Federal Information Resources for Professional Counselors. A Sourcebook of Free and Low-Cost Resources To Support and Enrich Your Work as a Professional Counselor.

ERIC Educational Resources Information Center

Lum, Christie

This publication is a sourcebook of free and low-cost resources to support the work of professional counselors. The information includes: (1) synthesis of current research, statistics, and research reports; (2) background material about current and emerging policy issues; (3) information about model programs and policies; (4) materials and…

Illuminating the Background: Topics in Cosmic Microwave Background Polarization Research

NASA Astrophysics Data System (ADS)

Miller, Nathan J.

The cosmic microwave background provides a wealth of information about the origin and history of the universe. The statistics of the anisotropy and the polarization of the cosmic microwave background, among other things, can tell us about the distribution of matter, the redshift of reionization, and the nature of the primordial uctuations. From the lensing of cosmic microwave background due to intervening matter, we can extract information about neutrinos and the equation of state of dark energy. A measurement of the large angular scale B-mode polarization has been called the "smoking gun" of in ation, a theory that describes a possible early rapid expansion of the universe. The focus of current experiments is to measure this B-mode polarization, while several experiments, such as POLARBEAR, are also looking to measure the lensing of the cosmic microwave background. This dissertation will discuss several different topics in cosmic microwave background polarization research. I will make predictions for future experiments and I will also show analysis for two current experiments, POLARBEAR and BICEP. I will show how beam systematics affect the measurement of cosmological parameters and how well we must limit these systematics in order to get unbiased constraints on cosmological parameters for future experiments. I will discuss a novel way of using the temperature-polarization cross correlation to constrain the amount of inflationary gravitational waves. Through Markov Chain Monte Carlo methods, I will determine how well future experiments will be able to constrain the neutrino masses and their degeneracy parameters. I will show results from current data analysis and calibration being done on the Cedar Flat deployment for the POLARBEAR experiment which is currently being constructed in the Atacama desert in Chile. Finally, I will analyze the claim of detection of cosmological birefringence in the BICEP data and show that there is reason to believe it is due to systematic effects in the data.

NASA/NSF Workshop on Antarctic Research

NASA Technical Reports Server (NTRS)

Connors, Mary M.

1990-01-01

Viewgraphs that accompanied an Ames Research Center presentation address Ames' currently-supported life sciences activities. These include crew factor issues such as human, automation, and telecommunication systems; strategic behavior and workloads; sleep, fatigue, and circadian rhythms; and virtual reality and spatial instrumentation. The need, background, and examples of pertinent research are provided.

Perceptual Judgments of Accented Speech by Listeners from Different First Language Backgrounds

ERIC Educational Resources Information Center

Kang, Okim; Vo, Son Ca Thanh; Moran, Meghan Kerry

2016-01-01

Research in second language speech has often focused on listeners' accent judgment and factors that affect their perception. However, the topic of listeners' application of specific sound categories in their own perceptual judgments has not been widely investigated. The current study explored how listeners from diverse language backgrounds weighed…

The Influence of Informal Music Education in Teacher Formation: An Autoethnography

ERIC Educational Resources Information Center

Nethsinghe, Rohan

2012-01-01

In this paper I explore how my musical background, teaching skills, understanding and knowledge as well as music-making abilities and skills, have formed my current self as musician, teacher and researcher. An autoethnographical method is used to investigate my background, including the different modes of music education I received. From this…

Classroom Instruction That Works, Second Edition: Research Report

ERIC Educational Resources Information Center

Beesley, Andrea D., Ed.; Apthorp, Helen S., Ed.

2010-01-01

Background: The current study updates and extends the original research synthesis of effective instructional strategies presented in "Classroom Instruction that Works" ("CITW"; Marzano, Pickering, & Pollock, 2001). That work identified nine instructional strategies for improving academic achievement and synthesized findings from previous…

Symposium: An Overview of the 5-Year Research Agenda for the Research & Training Center for Children's Mental Health.

ERIC Educational Resources Information Center

Friedman, Robert M.; Evans, Mary; Morrison-Rodriguez, Barbara; Kutash, Krista; Duchnowski, Al; Hernandez, Mario; Hodges, Sharon; Armstrong, Mary; Pires, Sheila; Stroul, Beth; Greenbaum, Paul; Brown, Eric; Lazear, Katherine

This paper describes each of eight current interrelated federally funded research projects conducted by the Research and Training Center for Children's Mental Health at the University of South Florida. For each project, information is provided on the project's background, purpose, methodology, and anticipated results. Project titles and principal…

The MAJORANA DEMONSTRATOR for 0νββ: Current Status and Future Plans

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, M. P.; Abgrall, N.; Aguayo, Estanislao

2015-03-24

The Majorana Demonstrator will search for neutrinoless-double-beta decay in 76Ge, while establishing the feasibility of a future tonne-scale germanium-based neutrinoless-double-beta decay experiment, and performing searches for new physics beyond the Standard Model. The experiment, currently under construction at the Sanford Underground Research Facility in Lead, SD, will consist of a pair of modular high-purity germanium detector arrays housed inside of a compact copper, lead, and polyethylene shield. Through a combination of strict materials qualifications and assay, low-background design, and powerful background rejection techniques, the Demonstrator aims to achieve a background rate in the neutrinoless-double-beta decay region of interest (ROI) ofmore » no more than 3cnts/(ROI-t-y). The current status of the Demonstrator is discussed, as are plans for its completion.« less

Child Abuse and Neglect: A Report on the Status of the Research.

ERIC Educational Resources Information Center

Hurt, Maure, Jr.

This state-of-the-art report provides preliminary information on the status of child abuse and neglect research projects currently in progress or recently completed. Each chapter discusses a particular research problem area and outlines the relevant demonstration projects. Chapter I describes the background of our present perception of child abuse…

Why We Need a Structured Abstract in Education Research

ERIC Educational Resources Information Center

Mosteller, Frederick; Nave, Bill; Miech, Edward J.

2004-01-01

Background: Approximately 1,100 education journals collectively publish more than 20,000 education research articles each year. Under current practice, no systematic way exists to move the research findings from these studies into the hands of the millions of education practitioners and policymakers in the United States who might use them.…

Personal and Professional Characteristics of Music Education Professors: Factors Associated with Expectations and Preferences of Undergraduate Students

ERIC Educational Resources Information Center

Robison, Tiger

2016-01-01

The purpose of this study was to examine music education undergraduate students' expectations of and preferences for their music education faculty members' personal and professional backgrounds and compare them to the actual backgrounds of current music teacher educators. The research questions were: Do music education undergraduate students…

Equity or Equality? Students with Language Backgrounds Other Than English. Centre for the Study of Higher Education Research Working Papers, 93.8.

ERIC Educational Resources Information Center

Isaac, Anne

This paper reviews participation patterns of migrants, refugees, and permanent residents with language backgrounds other than English (LBOTE), at Australian universities in general, and the University of Melbourne in particular. It critically examines the effectiveness of current measures designed to improve the opportunities and university…

Background and Classroom Correlates of Child Achievement, Cognitive, and Behavioural Outcomes in Rural Kenyan Schoolchildren

ERIC Educational Resources Information Center

Daley, Tamara C.; Whaley, Shannon E.; Sigman, Marian D.; Guthrie, Donald; Neumann, Charlotte G.; Bwibo, Nimrod

2005-01-01

In the current study, background data (sex, age, and SES) and classroom factors were examined as predictors of scholastic achievement and child cognitive and behavioural outcomes in a group of rural Kenyan schoolchildren during their first year of formal schooling. Previous research in this area has provided mixed results regarding the…

The Induction of Mental and Contact Contamination

ERIC Educational Resources Information Center

Lee, Michelle; Shafran, Roz; Burgess, Charlotte; Carpenter, Jodi; Millard, Emma; Thorpe, Susan

2013-01-01

Background: Extreme fear of contamination within obsessive compulsive disorder (OCD) is traditionally conceptualised as a physical phenomenon. More recent research has supported the notion of "mental" contamination (MC) in which people feel contaminated in the absence of physical contact. The current research sought to determine whether…

75 FR 32769 - Science Advisory Board Staff Office; Request for Nominations of Experts to Provide Scientific and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-09

... recognized experts with demonstrated research or operational experience assessing the environmental impacts... following disciplines: Chemistry; fate, transport and exposure assessment; toxicology; public health... biographical sketch of the nominee indicating current position, educational background, research activities...

Measuring Neutron Spectrum at MIT Research Reactor Utilizing He-3 Bonner Cylinder Approach with an Unfolding Analysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leder, A.; Anderson, A. J.; Billard, J.

2017-10-02

The Ricochet experiment seeks to measure Coherent (neutral-current) Elastic Neutrino-Nucleus Scattering using dark-matter-style detectors with sub-keV thresholds placed near a neutrino source, such as the MIT (research) Reactor (MITR), which operates at 5.5 MW generating approximately 2.2e18 neutrinos/second at the core. Currently, Ricochet is characterizing the backgrounds at MITR, the main component of which comes in the form of neutrons emitted from the core simultaneous with the neutrino signal. To characterize this background, we wrapped a Bonner cylinder around a He-3 thermal neutron detector, whose data was then unfolded to produce a neutron energy spectrum across several orders of magnitude.more » We discuss the resulting spectrum and its implications for deploying Ricochet in the future at the MITR site as well as the feasibility of reducing this background level via the addition of polyethylene shielding around the detector setup.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Heise, J.

The former Homestake gold mine in Lead, South Dakota, has been transformed into a dedicated facility to pursue underground research in rare-process physics, as well as offering research opportunities in other disciplines such as biology, geology and engineering. A key component of the Sanford Underground Research Facility (SURF) is the Davis Campus, which is in operation at the 4850-foot level (4300 m.w.e.) and currently hosts two main physics projects: the LUX dark matter experiment and the MAJORANA DEMONSTRATOR neutrinoless double-beta decay experiment. In addition, two low-background counters currently operate at the Davis Campus in support of current and future experiments. Expansionmore » of the underground laboratory space is underway at the 4850L Ross Campus in order to maintain and enhance low-background assay capabilities as well as to host a unique nuclear astrophysics accelerator facility. Plans to accommodate other future experiments at SURF are also underway and include the next generation of direct-search dark matter experiments and the Fermilab-led international long-baseline neutrino program. Planning to understand the infrastructure developments necessary to accommodate these future projects is well advanced and in some cases have already started. SURF is a dedicated research facility with significant expansion capability.« less

Current Recruitment Practices in Community Colleges and Other Post Secondary Institutions.

ERIC Educational Resources Information Center

Rinck, Lorna Lee

Research documents, conference presentations, and journal articles are used in a five-part review of recruitment strategies currently being employed at junior colleges. The first section provides background information on the development of the community college movement. The second section focuses on changing student objectives and their…

Incarcerated and Court-Involved Adolescents: Counseling an At-Risk Population.

ERIC Educational Resources Information Center

Granello, Paul F.; Hanna, Fred J.

2003-01-01

Discusses background information related to the current state of the juvenile justice system in the United States. Reviews current research regarding juvenile delinquency and outline a series of clinical techniques. Closes by providing a developmental framework for enhancing the understanding of and guiding treatment for this difficult population.…

ITS User Acceptance Research On Transportation Managers, Report 1: A Summary Of Current Iti Deployment Knowledge, Working Paper

DOT National Transportation Integrated Search

1996-03-21

THIS PAPER PROVIDES CURRENT BACKGROUND ON THE QUESTION "WHAT DO WE KNOW ABOUT WHY VARIOUS TRANSPORTATION AGENCIES DO OR DO NOT PLAN TO DEPLOY ITI", AND PROVIDES A SUMMARY OF WHAT IS KNOWN. THE FOLLOWING SECTION EXAMINES EXISTING ITI DEPLOYMENT STUDIE...

Research Review: Gene-Environment Interaction Research in Youth Depression--A Systematic Review with Recommendations for Future Research

ERIC Educational Resources Information Center

Dunn, Erin C.; Uddin, Monica; Subramanian, S. V.; Smoller, Jordan W.; Galea, Sandro; Koenen, Karestan C.

2011-01-01

Background: Depression is a major public health problem among youth, currently estimated to affect as many as 9% of US children and adolescents. The recognition that both genes (nature) and environments (nurture) are important for understanding the etiology of depression has led to a rapid growth in research exploring gene-environment interactions…

Helicopter Rotor Noise Prediction: Background, Current Status, and Future Direction

NASA Technical Reports Server (NTRS)

Brentner, Kenneth S.

1997-01-01

Helicopter noise prediction is increasingly important. The purpose of this viewgraph presentation is to: 1) Put into perspective the recent progress; 2) Outline current prediction capabilities; 3) Forecast direction of future prediction research; 4) Identify rotorcraft noise prediction needs. The presentation includes an historical perspective, a description of governing equations, and the current status of source noise prediction.

The MAJORANA DEMONSTRATOR for 0νββ: Current Status and Future Plans

NASA Astrophysics Data System (ADS)

Green, M. P.; Abgrall, N.; Aguayo, E.; Avignone, F. T.; Barabash, A. S.; Bertrand, F. E.; Boswell, M.; Brudanin, V.; Busch, M.; Byram, D.; Caldwell, A. S.; Chan, Y.-D.; Christofferson, C. D.; Combs, D. C.; Cuesta, C.; Detwiler, J. A.; Doe, P. J.; Efremenko, Yu.; Egorov, V.; Ejiri, H.; Elliott, S. R.; Fast, J. E.; Finnerty, P.; Fraenkle, F. M.; Galindo-Uribarri, A.; Giovanetti, G. K.; Goett, J.; Gruszko, J.; Guiseppe, V. E.; Gusev, K.; Hallin, A. L.; Hazama, R.; Hegai, A.; Henning, R.; Hoppe, E. W.; Howard, S.; Howe, M. A.; Keeter, K. J.; Kidd, M. F.; Kochetov, O.; Konovalov, S. I.; Kouzes, R. T.; LaFerriere, B. D.; Leon, J.; Leviner, L. E.; Loach, J. C.; MacMullin, J.; MacMullin, S.; Martin, R. D.; Meijer, S.; Mertens, S.; Nomachi, M.; Orrell, J. L.; O'Shaughnessy, C.; Overman, N. R.; Phillips, D. G.; Poon, A. W. P.; Pushkin, K.; Radford, D. C.; Rager, J.; Rielage, K.; Robertson, R. G. H.; Romero-Romero, E.; Ronquest, M. C.; Schubert, A. G.; Shanks, B.; Shima, T.; Shirchenko, M.; Snavely, K. J.; Snyder, N.; Suriano, A. M.; Thompson, J.; Timkin, V.; Tornow, W.; Trimble, J. E.; Varner, R. L.; Vasilyev, S.; Vetter, K.; Vorren, K.; White, B. R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Young, A. R.; Yu, C.-H.; Yumatov, V.

The MAJORANA DEMONSTRATOR will search for neutrinoless-double-beta decay (0νββ) in 76Ge, while establishing the feasibility of a future tonne-scale germanium-based 0νββ experiment, and performing searches for new physics beyond the Standard Model. The experiment, currently under construction at the Sanford Underground Research Facility in Lead, SD, will consist of a pair of modular high-purity germanium detector arrays housed inside of a compact copper, lead, and polyethylene shield. Through a combination of strict materials qualifications and assay, low-background design, and powerful background rejection techniques, the Demonstrator aims to achieve a background rate in the 0νββ region of interest (ROI) of no more than 3 counts in the 0νββ-decay ROI per tonne of target isotope per year (cnts/(ROI-t-y)). The current status of the Demonstrator is discussed, as are plans for its completion.

The Majorana Demonstrator for 0νββ: Current Status and Future Plans

DOE Office of Scientific and Technical Information (OSTI.GOV)

Green, Matthew P.; Avignone, F. T.; Bertrand, Jr, Fred E

2015-01-01

The Majorana Demonstrator will search for neutrinoless-double-beta decay (0νββ) in 76Ge, while establishing the feasibility of a future tonne-scale germanium-based 0νββ experiment, and performing searches for new physics beyond the Standard Model. The experiment, currently under construction at the Sanford Underground Research Facility in Lead, SD, will consist of a pair of modular high-purity germanium detector arrays housed inside of a compact copper, lead, and polyethylene shield. Through a combination of strict materials qualifications and assay, low-background design, and powerful background rejection techniques, the Demonstrator aims to achieve a background rate in the 0νββ region of interest (ROI) of nomore » more than 3cnts/(ROI-t-y). The current status of the Demonstrator is discussed, as are plans for its completion.« less

A Planetary Defense Gateway for Smart Discovery of relevant Information for Decision Support

NASA Technical Reports Server (NTRS)

Bambacus, Myra; Yang, Chaowei Phil; Leung, Ronald Y.; Barbee, Brent; Nuth, Joseph A.; Seery, Bernard; Jiang, Yongyao; Qin, Han; Li, Yun; Yu, Manzhu;

Realistic Job Previews: Can a Procedure to Reduce Turnover Also Influence the Relationship between Abilities and Performance?

ERIC Educational Resources Information Center

Wanous, John P.

1978-01-01

The current state of theory, research, and practice in realistic job previews (RJP) for recruitment is still immature. RJPs have been used to reduce employee turnover, but not necessarily to influence the job performance of newcomers. This research looks at the background, research results, and unanswered issues. (Author/RK)

A Masculine Perspective of Gendered Topics in the Research Literature on Males and Females with Intellectual Disability

ERIC Educational Resources Information Center

Wilson, Nathan J.; Parmenter, Trevor R.; Stancliffe, Roger J.; Shuttleworth, Russell P.; Parker, Desrae

2010-01-01

Background: A focus on male social pathologies may have evolved within parts of the intellectual disability research literature. This article explores this notion and makes some connections between mainstream gender theory about hegemonic masculinity and the current gendered discourse in intellectual disability research. Method: We conducted a…

"As Nature Has Formed Them": The History and Current Status of Racial Difference Research

ERIC Educational Resources Information Center

Skiba, Russell

2012-01-01

Background/Context: Research in the latter half of the 20th century purporting to show significant racial differences in intelligence and social behavior appears to pit civil rights concerns against the freedom of scientific inquiry. The core hypotheses and presumptions of recent research on racial difference are not new, however, but spring from…

Learning in Complex Environments: The Effects of Background Speech on Early Word Learning

ERIC Educational Resources Information Center

McMillan, Brianna T. M.; Saffran, Jenny R.

2016-01-01

Although most studies of language learning take place in quiet laboratory settings, everyday language learning occurs under noisy conditions. The current research investigated the effects of background speech on word learning. Both younger (22- to 24-month-olds; n = 40) and older (28- to 30-month-olds; n = 40) toddlers successfully learned novel…

Off the Streets, into Work

ERIC Educational Resources Information Center

Stanistreet, Paul

2005-01-01

The author reports on homeless people in London who have conducted the largest ever research study of the barriers to employment and employability faced by the homeless. A group of eight "peer researchers"--all with a background of homelessness, all current volunteers at Groundswell UK, an organisation which promotes self-help…

Evidence-Based Practices in Special Education: Current Assumptions and Future Considerations

ERIC Educational Resources Information Center

Russo-Campisi, Jacqueline

2017-01-01

Background: The research on evidence-based practices (EBP) in special education has shifted over the last decade from identifying efficacious interventions to exploring issues that impede implementation in the classroom. Common barriers to implementation include absence of training and resources, limited collaboration between researchers and…

A Mixed-Methods Study of Adolescents' Motivation to Read

ERIC Educational Resources Information Center

Troyer, Margaret

2017-01-01

Background: Research has shown that reading motivation is correlated with achievement. Studying motivation in older students is particularly important as reading motivation declines over the course of elementary and middle school. However, current research largely fails to reflect the nuance and complexity of reading motivation, or its variation…

School Bullying and Current Educational Practice: Re-Imagining Theories of Educational Transformation

ERIC Educational Resources Information Center

Jacobson, Ronald B.

2007-01-01

Background/Context: Bullying within schools continues despite thoughtful and well-researched anti-bullying strategies deployed against it. The bulk of research targeted toward understanding and eradicating bullying within schools is of an empirical nature. In other words, through data collection, questionnaires, interviews, ethnography,…

Human Research and Engineering Directorate, Major Laboratory Programs: Current Thrust Areas and Recent Research

DTIC Science & Technology

2010-09-01

response equipment. After the hardware and software infrastructure is complete, the focus will shift to creating soundscapes over headphones and...Background sounds will emulate a range of conditions from quiet deserts to busy urban streets. Accurate portrayals of military soundscapes and listening

Associations of Trying to Lose Weight, Weight Control Behaviors, and Current Cigarette Use among US High School Students

ERIC Educational Resources Information Center

Johnson, Jonetta L.; Eaton, Danice K.; Pederson, Linda L.; Lowry, Richard

2009-01-01

Background: Approximately one-quarter of high school students currently use cigarettes. Previous research has suggested some youth use smoking as a method for losing weight. The purpose of this study was to describe the association of current cigarette use with specific healthy and unhealthy weight control practices among 9th-12th grade students…

Extending and expanding the Darwinian synthesis: the role of complex systems dynamics.

PubMed

Weber, Bruce H

2011-03-01

Darwinism is defined here as an evolving research tradition based upon the concepts of natural selection acting upon heritable variation articulated via background assumptions about systems dynamics. Darwin's theory of evolution was developed within a context of the background assumptions of Newtonian systems dynamics. The Modern Evolutionary Synthesis, or neo-Darwinism, successfully joined Darwinian selection and Mendelian genetics by developing population genetics informed by background assumptions of Boltzmannian systems dynamics. Currently the Darwinian Research Tradition is changing as it incorporates new information and ideas from molecular biology, paleontology, developmental biology, and systems ecology. This putative expanded and extended synthesis is most perspicuously deployed using background assumptions from complex systems dynamics. Such attempts seek to not only broaden the range of phenomena encompassed by the Darwinian Research Tradition, such as neutral molecular evolution, punctuated equilibrium, as well as developmental biology, and systems ecology more generally, but to also address issues of the emergence of evolutionary novelties as well as of life itself. Copyright © 2010 Elsevier Ltd. All rights reserved.

The ELP through Time: Background Motivation, Growing Experience, Current Beliefs

ERIC Educational Resources Information Center

Argondizzo, Carmen; Sasso, Maria I.

2016-01-01

This article offers an overview of research strategies currently in use at the Language Centre of the University of Calabria and aimed at observing university students' learning habits when they are asked to use the European Language Portfolio during language courses. We present evidence of how experimental groups of students belonging to…

Elementary School Personnel's Perceptions on Childhood Obesity: Pervasiveness and Facilitating Factors

ERIC Educational Resources Information Center

Odum, Mary; McKyer, E. Lisako J.; Tisone, Christine A.; Outley, Corliss W.

2013-01-01

Background: Researchers in numerous disciplines have investigated the effects of the school environment on childhood obesity (CHO), one of the greatest current health concerns in the United States. There is a gap in current empirical evidence, however, on school personnel's perspectives of this issue. This study examined school personnel's…

Research Currents: English for Everyone.

ERIC Educational Resources Information Center

Lindfors, Judith W.

1986-01-01

Presents the "Englishes" of children from different social backgrounds that are reflected in the forms and functions of their individual ways of communicating. Discusses implications of these language varieties for the classroom. (HTH)

Responsible innovation in human germline gene editing: Background document to the recommendations of ESHG and ESHRE.

PubMed

De Wert, Guido; Heindryckx, Björn; Pennings, Guido; Clarke, Angus; Eichenlaub-Ritter, Ursula; van El, Carla G; Forzano, Francesca; Goddijn, Mariëtte; Howard, Heidi C; Radojkovic, Dragica; Rial-Sebbag, Emmanuelle; Dondorp, Wybo; Tarlatzis, Basil C; Cornel, Martina C

2018-04-01

Technological developments in gene editing raise high expectations for clinical applications, including editing of the germline. The European Society of Human Reproduction and Embryology (ESHRE) and the European Society of Human Genetics (ESHG) together developed a Background document and Recommendations to inform and stimulate ongoing societal debates. This document provides the background to the Recommendations. Germline gene editing is currently not allowed in many countries. This makes clinical applications in these countries impossible now, even if germline gene editing would become safe and effective. What were the arguments behind this legislation, and are they still convincing? If a technique could help to avoid serious genetic disorders, in a safe and effective way, would this be a reason to reconsider earlier standpoints? This Background document summarizes the scientific developments and expectations regarding germline gene editing, legal regulations at the European level, and ethics for three different settings (basic research, preclinical research and clinical applications). In ethical terms, we argue that the deontological objections (e.g., gene editing goes against nature) do not seem convincing while consequentialist objections (e.g., safety for the children thus conceived and following generations) require research, not all of which is allowed in the current legal situation in European countries. Development of this Background document and Recommendations reflects the responsibility to help society understand and debate the full range of possible implications of the new technologies, and to contribute to regulations that are adapted to the dynamics of the field while taking account of ethical considerations and societal concerns.

Exploring tool innovation: a comparison of Western and Bushman children.

PubMed

Nielsen, Mark; Tomaselli, Keyan; Mushin, Ilana; Whiten, Andrew

2014-10-01

A capacity for constructing new tools, or using old tools in new ways, to solve novel problems is a core feature of what it means to be human. Yet current evidence suggests that young children are surprisingly poor at innovating tools. However, all studies of tool innovation to date have been conducted with children from comparatively privileged Western backgrounds. This raises questions as to whether or not previously documented tool innovation failure is culturally and economically specific. In the current study, thus, we explored the innovation capacities of children from Westernized urban backgrounds and from remote communities of South African Bushmen. Consistent with past research, we found tool innovation to occur at extremely low rates and that cultural background had no bearing on this. The current study is the first to empirically test tool innovation in children from non-Western backgrounds, with our data being consistent with the view that despite its key role in human evolution, a capacity for innovation in tool making remains remarkably undeveloped during early childhood. Copyright © 2014 Elsevier Inc. All rights reserved.

A Review of the Research: Common Core State Standards for Improving Rural Children's School Readiness

ERIC Educational Resources Information Center

Bailey, Lora Battle

2014-01-01

Although a plethora of research focuses on economically at-risk preschool children in general across the United States, little can be found that investigates methods for improving rural children's academic outcomes. This review of research is intended to provide a contextual understanding of the background and current conditions that exist…

U.S. intermodal freight transportation : opportunities and obstacles

DOT National Transportation Integrated Search

1996-08-01

This study offers background information on, definition and system architecture of, and stakeholders and impediments of intermodal freight transportation. The research also provides brief information on the current and future freight movement, domest...

Radon-related Backgrounds in the LUX Dark Matter Search

NASA Astrophysics Data System (ADS)

Bradley, A.; Akerib, D. S.; Araújo, H. M.; Bai, X.; Bailey, A. J.; Balajthy, J.; Bernard, E.; Bernstein, A.; Byram, D.; Cahn, S. B.; Carmona-Benitez, M. C.; Chan, C.; Chapman, J. J.; Chiller, A. A.; Chiller, C.; Coffey, T.; Currie, A.; de Viveiros, L.; Dobi, A.; Dobson, J.; Druszkiewicz, E.; Edwards, B.; Faham, C. H.; Fiorucci, S.; Flores, C.; Gaitskell, R. J.; Gehman, V. M.; Ghag, C.; Gibson, K. R.; Gilchriese, M. G. D.; Hall, C.; Hertel, S. A.; Horn, M.; Huang, D. Q.; Ihm, M.; Jacobsen, R. G.; Kazkaz, K.; Knoche, R.; Larsen, N. A.; Lee, C.; Lindote, A.; Lopes, M. I.; Malling, D. C.; Mannino, R.; McKinsey, D. N.; Mei, D.-M.; Mock, J.; Moongweluwan, M.; Morad, J.; Murphy, A. St. J.; Nehrkorn, C.; Nelson, H.; Neves, F.; Ott, R. A.; Pangilinan, M.; Parker, P. D.; Pease, E. K.; Pech, K.; Phelps, P.; Reichhart, L.; Shutt, T.; Silva, C.; Solovov, V. N.; Sorensen, P.; O'Sullivan, K.; Sumner, T. J.; Szydagis, M.; Taylor, D.; Tennyson, B.; Tiedt, D. R.; Tripathi, M.; Uvarov, S.; Verbus, J. R.; Walsh, N.; Webb, R.; White, J. T.; Witherell, M. S.; Wolfs, F. L. H.; Woods, M.; Zhang, C.

The LUX detector is currently in operation at the Davis Campus at the 4850' level of the Sanford Underground Research Facility (SURF) in Lead, SD to directly search for WIMP dark matter. Knowing the type and rate of backgrounds is critical in a rare, low energy event search, and LUX was designed, constructed, and deployed to mitigate backgrounds, both internal and external. An important internal background are decays of radon and its daughters. These consist of alpha decays, which are easily tagged and are a tracer of certain backgrounds, and beta decays, some of which are not as readily tagged and present a background for the WIMP search. We report on studies of alpha decay and discuss implications for the WIMP search.

Does Mood Influence Text Processing and Comprehension? Evidence from an Eye-Movement Study

ERIC Educational Resources Information Center

Scrimin, Sara; Mason, Lucia

2015-01-01

Background: Previous research has indicated that mood influences cognitive processes. However, there is scarce data regarding the link between everyday emotional states and readers' text processing and comprehension. Aim: We aim to extend current research on the effects of mood induction on science text processing and comprehension, using…

Post-Traumatic Stress Disorder in Children as a Result of Violence: A Review of Current Literature.

ERIC Educational Resources Information Center

Karcher, Christopher Robb

This review of research on post-traumatic stress disorder (PTSD) in children resulting from human violence focuses on methodological issues, types of violence, treatment issues, and directions for future research. Literature reviewed is predominantly that published since 1986. An introduction offers background information and examines the…

Exploring How Institutional Structures and Practices Influence English Learners' Opportunity to Learn Social Studies

ERIC Educational Resources Information Center

Heafner, Tina L.; Plaisance, Michelle

2016-01-01

Background/Context: Current research addresses the marginalization of social studies and trends in teaching English learners (ELs) in monolingual schools; however, few studies have examined the way in which support services provided to ELs impact their exposure to social studies instruction. Purpose/Objective/Research Question/Focus of Study:…

Attendance Management in BC's K-12 Public Education System. BCTF Research Report. RR2016-01

ERIC Educational Resources Information Center

Naylor, Charlie

2016-01-01

Every British Columbia (BC) school district has been mandated and funded to initiate attendance management programs. Three "advisory" and seven "pilot" school districts have been announced. While the issue is evolving, this paper provides some background, research, and details about the current proposals for attendance…

Proposing a Knowledge Base for Teaching Academic Content to English Language Learners: Disciplinary Linguistic Knowledge

ERIC Educational Resources Information Center

Turkan, Sultan; De Oliveira, Luciana C.; Lee, Okhee; Phelps, Geoffrey

2014-01-01

Background/Context: The current research on teacher knowledge and teacher accountability falls short on information about what teacher knowledge base could guide preparation and accountability of the mainstream teachers for meeting the academic needs of ELLs. Most recently, research on specialized knowledge for teaching has offered ways to…

Two Models of Learning and Achievement: An Explanation for the Achievement Gap?

ERIC Educational Resources Information Center

Yeh, Stuart S.

2015-01-01

Background/Context: Despite decades of research, the persistence of the gap in student achievement between disadvantaged minority students and their middle-class peers remains unexplained. Purpose/Objective: The purpose of the current article is to propose a new model of the achievement gap. Research Design: Data were analyzed from three…

Language Awareness Research: Where We Are Now

ERIC Educational Resources Information Center

Svalberg, Agneta M-L.

2016-01-01

This paper outlines the context in which Language Awareness (LA) research is currently situated and where it might be going. The starting point is Eric Hawkins's vision (40 years ago) of LA as a bridge between school subjects and, in wider society, between people of different backgrounds and languages. Although considerable progress has been made…

Progress Towards a Neutral Current $$\\pi^0$$ Cross Section Analysis in the NOvA Near Detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bowles, Reed; Paley, Jonathan

The NOvA neutrino experiment is attempting to measure properties of neutrinos in order to figure out information about the universe. To detect the signal neutrino interactions, we must determine methods to identify and isolate background events. Research focused on a specific background interaction called a single prong neutral currentmore » $$\\pi^0$$ interaction. To do this, a basic cuts based analysis was performed, followed by feeding data into a multi-variate analysis package using a boosted decision tree (BDT) algorithm. Using the BDT, a a new variable was generated which separates signal and background very efficiently. Further work must still be done in order to continue improving the performance of the BDT. This research is valuable to the field of studying neutrino cross sections as it is a background which will always be present in this type of analysis.« less

Quantifying and Understanding Effects from Wildlife, Radar, and Public Engagement on Future Wind Deployment

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tegen, Suzanne

This presentation provides an overview of findings from a report published in 2016 by researchers at the National Renewable Energy Laboratory, An Initial Evaluation of Siting Considerations on Current and Future Wind Deployment. The presentation covers the background for research, the Energy Department's Wind Vision, research methods, siting considerations, the wind project deployment process, and costs associated with siting considerations.

Assessment study of infrared detector arrays for low-background astronomical research

NASA Technical Reports Server (NTRS)

Ando, K. J.

1978-01-01

The current state-of-the-art of infrared detector arrays employing charge coupled devices (CCD) or charge injection devices (CID) readout are assessed. The applicability, limitations and potentials of such arrays under the low-background astronomical observing conditions of interest for SIRFT (Shuttle Infrared Telescope Facility) are determined. The following are reviewed: (1) monolithic extrinsic arrays; (2) monolithic intrinsic arrays; (3) charge injection devices; and (4) hybrid arrays.

Low-background Gamma Spectroscopy at Sanford Underground Laboratory

NASA Astrophysics Data System (ADS)

Chiller, Christopher; Alanson, Angela; Mei, Dongming

2014-03-01

Rare-event physics experiments require the use of material with unprecedented radio-purity. Low background counting assay capabilities and detectors are critical for determining the sensitivity of the planned ultra-low background experiments. A low-background counting, LBC, facility has been built at the 4850-Level Davis Campus of the Sanford Underground Research Facility to perform screening of material and detector parts. Like many rare event physics experiments, our LBC uses lead shielding to mitigate background radiation. Corrosion of lead brick shielding in subterranean installations creates radon plate-out potential as well as human risks of ingestible or respirable lead compounds. Our LBC facilities employ an exposed lead shield requiring clean smooth surfaces. A cleaning process of low-activity silica sand blasting and borated paraffin hot coating preservation was employed to guard against corrosion due to chemical and biological exposures. The resulting lead shield maintains low background contribution integrity while fully encapsulating the lead surface. We report the performance of the current LBC and a plan to develop a large germanium well detector for PMT screening. Support provided by Sd governors research center-CUBED, NSF PHY-0758120 and Sanford Lab.

The MAJORANA DEMONSTRATOR for 0νββ: Current status and future plans

DOE PAGES

Green, M. P.; Abgrall, N.; Aguayo, E.; ...

2015-01-01

The Majorana Demonstrator will search for neutrinoless-double-beta decay (0νββ) in 76Ge, while establishing the feasibility of a future tonne-scale germanium-based 0νββ experiment, and performing searches for new physics beyond the Standard Model. The experiment, currently under construction at the Sanford Underground Research Facility in Lead, SD, will consist of a pair of modular high-purity germanium detector arrays housed inside of a compact copper, lead, and polyethylene shield. Through a combination of strict materials qualifications and assay, low-background design, and powerful background rejection techniques, the Demonstrator aims to achieve a background rate in the 0νββ region of interest (ROI) of nomore » more than 3 counts in the 0νββ-decay ROI per tonne of target isotope per year (cnts/(ROI-t-y)). The current status of the Demonstrator is discussed, as are plans for its completion.« less

Radon-related backgrounds in the LUX dark matter search

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bradley, A.; Akerib, D. S.; Araújo, H. M.

The LUX detector is currently in operation at the Davis Campus at the 4850’ level of the Sanford Underground Research Facility (SURF) in Lead, SD to directly search for WIMP dark matter. Knowing the type and rate of backgrounds is critical in a rare, low energy event search, and LUX was designed, constructed, and deployed to mitigate backgrounds, both internal and external. An important internal background are decays of radon and its daughters. These consist of alpha decays, which are easily tagged and are a tracer of certain backgrounds, and beta decays, some of which are not as readily taggedmore » and present a background for the WIMP search. We report on studies of alpha decay and discuss implications for the WIMP search.« less

Radon-related backgrounds in the LUX dark matter search

DOE PAGES

Bradley, A.; Akerib, D. S.; Araújo, H. M.; ...

2015-01-01

The LUX detector is currently in operation at the Davis Campus at the 4850’ level of the Sanford Underground Research Facility (SURF) in Lead, SD to directly search for WIMP dark matter. Knowing the type and rate of backgrounds is critical in a rare, low energy event search, and LUX was designed, constructed, and deployed to mitigate backgrounds, both internal and external. An important internal background are decays of radon and its daughters. These consist of alpha decays, which are easily tagged and are a tracer of certain backgrounds, and beta decays, some of which are not as readily taggedmore » and present a background for the WIMP search. We report on studies of alpha decay and discuss implications for the WIMP search.« less

Current Methods in Health Behavior Research Among U.S. Community College Students: A Review of the Literature

PubMed Central

Pokhrel, Pallav; Little, Melissa A.; Herzog, Thaddeus A.

2016-01-01

The majority of health behavior research involving college students in the United States has focused on 4-year college students. Two-year or community college students have been less studied, although a significant proportion of U.S. undergraduates, primarily those from disadvantaged socioeconomic and/or racial/ethnic background, are enrolled in community colleges. Thus, there is a need to enhance health behavior and health promotion research among community college students. This study systematically reviewed 42 published, peer-reviewed health behavior studies conducted among U.S. community college students in order to determine the current state of research in the area with regard to behaviors studied, research designs used, recruitment and data collection strategies practiced, rates of student participation, and characteristics of the participants represented. Findings identified the methodological limitations of current research and suggested optimal recruitment and data collection methods suitable for various research needs. Findings are discussed in the context of enhancing health behavior research among U.S. community college students. PMID:24227658

Leading-edge vortex research: Some nonplanar concepts and current challenges

NASA Technical Reports Server (NTRS)

Campbell, J. F.; Osborn, R. F.

1986-01-01

Some background information is provided for the Vortex Flow Aerodynamics Conference and that current slender wing airplanes do not use variable leading edge geometry to improve transonic drag polar is shown. Highlights of some of the initial studies combining wing camber, or flaps, with vortex flow are presented. Current vortex flap studies were reviewed to show that there is a large subsonic data base and that transonic and supersonic generic studies have begun. There is a need for validated flow field solvers to calculate vortex/shock interactions at transonic and supersonic speeds. Many important research opportunities exist for fundamental vortex flow investigations and for designing advanced fighter concepts.

The Relation between Salivary Cortisol, Callous-Unemotional Traits, and Conduct Problems in an Adolescent Non-Referred Sample

ERIC Educational Resources Information Center

Loney, Bryan R.; Butler, Melanie A.; Lima, Elizabeth N.; Counts, Carla A.; Eckel, Lisa A.

2006-01-01

Background: Previous research has suggested that adult psychopathic behavior and child callous-unemotional (CU) traits are uniquely related to low emotional reactivity. Salivary cortisol is a promising biological measure of emotional reactivity that has been relatively overlooked in research on CU traits and antisocial behavior. The current study…

Capacity of People with Intellectual Disabilities to Consent to Take Part in a Research Study

ERIC Educational Resources Information Center

Dye, Linda; Hare, Dougal Julian; Hendy, Steve

2007-01-01

Background: Within the context of current legislation relating to mental capacity in adults, the capacity of people with intellectual disabilities to consent to take part in research studies and the impact of different forms of information provision was experimentally investigated. Materials and methods: A questionnaire measure of ability to…

What Do Teachers Need? An Exploration of Evidence-Informed Practice for Classroom Assessment in Ontario

ERIC Educational Resources Information Center

Cooper, Amanda; Klinger, Don A.; McAdie, Patricia

2017-01-01

Background: Within the realm of public education, there is a well-known "knowledge to practice gap" on current conceptions of classroom assessment. A collaborative research project undertaken by the Elementary Teachers' Federation of Ontario (ETFO) and a research team at Queen's University explored the roots of this gap from the…

The Nature of Trauma Memories in Acute Stress Disorder in Children and Adolescents

ERIC Educational Resources Information Center

Salmond, C. H.; Meiser-Stedman, R.; Glucksman, E.; Thompson, P.; Dalgleish, T.; Smith, P.

2011-01-01

Background: There is increasing theoretical, clinical and research evidence for the role of trauma memory in the aetiology of acute pathological stress responses in adults. However, research into the phenomenology of trauma memories in young people is currently scarce. Methods: This study compared the nature of trauma narratives to narratives of…

Capabilities of radar as they might relate to entomological studies

NASA Technical Reports Server (NTRS)

Skolnik, M. I.

1979-01-01

A tutoral background of radar capabilities and its potential for insect research is provided. The basic principles and concepts of radar were reviewed. Information on current radar equipment was examined. Specific issues related to insect research included; target cross-section, radar frequency, tracking target recognition and false alarms, clutter reduction, radar transmitter power, and ascertained atmospheric processes.

Teaching about Christianity: A Configurative Review of Research in English Schools

ERIC Educational Resources Information Center

Fancourt, Nigel

2017-01-01

This article presents a systematic review of empirical research on teaching about Christianity in state schools in England between 1993 and 2013. First, I explain the background to this religion's current place within English religious education. The value of a configurative review is set out, and inclusion criteria are outlined, leading to the…

The Sunnel: Engaging Visitors in Solar Research via a Tunnel Through the Sun

NASA Astrophysics Data System (ADS)

DeMuth, Nora H.; Walker, C. E.

2006-12-01

The publicly accessible hallway space inside the McMath-Pierce Solar Telescope building on Kitt Peak has great untapped potential to house a display that would be relevant and understandable to KPNO visitors without the need for mediation or further explanation. An effective display would unite background content on solar physics and astronomy, and information on current solar research techniques and results in an accessible way that would excite and engage visitors. Considering these requirements, we created a concept currently dubbed the Sunnel (for “Sun-tunnel”). The Sunnel consists of two 95by 13-foot murals of the layers of the Sun stretching down the visitor hallway in the McMath-Pierce Solar Telescope. Temperatures of the layers are represented by the colors of the peak in the corresponding black-body curves, and solar features such as sunspots and pressure waves are represented by abstract designs flowing along the walls. A photon path will be laid on the floor using tiles, and several posters highlighting current solar research and background science content relevant to solar research will be displayed on one wall. An audio tour featuring interviews with solar researchers guides visitors along the Sunnel, engaging them and supporting deeper appreciation of the solar research. Installation of the murals is scheduled for early 2007, just in time to celebrate the International Heliophysical Year. DeMuth's research was supported by the NOAO/KPNO Research Experiences for Undergraduates (REU) Program which is funded by the National Science Foundation through Scientific Program Order No. 3 (AST-0243875) of the Cooperative Agreement No. AST-0132798 between the Association of Universities for Research in Astronomy (AURA) and the NSF.

[Sexually transmitted diseases: the impact of stigma and taboo on current medical care].

PubMed

Badura-Lotter, G

2014-04-01

Sexually transmitted diseases (STD) are probably the most tabooed diseases we know. The many taboos and the related stigmata shape patients' lives and significantly influence health care policies, medical research, and current problems in medical ethics. To better understand these complex influences, the still powerful taboos and related metaphors associated with illness and disease are analyzed within their cultural and historical background and concerning the actual impact on patient care and research. It becomes obvious that research and health care policies cannot be satisfyingly successful in helping people affected by STDs as long as these "nonscientific" factors are not taken into account.

Partnerships for Productivity and Advanced Skills: The Role of Colleges in Canada's Innovation System. A Background Paper

ERIC Educational Resources Information Center

Association of Canadian Community Colleges, 2010

2010-01-01

The paper provides an assessment of what we currently know about college, institute and polytechnic (collectively described here as colleges) applied research and positions them as key players in Canada's innovation system and in the federal science and technology strategy. The paper builds upon findings of previous research and reports on the…

Strategies for Digital Inclusion: Towards a Pedagogy for Embracing and Sustaining Student Diversity and Engagement with Online Learning

ERIC Educational Resources Information Center

Clarida, Baylie Hart; Bobeva, Milena; Hutchings, Maggie; Taylor, Jacqui

2016-01-01

This paper reports on the progress of a current PhD research study. The research study will evolve through four phases and eventually develop a conceptual framework for effective teaching and learning approaches that influence digital inclusion and exclusion of students from diverse backgrounds. It will also seek to identify differences in learner…

White Men's Racial Others

ERIC Educational Resources Information Center

Lensmire, Timothy J.

2014-01-01

Background/Context: Increasingly, researchers and educators have argued that alternative conceptions of Whiteness and White racial identity are needed because current conceptions have undermined, rather than strengthened, our critical pedagogies with White people. Grounded in critical Whiteness studies, and drawing especially on the writings of…

Are South African Speech-Language Therapists adequately equipped to assess English Additional Language (EAL) speakers who are from an indigenous linguistic and cultural background? A profile and exploration of the current situation

PubMed Central

Mdlalo, Thandeka; Flack, Penelope

2016-01-01

This article presents the results of a survey conducted on Speech-Language Therapists (SLTs) regarding current practices in the assessment of English Additional Language (EAL) speakers in South Africa. It forms part of the rationale for a broader (PhD) study that critiques the use of assessment instruments on EAL speakers from an indigenous linguistic and cultural background. This article discusses an aspect of the broader research and presents the background, method, findings, discussion and implications of the survey. The results of this survey highlight the challenges of human and material resources to, and the dominance of English in, the profession in South Africa. The findings contribute to understanding critical factors for acquiring reliable and valid assessment results with diverse populations, particularly the implications from a cultural and linguistic perspective. PMID:27247254

Application of Research on the Metallogenic Background in the Assessment of Mineral Resources Potentiality

NASA Astrophysics Data System (ADS)

Jia, D.; Feng, Y.; Liu, J.; Yao, X.; Zhang, Z.; Ye, T.

2017-12-01

1. Working BackgroundCurrent Status of Geological Prospecting: Detecting boundaries and bottoms, making ore search nearby; Seeing the stars, not seeing the Moon; Deep prospecting, undesirable results. The reasons of these problems are the regional metallogenic backgroud unclear and the metallogenic backgroud of the exploration regions unknown. Accordingly, Development and Research Center, CGS organized a geological setting research, in detail investigate metallogenic geological features and acquire mineralization information. 2. Technical SchemeCore research content is prediction elements of Metallogenic Structure. Adopt unified technical requirements from top to bottom, and technical route from bottom to top; Divide elements of mineral forecast and characteristics of geological structure into five elements for research and expression; Make full use of geophysical, geochemical and remote sensing inferences for the interpretation of macro information. After eight years the great project was completed. 3. Main AchievementsInnovation of basic maps compilation content of geological background, reinforce of geological structure data base of potentiality valuation. Preparation of geotectonic facies maps in different scales and professions, providing brand-new geologic background for potentiality assessment, promoting Chinese geotectonic research to the new height. Preparation of 3,375 geological structure thematic base maps of detecting working area in 6 kinds of prediction methods, providing base working maps, rock assemblage, structure of the protolith of geologic body / mineralization / ore controlling for mineral prediction of 25 ores. Enrichment and development of geotectonic facies analysis method, establishment of metallogenic background research thoughts and approach system for assessment of national mineral resources potentiality for the first time. 4. Application EffectOrientation——More and better results with less effort. Positioning——Have a definite object in view. Heart calm down——Confidence.

Application of neuro-fuzzy methods to gamma spectroscopy

NASA Astrophysics Data System (ADS)

Grelle, Austin L.

Nuclear non-proliferation activities are an essential part of national security activities both domestic and abroad. The safety of the public in densely populated environments such as urban areas or large events can be compromised if devices using special nuclear materials are present. Therefore, the prompt and accurate detection of these materials is an important topic of research, in which the identification of normal conditions is also of importance. With gamma-ray spectroscopy, these conditions are identified as the radiation background, which though being affected by a multitude of factors is ever present. Therefore, in nuclear non-proliferation activities the accurate identification of background is important. With this in mind, a method has been developed to utilize aggregate background data to predict the background of a location through the use of an Artificial Neural Network (ANN). After being trained on background data, the ANN is presented with nearby relevant gamma-ray spectroscopy data---as identified by a Fuzzy Inference System - to create a predicted background spectra to compare to a measured spectra. If a significant deviation exists between the predicted and measured data, the method alerts the user such that a more thorough investigation can take place. Research herein focused on data from an urban setting in which the number of false positives was observed to be 28 out of a total of 987, representing 2.94% error. The method therefore currently shows a high rate of false positives given the current configuration, however there are promising steps that can be taken to further minimize this error. With this in mind, the method stands as a potentially significant tool in urban nuclear nonproliferation activities.

Student Perceptions of Teacher Support

ERIC Educational Resources Information Center

Dolan, Alyson Lavigne; McCaslin, Mary

2008-01-01

Background/Context: Working theories about student goal orientation, understanding of intelligence, and affective mediation of task engagement inform current beliefs about students and learning and motivation. Much research has focused on identifying effective teaching strategies to raise the achievement of disadvantaged students; however, less is…

Teachers' perceptions on primary science teaching

NASA Astrophysics Data System (ADS)

Kijkuakul, Sirinapa

2018-01-01

This qualitative research aimed to review what primary teachers think about how to teach science in rural school contexts. Three primary schools in Thailand were purposively chosen for this study. Eleven primary science teachers of these schools were the research participants. Questionnaires, interviews, and observations were implemented to reveal the primary school teachers' educational backgrounds, science teaching context, and need for self-driven professional development. Content and discourse analysis indicated that the non-science educational background and the science teaching context implied a need for self-driven professional development. The non-science educational background teachers were generally unfamiliar with the current national science curriculum, and that they would not be comfortable when the researcher observed their science teaching practice. They also believed that experimentation was the only one strategy for teaching science, and that the priority for their teaching support was teaching media rather than their understanding of scientific concepts or teaching strategies. As implication of this research, subsequent developments on science teacher profession in rural context, therefore, need to promote teachers' understandings of nature of science and technological and pedagogical content knowledge. In addition, they should be challenged to practice on critically participatory action research for academic growth and professional learning community.

The VESUVIO Spectrometer Now and When?

NASA Astrophysics Data System (ADS)

Seel, A. G.; Krzystyniak, M.; Fernandez-Alonso, F.

2014-12-01

The current layout and mechanics of the VESUVIO spectrometer are presented in light of spectroscopic measurements using electron-volt neutrons. A brief background to the theoretical framework of deep inelastic neutron scattering is presented, with focus on data collection and instrumental design. The current capabilities and research themes for VESUVIO are discussed, and possible future instrumental developments highlighted which will enhance the instrument's ability to meet scientific inquiry and expectation.

Preliminary Validation of the Perceived Locus of Causality Scale for Academic Motivation in the Context of University Studies (PLOC-U)

ERIC Educational Resources Information Center

Sánchez de Miguel, Manuel; Lizaso, Izarne; Hermosilla, Daniel; Alcover, Carlos-Maria; Goudas, Marios; Arranz-Freijó, Enrique

2017-01-01

Background: Research has shown that self-determination theory can be useful in the study of motivation in sport and other forms of physical activity. The Perceived Locus of Causality (PLOC) scale was originally designed to study both. Aim: The current research presents and validates the new PLOC-U scale to measure academic motivation in the…

The Emerging Role of the Chief Research Informatics Officer in Academic Health Centers.

PubMed

Sanchez-Pinto, L Nelson; Mosa, Abu S M; Fultz-Hollis, Kate; Tachinardi, Umberto; Barnett, William K; Embi, Peter J

2017-08-16

The role of the Chief Research Informatics Officer (CRIO) is emerging in academic health centers to address the challenges clinical researchers face in the increasingly digitalized, data-intensive healthcare system. Most current CRIOs are the first officers in their institutions to hold that role. To date there is very little published information about this role and the individuals who serve it. To increase our understanding of the CRIO role, the leaders who serve it, and the factors associated with their success in their organizations. The Clinical Research Informatics Working Group of the American Medical Informatics Association (AMIA) conducted a national survey of CRIOs in the United States and convened an expert panel of CRIOs to discuss their experience during the 2016 AMIA Annual Symposium. CRIOs come from diverse academic backgrounds. Most have advance training and extensive experience in biomedical informatics but the majority have been CRIOs for less than three years. CRIOs identify funding, data governance, and advancing data analytics as their major challenges. CRIOs play an important role in helping shape the future of clinical research, innovation, and data analytics in healthcare in their organizations. They share many of the same challenges and see the same opportunities for the future of the field. Better understanding the background and experience of current CRIOs can help define and develop the role in other organizations and enhance their influence in the field of research informatics.

International programs related to the transmutation of transuranics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Newman, C.

1991-04-01

This report is an account of current programs outside the U.S. relating to the transmutation of transuranics. This work was performed under contract to EPRI. The investigation was based on literature surveys, personal discussions, and visits to European research establishments that are currently active in the area. Research in actinide (uranium plus transuranics) partitioning and transmutation (P-T) is actively promoted in Japan, where the largest program in research on P-T is currently underway; however, following years of relative inactivity, the concept is being revisited elsewhere. Additionally, a significant amount of research in reprocessing and advanced reactors has produced results withmore » interesting possibilities for P-T. Foreign research activities relevant to actinide burning is presented in two sections: foreign national programs, and international programs and working groups. In order to provide the reader with an ability to assess the motivators for or against development of P-T, background on political and institutional trends relating to nuclear waste management is also provided. 38 refs., 17 figs.« less

Integrated bio-fluorescence sensor.

PubMed

Thrush, Evan; Levi, Ofer; Ha, Wonill; Wang, Ke; Smith, Stephen J; Harris, James S

2003-09-26

Due to the recent explosion in optoelectronics for telecommunication applications, novel optoelectronic sensing structures can now be realized. In this work, we explore the integration of optoelectronic components towards miniature and portable fluorescence sensors. The integration of these micro-fabricated sensors with microfluidics and capillary networks may reduce the cost and complexity of current research instruments and open up a world of new applications in portable biological analysis systems. A novel optoelectronic design that capitalizes on current vertical-cavity surface-emitting laser (VCSEL) technology is explored. Specifically, VCSELs, optical emission filters and PIN photodetectors are fabricated as part of a monolithically integrated near-infrared fluorescence detection system. High-performance lasers and photodetectors have been characterized and integrated to form a complete sensor. Experimental results show that sensor sensitivity is limited by laser background. The laser background is caused by spontaneous emission emitted from the side of the VCSEL excitation source. Laser background will limit sensitivity in most integrated sensing designs due to locating excitation sources and photodetectors in such close proximity, and methods are proposed to reduce the laser background in such designs so that practical fluorescent detection limits can be achieved.

Establishing research and management priorities for invasive water primroses (Ludwigia spp.)

USDA-ARS?s Scientific Manuscript database

This technical report provides background information on invasive, aquatic Ludwigia species to assist aquatic resource managers. The report includes a description of the problems caused by these invasive plant species and why their current aggressive spread should concern resource managers and poli...

The Teacher Trainer, 2001.

ERIC Educational Resources Information Center

Woodward, Tessa, Ed.

2001-01-01

This journal is designed as a forum for trainers, teachers, and trainees all over the world. Regular features include the following: "Conference Report"; "Process Options"; "People Who Train People"; "Training around the World"; "Session Report"; "Trainee Voices"; "Current Research"; "Just for Interest"; "A Trainer Like Me"; "Trainer Background";…

Mathematics Equity. A Resource Book.

ERIC Educational Resources Information Center

Tyree, Eddy; And Others

Provided in this document is a brief summary of current research on equity in mathematics, readings on the topic, and lists of selected programs and resource materials. Readings presented include: "Teaching Mathematics in a Multicultural Setting: Some Considerations when Teachers and Students are of Differing Cultural Backgrounds"…

Neither fish nor fowl: A perceived mismatch in norms and values between oneself, other students, and people back home undermines adaptation to university.

PubMed

de Vreeze, Jort; Matschke, Christina; Cress, Ulrike

2018-03-12

Students from low social-class background often struggle to adapt to university. Previous research shows that perceived incompatibility between social-class background identity and student identity is one reason, but little is known about the underlying causes of identity incompatibility. In three studies, we expected and found that students with low subjective social-class background perceived their values differently from other students, but also differently from people back home, and both increased identity incompatibility. Identity incompatibility negatively affected the student identity. Additionally, the current research also identifies specific patterns of norm and value differences that are prone to perceived identity incompatibility. The findings demonstrate that perceived differences in values from both groups are important mechanisms for identity incompatibility induced by the transition to university that may affect student identities and potentially their university trajectories. © 2018 The British Psychological Society.

The evolution of the high-speed civil transport

NASA Technical Reports Server (NTRS)

Spearman, M. Leroy

1994-01-01

Current research directed toward the technology requirements for a high-speed civil transport (HSCT) airplane is an outgrowth of many years of activity related to air transportation. The purpose was to review some of the events that provided the background upon which current research programs are built. The review will include the subsonic era of transport aircraft and some events of the supersonic era that are related to the development of commercial supersonic transport aircraft. These events include the early NASA in-house studies and industry evaluations, the U.S. Supersonic Transport (SST) Program, the follow-on NASA supersonic cruise research programs, and the issuance of the National Aeronautical Research and Development (R&D) goals. Observations are made concerning some of the factors, both technical and nontechnical, that have had an impact on HSCT studies.

Environmental Fate and Bioaccumulation Modelling at the US Environmental Protection Agency: Application to Inform Decision-Making

EPA Science Inventory

This chapter reviews the regulatory background and policy applications driving the use of various types of environmental fate and bioaccumulation models at US EPA (air quality, surface water and watersheds, contaminated sites). Comparing current research frontiers with contempora...

Factors Correlated with the Interactional Diversity of Community College Students

ERIC Educational Resources Information Center

Jones, Willis A.

2016-01-01

This study used data from the Community College Survey of Student Engagement (CCSSE) to examine how student background characteristics, student engagement, and institutional characteristics correlate with the frequency of interactional diversity among community college students. Given the current lack of research on interactional diversity among…

The MAACK Community Initiative

ERIC Educational Resources Information Center

Reeves, Cynthia

2005-01-01

Background: Across the nation, data on school performance indicate that, as a group, African American children and youth are not faring well. Educators, researchers, and community organizations have stressed that community engagement and involvement in the education of these youth is a key element in reversing current trends. Yet, while most…

Parenting "Gifted and Talented" Children in Urban Areas: Parents' Voices

ERIC Educational Resources Information Center

Koshy, Valsa; Smith, Carole Portman; Brown, Joanna

2017-01-01

International evidence demonstrates the importance of engaging parents in the education of their "high-potential" children, yet limited research has focused on the involvement of parents from differing economic strata/backgrounds. The current study explored the dilemmas of parenting academically high-ability children from economically…

Promotive Factors and Psychosocial Adjustment among Urban Youth

ERIC Educational Resources Information Center

O'Neal, LaToya J.; Cotten, Shelia R.

2016-01-01

Background: Urban youth are often exposed to compounded risk factors which make them more vulnerable to negative outcomes. Research examining promotive factors which may reduce vulnerabilities to poor psychosocial adjustment among this population is limited. Objective: The current study addresses this limitation by examining the impact of…

Biomedical Polar Research Workshop Minutes

NASA Technical Reports Server (NTRS)

1990-01-01

This workshop was conducted to provide a background of NASA and National Science Foundation goals, an overview of previous and current biomedical research, and a discussion about areas of potential future joint activities. The objectives of the joint research were: (1) to develop an understanding of the physiological, psychological, and behavioral alterations and adaptations to extreme environments of the polar regions; (2) to ensure the health, well-being, and performance of humans in these environments; and (3) to promote the application of biomedical research to improve the quality of life in all environments.

Virtual reality: past, present and future.

PubMed

Gobbetti, E; Scateni, R

1998-01-01

This report provides a short survey of the field of virtual reality, highlighting application domains, technological requirements, and currently available solutions. The report is organized as follows: section 1 presents the background and motivation of virtual environment research and identifies typical application domain, section 2 discusses the characteristics a virtual reality system must have in order to exploit the perceptual and spatial skills of users, section 3 surveys current input/output devices for virtual reality, section 4 surveys current software approaches to support the creation of virtual reality systems, and section 5 summarizes the report.

Using Mindfulness- and Acceptance-Based Treatments With Clients From Nondominant Cultural and/or Marginalized Backgrounds: Clinical Considerations, Meta-Analysis Findings, and Introduction to the Special Series.

PubMed

Fuchs, Cara; Lee, Jonathan K; Roemer, Lizabeth; Orsillo, Susan M

2013-02-01

A growing body of research suggests that mindfulness- and acceptance-based principles can increase efforts aimed at reducing human suffering and increasing quality of life. A critical step in the development and evaluation of these new approaches to treatment is to determine the acceptability and efficacy of these treatments for clients from nondominant cultural and/or marginalized backgrounds. This special series brings together the wisdom of clinicians and researchers who are currently engaged in clinical practice and treatment research with populations who are historically underrepresented in the treatment literature. As an introduction to the series, this paper presents a theoretical background and research context for the papers in the series, highlights the elements of mindfulness- and acceptance-based treatments that may be congruent with culturally responsive treatment, and briefly outlines the general principles of cultural competence and responsive treatment. Additionally, the results of a meta-analysis of mindfulness- and acceptance-based treatments with clients from nondominant cultural and/or marginalized backgrounds are presented. Our search yielded 32 studies totaling 2,198 clients. Results suggest small (Hedges' g=.38, 95% CI=.11 - .64) to large (Hedges' g=1.32, 95% CI=.61 - 2.02) effect sizes for mindfulness- and acceptance-based treatments, which varied by study design.

Low-energy nuclear astrophysics studies at the Multicharged Ion Research Facility

NASA Astrophysics Data System (ADS)

Febbraro, Michael; Pain, Steven; Bannister, Mark; Deboer, Richard; Chipps, Kelly; Havener, Charles; Peters, Willan; Ummel, Chad; Smith, Michael; Temanson, Eli; Toomey, Rebecca; Walter, David

2017-09-01

As low-energy nuclear astrophysics progresses toward measuring reaction cross sections in the stellar burning regimes, a worldwide effort is underway to continue these measurements at underground laboratories to achieve the requisite ultra-low-background environment. These facilities are crucial for providing the required low-background environments to perform such measurements of astrophysical importance. While advances have been made in the use of accelerators underground, of equal importance is the detectors, high-current targets, and techniques required to perform such measurements. With these goals in mind, a newly established astrophysics beamline has been built at the Multicharged Ion Research Facility (MIRF) located at Oak Ridge National Laboratory. The unique capabilities of MIRF will be demonstrated through two recent low-energy above-ground measurements of the dominant s-process neutron source 13C(α,n)16O and associated beam-induced background source 13C(d,n)14N. This material is based upon work supported by the U.S. DOE, Office of Science, Office of Nuclear Physics. Research sponsored by the LDRD Program of ORNL, managed by UT-Battelle, LLC, for the U.S. DOE.

Personality Subtypes in Adolescents with Eating Disorders: Validation of a Classification Approach

ERIC Educational Resources Information Center

Thompson-Brenner, Heather; Eddy, Kamryn T.; Satir, Dana A.; Boisseau, Christina L.; Westen, Drew

2008-01-01

Background: Research has identified three personality subtypes in adults with eating disorders (EDs): a high-functioning, an undercontrolled, and an overcontrolled group. The current study investigated whether similar personality prototypes exist in adolescents with EDs, and whether these personality prototypes show relationships to external…

Chameleon Changes: An Exploration of Racial Identity Themes of Multiracial People

ERIC Educational Resources Information Center

Miville, Marie L.; Constantine, Madonna G.; Baysden, Matthew F.; So-Lloyd, Gloria

2005-01-01

The current study explored essential themes of racial identity development among 10 self-identified multiracial adults from a variety of racial backgrounds. Participants were interviewed using a semistructured protocol, and the interviews were recorded, transcribed, and then coded for themes by research team members. Four primary themes were…

Verbal Working Memory in Children with Mild Intellectual Disabilities

ERIC Educational Resources Information Center

Van der Molen, M. J.; Van Luit, J. E. H.; Jongmans, M. J.; Van der Molen, M. W.

2007-01-01

Background: Previous research into working memory of individuals with intellectual disabilities (ID) has established clear deficits. The current study examined working memory in children with mild ID (IQ 55-85) within the framework of the Baddeley model, fractionating working memory into a central executive and two slave systems, the phonological…

Paediatric Palliative Care and Intellectual Disability--A Unique Context

ERIC Educational Resources Information Center

Duc, Jacqueline K.; Herbert, Anthony Robert; Heussler, Helen S.

2017-01-01

Background: Paediatric palliative care is a nuanced area of practice with additional complexities in the context of intellectual disability. There is currently minimal research to guide clinicians working in this challenging area of care. Method: This study describes the complex care of children with life-limiting conditions and intellectual…

Cooley's Anemia: A Psychosocial Directory.

ERIC Educational Resources Information Center

National Center for Education in Maternal and Child Health, Washington, DC.

The directory is intended to aid patients and their families who are coping with the genetic disorder of Cooley's anemia. A brief review of the disease covers background, genetics, symptoms, effect on the patient, treatment, and current research. The next section looks at psychosocial needs at various times (time of diagnosis, infancy and toddler…

School Connectedness for Students in Low-Income Urban High Schools

ERIC Educational Resources Information Center

Nasir, Na'ilah Suad; Jones, Amina; McLaughlin, Milbrey Wallin

2011-01-01

Background/Context: In this article, we explore school connectedness for students in a high-poverty urban school. Current approaches to measuring connection conflate behavior and attitudinal measures of connection and rarely explore school connection in urban school settings. Purpose/Objective/Research Question/Focus of Study: We examine…

Supporting Off-Shore Students: A Preliminary Study

ERIC Educational Resources Information Center

Hussin, Virginia

2007-01-01

This paper reports on the first part of a recent research study into current initiatives to support the learning of non-English speaking background (NESB) transnational students in Asia who are studying off-shore at Australian universities. Learning support and development staff in 12 universities were surveyed using a questionnaire. The survey…

Protective Factors Based Model for Screening for Posttraumatic Distress in Adolescents

ERIC Educational Resources Information Center

Pat-Horenczyk, Ruth; Kenan, Avraham Max; Achituv, Michal; Bachar, Eytan

2014-01-01

Background: There is growing application of school-based screening to identify post-traumatic distress in students following exposure to trauma. The consensus method is based on self-report questionnaires that assess posttraumatic symptoms, functional impairment, depression or anxiety. Objective: The current research explored the possibility of…

Exergame Apps and Physical Activity: The Results of the ZOMBIE Trial

ERIC Educational Resources Information Center

Cowdery, Joan; Majeske, Paul; Frank, Rebecca; Brown, Devin

2015-01-01

Background: Although there are thousands of health and fitness smartphone apps currently available, little research exists regarding the effects of mobile app technology on physical activity behavior. Purpose: The purpose of this study was to test whether Exergame smartphone applications increase physical activity levels. Methods: This was a…

Speaking Personally--With John "Pathfinder" Lester

ERIC Educational Resources Information Center

Beaubois, Terry

2013-01-01

John Lester is currently the chief learning officer at ReactionGrid, a software company developing 3-D simulations and multiuser virtual world platforms. Lester's background includes working with Linden Lab on Second Life's education activities and neuroscience research. His primary focus is on collaborative learning and instructional…

In Their Own Words: Student Stories of Seeking Learning Support

ERIC Educational Resources Information Center

Brown, Mark; Hughes, Helen; Keppell, Mike; Hard, Natasha; Smith, Liz

2013-01-01

Many Open and Distance Learning (ODL) providers report that their students are prone to lower rates of retention and completion than campus-based students. Against this background, there is growing interest around distance-specific learning support. The current research investigated the experiences of students during their first semester as…

High Performance Computing and Networking for Science--Background Paper.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. Office of Technology Assessment.

The Office of Technology Assessment is conducting an assessment of the effects of new information technologies--including high performance computing, data networking, and mass data archiving--on research and development. This paper offers a view of the issues and their implications for current discussions about Federal supercomputer initiatives…

77 FR 25533 - Agency Requests for Approval of a New Information Collection(s): Human Subjects Experiments...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-30

... observational experiments are being conducted in support of current agency regulatory efforts that contemplate... comments [identified by Docket No. NHTSA- 2012-0046] through one of the following methods: Federal e... Information Collection. Background: NHTSA has initiated research and rulemaking to address these issues...

Children with Phonological Problems: A Survey of Clinical Practice

ERIC Educational Resources Information Center

Joffe, Victoria; Pring, T.

2008-01-01

Background: Children with phonological problems are a significant proportion of many therapists' caseloads. However, little is known about current clinical practice with these children or whether research on the effects of therapy have influenced this practice. Aims: To investigate the methods of assessment and remediation used by therapists…

The Prevalence of Developmental Instruction in Public and Catholic Schools

ERIC Educational Resources Information Center

Kelly, Sean

2010-01-01

Background/Context: Prior research has investigated differences in course-taking patterns and achievement growth in public and Catholic schools, but the nature of instruction in Catholic schools is currently understudied. One important dimension of instruction that impacts student engagement is the prevalence of developmental or student-centered…

Learning with Ubiquitous Computing

ERIC Educational Resources Information Center

Rosenheck, Louisa

2008-01-01

If ubiquitous computing becomes a reality and is widely adopted, it will inevitably have an impact on education. This article reviews the background of ubiquitous computing and current research projects done involving educational "ubicomp." Finally it explores how ubicomp may and may not change education in both formal and informal settings and…

State of the Art: Perspectives on Serving Deaf-Blind Children.

ERIC Educational Resources Information Center

Lowell, Edgar L., Ed.; Rouin, Carole C., Ed.

Provided is a collection of 23 papers on current services for deaf-blind individuals with four sections on background information, medical and diagnostic perspectives, home visitation and parent counseling, and other topics which include research, program evaluation, and legislative and legal action. Among the entries included are the following…

A versus F: The Effects of Implicit Letter Priming on Cognitive Performance

ERIC Educational Resources Information Center

Ciani, Keith D.; Sheldon, Kennon M.

2010-01-01

Background: It has been proposed that motivational responses outside people's conscious awareness can be primed to affect academic performance. The current research focused on the relationship between primed evaluative letters (A and F), explicit and implicit achievement motivation, and cognitive performance. Aim: Given the evaluative connotation…

Accountability for Results: The Realities of Data-Driven Decision Making

ERIC Educational Resources Information Center

McCaw, Donna; Watkins, Sandra

2007-01-01

The format of this book addresses the most salient questions administrators, school board members, and community stakeholders need to ask to ensure academic and fiscal accountability, providing definitions, background information and the current research. Readers will be provided with sufficient knowledge to effectively question the financial…

Convergence of Two Independent Roads Leads to Collaboration between Education and Neuroscience

ERIC Educational Resources Information Center

Koch, Kourtland R.; Timmerman, L.; Peiffer, Ann M.; Laurienti, Paul J.

2013-01-01

Collaboration is the foundation for innovative discoveries, as individuals with different backgrounds come together and combine their unique expertise. In the current article, an educational researcher and two neuroscientists relate their experiences in establishing a successful collaborative effort. The marriage of neuroscientific findings with…

Impact of Placement Type on the Development of Clinical Competency in Speech-Language Pathology Students

ERIC Educational Resources Information Center

Sheepway, Lyndal; Lincoln, Michelle; McAllister, Sue

2014-01-01

Background: Speech-language pathology students gain experience and clinical competency through clinical education placements. However, currently little empirical information exists regarding how competency develops. Existing research about the effectiveness of placement types and models in developing competency is generally descriptive and based…

The Latent Structure of Child Depression: A Taxometric Analysis

ERIC Educational Resources Information Center

Richey, J. Anthony; Schmidt, Norman B.; Lonigan, Christopher J.; Phillips, Beth M.; Catanzaro, Salvatore J.; Laurent, Jeff; Gerhardstein, Rebecca R.; Kotov, Roman

2009-01-01

Background: The current study examined the categorical versus continuous nature of child and adolescent depression among three samples of children and adolescents ranging from 5 to 19 years. Methods: Depression was measured using the Children's Depression Inventory (CDI). Indicators derived from the CDI were based on factor analytic research on…

The White Mountain Polarimeter: A telescope to measure polarization of the cosmic microwave background

NASA Astrophysics Data System (ADS)

Levy, Alan Robert

2006-07-01

The past two decades have been an exciting time in the field of cosmology and, in particular, studies of the Cosmic Microwave Background (CMB). One of the hot topics in cosmology research today is measuring and mapping CMB polarization. The White Mountain Polarimeter (WMPol) is a dedicated, ground-based microwave telescope and receiver system to measure CMB polarization which was installed in the Barcroft Observatory of the University of California White Mountain Research Station in September 2003. Presented here is a brief review of our current understanding of big bang cosmology and a description of the WMPol instrument, the observing conditions at the 3880-meter altitude Barcroft site, the data acquired during the 2004 observing campaign, and the data analysis.

Autopsy in Islam and current practice in Arab Muslim countries.

PubMed

Mohammed, Madadin; Kharoshah, Magdy A

2014-03-01

Autopsy, or post-mortem examination, is the dissection of a dead body. It is performed for many reasons. Attitudes toward dead bodies vary with religious beliefs and cultural and geographical backgrounds. We have carried out an extensive literature review to determine the Islamic view and current practice of Autopsy, in at least four Arab countries which published their experiences. Several research articles have studied the history of Islamic Autopsy as well as the current situation and legal debates about it. The overwhelming conclusion is that data is lacking. More must be published from Arabic Muslim countries and more research done to correct misconceptions. We also recommend more application of non-invasive Autopsy. Copyright © 2014 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

Utilizing Diffuse Reflection to Increase the Efficiency of Luminescent Solar Concentrators

NASA Astrophysics Data System (ADS)

Bowser, Seth; Weible, Seth; Solomon, Joel; Schrecengost, Jonathan; Wittmershaus, Bruce

A luminescent solar concentrator (LSC) consists of a high index solid plate containing a fluorescent material that converts sunlight into fluorescence. Utilizing total internal reflection, the LSC collects and concentrates the fluorescence at the plate's edges where it is converted into electricity via photovoltaic solar cells. The lower production costs of LSCs make them an attractive alternative to photovoltaic solar cells. To optimize an LSC's efficiency, a white diffusive surface (background) is positioned behind it. The background allows sunlight transmitted in the first pass to be reflected back through the LSC providing a second chance for absorption. Our research examines how the LSC's performance is affected by changing the distance between the white background and the LSC. An automated linear motion apparatus was engineered to precisely measure this distance and the LSC's electrical current, simultaneously. LSC plates, with and without the presence of fluorescent material and in an isolated environment, showed a maximum current at a distance greater than zero. Further experimentation has proved that the optimal distance results from the background's optical properties and how the reflected light enters the LSC. This material is based upon work supported by the National Science Foundation under Grant Number NSF-ECCS-1306157.

The NIMH Research Domain Criteria Initiative: Background, Issues, and Pragmatics.

PubMed

Kozak, Michael J; Cuthbert, Bruce N

2016-03-01

This article describes the National Institute of Mental Health's Research Domain Criteria (RDoC) initiative. The description includes background, rationale, goals, and the way the initiative has been developed and organized. The central RDoC concepts are summarized and the current matrix of constructs that have been vetted by workshops of extramural scientists is depicted. A number of theoretical and methodological issues that can arise in connection with the nature of RDoC constructs are highlighted: subjectivism and heterophenomenology, desynchrony and theoretical neutrality among units of analysis, theoretical reductionism, endophenotypes, biomarkers, neural circuits, construct "grain size," and analytic challenges. The importance of linking RDoC constructs to psychiatric clinical problems is discussed. Some pragmatics of incorporating RDoC concepts into applications for NIMH research funding are considered, including sampling design. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

Series: The research agenda for general practice/family medicine and primary health care in Europe. Part 2. Results: Primary care management and community orientation.

PubMed

Hummers-Pradier, Eva; Beyer, Martin; Chevallier, Patrick; Eilat-Tsanani, Sophia; Lionis, Christos; Peremans, Lieve; Petek, Davorina; Rurik, Imre; Soler, Jean Karl; Stoffers, Henri Ejh; Topsever, Pinar; Ungan, Mehmet; van Royen, Paul

2010-03-01

At the WONCA Europe conference 2009 the recently published 'Research Agenda for General Practice/Family Medicine and Primary Health Care in Europe' was presented. It is a background paper and reference manual, providing advocacy of general practice/family medicine (GP/FM) in Europe. The Research Agenda summarizes the evidence relating to the core competencies and characteristics of the WONCA Europe definition of GP/FM, and its implications for general practitioners/family doctors, researchers and policy makers. The European Journal of General Practice publishes a series of articles based on this document. In a first article, background, objectives, and methodology were discussed. In this second article, the results for the core competencies 'primary care management' and 'community orientation' are presented. Though there is a large body of research on various aspects of 'primary care management', it represents a very scattered rather than a meta view. Many studies focus on care for specific diseases, the primary/secondary care interface, or the implications of electronic patient records. Cost efficiency or process indicators of quality are current outcomes. Current literature on community orientation is mainly descriptive, and focuses on either care for specific diseases, or specific patient populations, or on the uptake of preventive services. Most papers correspond poorly to the WONCA concept. For both core competencies, there is a lack of research with a longitudinal perspective and/or relevant health or quality of life outcomes as well as research on patients' preferences and education for organizational aspects of GP/FM.

Meta-Analysis of the Effects of Early Education Interventions on Cognitive and Social Development

ERIC Educational Resources Information Center

Camilli, Gregory; Vargas, Sadako; Ryan, Sharon; Barnett, W. Steven

2010-01-01

Background/Context: There is much current interest in the impact of early childhood education programs on preschoolers and, in particular, on the magnitude of cognitive and affective gains. Purpose/Objective/Research Question/Focus of Study: Because this new segment of public education requires significant funding, accurate descriptions are…

Why Some Adults with Intellectual Disability Consult Their General Practitioner More Than Others

ERIC Educational Resources Information Center

Turk, V.; Kerry, S.; Corney, R.; Rowlands, G.; Khattran, S.

2010-01-01

Background: This research identifies factors affecting why some adults with intellectual disability (AWIDs) consult their general practitioner (GP) more than others. Little is known about these factors, despite AWIDs having higher health needs and reduced longevity. Current barriers to accessing health care need to be understood and overcome to…

Sex Differences and Brain Development: A Bibliography.

ERIC Educational Resources Information Center

Motomatsu, Nancy; Patterson, Bobbie

This bibliography cites references dealing with background material on the functions of the human brain and current research on sex differences in brain development. A list of 10 books published since 1974 is followed by a more extensive annotated bibliography of 29 articles, and a bibliography of 19 reports, complete with ERIC reference numbers…

Religious Youths' Motivations for Reading Complex, Religious Texts

ERIC Educational Resources Information Center

Rackley, Eric D.

2016-01-01

Background/Context: Research confirms that religion is a significant part of the lives of American youths, that religious texts are an essential part of their experiences in the world, and that as part of their everyday cultural practices, religious youths demonstrate strong commitments to reading religious texts. Currently, however, the field of…

Antecedents and Consequences of Situational Interest

ERIC Educational Resources Information Center

Linnenbrink-Garcia, Lisa; Patall, Erika A.; Messersmith, Emily E.

2013-01-01

Background: There is a growing body of research on situational interest (SI). Yet, we still know relatively little about how SI is supported in the classroom and the academic benefits of SI. Aim: The current study investigated (1) contextual antecedents of SI; (2) potential benefits of SI for academic outcomes; and (3) SI as a mediator of…

Data Networking for the European Academic and Research Community: Is It Important?

ERIC Educational Resources Information Center

Williams, David O.; Carpenter, Brian E.

1992-01-01

Discussion of data networking in Europe provides background on the current situation in the United States and the Pacific region. The situation in Europe is then addressed, including the present status of national networks, disciplinary networks, and the European Internet; regulatory, political, economic, and technical barriers to progress; and…

Urbanization in contemporary Arab Gulf states.

PubMed

Qutub, I Y

1983-01-01

Urbanization in the Arab Gulf states of Bahrain, Kuwait, Oman, Qatar, and the United Arab Emirates is analyzed. Topics discussed include the historical background to urbanization; current demographic trends in the region; urban characteristics and growth; socioeconomic factors influencing urbanization, with an emphasis on labor force structure; future urban strategy; and the need for urban research.

Restricted Autonomic Flexibility in Children with Social Phobia

ERIC Educational Resources Information Center

Schmitz, Julian; Kramer, Martina; Tuschen-Caffier, Brunna; Heinrichs, Nina; Blechert, Jens

2011-01-01

Background: Psychophysiological hyperresponsiveness to social-evaluative stress plays a key role in current theories of social phobia (SP). Owing to the early onset of this disorder, the study of children with SP can help to improve etiological models. However, research to date has failed to clarify whether children with SP are physiologically…

The Relationship between Reciprocity and the Emotional and Behavioural Responses of Staff

ERIC Educational Resources Information Center

Thomas, Cathryn; Rose, John

2010-01-01

Background: The current study examines a model relating to the concept of reciprocity and burnout in staff, incorporating previous research findings based upon Weiner's (1980, 1986) cognitive-emotional model linking emotions, optimism and helping behaviour, with the aim of testing the model. Materials: Staff working in community homes within the…

A Reply to the "Forbs" Article or the Political Theory of School Finance Revisited: A Victorian Essay.

ERIC Educational Resources Information Center

Hickrod, G. Alan

1987-01-01

Examines a "Forbes" cover story on educational expenditures that poses questions related to three current research guidelines for educational finance: adequacy, equity, and efficiency. Different "production functions" must be sought for children of differing family backgrounds. Without adequate education, the world's armies,…

World University Rankings: Ambiguous Signals. Go8 Backgrounder 30

ERIC Educational Resources Information Center

Group of Eight (NJ1), 2012

2012-01-01

The current main world university rankings broadly group the leading research universities of nations. Australia's Go8 universities are generally within the top 250 ranked universities, with several institutions in the top 50-100 on some measures. This recognition is commendable, however imperfect the individual rankings may be. Use is made of…

Social Networks and Parent Motivational Beliefs: Evidence from an Urban School District

ERIC Educational Resources Information Center

Curry, Katherine A.; Jean-Marie, Gaëtane; Adams, Curt M.

2016-01-01

Background: Despite devotion of substantial resources and effort to increase parent/school partnerships, gaps remain between policy rhetoric and practice, especially in high-poverty communities. Current research focuses on parent involvement or effects of parent motivational beliefs on parent choice for behavior; however, it does not address the…

The Three-Story Challenge: Implications of the "Next Generation Science Standards" for Teacher Preparation

ERIC Educational Resources Information Center

Windschitl, Mark A.; Stroupe, David

2017-01-01

The foundational document of the current science standards movement--the "Framework for K-12 Science Education"--is grounded in research about how students from diverse backgrounds learn science and the conditions under which they can participate in knowledge-building activities of the discipline. We argue that teacher educators should…

"Why You Throwing Subs?": An Exploration of Community College Students' Immediate Responses to Microaggressions

ERIC Educational Resources Information Center

Casanova, Saskias; McGuire, Keon M.; Martin, Margary

2018-01-01

Background/Context: Current research within four-year university settings reveals the daily encounters students of color and faculty have with microaggressions--brief, intentional or unintentional comments and behaviors communicating covert biases toward individuals based on their social group membership (Sue et al., 2007). The majority of all…

An Exploratory Study Of Lead Recovery In Lead-Acid Battery Lifecycle In US Market: An Evidence-Based Approach

EPA Science Inventory

Background: This research examines lead recovery and recycling in lead-acid batteries (LAB) which account for 88% of US lead consumption. We explore strategies to maximize lead recovery and recycling in the LAB lifecycle. Currently, there is limited information on recycling ra...

A Right Brain/Left Brain Model of Acting.

ERIC Educational Resources Information Center

Bowlen, Clark

Using current right brain/left brain research, this paper develops a model that explains acting's underlying quality--the actor is both himself and the character. Part 1 presents (1) the background of the right brain/left brain theory, (2) studies showing that propositional communication is a left hemisphere function while affective communication…

Mental Health Stigma Prevention: Pilot Testing a Novel, Language Arts Curriculum-Based Approach for Youth

ERIC Educational Resources Information Center

Weisman, Hannah L.; Kia-Keating, Maryam; Lippincott, Ann; Taylor, Zachary; Zheng, Jimmy

2016-01-01

Background: Researchers have emphasized the importance of integrating mental health education with academic curriculum. The focus of the current studies was "Mental Health Matters" (MHM), a mental health curriculum that is integrated with English language arts. It is taught by trained community member volunteers and aims to increase…

Lifestyle and Health Behaviours of Adults with an Intellectual Disability

ERIC Educational Resources Information Center

McGuire, B. E.; Daly, P.; Smyth, F.

2007-01-01

Background: There is currently no published research in Ireland on the health behaviours of adults with an intellectual disability (ID). With an increasing age profile and similar patterns of morbidity to the general population, the ID population would benefit from baseline data from which to establish risk factors. Methods: A questionnaire survey…

Client Goals for Participating in VHA Vocational Rehabilitation: Distribution and Relationship to Outcome

ERIC Educational Resources Information Center

Drebing, C.E.; Van Ormer, E.A.; Schutt, R.K.; Krebs, C.; Losardo, M.; Boyd, C.; Penk, W.; Rosenheck, R.

2004-01-01

Research into vocational rehabilitation (VR) consumer service preferences has been limited. The current study describes the self-reported goals of 228 applicants to a VR program sponsored by the Veterans Administration (VA) and documents the relationship of those goals to participant background variables and outcomes. Participants endorsed a wide…

A Descriptive Analysis of the Application of PETE Standards

ERIC Educational Resources Information Center

Taliaferro, Andrea R.; Ayers, Suzan F.; Housner, Lynn

2017-01-01

Background: In 2008, Ayers and Housner published a descriptive analysis of undergraduate PETE programs' application of the 2003 NASPE standards. The shift in emphases from the 2003 to 2008 standards motivated the examination of how U.S. PETE programs address current standards. Purpose: Based upon recommendations for future research, this study…

A Functional Assessment of Handmouthing among Persons with Severe and Profound Intellectual Disability

ERIC Educational Resources Information Center

Swender, Stephen L.; Matson, Johnny L.; Mayville, Stephen B.; Gonzalez, Melissa L.; McDowell, Donald

2006-01-01

Background: The behavioural function of handmouthing has been assessed across various studies utilising analogue functional analyses. The aim of the current study was to expand upon research on this relatively understudied behaviour by examining the relationship between handmouthing and "Gastro-Esophageal Reflux Disorder" (GERD), and the potential…

"You Can't Control Me!" Cultivating Authority in a Struggling Urban High School

ERIC Educational Resources Information Center

Kitzmiller, Erika M.

2013-01-01

Background/Context: Current research on urban school reform has stressed the importance of strong student-teacher relationships in creating engaging learning environments for students. This article contributes to this growing literature by showing the challenges and possibilities as teachers tried to reclaim authority and cultivate strong…

PATTERNS OF MASTERY AND CONFLICT RESOLUTION AT THE ELEMENTARY SCHOOL LEVEL.

ERIC Educational Resources Information Center

MINUCHIN, PATRICIA; AND OTHERS

EFFORTS WERE DIRECTED TOWARD THE EXPLORATION OF CONNECTIONS BETWEEN THE HOME AND SCHOOL BACKGROUND INFLUENCES OF FOURTH-GRADE CHILDREN, AND THE PATTERNS OF RESPONSE THROUGH WHICH CHILDREN MASTER CHALLENGE, REACT TO OPPORTUNITY, AND EXPRESS AND HANDLE CONFLICT. THIS CURRENT RESEARCH WAS BUILT UPON AN EARLIER STUDY WHICH ASSESSED THE EFFECTS OF…

Physical Activity and Healthy Eating in the After-School Environment

ERIC Educational Resources Information Center

Coleman, Karen J.; Geller, Karly S.; Rosenkranz, Richard R.; Dzewaltowski, David A.

2008-01-01

Background: No research to date has extensively described moderate and vigorous physical activity (MVPA) and healthful eating (HE) opportunities in the after-school environment. The current study described the quality of the after-school environment for its impact on children's MVPA and HE. Methods: An alliance of 7 elementary schools and Boys and…

Expansive Openness in Teacher Practice

ERIC Educational Resources Information Center

Kimmons, Royce

2016-01-01

Background/Context: Previous work on the use of open educational resources in K-12 classrooms has generally focused on issues related to cost. The current study takes a more expansive view of openness that also accounts for adaptation and sharing in authentic classroom contexts. Purpose/Objective/Research Question/Focus of Study The study seeks to…

"MetaTaal": Enhancing Complex Syntax in Children with Specific Language Impairment--A Metalinguistic and Multimodal Approach

ERIC Educational Resources Information Center

Zwitserlood, Rob; Wijnen, Frank; Weerdenburg, Marjolijn; Verhoeven, Ludo

2015-01-01

Background: Currently, most research on the effective treatment of morphosyntax in children with specific language impairment (SLI) pertains to younger children. In the last two decades, several studies have provided evidence that intervention for older school-age children with SLI can be effective. These metalinguistic intervention approaches…

Traffic Flow Management and Optimization

NASA Technical Reports Server (NTRS)

Rios, Joseph Lucio

2014-01-01

This talk will present an overview of Traffic Flow Management (TFM) research at NASA Ames Research Center. Dr. Rios will focus on his work developing a large-scale, parallel approach to solving traffic flow management problems in the national airspace. In support of this talk, Dr. Rios will provide some background on operational aspects of TFM as well a discussion of some of the tools needed to perform such work including a high-fidelity airspace simulator. Current, on-going research related to TFM data services in the national airspace system and general aviation will also be presented.

Virtual reality and neuropsychology: upgrading the current tools.

PubMed

Schultheis, Maria T; Himelstein, Jessica; Rizzo, Albert A

2002-10-01

Virtual reality (VR) is an evolving technology that has been applied in various aspects of medicine, including the treatment of phobia disorders, pain distraction interventions, surgical training, and medical education. These applications have served to demonstrate the various assets offered through the use of VR. To provide a background and rationale for the application of VR to neuropsychological assessment. A brief introduction to VR technology and a review of current ongoing neuropsychological research that integrates the use of this technology. VR offers numerous assets that may enhance current neuropsychological assessment protocols and address many of the limitations faced by our traditional methods.

Stressed Ge:Ga photoconductors for space-based astronomy. (Is there life beyond 120 micron)

NASA Technical Reports Server (NTRS)

Beeman, J. W.; Haller, E. E.; Hansen, W. L.; Luke, P. N.; Richards, P. L.

1989-01-01

Information is given in viewgraph form. Information is given on the characteristics of stressed Ge:Ga, a spring type stress cavity, mounting hardware, materials parameters affecting dark current, and the behavior of low dark current stressed Ge:Ga. It is concluded that detectors exist today for background-limited detection at 200 microns, that researchers are narrowing in on the significant parameters that effect dark current in stressed photoconductors, that these findings may be applied to other photoconductor materials, and that some creative problem solving for an ionizing effect reset mechanism is needed.

Developments in steady and unsteady aerodynamics for use in aeroelastic analysis and design. [for supersonic cruise aircraft

NASA Technical Reports Server (NTRS)

Yates, E. C., Jr.; Bland, S. R.

1976-01-01

A review is given of seven research projects which are aimed at improving the generality, accuracy, and computational efficiency of steady and unsteady aerodynamic theory for use in aeroelastic analysis and design. These projects indicate three major thrusts of current research efforts: (1) more realistic representation of steady and unsteady subsonic and supersonic loads on aircraft configurations of general shape with emphasis on structural-design applications, (2) unsteady aerodynamics for application in active-controls analyses, and (3) unsteady aerodynamics for the frequently critical transonic speed range. The review of each project includes theoretical background, description of capabilities, results of application, current status, and plans for further development and use.

Breast MRI radiogenomics: Current status and research implications.

PubMed

Grimm, Lars J

2016-06-01

Breast magnetic resonance imaging (MRI) radiogenomics is an emerging area of research that has the potential to directly influence clinical practice. Clinical MRI scanners today are capable of providing excellent temporal and spatial resolution, which allows extraction of numerous imaging features via human extraction approaches or complex computer vision algorithms. Meanwhile, advances in breast cancer genetics research has resulted in the identification of promising genes associated with cancer outcomes. In addition, validated genomic signatures have been developed that allow categorization of breast cancers into distinct molecular subtypes as well as predict the risk of cancer recurrence and response to therapy. Current radiogenomics research has been directed towards exploratory analysis of individual genes, understanding tumor biology, and developing imaging surrogates to genetic analysis with the long-term goal of developing a meaningful tool for clinical care. The background of breast MRI radiogenomics research, image feature extraction techniques, approaches to radiogenomics research, and promising areas of investigation are reviewed. J. Magn. Reson. Imaging 2016;43:1269-1278. © 2015 Wiley Periodicals, Inc.

Continuous Glucose Monitoring in Subjects with Type 1 Diabetes: Improvement in Accuracy by Correcting for Background Current

PubMed Central

Youssef, Joseph El; Engle, Julia M.; Massoud, Ryan G.; Ward, W. Kenneth

2010-01-01

Abstract Background A cause of suboptimal accuracy in amperometric glucose sensors is the presence of a background current (current produced in the absence of glucose) that is not accounted for. We hypothesized that a mathematical correction for the estimated background current of a commercially available sensor would lead to greater accuracy compared to a situation in which we assumed the background current to be zero. We also tested whether increasing the frequency of sensor calibration would improve sensor accuracy. Methods This report includes analysis of 20 sensor datasets from seven human subjects with type 1 diabetes. Data were divided into a training set for algorithm development and a validation set on which the algorithm was tested. A range of potential background currents was tested. Results Use of the background current correction of 4 nA led to a substantial improvement in accuracy (improvement of absolute relative difference or absolute difference of 3.5–5.5 units). An increase in calibration frequency led to a modest accuracy improvement, with an optimum at every 4 h. Conclusions Compared to no correction, a correction for the estimated background current of a commercially available glucose sensor led to greater accuracy and better detection of hypoglycemia and hyperglycemia. The accuracy-optimizing scheme presented here can be implemented in real time. PMID:20879968

Preserved figure-ground segregation and symmetry perception in visual neglect.

PubMed

Driver, J; Baylis, G C; Rafal, R D

1992-11-05

A central controversy in current research on visual attention is whether figures are segregated from their background preattentively, or whether attention is first directed to unstructured regions of the image. Here we present neurological evidence for the former view from studies of a brain-injured patient with visual neglect. His attentional impairment arises after normal segmentation of the image into figures and background has taken place. Our results indicate that information which is neglected and unavailable to higher levels of visual processing can nevertheless be processed by earlier stages in the visual system concerned with segmentation.

Current Background Noise Sources and Levels in the NASA Ames 40- by 80-Foot Wind Tunnel: A Status Report

NASA Technical Reports Server (NTRS)

Allen, Christopher S.; Jaeger, Stephen; Soderman, Paul; Koga, Dennis (Technical Monitor)

1999-01-01

Background noise measurements were made of the acoustic environment in the National Full-Scale Aerodynamics Complex 40- by 80-Foot Wind Tunnel (40x80) at NASA Ames Research Center. The measurements were acquired subsequent to the 40x80 Aeroacoustic Modernization Project, which was undertaken to improve the anechoic characteristics of the 40x80's closed test section as well as reduce the levels of background noise in the facility. The resulting 40x80 anechoic environment was described by Soderman et. al., and the current paper describes the resulting 40x80 background noise, discusses the sources of the noise, and draws comparisons to previous 40x80 background noise levels measurements. At low wind speeds or low frequencies, the 40x80 background noise is dominated by the fan drive system. To obtain the lowest fan drive noise for a given tunnel condition, it is possible in the 40x80 to reduce the fans' rotational speed and adjust the fans' blade pitch, as described by Schmidtz et. al. This idea is not new, but has now been operationally implemented with modifications for increased power at low rotational speeds. At low to mid-frequencies and at higher wind speeds, the dominant noise mechanism was thought to be caused by the surface interface of the previous test section floor acoustic lining. In order to reduce this noise mechanism, the new test section floor lining was designed to resist the pumping of flow in and out of the space between the grating slats required to support heavy equipment. In addition, the lining/flow interface over the entire test section was designed to be smoother and quieter than the previous design. At high wind speeds or high frequencies, the dominant source of background noise in the 40x80 is believed to be caused by the response of the in-flow microphone probes (required by the nature of the closed test section) to the fluctuations in the freestream flow. The resulting background noise levels are also different for probes of various diameters and types. The inflow microphone support strut is also a source of background noise but this source's impact may be minimized by careful design of the strut. In the present paper, the mechanisms mentioned above are discussed in detail. Their frequency and velocity ranges of dominance are defined and the differences between past and current facility background noise levels are presented. This paper gives valuable information for those wishing to make acoustic measurements in the 40x80. With this report and an estimate of the noise levels produced by the noise source of interest, it should be possible to determine the signal-to-noise ratios and measurement locations to successfully perform aeroacoustic testing in the NASA Ames Research Center's 40- by 80-Foot Wind Tunnel.

Ceramics in Restorative and Prosthetic DENTISTRY1

NASA Astrophysics Data System (ADS)

Kelly, J. Robert

1997-08-01

This review is intended to provide the ceramic engineer with information about the history and current use of ceramics in dentistry, contemporary research topics, and potential research agenda. Background material includes intra-oral design considerations, descriptions of ceramic dental components, and the origin, composition, and microstructure of current dental ceramics. Attention is paid to efforts involving net-shape processing, machining as a forming method, and the analysis of clinical failure. A rationale is presented for the further development of all-ceramic restorative systems. Current research topics receiving attention include microstructure/processing/property relationships, clinical failure mechanisms and in vitro testing, wear damage and wear testing, surface treatments, and microstructural modifications. The status of the field is critically reviewed with an eye toward future work. Significant improvements seem possible in the clinical use of ceramics based on engineering solutions derived from the study of clinically failed restorations, on the incorporation of higher levels of "biomimicry" in new systems, and on the synergistic developments in dental cements and adhesive dentin bonding.

School-Based Health Centers and Adolescent Substance Use: Moderating Effects of Race/Ethnicity and Socioeconomic Status

ERIC Educational Resources Information Center

Bersamin, Melina; Paschall, Mallie J.; Fisher, Deborah A.

2017-01-01

Background: School-based health centers (SBHCs) have been associated with many positive health and academic outcomes. The current study extends previous research and examines possible differences in the association between SBHC exposure and adolescent alcohol, tobacco, and other drug use by race/ethnicity, sex, and socioeconomic status (SES).…

The Situated Dynamics of Purposes of Engagement and Self-Regulation Strategies: A Mixed-Methods Case Study of Writing

ERIC Educational Resources Information Center

Kaplan, Avi; Lichtinger, Einat; Margulis, Michal

2011-01-01

Background: Common conceptions of motivation and self-regulation view them as related but distinct entities. Most research on motivation and self-regulation investigates quantitative relations between level (e.g., self-efficacy) or type of motivation (e.g., mastery goals) and level of self-regulation. Purpose: Alternatively, the current study…

Evaluation of the Applicability of HTML5 for Mobile Applications in Resource-Constrained Edge Environments

DTIC Science & Technology

2014-07-01

iOS, Blackberry , Windows Phone) and installed directly onto the device itself. CMU/SEI-2014-TN-002 | 2 2 Background 2.1 Edge Applications We...since this research started and adoption of HTML5 is growing . There are entire operating systems currently being developed in HTML5, such as Firefox

The Role of Parents in Young People's Education--A Critical Review of the Causal Evidence

ERIC Educational Resources Information Center

See, Beng Huat; Gorard, Stephen

2015-01-01

There is currently a considerable body of research suggesting that parental involvement is linked to young people's attainment at school. It is also generally agreed that a number of factors such as parental background, attention, warmth and parenting style are associated with children's later life outcomes. However, although widely assumed on the…

Relationship between Prior Legal Involvement and Current Crisis for Adults with Intellectual Disability

ERIC Educational Resources Information Center

Lunsky, Yona; Raina, Poonam; Jones, Jessica

2012-01-01

Background: Individuals with intellectual disability (ID) and legal involvement are a unique population with complex needs. To date, there has been limited research exploring the demographic and clinical profiles of individuals with ID and legal involvement that are in crisis and how they differ to individuals with ID without legal involvement.…

Daily Family Interactions among Young Adults in the United States from Latin American, Filipino, East Asian, and European Backgrounds

ERIC Educational Resources Information Center

Fuligni, Andrew; Masten, Carrie L.

2010-01-01

In contrast to the abundant research on family relationships during adolescence, the nature of family interactions during young adulthood remains comparatively unexamined. The current study explored ethnic differences in young adults' interactions with parents and siblings, the role of other activities in young adults' family interactions, and the…

Frequency of Guns in the Households of High School Seniors

ERIC Educational Resources Information Center

Coker, Ann L.; Bush, Heather M.; Follingstad, Diane R.; Brancato, Candace J.

2017-01-01

Background: In 2013, President Obama lifted the federal ban on gun violence research. The current study provides one of the first reports to estimate household gun ownership as reported by youth. Methods: In this cohort study of 3,006 high school seniors from 24 schools, we examined the frequency of household guns ownership. Results: About 65%…

Effects of a Leisure Programme on Quality of Life and Stress of Individuals with ASD

ERIC Educational Resources Information Center

Garcia-Villamisar, D. A.; Dattilo, J.

2010-01-01

Background: Even though there is research demonstrating a positive relationship between leisure participation and the two constructs of quality of life and stress reduction, current conceptualisation of leisure as a contributor to quality of life is limited. In addition, in spite of improvements in accurate diagnosis of autism spectrum disorder…

Forests and water: effects of forest management on floods, sedimentation, and water supply

Treesearch

Henry W. Anderson; Marvin D. Hoover; Kenneth G. Reinhart

1976-01-01

From the background of more than 100 years' collective experience in watershed research and from comprehensive review of the literature of forest hydrology, the authors summarize what is known about the forest's influence on the water resource, particularly the effects of current forestry practices. They first examine the fundamental hydrologic processes in...

Number of Black Children in Extreme Poverty Hits Record High. Analysis Background.

ERIC Educational Resources Information Center

Children's Defense Fund, Washington, DC.

To examine the experiences of black children and poverty, researchers conducted a computer analysis of data from the U.S. Census Bureau's Current Population Survey, the source of official government poverty statistics. The data are through 2001. Results indicated that nearly 1 million black children were living in extreme poverty, with after-tax…

One Size (Never) Fits All: Segment Differences Observed Following a School-Based Alcohol Social Marketing Program

ERIC Educational Resources Information Center

Dietrich, Timo; Rundle-Thiele, Sharyn; Leo, Cheryl; Connor, Jason

2015-01-01

Background: According to commercial marketing theory, a market orientation leads to improved performance. Drawing on the social marketing principles of segmentation and audience research, the current study seeks to identify segments to examine responses to a school-based alcohol social marketing program. Methods: A sample of 371 year 10 students…

A Preliminary Investigation of the Suitability of Aquatics for People with Severe and Profound Intellectual Disabilities

ERIC Educational Resources Information Center

Aherne, Cian; Coughlan, Barry

2017-01-01

Background: Aquatics is an under-researched but possibly appropriate form of activity for people with severe to profound intellectual disabilities (SPIDs). Aim: The current pilot study investigates the suitability of an aquatics programme for service users with SPIDs. Method: Four service users with SPID completed an 8-12-session aquatics…

Do College Students Who Identify with a Privileged Religion Experience Greater Spiritual Development? Exploring Individual and Institutional Dynamics

ERIC Educational Resources Information Center

Bowman, Nicholas A.; Small, Jenny L.

2010-01-01

College student spiritual development constitutes an important, yet understudied topic in higher education research. In particular, very little is known about whether and how this development varies among students from diverse religious backgrounds. Using a longitudinal sample of 14,527 students from 136 institutions, the current study explored…

Staff Attitudes towards Sexuality in Relation to Gender of People with Intellectual Disability: A Qualitative Study

ERIC Educational Resources Information Center

Young, Rhea; Gore, Nick; McCarthy, Michelle

2012-01-01

Background: Research has found staff attitudes regarding the sexuality of people with intellectual disability (ID) to be negative but influenced by several factors. The current study aimed to examine whether gender of people with ID affects such attitudes. Method: Semistructured interviews were completed with 10 staff members and analysed using…

A Descriptive Profile of Physical Education Teachers and Programs in Atlantic Canada

ERIC Educational Resources Information Center

Randall, Lynn; Robinson, Daniel Bruce; Fletcher, Tim

2014-01-01

The purpose of this research was to investigate the extent to which quality physical education is currently being taught in Atlantic Canada. We used survey methods to generate descriptive data indicating: (a) the backgrounds of those who teach physical education and (b) what is being taught in physical education. Our findings suggest physical…

Psychological Subtyping Finds Pathological, Impulsive, and "Normal" Groups among Adolescents Who Self-Harm

ERIC Educational Resources Information Center

Stanford, Sarah; Jones, Michael P.

2009-01-01

Background: Research to date suggests that as many as 12-15% of young people engage in self-harm behaviour; however, the current understanding of the psychological basis of adolescent self-harm is limited. The objective was to determine whether adolescents who self-harm are a psychologically homogenous group. It was hypothesised that psychological…

The Role of Traumatic Event History in Non-Medical Use of Prescription Drugs among a Nationally Representative Sample of US Adolescents

ERIC Educational Resources Information Center

McCauley, Jenna L.; Danielson, Carla Kmett; Amstadter, Ananda B.; Ruggiero, Kenneth J.; Resnick, Heidi S.; Hanson, Rochelle F.; Smith, Daniel W.; Saunders, Benjamin E.; Kilpatrick, Dean G.

2010-01-01

Background: Building on previous research with adolescents that examined demographic variables and other forms of substance abuse in relation to non-medical use of prescription drugs (NMUPD), the current study examined potentially traumatic events, depression, posttraumatic stress disorder (PTSD), other substance use, and delinquent behavior as…

Understanding Science Teachers' Implementations of Integrated STEM Curricular Units through a Phenomenological Multiple Case Study

ERIC Educational Resources Information Center

Dare, Emily A.; Ellis, Joshua A.; Roehrig, Gillian H.

2018-01-01

Background: Current reforms in K-12 STEM education call for integration between science, technology, engineering, and mathematics (STEM). Such integration of STEM disciplines at the K-12 level offers students an opportunity to experience learning in real-world, multidisciplinary contexts; however, there is little reported research about teachers'…

Informal Social Networks of People with Profound Intellectual and Multiple Disabilities: Relationship with Age, Communicative Abilities and Current Living Arrangements

ERIC Educational Resources Information Center

Kamstra, A.; van der Putten, A. A. J.; Post, W. J.; Vlaskamp, C.

2015-01-01

Background: People with profound intellectual and multiple disabilities (PIMD) have limited informal social contacts. Research to determine the factors which can positively influence establishing sound informal social contacts is required. Materials and Methods: Regression analysis for 200 people with PIMD was used to analyse how age,…

Relationship between Attachment Styles with Girls Thinking Style Functions at High School in Hamadan. September 2012

ERIC Educational Resources Information Center

Yaghobi, Abolghasem; Mohagheghy, Hosseyn; Moghadam, Nafiseh Yari; Ghodarzi, Marzieh

2012-01-01

Background: In recent years, the researchers had worked on attachment style theory in studying different aspects of individual and social life of adults and announce that attachment style is related to most behavior, thought and motivational behaviors. The aim of the current study was investigating the relationship between attachment styles with…

How Do People with Learning Disabilities Experience and Make Sense of the Ageing Process?

ERIC Educational Resources Information Center

Newberry, Gayle; Martin, Carol; Robbins, Lorna

2015-01-01

Background: Not enough is currently known about how people with learning disabilities experience and understand the ageing process. This is particularly important as the population of older people with learning disabilities is growing due to increased life expectancy. This article draws on the first author's doctoral research study, which aimed to…

Job Satisfaction, Quality of Work Life and Work Motivation in Employees with Intellectual Disability: A Systematic Review

ERIC Educational Resources Information Center

Kocman, Andreas; Weber, Germain

2018-01-01

Background: Current research on employment options for people with Intellectual Disability emphasizes the importance of employee needs and satisfaction. The study aims at systematically reviewing the literature on job satisfaction and related constructs. Methods: A systematic literature search was conducted. Studies were included if (i) they are…

Family Background, Parental Involvement, and Parent Child Interactions as Predictors of Fifth-Graders Behavior Problems

ERIC Educational Resources Information Center

Brown, Tamala P.

2012-01-01

Many studies have been conducted to address childhood behavior problems, but much remains unknown regarding the causes and factors that affect internalizing and externalizing problems in children. The purpose of the current research study was to examine the relationships between children's internalizing and externalizing behavior problems and (a)…

University Students' Involvement in Body Piercing and Adherence to Safe Piercing Practices: Do Males and Females Differ?

ERIC Educational Resources Information Center

King, Keith A.; Vidourek, Rebecca A.

2007-01-01

Background: Health concerns of body piercing include infection, scarring, allergic reactions, pain, and disease. Current gaps in the research include students' perceived piercing risks and safe piercing practices. Purpose: The purpose of this study was to examine university students' involvement in body piercing, risk consideration and adherence…

Teaching Healthy Eating to Elementary School Students: A Scoping Review of Nutrition Education Resources

ERIC Educational Resources Information Center

Peralta, Louisa R.; Dudley, Dean A.; Cotton, Wayne G.

2016-01-01

Background: School-based programs represent an ideal setting to enhance healthy eating, as most children attend school regularly and consume at least one meal and a number of snacks at school each day. However, current research reports that elementary school teachers often display low levels of nutritional knowledge, self-efficacy, and skills to…

Assessing Early Communication Skills at 12 Months: A Retrospective Study of Autism Spectrum Disorder

ERIC Educational Resources Information Center

Swain, Nathaniel Robert; Eadie, Patricia Ann; Prior, Margot Ruth; Reilly, Sheena

2015-01-01

Background: Early identification of Autism Spectrum Disorder (ASD) is currently limited by the absence of reliable biological markers for the disorder, as well as the reliability of screening and assessment tools for children aged between 6 and 18 months. Ongoing research has demonstrated the importance of early social communication skills in…

Combining the Best of Two Worlds: A Conceptual Proposal for Evidence-Informed School Improvement

ERIC Educational Resources Information Center

Brown, Chris; Schildkamp, Kim; Hubers, Mireille D.

2017-01-01

Background: Data-based decision-making (DBDM) and research-informed teaching practice (RITP) are key to teacher and school improvement. Currently, however, DBDM and RITP represent two distinct approaches to developing evidence-informed practice (EIP) and do not correspond to the all-encompassing notion of EIP envisaged by many academics and…

Low-Arousal Speech Noise Improves Performance in N-Back Task: An ERP Study

PubMed Central

Zhang, Dandan; Jin, Yi; Luo, Yuejia

2013-01-01

The relationship between noise and human performance is a crucial topic in ergonomic research. However, the brain dynamics of the emotional arousal effects of background noises are still unclear. The current study employed meaningless speech noises in the n-back working memory task to explore the changes of event-related potentials (ERPs) elicited by the noises with low arousal level vs. high arousal level. We found that the memory performance in low arousal condition were improved compared with the silent and the high arousal conditions; participants responded more quickly and had larger P2 and P3 amplitudes in low arousal condition while the performance and ERP components showed no significant difference between high arousal and silent conditions. These findings suggested that the emotional arousal dimension of background noises had a significant influence on human working memory performance, and that this effect was independent of the acoustic characteristics of noises (e.g., intensity) and the meaning of speech materials. The current findings improve our understanding of background noise effects on human performance and lay the ground for the investigation of patients with attention deficits. PMID:24204607

Theory underlying CRM training: Psychological issues in flight crew performance and crew coordination

NASA Technical Reports Server (NTRS)

Helmreich, Robert L.

1987-01-01

What psychological theory and research can reveal about training in Cockpit Resource Management (CRM) is summarized. A framework is provided for the critical analysis of current approaches to CRM training. Background factors and definitions critical to evaluating CRM are reviewed, followed by a discussion of issues directly related to CRM training effectiveness. Some of the things not known about the optimization of crew performance and the research needed to make these efforts as effective as possible are described.

Prospective communications research to support fly by light/power by wire

NASA Technical Reports Server (NTRS)

Game, David

1994-01-01

A NASA Research Grant NAG-1-1309, Distributed Fiber Optic Systems for Commercial Aircraft, was awarded during July 1991. This report primarily constitutes a summary of findings of the original background research done at that time. NASA is embarking on a research project to design the next generation of commercial aircraft, fly by light/power by wire. The objectives of this effort are to improve commercial aircraft design by (1) reducing the weight of the aircraft to improve efficiency and (2) improving the fault tolerance and safety of the aircraft by enhancing current systems with new technologies or introducing new systems into the aircraft.

Low Background Assay Results for LZ

NASA Astrophysics Data System (ADS)

Oliver-Mallory, Kelsey; Thomas, Keenan; Lux-Zeplin Collaboration; Berkeley Low Background Facility Team

2016-03-01

The next generation dark matter experiment LUX-ZEPLIN (LZ) requires careful control of intrinsic radioactivity in all critical detector components in order to reach its unprecedented target sensitivity to Weakly Interacting Massive Particles (WIMPs): 2 ×10-48 cm2 at 50 GeV/c2. Appropriate material selection is essential to meeting this goal, and an extensive campaign of low background screening is currently being carried out using assay devices at the Sanford Underground Research Facility and the Boulby Underground Laboratory. We will present results from this work, including measurements for the Ti cryostat, PMT bases, PMT raw materials, PTFE, and other components. This work was partially supported by the U.S. Department of Energy (DOE) under Award Number DE-AC02-05CH11231, and is based upon work supported by the National Science Foundation Graduate Research Fellowship under Grant No. 1106400.

The relation between finger gnosis and mathematical ability: why redeployment of neural circuits best explains the finding

PubMed Central

Penner-Wilger, Marcie; Anderson, Michael L.

2013-01-01

This paper elaborates a novel hypothesis regarding the observed predictive relation between finger gnosis and mathematical ability. In brief, we suggest that these two cognitive phenomena have overlapping neural substrates, as the result of the re-use (“redeployment”) of part of the finger gnosis circuit for the purpose of representing numbers. We offer some background on the relation and current explanations for it; an outline of our alternate hypothesis; some evidence supporting redeployment over current views; and a plan for further research. PMID:24367341

The relation between finger gnosis and mathematical ability: why redeployment of neural circuits best explains the finding.

PubMed

Penner-Wilger, Marcie; Anderson, Michael L

2013-01-01

This paper elaborates a novel hypothesis regarding the observed predictive relation between finger gnosis and mathematical ability. In brief, we suggest that these two cognitive phenomena have overlapping neural substrates, as the result of the re-use ("redeployment") of part of the finger gnosis circuit for the purpose of representing numbers. We offer some background on the relation and current explanations for it; an outline of our alternate hypothesis; some evidence supporting redeployment over current views; and a plan for further research.

The trigger card system for the MAJORANA DEMONSTRATOR

NASA Astrophysics Data System (ADS)

Thompson, William; Anderson, John; Howe, Mark; Meijer, Sam; Wilkerson, John; Majorana Collaboration

2014-09-01

The aim of the MAJORANA DEMONSTRATOR is to demonstrate the feasibility of providing low enough background levels to search for neutrinoless double-beta decay (0 νββ) in an array of germanium detectors enriched to 87% in 76Ge. Currently, it is unknown if this decay process occurs; however, observation of such a decay process would show that lepton number is violated, confirm that neutrinos are Majorana particles, and yield information on the absolute mass scale of the neutrino. With current experimental results indicating a half-life greater than 2 x 1025 years for this decay, the minimization of background events is of critical importance. Utilizing time correlation, coincidence testing is able to reject multi-detector events that may otherwise be mistaken for 0 νββ when viewed independently. Here, we present both the hardware and software of the trigger card system, which provides a common clock to all digitizers and the muon veto system, thereby enabling the rejection of background events through coincidence testing. Current experimental results demonstrate the accuracy of the distributed clock to be within two clock pulses (20 ns) across all system components. A test system is used to validate the data acquisition system. The aim of the MAJORANA DEMONSTRATOR is to demonstrate the feasibility of providing low enough background levels to search for neutrinoless double-beta decay (0 νββ) in an array of germanium detectors enriched to 87% in 76Ge. Currently, it is unknown if this decay process occurs; however, observation of such a decay process would show that lepton number is violated, confirm that neutrinos are Majorana particles, and yield information on the absolute mass scale of the neutrino. With current experimental results indicating a half-life greater than 2 x 1025 years for this decay, the minimization of background events is of critical importance. Utilizing time correlation, coincidence testing is able to reject multi-detector events that may otherwise be mistaken for 0 νββ when viewed independently. Here, we present both the hardware and software of the trigger card system, which provides a common clock to all digitizers and the muon veto system, thereby enabling the rejection of background events through coincidence testing. Current experimental results demonstrate the accuracy of the distributed clock to be within two clock pulses (20 ns) across all system components. A test system is used to validate the data acquisition system. We acknowledge support from the Office of Nuclear Physics in the DOE Office of Science, the Particle Astrophysics and REU Programs of the NSF, and the Sanford Underground Research Laboratory.

Varying ethics rules in clinical research and routine patient care – research ethics committee chairpersons’ views in Finland

PubMed Central

2014-01-01

Background To present empirical data on how the variation in regulating clinical research and patient care was perceived in Finland between 2009 and 2012. Methods Notes of interviews with 22 research ethics committee (REC) chairpersons were analyzed to identify whether differences in the regulation of clinical research and patient care were addressed. REC chairpersons’ opinions on three imaginary cases of clinical research projects challenging current research ethics rules (vignettes) were requested with a questionnaire; 18 of the 22 interviewed chairpersons responded. Results Based on REC chairpersons’ interviews, the differences between care and research regulation were not considered important issues in Finland. In the vignettes, REC chairpersons’ assumptions on how their REC would decide varied in regard to allowing research without informed consent, while solutions that are not allowed by current law were even anticipated. Mostly, but not always, the chairpersons’ own personal view agreed with their REC. Conclusions The distinction between care and research regulation has not been publicly challenged by Finnish RECs, even though it is a challenge when research relevant to health care is carried out. There is a need for debate and changes in laws and practices. PMID:24666735

Schools as Architecture for Newcomers and Strangers: The Perfect School as Public School?

ERIC Educational Resources Information Center

Masschelein, Jan; Simons, Maarten

2010-01-01

Background/Context: The article reflects on the public role of education on the occasion of the 50th anniversary of the publication of Hannah Arendt's essay, "The Crisis in Education" and in facing the current transformation of public policy into "new public management." Purpose/Objective/Research Question/Focus of Study: Based on Arendt's essay,…

Non-Attendance and Utilization of a Speech and Language Therapy Service: A Retrospective Pilot Study of School-Aged Referrals

ERIC Educational Resources Information Center

Curran, Amy; Flynn, Catherine; Antonijevic-Elliott, Stanislava; Lyons, Rena

2015-01-01

Background: Non-attendance and inappropriate referrals affect the effective and efficient running of healthcare services. Non-engagement with speech and language therapy (SLT) services may lead to negative long-term consequences for children in need of SLT intervention. Currently there is a dearth of research on non-attendance and non-engagement…

Taiwanese Parents' Beliefs Regarding Young Children's Art Education and the Actual Art Achievements of Children

ERIC Educational Resources Information Center

Hsiao, Ching-Yuan; Pai, Tzu-Chi

2014-01-01

The research goal is to ascertain the current beliefs of the parents of preschool children regarding art education in Taiwan. Background factors on the parents were tested to show the differences between the parents' beliefs regarding art education and the actual art achievements of the children. From there, relationships between the beliefs and…

Catechol-O-Methyltransferase "Val[superscript 158]Met" Genotype, Parenting Practices and Adolescent Alcohol Use: Testing the Differential Susceptibility Hypothesis

ERIC Educational Resources Information Center

Laucht, Manfred; Blomeyer, Dorothea; Buchmann, Arlette F.; Treutlein, Jens; Schmidt, Martin H.; Esser, Gunter; Jennen-Steinmetz, Christine; Rietschel, Marcella; Zimmermann, Ulrich S.; Banaschewski, Tobias

2012-01-01

Background: Recently, first evidence has been reported for a gene-parenting interaction (G x E) with regard to adolescent alcohol use. The present investigation set out to extend this research using the catechol-O-methyltransferase ("COMT") "Val[superscript 158]Met" polymorphism as a genetic susceptibility factor. Moreover, the current study…

Physical Education Pedagogy: An Analysis of Research Published in Spanish Journals (2005-2014)

ERIC Educational Resources Information Center

Molina, Pere; Martínez-Baena, Alejandro; Villamón, Miguel

2017-01-01

Background: The majority of reviews related to Physical Education Pedagogy (PEP) refer to the English-speaking world. Some of these assert the need to obtain more data and provide reviews of what has been investigated in languages other than English to be able to assess the current state of the field internationally. Purpose: The aim of this study…

Paid Support Workers for Adults with Intellectual Disabilities; Their Current Knowledge of Hearing Loss and Future Training Needs

ERIC Educational Resources Information Center

McShea, Lynzee; Fulton, John; Hayes, Catherine

2016-01-01

Background: People with intellectual disabilities are more likely to have hearing loss than the general population. For those unable to self-advocate, the responsibility of detection and management falls to their caregivers. Methods: This is the first cycle of a project using action research methodology to improve services. Twenty care workers…

Sibling Voices: The Self-Reported Mental Health of Siblings of Children with a Disability

ERIC Educational Resources Information Center

Giallo, Rebecca; Gavidia-Payne, Susana; Minett, Belinda; Kapoor, Aparna

2012-01-01

Background: There is increasing interest in the experiences and well-being of siblings growing up with a brother or sister with a disability in Australia. However, research to date has primarily obtained parent reports of sibling adjustment and mental health. Therefore, the aim of the current study was threefold: (1) to report on the mental health…

Scientific-Theoretical Background the Organization of Geobotany Employees of the Micro Enterprises Sport and Recreation Sector

ERIC Educational Resources Information Center

Andruhina, Tatyana V.; Dorozhkin, Evgenij M.; Zaitseva, Ekaterina V.; Komleva, Svetlana V.; Sosnin, Alexander S.; Savinova, Valentina A.

2016-01-01

The relevance of the research problem due to the needs of the labor market, terms of developing economy of micro-entrepreneurship in sport and recreation sector and the demands of the subject of labour activity to professional training without discontinuing work. The purpose of the article is to understand the current issues aspects of pedagogical…

Predicting Reading Comprehension Academic Achievement in Late Adolescents with Velo-Cardio-Facial (22q11.2 Deletion) Syndrome (VCFS): A Longitudinal Study

ERIC Educational Resources Information Center

Antshel, K.; Hier, B.; Fremont, W.; Faraone, S. V.; Kates, W.

2014-01-01

Background: The primary objective of the current study was to examine the childhood predictors of adolescent reading comprehension in velo-cardio-facial syndrome (VCFS). Although much research has focused on mathematics skills among individuals with VCFS, no studies have examined predictors of reading comprehension. Methods: 69 late adolescents…

Patterns of Victimization Locations in Elementary School Children: Effects of Grade Level and Gender

ERIC Educational Resources Information Center

Fite, Paula J.; Williford, Anne; Cooley, John L.; DePaolis, Kathryn; Rubens, Sonia L.; Vernberg, Eric M.

2013-01-01

Background: Little research has examined the locations in which youth are victimized, particularly outside the school context. Further, it is not clear if the locations in which youth are victimized vary as a function of grade level or gender. Objective: The goals of the current study were to: (1) Determine the locations inside and outside of the…

1:1 Laptop Implications and District Policy Considerations

ERIC Educational Resources Information Center

Sauers, Nicholas J.

2012-01-01

Background. The state of Iowa has seen a drastic increase in the number of schools that provide one laptop for each student. These 1:1 schools have invested large amounts of time and money into becoming a 1:1 school. The current research on 1:1 schools is sparse, and policy makers are actively trying to evaluate those programs. Purpose. To…

District Decision-Makers' Considerations of Equity and Equality Related to Students' Opportunities to Learn Algebra

ERIC Educational Resources Information Center

Herbel-Eisenmann, Beth A.; Keazer, Lindsay; Traynor, Anne

2018-01-01

Background/Context: In this article we explore equity issues related to school district decision-making about students' opportunities to learn algebra. We chose algebra because of the important role it plays in the U.S. as a gatekeeper to future academic success. Current research has not yet explored issues of equity in district-level…

For Researchers on Obesity: Historical Review of Extra Body Weight Definitions.

PubMed

Komaroff, Marina

2016-01-01

Rationale. The concept of obesity has been known since ancient world; however, the current standard definition of obesity was endorsed only about a decade ago. There is a need for researches to understand multiple approaches to defining obesity and how and why the standard definition was developed. The review will help to grasp the complexity of the problem and can lead to novel hypotheses in obesity research. Objective. This paper focuses on the objective to understand historical background on the development of "reference and standard tables" of weight as a platform for normal versus abnormal body weight definition. Methods. A systematic literature review was performed to chronologically summarize the definition of body weight from time of Hippocrates till the year of 2010. Conclusion. This paper presents the historical background on the development of "reference and standard tables" of weight as a platform for normal versus abnormal body weight definition. Knowledge of historical approaches to the concept of obesity can motivate researchers to find new hypotheses and utilize the appropriate obesity assessments to address their objectives.

Commentary: justice and medical research: a global perspective.

PubMed

Benatar, S R

2001-08-01

Economic globalization has profound implications for health. The scale of injustice at a global level, reflected in inexorably widening disparities in wealth and health, also has critical implications for health related research--in particular when the opportunities for exploiting research subjects are carefully considered. The challenge of developing universal guidelines for international clinical research is addressed against the background of a polarizing, yet interdependent, world in which all are ultimately threatened by lack of social justice. It is proposed that in such a world there is a need for new ways of thinking about research and its relevance to health at a global level. Responsibility to use knowledge and power wisely requires more radical changes to guidelines for research ethics than are currently under consideration.

Can a good tree bring forth evil fruit? The funding of medical research by industry

PubMed Central

Capps, Benjamin

2016-01-01

Background Systematic reviews analysing the influence of funding on the conduct of research have shown how Conflicts of Interest (COIs) create bias in the production and dissemination of data. Sources of data The following is a critical analysis of current opinions in respect to COIs created by industry funding of medical research in academic institutions. Areas of agreement Effective mechanisms are necessary to manage COIs in medical research, and to prohibit COIs that clearly affect validity of research conduct and outcomes. Areas of controversy While most hold that industry investment in university research is not a barrier to good science, there are questions about how securing funding opportunities might be prioritized over the risks of potential COIs. It is argued that COIs are inherent risks to research integrity, requiring the strengthening of current governance frameworks. Growing points The focus on COIs, created by the ostensibly categorical actions of industry, challenges the evolving research priorities within academic institutions. Areas timely for developing research Less well-defined COIs are equally culpable to financial ones, in terms of the systemic damage they do to science. So, are they appropriately managed as risks within university research settings? PMID:27151955

Disseminating research findings: what should researchers do? A systematic scoping review of conceptual frameworks

PubMed Central

2010-01-01

Background Addressing deficiencies in the dissemination and transfer of research-based knowledge into routine clinical practice is high on the policy agenda both in the UK and internationally. However, there is lack of clarity between funding agencies as to what represents dissemination. Moreover, the expectations and guidance provided to researchers vary from one agency to another. Against this background, we performed a systematic scoping to identify and describe any conceptual/organising frameworks that could be used by researchers to guide their dissemination activity. Methods We searched twelve electronic databases (including MEDLINE, EMBASE, CINAHL, and PsycINFO), the reference lists of included studies and of individual funding agency websites to identify potential studies for inclusion. To be included, papers had to present an explicit framework or plan either designed for use by researchers or that could be used to guide dissemination activity. Papers which mentioned dissemination (but did not provide any detail) in the context of a wider knowledge translation framework, were excluded. References were screened independently by at least two reviewers; disagreements were resolved by discussion. For each included paper, the source, the date of publication, a description of the main elements of the framework, and whether there was any implicit/explicit reference to theory were extracted. A narrative synthesis was undertaken. Results Thirty-three frameworks met our inclusion criteria, 20 of which were designed to be used by researchers to guide their dissemination activities. Twenty-eight included frameworks were underpinned at least in part by one or more of three different theoretical approaches, namely persuasive communication, diffusion of innovations theory, and social marketing. Conclusions There are currently a number of theoretically-informed frameworks available to researchers that can be used to help guide their dissemination planning and activity. Given the current emphasis on enhancing the uptake of knowledge about the effects of interventions into routine practice, funders could consider encouraging researchers to adopt a theoretically-informed approach to their research dissemination. PMID:21092164

A Study of the Air Force’s Current Method of Training Individuals to Use Contractor Developed Software in Information Management and the Perceived Effectiveness of Training

DTIC Science & Technology

1990-12-01

and only one Navy study was located. Lt. Cynthia S. Lassnoff (USN) conducted a case analysis of the training requirements of Navy microcomputer users...effectiveness of the training. The study found that greater emphasis must be placed on developing and supporting the use of a standardized training...recommends areas of further research based on the findings of this research. 1-8 II. Background No previous studies were located that evaluated how the Air

Progress towards barium daughter tagging in Xe136 decay using single molecule fluorescence imaging

NASA Astrophysics Data System (ADS)

McDonald, Austin; NEXT Collaboration

2017-09-01

The existence of Majorana fermions is of great interest as it may be related to the asymmetry between matter and anti-matter particles in the universe. However, the search for them has proven to be a difficult one. Neutrino-less Double Beta decay (NLDB) offers a possible opportunity for direct observation of a Majorana Fermion. The rate for NLDB decay may be as low as 1 count /ton /year if the mass ordering is inverted. Current detector technologies have background rates between 4 to 300 count /ton /year /ROI at the 100kg scale which is much larger than the universal goal of 0.1 count /ton /year /ROI desired for ton-scale detectors. The premise of my research is to develop new detector technologies that will allow for a background-free experiment. My current work is to develop a sensor that will tag the daughter ion Ba++ from the Xe136 decay. The development of a sensor that is sensitive to single barium ion detection based on the single molecule fluorescence imaging technique is the major focus of this work. If successful, this could provide a path to a background-free experiment.

Progress towards barium daughter tagging in Xe136 decay using single molecule fluorescence imaging

NASA Astrophysics Data System (ADS)

McDonald, Austin; Jones, Ben; Benson, Jordan; Nygren, David; NEXT Collaboration

2017-01-01

The existence of Majorana Fermions has been predicted, and is of great interest as it may be related to the asymmetry between matter and anti-matter particles in the universe. However, the search for them has proven to be a difficult one. Neutrino-less Double Beta decay (NLDB) offers a possible opportunity for direct observation of a Majorana Fermion. The rate for NLDB decay may be as low as 1 count / ton / year . Current detector technologies have background rates between 4 to 300 count / ton / year / ROI which is much larger than the universal goal of 0 . 1 count / ton / year / ROI desired for ton-scale detectors. The premise of my research is to develop new detector technologies that will allow for a background-free experiment. My current work is to develop a sensor that will tag the daughter ion Ba++ from the Xe136 decay. The development of a sensor that is sensitive to single barium ion detection based on the single molecule fluorescence imaging technique is the major focus of this work. If successful, this could provide a path to a background-free experiment.

Ethical issues in perinatal mental health research.

PubMed

Brandon, Anna R; Shivakumar, Geetha; Lee, Simon Craddock; Inrig, Stephen J; Sadler, John Z

2009-11-01

To review the background of current ethical standards for the conduct of perinatal mental health research and describe the ethical challenges in this research domain. Current literature reflects a growing sentiment in the scientific community that having no information regarding the impact of psychiatric treatment on the mother and developing fetus/infant poses dangers that may exceed the risks involved in research. However, without sufficient consensus across the scientific community, both regulatory bodies and perinatal researchers find themselves without a framework for decision making that satisfactorily limits the risks and facilitates the benefits of participation of pregnant and lactating women in clinical research. Psychiatric research in perinatal mental health is critically important as it enables clinicians and patients to participate in informed decision-making concerning treatment for psychiatric disorders. Specific areas of concern include fetal safety, maternal risk, the therapeutic misconception, commercial interests, forensic/legal issues, the informed consent process, and study design. Developing guidelines that address ethical challenges and include the views and concerns of multiple stakeholders could improve the access of perinatal women to the benefits of participation in mental health research in addition to providing evidence-based mental healthcare for this subpopulation.

Health inequalities among workers with a foreign background in Sweden: do working conditions matter?

PubMed

Dunlavy, Andrea C; Rostila, Mikael

2013-07-10

Employment and working conditions are key social determinants of health, yet current information is lacking regarding relationships between foreign background status, working conditions and health among workers in Sweden. This study utilized cross-sectional data from the 2010 Swedish Level of Living Survey (LNU) and the Level of Living Survey for Foreign Born Persons and their Children (LNU-UFB) to assess whether or not health inequalities exist between native Swedish and foreign background workers and if exposure to adverse psychosocial and physical working conditions contributes to the risk for poor health among foreign background workers. A sub-sample of 4,021 employed individuals aged 18-65 was analyzed using logistic regression. Eastern European, Latin American and Other Non-Western workers had an increased risk of both poor self-rated health and mental distress compared to native Swedish workers. Exposure to adverse working conditions only minimally influenced the risk of poor health. Further research should examine workers who are less integrated or who have less secure labor market attachments and also investigate how additional working conditions may influence associations between health and foreign background status.

The Relevance of the Functional 5-HT1A Receptor Polymorphism for Attention and Working Memory Processes during Mental Rotation of Characters

ERIC Educational Resources Information Center

Beste, Christian; Heil, Martin; Domschke, Katharina; Konrad, Carsten

2010-01-01

Numerous lines of research indicate that attentional processes, working memory and saccadic processes are highly interrelated. In the current study, we examine the relation between these processes with respect to their cognitive-neurophysiological and neurobiological background by means of event-related potentials (ERPs) in a sample of N = 72…

Is There a Typology of Teacher and Leader Responders to Call and Do They Cluster in Different Types of Schools? A Two-Level Latent Class Analysis of Call Survey Data

ERIC Educational Resources Information Center

Bowers, Alex J.; Blitz, Mark; Modeste, Marsha; Salisbury, Jason; Halverson, Richard R.

2017-01-01

Background: Across the recent research on school leadership, leadership for learning has emerged as a strong framework for integrating current theories, such as instructional, transformational, and distributed leadership as well as effective human resource practices, instructional evaluation, and resource allocation. Yet, questions remain as to…

Structured Task versus Free Play: The Influence of Social Context on Parenting Quality, Toddlers' Engagement with Parents and Play Behaviors, and Parent-Toddler Language Use

ERIC Educational Resources Information Center

Kwon, Kyong-Ah; Bingham, Gary; Lewsader, Joellen; Jeon, Hyun-Joo; Elicker, James

2013-01-01

Background: Little empirical research examines relations among the quality of both mothers' and fathers' social emotional and linguistic support of toddlers across multiple parent-child interaction contexts. Objective: The current study investigated the influence of parent gender (mother vs. father) and activity setting (structured task vs. free…

The Influence of Cultural Background on Parental Perceptions of Adolescent Gambling Behaviour: A Canadian Study

ERIC Educational Resources Information Center

Campbell, Colin A.; Derevensky, Jeffrey L.; Meerkamper, Eric; Cutajar, Jo

2012-01-01

Considerable research has begun to address youth gambling issues from a bio-psycho-social perspective. The current Canadian national study adds to this body of knowledge by examining the cultural influences impacting parent's attitudes, behaviors and perceptions of youth gambling. A total of 3,279 parents with a child between the ages of 13 and 18…

The Health Effects of Attending College for Latina Undergraduate Students and Their Families

ERIC Educational Resources Information Center

Mount, Jill Katherine

2010-01-01

Background and objective. Latinos are the largest ethnic minority in the U.S. and by 2050 they are estimated to become one quarter of the population, yet only one in ten has a college degree. More Latino women (Latinas) are currently attending college than Latino men. To date research has focused on their experiences and where they obtain support…

Digital Video Interactive (DVI) Based Authoring Tools for Unit Level Training. Final Technical Report for Period 27 September 1991 - 27 May 1992.

ERIC Educational Resources Information Center

Hyltin, John P.; And Others

This report describes DVI (Digital Video Interactive) technology, current authoring languages and tools, and the reasons for developing new tools and applications. The work described was performed by Betac Corporation as part of a Phase II Small Business Innovation Research project. Section I provides background information on DVI. DVI technology…

Mike's Educational Program: Long Island, New York. Case Study. Social Relationships of Children and Adolescents with Deaf-Blindness Research Project.

ERIC Educational Resources Information Center

Mar, Harvey H.; Sall, Nancy

This case study describes the educational history and current program of Mike, a mainstreamed sixth-grader with deaf-blindness. It addresses the boy's successes and the ongoing challenges faced by his family, his educational team, and his peers. Background information notes his diagnosis of total blindness and moderate to severe hearing loss, his…

"The Kings New Training Courses"--A Research Project: The New Clothes May Have a CBT Label, but Do They Really Promote Lifelong Learning?

ERIC Educational Resources Information Center

Barratt-Pugh, Llandis

This paper outlines the background and preliminary findings of a study currently in progress in Perth, Western Australia, to investigate the relationship between competence based training and the development of lifelong learning skills. The paper explores both the underlying aims of competency-based training (CBT) and the educational antecedents…

Barriers and Facilitators to the Use of High-Technology Augmentative and Alternative Communication Devices: A Systematic Review and Qualitative Synthesis

ERIC Educational Resources Information Center

Baxter, Susan; Enderby, Pam; Evans, Philippa; Judge, Simon

2012-01-01

Background: There has been a rapid growth in recent years of available technologies for individuals with communication difficulties. Research in the area is currently underdeveloped with practitioners having a limited body of work on which to draw to guide the process of intervention. Concerns have been raised that this newly developed technology…

Voices of Young People with a History of Specific Language Impairment (SLI) in the First Year of Post-16 Education

ERIC Educational Resources Information Center

Palikara, Olympia; Lindsay, Geoff; Dockrell, Julie E.

2009-01-01

Background: Giving young people more and better opportunities to have their voices heard is a key feature of current educational policy and research internationally and in the UK. Aims: To examine the views of young people with a history of specific language impairment (SLI) as they entered post-16 education. Methods & Procedures: A total of…

Current-limited electron beam injection

NASA Technical Reports Server (NTRS)

Stenzel, R. L.

1977-01-01

The injection of an electron beam into a weakly collisional, magnetized background plasma was investigated experimentally. The injected beam was energetic and cold, the background plasma was initially isothermal. Beam and plasma dimensions were so large that the system was considered unbounded. The temporal and spatial evolution of the beam-plasma system was dominated by collective effects. High-frequency electrostatic instabilities rapidly thermalized the beam and heated the background electrons. The injected beam current was balanced by a return current consisting of background electrons drifting toward the beam source. The drift between electrons and ions gave rise to an ion acoustic instability which developed into strong three-dimensional turbulence. It was shown that the injected beam current was limited by the return current which is approximately given by the electron saturation current. Non-Maxwellian electron distribution functions were observed.

Conceptual knowledge representation: A cross-section of current research.

PubMed

Rogers, Timothy T; Wolmetz, Michael

2016-01-01

How is conceptual knowledge encoded in the brain? This special issue of Cognitive Neuropsychology takes stock of current efforts to answer this question through a variety of methods and perspectives. Across this work, three questions recur, each fundamental to knowledge representation in the mind and brain. First, what are the elements of conceptual representation? Second, to what extent are conceptual representations embodied in sensory and motor systems? Third, how are conceptual representations shaped by context, especially linguistic context? In this introductory article we provide relevant background on these themes and introduce how they are addressed by our contributing authors.

Challenges in Building Disease-Based National Health Accounts

PubMed Central

Rosen, Allison B.; Cutler, David M.

2012-01-01

Background Measuring spending on diseases is critical to assessing the value of medical care. Objective To review the current state of cost of illness (COI) estimation methods, identifying their strengths, limitations and uses. We briefly describe the current National Health Expenditure Accounts (NHEA), and then go on to discuss the addition of COI estimation to the NHEA. Conclusion Recommendations are made for future research aimed at identifying the best methods for developing and using disease-based national health accounts to optimize the information available to policymakers as they struggle with difficult resource allocation decisions. PMID:19536017

Neuroimaging for psychotherapy research: Current trends

PubMed Central

WEINGARTEN, CAROL P.; STRAUMAN, TIMOTHY J.

2014-01-01

Objective This article reviews neuroimaging studies that inform psychotherapy research. An introduction to neuroimaging methods is provided as background for the increasingly sophisticated breadth of methods and findings appearing in psychotherapy research. Method We compiled and assessed a comprehensive list of neuroimaging studies of psychotherapy outcome, along with selected examples of other types of studies that also are relevant to psychotherapy research. We emphasized magnetic resonance imaging (MRI) since it is the dominant neuroimaging modality in psychological research. Results We summarize findings from neuroimaging studies of psychotherapy outcome, including treatment for depression, obsessive-compulsive disorder (OCD), and schizophrenia. Conclusions The increasing use of neuroimaging methods in the study of psychotherapy continues to refine our understanding of both outcome and process. We suggest possible directions for future neuroimaging studies in psychotherapy research. PMID:24527694

Changes in the visual-evoked P1 potential as a function of schizotypy and background color in healthy young adults.

PubMed

Bedwell, Jeffrey S; Chan, Chi C; Trachik, Benjamin J; Rassovsky, Yuri

2013-04-01

Research has suggested a hypoactive visual magnocellular (M) pathway in individuals with schizophrenia-spectrum disorders and traits, along with a unique response of this pathway to red light. As these abnormalities only appear in a subset of these samples, they may reflect unknown subtypes with unique etiologies and corresponding neuropathologies. The P1 transient visual-evoked component has been found to be influenced by M-pathway activity; therefore, the current study assessed the P1 component in response to a 64% contrast checker stimulus on white, red, and green background conditions. The sample consisted of 28 undergraduate participants (61% male) who endorsed a continuous range of total scores from the Schizotypal Personality Questionnaire (SPQ). Participants with higher total SPQ scores had a reduced P1 mean amplitude with the white (baseline) background, which was primarily related to the SPQ Magical Thinking subscale score. In addition, while participants with lower total SPQ scores showed the expected reduction in P1 amplitude to the red (vs. green) background, participants with higher total SPQ scores showed no change, which was primarily related to the SPQ Ideas of Reference subscale. This differential change to the red background remained after covarying for the P1 amplitude to the green background, thus representing a relatively independent effect. Further confirmation of these early visual processing relationships to particular clusters of symptoms in related psychiatric samples may assist in revealing unique, currently unknown, subtypes of particular psychiatric disorders such as schizophrenia. This can direct treatment efforts toward more homogeneous neuropathology targets. Copyright © 2012 Elsevier Ltd. All rights reserved.

Enhancing Research Ethics Capacity in the Middle East: Experience and Challenges of a Fogarty-Sponsored Training Program

PubMed Central

Silverman, Henry; Edwards, Hillary; Shamoo, Adil; Matar, Amal

2014-01-01

we describe the research ethics capacity needs of the countries from the Middle East region. Against this background, we relate the experience of an international training program focused on providing long-term training in research ethics to individuals from low- and middle-income countries in the Middle East area. We describe our pedagogical approach to training, program changes to address challenges faced, and accomplishments of trainees. Many former trainees developed research ethics curricula in their home institutions, established or enhanced their institutions’ research ethics committees, provided leadership to national research ethics systems, and conducted research in research ethics. Based on our analysis, we make recommendations for how trainees can further address current regional research ethics needs in the Middle East and conduct future research. This paper is part of a collection of papers analyzing the Fogarty International Center’s International Research Ethics Education and Curriculum Development program. PMID:24384515

Looking to a future of improved diabetes management: interview with Professor Steve Bain.

PubMed

Bain, Steve

2016-12-01

Steve Bain talks to Francesca Lake, Managing Editor: Steve is currently a Professor at Swansea University Medical School (Wales), Assistant Medical Director for Research & Development for ABM University Health Board and Clinical Lead for the Diabetes Research Unit, Wales. His clinical training included research into the genetics of Type 1 diabetes, with his current clinical interests surrounding exercise in Type 1 diabetes, new therapies and the provision of diabetes services. His background has led him to be Principal Investigator for several multicenter trials, and to be involved in various ethical committees concerning genetics. He led the UK Human Genetics Commission's report on DNA testing in 2009, and in 2007 was invited to sit on the National DNA Database Ethics Group, established by the Secretary of State for the Home Department. Steve is also a member of the Wales Diabetes & Endocrine Society executive committee and chairs the Specialist Training Committee for Diabetes & Endocrinology for Wales. He also chairs the Board that oversees the Institute of Life Science Joint Clinical Research Facility, the premier clinical research institute in Wales.

Reimagining Human Research Protections for 21st Century Science

PubMed Central

Bietz, Matthew; Bae, Deborah; Bigby, Barbara; Devereaux, Mary; Fowler, James; Waldo, Ann; Weibel, Nadir; Patrick, Kevin; Klemmer, Scott; Melichar, Lori

2016-01-01

Background Evolving research practices and new forms of research enabled by technological advances require a redesigned research oversight system that respects and protects human research participants. Objective Our objective was to generate creative ideas for redesigning our current human research oversight system. Methods A total of 11 researchers and institutional review board (IRB) professionals participated in a January 2015 design thinking workshop to develop ideas for redesigning the IRB system. Results Ideas in 5 major domains were generated. The areas of focus were (1) improving the consent form and process, (2) empowering researchers to protect their participants, (3) creating a system to learn from mistakes, (4) improving IRB efficiency, and (5) facilitating review of research that leverages technological advances. Conclusions We describe the impetus for and results of a design thinking workshop to reimagine a human research protections system that is responsive to 21st century science. PMID:28007687

Preliminary measurements of 135Cs with AMS

NASA Astrophysics Data System (ADS)

Yin, Xinyi; He, Ming; Dong, Kejun; Dou, Liang; Lan, Xiaoxi; Pang, Fangfang; Wu, Shaoyong; Jiang, Shan

2015-10-01

135Cs is an interesting nuclide in many research fields, especially in environmental study. Preliminary measurements of the long-lived 135Cs with accelerator mass spectrometry (AMS) have been developed with the HI-13 tandem AMS facility at China Institute of Atomic Energy (CIAE). In order to improve ion extracting current and depressing background interference, experiments were carried out on different ions of Cs extracted from different samples. It was found that Cs- extracted from CsNO3 can be used for AMS measurement of 135Cs. According to the preliminary results, the background level can be obtained with blanks was 135Ba/Cs ∼ 8.8 × 10-12 with the CIAE-AMS system.

Current and future background ozone simulations for Mexico using a multi-scale regional climate modeling system

NASA Astrophysics Data System (ADS)

Lamb, B. K.; Gonzalez Abraham, R.; Avise, J. C.; Chung, S. H.; Salathe, E. P.; Zhang, Y.; Guenther, A. B.; Wiedinmyer, C.; Duhl, T.; Streets, D. G.

2013-05-01

Global change will clearly have a significant impact on the environment. Among the concerns for future air quality in North America, intercontinental transport of pollution has become increasingly important. In this study, we examined the effect of projected changes in Asian emissions and emissions from lightning and wildfires to produce ozone background concentrations within Mexico and the continental US. This provides a basis for developing an understanding of North American background levels and how they may change in the future. Meteorological fields were downscaled from the results of the ECHAM5 global climate model using the Weather Research Forecast (WRF) model. Two nested domains were employed, one covering most of the Northern Hemisphere from eastern Asia to North America using 220 km grid cells (semi-hemispheric domain) and one covering the continental US and northern Mexico using 36 km grid cells. Meteorological results from WRF were used to drive the MEGAN biogenic emissions model, the SMOKE emissions processing tool, and the CMAQ chemical transport model to predict ozone concentrations for current (1995-2004) and future (2045-2054) summertime conditions. The MEGAN model was used to calculate biogenic emissions for all simulations. For the semi-hemispheric domain, year 2000 global emissions of gases (ozone precursors) from anthropogenic (outside of North America), natural, and biomass burning sources from the POET and EDGAR emission inventories were used. The global tabulation for black and organic carbon (BC and OC respectively) was obtained from Bond et al. (2004) For the future decade, the current emissions were projected to the year 2050 following the Intergovernmental Panel for Climate Change (IPCC) A1B emission scenario. Anthropogenic emissions from the US, Canada, and Mexico were omitted so that only global background concentrations, and local biogenic, wildfire, and lightning emissions were treated. In this paper, we focus on background ozone levels in Mexico due to changes in future climate, local biogenic emissions and global emissions.

Gene therapy for prostate cancer: where are we now?

PubMed

Steiner, M S; Gingrich, J R

2000-10-01

The ability to recombine specifically and alter DNA sequences followed by techniques to transfer these sequences or even whole genes into normal and diseased cells has revolutionized medical research and ushered the clinicians of today into the age of gene therapy. We provide urologists a review of relevant background information, outline current treatment strategies and clinical trials, and delineate current challenges facing the field of gene therapy for advanced prostate cancer. We comprehensively reviewed the literature, including PubMed and recent abstract proceedings from national meetings, relevant to gene therapy and advanced prostate cancer. We selected for review literature representative of the principal scientific background for current gene therapy strategies and National Institutes of Health Recombinant DNA Advisory Committee approved clinical trials. Current prostate cancer gene therapy strategies include correcting aberrant gene expression, exploiting programmed cell death pathways, targeting critical cell biological functions, introducing toxic or cell lytic suicide genes, enhancing the immune system antitumor response and combining treatment with conventional cytotoxic chemotherapy or radiation therapy. Many challenges lie ahead for gene therapy, including improving DNA transfer efficiency to cells locally and at distant sites, enhancing levels of gene expression and overcoming immune responses that limit the time that genes are expressed. Nevertheless, despite these current challenges it is almost certain that gene therapy will be part of the urological armamentarium against prostate cancer in this century.

Clinical Research with Transcranial Direct Current Stimulation (tDCS): Challenges and Future Directions

PubMed Central

Brunoni, Andre Russowsky; Nitsche, Michael A.; Bolognini, Nadia; Bikson, Marom; Wagner, Tim; Merabet, Lotfi; Edwards, Dylan J.; Valero-Cabre, Antoni; Rotenberg, Alexander; Pascual-Leone, Alvaro; Ferrucci, Roberta; Priori, Alberto; Boggio, Paulo; Fregni, Felipe

2011-01-01

Background Transcranial direct current stimulation (tDCS) is a neuromodulatory technique that delivers low-intensity, direct current to cortical areas facilitating or inhibiting spontaneous neuronal activity. In the past ten years, tDCS physiological mechanisms of action have been intensively investigated giving support for the investigation of its applications in clinical neuropsychiatry and rehabilitation. However, new methodological, ethical, and regulatory issues emerge when translating the findings of preclinical and phase I studies into phase II and III clinical studies. The aim of this comprehensive review is to discuss the key challenges of this process and possible methods to address them. Methods We convened a workgroup of researchers in the field to review, discuss and provide updates and key challenges of neuromodulation use for clinical research. Main Findings/Discussion We reviewed several basic and clinical studies in the field and identified potential limitations, taking into account the particularities of the technique. We review and discuss the findings into four topics: (i) mechanisms of action of tDCS, parameters of use and computer-based human brain modeling investigating electric current fields and magnitude induced by tDCS; (ii) methodological aspects related to the clinical research of tDCS as divided according to study phase (i.e., preclinical, phase I, phase II and phase III studies); (iii) ethical and regulatory concerns; (iv) future directions regarding novel approaches, novel devices, and future studies involving tDCS. Finally, we propose some alternative methods to facilitate clinical research on tDCS. PMID:22037126

Stakeholders’ perspectives on access-to-medicines policy and research priorities in Latin America and the Caribbean: face-to-face and web-based interviews

PubMed Central

2014-01-01

Background This study aims to rank policy concerns and policy-related research issues in order to identify policy and research gaps on access to medicines (ATM) in low- and middle-income countries in Latin America and the Caribbean (LAC), as perceived by policy makers, researchers, NGO and international organization representatives, as part of a global prioritization exercise. Methods Data collection, conducted between January and May 2011, involved face-to-face interviews in El Salvador, Colombia, Dominican Republic, and Suriname, and an e-mail survey with key-stakeholders. Respondents were asked to choose the five most relevant criteria for research prioritization and to score policy/research items according to the degree to which they represented current policies, desired policies, current research topics, and/or desired research topics. Mean scores and summary rankings were obtained. Linear regressions were performed to contrast rankings concerning current and desired policies (policy gaps), and current and desired research (research gaps). Results Relevance, feasibility, and research utilization were the top ranked criteria for prioritizing research. Technical capacity, research and development for new drugs, and responsiveness, were the main policy gaps. Quality assurance, staff technical capacity, price regulation, out-of-pocket payments, and cost containment policies, were the main research gaps. There was high level of coherence between current and desired policies: coefficients of determination (R2) varied from 0.46 (Health system structure; r = 0.68, P <0.01) to 0.86 (Sustainable financing; r = 0.93, P <0.01). There was also high coherence between current and desired research on Rational selection and use of medicines (r = 0.71, P <0.05, R2 = 0.51), Pricing/affordability (r = 0.82, P <0.01, R2 = 0.67), and Sustainable financing (r = 0.76, P <0.01, R2 = 0.58). Coherence was less for Health system structure (r = 0.61, P <0.01, R2 = 0.38). Conclusions This study combines metrics approaches, contributing to priority setting methodology development, with country and regional level stakeholder participation. Stakeholders received feedback with the results, and we hope to have contributed to the discussion and implementation of ATM research and policy priorities in LAC. PMID:24965383

Life Roles, Values, and Careers. International Findings of the Work Importance Study. First Edition. The Jossey-Bass Social and Behavioral Science Series.

ERIC Educational Resources Information Center

Super, Donald E., Ed.; And Others

This book answers fundamental questions about the nature of work in modern life based on the research from an innovative, cross-national project of the Work Importance Study (WIS). Part 1 presents the background for WIS. "Studies of the Meaning of Work" (Branimir Sverko, Vlasta Vizek-Vidovic) reviews the current state of understanding of…

Proceedings of the Workshop on Gulf Stream Structure and Variability Held at Research Triangle Park, North Carolina on 1-2 April 1982.

DTIC Science & Technology

1982-04-01

Fear. Deep Sea Res., 16, 225-231. Salby, M. L., 1981: Rossby normal modes in nonuniform background configurations. Part I: Simple fields. Part II...CUJRRENT METER 1363 m~ 1/4" WIRE So - 1I? GLASS FLOATS IGO I CHAIN 720 m ANCHOR lAIR W1145141 3300 I- Fig. 2. Florida Current test mooring 325

Dispelling Myths, Restoring Hope. News Media Strategies for Reporting about African American Youth and Their Experiences with Alcohol and Other Drugs.

ERIC Educational Resources Information Center

Substance Abuse and Mental Health Services Administration (DHHS/PHS), Rockville, MD. Center for Substance Abuse Prevention.

This booklet has been prepared as a resource guide for professionals in the news business. The tools in this booklet offer new ideas for news stories about African American youth and substance abuse. The facts section offers background on the research that shapes current thinking about alcohol and other drug use. The media strategies section…

TU-F-BRD-01: Biomedical Informatics for Medical Physicists

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phillips, M; Kalet, I; McNutt, T

Biomedical informatics encompasses a very large domain of knowledge and applications. This broad and loosely defined field can make it difficult to navigate. Physicists often are called upon to provide informatics services and/or to take part in projects involving principles of the field. The purpose of the presentations in this symposium is to help medical physicists gain some knowledge about the breadth of the field and how, in the current clinical and research environment, they can participate and contribute. Three talks have been designed to give an overview from the perspective of physicists and to provide a more in-depth discussionmore » in two areas. One of the primary purposes, and the main subject of the first talk, is to help physicists achieve a perspective about the range of the topics and concepts that fall under the heading of 'informatics'. The approach is to de-mystify topics and jargon and to help physicists find resources in the field should they need them. The other talks explore two areas of biomedical informatics in more depth. The goal is to highlight two domains of intense current interest--databases and models--in enough depth into current approaches so that an adequate background for independent inquiry is achieved. These two areas will serve as good examples of how physicists, using informatics principles, can contribute to oncology practice and research. Learning Objectives: To understand how the principles of biomedical informatics are used by medical physicists. To put the relevant informatics concepts in perspective with regard to biomedicine in general. To use clinical database design as an example of biomedical informatics. To provide a solid background into the problems and issues of the design and use of data and databases in radiation oncology. To use modeling in the service of decision support systems as an example of modeling methods and data use. To provide a background into how uncertainty in our data and knowledge can be incorporated into modeling methods.« less

Search for neutrinoless double-electron capture of 156Dy

NASA Astrophysics Data System (ADS)

Finch, S. W.; Tornow, W.

2015-12-01

Background: Multiple large collaborations are currently searching for neutrinoless double-β decay, with the ultimate goal of differentiating the Majorana-Dirac nature of the neutrino. Purpose: Investigate the feasibility of resonant neutrinoless double-electron capture, an experimental alternative to neutrinoless double-β decay. Method: Two clover germanium detectors were operated underground in coincidence to search for the de-excitation γ rays of 156Gd following the neutrinoless double-electron capture of 156Dy. 231.95 d of data were collected at the Kimballton underground research facility with a 231.57 mg enriched 156Dy sample. Results: No counts were seen above background and half-life limits are set at O (1016-1018) yr for the various decay modes of 156Dy. Conclusion: Low background spectra were efficiently collected in the search for neutrinoless double-electron capture of 156Dy, although the low natural abundance and associated lack of large quantities of enriched samples hinders the experimental reach.

Felsenkeller 5 MV underground accelerator: Towards the Holy Grail of Nuclear Astrophysics 12C(α, γ)16O

NASA Astrophysics Data System (ADS)

Bemmerer, Daniel; Cowan, Thomas E.; Grieger, Marcel; Hammer, Sebastian; Hensel, Thomas; Junghans, Arnd R.; Koppitz, Martina; Ludwig, Felix; Müller, Stefan E.; Rimarzig, Bernd; Reinicke, Stefan; Schwengner, Ronald; Stöckel, Klaus; Szücs, Tamás; Takács, Marcell P.; Turkat, Steffen; Wagner, Andreas; Wagner, Louis; Zuber, Kai

2018-05-01

Low-background experiments with stable ion beams are an important tool for putting the model of stellar hydrogen, helium, and carbon burning on a solid experimental foundation. The pioneering work in this regard has been done by the LUNA collaboration at Gran Sasso, using a 0.4 MV accelerator. The present contribution reviews the status of the project for a higher-energy underground accelerator in Felsenkeller, Germany. Results from γ-ray, neutron, and muon background measurements in the Felsenkeller underground site in Dresden, Germany, show that the background conditions are satisfactory. Two tunnels of the Felsenkeller site have recently been refurbished for the installation of a 5MV high-current Pelletron accelerator. Civil construction work has completed in March 2018. The accelerator will provide intense, 50 μA, beams of 1H+, 4He+, and 12C+ ions, enabling research on astrophysically relevant nuclear reactions with unprecedented sensitivity.

Explanations of firesetting in mentally disordered offenders: a review of the literature.

PubMed

Tyler, Nichola; Gannon, Theresa A

2012-01-01

This paper reviews current explanations of firesetting in adult mentally disordered offenders. In particular, attention is given to contemporary research that has examined developmental and background characteristics, personality and associated traits, motivation for firesetting, neurobiological explanations, psychiatric diagnoses, and frequency of self-injurious behavior, including suicide. The likelihood of recidivism and associated risk factors is also considered. Evaluation of the existing research has highlighted that even though a significant proportion has been conducted with psychiatric populations, little is understood about firesetting by mentally disordered offenders. In addition, little research has been conducted that compares mentally disordered firesetters to both other mentally disordered offenders and non-mentally disordered offenders. Recommendations are made for future research to further develop knowledge of this behavior.

Recent Research Activities at the Institute of Geodesy and Geoinformatics

NASA Astrophysics Data System (ADS)

Balodis, Janis; Silabriedis, Gunars; Haritonova, Diana; Morozova, Katerina; Zarins, Ansis; Rubans, Augusts

2016-08-01

This paper discusses the research work done recently at the Institute of Geodesy and Geoinformatics of the University of Latvia. For many years the main topics of the research has been related to the satellite geodesy and to the development of the devices for satellite geodesy applications. Currently the research has been devoted to the geodynamics in Latvia: GNSS applied measurements and computation of high precision national geoid model using different data sets, analysis of Latvian GNSS permanent station position time series, development of digital zenith camera for vertical deflection determination, and development of the new multifunctional astrometric device which can be used for both the satellite laser ranging and/or for the positioning of the near Earth space bodies on the background of stars.

Symmetry breaking in SNS junctions: edge transport and field asymmetries

NASA Astrophysics Data System (ADS)

Suominen, Henri; Nichele, Fabrizio; Kjaergaard, Morten; Rasmussen, Asbjorn; Danon, Jeroen; Flensberg, Karsten; Levitov, Leonid; Shabani, Javad; Palmstrom, Chris; Marcus, Charles

We study magnetic diffraction patterns in a tunable superconductor-semiconductor-superconductor junction. By utilizing epitaxial growth of aluminum on InAs/InGaAs we obtain transparent junctions which display a conventional Fraunhofer pattern of the critical current as a function of applied perpendicular magnetic field, B⊥. By studying the angular dependence of the critical current with applied magnetic fields in the plane of the junction we find a striking anisotropy. We attribute this effect to dephasing of Andreev states in the bulk of the junction, leading to SQUID like behavior when the magnetic field is applied parallel to current flow. Furthermore, in the presence of both in-plane and perpendicular fields, asymmetries in +/-B⊥ are observed. We suggest possible origins and discuss the role of spin-orbit and Zeeman physics together with a background disorder potential breaking spatial symmetries of the junction. Research supported by Microsoft Project Q, the Danish National Research Foundation and the NSF through the National Nanotechnology Infrastructure Network.

Biological pathways, candidate genes and molecular markers associated with quality-of-life domains: an update

PubMed Central

Sprangers, Mirjam A.G.; Thong, Melissa S.Y.; Bartels, Meike; Barsevick, Andrea; Ordoñana, Juan; Shi, Qiuling; Wang, Xin Shelley; Klepstad, Pål; Wierenga, Eddy A.; Singh, Jasvinder A.; Sloan, Jeff A.

2014-01-01

Background There is compelling evidence of a genetic foundation of patient-reported QOL. Given the rapid development of substantial scientific advances in this area of research, the current paper updates and extends reviews published in 2010. Objectives The objective is to provide an updated overview of the biological pathways, candidate genes and molecular markers involved in fatigue, pain, negative (depressed mood) and positive (well-being/happiness) emotional functioning, social functioning, and overall QOL. Methods We followed a purposeful search algorithm of existing literature to capture empirical papers investigating the relationship between biological pathways and molecular markers and the identified QOL domains. Results Multiple major pathways are involved in each QOL domain. The inflammatory pathway has the strongest evidence as a controlling mechanism underlying fatigue. Inflammation and neurotransmission are key processes involved in pain perception and the COMT gene is associated with multiple sorts of pain. The neurotransmitter and neuroplasticity theories have the strongest evidence for their relationship with depression. Oxytocin-related genes and genes involved in the serotonergic and dopaminergic pathways play a role in social functioning. Inflammatory pathways, via cytokines, also play an important role in overall QOL. Conclusions Whereas the current findings need future experiments and replication efforts, they will provide researchers supportive background information when embarking on studies relating candidate genes and/or molecular markers to QOL domains. The ultimate goal of this area of research is to enhance patients’ QOL. PMID:24604075

Working Conditions of the Nursing Workforce Excerpts from a Policy Roundtable at AcademyHealth's 2003 Annual Research Meeting

PubMed Central

Hope, Hollis A

2004-01-01

The role of nursing in the delivery of health care has emerged as a complex and cross-cutting issue ripe for inquiry and multidisciplinary research. Indeed, problems in the nursing workforce have risen high on the agendas on many influential organizations, including the American Academy of Nursing, the Institute of Medicine, the National Quality Forum, The Robert Wood Johnson Foundation, and others. In an effort to clarify current research issues and advance an agenda for future investigations, Dr. Peter Buerhaus at Vanderbilt University organized a round table focused on the working conditions of the nursing workforce at the AcademyHealth 2003 Annual Research Meeting in Nashville, Tenn. Chaired by the University of California, Los Angeles, School of Public Health's Jack Needleman, the “Working Conditions of the Nursing Workforce” roundtable proved to be a provocative exchange of views among researchers and users of research. Participants shared background about their role in advancing the research, identified gaps in current research, and suggested specific areas for further research. What follows is an edited transcript of the Roundtable that, in addition to Dr. Needleman, included Ellen Kurtzman, National Quality Forum; Barbara Mark, University of North Carolina, Chapel Hill; Lori Melichar, The Robert Wood Johnson Foundation; and Donald Steinwachs, Johns Hopkins University. PMID:15149473

The historical, ethical, and legal background of human-subjects research.

PubMed

Rice, Todd W

2008-10-01

The current system of human-subject-research oversight and protections has developed over the last 5 decades. The principles of conducting human research were first developed as the Nuremberg code to try Nazi war criminals. The 3 basic elements of the Nuremberg Code (voluntary informed consent, favorable risk/benefit analysis, and right to withdraw without repercussions) became the foundation for subsequent ethical codes and research regulations. In 1964 the World Medical Association released the Declaration of Helsinki, which built on the principles of the Nuremberg Code. Numerous research improprieties between 1950 and 1974 in the United States prompted Congressional deliberations about human-subject-research oversight. Congress's first legislation to protect the rights and welfare of human subjects was the National Research Act of 1974, which created the National Commission for Protection of Human Subjects of Biomedical and Behavioral Research, which issued the Belmont Report. The Belmont Report stated 3 fundamental principles for conducting human-subjects research: respect for persons, beneficence, and justice. The Office of Human Research Protections oversees Title 45, Part 46 of the Code for Federal Regulations, which pertains to human-subjects research. That office indirectly oversees human-subjects research through local institutional review boards (IRB). Since their inception, the principles of conducting human research, IRBs, and the Code for Federal Regulations have all advanced substantially. This paper describes the history and current status of human-subjects-research regulations.

Some comments on clinical studies in orthodontics and their applications to orthodontic treatment.

PubMed

Baumrind, S

1999-06-01

This article indicates the origins and background of the current series of National Institute of Dental and Craniofacial Research-funded, university-based clinical studies of orthodontic treatment. It suggests that future studies should be less focused on refining our estimates of mean changes during treatment and concentrate research on the systematic analysis of individual differences among patients' responses to treatment, and study how skilled clinicians make in-course corrections in response to unexpected changes in treatment conditions. Finally, some suggestions are made concerning optimization of decision making in the presence of uncertainty.

Research Driven Policy: Is Financial Capacity Related to Dangerousness?

PubMed

DeLeon, Patrick H; Paxton, Maegan M; Spencer, Tonya; Bajjani-Gebara, Jouhayna E

2018-05-22

Current Veterans administration policy directly links a Veteran's adjudged capacity to manage personal financial resources with their ability to purchase or possess a firearm, pursuant to the regulatory authority of the National Instant Criminal Background Check System (NICS). Preventing Veterans' suicide is a highly laudable public health objective. Effectively utilizing scientific research to "inform" public policy is equally important. The authors should be congratulated for their efforts. However, it is important in utilizing large set population-based data, especially social science data, to evaluate policy alternatives that there be substantial face (i.e., clinical) validity. Correlation does not necessarily represent causation.

Medicinal cannabis in oncology.

PubMed

Engels, Frederike K; de Jong, Floris A; Mathijssen, Ron H J; Erkens, Joëlle A; Herings, Ron M; Verweij, Jaap

2007-12-01

In The Netherlands, since September 2003, a legal medicinal cannabis product, constituting the whole range of cannabinoids, is available for clinical research, drug development strategies, and on prescription for patients. To date, this policy, initiated by the Dutch Government, has not yet led to the desired outcome; the amount of initiated clinical research is less than expected and only a minority of patients resorts to the legal product. This review aims to discuss the background for the introduction of legal medicinal cannabis in The Netherlands, the past years of Dutch clinical experience in oncology practice, possible reasons underlying the current outcome, and future perspectives.

Current Research and Potential Applications of the Concealed Information Test: An Overview

PubMed Central

Ben-Shakhar, Gershon

2012-01-01

Research interest in psychophysiological detection of deception has significantly increased since the September 11 terror attack in the USA. In particular, the concealed information test (CIT), designed to detect memory traces that can connect suspects to a certain crime, has been extensively studied. In this paper I will briefly review several psychophysiological detection paradigms that have been studied, with a focus on the CIT. The theoretical background of the CIT, its strength and weaknesses, its potential applications as well as research finings related to its validity (based on a recent meta-analytic study), will be discussed. Several novel research directions, with a focus on factors that may affect CIT detection in realistic settings (e.g., memory for crime details; the effect of emotional stress during crime execution) will be described. Additionally, research focusing on mal-intentions and attempts to detect terror networks using information gathered from groups of suspects using both the standard CIT and the searching CIT will be reviewed. Finally, implications of current research to the actual application of the CIT will be discussed and several recommendations that can enhance the use of the CIT will be made. PMID:23060826

Conceptual design for the space station Freedom modular combustion facility

NASA Technical Reports Server (NTRS)

1989-01-01

A definition study and conceptual design for a combustion science facility that will be located in the Space Station Freedom's baseline U.S. Laboratory module is being performed. This modular, user-friendly facility, called the Modular Combustion Facility, will be available for use by industry, academic, and government research communities in the mid-1990's. The Facility will support research experiments dealing with the study of combustion and its byproducts. Because of the lack of gravity-induced convection, research into the mechanisms of combustion in the absence of gravity will help to provide a better understanding of the fundamentals of the combustion process. The background, current status, and future activities of the effort are covered.

Clinical and biomechanical perspectives on pressure injury prevention research: The case of prophylactic dressings.

PubMed

Gefen, A; Kottner, J; Santamaria, N

2016-10-01

In this perspective paper, we discuss clinical and biomechanical viewpoints on pressure injury (or pressure ulcer) prevention research. We have selected to focus on the case of prophylactic dressings for pressure injury prevention, and the background of the historical context of pressure injury research, as an exemplar to illuminate some of the good and not so good in current biomechanical and clinical research in the wound prevention and care arena. Investigators who are conducting medical or clinical research in academia, in medical settings or in industry to determine the efficacy of wound prevention and care products could benefit from applying some basic principles that are detailed in this paper, and that should leverage the research outcomes, thereby contributing to setting higher standards in the field. Copyright © 2016 Elsevier Ltd. All rights reserved.

Clinical Interventions for Hyperacusis in Adults: A Scoping Review to Assess the Current Position and Determine Priorities for Research

PubMed Central

Potgieter, Iskra; Baguley, David M.

2017-01-01

Background There is no universally accepted definition for hyperacusis, but in general it is characterised by decreased sound tolerance to ordinary environmental sounds. Despite hyperacusis being prevalent and having significant clinical implications, much remains unknown about current management strategies. Purpose To establish the current position of research on hyperacusis and identify research gaps to direct future research. Design and Sample Using an established methodological framework, electronic and manual searches of databases and journals identified 43 records that met our inclusion criteria. Incorporating content and thematic analysis approaches, the definitions of hyperacusis, management strategies, and outcome measures were catalogued. Results Only 67% of the studies provided a definition of hyperacusis, such as “reduced tolerance” or “oversensitivity to sound.” Assessments and outcome measures included Loudness Discomfort Levels, the Hyperacusis Questionnaire, and Tinnitus Retraining Therapy (TRT) interview. Management strategies reported were Cognitive Behavioural Therapy, TRT, devices, pharmacological therapy, and surgery. Conclusions Management strategies were typically evaluated in patients reporting hyperacusis as a secondary complaint or as part of a symptom set. As such the outcomes reported only provided an indication of their effectiveness for hyperacusis. Randomised Controlled Trials are needed to evaluate the effectiveness of management strategies for patients experiencing hyperacusis. PMID:29312994

Medical and Transmission Vector Vocabulary Alignment with Schema.org

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, William P.; Chappell, Alan R.; Corley, Courtney D.

Available biomedical ontologies and knowledge bases currently lack formal and standards-based interconnections between disease, disease vector, and drug treatment vocabularies. The PNNL Medical Linked Dataset (PNNL-MLD) addresses this gap. This paper describes the PNNL-MLD, which provides a unified vocabulary and dataset of drug, disease, side effect, and vector transmission background information. Currently, the PNNL-MLD combines and curates data from the following research projects: DrugBank, DailyMed, Diseasome, DisGeNet, Wikipedia Infobox, Sider, and PharmGKB. The main outcomes of this effort are a dataset aligned to Schema.org, including a parsing framework, and extensible hooks ready for integration with selected medical ontologies. The PNNL-MLDmore » enables researchers more quickly and easily to query distinct datasets. Future extensions to the PNNL-MLD will include Traditional Chinese Medicine, broader interlinks across genetic structures, a larger thesaurus of synonyms and hypernyms, explicit coding of diseases and drugs across research systems, and incorporating vector-borne transmission vocabularies.« less

A review of research on the environmental impact of e-business and ICT.

PubMed

Yi, Lan; Thomas, Hywel R

2007-08-01

This paper attempts to provide a review of the current state of the art of how e-business/ICT affects the environment. The work reviewed is in various forms including journal papers and thesis which have been peer-reviewed, as well as other resources such as projects and project reports, conference and symposia, and websites. It is claimed that the research examined has captured the most important work to date, either for a general knowledge of this new area or for background study by experts carrying out future research. The review has found that the currently dominant approach is either a micro-level case study approach or a macro-level statistical approach. It is concluded that a more predictive and empirical model, which can be applied within a sector of society, should be more beneficial in the long term. This approach should help simulate potential impacts resulting from changes of indicators, so that positive effects can be promoted and negative ones alleviated proactively, rather than knowing and accepting outcomes passively.

Health Inequalities among Workers with a Foreign Background in Sweden: Do Working Conditions Matter?

PubMed Central

Dunlavy, Andrea C.; Rostila, Mikael

2013-01-01

Employment and working conditions are key social determinants of health, yet current information is lacking regarding relationships between foreign background status, working conditions and health among workers in Sweden. This study utilized cross-sectional data from the 2010 Swedish Level of Living Survey (LNU) and the Level of Living Survey for Foreign Born Persons and their Children (LNU-UFB) to assess whether or not health inequalities exist between native Swedish and foreign background workers and if exposure to adverse psychosocial and physical working conditions contributes to the risk for poor health among foreign background workers. A sub-sample of 4,021 employed individuals aged 18–65 was analyzed using logistic regression. Eastern European, Latin American and Other Non-Western workers had an increased risk of both poor self-rated health and mental distress compared to native Swedish workers. Exposure to adverse working conditions only minimally influenced the risk of poor health. Further research should examine workers who are less integrated or who have less secure labor market attachments and also investigate how additional working conditions may influence associations between health and foreign background status. PMID:23846669

DEVELOPMENT OF CHINESE HEALTH LAW: OVERVIEW AND SUGGESTIONS.

PubMed

Liu, Kai; Tang, Daolu

2014-07-01

Health law is a rapidly developing law specialty in China. This article examines the current overall framework and evolution of Chinese health law, as a background to an analysis of the advantages and disadvantages of this legal regime. Research suggests that: 1) The independent status of Chinese health law as jurisprudence and a specialty ought to be assured altogether; 2) The convergence between health law and other laws should be strengthened; 3) The current Chinese health law framework ought to be completed. This suggests the necessity to find ways to improve the independence of health law in China by eliminating the convergence and completing the legal framework.

Selected methods for quantification of community exposure to aircraft noise

NASA Technical Reports Server (NTRS)

Edge, P. M., Jr.; Cawthorn, J. M.

1976-01-01

A review of the state-of-the-art for the quantification of community exposure to aircraft noise is presented. Physical aspects, people response considerations, and practicalities of useful application of scales of measure are included. Historical background up through the current technology is briefly presented. The developments of both single-event and multiple-event scales are covered. Selective choice is made of scales currently in the forefront of interest and recommended methodology is presented for use in computer programing to translate aircraft noise data into predictions of community noise exposure. Brief consideration is given to future programing developments and to supportive research needs.

Current Source Mapping by Spontaneous MEG and ECoG in Piglets Model

PubMed Central

Gao, Lin; Wang, Jue; Stephen, Julia; Zhang, Tongsheng

2016-01-01

The previous research reveals the presence of relatively strong spatial correlations from spontaneous activity over cortex in Electroencephalography (EEG) and Magnetoencephalography (MEG) measurement. A critical obstacle in MEG current source mapping is that strong background activity masks the relatively weak local information. In this paper, the hypothesis is that the dominant components of this background activity can be captured by the first Principal Component (PC) after employing Principal Component Analysis (PCA), thus discarding the first PC before the back projection would enhance the exposure of the information carried by a subset of sensors that reflects the local neuronal activity. By detecting MEG signals densely (one measurement per 2×2 mm2) in three piglets neocortical models over an area of 18×26 mm2 with a special shape of lesion by means of a μSQUID, this basic idea was demonstrated by the fact that a strong activity could be imaged in the lesion region after removing the first PC in Delta, Theta and Alpha band, while the original recordings did not show such activity clearly. Thus, the PCA decomposition can be employed to expose the local activity, which is around the lesion in the piglets’ neocortical models, by removing the dominant components of the background activity. PMID:27570537

Bilogical effects of ionizing radiation: epidemiological surveys and laboratory animal experiments. Implications for risk evaluation and decision processes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fabrikant, J.I.

1981-04-01

General background is given for an understanding of the potential health effects in populations exposed to low-level ionizing radiations. The discussion is within the framework of the scientific deliberations and controversies that arose during preparation of the current report of the committee on the biological effects of ionizing radiation of the National Academy of Science - National Research Council (1980 Beir-III Report). (ACR)

Theoretical Exploration of the Neural Bases of Behavioural Disinhibition, Apathy and Executive Dysfunction in Preclinical Alzheimer's Disease in People with Down's Syndrome: Potential Involvement of Multiple Frontal-Subcortical Neuronal Circuits

ERIC Educational Resources Information Center

Ball, S. L.; Holland, A. J.; Watson, P. C.; Huppert, F. A.

2010-01-01

Background: Recent research has suggested a specific impairment in frontal-lobe functioning in the preclinical stages of Alzheimer's disease (AD) in people with Down's syndrome (DS), characterised by prominent changes in personality or behaviour. The aim of the current paper is to explore whether particular kinds of change (namely executive…

Autonomy Community of Interest (COI) Test and Evaluation, Verification and Validation (TEVV) Working Group: Technology Investment Strategy 2015-2018

DTIC Science & Technology

2015-05-01

Evaluation Center of Excellence SUAS Small Unmanned Aircraft System SUT System under Test T&E Test and Evaluation TARDEC Tank Automotive Research...17 Distribution A: Distribution Unlimited 2 Background In the past decade, unmanned systems have significantly impacted warfare...environments at a speed and scale beyond manned capability. However, current unmanned systems operate with minimal autonomy. To meet warfighter needs and

An Exploration of the Differing Perceptions of Problem-Based Learning (PBL) from Students and Facilitators of Diverse Cultural Backgrounds, in the Fields of Theological and Nursing Education

ERIC Educational Resources Information Center

Fung, Nancy L. Y.

2013-01-01

Theological education has not widely utilized the PBL approach and there is very little research examining the utility of PBL in theological education. Lectures are currently the preferred teaching method in theological education, however, it is recognized that there is a need for a more holistic approach. As theological education is used in both…

Small transport aircraft technology. A report for the committee on commerce, science, and transportation, United States Senate

NASA Technical Reports Server (NTRS)

1979-01-01

A preliminary assessment of the research and technology that NASA could undertake to improve small transport aircraft is presented. The advanced technologies currently under study for potential application to the small transport aircraft of the future are outlined. Background information on the commuter and shorthaul local service air carriers, the regulations pertaining to their aircraft and operations, and the overall airline system interface is included.

A Readout Integrated Circuit (ROIC) employing self-adaptive background current compensation technique for Infrared Focal Plane Array (IRFPA)

NASA Astrophysics Data System (ADS)

Zhou, Tong; Zhao, Jian; He, Yong; Jiang, Bo; Su, Yan

2018-05-01

A novel self-adaptive background current compensation circuit applied to infrared focal plane array is proposed in this paper, which can compensate the background current generated in different conditions. Designed double-threshold detection strategy is to estimate and eliminate the background currents, which could significantly reduce the hardware overhead and improve the uniformity among different pixels. In addition, the circuit is well compatible to various categories of infrared thermo-sensitive materials. The testing results of a 4 × 4 experimental chip showed that the proposed circuit achieves high precision, wide application and high intelligence. Tape-out of the 320 × 240 readout circuit, as well as the bonding, encapsulation and imaging verification of uncooled infrared focal plane array, have also been completed.

CUORE and Background Reduction Case Studies for CUPID

NASA Astrophysics Data System (ADS)

Sakai, Michinari; Gozlukluoglu, Nihal; Huang, Huan; Cuore Collaboration

2017-09-01

CUORE (Cryogenic Underground Observatory for Rare Events) is a bolometric experiment at cryogenic temperatures currently in operation to search for neutrinoless double beta decay. Successful detection of this extremely rare process requires stringent control of radioactive backgrounds of the experiment as well as the detector itself. Great care was taken in CUORE to select the materials and various parts that comprise the current detector. However next-generation neutrinoless double beta decay experiments face a challenge to further reduce backgrounds in order to probe more deeply into the effective Majorana neutrino mass phase space. In this presentation we will review the sensitivity and background budget for the currently running experiment CUORE, as well as the target sensitivity and background goals for the next generation experiment CUPID that will cover the inverted neutrino mass hierarchy. We will explore simulation based R&D case studies for background reduction and lay out achievable background reduction levels using possible materials and feasible geometries in the context of CUPID. National Science Foundation.

Laser-induced fluorescence imaging of bacteria

NASA Astrophysics Data System (ADS)

Hilton, Peter J.

1998-12-01

This paper outlines a method for optically detecting bacteria on various backgrounds, such as meat, by imaging their laser induced auto-fluorescence response. This method can potentially operate in real-time, which is many times faster than current bacterial detection methods, which require culturing of bacterial samples. This paper describes the imaging technique employed whereby a laser spot is scanned across an object while capturing, filtering, and digitizing the returned light. Preliminary results of the bacterial auto-fluorescence are reported and plans for future research are discussed. The results to date are encouraging with six of the eight bacterial strains investigated exhibiting auto-fluorescence when excited at 488 nm. Discrimination of these bacterial strains against red meat is shown and techniques for reducing background fluorescence discussed.

Pigs in Toxicology: Breed Differences in Metabolism and Background Findings.

PubMed

Helke, Kristi L; Nelson, Keith N; Sargeant, Aaron M; Jacob, Binod; McKeag, Sean; Haruna, Julius; Vemireddi, Vimala; Greeley, Melanie; Brocksmith, Derek; Navratil, Nicole; Stricker-Krongrad, Alain; Hollinger, Charlotte

2016-06-01

Both a rodent and a nonrodent species are required for evaluation in nonclinical safety studies conducted to support human clinical trials. Historically, dogs and nonhuman primates have been the nonrodent species of choice. Swine, especially the miniature swine or minipigs, are increasingly being used in preclinical safety as an alternate nonrodent species. The pig is an appropriate option for these toxicology studies based on metabolic pathways utilized in xenobiotic biotransformation. Both similarities and differences exist in phase I and phase II biotransformation pathways between humans and pigs. There are numerous breeds of pigs, yet only a few of these breeds are characterized with regard to both xenobiotic-metabolizing enzymes and background pathology findings. Some specific differences in these enzymes based on breed and sex are known. Although swine have been used extensively in biomedical research, there is also a paucity of information in the current literature detailing the incidence of background lesions and differences between commonly used breeds. Here, the xenobiotic-metabolizing enzymes are compared between humans and pigs, and minipig background pathology changes are reviewed with emphasis on breed differences. © The Author(s) 2016.

Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status?12

PubMed Central

Rosanoff, Andrea; Dai, Qi; Shapses, Sue A

2016-01-01

Although much is known about magnesium, its interactions with calcium and vitamin D are less well studied. Magnesium intake is low in populations who consume modern processed-food diets. Low magnesium intake is associated with chronic diseases of global concern [e.g., cardiovascular disease (CVD), type 2 diabetes, metabolic syndrome, and skeletal disorders], as is low vitamin D status. No simple, reliable biomarker for whole-body magnesium status is currently available, which makes clinical assessment and interpretation of human magnesium research difficult. Between 1977 and 2012, US calcium intakes increased at a rate 2–2.5 times that of magnesium intakes, resulting in a dietary calcium to magnesium intake ratio of >3.0. Calcium to magnesium ratios <1.7 and >2.8 can be detrimental, and optimal ratios may be ∼2.0. Background calcium to magnesium ratios can affect studies of either mineral alone. For example, US studies (background Ca:Mg >3.0) showed benefits of high dietary or supplemental magnesium for CVD, whereas similar Chinese studies (background Ca:Mg <1.7) showed increased risks of CVD. Oral vitamin D is widely recommended in US age-sex groups with low dietary magnesium. Magnesium is a cofactor for vitamin D biosynthesis, transport, and activation; and vitamin D and magnesium studies both showed associations with several of the same chronic diseases. Research on possible magnesium and vitamin D interactions in these human diseases is currently rare. Increasing calcium to magnesium intake ratios, coupled with calcium and vitamin D supplementation coincident with suboptimal magnesium intakes, may have unknown health implications. Interactions of low magnesium status with calcium and vitamin D, especially during supplementation, require further study. PMID:26773013

Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status?

PubMed

Rosanoff, Andrea; Dai, Qi; Shapses, Sue A

2016-01-01

Although much is known about magnesium, its interactions with calcium and vitamin D are less well studied. Magnesium intake is low in populations who consume modern processed-food diets. Low magnesium intake is associated with chronic diseases of global concern [e.g., cardiovascular disease (CVD), type 2 diabetes, metabolic syndrome, and skeletal disorders], as is low vitamin D status. No simple, reliable biomarker for whole-body magnesium status is currently available, which makes clinical assessment and interpretation of human magnesium research difficult. Between 1977 and 2012, US calcium intakes increased at a rate 2-2.5 times that of magnesium intakes, resulting in a dietary calcium to magnesium intake ratio of >3.0. Calcium to magnesium ratios <1.7 and >2.8 can be detrimental, and optimal ratios may be ∼2.0. Background calcium to magnesium ratios can affect studies of either mineral alone. For example, US studies (background Ca:Mg >3.0) showed benefits of high dietary or supplemental magnesium for CVD, whereas similar Chinese studies (background Ca:Mg <1.7) showed increased risks of CVD. Oral vitamin D is widely recommended in US age-sex groups with low dietary magnesium. Magnesium is a cofactor for vitamin D biosynthesis, transport, and activation; and vitamin D and magnesium studies both showed associations with several of the same chronic diseases. Research on possible magnesium and vitamin D interactions in these human diseases is currently rare. Increasing calcium to magnesium intake ratios, coupled with calcium and vitamin D supplementation coincident with suboptimal magnesium intakes, may have unknown health implications. Interactions of low magnesium status with calcium and vitamin D, especially during supplementation, require further study. © 2016 American Society for Nutrition.

Significance chasing in research practice: Causes, consequences, and possible solutions

PubMed Central

Ware, Jennifer J.; Munafò, Marcus R.

2016-01-01

Background and Aims The low reproducibility of findings within the scientific literature is a growing concern. This may be due to many findings being false positives, which in turn can misdirect research effort and waste money. Methods We review factors that may contribute to poor study reproducibility and an excess of ‘significant’ findings within the published literature. Specifically, we consider the influence of current incentive structures, and the impact of these on research practices. Results The prevalence of false positives within the literature may be attributable to a number of questionable research practices, ranging from the relatively innocent and minor (e.g., unplanned post hoc tests), to the calculated and serious (e.g., fabrication of data). These practices may be driven by current incentive structures (e.g. pressure to publish), alongside the preferential emphasis placed by journals on novelty over veracity. There are a number of potential solutions to poor reproducibility, such as new publishing formats that emphasise the research question and study design, rather than the results obtained. This has the potential to minimise significance chasing and non-publication of null findings. Conclusions Significance chasing, questionable research practices, and poor study reproducibility are the unfortunate consequence of a “publish or perish” culture and a preference among journals for novel findings. It is likely that top-down change implemented by those with the ability to modify current incentive structure (e.g., funders and journals) will be required to address problems of poor reproducibility. PMID:25040652

Protective orders: questions and conundrums.

PubMed

Logan, T K; Shannon, Lisa; Walker, Robert; Faragher, Teri Marie

2006-07-01

Current media portrayal of protective orders is often negative, focusing on weaknesses in how protective orders are obtained and enforced. This review of research findings on protective orders examines issues and suggests areas in need of future research to clarify and improve public policy. More specifically, this review has five main objectives: (a) to provide background information about partner violence and the need for protective orders; (b) to describe what protective orders are, how many women obtain them, and the advantages and disadvantages of obtaining protective orders; (c) to examine characteristics of women who seek protective orders; (d) to explore research on whether protective orders actually increase women's safety; and (e) to highlight opportunities and gaps in the practice and research literature regarding the use of protective orders for women with violent partners or ex-partners.

Health, human rights, and the conduct of clinical research within oppressed populations

PubMed Central

Mills, Edward J; Singh, Sonal

2007-01-01

Background Clinical trials evaluating interventions for infectious diseases require enrolling participants that are vulnerable to infection. As clinical trials are conducted in increasingly vulnerable populations, issues of protection of these populations become challenging. In settings where populations are forseeably oppressed, the conduct of research requires considerations that go beyond common ethical concerns and into issues of international human rights law. Discussion Using examples of HIV prevention trials in Thailand, hepatitis-E prevention trials in Nepal and malaria therapeutic trials in Burma (Myanmar), we address the inadequacies of current ethical guidelines when conducting research within oppressed populations. We review existing legislature in the United States and United Kingdom that may be used against foreign investigators if trial hardships exist. We conclude by making considerations for research conducted within oppressed populations. PMID:17996056

One Health training, research, and outreach in North America

PubMed Central

Stroud, Cheryl; Kaplan, Bruce; Logan, Jenae E.

2016-01-01

Background The One Health (OH) concept, formerly referred to as ‘One Medicine’ in the later part of the 20th century, has gained exceptional popularity in the early 21st century, and numerous academic and non-academic institutions have developed One Health programs. Objectives To summarize One Health training, research, and outreach activities originating in North America. Methods We used data from extensive electronic records maintained by the One Health Commission (OHC) (www.onehealthcommission.org/) and the One Health Initiative (www.onehealthinitiative.com/) and from web-based searches, combined with the corporate knowledge of the authors and their professional contacts. Finally, a call was released to members of the OHC's Global One Health Community listserv, asking that they populate a Google document with information on One Health training, research, and outreach activities in North American academic and non-academic institutions. Results A current snapshot of North American One Health training, research, and outreach activities as of August 2016 has evolved. Conclusions It is clear that the One Health concept has gained considerable recognition during the first decade of the 21st century, with numerous current training and research activities carried out among North American academic, non-academic, government, corporate, and non-profit entities. PMID:27906120

Numerical simulation of large-scale field-aligned current generation from finite-amplitude magnetosonic waves

NASA Technical Reports Server (NTRS)

Yamauchi, M.

1994-01-01

A two-dimensional numerical simulation of finite-amplitude magnetohydrodynamic (MHD) magnetosonic waves is performed under a finite-velocity background convection condition. Isothermal cases are considered for simplicity. External dissipation is introduced by assuming that the field-aligned currents are generated in proportion to the accumulated charges. The simulation results are as follows: Paired field-aligned currents are found from the simulated waves. The flow directions of these field-aligned currents depend on the angle between the background convection and the wave normal, and hence two pairs of field-aligned currents are found from a bowed wave if we look at the overall structure. The majority of these field-aligned currents are closed within each pair rather than between two wings. These features are not observed under slow background convection. The result could be applied to the cusp current system and the substorm current system.

Photogrammetry and optical methods in structural dynamics - A review

NASA Astrophysics Data System (ADS)

Baqersad, Javad; Poozesh, Peyman; Niezrecki, Christopher; Avitabile, Peter

2017-03-01

In the last few decades, there has been a surge of research in the area of non-contact measurement techniques. Photogrammetry has received considerable attention due to its ability to achieve full-field measurement and its robustness to work in testing environments and on testing articles in which using other measurement techniques may not be practical. More recently, researchers have used this technique to study transient phenomena and to perform measurements on vibrating structures. The current paper reviews the most current trends in the photogrammetry technique (point tracking, digital image correlation, and target-less approaches) and compares the applications of photogrammetry to other measurement techniques used in structural dynamics (e.g. laser Doppler vibrometry and interferometry techniques). The paper does not present the theoretical background of the optical techniques, but instead presents the general principles of each approach and highlights the novel structural dynamic measurement concepts and applications that are enhanced by utilizing optical techniques.

Countercurrent Separation of Natural Products: An Update

PubMed Central

2015-01-01

This work assesses the current instrumentation, method development, and applications in countercurrent chromatography (CCC) and centrifugal partition chromatography (CPC), collectively referred to as countercurrent separation (CCS). The article provides a critical review of the CCS literature from 2007 since our last review (J. Nat. Prod.2008, 71, 1489–1508), with a special emphasis on the applications of CCS in natural products research. The current state of CCS is reviewed in regard to three continuing topics (instrumentation, solvent system development, theory) and three new topics (optimization of parameters, workflow, bioactivity applications). The goals of this review are to deliver the necessary background with references for an up-to-date perspective of CCS, to point out its potential for the natural product scientist, and thereby to induce new applications in natural product chemistry, metabolome, and drug discovery research involving organisms from terrestrial and marine sources. PMID:26177360

The "Ethics Rupture" Summit, Fredericton, New Brunswick, Canada, October 25-28, 2012.

PubMed

van den Hoonaard, Will C

2013-02-01

This report explains the background of the "Ethics Rupture" Summit held in New Brunswick, Canada, October 2012, focusing on the disconnect between research-ethics policies and the nature and purpose of social-science research-an unintended "rupture" in ethics governance. Ethics is about human relationships, and the governance of ethics must reflect that fact rather than function as a bureaucratic, self-legitimating system of control. The themes that emerged from the Summit point to: structural problems with the current system; an undermining of the original, historical mission of some social-science disciplines; a discomfort with new methodologies; ethics committees and the well-being and education of social-science students; the possibilities of reform and renewal; and the next steps. Finally, the report refers in broad outlines to a "New Brunswick Declaration," which is currently being considered by participants of the Summit.

Endpoints and cutpoints in head and neck oncology trials: methodical background, challenges, current practice and perspectives.

PubMed

Hezel, Marcus; von Usslar, Kathrin; Kurzweg, Thiemo; Lörincz, Balazs B; Knecht, Rainald

2016-04-01

This article reviews the methodical and statistical basics of designing a trial, with a special focus on the process of defining and choosing endpoints and cutpoints as the foundations of clinical research, and ultimately that of evidence-based medicine. There has been a significant progress in the treatment of head and neck cancer in the past few decades. Currently available treatment options can have a variety of different goals, depending e.g. on tumor stage, among other factors. The outcome of a specific treatment in clinical trials is measured using endpoints. Besides classical endpoints, such as overall survival or organ preservation, other endpoints like quality of life are becoming increasingly important in designing and conducting a trial. The present work is based on electronic research and focuses on the solid methodical and statistical basics of a clinical trial, on the structure of study designs and on the presentation of various endpoints.

Focus on Fluorides: Update on the Use of Fluoride for the Prevention of Dental Caries

PubMed Central

Carey, Clifton M.

2014-01-01

Declarative Title: Improving the efficacy of fluoride therapies reduces dental caries and lowers fluoride exposure. Background Fluoride is delivered to the teeth systemically or topically to aid in the prevention of dental caries. Systemic fluoride from ingested sources is in blood serum and can be deposited only in teeth that are forming in children. Topical fluoride is from sources such as community water, processed foods, beverages, toothpastes, mouthrinses, gels, foams, and varnishes. The United States Centers for Disease Control and Prevention (CDC) and the American Dental Association (ADA) have proposed changes in their long standing recommendations for the amount of fluoride in community drinking water in response to concerns about an increasing incidence of dental fluorosis in children. Current research is focused on the development of strategies to improve fluoride efficacy. The purpose of this update is to inform the reader about new research and policies related to the use of fluoride for the prevention of dental caries. Methods Reviews of the current research and recent evidence based systematic reviews on the topics of fluoride are presented. Topics discussed include: updates on community water fluoridation research and policies; available fluoride in dentifrices; fluoride varnish compositions, use, and recommendations; and other fluoride containing dental products. This update provides insights into current research and discusses proposed policy changes for the use of fluoride for the prevention of dental caries. Conclusions The dental profession is adjusting their recommendations for fluoride use based on current observations of the halo effect and subsequent outcomes. The research community is focused on improving the efficacy of fluoride therapies thus reducing dental caries and lowering the amount of fluoride required for efficacy. PMID:24929594

Current Sheet Formation in a Conical Theta Pinch Faraday Accelerator with Radio-frequency Assisted Discharge

NASA Technical Reports Server (NTRS)

Polzin, Kurt A.; Hallock, Ashley K.; Choueiri, Edgar Y.

2008-01-01

Data from an inductive conical theta pinch accelerator are presented to gain insight into the process of inductive current sheet formation in the presence of a preionized background gas produced by a steady-state RF-discharge. The presence of a preionized plasma has been previously shown to allow for current sheet formation at lower discharge voltages and energies than those found in other pulsed inductive accelerator concepts, leading to greater accelerator efficiencies at lower power levels. Time-resolved magnetic probe measurements are obtained for different background pressures and pulse energies to characterize the effects of these parameters on current sheet formation. Indices are defined that describe time-resolved current sheet characteristics, such as the total current owing in the current sheet, the time-integrated total current ('strength'), and current sheet velocity. It is found that for a given electric field strength, maximums in total current, strength, and velocity occur for one particular background pressure. At other pressures, these current sheet indices are considerably smaller. The trends observed in these indices are explained in terms of the principles behind Townsend breakdown that lead to a dependence on the ratio of the electric field to the background pressure. Time-integrated photographic data are also obtained at the same experimental conditions, and qualitatively they compare quite favorably with the time-resolved magnetic field data.

Are Patents Impeding Medical Care and Innovation?

PubMed Central

Gold, E. Richard; Kaplan, Warren; Orbinski, James; Harland-Logan, Sarah; N-Marandi, Sevil

2010-01-01

Background to the debate: Pharmaceutical and medical device manufacturers argue that the current patent system is crucial for stimulating research and development (R&D), leading to new products that improve medical care. The financial return on their investments that is afforded by patent protection, they claim, is an incentive toward innovation and reinvestment into further R&D. But this view has been challenged in recent years. Many commentators argue that patents are stifling biomedical research, for example by preventing researchers from accessing patented materials or methods they need for their studies. Patents have also been blamed for impeding medical care by raising prices of essential medicines, such as antiretroviral drugs, in poor countries. This debate examines whether and how patents are impeding health care and innovation. PMID:20052274

A Spatial and Temporal Characterization of the Background Neutron Environment at the Navy and Marine Corps Memorial Stadium

DTIC Science & Technology

2017-04-01

developing informed survey protocols. Experimental Method The neutron detector used in this research was the Large Neutron Sensor (LNS), containing...are useful in planning, conducting, and assessing the utility and limitations of radiation surveys using current state-of-the-art portable or...34,000. In a security environment, where large public venues may be a target for terrorist activity, the ability to survey venues for radio- logical

Basics of Bayesian methods.

PubMed

Ghosh, Sujit K

2010-01-01

Bayesian methods are rapidly becoming popular tools for making statistical inference in various fields of science including biology, engineering, finance, and genetics. One of the key aspects of Bayesian inferential method is its logical foundation that provides a coherent framework to utilize not only empirical but also scientific information available to a researcher. Prior knowledge arising from scientific background, expert judgment, or previously collected data is used to build a prior distribution which is then combined with current data via the likelihood function to characterize the current state of knowledge using the so-called posterior distribution. Bayesian methods allow the use of models of complex physical phenomena that were previously too difficult to estimate (e.g., using asymptotic approximations). Bayesian methods offer a means of more fully understanding issues that are central to many practical problems by allowing researchers to build integrated models based on hierarchical conditional distributions that can be estimated even with limited amounts of data. Furthermore, advances in numerical integration methods, particularly those based on Monte Carlo methods, have made it possible to compute the optimal Bayes estimators. However, there is a reasonably wide gap between the background of the empirically trained scientists and the full weight of Bayesian statistical inference. Hence, one of the goals of this chapter is to bridge the gap by offering elementary to advanced concepts that emphasize linkages between standard approaches and full probability modeling via Bayesian methods.

Method for technology-delivered healthcare measures.

PubMed

Kramer-Jackman, Kelli Lee; Popkess-Vawter, Sue

2011-12-01

Current healthcare literature lacks development and evaluation methods for research and practice measures administered by technology. Researchers with varying levels of informatics experience are developing technology-delivered measures because of the numerous advantages they offer. Hasty development of technology-delivered measures can present issues that negatively influence administration and psychometric properties. The Method for Technology-delivered Healthcare Measures is designed to systematically guide the development and evaluation of technology-delivered measures. The five-step Method for Technology-delivered Healthcare Measures includes establishment of content, e-Health literacy, technology delivery, expert usability, and participant usability. Background information and Method for Technology-delivered Healthcare Measures steps are detailed.

The path to impact of operational research on tuberculosis control policies and practices in Indonesia

PubMed Central

Probandari, Ari; Widjanarko, Bagoes; Mahendradhata, Yodi; Sanjoto, Hary; Cerisha, Ancila; Nungky, Saverina; Riono, Pandu; Simon, Sumanto; Farid, Muhammad Noor; Giriputra, Sardikin; Putra, Artawan Eka; Burhan, Erlina; Wahyuni, Chatarina U.; Mustikawati, Dyah; Widianingrum, Christina; Tiemersma, Edine W.; Alisjahbana, Bachti

2016-01-01

Background Operational research is currently one of the pillars of the global strategy to control tuberculosis. Indonesia initiated capacity building for operational research on tuberculosis over the last decade. Although publication of the research in peer-reviewed journals is an important indicator for measuring the success of this endeavor, the influence of operational research on policy and practices is considered even more important. However, little is known about the process by which operational research influences tuberculosis control policy and practices. Objective We aimed to investigate the influence of operational research on tuberculosis control policy and practice in Indonesia between 2004 and 2014. Design Using a qualitative study design, we conducted in-depth interviews of 50 researchers and 30 policy makers/program managers and performed document reviews. Transcripts of these interviews were evaluated while applying content analysis. Results Operational research contributed to tuberculosis control policy and practice improvements, including development of new policies, introduction of new practices, and reinforcement of current program policies and practices. However, most of these developments had limited sustainability. The path from the dissemination of research results and recommendations to policy and practice changes was long and complex. The skills, interests, and political power of researchers and policy makers, as well as health system response, could influence the process. Conclusions Operational research contributed to improving tuberculosis control policy and practices. A systematic approach to improve the sustainability of the impact of operational research should be explored. PMID:26928217

Influence of background noise on the performance in the odor sensitivity task: effects of noise type and extraversion.

PubMed

Seo, Han-Seok; Hähner, Antje; Gudziol, Volker; Scheibe, Mandy; Hummel, Thomas

2012-10-01

Recent research demonstrated that background noise relative to silence impaired subjects' performance in a cognitively driven odor discrimination test. The current study aimed to investigate whether the background noise can also modulate performance in an odor sensitivity task that is less cognitively loaded. Previous studies have shown that the effect of background noise on task performance can be different in relation to degree of extraversion and/or type of noise. Accordingly, we wanted to examine whether the influence of background noise on the odor sensitivity task can be altered as a function of the type of background noise (i.e., nonverbal vs. verbal noise) and the degree of extraversion (i.e., introvert vs. extrovert group). Subjects were asked to conduct an odor sensitivity task in the presence of either nonverbal noise (e.g., party sound) or verbal noise (e.g., audio book), or silence. Overall, the subjects' mean performance in the odor sensitivity task was not significantly different across three auditory conditions. However, with regard to the odor sensitivity task, a significant interaction emerged between the type of background noise and the degree of extraversion. Specifically, verbal noise relative to silence significantly impaired or improved the performance of the odor sensitivity task in the introvert or extrovert group, respectively; the differential effect of introversion/extraversion was not observed in the nonverbal noise-induced task performance. In conclusion, our findings provide new empirical evidence that type of background noise and degree of extraversion play an important role in modulating the effect of background noise on subjects' performance in an odor sensitivity task.

Reverse Current Shock Induced by Plasma-Neutral Collision

NASA Astrophysics Data System (ADS)

Wongwaitayakornkul, Pakorn; Haw, Magnus; Li, Hui; Li, Shengtai; Bellan, Paul

2017-10-01

The Caltech solar experiment creates an arched plasma-filled flux rope expanding into low density background plasma. A layer of electrical current flowing in the opposite direction with respect to the flux rope current is induced in the background plasma just ahead of the flux rope. Two dimensional spatial and temporal measurements by a 3-dimensional magnetic vector probe demonstrate the existence of this induced current layer forming ahead of the flux rope. The induced current magnitude is 20% of the magnitude of the current in the flux rope. The reverse current in the low density background plasma is thought to be a diamagnetic response that shields out the magnetic field ahead of the propagation. The spatial and magnetic characteristics of the reverse current layer are consistent with similar shock structures seen in 3-dimensional ideal MHD numerical simulations performed on the Turquoise supercomputer cluster using the Los Alamos COMPutational Astrophysics Simulation Suite. This discovery of the induced diamagnetic current provides useful insights for space and solar plasma.

2014 Section on Pediatrics Knowledge translation Lecture: Clinicians and researchers on the same path toward facilitating family goals for mobility & participation

PubMed Central

Damiano, Diane L.; Leonard, Rebecca

2015-01-01

BACKGROUND The Knowledge Translation (KT) Lecture at CSM 2014 was a personal perspective from a researcher who had been a therapist and a longtime clinician, now a Ph.D. candidate. OBJECTIVE To better integrate research and clinical care, so KT is a seamless rather than separate process. KEY POINTS KT can be enhanced by improved receptivity to evidence, and increasing use of research designs that encourage and even require clinician involvement, from single-subject designs to large-scale pragmatic trials. Clinical practice databases and hiring therapists to provide intervention in research efforts also serve to integrate research and clinical care. Limitations of applying mean group research results to an individual patient were also discussed and suggest an important unanswered topic for future research. CONCLUSION We all need to assume responsibility for the researcher-clinician partnership, making our jobs more joyful and fulfilling, and hopefully the biggest beneficiaries will be our current and future patients. PMID:25822350

Losing Your Gut Feelings. Intuition in Depression

PubMed Central

Remmers, Carina; Michalak, Johannes

2016-01-01

Whereas in basic research, intuition has become a topic of great interest, clinical research and depression research in specific have not applied to the topic of intuition, yet. This is astonishing because a well-known phenomenon during depression is that patients have difficulties to judge and decide. In contrast to healthy individuals who take most daily life decisions intuitively (Kahneman, 2011), depressed individuals seem to have difficulties to come to fast and adaptive decisions. The current article pursues three goals. First, our aim is to establish the hypothesis that intuition is impaired in depression against the background of influential theoretical accounts as well as empirical evidence from basic and clinical research. The second aim of the current paper is to provide explanations for recent findings on the depression-intuition interplay and to present directions for future research that may help to broaden our understanding of decision difficulties in depression. Third, we seek to propose ideas on how therapeutic interventions can support depressed individuals in taking better decisions. Even though our knowledge regarding this topic is still limited, we will tentatively launch the idea that an important first step may be to enhance patients’ access to intuitions. Overall, this paper seeks to introduce the topic of intuition to clinical research on depression and to hereby set the stage for upcoming theory and practice. PMID:27602015

Losing Your Gut Feelings. Intuition in Depression.

PubMed

Remmers, Carina; Michalak, Johannes

2016-01-01

Whereas in basic research, intuition has become a topic of great interest, clinical research and depression research in specific have not applied to the topic of intuition, yet. This is astonishing because a well-known phenomenon during depression is that patients have difficulties to judge and decide. In contrast to healthy individuals who take most daily life decisions intuitively (Kahneman, 2011), depressed individuals seem to have difficulties to come to fast and adaptive decisions. The current article pursues three goals. First, our aim is to establish the hypothesis that intuition is impaired in depression against the background of influential theoretical accounts as well as empirical evidence from basic and clinical research. The second aim of the current paper is to provide explanations for recent findings on the depression-intuition interplay and to present directions for future research that may help to broaden our understanding of decision difficulties in depression. Third, we seek to propose ideas on how therapeutic interventions can support depressed individuals in taking better decisions. Even though our knowledge regarding this topic is still limited, we will tentatively launch the idea that an important first step may be to enhance patients' access to intuitions. Overall, this paper seeks to introduce the topic of intuition to clinical research on depression and to hereby set the stage for upcoming theory and practice.

International Youth Conference on the Poles

NASA Astrophysics Data System (ADS)

Church, A. K.; Kuhn, T. S.; Baeseman, J.; Garmulewicz, A.; Raymond, M.; Salmon, R.

2006-12-01

The International Polar Year (IPY) is an international effort, involving more than 50 countries, to focus research in both the sciences and social sciences on the world's Polar Regions. In order to secure youth involvement in the IPY, the Youth Steering Committee (YSC) has been formed, aiming specifically to network young polar researchers from all backgrounds enabling collaboration and to involve this group in outreach focused towards other young people. A conference targeted directly at an audience of early career researchers and international youth will be central to fulfilling these aims. The YSC has therefore developed the concept of the International Youth Conference on the Poles (IYCP). Proposed for 2008, this conference will bring together youth from a diverse set of backgrounds and nationalities to discuss the issues affecting the Polar Regions, their effects on a global scale and ways of addressing these issues. The conference will also serve to highlight ongoing IPY research, especially research being undertaken by young researchers, and provide a perennial framework for youth involvement in polar research and policies. The IYCP will run for three days in May 2008, attracting an international youth audience, as well as representatives from polar organizations, teachers, politicians, policy makers, the general public and media. The IYCP will be divided into three sections. Youth Roundtable Discussions will bring youth together to discuss issues affecting the Polar Regions and potential solutions to these. A Young Researchers Conference will provide the opportunity for young researchers working in the Polar Regions to present their work to an interdisciplinary audience. The Polar Fair will provide an interactive environment for youth to learn about the Polar Regions. The IYCP will be of great importance to the IPY because it will serve as the principle venue during the Polar Year where youth from many different disciplines, backgrounds and countries will be able to gather and interact. It will inspire many young people to become more actively involved in polar research and issues, while reinforcing for those currently undertaking these endeavours the importance of their contribution.

Taking stock of current societal, political and academic stakeholders in the Canadian healthcare knowledge translation agenda

PubMed Central

Newton, Mandi S; Scott-Findlay, Shannon

2007-01-01

Background In the past 15 years, knowledge translation in healthcare has emerged as a multifaceted and complex agenda. Theoretical and polemical discussions, the development of a science to study and measure the effects of translating research evidence into healthcare, and the role of key stakeholders including academe, healthcare decision-makers, the public, and government funding bodies have brought scholarly, organizational, social, and political dimensions to the agenda. Objective This paper discusses the current knowledge translation agenda in Canadian healthcare and how elements in this agenda shape the discovery and translation of health knowledge. Discussion The current knowledge translation agenda in Canadian healthcare involves the influence of values, priorities, and people; stakes which greatly shape the discovery of research knowledge and how it is or is not instituted in healthcare delivery. As this agenda continues to take shape and direction, ensuring that it is accountable for its influences is essential and should be at the forefront of concern to the Canadian public and healthcare community. This transparency will allow for scrutiny, debate, and improvements in health knowledge discovery and health services delivery. PMID:17916256

Food Parenting: A Selective Review of Current Measurement and an Empirical Examination To Inform Future Measurement

PubMed Central

Kiefner, Allison

2013-01-01

Abstract Background Interactions between parents and children in regard to food are an important part of the development of food preferences and intake patterns for children. The measurement of this complex and multidimensional construct is very challenging. Methods This article examines the current status of measurement in this domain in a selective review, considers qualitative input from parents and adolescents in an empirical examination of the topic, and makes concrete recommendations for the future. Results Qualitatively, there were important differences between what the adolescents reported that their parents did to impact their eating habits, what parents of younger children report they currently do, and what researchers typically measure in research on parental feeding practices. Conclusions On the basis of these empirical findings and our review of the literature, we recommend that food parenting be measured on three levels: Feeding styles (e.g., authoritative), food parenting practices (e.g., restriction), and specific feeding behaviors (e.g., putting food out of the child's reach). Specific recommendations for future study are given for each level of measurement. PMID:23944922

Detection methods for stochastic gravitational-wave backgrounds: a unified treatment

NASA Astrophysics Data System (ADS)

Romano, Joseph D.; Cornish, Neil. J.

2017-04-01

We review detection methods that are currently in use or have been proposed to search for a stochastic background of gravitational radiation. We consider both Bayesian and frequentist searches using ground-based and space-based laser interferometers, spacecraft Doppler tracking, and pulsar timing arrays; and we allow for anisotropy, non-Gaussianity, and non-standard polarization states. Our focus is on relevant data analysis issues, and not on the particular astrophysical or early Universe sources that might give rise to such backgrounds. We provide a unified treatment of these searches at the level of detector response functions, detection sensitivity curves, and, more generally, at the level of the likelihood function, since the choice of signal and noise models and prior probability distributions are actually what define the search. Pedagogical examples are given whenever possible to compare and contrast different approaches. We have tried to make the article as self-contained and comprehensive as possible, targeting graduate students and new researchers looking to enter this field.

Focal plane infrared readout circuit with automatic background suppression

NASA Technical Reports Server (NTRS)

Pain, Bedabrata (Inventor); Yang, Guang (Inventor); Sun, Chao (Inventor); Shaw, Timothy J. (Inventor); Wrigley, Chris J. (Inventor)

2002-01-01

A circuit for reading out a signal from an infrared detector includes a current-mode background-signal subtracting circuit having a current memory which can be enabled to sample and store a dark level signal from the infrared detector during a calibration phase. The signal stored by the current memory is subtracted from a signal received from the infrared detector during an imaging phase. The circuit also includes a buffered direct injection input circuit and a differential voltage readout section. By performing most of the background signal estimation and subtraction in a current mode, a low gain can be provided by the buffered direct injection input circuit to keep the gain of the background signal relatively small, while a higher gain is provided by the differential voltage readout circuit. An array of such readout circuits can be used in an imager having an array of infrared detectors. The readout circuits can provide a high effective handling capacity.

Advances in the prevention of oral disease; the role of the International Association for Dental Research

PubMed Central

2015-01-01

Abstract Background Since its foundation in 1920, prevention of oral disease has been a priority for the International Association for Dental Research (IADR) and the commitment of the organisation to the subject area is clearly expressed in its mission to improve oral health worldwide. The IADR has a current global membership of almost 11,000 people who share an interest in oral and craniofacial research. Contribution of IADR This paper provides an overview of the contribution of IADR to supporting research and associated activities in disease prevention, in disseminating knowledge and in advocating for better oral health for all citizens of the world. It looks back over time and summarises current supports. Two more recent initiatives in disease prevention are described in more detail, the Global Oral Health Inequalities Research Agenda (GOHIRA) and the proceedings at the 2013 World Conference on Preventive Dentistry (WCPD, 2013), a joint initiative between IADR and WHO. Through organisational structure, meetings, publications, scientific groups and networks and external relations, IADR has been at the forefront of advancing research for the prevention of oral diseases. Conclusions IADR is committed to ensuring research advances get disseminated and implemented and at the same time encourages and advocates for basic, clinical and translational research across disciplines so that we may uncover the major breakthrough in prevention of oral disease. PMID:26391001

The barriers and facilitators people with diabetes from a nonEnglish speaking background experience when managing their medications: a qualitative study.

PubMed

Claydon-Platt, Kate; Manias, Elizabeth; Dunning, Trisha

2014-08-01

To explore the barriers to and facilitators of effective medication management from the perspectives of people with diabetes from a nonEnglish speaking background, carers and health professionals. The barriers that people with diabetes experience managing their medications can adversely impact on health outcomes. People from nonEnglish speaking backgrounds are at risk of medication-related problems, although there is a paucity of research in this area. A qualitative research design using a purposive sampling approach. People with type 1 or type 2 diabetes from a nonEnglish speaking background, their carers, and health professionals who assisted these people and their carers to manage their medications were recruited from the diabetes outpatient clinic at an adult teaching public hospital in Melbourne, Australia. Participants were interviewed using a semi-structured interview guide. All interviews were audio-recorded, transcribed verbatim and analysed using a thematic framework method. Eleven people with diabetes, 10 carers and 10 health professionals were interviewed, and four key issues were identified: diabetes knowledge, diabetes impact, medication knowledge and medication management. The cost of medications, language barriers that hinder communication, forgetfulness, and poor knowledge and understanding emerged as barriers to effective medication management. Facilitators included the use of dose administration aids to manage medications, but current medication lists were not used. Findings revealed people with diabetes experienced a multitude of barriers when managing their medications, and, despite the problems people experienced, there appeared to be poor use of support aids to assist people to effectively manage their medications. The findings can be used to develop strategies aiming at improving how people from nonEnglish speaking backgrounds manage their medicines. © 2013 John Wiley & Sons Ltd.

Acute Ethanol Has Biphasic Effects on Short- and Long-Term Memory in Both Foreground and Background Contextual Fear Conditioning in C57BL/6 Mice

PubMed Central

Gulick, Danielle; Gould, Thomas J.

2009-01-01

Background Ethanol is a frequently abused, addictive drug that impairs cognitive function. Ethanol may disrupt cognitive processes by altering attention, short-term memory, and/ or long-term memory. Interestingly, some research suggests that ethanol may enhance cognitive processes at lower doses. The current research examined the dose-dependent effects of ethanol on contextual and cued fear conditioning. In addition, the present studies assessed the importance of stimulus salience in the effects of ethanol and directly compared the effects of ethanol on short-term and long-term memory. Methods This study employed both foreground and background fear conditioning, which differ in the salience of contextual stimuli, and tested conditioning at 4 hours, 24 hours, and 1 week in order to assess the effects of ethanol on short-term and long-term memory. Foreground conditioning consisted of 2 presentations of a foot shock unconditioned stimulus (US) (2 seconds, 0.57 mA). Background conditioning consisted of 2 auditory conditioned stimulus (30 seconds, 85 dB white noise)–foot shock (US; 2 seconds, 0.57 mA) pairings. Results For both foreground and background conditioning, ethanol enhanced short-term and long-term memory for contextual and cued conditioning at a low dose (0.25 g/kg) and impaired short-term and long-term memory for contextual and cued conditioning at a high dose (1.0 g/kg). Conclusions These results suggest that ethanol has long-lasting, biphasic effects on short-term and long-term memory for contextual and cued conditioning. Furthermore, the effects of ethanol on contextual fear conditioning are independent of the salience of the context. PMID:17760787

Widening access to medicine may improve general practitioner recruitment in deprived and rural communities: survey of GP origins and current place of work.

PubMed

Dowell, J; Norbury, M; Steven, K; Guthrie, B

2015-10-01

Widening access to medicine in the UK is a recalcitrant problem of increasing political importance, with associated strong social justice arguments but without clear evidence of impact on service delivery. Evidence from the United States suggests that widening access may enhance care to underserved communities. Additionally, rural origin has been demonstrated to be the factor most strongly associated with rural practice. However the evidence regarding socio-economic and rural background and subsequent practice locations in the UK has not been explored. The aim of this study was to investigate the association between general practitioners' (GPs) socio-economic and rural background at application to medical school and demographic characteristics of their current practice. The study design was a cross-sectional email survey of general practitioners practising in Scotland. Socio-economic status of GPs at application to medical school was assessed using the self-coded National Statistics Socio-Economic Classification. UK postcode at application was used to define urban-rural location. Current practice deprivation and remoteness was measured using NHS Scotland defined measures based on registered patients' postcodes. A survey was sent to 2050 Scottish GPs with a valid accessible email address, with 801 (41.5 %) responding. GPs whose parents had semi-routine or routine occupations had 4.3 times the odds of working in a deprived practice compared to those with parents from managerial and professional occupations (95 % CI 1.8-10.2, p = 0.001). GPs from remote and rural Scottish backgrounds were more likely to work in remote Scottish practices, as were GPs originating from other UK countries. This study showed that childhood background is associated with the population GPs subsequently serve, implying that widening access may positively affect service delivery in addition to any social justice rationale. Longitudinal research is needed to explore this association and the impact of widening access on service delivery more broadly.

Effects of background color and symbol arrangement cues on construction of multi-symbol messages by young children without disabilities: implications for aided AAC design.

PubMed

Thistle, Jennifer J; Wilkinson, Krista

2017-09-01

Children whose speech does not meet their communication needs often benefit from augmentative and alternative communication (AAC). The design of an AAC display may influence the child's ability to communicate effectively. The current study examined how symbol background color cues and symbol arrangement affected construction of multi-symbol messages using line-drawing symbols, by young children with typical development. Participants (N = 52) heard a spoken phrase matching a photograph and selected line drawings within a 4 × 4 array. Friedman two-way ANOVAs evaluated speed and accuracy of multi-symbol message construction under four conditions in which the background color and arrangement of symbols was manipulated. Participants demonstrated significantly faster response times when symbols were arranged by word-class category compared to no symbol arrangement. The majority of children responded faster when symbols had white backgrounds, but this effect failed to reach statistical significance. This study provides preliminary evidence suggesting the importance of symbol arrangement for young children. The findings highlight the need for caution when incorporating background color on displays for young children. Future research is needed to examine the effect of visual cues on children who use AAC and consider additional factors that could influence efficacy of symbol arrangement and background color use.

A review of contrast pattern based data mining

NASA Astrophysics Data System (ADS)

Zhu, Shiwei; Ju, Meilong; Yu, Junfeng; Cai, Binlei; Wang, Aiping

2015-07-01

Contrast pattern based data mining is concerned with the mining of patterns and models that contrast two or more datasets. Contrast patterns can describe similarities or differences between the datasets. They represent strong contrast knowledge and have been shown to be very successful for constructing accurate and robust clusters and classifiers. The increasing use of contrast pattern data mining has initiated a great deal of research and development attempts in the field of data mining. A comprehensive revision on the existing contrast pattern based data mining research is given in this paper. They are generally categorized into background and representation, definitions and mining algorithms, contrast pattern based classification, clustering, and other applications, the research trends in future. The primary of this paper is to server as a glossary for interested researchers to have an overall picture on the current contrast based data mining development and identify their potential research direction to future investigation.

Engagement and Retention of Suicide Attempters in Clinical Research

PubMed Central

Gibbons, Carly J.; Stirman, Shannon Wiltsey; Brown, Gregory K.; Beck, Aaron T.

2010-01-01

Background High attrition rates in longitudinal research can limit study generalizability, threaten internal validity, and decrease statistical power. Research has demonstrated that there can be significant differences between participants who complete a research study and those who drop out prematurely, and that treatment outcomes may be dependent on retention in a treatment protocol. Aims The current paper describes the challenges encountered when implementing a randomized controlled trial of cognitive therapy for the prevention of suicide attempts and the solutions developed to overcome these problems. Methods Problems unique to suicide attempters are discussed, and strategies successfully implemented to boost retention rates are provided. Results The methods implemented appeared to increase retention rates in the randomized controlled trial. Conclusions Many steps can be taken to work with this difficult population, and researchers are encouraged to be as involved and flexible with participants as possible. PMID:20418211

Physical oceanography and tracer chemistry of the southern ocean

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

This report considers technical and scientific developments and research questions in studies of the Southern Ocean since its predecessor, /open quotes/Southern Ocean Dynamics--A Strategy for Scientific Exploration 1973-1983/close quotes/ was published. The summary lists key research questions in Southern Ocean oceanography. Chapter 1 describes how Southern Ocean research has evolved to provide the basis for timely research toward more directed objectives. Chapter 2 recommends four research programs, encompassing many of the specific recommendations that follow. Appendix A provides the scientific background and Reference/Bibliography list for this report for: on air-sea-ice interaction; the Antarctic Circumpolar Current; water mass conversion; chemical tracermore » oceanography; and numerical modeling of the Southern Ocean. Appendix B describes the satellite-based observation systems expected to be active during the next decade. Appendix C is a list of relevant reports published during 1981-1987. 146 refs.« less

Informed consent for MRI and fMRI research: Analysis of a sample of Canadian consent documents

PubMed Central

2011-01-01

Background Research ethics and the measures deployed to ensure ethical oversight of research (e.g., informed consent forms, ethics review) are vested with extremely important ethical and practical goals. Accordingly, these measures need to function effectively in real-world research and to follow high level standards. Methods We examined approved consent forms for Magnetic Resonance Imaging (MRI) and functional Magnetic Resonance Imaging (fMRI) studies approved by Canadian research ethics boards (REBs). Results We found evidence of variability in consent forms in matters of physical and psychological risk reporting. Approaches used to tackle the emerging issue of incidental findings exposed extensive variability between and within research sites. Conclusion The causes of variability in approved consent forms and studies need to be better understood. However, mounting evidence of administrative and practical hurdles within current ethics governance systems combined with potential sub-optimal provision of information to and protection of research subjects support other calls for more scrutiny of research ethics practices and applicable revisions. PMID:21235768

The research imperative revisited: considerations for advancing the debate surrounding medical research as moral imperative.

PubMed

Wayne, Katherine; Glass, Kathleen Cranley

2010-01-01

Medical research is frequently regarded as not only laudable, but even obligatory. However, the moral foundation for such an obligation is far from clear. Lively debate concerning the viability of an obligation to conduct and support medical research is transpiring among a small number of scholars speaking from a variety of backgrounds, yet the current discussion is predominantly situated within several discrete academic and professional circles, allowing only sporadic engagement within and between scholarly disciplines and the medical realm. We aim to lay the groundwork for a focused critique of the "research imperative" by examining (1) its commitments within ideologies of science, medicine, and progress: and (2) its normative theoretical underpinnings. Our analysis finds no solid grounding for the research imperative and exposes problems in the attitudes and arguments supporting it. We believe these concerns present compelling reasons for devoting greater critical attention to the research imperative and to the morality of the medical research enterprise as a whole.

National Aeronautics and Space Administration (NASA)/American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program, 1998. Volume 1

NASA Technical Reports Server (NTRS)

Bannerot, Richard B. (Editor); Sickorez, Donn G. (Editor)

1999-01-01

JSC NASA/ASEE Summer Faculty Fellowship Program was conducted by the University of Houston and JSC, under ASEE. The objectives of the program are to further the professional knowledge of qualified engineering and science members; stimulate an exchange of ideas between participants and NASA; enrich and refresh the research and teaching activities of participants; and contribute to the research objectives of the NASA Centers. Each faculty fellow spent at least 10 weeks at JSC engaged in a research project commensurate with his/her interests and background and worked in collaboration with a NASA/JSC colleague. This document is a compilation of the final reports on the fellows' research projects performed during the summer of 1998. Volume 1, current volume, contains the first reports, and volume 2 contains the remaining reports.

Performance, Facility Pressure Effects, and Stability Characterization Tests of NASA's Hall Effect Rocket with Magnetic Shielding Thruster

NASA Technical Reports Server (NTRS)

Kamhawi, Hani; Huang, Wensheng; Haag, Thomas; Yim, John; Herman, Daniel; Peterson, Peter Y.; Williams, George J.; Gilland, James; Hofer, Richard; Mikellides, Ioannis

2016-01-01

NASA's Hall Effect Rocket with Magnetic Shielding (HERMeS) 12.5 kW Technology Demonstration Unit-1 (TDU-1) has been the subject of extensive technology maturation in preparation for flight system development. Part of the technology maturation effort included experimental evaluation of the TDU-1 thruster with conducting and dielectric front pole cover materials in two different electrical configurations. A graphite front magnetic pole cover thruster configuration with the thruster body electrically tied to cathode, and an alumina front pole cover thruster configuration with the thruster body floating were evaluated. Both configurations were also evaluated at different facility background pressure conditions to evaluate background pressure effects on thruster operation. Performance characterization tests found that higher thruster performance was attained with the graphite front pole cover configuration with the thruster electrically tied to cathode. A total thrust efficiency of 68% and a total specific impulse of 2,820 s was demonstrated at a discharge voltage of 600 V and a discharge power of 12.5 kW. Thruster stability regimes were characterized with respect to the thruster discharge current oscillations and with maps of the discharge current-voltage-magnetic field (IVB). Analysis of TDU-1 discharge current waveforms found that lower normalized discharge current peak-to-peak and root mean square magnitudes were attained when the thruster was electrically floated with alumina front pole covers. Background pressure effects characterization tests indicated that the thruster performance and stability were mostly invariant to changes in the facility background pressure for vacuum chamber pressure below 1×10-5 Torr-Xe (for thruster flow rates of 20.5 mg/s). Power spectral density analysis of the discharge current waveforms showed that increasing the vacuum chamber background pressure resulted in a higher discharge current dominant breathing mode frequency. Finally, IVB maps of the TDU-1 thruster indicated that the discharge current became more oscillatory with higher discharge current peak-to-peak and RMS values with increased facility background pressure at lower thruster mass flow rates; thruster operation at higher flow rates resulted in less change to the thruster's IVB characteristics with elevated background pressure.

Bridging the Gap: The Role of DOD in Clean Energy Commercialization: DOD Installations as Living Laboratories

DTIC Science & Technology

2010-08-17

Director of ERDC is Dr. Jeffery P. Holland. ERDC/CERL TR-10-13 1 1 Introduction Background The impacts of current high levels of energy consumption...use of renewable/alternative energy 4. Assured access to sufficient energy supplies 5. Reduced adverse impacts on the environment. ERDC/CERL TR-10...Environmental Impact Statement EISA U.S. Energy Independence and Security Act of 2007 EPACT Energy Policy Act of 2005 ERDC Engineer Research and

Discussion on the management system technology implementation of multimedia classrooms in the digital campus

NASA Astrophysics Data System (ADS)

Wang, Bo

2018-04-01

Based on the digitized information and network, digital campus is an integration of teaching, management, science and research, life service and technology service, and it is one of the current mainstream construction form of campus function. This paper regarded the "mobile computing" core digital environment construction development as the background, explored the multiple management system technology content design and achievement of multimedia classrooms in digital campus and scientifically proved the technology superiority of management system.

Cooper-Harper Experience Report for Spacecraft Handling Qualities Applications

NASA Technical Reports Server (NTRS)

Bailey, Randall E.; Jackson, E. Bruce; Bilimoria, Karl D.; Mueller, Eric R.; Frost, Chad R.; Alderete, Thomas S.

2009-01-01

A synopsis of experience from the fixed-wing and rotary-wing aircraft communities in handling qualities development and the use of the Cooper-Harper pilot rating scale is presented as background for spacecraft handling qualities research, development, test, and evaluation (RDT&E). In addition, handling qualities experiences and lessons-learned from previous United States (US) spacecraft developments are reviewed. This report is intended to provide a central location for references, best practices, and lessons-learned to guide current and future spacecraft handling qualities RDT&E.

[Genetic and epigenetic aspects of celiac disease].

PubMed

Kocsis, Dorottya; Béres, Nóra; Veres, Gábor; Szabó, Dolóresz; Müller, Katalin Eszter; Arató, András; Juhász, Márk

2014-01-19

Genetic background of coeliac disease has been subjects to intensive research since decades. However, only results of HLA phenotyping have been taken over to routine clinical practice. Meanwhile, data on the role of epigenetical factors in the manifestation of diseases have been emerging. In coeliac disease, there are several questions both in the fields of genetics and epigenetics yet to be answered. In this review, a cross section of current knowledge on these issues is presented with special interest regarding the future clinical applications.

Frontal Polymerization in Microgravity Summary of Research

NASA Technical Reports Server (NTRS)

Pojman, John A.

2002-01-01

The project began with frontal polymerization (FP). We studied many aspects of FP on the ground and performed two successful weeks of flying on the KC-135. The project evolved into the current flight investigation, Transient Interfacial Phenomena in Miscible Polymer Systems (TIPMPS), as we recognized that an essential question could best be studied using a non-frontal approach. We present detailed results from our ground-based work on FP, KC-135 results and the background, justification and numerical work for the TIPMPS project.

Strategic Plan. Volume 1

NASA Technical Reports Server (NTRS)

2002-01-01

The purpose of this document is to present the strategic plan and associated organizational structure that the National Space Biomedical Research Institute (NSBRI) will utilize to achieve the defined mission and objectives provided by NASA. Much of the information regarding the background and establishment of the NSBRI by NASA has been provided in other documentation and will not be repeated in this Strategic Plan. This Strategic Plan is presented in two volumes. Volume I (this volume) begins with an Introduction (Section 2) that provides the Institute's NASA-defined mission and objectives, and the organizational structure adopted to implement these through three Strategic Programs: Countermeasure Research; Education, Training and Outreach; and Cooperative Research and Development. These programs are described in Sections 3 to 5. Each program is presented in a similar way, using four subsections: Goals and Objectives; Current Strategies; Gaps and Modifications; and Resource Requirements. Section 6 provides the administrative infrastructure and total budget required to implement the Strategic Programs and assures that they form a single cohesive plan. This plan will ensure continued success of the Institute for the next five years. Volume II of the Strategic Plan provides an in-depth analysis of the current and future strategic programs of the 12 current NSBRI teams, including their goals, objectives, mutual interactions and schedules.

Standardising Responsibility? The Significance of Interstitial Spaces.

PubMed

Wickson, Fern; Forsberg, Ellen-Marie

2015-10-01

Modern society is characterised by rapid technological development that is often socially controversial and plagued by extensive scientific uncertainty concerning its socio-ecological impacts. Within this context, the concept of 'responsible research and innovation' (RRI) is currently rising to prominence in international discourse concerning science and technology governance. As this emerging concept of RRI begins to be enacted through instruments, approaches, and initiatives, it is valuable to explore what it is coming to mean for and in practice. In this paper we draw attention to a realm that is often backgrounded in the current discussions of RRI but which has a highly significant impact on scientific research, innovation and policy-namely, the interstitial space of international standardization. Drawing on the case of nanoscale sciences and technologies to make our argument, we present examples of how international standards are already entangled in the development of RRI and yet, how the process of international standardization itself largely fails to embody the norms proposed as characterizing RRI. We suggest that although current models for RRI provide a promising attempt to make research and innovation more responsive to societal needs, ethical values and environmental challenges, such approaches will need to encompass and address a greater diversity of innovation system agents and spaces if they are to prove successful in their aims.

A systematic review of psychosocial interventions for adult refugees and asylum seekers.

PubMed

Tribe, Rachel H; Sendt, Kyra-Verena; Tracy, Derek K

2017-05-09

Europe is in the midst of the largest refugee migration since the Second World War; there is an urgent need to provide an updated systematic review of the current best evidence for managing mental distress in refugee populations. The aim of this review is to provide an exhaustive summary of the current literature on psychosocial interventions, both trauma- and non-trauma-focused, for refugee populations experiencing post-traumatic stress disorder (PTSD), depressive or anxiety symptoms. To produce recommendations for future research and current clinical practice. Searches were conducted in PubMed, PsychINFO (Hosted by Ovid), PILOTS and Social Services Abstracts; 5305 articles were screened and 40 were included. This review found medium to high quality evidence supporting the use of narrative exposure therapy (NET). A lack of culturally adapted treatments was apparent and there was less evidence to support standard cognitive behavioural therapy (CBT), Eye Movement Desensitisation and Reprocessing (EMDR) and multidisciplinary treatments. NET produced positive outcomes in refugees from a diverse range of backgrounds and trauma types. There is a general dearth of research in all intervention types: further research should include more "real-world" multidisciplinary interventions that better model clinical practice. Recommendations for evaluating local need, and creating a culturally sensitive workforce are discussed.

Health effects associated with exposure to ambient air pollution.

PubMed

Samet, Jonathan; Krewski, Daniel

2007-02-01

The World Health Organization has identified ambient air pollution as a high public health priority, based on estimates of air pollution related death and disability-adjusted life years derived in its Global Burden of Disease initiative. The NERAM Colloquium Series on Health and Air Quality was initiated to strengthen the linkage between scientists, policymakers, and other stakeholders by reviewing the current state of science, identifying policy-relevant gaps and uncertainties in the scientific evidence, and proposing a path forward for research and policy to improve air quality and public health. The objective of this paper is to review the current state of science addressing the impacts of air pollution on human health. The paper is one of four background papers prepared for the 2003 NERAM/AirNet Conference on Strategies for Clean Air and Health, the third meeting in the international Colloquium Series. The review is based on the framework and findings of the U.S. National Research Committee (NRC) on Research Priorities for Airborne Particulate Matter and addresses key questions underlying air quality risk management policy decisions.

HgCdTe 256x256 NWIR FPA

NASA Technical Reports Server (NTRS)

Vural, Kadri; Blessinger, Michael; Chen, Jenkon; Kleinhans, William

1989-01-01

Researchers developed a HgCdTe 256x256 focal plane array (FPA) which operates in the 1 to 5 micron band. This is presently the largest demonstrated HgCdTe FPA. The detector material is HgCdTe on sapphire (PACE-1 technology) which has a low thermal expansion mismatch with silicon. The multiplexer is a CMOS FET-switch device processed through a commercial silicon foundry. The multiplexer input is direct injection and the charge capacity is about 2 times 10 to the 7th power electrons. The kTC limited read noise is 400 electrons. Researchers demonstrated high background imaging using the device. The broadband quantum efficiency is measured to be 59 percent. Dark currents less than 0.1 pA were measured at 77 K for detectors processed on PACE-1 material with 4.9 microns cutoff. The dark currents decrease as the temperature is lowered, and researchers are presently studying the T less than 77 K characteristics. The interconnect yield is greater than 95 percent. The devices are available for astronomical applications.

Emotion Socialization and Ethnicity: An Examination of Practices and Outcomes in African American, Asian American, and Latin American Families

PubMed Central

Morelen, Diana; Thomassin, Kristel

2013-01-01

The current review paper summarizes the literature on parental emotion socialization in ethnically diverse families in the United States. Models of emotion socialization have been primarily developed using samples of European American parents and children. As such, current categorizations of “adaptive” and “maladaptive” emotion socialization practices may not be applicable to individuals from different ethnic backgrounds. The review examines current models of emotion socialization, with particular attention paid to the demographic breakdown of the studies used to develop these models. Additionally, the review highlights studies examining emotion socialization practices in African American, Asian American, and Latin American families. The review is synthesized with summarizing themes of similarities and differences across ethnic groups, and implications for culturally sensitive research and practice are discussed. PMID:23766738

Menstrual hygiene management among adolescent schoolgirls in low- and middle-income countries: research priorities

PubMed Central

Phillips-Howard, Penelope A.; Caruso, Bethany; Torondel, Belen; Zulaika, Garazi; Sahin, Murat; Sommer, Marni

2016-01-01

Background A lack of adequate guidance on menstrual management; water, disposal, and private changing facilities; and sanitary hygiene materials in low- and middle-income countries leaves schoolgirls with limited options for healthy personal hygiene during monthly menses. While a plethora of observational studies have described how menstrual hygiene management (MHM) barriers in school impact girls’ dignity, well-being, and engagement in school activities, studies have yet to confirm if inadequate information and facilities for MHM significantly affects quantifiable school and health outcomes influencing girls’ life chances. Evidence on these hard outcomes will take time to accrue; however, a current lack of standardized methods, tools, and research funding is hampering progress and must be addressed. Objectives Compile research priorities for MHM and types of research methods that can be used. Results In this article, we highlight the current knowledge gaps in school-aged girls’ MHM research, and identify opportunities for addressing the dearth of hard evidence limiting the ability of governments, donors, and other agencies to appropriately target resources. We outline a series of research priorities and methodologies that were drawn from an expert panel to address global priorities for MHM in schools for the next 10 years. Conclusions A strong evidence base for different settings, standardized definitions regarding MHM outcomes, improved study designs and methodologies, and the creation of an MHM research consortia to focus attention on this neglected global issue. PMID:27938648

Solar thermal technical information guide

NASA Astrophysics Data System (ADS)

1985-05-01

This guide is designed to help investigators search for information in the solar thermal technology field. The information ranges from history and technology basics to the latest in research and develoment. It is written to help several audiences, including engineers and scientists who may be unfamiliar with a particular aspect of solar thermal energy, university researchers who are interested in the field, manufacturers needing to learn more about specific topics, and librarians who provide information to their clientele. The guide is divided into ten chapters, with Chapters 1 to 8 providing background on solar thermal energy development (including its history and current status) by topic. Within each topic, an overview is provided with references to relevant publications or information sources. Chapters 9 and 10 contain directories listing research centers and major technical information sources, respectively.

Report from the National Institute of Allergy and Infectious Disease Workshop on Drug Allergy

PubMed Central

Wheatley, Lisa M; Plaut, Marshall; Schwaninger, Julie M; Banerji, Aleena; Castells, Mariana; Finkelman, Fred D.; Gleich, Gerald J.; Guttman-Yassky, Emma; Mallal, Simon A.K.; Naisbitt, Dean J.; Ostrov, David A.; Phillips, Elizabeth J.; Pichler, Werner J.; Platts-Mills, Thomas A. E.; Roujeau, Jean-Claude; Schwartz, Lawrence B.; Trepanier, Lauren A.

2015-01-01

Allergic reactions to drugs are a serious public health concern. In 2013, the National Institute of Allergy and Infectious Diseases, Division of Allergy, Immunology and Transplantation, sponsored a workshop on drug allergy. International experts in the field of drug allergy with backgrounds in allergy, immunology, infectious diseases, dermatology, clinical pharmacology and pharmacogenomics discussed the current state of drug allergy research. These experts were joined by representatives from several NIH Institutes and the U.S. Food and Drug Administration (FDA). The participants identified important advances that make new research directions feasible and made suggestions for research priorities and for development of infrastructure to advance our knowledge of the mechanisms, diagnosis, management, and prevention of drug allergy. The workshop summary and recommendations are presented herein. PMID:26254053

Authoritarian parenting attitudes and social origin: The multigenerational relationship of socioeconomic position to childrearing values.

PubMed

Friedson, Michael

2016-01-01

Support for authoritarian approaches to parenting, including corporal punishment, is known to be elevated among individuals with low current levels of socioeconomic attainment. The objectives of this study are: (1) to determine whether authoritarian parenting dispositions are related to disadvantages in one's social background, in addition to one's present socioeconomic standing; and (2) to distinguish, in this regard, between support for spanking and other authoritarian parenting dispositions. Ordered logit models, applied to General Social Survey data concerning a nationally representative sample of US adults, are used to examine relationships of authoritarian parenting dispositions to the socioeconomic positions that respondents currently occupy and in which they were raised. It is found that support for spanking (N=10,725) and valuing of obedience (N=10,043) are inversely related to the socioeconomic status (SES) of one's family of origin, and that these associations are robust to controls for one's current SES. A disadvantaged family background is found to increase support for spanking most among those with high current SES. Strong associations (robust to controls for SES indicators) are additionally found between African-American racial identity and support for authoritarian parenting. Prior research indicates that authoritarian parenting practices such as spanking may be harmful to children. Thus, if the parenting attitudes analyzed here translate into parenting practices, then this study's findings may point to a mechanism for the intergenerational transmission of disadvantages. Copyright © 2015 Elsevier Ltd. All rights reserved.

Zero-gravity cloud physics.

NASA Technical Reports Server (NTRS)

Hollinden, A. B.; Eaton, L. R.; Vaughan, W. W.

1972-01-01

The first results of an ongoing preliminary-concept and detailed-feasibility study of a zero-gravity earth-orbital cloud physics research facility are reviewed. Current planning and thinking are being shaped by two major conclusions of this study: (1) there is a strong requirement for and it is feasible to achieve important and significant research in a zero-gravity cloud physics facility; and (2) some very important experiments can be accomplished with 'off-the-shelf' type hardware by astronauts who have no cloud-physics background; the most complicated experiments may require sophisticated observation and motion subsystems and the astronaut may need graduate level cloud physics training; there is a large number of experiments whose complexity varies between these two extremes.

Speech information retrieval: a review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hafen, Ryan P.; Henry, Michael J.

Audio is an information-rich component of multimedia. Information can be extracted from audio in a number of different ways, and thus there are several established audio signal analysis research fields. These fields include speech recognition, speaker recognition, audio segmentation and classification, and audio finger-printing. The information that can be extracted from tools and methods developed in these fields can greatly enhance multimedia systems. In this paper, we present the current state of research in each of the major audio analysis fields. The goal is to introduce enough back-ground for someone new in the field to quickly gain high-level understanding andmore » to provide direction for further study.« less

A grounded theory study on the academic success of undergraduate women in science, engineering, and mathematics fields at a private, research university

NASA Astrophysics Data System (ADS)

Hroch, Amber Michelle

2011-12-01

This grounded theory study revealed the common factors of backgrounds, strategies, and motivators in academically successful undergraduate women in science, engineering, and mathematics (SEM) fields at a private, research university in the West. Data from interviews with 15 women with 3.25 or better grade point averages indicated that current academic achievement in their college SEM fields can be attributed to previous academic success, self awareness, time management and organizational skills, and maintaining a strong support network. Participants were motivated by an internal drive to academically succeed and attend graduate school. Recommendations are provided for professors, advisors, and student affairs professionals.

Identification of pathogen genomic variants through an integrated pipeline

PubMed Central

2014-01-01

Background Whole-genome sequencing represents a powerful experimental tool for pathogen research. We present methods for the analysis of small eukaryotic genomes, including a streamlined system (called Platypus) for finding single nucleotide and copy number variants as well as recombination events. Results We have validated our pipeline using four sets of Plasmodium falciparum drug resistant data containing 26 clones from 3D7 and Dd2 background strains, identifying an average of 11 single nucleotide variants per clone. We also identify 8 copy number variants with contributions to resistance, and report for the first time that all analyzed amplification events are in tandem. Conclusions The Platypus pipeline provides malaria researchers with a powerful tool to analyze short read sequencing data. It provides an accurate way to detect SNVs using known software packages, and a novel methodology for detection of CNVs, though it does not currently support detection of small indels. We have validated that the pipeline detects known SNVs in a variety of samples while filtering out spurious data. We bundle the methods into a freely available package. PMID:24589256

Interdisciplinary Research Career Development: Building Interdisciplinary Research Careers in Women's Health Program Best Practices

PubMed Central

Bodurtha, Joann; Nagel, Joan D.

2011-01-01

Abstract Background The Office of Research on Women's Health (ORWH) and the National Institutes of Health (NIH) Institutes and Centers and the Agency for Health Care Research and Quality (AHRQ) have sponsored an interdisciplinary research career development program in five funding cycles since 2000 through a K12 mechanism titled “Building Interdisciplinary Research Careers in Women's Health (BIRCWH).” As of 2010, 407 scholars have been supported in interdisciplinary women's health research and a total of 63 BIRCWH program awards have been made to 41 institutions across the U.S. Methods In an effort to share practical approaches to interdisciplinary research training, currently funded BIRCWH sites were invited to submit 300-word bullet-point style summaries describing their best practices in interdisciplinary research training following a common format with an emphasis on practices that are innovative, can be reproduced in other places, and advance women's health research. Results and Conclusions Twenty-six program narratives provide unique perspectives along with common elements and themes in interdisciplinary research training best practices. PMID:21923414

Status and Growth of Underground Science at WIPP

NASA Astrophysics Data System (ADS)

Rempe, Norbert T.

2008-10-01

The science community is increasingly taking advantage of research opportunities in the government-owned Waste Isolation Pilot Plant (WIPP), 655m underground near Carlsbad, NM. Discoveries so far include viable bacteria, cellulose, and DNA in 250 million-year old salt, preserved in an ultra-low background-radiation setting. Supplementing the overburden's shielding against cosmic radiation, terrestrial background from the host formation is less than five percent that of average crustal rock. In the past, WIPP accommodated development and testing of neutral current detectors for the Sudbury Neutrino Observatory and dark matter research, and it currently hosts two experiments pursuing neutrino-less double-beta decay. That scientists can listen to whispers from the universe in proximity to megacuries of radioactive waste lends, of course, credibility to the argument that WIPP itself is very safe. Almost a century of regional petroleum and potash extraction history and more than three decades of WIPP studies have generated a comprehensive body of knowledge on geology, mining technology, rock mechanics, geochemistry, and other disciplines relevant to underground science. Existing infrastructure is being used and can be expanded to fit experimental needs. WIPP's exemplary safety and regulatory compliance culture, low excavating and operating cost, and the high probability of the repository operating at least another 40 years make its available underground space attractive for future research and development. Recent proposals include low-photon energy counting to study internal dose received decades ago, investigations into ultra-low radiation dose response in cell cultures and laboratory animals (e.g., hormesis vs. linear no-threshold) and detectors for dark matter, solar and supernova neutrinos, and proton decay. Additional proposals compatible with WIPP's primary mission are welcome.

Saudi views on consenting for research on medical records and leftover tissue samples

PubMed Central

2010-01-01

Background Consenting for retrospective medical records-based research (MR) and leftover tissue-based research (TR) continues to be controversial. Our objective was to survey Saudis attending outpatient clinics at a tertiary care hospital on their personal preference and perceptions of norm and current practice in relation to consenting for MR and TR. Methods We surveyed 528 Saudis attending clinics at a tertiary care hospital in Saudi Arabia to explore their preferences and perceptions of norm and current practice. The respondents selected one of 7 options from each of 6 questionnaires. Results Respondents' mean (SD) age was 33 (11) years, 42% were males, 56% were patients, 84% had ≥ secondary school education, and 10% had previously volunteered for research. Respectively, 40% and 49% perceived that the norm is to conduct MR and TR without consent and 38% and 37% with general or proposal-specific consent; the rest objected to such research. There was significant difference in the distribution of choices according to health status (patients vs. companions) for MR (adjusted Kruskal-Wallis test P = 0.03) but not to age group, gender, education level, or previous participation in research (unadjusted P = 0.02 - 0.59). The distributions of perceptions of current practice and norm were similar (unadjusted Marginal Homogeneity test P = 0.44 for MR and P = 0.89 for TR), whereas the distributions of preferences and perceptions of norm were different (adjusted P = 0.09 for MR and P = 0.02 for TR). The distributions of perceptions of norm, preferences, and perceptions of current practice for MR were significantly different from those of TR (adjusted P < 0.009 for all). Conclusions We conclude that: 1) there is a considerable diversity among Saudi views regarding consenting for retrospective research which may be related to health status, 2) the distribution of perceptions of norm was similar to the distribution of perceptions of current practice but different from that of preferences, and 3) MR and TR are perceived differently in regard to consenting. PMID:20955580

[Study on the method for the determination of trace boron, molybdenum, silver, tin and lead in geochemical samples by direct current arc full spectrum direct reading atomic emission spectroscopy (DC-Arc-AES)].

PubMed

Hao, Zhi-hong; Yao, Jian-zhen; Tang, Rui-ling; Zhang, Xue-mei; Li, Wen-ge; Zhang, Qin

2015-02-01

The method for the determmation of trace boron, molybdenum, silver, tin and lead in geochemical samples by direct current are full spectrum direct reading atomic emission spectroscopy (DC-Arc-AES) was established. Direct current are full spectrum direct reading atomic emission spectrometer with a large area of solid-state detectors has functions of full spectrum direct reading and real-time background correction. The new electrodes and new buffer recipe were proposed in this paper, and have applied for national patent. Suitable analytical line pairs, back ground correcting points of elements and the internal standard method were selected, and Ge was used as internal standard. Multistage currents were selected in the research on current program, and each current set different holding time to ensure that each element has a good signal to noise ratio. Continuous rising current mode selected can effectively eliminate the splash of the sample. Argon as shielding gas can eliminate CN band generating and reduce spectral background, also plays a role in stabilizing the are, and argon flow 3.5 L x min(-1) was selected. Evaporation curve of each element was made, and it was concluded that the evaporation behavior of each element is consistent, and combined with the effects of different spectrographic times on the intensity and background, the spectrographic time of 35s was selected. In this paper, national standards substances were selected as a standard series, and the standard series includes different nature and different content of standard substances which meet the determination of trace boron, molybdenum, silver, tin and lead in geochemical samples. In the optimum experimental conditions, the detection limits for B, Mo, Ag, Sn and Pb are 1.1, 0.09, 0.01, 0.41, and 0.56 microg x g(-1) respectively, and the precisions (RSD, n=12) for B, Mo, Ag, Sn and Pb are 4.57%-7.63%, 5.14%-7.75%, 5.48%-12.30%, 3.97%-10.46%, and 4.26%-9.21% respectively. The analytical accuracy was validated by national standards and the results are in agreement with certified values. The method is simple, rapid, is an advanced analytical method for the determination of trace amounts of geochemical samples' boron, molybdenum, silver, tin and lead, and has a certain practicality.

Background review for diagnostic test development for Zika virus infection.

PubMed

Charrel, Rémi N; Leparc-Goffart, Isabelle; Pas, Suzan; de Lamballerie, Xavier; Koopmans, Marion; Reusken, Chantal

2016-08-01

To review the state of knowledge about diagnostic testing for Zika virus infection and identify areas of research needed to address the current gaps in knowledge. We made a non-systematic review of the published literature about Zika virus and supplemented this with information from commercial diagnostic test kits and personal communications with researchers in European preparedness networks. The review covered current knowledge about the geographical spread, pathogen characteristics, life cycle and infection kinetics of the virus. The available molecular and serological tests and biosafety issues are described and discussed in the context of the current outbreak strain. We identified the following areas of research to address current knowledge gaps: (i) an urgent assessment of the laboratory capacity and capability of countries to detect Zika virus; (ii) rapid and extensive field validation of the available molecular and serological tests in areas with and without Zika virus transmission, with a focus on pregnant women; (iii) monitoring the genomic diversity of circulating Zika virus strains; (iv) prospective studies into the virus infection kinetics, focusing on diagnostic sampling (specimen types, combinations and timings); and (v) developing external quality assessments for molecular and serological testing, including differential diagnosis for similar viruses and symptom clusters. The availability of reagents for diagnostic development (virus strains and antigens, quantified viral ribonucleic acid) needs to be facilitated. An international laboratory response is needed, including preparation of protocols for prospective studies to address the most pressing information needs.

Background review for diagnostic test development for Zika virus infection

PubMed Central

Charrel, Rémi N; Leparc-Goffart, Isabelle; Pas, Suzan; de Lamballerie, Xavier; Koopmans, Marion; Reusken, Chantal

2016-01-01

Abstract Objective To review the state of knowledge about diagnostic testing for Zika virus infection and identify areas of research needed to address the current gaps in knowledge. Methods We made a non-systematic review of the published literature about Zika virus and supplemented this with information from commercial diagnostic test kits and personal communications with researchers in European preparedness networks. The review covered current knowledge about the geographical spread, pathogen characteristics, life cycle and infection kinetics of the virus. The available molecular and serological tests and biosafety issues are described and discussed in the context of the current outbreak strain. Findings We identified the following areas of research to address current knowledge gaps: (i) an urgent assessment of the laboratory capacity and capability of countries to detect Zika virus; (ii) rapid and extensive field validation of the available molecular and serological tests in areas with and without Zika virus transmission, with a focus on pregnant women; (iii) monitoring the genomic diversity of circulating Zika virus strains; (iv) prospective studies into the virus infection kinetics, focusing on diagnostic sampling (specimen types, combinations and timings); and (v) developing external quality assessments for molecular and serological testing, including differential diagnosis for similar viruses and symptom clusters. The availability of reagents for diagnostic development (virus strains and antigens, quantified viral ribonucleic acid) needs to be facilitated. Conclusion An international laboratory response is needed, including preparation of protocols for prospective studies to address the most pressing information needs. PMID:27516635

Effects of noise on speech recognition: Challenges for communication by service members.

PubMed

Le Prell, Colleen G; Clavier, Odile H

2017-06-01

Speech communication often takes place in noisy environments; this is an urgent issue for military personnel who must communicate in high-noise environments. The effects of noise on speech recognition vary significantly according to the sources of noise, the number and types of talkers, and the listener's hearing ability. In this review, speech communication is first described as it relates to current standards of hearing assessment for military and civilian populations. The next section categorizes types of noise (also called maskers) according to their temporal characteristics (steady or fluctuating) and perceptive effects (energetic or informational masking). Next, speech recognition difficulties experienced by listeners with hearing loss and by older listeners are summarized, and questions on the possible causes of speech-in-noise difficulty are discussed, including recent suggestions of "hidden hearing loss". The final section describes tests used by military and civilian researchers, audiologists, and hearing technicians to assess performance of an individual in recognizing speech in background noise, as well as metrics that predict performance based on a listener and background noise profile. This article provides readers with an overview of the challenges associated with speech communication in noisy backgrounds, as well as its assessment and potential impact on functional performance, and provides guidance for important new research directions relevant not only to military personnel, but also to employees who work in high noise environments. Copyright © 2016 Elsevier B.V. All rights reserved.

The Sanford Underground Research Facility at Homestake (SURF)

DOE PAGES

Lesko, K. T.

2015-03-24

The former Homestake gold mine in Lead, South Dakota is being transformed into a dedicated laboratory to pursue underground research in rare-process physics, as well as offering research opportunities in other disciplines. A key component of the Sanford Underground Research Facility (SURF) is the Davis Campus, which is in operation at the 4850-foot level (4300 m.w.e) and currently hosts three projects: the LUX dark matter experiment, the Majorana Demonstrator neutrinoless double-beta decay experiment and the Berkeley and CUBED low-background counters. Plans for possible future experiments at SURF are well underway and include long baseline neutrino oscillation experiments, future dark mattermore » experiments as well as nuclear astrophysics accelerators. Facility upgrades to accommodate some of these future projects have already started. SURF is a dedicated facility with significant expansion capability. These plans include a Generation-2 Dark Matter experiment and the US flagship neutrino experiment, LBNE.« less

[Biomedicine in thoracic surgery: state of the art].

PubMed

Leistner, M; Steinke, M; Walles, T

2013-06-01

Biomedicine represents a new scientific field at the interface of human, molecular and cell biology and medicine. Comprising the diverse disciplines of stem cell research, tissue engineering and material sciences, biomedicine gives rise to new approaches in research and therapy for - to date - unmet medical issues. Biomedical research is currently conducted in many medical, especially surgical subspecialties, and a number of successful developments have already been brought to clinical application. Concerning thoracic surgery, biomedical approaches are pursued primarily for tissue and organ replacement of the upper airways, lung and thoracic wall. In spite of a comparatively small research foundation, five different concepts have been clinically implemented worldwide, due to a lack of established treatment options in the case of extensive disease of the greater airways. In this review, the clinical background and the tissue-specific basics of tracheobronchial biomedicine are presented. Georg Thieme Verlag KG Stuttgart · New York.

Posttraumatic Stress Disorder, Cardiovascular and Metabolic Disease: A Review of the Evidence

PubMed Central

Dedert, Eric A.; Calhoun, Patrick S.; Watkins, Lana L.; Sherwood, Andrew; Beckham, Jean C.

2011-01-01

Background Posttraumatic stress disorder (PTSD) is a significant risk factor for cardiovascular and metabolic disease. Purpose The purpose of the current review is to evaluate the evidence suggesting that PTSD increases cardiovascular and metabolic risk factors, and to identify possible biomarkers and psychosocial characteristics and behavioral variables that are associated with these outcomes. Methods A systematic literature search in the period of 2002–2009 for PTSD, cardiovascular disease, and metabolic disease was conducted. Results The literature search yielded 78 studies on PTSD and cardiovascular/metabolic disease and biomarkers. Conclusions Although the available literature suggests an association of PTSD with cardiovascular disease and biomarkers, further research must consider potential confounds, incorporate longitudinal designs, and conduct careful PTSD assessments in diverse samples to address gaps in the research literature. Research on metabolic disease and biomarkers suggests an association with PTSD, but has not progressed as far as the cardiovascular research. PMID:20174903

Modifications to the 4x7 meter tunnel for acoustic research: Engineering feasibility study

NASA Technical Reports Server (NTRS)

1986-01-01

The NASA-Langley Research Center 4 x 7 Meter Low Speed Wind Tunnel is currently being used for low speed aerodynamics, V/STOL aerodynamics and, to a limited extent, rotorcraft noise research. The deficiencies of this wind tunnel for both aerodynamics and aeroacoustics research have been recognized for some time. Modifications to the wind tunnel are being made to improve the test section flow quality and to update the model cart systems. A further modification of the 4 x 7 Meter Wind Tunnel to permit rotorcraft model acoustics research has been proposed. As a precursor to the design of the proposed modifications, NASA is conducted both in-house and contracted studies to define the acoustic environment within the wind tunnel and to provide recommendations or the reduction of the wind tunnel background noise to a level acceptable to acoustics researchers. One of these studies by an acoustics consultant, has produced the primary reference documents that define the wind tunnel noise sources and outline recommended solutions.

Detrusor underactivity: Pathophysiological considerations, models and proposals for future research. ICI-RS 2013.

PubMed

van Koeveringe, Gommert A; Rademakers, Kevin L J; Birder, Lori A; Korstanje, Cees; Daneshgari, Firouz; Ruggieri, Michael R; Igawa, Yasuhiko; Fry, Christopher; Wagg, Adrian

2014-06-01

Detrusor underactivity, resulting in either prolonged or inefficient voiding, is a common clinical problem for which treatment options are currently limited. The aim of this report is to summarize current understanding of the clinical observation and its underlying pathophysiological entities. This report results from presentations and subsequent discussion at the International Consultation on Incontinence Research Society (ICI-RS) in Bristol, 2013. The recommendations made by the ICI-RS panel include: Development of study tools based on a system's pathophysiological approach, correlation of in vitro and in vivo data in experimental animals and humans, and development of more comprehensive translational animal models. In addition, there is a need for longitudinal patient data to define risk groups and for the development of screening tools. In the near-future these recommendations should lead to a better understanding of detrusor underactivity and its pathophysiological background. Neurourol. Urodynam. 33:591-596, 2014. © 2014 Wiley Periodicals, Inc. © 2014 Wiley Periodicals, Inc.

Challenges in conducting community-driven research created by differing ways of talking and thinking about science: a researcher's perspective.

PubMed

Colquhoun, Amy; Geary, Janis; Goodman, Karen J

2013-01-01

Increasingly, health scientists are becoming aware that research collaborations that include community partnerships can be an effective way to broaden the scope and enhance the impact of research aimed at improving public health. Such collaborations extend the reach of academic scientists by integrating a variety of perspectives and thus strengthening the applicability of the research. Communication challenges can arise, however, when attempting to address specific research questions in these collaborations. In particular, inconsistencies can exist between scientists and community members in the use and interpretation of words and other language features, particularly when conducting research with a biomedical component. Additional challenges arise from differing perceptions of the investigative process. There may be divergent perceptions about how research questions should and can be answered, and in expectations about requirements of research institutions and research timelines. From these differences, misunderstandings can occur about how the results will ultimately impact the community. These communication issues are particularly challenging when scientists and community members are from different ethnic and linguistic backgrounds that may widen the gap between ways of talking and thinking about science, further complicating the interactions and exchanges that are essential for effective joint research efforts. Community-driven research that aims to describe the burden of disease associated with Helicobacter pylori infection is currently underway in northern Aboriginal communities located in the Yukon and Northwest Territories, Canada, with the goal of identifying effective public health strategies for reducing health risks from this infection. This research links community representatives, faculty from various disciplines at the University of Alberta, as well as territorial health care practitioners and officials. This highly collaborative work will be used to illustrate, from a researcher's perspective, some of the challenges of conducting public health research in teams comprising members with varying backgrounds. The consequences of these challenges will be outlined, and potential solutions will be offered.

Identifying management competencies for health care executives: review of a series of Delphi studies.

PubMed

Hudak, R P; Brooke, P P; Finstuen, K

2000-01-01

This analysis reviews a selected body of research that identifies the essential areas of management expertise required of future health care executives. To ensure consistency, six studies are analyzed, utilizing the Delphi technique, to query a broad spectrum of experts in different fields and sites of health care management. The analysis identifies a number of management competencies, i.e., managerial capabilities, which current and aspiring health care executives, in various settings and with differing educational backgrounds, should possess to enhance the probability of their success in current and future positions of responsibility. In addition, this review identifies the skills (technical expertise), knowledge (facts and principles) and abilities (physical, mental or legal power) required to support achievement of these competencies. Leadership and resource management, including cost and finance dimensions, are the highest-rated requisite management competencies. The dominant skills, knowledge and abilities (SKAs) are related to interpersonal skills. The lowest-rated SKAs are related to job-specific, technical skills. Recommendations include the review of this research by formal and continuing education programs to determine the content of their courses and areas for future research. Similarly, current health care executives should assess this research to assist in identifying competency gaps. Lastly, this analysis recommends that the Delphi technique, as a valid and replicable methodology, be applied toward the study of non-executive health care managers, e.g., students, clinicians, mid-level managers and integrated systems administrators, to determine their requisite management competencies and SKAs.

Addressing Prediabetes in Childhood Obesity Treatment Programs: Support from Research and Current Practice

PubMed Central

Grow, H. Mollie; Fernandez, Cristina; Lukasiewicz, Gloria J.; Rhodes, Erinn T.; Shaffer, Laura A.; Sweeney, Brooke; Woolford, Susan J.; Estrada, Elizabeth

2014-01-01

Abstract Background: Type 2 diabetes mellitus (T2DM) and prediabetes have increased in prevalence among overweight and obese children, with significant implications for long-term health. There is little published evidence on the best approaches to care of prediabetes among overweight youth or the current practices used across pediatric weight management programs. Methods: This article reviews the literature and summarizes current practices for screening, diagnosis, and treatment of prediabetes at childhood obesity treatment centers. Findings regarding current practice were based on responses to an online survey from 28 pediatric weight management programs at 25 children's hospitals in 2012. Based on the literature reviewed, and empiric data, consensus support statements on prediabetes care and T2DM prevention were developed among representatives of these 25 children's hospitals' obesity clinics. Results: The evidence reviewed demonstrates that current T2DM and prediabetes diagnostic parameters are derived from adult-based studies with little understanding of clinical outcomes among youth. Very limited evidence exists on preventing progression of prediabetes. Some evidence suggests that a significant proportion of obese youth with prediabetes will revert to normoglycemia without pharmacological management. Evidence supports lifestyle modification for children with prediabetes, but further study of specific lifestyle changes and pharmacological treatments is needed. Conclusion: Evidence to guide management of prediabetes in children is limited. Current practice patterns of pediatric weight management programs show areas of variability in practice, reflecting the limited evidence base. More research is needed to guide clinical care for overweight youth with prediabetes. PMID:25055134

The LUX-Zeplin Dark Matter Detector

NASA Astrophysics Data System (ADS)

Mock, Jeremy; Lux-Zeplin (Lz) Collaboration

2016-03-01

The LUX-ZEPLIN (LZ) detector is a second generation dark matter experiment that will operate at the 4850 foot level of the Sanford Underground Research Experiment as a follow-up to the LUX detector, currently the world's most sensitive WIMP direct detection experiment. The LZ detector will contain 7 tonnes of active liquid xenon with a 5.6 tonne fiducial mass in the TPC. The TPC is surrounded by an active, instrumented, liquid-xenon ``skin'' region to veto gammas, then a layer of liquid scintillator to veto neutrons, all contained within a water shield. Modeling the detector is key to understanding the expected background, which in turn leads to a better understanding of the projected sensitivity, currently expected to be 2e-48 cm2 for a 50 GeV WIMP. I will discuss the current status of the LZ experiment as well as its projected sensitivity.

Current and future risks of asbestos exposure in the Australian community

PubMed Central

2016-01-01

Background Australia mined asbestos for more than 100 years and manufactured and imported asbestos products. There is a legacy of in situ asbestos throughout the built environment. Methods The aim of this study was to identify the possible sources of current and future asbestos exposure from the built environment. Telephone interviews with environmental health officers, asbestos removalists, and asbestos assessors in Australia sought information about common asbestos scenarios encountered. Results There is a considerable amount of asbestos remaining in situ in the Australian built environment. Potential current and future sources of asbestos exposure to the public are from asbestos-containing roofs and fences, unsafe asbestos removal practices, do-it-yourself home renovations and illegal dumping. Conclusion This research has highlighted a need for consistent approaches in the regulation and enforcement of safe practices for the management and removal of asbestos to ensure that in situ asbestos in the built environment is managed appropriately. PMID:27611196

A Java application for tissue section image analysis.

PubMed

Kamalov, R; Guillaud, M; Haskins, D; Harrison, A; Kemp, R; Chiu, D; Follen, M; MacAulay, C

2005-02-01

The medical industry has taken advantage of Java and Java technologies over the past few years, in large part due to the language's platform-independence and object-oriented structure. As such, Java provides powerful and effective tools for developing tissue section analysis software. The background and execution of this development are discussed in this publication. Object-oriented structure allows for the creation of "Slide", "Unit", and "Cell" objects to simulate the corresponding real-world objects. Different functions may then be created to perform various tasks on these objects, thus facilitating the development of the software package as a whole. At the current time, substantial parts of the initially planned functionality have been implemented. Getafics 1.0 is fully operational and currently supports a variety of research projects; however, there are certain features of the software that currently introduce unnecessary complexity and inefficiency. In the future, we hope to include features that obviate these problems.

Transcranial Direct Current Stimulation (tDCS): A Promising Treatment for Major Depressive Disorder?

PubMed Central

Bennabi, Djamila; Haffen, Emmanuel

2018-01-01

Background: Transcranial direct current stimulation (tDCS) opens new perspectives in the treatment of major depressive disorder (MDD), because of its ability to modulate cortical excitability and induce long-lasting effects. The aim of this review is to summarize the current status of knowledge regarding tDCS application in MDD. Methods: In this review, we searched for articles published in PubMed/MEDLINE from the earliest available date to February 2018 that explored clinical and cognitive effects of tDCS in MDD. Results: Despite differences in design and stimulation parameters, the examined studies indicated beneficial effects of tDCS for MDD. These preliminary results, the non-invasiveness of tDCS, and its good tolerability support the need for further research on this technique. Conclusions: tDCS constitutes a promising therapeutic alternative for patients with MDD, but its place in the therapeutic armamentarium remains to be determined. PMID:29734768

Background, Structure and Priorities of the 2013 Geneva Declaration on Person-centered Health Research

PubMed Central

Salvador-Carulla, Luis; Cloninger, C Robert; Thornicroft, Amalia; Mezzich, Juan E.

2015-01-01

Declarations are relevant tools to frame new areas in health care, to raise awareness and to facilitate knowledge-to-action. The International College on Person Centered Medicine (ICPCM) is seeking to extend the impact of the ICPCM Conference Series by producing a declaration on every main topic. The aim of this paper is to describe the development of the 2013 Geneva Declaration on Person-centered Health Research and to provide additional information on the research priority areas identified during this iterative process. There is a need for more PCM research and for the incorporation of the PCM approach into general health research. Main areas of research focus include: Conceptual, terminological, and ontological issues; research to enhance the empirical evidence of PCM main components such as PCM informed clinical communication; PCM-based diagnostic models; person-centered care and interventions; and people-centered care, research on training and curriculum development. Dissemination and implementation of PCM knowledge-base is integral to Person-centered Health Research and shall engage currently available scientific and translational dissemination tools such journals, events and eHealth. PMID:26146541

A mixed-methods study on perceptions towards use of Rapid Ethical Assessment to improve informed consent processes for health research in a low-income setting

PubMed Central

2014-01-01

Background Rapid Ethical Assessment (REA) is a form of rapid ethnographic assessment conducted at the beginning of research project to guide the consent process with the objective of reconciling universal ethical guidance with specific research contexts. The current study is conducted to assess the perceived relevance of introducing REA as a mainstream tool in Ethiopia. Methods Mixed methods research using a sequential explanatory approach was conducted from July to September 2012, including 241 cross-sectional, self-administered and 19 qualitative, in-depth interviews among health researchers and regulators including ethics committee members in Ethiopian health research institutions and universities. Results In their evaluation of the consent process, only 40.2% thought that the consent process and information given were adequately understood by study participants; 84.6% claimed they were not satisfied with the current consent process and 85.5% thought the best interests of study participants were not adequately considered. Commonly mentioned consent-related problems included lack of clarity (48.1%), inadequate information (34%), language barriers (28.2%), cultural differences (27.4%), undue expectations (26.6%) and power imbalances (20.7%). About 95.4% believed that consent should be contextualized to the study setting and 39.4% thought REA would be an appropriate approach to improve the perceived problems. Qualitative findings helped to further explore the gaps identified in the quantitative findings and to map-out concerns related to the current research consent process in Ethiopia. Suggestions included, conducting REA during the pre-test (pilot) phase of studies when applicable. The need for clear guidance for researchers on issues such as when and how to apply the REA tools was stressed. Conclusion The study findings clearly indicated that there are perceived to be correctable gaps in the consent process of medical research in Ethiopia. REA is considered relevant by researchers and stakeholders to address these gaps. Exploring further the feasibility and applicability of REA is recommended. PMID:24885049

High sensitivity of spontaneous spike frequency to sodium leak current in a Lymnaea pacemaker neuron.

PubMed

Lu, T Z; Kostelecki, W; Sun, C L F; Dong, N; Pérez Velázquez, J L; Feng, Z-P

2016-12-01

The spontaneous rhythmic firing of action potentials in pacemaker neurons depends on the biophysical properties of voltage-gated ion channels and background leak currents. The background leak current includes a large K + and a small Na + component. We previously reported that a Na + -leak current via U-type channels is required to generate spontaneous action potential firing in the identified respiratory pacemaker neuron, RPeD1, in the freshwater pond snail Lymnaea stagnalis. We further investigated the functional significance of the background Na + current in rhythmic spiking of RPeD1 neurons. Whole-cell patch-clamp recording and computational modeling approaches were carried out in isolated RPeD1 neurons. The whole-cell current of the major ion channel components in RPeD1 neurons were characterized, and a conductance-based computational model of the rhythmic pacemaker activity was simulated with the experimental measurements. We found that the spiking rate is more sensitive to changes in the Na + leak current as compared to the K + leak current, suggesting a robust function of Na + leak current in regulating spontaneous neuronal firing activity. Our study provides new insight into our current understanding of the role of Na + leak current in intrinsic properties of pacemaker neurons. © 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

Assessing scientists for hiring, promotion, and tenure.

PubMed

Moher, David; Naudet, Florian; Cristea, Ioana A; Miedema, Frank; Ioannidis, John P A; Goodman, Steven N

2018-03-01

Assessment of researchers is necessary for decisions of hiring, promotion, and tenure. A burgeoning number of scientific leaders believe the current system of faculty incentives and rewards is misaligned with the needs of society and disconnected from the evidence about the causes of the reproducibility crisis and suboptimal quality of the scientific publication record. To address this issue, particularly for the clinical and life sciences, we convened a 22-member expert panel workshop in Washington, DC, in January 2017. Twenty-two academic leaders, funders, and scientists participated in the meeting. As background for the meeting, we completed a selective literature review of 22 key documents critiquing the current incentive system. From each document, we extracted how the authors perceived the problems of assessing science and scientists, the unintended consequences of maintaining the status quo for assessing scientists, and details of their proposed solutions. The resulting table was used as a seed for participant discussion. This resulted in six principles for assessing scientists and associated research and policy implications. We hope the content of this paper will serve as a basis for establishing best practices and redesigning the current approaches to assessing scientists by the many players involved in that process.

A comparison of traditional anti-inflammation and anti-infection medicinal plants with current evidence from biomedical research: Results from a regional study

PubMed Central

Vieira, A.

2010-01-01

Background: In relation to pharmacognosy, an objective of many ethnobotanical studies is to identify plant species to be further investigated, for example, tested in disease models related to the ethnomedicinal application. To further warrant such testing, research evidence for medicinal applications of these plants (or of their major phytochemical constituents and metabolic derivatives) is typically analyzed in biomedical databases. Methods: As a model of this process, the current report presents novel information regarding traditional anti-inflammation and anti-infection medicinal plant use. This information was obtained from an interview-based ethnobotanical study; and was compared with current biomedical evidence using the Medline® database. Results: Of the 8 anti-infection plant species identified in the ethnobotanical study, 7 have related activities reported in the database; and of the 6 anti-inflammation plants, 4 have related activities in the database. Conclusion: Based on novel and complimentary results from the ethnobotanical and biomedical database analyses, it is suggested that some of these plants warrant additional investigation of potential anti-inflammatory or anti-infection activities in related disease models, and also additional studies in other population groups. PMID:21589754

Assessing scientists for hiring, promotion, and tenure

PubMed Central

Naudet, Florian; Cristea, Ioana A.; Miedema, Frank; Ioannidis, John P. A.; Goodman, Steven N.

2018-01-01

Assessment of researchers is necessary for decisions of hiring, promotion, and tenure. A burgeoning number of scientific leaders believe the current system of faculty incentives and rewards is misaligned with the needs of society and disconnected from the evidence about the causes of the reproducibility crisis and suboptimal quality of the scientific publication record. To address this issue, particularly for the clinical and life sciences, we convened a 22-member expert panel workshop in Washington, DC, in January 2017. Twenty-two academic leaders, funders, and scientists participated in the meeting. As background for the meeting, we completed a selective literature review of 22 key documents critiquing the current incentive system. From each document, we extracted how the authors perceived the problems of assessing science and scientists, the unintended consequences of maintaining the status quo for assessing scientists, and details of their proposed solutions. The resulting table was used as a seed for participant discussion. This resulted in six principles for assessing scientists and associated research and policy implications. We hope the content of this paper will serve as a basis for establishing best practices and redesigning the current approaches to assessing scientists by the many players involved in that process. PMID:29596415

Pentaploid Wheat Hybrids: Applications, Characterisation, and Challenges

PubMed Central

Padmanaban, Sriram; Zhang, Peng; Hare, Ray A.; Sutherland, Mark W.; Martin, Anke

2017-01-01

Interspecific hybridisation between hexaploid and tetraploid wheat species leads to the development of F1 pentaploid hybrids with unique chromosomal constitutions. Pentaploid hybrids derived from bread wheat (Triticum aestivum L.) and durum wheat (Triticum turgidum spp. durum Desf.) crosses can improve the genetic background of either parent by transferring traits of interest. The genetic variability derived from bread and durum wheat and transferred into pentaploid hybrids has the potential to improve disease resistance, abiotic tolerance, and grain quality, and to enhance agronomic characters. Nonetheless, pentaploid wheat hybrids have not been fully exploited in breeding programs aimed at improving crops. There are several potential barriers for efficient pentaploid wheat production, such as low pollen compatibility, poor seed set, failed seedling establishment, and frequent sterility in F1 hybrids. However, most of the barriers can be overcome by careful selection of the parental genotypes and by employing the higher ploidy level genotype as the maternal parent. In this review, we summarize the current research on pentaploid wheat hybrids and analyze the advantages and pitfalls of current methods used to assess pentaploid-derived lines. Furthermore, we discuss current and potential applications in commercial breeding programs and future directions for research into pentaploid wheat. PMID:28367153

Osteotomy models - the current status on pain scoring and management in small rodents.

PubMed

Lang, Annemarie; Schulz, Anja; Ellinghaus, Agnes; Schmidt-Bleek, Katharina

2016-12-01

Fracture healing is a complex regeneration process which produces new bone tissue without scar formation. However, fracture healing disorders occur in approximately 10% of human patients and cause severe pain and reduced quality of life. Recently, the development of more standardized, sophisticated and commercially available osteosynthesis techniques reflecting clinical approaches has increased the use of small rodents such as rats and mice in bone healing research dramatically. Nevertheless, there is no standard for pain assessment, especially in these species, and consequently limited information regarding the welfare aspects of osteotomy models. Moreover, the selection of analgesics is restricted for osteotomy models since non-steroidal anti-inflammatory drugs (NSAIDs) are known to affect the initial, inflammatory phase of bone healing. Therefore, opioids such as buprenorphine and tramadol are often used. However, dosage data in the literature are varied. Within this review, we clarify the background of osteotomy models, explain the current status and challenges of animal welfare assessment, and provide an example score sheet including model specific parameters. Furthermore, we summarize current refinement options and present a brief outlook on further 3R research. © The Author(s) 2016.

Gender differences amongst adult arsonists at psychiatric assessment.

PubMed

Dickens, Geoff; Sugarman, Philip; Ahmad, Farooq; Edgar, Simon; Hofberg, Kristina; Tewari, Sidharta

2007-07-01

Reports of gender differences amongst arsonists at psychiatric assessment are not uncommon, however some are based on relatively small samples. A new retrospective study highlighting gender differences could help to confirm or refute the current state of knowledge. The aim of the current study was to examine gender differences amongst a sample of 167 adult arsonists (129 males and 38 females). Information was collected from clinical records on sociodemographic, family background and childhood factors; adult adjustment; fire setting history; motives; features of pyromania and other offending, from the case notes of a group of arsonists referred to the West Midlands Psychiatry Service over a 24-year period. Female arsonists were older than males and more likely to have a psychiatric diagnosis. Women more frequently had a history of sexual abuse, while men had a more varied criminal background and more substance abuse problems. Our findings largely support previous research, and are discussed in this context, whilst also bringing attention to a more recently developed theory (Action System Model). Significant gender differences amongst arsonists indicates that different emphases in the treatment of male and female arsonists may be advisable, though a reliable evidence base for treatment has yet to be established.

Conservation status of freshwater gastropods of Canada and the United States

USGS Publications Warehouse

Johnson, Paul D.; Bogan, Arthur E.; Brown, Kenneth M.; Burkhead, Noel M.; Cordeiro, James R.; Garner, Jeffrey T.; Hartfield, Paul D.; Lepitzki, Dwayne A.; Mackie, Gerry L.; Pip, Eva; Tarpley, Thomas A.; Tiemann, Jeremy S.; Whelan, Nathan V.; Strong, Ellen E.

2013-01-01

This is the first American Fisheries Society conservation assessment of freshwater gastropods (snails) from Canada and the United States by the Gastropod Subcommittee (Endangered Species Committee). This review covers 703 species representing 16 families and 93 genera, of which 67 species are considered extinct, or possibly extinct, 278 are endangered, 102 are threatened, 73 are vulnerable, 157 are currently stable, and 26 species have uncertain taxonomic status. Of the entire fauna, 74% of gastropods are imperiled (vulnerable, threatened, endangered) or extinct, which exceeds imperilment levels in fishes (39%) and crayfishes (48%) but is similar to that of mussels (72%). Comparison of modern to background extinction rates reveals that gastropods have the highest modern extinction rate yet observed, 9,539 times greater than background rates. Gastropods are highly susceptible to habitat loss and degradation, particularly narrow endemics restricted to a single spring or short stream reaches. Compilation of this review was hampered by a paucity of current distributional information and taxonomic uncertainties. Although research on several fronts including basic biology, physiology, conservation strategies, life history, and ecology are needed, systematics and curation of museum collections and databases coupled with comprehensive status surveys (geographic limits, threat identification) are priorities.

Patient-centred care in general dental practice - a systematic review of the literature

PubMed Central

2014-01-01

Background Delivering improvements in quality is a key objective within most healthcare systems, and a view which has been widely embraced within the NHS in the United Kingdom. Within the NHS, quality is evaluated across three key dimensions: clinical effectiveness, safety and patient experience, with the latter modelled on the Picker Principles of Patient-Centred Care (PCC). Quality improvement is an important feature of the current dental contract reforms in England, with “patient experience” likely to have a central role in the evaluation of quality. An understanding and appreciation of the evidence underpinning PCC within dentistry is highly relevant if we are to use this as a measure of quality in general dental practice. Methods A systematic review of the literature was undertaken to identify the features of PCC relevant to dentistry and ascertain the current research evidence base underpinning its use as a measure of quality within general dental practice. Results Three papers were identified which met the inclusion criteria and demonstrated the use of primary research to provide an understanding of the key features of PCC within dentistry. None of the papers identified were based in general dental practice and none of the three studies sought the views of patients. Some distinct differences were noted between the key features of PCC reported within the dental literature and those developed within the NHS Patient Experience Framework. Conclusions This systematic review reveals a lack of understanding of PCC within dentistry, and in particular general dental practice. There is currently a poor evidence base to support the use of the current patient reported outcome measures as indicators of patient-centredness. Further research is necessary to understand the important features of PCC in dentistry and patients’ views should be central to this research. PMID:24902842

A Chinese young adult non-scientist's epistemologies and her understandings of the concept of speed

NASA Astrophysics Data System (ADS)

Cao, Ying; Brizuela, Barbara M.

2015-08-01

Past research has investigated students' epistemologies while they were taking courses that required an integrated understanding of mathematical and scientific concepts. However, past studies have not investigated students who are not currently enrolled in such classes. Additionally, past studies have primarily focused on individuals who are native English speakers from Western cultures. In this paper, we aim to investigate whether Hammer and his colleagues' claims concerning learners' epistemologies could be extended to individuals who lack advanced mathematics and science training, have had different cultural and learning experiences, and have grown up speaking and learning in another language. To this end, we interviewed a participant with these characteristics about her understandings of the concept of speed. Our findings show that previous theoretical frameworks can be used to explain the epistemologies of the individual examined in this study. The case suggests that these theories may be relevant regardless of the learner's mathematics and science background, language, educational experience, and cultural background. In the future, more cases should be examined with learners from different academic backgrounds and cultures to further support this finding.

The Effects of a Warm or Chilly Climate Toward Socioeconomic Diversity on Academic Motivation and Self-Concept.

PubMed

Browman, Alexander S; Destin, Mesmin

2016-02-01

Persistent academic achievement gaps exist between university students from high and low socioeconomic status (SES) backgrounds. The current research proposes that the extent to which a university is perceived as actively supporting versus passively neglecting students from diverse socioeconomic backgrounds can influence low-SES students' academic motivation and self-concepts. In Experiments 1 and 2, low-SES students exposed to cues suggestive of an institution's warmth toward socioeconomic diversity demonstrated greater academic efficacy, expectations, and implicit associations with high academic achievement compared with those exposed to cues indicating institutional chilliness. Exploring the phenomenology underlying these effects, Experiment 3 demonstrated that warmth cues led low-SES students to perceive their socioeconomic background as a better match with the rest of the student body and to perceive the university as more socioeconomically diverse than did chilliness cues. Contributions to our understanding of low-SES students' psychological experiences in academic settings and practical implications for academic institutions are discussed. © 2015 by the Society for Personality and Social Psychology, Inc.

Detector and readout performance goals for quantum well and strained layer superlattice focal plane arrays imaging under tactical and strategic backgrounds

NASA Astrophysics Data System (ADS)

Bandara, Sumith V.

2009-11-01

Advancements in III-V semiconductor based, Quantum-well infrared photodetector (QWIP) and Type-II Strained-Layer Superlattice detector (T2SLS) technologies have yielded highly uniform, large-format long-wavelength infrared (LWIR) QWIP FPAs and high quantum efficiency (QE), small format, LWIR T2SLS FPAs. In this article, we have analyzed the QWIP and T2SLS detector level performance requirements and readout integrated circuit (ROIC) noise levels for several staring array long-wavelength infrared (LWIR) imaging applications at various background levels. As a result of lower absorption QE and less than unity photoconductive gain, QWIP FPAs are appropriate for high background tactical applications. However, if the application restricts the integration time, QWIP FPA performance may be limited by the read noise of the ROIC. Rapid progress in T2SLS detector material has already demonstrated LWIR detectors with sufficient performance for tactical applications and potential for strategic applications. However, significant research is needed to suppress surface leakage currents in order to reproduce performances at pixel levels of T2SLS FPAs.

The Impact of Laughter Yoga on the Stress of Cancer Patients before Chemotherapy

PubMed Central

Farifteh, Shadi; Mohammadi-Aria, Alireza; Kiamanesh, Alireza; Mofid, Bahram

2014-01-01

Background Cancer is usually accompanied by considerable stress for the sufferer, and the stress has destructive effects on Chemotherapy treatment process. Therefore, the current research deals with the effect of yoga laughter on the cancer patients’ stress before chemotherapy. Methods In this research, as the first step, 37 cancer sufferers , who had been hospitalized in Shohada Tajrish Hospital (Behnam Daneshpoor Charity Organization) and had the requirements necessary for being taken as research samples, were selected for data collection. The mentioned patients were classified randomly in experimental and control groups. Collected data were analyzed by the multi-variable covariance analysis test. Results The results show there is a meaningful difference in the stress average before and after interference in the test group (p<0.05). Conclusion Laughter yoga can decrease the stress in cancer sufferers before chemotherapy. PMID:25628838

Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy.

PubMed

Wheatley, Lisa M; Plaut, Marshall; Schwaninger, Julie M; Banerji, Aleena; Castells, Mariana; Finkelman, Fred D; Gleich, Gerald J; Guttman-Yassky, Emma; Mallal, Simon A K; Naisbitt, Dean J; Ostrov, David A; Phillips, Elizabeth J; Pichler, Werner J; Platts-Mills, Thomas A E; Roujeau, Jean-Claude; Schwartz, Lawrence B; Trepanier, Lauren A

2015-08-01

Allergic reactions to drugs are a serious public health concern. In 2013, the Division of Allergy, Immunology, and Transplantation of the National Institute of Allergy and Infectious Diseases sponsored a workshop on drug allergy. International experts in the field of drug allergy with backgrounds in allergy, immunology, infectious diseases, dermatology, clinical pharmacology, and pharmacogenomics discussed the current state of drug allergy research. These experts were joined by representatives from several National Institutes of Health institutes and the US Food and Drug Administration. The participants identified important advances that make new research directions feasible and made suggestions for research priorities and for development of infrastructure to advance our knowledge of the mechanisms, diagnosis, management, and prevention of drug allergy. The workshop summary and recommendations are presented herein. Published by Elsevier Inc.

Efficacy of Selected Electrical Therapies on Chronic Low Back Pain: A Comparative Clinical Pilot Study.

PubMed

Rajfur, Joanna; Pasternok, Małgorzata; Rajfur, Katarzyna; Walewicz, Karolina; Fras, Beata; Bolach, Bartosz; Dymarek, Robert; Rosinczuk, Joanna; Halski, Tomasz; Taradaj, Jakub

2017-01-07

BACKGROUND In the currently available research publications on electrical therapy of low back pain, generally no control groups or detailed randomization were used, and such studies were often conducted with relatively small groups of patients, based solely on subjective questionnaires and pain assessment scales (lacking measurement methods to objectify the therapeutic progress). The available literature also lacks a comprehensive and large-scale clinical study. The purpose of this study was to assess the effects of treating low back pain using selected electrotherapy methods. The study assesses the influence of individual electrotherapeutic treatments on reduction of pain, improvement of the range of movement in lower section of the spine, and improvement of motor functions and mobility. MATERIAL AND METHODS The 127 patients qualified for the therapy (ultimately, 123 patients completed the study) and assigned to 6 comparison groups: A - conventional TENS, B - acupuncture-like TENS, C - high-voltage electrical stimulation, D - interferential current stimulation, E - diadynamic current, and F - control group. RESULTS The research showed that using electrical stimulation with interferential current penetrating deeper into the tissues results in a significant and more efficient elimination of pain, and an improvement of functional ability of patients suffering from low back pain on the basis of an analysis of both subjective and objective parameters. The TENS currents and high voltage were helpful, but not as effective. The use of diadynamic currents appears to be useless. CONCLUSIONS Selected electrical therapies (interferential current, TENS, and high voltage) appear to be effective in treating chronic low back pain.

Efficacy of Selected Electrical Therapies on Chronic Low Back Pain: A Comparative Clinical Pilot Study

PubMed Central

Rajfur, Joanna; Pasternok, Małgorzata; Rajfur, Katarzyna; Walewicz, Karolina; Fras, Beata; Bolach, Bartosz; Dymarek, Robert; Rosinczuk, Joanna; Halski, Tomasz; Taradaj, Jakub

2017-01-01

Background In the currently available research publications on electrical therapy of low back pain, generally no control groups or detailed randomization were used, and such studies were often conducted with relatively small groups of patients, based solely on subjective questionnaires and pain assessment scales (lacking measurement methods to objectify the therapeutic progress). The available literature also lacks a comprehensive and large-scale clinical study. The purpose of this study was to assess the effects of treating low back pain using selected electrotherapy methods. The study assesses the influence of individual electrotherapeutic treatments on reduction of pain, improvement of the range of movement in lower section of the spine, and improvement of motor functions and mobility. Material/Methods The 127 patients qualified for the therapy (ultimately, 123 patients completed the study) and assigned to 6 comparison groups: A – conventional TENS, B – acupuncture-like TENS, C – high-voltage electrical stimulation, D – interferential current stimulation, E – diadynamic current, and F – control group. Results The research showed that using electrical stimulation with interferential current penetrating deeper into the tissues results in a significant and more efficient elimination of pain, and an improvement of functional ability of patients suffering from low back pain on the basis of an analysis of both subjective and objective parameters. The TENS currents and high voltage were helpful, but not as effective. The use of diadynamic currents appears to be useless. Conclusions Selected electrical therapies (interferential current, TENS, and high voltage) appear to be effective in treating chronic low back pain. PMID:28062862

Controversies about sugars consumption: state of the science.

PubMed

Rippe, James M; Marcos, Ascensión

2016-11-01

Few topics in nutrition generate more controversy and debate than the putative associations between added sugars and health. With this as background, a group of researchers in the area of sugars and health gathered at the European Nutrition Conference (FENS) in 2015 to discuss these controversies and provide evidence-based science. The purpose of the current article was to provide a brief summary of some of the highlights from each of the presenters and serve as an Introduction to the supplement which contains full articles based on their presentations.

State of the Art and Challenges of Radio Spectrum Monitoring in China

NASA Astrophysics Data System (ADS)

Lu, Q. N.; Yang, J. J.; Jin, Z. Y.; Chen, D. Z.; Huang, M.

2017-10-01

This paper provides an overview of radio spectrum monitoring in China. First, research background, the motivation is described and then train of thought, the prototype system, and the accomplishments are presented. Current radio spectrum monitoring systems are man-machine communication systems, which are unable to detect and process the radio interference automatically. In order to realize intelligent radio monitoring and spectrum management, we proposed an Internet of Things-based spectrum sensing approach using information system architecture and implemented a pilot program; then some very interesting results were obtained.

Atmospheric electricity at Durham: the scientific contributions and legacy of J. A. ("Skip") Chalmers (1904-1967)

NASA Astrophysics Data System (ADS)

Aplin, Karen L.

2018-03-01

John Alan Chalmers made major contributions to atmospheric electricity over almost 40 years spent at Durham University, UK. He is particularly remembered in the atmospheric science community for his accessible and insightful textbook, Atmospheric Electricity, and his work on corona currents, which are still regularly cited. He also supervised over 35 research students. This article discusses his background, scientific contributions, and significant legacy to modern atmospheric science within the context of a long and productive career spent at one of England's principal northern universities.

iPhone and iPad Use in Orthopedic Surgery

PubMed Central

Duncan, Scott F. M.; Hendawi, Tariq K.; Sperling, John; Kakinoki, Ryosuke; Hartsock, Landon

2015-01-01

Background Thousands of healthcare mobile applications (apps) are available, and physicians are increasingly recognizing that mobile technology can improve their workflow and allow them to practice medicine in a better and/or more efficient manner. Methods This article highlights apps compatible with the iPhone and iPad and their utility to the busy orthopedic surgeon. Results Currently available apps address every aspect of healthcare: patient management, reference, education, and research. Conclusion Key aspects of helpful apps include low cost (preferably free), a user-friendly interface, and simplicity. PMID:25829881

Current Status of the Polyamine Research Field

PubMed Central

Pegg, Anthony E.; Casero, Robert A.

2013-01-01

This chapter provides an overview of the polyamine field and introduces the 32 other chapters that make up this volume. These chapters provide a wide range of methods, advice, and background relevant to studies of the function of polyamines, the regulation of their content, their role in disease, and the therapeutic potential of drugs targeting polyamine content and function. The methodology provided in this new volume will enable laboratories already working in this area to expand their experimental techniques and facilitate the entry of additional workers into this rapidly expanding field. PMID:21318864

Health literacy: setting an international collaborative research agenda

PubMed Central

Protheroe, Joanne; Wallace, Lorraine S; Rowlands, Gillian; DeVoe, Jennifer E

2009-01-01

Background Health literacy is an increasingly important topic in both the policy and research agendas of many countries. During the recent 36th Annual Meeting of the North American Primary Care Research Group, the authors led an audio-taped 3-hour forum, "Studying Health Literacy: Developing an International Collaboration," where the current state of health literacy (HL) in the United States (US) and United Kingdom (UK) was presented and attendees were encouraged to debate a future research agenda. Discussion of Forum Themes The debate centred around three distinct themes, including: (1) refining HL definitions and conceptual models, (2) HL measurement and assessment tools, and (3) developing a collaborative international research agenda. The attendees agreed that future research should be theoretically grounded and conceptual models employed in studies should be explicit to allow for international comparisons to be drawn. Summary and Authors Reflections The importance of HL research and its possible contribution to health disparities is becoming increasingly recognised internationally. International collaborations and comparative studies could illuminate some of the possible determinants of disparities, and also possibly provide a vehicle to examine other research questions of interest. PMID:19589176

The match between institutional elderly care management research and management challenges - a systematic literature review

PubMed Central

2012-01-01

Background Elderly care practice and its management together with policy and research play a crucial role in responding to increasing challenges in institutional care for elderly people. Successful dialogue between these is necessary. The purpose of this systematic literature review is to compare how institutional elderly care management research meets the care challenges currently emphasized in international long-term care policy documents. Methods This paper was based on a systematic literature review. After screening 1971 abstracts using inclusion/exclusion criteria, 58 refereed articles published between 2000 and 2010 remained for analysis. The articles were analyzed using theory-based content analysis by comparing the results to the framework based on analysis of international long-term care management policy documents. Results The current challenges of long-term care management identified from policy documents were Integrated Care Management, Productivity Management, Quality Management, Workforce Management and ICT Management. The research on institutional elderly care management responded somewhat to the challenges mentioned in policy documents. However, some of the challenges were studied broadly and some were paid only minor attention. Further, only few studies focused on the core items of challenges addressed in policy documents. Conclusions Institutional care management research needs to focus more on challenges in integrated care, productivity, ICT and division of labor. Managers, researchers and policy-makers should assume more active collaborative roles in processes of research, policymaking and policy implementation. In addition managers’ and policymakers’ scientific literacy needs to be enhanced. PMID:23137416

US/German Collaboration in Salt Repository Research, Design and Operation - 13243

DOE Office of Scientific and Technical Information (OSTI.GOV)

Steininger, Walter; Hansen, Frank; Biurrun, Enrique

2013-07-01

Recent developments in the US and Germany [1-3] have precipitated renewed efforts in salt repository investigations and related studies. Both the German rock salt repository activities and the US waste management programs currently face challenges that may adversely affect their respective current and future state-of-the-art core capabilities in rock salt repository science and technology. The research agenda being pursued by our respective countries leverages collective efforts for the benefit of both programs. The topics addressed by the US/German salt repository collaborations align well with the findings and recommendations summarized in the January 2012 US Blue Ribbon Commission on America's Nuclearmore » Future (BRC) report [4] and are consistent with the aspirations of the key topics of the Strategic Research Agenda of the Implementing Geological Disposal of Radioactive Waste Technology Platform (IGD-TP) [5]. Against this background, a revival of joint efforts in salt repository investigations after some years of hibernation has been undertaken to leverage collective efforts in salt repository research, design, operations, and related issues for the benefit of respective programs and to form a basis for providing an attractive, cost-effective insurance against the premature loss of virtually irreplaceable scientific expertise and institutional memory. (authors)« less

The health effects of economic insecurity.

PubMed Central

Catalano, R

1991-01-01

BACKGROUND. Interest in the health and behavioral effects of economic insecurity appears to vary with the performance of the economy. The current recession in the United States and Western Europe and growing unemployment in Eastern Europe make it timely to analytically review the recent research concerned with the health effects of economic contraction. METHODS. The research concerned with the health and behavioral effects of economic insecurity is organized by dependent variable and method. Rules for determining which effects are supported by strong and which by weak evidence are developed and applied to the literature. RESULTS. Evidence for effects on symptoms of psychological distress, seeking help for psychological distress, and nonspecific physiological illness is strong. Evidence for effects on suicide, child abuse, adverse birth outcomes, and heart disease is characterized as weak or sufficiently controversial to warrant skepticism. CONCLUSIONS. The health effects of economic security are undoubtedly mediated by economic policies. Estimating the effect of policy alternatives on the incidence of various outcomes is, however, very difficult given the current state of the research. The effect of rising unemployment on health in Eastern Europe cannot, moreover, be estimated from existing research. Effects estimated from Western economies probably do not generalize to situations in which the meaning of economic insecurity is conditioned by profound social and political reforms. PMID:1951825

Optimization of Experimental Conditions of the Pulsed Current GTAW Parameters for Mechanical Properties of SDSS UNS S32760 Welds Based on the Taguchi Design Method

NASA Astrophysics Data System (ADS)

Yousefieh, M.; Shamanian, M.; Saatchi, A.

2012-09-01

Taguchi design method with L9 orthogonal array was implemented to optimize the pulsed current gas tungsten arc welding parameters for the hardness and the toughness of super duplex stainless steel (SDSS, UNS S32760) welds. In this regard, the hardness and the toughness were considered as performance characteristics. Pulse current, background current, % on time, and pulse frequency were chosen as main parameters. Each parameter was varied at three different levels. As a result of pooled analysis of variance, the pulse current is found to be the most significant factor for both the hardness and the toughness of SDSS welds by percentage contribution of 71.81 for hardness and 78.18 for toughness. The % on time (21.99%) and the background current (17.81%) had also the next most significant effect on the hardness and the toughness, respectively. The optimum conditions within the selected parameter values for hardness were found as the first level of pulse current (100 A), third level of background current (70 A), first level of % on time (40%), and first level of pulse frequency (1 Hz), while they were found as the second level of pulse current (120 A), second level of background current (60 A), second level of % on time (60%), and third level of pulse frequency (5 Hz) for toughness. The Taguchi method was found to be a promising tool to obtain the optimum conditions for such studies. Finally, in order to verify experimental results, confirmation tests were carried out at optimum working conditions. Under these conditions, there were good agreements between the predicted and the experimental results for the both hardness and toughness.

Effect of Background Pressure on the Performance and Plume of the HiVHAc Hall Thruster

NASA Technical Reports Server (NTRS)

Huang, Wensheng; Kamhawi, Hani; Haag, Thomas

2013-01-01

During the Single String Integration Test of the NASA HiVHAc Hall thruster, a number of plasma diagnostics were implemented to study the effect of varying facility background pressure on thruster operation. These diagnostics include thrust stand, Faraday probe, ExB probe, and retarding potential analyzer. The test results indicated a rise in thrust and discharge current with background pressure. There was also a decrease in ion energy per charge, an increase in multiply-charged species production, a decrease in plume divergence, and a decrease in ion beam current with increasing background pressure. A simplified ingestion model was applied to determine the maximum acceptable background pressure for thrust measurement. The maximum acceptable ingestion percentage was found to be around 1%. Examination of the diagnostics results suggest the ionization and acceleration zones of the thruster were shifting upstream with increasing background pressure.

[Opportunity for the integration of the gender perspective in health research and innovation in Europe: COST Network genderSTE].

PubMed

Sánchez de Madariaga, Inés; Ruiz Cantero, María Teresa

2014-01-01

The European Commission supports several routes for incorporating the gender perspective. The Commission currently supports the new Horizon 2020 program, and also funds projects such as "gendered innovations", which show how gender innovations increase the quality of research and professional practice for health and welfare. One of the policy instruments is the Recommendation on Gender, Science and Innovation. Against this background, the international European Cooperation in Science and Technology (COST) network genderSTE (Gender, Science, Technology and Environment) was created, which seeks to: 1) promote structural changes in institutions to increase the number of women researchers; 2) identify the gender dimensions relevant to the environment; and 3) improve the integration of a gender perspective in research and technology. COST GenderSTE supports networking and the dissemination of knowledge with a gender perspective. All these tools provide an opportunity to incorporate a gender perspective in research in Europe. Copyright © 2013 SESPAS. Published by Elsevier Espana. All rights reserved.

a Survey on Topics, Researchers and Cultures in the Field of Digital Heritage

NASA Astrophysics Data System (ADS)

Münster, S.

2017-08-01

Digital heritage comprises a broad variety of approaches and topics and involves researchers from multiple disciplines. While the use of digital methods in the text-oriented disciplines dealing with cultural heritage is widely discussed and canonized, an up-to-date investigation on cultural heritage as a scholarly field is currently missing. The extended abstract is about a three-stage investigation on standards, publications, disciplinary cultures as well as scholars in the field of digital heritage, carried out in 2016 and 2017. It includes results of a workshop-based survey involving 44 researchers, 15 qualitative interviews as well as an online survey with nearly 1000 participants. As an overall finding, a community is driven by researchers from European countries and especially Italy with a background in humanities, dealing with topics of data acquisition, data management and visualization. Moreover, conference series are most relevant for a scientific discourse, and especially EU projects set pace as most important research endeavours.

Apprenticeship in science research: whom does it serve?

NASA Astrophysics Data System (ADS)

Davies, Paul

2016-12-01

This article advances the thinking of Thompson, Conaway and Dolan's "Undergraduate students' development of social, cultural, and human capital in a network research experience". Set against a background of change in the biosciences, and participation, it firstly explores ideas of what it means to be a scientist, then challenges the current view of the apprenticeship model of career trajectory, before going onto to consider the nature of participation in communities of practice and issues related to underrepresented minority groups in science. Central to this analysis is the place that the notion of habitus plays in thinking about shaping future scientists and the how this can both support, but also suppress, opportunities for individuals through a maintenance of the status quo.

Design and Performance Estimates of an Ablative Gallium Electromagnetic Thruster

NASA Technical Reports Server (NTRS)

Thomas, Robert E.

2012-01-01

The present study details the high-power condensable propellant research being conducted at NASA Glenn Research Center. The gallium electromagnetic thruster is an ablative coaxial accelerator designed to operate at arc discharge currents in the range of 10-25 kA. The thruster is driven by a four-parallel line pulse forming network capable of producing a 250 microsec pulse with a 60 kA amplitude. A torsional-type thrust stand is used to measure the impulse of a coaxial GEM thruster. Tests are conducted in a vacuum chamber 1.5 m in diameter and 4.5 m long with a background pressure of 2 microtorr. Electromagnetic scaling calculations predict a thruster efficiency of 50% at a specific impulse of 2800 seconds.

Communicating Scientific Research to Non-Specialists

NASA Astrophysics Data System (ADS)

Holman, Megan

Public outreach to effectively communicate current scientific advances is an essential component of the scientific process. The challenge in making this information accessible is forming a clear, accurate, and concise version of the information from a variety of different sources, so that the information is understandable and compelling to non-specialists in the general public. We are preparing a magazine article about planetary system formation. This article will include background information about star formation and different theories and observations of planet formation to provide context. We will then discuss the latest research and theories describing how planetary systems may be forming in different areas of the universe. We demonstrate here the original professional-level scientific work alongside our public-level explanations and original graphics to demonstrate our editorial process.

Combining Induced Pluripotent Stem Cells and Genome Editing Technologies for Clinical Applications.

PubMed

Chang, Chia-Yu; Ting, Hsiao-Chien; Su, Hong-Lin; Jeng, Jing-Ren

2018-01-01

In this review, we introduce current developments in induced pluripotent stem cells (iPSCs), site-specific nuclease (SSN)-mediated genome editing tools, and the combined application of these two novel technologies in biomedical research and therapeutic trials. The sustainable pluripotent property of iPSCs in vitro not only provides unlimited cell sources for basic research but also benefits precision medicines for human diseases. In addition, rapidly evolving SSN tools efficiently tailor genetic manipulations for exploring gene functions and can be utilized to correct genetic defects of congenital diseases in the near future. Combining iPSC and SSN technologies will create new reliable human disease models with isogenic backgrounds in vitro and provide new solutions for cell replacement and precise therapies.

Executive functions: a discussion of the issues facing children with autism spectrum disorders and related disorders.

PubMed

Calhoun, James A

2006-02-01

The interest and attention devoted to executive functions has grown steadily in the last several decades. The concept and definitions of executive functions and their association with certain disorders such as autism spectrum disorders (ASD) and overall cognitive, social, emotional, and behavioral functioning are important knowledge areas for those working in education, health, and mental health-related fields. It is particularly important for providers to have an understanding of the basic issues related to assessment and remediation of executive dysfunction. This article briefly addresses the background, current definitions, research, and some intervention options associated with executive functions. The intent is to present a foundation for encouraging additional research on the issues relevant to this important topic.

Background radiation measurements at high power research reactors

NASA Astrophysics Data System (ADS)

Ashenfelter, J.; Balantekin, B.; Baldenegro, C. X.; Band, H. R.; Barclay, G.; Bass, C. D.; Berish, D.; Bowden, N. S.; Bryan, C. D.; Cherwinka, J. J.; Chu, R.; Classen, T.; Davee, D.; Dean, D.; Deichert, G.; Dolinski, M. J.; Dolph, J.; Dwyer, D. A.; Fan, S.; Gaison, J. K.; Galindo-Uribarri, A.; Gilje, K.; Glenn, A.; Green, M.; Han, K.; Hans, S.; Heeger, K. M.; Heffron, B.; Jaffe, D. E.; Kettell, S.; Langford, T. J.; Littlejohn, B. R.; Martinez, D.; McKeown, R. D.; Morrell, S.; Mueller, P. E.; Mumm, H. P.; Napolitano, J.; Norcini, D.; Pushin, D.; Romero, E.; Rosero, R.; Saldana, L.; Seilhan, B. S.; Sharma, R.; Stemen, N. T.; Surukuchi, P. T.; Thompson, S. J.; Varner, R. L.; Wang, W.; Watson, S. M.; White, B.; White, C.; Wilhelmi, J.; Williams, C.; Wise, T.; Yao, H.; Yeh, M.; Yen, Y.-R.; Zhang, C.; Zhang, X.; Prospect Collaboration

2016-01-01

Research reactors host a wide range of activities that make use of the intense neutron fluxes generated at these facilities. Recent interest in performing measurements with relatively low event rates, e.g. reactor antineutrino detection, at these facilities necessitates a detailed understanding of background radiation fields. Both reactor-correlated and naturally occurring background sources are potentially important, even at levels well below those of importance for typical activities. Here we describe a comprehensive series of background assessments at three high-power research reactors, including γ-ray, neutron, and muon measurements. For each facility we describe the characteristics and identify the sources of the background fields encountered. The general understanding gained of background production mechanisms and their relationship to facility features will prove valuable for the planning of any sensitive measurement conducted therein.

The Use of Sociocultural Constructs in Cancer Screening Research Among African Americans

PubMed Central

Deshpande, Anjali D.; Sanders Thompson, Vetta L.; Vaughn, Kimberlee P.; Kreuter, Matthew W.

2013-01-01

Background Studies are increasingly examining the role of sociocultural values, beliefs, and attitudes in cancer prevention. However, these studies vary widely in how sociocultural constructs are defined and measured, how they are conceived as affecting cancer beliefs, behaviors, and screening, and how they are applied in interventions. Methods To characterize the current state of this research literature, we conducted a critical review of studies published between 1990 and 2006 to describe the current use of sociocultural constructs in cancer screening research among African Americans. We included quantitative and qualitative studies with cancer as a primary focus that included African American participants, assessed screening behaviors, reported race-specific analyses, and considered one or more sociocultural factors. Studies were evaluated for type of cancer and screening analyzed, study population, methodology, sociocultural constructs considered, definitions of constructs, provision of psychometric data for measures, and journal characteristics. Results Of 94 studies identified for review, 35 met the inclusion criteria and were evaluated. Most focused on breast cancer screening, and thus African American women. Sociocultural constructs were seldom clearly defined, and the sources and psychometric properties of sociocultural measures were rarely reported. Conclusions A multidisciplinary approach to developing a common language and a standardized set of measures for sociocultural constructs will advance research in this area. Specific recommendations are made for future research. PMID:19556966

The state of research funding from the National Institutes of Health for criminal justice health research

PubMed Central

Ahalt, Cyrus; Bolano, Marielle; Wang, Emily A.; Williams, Brie

2015-01-01

Background Over 20 million Americans are currently incarcerated or have been in the past. Most are from medically underserved populations; one in three African American men and one in six Latino men born in 2001 are projected to go to prison during their lifetimes. The amount of funding from the National Institutes of Health (NIH) to understand and improve the health of criminal justice-involved persons is unknown. Objective Describe NIH funding for research addressing the health and healthcare needs of criminal justice-involved individuals. Design Review of NIH grants (from 2008 through 2012) in the RePORT (Research Portfolio Online Reporting Tools) database. Setting The NIH RePORT database. Patients Criminal justice involved individuals participating in NIH-funded clinical research. Measurements NIH research and training grants awarded by number, type, research area, institute or center, and dollar amount. Results Of more than 250,000 NIH funded grants, 180 (less than 0.1%) focused on criminal justice health research. The three most common foci of criminal justice health research grants were substance use and/or HIV (64%), mental health (11%), and juvenile health (8%). Two institutes, the National Institute on Drug Abuse and the National Institute of Mental Health, funded 78% of all grants. In 2012, the NIH invested $40.9 million in criminal justice health research, or 1.5% of the $2.7 billion health disparities budget for that year. Limitations NIH-supported research that did not explicitly include current or former prisoners but may have relevance to criminal justice health was not included. Conclusions Federal funding for research focused on understanding and improving the health of criminal justice-involved persons is small, even when compared to the NIH’s overall investment in health disparities research. The NIH is well-positioned to transform the care of current and former prisoners by investing in this critical yet overlooked research area. Primary Funding Source One author received funding support from the National Institute on Aging at the National Institutes of Health and Tideswell at UCSF. PMID:25732276

Visual interface for space and terrestrial analysis

NASA Technical Reports Server (NTRS)

Dombrowski, Edmund G.; Williams, Jason R.; George, Arthur A.; Heckathorn, Harry M.; Snyder, William A.

1995-01-01

The management of large geophysical and celestial data bases is now, more than ever, the most critical path to timely data analysis. With today's large volume data sets from multiple satellite missions, analysts face the task of defining useful data bases from which data and metadata (information about data) can be extracted readily in a meaningful way. Visualization, following an object-oriented design, is a fundamental method of organizing and handling data. Humans, by nature, easily accept pictorial representations of data. Therefore graphically oriented user interfaces are appealing, as long as they remain simple to produce and use. The Visual Interface for Space and Terrestrial Analysis (VISTA) system, currently under development at the Naval Research Laboratory's Backgrounds Data Center (BDC), has been designed with these goals in mind. Its graphical user interface (GUI) allows the user to perform queries, visualization, and analysis of atmospheric and celestial backgrounds data.

Reusable shielding material for neutron- and gamma-radiation

NASA Astrophysics Data System (ADS)

Calzada, Elbio; Grünauer, Florian; Schillinger, Burkhard; Türck, Harald

2011-09-01

At neutron research facilities all around the world radiation shieldings are applied to reduce the background of neutron and gamma radiation as far as possible in order to perform high quality measurements and to fulfill the radiation protection requirements. The current approach with cement-based compounds has a number of shortcomings: "Heavy concrete" contains a high amount of elements, which are not desired to obtain a high attenuation of neutron and/or gamma radiation (e.g. calcium, carbon, oxygen, silicon and aluminum). A shielding material with a high density of desired nuclei such as iron, hydrogen and boron was developed for the redesign of the neutron radiography facility ANTARES at beam tube 4 (located at a cold neutron source) of FRM-II. The composition of the material was optimized by help of the Monte Carlo code MCNP5. With this shielding material a considerable higher attenuation of background radiation can be obtained compared to usual heavy concretes.

Research teaching in learning disability nursing: Exploring the views of student and registered learning disability nurses.

PubMed

Northway, Ruth; Parker, Michelle; James, Neil; Davies, Lynsey; Johnson, Kaye; Wilson, Sally

2015-12-01

Whilst there is a need to develop the research base within learning disability nursing it is also significant that currently there is little published data as to how research is taught to this group of nurses. To increase understanding of how research is currently taught to learning disability nurses within the UK. A survey design was used. The research was undertaken at a conference held in the UK in March 2014. 310 learning disability nurses attending the conference of which 212 completed the free text question. This comprised student nurses (n=158), registered nurses working in practice settings (n=25) and registered nurses working in educational institutions (n=24). Five participants did not specify their background. Participants were invited to complete a questionnaire that included a free text question regarding the teaching of research to learning disability nurses: it is the responses to this question that are reported in this paper. Responses were transcribed and thematically analysed. Eight themes emerged: Teaching approach--the good and the bad; finding the right level; right from the start; we need more time; generic versus specialist; there's not enough; getting research into practice; and what should we focus on? Variations exist in terms of the timing of research education, the teaching approaches used, and hence the quality of student experience. Of particular concern is the apparent gap between research teaching and the use of research in practice, and the reported lack of support for research within practice settings. However, enthusiasm for research is evident and hence recommendations are made both to enhance teaching and to strengthen links with practice. Copyright © 2015 Elsevier Ltd. All rights reserved.

Heavy particle transport in sputtering systems

NASA Astrophysics Data System (ADS)

Trieschmann, Jan

2015-09-01

This contribution aims to discuss the theoretical background of heavy particle transport in plasma sputtering systems such as direct current magnetron sputtering (dcMS), high power impulse magnetron sputtering (HiPIMS), or multi frequency capacitively coupled plasmas (MFCCP). Due to inherently low process pressures below one Pa only kinetic simulation models are suitable. In this work a model appropriate for the description of the transport of film forming particles sputtered of a target material has been devised within the frame of the OpenFOAM software (specifically dsmcFoam). The three dimensional model comprises of ejection of sputtered particles into the reactor chamber, their collisional transport through the volume, as well as deposition of the latter onto the surrounding surfaces (i.e. substrates, walls). An angular dependent Thompson energy distribution fitted to results from Monte-Carlo simulations is assumed initially. Binary collisions are treated via the M1 collision model, a modified variable hard sphere (VHS) model. The dynamics of sputtered and background gas species can be resolved self-consistently following the direct simulation Monte-Carlo (DSMC) approach or, whenever possible, simplified based on the test particle method (TPM) with the assumption of a constant, non-stationary background at a given temperature. At the example of an MFCCP research reactor the transport of sputtered aluminum is specifically discussed. For the peculiar configuration and under typical process conditions with argon as process gas the transport of aluminum sputtered of a circular target is shown to be governed by a one dimensional interaction of the imposed and backscattered particle fluxes. The results are analyzed and discussed on the basis of the obtained velocity distribution functions (VDF). This work is supported by the German Research Foundation (DFG) in the frame of the Collaborative Research Centre TRR 87.

Progress of the Felsenkeller Shallow-Underground Accelerator for Nuclear Astrophysics

NASA Astrophysics Data System (ADS)

Bemmerer, D.; Cavanna, F.; Cowan, T. E.; Grieger, M.; Hensel, T.; Junghans, A. R.; Ludwig, F.; Müller, S. E.; Rimarzig, B.; Reinicke, S.; Schulz, S.; Schwengner, R.; Stöckel, K.; Szücs, T.; Takács, M. P.; Wagner, A.; Wagner, L.; Zuber, K.

Low-background experiments with stable ion beams are an important tool for putting the model of stellar hydrogen, helium, and carbon burning on a solid experimental foundation. The pioneering work in this regard has been done by the LUNA collaboration at Gran Sasso, using a 0.4 MV accelerator. In the present contribution, the status of the project for a higher-energy underground accelerator is reviewed. Two tunnels of the Felsenkeller underground site in Dresden, Germany, are currently being refurbished for the installation of a 5 MV high-current Pelletron accelerator. Construction work is on schedule and expected to complete in August 2017. The accelerator will provide intense, 50 µA, beams of 1H+, 4He+, and 12C+ ions, enabling research on astrophysically relevant nuclear reactions with unprecedented sensitivity.

Redox Strategies for Crop Improvement.

PubMed

Kerchev, Pavel; De Smet, Barbara; Waszczak, Cezary; Messens, Joris; Van Breusegem, Frank

2015-11-10

Recently, the agro-biotech industry has been driven by overcoming the limitations imposed by fluctuating environmental stress conditions on crop productivity. A common theme among (a)biotic stresses is the perturbation of the redox homeostasis. As a strategy to engineer stress-tolerant crops, many approaches have been centered on restricting the negative impact of reactive oxygen species (ROS) accumulation. In this study, we discuss the scientific background of the existing redox-based strategies to improve crop performance and quality. In this respect, a special focus goes to summarizing the current patent landscape because this aspect is very often ignored, despite constituting the forefront of applied research. The current increased understanding of ROS acting as signaling molecules has opened new avenues to exploit redox biology for crop improvement required for sustainable food security.

Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of Current Evidence

PubMed Central

Mashhadi, Nafiseh Shokri; Ghiasvand, Reza; Askari, Gholamreza; Hariri, Mitra; Darvishi, Leila; Mofid, Mohammad Reza

2013-01-01

Background: Ginger (Zingiber officinale Rosc.) belongs to the family Zingiberaceae. The health-promoting perspective of ginger is attributed to its rich phytochemistry. This study aimed to review the current evidence on ginger effects as an anti-inflammatory and anti-oxidative. Methods: We searched MEDLINE for related publications using “ginger” and “anti-oxidative” and “ginger” and “anti-inflammatory” as keywords. This search had considered Papers that had been published between 2000 and 2010 without any filter. Conclusions: The anticancer potential of ginger is well documented and its functional ingredients like gingerols, shogaol, and paradols are the valuable ingredients which can prevent various cancers. This review concludes to favor ginger but some ambiguities necessitate further research before claiming its efficacy. PMID:23717767

Using an instrumented manikin for Space Station Freedom analysis

NASA Technical Reports Server (NTRS)

Orr, Linda; Hill, Richard

1989-01-01

One of the most intriguing and complex areas of current computer graphics research is animating human figures to behave in a realistic manner. Believable, accurate human models are desirable for many everyday uses including industrial and architectural design, medical applications, and human factors evaluations. For zero-gravity (0-g) spacecraft design and mission planning scenarios, they are particularly valuable since 0-g conditions are difficult to simulate in a one-gravity Earth environment. At NASA/JSC, an in-house human modeling package called PLAID is currently being used to produce animations for human factors evaluation of Space Station Freedom design issues. Presented here is an introductory background discussion of problems encountered in existing techniques for animating human models and how an instrumented manikin can help improve the realism of these models.

Performance, Facility Pressure Effects, and Stability Characterization Tests of NASA's Hall Effect Rocket with Magnetic Shielding Thruster

NASA Technical Reports Server (NTRS)

Kamhawi, Hani; Huang, Wensheng; Haag, Thomas; Yim, John; Herman, Daniel; Williams, George; Gilland, James; Peterson, Peter; Hofer, Richard; Mikellides, Ioannis

2016-01-01

NASAs Hall Effect Rocket with Magnetic Shielding (HERMeS) 12.5 kW Technology Demonstration Unit-1 (TDU-1) Hall thruster has been the subject of extensive technology maturation in preparation for flight system development. Part of the technology maturation effort included experimental evaluation of the TDU-1 thruster with conducting and dielectric front pole cover materials in two different electrical configurations. A graphite front pole cover thruster configuration with the thruster body electrically tied to cathode and an alumina front pole cover thruster configuration with the thruster body floating were evaluated. Both configurations were also evaluated at different facility background pressure conditions to evaluate background pressure effects on thruster operation. Performance characterization tests found that higher thruster performance was attained with the graphite front pole cover configuration with the thruster electrically tied to cathode. A total thrust efficiency of 68 and a total specific impulse of 2,820 s was demonstrated at a discharge voltage of 600 V and a discharge power of 12.5 kW. Thruster stability regimes were characterized with respect to the thruster discharge current oscillations and with maps of the current-voltage-magnetic field (IVB). Analysis of TDU-1 discharge current waveforms found that lower normalized discharge current peak-to-peak and root mean square magnitudes were attained when the thruster was electrically floated with alumina front pole covers. Background pressure effects characterization tests indicated that the thruster performance and stability was mostly invariant to changes in the facility background pressure for vacuum chamber pressure below 110-5 Torr-Xe (for thruster flow rate above 8 mgs). Power spectral density analysis of the discharge current waveform showed that increasing the vacuum chamber background pressure resulted in a higher discharge current dominant frequency. Finally the IVB maps of the TDU-1 thruster taken at elevated magnetic fields indicated that the discharge current became more oscillatory with increased facility background pressure at lower thruster mass flow rates, where thruster operation at higher flow rates resulted in less change to the thrusters IVB characteristics.

Reevalution of background iodine-129 concentrations in water from the Snake River Plain Aquifer, Idaho, 2003

USGS Publications Warehouse

Cecil, L. DeWayne; Hall, L. Flint; Green, Jaromy R.

2003-01-01

Background concentrations of iodine-129 (129I, half-life = 15.7 million years) resulting from natural production in the earth?s atmosphere, in situ production in the earth by spontaneous fission of uranium-238(238U), and fallout from nuclear weapons tests conducted in the 1950s and 1960s were reevaluated on the basis of 52 analyses of ground- and surface-water samples collected from the eastern Snake River Plain in southeastern Idaho. The background concentration estimated using the results of a subset of 30 ground-water samples analyzed in this reevaluation is 5.4 attocuries per liter (aCi/L; 1 aCi = 10-18 curies) and the 95-percent nonparametric confidence interval is 5.2 to 10.0 aCi/L. In a previous study, a background 129I concentration was estimated on the basis of analyses of water samples from 16 sites on or tributary to the eastern Snake River Plain. At the 99-percent confidence level, background concentrations of 129I in that study were less than or equal to 8.2 aCi/L. During 1993?94, 34 water samples from 32 additional sites were analyzed for 129I to better establish the background concentrations in surface and ground water from the eastern Snake River Plain that is presumed to be unaffected by wastedisposal practices at the Idaho National Engineering and Environmental Laboratory (INEEL). Surface water contained larger 129I concentrations than water from springs and wells contained. Because surface water is more likely to be affected by anthropogenic fallout and evapotranspiration, background 129I concentrations were estimated in the current research using the laboratory results of ground-water samples that were assumed to be unaffected by INEEL disposal practices.

Pacing: A concept analysis of a chronic pain intervention

PubMed Central

Jamieson-Lega, Kathryn; Berry, Robyn; Brown, Cary A

2013-01-01

BACKGROUND: The intervention of pacing is regularly recommended for chronic pain patients. However, pacing is poorly defined and appears to be interpreted in varying, potentially contradictory manners within the field of chronic pain. This conceptual lack of clarity has implications for effective service delivery and for researchers’ ability to conduct rigorous study. An examination of the background literature demonstrates that while pacing is often one part of a multidisciplinary pain management program, outcome research is hindered by a lack of a clear and shared definition of this currently ill-defined construct. OBJECTIVES: To conduct a formal concept analysis of the term ‘pacing’. METHODS: A standardized concept analysis process (including literature scoping to identify all uses of the concept, analysis to determine defining attributes of the concept and identification of model, borderline and contrary cases) was used to determine what the concept of pacing does and does not represent within the current evidence base. RESULTS: A conceptual model including the core attributes of action, time, balance, learning and self-management emerged. From these attributes, an evidence-based definition for pacing was composed and distributed to stakeholders for review. After consideration of stakeholder feedback, the emergent definition of pacing was finalized as follows: “Pacing is an active self-management strategy whereby individuals learn to balance time spent on activity and rest for the purpose of achieving increased function and participation in meaningful activities”. CONCLUSION: The findings of the present concept analysis will help to standardize the use and definition of the term pacing across disciplines for the purposes of both pain management and research. PMID:23717825

Research as a standard of care in PICU

PubMed Central

Zimmerman, Jerry J.; Anand, Kanwaljeet J. S.; Meert, Kathleen L.; Willson, Douglas F.; Newth, Christopher J. L.; Harrison, Rick; Carcillo, Joseph A.; Berger, John; Jenkins, Tammara L.; Nicholson, Carol; Dean, J. Michael

2016-01-01

Background Excellence in clinical care coupled with basic and applied research reflects the maturation of a medical subspecialty, advances that field, and provides objective data for identifying best practices. Pediatric intensive care units (PICU) are uniquely suited for conducting translational and clinical research. Moreover, multiple investigations have reported that a majority of parents are interested in their children’s participation in clinical research, even when the research offers no direct benefit to their child. However, such activity may generate ethical conflict with bedside care providers trying to acutely identify the best approach for an individual critically ill child. Ultimately, this conflict may diminish enthusiasm for the generation of scientific evidence that supports application of evidence-based medicine into PICU clinical standard work. Objective Provide an overview of current state PICU clinical research strengths, liabilities, opportunities, and barriers, and contrast this with an established pediatric hematology-oncology iterative research model that constitutes a learning healthcare system. Design Narrative review of medical literature published in English. Conclusions Currently most PICU therapy is not evidence-based. Developing a learning healthcare system in the PICU integrates clinical research into usual practice and fosters a culture of evidence-based learning and continual care improvement. As PICU mortality has significantly decreased, identification and validation of patient-centered, clinically relevant research outcome measures other than mortality is essential for future clinical trial design. Because most pediatric critical illness may be classified as rare diseases, participation in research networks will facilitate iterative, collaborative, multi-institutional investigations that over time identify best practices to improve PICU outcomes. Despite real ethical challenges, critically ill children and their families should have the opportunity to participate in translational/clinical research whenever feasible. PMID:26513203

Leveraging Radioactive Waste Disposal at WIPP for Science

NASA Astrophysics Data System (ADS)

Rempe, N. T.

2008-12-01

Salt mines are radiologically much quieter than other underground environments because of ultra-low concentrations of natural radionuclides (U, Th, and K) in the host rock; therefore, the Waste Isolation Pilot Plant (WIPP), a government-owned, 655m deep geologic repository that disposes of radioactive waste in thick salt near Carlsbad, New Mexico, has for the last 15 years hosted highly radiation-sensitive experiments. Incidentally, Nature started her own low background experiment 250ma ago, preserving viable bacteria, cellulose, and DNA in WIPP salt. The Department of Energy continues to make areas of the WIPP underground available for experiments, freely offering its infrastructure and access to this unique environment. Even before WIPP started disposing of waste in 1999, the Room-Q alcove (25m x 10m x 4m) housed a succession of small experiments. They included development and calibration of neutral-current detectors by Los Alamos National Laboratory (LANL) for the Sudbury Neutrino Observatory, a proof-of-concept by Ohio State University of a flavor-sensitive neutrino detector for supernovae, and research by LANL on small solid- state dark matter detectors. Two currently active experiments support the search for neutrino-less double beta decay as a tool to better define the nature and mass of the neutrino. That these delicate experiments are conducted in close vicinity to, but not at all affected by, megacuries of radioactive waste reinforces the safety argument for the repository. Since 2003, the Majorana collaboration is developing and testing various detector designs inside a custom- built clean room in the Room-Q alcove. Already low natural background readings are reduced further by segmenting the germanium detectors, which spatially and temporally discriminates background radiation. The collaboration also demonstrated safe copper electro-forming underground, which minimizes cosmogenic background in detector assemblies. The largest currently used experimental space (100m x 10m x 6m) is the North Experimental Area (NExA). There, Enriched Xenon Observatory (EXO) collaborators have since mid-2007 been assembling and outfitting six modules and associated structures that were pre-assembled at Stanford University, then dismantled, and shipped to WIPP. Transporting the modules underground presented several interesting challenges, all of which were overcome. Access through increasingly cleaner joined modules leads to the class-100 clean room detector module. Inside, a time projection chamber (TPC) contains 200kg liquid Xe- 136 (the largest non-defense related stockpile of an enriched isotope ever assembled for research). After the experiment starts in early 2009, it is expected to run for 3-5 years. University of Pennsylvania researchers recently sampled WIPP salt to attempt measuring stable Ne-22, resulting from the interaction of cosmogenic muons with Na-23 and preserved in the halite lattice, to determine variations in the cosmic-radiation flux. They in turn could reveal the history of nearby supernovae. University of Chicago/Fermilab researchers evaluate whether to install a superheated-fluid bubble-chamber to search for weakly interacting massive particles (WIMPs). A helium-filled solar neutrino TPC, dark matter and neutron detectors, and proton-decay and supernova-neutrino detectors are other projects that were and are under discussion. Rounding out the spectrum of possibilities are experiments to investigate the effects of long-term ultra-low-dose radiation on cell cultures and laboratory animals to verify or falsify the linear, no- threshold hypothesis. WIPP welcomes additional proposals and projects.

Masticatory Muscle Sleep Background EMG Activity is Elevated in Myofascial TMD Patients

PubMed Central

Raphael, Karen G.; Janal, Malvin N.; Sirois, David A.; Dubrovsky, Boris; Wigren, Pia E.; Klausner, Jack J.; Krieger, Ana C.; Lavigne, Gilles J.

2013-01-01

Despite theoretical speculation and strong clinical belief, recent research using laboratory polysomnographic (PSG) recording has provided new evidence that frequency of sleep bruxism (SB) masseter muscle events, including grinding or clenching of the teeth during sleep, is not increased for women with chronic myofascial temporomandibular disorder (TMD). The current case-control study compares a large sample of women suffering from chronic myofascial TMD (n=124) with a demographically matched control group without TMD (n=46) on sleep background electromyography (EMG) during a laboratory PSG study. Background EMG activity was measured as EMG root mean square (RMS) from the right masseter muscle after lights out. Sleep background EMG activity was defined as EMG RMS remaining after activity attributable to SB, other orofacial activity, other oromotor activity and movement artifacts were removed. Results indicated that median background EMG during these non SB-event periods was significantly higher (p<.01) for women with myofascial TMD (median=3.31 μV and mean=4.98 μV) than for control women (median=2.83 μV and mean=3.88 μV) with median activity in 72% of cases exceeding control activity. Moreover, for TMD cases, background EMG was positively associated and SB event-related EMG was negatively associated with pain intensity ratings (0–10 numerical scale) on post sleep waking. These data provide the foundation for a new focus on small, but persistent, elevations in sleep EMG activity over the course of the night as a mechanism of pain induction or maintenance. PMID:24237356

Research Performed within the Non-Destructive Evaluation Team at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Burns, Erin A.

2004-01-01

Non-destructive testing is essential in many fields of manufacturing and research in order to perform reliable examination of potentially damaged materials and parts without destroying the inherent structure of the materials. Thus, the Non-Destructive Evaluation (NDE) Team at NASA Glenn Research Center partakes in various projects to improve materials testing equipment as well as analyze materials, material defects, and material deficiencies. Due to the array of projects within the NDE Team at this time, five research aims were supplemental to some current projects. A literature survey of "DE and testing methodologies as related to rocks was performed. Also, Mars Expedition Rover technology was assessed to understand the requirements for instrumentation in harsh space environments (e.g. temperature). Potential instrumentation and technologies were also considered and documented. The literature survey provided background and potential sources for a proposal to acquire funding for ultrasonic instrumentation on board a future Mars expedition. The laboratory uses a Santec Systems AcousticScope AS200 acoustography system. Labview code was written within the current program in order to improve the current performance of the acoustography system. A sample of Reinforced Carbon/Carbon (RCC) material from the leading edge of the space shuttle underwent various non-destructive tests (guided wave scanning, thermography, computed tomography, real time x-ray, etc.) in order to characterize its structure and examine possible defects. Guided wave scan data of a ceramic matrix composite (CMC) panel was reanalyzed utilizing image correlations and signal processing variables. Additional guided wave scans and thermography were also performed on the CMC panel. These reevaluated data and images will be used in future presentations and publications. An additional axis for the guided wave scanner was designed, constructed, and implemented. This additional axis allowed incremental spacing of the previously fixed transducers for ultrasonic velocity measurements.

Metabolic and Respiratory Costs of Increasing Song Amplitude in Zebra Finches

PubMed Central

Zollinger, Sue Anne; Goller, Franz; Brumm, Henrik

2011-01-01

Bird song is a widely used model in the study of animal communication and sexual selection, and several song features have been shown to reflect the quality of the singer. Recent studies have demonstrated that song amplitude may be an honest signal of current condition in males and that females prefer high amplitude songs. In addition, birds raise the amplitude of their songs to communicate in noisy environments. Although it is generally assumed that louder song should be more costly to produce, there has been little empirical evidence to support this assumption. We tested the assumption by measuring oxygen consumption and respiratory patterns in adult male zebra finches (Taeniopygia guttata) singing at different amplitudes in different background noise conditions. As background noise levels increased, birds significantly increased the sound pressure level of their songs. We found that louder songs required significantly greater subsyringeal air sac pressure than quieter songs. Though increased pressure is probably achieved by increasing respiratory muscle activity, these increases did not correlate with measurable increases in oxygen consumption. In addition, we found that oxygen consumption increased in higher background noise, independent of singing behaviour. This observation supports previous research in mammals showing that high levels of environmental noise can induce physiological stress responses. While our study did not find that increasing vocal amplitude increased metabolic costs, further research is needed to determine whether there are other non-metabolic costs of singing louder or costs associated with chronic noise exposure. PMID:21915258

Situation of young radiation oncologists, medical physicists and radiation biologists in German-speaking countries : Results from a web-based survey of the Young DEGRO working group.

PubMed

Krug, David; Baumann, Rene; Rieckmann, Thorsten; Fokas, Emmanouil; Gauer, Tobias; Niyazi, Maximilian

2016-08-01

The working group "Young DEGRO" (yDEGRO) was established in 2014 by the German Society of Radiation Oncology (DEGRO). We aimed to assess the current situation of young radiation oncologists, medical physicists and radiation biologists. An online survey that included 52 questions or statements was designed to evaluate topics related to training, clinical duties and research opportunities. Using the electronic mailing list of the DEGRO and contact persons at university hospitals in Germany as well as at four hospitals in Switzerland and Austria, young professionals employed in the field of radiation oncology were invited to participate in the survey. A total of 260 responses were eligible for analysis. Of the respondents 69 % had a professional background in medicine, 23 % in medical physics and 9 % in radiation biology. Median age was 33 years. There was a strong interest in research among the participants; however a clear separation between research, teaching and routine clinical duties was rarely present for radiation oncologists and medical physicists. Likewise, allocated time for research and teaching during regular working hours was often not available. For radiation biologists, a lack of training in clinical and translational research was stated. This survey details the current state of education and research opportunities in young radiation oncologists, medical physicists and radiation biologists. These results will form the basis for the future working program of the yDEGRO.

Investigating Galactic Structure with COBE/DIRBE and Simulation

NASA Technical Reports Server (NTRS)

Cohen, Martin

1999-01-01

In this work I applied the current version of the SKY model of the point source sky to the interpretation of the diffuse all-sky emission observed by COBE/DIRBE (Cosmic Background Explorer Satellite/Diffuse Infrared Background Experiment). The goal was to refine the SKY model using the all-sky DIRBE maps of the Galaxy, in order that a search could be made for an isotropic cosmic background."Faint Source Model" [FSM] was constructed to remove Galactic fore ground stars from the ZSMA products. The FSM mimics SKY version 1 but it was inadequate to seek cosmic background emission because of the sizeable residual emission in the ZSMA products after this starlight subtraction. At this point I can only support that such models are currently inadequate to reveal a cosmic background. Even SKY5 yields the same disappointing result.

A Cross-National Study on Mexico-US Migration, Substance Use and Substance Use Disorders

PubMed Central

Borges, Guilherme; Breslau, Joshua; Orozco, Ricardo; Tancredi, Daniel J.; Anderson, Heather; Aguilar-Gaxiola, Sergio; Mora, Maria-Elena Medina

2011-01-01

Background Epidemiologic research has consistently found lower prevalence of alcohol and drug use disorders among Hispanic immigrants to the US than among US-born Hispanics. Recent research has begun to examine how this change occurs in the process of assimilation in the US. We aimed to study immigration, US nativity, and return migration as risk factors for alcohol and drug use among people of Mexican origin in both the US and Mexico. Methods Data come from nationally representative surveys in the United States (2001–2003; n= 1208) and Mexico (2001–2002; n=5782). We used discrete time event history models to account for time-varying and time-invariant characteristics. Results We found no evidence that current Mexican immigrants in the US have higher risk for alcohol or alcohol use disorders than Mexicans living in Mexico, but current immigrants were at higher risk for drug use and drug use disorders. Current Mexican immigrants were at lower risk for drug use and drug disorders than US-born Mexican-Americans. US nativity, regardless of parent nativity, is the main factor associated with increasing use of alcohol and drugs. Among families of migrants and among return migrants we found increased risk for alcohol use, drug use and alcohol and drug use disorders. Evidence of selective migration and return of immigrants with disorders was found regarding alcohol use disorders only. Conclusions Research efforts that combine populations from sending and receiving countries are needed. This effort will require much more complex research designs that will call for true international collaboration. PMID:21296509

An exploration of the impact of family background factors on the science achievement of Afro-Caribbean and African American students in the United States

NASA Astrophysics Data System (ADS)

Pinder, Patrice J.

Ogbu and Simons (1998) defined voluntary immigrants as individuals who chose to migrate to the United States (U.S.). Involuntary immigrants are defined as individuals whose ancestors were brought to the U.S. by force (Obgu & Simons, 1998). There have been recent reports indicating that voluntary immigrants are outperforming involuntary immigrants (Fisher, 2005; Williams, Fleming, Jones, & Griffin, 2007). There seems to be a trend in voluntary immigrants exhibiting a higher academic achievement pattern than involuntary immigrants (Fisher, 2005; Rong & Preissle, 1998; Williams et al., 2007). However, the reason for the groups' differences in achievement has not been extensively explored. The primary objective of this research study was to explore the impact of family background on the academic achievement patterns of Afro-Caribbean and African American students in the United States. The study utilized two research designs; a causal-comparative and a correlational design. A questionnaire was distributed to a sample of eighty-seven high school students. Eighteen of the participants were Afro-Caribbean students, and sixty-seven were African American students. Chemistry test scores for the students were also provided. The results of the study indicated that Afro-Caribbean students outperformed African American students on the test of science achievement. The difference was statistically significant (t= 2.43, p<0.05). Additionally, results suggested that there were a few significant differences in Afro-Caribbean and African American students' family backgrounds. Moreover, the findings of this study suggest that the positive impact of arrival status on the first-generation of Afro-Caribbean immigrants may be influencing their children's academic success in science. The present study holds a few implications for parents and teachers of immigrant minority students. Additionally, the current researcher has offered several implications for future research on ethnicity, immigration pattern, parenting, and achievement.

Science and football: evaluating the influence of science on performance.

PubMed

Drust, B; Green, M

2013-01-01

The scientific study of football has its origins in the early research completed in the 1970's. Since these early efforts the available scientific knowledge base related to football has developed substantially. The ability of this scientific information to influence practice in the day-to-day activity of football organisations, especially elite teams, has been largely taken for granted. The close examination of this impact can lead to more uncertainty regarding the usefulness of the scientific data to the sport. Few articles are available that have attempted to critique the link between science and football practice. As such, the aims of this article are 2-fold; (i) to examine the historical background to "science and football" and to analyse the influence of sports science research on the current practice of coaches and practitioners within the sport and (ii) to identify potential ways to increase the influence of scientific research on practice in the "real world".

High infrasonic goniometry applied to the detection of a helicopter in a high activity environment

NASA Astrophysics Data System (ADS)

Chritin, Vincent; Van Lancker, Eric; Wellig, Peter; Ott, Beat

2016-10-01

A current concern of armasuisse is the feasibility of a fixed or mobile acoustic surveillance and recognition network of sensors allowing to permanently monitor the noise immissions of a wide range of aerial activities such as civil or military aviation, and other possible acoustic events such as transient events, subsonic or sonic booms or other. This objective requires an ability to detect, localize and recognize a wide range of potential acoustic events of interest, among others possibly parasitic acoustic events (natural and industrial events on the ground for example), and possibly high background noise (for example close to urban or high activity areas). This article presents a general discussion and conclusion about this problem, based on 20 years of experience totalizing a dozen of research programs or internal researches by IAV, with an illustration through one central specific experimental case-study carried out within the framework of an armasuisse research program.

Abandon or embrace: Functionalism perspective of photojournalists on Syrian refugees

NASA Astrophysics Data System (ADS)

Tsuroyya; Tandyonomanu, D.; Dharmawan, A.

2018-01-01

This research examines photojournalist’ perspectives of Syrian refugees in Europe, encoding, and dissemination processes. It employs a qualitative approach and functionalism perspective of mass media by sending questionnaires to voluntary respondents. The findings show sharing similar background and/or having experiences in the Middle Eastern countries highly influence the perspective of photojournalists on Syrian refugees. The encoding process covers through research of priority issues, target audience, trustworthiness of photos, and audience interpretation. The distribution method includes taking advantages of personal social media to promote the links of photos. As part of mass media industry, photojournalists play a crucial role to contribute to social integration, particularly, in creating a shared understanding between European community and Syrian refugees. The current research serves as a basis to future investigations on the perspective of European community towards Syrian refugees, whether or not their perspective is influenced by such photos.

The research and application of visual saliency and adaptive support vector machine in target tracking field.

PubMed

Chen, Yuantao; Xu, Weihong; Kuang, Fangjun; Gao, Shangbing

2013-01-01

The efficient target tracking algorithm researches have become current research focus of intelligent robots. The main problems of target tracking process in mobile robot face environmental uncertainty. They are very difficult to estimate the target states, illumination change, target shape changes, complex backgrounds, and other factors and all affect the occlusion in tracking robustness. To further improve the target tracking's accuracy and reliability, we present a novel target tracking algorithm to use visual saliency and adaptive support vector machine (ASVM). Furthermore, the paper's algorithm has been based on the mixture saliency of image features. These features include color, brightness, and sport feature. The execution process used visual saliency features and those common characteristics have been expressed as the target's saliency. Numerous experiments demonstrate the effectiveness and timeliness of the proposed target tracking algorithm in video sequences where the target objects undergo large changes in pose, scale, and illumination.

HIV Therapy Simulator: a graphical user interface for comparing the effectiveness of novel therapy regimens.

PubMed

Lim, Huat Chye; Curlin, Marcel E; Mittler, John E

2011-11-01

Computer simulation models can be useful in exploring the efficacy of HIV therapy regimens in preventing the evolution of drug-resistant viruses. Current modeling programs, however, were designed by researchers with expertise in computational biology, limiting their accessibility to those who might lack such a background. We have developed a user-friendly graphical program, HIV Therapy Simulator (HIVSIM), that is accessible to non-technical users. The program allows clinicians and researchers to explore the effectiveness of various therapeutic strategies, such as structured treatment interruptions, booster therapies and induction-maintenance therapies. We anticipate that HIVSIM will be useful for evaluating novel drug-based treatment concepts in clinical research, and as an educational tool. HIV Therapy Simulator is freely available for Mac OS and Windows at http://sites.google.com/site/hivsimulator/. jmittler@uw.edu. Supplementary data are available at Bioinformatics online.

Population Health Management for Older Adults

PubMed Central

Tkatch, Rifky; Musich, Shirley; MacLeod, Stephanie; Alsgaard, Kathleen; Hawkins, Kevin; Yeh, Charlotte S.

2016-01-01

Background: The older adult population is expanding, living longer, with multiple chronic conditions. Understanding and managing their needs over time is an integral part of defining successful aging. Population health is used to describe the measurement and health outcomes of a population. Objectives: To define population health as applied to older adults, summarize lessons learned from current research, and identify potential interventions designed to promote successful aging and improved health for this population. Method: Online search engines were utilized to identify research on population health and health interventions for older adults. Results: Population health management (PHM) is one strategy to promote the health and well-being of target populations. Interventions promoting health across a continuum tend to be disease, risk, or health behavior specific rather than encompassing a global concept of health. Conclusion: Many existing interventions for older adults are simply research based with limited generalizability; as such, further work in this area is warranted. PMID:28680938

Toroidal Localized Spoof Plasmons on Compact Metadisks.

PubMed

Qin, Pengfei; Yang, Yihao; Musa, Muhyiddeen Yahya; Zheng, Bin; Wang, Zuojia; Hao, Ran; Yin, Wenyan; Chen, Hongsheng; Li, Erping

2018-03-01

Localized spoof surface plasmons (LSSPs) have recently emerged as a new research frontier due to their unique properties and increasing applications. Despite the importance, most of the current researches only focus on electric/magnetic LSSPs. Very recent research has revealed that toroidal LSSPs, LSSPs modes with multipole toroidal moments, can be achieved at a point defect in a 2D groove metal array. However, this metamaterial shows the limitations of large volume and poor compatibility to photonic integrated circuits. To overcome the above challenges, here it is proposed and experimentally demonstrated compact planar metadisks based on split ring resonators to support the toroidal LSSPs at microwave frequencies. Additionally, it is experimentally demonstrated that the toroidal LSSPs resonance is very sensitive to the structure changes and the background medium. These might facilitate its utilization in the design and application of plasmonic deformation sensors and the refractive index sensors.

Adolescents and Pornography: A Review of 20 Years of Research.

PubMed

Peter, Jochen; Valkenburg, Patti M

2016-01-01

The goal of this review was to systematize empirical research that was published in peer-reviewed English-language journals between 1995 and 2015 on the prevalence, predictors, and implications of adolescents' use of pornography. This research showed that adolescents use pornography, but prevalence rates varied greatly. Adolescents who used pornography more frequently were male, at a more advanced pubertal stage, sensation seekers, and had weak or troubled family relations. Pornography use was associated with more permissive sexual attitudes and tended to be linked with stronger gender-stereotypical sexual beliefs. It also seemed to be related to the occurrence of sexual intercourse, greater experience with casual sex behavior, and more sexual aggression, both in terms of perpetration and victimization. The findings of this review need to be seen against the background of various methodological and theoretical shortcomings, as well as several biases in the literature, which currently precludes internally valid causal conclusions about effects of pornography on adolescents.

Clearing the haze: the complexities and challenges of research on state marijuana laws.

PubMed

Choo, Esther K; Emery, Sherry L

2017-04-01

As states increasingly liberalize marijuana laws, high-quality research is needed that will inform the public and policymakers about the health and societal impact of these laws. However, there are many challenges to studying marijuana policy, including the heterogeneity of the drug and its use, the variability in the laws and their implementation from state to state, the need to capture a wide variety of relevant outcomes, and the poorly understood influence of marijuana commercialization. Furthermore, current instruments generally fail to distinguish between types of users and lack accurate and detailed measures of use. This review provides a background on marijuana laws in the United States and an overview of existing policy research, discusses methodological considerations when planning analysis of state marijuana laws, and highlights specific topics needing further development and investigation. © 2016 New York Academy of Sciences.

Reprint of Mechanisms of maintaining high suspended sediment concentration over tide-dominated offshore shoals in the southern Yellow Sea

NASA Astrophysics Data System (ADS)

Xiong, Jilian; Wang, Xiao Hua; Wang, Ya Ping; Chen, Jingdong; Shi, Benwei; Gao, Jianhua; Yang, Yang; Yu, Qian; Li, Mingliang; Yang, Lei; Gong, Xulong

2018-06-01

An understanding of the dynamics and behaviors of suspended sediments is vital in analysis of morphological, environmental, and ecological processes occurring in coastal marine environments. To study the mechanisms of maintaining high suspended sediment concentrations (SSCs) on a tide-dominated offshore shoal, we measured water depths, current velocities, SSCs, wave parameters and bottom sediment compositions in the southern Yellow Sea. These data were then used to calculate bottom shear stresses generated by currents (τc), waves (τw), and wave-current interactions (τcw). SSCs time series exhibited strong quarter-diurnal peaks during spring tides, in contrast to the semidiurnal signal during neap tides. A Fourier analysis showed that suspended sediment variations within tidal cycles was mainly controlled by resuspension in most stations. There existed relatively stable background SSCs (maintaining high SSCs among tidal cycles) values at all four stations during both windy (wind speed > 9.0 m/s) and normal weather conditions (wind speed < 3.0 m/s). The background SSCs had strong relationship with spring/neap-averaged τcw, indicating background SSCs were mainly controlled by mean bottom shear stress, with a minimum value of 0.21 N/m2. On account of the strong tidal currents, background SSCs of spring tides were greater than that of neap tides. In addition, on the base of wavelet, statistics analyses and turbulence dissipation parameter, background SSCs during slack tide in the study area may be maintained by intermittent turbulence events induced by a combined tidal current and wave action.

Mechanisms of maintaining high suspended sediment concentration over tide-dominated offshore shoals in the southern Yellow Sea

NASA Astrophysics Data System (ADS)

Xiong, Jilian; Wang, Xiao Hua; Wang, Ya Ping; Chen, Jingdong; Shi, Benwei; Gao, Jianhua; Yang, Yang; Yu, Qian; Li, Mingliang; Yang, Lei; Gong, Xulong

2017-05-01

An understanding of the dynamics and behaviors of suspended sediments is vital in analysis of morphological, environmental, and ecological processes occurring in coastal marine environments. To study the mechanisms of maintaining high suspended sediment concentrations (SSCs) on a tide-dominated offshore shoal, we measured water depths, current velocities, SSCs, wave parameters and bottom sediment compositions in the southern Yellow Sea. These data were then used to calculate bottom shear stresses generated by currents (τc), waves (τw), and wave-current interactions (τcw). SSCs time series exhibited strong quarter-diurnal peaks during spring tides, in contrast to the semidiurnal signal during neap tides. A Fourier analysis showed that suspended sediment variations within tidal cycles was mainly controlled by resuspension in most stations. There existed relatively stable background SSCs (maintaining high SSCs among tidal cycles) values at all four stations during both windy (wind speed > 9.0 m/s) and normal weather conditions (wind speed < 3.0 m/s). The background SSCs had strong relationship with spring/neap-averaged τcw, indicating background SSCs were mainly controlled by mean bottom shear stress, with a minimum value of 0.21 N/m2. On account of the strong tidal currents, background SSCs of spring tides were greater than that of neap tides. In addition, on the base of wavelet, statistics analyses and turbulence dissipation parameter, background SSCs during slack tide in the study area may be maintained by intermittent turbulence events induced by a combined tidal current and wave action.

Firearm Acquisition Without Background Checks: Results of a National Survey.

PubMed

Miller, Matthew; Hepburn, Lisa; Azrael, Deborah

2017-02-21

In 1994, 40% of U.S. gun owners who had recently acquired a firearm did so without a background check. No contemporary estimates exist. To estimate the proportion of current U.S. gun owners who acquired their most recent firearm without a background check, by time since and manner of acquisition, for the nation as a whole and separately in states with and without legislation regulating private sales. Probability-based online survey. United States, 2015. 1613 adult gun owners. Current gun owners were asked where and when they acquired their last firearm; if they purchased the firearm; and whether, as part of that acquisition, they had a background check (or were asked to show a firearm license or permit). 22% (95% CI, 16% to 27%) of gun owners who reported obtaining their most recent firearm within the previous 2 years reported doing so without a background check. For firearms purchased privately within the previous 2 years (that is, other than from a store or pawnshop, including sales between individuals in person, online, or at gun shows), 50% (CI, 35% to 65%) were obtained without a background check. This percentage was 26% (CI, 5% to 47%) for owners residing in states regulating private firearm sales and 57% (CI, 40% to 75%) for those living in states without regulations on private firearm sales. Potential inaccuracies due to recall and social desirability bias. 22% of current U.S. gun owners who acquired a firearm within the past 2 years did so without a background check. Although this represents a smaller proportion of gun owners obtaining firearms without background checks than in the past, millions of U.S. adults continue to acquire guns without background checks, especially in states that do not regulate private firearm sales. Fund for a Safer Future and the Joyce Foundation.

Inquiring Informationists: A Qualitative Exploration of Our Role.

PubMed

Robison, Rex R; Ryan, Mary E; Cooper, I Diane

2009-01-01

OBJECTIVE: The goal of this study is to explore the impact of an informationist program at the National Institutes of Health (NIH) Library and to provide a basis for further program assessment. In 2001 the NIH Library began its informationist program, where librarians with training in both biomedicine and information science work alongside researchers. The goal of the program is to facilitate researchers' access to and usage of information resources. METHODS: The researchers used qualitative interviews with key informants to characterize the current informationist services of user groups. Subjects were selected to capture a variety of activities that would show patterns of how the program assists the researchers of various NIH groups. Following the interviews, the authors extracted recurring and significant themes from the subjects' comments. RESULTS: Interview subjects provided their views on the informationists' skills, impact, and team participation. Research results documented that informationists helped find resources, provided instruction, and worked as part of the research team. The NIH groups currently using this service value their informationists' knowledge of library resources and their ability to access information needs quickly. The informationists' skills in finding information save the researchers time, increase the efficiency of the research team, and complement the contributions of other team members. Training by informationists was found useful. Informationist services led to increased self-reported library use, albeit in some cases this use was entirely via the informationist. CONCLUSIONS: Informationists saved researchers time by obtaining requested information, finding esoteric or unfamiliar resources, and providing related training. These activities appeared to be facilitated by the acceptance of the informationist as part of the research team. This exploratory study provides background that should be useful in future, more extensive evaluations.

Substance P Depolarizes Lamprey Spinal Cord Neurons by Inhibiting Background Potassium Channels.

PubMed

Thörn Pérez, Carolina; Hill, Russell H; Grillner, Sten

2015-01-01

Substance P is endogenously released in the adult lamprey spinal cord and accelerates the burst frequency of fictive locomotion. This is achieved by multiple effects on interneurons and motoneurons, including an attenuation of calcium currents, potentiation of NMDA currents and reduction of the reciprocal inhibition. While substance P also depolarizes spinal cord neurons, the underlying mechanism has not been resolved. Here we show that effects of substance P on background K+ channels are the main source for this depolarization. Hyperpolarizing steps induced inward currents during whole-cell voltage clamp that were reduced by substance P. These background K+ channels are pH sensitive and are selectively blocked by anandamide and AVE1231. These blockers counteracted the effect of substance P on these channels and the resting membrane potential depolarization in spinal cord neurons. Thus, we have shown now that substance P inhibits background K+ channels that in turn induce depolarization, which is likely to contribute to the frequency increase observed with substance P during fictive locomotion.

Substance P Depolarizes Lamprey Spinal Cord Neurons by Inhibiting Background Potassium Channels

PubMed Central

Thörn Pérez, Carolina; Hill, Russell H.; Grillner, Sten

2015-01-01

Substance P is endogenously released in the adult lamprey spinal cord and accelerates the burst frequency of fictive locomotion. This is achieved by multiple effects on interneurons and motoneurons, including an attenuation of calcium currents, potentiation of NMDA currents and reduction of the reciprocal inhibition. While substance P also depolarizes spinal cord neurons, the underlying mechanism has not been resolved. Here we show that effects of substance P on background K+ channels are the main source for this depolarization. Hyperpolarizing steps induced inward currents during whole-cell voltage clamp that were reduced by substance P. These background K+ channels are pH sensitive and are selectively blocked by anandamide and AVE1231. These blockers counteracted the effect of substance P on these channels and the resting membrane potential depolarization in spinal cord neurons. Thus, we have shown now that substance P inhibits background K+ channels that in turn induce depolarization, which is likely to contribute to the frequency increase observed with substance P during fictive locomotion. PMID:26197458

A Survey of Elementary and Secondary Music Educators' Professional Background, Teaching Responsibilities and Job Satisfaction in the United States

ERIC Educational Resources Information Center

Matthews, Wendy K.; Koner, Karen

2017-01-01

The focus of this exploratory study was to examine the current trends of K-12 music educators in the United States regarding their (a) professional background, (b) classroom teaching responsibilities, and (c) job satisfaction. Participants included seven thousand four hundred and sixty-three (N = 7,463) currently employed music teachers who were…

[CALCULATION OF THE PROBABILITY OF METALS INPUT INTO AN ORGANISM WITH DRINKING POTABLE WATERS].

PubMed

Tunakova, Yu A; Fayzullin, R I; Valiev, V S

2015-01-01

The work was performed in framework of the State program for the improvement of the competitiveness of Kazan (Volga) Federal University among the world's leading research and education centers and subsidies unveiled to Kazan Federal University to perform public tasks in the field of scientific research. In the current methodological recommendations "Guide for assessing the risk to public health under the influence of chemicals that pollute the environment," P 2.1.10.1920-04 there is regulated the determination of quantitative and/or qualitative characteristics of the harmful effects to human health from exposure to environmental factors. We proposed to complement the methodological approaches presented in P 2.1.10.1920-04, with the estimation of the probability of pollutants input in the body with drinking water which is the greater, the higher the order of the excess of the actual concentrations of the substances in comparison with background concentrations. In the paper there is proposed a method of calculation of the probability of exceeding the actual concentrations of metal cations above the background in samples of drinking water consumed by the population, which were selected at the end points of consumption in houses and apartments, to accommodate the passage of secondary pollution ofwater pipelines and distributing paths. Research was performed on the example of Kazan, divided into zones. The calculation of probabilities was made with the use of Bayes' theorem.

Video-Based Eye Tracking in Sex Research: A Systematic Literature Review.

PubMed

Wenzlaff, Frederike; Briken, Peer; Dekker, Arne

2015-12-21

Although eye tracking has been used for decades, it has gained popularity in the area of sex research only recently. The aim of this article is to examine the potential merits of eye tracking for this field. We present a systematic review of the current use of video-based eye-tracking technology in this area, evaluate the findings, and identify future research opportunities. A total of 34 relevant studies published between 2006 and 2014 were identified for inclusion by means of online databases and other methods. We grouped them into three main areas of research: body perception and attractiveness, forensic research, and sexual orientation. Despite the methodological and theoretical differences across the studies, eye tracking has been shown to be a promising tool for sex research. The article suggests there is much potential for further studies to employ this technique because it is noninvasive and yet still allows for the assessment of both conscious and unconscious perceptional processes. Furthermore, eye tracking can be implemented in investigations of various theoretical backgrounds, ranging from biology to the social sciences.

Harnessing and blending the power of two research networks to improve prevention science and public health practice

PubMed Central

Vanderpool, Robin C.; Brownson, Ross C.; Mays, Glen P.; Crosby, Richard A.; Wyatt, Stephen W.

2015-01-01

Strategic collaborations are essential in moving public health research and practice forward1, particularly in light of escalating fiscal and environmental challenges facing the public health community. This commentary provides background and context for an emerging partnership between two national networks, Prevention Research Centers (PRCs) and Public Health Practice-Based Research Networks (PBRNs), to impact public health practice. Supported by CDC, PRCs are celebrating over 25 years of transdisciplinary applied prevention research grounded in community and stakeholder engagement. Public Health PBRNs, funded by the Robert Wood Johnson Foundation, conduct innovative public health services and systems research with public health agencies and community partners to improve public health decision-making. By utilizing each of the networks’ respective strengths and resources, collaborative ventures between PRCs and Public Health PBRNs can enhance the translation of applied prevention research to evidence-based practice and empirically investigate novel public health practices developed in the field. Three current PRC-Public Health PBRNs projects are highlighted and future research directions are discussed. Improving the interconnectedness of prevention research and public health practice is essential to improve the health of the Nation. PMID:24237918

Beyond "Two Cultures": Guidance for Establishing Effective Researcher/Health System Partnerships

PubMed Central

Bowen, Sarah; Botting, Ingrid; Graham, Ian D.; Huebner, Lori-Anne

2017-01-01

Background: The current literature proposing criteria and guidelines for collaborative health system research often fails to differentiate between: (a) various types of partnerships, (b) collaborations formed for the specific purpose of developing a research proposal and those based on long-standing relationships, (c) researcher vs. decision-maker initiatives, and (d) the underlying drivers for the collaboration. Methods: Qualitative interviews were conducted with 16 decision-makers and researchers who partnered on a Canadian major peer-reviewed grant proposal in 2013. Objectives of this exploration of participants’ experiences with health system research collaboration were to: (a) explore perspectives and experience with research collaboration in general; (b) identify characteristics and strategies associated with effective partnerships; and (c) provide guidance for development of effective research partnerships. Interviews were audio-recorded and transcribed: transcripts were qualitatively analyzed using a general inductive approach. Results: Findings suggest that the common "two cultures" approach to research/decision-maker collaboration provides an inadequate framework for understanding the complexity of research partnerships. Many commonly-identified challenges to researcher/knowledge user (KU) collaboration are experienced as manageable by experienced research teams. Additional challenges (past experience with research and researchers; issues arising from previous collaboration; and health system dynamics) may be experienced in partnerships based on existing collaborations, and interact with partnership demands of time and communication. Current research practice may discourage KUs from engaging in collaborative research, in spite of strong beliefs in its potential benefits. Practical suggestions for supporting collaborations designed to respond to real-time health system challenges were identified. Conclusion: Participants’ experience with previous research activities, factors related to the established collaboration, and interpersonal, intra- and inter-organizational dynamics may present additional challenges to research partnerships built on existing collaboration. Differences between researchers and KUs may pose no greater challenges than differences among KUs (at various levels, and representing diverse perspectives and organizations) themselves. Effective "relationship brokering" is essential for meaningful collaboration. PMID:28005540

It's like a juggling act: rheumatoid arthritis patient perspectives on daily life and flare while on current treatment regimes.

PubMed

Flurey, Caroline A; Morris, Marianne; Richards, Pam; Hughes, Rodney; Hewlett, Sarah

2014-04-01

The objective of this study was to explore patients' experiences of RA daily life while on modern treatments. The methods of this study comprised semi-structured interviews with 15 RA patients, analysed using inductive thematic analysis. Four themes suggest patients experience life with RA along a continuum from RA in the background to the foreground of their lives, underpinned by constant actions to maintain balance. Living with RA in the background shows patients experience continuous, daily symptoms, which they mediate through micromanagement (mediating the impact of RA on daily life), while learning to incorporate RA into their identity (redefining me). RA moving into the foreground shows patients experience fluctuating symptoms (unwelcome reminders) that may or may not lead to a flare (trying to make sense of fluctuation). Dealing with RA in the foreground shows how patients attempt to manage RA flares (trying to regain control) and decide to seek medical help only after feeling they are losing control. Patients employ a stepped approach to self-management (mediation ladder) as symptoms increase, with seeking medical help often seen as the last resort. Patients seek to find a balance between managing their fluctuating RA and living their daily lives. Patients move back and forth along a continuum of RA in the background vs the foreground by balancing self-management of symptoms and everyday life. Clinicians need to appreciate that daily micromanagement is needed, even on current treatment regimes. Further research is needed to quantify the level and impact of daily symptoms and identify barriers and facilitators to seeking help.

Current Translational Research and Murine Models For Duchenne Muscular Dystrophy

PubMed Central

Rodrigues, Merryl; Echigoya, Yusuke; Fukada, So-ichiro; Yokota, Toshifumi

2016-01-01

Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder characterized by progressive muscle degeneration. Mutations in the DMD gene result in the absence of dystrophin, a protein required for muscle strength and stability. Currently, there is no cure for DMD. Since murine models are relatively easy to genetically manipulate, cost effective, and easily reproducible due to their short generation time, they have helped to elucidate the pathobiology of dystrophin deficiency and to assess therapies for treating DMD. Recently, several murine models have been developed by our group and others to be more representative of the human DMD mutation types and phenotypes. For instance, mdx mice on a DBA/2 genetic background, developed by Fukada et al., have lower regenerative capacity and exhibit very severe phenotype. Cmah-deficient mdx mice display an accelerated disease onset and severe cardiac phenotype due to differences in glycosylation between humans and mice. Other novel murine models include mdx52, which harbors a deletion mutation in exon 52, a hot spot region in humans, and dystrophin/utrophin double-deficient (dko), which displays a severe dystrophic phenotype due the absence of utrophin, a dystrophin homolog. This paper reviews the pathological manifestations and recent therapeutic developments in murine models of DMD such as standard mdx (C57BL/10), mdx on C57BL/6 background (C57BL/6-mdx), mdx52, dystrophin/utrophin double-deficient (dko), mdxβgeo, Dmd-null, humanized DMD (hDMD), mdx on DBA/2 background (DBA/2-mdx), Cmah-mdx, and mdx/mTRKO murine models. PMID:27854202

Reconsidering the methodology of “stress” research in inflammatory bowel disease

PubMed Central

Keefer, Laurie; Keshavarzian, Ali; Mutlu, Ece

2009-01-01

Background and Aims The goals of this paper are: 1) to critically review and analyze the methodology of the studies since 1990 linking stress to inflammatory bowel disease; and 2) to make recommendations for future research in this area of research. Methods Articles were restricted to empirical reports in the English language with human subjects. Eleven empirical articles were able to answer “How is psychological stress related to inflammation and/or the expression or course of inflammatory bowel disease?” Results Studies varied by choice of participant groups, method for classifying disease activity, choice of design, and definition and measurement of stress. Only half of the studies supported the hypothesis that stress affected IBD in some way. Conclusions Current methodological limitations in the stress and gut inflammation research have made it difficult for us to ascertain the role of stress in inflammatory bowel disease. Authors provide a checklist of items to consider when designing future studies. PMID:21172210

Golf and upper limb injuries: a summary and review of the literature

PubMed Central

McHardy, Andrew J; Pollard, Henry P

2005-01-01

Background Golf is a popular past time that provides exercise with social interaction. However, as with all sports and activities, injury may occur. Many golf-related injuries occur in the upper limb, yet little research on the potential mechanisms of these injuries has been conducted. Objective To review the current literature on golf-related upper limb injuries and report on potential causes of injury as it relates to the golf swing. Discussion An overview of the golf swing is described in terms of its potential to cause the frequently noted injuries. Most injuries occur at impact when the golf club hits the ball. This paper concludes that more research into golf-related upper limb injuries is required to develop a thorough understanding of how injuries occur. Types of research include epidemiology studies, kinematic swing analysis and electromyographic studies of the upper limb during golf. By conducting such research, preventative measures maybe developed to reduce golf related injury. PMID:15967021

Collaboration Strategies in Nontraditional Community-Based Participatory Research Partnerships: Lessons From an Academic–Community Partnership With Autistic Self-Advocates

PubMed Central

Nicolaidis, Christina; Raymaker, Dora; McDonald, Katherine; Dern, Sebastian; Ashkenazy, Elesia; Boisclair, Cody; Robertson, Scott; Baggs, Amanda

2012-01-01

Background Most community-based participatory research (CBPR) projects involve local communities defined by race, ethnicity, geography, or occupation. Autistic self-advocates, a geographically dispersed community defined by disability, experience issues in research similar to those expressed by more traditional minorities. Objectives We sought to build an academic–community partnership that uses CBPR to improve the lives of people on the autistic spectrum. Methods The Academic Autistic Spectrum Partnership in Research and Education (AASPIRE) includes representatives from academic, self-advocate, family, and professional communities. We are currently conducting several studies about the health care experiences and well-being of autistic adults. Lessons Learned We have learned a number of strategies that integrate technology and process to successfully equalize power and accommodate diverse communication and collaboration needs. Conclusions CBPR can be conducted successfully with autistic self-advocates. Our strategies may be useful to other CBPR partnerships, especially ones that cannot meet in person or that include people with diverse communication needs. PMID:21623016

A melding of the minds: when primatology meets personality and social psychology.

PubMed

Brosnan, Sarah F; Newton-Fisher, Nicholas E; van Vugt, Mark

2009-05-01

Social and personality psychology and behavioral primatology both enjoy long histories of research aimed at uncovering the proximate and ultimate determinants of primate-human and nonhuman-social behavior. Although they share research themes, methodologies, and theories, and although their studied species are closely related, there is currently very little interaction between the fields. This separation means that researchers in these disciplines miss out on opportunities to advance understanding by combining insights from both fields. Social and personality psychologists also miss the opportunity for a phylogenetic analysis. The time has come to integrate perspectives on primate social psychology. Here, the authors provide a historical background and document the main similarities and differences in approaches. Next, they present some examples of research programs that may benefit from an integrated primate perspective. Finally, the authors propose a framework for developing a social psychology inclusive of all primates. Such a melding of minds promises to greatly benefit those who undertake the challenge.

Co-Creating theories and research design for an interdisciplinary project dealing with capacity building for people with migration background in Austria

NASA Astrophysics Data System (ADS)

Weber, Karin; Tscharner, Susanna; Stickler, Therese; Fuchs, Britta; Damyanovic, Doris; Hübl, Johannes

2017-04-01

Understanding spatial and social aspects of vulnerability is of growing importance in the context of climate change and natural hazards. The interplay of structural factors, socio-demographic aspects, current risk communication strategies, spatial planning instruments and related processes and the current spatial and environmental situation, including hazards and hazard zones, geographical locations, building and settlement types, contributing to people`s vulnerabilities needs to be analysed and understood to reduce vulnerability and to foster resilience. The project "CCCapMig" (Climate change and capacity building for people with migration background in Austria) aims at linking spatial and technical, as well as organisational and social aspects of climate change and natural hazards. This paper focuses on the co-creation of the theoretical framework and concepts and outlines the research design for this interdisciplinary cross-analysis of several case studies in rural Austria. The project is designed as an inter- and transdisciplinary survey and brings together engineering sciences, spatial sciences and social sciences. Reflecting the interdisciplinary approach, a theoretical framework was developed that refers to a combination of both theories and frameworks from vulnerability research, theories of risk perception and spatial theories and methods like the Sustainable Livelihoods Framework, the Protection-Motivation Theory and Landscape-Planning Theories: The "Sustainable Livelihoods Framework" adapted (by FA0) for disaster risk management offers an analytical framework to understand the emergence of vulnerabilities from the perspective of people`s livelihoods on individual and community level. It includes human, social, natural, physical and financial aspects and the role of institutions, policies and legal rights in reducing or increasing exposure to disaster risk and coping capacities. Additionally, theories on risk perception, especially Protection-Motivation Theory, developed by social sciences, will be used as assessment frame to understand people`s flood damage mitigation behaviour. Furthermore, spatial theories and landscape planning approaches (like an everyday, evidence-based approach) are combined with theories from social sciences reflecting the interdisciplinary approach of this project that has become standard in studies on disaster and climate change. This theoretical approach was developed through a collaborative research at the beginning of the research design in order to a) develop further and test existing concepts, b) to fine-tune the proposed method setting, c) to foster common understanding of theories and methods within the interdisciplinary research team. In general, the research process is characterised by critical theory and brings in reflective elements, allowing feedback circles between methods and theories. End-users and decision-makers will be integral partners, ensuring that feasibility of the recommendations and guidelines will be guaranteed. Consequently, the methods of data collection in this project reflect the results of the critical discussion of the theoretical frameworks and combine methods of social sciences: interviews with inhabitants living in hazard zones, detailed surveys of families, focus group discussions, and expert interviews with local and regional stakeholders involved in disaster risk management. In addition to that, structural factors, demographic data, current risk communication strategies, legal instruments and related processes and the current spatial and environmental situation (including hazards and hazard zones, geographical locations, building and settlement types) are analysed.

76 FR 34639 - Notice of Proposed Additional Information Collection: Advisory Committee and Research and...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-14

... and Research and Promotion Background Information AGENCY: Office of the Secretary, USDA. ACTION... and Promotion Background Information to include Race, Ethnicity, National Origin, Gender and...: [email protected] . SUPPLEMENTARY INFORMATION: Title: Advisory Committee and Research and Promotion...

Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies: An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project.

PubMed

Calderon, M A; Demoly, P; Casale, T; Akdis, C A; Bachert, C; Bewick, M; Bilò, B M; Bohle, B; Bonini, S; Bush, A; Caimmi, D P; Canonica, G W; Cardona, V; Chiriac, A M; Cox, L; Custovic, A; De Blay, F; Devillier, P; Didier, A; Di Lorenzo, G; Du Toit, G; Durham, S R; Eng, P; Fiocchi, A; Fox, A T; van Wijk, R Gerth; Gomez, R M; Haathela, T; Halken, S; Hellings, P W; Jacobsen, L; Just, J; Tanno, L K; Kleine-Tebbe, J; Klimek, L; Knol, E F; Kuna, P; Larenas-Linnemann, D E; Linneberg, A; Matricardi, M; Malling, H J; Moesges, R; Mullol, J; Muraro, A; Papadopoulos, N; Passalacqua, G; Pastorello, E; Pfaar, O; Price, D; Del Rio, P Rodriguez; Ruëff, R; Samolinski, B; Scadding, G K; Senti, G; Shamji, M H; Sheikh, A; Sisul, J C; Sole, D; Sturm, G J; Tabar, A; Van Ree, R; Ventura, M T; Vidal, C; Varga, E M; Worm, M; Zuberbier, T; Bousquet, J

2016-01-01

Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing.

The Impact of Re-tear on the Clinical Outcome after Rotator Cuff Repair Using Open or Arthroscopic Techniques – A Systematic Review

PubMed Central

Galanopoulos, Ilias; Ilias, Aslanidis; Karliaftis, Konstantinos; Papadopoulos, Dimitrios; Ashwood, Neil

2017-01-01

Background: It is generally accepted that rotator cuff repair gives satisfactory results in the long term, although most studies have so far shown a fairly high rate of structural failure or re-tear. The purpose of this review study is to assess whether failure of the repaired cuff to heal could negatively affect the functional outcome. Methods: This article includes an extensive Internet PubMed based research in the current English-language literature including level I to level V studies as well as systematic reviews. Results: According to this extended study research, the results are mixed; certain reports show that patients with a healed rotator cuff repair have improved function and strength compared to those with structural failure, whereas other studies support the generally perceived concept that tendon re-tear does not lead to inferior clinical outcome. Conclusion: Further high-level prospective studies with larger numbers of patients and longer follow up are needed to overcome the current debate over function between healed and failed rotator cuff repairs. PMID:28400878

Psychological Intimate Partner Violence and Sexual Risk Behavior: Examining the Role of Distinct PTSD Symptoms in the Partner Violence-sexual Risk Link

PubMed Central

Overstreet, Nicole M.; Willie, Tiara C.; Hellmuth, Julianne C.; Sullivan, Tami P.

2014-01-01

BACKGROUND Research has examined how physical and sexual intimate partner violence (IPV) victimization increases sexual risk behavior, yet research is lacking on 1) the effect of psychological IPV on sexual risk behavior and 2) factors through which psychological IPV may be linked to sexual risk behavior. METHODS The current study examined the relationship between psychological IPV and sexual risk behavior controlling for other forms of IPV (i.e., physical and sexual) in a sample of 186 HIV-negative community women currently experiencing IPV. Further, this study examined the potential mediating effects of four posttraumatic stress disorder (PTSD) symptom severity clusters (i.e., re-experiencing, avoidance, numbing, and hyperarousal) on this relationship. FINDINGS Results revealed that greater severity of psychological IPV was uniquely and directly related to greater sexual risk behavior. Additionally, of the four PTSD symptom severity clusters, only avoidance symptom severity mediated the relationship between psychological IPV and sexual risk behavior. CONCLUSION Implications for addressing psychological IPV and PTSD to improve women’s sexual health outcomes are discussed. PMID:25498762

Challenges facing translational research organizations in China: a qualitative multiple case study

PubMed Central

2013-01-01

Background Translational medicine is attracting much attention worldwide and many translational research organizations (TROs) have been established. In China, translational medicine has developed rapidly, but faces many challenges. This study was aimed at exploring these challenges faced by emerging TROs in China. Method A qualitative, multiple case study approach was used to assess the challenges faced by TROs in China. Data were collected between May and August 2012. Results Eight cases were identified. Overall, four themes that characterized TROs in China emerged from analyses: 1. objectives, organizer, and funding resources, 2. participating partners and research teams, 3. management, and 4. achievements. All TROs had objectives related to translating basic discovery to clinic treatment and cultivating translational researchers. In terms of organizer and funding resources, 7 out of 8 TROs were launched only by universities and/or hospitals, and funded mostly through research grants. As for participating partners and multidisciplinary research teams, all but one of the TROs only involved biomedical research institutions who were interested in translational research, and characterized as clinical research centers; 7 out of 8 TROs involved only researchers from biomedicine and clinical disciplines and none involved disciplines related to education, ethnicity, and sociology, or engaged the community. Current management of the TROs were generally nested within the traditional research management paradigms, and failed to adapt to the tenets of translational research. Half of the TROs were at developmental stages defined as infrastructure construction and recruitment of translational researchers. Conclusions TROs in China face the challenge of attracting sustainable funding sources, widening multidisciplinary cooperation, cultivating multi-disciplinary translational researchers and adapting current research management to translational research. Greater emphasis should be placed on increasing multidisciplinary cooperation, and innovating in education programs to cultivate of translational researchers. Efforts should be made to reform research management in TROs, and establish sustainable funding resources. PMID:24119837

Postdoctoral Fellow | Center for Cancer Research

Cancer.gov

The Neural Development Section (NDS) headed by Dr. Lino Tessarollo has an open postdoctoral fellow position. The candidate should have a background in neurobiology and basic expertise in molecular biology, cell biology, immunoistochemistry and biochemistry.  Experience in confocal analysis is desired. The NDS study the biology of neurotrophin and Trk receptors function by using both in vitro and in vivo approaches. Our group makes extensive use of engineered mouse models and cell culture models. The current research emphasis is on understanding the molecular mechanisms by which activated trk receptor function. Specifically, we are dissecting the molecular mechanism responsible for modulating Trk receptors activity, including their interaction with specific scaffold proteins and proteins leading to de-activation of Trk signaling. Moreover, we are attempting to identify new signaling pathways activated by truncated Trk receptors.

Patterns of mental health service utilization.

PubMed

Howard, K I; Cornille, T A; Lyons, J S; Vessey, J T; Lueger, R J; Saunders, S M

1996-08-01

How many and which individuals, with which psychiatric disorders, receive (and do not receive) mental health services from which professionals in what settings? This question falls within the purview of mental health services research, which is a multidisciplinary field that brings together the methodologies of epidemiology, econometrics, and clinical research. First, in this article, we present an explication of what is known about those individuals in need of psychotherapy and how they access services. Next, we describe the numbers, professional affiliations, and service sites of professionals who are engaged in the practice of psychotherapy. We summarize our current knowledge about the actual utilization of psychotherapy services relative to the needs of patients and the professional background of therapists. Finally, we identify aspects of psychotherapy service utilization that are, as yet, unaddressed.

Status Update Report for the Peregrine 100km Sounding Rocket Project

NASA Technical Reports Server (NTRS)

Dyer, Jonny; Zilliac, Greg; Doran, Eric; Marzona, Mark Thadeus; Lohner, Kevin; Karlik, Evan; Cantwell, Brian; Karabeyoglu, Arif

2008-01-01

The Peregrine Sounding Rocket Program is a joint basic research program of NASA Ames Research Center, NASA Wallops, Stanford University and the Space Propulsion Group, Inc. (SPG). The goal is to determine the applicability of liquifying hybrid technology to a small launch system. The approach is to design, build, test and y a stable, efficient liquefying fuel hybrid rocket vehicle to an altitude of 100 km. The program was kicked o in October of 2006 and has seen considerable progress in the subsequent 18 months. Two virtually identical vehicles will be constructed and own out of the NASA Sounding Rocket Facility at Wallops Island. This paper presents the current status of the project as of June 2008. For background on the project, the reader is referred to last year's paper.

[Max Weber's disease. Research on the disease and therapeutic management at the turn of the century].

PubMed

Frommer, J; Frommer, S

1998-05-01

This article on the German economist and sociologist Max Weber (1864-1920) continues our pathographic and psychohistoric studies on the interrelations between his life, his illness, and his work on "Protestantic Ethics and the Spirit of Capitalism". In a former paper (Frommer u. Frommer, 1993) we focussed on Weber's definition of modern society as an "iron cage" determined by Western rationalism. His theory, which shows that this cultural background demands a great amount of role conformity from the individual, converges with current psychopathological approaches on the personality of depressed patients. In the second article we report on results of our research on further personal documents, and some medical certificates by Weber's physicians. These documents demonstrate the diagnosis of a severe depression in a narcisstic and hypernomic personality.

PREP inside and out: marriage education for inmates.

PubMed

Einhorn, Lindsey; Williams, Tamara; Stanley, Scott; Wunderlin, Nicole; Markman, Howard; Eason, Joanne

2008-09-01

Although research has demonstrated that marriage education has positive effects on relationship quality, little is known about how such services impact relationships where one partner is incarcerated. The current study implemented an adapted version of the Prevention and Relationship Enhancement Program (PREP Inside and Out) for inmates in Oklahoma correctional facilities. Inmates, with or without their partners, participated in the 12-hour program. The impact of the program was investigated on a range of relationship variables including satisfaction with relationship, dedication, confidence, communication skills, friendship, and negative interactions as reported by the inmate partner. Participants reported substantial gains in all variables and in overall satisfaction with their relationship after completing the program, regardless of their gender and racial/ethnic background. Implications for future marriage education programs and research in prisons are discussed.

The Spartan-281 Far Ultraviolet Imaging Spectrograph

NASA Technical Reports Server (NTRS)

Carruthers, George R.; Heckathorn, Harry M.; Dufour, Reginald J.; Opal, Chet B.; Raymond, John C.

1988-01-01

The U.S. Naval Research Laboratory's Far Ultraviolet Imaging Spectrograph (FUVIS), currently under development for flight as a Spartan shuttle payload, is designed to perform spectroscopy of diffuse sources in the FUV with very high sensitivity and moderate spatial and spectral resolution. Diffuse nebulae, the general galactic background radiation, and artificially induced radiation associated with the Space Shuttle vehicle are sources of particular interest. The FUVIS instrument will cover the wavelength range of 970-2000 A with selectable resolutions of 5 and 30 A. It is a slit imaging spectrograph having 3 arcmin spatial resolution along its 2.7 deg long slit.

Headed reinforcement in concrete structure: State of the art

NASA Astrophysics Data System (ADS)

Alrasyid, Harun; Yoganata, Yehezkiel Septian; Suluch, Munarus; Iranata, Data

2017-11-01

At the reinforced concrete structure, the utilization of the headed bar has provided simpler installation, less congestion of reinforcement and more effective anchorage compared to conventional reinforcing bars anchorage by hooks and bends. A literature review related to the use of headed reinforcement are exhibited. The paper discusses the behavior anchorage of headed reinforcement, and the application of at beam column joint and as shear reinforcement. The review of headed bar includes historical background, the available commercial product and the summary of the experimental results that uses this application. Based on current study the suggestion for further research are provided.

Recent Advances and Challenges towards Sustainable Polyhydroxyalkanoate (PHA) Production.

PubMed

Kourmentza, Constantina; Plácido, Jersson; Venetsaneas, Nikolaos; Burniol-Figols, Anna; Varrone, Cristiano; Gavala, Hariklia N; Reis, Maria A M

2017-06-11

Sustainable biofuels, biomaterials, and fine chemicals production is a critical matter that research teams around the globe are focusing on nowadays. Polyhydroxyalkanoates represent one of the biomaterials of the future due to their physicochemical properties, biodegradability, and biocompatibility. Designing efficient and economic bioprocesses, combined with the respective social and environmental benefits, has brought together scientists from different backgrounds highlighting the multidisciplinary character of such a venture. In the current review, challenges and opportunities regarding polyhydroxyalkanoate production are presented and discussed, covering key steps of their overall production process by applying pure and mixed culture biotechnology, from raw bioprocess development to downstream processing.

United States/Russia space cooperation documentary

NASA Astrophysics Data System (ADS)

1993-12-01

This video documents the initiative to develop a multinational, permanent space research laboratory. Historical background on the U.S. and Soviet manned space flight program as well as joint efforts such as the Apollo-Soyuz link up is shown. The current initiative will begin with collaborative missions involving NASA's space shuttle and Russia's Mir space station, and culminate in a permanently manned space station involving the U.S., Russia, Japan, Canada, and ESA. Shown are computer simulations of the proposed space station. Commentary is provided by the NASA administrator, former astronauts, cosmonauts, and Russian and American space experts.

National Athletic Trainers' Association Position Statement: Management of Sport Concussion

PubMed Central

Broglio, Steven P.; Cantu, Robert C.; Gioia, Gerard A.; Guskiewicz, Kevin M.; Kutcher, Jeffrey; Palm, Michael; McLeod, Tamara C. Valovich

2014-01-01

Objective: To provide athletic trainers, physicians, and other health care professionals with best-practice guidelines for the management of sport-related concussions. Background: An estimated 3.8 million concussions occur each year in the United States as a result of sport and physical activity. Athletic trainers are commonly the first medical providers available onsite to identify and evaluate these injuries. Recommendations: The recommendations for concussion management provided here are based on the most current research and divided into sections on education and prevention, documentation and legal aspects, evaluation and return to play, and other considerations. PMID:24601910

Year in review 2009: Critical Care--infection.

PubMed

Harbarth, Stephan; Haustein, Thomas

2010-01-01

In 2009 Critical Care provided important and clinically relevant research data for management and prevention of infections in critically ill patients. The present review summarises the results of these observational studies and clinical trials and discusses them in the context of the current relevant scientific and clinical background. In particular, we discuss recent epidemiologic data on nosocomial infections in intensive care units, present new approaches to prevention of ventilator-associated pneumonia, describe recent advances in biomarker-guided antibiotic stewardship and attempt to briefly summarise specific challenges related to the management of infections caused by multidrug-resistant microorganisms and influenza A (H1N1).

United States/Russia Space Cooperation Documentary

NASA Technical Reports Server (NTRS)

1993-01-01

This video documents the initiative to develop a multinational, permanent space research laboratory. Historical background on the U.S. and Soviet manned space flight program as well as joint efforts such as the Apollo-Soyuz link up is shown. The current initiative will begin with collaborative missions involving NASA's space shuttle and Russia's Mir space station, and culminate in a permanently manned space station involving the U.S., Russia, Japan, Canada, and ESA. Shown are computer simulations of the proposed space station. Commentary is provided by the NASA administrator, former astronauts, cosmonauts, and Russian and American space experts.

Collective-Intelligence Recommender Systems: Advancing Computer Tailoring for Health Behavior Change Into the 21st Century

PubMed Central

Cutrona, Sarah L; Kinney, Rebecca L; Marlin, Benjamin M; Mazor, Kathleen M; Lemon, Stephenie C; Houston, Thomas K

2016-01-01

Background What is the next frontier for computer-tailored health communication (CTHC) research? In current CTHC systems, study designers who have expertise in behavioral theory and mapping theory into CTHC systems select the variables and develop the rules that specify how the content should be tailored, based on their knowledge of the targeted population, the literature, and health behavior theories. In collective-intelligence recommender systems (hereafter recommender systems) used by Web 2.0 companies (eg, Netflix and Amazon), machine learning algorithms combine user profiles and continuous feedback ratings of content (from themselves and other users) to empirically tailor content. Augmenting current theory-based CTHC with empirical recommender systems could be evaluated as the next frontier for CTHC. Objective The objective of our study was to uncover barriers and challenges to using recommender systems in health promotion. Methods We conducted a focused literature review, interviewed subject experts (n=8), and synthesized the results. Results We describe (1) limitations of current CTHC systems, (2) advantages of incorporating recommender systems to move CTHC forward, and (3) challenges to incorporating recommender systems into CTHC. Based on the evidence presented, we propose a future research agenda for CTHC systems. Conclusions We promote discussion of ways to move CTHC into the 21st century by incorporation of recommender systems. PMID:26952574

RE-DEFINING THE ROLES OF SENSORS IN OBJECTIVE PHYSICAL ACTIVITY MONITORING

PubMed Central

Chen, Kong Y.; Janz, Kathleen F.; Zhu, Weimo; Brychta, Robert J.

2011-01-01

Background As physical activity researchers are increasingly using objective portable devices, this review describes current state of the technology to assess physical activity, with a focus on specific sensors and sensor properties currently used in monitors and their strengths and weakness. Additional sensors and sensor properties desirable for activity measurement and best practices for users and developers also are discussed. Best Practices We grouped current sensors into three broad categories for objectively measuring physical activity: associated body movement, physiology, and context. Desirable sensor properties for measuring physical activity and the importance of these properties in relationship to specific applications are addressed, and the specific roles of transducers and data acquisition systems within the monitoring devices are defined. Technical advancements in sensors, microcomputer processors, memory storage, batteries, wireless communication, and digital filters have made monitors more usable for subjects (smaller, more stable, and longer running time) and for researchers (less costly, higher time resolution and memory storage, shorter download time, and user-defined data features). Future Directions Users and developers of physical activity monitors should learn about the basic properties of their sensors, such as range, accuracy, precision, while considering the data acquisition/filtering steps that may be critical to data quality and may influence the desirable measurement outcome(s). PMID:22157770

Observation of increased space-charge limited thermionic electron emission current by neutral gas ionization in a weakly-ionized deuterium plasma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hollmann, E. M.; Yu, J. H.; Doerner, R. P.

2015-09-14

The thermionic electron emission current emitted from a laser-produced hot spot on a tungsten target in weakly-ionized deuterium plasma is measured. It is found to be one to two orders of magnitude larger than expected for bipolar space charge limited thermionic emission current assuming an unperturbed background plasma. This difference is attributed to the plasma being modified by ionization of background neutrals by the emitted electrons. This result indicates that the allowable level of emitted thermionic electron current can be significantly enhanced in weakly-ionized plasmas due to the presence of large neutral densities.

Magnetospheric Reconnection in Modified Current-Sheet Equilibria

NASA Astrophysics Data System (ADS)

Newman, D. L.; Goldman, M. V.; Lapenta, G.; Markidis, S.

2012-10-01

Particle simulations of magnetic reconnection in Earth's magnetosphere are frequently initialized with a current-carrying Harris equilibrium superposed on a current-free uniform background plasma. The Harris equilibrium satisfies local charge neutrality, but requires that the sheet current be dominated by the hotter species -- often the ions in Earth's magnetosphere. This constraint is not necessarily consistent with observations. A modified kinetic equilibrium that relaxes this constraint on the currents was proposed by Yamada et al. [Phys. Plasmas., 7, 1781 (2000)] with no background population. These modified equilibria were characterized by an asymptotic converging or diverging electrostatic field normal to the current sheet. By reintroducing the background plasma, we have developed new families of equilibria where the asymptotic fields are suppressed by Debye shielding. Because the electrostatic potential profiles of these new equilibria contain wells and/or barriers capable of spatially isolating different populations of electrons and/or ions, these solutions can be further generalized to include classes of asymmetric kinetic equilibria. Examples of both symmetric and asymmetric equilibria will be presented. The dynamical evolution of these equilibria, when perturbed, will be further explored by means of implicit 2D PIC reconnection simulations, including comparisons with simulations employing standard Harris-equilibrium initializations.

The role of consent in medical research: breaking or building walls? A call for legislative reform.

PubMed

Dangata, Yohanna Yanshiyi

2011-12-01

Research has been integral to the practice of medicine for almost as long as the discipline has existed. Until fairly recently research used to be conducted on human subjects without mandatory requirement for their consent. However, over time medical research became associated with significant cruelty resulting in an outcry for regulation of research actives. This resulted in significant legislation in place for monitoring. Today it is mandatory to obtain consent from subjects before embarking on medical research, and indeed treatment. Its significant regulatory role notwithstanding, the issue of consent at times becomes a hindrance to research. This paper examines the issue of consent in relation to medical research in the context of present legislation. It lays out the background to medical research with respect to purpose, scope, standard protocol and related issues; it then addresses the issue of consent in various scenarios, highlighting problems and the need for legislative reform. It is maintained that while regulatory measures have brought a lot of sanity to medical research and the medical profession, some measures are building walls inhibitory to research activities. Research being integral to the development and growth of healthcare delivery, there is need for reformation of current medical law for balance between patient protectionism and progress in medical research for effective patient care.

Learning to Lead in Higher Education: Insights into the Family Backgrounds of Women University Presidents

ERIC Educational Resources Information Center

Madsen, Susan R.

2007-01-01

The purpose of the study was to explore the lived experiences of women university presidents related to becoming leaders or learning to lead. This manuscript highlights the research focused on the immediate family backgrounds and influences on these presidents. The research question was as follows: With regard to their family backgrounds and…

Patterns of Food Parenting Practices and Children's Intake of Energy-Dense Snack Foods.

PubMed

Gevers, Dorus W M; Kremers, Stef P J; de Vries, Nanne K; van Assema, Patricia

2015-05-27

Most previous studies of parental influences on children's diets included just a single or a few types of food parenting practices, while parents actually employ multiple types of practices. Our objective was to investigate the clustering of parents regarding food parenting practices and to characterize the clusters in terms of background characteristics and children's intake of energy-dense snack foods. A sample of Dutch parents of children aged 4-12 was recruited by a research agency to fill out an online questionnaire. A hierarchical cluster analysis (n = 888) was performed, followed by k-means clustering. ANOVAs, ANCOVAs and chi-square tests were used to investigate associations between cluster membership, parental and child background characteristics, as well as children's intake of energy-dense snack foods. Four distinct patterns were discovered: "high covert control and rewarding", "low covert control and non-rewarding", "high involvement and supportive" and "low involvement and indulgent". The "high involvement and supportive" cluster was found to be most favorable in terms of children's intake. Several background factors characterized cluster membership. This study expands the current knowledge about parental influences on children's diets. Interventions should focus on increasing parental involvement in food parenting.

Analysis of selected volatile organic compounds at background level in South Africa.

NASA Astrophysics Data System (ADS)

Ntsasa, Napo; Tshilongo, James; Lekoto, Goitsemang

2017-04-01

Volatile organic compounds (VOC) are measured globally at urban air pollution monitoring and background level at specific locations such as the Cape Point station. The urban pollution monitoring is legislated at government level; however, the background levels are scientific outputs of the World Meteorological Organisation Global Atmospheric Watch program (WMO/GAW). The Cape Point is a key station in the Southern Hemisphere which monitors greenhouse gases and halocarbons, with reported for over the past decade. The Cape Point station does not have the measurement capability VOC's currently. A joint research between the Cape Point station and the National Metrology Institute of South Africa (NMISA) objective is to perform qualitative and quantitative analysis of volatile organic compounds listed in the GAW program. NMISA is responsible for development, maintain and disseminate primary reference gas mixtures which are directly traceable to the International System of Units (SI) The results of some volatile organic compounds which where sampled in high pressure gas cylinders will be presented. The analysis of samples was performed on the gas chromatography with flame ionisation detector and mass selective detector (GC-FID/MSD) with a dedicate cryogenic pre-concentrator system. Keywords: volatile organic compounds, gas chromatography, pre-concentrator

Lessons in collaboration and effective field research from the Appalachian Headwaters Research Experience for Undergraduates Program

NASA Astrophysics Data System (ADS)

Jones, A. L.; Fox, J.; Wilder, M. S.

2009-12-01

In the summer of 2009, the authors launched year one of a three-year National Science Foundation-funded Research Experience for Undergraduates entitled "Carbon Storage and Headwater Health in the Appalachian Headwaters." Eight undergraduates selected from a nationally competitive field of more than 60 applicants participated in the ten-week field- and laboratory-based program along with three middle- and high-school teachers. Each student developed and completed an independent research project related to coal mining’s impact on soil organic carbon and sediment transport processes. Specifically, they used isotope ratio mass spectrometry to measure the carbon and nitrogen stable isotopic signature of soils and sediments in the Appalachian headwater landscapes and first order streams of Kentucky's southeastern coalfields. Among the program's innovative features was its fundamentally collaborative nature--which was represented in several ways. First, the background of the three program leaders was very different: an environmental planner with an academic background in land use planning and administration (Jones); a civil engineer trained in biogeochemistry and watershed modeling (Fox); and an environmental educator experienced in both formal and nonformal educator training and certification (Wilder). The program was also a collaboration between a Carnegie 1 research-oriented institution and an undergraduate/ teaching -focused regional comprehensive university. Finally, the participants themselves represented a diversity of disciplines and institutional backgrounds--including biology, geology, chemistry, environmental science and civil engineering. The Research Experience for Teachers component was another innovative program element. The teachers participated in all field and laboratory research activities during the first six weeks, then developed a unit of study for their own classrooms to be implemented during the current school year. In addition to the six overnight fieldwork trips into the forests and coalfields of Appalachia, two “fun day” field trips were built into the program specifically for team-building and camaraderie. Participant evaluations were overwhelmingly positive, and in particular, students indicated they gained a better understanding and appreciation of the scientific research process, and a greater understanding of relationship between their own disciplines and other related fields. The summer was not without challenges and “incidents”, which ranged from minor miscommunications over field logistics and bureaucratic disconnects between the two universities, to a major instrument breakdown at the lab that was to process the samples. But overall, the research objectives were accomplished, and the program represented a successful collaborative field-based undergraduate research experience.

Federal Child Care Policy. Current and Proposed. Family Impact Seminar (Washington, D.C., April 28, 1989). Meeting Highlights and Background Briefing Report.

ERIC Educational Resources Information Center

Ooms, Theodora; Herendeen, Lisa

The purpose of this policy seminar, one of a series of family impact seminars, was to consider current and proposed policies of the federal government that concern child care. This document provides highlights of presentations by the seminar panelists and a background briefing report prepared before the meeting. The highlights section summarizes:…

Feminist identity among women and men from four ethnic groups.

PubMed

Robnett, Rachael D; Anderson, Kristin J

2017-01-01

Multiracial feminist theory proposes that the meaning of feminism and the pathways to feminist identity may differ on the basis of cross-cutting social categories such as ethnicity and gender. However, there is currently little research that has included systematic examination of feminist identity among women and men from diverse ethnic backgrounds. We examined feminist orientations among 1,140 undergraduates (70% women) at a Hispanic-Serving Institution who identified as African American, Asian American, European American, or Latina/o. Three related research aims were assessed through a combination of closed- and open-ended questions. First, we examined whether the meaning of the term feminism differed depending on participants' ethnicity or gender. We then tested for ethnic and gender variation in rates of feminist identity. Lastly, we examined participants' reasons for either identifying or not identifying as feminists. Ethnic and gender differences were obtained across each of the 3 research aims. For example, there were significant ethnic differences in rates of feminist identity among women, but not among men. Relative to past research, through the current study, we have provided an especially comprehensive examination of how ethnicity and gender interact to shape feminist attitudes. Consistent with multiracial feminist theory, findings demonstrated that attitudes about feminism vary as a function of both gender and ethnicity, yet key ethnic and gender similarities also emerged. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Examining leadership as a strategy to enhance health care service delivery in regional hospitals in South Africa

PubMed Central

Govender, Sagaren; Gerwel Proches, Cecile N; Kader, Abdulla

2018-01-01

Background Four public hospitals in South Africa, which render both specialized and nonspecialized services to thousands of patients, were examined to determine the impact of leadership on health care service delivery. These hospitals were inundated by various problems that were impacting negatively on health care service delivery. Purpose This research study aimed to gain a comprehensive understanding of the challenges, complexities and constraints facing public health care in KwaZulu-Natal (KZN) and to examine leadership as a strategy to enhance healthcare service delivery with a particular focus on four regional hospitals in the KZN Province. Methods The mixed-method research approach was utilized. Purposive sampling and stratified random sampling were employed in the research setting, and in-depth, semistructured interviews and questionnaires were used to collect data. Data were analyzed using the Nvivo computer software package for in-depth interviews and the Statistical Package for the Social Sciences (SPSS) software for the quantitative analysis. Results The research findings showed that the current leadership framework adopted by the health care leaders in regional hospitals in KZN is weak and is contributing to poor health care service delivery. Conclusion This study, therefore, aimed to address the current challenges and weaknesses that are impacting negatively on health care service delivery in regional hospitals in the KZN Province and made recommendations for improvement. PMID:29535529

[HLA-B27 Positive Acute Anterior Uveitis - A Translational Perspective].

PubMed

Heiligenhaus, Arnd; Kasper, Maren; Grajewski, Rafael

2017-05-01

Background HLA-B27 positive acute anterior uveitis is the most common type of uveitis, and it is an autoimmune disease that can be triggered by infections. The precise mechanism of the interaction between involved microbes (mostly gram negative bacteria) and the host immune system is not clear. The disease probably results from an imbalance between pro- and anti-inflammatory components. Project description This article gives a compact overview about the current knowledge of the clinic and the etiopathogenesis of acute anterior uveitis as a basis for future research approaches. The goal of the current research is to classify the cellular and molecular pathogenetic factors in acute anterior uveitis. In this regard, a project on uveitis within the clinical research unit FOR 2240 "(Lymph)Angiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye", examines the hypothesis that dysregulation of regulatory cell populations and anti-inflammatory cytokines, such as interleukin-10 (IL-10), might contribute to the development of ocular autoimmunity following infections. The goal is to establish new markers for individual susceptibility in the risk group of the HLA-B27 positive population, because only about 1% of the HLA-B27 positive population will eventually develop acute anterior uveitis. Conclusions Translational research approaches to identify predisposed risk groups from the HLA-B27 population could improve patient care both on a prophylactic and a therapeutic level. Georg Thieme Verlag KG Stuttgart · New York.

Eliciting and utilizing rural students' funds of knowledge in the service of science learning: An action research study

NASA Astrophysics Data System (ADS)

Lloyd, Ellen M.

Several researchers have pointed out the failures of current schooling to adequately prepare students in science and called for radical reform in science education to address the problem. One dominant critique of science education is that several groups of students are not well served by current school science practices and discourses. Rural students represent one of these underserved populations. Yet, there is little in the literature that speaks specifically to reforming the science education of rural students. Utilizing action research as a methodology, this study was designed to learn more about the unique knowledge and life experiences of rural students, and how these unique knowledge, skills and interests could suggest new ways to improve science education in rural schools. Informed by this ultimate goal, I created an after school science club where the participating high school students engaged in solving a local watershed problem, while explicitly bringing to bear their unique backgrounds, local knowledge and life experiences from living in a rural area of Upstate New York. Using Funds of Knowledge as the theoretical framework, this after-school club served as the context to investigate the following research questions: (1) What science-related funds of knowledge do rural high school students have? (2) How were these funds of knowledge capitalized on to support science learning in an after-school setting?

Tracking the Current Rise of Chinese Pharmaceutical Bionanotechnology

PubMed Central

Lenoir, Tim; Herron, Patrick

2009-01-01

ABSTRACT Background: The Context and Purpose of the Study Over the last decade China has emerged as a major producer of scientific publications, currently ranking second behind the US. During that time Chinese strategic policy initiatives have placed indigenous innovation at the heart of its economy while focusing internal R&D investments and the attraction of foreign investment in nanotechnology as one of their four top areas. China’s scientific research publication and nanotechnology research publication production has reached a rank of second in the world, behind only the US. Despite these impressive gains, some scholars argue that the quality of Chinese nanotech research is inferior to US research quality due to lower overall times cited rates, suggesting that the US is still the world leader. We combine citation analysis, text mining, mapping, and data visualization to gauge the development and application of nanotechnology in China, particularly in biopharmananotechnology, and to measure the impact of Chinese policy on nanotechnology research production. Results, the main findings Our text mining-based methods provide results that counter existing claims about Chinese nanotechnology research quality. Due in large part to its strategic innovation policy, China’s output of nanotechnology publications is on pace to surpass US production in or around 2012.A closer look at Chinese nanotechnology research literature reveals a large increase in research activity in China’s biopharmananotechnology research since the implementation in January, 2006 of China’s Medium & Long Term Scientific and Technological Development Plan Guidelines for the period 2006-2020 (“MLP”). Since the implementation of the MLP, China has enjoyed a great deal of success producing bionano research findings while attracting a great deal of foreign investment from pharmaceutical corporations setting up advanced drug discovery operations. Given the combination of current scientific production growth as well as economic growth, a relatively low scientific capacity, and the ability of its policy to enhance such trends, China is in some sense already the new world leader in nanotechnology. Further, the Chinese national innovation system may be the new standard by which other national S&T policies should be measured. PMID:19838996

Update to Permeable Pavement Research at the Edison ...

EPA Pesticide Factsheets

Brief Background of Edison Environmental Center in Edison, New Jersey Porous Pavement research at the Edison Environmental Center in Edison, New Jersey Publications and references Brief Background of Edison Environmental Center in Edison, New Jersey Porous Pavement research at the Edison Environmental Center in Edison, New Jersey

Understanding the Research–Policy Divide for Oral Health Inequality

PubMed Central

Bell, Erica; Crocombe, Leonard; Campbell, Steven; Goldberg, Lynette R.; Seidel, Bastian M.

2014-01-01

Background: No studies exist of the congruence of research in oral health to policy. This study aimed to examine the broad congruence of oral health research to policy, and implications for developing oral health research that is more policy relevant, particularly for the wider challenge of addressing unequal oral health outcomes, rather than specific policy translation issues. Methods: Bayesian-based software was used in a multi-layered method to compare the conceptual content of 127,193 oral health research abstracts published between 2000–2012 with eight current oral health policy documents from Organisation for Economic Co-operation and Development countries. Findings: Fifty-five concepts defined the research abstracts, of which only eight were policy-relevant, and six of which were minor research concepts. Conclusions The degree of disconnection between clinical concepts and healthcare system and workforce development concepts was striking. This study shows that, far from being “lost in translation,” oral health research and policy are so different as to raise doubts about the extent to which research is policy-relevant and policy is research-based. The notion of policy relevance encompasses the lack of willingness of policy makers to embrace research, and the need for researchers to develop research that is, and is seen to be, policy-relevant. PMID:25617516

An operational amplifier B1404UD1A-1 in the patch-clamp current-to-voltage converter.

PubMed

Korzun, A M; Rozinov, S V; Abashin, G I

1997-01-01

The applicability of the home-made operational amplifier B1404UD1A-1 in a patch-clamp current-to-voltage converter was analyzed. Its parameters (background noise, input bias current, and gain-bandwidth product) were estimated. Schematic solutions and practical recommendations for the use of this amplifier in a current-to-voltage converter were given. Based on the background noise and frequency parameters of the converter, we found that this device can be used for measuring ion channel currents with a high sensitivity and within a broad frequency range (0.055 pA, to 1 kHz; 0.4 pA, to 10 kHz). An example of the converter application in experiments is given.

General Aviation in Nebraska: Nebraska SATS Project Background Paper No. 1

NASA Technical Reports Server (NTRS)

Smith, Russell; Wachal, Jocelyn

2000-01-01

The Nebraska SATS project is a state-level component of NASA's Small Aircraft Transportation System (SATS). During the next several years the project will examine several different factors affecting SATS implementation in Nebraska. These include economic and taxation issues, public policy issues, airport planning processes, information dissemination strategies, and systemic change factors. This background paper profiles the general aviation system in Nebraska. It is written to provide information about the "context" within which SATS will be pursued. The primary focus is thus on describing and providing background information about the current situation. A secondary focus is on drawing general conclusions about the ability of the current system to incorporate the types of changes implied by SATS. First, some brief information on the U.S. aviation system is provided. The next two sections profile the current general aviation aircraft and pilot base. Nebraska's system of general aviation airports is then described. Within this section of the paper, information is provided on the different types of general aviation airports in Nebraska, airport activity levels and current infrastructure. The fourth major section of the background paper looks at Nebraska's local airport authorities. These special purpose local governments oversee the majority of the general aviation airports in the state. Among the items examined are total expenditures, capital expenditures and planning activities. Next, the paper provides background information on the Nebraska Department of Aeronautics (NDA) and recent Federal funding for general aviation in Nebraska. The final section presents summary conclusions.

National Heart, Lung, and Blood Institute Workshop Summary: Enhancing Opportunities for Training and Retention of a Diverse Biomedical Workforce.

PubMed

Duncan, Gregg A; Lockett, Angelia; Villegas, Leah R; Almodovar, Sharilyn; Gomez, Jose L; Flores, Sonia C; Wilkes, David S; Tigno, Xenia T

2016-04-01

Committed to its mission of conducting and supporting research that addresses the health needs of all sectors of the nation's population, the Division of Lung Diseases, National Heart, Lung, and Blood Institute of the National Institutes of Health (NHLBI/NIH) seeks to identify issues that impact the training and retention of underrepresented individuals in the biomedical research workforce. Early-stage investigators who received grant support through the NIH Research Supplements to Promote Diversity in Health Related Research Program were invited to a workshop held in Bethesda, Maryland in June, 2015, in order to (1) assess the effectiveness of the current NHLBI diversity program, (2) improve its strategies towards achieving its goal, and (3) provide guidance to assist the transition of diversity supplement recipients to independent NIH grant support. Workshop participants participated in five independent focus groups to discuss specific topics affecting underrepresented individuals in the biomedical sciences: (1) Socioeconomic barriers to success for diverse research scientists; (2) role of the academic research community in promoting diversity; (3) life beyond a research project grant: non-primary investigator career paths in research; (4) facilitating career development of diverse independent research scientists through NHLBI diversity programs; and (5) effectiveness of current NHLBI programs for promoting diversity of the biomedical workforce. Several key issues experienced by young, underrepresented biomedical scientists were identified, and solutions were proposed to improve on training and career development for diverse students, from the high school to postdoctoral trainee level, and address limitations of currently available diversity programs. Although some of the challenges mentioned, such as cost of living, limited parental leave, and insecure extramural funding, are also likely faced by nonminority scientists, these issues are magnified among diversity scientists and are complicated by unique circumstances in this group, such as limited exposure to science at a young age, absence of role models and mentors from underrepresented backgrounds, and social norms that relegate their career endeavors, particularly among women, to being subordinate to their expected cultural role. The factors influencing the participation of underrepresented minorities in the biomedical workforce are complex and span several continuous or overlapping stages in the professional development of scientists from these groups. Therefore, a multipronged approach is needed to enable the professional development and retention of underrepresented minorities in biomedical research. This approach should address both individual and social factors and should involve funding agencies, academic institutions, mentoring teams, professional societies, and peer collaboration. Implementation of some of the recommendations, such as access to child care, institutional support and health benefits for trainees, teaching and entrepreneurial opportunities, grant-writing webinars, and pre-NIH career development (Pre-K) pilot programs would not only benefit biomedical scientists from underrepresented groups but also improve the situation of nondiverse junior scientists. However, other issues, such as opportunities for early exposure to science of disadvantaged/minority groups, and identifying mentors/life coaches/peer mentors who come from similar cultural backgrounds and vantage points, are unique to this group.

National Heart, Lung, and Blood Institute Workshop Summary: Enhancing Opportunities for Training and Retention of a Diverse Biomedical Workforce

PubMed Central

Duncan, Gregg A.; Lockett, Angelia; Villegas, Leah R.; Almodovar, Sharilyn; Gomez, Jose L.; Flores, Sonia C.; Tigno, Xenia T.

2016-01-01

Rationale: Committed to its mission of conducting and supporting research that addresses the health needs of all sectors of the nation's population, the Division of Lung Diseases, National Heart, Lung, and Blood Institute of the National Institutes of Health (NHLBI/NIH) seeks to identify issues that impact the training and retention of underrepresented individuals in the biomedical research workforce. Objectives: Early-stage investigators who received grant support through the NIH Research Supplements to Promote Diversity in Health Related Research Program were invited to a workshop held in Bethesda, Maryland in June, 2015, in order to (1) assess the effectiveness of the current NHLBI diversity program, (2) improve its strategies towards achieving its goal, and (3) provide guidance to assist the transition of diversity supplement recipients to independent NIH grant support. Methods: Workshop participants participated in five independent focus groups to discuss specific topics affecting underrepresented individuals in the biomedical sciences: (1) Socioeconomic barriers to success for diverse research scientists; (2) role of the academic research community in promoting diversity; (3) life beyond a research project grant: non–primary investigator career paths in research; (4) facilitating career development of diverse independent research scientists through NHLBI diversity programs; and (5) effectiveness of current NHLBI programs for promoting diversity of the biomedical workforce. Measurements and Main Results: Several key issues experienced by young, underrepresented biomedical scientists were identified, and solutions were proposed to improve on training and career development for diverse students, from the high school to postdoctoral trainee level, and address limitations of currently available diversity programs. Although some of the challenges mentioned, such as cost of living, limited parental leave, and insecure extramural funding, are also likely faced by nonminority scientists, these issues are magnified among diversity scientists and are complicated by unique circumstances in this group, such as limited exposure to science at a young age, absence of role models and mentors from underrepresented backgrounds, and social norms that relegate their career endeavors, particularly among women, to being subordinate to their expected cultural role. Conclusions: The factors influencing the participation of underrepresented minorities in the biomedical workforce are complex and span several continuous or overlapping stages in the professional development of scientists from these groups. Therefore, a multipronged approach is needed to enable the professional development and retention of underrepresented minorities in biomedical research. This approach should address both individual and social factors and should involve funding agencies, academic institutions, mentoring teams, professional societies, and peer collaboration. Implementation of some of the recommendations, such as access to child care, institutional support and health benefits for trainees, teaching and entrepreneurial opportunities, grant-writing webinars, and pre-NIH career development (Pre-K) pilot programs would not only benefit biomedical scientists from underrepresented groups but also improve the situation of nondiverse junior scientists. However, other issues, such as opportunities for early exposure to science of disadvantaged/minority groups, and identifying mentors/life coaches/peer mentors who come from similar cultural backgrounds and vantage points, are unique to this group. PMID:27058184

An ethics safe harbor for international genomics research?

PubMed Central

2013-01-01

Background Genomics research is becoming increasingly globally connected and collaborative, contesting traditional ethical and legal boundaries between global and local research practice. As well, global data-driven genomics research holds great promise for health discoveries. Yet, paradoxically, current research ethics review systems around the world challenge potential improvements in human health from such research and thus undermine respect for research participants. Case reports illustrate that the current system is costly, fragmented, inefficient, inadequate, and inconsistent. There is an urgent need to improve the governance system of ethics review to enable secure and seamless genomic and clinical data sharing across jurisdictions. Discussion Building on the international privacy 'safe harbor’ model that was developed following the adoption of the European Privacy Directive, we propose an international infrastructure. The goal is to create a streamlined and harmonized ethics governance system for international, data-driven genomics research projects. The proposed 'Safe Harbor Framework for International Ethics Equivalency’ would consist in part of an agency supporting an International Federation for Ethics Review (IFER), formed by a voluntary agreement among countries, granting agencies, philanthropies, institutions, and healthcare, patient advocacy, and research organizations. IFER would be both a central ethics review body and also a forum for review and follow-up of policies concerning ethics norms for international genomics research projects. It would be built on five principle elements: (1) registration; (2) compliance review; (3) recognition; (4) monitoring and enforcement; and (5) public participation. Summary A Safe Harbor Framework for International Ethics Equivalency would create many benefits for researchers, countries, and the general public, and may eventually have application beyond genomics to other areas of biomedical research that increasingly engage in secondary use of data and present only negligible risks. Among the benefits, research participants and patients would have uniform adequate protection, while researchers would be ensured expert ethics review with a reduction in cost, time, administrative hassle, and redundant regulatory hurdles. Most importantly, society would enjoy the maximization of the potential benefits of genomics research. PMID:24267880

Background radiation measurements at high power research reactors

DOE PAGES

Ashenfelter, J.; Yeh, M.; Balantekin, B.; ...

2015-10-23

Research reactors host a wide range of activities that make use of the intense neutron fluxes generated at these facilities. Recent interest in performing measurements with relatively low event rates, e.g. reactor antineutrino detection, at these facilities necessitates a detailed understanding of background radiation fields. Both reactor-correlated and naturally occurring background sources are potentially important, even at levels well below those of importance for typical activities. Here we describe a comprehensive series of background assessments at three high-power research reactors, including γ-ray, neutron, and muon measurements. For each facility we describe the characteristics and identify the sources of the backgroundmore » fields encountered. Furthermore, the general understanding gained of background production mechanisms and their relationship to facility features will prove valuable for the planning of any sensitive measurement conducted therein.« less

Waterpipe Smoking and Regulation in the United States: A Comprehensive Review of the Literature

PubMed Central

Haddad, Linda; El-Shahawy, Omar; Ghadban, Roula; Barnett, Tracey E.; Johnson, Emily

2015-01-01

Background: Researchers in tobacco control are concerned about the increasing prevalence of waterpipe smoking in the United States, which may pose similar risks as cigarette smoking. This review explores the prevalence of waterpipe smoking in the United States as well as the shortcomings of current U.S. policy for waterpipe control and regulation. Methods: Researchers conducted a literature review for waterpipe articles dated between 2004 and 2015 using five online databases: MEDLINE, CINHAHL, ScienceDirect, PMC, and Cochrane Library. Results: To date, few studies have explored the marketing and regulation of waterpipe smoking in the U.S., which has increased in the last ten years, especially among women, adolescents, and young adults. Data indicate that the majority of waterpipe smokers are unaware of the potential risks of use. In addition, current tobacco control policies do not address waterpipe smoking, enabling tobacco companies to readily market and sell waterpipe products to young adults, who are at risk for becoming lifelong smokers. Conclusion: Policy makers in the area of public health need to update existing tobacco regulations to include waterpipe smoking. Similarly, public health researchers should develop public health campaigns and interventions to address the increasing rates of waterpipe smoking in the United States. PMID:26110330

Socioeconomic influences on brain function: implications for health.

PubMed

Muscatell, Keely A

2018-06-27

Socioeconomic-based disparities in physical health outcomes are well established, with individuals from lower socioeconomic status (SES) backgrounds being more likely to experience chronic disease morbidity and early mortality compared to those from higher SES strata. While numerous studies in recent decades have focused on understanding the contextual, psychosocial, and biological mechanisms linking SES and health, the neural pathways that contribute to this relationship are currently underinvestigated. The present paper reviews and synthesizes the small number of published studies that have explored links between SES and health-relevant neural functioning. Specifically, current knowledge of the relationship between socioeconomic factors and neural systems that may be affected by low SES contexts, including those related to processing threat and stress, responding to reward, and engaging in emotion regulation, is reviewed. Gaps in our knowledge that could be filled by health neuroscience research are emphasized, in an effort to catalyze future studies in this area. Understanding the neural mechanisms linking SES and health is crucial for building comprehensive models of the pathways by which social inequalities become health inequalities and may help identify novel targets for intervention to prevent health disparities. Health neuroscience research has a critical role to play in this important area of research. © 2018 New York Academy of Sciences.

Masticatory muscle sleep background electromyographic activity is elevated in myofascial temporomandibular disorder patients.

PubMed

Raphael, K G; Janal, M N; Sirois, D A; Dubrovsky, B; Wigren, P E; Klausner, J J; Krieger, A C; Lavigne, G J

2013-12-01

Despite theoretical speculation and strong clinical belief, recent research using laboratory polysomnographic (PSG) recording has provided new evidence that frequency of sleep bruxism (SB) masseter muscle events, including grinding or clenching of the teeth during sleep, is not increased for women with chronic myofascial temporomandibular disorder (TMD). The current case-control study compares a large sample of women suffering from chronic myofascial TMD (n = 124) with a demographically matched control group without TMD (n = 46) on sleep background electromyography (EMG) during a laboratory PSG study. Background EMG activity was measured as EMG root mean square (RMS) from the right masseter muscle after lights out. Sleep background EMG activity was defined as EMG RMS remaining after activity attributable to SB, other orofacial activity, other oromotor activity and movement artefacts were removed. Results indicated that median background EMG during these non-SB event periods was significantly higher (P < 0·01) for women with myofascial TMD (median = 3·31 μV and mean = 4·98 μV) than for control women (median = 2·83 μV and mean = 3·88 μV) with median activity in 72% of cases exceeding control activity. Moreover, for TMD cases, background EMG was positively associated and SB event-related EMG was negatively associated with pain intensity ratings (0-10 numerical scale) on post-sleep waking. These data provide the foundation for a new focus on small, but persistent, elevations in sleep EMG activity over the course of the night as a mechanism of pain induction or maintenance. © 2013 John Wiley & Sons Ltd.

Delivering patient decision aids on the Internet: definitions, theories, current evidence, and emerging research areas

PubMed Central

2013-01-01

Background In 2005, the International Patient Decision Aids Standards Collaboration identified twelve quality dimensions to guide assessment of patient decision aids. One dimension—the delivery of patient decision aids on the Internet—is relevant when the Internet is used to provide some or all components of a patient decision aid. Building on the original background chapter, this paper provides an updated definition for this dimension, outlines a theoretical rationale, describes current evidence, and discusses emerging research areas. Methods An international, multidisciplinary panel of authors examined the relevant theoretical literature and empirical evidence through 2012. Results The updated definition distinguishes Internet-delivery of patient decision aids from online health information and clinical practice guidelines. Theories in cognitive psychology, decision psychology, communication, and education support the value of Internet features for providing interactive information and deliberative support. Dissemination and implementation theories support Internet-delivery for providing the right information (rapidly updated), to the right person (tailored), at the right time (the appropriate point in the decision making process). Additional efforts are needed to integrate the theoretical rationale and empirical evidence from health technology perspectives, such as consumer health informatics, user experience design, and human-computer interaction. Despite Internet usage ranging from 74% to 85% in developed countries and 80% of users searching for health information, it is unknown how many individuals specifically seek patient decision aids on the Internet. Among the 86 randomized controlled trials in the 2011 Cochrane Collaboration’s review of patient decision aids, only four studies focused on Internet-delivery. Given the limited number of published studies, this paper particularly focused on identifying gaps in the empirical evidence base and identifying emerging areas of research. Conclusions As of 2012, the updated theoretical rationale and emerging evidence suggest potential benefits to delivering patient decision aids on the Internet. However, additional research is needed to identify best practices and quality metrics for Internet-based development, evaluation, and dissemination, particularly in the areas of interactivity, multimedia components, socially-generated information, and implementation strategies. PMID:24625064

Patient Portals and Patient Engagement: A State of the Science Review

PubMed Central

DeVito Dabbs, Annette; Curran, Christine R

2015-01-01

Background Patient portals (ie, electronic personal health records tethered to institutional electronic health records) are recognized as a promising mechanism to support greater patient engagement, yet questions remain about how health care leaders, policy makers, and designers can encourage adoption of patient portals and what factors might contribute to sustained utilization. Objective The purposes of this state of the science review are to (1) present the definition, background, and how current literature addresses the encouragement and support of patient engagement through the patient portal, and (2) provide a summary of future directions for patient portal research and development to meaningfully impact patient engagement. Methods We reviewed literature from 2006 through 2014 in PubMed, Ovid Medline, and PsycInfo using the search terms “patient portal” OR “personal health record” OR “electronic personal health record”. Final inclusion criterion dictated that studies report on the patient experience and/or ways that patients may be supported to make competent health care decisions and act on those decisions using patient portal functionality. Results We found 120 studies that met the inclusion criteria. Based on the research questions, explicit and implicit aims of the studies, and related measures addressed, the studies were grouped into five major topics (patient adoption, provider endorsement, health literacy, usability, and utility). We discuss the findings and conclusions of studies that address the five topical areas. Conclusions Current research has demonstrated that patients’ interest and ability to use patient portals is strongly influenced by personal factors such age, ethnicity, education level, health literacy, health status, and role as a caregiver. Health care delivery factors, mainly provider endorsement and patient portal usability also contribute to patient’s ability to engage through and with the patient portal. Future directions of research should focus on identifying specific populations and contextual considerations that would benefit most from a greater degree of patient engagement through a patient portal. Ultimately, adoption by patients and endorsement by providers will come when existing patient portal features align with patients’ and providers’ information needs and functionality. PMID:26104044

Breaking Down the Door: A Nonprofit Model Creating Pathways for Non-Traditional STEM Student Engagement

NASA Astrophysics Data System (ADS)

Pelaez, C.; Pelaez, J.

2015-12-01

Blueprint Earth was created as a nonprofit scientific research organization dedicated to conducting micro-scale interdisciplinary environmental investigations to generate macroscopic, system-level environmental understanding. The field data collection and analysis process was conceived to be dependent on student participation and collaboration with more senior scientists, effecting knowledge transfer and emphasizing the critical nature of interdisciplinary research in investigating complex, macroscopic questions. Recruiting for student volunteer researchers is conducted in academic institutions, and to date has focused primarily on the Los Angeles area. Self-selecting student participation has run contrary to traditional STEM demographics. The vast majority of research participants in Blueprint Earth's work are female and/or from a minority (non-white) background, and most are first-generation college students or from low-income, Pell grant-eligible households. Traditional field research programs for students often come at a high cost, creating barriers to access for field-based STEM opportunities. The nonprofit model employed by Blueprint Earth provides zero-cost access to opportunity for students that the STEM world is currently targeting for future professional development.