multi-collector ICP was used to collect U-Pb isotopic ratios and a single collector ICP-MS was used to measure trace-element abundances. The data indicate that the central Pamir domes began exhumation synchronously at ~17 Ma. Titanite from the southern Pamir record two periods of protracted (re)crystallization: older metamorphic dates ranging from ~35-18 Ma and younger igneous and metamorphic dates from ~15-7 Ma. Samples with single populations of titanite dates are present throughout both groups. Samples with more-complex date populations typically have distinct trace-element (e.g., Sr, Y, Zr, and Nb) groups that can be used to distinguish different date populations (e.g., older dates may have higher Zr and younger dates lower Zr). The distinct early exhumation histories of the north and south Pamir require either a diachronous single process or two semi-independent processes. The N to S sequence of exhumation, ranges of dates, and overall extension directions may be related to two important plate-tectonic events inferred from seismic data: 1) breakoff of the northward subducting Indian slab around ~20 Ma, and 2) southward subduction and northwestward rollback of the Asian lithosphere between ~15-10 Ma based on geodetic convergence rates and Benioff zone length. We interpret these two lithospheric-detachment events to have driven the

On the Discrepancy in Simultaneous Observations of the Structure Parameter of Temperature Using Scintillometers and Unmanned Aircraft

NASA Astrophysics Data System (ADS)

Braam, Miranda; Beyrich, Frank; Bange, Jens; Platis, Andreas; Martin, Sabrina; Maronga, Björn; Moene, Arnold F.

2016-02-01

We elaborate on the preliminary results presented in Beyrich et al. (in Boundary-Layer Meteorol 144:83-112, 2012), who compared the structure parameter of temperature ({CT^2}_{}) obtained with the unmanned meteorological mini aerial vehicle (M2 AV) versus {CT^2}_{} obtained with two large-aperture scintillometers (LASs) for a limited dataset from one single experiment (LITFASS-2009). They found that {CT^2}_{} obtained from the M2 AV data is significantly larger than that obtained from the LAS data. We investigate if similar differences can be found for the flights on the other six days during LITFASS-2009 and LITFASS-2010, and whether these differences can be reduced or explained through a more elaborate processing of both the LAS data and the M2 AV data. This processing includes different corrections and measures to reduce the differences between the spatial and temporal averaging of the datasets. We conclude that the differences reported in Beyrich et al. can be found for other days as well. For the LAS-derived values the additional processing steps that have the largest effect are the saturation correction and the humidity correction. For the M2 AV -derived values the most important step is the application of the scintillometer path-weighting function. Using the true air speed of the M2 AV to convert from a temporal to a spatial structure function rather than the ground speed (as in Beyrich et al.) does not change the mean discrepancy, but it does affect {CT^2}_{} values for individual flights. To investigate whether {CT^2}_{} derived from the M2 AV data depends on the fact that the underlying temperature dataset combines spatial and temporal sampling, we used large-eddy simulation data to analyze {CT^2}_{} from virtual flights with different mean ground speeds. This analysis shows that {CT^2}_{} does only slightly depends on the true air speed when averaged over many flights.

Area-averaged evapotranspiration over a heterogeneous land surface: aggregation of multi-point EC flux measurements with a high-resolution land-cover map and footprint analysis

NASA Astrophysics Data System (ADS)

Xu, Feinan; Wang, Weizhen; Wang, Jiemin; Xu, Ziwei; Qi, Yuan; Wu, Yueru

2017-08-01

The determination of area-averaged evapotranspiration (ET) at the satellite pixel scale/model grid scale over a heterogeneous land surface plays a significant role in developing and improving the parameterization schemes of the remote sensing based ET estimation models and general hydro-meteorological models. The Heihe Watershed Allied Telemetry Experimental Research (HiWATER) flux matrix provided a unique opportunity to build an aggregation scheme for area-averaged fluxes. On the basis of the HiWATER flux matrix dataset and high-resolution land-cover map, this study focused on estimating the area-averaged ET over a heterogeneous landscape with footprint analysis and multivariate regression. The procedure is as follows. Firstly, quality control and uncertainty estimation for the data of the flux matrix, including 17 eddy-covariance (EC) sites and four groups of large-aperture scintillometers (LASs), were carefully done. Secondly, the representativeness of each EC site was quantitatively evaluated; footprint analysis was also performed for each LAS path. Thirdly, based on the high-resolution land-cover map derived from aircraft remote sensing, a flux aggregation method was established combining footprint analysis and multiple-linear regression. Then, the area-averaged sensible heat fluxes obtained from the EC flux matrix were validated by the LAS measurements. Finally, the area-averaged ET of the kernel experimental area of HiWATER was estimated. Compared with the formerly used and rather simple approaches, such as the arithmetic average and area-weighted methods, the present scheme is not only with a much better database, but also has a solid grounding in physics and mathematics in the integration of area-averaged fluxes over a heterogeneous surface. Results from this study, both instantaneous and daily ET at the satellite pixel scale, can be used for the validation of relevant remote sensing models and land surface process models. Furthermore, this work will be

Nd Isotope and U-Th-Pb Age Mapping of Single Monazite Grains by Laser Ablation Split Stream Analysis

NASA Astrophysics Data System (ADS)

Fisher, C. M.; Hanchar, J. M.; Miller, C. F.; Phillips, S.; Vervoort, J. D.; Martin, W.

2015-12-01

Monazite is a common accessory mineral that occurs in medium to high grade metamorphic and Ca-poor felsic igneous rocks, and often controls the LREE budget (including Sm and Nd) of the host rock in which it crystallizes. Moreover, it contains appreciable U and Th, making it an ideal mineral for determining U-Th-Pb ages and Sm-Nd isotopic compositions, both of which are readily determined using in situ techniques with very high spatial resolution like LA-MC-ICPMS. Here, we present the results of laser ablation split stream analyses (LASS), which allows for simultaneous determination of the age and initial Nd isotopic composition in a single analysis. Analyses were done using a 20mm laser spot that allowed for detailed Nd isotope mapping of monazite grains (~30 analyses per ~250mm sized grain). Combined with LREE ratios (e.g., Sm/Nd, Ce/Gd, and Eu anomalies) these results yield important petrogenetic constraints on the evolution of peraluminous granites from the Old Woman-Piute batholith in southeastern California. Our findings also allow an improved understanding of the causes of isotope heterogeneity in granitic rocks. U-Th-Pb age mapping across the crystals reveals a single Cretaceous age for all grains with precision and accuracy typical of laser ablation analyses (~2%). In contrast, the concurrent Nd isotope mapping yields homogeneous initial Nd isotope compositions for some grains and large initial intra-grain variations of up to 8 epsilon units in others. The grains that yield homogeneous Nd isotope compositions have REE ratios suggesting that they crystallized in a fractionally crystallizing magma. Conversely, other grains, which also record fractional crystallization of both feldspar and LREE rich minerals, demonstrate a change in the Nd isotope composition of the magma during crystallization of monazite. Comparison of inter- and intra-grain Nd isotope compositions reveals further details on the potential mechanisms responsible for isotope heterogeneity

Contemporaneous migmitization and granite emplacement during regional metamorphism: Evidence for mid-crustal contribution to the batholiths of the Arabian-Nubian Shield

NASA Astrophysics Data System (ADS)

Elisha, B.; Katzir, Y.; Kylander-Clark, A. R.

2017-12-01

Collision-related granitoid batholiths, like those of the Hercynian and Himalayan orogens, are mostly fed by magma derived from meta-sedimentary sources. However, in the late Neoproterozoic calc-alkaline batholiths of the Arabian Nubian Shield (ANS), which constitutes the northern half of the East African orogen, sedimentary contribution is obscured by the juvenile character of the crust and the scarcity of migmatites. Here we use paired in-situ measurements of U-Th-Pb isotope ratios and REE contents of monazite and xenotime by LASS to demonstrate direct linkage between granites and migmatites in the northernmost ANS. Our results indicate a single prolonged period of monazite growth, 640-600 Ma, in metapelites, migmatites and peraluminous granites of the Abu-Barqa (SW Jordan), Roded (S Israel) and Taba-Nuweiba (Sinai, Egypt) metamorphic suites. Distribution of monazite dates and age zoning in single monazite grains in migmatites suggest that peak thermal conditions and partial melting prevailed for 10 Myr, from 620 to 610 Ma. REE patterns of monazite are well correlated with age, recording garnet growth and garnet breakdown in association with the prograde and retrograde stages of the melting reactions, respectively. Xenotime dates (n=40) cluster at 600-580 Ma recording retrogression to greenschist-facies conditions as garnet continues to destabilize. Phase equilibrium modelling and mineral thermobarometry illustrate that melting occurred either by dehydration of muscovite or by water-fluxed melting at 650-680° and 5-7 kbar. The expected melt production is 8-14%, allowing melt connectivity network to form and eventually melt extraction and segregation. The crystallization time of peritectic melt retained in dia- and metataxites overlaps the emplacement time of a vast calc-alkaline granitic flux throughout the northern ANS, which was previously considered post-collisional. Similar monazite ages ( 620 Ma) of the amphilolite-facies non-anatectic Elat schist indicate

Comments on the article entitled “Incompatibility of the Shuttleworth equation with Hermann’s mathematical structure of thermodynamics” by D.J. Bottomley, Lasse Makkonen and Kari Kolari [Surf. Sci. 603 (2009) 97

NASA Astrophysics Data System (ADS)

Hecquet, Pascal

2010-02-01

In the Shuttleworth's equation gij=γδij+dγ/dɛij, γ is the surface energy and gij is the surface stress with respect to the corresponding bulk quantity. At equilibrium and T=0 K, the bulk energy is the cohesive energy and the bulk stress is zero ( p=0). For i=j ( ɛii is hydrostatic) and for a flat surface, we show that the equilibrium surface stress gii corresponds to a surface pressure located mainly at the first monolayer and that the presence of the surface energy γ in the Shuttleworth's equation results from the matter conservation rule. Indeed, γ is an energy calculated per constant unit area while the atomic surface varies with the deformation as ( 1+ɛii). The equilibrium surface stress gii present at the surface is parallel to the surface. When gii is positive, this signifies that the surface atoms tend to contract together in the direction i even if the bulk pressure p is zero.

Impact of Ischemic and Valvular Heart Disease on Atrial Excitation:A High-Resolution Epicardial Mapping Study.

PubMed

Mouws, Elisabeth M J P; Lanters, Eva A H; Teuwen, Christophe P; van der Does, Lisette J M E; Kik, Charles; Knops, Paul; Yaksh, Ameeta; Bekkers, Jos A; Bogers, Ad J J C; de Groot, Natasja M S

2018-03-08

The influence of underlying heart disease or presence of atrial fibrillation (AF) on atrial excitation during sinus rhythm (SR) is unknown. We investigated atrial activation patterns and total activation times of the entire atrial epicardial surface during SR in patients with ischemic and/or valvular heart disease with or without AF. Intraoperative epicardial mapping (N=128/192 electrodes, interelectrode distances: 2 mm) of the right atrium, Bachmann's bundle (BB), left atrioventricular groove, and pulmonary vein area was performed during SR in 253 patients (186 male [74%], age 66±11 years) with ischemic heart disease (N=132, 52%) or ischemic valvular heart disease (N=121, 48%). As expected, SR origin was located at the superior intercaval region of the right atrium in 232 patients (92%). BB activation occurred via 1 wavefront from right-to-left (N=163, 64%), from the central part (N=18, 7%), or via multiple wavefronts (N=72, 28%). Left atrioventricular groove activation occurred via (1) BB: N=108, 43%; (2) pulmonary vein area: N=9, 3%; or (3) BB and pulmonary vein area: N=136, 54%; depending on which route had the shortest interatrial conduction time ( P <0.001). Ischemic valvular heart disease patients more often had central BB activation and left atrioventricular groove activation via pulmonary vein area compared with ischemic heart disease patients (N=16 [13%] versus N=2 [2%]; P =0.009 and N=86 [71%] versus N=59 [45%]; P <0.001, respectively). Total activation times were longer in patients with AF (AF: 136±20 [92-186] ms; no AF: 114±17 [74-156] ms; P <0.001), because of prolongation of right atrium ( P =0.018) and BB conduction times ( P <0.001). Atrial excitation during SR is affected by underlying heart disease and AF, resulting in alternative routes for BB and left atrioventricular groove activation and prolongation of total activation times. Knowledge of atrial excitation patterns during SR and its electropathological variations, as demonstrated in

Anatomy of an ancient subduction interface at 40 km depth: Insights from P-T-t-d data, and geodynamic implications (Dent Blanche, Western Alps)

NASA Astrophysics Data System (ADS)

Angiboust, Samuel; Glodny, Johannes; Oncken, Onno; Chopin, Christian

2014-05-01

interface exposed 200 km eastwards in eastern Switzerland (e.g. Bachmann et al., 2009). Our results shed light on deep (25-45 km) subduction zone structures and dynamics and are therefore of major interest for geophysical studies imaging the plate interface region in active subduction zones.

Melt Segregation and Tidal Heating at Io

NASA Astrophysics Data System (ADS)

Rajendar, A.; Dufek, J.; Roberts, J. H.; Paty, C. S.

2011-12-01

Recent evidence of melt beneath Io's surface (Khurana et al., 2010) and repeated observation of volcanic activity and features consistent with volcanic activity at the surface (e.g. Veeder et al, 1994; Rathbun et al., 2004; Lopes-Gautier et al., 1999; Smith et al., 1979) has raised further questions about the structure of the Galilean moon and the processes that shape it. In this study we examine the thermal state, melt fraction, and multiphase dynamics of melt segregation within Io's interior. Using a coupled multiphase dynamics and tidal heating model we explore the location, spatial extent, and temporal residence times of melt in Io's subsurface, as well as response to orbital parameters. In a thermally evolving body subject to tidal forcing, in which melt production and migration takes place, feedback can occur with respect to the physical and thermal properties. We explore this feedback to produce a thermal model of Io, taking into account the rate of tidal heating and fluid motion within the interior. First, a layered model of the internal structure is assumed. The equations of motion for forced oscillations in a layered spherical body are then solved using the propagator matrix method (Sabadini and Vermeesen, 2004) to obtain the displacements and strains due to tidal motion (Roberts and Nimmo, 2008). From this, the radial distribution of tidal heat generation within Io is calculated. This radial heating profile is then used as input for a multi-phase fluid model in order to obtain an estimate of the radial temperature distribution and thus the material properties and melt fractions. In the multiphase model individual phases (melt and solid residue) separately conserve mass, momentum and enthalpy (Dufek and Bachmann, 2010) allowing us to explore melt segregation phenomena. Enthalpy closure is provided by the MELTS (Ghiorso and Sack, 1995) thermodynamics algorithm, which is called at each point in space. This accounts for the partitioning between latent and

The Wall-Rock Record of Incremental Emplacement in the Little Cottonwood-Alta Magmatic and Hydrothermal System, Wasatch Mountains, Utah, U.S.A.

NASA Astrophysics Data System (ADS)

Stearns, M.; Callis, S.; Beno, C.; Bowman, J. R.; Bartley, J. M.

2017-12-01

Contact aureoles record the cumulative effects on wall rocks of magma emplacement. Like the plutons they surround, contact aureoles have long been regarded to form geologically instantaneously. Protracted incremental emplacement of plutons must be reconciled with the wall-rock record of heat and mass transfer. Fundamental questions include how heat and material move from intrusions into their aureoles and how long that process takes. The Little Cottonwood stock is surrounded by a 2 km-wide contact aureole that contains prograde AFM mineral assemblages in the pelitic layers of the Proterozoic Big Cottonwood Formation. The Alta stock is surrounded by a well characterized 1 km-wide contact aureole containing both prograde AFM and CMS mineral assemblages in Ophir Shale and Mississippian dolostones, respectively. Understanding the petrogenesis of these aureoles requires the timing of magmatism and wall-rock metamorphism to be independently determined. Preliminary petrochronology (U/Th-Pb dates and trace element concentrations collected by LASS-ICP-MS) from the inner aureoles of both intrusions establishes a protracted history of monazite (re)crystallization from 35-25 Ma in the Little Cottonwood aureole and 35 Ma in the Alta aureole. Little Cottonwood aureole monazites are characterized by a positive age correlation with heavy rare earth elements (HREE) and a negative correlation with Eu/Eu*. Alta aureole monazites have a similar range of the HREE concentrations and Eu/Eu* variation. Zircon growth interpreted to record emplacement-level magmatic crystallization of the western Little Cottonwood stock ranges from 33-28 Ma near the contact. Multi-grain U-Pb zircon TIMS dates from the Alta stock range from 35-33 Ma and are interpreted to suggest the full range of emplacement-level magmatism in the Alta stock. Additionally, in situ U-Pb titanite dates from the Alta stock record intermittent high temperature hydrothermal activity in the stock margin from 35-24 Ma. These new

The importance of intracrustal magmatic heat advection in large hot orogens: the Ediacaran-Cambrian ultrahigh-temperature domain of southern Madagascar.

NASA Astrophysics Data System (ADS)

Holder, R. M.; Hacker, B. R.

2016-12-01

Ultrahigh temperature metamorphism (UHTM) represents the thermal extremes of crustal metamorphism and is integral to our understanding of orogenic systems and continental evolution. The relative importance of advective and radiogenic heating in UHTM is often unclear, however, due to retrogression of UHT mineral assemblages and lack of robust chronology. We report the first observation of osumilite, pseudosections, feldspar thermometry, and monazite LASS U-Th-Pb chronology from the Ediacaran-Cambrian Anosyen domain of southern Madagascar to evaluate P-T-time paths and assess the relative importance of advective and radiogenic heating. Pseudosections of an osumilite-bearing assemblage, a garnet-orthopyroxene gneiss, and a garnet-spinel leucogneiss indicate peak conditions of 930-1010 C, 4-6 kbar; 900-950 C, 6-7 kbar; and 970-1000 C, 4.5-5.5 kbar, respectively. Feldspar thermometry indicates T > 915 ± 30 C. These conditions were reached along a low-P prograde path, as implied by cordierite and sillimanite inclusions in garnet. Monazite and zircon U/Th-Pb dating indicates that prograde metamorphism began 625 Ma and lasted 60 Myr. The timing of peak metamorphism is constrained to a 16 ± 2.5 Myr period between 566 ± 2 and 550 ± 1.5 Ma, by monazite inclusions in pseudomorphs after osumilite and monazite from a leucosome in the same outcrop. Peak T was achieved immediately following emplacement of voluminous charnockites (emplaced 1000-1100 C) and related magmas of the Anosyen Batholith. Crystallization of pegmatite dikes, leucosomes, and smaller plutons during cooling lasted from 550 to 510 Ma. This broad thermal history is also recorded by metamorphic monazite Eu/Eu*, which indicate progressive melt generation and extraction prior to 550 Ma followed by melt accumulation and crystallization after 550 Ma. Although the duration of prograde metamorphism is consistent with radiogenic heating models of large hot orogens, peak T was 100-200 C higher in southern Madagascar

Engineering and Scientific Applications: Using MatLab(Registered Trademark) for Data Processing and Visualization

NASA Technical Reports Server (NTRS)

Sen, Syamal K.; Shaykhian, Gholam Ali

2011-01-01

MatLab(R) (MATrix LABoratory) is a numerical computation and simulation tool that is used by thousands Scientists and Engineers in many cou ntries. MatLab does purely numerical calculations, which can be used as a glorified calculator or interpreter programming language; its re al strength is in matrix manipulations. Computer algebra functionalities are achieved within the MatLab environment using "symbolic" toolbo x. This feature is similar to computer algebra programs, provided by Maple or Mathematica to calculate with mathematical equations using s ymbolic operations. MatLab in its interpreter programming language fo rm (command interface) is similar with well known programming languag es such as C/C++, support data structures and cell arrays to define c lasses in object oriented programming. As such, MatLab is equipped with most ofthe essential constructs of a higher programming language. M atLab is packaged with an editor and debugging functionality useful t o perform analysis of large MatLab programs and find errors. We belie ve there are many ways to approach real-world problems; prescribed methods to ensure foregoing solutions are incorporated in design and ana lysis of data processing and visualization can benefit engineers and scientist in gaining wider insight in actual implementation of their perspective experiments. This presentation will focus on data processing and visualizations aspects of engineering and scientific applicati ons. Specifically, it will discuss methods and techniques to perform intermediate-level data processing covering engineering and scientifi c problems. MatLab programming techniques including reading various data files formats to produce customized publication-quality graphics, importing engineering and/or scientific data, organizing data in tabu lar format, exporting data to be used by other software programs such as Microsoft Excel, data presentation and visualization will be discussed. The presentation will emphasize creating

The Digital Distribution of Public Health News Surrounding the Human Papillomavirus Vaccination: A Longitudinal Infodemiology Study

PubMed Central

Tang, Tang; Ji, Kai; Ulrich-Schad, Jessica

2015-01-01

Background New media changes the dissemination of public health information and misinformation. During a guest appearance on the Today Show, US Representative Michele Bachmann claimed that human papillomavirus (HPV) vaccines could cause “mental retardation”. Objective The purpose of this study is to explore how new media influences the type of public health information users access, as well as the impact to these platforms after a major controversy. Specifically, this study aims to examine the similarities and differences in the dissemination of news articles related to the HPV vaccination between Google News and Twitter, as well as how the content of news changed after Michele Bachmann’s controversial comment. Methods This study used a purposive sampling to draw the first 100 news articles that appeared on Google News and the first 100 articles that appeared on Twitter from August 1-October 31, 2011. Article tone, source, topics, concerns, references, publication date, and interactive features were coded. The intercoder reliability had a total agreement of .90. Results Results indicate that 44.0% of the articles (88/200) about the HPV vaccination had a positive tone, 32.5% (65/200) maintained a neutral tone, while 23.5% (47/200) presented a negative tone. Protection against diseases 82.0% (164/200), vaccine eligibility for females 75.5% (151/200), and side effects 59.0% (118/200) were the top three topics covered by these articles. Google News and Twitter articles significantly differed in article tone, source, topics, concerns covered, types of sources referenced in the article, and uses of interactive features. Most notably, topic focus changed from public health information towards political conversation after Bachmann’s comment. Before the comment, the HPV vaccine news talked more often about vaccine dosing (P<.001), duration (P=.005), vaccine eligibility for females (P=.03), and protection against diseases (P=.04) than did the later pieces. After the

Acquiring Comprehensive Observations using an Integrated Sensorweb for Early Warning

NASA Technical Reports Server (NTRS)

Habib, Shahid; Ambrose, Steve

2006-01-01

As an integrated observing strategy, the concept of sensorweb for Earth observations is appealing in many aspects. For instance, by increasing the spatial and temporal coverage of observations from space and other vantage points, one can eventually aid in increasing the accuracy of the atmospheric models which are precursor to hurricane track prediction, volcanic eruption forecast, and trajectory path of transcontinental transport of dust, harmful nuclear and chemical plumes. In reality, there is little analysis'available in terms of benefits, costs and optimized set of sensors needed to make these necessary observations. This is a complex problem that must be carefully studied and balanced over many boundaries such as science, defense, early warning security, and surveillance. Simplistically, the sensorweb concept from the technological point of view alone has a great appeal in the defense, early warning and security applications. In fact, it can be relatively less expensive in per unit cost as opposed to building and deploying it for the scientific use. However, overall observing approach should not be singled out and aligned somewhat . orthogonally to serve a particular need. On the other hand, the sensorweb should be designed and deployed to serve multiple subject areas and customers simultaneously; and can behave as directed measuring systems for both science and operational entities. Sensorweb can be designed to act as expert systems, and/or also provide a dedicated integrated surveillance network. Today, there is no system in the world that is fully integrated in terms of reporting timely multiple hazards warnings, computing the lass of life and property damage estimates, and is also designed to cater to everyone's needs. It is not an easier problem to undertake and more so is not practically solvable. At this time due to some recent events in the world, the scientific community, social scientists, and operational agencies are more cognizant and getting

Photovoltaic reciprocity and quasi-Fermi level splitting in nanostructure-based solar cells (Conference Presentation)

NASA Astrophysics Data System (ADS)

Aeberhard, Urs

2017-04-01

Uwe Rau. Reciprocity between electroluminescence and quantum efficiency used for the characterization of silicon solar cells. Prog. Photovolt: Res. Appl., 17(6):394-402, 2009. [5] U. Hoyer, M. Wagner, Th. Swonke, J. Bachmann, R. Auer, A. Osvet, and C. J. Brabec. Electroluminescence imaging of organic photovoltaic modules. Appl. Phys. Lett., 97(23), 2010. [6] U. Aeberhard. Theory and simulation of quantum photovoltaic devices based on the non-equilibrium Greens function formalism. J. Comput. Electron., 10:394-413, 2011. [7] U. Aeberhard. Simulation of ultrathin solar cells beyond the limits of the semiclassical bulk picture. IEEE J. Photovolt., 6(3):654-660, 2016.

The Assembly and Emplacement of the Mushy Magma Model: A Historical Perspective

NASA Astrophysics Data System (ADS)

Bergantz, G. W.

2012-12-01

geometrical and source relationship between crystal poor and subjacent crystal rich mush. Lastly, it was appreciated that the boundary layer fluid dynamic models lacked geological verisimilitude, and invoked assumptions on heat transfer rates that were not in accord with geological conditions. Taken together this required a new conceptual model that could honor a broader range of constraints, and led to the 'full chamber' mush model as described by Hildreth (2001, 2004, 2007) and subsequently Bachmann and Bergantz (2004, 2008). However there are many open questions about this model, particularly how they are assembled, the physics of melt movement and mixing, and the way they respond to open system events. For example it is now recognized that crystal mushes can be remobilized rapidly and mineral isotopic and trace element zoning requires that the mush can go through some re-melting, consistent with the unzipping model of Burgisser and Bergantz (2011).

Lost in Translation

NASA Astrophysics Data System (ADS)

Lass, Wiebke; Reusswig, Fritz

2014-05-01

Lost in Translation? Introducing Planetary Boundaries into Social Systems. Fritz Reusswig, Wiebke Lass Potsdam Institute for Climate Impact Research, Potsdam, Germany Identifying and quantifying planetary boundaries by interdisciplinary science efforts is a challenging task—and a risky one, as the 1972 Limits to Growth publication has shown. Even if we may be assured that scientific understanding of underlying processes of the Earth system has significantly improved since then, the challenge of translating these findings into the social systems of the planet remains crucial for any kind of action, and in many respects far more challenging. We would like to conceptualize what could also be termed a problem of coupling social and natural systems as a nested set of social translation processes, well aware of the limited applicability of the language-related translation metaphor. Societies must, first, perceive these boundaries, and they have to understand their relevance. This includes, among many other things, the organization of transdisciplinary scientific cooperation. They will then have to translate this understood perception into possible actions, i.e. strategies for different local bodies, actors, and institutional settings. This implies a lot of 'internal' translation processes, e.g. from the scientific subsystem to the mass media, the political and the economic subsystem. And it implies to develop subsystem-specific schemes of evaluation for these alternatives, e.g. convincing narratives, cost-benefit analyses, or ethical legitimacy considerations. And, finally, societies do have to translate chosen action alternatives into monitoring and evaluation schemes, e.g. for agricultural production or renewable energies. This process includes the continuation of observing and re-analyzing the planetary boundary concept itself, as a re-adjustment of these boundaries in the light of new scientific insights cannot be excluded. Taken all together, societies may well

Ediacaran ( 620 Ma) high grade regional metamorphism in the northern Arabian Nubian Shield: U/Th-Pb monazite ages of the Elat schist

NASA Astrophysics Data System (ADS)

Elisha, Bar; Katzir, Yaron; Kylander-Clark, Andrew

2017-04-01

Ediacaran times witnessed a hemisphere-scale orogenesis forming the extensive Pan-African mountain ranges and resulting in the final assembly of Gondwana supercontinent. The Elat metamorphic basement (S Israel) located at the northernmost tip of a major Pan-African orogenic suture, the Arabian Nubian Shield (ANS), comprises amphibolite facies schists and gneisses and was most likely shaped by this major continental collision. However the timing, number and duration of metamorphic events in Elat and elsewhere in the ANS are non-conclusive and a major emphasis was given to pre-Ediacaran island-arc related tectonics. This is mostly because U-Pb dating of zircon, widely used in Elat and elsewhere, is very successful in constraining the ages of the igneous and sedimentary protoliths, but is 'blind' to metamorphism at grades lower than granulite. Here U/Th-Pb dating of monazite, a precise chronometer of metamorphic mineral growth, is systematically applied to the Elat schist and unveils the tectono-metamorphic evolution of the Elat basement. Previous U-Pb dating of detrital zircon has shown that the sedimentary protoliths of the Elat schist are the oldest basement components (≥800 Ma), and detailed structural observations of the schists portrayed a complex deformation history including four successive phases (Shimron, 1972). The earliest three phases were defined as ductile and penetrative, but some of the available geochronological data apparently contradict field relations. In-situ analysis of metamorphic monazites by LASS (Laser Ablation Split Stream) involves simultaneous measurement of U/Th-Pb isotope ratios and REE contents in a single 10 μm sized grain or domain, thus allowing determining the age of specific texture and metamorphic assemblage. Monazite dating of the Elat schist yielded two concordant age clusters at 712±6 and 613±5 Ma. The corresponding REE patterns of the dated monazite grains indicate that porphyroblast growth, either garnet or staurolite

Micromechanics of Spray-On Foam Insulation

NASA Technical Reports Server (NTRS)

Bednarcyk, Brett A.; Aboudi, Jacob; Arnold, Steven M.; Sullivan, Roy M.

2007-01-01

Understanding the thermo-mechanical response of the Space Shuttle External Tank spray-on foam insulation (SOFI) material is critical, to NASA's Return to Flight effort. This closed-cell rigid polymeric foam is used to insulate the metallic Space Shuttle External Tank, which is at cryogenic temperatures immediately prior to and during lift off. The shedding of the SOFI during ascent led to the loss of the Columbia, and eliminating/minimizing foam lass from the tank has become a priority for NASA as it seeks to resume scheduled space shuttle missions. Determining the nature of the SOFI material behavior in response to both thermal and mechanical loading plays an important role as any structural modeling of the shedding phenomenon k predicated on knowledge of the constitutive behavior of the foam. In this paper, the SOFI material has been analyzed using the High-Fidelity Generalized Method of Cells (HFGMC) micromechanics model, which has recently been extended to admit a triply-periodic 3-D repeating unit cell (RUC). Additional theoretical extensions that mere made in order to enable modeling of the closed-cell-foam material include the ability to represent internal boundaries within the RUC (to simulated internal pores) and the ability to impose an internal pressure within the simulated pores. This latter extension is crucial as two sources contribute to significant internal pressure changes within the SOFI pores. First, gas trapped in the pores during the spray process will expand or contract due to temperature changes. Second, the pore pressure will increase due to outgassing of water and other species present in the foam skeleton polymer material. With HFGMC's new pore pressure modeling capabilities, a nonlinear pressure change within the simulated pore can be imposed that accounts for both of these sources, in addition to stmdar&-thermal and mechanical loading; The triply-periodic HFGMC micromechanics model described above was implemented within NASA GRC's MAC

Tracking the evolution of a giant magmatic system from assembly to supereruption

NASA Astrophysics Data System (ADS)

Wotzlaw, J. F.; Schaltegger, U.; Frick, D. A.; Dungan, M. A.; Gerdes, A.; Günther, D.

2012-12-01

apparent crystallinity that is ~30% higher than at the time of eruption, implying that the Fish Canyon magma was perilously close to complete solidification, hence 'plutonic death', prior to late reheating. We estimate the duration of the reheating event from the age difference of the chemically most evolved (highest Yb/Dy) and the youngest dated zircon to be ~170 ka. This duration for reactivation of the near solidus crystal mush is in excellent agreement with estimates derived from numerical modeling of remelting by upward percolation of a hot gas-phase derived from underplated mafic magma ('gas sparging'; Bachmann and Bergantz, 2003, Geology). This investigation, which is the first in which high resolution U-Pb zircon geochronology has been coupled with geochemical modeling of systematic compositional variations in an accessory mineral, ties together many of the threads which have been developed independently during previous studies of the Fish Canyon magmatic system and places related petrogenetic processes into an absolute time frame.

Is there excess argon in the Fish Canyon magmatic system?

NASA Astrophysics Data System (ADS)

Wilkinson, C. M.; Sherlock, S.; Kelley, S. P.; Charlier, B. L.

2010-12-01

interfering peaks at mass 36 allowing us to correct for the atmospheric 40Ar content. By using this method to analyse potassium-rich minerals (sanidine and biotite) and potassium-poor minerals (quartz and plagioclase), it has been possible to study the distribution of argon within these mineral phases and its incorporation into melt, fluid and solid inclusions. Here we report new 40Ar/39Ar intra-grain age data of minerals from the Fish Canyon Tuff, which despite being well characterised and extensively researched has not yet been a subject for this particular technique. [1] Renne P. R. et al., (2010) Geochim. Cosmochim. Acta, 74, 5349-5367. [2] Bachmann, O. et al., (2007) Chemical Geology, 236, 134-166.[3] Charlier, B.L.A. et al., (2007) Journal of Petrology, 48, 1875-1894. [4] Esser, R. P. et al., (1997) Geochim. Cosmochim. Acta, 61, 3789-3801. [5] Kelley, S. (2002) Chemical Geology, 188, 1-22. Corresponding Author: c.m.wilkinson@open.ac.uk

Large Early Permian eruptive complexes in northern Saxony, Germany: Volcanic facies analysis and geochemical characterization

NASA Astrophysics Data System (ADS)

Hübner, Marcel; Breitkreuz, Christoph; Repstock, Alexander; Heuer, Franziska

2017-04-01

calculations based on composition of pyroxene and feldspar suggest deeply seated crustal magma chambers for the NSVC and the Planitz ignimbrite. Fischer, F. (1991): Das Rotliegende des ostthüringisch-westsächsischen Raumes (Vorerzgebirgs-Senke, Nordwestsächsischer Vulkanitkomplex, Geraer Becken). Unpublished PhD thesis, TU Bergakademie Freiberg. HILDRETH, W. (1981): Gradients in silicic magma chambers: Implications for lithospheric magmatism. Journal of Geophysical Research (86), p. 10153-10192. Hoffmann, U.; Breitkreuz, C.; Breiter, K.; Sergeev, S.; Stanek, K.; Tichomirowa, M. (2013): Carboniferous-Permian volcanic evolution in Central Europe - U/Pb ages of volcanic rocks in Saxony (Germany) and northern Bohemia (Czech Republic). Int. J. Earth Sci. (Geol. Rdsch.), 102: p. 73-99. Huber, C.; Bachmann, O.; Dufek, J. (2012): Crystal-poor versus crystal-rich ignimbrites: A competition between stirring and reactivation. Geology, 2 (40), p. 115-118. Mason, B. G., Pyle, D. M. & Oppenheimer, C. (2004): The size and frequency of the largest explosive eruptions on Earth. Bull. Volcanology, 66, p. 735-748. Schneider, J.W.; Rößler, R.; Fischer, F. (2012): Rotliegend des Chemnitz-Beckens (syn. Erzgebirge-Becken). - In: Deutsche Stratigraphische Kommission (Ed.): Stratigraphie von Deutschland X. Rotliegend. Teil I: Innervariscische Becken. Schriftenreihe der Deutschen Gesellschaft für Geowissenschaften, Heft 61: pp. 530-588; Hannover. Walter, H. (2006): Das Rotliegend der Nordwestsächsischen Senke. Veröff. Museum Naturkunde, 29, p. 157-176.

What do large scale studies of medication in schizophrenia add to our management strategies?

PubMed

Agius, Mark; Davis, Abigail; Gilhooley, Michael; Chapman, Shelley; Zaman, Rashid

2010-06-01

used, which were reflected in their differing rates of efficacy. * CUtLASS This trial allows for less generalisation of its findings to the general population as it makes use a specific sub-population (those switching from one medication to another after a period of treatment). Also some patients were prescribed oral medications and some depot injections - making comparisons difficult due to possible differences in compliance. * EUFEST This trial makes use of discontinuation as an endpoint with the weaknesses we have described. Treatment of first episodes of psychosis is shown to be feasible, but it could not suggest if haloperidol or second generation drugs may be more efficacious. * SOHO - This trial hindered by the observational design of the study and small numbers reaching the primary end point (4%) caution should be exercised in the conclusion that olanzapine is superior to risperidone, quetiapine or typical antipsychotics. There is much information useful for clinical practice to be gathered from the results of these major studies, however, interpretation is hampered by both variations and weakness in study design. On balance it does appear that different antipsychotics possess differing efficacy, but also of relevance to the development of sound clinical guidelines is their differing side effects profile.

Two-Stage Magma Mixing and Initial Phase of the 1667 Plinian Eruption of Tarumai Volcano

NASA Astrophysics Data System (ADS)

Tomiya, A.; Takeuchi, S.

2009-12-01

Plinian eruptions can eject high-viscosity low-T magma with high crystal content. Several mechanisms have been proposed, such as remobilization by addition of volatile from high-T magma (Bachmann & Bergantz, 2006) and precursory eruption of low-viscosity hybrid magma between low-T and high-T magmas (Pallister et al., 1996; Takeuchi & Nakamura, 2001). We discuss this matter by analysis on a Plinian eruption of Tarumai Volcano. Tarumai (Tarumae) is one of the most active volcanoes in Japan. The 1667 eruption is the first one in historical time after thousands of years of dormancy, and one of the largest eruptions (VEI 5) in the volcano (Soya & Sato, 1980). The major eruptive product, Ta-b pumice, is andesite, consisting of abundant phenocrysts (20-40 %) and rhyolitic glass (Soya, 1971; Furukawa, 1998; Nakagawa et al., 2006). Hiraga & Nakagawa (2000) reported that the bulk rock was homogeneous (SiO2 = 58-62 wt.%) from subunit b8 (lower) to b1 (upper). On the other hand, Takeuchi (2001) found that the bottom layer of b8 (b8-bottom) was more mafic (SiO2 = 56-58 wt.%) and interpreted it as precursory hybrid magma. We analyzed phenocrysts in b8-bottom and other subunits of Ta-b, and compared their compositions and textures. The followings are obtained. Plagioclase: the compositions and textures are similar among the subunits; some phenocrysts are calcic with a homogeneous core of An > 90, whereas most have a complex texture with An 65 to 75. Orthopyroxene/clinopyroxene: the compositions and textures are similar among the subunits; most phenocrysts have a homogeneous core of Mg* 62 to 68 for orthopyroxene and Mg* 70 to 74 for clinopyroxene; those in b8-bottom show reverse zonings. Olivine: there are few phenocrysts and they often coexist with the calcic plagioclase. Magnetite: the compositions are homogeneous (Usp 30 to 34, Mg/Mn 5 to 7; type-1) except for those in b8-bottom; there are two types of phenocrysts in b8-bottom, Usp 30 to 34, Mg/Mn 7 to 9 (type-2) and Usp 23 to

Sphene (Titanite) as Both Monitor and Driver of Evolution of Felsic Magma: Miocene Volcanic Plutonic and Rocks of the Colorado River Region, NV-AZ, USA

NASA Astrophysics Data System (ADS)

Miller, C. F.; Colombini, L. L.; Wooden, J. L.; Mazdab, F. K.; Gualda, G. A.; Claiborne, L. E.; Ayers, J. C.

2009-05-01

phenocryst- poor whole rocks are very high, especially for middle REE: LREE Kds ca. 50-100, MREE ~500-600 (Eu ca. 300- 400), HREE ca. 100. Late REE fractionation trends that are evident in both plutonic and volcanic sequences are clearly controlled for the most part by sphene: aplites, some leucogranites, and high-Si rhyolite whole rocks and glasses reveal extreme MREE depletion and suppressed development of Eu anomalies, a trend that is also expressed in core-to-rim REE depletion patterns in sphene crystals. Results suggest that sphene saturation in these magmas occurred in melts that were already evolved but that it had a dramatic effect on final stages of fractionation. The sphene 'fingerprint' is similar to that proposed by Glazner et al. (Geology 36:183 2008) for Sierra Nevada aplites and as they suggest it marks a late-stage process, but in contrast to their inference we demonstrate that it is evident in volcanic as well as comagmatic plutonic rocks. A better understanding of the controls of sphene saturation will lead to refined interpretation of its presence (or absence), onset of growth, and geochemical fingerprint with respect to magmatic-tectonic environments (cf. Bachmann & Bergantz JPet 49:2277 2008). We intend to address these issues further with saturation experiments and tomographic and geochemical studies of sphene and its inclusions and associated phases.

Minimum reporting standards for copers in chronic ankle instability research.

PubMed

Wikstrom, Erik A; Brown, Cathleen N

2014-02-01

Lateral ankle sprains (LASs) are among the most common sports-related injuries and a high percentage of individuals who sprain their ankle go on to develop chronic ankle instability (CAI). The condition of CAI is often classified as having pain, loss of function, and a restriction of, or failure to, return to levels of previous activity. Historically, uninjured healthy controls are used as a comparison group to study the biomechanical and neuromuscular consequences of CAI. However, this model is not ideal to determine why a portion of the population experiencing an ankle sprain does not recover. A more appropriate comparison may be individuals who had an ankle sprain, and thus the exposure, but did not go on to develop CAI (i.e., copers). Thus, the purpose of this review was to determine the existing discrepancies and common standards in definitions of, terminology used for, and the inclusionary/exclusionary criteria used to describe copers within the CAI literature. Multiple databases were searched by keywords and specific authors. Potential studies were screened independently by both authors. Inclusion criteria consisted of an explicit definition of copers and explicit inclusionary/exclusionary criteria. A total of 21 studies were included in the current study and had four outcomes extracted: (1) the definition of copers; (2) the terminology used; (3) specific inclusionary/exclusionary criteria; and (4) injury characteristics of the copers. Based on the included operational definitions, it is recommend that future operational definitions of copers include three key components: (1) an initial LAS; (2) subsequent lack of CAI symptoms (i.e., no complaints of disability or giving way); and (3) a time since injury component. The term coper was overwhelming used within the existing literature (n = 15) and is thus recommended to be used in future studies when describing individuals who have suffered an LAS but failed to develop CAI. Minimal inclusionary criteria should

EDITORIAL: The 24th Nordic Semiconductor Meeting The 24th Nordic Semiconductor Meeting

NASA Astrophysics Data System (ADS)

Páll Gunnlaugsson, Haraldur; Nylandsted Larsen, Arne; Uhrenfeldt, Christian

2012-03-01

AndersenAalborg University, Aalborg, Denmark Pia BomholtAarhus University, Aarhus, Denmark Hafliði P GíslasonUniversity of Iceland, Reykjavik, Iceland Haraldur Páll GunnlaugssonAarhus University, Aarhus, Denmark John HansenAarhus University, Aarhus, Denmark Britta JohansenAarhus University, Aarhus, Denmark Volodymyr KhranovskyyLinköping University, Linköping, Sweden Arne Nylandsted LarsenAarhus University, Denmark Helge MalmbekkUniversity of Oslo, Oslo, Norway Erik Stensrud MarsteinInstitute for Energy Technology, Kjeller, Norway Antonio MartiUniversidad Politécnica de Madrid, Madrid, Spain Torben MølholtUniversity of Iceland, Reykjavik, Iceland Sveinn ÓlafssonUniversity of Iceland, Reykjavik, Iceland Thomas PedersenTechnical University of Denmark, Kgs. Lyngby, Denmark Thomas Garm PedersenAalborg University, Aalborg, Denmark Dirch Hjorth PetersenTechnical University of Denmark, Kgs. Lyngby, Denmark Vincent QuemenerUniversity of Oslo, Oslo, Norway Henry RadamsonKTH Royal Institute of Technology, Kista, Sweden Bahman RaeissiUniversity of Oslo, Oslo, Norway Jonatan SlotteAalto University, Aalto, Finland Xin SongUniversity of Oslo, Oslo, Norway Einar Örn SveinbjörnssonUniversity of Iceland, Reykjavik, Iceland Mikael SyväjärviLinköping University, Linköping, Sweden Chi Kwong TangUniversity of Oslo, Oslo, Norway Erik V ThomsenTechnical University of Denmark, Kgs. Lyngby, Denmark Christian UhrenfeldtAarhus University, Aarhus, Denmark Hans Ulrik UlriksenAalborg University, Aalborg, Denmark Muhammad UsmanKTH Royal Institute of Technology, Kista, Sweden Lasse VinesUniversity of Oslo, Oslo, Norway Ulrich WahlUnidade de Física e Aceleradores, Sacavém, Portugal Helge WemanNTNU, Trondheim, Norway Gerd WeyerAarhus University, Denmark

Water Quality and Hydrology of Whitefish (Bardon) Lake, Douglas County, Wisconsin, With Special Emphasis on Responses of an Oligotrophic Seepage Lake to Changes in Phosphorus Loading and Water Level

USGS Publications Warehouse

Robertson, Dale M.; Rose, William J.; Juckem, Paul F.

2009-01-01

average annual load of phosphorus to the lake was 232 pounds: 56 percent from precipitation, 27 percent from groundwater, and 16 percent from septic systems. During a series of dry years (low water levels) and wet years (high water levels), the inputs of water and phosphorus ranged by only 10-13 percent. Results from the Canfield and Bachmann eutrophication model and Carlson trophic-state-index equations demonstrated that the lake directly responds to changes in external phosphorus loading, with percent change in chlorophyll a being similar to the percent change in loading and the change in total phosphorus and Secchi depth being slightly smaller. Therefore, changes in phosphorus loading should affect the water quality of the lake. Specific scenarios that simulated the effects of anthropogenic (human-induced) and climatic (water level) changes demonstrated that: surface-water inflow (runoff) based on current development has little effect on pelagic water quality, changes in the inputs from septic systems and development in the watershed could have a large effect on water quality, and decreases in water and phosphorus loading during periods of low water level had little effect on water quality. Sustained high water levels, resulting from several wet years with relatively high water and phosphorus input, however, could cause a small degradation in water quality. Although high water levels may be associated with a degradation in water quality, it appears that anthropogenic changes in the watershed may be more important in affecting the future water quality of the lake. Fluctuations in water levels since 1998 are representative of what has occurred since 1900, with fluctuations of about 3 feet occurring about every 15 years. Based on total phosphorus concentrations inferred from sediment core analysis, there has been little long-term change in water quality and there has been a slight deterioration in water quality following most periods of high water levels. There

Convective melting in a magma chamber: theory and numerical experiment.

NASA Astrophysics Data System (ADS)

Simakin, A.

2012-04-01

conditions for the intruded magma to crystallize first and then switch to the roof melting or only crystallize were not defined. We did this in our numerical experiments in terms of the initial magma and roof rocks temperatures for particular sill size. Neglecting strong viscosity variation in the boundary layer at the melting front leads to the overestimation of the melting rate by H&S model on approximately 70% at Tm=940oC. At Tm =800oC effect of the crystals present in descending plumes compensates viscosity increase and numerical Um practically coincides with theoretical one (difference 8%). Some researchers (Huber et al., 2010) use empirical and scaling results obtained from stagnant-lid convection (Davaille and Jaupart, 1993). We find that the later model is not applicable to the melting problem since super-exponential dependence of the viscosity from temperature is valid providing full solidification below eutectic temperature Ts. "Melting temperature" at the stagnant-lid style of convection is defined by Arhenius rheological parameters and bulk melt temperature and can be less than Ts. Our numerical study was applied to the estimation of the possible time frame and efficiency of the remelting of the silicic pyroclastics by superheated rhyolites in the caldera environment (Simakin and Bindeman, 2012). Literature. 1)Davaille, A. and Jaupart, C. (1993) J. Fluid. Mech., 253: 141-166. 2) Huppert, H.E. and Sparks, R.S.J. (1988) J. Petrol., 29: 599-624. 3)Huber, C., Bachmann, O., Dufek, J. (2010) J. Volcanol. Geotherm. Res., 195: 97-105. 4)Jaupart, C. and Brandeis, G. (1986) Earth Planet. Sci. Lett. 80: 183-199. 5)Simakin, A.G. and Bindeman, I.N. (2012) Remelting in caldera and rift environments and the genesis of hot, "recycled" rhyolites. Earth Planet. Sci. Lett. (in review). 6) Snyder, D. (2000) Earth Planet. Sci. Lett. 175: 257-273.

Stakeholder perception about urban sprawl impacts in land degradation in Lithuania. The importance of profession and education.

NASA Astrophysics Data System (ADS)

Pereira, Paulo; Misiune, Ieva; Mierauskas, Pranas; Depellegrin, Daniel

2016-04-01

.1002/ldr.2290 Pereira, P., Monkevicius, A., Siarova, A. (2014) Public perception of environmental, social and economic impacts of urban sprawl in Vilnius. Societal Studies, 6, 259-290. Schwilch, G., Bachmann, F., Liniger, H.P. (2009) Appraising and selecting conservation measures to mitigate desertification and land degradation based on stakeholder participation and best practices. Land Degradation and Development, 20, 308-326. Subiros, J.V., Rodriguez-Carreras, R., Varga, D., Ribas, A., Ubeda, X., Aspero, F., Llausas, A., Outeiro, L. (2016) Stakeholders perceptions of landscape changes in the Mediterranean mointians of the North-Eastern Iberian Peninsula. Land Degradation and Development, DOI: 10.1002/ldr.2337

PREFACE: 17th International Conference on Textures of Materials (ICOTOM 17)

NASA Astrophysics Data System (ADS)

Skrotzki, Werner; Oertel, Carl-Georg

2015-04-01

related research on microstructures 9. Texture-induced anisotropy 10. Insight through new experimental methods 11. Technological applications of texture studies 12. Other new developments and future trends related to the field While there was large interest in the topics 2, 3 and 8, contributions to topic 7 were much less than expected. ICOTOM 17 attracted 266 scientists from 34 countries with about one third of the participants being students. This is a very good ratio showing that we could attract the young generation. There have been 216 oral and 76 poster presentations, three of which received a poster award. It is our pleasure to thank the members of the International ICOTOM Committee for their valuable help, especially for proposing and choosing the 15 plenary speakers as well as the distinguished scientist of the texture community for the "Bunge Award". 130 papers were submitted for publication in the proceedings, 116 were accepted after reviewing. We would like to express our thanks to all referees for their efficient and prompt efforts. We acknowledge particularly support from the German Research Society (DFG) and the City of Dresden. We are also grateful for industrial support from Bruker Nano GmbH, Oxford Instruments GmbH, Ametek GmbH / EDAX, Labosoft S.C., PANalytical GmbH and IOP Publishing. Finally we thank all members of the National Organizing Committee, Intercom Dresden and Conwerk / Laboratory Ten for the excellent organization of ICOTOM 17 and the very pleasant collaboration. On the first day of the conference three tutorials have been offered. Each of them has been attended by about 30 participants. 1. Texture-aided residual stress identification system (TARSIuS) (organized by Prof. Dr. J. Bonarski and Mr. B. Kania) 2. MTEX - MATLAB toolbox for quantitative texture analysis (organized by Dr. R. Hielscher and Mr. F. Bachmann) 3. Grain boundary engineering (organized by Prof. N. Bozzolo and Prof. Dr. A.D. Rollett) A highlight of ICOTOM 17 was the

Archaeological Geophysics in Israel: Past, Present and Future

NASA Astrophysics Data System (ADS)

Eppelbaum, L. V.

2009-04-01

et al., 1999; Reeder et al., 2004; Reinhardt et al., 2006; Reich et al., 2003; Ron et al., 2003; Segal et al., 2003; Sternberg and Lass, 2007; Sternberg et al., 1999; Verri et al., 2004; Weiner et al., 1993; Weinstein-Evron et al., 1991, 2003; Weiss et al., 2007; Witten et al., 1994), and (3) future [2010 -]. The past stage with several archaeoseismic reviews and very limited application of geophysical methods was replaced by the present stage with the violent employment of numerous geophysical techniques (first of all, high-precise magnetic survey and GPR). It is supposed that the future stage will be characterized by extensive development of multidiscipline physical-archaeological databases (Eppelbaum et al., 2009b), utilization of supercomputers for 4D monitoring and ancient sites reconstruction (Foster et al., 2001; Pelfer et al., 2004) as well as wide application of geophysical surveys using remote operated vehicles at low altitudes (Eppelbaum, 2008a). REFERENCES Batey, R.A., 1987. Subsurface Interface Radar at Sepphoris, Israel 1985. Journal of Field Archaeology, 14 (1), 1-8. Bauman, P., Parker, D., Coren, A., Freund, R., and Reeder, P., 2005. Archaeological Reconnaissance at Tel Yavne, Israel: 2-D Electrical Imaging and Low Altitude Aerial Photography. CSEG Recorder, No. 6, 28-33. Ben-Dor, E., Portugali, J., Kochavi, M., Shimoni, M., and Vinitzky, L., 1999. Airborne thermal video radiometry and excavation planning at Tel Leviah, Golan Heights, Israel. Journal of Field Archaeology, 26 (2), 117-127. Ben-Menahem, A., 1979. Earthquake catalogue for the Middle East (92 B.C. - 1980 A.D.). Bollettino di Geofisica Teorica ed Applicata, 21 (84), 245-310. Ben-Yosef, E., Tauxe, L., Ronb, H., Agnon, A., Avner, U., Najjar, M., and Levy, T.E., 2008. A new approach for geomagnetic archaeointensity research: insights on ancient metallurgy in the Southern Levant. Journal of Archaeological Science, 25, 2863-2879. Berkovitch, A.L., Eppelbaum, L.V., and Basson, U., 2000

Long-term water repellency in organic olive orchards in the Cànyoles River watershed. The impact of land management

NASA Astrophysics Data System (ADS)

Cerdà, Artemi; González Pelayo, Óscar; García Orenes, Fuensanta; Jordán, Antonio; Pereira, Paulo; Novara, Agata; Neris, Jonay

2015-04-01

., & Martí-Dalmau, C. 2014. Changes in water repellency, aggregation and organic matter of a mollic horizon burned in laboratory: soil depth affected by fire. Geoderma, 213, 400-407. Badía-Villas, D., González-Pérez, J. A., Aznar, J. M., Arjona-Gracia, B., & Martí-Dalmau, C. 2014. Changes in water repellency, aggregation and organic matter of a mollic horizon burned in laboratory: soil depth affected by fire. Geoderma, 213, 400-407. Bodí, M.B. Doerr, S.H., Cerdà, A., Mataix-Solera, J. 2012. Hydrological effects of a layer of vegetation ash on underlying wettable and water repellent soils. Geoderma, 191, 14-23. http://dx.doi.org/10.1016/j.geoderma.2012.01.006 Bodí, M.B., Muñoz-Santa, I., Armero, C., Doerr, S.H., Mataix-Solera, J., Cerdà, A. 2013. Spatial and temporal variations of water repellency and probability of its occurrence in calcareous Mediterranean rangeland soils affected by fires. Catena, 108, 14-24. http://dx.doi.org/10.1016/j.catena.2012.04.002 Dlapa, P., Bodí, M.B., Mataix-Solera, J., Cerdà, A., Doerr, S.H. 2013. FT-IR spectroscopy reveals that ash water repellency is highly dependent on ash chemical composition. Catena, 108, 35-43. Doi:10.1016/j.catena.2012.02.011 García-Moreno, J., Gordillo-Rivero, Á. J., Zavala, L. M., Jordán, A., & Pereira, P. 2013. Mulch application in fruit orchards increases the persistence of soil water repellency during a 15-years period. Soil and Tillage Research, 130, 62-68. García-Orenes, F., Roldán, A., Mataix-Solera, J., Cerdà, A., Campoy, M., Arcenegui, V., Caravaca, F. 2012 Soil structural stability and erosion rates influenced by agricultural management practices in a semi-arid Mediterranean agro-ecosystem. Soil Use and Management 28(4): 571-579. DOI: 10.1111/j.1475-2743.2012.00451.x Goebel, M. O., Bachmann, J., Reichstein, M., Janssens, I. A., Guggenberger, G. 2011. Soil water repellency and its implications for organic matter decomposition-is there a link to extreme climatic events?. Global Change Biology