Exoplanet Atmospheres: From Light-Curve Analyses to Radiative-Transfer Modeling

NASA Astrophysics Data System (ADS)

Cubillos, Patricio; Harrington, Joseph; Blecic, Jasmina; Rojo, Patricio; Stemm, Madison; Lust, Nathaniel B.; Foster, Andrew S.; Loredo, Thomas J.

2015-01-01

Multi-wavelength transit and secondary-eclipse light-curve observations are some of the most powerful techniques to probe the thermo-chemical properties of exoplanets. Although the small planet-to-star constrast ratios demand a meticulous data analysis, and the limited available spectral bands can further restrain constraints, a Bayesian approach can robustly reveal what constraints can we set, given the data.We review the main aspects considered during the analysis of Spitzer time-series data by our group with an aplication to WASP-8b and TrES-1. We discuss the applicability and limitations of the most commonly used correlated-noise estimators. We describe our open-source Bayesian Atmospheric Radiative Transfer (BART) code. BART calculates the planetary emission or transmission spectrum by solving a 1D line-by-line radiative-transfer equation. The generated spectra are integrated over determined bandpasses for comparison to the data. Coupled to our Multi-core Markov-chain Monte Carlo (MC3) statistical package, BART constrains the temperature profile and chemical abundances in the planet's atmosphere. We apply the BART retrieval code to the HD 209458b data set to estimate the planet's temperature profile and molecular abundances.This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G. JB holds a NASA Earth and Space Science Fellowship.

Bayesian Atmospheric Radiative Transfer (BART)Thermochemical Equilibrium Abundance (TEA) Code and Application to WASP-43b

NASA Astrophysics Data System (ADS)

Blecic, Jasmina; Harrington, Joseph; Bowman, Matthew O.; Cubillos, Patricio E.; Stemm, Madison; Foster, Andrew

2014-11-01

We present a new, open-source, Thermochemical Equilibrium Abundances (TEA) code that calculates the abundances of gaseous molecular species. TEA uses the Gibbs-free-energy minimization method with an iterative Lagrangian optimization scheme. It initializes the radiative-transfer calculation in our Bayesian Atmospheric Radiative Transfer (BART) code. Given elemental abundances, TEA calculates molecular abundances for a particular temperature and pressure or a list of temperature-pressure pairs. The code is tested against the original method developed by White at al. (1958), the analytic method developed by Burrows and Sharp (1999), and the Newton-Raphson method implemented in the open-source Chemical Equilibrium with Applications (CEA) code. TEA is written in Python and is available to the community via the open-source development site GitHub.com. We also present BART applied to eclipse depths of WASP-43b exoplanet, constraining atmospheric thermal and chemical parameters. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G. JB holds a NASA Earth and Space Science Fellowship.

Guidelines for designing short-term bird monitoring projects

Treesearch

Jonathan Bart

2005-01-01

The Coordinated Bird Monitoring Program (Bart and Ralph, this volume) program is helping biologists around the country design short-term monitoring projects for birds. We have found that addressing a series of questions (table 1), in a systematic way, helps insure that projects are well planned. The process is being used by several States and...

Clinical and molecular genetic features of Hb H and AE Bart's diseases in central Thai children.

PubMed

Traivaree, Chanchai; Boonyawat, Boonchai; Monsereenusorn, Chalinee; Rujkijyanont, Piya; Photia, Apichat

2018-01-01

α-Thalassemia, one of the major thalassemia types in Thailand, is caused by either deletion or non-deletional mutation of one or both α-globin genes. Inactivation of three α-globin genes causes hemoglobin H (Hb H) disease, and the combination of Hb H disease with heterozygous hemoglobin E (Hb E) results in AE Bart's disease. This study aimed to characterize the clinical and hematological manifestations of 76 pediatric patients with Hb H and AE Bart's diseases treated at Phramongkutklao Hospital, a tertiary care center for thalassemia patients in central Thailand. Seventy-six unrelated pediatric patients, 58 patients with Hb H disease and 18 patients with AE Bart's disease, were enrolled in this study. Their clinical presentations, transfusion requirement, laboratory findings, and mutation analysis were retrospectively reviewed and analyzed. A total of 76 pediatric patients with Hb H and AE Bart's diseases who mainly lived in central Thailand were included in this study. The clinical severities of patients with non-deletional mutations were more severe than those with deletional mutations. Eighty-six percent of patients with non-deletional AE Bart's disease required more blood transfusion compared to 12.5% of patients with deletional AE Bart's disease. Non-deletional AE Bart's disease also had a history of urgent blood transfusion with the average of 6±0.9 times compared to 1±0.3 times in patients with deletional Hb H disease. The difference was statistically significant. This study revealed the differences in clinical spectrum between patients with Hb H disease and those with AE Bart's disease in central Thailand. The differentiation of α-thalassemia is essential for appropriate management of patients. The molecular diagnosis is useful for diagnostic confirmation and genotype-phenotype correlation.

Neonatal screening for sickle cell disease, glucose-6-phosphate dehydrogenase deficiency and a-thalassemia in Qatif and Al Hasa.

PubMed

Nasserullah, Z; Al Jame, A; Abu Srair, H; Al Qatari, G; Al Naim, S; Al Aqib, A; Mokhtar, M

1998-01-01

Screening programs to determine the frequency of sickle cell, glucose-6-phosphate dehydrogenase deficiency and alpha-thalassemia gene are available in Saudi Arabia, although not used frequently. Greater use of these programs will decrease the morbidity and mortality of Saudi children affected by these disorders. Neonatal hemoglobin electrophoresis and glucose-6-dehydrogenase fluorescent spot tests were performed on newborn babies delivered between December 1992 and December 1993 at the Qatif Central Hospital and at the King Fahad Hospital in Al Hasa. Cord blood samples were collected from babies born in these two hospitals. Babies born in other hospitals had blood collected in their first visit to Qatif primary care centers at the time of vaccination. All specimens were sent to Dammam Central Laboratory. The diagnosis of sickle cell and alpha-thalassemia was based on cellulose acetate electrophoresis and confirmed by agar gel electrophoresis, and glucose-6-phosphate dehydrogenase was confirmed by fluorescent spot test. A total of 12,220 infants, including 11,313 Saudis (92.6%), were screened over a 12-month period. The common phenotypes detected in these infants included AF, AF Bartâs, SFA, SFA Bartâs, FS and FS Bartâs. In the Saudi infants, homozygous sickle cell disease was detected in 2.35% and 1.08% in Qatif and Al Hasa, respectively. The frequencies of sickle cell gene were 0.1545% and 0.1109% in Qatif and Al Hasa. alphathalassemia gene based on an elevated level of Hb Bartâs were 28% and 16.3% in Qatif and Al Hasa. The screening for G6PD deficiency revealed a high prevalence of 30.6% and 14.7% in Qatif and Al Hasa. In the non-Saudi infants, the frequencies were low. The outcome of this study indicates that the Saudi populations in Qatif and Al Hasa are at risk for hemoglobinopathies and G6PD. Neonatal screening programs are essential and cost effective and should be maintained as a routine practice.

76 FR 80754 - Approval and Promulgation of Implementation Plans; State of Kansas: Regional Haze

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... available in the docket for this rulemaking. The supplemental dispersion modeling provided by the State was... determined by using SNCR costs obtained from Jeffrey Unit 1, and scaling the dollar amount using heat input... impact of Kansas BART sources on all Class I areas impacted. NPCA says that the modeling results...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurlbut, D. J.; Haase, S.; Brinkman, G.

Pursuant to the Clean Air Act, the U.S. Environmental Protection Agency (EPA) announced in 2009 its intent to issue rules for controlling emissions from Navajo Generating Station that could affect visibility at the Grand Canyon and at several other national parks and wilderness areas. The final rule will conform to what EPA determines is the best available retrofit technology (BART) for the control of haze-causing air pollutants, especially nitrogen oxides. While EPA is ultimately responsible for setting Navajo Generating Station's BART standards in its final rule, it will be the U.S. Department of the Interior's responsibility to manage compliance andmore » the related impacts. This study aims to assist both Interior and EPA by providing an objective assessment of issues relating to the power sector.« less

A Tribute to Bart Longenecker: An IS Education Maverick and Visionary

ERIC Educational Resources Information Center

Landry, Jeffrey P.; Pardue, J. Harold; Daigle, Roy J.

2018-01-01

Bart Longenecker was one of the most influential Information Systems (IS) educators ever. Renowned for his decades of work on IS model curricula, Bart died in 2016 after a 44-year career. This paper traces the life's work of this EDSIG Fellow and Professor Emeritus to capture his IS education legacy.

Aufbau des humanoiden Roboters BART III

NASA Astrophysics Data System (ADS)

Resetov, Dimitri; Pietsch, Björn; Gerth, Wilfried

Der vorliegende Beitrag präsentiert den humanoiden Roboter BART III, der am Institut für Regelungstechnik als eine robuste und erweiterbare Plattform für weiterführende Grundlagenforschung zur zweibeinigen Fortbewegung entwickelt wurde. Im Gegensatz zu den bisher am IRT genutzten Robotern BARt-UH und LISA besitzt der neue Roboter einen beweglichen Oberkörper mit einem Bauchgelenk und Armen. BART III besitzt insgesamt 19 aktive Freiheitsgrade, 12 davon im Unterkörper. Ein weiteres Merkmal des Roboters ist die im gesamten Körper verteilte Ansteuerelektronik, die neben der lokalen Motorregelung diverse sicherheitsrelevante Funktionen übernimmt.

78 FR 60700 - Source Specific Federal Implementation Plan for Implementing Best Available Retrofit Technology...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-02

... operator of FCPP must notify EPA of its selected BART compliance strategy. On June 19, 2013, APS requested... related to the potential deregulation of the retail electricity market in Arizona that complicate its... one of two strategies for BART compliance: (1) Compliance with a facility-wide BART emission limit for...

Bayesian Atmospheric Radiative Transfer (BART): Model, Statistics Driver, and Application to HD 209458b

NASA Astrophysics Data System (ADS)

Cubillos, Patricio; Harrington, Joseph; Blecic, Jasmina; Stemm, Madison M.; Lust, Nate B.; Foster, Andrew S.; Rojo, Patricio M.; Loredo, Thomas J.

2014-11-01

Multi-wavelength secondary-eclipse and transit depths probe the thermo-chemical properties of exoplanets. In recent years, several research groups have developed retrieval codes to analyze the existing data and study the prospects of future facilities. However, the scientific community has limited access to these packages. Here we premiere the open-source Bayesian Atmospheric Radiative Transfer (BART) code. We discuss the key aspects of the radiative-transfer algorithm and the statistical package. The radiation code includes line databases for all HITRAN molecules, high-temperature H2O, TiO, and VO, and includes a preprocessor for adding additional line databases without recompiling the radiation code. Collision-induced absorption lines are available for H2-H2 and H2-He. The parameterized thermal and molecular abundance profiles can be modified arbitrarily without recompilation. The generated spectra are integrated over arbitrary bandpasses for comparison to data. BART's statistical package, Multi-core Markov-chain Monte Carlo (MC3), is a general-purpose MCMC module. MC3 implements the Differental-evolution Markov-chain Monte Carlo algorithm (ter Braak 2006, 2009). MC3 converges 20-400 times faster than the usual Metropolis-Hastings MCMC algorithm, and in addition uses the Message Passing Interface (MPI) to parallelize the MCMC chains. We apply the BART retrieval code to the HD 209458b data set to estimate the planet's temperature profile and molecular abundances. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G. JB holds a NASA Earth and Space Science Fellowship.

77 FR 31691 - Approval and Promulgation of Implementation Plans; State of Hawaii; Regional Haze Federal...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-29

... Subject to BART 3. BART Determination for Kanoelehua Hill a. BART for NO X and Particulate Matter (PM) b.... The initials PM mean or refer to particulate matter. xxiv. The initials PM2.5 mean or refer to particulate matter with an aerodynamic diameter of less than 2.5 micrometers (fine particulate matter). xxv...

A novel device for studying weight supported, quadrupedal overground locomotion in spinal cord injured rats.

PubMed

Hamlin, Marvin; Traughber, Terence; Reinkensmeyer, David J; de Leon, Ray D

2015-05-15

Providing weight support facilitates locomotion in spinal cord injured animals. To control weight support, robotic systems have been developed for treadmill stepping and more recently for overground walking. We developed a novel device, the body weight supported ambulatory rodent trainer (i.e. BART). It has a small pneumatic cylinder that moves along a linear track above the rat. When air is supplied to the cylinder, the rats are lifted as they perform overground walking. We tested the BART device in rats that received a moderate spinal cord contusion injury and in normal rats. Locomotor training with the BART device was not performed. All of the rats learned to walk in the BART device. In the contused rats, significantly greater paw dragging and dorsal stepping occurred in the hindlimbs compared to normal. Providing weight support significantly raised hip position and significantly reduced locomotor deficits. Hindlimb stepping was tightly coupled to forelimb stepping but only when the contused rats stepped without weight support. Three weeks after the contused rats received a complete spinal cord transection, significantly fewer hindlimb steps were performed. Relative to rodent robotic systems, the BART device is a simpler system for studying overground locomotion. The BART device lacks sophisticated control and sensing capability, but it can be assembled relatively easily and cheaply. These findings suggest that the BART device is a useful tool for assessing quadrupedal, overground locomotion which is a more natural form of locomotion relative to treadmill locomotion. Published by Elsevier B.V.

Development of an Automated Emergency Response System (AERS) for Rail Transit Systems

DOT National Transportation Integrated Search

1984-10-01

As a result of a fire in 1979 at the Bay Area Rapid Transit District (BART), a microprocessor-based information retrieval system was developed to aid in the emergency decision-making process. This system was proposed, designed and programmed by a sup...

Rail transit fare collection: Policy and technology assessment

NASA Technical Reports Server (NTRS)

Deshpande, G. K.; Cucchissi, J.; Heft, R. C.

1982-01-01

The impact of fare policies and fare structure on the selection of equipment was investigated, fare collection systems are described, hardware and technology related problems are documented, and the requirements of a fare collection simulation model are outlined. Major findings include: (1) a wide variation in the fare collection systems and equipment, caused primarily by historical precedence; (2) the reliability of AFC equipment used at BART and WMATA discouraged other properties from considering use of similar equipment; (3) existing equipment may not meet the fare collection needs of properties in the near future; (4) the cost of fare collection operation and maintenance is high; and (5) the relatively small market in fare collection equipment discourages new product development by suppliers. Recommendations for fare collection R&D programs include development of new hardware to meet rail transit needs, study of impacts of alternate fare policies increased communication among policymakers, and consensus on fare policy issues.

40 CFR 51.308 - Regional haze program requirements.

Code of Federal Regulations, 2012 CFR

2012-07-01

... for fossil-fuel fired power plants having a total generating capacity greater than 750 megawatts must...) and (e) of this section. The progress reports must be in the form of implementation plan revisions... Federal Implementation Plan need not require BART-eligible fossil fuel-fired steam electric plants in the...

A novel device for studying weight supported, quadrupedal overground locomotion in spinal cord injured rats

PubMed Central

Hamlin, Marvin; Traughber, Terrance; Reinkensmeyer, David J.; de Leon, Ray D.

2015-01-01

Background Providing weight support facilitates locomotion in spinal cord injured animals. To control weight support, robotic systems have been developed for treadmill stepping and more recently for overground walking. New Method We developed a novel device, the body weight supported ambulatory rodent trainer (i.e. BART). It has a small pneumatic cylinder that moves along a linear track above the rat. When air is supplied to the cylinder, the rats are lifted as they perform overground walking. We tested the BART device in rats that received a moderate spinal cord contusion injury and in normal rats. Locomotor training with the BART device was not performed. Results All of the rats learned to walk in the BART device. In the contused rats, significantly greater paw dragging and dorsal stepping occurred in the hindlimbs compared to normal. Providing weight support significantly raised hip position and significantly reduced locomotor deficits. Hindlimb stepping was tightly coupled to forelimb stepping but only when the contused rats stepped without weight support. Three weeks after the contused rats received a complete spinal cord transection, significantly fewer hindlimb steps were performed. Comparison with Existing Methods Relative to rodent robotic systems, the BART device is a simpler system for studying overground locomotion. The BART device lacks sophisticated control and sensing capability, but it can be assembled relatively easily and cheaply. Conclusions These findings suggest that the BART device is a useful tool for assessing quadrupedal, overground locomotion which is a more natural form of locomotion relative to treadmill locomotion. PMID:25794460

A Novel Persistence Associated EBV miRNA Expression Profile Is Disrupted in Neoplasia

PubMed Central

Qiu, Jin; Cosmopoulos, Katherine; Pegtel, Michiel; Hopmans, Erik; Murray, Paul; Middeldorp, Jaap; Shapiro, Michael; Thorley-Lawson, David A.

2011-01-01

We have performed the first extensive profiling of Epstein-Barr virus (EBV) miRNAs on in vivo derived normal and neoplastic infected tissues. We describe a unique pattern of viral miRNA expression by normal infected cells in vivo expressing restricted viral latency programs (germinal center: Latency II and memory B: Latency I/0). This includes the complete absence of 15 of the 34 miRNAs profiled. These consist of 12 BART miRNAs (including approximately half of Cluster 2) and 3 of the 4 BHRF1 miRNAs. All but 2 of these absent miRNAs become expressed during EBV driven growth (Latency III). Furthermore, EBV driven growth is accompanied by a 5–10 fold down regulation in the level of the BART miRNAs expressed in germinal center and memory B cells. Therefore, Latency III also expresses a unique pattern of viral miRNAs. We refer to the miRNAs that are specifically expressed in EBV driven growth as the Latency III associated miRNAs. In EBV associated tumors that employ Latency I or II (Burkitt's lymphoma, Hodgkin's disease, nasopharyngeal carcinoma and gastric carcinoma), the Latency III associated BART but not BHRF1 miRNAs are up regulated. Thus BART miRNA expression is deregulated in the EBV associated tumors. This is the first demonstration that Latency III specific genes (the Latency III associated BARTs) can be expressed in these tumors. The EBV associated tumors demonstrate very similar patterns of miRNA expression yet were readily distinguished when the expression data were analyzed either by heat-map/clustering or principal component analysis. Systematic analysis revealed that the information distinguishing the tumor types was redundant and distributed across all the miRNAs. This resembles “secret sharing” algorithms where information can be distributed among a large number of recipients in such a way that any combination of a small number of recipients is able to understand the message. Biologically, this may be a consequence of functional redundancy between the miRNAs. PMID:21901094

Atmospheric Retrievals from Exoplanet Observations and Simulations with BART

NASA Astrophysics Data System (ADS)

Harrington, Joseph

This project will determine the observing plans needed to retrieve exoplanet atmospheric composition and thermal profiles over a broad range of planets, stars, instruments, and observing modes. Characterizing exoplanets is hard. The dim planets orbit bright stars, giving orders of magnitude more relative noise than for solar-system planets. Advanced statistical techniques are needed to determine what the data can - and more importantly cannot - say. We therefore developed Bayesian Atmospheric Radiative Transfer (BART). BART explores the parameter space of atmospheric chemical abundances and thermal profiles using Differential-Evolution Markov-Chain Monte Carlo. It generates thousands of candidate spectra, integrates over observational bandpasses, and compares to data, generating a statistical model for an atmosphere's composition and thermal structure. At best, it gives abundances and thermal profiles with uncertainties. At worst, it shows what kinds of planets the data allow. It also gives parameter correlations. BART is open-source, designed for community use and extension (http://github.com/exosports/BART). Three arXived PhD theses (papers in publication) provide technical documentation, tests, and application to Spitzer and HST data. There are detailed user and programmer manuals and community support forums. Exoplanet analysis techniques must be tested against synthetic data, where the answer is known, and vetted by statisticians. Unfortunately, this has rarely been done, and never sufficiently. Several recent papers question the entire body of Spitzer exoplanet observations, because different analyses of the same data give different results. The latest method, pixel-level decorrelation, produces results that diverge from an emerging consensus. We do not know the retrieval problem's strengths and weaknesses relative to low SNR, red noise, low resolution, instrument systematics, or incomplete spectral line lists. In observing eclipses and transits, we assume the planet has uniform composition and the same temperature profile everywhere. We do not know this assumption's impact. While Spitzer and HST have few exoplanet observing modes, JWST will have over 20. Given the signal challenges and the complexity of retrieval, modeling the observations and data analysis is the best way to optimize an observing plan. Our project solves all of these problems. Using only open-source codes, with tools available to the community for their immediate application in JWST and HST proposals and analyses, we will produce a faithful simulator of 2D spectral and photometric frames from each JWST exoplanet mode (WFC3 spatial scan mode works already), including jitter and intrapixel effects. We will extract and calibrate data, analyzing them with BART. Given planetary input spectra for terrestrial, super-Earth, Neptune, and Jupiterclass planets, and a variety of stellar spectra, we will determine the best combination of observations to recover each atmosphere, and the limits where low SNR or spectral coverage produce deceptive results. To facilitate these analyses, we will adapt an existing cloud model to BART, add condensate code now being written to its thermochemical model, include scattering, add a 3D atmosphere module (for dayside occultation mapping and the 1D vs. 3D question), and improve performance and documentation, among other improvements. We will host a web site and community discussions online and at conferences about retrieval issues. We will develop validation tests for radiative-transfer and BART-style retrieval codes, and provide examples to validate others' codes. We will engage the retrieval community in data challenges. We will provide web-enabled tools to specify planets easily for modeling. We will make all of these tools, tests, and comparisons available online so everyone can use them to maximize NASA's investment in high-end observing capabilities to characterize exoplanets.

77 FR 21896 - Approval and Promulgation of Air Quality Implementation Plans; State of Nevada; Regional Haze...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-12

... proposed approval, including specific comments on NDEP's modeling and cost analysis of the RGGS BART Determination for NO X . See Modeling for the Reid Gardner Generating Station: Visibility Impacts in Class I... independent modeling analysis to evaluate the incremental visibility improvement attributable to the NO X...

76 FR 36450 - Approval and Promulgation of Air Quality Implementation Plans; State of Nevada; Regional Haze...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

... Technology (BART) E. Long-Term Strategy (LTS) F. Coordination of the Regional Haze SIP and Reasonably... for 2018 2. Establishing the Reasonable Progress Goal 3. Interstate Consultation G. Long-Term Strategy... implementation of the regional haze program will require long-term coordination among states, Tribal governments...

77 FR 11879 - Approval and Promulgation of Air Quality Implementation Plans; State of Mississippi; Regional...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-28

... Goals (RPGs) D. Best Available Retrofit Technology (BART) E. Long-Term Strategy (LTS) F. Coordinating... analysis of Mississippi's regional haze submittal? A. No Affected Class I Areas in Mississippi B. Long-Term... haze program will require long-term regional coordination among states, tribal governments, and various...

Risk-Taking Propensity as a Predictor of Induction onto Naltrexone Treatment for Opioid Dependence

PubMed Central

Aklin, Will M.; Severtson, S. Geoffrey; Umbricht, Annie; Fingerhood, Michael; Bigelow, George E.; Lejuez, C. W.; Silverman, Kenneth

2014-01-01

Objective Heroin addiction is a chronic relapsing disorder that has devastating social, medical, and economic consequences. Naltrexone is an antagonist that blocks opioid effects and could be an effective medication for the treatment of opioid dependence. However, its clinical utility has been limited partly because of poor adherence and acceptability. Given the importance of compliance to naltrexone treatment for opioid dependence, the goal of the current study was to examine predictors involved in successful induction onto naltrexone treatment. Method Parametric and nonparametric statistical tests were performed on data from a sample of 64 individuals entering treatment who met DSM-IV criteria for opioid dependence. The relationship between naltrexone induction (i.e., inducted- vs. not-inducted onto naltrexone) and risk-taking propensity, as indexed by riskiness on the Balloon Analogue Risk Task (BART) was examined. Participants were recruited from local detoxification programs, inpatient drug treatment, and other Baltimore programs that provided services to opioid dependent adults (e.g., Baltimore Needle Exchange Program) during the period from August 2007 to September 2008. Results Positive association between risk-taking propensity and odds of naltrexone induction. Specifically, each five point increase in the total BART score was associated with a 25% decrease in odds of naltrexone induction (OR=0.76, 95% CI: 0.58–0.99, p = .041). This association remained statistically significant even after adjusting for potential confounds, including injection drug use and cocaine positive urine results (p = .05). After adjusting for the covariates, each five point increase in BART score was associated with 28% decrease in the odds of achieving the maintenance dose (AOR=0.73, 95% CI: 0.54–0.99, p = .046). Conclusions Risk taking propensity was predictive of induction onto naltrexone treatment, above and beyond injection drug use and cocaine-positive urine samples. PMID:22967782

Insect Species Damage on Ornamental Plants and Saplings of Bartin Province and Its Vicinity in the Western Black Sea Region of Turkey

PubMed Central

Kaygin, Azize Toper; Sönmezyildiz, Hilmi; Ülgentürk, Selma; Özdemir, Işıl

2008-01-01

The objectives of this study were to identify harmful insect species, understand their biology, assess their damage potential and target plants and define distribution areas. There are a lot of native or cultured ornamental plants in Bartın and its surrounding (Çaycuma, Zonguldak, Karabük, Mengen, Devrek). These plants are herbaceous and woody species. Specimens were collected from various cultured and non-cultured plants. A total of 34 species belonging to 20 families of 5 orders were identified. The order Hemiptera was represented by the highest number of species (19 species), followed by Coleoptera (8), Lepidoptera (4), Orthoptera (2), and Dermaptera (1). Insect samples were collected from plants by net traps, special insect aspirators, and various insect traps. The identified species have been stored in the collection room of the Forest Entomology and Protection Unit, Bartın Forestry Faculty, Zonguldak Karaelmas University (Z.K.U.), Turkey. This is the first detailed study about insect species causing damage on ornamental plants and saplings of Bartın province and its vicinity, although similar studies of different regions exist. This research makes a very important contribution to the insect fauna of Bartın, its environs and Turkey. Twenty four of the identified species were new for Bartın and its vicinity, while the remainder had been previously recorded in different parts of Bartın. PMID:19325767

Second Trimester Maternal Serum Screening for Fetal Down Syndrome: as a Screening Test for Hemoglobin Bart's Disease: A Prospective Population-based Study.

PubMed

Wanapirak, Chanane; Piyamomgkol, Wirawit; Sirichotiyakul, Supatra; Tongprasert, Fuanglada; Srisupundit, Kasemsri; Luewan, Suchaya; Traisrisilp, Kuntharee; Jatavan, Phudit; Tongsong, Theera

2018-06-21

To determine the effectiveness of second-trimester maternal serum screening (MSS) for Down syndrome as a screening test for fetal hemoglobin (Hb) Bart's disease among an unselected population. A secondary analysis of a large prospective database (20,254 pregnancies) was conducted to compare the levels of MSS, alpha-fetoprotein (AFP), free beta-human chorionic gonadotropin (hCG) and unconjugated estriol (uE3) between pregnancies with Hb Bart's disease and unaffected pregnancies. The median AFP levels were much higher among affected fetuses, (1.96 vs. 1.12 multiple of the median (MoM); p<0.001), yielding a sensitivity of 81.6% and specificity of 86.4%. Thus, AFP measurement is effective in predicting fetal Hb Bart's disease among an unselected population when using a cut-off value of 1.5 MoM. The serum free b-hCG levels were slightly, but significantly, higher in the affected pregnancies, while the serum uE3 levels were minimally, but significantly, lower among the affected pregnancies. Second trimester maternal serum AFP levels were significantly elevated in cases of fetal Hb Bart's disease. Pregnancies with unexplained elevated serum AFP levels in areas of high prevalence of Hb Bart's disease should always undergo a detailed ultrasound examination to detect any early signs of fetal anemia before development of hydrops fetalis. This article is protected by copyright. All rights reserved.

Partial sleep deprivation impacts impulsive action but not impulsive decision-making.

PubMed

Demos, K E; Hart, C N; Sweet, L H; Mailloux, K A; Trautvetter, J; Williams, S E; Wing, R R; McCaffery, J M

2016-10-01

Sleep deprivation may lead to increased impulsivity, however, previous literature has focused on examining effects of total sleep deprivation (TSD) rather than the more common condition, partial sleep deprivation (PSD) or 'short sleep'. Moreover, it has been unclear whether PSD impacts impulse-related cognitive processes, and specifically if it differentially affects impulsive action versus impulsive decision-making. We sought to determine if short compared to long sleep (6 vs. 9h/night) impacts impulsive action via behavioral inhibition (Go/No-Go), and/or impulsive decision-making processes of risk taking (Balloon Analogue Risk Task [BART]) and preferences for immediate over delayed rewards (Delay Discounting). In a within-subject design, 34 participants (71% female, mean age=37.0years, SD=10.54) were assigned to four consecutive nights of 6h/night (short sleep) and 9h/night (long sleep) in their own home in random counterbalanced order. Sleep was measured via wrist-worn actigraphs to confirm adherence to the sleep schedules (mean short sleep=5.9h, SD=0.3; mean long sleep=8.6h, SD=0.3, p<0.001). The Go/No-Go, BART, and Delay Discounting tasks were completed following both sleep conditions. Participants had more inhibition errors on the Go/No-Go task after short (mean false alarms=19.79%, SD=14.51) versus long sleep (mean=15.97%, SD=9.51, p=0.039). This effect was strongest in participants reporting longer habitual time in bed (p=0.04). There were no differences in performance following long- versus short-sleep for either delay discounting or the BART (p's>0.4). Overall, these results indicate that four days of PSD diminishes behavioral inhibition abilities, but may not alter impulsive decision-making. These findings contribute to the emerging understanding of how partial sleep deprivation, currently an epidemic, impacts cognitive ability. Future research should continue to explore the connection between PSD and cognitive functions, and ways to minimize the occurrence and negative consequences of short sleep. Copyright © 2016 Elsevier Inc. All rights reserved.

Partial sleep deprivation impacts impulsive action but not impulsive decision-making

PubMed Central

Demos, K.E.; Hart, C.N.; Sweet, LH.; Mailloux, K.A.; Trautvetter, J.; Williams, S.E.; Wing, R.R.; McCaffery, J.M.

2017-01-01

Sleep deprivation may lead to increased impulsivity, however, previous literature has focused on examining effects of total sleep deprivation (TSD) rather than the more common condition, partial sleep deprivation (PSD) or ‘short sleep’. Moreover, it has been unclear whether PSD impacts impulse-related cognitive processes, and specifically if it differentially affects impulsive action versus impulsive decision-making. We sought to determine if short compared to long sleep (6 vs. 9 h/night) impacts impulsive action via behavioral inhibition (Go/No-Go), and/or impulsive decision-making processes of risk taking (Balloon Analogue Risk Task [BART]) and preferences for immediate over delayed rewards (Delay Discounting). In a within-subject design, 34 participants (71% female, mean age = 37.0 years, SD = 10.54) were assigned to four consecutive nights of 6 h/night (short sleep) and 9 h/night (long sleep) in their own home in random counterbalanced order. Sleep was measured via wrist-worn actigraphs to confirm adherence to the sleep schedules (mean short sleep = 5.9 h, SD = 0.3; mean long sleep = 8.6 h, SD = 0.3, p < 0.001). The Go/No-Go, BART, and Delay Discounting tasks were completed following both sleep conditions. Participants had more inhibition errors on the Go/No-Go task after short (mean false alarms = 19.79%, SD = 14.51) versus long sleep (mean = 15.97%, SD = 9.51, p = 0.039). This effect was strongest in participants reporting longer habitual time in bed (p = 0.04). There were no differences in performance following long- versus short-sleep for either delay discounting or the BART (p’s > 0.4). Overall, these results indicate that four days of PSD diminishes behavioral inhibition abilities, but may not alter impulsive decision-making. These findings contribute to the emerging understanding of how partial sleep deprivation, currently an epidemic, impacts cognitive ability. Future research should continue to explore the connection between PSD and cognitive functions, and ways to minimize the occurrence and negative consequences of short sleep. PMID:27267950

77 FR 33642 - Regional Haze: Revisions to Provisions Governing Alternatives to Source-Specific Best Available...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-07

... of the Two-Pronged Test 2. Identification of Affected Class I Areas 3. Control Scenarios Examined 4... two-pronged test to the Transport Rule control scenario and the source-specific BART control scenario... approaches to identify the Class I areas ``affected'' by the Transport Rule as an alternative control program...

78 FR 11805 - Approval and Promulgation of Implementation Plans; Region 4 States; 110(a)(2)(D)(i)(II...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-20

... retrofit technology (BART) and reasonable progress requirements for other sources or pollutants, are..., South Carolina and Tennessee regional haze SIPs, indicating that except for its reliance on CAIR, the... Tennessee, which merely substituted reliance on EPA's more recent CSAPR's NO X and SO 2 trading programs for...

Appearance of Abnormal Cardiothoracic Ratio of Fetuses with Hemoglobin Bart's Disease: Life Table Analysis.

PubMed

Wanapirak, Chanane; Sirichotiyakul, Supatra; Luewan, Suchaya; Srisupundit, Kasemsri; Tongprasert, Fuanglada; Tongsong, Theera

2017-10-01

Objective  To determine the timeline of the first appearance of an increased CT ratio of fetuses with hemoglobin (Hb) Bart's disease. Materials and Methods  A prospective longitudinal study was conducted on pregnancies at risk for fetal Hb Bart's disease. Sonographic markers including cardiothoracic (CT) ratio and middle cerebral artery peak systolic velocity (MCA-PSV) were serially assessed and recorded from the first trimester. The definite diagnosis of fetal Hb Bart's disease based on DNA analysis (CVS), or fetal Hb typing (HPLC; cordocentesis) was performed at the first appearance of an increased CT ratio. Results  Of 275 pregnancies at risk, 64 fetuses were finally proven to be affected and life table analysis was performed. Most affected fetuses showed an increased CT ratio in late first trimester and early second trimester, with median time of the first appearance at 13 weeks and all affected fetuses were detected at 23 weeks or less. The CT ratio yielded a sensitivity of 100 % at a gestational age of 23 weeks with a false-positive rate of 8 %. MCA-PSV appeared later than CT ratio. Only 9.4 % of affected cases developed abnormal MCA-PSV before an increased CT ratio. Conclusion  The timeline of the first appearance of an increased CT ratio of fetuses with Hb Bart's disease was established. This may help us identify Hb Bart's disease among fetuses at risk in earlier gestation and proper schedules for serial ultrasound could be made more effectively. © Georg Thieme Verlag KG Stuttgart · New York.

Noninvasive prenatal exclusion of haemoglobin Bart's using foetal DNA from maternal plasma.

PubMed

Ho, Sherry S Y; Chong, Samuel S C; Koay, Evelyn S C; Ponnusamy, Sukumar; Chiu, Lily; Chan, Yiong Huak; Rauff, Mary; Baig, Sonia; Chan, Jerry; Su, Lin Lin; Biswas, Arijit; Hahn, Sinuhe; Choolani, Mahesh

2010-01-01

Prenatal diagnosis of alpha-thalassaemia requires invasive testing associated with a risk of miscarriage. Cell-free foetal DNA in maternal plasma presents an alternative source of foetal genetic material for noninvasive prenatal diagnosis. We aimed to exclude HbBart's noninvasively by detection of unaffected paternal alleles in maternal plasma using quantitative fluorescence PCR (QF-PCR). Microsatellite markers (16PTEL05, 16PTEL06) within the breakpoint regions of -(SEA), -(FIL) and -(THAI) deletions were analysed using QF-PCR of maternal plasma from 30 families. In this blinded study, genotypes were confirmed using conventional PCR. Maternal plasma from two known cases of HbBart's were also analysed. HbBart's was excluded in 10 out of 30 (33.3%, 95% CI, 17.3-52.8%) mothers by identifying the presence of nondeleted paternally inherited fetal alleles; either only 16PTEL05 (n = 1) or only 16PTEL06 (n = 4), or both (n = 5), and confirmed through direct analysis of fetal DNA. Paternally inherited foetal alleles of 16PTEL05 and 16PTEL06 were not detected in maternal plasma of the two known HbBarts cases. False negatives were excluded with the detection of paternally inherited fetal control marker, D21S1270 in maternal plasma. We show proof-of-principle that such a test can accurately exclude HbBart's in the foetus by identifying the nondeleted paternally inherited fetal alleles in maternal plasma in one out of three pregnancies, avoiding invasive testing in these pregnancies. Copyright (c) 2009 John Wiley & Sons, Ltd.

Mass Transit: Actions Needed for the BART Airport Extension

DOT National Transportation Integrated Search

1996-05-31

The Bay Area Rapid Transit District (BART) intends to spend over $1.1 billion, including $750 million in federal funds, to extend mass transit service to the San Francisco International Airport. The project is controversial, encountering both widespr...

BART to Silicon Valley, how now?

DOT National Transportation Integrated Search

2001-09-01

This publication is a transcript and summary of a forum held on April 6, 2001, in which transportation leaders and policy makers convened to discuss how best to proceed with extending the Bay Area Rapid Transit (BART) system to San Jose, California. ...

Review of BART "C" Car Fire Safety Characteristics

DOT National Transportation Integrated Search

1987-09-01

The report presents the results of a review of the fire safety characteristics of the prototype BART "C" Car. Initiated in response to a request from the Urban Mass Transportation Administration (UMTA) Region IX Administrator, the review has been str...

Novel Bioluminescent Quantitative Detection of Nucleic Acid Amplification in Real-Time

PubMed Central

Gandelman, Olga A.; Church, Vicki L.; Moore, Cathy A.; Kiddle, Guy; Carne, Christopher A.; Parmar, Surendra; Jalal, Hamid; Tisi, Laurence C.; Murray, James A. H.

2010-01-01

Background The real-time monitoring of polynucleotide amplification is at the core of most molecular assays. This conventionally relies on fluorescent detection of the amplicon produced, requiring complex and costly hardware, often restricting it to specialised laboratories. Principal Findings Here we report the first real-time, closed-tube luminescent reporter system for nucleic acid amplification technologies (NAATs) enabling the progress of amplification to be continuously monitored using simple light measuring equipment. The Bioluminescent Assay in Real-Time (BART) continuously reports through bioluminescent output the exponential increase of inorganic pyrophosphate (PPi) produced during the isothermal amplification of a specific nucleic acid target. BART relies on the coupled conversion of inorganic pyrophosphate (PPi) produced stoichiometrically during nucleic acid synthesis to ATP by the enzyme ATP sulfurylase, and can therefore be coupled to a wide range of isothermal NAATs. During nucleic acid amplification, enzymatic conversion of PPi released during DNA synthesis into ATP is continuously monitored through the bioluminescence generated by thermostable firefly luciferase. The assay shows a unique kinetic signature for nucleic acid amplifications with a readily identifiable light output peak, whose timing is proportional to the concentration of original target nucleic acid. This allows qualitative and quantitative analysis of specific targets, and readily differentiates between negative and positive samples. Since quantitation in BART is based on determination of time-to-peak rather than absolute intensity of light emission, complex or highly sensitive light detectors are not required. Conclusions The combined chemistries of the BART reporter and amplification require only a constant temperature maintained by a heating block and are shown to be robust in the analysis of clinical samples. Since monitoring the BART reaction requires only a simple light detector, the iNAAT-BART combination is ideal for molecular diagnostic assays in both laboratory and low resource settings. PMID:21152399

Reduced Risk-Taking After Prior Losses in Pathological Gamblers Under Treatment and Healthy Control Group but not in Problem Gamblers.

PubMed

Bonini, Nicolao; Grecucci, Alessandro; Nicolè, Manuel; Savadori, Lucia

2018-06-01

A group of pathological gamblers and a group of problem gamblers (i.e., gamblers at risk of becoming pathological) were compared to healthy controls on their risk-taking propensity after prior losses. Each participant played both the Balloon Analogue Risk Taking task (BART) and a modified version of the same task, where individuals face five repeated predetermined early losses at the onset of the game. No significant difference in risk-taking was found between groups on the standard BART task, while significant differences emerged when comparing behaviors in the two tasks: both pathological gamblers and controls reduced their risk-taking tendency after prior losses in the modified BART compared to the standard BART, whereas problem gamblers showed no reduction in risk-taking after prior losses. We interpret these results as a sign of a reduced sensitivity to negative feedback in problem gamblers which might contribute to explain their loss-chasing tendency.

Framing alters risk-taking behavior on a modified Balloon Analogue Risk Task (BART) in a sex-specific manner.

PubMed

Gabriel, Kara I; Williamson, Ashley

2010-12-01

Framing uncertain scenarios to emphasize potential positive or negative elements influences decision making and behavior. The current experiment investigated sex differences in framing effects on risk-taking propensity in a modified version of the Balloon Analogue Risk Task (BART). Male and female undergraduates completed questionnaires on sensation seeking, impulsiveness, and risk and benefit perception prior to viewing one of three framing conditions for the BART: (1) positively-framed instructions emphasizing the ability to earn money if balloons were inflated to large size; (2) negatively framed instructions emphasizing the possibility that money could be lost if balloons were inflated to bursting; and (3) completely framed instructions noting both possible outcomes. Results revealed correlations between BART performance and impulsiveness for both sexes. Compared to positive and complete framing, negatively framed instructions decreased balloon inflation time in women but not men, indicating sex differences in response to treatments designed to alter risk-taking behavior.

Noise Assessment of the Bay Area Rapid Transit System

DOT National Transportation Integrated Search

1978-10-01

The report describes the noise on and near the San Francisco Bay Area Rapid Transit System (BART). BART has approximately 75 miles of two-way revenue track (of which 19.7 miles are in subway) and 34 stations. Noise data is given for specific measurem...

A preliminary experimental investigation of peer influence on risk-taking among adolescent smokers and non-smokers.

PubMed

Cavalca, Eleonora; Kong, Grace; Liss, Thomas; Reynolds, Elizabeth K; Schepis, Ty S; Lejuez, C W; Krishnan-Sarin, Suchitra

2013-04-01

Epidemiological evidence suggests that peer influence plays a significant role in a variety of adolescent risk-taking behaviors, including tobacco use. We attempted to establish this relationship in a controlled laboratory setting. We modified the Balloon Analog Risk Task (BART) task to include a peer component to investigate whether peer influences alter risk-taking behaviors. Thirty-nine adolescents (22 smokers, 17 non-smokers) completed one experimental session during which the standard and peer BART were presented in counterbalanced order, with the dependent measures being adjusted mean number of pumps and explosions. We also examined the relationship of changes in the BART (standard-peer) to personality measures of impulsivity (BIS-11) and resistance to peer influence (RPI). A significant interaction of BART type and smoking status was present (p=.05); specifically smokers had a greater increase in the number of explosions by 2.27 (SD=3.12) compared to an increase of .29 (SD=2.87) by non-smokers. BIS-11 scores were related to peer-influenced BART changes: those who were more impulsive experienced greater changes in risk-taking, but no similar relationships were observed for the RPI. These results suggest that peer influences enhance risk-taking among adolescents, and that smokers may be more susceptible to these influences. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

The orifice revisited: women in gynaecological texts.

PubMed

Koutroulis, G

1990-01-01

A content analysis was carried out on obstetric and gynaecological textbooks recommended for medical students at four Australian universities. The texts were read for a hidden curriculum of sexist ideology. This study is a partial replication of a study carried out by Scully and Bart in the United States eighteen years ago. The findings of Scully and Bart demonstrated that obstetric and gynaecological texts contained outdated and erroneous views about women's sexuality and portrayed women in stereotyped roles. It was anticipated that institutionalized changes may have occurred since the time that Scully and Bart carried out their research and the texts would reflect this accordingly; particularly with the effect of the women's health movement which has been expressing dissatisfaction with the health care system. The findings of this research show that sexist ideology still pervades the obstetric and gynaecological texts, though to a lesser extent than eighteen years ago. There are some differences from what Scully and Bart discovered, but major similarities were found. The main difference between the results of this study and the findings of Scully and Bart, is that the majority of texts analysed here did not contain outdated and incorrect information about women's sexual response. For example, none of the texts refer to vaginal orgasm as the 'mature' response for women. The main similarity is that women's sexuality is still depicted with a heterosexual perspective, with marriage and mothering the 'natural' aspirations of all women.

77 FR 51739 - Approval and Promulgation of Implementation Plans; Tennessee; Regional Haze State Implementation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-27

... original Eastman BART determination and technical analysis provided in the State's April 4, 2008, SIP... EPA cannot read your comment due to technical difficulties and cannot contact you for clarification... the requirements for a BART alternative determination? III. What is EPA's analysis of Tennessee's May...

77 FR 70689 - Approval and Promulgation of Implementation Plans; Tennessee; Regional Haze State Implementation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-27

... Retrofit Technology Requirements for Eastman Chemical Company AGENCY: Environmental Protection Agency (EPA). ACTION: Final rule. SUMMARY: EPA is finalizing approval of the Best Available Retrofit Technology (BART... retrofitting its facility pursuant to the BART determination for SO 2 emissions (hereafter referred to as the...

Observations and Thermochemical Calculations for Hot-Jupiter Atmospheres

NASA Astrophysics Data System (ADS)

Blecic, Jasmina; Harrington, Joseph; Bowman, M. Oliver; Cubillos, Patricio; Stemm, Madison

2015-01-01

I present Spitzer eclipse observations for WASP-14b and WASP-43b, an open source tool for thermochemical equilibrium calculations, and components of an open source tool for atmospheric parameter retrieval from spectroscopic data. WASP-14b is a planet that receives high irradiation from its host star, yet, although theory does not predict it, the planet hosts a thermal inversion. The WASP-43b eclipses have signal-to-noise ratios of ~25, one of the largest among exoplanets. To assess these planets' atmospheric composition and thermal structure, we developed an open-source Bayesian Atmospheric Radiative Transfer (BART) code. My dissertation tasks included developing a Thermochemical Equilibrium Abundances (TEA) code, implementing the eclipse geometry calculation in BART's radiative transfer module, and generating parameterized pressure and temperature profiles so the radiative-transfer module can be driven by the statistical module.To initialize the radiative-transfer calculation in BART, TEA calculates the equilibrium abundances of gaseous molecular species at a given temperature and pressure. It uses the Gibbs-free-energy minimization method with an iterative Lagrangian optimization scheme. Given elemental abundances, TEA calculates molecular abundances for a particular temperature and pressure or a list of temperature-pressure pairs. The code is tested against the original method developed by White at al. (1958), the analytic method developed by Burrows and Sharp (1999), and the Newton-Raphson method implemented in the open-source Chemical Equilibrium with Applications (CEA) code. TEA, written in Python, is modular, documented, and available to the community via the open-source development site GitHub.com.Support for this work was provided by NASA Headquarters under the NASA Earth and Space Science Fellowship Program, grant NNX12AL83H, by NASA through an award issued by JPL/Caltech, and through the Science Mission Directorate's Planetary Atmospheres Program, grant NNX12AI69G.

78 FR 29292 - Partial Approval and Partial Disapproval of Air Quality State Implementation Plans; Arizona...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-20

... Technology (BART) controls for four sources. These sources are Freeport-McMoRan Incorporated (FMMI) Miami... Electric Power Cooperative (AEPCO) Apache Generating Station. However, we are proposing to disapprove other...) The initials BART mean or refer to Best Available Retrofit Technology. (5) The term Class I area...

77 FR 33021 - Approval, Disapproval and Promulgation of Implementation Plans; State of Wyoming; Regional Haze...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-04

... or refer to air-fuel ratio controls. iii. The initials BART mean or refer to Best Available Retrofit... install BART controls for the purpose of eliminating or reducing visibility impairment. The specific... retrofit controls at certain larger, often uncontrolled, older stationary sources in order to address...

76 FR 10530 - Supplemental Proposed Rule of Source Specific Federal Implementation Plan for Implementing Best...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-25

... proposed post-control BART limit of 0.012 lb/MMBtu on Units 1-3. C. Modeling and Demonstrating Reasonable... a different alternative emissions control strategy would achieve more progress than EPA's BART... Background for Proposing To Approve an Alternative Emissions Control Strategy as Achieving Better Progress...

77 FR 29270 - Approval and Promulgation of Implementation Plans; State of Montana; State Implementation Plan...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-17

... by Holcim for Trident Cement Plant, Three Forks, MT (``Holcim Initial Response'') (July 6, 2007); Responses to EPA comments on BART analysis for Trident Cement Plant (``Holcim 2008 Responses'') (Jan. 25, 2008); BART analysis by Holcim for low NO X burners for Trident Cement Plant (``Holcim Additional...

77 FR 38185 - Approval and Promulgation of Implementation Plans; State of North Carolina; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-27

... Transport Rule than BART; and EPA's proposed ``Better than BART'' determination relies on a 2014 base case... cannot be evaluated in isolation from one another. The Commenter supports its position by repeating... isolation from the reasonable progress requirements. We have on several occasions undertaken evaluations of...

40 CFR 52.2501 - Best available retrofit technology (BART) requirement for the Tesoro Refining and Marketing...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 5 2014-07-01 2014-07-01 false Best available retrofit technology... Best available retrofit technology (BART) requirement for the Tesoro Refining and Marketing Company oil... 10, to the following email address: [email protected] Effective Date Note: At 79 FR 33454...

40 CFR 52.985 - Visibility protection.

Code of Federal Regulations, 2014 CFR

2014-07-01

... requirements of 40 CFR 51.308(d)(3) and 51.308(e) with respect to emissions of NOX and SO2 from electric... for regional haze as it relies on deficient non-electric generating units Best Available Retrofit Technology (BART) analyses; and 40 CFR 51.308(e), BART requirements for regional haze visibility impairment...

40 CFR 52.985 - Visibility protection.

Code of Federal Regulations, 2013 CFR

2013-07-01

... requirements of 40 CFR 51.308(d)(3) and 51.308(e) with respect to emissions of NOX and SO2 from electric... for regional haze as it relies on deficient non-electric generating units Best Available Retrofit Technology (BART) analyses; and 40 CFR 51.308(e), BART requirements for regional haze visibility impairment...

Plasma viral microRNA profiles reveal potential biomarkers for chronic active Epstein-Barr virus infection.

PubMed

Kawano, Yoshihiko; Iwata, Seiko; Kawada, Jun-ichi; Gotoh, Kensei; Suzuki, Michio; Torii, Yuka; Kojima, Seiji; Kimura, Hiroshi; Ito, Yoshinori

2013-09-01

Chronic active Epstein-Barr virus (CAEBV) infection has high mortality and morbidity, and biomarkers for disease severity and prognosis are required. MicroRNAs (miRNAs) are small noncoding RNAs, and EBV encodes multiple miRNAs. Because plasma contains sufficiently stable miRNAs, circulating EBV-associated miRNA profiles were investigated as novel biomarkers in CAEBV infection. Plasma miRNA expression was assessed for 12 miRNAs encoded within 2 EBV open reading frames (BART and BHRF). Expression levels were investigated in 19 patients with CAEBV infection, 14 patients with infectious mononucleosis, and 11 healthy controls. Relative expression levels of plasma miRNAs were determined by TaqMan probe-based quantitative assay. Plasma miR-BART1-5p, 2-5p, 5, and 22 levels in patients with CAEBV infection were significantly greater than those in patients with infectious mononucleosis and in controls. Plasma miR-BART2-5p, 4, 7, 13, 15, and 22 levels were significantly elevated in patients with CAEBV infection with systemic symptoms, compared with levels in patients with no systemic symptoms. The levels of miR-BART2-5p, 13, and 15 showed clinical cutoff values associated with specific clinical conditions, in contrast to plasma EBV loads. Levels of specific plasma EBV miRNAs were elevated differentially in patients with CAEBV infection. Several EBV miRNAs, particularly miR-BART2-5p, 13, and 15, are potentially biomarkers of disease severity or prognosis.

CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells.

PubMed

Yuen, Kit-San; Chan, Chi-Ping; Wong, Nok-Hei Mickey; Ho, Chau-Ha; Ho, Ting-Hin; Lei, Ting; Deng, Wen; Tsao, Sai Wah; Chen, Honglin; Kok, Kin-Hang; Jin, Dong-Yan

2015-03-01

The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated 9) system is a highly efficient and powerful tool for RNA-guided editing of the cellular genome. Whether CRISPR/Cas9 can also cleave the genome of DNA viruses such as Epstein-Barr virus (EBV), which undergo episomal replication in human cells, remains to be established. Here, we reported on CRISPR/Cas9-mediated editing of the EBV genome in human cells. Two guide RNAs (gRNAs) were used to direct a targeted deletion of 558 bp in the promoter region of BART (BamHI A rightward transcript) which encodes viral microRNAs (miRNAs). Targeted editing was achieved in several human epithelial cell lines latently infected with EBV, including nasopharyngeal carcinoma C666-1 cells. CRISPR/Cas9-mediated editing of the EBV genome was efficient. A recombinant virus with the desired deletion was obtained after puromycin selection of cells expressing Cas9 and gRNAs. No off-target cleavage was found by deep sequencing. The loss of BART miRNA expression and activity was verified, supporting the BART promoter as the major promoter of BART RNA. Although CRISPR/Cas9-mediated editing of the multicopy episome of EBV in infected HEK293 cells was mostly incomplete, viruses could be recovered and introduced into other cells at low m.o.i. Recombinant viruses with an edited genome could be further isolated through single-cell sorting. Finally, a DsRed selectable marker was successfully introduced into the EBV genome during the course of CRISPR/Cas9-mediated editing. Taken together, our work provided not only the first genetic evidence that the BART promoter drives the expression of the BART transcript, but also a new and efficient method for targeted editing of EBV genome in human cells. © 2015 The Authors.

Ventricular Diastolic Function in Normal Fetuses and Fetuses with Hb Bart's Disease Assessed by Color M-Mode Propagation Velocity using Cardio-STIC-M (Spatio-Temporal Image Correlation M-Mode).

PubMed

Tongsong, T; Tongprasert, F; Srisupundit, K; Luewan, S; Traisrisilp, K

2016-10-01

Purpose: To determine whether ventricular diastolic dysfunction contributes to the pathogenesis of fetal cardiac failure due to fetal anemia using fetal Hb Bart's disease as a live model and cardio-STIC-M as a diagnostic tool. Materials and Methods: Color cardio-STIC volume datasets were acquired from fetuses at risk for Hb Bart's disease during 18 - 22 weeks of gestation and normal pregnancies and pregnancies with hydrops fetalis caused by Hb Bart's disease at 28 - 32 weeks. The volumes were analyzed off-line for velocity propagation (Vp) of the right and left ventricles to assess ventricular diastolic function using color cardio-STIC-M. Results: The Vp for the right and left ventricles was studied in fetuses at 18 - 22 weeks, including 64 normal fetuses (group 1) and 22 fetuses with Hb Bart's disease (group 2), and in fetuses at 28 - 32 weeks, including 22 normal fetuses (group 3) and 16 fetuses with Hb Bart's hydrops fetalis (group 4). The Vp of the fetuses in group 1 and group 2 was not significantly different. However, the Vp for the right and left ventricles in group 4 was significantly lower than in group 3 (19.02 vs. 9.78, p < 0.001; and 20.24 vs. 13.40, p < 0.001, respectively). The inter-observer variability had fair agreement with the intra-class correlation coefficient of 0.531 (95 % CI 0.393 - 0.646, p < 0.001). Conclusion: Hydrops fetalis secondary to fetal anemia is initially caused by hypervolemia rather than ventricular diastolic dysfunction while ventricular diastolic compromise is a late occurring consequence of persistent hypervolemia, different from the mechanism of hydropic changes caused by cardiac causes. © Georg Thieme Verlag KG Stuttgart · New York.

40 CFR Appendix Y to Part 51 - Guidelines for BART Determinations Under the Regional Haze Rule

Code of Federal Regulations, 2012 CFR

2012-07-01

... establishing BART emission limitations for fossil-fuel fired power plants having a capacity in excess of 750...: (1) Fossil-fuel fired steam electric plants of more than 250 million British thermal units (BTU) per...) Sintering plants, (20) Secondary metal production facilities, (21) Chemical process plants, (22) Fossil-fuel...

40 CFR Appendix Y to Part 51 - Guidelines for BART Determinations Under the Regional Haze Rule

Code of Federal Regulations, 2014 CFR

2014-07-01

... establishing BART emission limitations for fossil-fuel fired power plants having a capacity in excess of 750...: (1) Fossil-fuel fired steam electric plants of more than 250 million British thermal units (BTU) per...) Sintering plants, (20) Secondary metal production facilities, (21) Chemical process plants, (22) Fossil-fuel...

40 CFR Appendix Y to Part 51 - Guidelines for BART Determinations Under the Regional Haze Rule

Code of Federal Regulations, 2011 CFR

2011-07-01

... establishing BART emission limitations for fossil-fuel fired power plants having a capacity in excess of 750...: (1) Fossil-fuel fired steam electric plants of more than 250 million British thermal units (BTU) per...) Sintering plants, (20) Secondary metal production facilities, (21) Chemical process plants, (22) Fossil-fuel...

40 CFR Appendix Y to Part 51 - Guidelines for BART Determinations Under the Regional Haze Rule

Code of Federal Regulations, 2010 CFR

2010-07-01

... establishing BART emission limitations for fossil-fuel fired power plants having a capacity in excess of 750...: (1) Fossil-fuel fired steam electric plants of more than 250 million British thermal units (BTU) per...) Sintering plants, (20) Secondary metal production facilities, (21) Chemical process plants, (22) Fossil-fuel...

40 CFR Appendix Y to Part 51 - Guidelines for BART Determinations Under the Regional Haze Rule

Code of Federal Regulations, 2013 CFR

2013-07-01

... establishing BART emission limitations for fossil-fuel fired power plants having a capacity in excess of 750...: (1) Fossil-fuel fired steam electric plants of more than 250 million British thermal units (BTU) per...) Sintering plants, (20) Secondary metal production facilities, (21) Chemical process plants, (22) Fossil-fuel...

77 FR 42833 - Approval, Disapproval and Promulgation of Air Quality Implementation Plans; Arizona; Regional...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-20

... the problem of visibility impairment in Class I areas, states, or the EPA when implementing a FIP... explanation and rationale for its determinations. While we find these problems in all of ADEQ's BART analyses... problems resulted in control determinations that are inconsistent with the RHR and the BART Guidelines. We...

Indianapolis Mayor Bart Peterson: The Peyton Manning of Charter Schools

ERIC Educational Resources Information Center

Skinner, David

2007-01-01

Indianapolis Mayor Bart Peterson has laid down a bold challenge to the city's troubled public school system: improve or see your students migrate to the city's growing roster of impressive charter schools. This is no idle threat. In the 2006-2007 academic year, the mayor oversaw 16 charter schools serving 3,870 students. Peterson is currently the…

Comments in defense of symposia proceedings: Response to Bart and Anderson

Treesearch

Deborah M. Finch; A. Lorin Ward; R. H. Hamre

1982-01-01

A recent "Opinion" in the Wildlife Society Bulletin (Bart and Anderson 1981) made a case against publishing symposia proceedings because (1) papers of non-refereed symposia often lack credibility and, therefore, harm both the authors and the profession, (2) proceedings are not readily retrievable, and (3) some symposium reports are not appropriate for...

78 FR 62509 - Approval of Air Quality Implementation Plans; Navajo Nation; Regional Haze Requirements for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-22

... Retrofit Technology (BART) provision of the Clean Air Act (CAA or Act). EPA proposed the BART FIP to reduce... included in the proposal due to the unique purpose and history of NGS and the numerous stakeholder... Use I. National Technology Transfer and Advancement Act J. Executive Order 12898: Federal Actions To...

Risk-taking and alcohol use disorders symptomatology in a sample of problem drinkers.

PubMed

Ashenhurst, James R; Jentsch, J David; Ray, Lara A

2011-10-01

The relationship between risk-taking behavior and alcohol use disorder (AUD) symptoms is poorly understood. This study employed a modified version of a behavioral measure of risk-taking, the Balloon Analogue Risk Task (BART), to examine its relationship to alcohol use and related symptoms in a community sample of individuals with or at risk for AUD. A total of 158 (71.9% male) participants completed a testing battery that included the BART, a structured diagnostic interview for AUD, and measures of alcohol use and related problems. Estimates of IQ and working memory were assessed as covariates. Results indicated that the relationship between risk-taking propensity, as assessed by the BART, and alcohol problems was significant and negative. Individuals with higher symptom count made fewer pumps per trial on the BART, indicating less risk-taking. It is important to note that this relationship was attenuated when controlling for estimated IQ and working memory span. Further examination demonstrated that IQ and age mediated the relationship between risk-taking propensity and symptom count. The main negative relationship observed between risk-taking on the BART and alcohol use and AUD symptomatology in this sample stands in contrast to the positive relationships observed in adolescent and nonclinical samples. Together, these findings highlight the need to consider development and the course of addiction to fully elucidate the effects of risky-decision making on AUD liability. Furthermore, our results demonstrate the importance of inclusion of neurocognitive covariates (IQ), as well as demographic variables (age) when using this task.

Familial leuconychia, knuckle pads, hearing loss, and palmoplantar hyperkeratosis: an additional family with Bart-Pumphrey syndrome.

PubMed

Ramer, J C; Vasily, D B; Ladda, R L

1994-01-01

A family with five members who have variable findings of leuconychia, knuckle pads, hearing loss, and palmoplantar hyperkeratosis is described. The findings in these subjects are compared with those noted in previously reported patients with Bart-Pumphrey syndrome. The range of disorders which include knuckle pads as part of the phenotype is reviewed.

Semantics versus Statistics in the Retreat from Locative Overgeneralization Errors

ERIC Educational Resources Information Center

Ambridge, Ben; Pine, Julian M.; Rowland, Caroline F.

2012-01-01

The present study investigated how children learn that some verbs may appear in the figure-locative but not the ground-locative construction (e.g., "Lisa poured water into the cup"; "*Lisa poured the cup with water"), with some showing the opposite pattern (e.g., "*Bart filled water into the cup"; "Bart filled the cup with water"), and others…

Racial Differences in Risk-Taking Propensity on the Youth Version of the Balloon Analogue Risk Task (BART-Y)

ERIC Educational Resources Information Center

Collado, Anahi; Risco, Cristina M.; Banducci, Anne N.; Chen, Kevin W.; MacPherson, Laura; Lejuez, Carl W.

2017-01-01

Research indicates that White adolescents tend to engage in greater levels of risk behavior relative to Black adolescents. To better understand these differences, the current study examined real-time changes in risk-taking propensity (RTP). The study utilized the Balloon Analogue Risk Task-Youth Version (BART-Y), a well-validated real-time,…

Targeting the Ca(2+) Sensor STIM1 by Exosomal Transfer of Ebv-miR-BART13-3p is Associated with Sjögren's Syndrome.

PubMed

Gallo, Alessia; Jang, Shyh-Ing; Ong, Hwei Ling; Perez, Paola; Tandon, Mayank; Ambudkar, Indu; Illei, Gabor; Alevizos, Ilias

2016-08-01

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease that is associated with inflammation and dysfunction of salivary and lacrimal glands. The molecular mechanism(s) underlying this exocrinopathy is not known, although the syndrome has been associated with viruses, such as the Epstein Barr Virus (EBV). We report herein that an EBV-specific microRNA (ebv-miR-BART13-3p) is significantly elevated in salivary glands (SGs) of pSS patients and we show that it targets stromal interacting molecule 1 (STIM1), a primary regulator of the store-operated Ca(2+) entry (SOCE) pathway that is essential for SG function, leading to loss of SOCE and Ca(2+)-dependent activation of NFAT. Although EBV typically infects B cells and not salivary epithelial cells, ebv-miR-BART13-3p is present in both cell types in pSS SGs. Importantly, we further demonstrate that ebv-miR-BART13-3p can be transferred from B cells to salivary epithelial cells through exosomes and it recapitulates its functional effects on calcium signaling in a model system. Published by Elsevier B.V.

Familial leuconychia, knuckle pads, hearing loss, and palmoplantar hyperkeratosis: an additional family with Bart-Pumphrey syndrome.

PubMed Central

Ramer, J C; Vasily, D B; Ladda, R L

1994-01-01

A family with five members who have variable findings of leuconychia, knuckle pads, hearing loss, and palmoplantar hyperkeratosis is described. The findings in these subjects are compared with those noted in previously reported patients with Bart-Pumphrey syndrome. The range of disorders which include knuckle pads as part of the phenotype is reviewed. Images PMID:8151643

Epstein-Barr Virus MicroRNA miR-BART20-5p Suppresses Lytic Induction by Inhibiting BAD-Mediated caspase-3-Dependent Apoptosis

PubMed Central

Kim, Hyoji; Choi, Hoyun

2015-01-01

ABSTRACT Epstein-Barr virus (EBV) is a human gammaherpesvirus associated with a variety of tumor types. EBV can establish latency or undergo lytic replication in host cells. In general, EBV remains latent in tumors and expresses a limited repertoire of latent proteins to avoid host immune surveillance. When the lytic cycle is triggered by some as-yet-unknown form of stimulation, lytic gene expression and progeny virus production commence. Thus far, the exact mechanism of EBV latency maintenance and the in vivo triggering signal for lytic induction have yet to be elucidated. Previously, we have shown that the EBV microRNA miR-BART20-5p directly targets the immediate early genes BRLF1 and BZLF1 as well as Bcl-2-associated death promoter (BAD) in EBV-associated gastric carcinoma. In this study, we found that both mRNA and protein levels of BRLF1 and BZLF1 were suppressed in cells following BAD knockdown and increased after BAD overexpression. Progeny virus production was also downregulated by specific knockdown of BAD. Our results demonstrated that caspase-3-dependent apoptosis is a prerequisite for BAD-mediated EBV lytic cycle induction. Therefore, our data suggest that miR-BART20-5p plays an important role in latency maintenance and tumor persistence of EBV-associated gastric carcinoma by inhibiting BAD-mediated caspase-3-dependent apoptosis, which would trigger immediate early gene expression. IMPORTANCE EBV has an ability to remain latent in host cells, including EBV-associated tumor cells hiding from immune surveillance. However, the exact molecular mechanisms of EBV latency maintenance remain poorly understood. Here, we demonstrated that miR-BART20-5p inhibited the expression of EBV immediate early genes indirectly, by suppressing BAD-induced caspase-3-dependent apoptosis, in addition to directly, as we previously reported. Our study suggests that EBV-associated tumor cells might endure apoptotic stress to some extent and remain latent with the aid of miR-BART20-5p. Blocking the expression or function of BART20-5p may expedite EBV-associated tumor cell death via immune attack and apoptosis. PMID:26581978

Rapid detection of Salmonella in food and feed by coupling loop-mediated isothermal amplification with bioluminescent assay in real-time.

PubMed

Yang, Qianru; Domesle, Kelly J; Wang, Fei; Ge, Beilei

2016-06-17

Salmonella is among the most significant pathogens causing food and feed safety concerns. This study examined the rapid detection of Salmonella in various types of food and feed samples by coupling loop-mediated isothermal amplification (LAMP) with a novel reporter, bioluminescent assay in real-time (BART). Performance of the LAMP-BART assay was compared to a conventional LAMP and the commercially available 3M Molecular Detection Assay (MDA) Salmonella. The LAMP-BART assay was 100 % specific among 178 strains (151 Salmonella and 27 non-Salmonella) tested. The detection limits were 36 cells per reaction in pure culture and 10(4) to 10(6) CFU per 25 g in spiked food and feed samples without enrichment, which were comparable to those of the conventional LAMP and 3M MDA Salmonella but 5-10 min faster. Ground turkey showed a strong inhibition on 3M MDA Salmonella, requiring at least 10(8) CFU per 25 g for detection. The correlation between Salmonella cell numbers and LAMP-BART signals was high (R (2) = 0.941-0.962), suggesting good quantification capability. After 24 h enrichment, all three assays accurately detected 1 to 3 CFU per 25 g of Salmonella among five types of food (cantaloupe, ground beef, ground turkey, shell eggs, and tomato) and three types of feed (cattle feed, chicken feed, and dry dog food) examined. However, 10(1) CFU per 25 g was required for cattle feed when tested by 3M MDA Salmonella. The Salmonella LAMP-BART assay was rapid, specific, sensitive, quantitative, and robust. Upon further validation, it may become a valuable tool for routine screening of Salmonella in various types of food and feed samples.

Adolescent Balloon Analog Risk Task and Behaviors that Influence Risk of Motor Vehicle Crash Injury

PubMed Central

Vaca, Federico E.; Walthall, Jessica M.; Ryan, Sheryl; Moriarty-Daley, Alison; Riera, Antonio; Crowley, Michael J.; Mayes, Linda C.

2013-01-01

Risk-taking propensity is a pivotal facet of motor vehicle crash involvement and subsequent traumatic injury in adolescents. Clinical encounters are important opportunities to identify teens with high risk-taking propensity who may later experience serious injury. Our objective was to compare self-reports of health risk behavior with performance on the Balloon Analog Risk Task (BART), a validated metric of risk-taking propensity, in adolescents during a clinical encounter. 100 adolescent patients from a hospital emergency department and adolescent health clinic completed a computer-based survey of self-reported risk behaviors including substance use behaviors and behaviors that influence crash involvement. They then completed the BART, a validated laboratory-based risk task in which participants earn points by pumping up a computer-generated balloon with greater pumps leading to increased chance of balloon explosion. 20 trials were undertaken. Mean number of pumps on the BART showed a correlation of .243 (p=.015) with self-reported driver/passenger behaviors and attitudes towards driving that influence risk of crash injury. Regression analyses showed that self-reports of substance use and mean number of pumps on the BART uniquely predict self-reports of behaviors influencing the risk of crash injury. The BART is a promising correlate of real-world risk-taking behavior related to traffic safety. It remains a valid predictor of behaviors influencing risk of crash injury when using just 10 trials, suggesting its utility as a quick and effective screening measure for use in busy clinical environments. This tool may be an important link to prevention interventions for those most at-risk for future motor vehicle crash involvement and injury. PMID:24406948

Differences in neural activation as a function of risk-taking task parameters.

PubMed

Congdon, Eliza; Bato, Angelica A; Schonberg, Tom; Mumford, Jeanette A; Karlsgodt, Katherine H; Sabb, Fred W; London, Edythe D; Cannon, Tyrone D; Bilder, Robert M; Poldrack, Russell A

2013-01-01

Despite evidence supporting a relationship between impulsivity and naturalistic risk-taking, the relationship of impulsivity with laboratory-based measures of risky decision-making remains unclear. One factor contributing to this gap in our understanding is the degree to which different risky decision-making tasks vary in their details. We conducted an fMRI investigation of the Angling Risk Task (ART), which is an improved behavioral measure of risky decision-making. In order to examine whether the observed pattern of neural activation was specific to the ART or generalizable, we also examined correlates of the Balloon Analog Risk Taking (BART) task in the same sample of 23 healthy adults. Exploratory analyses were conducted to examine the relationship between neural activation, performance, impulsivity and self-reported risk-taking. While activation in a valuation network was associated with reward tracking during the ART but not the BART, increased fronto-cingulate activation was seen during risky choice trials in the BART as compared to the ART. Thus, neural activation during risky decision-making trials differed between the two tasks, and this observation was likely driven by differences in task parameters, namely the absence vs. presence of ambiguity and/or stationary vs. increasing probability of loss on the ART and BART, respectively. Exploratory association analyses suggest that sensitivity of neural response to the magnitude of potential reward during the ART was associated with a suboptimal performance strategy, higher scores on a scale of dysfunctional impulsivity (DI) and a greater likelihood of engaging in risky behaviors, while this pattern was not seen for the BART. Our results suggest that the ART is decomposable and associated with distinct patterns of neural activation; this represents a preliminary step toward characterizing a behavioral measure of risky decision-making that may support a better understanding of naturalistic risk-taking.

The Balloon Analog Insurance Task (BAIT): A Behavioral Measure of Protective Risk Management

PubMed Central

Essex, Brian G.; Lejuez, Carl W.; Qian, Rebecca Y.; Bernstein, Katherine; Zald, David H.

2011-01-01

Prior methods used to assess individual differences related to risk have not focused on an important component of risk management: how willing individuals are to pay for or take actions to insure what they already have. It is not clear whether this type of protective risk management taps into the same individual differences as does risk taking propensity measured by existing risk taking tasks. We developed a novel task to assess protective risk management, the Balloon Analog Insurance Task (BAIT), which is modeled after the Balloon Analog Risk Task (BART). In the BAIT, individuals are forced to decide how much money they are willing to pay in order to insure a specific fraction of their prior winnings given changing but imprecise levels of risk of monetary loss. Participants completed the BART and BAIT for real monetary rewards, and completed six self report questionnaires. The amount of insurance purchased on the BAIT was positively correlated with scores on the Intolerance of Uncertainty Scale and on the Checking scale of the revised Obsessive Compulsive Inventory. Conversely, the amount of insurance purchased was negatively correlated with scores on the Domain Specific Risk Taking Questionnaire, and on the Psychopathic Personality Inventory (PPI). Furthermore, relationships between insurance purchased and these scales remained significant after controlling for the BART in linear regression analyses, and the BART was only a significant predictor for measures on one scale - the PPI. Our results reveal that behavior on the BAIT taps into a number of individual differences that are not related to behavior on another measure of risk taking. We propose that the BAIT may provide a useful complement to the BART in the assessment of risk management style. PMID:21738666

The Balloon Analog Insurance Task (BAIT): a behavioral measure of protective risk management.

PubMed

Essex, Brian G; Lejuez, Carl W; Qian, Rebecca Y; Bernstein, Katherine; Zald, David H

2011-01-01

Prior methods used to assess individual differences related to risk have not focused on an important component of risk management: how willing individuals are to pay for or take actions to insure what they already have. It is not clear whether this type of protective risk management taps into the same individual differences as does risk taking propensity measured by existing risk taking tasks. We developed a novel task to assess protective risk management, the Balloon Analog Insurance Task (BAIT), which is modeled after the Balloon Analog Risk Task (BART). In the BAIT, individuals are forced to decide how much money they are willing to pay in order to insure a specific fraction of their prior winnings given changing but imprecise levels of risk of monetary loss. Participants completed the BART and BAIT for real monetary rewards, and completed six self report questionnaires. The amount of insurance purchased on the BAIT was positively correlated with scores on the Intolerance of Uncertainty Scale and on the Checking scale of the revised Obsessive Compulsive Inventory. Conversely, the amount of insurance purchased was negatively correlated with scores on the Domain Specific Risk Taking Questionnaire, and on the Psychopathic Personality Inventory (PPI). Furthermore, relationships between insurance purchased and these scales remained significant after controlling for the BART in linear regression analyses, and the BART was only a significant predictor for measures on one scale--the PPI. Our results reveal that behavior on the BAIT taps into a number of individual differences that are not related to behavior on another measure of risk taking. We propose that the BAIT may provide a useful complement to the BART in the assessment of risk management style.

Routine screening for α-thalassaemia using an immunochromatographic strip assay for haemoglobin Bart's.

PubMed

Prayalaw, Patcharawadee; Fucharoen, Goonnapa; Fucharoen, Supan

2014-09-01

To evaluate an immunochromatographic (IC) strip assay for Hb Bart's as a routine screening test for α-thalassaemia in area with a high prevalence of thalassaemia and haemoglobinopathies. A total of 300 adult screen positive blood specimens were collected at an ongoing thalassaemia screening programme in northeast Thailand. Routine screening was done using red blood cell indices, osmotic fragility, and dichlorophenolindophenol tests. The IC strip assay for haemoglobin Bart's was performed on all samples. The result was evaluated against thalassaemia genotypes determined using standard haemoglobin and DNA analyses. Of 300 subjects investigated, Hb and DNA analyses identified 32 with normal genotype. The remaining subjects carried thalassaemia with as many as 16 different genotypes. Hb Bart's was detected in all cases, with several α(0)-thalassaemia (SEA type) related disorders. Of cases with α(+)-thalassaemia, 86.1% showed a positive result; 100 out of 103 Hb E carriers, all homozygous Hb E and β-thalassaemia trait were negative. Nine out of 17 cases with β-thalassaemia/Hb E disease, and one case of double heterozygote for Hb Q-Thailand and Hb E returned positive results. The overall sensitivity and specificity of the IC strip assay for detecting α(0)-thalassaemia were 100% and 73.1%, respectively. The results showed a high sensitivity for screening for α(0)-thalassaemia using IC strip assay for Hb Bart's. This simple method, used in combination with conventional screening protocols, should lead to a significant reduction in the number of referral cases for DNA analysis. Cost effectiveness in each population should be taken into consideration. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

Plasma EBV microRNAs in paediatric renal transplant recipients.

PubMed

Hassan, Jaythoon; Dean, Jonathan; De Gascun, Cillian F; Riordan, Michael; Sweeney, Clodagh; Connell, Jeff; Awan, Atif

2018-06-01

Epstein-Barr virus (EBV) was the first human virus identified to express microRNA (miRNA). To date, 44 mature miRNAs are encoded for within the EBV genome. EBV miRNAs have not been profiled in paediatric renal transplant recipients. In this study, we investigated circulating EBV miRNA profiles as novel biomarkers in paediatric renal transplant patients. Forty-two microRNAs encoded within 2 EBV open reading frames (BART and BHRF) were examined in renal transplant recipients who resolved EBV infection (REI) or maintained chronic high viral loads (CHL), and in non-transplant patients with acute infectious mononucleosis (IM). Plasma EBV-miR-BART2-5p was present in higher numbers of IM (7/8) and CHL (7/10) compared to REI (7/12) patients. A trend was observed between the numbers of plasma EBV miRNAs expressed and EBV viral load (p < 0.07). Several EBV-miRs including BART7-3p, 15, 9-3p, 11-3p, 1-3p and 3-3p were detected in IM and CHL patients only. The lytic EBV-miRs, BHRF1-2-3p and 1-1, indicating active viral replication, were detected in IM patients only. One CHL patient developed post-transplant lymphoproliferative disease (PTLD) after several years and analysis of 10 samples over a 30-month period showed an average 24-fold higher change in plasma EBV-miR-BART2-5p compared to the CHL group and 110-fold higher change compared to the REI group. Our results suggest that EBV-miR-BART2-5p, which targets the stress-induced immune ligand MICB to escape recognition and elimination by NK cells, may have a role in sustaining high EBV viral loads in CHL paediatric kidney transplant recipients.

A Search for new particles decaying into top quark anti-top quark pairs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cassada, Josh Aaron

2000-01-01

We use 106 pb -1 of data collected with the Collider Detector at Fermilab to search for narrow-width particles decaying to a top and an anti-top quark. We measure the tmore » $$\\bar{t}$$ invariant mass distribution by requiring that either t or $$\\bar{t}$$ decays semileptonically to an electron or muon and the other decays hadronically.« less

Emerging Roles of Small Epstein-Barr Virus Derived Non-Coding RNAs in Epithelial Malignancy

PubMed Central

Lung, Raymond Wai-Ming; Tong, Joanna Hung-Man; To, Ka-Fai

2013-01-01

Latent Epstein-Barr virus (EBV) infection is an etiological factor in the progression of several human epithelial malignancies such as nasopharyngeal carcinoma (NPC) and a subset of gastric carcinoma. Reports have shown that EBV produces several viral oncoproteins, yet their pathological roles in carcinogenesis are not fully elucidated. Studies on the recently discovered of EBV-encoded microRNAs (ebv-miRNAs) showed that these small molecules function as post-transcriptional gene regulators and may play a role in the carcinogenesis process. In NPC and EBV positive gastric carcinoma (EBVaGC), 22 viral miRNAs which are located in the long alternative splicing EBV transcripts, named BamH1 A rightward transcripts (BARTs), are abundantly expressed. The importance of several miR-BARTs in carcinogenesis has recently been demonstrated. These novel findings enhance our understanding of the oncogenic properties of EBV and may lead to a more effective design of therapeutic regimens to combat EBV-associated malignancies. This article will review the pathological roles of miR-BARTs in modulating the expression of cancer-related genes in both host and viral genomes. The expression of other small non-coding RNAs in NPC and the expression pattern of miR-BARTs in rare EBV-associated epithelial cancers will also be discussed. PMID:23979421

Using the North American Breeding Bird Survey as a tool for conservation: A critique of Bart et al. (2004)

USGS Publications Warehouse

Sauer, John R.; Link, William A.; Nichols, James D.; Royle, J. Andrew

2005-01-01

Bart et al. (2004) develop methods for predicting needed samples for estimation of long-term trends from Count survey data, and they apply these methods to the North American Breeding Bird Survey (BBS). They recommend adding approximately 40% more survey routes ill the BBS to allow for estimation of long-term (i.e., 20 year) trends for a collection of species. We critique several aspects of their analysis and suggest that their focus on long-term trends and expansion of the present survey design will provide limited benefits for conservation because it fails to either enhance the credibility of the survey or better tie the survey to regional management activities. A primary innovation claimed by Bart et al. (2004) is the incorporation of bias in estimation of study planning. We question the value of this approach, as it requires reliable estimates of range of future bias. We show that estimates of bias used by Bart et al. (2004) are speculative. Failure to obtain better estimates of this bias is likely to compromise the credibility of future analyses of the survey. We also note that the generic analysis of population trends that they provide is of questionable validity and is unlikely to be relevant for regions and species of management concern.

A further assessment of decision-making in anorexia nervosa.

PubMed

Adoue, C; Jaussent, I; Olié, E; Beziat, S; Van den Eynde, F; Courtet, P; Guillaume, S

2015-01-01

Anorexia nervosa (AN) may be associated with impaired decision-making. Cognitive processes underlying this impairment remain unclear, mainly because previous assessments of this complex cognitive function were completed with a single test. Furthermore, clinical features such as mood status may impact this association. We aim to further explore the hypothesis of altered decision-making in AN. Sixty-three adult women with AN and 49 female controls completed a clinical assessment and were assessed by three tasks related to decision-making [Iowa Gambling Task (IGT), Balloon Analogue Risk Task (BART), Probabilistic Reversal Learning Task (PRLT)]. People with AN had poorer performance on the IGT and made less risky choices on the BART, whereas performances were not different on PRLT. Notably, AN patients with a current major depressive disorder showed similar performance to those with no current major depressive disorder. These results tend to confirm an impaired decision making-process in people with AN and suggest that various cognitive processes such as inhibition to risk-taking or intolerance of uncertainty may underlie this condition Furthermore, these impairments seem unrelated to the potential co-occurent major depressive disorders. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Energy storage and alternatives to improve train voltage on a mass transit system

NASA Astrophysics Data System (ADS)

Gordon, S. P.; Rorke, W. S.

1995-04-01

The wide separation of substations in the Bay Area Rapid Transit system's transbay tunnel contributes to voltage sag when power demand is high. In the future, expansions to the system will exacerbate this problem by increasing traffic density. Typically, this situation is remedied through the installation of additional substations to increase the system's power capacity. We have evaluated the efficacy of several alternatives to this approach - specifically, installation of an 8 megajoule energy storage system, modification of the existing substations, or reduction of the resistance of the running rails or the third rail. To support this analysis, we have developed a simple model of the traction power system in the tunnel. We have concluded that the storage system does not have sufficient capacity to deal with the expected voltage sags; in this application, the alternatives present more effective solutions. We have also investigated the potential impact of these system upgrades on expected future capital outlays by BART for traction power infrastructure additions. We have found that rail or substation upgrades may reduce the need for additional substations. These upgrades may also be effective on other parts of the BART system and on other traction power systems.

Epstein-Barr Virus MicroRNA miR-BART20-5p Suppresses Lytic Induction by Inhibiting BAD-Mediated caspase-3-Dependent Apoptosis.

PubMed

Kim, Hyoji; Choi, Hoyun; Lee, Suk Kyeong

2016-02-01

Epstein-Barr virus (EBV) is a human gammaherpesvirus associated with a variety of tumor types. EBV can establish latency or undergo lytic replication in host cells. In general, EBV remains latent in tumors and expresses a limited repertoire of latent proteins to avoid host immune surveillance. When the lytic cycle is triggered by some as-yet-unknown form of stimulation, lytic gene expression and progeny virus production commence. Thus far, the exact mechanism of EBV latency maintenance and the in vivo triggering signal for lytic induction have yet to be elucidated. Previously, we have shown that the EBV microRNA miR-BART20-5p directly targets the immediate early genes BRLF1 and BZLF1 as well as Bcl-2-associated death promoter (BAD) in EBV-associated gastric carcinoma. In this study, we found that both mRNA and protein levels of BRLF1 and BZLF1 were suppressed in cells following BAD knockdown and increased after BAD overexpression. Progeny virus production was also downregulated by specific knockdown of BAD. Our results demonstrated that caspase-3-dependent apoptosis is a prerequisite for BAD-mediated EBV lytic cycle induction. Therefore, our data suggest that miR-BART20-5p plays an important role in latency maintenance and tumor persistence of EBV-associated gastric carcinoma by inhibiting BAD-mediated caspase-3-dependent apoptosis, which would trigger immediate early gene expression. EBV has an ability to remain latent in host cells, including EBV-associated tumor cells hiding from immune surveillance. However, the exact molecular mechanisms of EBV latency maintenance remain poorly understood. Here, we demonstrated that miR-BART20-5p inhibited the expression of EBV immediate early genes indirectly, by suppressing BAD-induced caspase-3-dependent apoptosis, in addition to directly, as we previously reported. Our study suggests that EBV-associated tumor cells might endure apoptotic stress to some extent and remain latent with the aid of miR-BART20-5p. Blocking the expression or function of BART20-5p may expedite EBV-associated tumor cell death via immune attack and apoptosis. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

ε-Aminocaproic acid and clinical value in cardiac anesthesia.

PubMed

Raghunathan, Karthik; Connelly, Neil Roy; Kanter, Gary J

2011-02-01

The primary aim was to compare the "clinical value" of tranexamic acid (TXA) with ε-aminocaproic acid (EACA) when used for blood conservation during high-risk cardiac surgery. Data previously reported by the Blood Conservation Using Antifibrinolytics in a Randomized Trial (BART) study investigators were reanalyzed independently after appropriate statistical adjustment. The authors compared TXA with EACA for important primary and secondary outcomes and applied the "clinical value" equation to this comparison. BART, the largest blinded multicenter study on this topic to date, compared all 3 commonly used antifibrinolytics head-to-head in a randomized dose-equivalent fashion during high-risk cardiac surgery. Comparisons of TXA with EACA with application of the clinical value equation was not performed specifically by the BART investigators. One thousand five hundred fifty patients enrolled in 2 of the 3 arms of the BART study were included in the analysis (TXA, n= 770 and EACA, n = 780, with data reported by the investigators in the New England Journal of Medicine). The major finding was that there were no significant differences in overall safety and clinically important efficacy between TXA and EACA. Considering the substantial difference in costs and with the increasing volume of high-risk cardiac surgery, EACA has increased "clinical value" when compared with TXA. EACA should be the antifibrinolytic medication of choice for high-risk cardiac surgery. Copyright © 2011 Elsevier Inc. All rights reserved.

Differences in neural activation as a function of risk-taking task parameters

PubMed Central

Congdon, Eliza; Bato, Angelica A.; Schonberg, Tom; Mumford, Jeanette A.; Karlsgodt, Katherine H.; Sabb, Fred W.; London, Edythe D.; Cannon, Tyrone D.; Bilder, Robert M.; Poldrack, Russell A.

2013-01-01

Despite evidence supporting a relationship between impulsivity and naturalistic risk-taking, the relationship of impulsivity with laboratory-based measures of risky decision-making remains unclear. One factor contributing to this gap in our understanding is the degree to which different risky decision-making tasks vary in their details. We conducted an fMRI investigation of the Angling Risk Task (ART), which is an improved behavioral measure of risky decision-making. In order to examine whether the observed pattern of neural activation was specific to the ART or generalizable, we also examined correlates of the Balloon Analog Risk Taking (BART) task in the same sample of 23 healthy adults. Exploratory analyses were conducted to examine the relationship between neural activation, performance, impulsivity and self-reported risk-taking. While activation in a valuation network was associated with reward tracking during the ART but not the BART, increased fronto-cingulate activation was seen during risky choice trials in the BART as compared to the ART. Thus, neural activation during risky decision-making trials differed between the two tasks, and this observation was likely driven by differences in task parameters, namely the absence vs. presence of ambiguity and/or stationary vs. increasing probability of loss on the ART and BART, respectively. Exploratory association analyses suggest that sensitivity of neural response to the magnitude of potential reward during the ART was associated with a suboptimal performance strategy, higher scores on a scale of dysfunctional impulsivity (DI) and a greater likelihood of engaging in risky behaviors, while this pattern was not seen for the BART. Our results suggest that the ART is decomposable and associated with distinct patterns of neural activation; this represents a preliminary step toward characterizing a behavioral measure of risky decision-making that may support a better understanding of naturalistic risk-taking. PMID:24137106

Extensions and applications of ensemble-of-trees methods in machine learning

NASA Astrophysics Data System (ADS)

Bleich, Justin

Ensemble-of-trees algorithms have emerged to the forefront of machine learning due to their ability to generate high forecasting accuracy for a wide array of regression and classification problems. Classic ensemble methodologies such as random forests (RF) and stochastic gradient boosting (SGB) rely on algorithmic procedures to generate fits to data. In contrast, more recent ensemble techniques such as Bayesian Additive Regression Trees (BART) and Dynamic Trees (DT) focus on an underlying Bayesian probability model to generate the fits. These new probability model-based approaches show much promise versus their algorithmic counterparts, but also offer substantial room for improvement. The first part of this thesis focuses on methodological advances for ensemble-of-trees techniques with an emphasis on the more recent Bayesian approaches. In particular, we focus on extensions of BART in four distinct ways. First, we develop a more robust implementation of BART for both research and application. We then develop a principled approach to variable selection for BART as well as the ability to naturally incorporate prior information on important covariates into the algorithm. Next, we propose a method for handling missing data that relies on the recursive structure of decision trees and does not require imputation. Last, we relax the assumption of homoskedasticity in the BART model to allow for parametric modeling of heteroskedasticity. The second part of this thesis returns to the classic algorithmic approaches in the context of classification problems with asymmetric costs of forecasting errors. First we consider the performance of RF and SGB more broadly and demonstrate its superiority to logistic regression for applications in criminology with asymmetric costs. Next, we use RF to forecast unplanned hospital readmissions upon patient discharge with asymmetric costs taken into account. Finally, we explore the construction of stable decision trees for forecasts of violence during probation hearings in court systems.

The effect of EBV on WIF1, NLK, and APC gene methylation and expression in gastric carcinoma and nasopharyngeal cancer.

PubMed

Zhao, Zhenzhen; Liu, Wen; Liu, Jincheng; Wang, Jiayi; Luo, Bing

2017-10-01

Epstein-Barr virus (EBV) is an important DNA tumor virus that is associated with approximately 10% of gastric carcinomas and 99% of nasopharyngeal cancers (NPC). DNA methylation and microRNAs (miRNAs) are the most studied epigenetic mechanisms that can prompt disease susceptibility. This study aimed to detect the effect of EBV on Wnt inhibitory factor 1 (WIF1), Nemo-like kinase (NLK), and adenomatous polyposis coli (APC) gene methylation, and expression in gastric carcinoma and NPC. The WIF1, NLK, and APC gene mRNA expression levels were measured by real-time quantitative RT-PCR in four EBV-positive cell lines and four EBV-negative cell lines. Bisulfite genomic sequencing or methylation-specific PCR was used to detect the methylation status of the WIF1, NLK, and APC promoters. All cell lines were treated with 5-azacytidine (5-aza-dC), miR-BART19-3p mimics or an inhibitor, and analyzed by flow cytometry and MTT cell proliferation assays. The WIF1, NLK, and APC promoters were hypermethylated in all eight cell lines. 5-Aza-dC displayed a growth inhibitory effect on cells . After transfection with miR-BART19-3p mimics, the expression of WIF1, and APC decreased, and the cellular proliferation rate increased. After transfection with the miR-BART19-3p inhibitor, the expression levels were higher, and the cell growth was inhibited. In the NPC and GC cell lines, the promoters of WIF1, NLK, and APC are highly methylated, and the expression of these three genes is regulated by miR-BART19-3p. The activity of the Wnt pathway in EBV-associated tumors may be enhanced by miR-BART19-3p. © 2017 Wiley Periodicals, Inc.

The Influence of Math Anxiety, Math Performance, Worry, and Test Anxiety on the Iowa Gambling Task and Balloon Analogue Risk Task.

PubMed

Buelow, Melissa T; Barnhart, Wesley R

2017-01-01

Multiple studies have shown that performance on behavioral decision-making tasks, such as the Iowa Gambling Task (IGT) and Balloon Analogue Risk Task (BART), is influenced by external factors, such as mood. However, the research regarding the influence of worry is mixed, and no research has examined the effect of math or test anxiety on these tasks. The present study investigated the effects of anxiety (including math anxiety) and math performance on the IGT and BART in a sample of 137 undergraduate students. Math performance and worry were not correlated with performance on the IGT, and no variables were correlated with BART performance. Linear regressions indicated math anxiety, physiological anxiety, social concerns/stress, and test anxiety significantly predicted disadvantageous selections on the IGT during the transition from decision making under ambiguity to decision making under risk. Implications for clinical evaluation of decision making are discussed. © The Author(s) 2015.

In-service tests of the effectiveness of vibration control measures on the BART rail transit system

NASA Astrophysics Data System (ADS)

Saurenman, Hugh; Phillips, James

2006-06-01

This paper presents results of a number of vibration measurements of the different track forms used on the current San Francisco Bay Area Rapid Transit (BART) system including floating slab, resiliently supported half-ties and high-resilience direct fixation fasteners in subway and one section of floating slab used on at-grade track. The goal was to obtain data that would improve the predictions of future vibration levels and perhaps lead to more cost effective vibration mitigation strategies for the proposed BART extension to San Jose. The tests show that the floating slabs are performing much as designed, the resiliently supported half-ties are less effective than expected, and the high resilience track fasteners are probably performing as expected although the results are clouded because of severe rail corrugation in the area where the new fasteners were installed. One unanticipated result is the apparent interaction of the floating slab resonance, the wheel rotation frequency, the bogie dynamics, and vibration propagation characteristics of the ground.

Development of a Low-Cost Stem-Loop Real-Time Quantification PCR Technique for EBV miRNA Expression Analysis.

PubMed

Bergallo, Massimiliano; Merlino, Chiara; Montin, Davide; Galliano, Ilaria; Gambarino, Stefano; Mareschi, Katia; Fagioli, Franca; Montanari, Paola; Martino, Silvana; Tovo, Pier-Angelo

2016-09-01

MicroRNAs (miRNAs) are short, single stranded, non-coding RNA molecules. They are produced by many different species and are key regulators of several physiological processes. miRNAs are also encoded by the genomes of multiple virus families, such as herpesvirus family. In particular, miRNAs from Epstein Barr virus were found at high concentrations in different associated pathologies, such as Burkitt's lymphoma, Hodgkin disease, and nasopharyngeal carcinoma. Thanks to their stability, these molecules could possibly serve as biomarkers for EBV-associated diseases. In this study, a stem-loop real-time PCR for miR-BART2-5p, miR-BART15, and miR-BART22 EBV miRNAs detection and quantification has been developed. Evaluation of these miRNAs in 31 serum samples (12 from patients affected by primary immunodeficiency, 9 from X-linked agammaglobulinemia and 10 from healthy subjects) has been carried out. The amplification performance showed a wide dynamic range (10(8)-10(2) copies/reaction) and sensibility equal to 10(2) copies/reaction for all the target tested. Serum samples analysis, on the other hand, showed a statistical significant higher level of miR-BART22 in primary immunodeficiency patients (P = 0.0001) compared to other groups and targets. The results confirmed the potential use of this assay as a tool for monitoring EBV-associated disease and for miRNAs expression profile analysis.

Quantifying arm nonuse in individuals poststroke.

PubMed

Han, Cheol E; Kim, Sujin; Chen, Shuya; Lai, Yi-Hsuan; Lee, Jeong-Yoon; Osu, Rieko; Winstein, Carolee J; Schweighofer, Nicolas

2013-06-01

Arm nonuse, defined as the difference between what the individual can do when constrained to use the paretic arm and what the individual does when given a free choice to use either arm, has not yet been quantified in individuals poststroke. (1) To quantify nonuse poststroke and (2) to develop and test a novel, simple, objective, reliable, and valid instrument, the Bilateral Arm Reaching Test (BART), to quantify arm use and nonuse poststroke. First, we quantify nonuse with the Quality of Movement (QOM) subscale of the Actual Amount of Use Test (AAUT) by subtracting the AAUT QOM score in the spontaneous use condition from the AAUT QOM score in a subsequent constrained use condition. Second, we quantify arm use and nonuse with BART by comparing reaching performance to visual targets projected over a 2D horizontal hemi-work space in a spontaneous-use condition (in which participants are free to use either arm at each trial) with reaching performance in a constrained-use condition. All participants (N = 24) with chronic stroke and with mild to moderate impairment exhibited nonuse with the AAUT QOM. Nonuse with BART had excellent test-retest reliability and good external validity. BART is the first instrument that can be used repeatedly and practically in the clinic to quantify the effects of neurorehabilitation on arm use and nonuse and in the laboratory for advancing theoretical knowledge about the recovery of arm use and the development of nonuse and "learned nonuse" after stroke.

Risk-taking propensity and sensitivity to punishment in adolescents with attention deficit and hyperactivity disorder symptoms and/or reading disability.

PubMed

Poon, Kean; Ho, Connie Suk-Han

2016-01-01

Many studies reported that adolescents with ADHD/RD more frequently engage in risk-taking behaviors. Very few have examined their risk taking patterns and the impact of their comorbidity. The present study compared the risk-taking propensity, sensitivity to punishment and delinquency outcome in Chinese adolescents with ADHD symptoms (AS) and/or RD using a simulated risk task, the Balloon Analogous Risk Task (BART). Adolescents with AS (n=37), RD (n=35), AS+RD (n=35), and control (n=36) were recruited from local secondary schools. Results showed that adolescents with ADHD, despite their great risk-taking propensity, were sensitive to immediate punishment whereas adolescents with RD were found to display normal risk-taking propensity, yet showed a tendency of being less sensitive to punishment. The comorbidity ADHD+RD group had the highest delinquency score, and exhibited greatest risk taking and least sensitivity to punishment, which provided further support that comorbid condition might have stronger impact on risk taking or even delinquency than the pure groups. The present findings provides a useful picture of the risk taking pattern associated with different groups, allowing for effective matching for future prevention and intervention program. Copyright © 2016 Elsevier Ltd. All rights reserved.

Natural Variation of Epstein-Barr Virus Genes, Proteins, and Primary MicroRNA.

PubMed

Correia, Samantha; Palser, Anne; Elgueta Karstegl, Claudio; Middeldorp, Jaap M; Ramayanti, Octavia; Cohen, Jeffrey I; Hildesheim, Allan; Fellner, Maria Dolores; Wiels, Joelle; White, Robert E; Kellam, Paul; Farrell, Paul J

2017-08-01

Viral gene sequences from an enlarged set of about 200 Epstein-Barr virus (EBV) strains, including many primary isolates, have been used to investigate variation in key viral genetic regions, particularly LMP1, Zp, gp350, EBNA1, and the BART microRNA (miRNA) cluster 2. Determination of type 1 and type 2 EBV in saliva samples from people from a wide range of geographic and ethnic backgrounds demonstrates a small percentage of healthy white Caucasian British people carrying predominantly type 2 EBV. Linkage of Zp and gp350 variants to type 2 EBV is likely to be due to their genes being adjacent to the EBNA3 locus, which is one of the major determinants of the type 1/type 2 distinction. A novel classification of EBNA1 DNA binding domains, named QCIGP, results from phylogeny analysis of their protein sequences but is not linked to the type 1/type 2 classification. The BART cluster 2 miRNA region is classified into three major variants through single-nucleotide polymorphisms (SNPs) in the primary miRNA outside the mature miRNA sequences. These SNPs can result in altered levels of expression of some miRNAs from the BART variant frequently present in Chinese and Indonesian nasopharyngeal carcinoma (NPC) samples. The EBV genetic variants identified here provide a basis for future, more directed analysis of association of specific EBV variations with EBV biology and EBV-associated diseases. IMPORTANCE Incidence of diseases associated with EBV varies greatly in different parts of the world. Thus, relationships between EBV genome sequence variation and health, disease, geography, and ethnicity of the host may be important for understanding the role of EBV in diseases and for development of an effective EBV vaccine. This paper provides the most comprehensive analysis so far of variation in specific EBV genes relevant to these diseases and proposed EBV vaccines. By focusing on variation in LMP1, Zp, gp350, EBNA1, and the BART miRNA cluster 2, new relationships with the known type 1/type 2 strains are demonstrated, and a novel classification of EBNA1 and the BART miRNAs is proposed. Copyright © 2017 Correia et al.

Modeling behavioral reactivity to losses and rewards on the Balloon Analogue Risk Task (BART): moderation by alcohol problem severity.

PubMed

Ashenhurst, James R; Bujarski, Spencer; Jentsch, J David; Ray, Lara A

2014-08-01

The relationship between risk-taking behavior and substance dependence has proven to be complex, particularly when examining across participants expressing a range of substance use problem severity. While main indices of risk-taking in the Balloon Analogue Risk Task (BART) positively associate with problematic alcohol use in adolescent populations (e.g., MacPherson, Magidson, Reynolds, Kahler, & Lejuez, 2010), several studies have observed a negative relationship when examining behavior within adult substance using populations (Ashenhurst, Jentsch, & Ray, 2011; Campbell, Samartgis, & Crowe, 2013). To examine potential mechanisms that underlie this negative relationship, we implemented multilevel regression models on trial-by-trial BART data gathered from 295 adult problem drinkers. These models accounted for participant behavior on trials following balloon bursts or cash outs as indices of loss and reward reactivity, respectively, and included control variables including age, IQ, and individual delay discounting rate. Results revealed that individual trial pumping was significantly predicted by trial number, and by whether or not the previous trial was a big burst or a big cash out (i.e., large magnitude of potential gains) in a manner consistent with a "near-miss" effect. Furthermore, severity of alcohol problems moderated the effect of a previous trial big burst, but not of a big cash out, on subsequent trial behavior such that those with greater severity demonstrated relative insensitivity to this "near-miss" effect. These results extend previous studies suggesting that alcohol abusers are less risky on the BART by specifying a mechanism underlying this pattern, namely, diminished reactivity to large magnitude losses.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gibson, Adam Paul

The authors present a measurement of the mass of the top quark. The event sample is selected from proton-antiproton collisions, at 1.96 TeV center-of-mass energy, observed with the CDF detector at Fermilab's Tevatron. They consider a 318 pb -1 dataset collected between March 2002 and August 2004. They select events that contain one energetic lepton, large missing transverse energy, exactly four energetic jets, and at least one displaced vertex b tag. The analysis uses leading-order tmore » $$\\bar{t}$$ and background matrix elements along with parameterized parton showering to construct event-by-event likelihoods as a function of top quark mass. From the 63 events observed with the 318 pb -1 dataset they extract a top quark mass of 172.0 ± 2.6(stat) ± 3.3(syst) GeV/c 2 from the joint likelihood. The mean expected statistical uncertainty is 3.2 GeV/c 2 for m $$\\bar{t}$$ = 178 GTeV/c 2 and 3.1 GeV/c 2 for m $$\\bar{t}$$ = 172.5 GeV/c 2. The systematic error is dominated by the uncertainty of the jet energy scale.« less

Profiling of EBV-Encoded microRNAs in EBV-Associated Hemophagocytic Lymphohistiocytosis.

PubMed

Zhou, Chen; Xie, Zhengde; Gao, Liwei; Liu, Chunyan; Ai, Junhong; Zhang, Li; Shen, Kunling

2015-10-01

Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening complication of EBV infection. MicroRNAs (miRNAs) were small non-coding RNA, and EBV could encode miRNAs that are involved in the progression of infection. However, the profiles of EBV-miRNAs in EBV-HLH were unknown. Here, we aimed to profile the expression of EBV-miRNAs in children with EBV-HLH by analyzing 44 known EBV-miRNAs, encoded within the BamHI fragment H rightward open reading frame 1 (BHRF1) and the BamHI-A region rightward transcript (BART), in plasma and cellular targets by real-time quantitative PCR. The study included 15 children with EBV-HLH, 15 children with infectious mononucleosis (IM), and 15 healthy controls. CD8(+) T cells were found to be the cellular target of EBV infection in EBV-HLH, while CD19(+) B cells were infected with EBV in IM. We also found the greater levels of several miRNAs encoded by BART in EBV-HLH, compared to those in IM and healthy controls, whereas the levels of BHRF1 miRNAs were lower than those in IM. The profile and pattern of EBV-miRNAs in EBV-HLH indicated that EBV could display type II latency in EBV-HLH. Importantly, the level of plasma miR-BART16-1 continued decreasing during the whole chemotherapy, suggesting that plasma miR-BART16-1 could be a potential biomarker for monitoring EBV-HLH progression. The pathogenesis of EBV-HLH might be attributed to the abundance of EBV-miRNAs in EBV-HLH. These findings help elucidate the roles of EBV miRNAs in EBV-HLH, enabling the understanding of the basis of this disease and providing clues for its treatment.

A Study of Particulate Matter (PM 2.5) Concentrations in Bay Area Rapid Transit (BART) Railway Stations

NASA Astrophysics Data System (ADS)

Daniel, M.; Grzesik, D.; Hailegebreal, A.; Hegde, S.; Johnson, M.; Lieu, E.; Zhen, K.; Stovall, J.

2015-12-01

Previous research has shown that Embarcadero's BART station has high concentrations of airborne Particulate Matter (PM 2.5). Newly developed, commercially available open-source sensors have been designed to accurately measure PM 2.5 at a cost that is a fraction of the commercially available DustTrak device used in previous work. Our team conducted multiple follow-up sampling events, measuring PM 2.5 using co-located AirBeam and DustTrak devices at BART stations. Overall, our research indicates that PM 2.5 concentrations at Embarcadero have not declined since previous sampling efforts were undertaken in 2013. Also, the low cost AirBeam sensors were found to be less effective at measuring elevated PM 2.5 concentrations such as those found in the Embarcadero BART station. However, the AirBeam devices were effective at quickly identifying areas with elevated PM 2.5. Our research also indicates a decrease in concentration of PM 2.5 as one moves west along the station platform away from the East Bay Tube that connects San Francisco to the East San Francisco Bay Area. We speculate that the East Bay Tube is a reservoir of hazardous fine-grained particulate matter, which poses a significant human health risk, particularly in emergency evacuations or for workers with chronic exposure. The research has been used to refine a conceptual site model of the source for airborne particles found at the Embarcadero Station and suggests that primary source control via high-pressure-washing of the East Bay Tube may be an economical and rapid remedy prior to improved ventilation and engineering controls.

Differential impact of serotonin transporter activity on temperament and behavior in persons with a family history of alcoholism in the Oklahoma Family Health Patterns project

PubMed Central

Lovallo, William R.; Enoch, Mary-Anne; Yechiam, Eldad; Glahn, David C.; Acheson, Ashley; Sorocco, Kristen H.; Hodgkinson, Colin A.; Kim, Bojeong; Cohoon, Andrew J.; Vincent, Andrea S.; Goldman, David

2014-01-01

Background Central serotonergic (5-HT) function is implicated in pathways to alcohol dependence, including dysphoria manifested by symptoms of anxiety and depression. However, little is known about genetic variation in central 5-HT function and its potential impact on temperament and behavior in persons with a family history of alcoholism (FH+). Methods We tested 314 healthy young adults (23.5 yr of age, 57% female; 193 FH− and 121 FH+) enrolled in the Oklahoma Family Health Patterns project, a study of alcoholism risk in relation to temperament and behavioral dyscontrol. Dysphoria was assessed using the Eysenck neuroticism and Beck depression scales, and Cloninger’s Tridimensional Personality Questionnaire. Risk taking was assessed with the Iowa Gambling Task (IGT) and Balloon Analogue Response Task (BART). All subjects were genotyped for a functional polymorphism (5-HTTLPR) in the promoter region of the serotonin transporter gene (SCL6A4). Results FH+ subjects with the gain-of-function 5-HTTLPR genotype scored higher in neuroticism, harm avoidance, and symptoms of Depression (p values ≤ .03). No effect of 5-HTTLPR genotype was seen in FH−. FH+ carriers of the gain-of-function 5-HTTLPR genotype played to minimize their frequency of losses in the IGT whereas FH− carriers played a balanced strategy (p < .003). No 5-HTTLPR effects were seen in the BART. Results were unaffected by sex, education, drug use, and antisocial characteristics. Conclusions The functional 5-HTTLPR polymorphism predicted significant variation in negative moods and poorer affect regulation in FH+ persons, with possible consequences for behavior, as seen in a simulated gambling task. This pattern may contribute to a drinking pattern that is compensatory for such affective tendencies. PMID:24796636

Differential impact of serotonin transporter activity on temperament and behavior in persons with a family history of alcoholism in the Oklahoma Family Health Patterns Project.

PubMed

Lovallo, William R; Enoch, Mary-Anne; Yechiam, Eldad; Glahn, David C; Acheson, Ashley; Sorocco, Kristen H; Hodgkinson, Colin A; Kim, Bojeong; Cohoon, Andrew J; Vincent, Andrea S; Goldman, David

2014-06-01

Central serotonergic (5-HT) function is implicated in pathways to alcohol dependence, including dysphoria manifested by symptoms of anxiety and depression. However, little is known about genetic variation in central 5-HT function and its potential impact on temperament and behavior in persons with a family history of alcoholism (FH+). We tested 314 healthy young adults (23.5 years of age, 57% female; 193 FH- and 121 FH+) enrolled in the Oklahoma Family Health Patterns project, a study of alcoholism risk in relation to temperament and behavioral dyscontrol. Dysphoria was assessed using the Eysenck neuroticism and Beck depression scales, and Cloninger's Tridimensional Personality Questionnaire. Risk taking was assessed with the Iowa Gambling Task (IGT) and Balloon Analogue Response Task (BART). All subjects were genotyped for a functional polymorphism (5-HTTLPR) in the promoter region of the serotonin transporter gene (SLC6A4). FH+ subjects with the gain-of-function 5-HTTLPR genotype scored higher in neuroticism, harm avoidance, and symptoms of depression (p-values ≤ 0.03). No effect of 5-HTTLPR genotype was seen in FH-. FH+ carriers of the gain-of-function 5-HTTLPR genotype played to minimize their frequency of losses in the IGT, whereas FH- carriers played a balanced strategy (p < 0.003). No 5-HTTLPR effects were seen in the BART. Results were unaffected by sex, education, drug use, and antisocial characteristics. The functional 5-HTTLPR polymorphism predicted significant variation in negative moods and poorer affect regulation in FH+ persons, with possible consequences for behavior, as seen in a simulated gambling task. This pattern may contribute to a drinking pattern that is compensatory for such affective tendencies. Copyright © 2014 by the Research Society on Alcoholism.

The Role of Atmospheric Organic Nitrogen in Forest Nitrogen Cycling

NASA Astrophysics Data System (ADS)

Lockwood, A.; Shepson, P.; Rhodes, D.

2003-12-01

Changes in the global climate and atmosphere cause significant effects to the biosphere. Forests respond to these global changes in various ways which all can affect their ability to store carbon, which in turn impacts climate change. Many temperate latitude forests are nitrogen-limited. A current working hypothesis is that atmospheric nitrogen compounds that are deposited to the canopy may be directly utilized by the plant as a nitrogen source. A significant fraction of atmospheric reactive nitrogen that can be deposited is organic. Organic nitrogen deposition is not well characterized nor have the ecological consequences been assessed. Our hypothesis is that organic nitrogen deposition to the canopy is significant, and that that nitrogen is utilized by trees. Fumigation experiments were conducted with 14N and 15N-labeled organic nitrates (focusing on 1-nitrooxy-3-methyl butane as a surrogate for isoprene nitrates) to determine if and how that nitrogen gets incorporated into the leaves by detecting the 15N-labeled leaf amino acids. This research builds on work completed during past summer intensives as part of the Program for Research on Oxidants: PHotochemistry, Emissions, and Transport (PROPHET), and begins the next stage of research as part of the Biosphere Atmosphere Research & Training program (BART) at the University of Michigan Biological Station (UMBS). The overall goal of the new effort, the Biosphere Exchange of Atmospheric Carbon and Odd Nitrogen (BEACON) program, is to evaluate the interactive roles of the atmosphere and forest in the coupling of the carbon and nitrogen cycles.

Comparison of Nine Statistical Model Based Warfarin Pharmacogenetic Dosing Algorithms Using the Racially Diverse International Warfarin Pharmacogenetic Consortium Cohort Database

PubMed Central

Liu, Rong; Li, Xi; Zhang, Wei; Zhou, Hong-Hao

2015-01-01

Objective Multiple linear regression (MLR) and machine learning techniques in pharmacogenetic algorithm-based warfarin dosing have been reported. However, performances of these algorithms in racially diverse group have never been objectively evaluated and compared. In this literature-based study, we compared the performances of eight machine learning techniques with those of MLR in a large, racially-diverse cohort. Methods MLR, artificial neural network (ANN), regression tree (RT), multivariate adaptive regression splines (MARS), boosted regression tree (BRT), support vector regression (SVR), random forest regression (RFR), lasso regression (LAR) and Bayesian additive regression trees (BART) were applied in warfarin dose algorithms in a cohort from the International Warfarin Pharmacogenetics Consortium database. Covariates obtained by stepwise regression from 80% of randomly selected patients were used to develop algorithms. To compare the performances of these algorithms, the mean percentage of patients whose predicted dose fell within 20% of the actual dose (mean percentage within 20%) and the mean absolute error (MAE) were calculated in the remaining 20% of patients. The performances of these techniques in different races, as well as the dose ranges of therapeutic warfarin were compared. Robust results were obtained after 100 rounds of resampling. Results BART, MARS and SVR were statistically indistinguishable and significantly out performed all the other approaches in the whole cohort (MAE: 8.84–8.96 mg/week, mean percentage within 20%: 45.88%–46.35%). In the White population, MARS and BART showed higher mean percentage within 20% and lower mean MAE than those of MLR (all p values < 0.05). In the Asian population, SVR, BART, MARS and LAR performed the same as MLR. MLR and LAR optimally performed among the Black population. When patients were grouped in terms of warfarin dose range, all machine learning techniques except ANN and LAR showed significantly higher mean percentage within 20%, and lower MAE (all p values < 0.05) than MLR in the low- and high- dose ranges. Conclusion Overall, machine learning-based techniques, BART, MARS and SVR performed superior than MLR in warfarin pharmacogenetic dosing. Differences of algorithms’ performances exist among the races. Moreover, machine learning-based algorithms tended to perform better in the low- and high- dose ranges than MLR. PMID:26305568

Measurement of the cross section ratio $$\\sigma_\\mathrm{t \\bar{t} b \\bar{b}} / \\sigma_\\mathrm{t \\bar{t} jj }$$ in pp collisions at $$\\sqrt{s}$$ = 8 TeV

DOE PAGES

Khachatryan, Vardan

2015-04-30

In this study, the first measurement of the cross section ratio σ ttbb¯/σ ttjj is presented using a data sample corresponding to an integrated luminosity of 19.6 fb –1 collected in pp collisions at √s = 8 with the CMS detector at the LHC. Events with two leptons (e or μ ) and four reconstructed jets, including two identified as b quark jets, in the final state are selected. The ratio is determined for a minimum jet transverse momentum p T of both 20 and 40 GeV/c.

Measurement of the t $$\\bar{t}$$ Cross-Section Using the Dimuon Channel in p$$\\bar{p}$$ Collisions at √s = 1.96-TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

McCroskey, Robert Crampton

2004-01-01

The author has measured the tmore » $$\\bar{t}$$ production cross section at √s = 1.96 TeV using data collected by the D0 experiment at Fermilab. The integrated luminosity of the data set is 140 pb -1 and a total of four candidate events are seen, with an expected background of 2.61 events. The measured cross section of σ t$$\\bar{t}$$ = 11.1$$+22.1\\atop{-9.3}$$(stat.)$$+4.3\\atop{-4.5}$$(sys.) pb is in agreement with a NNLO calculation of 6.77 pb.« less

Effects of Age and Initial Risk Perception on Balloon Analog Risk Task: The Mediating Role of Processing Speed and Need for Cognitive Closure

PubMed Central

Koscielniak, Maciej; Rydzewska, Klara; Sedek, Grzegorz

2016-01-01

According to the dual-process theoretical perspective adopted in the presented research, the efficiency of deliberative processes in decision making declines with age, but experiential processes are relatively well-preserved. The age-related differences in deliberative and experiential processes in risky decision-making were examined in this research by applying the Balloon Analog Risk Task (BART). We analyzed the influence of age on risk acceptance and decision-making performance in two age groups of female participants (younger adults, n = 81; older adults, n = 76), with additional experimental manipulation of initial risk perception. We predicted and confirmed that aging significantly worsens performance on the behavioral BART measures due to age-related decline in deliberative processes. Older participants were found to exhibit significantly higher risk aversion and lower BART performance, and the effect of age was mediated by cognitive (processing speed) and motivational (need for cognitive closure) mechanisms. Moreover, older adults adapt to the initial failure (vs. success) similarly, as younger adults due to preserved efficiency of experiential processes. These results suggest future directions for minimizing negative effects of aging in risky decision-making and indicate compensatory processes, which are preserved during aging. PMID:27199877

Escalating risk and the moderating effect of resistance to peer influence on the P200 and feedback-related negativity.

PubMed

Kiat, John; Straley, Elizabeth; Cheadle, Jacob E

2016-03-01

Young people frequently socialize together in contexts that encourage risky decision making, pointing to a need for research into how susceptibility to peer influence is related to individual differences in the neural processing of decisions during sequentially escalating risk. We applied a novel analytic approach to analyze EEG activity from college-going students while they completed the Balloon Analogue Risk Task (BART), a well-established risk-taking propensity assessment. By modeling outcome-processing-related changes in the P200 and feedback-related negativity (FRN) sequentially within each BART trial as a function of pump order as an index of increasing risk, our results suggest that analyzing the BART in a progressive fashion may provide valuable new insights into the temporal neurophysiological dynamics of risk taking. Our results showed that a P200, localized to the left caudate nucleus, and an FRN, localized to the left dACC, were positively correlated with the level of risk taking and reward. Furthermore, consistent with our hypotheses, the rate of change in the FRN was higher among college students with greater self-reported resistance to peer influence. © The Author (2015). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

The role of Epstein–Barr virus in epithelial malignancies

PubMed Central

Tsao, Sai-Wah; Tsang, Chi Man; To, Ka-Fai; Lo, Kwok-Wai

2015-01-01

The close association of Epstein–Barr virus (EBV) infection with non-keratinizing nasopharyngeal carcinomas and a subset of gastric carcinomas suggests that EBV infection is a crucial event in these cancers. The difficulties encountered in infecting and transforming primary epithelial cells in experimental systems suggest that the role of EBV in epithelial malignancies is complex and multifactorial in nature. Genetic alterations in the premalignant epithelium may support the establishment of latent EBV infection, which is believed to be an initiation event. Oncogenic properties have been reported in multiple EBV latent genes. The BamH1 A rightwards transcripts (BARTs) and the BART-encoded microRNAs (miR-BARTs) are highly expressed in EBV-associated epithelial malignancies and may induce malignant transformation. However, enhanced proliferation may not be the crucial function of EBV infection in epithelial malignancies, at least in the early stages of cancer development. EBV-encoded gene products may confer anti-apoptotic properties and promote the survival of infected premalignant epithelial cells harbouring genetic alterations. Multiple EBV-encoded microRNAs have been reported to have immune evasion functions. Genetic alterations in host cells, as well as inflammatory stroma, could modulate the expression of EBV genes and alter the growth properties of infected premalignant epithelial cells, encouraging their selection during carcinogenesis. PMID:25251730

Test-retest assessment of functional near-infrared spectroscopy to measure risk decision making in young adults

NASA Astrophysics Data System (ADS)

Li, Lin; Lin, Zijing; Cazzell, Mary; Liu, Hanli

2013-03-01

Investigation of the reliability and reproducibility of the hemodynamic response is important for interpretation and understanding of the results of functional near-infrared spectroscopy (fNIRS). It measures optical signals absorbed by the brain tissue and reflects the neuronal activities indirectly. Here we described an fNIRS study measured in the prefrontal region (Brodman area 9, 10, part of 46)to examine the risk decision-making behavior in nine young adults. The Balloon Analog Risk Task (BART) is widely used to test the level of risk taking ability in the field of psychology. BART was a protocol utilized in this study to evoke a risk-taking environment with a gambling-like balloon game in each subject. Specifically, we recorded the brain oxygenated-hemoglobin (HbO) and deoxygenated-hemoglobin (HHb) changes during the two repeated measurements within a time interval of 3 weeks. The results demonstrate that the changes in HbO2 amplitudes have high reliability at the group level, and that the spatial patterns of the tomographic images have high reproducibility in size and a moderate degree of overlap. Overall, this study confirms that the hemodynamic response to risk decision-making (i.e., BART) seen by fNIRS is highly reliable and reproducible.

The relationship between insulin resistance and endothelial dysfunction in obese adolescents.

PubMed

Brar, Preneet Cheema; Patel, Payal; Katz, Stuart

2017-05-24

Insulin resistance and endothelial dysfunction share a reciprocal relationship that links the metabolic and cardiovascular sequelae of obesity. We characterized the brachial artery reactivity testing (BART) and carotid artery-intima media thickness (CIMT) in adolescents categorized as obese insulin resistant (OIR) and obese not insulin resistant (ONIR). Lipoprotein particle (p) analysis and inflammatory cytokines in OIR and ONIR groups were also analyzed. Obese adolescents (n=40; mean body mass index [BMI] 35.6) were categorized as ONIR and OIR based on their homeostatic model assessment of insulin resistance (HOMA-IR) calculation (≤or> than 3.4). Ultrasound measured conduit arterial function BART, microvascular function (post-ischemic hyperemia) and conduit artery structure CIMT. BART did not differ according to IR status (mean±SD: 7.0±4.3% vs. 5.9±3.4% in ONIR and OIR, respectively, p=0.3, but post-ischemic hyperemia was significantly greater in the ONIR group (4.5±2.2 vs. 3.5±3, p=0.04). Atherogenic lipoprotein particles; large VLDL particles and small LDL particles were higher in the OIR compared to ONIR group. OIR adolescents demonstrate an inflamed atherogenic milieu compared to the ONIR adolescents. Microvascular function, but not conduit vessel structure or function, was impaired in association with IR.

In-service tests of the effectiveness of vibration control measures on the BART rail transit system

NASA Astrophysics Data System (ADS)

Saurenman, Hugh

2005-09-01

Controlling vibration from new rail transit systems can be quite expensive when the alignment passes through residential areas. However, there is relatively little documented information on how effective different vibration mitigation approaches perform under in-service conditions. This paper presents results of a number of vibration measurements of the different track forms used on the current San Francisco Bay Area Rapid Transit (BART) system including floating slab, resiliently supported half ties, and high-resilience direct fixation fasteners in subways and one section of floating slab used on at-grade tracks. The goal was to obtain data that would improve the predictions of future vibration levels and perhaps lead to more cost effective vibration mitigation strategies for the proposed BART extension to San Jose. The tests show that the floating slabs are performing much as designed, the resiliently supported half ties are less effective than expected, and the high resilience track fasteners are probably performing as expected, although the results are clouded because of severe rail corrugation in the area where the new fasteners were installed. Some unanticipated results are the apparent interaction of the floating slab resonance, the wheel rotation frequency, the bogey dynamics, and vibration propagation characteristics of the ground.

Estimating population trends with a linear model: Technical comments

USGS Publications Warehouse

Sauer, John R.; Link, William A.; Royle, J. Andrew

2004-01-01

Controversy has sometimes arisen over whether there is a need to accommodate the limitations of survey design in estimating population change from the count data collected in bird surveys. Analyses of surveys such as the North American Breeding Bird Survey (BBS) can be quite complex; it is natural to ask if the complexity is necessary, or whether the statisticians have run amok. Bart et al. (2003) propose a very simple analysis involving nothing more complicated than simple linear regression, and contrast their approach with model-based procedures. We review the assumptions implicit to their proposed method, and document that these assumptions are unlikely to be valid for surveys such as the BBS. One fundamental limitation of a purely design-based approach is the absence of controls for factors that influence detection of birds at survey sites. We show that failure to model observer effects in survey data leads to substantial bias in estimation of population trends from BBS data for the 20 species that Bart et al. (2003) used as the basis of their simulations. Finally, we note that the simulations presented in Bart et al. (2003) do not provide a useful evaluation of their proposed method, nor do they provide a valid comparison to the estimating- equations alternative they consider.

A Study of Particulate Matter (PM2.5) Concentration Variance by Distance from Train Platform at a Major Bay Area Rapid Transit (BART) Railway Station

NASA Astrophysics Data System (ADS)

Solis, M.; Nguyen, H.; Adeyan, A.; Adeyan, E.; Taylor, S.; Hardaway, K.; Peterson, E.; Ortega, J.; Marshall, R.

2017-12-01

Over the past five years, the East Bay Academy for Young Scientists (EBAYS) has been investigating air quality at Bay Area Rapid Transit (BART) train stations. In particular, prior EBAYS research has revealed extremely high levels of particulate matter (PM 2.5) at the multi-leveled Embarcadero Station, which is underground and is one of the most frequently visited stations in the entire BART system. During the summer of 2017 data was collected to determine whether or not air quality differed on the three levels of this station. In conducting this study the research team was separated into pairs, each pair in possession of a Dustrak II or AirBeam PM analyzer and each pair assigned to a particular level. Within each measurement trial data was collected for 15 minutes. Measurements were also made on the eastern and western ends of the platforms to detect possible variations in PM concentration. Preliminary results obtained thus far indicate that dangerously high levels of PM 2.5 concentration occur on all three levels of the station. This is especially problematic because it suggests that individuals who spend extensive amounts of time at this station (e.g., station agents and other workers) are exposed to extremely high PM 2.5 concentration levels and as a result are working under conditions that are quite hazardous to their health. Based on observations made during testing, increased levels of PM 2.5 tend to correlate with the departure or arrival of BART trains that results in particulate matter being scattered about the train platform and other levels. Further studies should be conducted to verify this observation and to contribute to better understanding the sources and behavior of PM 2.5 at each level of the station.

Early-onset Conduct Problems: Predictions from daring temperament and risk taking behavior.

PubMed

Bai, Sunhye; Lee, Steve S

2017-12-01

Given its considerable public health significance, identifying predictors of early expressions of conduct problems is a priority. We examined the predictive validity of daring, a key dimension of temperament, and the Balloon Analog Risk Task (BART), a laboratory-based measure of risk taking behavior, with respect to two-year change in parent, teacher-, and youth self-reported oppositional defiant disorder (ODD), conduct disorder (CD), and antisocial behavior. At baseline, 150 ethnically diverse 6- to 10-year old (M=7.8, SD=1.1; 69.3% male) youth with ( n =82) and without ( n =68) DSM-IV ADHD completed the BART whereas parents rated youth temperament (i.e., daring); parents and teachers also independently rated youth ODD and CD symptoms. Approximately 2 years later, multi-informant ratings of youth ODD, CD, and antisocial behavior were gathered from rating scales and interviews. Whereas risk taking on the BART was unrelated to conduct problems, individual differences in daring prospectively predicted multi-informant rated conduct problems, independent of baseline risk taking, conduct problems, and ADHD diagnostic status. Early differences in the propensity to show positive socio-emotional responses to risky or novel experiences uniquely predicted escalating conduct problems in childhood, even with control of other potent clinical correlates. We consider the role of temperament in the origins and development of significant conduct problems from childhood to adolescence, including possible explanatory mechanisms underlying these predictions.

A study of riders' noise exposure on Bay Area Rapid Transit trains.

PubMed

Dinno, Alexis; Powell, Cynthia; King, Margaret Mary

2011-02-01

Excessive noise exposure may present a hazard to hearing, cardiovascular, and psychosomatic health. Mass transit systems, such as the Bay Area Rapid Transit (BART) system, are potential sources of excessive noise. The purpose of this study was to characterize transit noise and riders' exposure to noise on the BART system using three dosimetry metrics. We made 268 dosimetry measurements on a convenience sample of 51 line segments. Dosimetry measures were modeled using linear and nonlinear multiple regression as functions of average velocity, tunnel enclosure, flooring, and wet weather conditions and presented visually on a map of the BART system. This study provides evidence of levels of hazardous levels of noise exposure in all three dosimetry metrics. L(eq) and L(max) measures indicate exposures well above ranges associated with increased cardiovascular and psychosomatic health risks in the published literature. L(peak) indicate acute exposures hazardous to adult hearing on about 1% of line segment rides and acute exposures hazardous to child hearing on about 2% of such rides. The noise to which passengers are exposed may be due to train-specific conditions (velocity and flooring), but also to rail conditions (velocity and tunnels). These findings may point at possible remediation (revised speed limits on longer segments and those segments enclosed by tunnels). The findings also suggest that specific rail segments could be improved for noise.

Prefrontal transcranial direct current stimulation alters activation and connectivity in cortical and subcortical reward systems: a tDCS-fMRI study.

PubMed

Weber, Matthew J; Messing, Samuel B; Rao, Hengyi; Detre, John A; Thompson-Schill, Sharon L

2014-08-01

Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique used both experimentally and therapeutically to modulate regional brain function. However, few studies have directly measured the aftereffects of tDCS on brain activity or examined changes in task-related brain activity consequent to prefrontal tDCS. To investigate the neural effects of tDCS, we collected fMRI data from 22 human subjects, both at rest and while performing the Balloon Analog Risk Task (BART), before and after true or sham transcranial direct current stimulation. TDCS decreased resting blood perfusion in orbitofrontal cortex and the right caudate and increased task-related activity in the right dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) in response to losses but not wins or increasing risk. Network analysis showed that whole-brain connectivity of the right ACC correlated positively with the number of pumps subjects were willing to make on the BART, and that tDCS reduced connectivity between the right ACC and the rest of the brain. Whole-brain connectivity of the right DLPFC also correlated negatively with pumps on the BART, as prior literature would suggest. Our results suggest that tDCS can alter activation and connectivity in regions distal to the electrodes. Copyright © 2014 Wiley Periodicals, Inc.

HAT-P-16b: A Bayesian Atmospheric Retrieval

NASA Astrophysics Data System (ADS)

McIntyre, Kathleen; Harrington, Joseph; Blecic, Jasmina; Cubillos, Patricio; Challener, Ryan; Bakos, Gaspar

2017-10-01

HAT-P-16b is a hot (equilibrium temperature 1626 ± 40 K, assuming zero Bond albedo and efficient energy redistribution), 4.19 ± 0.09 Jupiter-mass exoplanet orbiting an F8 star every 2.775960 ± 0.000003 days (Buchhave et al 2010). We observed two secondary eclipses of HAT-P-16b using the 3.6 μm and 4.5 μm channels of the Spitzer Space Telescope's Infrared Array Camera (program ID 60003). We applied our Photometry for Orbits, Eclipses, and Transits (POET) code to produce normalized eclipse light curves, and our Bayesian Atmospheric Radiative Transfer (BART) code to constrain the temperature-pressure profiles and atmospheric molecular abundances of the planet. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

Michael Griffin House Science Committee Hearing

NASA Image and Video Library

2005-06-27

Rep. Bart Gordon, D-TN., questions NASA Administrator Michael Griffin during a House Science Committee hearing, Tuesday, June 28, 2005, Rayburn House Office building, Washington. Photo Credit: (NASA/Bill Ingalls)

Neural responses to negative outcomes predict success in community-based substance use treatment

PubMed Central

Forster, Sarah E.; Finn, Peter R.; Brown, Joshua W.

2017-01-01

Background and aims Activation in some specific brain regions has demonstrated promise as prognostic indicators in substance dependent individuals (SDIs) but this issue has not yet been explored in SDIs attending typical of community-based treatment. We used a data-driven, exploratory approach to identify brain-based predictors of treatment outcome in a representative community sample of SDIs. The predictive utility of brain-based measures was evaluated against clinical indicators, cognitive-behavioral performance, and self-report assessments. Design Prospective clinical outcome design, evaluating baseline functional magnetic resonance imaging data from the Balloon Analogue Risk Task (BART) as a predictor of 3-month substance use treatment outcomes. Setting Community-based substance use programs in Bloomington, Indiana, USA. Participants Twenty-three SDIs (17 male, ages 18–43) in an intensive outpatient or residential treatment program; abstinent 1–4 weeks at baseline. Measurements Event-related brain response, BART performance, and self-report scores at treatment onset, substance use outcome measure (based on days of use) Findings Using voxel-level predictive modeling and leave-one-out cross-validation, an elevated response to unexpected negative feedback in bilateral amygdala and anterior hippocampus (Amyg/aHipp) at baseline successfully predicted greater substance use over the 3-month study interval (p ≤ 0.006, cluster-corrected). This effect was robust to inclusion of significant non-brain-based covariates. A larger response to negative feedback in bilateral Amyg/aHipp was also associated with faster reward-seeking responses after negative feedback (r(23) = −0.544, p = 0.007; r(23) = −0.588, p = 0.003). A model including Amyg/aHipp activation, faster reward-seeking after negative feedback, and significant self-report scores accounted for 45% of the variance in substance use outcomes in our sample. Conclusions An elevated response to unexpected negative feedback in bilateral amygdala and anterior hippocampus (Amyg/aHipp) appears to predict relapse to substance use in people attending community-based treatment. PMID:28029198

BMP4 Signaling Is Able to Induce an Epithelial-Mesenchymal Transition-Like Phenotype in Barrett’s Esophagus and Esophageal Adenocarcinoma through Induction of SNAIL2

PubMed Central

Kestens, Christine; Siersema, Peter D.; Offerhaus, G. Johan A.; van Baal, Jantine W. P. M.

2016-01-01

Background Bone morphogenetic protein 4 (BMP4) signaling is involved in the development of Barrett’s esophagus (BE), a precursor of esophageal adenocarcinoma (EAC). In various cancers, BMP4 has been found to induce epithelial-mesenchymal transition (EMT) but its function in the development of EAC is currently unclear. Aim To investigate the expression of BMP4 and several members of the BMP4 pathway in EAC. Additionally, to determine the effect of BMP4 signaling in a human Barrett’s esophagus (BAR-T) and adenocarcinoma (OE33) cell line. Methods Expression of BMP4, its downstream target ID2 and members of the BMP4 pathway were determined by Q-RT-PCR, immunohistochemistry and Western blot analysis using biopsy samples from EAC patients. BAR-T and OE33 cells were incubated with BMP4 or the BMP4 antagonist, Noggin, and cell viability and migration assays were performed. In addition, expression of factors associated with EMT (SNAIL2, CDH1, CDH2 and Vimentin) was evaluated by Q-RT-PCR and Western blot analysis. Results Compared to squamous epithelium (SQ), BMP4 expression was significantly upregulated in EAC and BE. In addition, the expression of ID2 was significantly upregulated in EAC and BE compared to SQ. Western blot analysis confirmed our results, showing an upregulated expression of BMP4 and ID2 in both BE and EAC. In addition, more phosphorylation of SMAD1/5/8 was observed. BMP4 incubation inhibited cell viability, but induced cell migration in both BAR-T and OE33 cells. Upon BMP4 incubation, SNAIL2 expression was significantly upregulated in BAR-T and OE33 cells while CDH1 expression was significantly downregulated. These results were confirmed by Western blot analysis. Conclusion Our results indicate active BMP4 signaling in BE and EAC and suggest that this results in an invasive phenotype by inducing an EMT-like response through upregulation of SNAIL2 and subsequent downregulation of CDH1. PMID:27191723

77 FR 20333 - Approval, Disapproval and Promulgation of Implementation Plans; Nebraska; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-04

...; Federal Implementation Plan for Best Available Retrofit Technology Determination; Extension of Public... Best Available Retrofit Technology (BART) requirements for sulfur dioxide (SO 2 ) at one source in...

Advanced data acquisition and display techniques for laser velocimetry

NASA Technical Reports Server (NTRS)

Kjelgaard, Scott O.; Weston, Robert P.

1991-01-01

The Basic Aerodynamics Research Tunnel (BART) has been equipped with state-of-the-art instrumentation for acquiring the data needed for code validation. This paper describes the three-component LDV and the workstation-based data-acquisition system (DAS) which has been developed for the BART. The DAS allows the use of automation and the quick integration of advanced instrumentation, while minimizing the software development time required between investigations. The paper also includes a description of a graphics software library developed to support the windowing environment of the DAS. The real-time displays generated using the graphics library help the researcher ensure the test is proceeding properly. The graphics library also supports the requirements of posttest data analysis. The use of the DAS and graphics libraries is illustrated by presenting examples of the real-time and postprocessing display graphics for LDV investigations.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aaboud, M.; Aad, G.; Abbott, B.

A measurement of the inclusive p p → tmore » $$\\bar{t}$$ + X production cross section in the τ + jets final state using only the hadronic decays of the τ lepton is presented. The measurement is performed using 20.2 fb -1 of proton-proton collision data recorded at a center-of-mass energy of √ s = 8 TeV with the ATLAS detector at the Large Hadron Collider. The cross section is measured via a counting experiment by imposing a set of selection criteria on the identification and kinematic variables of the reconstructed particles and jets, and on event kinematic variables and characteristics. The production cross section is measured to be σ t $$\\bar{t}$$ = 239 ± 29 pb , which is in agreement with the measurements in other final states and the theoretical predictions at this center-of-mass energy.« less

Making assessments while taking repeated risks: a pattern of multiple response pathways.

PubMed

Pleskac, Timothy J; Wershbale, Avishai

2014-02-01

Beyond simply a decision process, repeated risky decisions also require a number of cognitive processes including learning, search and exploration, and attention. In this article, we examine how multiple response pathways develop over repeated risky decisions. Using the Balloon Analogue Risk Task (BART) as a case study, we show that 2 different response pathways emerge over the course of the task. The assessment pathway is a slower, more controlled pathway where participants deliberate over taking a risk. The 2nd pathway is a faster, more automatic process where no deliberation occurs. Results imply the slower assessment pathway is taken as choice conflict increases and that the faster automatic response is a learned response. Based on these results, we modify an existing formal cognitive model of decision making during the BART to account for these dual response pathways. The slower more deliberative response process is modeled with a sequential sampling process where evidence is accumulated to a threshold, while the other response is given automatically. We show that adolescents with conduct disorder and substance use disorder symptoms not only evaluate risks differently during the BART but also differ in the rate at which they develop the more automatic response. More broadly, our results suggest cognitive models of judgment decision making need to transition from treating observed decisions as the result of a single response pathway to the result of multiple response pathways that change and develop over time.

Genetics Home Reference: Bart-Pumphrey syndrome

MedlinePlus

... 26 in cells, and may interfere with the function of other connexin proteins. This disruption could affect skin growth and also impair hearing by disturbing the conversion of sound waves to nerve impulses. Learn more about the gene ...

The contribution of apathy and increased learning trials to risky decision-making in Parkinson's disease.

PubMed

Buelow, Melissa T; Frakey, Laura L; Grace, Janet; Friedman, Joseph H

2014-02-01

Impairments in executive functioning are commonly found in Parkinson's disease (PD); however, the research into risky decision making has been mixed. The present study sought to investigate three potential hypotheses: difficulty learning the task probabilities, levodopa equivalent dose (LED), and the presence of apathy. Twenty-four individuals with idiopathic PD and 13 healthy controls completed the Frontal Systems Behavior Scale to assess current apathy, the Iowa Gambling Task, and the Balloon Analog Risk Task (BART). Results indicated that individuals with PD selected more from Deck B, a disadvantageous deck. However, with an additional set of trials, participants with PD and apathy selected more from the most risky deck (Deck A). Apathy was not related to the BART, and LED was not related to either task. Results indicate that apathy is associated with decision-making in PD, and providing additional learning trials can improve decision-making in PD without apathy.

An evaluation of the impact of digital imaging on radiographic practice and patient doses

NASA Astrophysics Data System (ADS)

Horrocks, J.; Violaki, K.

2015-09-01

Direct digital imaging technology was implemented in all areas in general and mobile radiology at Barts and the Royal London Hospitals in 2012. Evidence from recent radiation incident investigations indicates optimum exposure factors are not consistently selected, with the greater dynamic range of the digital detectors allowing sub-optimal practice. To investigate further patient dose data were extracted from the Radiology Information System for adult chest X-ray examinations in 2014, covering over 50,000 studies in the Trust. Chest X-ray examinations were selected as they are low dose but frequent examinations. The patient dose data were evaluated taking into account X-ray system type and detector performance measurements, and individual cases studies were used to highlight where practice can be improved.

Bupropion improves attention but does not affect impulsive behavior in healthy young adults.

PubMed

Acheson, Ashley; de Wit, Harriet

2008-04-01

Bupropion is an effective abstinence aid for cessation of smoking and possibly other drug use as well. There is evidence that bupropion improves attention and impulse control in certain patient populations, and improvements in these processes could mediate its efficacy as an abstinence aid. In the present study, we tested the effects of acute bupropion on measures of attention and impulsivity in healthy adults with d-amphetamine included as a positive control. Twenty-two nonsmokers (11 women) and 11 smokers (4 women) completed four 4-hr sessions where they received placebo, bupropion (150 or 300 mg), or d-amphetamine (20 mg) in capsules. Ninety minutes after capsule administration, participants were tested on attention with a simple reaction time task (SRT) and on impulsivity with the stop task, a delay and probability discounting task (DPD), and the balloon analogue risk task (BART). Participants also completed mood questionnaires during sessions. Bupropion (150 mg) decreased lapses in attention on the SRT, but did not affect performance on the stop task, DPD, or BART. Amphetamine decreased lapses in attention and speeded sensory motor processing time on the SRT but did not significantly affect responding on the stop task or DPD. On the BART, d-amphetamine tended to decrease risk taking in men but increased risk taking in women. Bupropion (300 mg) and d-amphetamine increased ratings of arousal. These results suggest that bupropion improves attention without affecting impulsive behavior in healthy adults. Improvements in attention may contribute to the effectiveness of bupropion as a pharmacotherapy for smoking.

Bupropion improves attention but does not affect impulsive behavior in healthy young adults

PubMed Central

Acheson, Ashley; de Wit, Harriet

2014-01-01

Bupropion is an effective abstinence aid for cessation of smoking and possibly other drug use as well. There is evidence that bupropion improves attention and impulse control in certain patient populations, and improvements in these processes could mediate its efficacy as an abstinence aid. In the present study, we tested the effects of acute bupropion on measures of attention and impulsivity in healthy adults with d-amphetamine included as a positive control. Twenty-two nonsmokers (11 women) and 11 smokers (4 women) completed four 4-h sessions where they received placebo, bupropion (150 or 300 mg) or d-amphetamine (20 mg) in capsules. Ninety minutes after capsule administration, participants were tested on attention with a Simple Reaction Time Task (SRT) and on impulsivity with the Stop Task, a Delay and Probability Discounting Task (DPD), and the Balloon Analogue Risk Task (BART). Participants also completed mood questionnaires during sessions. Bupropion (150 mg) decreased lapses in attention on the SRT, but did not affect performance on the Stop Task, DPD or BART. d-Amphetamine decreased lapses in attention and speeded sensory motor processing time on the SRT but did not significantly affect responding on the Stop Task or DPD. On the BART, d-amphetamine tended to decrease risk taking in men but increased risk taking in women. Bupropion (300 mg) and d-amphetamine increased ratings of arousal. These results suggest that bupropion improves attention without affecting impulsive behavior in healthy adults. Improvements in attention may contribute to the effectiveness of bupropion as a pharmacotherapy for smoking. PMID:18489015

Bayesian analogy with relational transformations.

PubMed

Lu, Hongjing; Chen, Dawn; Holyoak, Keith J

2012-07-01

How can humans acquire relational representations that enable analogical inference and other forms of high-level reasoning? Using comparative relations as a model domain, we explore the possibility that bottom-up learning mechanisms applied to objects coded as feature vectors can yield representations of relations sufficient to solve analogy problems. We introduce Bayesian analogy with relational transformations (BART) and apply the model to the task of learning first-order comparative relations (e.g., larger, smaller, fiercer, meeker) from a set of animal pairs. Inputs are coded by vectors of continuous-valued features, based either on human magnitude ratings, normed feature ratings (De Deyne et al., 2008), or outputs of the topics model (Griffiths, Steyvers, & Tenenbaum, 2007). Bootstrapping from empirical priors, the model is able to induce first-order relations represented as probabilistic weight distributions, even when given positive examples only. These learned representations allow classification of novel instantiations of the relations and yield a symbolic distance effect of the sort obtained with both humans and other primates. BART then transforms its learned weight distributions by importance-guided mapping, thereby placing distinct dimensions into correspondence. These transformed representations allow BART to reliably solve 4-term analogies (e.g., larger:smaller::fiercer:meeker), a type of reasoning that is arguably specific to humans. Our results provide a proof-of-concept that structured analogies can be solved with representations induced from unstructured feature vectors by mechanisms that operate in a largely bottom-up fashion. We discuss potential implications for algorithmic and neural models of relational thinking, as well as for the evolution of abstract thought. Copyright 2012 APA, all rights reserved.

76 FR 52387 - Approval and Promulgation of Implementation Plans; New Mexico; Federal Implementation Plan for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

...EPA is disapproving a portion of the State Implementation Plan (SIP) revision received from the State of New Mexico on September 17, 2007, for the purpose of addressing the ``good neighbor'' requirements of section 110(a)(2)(D)(i) of the Clean Air Act (CAA or Act) for the 1997 8-hour ozone National Ambient Air Quality Standards (NAAQS or standards) and the 1997 fine particulate matter (PM2.5) NAAQS. In this action, EPA is disapproving the New Mexico Interstate Transport SIP provisions that address the requirement of section 110(a)(2)(D)(i)(II) that emissions from New Mexico sources do not interfere with measures required in the SIP of any other state under part C of the CAA to protect visibility. We have found that New Mexico sources, except the San Juan Generating Station, are sufficiently controlled to eliminate interference with the visibility programs of other states. EPA is promulgating a Federal Implementation Plan (FIP) to address this deficiency by implementing nitrogen oxides (NOX) and sulfur dioxide (SO2) emission limits necessary at the San Juan Generating Station (SJGS), to prevent such interference. EPA found in January 2009 that New Mexico had failed to submit a SIP addressing certain regional haze (RH) requirements, including the requirement for best available retrofit technology (BART). The Clean Air Act required EPA to promulgate a FIP to address RH requirements by January 2011. This FIP addresses the RH BART requirement for NOX for SJGS. In addition, EPA is implementing sulfuric acid (H2SO4) hourly emission limits at the SJGS, to minimize the contribution of this compound to visibility impairment. This action is being taken under section 110 and part C of the CAA.

Constraining the atmosphere of exoplanet WASP-34b

NASA Astrophysics Data System (ADS)

Challener, Ryan; Harrington, Joseph; Cubillos, Patricio; Garland, Justin; Foster, Andrew S. D.; Blecic, Jasmina; Foster, Austin James; Smalley, Barry

2016-01-01

WASP-34b is a short-period exoplanet with a mass of 0.59 +/- 0.01 Jupiter masses orbiting a G5 star with a period of 4.3177 days and an eccentricity of 0.038 +/- 0.012 (Smalley, 2010). We observed WASP-34b using the 3.6 and 4.5 micron channels of the Infrared Array Camera aboard the Spitzer Space Telescope in 2010 (Program 60003). We applied our Photometry for Orbits, Eclipses, and Transits (POET) code to present eclipse-depth measurements, estimates of infrared brightness temperatures, and a refined orbit. With our Bayesian Atmospheric Radiative Transfer (BART) code, we characterized the atmosphere's temperature and pressure profile, and molecular abundances. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G. J. Blecic holds a NASA Earth and Space Science Fellowship.

Secondary eclipse observations and the atmosphere of exoplanet WASP-34b

NASA Astrophysics Data System (ADS)

Challener, Ryan C.; Harrington, Joseph; Cubillos, Patricio; Garland, Justin; Foster, Andrew S. D.; Blecic, Jasmina; Foster, AJ; Smalley, Barry

2015-11-01

WASP-34b is a short-period exoplanet with a mass of 0.59 ± 0.01 Jupiter masses orbiting a G5 star with a period of 4.3177 days and an eccentricity of 0.038 ± 0.012 (Smalley, 2010). We observed WASP-34b using the 3.6 and 4.5 μm channels of the Infrared Array Camera aboard the Spitzer Space Telescope in 2010 (Program 60003). We applied our Photometry for Orbits, Eclipses, and Transits (POET) code to present eclipse-depth measurements, estimates of infrared brightness temperatures, and a refined orbit. With our Bayesian Atmospheric Radiative Transfer (BART) code, we characterized the atmosphere's temperature and pressure profile, and molecular abundances. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G. J. Blecic holds a NASA Earth and Space Science Fellowship.

Saturn Apollo Program

NASA Image and Video Library

1969-07-09

In this photograph, laboratory technician Bart Ruark visually inspects a Japanese Qail confined within a class III cabinet in the Intervertebrae, Aves, and Fish Laboratory of the Lunar Receiving Laboratory, Building 37 of the Manned Spacecraft Center (MSC) in Houston, Texas. This laboratory was part of the overall physical, chemical, and biological test program of the Apollo 11 returned lunar samples. Aboard the Marshall Space Flight Center (MSFC) developed Saturn V launch vehicle, the Apollo 11 mission launched from The Kennedy Space Center, Florida on July 16, 1969 and safely returned to Earth on July 24, 1969. The 3-man crew aboard the flight consisted of astronauts Neil A. Armstrong, commander; Edwin Aldrin, Lunar Module (LM) pilot; and Michael Collins, Command Module (CM) pilot. The CM, piloted by Michael Collins remained in a parking orbit around the Moon while the LM, named “Eagle’’, carrying astronauts Neil Armstrong and Edwin Aldrin, landed on the Moon. In 2 1/2 hours, the crew collected 47 pounds of lunar surface material which was returned to Earth for analysis.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cortiana, Giorgio

We present a measurement of the tmore » $$\\bar{t}$$ production cross section in p$$\\bar{p}$$ collisions at √s = 1.96 TeV which uses for the first time events with a signature of significant missing transverse energy and jets.« less

Systems Analysis of Rapid Transit Underground Construction : Volume 2. Sections 6-9 and Appendixes.

DOT National Transportation Integrated Search

1974-12-01

Three San Francisco Bay Area Rapid Transit (BART) projects and two Washington Metropolitan Area Transit Authority (WMATA) projects are analyzed with respect to time schedules, costs, and sensitivity to physical and institutional controls. These data ...

77 FR 30467 - Approval and Promulgation of Implementation Plans; State of Washington; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-23

.... Visibility impairment is primarily caused by fine particulate matter (PM 2.5 ) or secondary aerosol formed in.... 70 FR 39104. In making a BART applicability determination for a fossil fuel-fired electric generating...

40 CFR 52.1923 - Best Available Retrofit Requirements (BART) for SO2 and Interstate pollutant transport provisions...

Code of Federal Regulations, 2014 CFR

2014-07-01

... combusted at any time at the steam generating unit. Daily average means the arithmetic average of the hourly... which may include, but is not limited to, monitoring results, review of operating and maintenance...

High-definition transcranial direct current stimulation (HD-tDCS) of left dorsolateral prefrontal cortex affects performance in Balloon Analogue Risk Task (BART).

PubMed

Guo, Heng; Zhang, Zhuoran; Da, Shu; Sheng, Xiaotian; Zhang, Xichao

2018-02-01

Studies on risk preferences have long been of great concern and have examined the neural basis underlying risk-based decision making. However, studies using conventional transcranial direct current stimulation (tDCS) revealed that bilateral stimulation could change risk propensity with limited evidence of precisely focalized unilateral high-definition transcranial direct current stimulation (HD-tDCS). The aim of this experiment was to investigate the effect of HD-tDCS focalizing the left dorsal lateral prefrontal cortex (DLPFC) on risk-taking behavior during the Balloon Analogue Risk Task (BART). This study was designed as a between-subject, single-blind, sham-controlled experiment. University students were randomly assigned to three groups: the anodal group (F3 anode, AF3, F1, F5, FC3 returned), the cathodal group (F3 cathodal, AF3, F1, F5, FC3 returned) and the sham group. Subsequently, 1.5-mA 20-min HD-tDCS was applied during the BART, and the Positive Affect and Negative Affect Scale (PANAS), the Sensation Seeking Scale-5 (SSS-5), and the Behavioral Inhibition System and Behavioral Approach System scale (BIS/BAS) were measured as control variables. The cathodal group earned less total money than the sham group, and no significant difference was observed between the anodal group and the sham group. These results showed that, to some extent, focalized unilateral cathodal HD-tDCS on left DLPFC could change performance during risky tasks and diminish risky decision making. Further studies are needed to investigate the dose effect and electrode distribution of HD-tDCS during risky tasks and examine synchronous brain activity to show the neural basis.

N-terminus determines activity and specificity of styrene monooxygenase reductases.

PubMed

Heine, Thomas; Scholtissek, Anika; Westphal, Adrie H; van Berkel, Willem J H; Tischler, Dirk

2017-12-01

Styrene monooxygenases (SMOs) are two-enzyme systems that catalyze the enantioselective epoxidation of styrene to (S)-styrene oxide. The FADH 2 co-substrate of the epoxidase component (StyA) is supplied by an NADH-dependent flavin reductase (StyB). The genome of Rhodococcus opacus 1CP encodes two SMO systems. One system, which we define as E1-type, displays homology to the SMO from Pseudomonas taiwanensis VLB120. The other system, originally reported as a fused system (RoStyA2B), is defined as E2-type. Here we found that E1-type RoStyB is inhibited by FMN, while RoStyA2B is known to be active with FMN. To rationalize the observed specificity of RoStyB for FAD, we generated an artificial reductase, designated as RoStyBart, in which the first 22 amino acid residues of RoStyB were joined to the reductase part of RoStyA2B, while the oxygenase part (A2) was removed. RoStyBart mainly purified as apo-protein and mimicked RoStyB in being inhibited by FMN. Pre-incubation with FAD yielded a turnover number at 30°C of 133.9±3.5s -1 , one of the highest rates observed for StyB reductases. RoStyBart holo-enzyme switches to a ping-pong mechanism and fluorescence analysis indicated for unproductive binding of FMN to the second (co-substrate) binding site. In summary, it is shown for the first time that optimization of the N-termini of StyB reductases allows the evolution of their activity and specificity. Copyright © 2017 Elsevier B.V. All rights reserved.

Toll-like Receptor 2 Signalling and the Lysosomal Machinery in Barrett's Esophagus.

PubMed

Verbeek, Romy E; Siersema, Peter D; Vleggaar, Frank P; Ten Kate, Fiebo J; Posthuma, George; Souza, Rhonda F; de Haan, Judith; van Baal, Jantine W P M

2016-09-01

Inflammation plays an important role in the development of esophageal adenocarcinoma and its metaplastic precursor lesion, Barrett's esophagus. Toll-like receptor (TLR) 2 signalling and lysosomal function have been linked to inflammation-associated carcinogenesis. We examined the expression of TLR2 in the esophagus and the effect of long-term TLR2 activation on morphological changes and expression of factors involved in lysosomal function in a Barrett's esophagus epithelium cell line. TLR2 expression in normal squamous esophagus, reflux esophagitis, Barrett's esophagus and esophageal adenocarcinoma biopsies was assessed with Q-RT-PCR, in situ hybridization and immunohistochemistry. Barrett's esophagus epithelium cells (BAR-T) were incubated with acid and bile salts in the presence or absence of the TLR2 agonist Pam3CSK4 for a period up to 4 weeks. Morphological changes were assessed with electron microscopy, while Q-RT-PCR was used to determine the expression of lysosomal enzymes (Cathepsin B and C) and factors involved in endocytosis (LAMP-1 and M6PR) and autophagy (LC3 and Rab7). TLR2 was expressed in normal squamous esophagus, reflux esophagitis, Barrett's esophagus but was most prominent in esophageal adenocarcinoma. Long-term TLR2 activation in acid and bile salts exposed BAR-T cells resulted in more and larger lysosomes, more mitochondria and increased expression of LAMP-1, M6PR, Cathepsin B and C when compared to BAR-T cells incubated with acid and bile salts but no TLR2 agonist. Factors associated with autophagy (LC3 and Rab7) expression remained largely unchanged. Activation of TLR2 in acid and bile salts exposed Barrett epithelium cells resulted in an increased number of mitochondria and lysosomes and increased expression of lysosomal enzymes and factors involved in endocytosis.

Aeroacoustic Simulation of a Nose Landing Gear in an Open Jet Facility Using FUN3D

NASA Technical Reports Server (NTRS)

Vatsa, Veer N.; Lockard, David P.; Khorrami, Mehdi R.; Carlson, Jan-Renee

2012-01-01

Numerical simulations have been performed for a partially-dressed, cavity-closed nose landing gear configuration that was tested in NASA Langley s closed-wall Basic Aerodynamic Research Tunnel (BART) and in the University of Florida s open-jet acoustic facility known as UFAFF. The unstructured-grid flow solver, FUN3D, developed at NASA Langley Research center is used to compute the unsteady flow field for this configuration. A hybrid Reynolds-averaged Navier-Stokes/large eddy simulation (RANS/LES) turbulence model is used for these computations. Time-averaged and instantaneous solutions compare favorably with the measured data. Unsteady flowfield data obtained from the FUN3D code are used as input to a Ffowcs Williams-Hawkings noise propagation code to compute the sound pressure levels at microphones placed in the farfield. Significant improvement in predicted noise levels is obtained when the flowfield data from the open jet UFAFF simulations is used as compared to the case using flowfield data from the closed-wall BART configuration.

Sex, Drugs and Gluttony: How the Brain Controls Motivated Behaviors

PubMed Central

Hull, Elaine M.

2011-01-01

Bart Hoebel has forged a view of an integrated neural network that mediates both natural rewards and drug use. He pioneered the use of microdialysis, and also effectively used electrical stimulation, lesions, microinjections, and immunohistochemistry. He found that feeding, stimulant drug administration, and electrical stimulation of the lateral hypothalamus (LH) all increased dopamine (DA) release in the nucleus accumbens (NAc). However, whereas DA in the NAc enhanced motivation, DA in the LH inhibited motivated behaviors. The Hull lab has pursued some of those ideas. We have suggested that serotonin (5-HT) in the perifornicalLH inhibits sexual behavior by inhibiting orexin/hypocretin neurons (OX/HCRT), which would otherwise excite neurons in the mesocorticolimbic DA tract. We have shown that DA release in the medial preoptic area (MPOA) is very important for male sexual behavior, and that testosterone, glutamate, nitric oxide (NO) and previous sexual experience promote MPOA DA release and mating. Future research should follow Bart Hoebel’s emphasis on neural systems and interactions among brain areas and neurotransmitters. PMID:21554895

Particulate Matter 2.5 and Black Carbon concentrations in underground San Francisco Bay Area Rapid Transit stations

NASA Astrophysics Data System (ADS)

Gray, A.; Williams, N.; Quartey, R.; Quintana, M.; Bell, B.; Biswas, N.; Hunter, S.; Marks-Block, T.; Yu, X.

2013-12-01

A previous Particulate Matter (PM) 2.5 study within Bay Area Rapid Transit (BART) train stations found that concentrations of PM 2.5 at San Francisco's (SF) Embarcadero station were significantly high relative to within the rail system. To follow up on that study, PM 2.5 data was collected within other underground BART stations and the streets surrounding them using the DustTrak Aerosol monitor that measures concentrations every second. In addition, black carbon (BC) data was collected using a microAeth aerosol monitor that also measures concentrations every minute. During each day that measurements were made along three different train routes originating from West Oakland BART station: 1) toward the San Francisco Civic Center station: en route to the Lake Merritt station in Oakland; and toward the Downtown Berkeley station. All of these stations are located underground, and at each one the DustTrak instrument was taken from the train to the ticket level, and on each route data was collected outside of the stations. Black carbon (BC) concentrations were recorded only on the San Francisco route. The highest PM 2.5 concentrations were recorded at SF underground stations, particularly at Embarcadero where concentrations exceeded 100 μg/m3 at train level. These values were much greater than those obtained outside the station, which ranged between 10-20 μg/m3. Other stations along the route to Civic Center had values ranging from 30-64 μg/m3, higher than stations along the route to the Downtown Berkeley station (17-42 μg/m3 ) and the Lake Merritt station (10-38 μg/m3). PM concentrations outside of stations were lower, ranging from 14-33 μg/m3 and 8-27 μg/m3 outside 12th Street Oakland City Center and Lake Merritt stations respectively. Additionally, PM concentration was directly related to depth at all stations. For example, one day at Embarcadero the highest concentrations from train to middle to top level were 119, 84, and 59 μg/m3 respectively. We believe the differences in PM concentration between stations are attributed to the number of train lines at each station, the length of adjacent train tunnel, and access to open air at each station. Discussion of PM sources and BC data awaits further elemental analysis of particles collected on instruments' filters. Twenty-four hour sampling of underground BART station air quality is recommended to further understand long-term patterns and potential exposure risks to employees and commuters.

KSC-2012-2141

NASA Image and Video Library

2012-04-14

CAPE CANAVERAL, Fla. – At the Shuttle Landing Facility at NASA’s Kennedy Space Center in Florida, media representatives interview space shuttle managers following the arrival of space shuttle Discovery. Behind the rope with their backs to the camera are, from left, Bart Pannullo, NASA Transition and Retirement vehicle manager at Kennedy Dorothy Rasco, manager for Space Shuttle Program Transition and Retirement at NASA’s Johnson Space Center Stephanie Stilson, NASA flow director for Orbiter Transition and Retirement at Kennedy and Kevin Templin, transition manager for the Space Shuttle Program at Johnson. Discovery will be hoisted onto a Shuttle Carrier Aircraft, or SCA, with the aid of the mate-demate device at the landing facility. The SCA, a modified Boeing 747 jet airliner, is scheduled to ferry Discovery to the Washington Dulles International Airport in Virginia on April 17, after which the shuttle will be placed on permanent public display in the Smithsonian's National Air and Space Museum Steven F. Udvar-Hazy Center. For more information on shuttle transition and retirement activities, visit http://www.nasa.gov/transition. Photo credit: NASA/Kim Shiflett

78 FR 41731 - Source Specific Federal Implementation Plan for Implementing Best Available Retrofit Technology...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-11

... Federal Implementation Plan for Implementing Best Available Retrofit Technology for Four Corners Power... Implementation Plan (FIP) to implement the Best Available Retrofit Technology (BART) requirement of the Regional... given the uncertainties in the electrical market in Arizona, EPA is proposing to extend the date by...

The Priscilla and Bart Bok Award, presented by the ASP and the AAS at the Intel International Science and Engineering Fair

NASA Astrophysics Data System (ADS)

Garmany, K.

2013-04-01

The Bok Award is presented to high school students for astronomy research. While there are relatively few astronomy projects at this fair, many of the winners of this award have continued in the field of astronomy.

Solid State Research

DTIC Science & Technology

1992-02-15

Appl. Phys. Lett. 59, 2634 Increased Lifetime Obtained by Using C. A. Wang (1991) Strained InGaAs Active Layer N. H. Karam* Piezoelectric Micromotors ... Micromotors J. Chen* K. G. Brooks* L. E. Cross* A. M. Flynn* S. F. Bart* L. S. Tavrow* R. A. Brooks* D. J. Ehrlich *Author not at Lincoln Laboratory

77 FR 25660 - State of Nevada; Regional Haze State and Federal Implementation Plans; BART Determination for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-01

... 2400 St. Joseph Street in Overton, Nevada, with an open house at the same location. This hearing will... School on 2400 St. Joseph Street in Overton, Nevada from 6:30 p.m. to 8:30 p.m. on May 3, 2012, with an...

Thermal Energy Briefing with FPL

NASA Image and Video Library

2017-02-17

Bart Gaetjens, Florida Power & Light's FPL area external affairs manager, addresses the news media and NASA Social about the new Thermal Energy Storage (TES) tank Feb. 17. The TES tank works like a giant battery and is saving the center utility cost. These savings will be applied to new sustainable projects at Kennedy.

77 FR 75703 - Partial Approval and Disapproval of Air Quality Implementation Plans; Arizona; Regional Haze and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-21

... action includes all portions of the SIP except for three electric generating stations that were addressed... Arizona's Best Available Retrofit Technology (BART) control analysis and determinations, Reasonable... refer to Best Available Retrofit Technology. (6) The term Class I area refers to a mandatory Class I...

78 FR 51686 - Approval and Promulgation of Implementation Plans; Oklahoma; Regional Haze and Interstate...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-21

... American Electric Power/Public Service Company of Oklahoma AGENCY: Environmental Protection Agency (EPA... addressing the Best Available Retrofit Technology (BART) requirements for sulfur dioxide (SO 2 ) and oxides of nitrogen (NO X ) for Units 3 and 4 of the American Electric Power/Public Service Company (AEP/PSO...

78 FR 34737 - Approval, Disapproval and Promulgation of Implementation Plans; State of Wyoming; Regional Haze...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-10

... goal of achieving natural visibility conditions in Class I areas. EPA is taking this action pursuant to..., Natural, and Current Visibility Conditions C. Determination of Reasonable Progress Goals D. Best Available... Class I Areas B. Baseline Visibility, Natural Visibility, and Uniform Rate of Progress C. BART...

75 FR 3962 - Notice of Availability of a Record of Decision (ROD) for the Proposed Bay Area Rapid Transit...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-25

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Notice of Availability of a Record of... Airport (OAK), Oakland, Alameda County, CA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... public that it has issued a ROD for the proposed construction and operation of the proposed BART...

76 FR 38997 - Approval and Promulgation of Implementation Plans; State of Oregon; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-05

... economic blow that would result from an earlier closure and is an appropriate balance of environmental and... BART rules for the Boardman facility achieve the proper balance of environmental benefits, the cost to... secure greater environmental benefits with a better balance of cost and risk by transitioning the...

Every Teacher Carries a Leadership Wand

ERIC Educational Resources Information Center

Tubin, Dorit

2017-01-01

Turnaround schools require empowered teachers to discover their leadership wand. Based on a case study conducted on BART Charter School, this article highlights five steps for leaders who wish to empower their teachers and allow them to lead their schools to success: (1) Let your people know; (2) Nominate the fittest, (3) Connect teachers to a…

78 FR 8273 - Approval of Air Quality Implementation Plans; Navajo Nation; Regional Haze Requirements for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-05

... in significant visibility improvement that is well-balanced with the cost of those controls. For a... visibility benefits over time and that there may be changes in energy demand, supply or other developments... encourages a robust public discussion of our proposed BART determination and alternative, the additional...

ATS Information Exchange

NASA Astrophysics Data System (ADS)

Breyer, Walter H.

Questions answered on: telescope maker Emile Schaer by Christof Plicht, Peter Abrahams and Robert B. Ariail; the firm of Gall and Lembke, NY by Bart Fried; Bonn Double Refractor (Repsold factory, Steinheil optics) by Michael Geffert; Foucault Eyepiece by Eugene Rudd; Ross Evans spyglass by R.C. Blankenhorn; and a Moralee nautical spyglass by Willem M. Bruyns

Chartering New Waters: The Indianapolis Mayoral Transition and the Charter School Community

ERIC Educational Resources Information Center

Prusinski, Ellen L.; Ruddy, Anne-Maree; Plucker, Jonathan A.; Cierniak, Katherine A.

2015-01-01

As the first mayor in the United States to possess independent charter school authorizing authority, Mayor Bart Peterson oversaw the establishment and expansion of Indianapolis's ambitious charter school initiative. In 2007, Democratic Mayor Peterson's oversight of the initiative came to an end when he was unexpectedly defeated by Republican…

78 FR 79344 - Approval and Promulgation of Implementation Plans; State of Washington; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-30

... comment. Electronic files should avoid the use of special characters, any form of encryption, and be free..., will be publicly available only in hard copy form. Publicly available docket materials are available... for each applicable source. In making a BART-applicability determination for a fossil fuel-fired...

40 CFR 52.1923 - Best Available Retrofit Requirements (BART) for SO2 and Interstate pollutant transport provisions...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Sooner plant; and Units 3 and 4 of the American Electric Power/Public Service Company of Oklahoma... American Electric Power/Public Service Company of Oklahoma Northeastern plant affecting visibility? (a... American Electric Power/Public Service Company of Oklahoma Northeastern plant. (b) Compliance dates...

40 CFR 52.1923 - Best Available Retrofit Requirements (BART) for SO2 and Interstate pollutant transport provisions...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Sooner plant; and Units 3 and 4 of the American Electric Power/Public Service Company of Oklahoma... American Electric Power/Public Service Company of Oklahoma Northeastern plant affecting visibility? (a... American Electric Power/Public Service Company of Oklahoma Northeastern plant. (b) Compliance Dates...

77 FR 4735 - Regional Haze: Revisions to Provisions Governing Alternatives to Source-Specific Best Available...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-31

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Parts 51 and 52 [EPA-HQ-OAR-2011-0729; FRL-9624-4] RIN 2060-AR05 Regional Haze: Revisions to Provisions Governing Alternatives to Source-Specific Best Available Retrofit Technology (BART) Determinations, Limited SIP Approvals, and Federal Implementation Plans AGENCY...

In my experience: quality control of symposia and their published proceedings

Treesearch

J. Michael Scott; C. John Ralph

1988-01-01

The lack of quality in symposia proceedings has recently been criticized by Bart and Anderson (1981). Their criticisms elicited 2 defenses of publishing symposia proceedings (Ca- pen 1982, Finch et al. 1982). These authors offered excellent suggestions for improving the quality of published proceedings: review papers before acceptance; use outside reviewers; request...

77 FR 39938 - Approval and Promulgation of Air Quality Implementation Plans; Maryland; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... responses are provided below. Comment 1: The Commenter recommended that emission controls for a coal... Dakota. The Commenter stated that initially the coal cleaning facility was identified as BART-eligible... further evaluate controls at the coal cleaning facility and the three EGUs under the reasonable progress...

Investigating Alternatives to Broad-Scale Pesticide Spraying for Control of Lyme Disease Risk

EPA Science Inventory

More than 20,000 cases of Lyme disease are reported annually in the US. Here in the Northeast, the geographic range of the disease and infection rates continue to increase. Beginning this summer, scientists from EPA Region 1 (Robert Koethe, Bart Hoskins) and ORD (Jason Grear) w...

Defense Acquisition: Observations Two Years After the Packard Commission

DTIC Science & Technology

1988-11-01

AiSTER THE PACKARD COMMISSION, VOLUME 1: MAIN REPORT 12 . .L = (ýesce Kanter, Bart.ar Bicksler, H. Marshall Hoyler, Robert Hilton, Walter Locke, George...Organization in the Military Services ..............-.... M 12 D. Summary ............................................................................. 1-17...IV- 12 B. The Resource Allocation Process ............................ IV-14 1. T1z Planning Phase

76 FR 491 - Approval and Promulgation of Implementation Plans; New Mexico; Federal Implementation Plan for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-05

... Pollution Affecting Visibility and Best Available Retrofit Technology Determination AGENCY: Environmental... technology (BART) for NO X for this source. This action is being taken under section 110 and part C of the.... Visibility Protection 3. Best Available Retrofit Technology 4. The Western Regional Air Partnership and...

Exposure to bright light biases effort-based decisions.

PubMed

Bijleveld, Erik; Knufinke, Melanie

2018-06-01

Secreted in the evening and the night, melatonin suppresses activity of the mesolimbic dopamine pathway, a brain pathway involved in reward processing. However, exposure to bright light diminishes-or even prevents-melatonin secretion. Thus, we hypothesized that reward processing, in the evening, is more pronounced in bright light (vs. dim light). Healthy human participants carried out three tasks that tapped into various aspects of reward processing (effort expenditure for rewards task [EEfRT]; two-armed bandit task [2ABT]; balloon analogue risk task [BART). Brightness was manipulated within-subjects (bright vs. dim light), in separate evening sessions. During the EEfRT, participants used reward-value information more strongly when they were exposed to bright light (vs. dim light). This finding supported our hypothesis. However, exposure to bright light did not significantly affect task behavior on the 2ABT and the BART. While future research is necessary (e.g., to zoom in on working mechanisms), these findings have potential implications for the design of physical work environments. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

When do traumatic experiences alter risk-taking behavior? A machine learning analysis of reports from refugees.

PubMed

Augsburger, Mareike; Elbert, Thomas

2017-01-01

Exposure to traumatic stressors and subsequent trauma-related mental changes may alter a person's risk-taking behavior. It is unclear whether this relationship depends on the specific types of traumatic experiences. Moreover, the association has never been tested in displaced individuals with substantial levels of traumatic experiences. The present study assessed risk-taking behavior in 56 displaced individuals by means of the balloon analogue risk task (BART). Exposure to traumatic events, symptoms of posttraumatic stress disorder and depression were assessed by means of semi-structured interviews. Using a novel statistical approach (stochastic gradient boosting machines), we analyzed predictors of risk-taking behavior. Exposure to organized violence was associated with less risk-taking, as indicated by fewer adjusted pumps in the BART, as was the reported experience of physical abuse and neglect, emotional abuse, and peer violence in childhood. However, civil traumatic stressors, as well as other events during childhood were associated with lower risk taking. This suggests that the association between global risk-taking behavior and exposure to traumatic stress depends on the particular type of the stressors that have been experienced.

Sex, drugs and gluttony: how the brain controls motivated behaviors.

PubMed

Hull, Elaine M

2011-07-25

Bart Hoebel has forged a view of an integrated neural network that mediates both natural rewards and drug use. He pioneered the use of microdialysis, and also effectively used electrical stimulation, lesions, microinjections, and immunohistochemistry. He found that feeding, stimulant drug administration, and electrical stimulation of the lateral hypothalamus (LH) all increased dopamine (DA) release in the nucleus accumbens (NAc). However, whereas DA in the NAc enhanced motivation, DA in the LH inhibited motivated behaviors. The Hull lab has pursued some of those ideas. We have suggested that serotonin (5-HT) in the perifornical LH inhibits sexual behavior by inhibiting orexin/hypocretin neurons (OX/HCRT), which would otherwise excite neurons in the mesocorticolimbic DA tract. We have shown that DA release in the medial preoptic area (MPOA) is very important for male sexual behavior, and that testosterone, glutamate, nitric oxide (NO) and previous sexual experience promote MPOA DA release and mating. Future research should follow Bart Hoebel's emphasis on neural systems and interactions among brain areas and neurotransmitters. Copyright © 2011 Elsevier Inc. All rights reserved.

Measurement of the correlation between the polar angles of leptons from top quark decays in the helicity basis at √s=7 TeV using the ATLAS detector

DOE PAGES

Aad, G.; Abbott, B.; Abdallah, J.; ...

2016-01-13

A measurement of the correlations between the polar angles of leptons from the decay of pair-produced t andmore » $$\\bar{t}$$ quarks in the helicity basis is reported, using proton-proton collision data collected by the ATLAS detector at the LHC. The dataset corresponds to an integrated luminosity of 4.6 fb -1 at a center-of-mass energy of √s=7 TeV collected during 2011. Candidate events are selected in the dilepton topology with large missing transverse momentum and at least two jets. The angles θ1 and θ2 between the charged leptons and the direction of motion of the parent quarks in the t$$\\bar{t}$$ rest frame are sensitive to the spin information, and the distribution of cosθ 1•cosθ 2 is sensitive to the spin correlation between the t and $$\\bar{t}$$ quarks. The distribution is unfolded to parton level and compared to the next-to-leading order prediction. A good agreement is observed.« less

Autocrine Extra-Pancreatic Trypsin 3 Secretion Promotes Cell Proliferation and Survival in Esophageal Adenocarcinoma

PubMed Central

Han, Song; Lee, Constance W.; Trevino, Jose G.; Hughes, Steven J.; Sarosi, George A.

2013-01-01

Trypsin or Tumor associated trypsin (TAT) activation of Protease-activated receptor 2 (PAR-2) promotes tumor cell proliferation in gastrointestinal cancers. The role of the trypsin/PAR-2 network in esophageal adenocarcinoma (EA) development has not yet been investigated. The aim of this study is to investigate the role of trypsin/PAR-2 activation in EA tumorogenesis and therapy. We found that esophageal adenocarcinoma cells (EACs) and Barrett’s Metaplasia (BART) expressed high levels of type 3 extra-pancreatic trypsinogen (PRSS3), a novel type of TAT. Activity of secreted trypsin was detected in cultured media from EA OE19 and OE33 cultures but not from BART culture. Surface PAR-2 expression in BART and EACs was confirmed by both flow cytometry and immunofluorescence. Trypsin induced cell proliferation (∼ 2 fold; P<0.01) in all tested cell lines at a concentration of 10 nM. Inhibition of PAR-2 activity in EACs via the PAR-2 antagonist ENMD (500 µM), anti-PAR2 antibody SAM-11 (2 µg/ml), or siRNA PAR-2 knockdown, reduced cell proliferation and increased apoptosis by up to 4 fold (P<0.01). Trypsin stimulation led to phosphorylation of ERK1/2, suggesting involvement of MAPK pathway in PAR-2 signal transduction. Inhibition of PAR-2 activation or siRNA PAR-2 knockdown in EACs prior to treatment with 5 FU reduced cell viability of EACs by an additional 30% (P<0.01) compared to chemotherapy alone. Our data suggest that extra-pancreatic trypsinogen 3 is produced by EACs and activates PAR-2 in an autocrine manner. PAR-2 activation increases cancer cell proliferation, and promotes cancer cell survival. Targeting the trypsin activated PAR-2 pathway in conjunction with current chemotherapeutic agents may be a viable therapeutic strategy in EA. PMID:24146905

77 FR 14603 - Approval and Promulgation of Implementation Plans; Arkansas; Regional Haze State Implementation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-12

...The EPA is partially approving and partially disapproving a revision to the Arkansas State Implementation Plan (SIP) intended to address the regional haze (RH) requirements of the Clean Air Act (CAA or Act). In addition, EPA is partially approving and partially disapproving the portion of the Arkansas Interstate Transport SIP submittal that addresses the visibility requirement of section 110(a)(2)(D)(i)(II) for the 1997 8-hour ozone and 1997 fine particulate matter (PM2.5) national ambient air quality standards (NAAQS) that the Arkansas SIP contain adequate provisions to prohibit emissions from interfering with measures required in another state to protect visibility. EPA is approving certain core elements of the RH SIP including: identification of affected Class I areas; determination of baseline and natural visibility conditions; determination of Uniform Rate of Progress (URP); reasonable progress goal (RPG) consultation and long term strategy (LTS) consultation; coordination of RH and reasonably attributable visibility impairment (RAVI); regional haze monitoring strategy and other SIP requirements under 40 CFR 51.308(d)(4); commitment to submit periodic regional haze SIP revisions and periodic progress reports describing progress towards the RPGs; commitment to make a determination of the adequacy of the existing SIP at the time a progress report is submitted; and consultation and coordination with Federal land managers (FLMs). EPA is partially approving and partially disapproving portions of other core elements of the SIP including: identification of best available retrofit technology (BART) eligible sources and subject to BART sources; requirements for BART; Chapter 15 of the Air Pollution Control and Ecology Commission (APCEC) Regulation No. 19, also known as the State's RH Rule; and the LTS. EPA is disapproving Arkansas's reasonable progress goals (RPGs) required under 40 CFR 51.308(d)(1). This action is being taken under section 110 and part C of the CAA.

Logistics During Grant’s Vicksburg Campaign

DTIC Science & Technology

1992-04-15

cargo . Grant was now ready to attack Vicksburg’s vulnerable southern flank planning to move through the swamps west -,f the Mississippi to New...iCiar: .: aFhid .-::tret t win bart les and. in -the eri-. w l _th ,:’Lr-,r and pat ,?mbat leaers dwell upon ,.heir suceses a ri if the issue of I

77 FR 34218 - Approval and Promulgation of Air Quality Implementation Plans; Indiana; Regional Haze

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-11

... in the sulfur content of coke for the BART-subject potlines ( 2- 6), actually results in increased SO... low sulfur coke may not be available after 2013, but asserts that if increased emissions from the... an increase in sulfur content of coke used in the potlines, but Indiana's submittal does not actually...

77 FR 34801 - Approval and Promulgation of Air Quality Implementation Plans; Minnesota; Regional Haze

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-12

... provisions related to BART. EPA proposed approval of the Minnesota regional haze plan on January 25, 2012 (77... finalizing that rule on May 30, 2012, EPA responded to similar comments in the context of that rulemaking... Royale National Park, and Voyageurs National Park. Response: EPA is committed to the goal of the regional...

76 FR 30936 - West Maui Pumped Storage Water Supply, LLC; Notice of Preliminary Permit Application Accepted for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-27

... Storage Water Supply, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...-acre reservoir; (4) a turnout to supply project effluent water to an existing irrigation system; (5) a...,000 megawatt-hours. Applicant Contact: Bart M. O'Keeffe, West Maui Pumped Storage Water Supply, LLC, P...

76 FR 28025 - East Maui Pumped Storage Water Supply LCC; Notice of Preliminary Permit Application Accepted for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-13

... Storage Water Supply LCC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting... Act (FPA), proposing to study the feasibility of the East Maui Pumped Storage Water Supply Project to.... Bart M. O'Keeffe, East Maui Pumped Storage Water Supply LLC; P.O. Box 1916; Discovery Bay, CA 94505...

77 FR 72742 - Approval and Promulgation of State Implementation Plans: State of Washington; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-06

... Ecology (Ecology) submitted its Regional Haze State Implementation Plan (SIP) on December 22, 2010 to meet... Ecology submitted an update to the SIP submittal containing a revised and updated BART determination for... organized as follows: I. What is the background for this final action? Ecology submitted its Regional Haze...

77 FR 23191 - State of Nevada; Regional Haze State and Federal Implementation Plans; BART Determination for...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-18

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 [EPA-R9-OAR-2011-0130; FRL-9661-4] State of Nevada... Station AGENCY: Environmental Protection Agency (EPA). ACTION: Announcement of public hearing. SUMMARY... on May 3, 2012. ADDRESSES: We will hold a public hearing at Moapa Valley Empowerment High School...

78 FR 58987 - Approval of Air Quality Implementation Plans; Navajo Nation; Regional Haze Requirements for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-25

... hold five public hearings to accept written and oral comment on our proposed BART determination for NGS. On July 26, 2013, a group of stakeholders, known as the Technical Work Group (TWG), submitted its... included as part of the public comment. If EPA cannot read your comment due to technical difficulties and...

Understanding and Harnessing the Power of Ideas, Persuasion, and Trust 2.0

DTIC Science & Technology

2014-03-01

15 Festive Dinner: Asian Civilisations Museum...Opening Session 08:30 - 17:30 Keynote Presentation Pa per Presenta tion Sessions Round Table Sessions 18:00 - 22:00 Festive Dinner, Asia n...reciprocity. Bart Vonneste (University College l ondon) Festive Dinner (I B:OO - 20:00: Tours, drinks, and hors d’oeuvres) (20:00 onward~: Dinner

76 FR 82219 - Regional Haze: Revisions to Provisions Governing Alternatives to Source-Specific Best Available...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-30

...., Washington, DC 20460. Please include a total of two copies. Hand Delivery: U.S. Environmental Protection.... Explain your views as clearly as possible, avoiding the use of profanity or personal threats. Make sure to... Approvable Alternative to BART A. Application of the Two-Pronged Test B. Identification of Affected Class I...

Neural Correlates of Traditional Chinese Medicine Induced Advantageous Risk-Taking Decision Making

ERIC Educational Resources Information Center

Lee, Tiffany M. Y.; Guo, Li-guo; Shi, Hong-zhi; Li, Yong-zhi; Luo, Yue-jia; Sung, Connie Y. Y.; Chan, Chetwyn C. H.; Lee, Tatia M. C.

2009-01-01

This fMRI study examined the neural correlates of the observed improvement in advantageous risk-taking behavior, as measured by the number of adjusted pumps in the Balloon Analogue Risk Task (BART), following a 60-day course of a Traditional Chinese Medicine (TCM) recipe, specifically designed to regulate impulsiveness in order to modulate…

The Concentration of Nutrients in Tissues of Plantation-Grown Eastern Cottonwood (Populus deltoides Bart.)

Treesearch

M. G. Shelton; L. E. Nelson; G. L. Switzer; B. G. Blackmon

1981-01-01

Nutrient concentrations were determined for 10 tissues from each of 24 cottonwood trees that ranged in age from four to 16 years. Highest concentrations occurred in the most physiologically active tissues; i.e., stemtips, current branches and foliage. Tree age had little influence on the variation in nutrient concentration of tissues. Some differences in concentrations...

77 FR 17334 - Approval and Promulgation of Air Quality Implementation Plans; State of Nevada; Regional Haze...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-26

... Progress Goal B. Long-Term Strategy C. BART for SO 2 and PM 10 at Reid Gardner D. Corrections to EPA's... a long- term strategy with enforceable measures to ensure reasonable progress toward achieving the... corresponding emission limits and schedules of compliance for NO X at RGGS in the SIP's long-term strategy...

When do traumatic experiences alter risk-taking behavior? A machine learning analysis of reports from refugees

PubMed Central

Augsburger, Mareike; Elbert, Thomas

2017-01-01

Exposure to traumatic stressors and subsequent trauma-related mental changes may alter a person’s risk-taking behavior. It is unclear whether this relationship depends on the specific types of traumatic experiences. Moreover, the association has never been tested in displaced individuals with substantial levels of traumatic experiences. The present study assessed risk-taking behavior in 56 displaced individuals by means of the balloon analogue risk task (BART). Exposure to traumatic events, symptoms of posttraumatic stress disorder and depression were assessed by means of semi-structured interviews. Using a novel statistical approach (stochastic gradient boosting machines), we analyzed predictors of risk-taking behavior. Exposure to organized violence was associated with less risk-taking, as indicated by fewer adjusted pumps in the BART, as was the reported experience of physical abuse and neglect, emotional abuse, and peer violence in childhood. However, civil traumatic stressors, as well as other events during childhood were associated with lower risk taking. This suggests that the association between global risk-taking behavior and exposure to traumatic stress depends on the particular type of the stressors that have been experienced. PMID:28498865

Real and hypothetical monetary rewards modulate risk taking in the brain.

PubMed

Xu, Sihua; Pan, Yu; Wang, You; Spaeth, Andrea M; Qu, Zhe; Rao, Hengyi

2016-07-07

Both real and hypothetical monetary rewards are widely used as reinforcers in risk taking and decision making studies. However, whether real and hypothetical monetary rewards modulate risk taking and decision making in the same manner remains controversial. In this study, we used event-related potentials (ERP) with a balloon analogue risk task (BART) paradigm to examine the effects of real and hypothetical monetary rewards on risk taking in the brain. Behavioral data showed reduced risk taking after negative feedback (money loss) during the BART with real rewards compared to those with hypothetical rewards, suggesting increased loss aversion with real monetary rewards. The ERP data demonstrated a larger feedback-related negativity (FRN) in response to money loss during risk taking with real rewards compared to those with hypothetical rewards, which may reflect greater prediction error or regret emotion after real monetary losses. These findings demonstrate differential effects of real versus hypothetical monetary rewards on risk taking behavior and brain activity, suggesting a caution when drawing conclusions about real choices from hypothetical studies of intended behavior, especially when large rewards are used. The results have implications for future utility of real and hypothetical monetary rewards in studies of risk taking and decision making.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hurlbut, D. J.; Haase, S.; Turchi, C. S.

In January 2012, the National Renewable Energy Laboratory delivered to the Department of the Interior the first part of a study on Navajo Generating Station (Navajo GS) and the likely impacts of BART compliance options. That document establishes a comprehensive baseline for the analysis of clean energy alternatives, and their ability to achieve benefits similar to those that Navajo GS currently provides. This analysis is a supplement to NREL's January 2012 study. It provides a high level examination of several clean energy alternatives, based on the previous analysis. Each has particular characteristics affecting its relevance as an alternative to Navajomore » GS. It is assumed that the development of any alternative resource (or portfolio of resources) to replace all or a portion of Navajo GS would occur at the end of a staged transition plan designed to reduce economic disruption. We assume that replacing the federal government's 24.3% share of Navajo GS would be a cooperative responsibility of both the U.S. Bureau of Reclamation (USBR) and the Central Arizona Water Conservation District (CAWCD).« less

Proceedings of the Midwest Research-to-Practice Conference in Adult and Continuing Education (3rd, DeKalb, Illinois, September 27-28, 1984).

ERIC Educational Resources Information Center

Northern Illinois Univ., De Kalb. Coll. of Continuing Education.

These proceedings consist of 28 presentations. They include, in alphabetical order by author, "Data Collection Methods Used to Determine Training Needs of the Organization and the Adult Learner in Business and Industry" (Bart P. Beaudin), "Sex and the Split Brain: Does the Sex of the Mind Matter?" (Anne A. Bowbeer),…

78 FR 24700 - Approval and Promulgation of Implementation Plans; North Dakota; Regional Haze State...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-26

... (NO X ) for Milton R. Young Station Units 1 and 2 and Leland Olds Station Unit 2, which are coal-fired... approval of North Dakota's BART emission limits for NO X for Milton R. Young Station Units 1 and 2 and... appropriate. The limitation is to ensure that everyone who wants to make comments has the opportunity to do so...

An Experimental Study of Risk Taking Behavior among Adolescents: A Closer Look at Peer and Sex Influences

ERIC Educational Resources Information Center

de Boer, Anouk; Peeters, Margot; Koning, Ina

2017-01-01

In this experimental study, it was examined to what extent peers and sex were important predictors of risk taking behavior of adolescents. Participants were 140 Dutch adolescents (52.9% boys, 12-15 years) who completed the Balloon Analogue Risk Task (BART) as a measure of risk taking behavior, either individually or in the presence of homogenous…

77 FR 3712 - Approval and Promulgation of Air Quality Implementation Plans; Ohio; Regional Haze

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-25

... equal incremental change in visibility perceived by the human eye. Most people can detect a change in... desulfurization (FGD), semi-dry FGD, and over-fire air (OFA) with a sorbent injection system (SIS). Ohio and MPRO... on up to 7 days a year. Ohio selected semi-dry FGD as the BART SO 2 control, which is expected to...

Enhancing the value of the breeding bird survey: reply to Sauer et al. (2005)

Treesearch

Charles M. Francis; Jonathan Bart; Erica H. Dunn; Kenneth P. Burnham; C. John Ralph

2005-01-01

Bart et al (2004a) proposed several approaches for enhancing the considerable value of the Breeding Bird Survey (BBS). Sauer et al. (2005) critiqued some of these approaches, and emphasized alternative goals for the survey. We agree with many of the suggestions of Sauer et al. (2005); notably that multispecies, large-scale surveys such as the BBS are most valuable for...

L2 Reading Research and Pedagogical Considerations in the Teaching of French and Francophone Theater

ERIC Educational Resources Information Center

Edwards, Carole; Taylor, Alan M.

2012-01-01

Little research on improving second language (L2) reading comprehension of French and francophone theater has been conducted. This study provides insight into enhancing L2 comprehension of drama by combining L2 research with examples from L'accent grave by Jacques Prevert, Ton beau capitaine by Simone Schwarz-Bart (1987), Un Touareg s'est marie a…

Differential associations between impulsivity and risk-taking and brain activations underlying working memory in adolescents.

PubMed

Panwar, Karni; Rutherford, Helena J V; Mencl, W Einar; Lacadie, Cheryl M; Potenza, Marc N; Mayes, Linda C

2014-11-01

Increased impulsivity and risk-taking are common during adolescence and relate importantly to addictive behaviors. However, the extent to which impulsivity and risk-taking relate to brain activations that mediate cognitive processing is not well understood. Here we examined the relationships between impulsivity and risk-taking and the neural correlates of working memory. Neural activity was measured in 18 adolescents (13-18 years) while they engaged in a working memory task that included verbal and visuospatial components that each involved encoding, rehearsal and recognition stages. Risk-taking and impulsivity were assessed using the Balloon Analogue Risk Task (BART) and the adolescent version of the Barratt Impulsiveness Scale-11 (BIS-11A), respectively. We found overlapping as well as distinct regions subserving the different stages of verbal and visuospatial working memory. In terms of risk-taking, we found a positive correlation between BART scores and activity in subcortical regions (e.g., thalamus, dorsal striatum) recruited during verbal rehearsal, and an inverse correlation between BART scores and cortical regions (e.g., parietal and temporal regions) recruited during visuospatial rehearsal. The BIS-11A evidenced that motor impulsivity was associated with activity in regions recruited during all stages of working memory, while attention and non-planning impulsivity was only associated with activity in regions recruited during recognition. In considering working memory, impulsivity and risk-taking together, both impulsivity and risk-taking were associated with activity in regions recruited during rehearsal; however, during verbal rehearsal, differential correlations were found. Specifically, positive correlations were found between: (1) risk-taking and activity in subcortical regions, including the thalamus and dorsal striatum; and, (2) motor impulsivity and activity in the left inferior frontal gyrus, insula, and dorsolateral prefrontal cortex. Therefore these findings suggest that while there may be some overlap in the neural correlates of working memory and their relationship to impulsivity and risk-taking, there are also important differences in these constructs and their relationship to the stages of working memory during adolescence. Copyright © 2013 Elsevier Ltd. All rights reserved.

Differential associations between impulsivity and risk-taking and brain activations underlying working memory in adolescents

PubMed Central

Panwar, Karni; Rutherford, Helena J.V.; Mencl, W. Einar; Lacadie, Cheryl M.; Potenza, Marc N.; Mayes, Linda C.

2014-01-01

Increased impulsivity and risk-taking are common during adolescence and relate importantly to addictive behaviors. However, the extent to which impulsivity and risk-taking relate to brain activations that mediate cognitive processing is not well understood. Here we examined the relationships between impulsivity and risk-taking and the neural correlates of working memory. Neural activity was measured in 18 adolescents (13–18 years) while they engaged in a working memory task that included verbal and visuospatial components that each involved encoding, rehearsal and recognition stages. Risk-taking and impulsivity were assessed using the Balloon Analogue Risk Task (BART) and the adolescent version of the Barratt Impulsiveness Scale -11 (BIS-11A), respectively. We found overlapping as well as distinct regions subserving the different stages of verbal and visuospatial working memory. In terms of risk-taking, we found a positive correlation between BART scores and activity in subcortical regions (e.g., thalamus, dorsal striatum) recruited during verbal rehearsal, and an inverse correlation between BART scores and cortical regions (e.g., parietal and temporal regions) recruited during visuospatial rehearsal. The BIS-11A evidenced that motor impulsivity was associated with activity in regions recruited during all stages of working memory, while attention and non-planning impulsivity was only associated with activity in regions recruited during recognition. In considering working memory, impulsivity and risk-taking together, both impulsivity and risk-taking were associated with activity in regions recruited during rehearsal; however, during verbal rehearsal, differential correlations were found. Specifically, positive correlations were found between: (1) risk-taking and activity in subcortical regions, including the thalamus and dorsal striatum; and, (2) motor impulsivity and activity in the left inferior frontal gyrus, insula, dorsolateral and ventrolateral prefrontal cortex. Therefore these findings suggest that while there may be some overlap in the neural correlates of working memory and their relationship to impulsivity and risk-taking, there are also important differences in these constructs and their relationship to the stages of working memory during adolescence. PMID:24582821

Atropine Pharmacokinetics are Affected by Moderate Hemorrhage and Hypothyroidism

DTIC Science & Technology

1989-12-01

Moderate Hemorrhage and Hypothyroidism 12. PERSONAL AUTHOR(S) R.C. Smallridge, B. Chernow, S. Teich, C. Kinzer, C. Umstott, G. Geelhoed, _ Ppmnl i n 13a...moderate hemorrhage and hypothyroidism ROBERT C. SMALLRIDGE, MD: BART CHERNOW, MD: STEVEN TEICH, MD, CAROL KINZER: CAROLYN UMSTOTT: GLEN GEELHOED. MD...under two experimental conditions, moderate hem- sweating) are known (1-5). orrhage and hypothyroidism , to determine whether im A number of situations

Laser System Usage in the Marine Environment: Applications and Environmental Considerations

DTIC Science & Technology

2010-12-01

publications/pubs/index.html. Released by Bart Chadwick, Head Environmental Sciences Branch Under authority of Martin Machniak, Head Research...Nilsson and Lindstrom , 1983; Shelton, Gaten, and Chapman, 1985). Data on the effects of laser energy to corals also are lacking, although it can be...L. and M. Lindstrom . 1983. “Retinal Damage and Sensitivity Loss of a Light- Sensitive Crustacean Compound Eye (Cirolana borealis): Electron

A Classroom Exercise for Testing Urban Myth: Does Wedding Rice Cause Birds to Explode or Were Ann Landers, Martha Stewart & Bart Simpson Wrong?

ERIC Educational Resources Information Center

Krupa, James J.

2005-01-01

In this article, the author first provides the history of the wedding rice myth. He then details an interactive class activity that involved students in his large, non-majors biology classes. These students developed a series of experiments that scientifically determined if rice could be harmful to birds. Finally, he provides suggestions on how…

Assessing the use of Low Voltage UV-light Emitting Miniature LEDs for Marine Biofouling Control

DTIC Science & Technology

2016-07-01

Piola, 1Bart Salters, Clare Grandison, Mark Ciacic and 1Roelant Hietbrink Maritime Division Defence Science and Technology Group 1Philips...uniformly all over the coating layer. In this report, we present a description of the technology and experimental setup, as well as the results of...UNCLASSIFIED Published by Maritime Division Defence Science and Technology Group 506 Lorimer St Fishermans Bend, Victoria 3207 Australia

Effects of acute and chronic caffeine on risk-taking behavior in children and adolescents.

PubMed

Temple, Jennifer L; Ziegler, Amanda M; Graczyk, Adam M; Crandall, Amanda

2017-05-01

Consumption of caffeinated beverages is associated with increased risk-taking behavior. The purpose of this study was to determine if acute caffeine administration influences risk-taking behavior in a dose-dependent manner. Participants were pre- (ages 8-9) and post-pubertal (ages 15-17) children who visited the laboratory three times and consumed a beverage containing 0, 1, or 2 mg/kg of caffeine. Thirty minutes later, participants completed the balloon analogue risk task (BART), the Iowa gambling task (IGT), and a delay discounting task. The number of balloons exploded on the BART task was significantly increased after 2 mg/kg of caffeine in moderate caffeine consumers, but was decreased after 2 mg/kg of caffeine in high caffeine consumers. There were no main effects of caffeine dose on the delay discounting task or on the IGT. Post-pubertal participants showed reduced delay discounting compared with pre-pubertal participants. Finally, average daily caffeine use was significantly, positively correlated with scores on a risk-taking questionnaire. These data suggest that caffeine dose-dependently influences decision making and risk taking. More research is needed to determine the mechanism of this difference as well as the extent to which sex and pubertal phase influence these relationships.

Comparison and validation of statistical methods for predicting power outage durations in the event of hurricanes.

PubMed

Nateghi, Roshanak; Guikema, Seth D; Quiring, Steven M

2011-12-01

This article compares statistical methods for modeling power outage durations during hurricanes and examines the predictive accuracy of these methods. Being able to make accurate predictions of power outage durations is valuable because the information can be used by utility companies to plan their restoration efforts more efficiently. This information can also help inform customers and public agencies of the expected outage times, enabling better collective response planning, and coordination of restoration efforts for other critical infrastructures that depend on electricity. In the long run, outage duration estimates for future storm scenarios may help utilities and public agencies better allocate risk management resources to balance the disruption from hurricanes with the cost of hardening power systems. We compare the out-of-sample predictive accuracy of five distinct statistical models for estimating power outage duration times caused by Hurricane Ivan in 2004. The methods compared include both regression models (accelerated failure time (AFT) and Cox proportional hazard models (Cox PH)) and data mining techniques (regression trees, Bayesian additive regression trees (BART), and multivariate additive regression splines). We then validate our models against two other hurricanes. Our results indicate that BART yields the best prediction accuracy and that it is possible to predict outage durations with reasonable accuracy. © 2011 Society for Risk Analysis.

When performance and risk taking are related: Working for rewards is related to risk taking when the value of rewards is presented briefly.

PubMed

Veling, Harm; Bijleveld, Erik

2015-12-01

Valuable monetary rewards can boost human performance on various effortful tasks even when the value of the rewards is presented too briefly to allow for strategic decision making. However, the mechanism by which briefly-presented reward information influences performance has remained unclear. One possibility is that performance after briefly-presented reward information is primarily boosted via activation of the dopamine reward system, whereas performance after very visible reward information is driven more by strategic processes. To examine this hypothesis, we first presented participants with a task in which they could earn rewards of relatively low (1 cent) or high (10 cents) value, and the value information was presented either briefly (17 ms) or for an extended duration (300 ms). Furthermore, responsiveness of the dopamine system was indirectly estimated with a measure of risk taking, the Balloon Analogue Risk Task (BART). Results showed that performance after high- compared to low-value rewards was indeed related to the BART scores only when reward information was presented briefly. These results are suggestive of the possibility that brief presentation of reward information boosts performance directly via activating the dopamine system, whereas extended presentation of reward information leads to more strategic reward-driven behavior. Copyright © 2015 Elsevier Inc. All rights reserved.

Haemoglobinopathies in Southeast Asia

PubMed Central

Fucharoen, Suthat; Winichagoon, Pranee

2011-01-01

In Southeast Asia α-thalassaemia, β-thalassaemia, haemoglobin (Hb) E and Hb Constant Spring (CS) are prevalent. The abnormal genes in different combinations lead to over 60 different thalassaemia syndromes, making Southeast Asia the locality with the most complex thalassaemia genotypes. The four major thalassaemic diseases are Hb Bart's hydrops fetalis (homozygous α-thalassaemia 1), homozygous β-thalassaemia, β-thalassaemia/Hb E and Hb H diseases. α-Thalassaemia, most often, occurs from gene deletions whereas point mutations and small deletions or insertions in the β-globin gene sequence are the major molecular defects responsible for most β-thalassaemias. Clinical manifestations of α-thalassaemia range from asymptomatic cases with normal findings to the totally lethal Hb Bart's hydrops fetalis syndrome. Homozygosity of β-thalassaemia results in a severe thalassaemic disease while the patients with compound heterozygosity, β-thalassaemia/Hb E, present variable severity of anaemia, and some can be as severe as homozygous β-thalassaemia. Concomitant inheritance of α-thalassaemia and increased production of Hb F are responsible for mild clinical phenotypes in some patients. However, there are still some unknown factors that can modulate disease severity in both α- and β-thalassaemias. Therefore, it is possible to set a strategy for prevention and control of thalassaemia, which includes population screening for heterozygotes, genetic counselling and foetal diagnosis with selective abortion of affected pregnancies. PMID:22089614

Ensemble of trees approaches to risk adjustment for evaluating a hospital's performance.

PubMed

Liu, Yang; Traskin, Mikhail; Lorch, Scott A; George, Edward I; Small, Dylan

2015-03-01

A commonly used method for evaluating a hospital's performance on an outcome is to compare the hospital's observed outcome rate to the hospital's expected outcome rate given its patient (case) mix and service. The process of calculating the hospital's expected outcome rate given its patient mix and service is called risk adjustment (Iezzoni 1997). Risk adjustment is critical for accurately evaluating and comparing hospitals' performances since we would not want to unfairly penalize a hospital just because it treats sicker patients. The key to risk adjustment is accurately estimating the probability of an Outcome given patient characteristics. For cases with binary outcomes, the method that is commonly used in risk adjustment is logistic regression. In this paper, we consider ensemble of trees methods as alternatives for risk adjustment, including random forests and Bayesian additive regression trees (BART). Both random forests and BART are modern machine learning methods that have been shown recently to have excellent performance for prediction of outcomes in many settings. We apply these methods to carry out risk adjustment for the performance of neonatal intensive care units (NICU). We show that these ensemble of trees methods outperform logistic regression in predicting mortality among babies treated in NICU, and provide a superior method of risk adjustment compared to logistic regression.

Dayside atmospheric structure of HD209458b from Spitzer eclipses

NASA Astrophysics Data System (ADS)

Reinhard, Matthew; Harrington, Joseph; Challener, Ryan; Cubillos, Patricio; Blecic, Jasmina

2017-10-01

HD209458b is a hot Jupiter with a radius of 1.26 ± 0.08 Jupiter radii (Richardson et al, 2006) and a mass of 0.64 ± 0.09 Jupiter masses (Snellen et al, 2010). The planet orbits a G0 type star with an orbital period of 3.52472 ± 2.81699e-05 days, and a relatively low eccentricity of 0.0082 +0.0078/-0.0082 (Wang and Ford 2013). We report the analysis of observations of HD209458b during eclipse, taken in the 3.6 and 4.5 micron channels by the Spitzer Space Telescope's Infrared Array Camera (Program 90186). We produce a photometric light curve of the eclipses in both channels, using our Photometry for Orbits Eclipses and Transits (POET) code, and calculate the brightness temperatures and eclipse depths. We also present best estimates of the atmospheric parameters of HD209458b using our Bayesian Atmospheric Radiative Transfer (BART) code. These are some preliminary results of what will be an analysis of all available Spitzer data for HD209458b. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

KSC-2009-3841

NASA Image and Video Library

2009-06-25

CAPE CANAVERAL, Fla. – A prelaunch news conference on the Geostationary Operational Environmental Satellite-O mission is held in NASA's Kennedy Space Center press site auditorium. From left, the participants are George H. Diller, moderator, Media Services, Kennedy Space Center; Gary Davis, director, Office of Systems Development, NOAA Satellite and Information Service, Suitland, Md.; Kris Walsh, Commercial Programs manager, United Launch Alliance, Houston; Kevin Reyes, director, Business Development, Boeing Launch Services; Andre Dress, GOES-O deputy project manager, Goddard Space Flight Center; Charlie Maloney, GOES-O program manager, Boeing Space and Intelligence Systems, Seal Beach, Calif.; Bart Hagemeyer, meteorologist in charge, NOAA National Weather Service forecast office, Melbourne, Fla.; and Joel Tumbiolo, Delta IV launch weather officer, 45th Weather Squadron, Cape Canaveral Air Force Station. The GOES-O satellite is targeted to launch June 26. The latest Geostationary Operational Environmental Satellite, GOES-O was developed by NASA for the National Oceanic and Atmospheric Administration, or NOAA. Each of the GOES satellites continuously provides observations of 60 percent of the Earth including the continental United States, providing weather monitoring and forecast operations as well as a continuous and reliable stream of environmental information and severe weather warnings. Once in orbit, GOES-O will be designated GOES-14, and NASA will provide on-orbit checkout and then transfer operational responsibility to NOAA. Photo credit: NASA/Jim Grossmann

K-12 Science and Math Education across the Federal Agencies. Hearing before the Committee on Science, U.S. House of Representatives, One Hundred Ninth Congress, Second Session (March 30, 2006). Serial Number 109-43

ERIC Educational Resources Information Center

US House of Representatives, 2006

2006-01-01

This document records testimony from a hearing held to examine how federal agencies can improve their individual and collective efforts to strengthen K-12 science and math education. Presenters and witnesses included: Representative Sherwood L. Boehlert, Chairman, Committee on Science, U.S. House of Representatives; Representative Bart Gordon,…

["Anxiety glistens on our brows". Dream reports in literary works on the horrors of ghettos and concentration camps].

PubMed

Klein, J

1991-06-01

Dream reports occupy a special place in literature about confinement in concentration camps and ghettos (Robert Antelme, Charlotte Delbo, Anna Langfus, André Schwarz-Bart). They are central elements in the narrative that relate the anxiety of those threatened with destruction more faithfully than any realistic account could. They disrupt the chronological linearity and rationality and represent in images horror beyond memory or description.

Testing technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-10-01

This bulletin from Sandia National Laboratories presents current research highlights in testing technology. Ion microscopy offers new nondestructive testing technique that detects high resolution invisible defects. An inexpensive thin-film gauge checks detonators on centrifuge. Laser trackers ride the range and track helicopters at low-level flights that could not be detected by radar. Radiation transport software predicts electron/photon effects via cascade simulation. Acoustic research in noise abatement will lead to quieter travelling for Bay Area Rapid Transport (BART) commuters.

Resourceful Computing in Unstructured Environments

DTIC Science & Technology

1991-07-31

D.J. Ehrlich, K.R. Udayakumar and L.E. Cross. "Piezoelectric Micromotors for Microrobots." Proceedings of the 1990 Ultrasonics Symposium, Honolulu...HI, Dec. 4-7, 1990. Flynn, A.M., L.S. Tavrow, S.F. Bart, R.A. Brooks, D.J. Ehrlich, K.R. Udayakumar and L.E. Cross. "Piezoelectric Micromotors for...Ehrlich. "Ferroelectric Thin Films for Ultrasonic Micromotors ." Proceedings of the Micro Electro Mechanical Systems Conference, Nara, JAPAN. January 30

Evaluation of HRV Biofeedback as a Resilience Building Reserve Component

DTIC Science & Technology

2017-08-01

Inventions, patent applications, and/or licenses Nothing to report  Other Products  Study recruitment/announcement video  Mobile app for...International Award Amount: $1,833,144 Study / Product Aim(s) 1. Develop and test the PHIT platform for use with the BART protocol. 2. Examine...STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT The specific aims of this study are to (1) develop a

A Newly Designed Mobile-Based Computerized Cognitive Addiction Therapy App for the Improvement of Cognition Impairments and Risk Decision Making in Methamphetamine Use Disorder: Randomized Controlled Trial.

PubMed

Zhu, Youwei; Jiang, Haifeng; Su, Hang; Zhong, Na; Li, Runji; Li, Xiaotong; Chen, Tianzhen; Tan, Haoye; Du, Jiang; Xu, Ding; Yan, Huan; Xu, Dawen; Zhao, Min

2018-06-20

Cognitive rehabilitation therapy has been found to improve cognitive deficits and impulse control problems in methamphetamine use disorder (MUD). However, there is limited research regarding this therapy's feasibility when using mobile-based health technologies in supporting recovery from MUD in China. The main aim of this study was to test whether 4 weeks of a newly designed computerized cognitive addiction therapy (CCAT) app can improve cognitive impairments, eliminate drug-related attention bias, and attenuate risk decision-making behaviors in participants with MUD. Forty MUD participants were assigned randomly to either the CCAT group (n=20), who received 4 weeks of CCAT plus regular detoxification treatment as usual, or the control group (n=20), who only received the regular detoxification treatment as usual, in drug rehabilitation centers in Shanghai. The CCAT was designed by combine methamphetamine use-related picture stimuli with cognitive training with the aim of improving cognitive function and eliminating drug-related attention bias. The CogState Battery, Delay Discounting Task (DDT), Iowa Gambling Task (IGT), and Balloon Analog Risk Task (BART) were administered face-to-face to all participants before and after CCAT interventions. Forty male patients were recruited. The mean age was 32.70 (SD 5.27) years in the CCAT group and mean 35.05 (SD 8.02) years in the control group. Compared to the control group, CCAT improved working memory in the CCAT group (P=.01). Group×time interactions were observed among DDT, IGT, and BART tasks, with rates of discounting delayed rewards, IGT, and BART scores (P<.001) being reduced among those who received CCAT, whereas no changes were found in the control group. The newly designed CCAT can help to improve cognitive impairment and impulsive control in MUD. Further study is needed to understand the underlying brain mechanisms of the cognitive therapy. ClinicalTrials.gov NCT03318081; https://clinicaltrials.gov/ct2/show/NCT03318081 (Archived by WebCite at https://clinicaltrials.gov/ct2/show/NCT03318081). ©Youwei Zhu, Haifeng Jiang, Hang Su, Na Zhong, Runji Li, Xiaotong Li, Tianzhen Chen, Haoye Tan, Jiang Du, Ding Xu, Huan Yan, Dawen Xu, Min Zhao. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 20.06.2018.

Measurement of the t t ¯ production cross-section using eμ events with b-tagged jets in pp collisions at s = 13 TeV with the ATLAS detector

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aaboud, M.; Aad, G.; Abbott, B.

This paper describes a measurement of the inclusive top quark pair production cross-section (σ tmore » $$\\bar{t}$$) with a data sample of 3.2 fb -1 of proton–proton collisions at a centre-of-mass energy of √s = 13 TeV, collected in 2015 by the ATLAS detector at the LHC.« less

Piezoelectric and Electrostrictive Materials for Transducers Applications. Volume 4

DTIC Science & Technology

1992-01-31

Micromotors ." IEEE. 109-113 (1991). 41. Anita M. Flynn. Lee S. Tavrow. Stephen F. Bart. Rodney A. Brooks. Daniel J. Ehrlich. K. R. Udayakumar and L. Eric...Cross. "Piezoelectric Micromotors for Microrobots." J. Microelectromechanical Systems 1 (1) 47-50 (1992). 4 APPENDIX 35 A STUDY OF YI Ba2 Cti30 7.y...to produce miniature pumps. valves. microsensors and micromotors . This paper reports on the fabrication of thin films that are capable of producing

Command History for 1989.

DTIC Science & Technology

1990-09-01

13 Bart Kuhn, GM-14 Samantha K. Maddox , GS-04 Mike Nakada, GM- 13 John Wolfe, GM-14 Reynaldo I. Monzon, GS- 12 Jose G. Suarez, GS- 11 19 Product...1410-09 GS-334-09 Janice Whiting Procurement Clerk Code 21 GS-1106-05 Separations Samantha Maddox Hoa T. Lu Supply Clerk Computer Specialist Code 21...Jennifer Thorp Royal S. Magnus Student Aide Personnel Research Psychologist Code 23 Code 12 GW-322-03 GS-180-11 Linda L. Turnmire Yvonne S. Baker Computer

Prediction of Transition States and Thermochemistry for Combustion Reactions.

DTIC Science & Technology

1984-04-07

ARO have yet received their degrees, although Mr. Sohrab Zarrabian and Mr. David Magers have been working on ARO projects. Postdoctoral students who...Schaefer (141), using SD-CI techniques and David - son’s correction to estimate the effects of quadruple excitations, deter- mined the barriers and...T.. Purvis. G. D., Bart- land: Reidel; Langhoff, S. R.. David - lett. R. J. 1978. J. Chem. Phys. 69: son, E. R. 1974. Int. J. Quantum 5386 Chem. 8:61

Integrating frequency and magnitude information in decision-making in schizophrenia: An account of patient performance on the Iowa Gambling Task.

PubMed

Brown, Elliot C; Hack, Samantha M; Gold, James M; Carpenter, William T; Fischer, Bernard A; Prentice, Kristen P; Waltz, James A

2015-01-01

The Iowa Gambling Task (IGT; Bechara et al., 1994) has frequently been used to assess risky decision making in clinical populations, including patients with schizophrenia (SZ). Poor performance on the IGT is often attributed to reduced sensitivity to punishment, which contrasts with recent findings from reinforcement learning studies in schizophrenia. In order to investigate possible sources of IGT performance deficits in SZ patients, we combined data from the IGT from 59 SZ patients and 43 demographically-matched controls with data from the Balloon Analog Risk Task (BART) in the same participants. Our analyses sought to specifically uncover the role of punishment sensitivity and delineate the capacity to integrate frequency and magnitude information in decision-making under risk. Although SZ patients, on average, made more choices from disadvantageous decks than controls did on the IGT, they avoided decks with frequent punishments at a rate similar to controls. Patients also exhibited excessive loss-avoidance behavior on the BART. We argue that, rather than stemming from reduced sensitivity to negative consequences, performance deficits on the IGT in SZ patients are more likely the result of a reinforcement learning deficit, specifically involving the integration of frequencies and magnitudes of rewards and punishments in the trial-by-trial estimation of expected value. Copyright © 2015 Elsevier Ltd. All rights reserved.

Smoked Cannabis' Psychomotor and Neurocognitive Effects in Occasional and Frequent Smokers

PubMed Central

Desrosiers, Nathalie A.; Ramaekers, Johannes G.; Chauchard, Emeline; Gorelick, David A.; Huestis, Marilyn A.

2015-01-01

Δ9-Tetrahydrocannabinol (THC), the primary psychoactive constituent in cannabis, impairs psychomotor performance, cognition and driving ability; thus, driving under the influence of cannabis is a public safety concern. We documented cannabis' psychomotor, neurocognitive, subjective and physiological effects in occasional and frequent smokers to investigate potential differences between these smokers. Fourteen frequent (≥4x/week) and 11 occasional (<2x/week) cannabis smokers entered a secure research unit ∼19 h prior to smoking one 6.8% THC cigarette. Cognitive and psychomotor performance was evaluated with the critical tracking (CTT), divided attention (DAT), n-back (working memory) and Balloon Analog Risk (BART) (risk-taking) tasks at −1.75, 1.5, 3.5, 5.5 and 22.5 h after starting smoking. GLM (General Linear Model) repeated measures ANOVA was utilized to compare scores. Occasional smokers had significantly more difficulty compensating for CTT tracking error compared with frequent smokers 1.5 h after smoking. Divided attention performance declined significantly especially in occasional smokers, with session × group effects for tracking error, hits, false alarms and reaction time. Cannabis smoking did not elicit session × group effects on the n-back or BART. Controlled cannabis smoking impaired psychomotor function, more so in occasional smokers, suggesting some tolerance to psychomotor impairment in frequent users. These data have implications for cannabis-associated impairment in driving under the influence of cannabis cases. PMID:25745105

THE RELATIONSHIP BETWEEN IMPULSIVITY, -TAKING PROPENSITY AND NICOTINE DEPENDENCE AMONG OLDER ADOLESCENT SMOKERS

PubMed Central

Ryan, Katherine K.; MacKillop, James; Carpenter, Matthew J.

2012-01-01

Impulsivity and risk-taking propensity are neurobehavioral traits that reliably distinguish between smoking and non-smoking adults. However, how these traits relate to smoking quantity and nicotine dependence among older adolescent smokers is unclear. The current study examined impulsivity and risk-taking propensity in relation to smoking behavior and nicotine dependence among current older adolescent smokers (age 16–20 years; N = 107). Participants completed the Barratt Impulsiveness Scale–11 (BIS-11), the Balloon Analogue Risk Task (BART), and self-report measures of smoking behavior and nicotine dependence. Results indicated a significant positive relationship between nicotine dependence and the Attention subscale (β =.20, t = 2.07, p <.05) and the Non-planning subscale (β =.19, t=1.92, p<.06) of the BIS-11. Contrary to expectation, the results also indicated a significant negative relationship between performance on the BART and nicotine dependence (β = −.19, t=−2.18, p <.05), such that greater risk-taking propensity was associated with less dependence. These data suggest that impulsivity and risk-taking propensity are related to older adolescent smoking but are separable traits with distinguishable associations to nicotine dependence among adolescents. These findings support the notion that impulsivity is related to heightened nicotine dependence, but suggest the relationship between risk-taking propensity and nicotine dependence is more ambiguous and warrants further investigation. PMID:23006247

Regulatory Mode and Risk-Taking: The Mediating Role of Anticipated Regret

PubMed Central

Panno, Angelo; Lauriola, Marco; Pierro, Antonio

2015-01-01

We propose that decision maker’s regulatory mode affects risk-taking through anticipated regret. In the Study 1 either a locomotion or an assessment orientation were experimentally induced, and in the Studies 2 and 3 these different orientations were assessed as chronic individual differences. To assess risk-taking we used two behavioral measures of risk: BART and hot-CCT. The results show that experimentally induced assessment orientation–compared to locomotion–leads to decreased risk-taking through increased anticipated regret (Study 1). People chronically predisposed to be in the assessment state take less risk through increased anticipated regret (Study 2 and Study 3). Study 2 results also show a marginally non-significant indirect effect of chronic locomotion mode on BART through anticipated regret. Differently, Study 3 shows that people chronically predisposed to be in the locomotion state take greater risk through decreased anticipated regret, when play a dynamic risk task triggering stronger emotional arousal. Through all three studies, the average effect size for the relationship of assessment with anticipated regret was in the moderate-large range, whereas for risk-taking was in the moderate range. The average effect size for the relationship of locomotion with anticipated regret was in the moderate range, whereas for risk-taking was in the small-moderate range. These results increase our understanding of human behavior under conditions of risk obtaining novel insights into regulatory mode theory and decision science. PMID:26580960

Blunted feedback processing during risk-taking in adolescents with features of problematic Internet use.

PubMed

Yau, Yvonne H C; Potenza, Marc N; Mayes, Linda C; Crowley, Michael J

2015-06-01

While the conceptualization of problematic Internet use (PIU) as a "behavioral addiction" resembling substance-use disorders is debated, the neurobiological underpinnings of PIU remain understudied. This study examined whether adolescents displaying features of PIU (at-risk PIU; ARPIU) are more impulsive and exhibit blunted responding in the neural mechanisms underlying feedback processing and outcome evaluation during risk-taking. Event-related potentials (ERPs) elicited by positive (i.e. reward) and negative (i.e. loss) feedback were recorded during performance on a modified version of the Balloon Analogue Risk Task (BART) among ARPIU (n=39) and non-ARPIU subjects (n=27). Compared to non-ARPIU, ARPIU adolescents displayed higher levels of urgency and lack of perseverance on the UPPS Impulsive Behavior Scale. Although no between-group difference in BART performance was observed, ERPs demonstrated overall decreased sensitivity to feedback in ARPIU compared to non-ARPIU adolescents, as indexed by blunted feedback-related negativity (FRN) and P300 amplitudes to both negative and positive feedback. The present study provides evidence for feedback processing during risk-taking as a neural correlate of ARPIU. Given recent concerns regarding the growing prevalence of PIU as a health concern, future work should examine the extent to which feedback processing may represent a risk factor for PIU, a consequence of PIU, or possibly both. Copyright © 2015 Elsevier Ltd. All rights reserved.

Coordinated train control and energy management control strategies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gordon, S.P.; Lehrer, D.G.

1998-05-01

The Bay Area Rapid Transit (BART) system, in collaboration with Hughes Aircraft Company and Harmon Industries, as in the process of developing an Advanced Automatic Train Control (AATC) system to replace the current fixed-block automatic system. In the long run, the AATC system is expected to not only allow for safe short headway operation, but also to facilitate coordinated train control and energy management. This new system will employ spread spectrum radios, installed onboard trains, at wayside locations, and at control stations, to determine train locations and reliably transfer control information. Sandia National Laboratories has worked cooperatively with BART tomore » develop a simulator of the train control and the power consumption of the AATC system. The authors are now in the process of developing enhanced train control algorithms to supplement the safety critical controller in order to smooth out train trajectories through coordinated control of multiple trains, and to reduce energy consumption and power infrastructure requirements. The control algorithms so far considered include (1) reducing peak power consumption to avoid voltage sags, especially during an outage or while clearing a backup, (2) rapid and smooth recovery from a backup, (3) avoiding oscillations due to train interference, (4) limiting needle peaks in power demand at substations to some specified level, (5) coasting, and (6) coordinating train movement, e.g., starts/stops and hills.« less

Integrating frequency and magnitude information in decision-making in schizophrenia: An account of patient performance on the Iowa Gambling Task

PubMed Central

Brown, Elliot C.; Hack, Samantha M.; Gold, James M.; Carpenter, William T.; Fischer, Bernard A.; Prentice, Kristen P.; Waltz, James A.

2015-01-01

Background The Iowa Gambling Task (IGT; Bechara, Damasio, Damasio, & Anderson, 1994) has frequently been used to assess risky decision making in clinical populations, including patients with schizophrenia (SZ). Poor performance on the IGT is often attributed to reduced sensitivity to punishment, which contrasts with recent findings from reinforcement learning studies in schizophrenia. Methods In order to investigate possible sources of IGT performance deficits in SZ patients, we combined data from the IGT from 59 SZ patients and 43 demographically-matched controls with data from the Balloon Analog Risk Task (BART) in the same participants. Our analyses sought to specifically uncover the role of punishment sensitivity and delineate the capacity to integrate frequency and magnitude information in decision-making under risk. Results Although SZ patients, on average, made more choices from disadvantageous decks than controls did on the IGT, they avoided decks with frequent punishments at a rate similar to controls. Patients also exhibited excessive loss-avoidance behavior on the BART. Conclusions We argue that, rather than stemming from reduced sensitivity to negative consequences, performance deficits on the IGT in SZ patients are more likely the result of a reinforcement learning deficit, specifically involving the integration of frequencies and magnitudes of rewards and punishments in the trial-by-trial estimation of expected value. PMID:25959618

Gunslingers, poker players, and chickens 2: Decision-making under physical performance pressure in subelite athletes.

PubMed

Parkin, Beth L; Walsh, Vincent

2017-01-01

Having investigated the influence of acute physical exhaustion on decision-making in world-class elite athletes in Parkin et al. (2017), here a similar method is applied to subelite athletes. These subelite athletes were enrolled on a Team GB talent development program and were undergoing training for possible Olympic competition in 4-8 years. They differ from elite athletes examined previously according to expertise and age. While considered elite (Swann et al., 2015), the subelite athletes had approximately 8 years fewer sporting experience and were yet to obtain sustained success on the international stage. Additionally, the average age of the subelite sample is 20 years; thus, they are still undergoing the behavioral, cognitive, and neuronal changes that occur during the transition from late adolescence to young adulthood (Blakemore and Robbins, 2012). Previous work has used broad definitions of elite status in sport, and as such overlooked different categories within the spectrum of elite athletes (Swann et al., 2015). Therefore it is important to consider subelite athletes as a discrete point on the developmental trajectory of elite sporting expertise. This work aims to investigate the influence of physical pressure on key indicators of decision-making in subelite athletes. It forms part of a wider project examining decision-making across different stages of the developmental trajectory in elite sport. In doing so, it aims to examine how to apply and develop psychological insights useful to an elite sporting environment. 32 subelite athletes (18 males, mean age: 20 years) participated in the study. Performance across three categories of decision-making was assessed under conditions of low and high physical pressure. Decision-making under risk was measured with performance of the Cambridge Gambling Task (CGT; Rogers et al., 1999), decision-making under uncertainty with the Balloon Analogue Risk Task (BART; Lejuez et al., 2002), and fast reactive responses and inhibition via the Stop Signal Reaction Time Task (SSRT; Logan, 1994). Physical exhaustion was induced via intervals of maximal exertion exercise on a wattbike. Under pressure subelite athletes showed increased risk taking for both decisions where probability outcomes were explicit (on the CGT), and those where probability outcomes were unknown (on the BART). Despite making quicker decisions under pressure, with fewer errors, on the CGT, subelite athletes showed a reduced ability to optimally adjust betting behavior according to reward and loss contingencies. Fast reactive responses to perceptual stimuli and response inhibition did not change as a result of physical pressure. Individual responses to pressure showed a negative correlation in that a decrease in reaction times on the SSRT Task under pressure was associated with an increase in risk taking on the BART. When assessing the applicability of results based on group averages to individual athletes, 17% of the sample showed an "average" response (within 1 SD of the mean) to pressure across all three decision-making tasks. Indicators of decision-making in a sample of subelite athletes are influenced by physical pressure, with a shift toward increased indiscriminate risk taking. The influence that physical pressure has on decision-making was different to that observed in world-class elite athletes; this highlights the importance of distinguishing between athletes at the elite level (Swann et al., 2015). The application of this work to a novel subgroup of elite athletes, including the implementation of a decision-making taxonomy, is discussed. © 2017 Elsevier B.V. All rights reserved.

Atmospheric Retrievals of HAT-P-16b and WASP-11b/HAT-P-10b

NASA Astrophysics Data System (ADS)

McIntyre, Kathleen; Harrington, Joseph; Challener, Ryan; Lenius, Maria; Hartman, Joel D.; Bakos, Gaspar A.; Blecic, Jasmina; Cubillos, Patricio E.; Cameron, Andrew

2018-01-01

We report Bayesian atmospheric retrievals performed on the exoplanets HAT-P-16b and WASP-11b/HAT-P-10b. HAT-P-16b is a hot (equilibrium temperature 1626 ± 40 K, assuming zero Bond albedo and efficient energy redistribution), 4.19 ± 0.09 Jupiter-mass exoplanet orbiting an F8 star every 2.775960 ± 0.000003 days (Buchhave et al 2010). WASP-11b/HAT-P-10b is a cooler (1020 ± 17 K), 0.487 ± 0.018 Jupiter-mass exoplanet orbiting a K3 star every 3.7224747 ± 0.0000065 days (Bakos et al. 2009, co-discovered by West et al. 2008). We observed secondary eclipses of both planets using the 3.6 μm and 4.5 μm channels of the Spitzer Space Telescope's Infrared Array Camera (program ID 60003). We applied our Photometry for Orbits, Eclipses, and Transits (POET) code to produce normalized eclipse light curves, and our Bayesian Atmospheric Radiative Transfer (BART) code to constrain the temperature-pressure profiles and atmospheric molecular abundances of the two planets. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

Bart's familiar quotations: the enduring biological wisdom of George A. Bartholomew.

PubMed

Huey, Raymond B; Bennett, Albert F

2008-01-01

George A. Bartholomew was one of the most influential organismal biologists of the twentieth century. His insights and research were fundamental to the establishment and growth of physiological ecology and evolutionary physiology. In the process of fostering that area of science, he created a body of literature that is striking in the clarity of its thought and presentation. Here we present some of his most insightful and important quotations, group them thematically, and comment on their original context and their continuing relevance.

BaRT Manual Version 3.0

DTIC Science & Technology

1991-02-14

collectio of ifnformation is eitirmate" to average Ihoar der fesporse. inciudng the time for reviwing instructions, searchi’ng estung data sources...visible field of the buffer. <Cntl>-n -- next visible field of the buffer. <Cntl>- k -- kill from point to end of buffer. <Cntl>-y -- yank from kill ring...and a button. Position the mouse on the field in front of the Name. A box will highlight this field. Click on this field. Press <cntr> k to remove the

Workshop on Scientific Analysis and Policy in Network Security

DTIC Science & Technology

2010-09-10

IBBT Dcpt. Electrical Engineering-ESAT/COSlC. Kasteelpark Arenberg 10 Bus 2446, B-3001 Leuven. Belgium bart.preneelflesat.kuleuven.be Abstract. This...Bouissou1,3 1 Electricity de France R&D, 1 avenue du General de Gaulle, 92141 Clamart, France 2 Institut Telecom, Telecom ParisTech, 46 rue Barrault...for any x G Aj1; /, !,_0(x) is a probability distribution on AQ, such that if x G S{i then £jeS, (/’.^(.OXj) = L illul if x e Dii > then £j

Airman Classification Batteries from 1948 to 1975: A Review and Evaluation

DTIC Science & Technology

1975-12-01

1975 6 PERFORMING ORG REPORT NUMBER 7. AUTI4ORWe S. CONTRACT OR GRANT NUMBER(S) Joseph L. Weeks Cecil J. Mullins Bart M. %’itola 9 PERF’rRMING...norms were developed by the equi-percentile method based on a random sample of 3,936 basic trainees (Vitola, Massey, & Wilbourn , 1971). The TALENT test...661 996. Lackland AFB. Tex.: Personnel Research Laboratory, Aerospace Medical Division, August 1967. Vitola, B.M., Massey, 1.11., & Wilbourn , J .M

Variations in Particulate Matter (PM 2.5) Concentration Levels at a Major Bay Area Rapid Transit (BART) Railway Station

NASA Astrophysics Data System (ADS)

Luong, K.; Sethy, D.; Yu, I.; Hernandez, N.; Fang, K.; Zhang, W.; Li, J.; Hoang, R.; Munui, K. N.; Sot, R.; Rodriguez, V. A.; Chiu, D.; Sankar, R.; Bonzo, R.

2016-12-01

Previous research has identified high levels of PM 2.5 in Embarcadero Station within the Bay Area Rapid Transit (BART) system. The current study examined PM 2.5 levels within Embarcadero Station to confirm previous results, as well as to determine exposure with respect to a location on the platform. Data collected confirmed the effectiveness of using DustTrak devices to collect elevated PM data. Our research established a model for PM 2.5 levels in a stationary location on the Embarcadero platform over a span of 10 minutes.This allowed us to compare the east and west ends of Embarcadero station platform for levels of PM2.5. A significantly higher level of PM2.5 was found on the east end of the platform, supporting last year's study. This methodology builds on last year's research to show a sustained high level of PM 2.5 on either end of the platform, with a significant elevated levels on the east end. Collecting data from a stationary location provided insight on exposure for an individual waiting in one spot rather than walking along the platform prior to train arrival. While the level of PM 2.5 varied over time, the average PM 2.5 over the 10 minute period were still at unhealthy levels. Our research suggests that location of an individual on the platform does affect their exposure level and therefore recommendations can be made for individuals with higher risk.

Cued to Act on Impulse: More Impulsive Choice and Risky Decision Making by Women Susceptible to Overeating after Exposure to Food Stimuli.

PubMed

Yeomans, Martin R; Brace, Aaron

2015-01-01

There is increasing evidence that individual differences in tendency to overeat relate to impulsivity, possibly by increasing reactivity to food-related cues in the environment. This study tested whether acute exposure to food cues enhanced impulsive and risky responses in women classified on tendency to overeat, indexed by scores on the three factor eating questionnaire disinhibition (TFEQ-D), restraint (TFEQ-R) and hunger scales. Ninety six healthy women completed two measures of impulsive responding (delayed discounting, DDT and a Go No-Go, GNG, task) and a measure of risky decision making (the balloon analogue risk task, BART) as well as questionnaire measures of impulsive behaviour either after looking at a series of pictures of food or visually matched controls. Impulsivity (DDT) and risk-taking (BART) were both positively associated with TFEQ-D scores, but in both cases this effect was exacerbated by prior exposure to food cues. No effects of restraint were found. TFEQ-D scores were also related to more commission errors on the GNG, while restrained women were slower on the GNG, but neither effect was modified by cue exposure. Overall these data suggest that exposure to food cues act to enhance general impulsive responding in women at risk of overeating and tentatively suggest an important interaction between tendency for impulsive decision making and food cues that may help explain a key underlying risk factor for overeating.

CISN ShakeAlert: Using early warnings for earthquakes in California

NASA Astrophysics Data System (ADS)

Vinci, M.; Hellweg, M.; Jones, L. M.; Khainovski, O.; Schwartz, K.; Lehrer, D.; Allen, R. M.; Neuhauser, D. S.

2009-12-01

Educated users who have developed response plans and procedures are just as important for an earthquake early warning (EEW) system as are the algorithms and computers that process the data and produce the warnings. In Japan, for example, the implementation of the EEW system which now provides advanced alerts of ground shaking included intense outreach efforts to both institutional and individual recipients. Alerts are now used in automatic control systems that stop trains, place sensitive equipment in safe mode and isolate hazards while the public takes cover. In California, the California Integrated Seismic Network (CISN) is now developing and implementing components of a prototype system for EEW, ShakeAlert. As this processing system is developed, we invite a suite of perspective users from critical industries and institutions throughout California to partner with us in developing useful ShakeAlert products and procedures. At the same time, we will support their efforts to determine and implement appropriate responses to an early warning of earthquake shaking. As a first step, in a collaboration with BART, we have developed a basic system allowing BART’s operation center to receive realtime ground shaking information from more than 150 seismic stations operating in the San Francisco Bay Area. BART engineers are implementing a display system for this information. Later phases will include the development of improved response procedures utilizing this information. We plan to continue this collaboration to include more sophisticated information from the prototype CISN ShakeAlert system.

Cued to Act on Impulse: More Impulsive Choice and Risky Decision Making by Women Susceptible to Overeating after Exposure to Food Stimuli

PubMed Central

Yeomans, Martin R.; Brace, Aaron

2015-01-01

There is increasing evidence that individual differences in tendency to overeat relate to impulsivity, possibly by increasing reactivity to food-related cues in the environment. This study tested whether acute exposure to food cues enhanced impulsive and risky responses in women classified on tendency to overeat, indexed by scores on the three factor eating questionnaire disinhibition (TFEQ-D), restraint (TFEQ-R) and hunger scales. Ninety six healthy women completed two measures of impulsive responding (delayed discounting, DDT and a Go No-Go, GNG, task) and a measure of risky decision making (the balloon analogue risk task, BART) as well as questionnaire measures of impulsive behaviour either after looking at a series of pictures of food or visually matched controls. Impulsivity (DDT) and risk-taking (BART) were both positively associated with TFEQ-D scores, but in both cases this effect was exacerbated by prior exposure to food cues. No effects of restraint were found. TFEQ-D scores were also related to more commission errors on the GNG, while restrained women were slower on the GNG, but neither effect was modified by cue exposure. Overall these data suggest that exposure to food cues act to enhance general impulsive responding in women at risk of overeating and tentatively suggest an important interaction between tendency for impulsive decision making and food cues that may help explain a key underlying risk factor for overeating. PMID:26378459

Forecasted economic change and the self-fulfilling prophecy in economic decision-making

PubMed Central

2017-01-01

This study addresses the self-fulfilling prophecy effect, in the domain of economic decision-making. We present experimental data in support of the hypothesis that speculative forecasts of economic change can impact individuals’ economic decision behavior, prior to any realized changes. In a within-subjects experiment, participants (N = 40) played 180 trials in a Balloon Analogue Risk Talk (BART) in which they could make actual profit. Simple messages about possible (positive and negative) changes in outcome probabilities of future trials had significant effects on measures of risk taking (number of inflations) and actual profits in the game. These effects were enduring, even though no systematic changes in actual outcome probabilities took place following any of the messages. Risk taking also found to be reflected in reaction times revealing increasing reaction times with riskier decisions. Positive and negative economic forecasts affected reaction times slopes differently, with negative forecasts resulting in increased reaction time slopes as a function of risk. These findings suggest that forecasted positive or negative economic change can bias people’s mental model of the economy and reduce or stimulate risk taking. Possible implications for media-fulfilling prophecies in the domain of the economy are considered. PMID:28334031

Occurrence of the - -(SEA), - -(THAI) and - -(FIL) α-Thalassemia-1 Carriers from a 7-Year Study at Ramathibodi Hospital, Bangkok, Thailand.

PubMed

Pongjantharasatien, Kobkorn; Banyatsuppasin, Wansa; Pounsawat, Sonnarong; Jindadamrongwech, Sumalee

2016-08-01

α-Thalassemia (α-thal) is one of the most common genetic diseases in Thailand. Homozygosity of α-thal-1 (- -/- -) and compound heterozygosity of α-thal-1/α-thal-2 (- -/-α) leads to Hb Bart's (γ4) hydrops fetalis and Hb H (β4) disease, respectively. In order to better control and provide prevention of α-thal disease, the prevalence of α-thal-1 carriers and the types of genotypes in the Thai population should be known. A 7-year retrospective study, employing multiplex gap-polymerase chain reaction (gap-PCR) of 31,632 blood samples from Ramathibodi Hospital, Mahidol University, Bangkok, revealed an α-thal-1 carrier rate of 14.40% with the - -(SEA) (NG_000006.1: g.26264_45564del19301), - -(THAI) (NG_000006.1: g.10664_44164del33501) and - -(FIL) (NG_000006.1: g.11684_43534del31851) genotypes, constituting frequencies of 14.21, 0.18 and 0.01%, respectively. Although the - -(FIL) genotype is rare in the Thailand, its detection should be included in future α-thal screening programs.

Obituary: Raymond Edwin White Jr., 1933-2004

NASA Astrophysics Data System (ADS)

Liebert, James William

2004-12-01

Raymond E. White, Jr., died unexpectedly at his home, in the early morning hours of October 12, 2004. Death appears to have been caused by severe diabetic shock. He retired from the Department of Astronomy/Steward Observatory in July 1999 with the title of University Distinguished Professor, after serving on the faculty of this institution for over 35 years. He was born in Freeport, Illinois, on 6 May 1933, to Beatrice and Raymond E, Sr. -the latter being a career soldier in the US Army. Ray's early schooling took place in Illinois, New Jersey, Germany and Switzerland, following his father's assignments. He obtained a bachelors degree from the University of Illinois in 1955. Next Ray enlisted in the US Army, but quickly was enrolled in Officer Candidate School. He then served as lst Lt. in the US Army Corps of Engineers. Although military affairs remained a lifelong interest, and he was a member of the Company of Military Historians, Ray decided after three years to return to academia. He entered the astronomy PhD program at the University of Illinois in 1958. His PhD dissertation was supervised by Ivan R. King. Ray accepted a faculty position at the University of Arizona in 1964. First and foremost, Ray White was known at Arizona as an excellent teacher, revered by a large number of former students. When the astronomy major program was begun in 1967, Ray was one of three, original, major advisors. Over the next three decades, he was a leader at the University level in reforming the undergraduate program and courses. He was selected Outstanding University Faculty Member in April 1989 and he served as one of a handful of professors who are Faculty Fellows. These Fellows devote untold hundreds of hours as part-time residents at student dormitories, to give students a friendly face to address their problems. In 1995, Ray was among the first group of faculty to be recognized as University Distinguished Professors. In the year of his retirement, 1999, University President Manuel Pachecho recognized Ray's extensive contributions by asking him to serve as Master of Ceremonies at the University commencement. Ray White's research career was not as extensive as his teaching activities, but it was creative. His original specialty was globular star clusters and classes of variable stars within them. He made several catalogs of star clusters and associations, measured the exact centers, the axial ratios and the orientations of around 100 Galactic globular clusters. Certainly, Ray's greatest love in research, especially in later years, was archaeoastronomy. He studied the evidence for astronomical observations of the Sun, Moon and stars from the mound sites of the prehistoric Hohokam inhabitants of the Salt River Valley of Arizona. He was best known for his studies of the Inkaic people of the pre-Columbian, Peruvian Andes. Most of this research involved the grand Machu Picchu site, where he showed (with David Dearborn) that the central tower (the "Torreon") certainly had been used as an Observatory. They also discovered a separate, solstice observatory and named it Intimachay. Characteristically, Ray combined much of his archaeoastronomy research interests with the involvement of undergraduate students and adults through the Earthwatch program in field trips to Machu Picchu. With a Professor in the humanities who was also well known at the University of Arizona, Donna Swaim, Ray introduced a group of undergraduates in summer classes to several archaeoastronomy sites in such countries as Ireland and the British isles. Of course they also gave on-site lectures at art museums, and sites of historical and cultural interest. Like many astronomers, Ray was well traveled. He had sabbaticals at the University of Cambridge in 1980, and at the Dublin Institute of Advanced Study (Dunsink Observatory), Ireland, in 1996-97. The latter was funded by his winning a Fulbright Fellowship, which enabled him to further his studies of the Celtic astronomical traditions. Earlier in 1971-72, Ray served as Program Officer for Stars and Stellar Evolution in the Astronomy Section of the National Science Foundation. Ray was one of the three "originators" of "The Inspiration of Astronomical Phenomena" (INSAP) Conferences. These conferences provide scholarly discussions on the many and variegated cultural impacts of the perceptions about the day- and night-time sky, thus providing a forum for a broad sampling of artists, historians, philosophers, and scientists to get together, compare notes, and ask questions of one another. The INSAP Conferences have taken place near Castel Gandolfo Italy, on the island of Malta, near Palermo Italy, and at Oxford University in England. Ray's scholarship also was manifest in his activities as editor. For some years in the 1990s, he edited two astronomy journals, The Astronomy Quarterly and Vistas in Astronomy. Raymond E. White, Jr., is survived by his wife Ruby E. (nee Fisk), his high school sweetheart at Heidelberg High in Germany. Their children include Raymond E. White III (Professor of Physics and Astronomy at the University of Alabama, Tuscaloosa), Kathleen M. (White) Wade, and Kevin D. White. Ray was proud of two beautiful granddaughters, Charlotte R. Wade and Sarah E. Wade. Ray was proud of his early role with Steward Observatory Director Bart Bok in the commissioning of the "90-inch" reflector at the University of Arizona site on Kitt Peak in 1969. He built the direct camera, and was invited by his close friend Bok to share the "first light" of this telescope, now renamed the Bok 2.3-m telescope. When Professor Bok passed away, the astronomy magazine Sky & Telescope invited Ray to write an article which was entitled "Bart J. Bok (1906-83): Personal Memoir from a Grandson." (Bok mentored Ivan R. King, who was Ray's thesis advisor.) In his concluding remarks, Ray wrote, "The aspect of Bart J. Bok I will miss the most is his exuberance for the art of astronomy." We will also miss greatly this aspect of Raymond E. White, Jr.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fisher,D

Concerns about the long-term viability of SFS as the metadata store for HPSS have been increasing. A concern that Transarc may discontinue support for SFS motivates us to consider alternative means to store HPSS metadata. The obvious alternative is a commercial database. Commercial databases have the necessary characteristics for storage of HPSS metadata records. They are robust and scalable and can easily accommodate the volume of data that must be stored. They provide programming interfaces, transactional semantics and a full set of maintenance and performance enhancement tools. A team was organized within the HPSS project to study and recommend anmore » approach for the replacement of SFS. Members of the team are David Fisher, Jim Minton, Donna Mecozzi, Danny Cook, Bart Parliman and Lynn Jones. We examined several possible solutions to the problem of replacing SFS, and recommended on May 22, 2000, in a report to the HPSS Technical and Executive Committees, to change HPSS into a database application over either Oracle or DB2. We recommended either Oracle or DB2 on the basis of market share and technical suitability. Oracle and DB2 are dominant offerings in the market, and it is in the best interest of HPSS to use a major player's product. Both databases provide a suitable programming interface. Transaction management functions, support for multi-threaded clients and data manipulation languages (DML) are available. These findings were supported in meetings held with technical experts from both companies. In both cases, the evidence indicated that either database would provide the features needed to host HPSS.« less

THE RELATIONSHIP BETWEEN MEASURES OF IMPULSIVITY AND ALCOHOL MISUSE: AN INTEGRATIVE STRUCTURAL EQUATION MODELING APPROACH

PubMed Central

Courtney, Kelly E.; Arellano, Ryan; Barkley-Levenson, Emily; Gálvan, Adriana; Poldrack, Russell A.; MacKillop, James; Jentsch, J. David; Ray, Lara A.

2011-01-01

Background Higher levels of impulsivity have been implicated in the development of alcohol use disorders. Recent findings suggest that impulsivity is not a unitary construct, highlighted by the diverse ways in which the various measures of impulsivity relate to alcohol use outcomes. This study simultaneously tested the following dimensions of impulsivity as determinants of alcohol use and alcohol problems: risky decision-making, self-reported risk attitudes, response inhibition, and impulsive decision-making. Method Participants were a community sample of non-treatment seeking problem drinkers (N = 158). Structural Equation Modeling (SEM) analyses employed behavioral measures of impulsive decision-making (Delay Discounting Task, DDT), response inhibition (Stop Signal Task, SST), and risky decision-making (Balloon Analogue Risk Task, BART), and a self-report measure of risk attitudes (Domain-specific Risk-attitude Scale, DOSPERT), as predictors of alcohol use and of alcohol-related problems in this sample. Results The model fit well, accounting for 38% of the variance in alcohol problems, and identified two impulsivity dimensions that significantly loaded onto alcohol outcomes: (1) impulsive decision-making, indexed by the DDT; and (2) risky decision-making, measured by the BART. Conclusions The impulsive decision-making dimension of impulsivity, indexed by the DDT, was the strongest predictor of alcohol use and alcohol pathology in this sample of problem drinkers. Unexpectedly, a negative relationship was found between risky decision-making and alcohol problems. The results highlight the importance of considering the distinct facets of impulsivity in order to elucidate their individual and combined effects on alcohol use initiation, escalation, and dependence. PMID:22091877

Smoked cannabis' psychomotor and neurocognitive effects in occasional and frequent smokers.

PubMed

Desrosiers, Nathalie A; Ramaekers, Johannes G; Chauchard, Emeline; Gorelick, David A; Huestis, Marilyn A

2015-05-01

Δ9-Tetrahydrocannabinol (THC), the primary psychoactive constituent in cannabis, impairs psychomotor performance, cognition and driving ability; thus, driving under the influence of cannabis is a public safety concern. We documented cannabis' psychomotor, neurocognitive, subjective and physiological effects in occasional and frequent smokers to investigate potential differences between these smokers. Fourteen frequent (≥4x/week) and 11 occasional (<2x/week) cannabis smokers entered a secure research unit ∼19 h prior to smoking one 6.8% THC cigarette. Cognitive and psychomotor performance was evaluated with the critical tracking (CTT), divided attention (DAT), n-back (working memory) and Balloon Analog Risk (BART) (risk-taking) tasks at -1.75, 1.5, 3.5, 5.5 and 22.5 h after starting smoking. GLM (General Linear Model) repeated measures ANOVA was utilized to compare scores. Occasional smokers had significantly more difficulty compensating for CTT tracking error compared with frequent smokers 1.5 h after smoking. Divided attention performance declined significantly especially in occasional smokers, with session × group effects for tracking error, hits, false alarms and reaction time. Cannabis smoking did not elicit session × group effects on the n-back or BART. Controlled cannabis smoking impaired psychomotor function, more so in occasional smokers, suggesting some tolerance to psychomotor impairment in frequent users. These data have implications for cannabis-associated impairment in driving under the influence of cannabis cases. Published by Oxford University Press 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Functional Genetic Variation in Dopamine Signaling Moderates Prefrontal Cortical Activity During Risky Decision Making.

PubMed

Kohno, Milky; Nurmi, Erika L; Laughlin, Christopher P; Morales, Angelica M; Gail, Emma H; Hellemann, Gerhard S; London, Edythe D

2016-02-01

Brain imaging has revealed links between prefrontal activity during risky decision-making and striatal dopamine receptors. Specifically, striatal dopamine D2-like receptor availability is correlated with risk-taking behavior and sensitivity of prefrontal activation to risk in the Balloon Analogue Risk Task (BART). The extent to which these associations, involving a single neurochemical measure, reflect more general effects of dopaminergic functioning on risky decision making, however, is unknown. Here, 65 healthy participants provided genotypes and performed the BART during functional magnetic resonance imaging. For each participant, dopamine function was assessed using a gene composite score combining known functional variation across five genes involved in dopaminergic signaling: DRD2, DRD3, DRD4, DAT1, and COMT. The gene composite score was negatively related to dorsolateral prefrontal cortical function during risky decision making, and nonlinearly related to earnings on the task. Iterative permutations of all possible allelic variations (7777 allelic combinations) was tested on brain function in an independently defined region of the prefrontal cortex and confirmed empirical validity of the composite score, which yielded stronger association than 95% of all other possible combinations. The gene composite score also accounted for a greater proportion of variability in neural and behavioral measures than the independent effects of each gene variant, indicating that the combined effects of functional dopamine pathway genes can provide a robust assessment, presumably reflecting the cumulative and potentially interactive effects on brain function. Our findings support the view that the links between dopaminergic signaling, prefrontal function, and decision making vary as a function of dopamine signaling capacity.

Impulsivity, Sensation Seeking, and Risk-Taking Behaviors among HIV-Positive and HIV-Negative Heroin Dependent Persons

PubMed Central

Paydary, Koosha; Mahin Torabi, Somayeh; SeyedAlinaghi, SeyedAhmad; Noori, Mehri; Noroozi, Alireza; Ameri, Sara; Ekhtiari, Hamed

2016-01-01

Objective. The aim of this study was to compare impulsivity and risky decision making among HIV-positive and negative heroin dependent persons. Methods. We compared different dimensions of impulsivity and risky decision making in two groups of 60 HIV-positive and 60 HIV-negative male heroin dependent persons. Each group was comprised of equal numbers of current (treatment seeker) and former (abstinent) heroin addicts. Data collection tools included Balloon Analogue Risk Task (BART), Iowa Gambling Task (IGT), Barratt Impulsiveness Scale (BIS), and Zuckerman Sensation Seeking Scale (SSS). Results. In SSS, comprised of four subscales including thrill and adventure seeking (TAS), experience seeking (ES), disinhibition (DIS), and boredom susceptibility (BS), there was a borderline difference in DIS (P = 0.08) as HIV-positive group scored higher than HIV-negative group. Also, ES and total score were significantly higher among HIV-positive patients. In BART, HIV-positive subjects scored higher in risk taking than HIV-negative subjects as reflected in higher Average Number of puffs in Successful Balloons (ANSB). In BIS, HIV-positive group scored significantly higher in cognitive impulsivity (CI) (P = 0.03) and nonplanning impulsivity (NPI) (P = 0.05) in comparison to HIV-negative group. Also, current heroin addicts scored significantly higher in NPI compared to former addict HIV-negative participants (P = 0.015). IGT did not show any significant difference between groups. Conclusion. Higher levels of impulsivity and risk taking behaviors among HIV-positive heroin addicts will increase serious concerns regarding HIV transmission from this group to other opiate dependents and healthy people. PMID:27051528

Basic Microvascular Anastomosis Simulation Hub Microsurgery Course: An Innovative Competency-Based Approach to Microsurgical Training for Early Year's Plastic Surgery Trainees.

PubMed

Ali, Stephen

2018-04-01

Early year's plastic surgery trainees are faced with a large choice of microsurgery courses to select from. In the context of dwindling study budgets and busy on-call rotas, the pressure to select a high yield course that delivers value for money is of paramount importance.The Basic Microvascular Anastomosis Simulation Hub Microsurgery Course is a GBP £600 (US $790) 5-day 40-hour course based at Barts and The London School of Medicine and Dentistry increasing in popularity among junior trainees to fit this brief.

Measurement of the t anti-t production cross-section at √s = 1.96-TeV using lifetime tagging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Khanov, Alexander

2004-01-01

A measurement of the tmore » $$\\bar{t}$$ production cross section in the lepton+jets channels with the D0 detector at √s = 1.96 TeV using the lifetime-tagging techniques is presented. The t$$\\bar{t}$$ cross section is estimated from the combination of the e+jets and μ+jets channels. The obtained result σ t$$\\bar{t}$$ = 7.47$$+ 1.22\\atop{-1.14}$$(stat)$$+ 1.65\\atop{-1.03}$$(syst) ± 0.49(lumi) pb is consistent with the Standard Model expectation.« less

Automated generation of quantum-accurate classical interatomic potentials for metals and semiconductors

NASA Astrophysics Data System (ADS)

Thompson, Aidan; Foiles, Stephen; Schultz, Peter; Swiler, Laura; Trott, Christian; Tucker, Garritt

2013-03-01

Molecular dynamics (MD) is a powerful condensed matter simulation tool for bridging between macroscopic continuum models and quantum models (QM) treating a few hundred atoms, but is limited by the accuracy of available interatomic potentials. Sound physical and chemical understanding of these interactions have resulted in a variety of concise potentials for certain systems, but it is difficult to extend them to new materials and properties. The growing availability of large QM data sets has made it possible to use more automated machine-learning approaches. Bartók et al. demonstrated that the bispectrum of the local neighbor density provides good regression surrogates for QM models. We adopt a similar bispectrum representation within a linear regression scheme. We have produced potentials for silicon and tantalum, and we are currently extending the method to III-V compounds. Results will be presented demonstrating the accuracy of these potentials relative to the training data, as well as their ability to accurately predict material properties not explicitly included in the training data. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Dept. of Energy Nat. Nuclear Security Admin. under Contract DE-AC04-94AL85000.

Tests of Exoplanet Atmospheric Radiative Transfer Codes

NASA Astrophysics Data System (ADS)

Harrington, Joseph; Challener, Ryan; DeLarme, Emerson; Cubillos, Patricio; Blecic, Jasmina; Foster, Austin; Garland, Justin

2016-10-01

Atmospheric radiative transfer codes are used both to predict planetary spectra and in retrieval algorithms to interpret data. Observational plans, theoretical models, and scientific results thus depend on the correctness of these calculations. Yet, the calculations are complex and the codes implementing them are often written without modern software-verification techniques. In the process of writing our own code, we became aware of several others with artifacts of unknown origin and even outright errors in their spectra. We present a series of tests to verify atmospheric radiative-transfer codes. These include: simple, single-line line lists that, when combined with delta-function abundance profiles, should produce a broadened line that can be verified easily; isothermal atmospheres that should produce analytically-verifiable blackbody spectra at the input temperatures; and model atmospheres with a range of complexities that can be compared to the output of other codes. We apply the tests to our own code, Bayesian Atmospheric Radiative Transfer (BART) and to several other codes. The test suite is open-source software. We propose this test suite as a standard for verifying current and future radiative transfer codes, analogous to the Held-Suarez test for general circulation models. This work was supported by NASA Planetary Atmospheres grant NX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

Atlas-guided volumetric diffuse optical tomography enhanced by generalized linear model analysis to image risk decision-making responses in young adults.

PubMed

Lin, Zi-Jing; Li, Lin; Cazzell, Mary; Liu, Hanli

2014-08-01

Diffuse optical tomography (DOT) is a variant of functional near infrared spectroscopy and has the capability of mapping or reconstructing three dimensional (3D) hemodynamic changes due to brain activity. Common methods used in DOT image analysis to define brain activation have limitations because the selection of activation period is relatively subjective. General linear model (GLM)-based analysis can overcome this limitation. In this study, we combine the atlas-guided 3D DOT image reconstruction with GLM-based analysis (i.e., voxel-wise GLM analysis) to investigate the brain activity that is associated with risk decision-making processes. Risk decision-making is an important cognitive process and thus is an essential topic in the field of neuroscience. The Balloon Analog Risk Task (BART) is a valid experimental model and has been commonly used to assess human risk-taking actions and tendencies while facing risks. We have used the BART paradigm with a blocked design to investigate brain activations in the prefrontal and frontal cortical areas during decision-making from 37 human participants (22 males and 15 females). Voxel-wise GLM analysis was performed after a human brain atlas template and a depth compensation algorithm were combined to form atlas-guided DOT images. In this work, we wish to demonstrate the excellence of using voxel-wise GLM analysis with DOT to image and study cognitive functions in response to risk decision-making. Results have shown significant hemodynamic changes in the dorsal lateral prefrontal cortex (DLPFC) during the active-choice mode and a different activation pattern between genders; these findings correlate well with published literature in functional magnetic resonance imaging (fMRI) and fNIRS studies. Copyright © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.

Simultaneous antegrade/retrograde upper urinary tract access: Bart's modified lateral position for complex upper tract endourologic pathologic features.

PubMed

Moraitis, Konstantinos; Philippou, Prodromos; El-Husseiny, Tamer; Wazait, Hassan; Masood, Junaid; Buchholz, Noor

2012-02-01

To determine whether the Bart's modified lateral position is safe and effective for achieving simultaneous anterograde and retrograde access in complex upper urinary tract pathologic features. From November 2006 to September 2010, 45 procedures were performed, with the patients in the modified lateral position. The indication for these procedures was the presence of complex unilateral upper urinary tract pathologic features. The patients with muscular and/or skeletal abnormalities were excluded. All procedures were performed using simultaneous anterograde and retrograde access with the patient under general anesthesia. The preoperative investigation protocol included assessment of the stone burden and location using enhanced abdominal computed tomography. The patients were routinely examined 6 weeks after the procedure with a combination of plain abdominal radiography and renal ultrasonography. For patients treated for conditions causing upper urinary tract obstruction (pelviureteral junction obstruction and/or ureteral strictures), a mercaptoacetyltriglycine renography was performed at 4, 12, and 24 months postoperatively. The mean patient age was 51.2 years (range 17-79). Stone clearance was achieved by a single combined procedure in 36 patients (80%). Successful recanalization was achieved in all patients with pelviureteral junction obstruction and ureteral strictures. In 4 patients (8.8%), persistent hematuria was noted, and 2 patients (4.4%) developed postoperative urinary sepsis and were treated conservatively. Modification to the lateral position compares equally with contemporary percutaneous nephrolithotomy series. It provides wide exposure of the flank, allowing the choice of multiple access sites, enhanced control, and a wide angle for handling of the antegrade instruments. Two surgeons can work simultaneously, addressing complex endourologic pathologic features in high-risk patients. Copyright © 2012. Published by Elsevier Inc.

Greater Risk-Sensitivity of Dorsolateral Prefrontal Cortex in Young Smokers than in Nonsmokers

PubMed Central

Galván, Adriana; Schonberg, Tom; Mumford, Jeanette; Kohno, Milky; Poldrack, Russell A.; London, Edythe D.

2013-01-01

Rationale Despite a national reduction in the prevalence of cigarette smoking, ~19% of the adult U.S. population persists in this behavior, with the highest prevalence among 18–25-year-olds. Given that the choice to smoke imposes a known health risk, clarification of brain function related to decision-making, particularly involving risk-taking, in smokers may inform prevention and smoking cessation strategies. Objectives This study aimed to compare brain function related to decision-making in young smokers and nonsmokers. Methods The Balloon Analogue Risk Task (BART) is a computerized risky decision-making task in which participants pump virtual balloons, each pump associated with an incremental increase in potential payoff on a given trial but also with greater risk of balloon explosion and loss of payoff. We used this task to compare brain activation associated with risky decision-making in smokers (n=18) and nonsmokers (n=25) while they performed the BART during functional magnetic resonance imaging (fMRI). The participants were young men and women, 17–21 years of age. Results Risk level (number of pumps) modulated brain activation in the right dorsolateral and ventrolateral prefrontal cortices more in smokers than in nonsmokers; and smoking severity (Heaviness of Smoking Index) was positively related to this modulation in an adjacent frontal region. Conclusions Given evidence for involvement of the right dorsolateral and ventrolateral prefrontal cortices in inhibitory control, these findings suggest that young smokers have a different contribution of prefrontal cortical substrates to risky decision-making than nonsmokers. Future studies are warranted to determine whether the observed neurobiological differences precede or result from smoking. PMID:23644912

Screening for intermediate and severe forms of thalassaemia in discarded red blood cells: optimization and feasibility.

PubMed

George, Elizabeth; Lai, Mei I; Teh, Lai Kuan; Ramasamy, Rajesh; Goh, Ern Huei; Asokan, Kamalan; Tan, J A M A; Vasudevan, Maithili; Low, Sharon

2011-12-01

Detection and quantification of Hb subtypes of human blood is integral to presumptive identification of thalassaemias. It has been used in neonatal screening of thalassaemia and Hb variants. The use of discarded red blood cells following processing of the cord blood for stem cells provides readily available diagnostic material for thalassaemia screening. In this study, we determined the range of Hb subtypes in 195 consecutive cord blood samples collected for cord blood banking. The 'cord blood samples' analysed were those of the remaining red blood cells after the cord blood was processed for stem cell storage. Quantification of Hb subtypes by high performance liquid chromatography (HPLC) was done on BioRad Variant II Hb testing system. Only 73 (36.5%) of the samples could be analyzed neat without dilution. With a 1:300 dilution with wash solution the acceptable area as recommended by the manufacturer for reading of a C-gram within the 1 to 3 million ranges were achieved in all. Eighteen (9%) 12 showed classical Hb Barts (y4) prerun peaks were confirmed by Sebia Hydrasys automated Hb gel electrophoresis and quantified by Sebia Capillarys 2 capillary electrophoresis. Only 1 (0.5%) was presumptively identified with HbH disease. Due to the limited number of samples no beta-thalassaemia major, Hb E beta-thalassaemia and Hb Barts hydrops fetalis were found. The HPLC assay was possible at a cost US$ 5 per sample and a turnover time of 10 samples per hour without technical difficulties. This study reports an effective and valuable protocol for thalassaemia screening in red blood cells which would otherwise be discarded during cord blood processing. Cord blood with severe and intermediate forms of thalassaemia can be preselected and not stored.

Distribution of alpha thalassaemia in 16 year old Malaysian Students in Penang, Melaka and Sabah.

PubMed

Rahimah, A N; Nisha, S; Safiah, B; Roshida, H; Punithawathy, Y; Nurul, H; Syahzuwan, H; Zubaidah, Z

2012-12-01

Alpha thalassaemia is wide spread in Malaysia and is a public health problem. This study aimed to describe the carrier frequencies of α‒thalassaemia and its distribution among major ethnic groups in three states of Malaysia. Educational forums were organised and study was explained to students from three schools. Students were invited to take part in the screening with parent consent. A total of 8420 adolescent students aged 16 years volunteered to participate in the study. Peripheral blood samples were analysed for complete blood counts, haemoglobin quantification and typing, and serum ferritin levels. Genomic DNA was used for screening alpha thalassaemia alleles by PCR based molecular methods. We identified seven α‒globin gene defects in 341 (4.08%) students: amongst them α(+)‒ and α(0)‒thalassaemias were detected in 232 (2.77%) and 107 (1.28%) students respectively. Genotype ‒α(3.7)/αα was the most prevalent among sub-populations of Malay, indigenous communities of Sahab and Indian, while ‒‒(SEA)/αα deletion is more prevalent in Malaysian Chinese. It is estimated that 63 pregnancies annually are at risk of Hb Bart's hydrops fetalis. We have demonstrated the prevalence and mutation patterns of α‒thalassaemia in the 16 year olds in three states of Malaysia. High α(0)‒thalassaemia deletions amongst the study subjects place these carriers at an increased risk of conceiving fetuses with HbH disease and Hb Bart's hydrops fetalis should they choose another heterozygous partner. It is therefore highly recommended to institute community screening programmes and provide prospective carriers with genetic counselling to help them make informed choices.

Detection of SEA-type α-thalassemia in embryo biopsies by digital PCR.

PubMed

Lee, Ta-Hsien; Hsu, Ya-Chiung; Chang, Chia Lin

2017-08-01

Accurate and efficient pre-implantation genetic diagnosis (PGD) based on the analysis of single or oligo-cells is needed for timely identification of embryos that are affected by deleterious genetic traits in in vitro fertilization (IVF) clinics. Polymerase chain reaction (PCR) is the backbone of modern genetic diagnoses, and a spectrum of PCR-based techniques have been used to detect various thalassemia mutations in prenatal diagnosis (PND) and PGD. Among thalassemias, SEA-type α-thalassemia is the most common variety found in Asia, and can lead to Bart's hydrops fetalis and serious maternal complications. To formulate an efficient digital PCR for clinical diagnosis of SEA-type α-thalassemia in cultured embryos, we conducted a pilot study to detect the α-globin and SEA-type deletion alleles in blastomere biopsies with a highly sensitive microfluidics-based digital PCR method. Genomic DNA from embryo biopsy samples were extracted, and crude DNA extracts were first amplified by a conventional PCR procedure followed by a nested PCR reaction with primers and probes that are designed for digital PCR amplification. Analysis of microfluidics-based PCR reactions showed that robust signals for normal α-globin and SEA-type deletion alleles, together with an internal control gene, can be routinely generated using crude embryo biopsies after a 10 6 -fold dilution of primary PCR products. The SEA-type deletion in cultured embryos can be sensitively diagnosed with the digital PCR procedure in clinics. The adoption of this robust PGD method could prevent the implantation of IVF embryos that are destined to develop Bart's hydrops fetalis in a timely manner. The results also help inform future development of a standard digital PCR procedure for cost-effective PGD of α-thalassemia in a standard IVF clinic. Copyright © 2017. Published by Elsevier B.V.

76 FR 81727 - Approval and Promulgation of Implementation Plans; Oklahoma; Federal Implementation Plan for...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-28

...EPA is partially approving and partially disapproving a revision to the Oklahoma State Implementation Plan (SIP) submitted by the State of Oklahoma through the Oklahoma Department of Environmental Quality on February 19, 2010, intended to address the regional haze requirements of the Clean Air Act (CAA). In addition, EPA is partially approving and partially disapproving a portion of a revision to the Oklahoma SIP submitted by the State of Oklahoma on May 10, 2007 and supplemented on December 10, 2007 to address the requirements of CAA section 110(a)(2)(D)(i)(II) as it applies to visibility for the 1997 8- hour ozone and 1997 fine particulate matter National Ambient Air Quality Standards. This CAA requirement is intended to prevent emissions from one state from interfering with the visibility programs in another state. EPA is approving certain core elements of the SIP including Oklahoma's: determination of baseline and natural visibility conditions; coordinating regional haze and reasonably attributable visibility impairment; monitoring strategy and other implementation requirements; coordination with states and Federal Land Managers; and a number of NOX, SO2, and PM BART determinations. EPA is finding that Oklahoma's regional haze SIP did not address the sulfur dioxide Best Available Retrofit Technology requirements for six units in Oklahoma in accordance with the Regional Haze requirements, or the requirement to prevent interference with other states' visibility programs. EPA is promulgating a Federal Implementation Plan to address these deficiencies by requiring emissions to be reduced at these six units. This action is being taken under section 110 and part C of the CAA.

KSC-2011-1044

NASA Image and Video Library

2011-01-07

CAPE CANAVERAL, Fla. -- In the Launch Control Center at NASA's Kennedy Space Center in Florida, Bart Pannullo, the vehicle processing engineer for space shuttle Discovery, sits at his console in Firing Room 4 along with other STS-133 launch team members to rehearse procedures for the liftoff of Discovery's final mission. The team at Kennedy also participated in launch simulations with personnel at NASA's Johnson Space Center in Houston. Discovery's next launch opportunity to the International Space Station on the STS-133 mission is planned for no earlier than Feb. 24. For more information on STS-133, visit www.nasa.gov/mission_pages/shuttle/shuttlemissions/sts133/. Photo credit: NASA/Kim Shiflett

Dynamic expression of viral and cellular microRNAs in infectious mononucleosis caused by primary Epstein-Barr virus infection in children.

PubMed

Gao, Liwei; Ai, Junhong; Xie, Zhengde; Zhou, Chen; Liu, Chunyan; Zhang, Hui; Shen, Kunling

2015-12-03

Epstein-Barr virus (EBV) was the first virus identified to encode microRNAs (miRNAs). Both of viral and human cellular miRNAs are important in EBV infection. However, the dynamic expression profile of miRNAs during primary EBV infection was unknown. This study aimed to investigate the dynamic expression profile of viral and cellular miRNAs in infectious mononucleosis (IM) caused by primary EBV infection. The levels of viral and cellular miRNAs were measured in fifteen pediatric IM patients at three different time-points. Fifteen healthy children who were seropositive for EBV were enrolled in the control group. Relative expression levels of miRNAs were detected by quantitative real-time PCR (qPCR) assay. EBV-miR-BHRF1-1, 1-2-3P, miR-BART13-1, 19-3p, 11-3P, 12-1, and 16-1 in IM patients of early phase were significantly higher than in healthy children. Most cellular miRNAs of B cells, such as hsa-miR-155-5p, -34a-5p, -18b-5p, -181a-5p, and -142-5p were up-regulated; while most of cellular miRNAs of CD8 + T cells, such as hsa-miR-223, -29c-3p, -181a, -200a-3p, miR-155-5p, -146a, and -142-5p were down-regulated in IM patients. With disease progression, nearly all of EBV-miRNAs decreased, especially miR-BHRF1, but at a slower rate than EBV DNA loads. Most of the cellular miRNAs of B cells, including hsa-miR-134-5p, -18b-5p, -34a-5p, and -196a-5p increased with time. However, most of the cellular miRNAs of CD8 + T cells, including hsa-let-7a-5p, -142-3p, -142-5p, and -155-5p decreased with time. Additionally, hsa-miR-155-5p of B cells and hsa-miR-18b-5p of CD8+ T cells exhibited a positive correlation with miR-BHRF1-2-5P and miR-BART2-5P (0.96 ≤ r ≤ 0.99, P < 0.05). Finally, hsa-miR-181a-5p of B cells had positive correlation with miR-BART4-3p, 4-5P, 16-1, and 22 (0.97 ≤ r ≤ 0.99, P < 0.05). Our study is the first to describe the expression profile of viral and cellular miRNAs in IM caused by primary EBV infection. These results might be the basis of investigating the pathogenic mechanism of EBV-related diseases and bring new insights into their diagnosis and treatment.

Impact of attributed audit on procedural performance in cardiac electrophysiology catheter laboratory.

PubMed

Sawhney, V; Volkova, E; Shaukat, M; Khan, F; Segal, O; Ahsan, S; Chow, A; Ezzat, V; Finlay, M; Lambiase, P; Lowe, M; Dhinoja, M; Sporton, S; Earley, M J; Hunter, R J; Schilling, R J

2018-06-01

Audit has played a key role in monitoring and improving clinical practice. However, audit often fails to drive change as summative institutional data alone may be insufficient to do so. We hypothesised that the practice of attributed audit, wherein each individual's procedural performance is presented will have a greater impact on clinical practice. This hypothesis was tested in an observational study evaluating improvement in fluoroscopy times for AF ablation. Retrospective analyses of fluoroscopy times in AF ablations at the Barts Heart Centre (BHC) from 2012-2017. Fluoroscopy times were compared pre- and post- the introduction of attributed audit in 2012 at St Bartholomew's Hospital (SBH). In order to test the hypothesis, this concept was introduced to a second group of experienced operators from the Heart Hospital (HH) as part of a merger of the two institutions in 2015 and change in fluoroscopy times recorded. A significant drop in fluoroscopy times (33.3 ± 9.14 to 8.95 ± 2.50, p < 0.0001) from 2012-2014 was noted after the introduction of attributed audit. At the time of merger, a significant difference in fluoroscopy times between operators from the two centres was seen in 2015. Each operator's procedural performance was shared openly at the audit meeting. Subsequent audits showed a steady decrease in fluoroscopy times for each operator with the fluoroscopy time (min, mean±SD) decreasing from 13.29 ± 7.3 in 2015 to 8.84 ± 4.8 (p < 0.0001) in 2017 across the entire group. Systematic improvement in fluoroscopy times for AF ablation procedures was noted byevaluating individual operators' performance. Attributing data to physicians in attributed audit can promptsignificant improvement and hence should be adopted in clinical practice.

Atmospheric, Orbital and Secondary Eclipse Analysis of HAT-P-30-WASP-51b

NASA Astrophysics Data System (ADS)

Foster, Andrew S.; Harrington, Joseph; Cubillos, Patricio; Blecic, Jasmina; Challener, Ryan; Foster, Austin James; Garland, Justin

2016-01-01

HAT-P-30-WASP-51b is a hot-Jupiter planet that orbits an F star every 2.8106 days at a distance of 0.0419 AU. Using the Spitzer Space Telescope in 2012 (Spitzer Program Number 70084) we observed two secondary eclipses of the planet, one in the 3.6 μm channel on 3 January and one in the 4.5 μm channel on 17 January. We present eclipse-depth measurements of 0.00163±0.0001 and 0.00146±0.00013 and we esitmate the infrared brightness temperatures to be 1900±50 and 1600±60 for these two channels, respectively, from an analysis using our Photometry for Orbits, Eclipses, and Transits (POET) pipeline. We also refine its orbit using our own secondary-eclipse measurements in combination with radial-velocity and transit observations from both professional and amateur observers. The most notable result from this orbital analysis is a detection of eccentricity in the planet's orbit. Using only the phase of our secondary eclipses, we can constrain ecosw to a minimum of 0.0084±0.0004, a 20 sigma detection of one component of the orbit's eccentricity that is independent of the effects that stellar tides have on radial velocity data. We then characterize its atmosphere's temperature- pressure profile and molecular abundances using our Bayesian Atmospheric Radiative Transfer code (BART). Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G. J. Blecic holds a NASA Earth and Space Sciences Fellowship.

Atmospheric, Orbital and Eclipse Depth Analysis of the Hot Jupiter HAT-P-30-WASP-51b

NASA Astrophysics Data System (ADS)

Foster, Andrew S.; Harrington, Joseph; Cubillos, Patricio; Blecic, Jasmina; Foster, A. J.; Challener, Ryan; Garland, Justin

2015-11-01

HAT-P-30-WASP-51b is a hot-Jupiter planet that orbits an F star every 2.8106 days at a distance of 0.0419 AU. Using the Spitzer Space Telescope in 2012 (Spitzer Program Number 70084) we observed two secondary eclipses of the planet, one in the 3.6 μm channel on 3 January and one in the 4.5 μm channel on 17 January. We present eclipse-depth measurements of 0.00163 ± 0.0001 and 0.00146 ± 0.00013 and we esitmate the infrared brightness temperatures to be 1900 ± 50 and 1600 ± 60 for these two channels, respectively, from an analysis using our Photometry for Orbits, Eclipses, and Transits (POET) pipeline. We also refine its orbit using our own secondary-eclipse measurements in combination with radial-velocity and transit observations from both professional and amateur observers. The most notable result from this orbital analysis is a detection of eccentricity in the planet's orbit. Using only the phase of our secondary eclipses, we can constrain ecosw to a minimum of 0.0084 ± 0.0004, a 20 sigma detection of one component of the orbit's eccentricity that is independent of the effects that stellar tides have on radial velocity data. We then characterize its atmosphere's temperature- pressure profile and molecular abundances using our Bayesian Atmospheric Radiative Transfer code (BART). Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G. J. Blecic holds a NASA Earth and Space Science Fellowship.

Pixel-Level Decorrelation and BiLinearly Interpolated Subpixel Sensitivity applied to WASP-29b

NASA Astrophysics Data System (ADS)

Challener, Ryan; Harrington, Joseph; Cubillos, Patricio; Blecic, Jasmina; Deming, Drake

2017-10-01

Measured exoplanet transit and eclipse depths can vary significantly depending on the methodology used, especially at the low S/N levels in Spitzer eclipses. BiLinearly Interpolated Subpixel Sensitivity (BLISS) models a physical, spatial effect, which is independent of any astrophysical effects. Pixel-Level Decorrelation (PLD) uses the relative variations in pixels near the target to correct for flux variations due to telescope motion. PLD is being widely applied to all Spitzer data without a thorough understanding of its behavior. It is a mathematical method derived from a Taylor expansion, and many of its parameters do not have a physical basis. PLD also relies heavily on binning the data to remove short time-scale variations, which can artifically smooth the data. We applied both methods to 4 eclipse observations of WASP-29b, a Saturn-sized planet, which was observed twice with the 3.6 µm and twice with the 4.5 µm channels of Spitzer's IRAC in 2010, 2011 and 2014 (programs 60003, 70084, and 10054, respectively). We compare the resulting eclipse depths and midpoints from each model, assess each method's ability to remove correlated noise, and discuss how to choose or combine the best data analysis methods. We also refined the orbit from eclipse timings, detecting a significant nonzero eccentricity, and we used our Bayesian Atmospheric Radiative Transfer (BART) code to retrieve the planet's atmosphere, which is consistent with a blackbody. Spitzer is operated by the Jet Propulsion Laboratory, California Institute of Technology, under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

Research and test facilities

NASA Technical Reports Server (NTRS)

1993-01-01

A description is given of each of the following Langley research and test facilities: 0.3-Meter Transonic Cryogenic Tunnel, 7-by 10-Foot High Speed Tunnel, 8-Foot Transonic Pressure Tunnel, 13-Inch Magnetic Suspension & Balance System, 14-by 22-Foot Subsonic Tunnel, 16-Foot Transonic Tunnel, 16-by 24-Inch Water Tunnel, 20-Foot Vertical Spin Tunnel, 30-by 60-Foot Wind Tunnel, Advanced Civil Transport Simulator (ACTS), Advanced Technology Research Laboratory, Aerospace Controls Research Laboratory (ACRL), Aerothermal Loads Complex, Aircraft Landing Dynamics Facility (ALDF), Avionics Integration Research Laboratory, Basic Aerodynamics Research Tunnel (BART), Compact Range Test Facility, Differential Maneuvering Simulator (DMS), Enhanced/Synthetic Vision & Spatial Displays Laboratory, Experimental Test Range (ETR) Flight Research Facility, General Aviation Simulator (GAS), High Intensity Radiated Fields Facility, Human Engineering Methods Laboratory, Hypersonic Facilities Complex, Impact Dynamics Research Facility, Jet Noise Laboratory & Anechoic Jet Facility, Light Alloy Laboratory, Low Frequency Antenna Test Facility, Low Turbulence Pressure Tunnel, Mechanics of Metals Laboratory, National Transonic Facility (NTF), NDE Research Laboratory, Polymers & Composites Laboratory, Pyrotechnic Test Facility, Quiet Flow Facility, Robotics Facilities, Scientific Visualization System, Scramjet Test Complex, Space Materials Research Laboratory, Space Simulation & Environmental Test Complex, Structural Dynamics Research Laboratory, Structural Dynamics Test Beds, Structures & Materials Research Laboratory, Supersonic Low Disturbance Pilot Tunnel, Thermal Acoustic Fatigue Apparatus (TAFA), Transonic Dynamics Tunnel (TDT), Transport Systems Research Vehicle, Unitary Plan Wind Tunnel, and the Visual Motion Simulator (VMS).

Corrosion on Fatigue and Fatigue Crack Growth in Aircraft Structural Materials

DTIC Science & Technology

1979-06-01

nmonth- of 1Q730 v,’ ilc th au!Ihor xas. a! !Lockhehed Rvye (anyon Adva.nce,1d tj;ion in(I Research Laboratory. Mr. Gary Gos’s andl Mr. WValter Fitze ti...frtaerltd o11 1~ a cuea o rnicr srruae. 150x.IILI’ r11da- o p sdo’ l-akddi pe.Fgrc ()id4()c hl’ micro,,ructura ’Setd ~ ila i l--n ig ilc to ~IiiCId...bart 16 iretorted increcascd fatigue 0 t C Id ’ L5 treg th fof t eiii I Ic iti:ci st to L)i poic ed lirfe r; irnod a Ipho -teta or f inef~t

Scientists Look at 2010: Carrying on Margaret Mayall's Legacy of Debunking Pseudoscience

NASA Astrophysics Data System (ADS)

Larsen, Krinstine

2010-06-01

In 1941 Margaret Mayall, the future director of the AAVSO, and Harvard colleague Bart Bok authored a critical study of astrology and its impact on society entitled "Scientists Look at Astrology." They chastised the scientific community for thinking the debunking of astrology to be "below the dignity of scientists." In contrast, they opined that it is one of the duties of scientists to "inform the public about the nature and background of a current fad, such as astrology, even though to do so may be unpleasant." Fast-forward 68 years in the future, and the astronomical community now faces a pseudoscientific enemy just as insidious as astrology, yet just as ignored by the general professional and amateur community as astrology had been when Mayall and Bok took up the charge in 1941. The pseudoscience in question is the well-publicized "prediction" that the Mayan calendar will end on December 21, 2012, causing the end of civilization in concert with one of a number of possible astronomical calamities, including (but not limited to) the gravitational pull of the center of the Milky Way (somehow enhanced by an "alignment" with our solar system), the near-approach by a mythical 10th planet (often named Nibiru), large-scale damage to the planet by solar flares larger than those ever recorded, or the shifting of the earth's axis of rotation (often confused with a proposed sudden and catastrophic reversal of the earth's magnetic polarity). As a scientific and educational organization, the AAVSO and its members have a responsibility to follow in Mayall's footsteps, shining the light of reason and knowledge on the dark corners of ignorance which far too often permeate the Internet, radio and television programming, and recent films, most notably 2012. This talk will highlight some of the basic premises of the 2012 hysteria and suggest ways that the AAVSO and its members can use variable stars and the history of the AAVSO to counteract some of the astronomical misinformation which is increasingly promulgated by proponents of the 2012 pseudoscience.

Characterization of Unsteady Flow Structures Near Leading-Edge Slat. Part 1; PIV Measurements

NASA Technical Reports Server (NTRS)

Jenkins, Luther N.; Khorrami, Mehdi R.; Choudhari, Meelan

2004-01-01

A comprehensive computational and experimental study has been performed at the NASA Langley Research Center as part of the Quiet Aircraft Technology (QAT) Program to investigate the unsteady flow near a leading-edge slat of a two-dimensional, high-lift system. This paper focuses on the experimental effort conducted in the NASA Langley Basic Aerodynamics Research Tunnel (BART) where Particle Image Velocimetry (PIV) data was acquired in the slat cove and at the slat trailing edge of a three-element, high-lift model at 4, 6, and 8 degrees angle of attack and a freestream Mach Number of 0.17. Instantaneous velocities obtained from PIV images are used to obtain mean and fluctuating components of velocity and vorticity. The data show the recirculation in the cove, reattachment of the shear layer on the slat lower surface, and discrete vortical structures within the shear layer emanating from the slat cusp and slat trailing edge. Detailed measurements are used to examine the shear layer formation at the slat cusp, vortex shedding at the slat trailing edge, and convection of vortical structures through the slat gap. Selected results are discussed and compared with unsteady, Reynolds-Averaged Navier-Stokes (URANS) computations for the same configuration in a companion paper by Khorrami, Choudhari, and Jenkins (2004). The experimental dataset provides essential flow-field information for the validation of near-field inputs to noise prediction tools.

Translating Behavior Change Principles Into a Blended Exercise Intervention for Older Adults: Design Study.

PubMed

Mehra, Sumit; Visser, Bart; Dadema, Tessa; van den Helder, Jantine; Engelbert, Raoul Hh; Weijs, Peter Jm; Kröse, Ben Ja

2018-05-02

Physical activity can prevent or delay age-related impairments and prolong the ability of older adults to live independently. Community-based programs typically offer classes where older adults can exercise only once a week under the guidance of an instructor. The health benefits of such programs vary. Exercise frequency and the duration of the program play a key role in realizing effectiveness. An auxiliary home-based exercise program can provide older adults the opportunity to exercise more regularly over a prolonged period of time in the convenience of their own homes. Furthermore, mobile electronic devices can be used to motivate and remotely guide older adults to exercise in a safe manner. Such a blended intervention, where technology is combined with personal guidance, needs to incorporate behavior change principles to ensure effectiveness. The aim of this study was to identify theory-based components of a blended intervention that supports older adults to exercise at home. The Medical Research Council framework was used to develop the blended intervention. Insights from focus group, expert panels, and literature were combined into leading design considerations. A client-server system had been developed that combined a tablet app with a database in the cloud and a Web-based dashboard that can be used by a personal coach to remotely monitor and guide older adults. The app contains several components that facilitate behavior change-an interactive module for goal setting, the ability to draw up a personal training schedule from a library containing over 50 exercise videos, progress monitoring, and possibilities to receive remote feedback and guidance of a personal coach. An evidence-based blended intervention was designed to promote physical activity among older adults. The underlying design choices were underpinned by behavior change techniques that are rooted in self-regulation. Key components of the tablet-supported intervention were a tailored program that accommodates individual needs, demonstrations of functional exercises, monitoring, and remote feedback. The blended approach combines the convenience of a home-based exercise program for older adults with the strengths of mobile health and personal guidance. ©Sumit Mehra, Bart Visser, Tessa Dadema, Jantine van den Helder, Raoul HH Engelbert, Peter JM Weijs, Ben JA Kröse. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 02.05.2018.

Improved predictive mapping of indoor radon concentrations using ensemble regression trees based on automatic clustering of geological units.

PubMed

Kropat, Georg; Bochud, Francois; Jaboyedoff, Michel; Laedermann, Jean-Pascal; Murith, Christophe; Palacios Gruson, Martha; Baechler, Sébastien

2015-09-01

According to estimations around 230 people die as a result of radon exposure in Switzerland. This public health concern makes reliable indoor radon prediction and mapping methods necessary in order to improve risk communication to the public. The aim of this study was to develop an automated method to classify lithological units according to their radon characteristics and to develop mapping and predictive tools in order to improve local radon prediction. About 240 000 indoor radon concentration (IRC) measurements in about 150 000 buildings were available for our analysis. The automated classification of lithological units was based on k-medoids clustering via pair-wise Kolmogorov distances between IRC distributions of lithological units. For IRC mapping and prediction we used random forests and Bayesian additive regression trees (BART). The automated classification groups lithological units well in terms of their IRC characteristics. Especially the IRC differences in metamorphic rocks like gneiss are well revealed by this method. The maps produced by random forests soundly represent the regional difference of IRCs in Switzerland and improve the spatial detail compared to existing approaches. We could explain 33% of the variations in IRC data with random forests. Additionally, the influence of a variable evaluated by random forests shows that building characteristics are less important predictors for IRCs than spatial/geological influences. BART could explain 29% of IRC variability and produced maps that indicate the prediction uncertainty. Ensemble regression trees are a powerful tool to model and understand the multidimensional influences on IRCs. Automatic clustering of lithological units complements this method by facilitating the interpretation of radon properties of rock types. This study provides an important element for radon risk communication. Future approaches should consider taking into account further variables like soil gas radon measurements as well as more detailed geological information. Copyright © 2015 Elsevier Ltd. All rights reserved.

Behavioral measures of risk tasking, sensation seeking and sensitivity to reward may reflect different motivations for spicy food liking and consumption

PubMed Central

Byrnes, Nadia K.; Hayes, John E.

2016-01-01

Based on work a quarter century ago, it is widely accepted personality traits like sensation seeking are related to the enjoyment and intake of spicy foods; however, data supporting this belief is actually quite limited. Recently, we reported strong to moderate correlations between remembered spicy food liking and two personality traits measured with validated questionnaires. Here, participants consumed capsaicin-containing strawberry jelly to generate acute estimates of spicy food liking. Additionally, we used a laboratory-based behavioral measure of risk taking (the momentary Balloon Analogue Risk Task; mBART) to complement a range of validated self-report measures of risk-related personality traits. Present data confirm Sensation Seeking correlates with overall spicy meal liking and liking of the burn of a spicy meal, and extends prior findings by showing novel correlations with the liking of sampled stimuli. Other personality measures, including Sensitivity to Punishment (SP), Sensitivity to Reward (SR), and the Impulsivity and Risk Taking subscales of the DSM5 Personality Inventory (PID5) did not show significant relationships with liking of spicy foods, either sampled or remembered. Our behavioral risk taking measure, the mBART, also failed to show a relationship with remembered or sampled liking. However, significant relationships were observed between reported intake of spicy foods and Sensitivity to Reward, and the Risk Taking subscale of the PID-5 (PID5-RT). Based on the observed patterns among various personality measures, and spicy food liking and intake, we propose that personality measures may exert their influence on intake of spicy food via different mechanisms. We also speculate that Sensation Seeking may reflect motivations for consuming spicy foods that are more intrinsic, while the motivations for eating spicy foods measured by SR and PID5-RT may be more extrinsic. PMID:27137410

Behavioral measures of risk tasking, sensation seeking and sensitivity to reward may reflect different motivations for spicy food liking and consumption.

PubMed

Byrnes, Nadia K; Hayes, John E

2016-08-01

Based on work a quarter century ago, it is widely accepted personality traits like sensation seeking are related to the enjoyment and intake of spicy foods; however, data supporting this belief is actually quite limited. Recently, we reported strong to moderate correlations between remembered spicy food liking and two personality traits measured with validated questionnaires. Here, participants consumed capsaicin-containing strawberry jelly to generate acute estimates of spicy food liking. Additionally, we used a laboratory-based behavioral measure of risk taking (the mobile Balloon Analogue Risk Task; mBART) to complement a range of validated self-report measures of risk-related personality traits. Present data confirm Sensation Seeking correlates with overall spicy meal liking and liking of the burn of a spicy meal, and extends prior findings by showing novel correlations with the liking of sampled stimuli. Other personality measures, including Sensitivity to Punishment (SP), Sensitivity to Reward (SR), and the Impulsivity and Risk Taking subscales of the DSM5 Personality Inventory (PID-5) did not show significant relationships with liking of spicy foods, either sampled or remembered. Our behavioral risk taking measure, the mBART, also failed to show a relationship with remembered or sampled liking. However, significant relationships were observed between reported intake of spicy foods and Sensitivity to Reward, and the Risk Taking subscale of the PID-5 (PID5-RT). Based on the observed patterns among various personality measures, and spicy food liking and intake, we propose that personality measures may exert their influence on intake of spicy food via different mechanisms. We also speculate that Sensation Seeking may reflect motivations for consuming spicy foods that are more intrinsic, while the motivations for eating spicy foods measured by SR and PID5-RT may be more extrinsic. Copyright © 2016 Elsevier Ltd. All rights reserved.

The pathway to earthquake early warning in the US

NASA Astrophysics Data System (ADS)

Allen, R. M.; Given, D. D.; Heaton, T. H.; Vidale, J. E.; West Coast Earthquake Early Warning Development Team

2013-05-01

The development of earthquake early warning capabilities in the United States is now accelerating and expanding as the technical capability to provide warning is demonstrated and additional funding resources are making it possible to expand the current testing region to the entire west coast (California, Oregon and Washington). Over the course of the next two years we plan to build a prototype system that will provide a blueprint for a full public system in the US. California currently has a demonstrations warning system, ShakeAlert, that provides alerts to a group of test users from the public and private sector. These include biotech companies, technology companies, the entertainment industry, the transportation sector, and the emergency planning and response community. Most groups are currently in an evaluation mode, receiving the alerts and developing protocols for future response. The Bay Area Rapid Transit (BART) system is the one group who has now implemented an automated response to the warning system. BART now stops trains when an earthquake of sufficient size is detected. Research and development also continues to develop improved early warning algorithms to better predict the distribution of shaking in large earthquakes when the finiteness of the source becomes important. The algorithms under development include the use of both seismic and GPS instrumentation and integration with existing point source algorithms. At the same time, initial testing and development of algorithms in and for the Pacific Northwest is underway. In this presentation we will review the current status of the systems, highlight the new research developments, and lay out a pathway to a full public system for the US west coast. The research and development described is ongoing at Caltech, UC Berkeley, University of Washington, ETH Zurich, Southern California Earthquake Center, and the US Geological Survey, and is funded by the Gordon and Betty Moore Foundation and the US Geological Survey.

Monitoring of human brain functions in risk decision-making task by diffuse optical tomography using voxel-wise general linear model

NASA Astrophysics Data System (ADS)

Lin, Zi-Jing; Li, Lin; Cazzell, Marry; Liu, Hanli

2013-03-01

Functional near-infrared spectroscopy (fNIRS) is a non-invasive imaging technique which measures the hemodynamic changes that reflect the brain activity. Diffuse optical tomography (DOT), a variant of fNIRS with multi-channel NIRS measurements, has demonstrated capability of three dimensional (3D) reconstructions of hemodynamic changes due to the brain activity. Conventional method of DOT image analysis to define the brain activation is based upon the paired t-test between two different states, such as resting-state versus task-state. However, it has limitation because the selection of activation and post-activation period is relatively subjective. General linear model (GLM) based analysis can overcome this limitation. In this study, we combine the 3D DOT image reconstruction with GLM-based analysis (i.e., voxel-wise GLM analysis) to investigate the brain activity that is associated with the risk-decision making process. Risk decision-making is an important cognitive process and thus is an essential topic in the field of neuroscience. The balloon analogue risk task (BART) is a valid experimental model and has been commonly used in behavioral measures to assess human risk taking action and tendency while facing risks. We have utilized the BART paradigm with a blocked design to investigate brain activations in the prefrontal and frontal cortical areas during decision-making. Voxel-wise GLM analysis was performed on 18human participants (10 males and 8females).In this work, we wish to demonstrate the feasibility of using voxel-wise GLM analysis to image and study cognitive functions in response to risk decision making by DOT. Results have shown significant changes in the dorsal lateral prefrontal cortex (DLPFC) during the active choice mode and a different hemodynamic pattern between genders, which are in good agreements with published literatures in functional magnetic resonance imaging (fMRI) and fNIRS studies.

Successful ShakeAlert Performance for the Napa Quake

NASA Astrophysics Data System (ADS)

Allen, R. M.; Given, D. D.; Heaton, T. H.; Vidale, J. E.

2014-12-01

ShakeAlert, the demonstration earthquake early warning system, developed by the USGS, UC Berkeley, Caltech, ETH, and the University of Washington, functioned as expected for the August 24, 2014, M6.0 Napa earthquake. The first ShakeAlert was generated by the ElarmS algorithm 5.1 sec after the origin time of the earthquake, and 3.3 sec after the P-wave arrived at the closest station 6.5 km from the epicenter. This initial alert, based on P-wave triggers from four stations, estimated the magnitude to be 5.7. The warning was received at the UC Berkeley Seismological Laboratory 5 seconds before the S-wave and about 10 sec prior to the onset of the strongest shaking. ShakeAlert beta-testers across the San Francisco Bay Area simultaneously received the alert, including the San Francisco 911 center with 8 sec warning, and the BART train system. BART has implemented an automated train-stopping system that was activated (although no trains were running at 3:20 am). With the available network geometry and communications, the blind zone of the first alert had a radius of 16 km. The four stations that contributed to the first alert all encapsulate data into 1-second packets, but the latency in transmitting data to the processing center ranged from 0.27 to 2.62 seconds. If all the stations were to deliver data in 0.27 seconds, then the alert would have been available 2.3 sec sooner and the blind zone would be reduced to about 8 km. This would also mean that the city of Napa would have received about 1 second of warning. The magnitude estimate and event location were accurate from the initial alert onwards. The magnitude estimate did first increase to 5.8 and then dip to 5.4 2.6 sec after the initial alert, stayed at that level for 2 sec, and then returned to 5.7. The final magnitude estimate was 6.0, consistent with the ANSS catalog.

Diagnostic applications of newborn screening for α-thalassaemias, haemoglobins E and H disorders using isoelectric focusing on dry blood spots.

PubMed

Jindatanmanusan, Punyanuch; Riolueang, Suchada; Glomglao, Waraporn; Sukontharangsri, Yaowapa; Chamnanvanakij, Sangkae; Torcharus, Kitti; Viprakasit, Vip

2014-03-01

Neonatal screening for haemoglobin (Hb) disorders is a standard of care in several developed countries with the main objective to detect Hb S. Such practice has not been established in Thailand where α-thalassaemia and haemoglobin E (Hb E) are highly prevalent. Early identification of thalassaemias could be helpful and strengthen the programme for prevention and control for severe thalassaemias. Data from isoelectric focusing (IEF) and Isoscan® for detecting types and amount (%) of each haemoglobin in 350 newborn's dried blood spots were analysed and compared with the comprehensive genotype analysis by DNA studies as a gold standard. Based on genetic profiles, there were 10 different categories: (1) normal (n = 227), (2) α(+)-thalassaemia trait (n = 14), (3) α(0)-thalassaemia trait (n = 13), (4) β(0)-thalassaemia trait (n = 7), (5) Hb E trait (n = 72), (6) Hb E trait with α(0)-thalassaemia or homozygous α(+)-thalassaemia (n = 5), (7) Hb E trait with α(+)-thalassaemia trait (n = 5), (8) homozygous Hb E (n = 3), (9) homozygous Hb E with α(0)-thalassaemia trait (n = 1) and (10) Hb H disease (n = 3). The presence of Hb Bart's and Hb E were used to identify cases with α-thalassaemia and Hb E, respectively. We set 0.25% of Hb Bart's and 1.5% of Hb E as a cut-off level to detect α(+)-thalassaemia trait (sensitivity 92.86% and specificity 74.0%) and Hb E trait with 100% of both sensitivity and specificity for IEF diagnosis. Although molecular diagnosis seems to be better for definitive diagnosis of thalassaemia syndromes at birth, however, using our reference range described herein, IEF can be applied in a resource-limiting setting with acceptable reliability.

Status and needs for seismic instrumentation of structures along the Hayward fault

USGS Publications Warehouse

Kalkan, Erol; Çelebi, Mehmet

2008-01-01

The inventory of structures in heavily urbanized communities within the greater San Francisco (SF) Bay area that will experience strong ground motions from the rupture of the Hayward Fault includes a variety of types of recent and older structures built with a variety of materials and to different code standards. Those who remember the effects of the 1989 Loma Prieta earthquake on structures in the San Francisco Bay area also remember the collapse of one upper-deck segment of the Bay Bridge that halted transportation for approximately five weeks. In order to understand how these structures respond to earthquake motions and to improve building practices to resist these strong motions it is imperative that owners of these structures as well as governmental organizations acquire shaking response data from instrumented (or yet to be instrumented structures) during the forecast events. Within California, such data are acquired mainly by California Geological Survey and the United States Geological Survey. A small number of private owners contribute to this effort. The inventory of existing instrumented structures is much less than 0.1% of the total, and thus statistically it is not sufficient. For example, some of the existing important regular or lifeline structures are not instrumented(e.g. Bart Trans-Bay Tunnel, many segments of the Bart elevated structures in the proximity of the Hayward Fault, the yet to be completed eastern part of San Francisco Bay Bridge, Hetch-Hetchy pipeline system crossing the Hayward Fault)even though attempts and proposals have been developed to do so in the past. This paper presents a critical assessment of the status quo and the future needs for instrumentation of structures in the greater SF Bay area that includes the Hayward Fault. There are many new attempts and successes in instrumentation of structures in this region. Two successful examples are provided here, but more needs to be done. The paper does not present new research results; hence, it should be considered to be a “tutorial” paper.

Comparison of Engine/Inlet Distortion Measurements with MEMS and ESP Pressure Sensors

NASA Technical Reports Server (NTRS)

Soto, Hector L.; Hernandez, Corey D.

2004-01-01

A study of active-flow control in a small-scale boundary layer ingestion inlet was conducted at the NASA Langley Basic Aerodynamic Research Tunnel (BART). Forty MEMS pressure sensors, in a rake style configuration, were used to examine both the mean (DC) and high frequency (AC) components of the total pressure across the inlet/engine interface plane. The mean component was acquired and used to calculate pressure distortion. The AC component was acquired separately, at a high sampling rate, and is used to study the unsteady effects of the active-flow control. An identical total pressure rake, utilizing an Electronically Scanned Pressure (ESP) system, was also used to calculate distortion; a comparison of the results obtained using the two rakes is presented.

A minimum entropy principle in the gas dynamics equations

NASA Technical Reports Server (NTRS)

Tadmor, E.

1986-01-01

Let u(x bar,t) be a weak solution of the Euler equations, governing the inviscid polytropic gas dynamics; in addition, u(x bar, t) is assumed to respect the usual entropy conditions connected with the conservative Euler equations. We show that such entropy solutions of the gas dynamics equations satisfy a minimum entropy principle, namely, that the spatial minimum of their specific entropy, (Ess inf s(u(x,t)))/x, is an increasing function of time. This principle equally applies to discrete approximations of the Euler equations such as the Godunov-type and Lax-Friedrichs schemes. Our derivation of this minimum principle makes use of the fact that there is a family of generalized entrophy functions connected with the conservative Euler equations.

Outcome Probability versus Magnitude: When Waiting Benefits One at the Cost of the Other

PubMed Central

Young, Michael E.; Webb, Tara L.; Rung, Jillian M.; McCoy, Anthony W.

2014-01-01

Using a continuous impulsivity and risk platform (CIRP) that was constructed using a video game engine, choice was assessed under conditions in which waiting produced a continuously increasing probability of an outcome with a continuously decreasing magnitude (Experiment 1) or a continuously increasing magnitude of an outcome with a continuously decreasing probability (Experiment 2). Performance in both experiments reflected a greater desire for a higher probability even though the corresponding wait times produced substantive decreases in overall performance. These tendencies are considered to principally reflect hyperbolic discounting of probability, power discounting of magnitude, and the mathematical consequences of different response rates. Behavior in the CIRP is compared and contrasted with that in the Balloon Analogue Risk Task (BART). PMID:24892657

Emotional intelligence, risk perception in abstinent cocaine dependent individuals.

PubMed

Romero-Ayuso, Dulce; Mayoral-Gontán, Yolanda; Triviño-Juárez, José-Matías

2016-01-01

Cocaine is now responsible for the second-highest number of cessation intervention requests. In this study we analyze the different skills of emotional intelligence in cocaine- dependent patients maintaining abstinence. The Mayer- Salovey-Caruso Emotional Intelligence Test (MSCEIT) and the Balloon Analogue Risk Task (BART) were administered to 50 subjects (25 individuals with no history of drug use and 25 individuals in treatment at the Addictive Behaviors Unit in a state of withdrawal at the time of evaluation). The results showed differences between these groups in overall emotional intelligence quotient, strategic emotional intelligence, understanding emotions and emotional management. Cocaine-addicted participants showed difficulties in analyzing complex emotions and regulating their emotional response, aspects that can interfere with interactions in daily life.

Earthquake Early Warning: A Prospective User's Perspective (Invited)

NASA Astrophysics Data System (ADS)

Nishenko, S. P.; Savage, W. U.; Johnson, T.

2009-12-01

With more than 25 million people at risk from high hazard faults in California alone, Earthquake Early Warning (EEW) presents a promising public safety and emergency response tool. EEW represents the real-time end of an earthquake information spectrum which also includes near real-time notifications of earthquake location, magnitude, and shaking levels; as well as geographic information system (GIS)-based products for compiling and visually displaying processed earthquake data such as ShakeMap and ShakeCast. Improvements to and increased multi-national implementation of EEW have stimulated interest in how such information products could be used in the future. Lifeline organizations, consisting of utilities and transportation systems, can use both onsite and regional EEW information as part of their risk management and public safety programs. Regional EEW information can provide improved situational awareness to system operators before automatic system protection devices activate, and allow trained personnel to take precautionary measures. On-site EEW is used for earthquake-actuated automatic gas shutoff valves, triggered garage door openers at fire stations, system controls, etc. While there is no public policy framework for preemptive, precautionary electricity or gas service shutdowns by utilities in the United States, gas shut-off devices are being required at the building owner level by some local governments. In the transportation sector, high-speed rail systems have already demonstrated the ‘proof of concept’ for EEW in several countries, and more EEW systems are being installed. Recently the Bay Area Rapid Transit District (BART) began collaborating with the California Integrated Seismic Network (CISN) and others to assess the potential benefits of EEW technology to mass transit operations and emergency response in the San Francisco Bay region. A key issue in this assessment is that significant earthquakes are likely to occur close to or within the BART system, limiting the time available for an EEW-based response (i.e., slowing or stopping trains). While EEW systems are currently being tested in California, the societal benefits may be even more pronounced in other earthquake-prone parts of the United States. In the central and eastern United States, strong ground motions are felt over significantly larger areas than in California, enabling both a larger area and longer lead times for warnings ahead of the arrival of strong shaking. Because these regions are less resistant to earthquake shaking, such warnings may be even more important for safety and emergency response. However, in many areas a significant increase in the instrumentation density would be required for EEW to become a reality. Although the details of EEW systems are specific to earthquakes, the operation of sensor networks, real-time data analysis, and rapid notification to lifelines is an emerging technology that can be used for real-time detection and early warning of other types of natural and human-caused disasters and emergencies.

Quantitative multi-target RNA profiling in Epstein-Barr virus infected tumor cells.

PubMed

Greijer, A E; Ramayanti, O; Verkuijlen, S A W M; Novalić, Z; Juwana, H; Middeldorp, J M

2017-03-01

Epstein-Barr virus (EBV) is etiologically linked to multiple acute, chronic and malignant diseases. Detection of EBV-RNA transcripts in tissues or biofluids besides EBV-DNA can help in diagnosing EBV related syndromes. Sensitive EBV transcription profiling yields new insights on its pathogenic role and may be useful for monitoring virus targeted therapy. Here we describe a multi-gene quantitative RT-PCR profiling method that simultaneously detects a broad spectrum (n=16) of crucial latent and lytic EBV transcripts. These transcripts include (but are not restricted to), EBNA1, EBNA2, LMP1, LMP2, BARTs, EBER1, BARF1 and ZEBRA, Rta, BGLF4 (PK), BXLF1 (TK) and BFRF3 (VCAp18) all of which have been implicated in EBV-driven oncogenesis and viral replication. With this method we determine the amount of RNA copies per infected (tumor) cell in bulk populations of various origin. While we confirm the expected RNA profiles within classic EBV latency programs, this sensitive quantitative approach revealed the presence of rare cells undergoing lytic replication. Inducing lytic replication in EBV tumor cells supports apoptosis and is considered as therapeutic approach to treat EBV-driven malignancies. This sensitive multi-primed quantitative RT-PCR approach can provide broader understanding of transcriptional activity in latent and lytic EBV infection and is suitable for monitoring virus-specific therapy responses in patients with EBV associated cancers. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

A new gene deletion in the alpha-like globin gene cluster as the molecular basis for the rare alpha-thalassemia-1(--/alpha alpha) in blacks: HbH disease in sickle cell trait.

PubMed

Steinberg, M H; Coleman, M B; Adams, J G; Hartmann, R C; Saba, H; Anagnou, N P

1986-02-01

A novel deletion of at least 26 kilobase of DNA, including both alpha-globin genes, the psi alpha- and psi zeta-globin genes, but sparing the functional zeta-gene was found in a 10-year-old black boy with HbH disease and sickle cell trait. This particular deletion has not previously been described in blacks. Its existence makes it likely that the absence of Hb Barts hydrops fetalis in blacks is due to the rarity of the chromosome lacking two alpha-globin genes rather than a result of early embryonic death due to the failure to synthesize embryonic hemoglobins because of deletion of functional zeta-globin genes.

The Epstein Barr-encoded BART-6-3p microRNA affects regulation of cell growth and immuno response in Burkitt lymphoma

PubMed Central

2014-01-01

Background Burkitt lymphoma is an aggressive B-cell lymphoma presenting in three clinical forms: endemic, sporadic and immunodeficiency-associated. More than 90% of endemic Burkitt lymphoma carry latent Epstein-Barr virus, whereas only 20% of sporadic Burkitt lymphoma are associated with Epstein-Barr infection. Although the Epstein-Barr virus is highly related with the endemic form, how and whether the virus participates in its pathogenesis remains to be fully elucidated. In particular, the virus may impair cellular gene expression by its own encoded microRNAs. Methods Using microRNA profiling we compared Epstein-Barr-positive and Epstein-Barr-negative Burkitt lymphoma cases for both cellular and viral microRNAs. The array results were validated by qRT-PCR, and potential targets of viral microRNAs were then searched by bioinformatic predictions, and classified in functional categories, according to the Gene Ontology. Our findings were validated by in vitro functional studies and by immunohistochemistry on a larger series of cases. Results We showed that a few cellular microRNAs are differentially expressed between Epstein-Barr-positive and Epstein-Barr-negative Burkitt lymphoma cases, and identified a subset of viral microRNAs expressed in Epstein-Barr-positive Burkitt lymphomas. Of these, we characterized the effects of viral BART6-3p on regulation of cellular genes. In particular, we analyzed the IL-6 receptor genes (IL-6Rα and IL-6ST), PTEN and WT1 expression for their possible relevance to Burkitt lymphoma. By means of immunohistochemistry, we observed a down-regulation of the IL-6 receptor and PTEN specifically in Epstein-Barr-positive Burkitt lymphoma cases, which may result in the impairment of key cellular pathways and may contribute to malignant transformation. On the contrary, no differences were observed between Epstein-Barr-positive and Epstein-Barr-negative Burkitt lymphoma cases for WT1 expression. Conclusions Our preliminary results point at an active role for the Epstein-Barr virus in Burkitt lymphomagenesis and suggest new possible mechanisms used by the virus in determining dysregulation of the host cell physiology. PMID:24731550

The Epstein Barr-encoded BART-6-3p microRNA affects regulation of cell growth and immuno response in Burkitt lymphoma.

PubMed

Ambrosio, Maria Raffaella; Navari, Mohsen; Di Lisio, Lorena; Leon, Eduardo Andres; Onnis, Anna; Gazaneo, Sara; Mundo, Lucia; Ulivieri, Cristina; Gomez, Gonzalo; Lazzi, Stefano; Piris, Miguel Angel; Leoncini, Lorenzo; De Falco, Giulia

2014-01-01

Burkitt lymphoma is an aggressive B-cell lymphoma presenting in three clinical forms: endemic, sporadic and immunodeficiency-associated. More than 90% of endemic Burkitt lymphoma carry latent Epstein-Barr virus, whereas only 20% of sporadic Burkitt lymphoma are associated with Epstein-Barr infection. Although the Epstein-Barr virus is highly related with the endemic form, how and whether the virus participates in its pathogenesis remains to be fully elucidated. In particular, the virus may impair cellular gene expression by its own encoded microRNAs. Using microRNA profiling we compared Epstein-Barr-positive and Epstein-Barr-negative Burkitt lymphoma cases for both cellular and viral microRNAs. The array results were validated by qRT-PCR, and potential targets of viral microRNAs were then searched by bioinformatic predictions, and classified in functional categories, according to the Gene Ontology. Our findings were validated by in vitro functional studies and by immunohistochemistry on a larger series of cases. We showed that a few cellular microRNAs are differentially expressed between Epstein-Barr-positive and Epstein-Barr-negative Burkitt lymphoma cases, and identified a subset of viral microRNAs expressed in Epstein-Barr-positive Burkitt lymphomas. Of these, we characterized the effects of viral BART6-3p on regulation of cellular genes. In particular, we analyzed the IL-6 receptor genes (IL-6Rα and IL-6ST), PTEN and WT1 expression for their possible relevance to Burkitt lymphoma. By means of immunohistochemistry, we observed a down-regulation of the IL-6 receptor and PTEN specifically in Epstein-Barr-positive Burkitt lymphoma cases, which may result in the impairment of key cellular pathways and may contribute to malignant transformation. On the contrary, no differences were observed between Epstein-Barr-positive and Epstein-Barr-negative Burkitt lymphoma cases for WT1 expression. Our preliminary results point at an active role for the Epstein-Barr virus in Burkitt lymphomagenesis and suggest new possible mechanisms used by the virus in determining dysregulation of the host cell physiology.

Construction of environmental risk score beyond standard linear models using machine learning methods: application to metal mixtures, oxidative stress and cardiovascular disease in NHANES.

PubMed

Park, Sung Kyun; Zhao, Zhangchen; Mukherjee, Bhramar

2017-09-26

There is growing concern of health effects of exposure to pollutant mixtures. We initially proposed an Environmental Risk Score (ERS) as a summary measure to examine the risk of exposure to multi-pollutants in epidemiologic research considering only pollutant main effects. We expand the ERS by consideration of pollutant-pollutant interactions using modern machine learning methods. We illustrate the multi-pollutant approaches to predicting a marker of oxidative stress (gamma-glutamyl transferase (GGT)), a common disease pathway linking environmental exposure and numerous health endpoints. We examined 20 metal biomarkers measured in urine or whole blood from 6 cycles of the National Health and Nutrition Examination Survey (NHANES 2003-2004 to 2013-2014, n = 9664). We randomly split the data evenly into training and testing sets and constructed ERS's of metal mixtures for GGT using adaptive elastic-net with main effects and pairwise interactions (AENET-I), Bayesian additive regression tree (BART), Bayesian kernel machine regression (BKMR), and Super Learner in the training set and evaluated their performances in the testing set. We also evaluated the associations between GGT-ERS and cardiovascular endpoints. ERS based on AENET-I performed better than other approaches in terms of prediction errors in the testing set. Important metals identified in relation to GGT include cadmium (urine), dimethylarsonic acid, monomethylarsonic acid, cobalt, and barium. All ERS's showed significant associations with systolic and diastolic blood pressure and hypertension. For hypertension, one SD increase in each ERS from AENET-I, BART and SuperLearner were associated with odds ratios of 1.26 (95% CI, 1.15, 1.38), 1.17 (1.09, 1.25), and 1.30 (1.20, 1.40), respectively. ERS's showed non-significant positive associations with mortality outcomes. ERS is a useful tool for characterizing cumulative risk from pollutant mixtures, with accounting for statistical challenges such as high degrees of correlations and pollutant-pollutant interactions. ERS constructed for an intermediate marker like GGT is predictive of related disease endpoints.

Development and preliminary validation of a behavioral task of negative reinforcement underlying risk taking and its relation to problem alcohol use in college freshmen

PubMed Central

MacPherson, Laura; Calvin, Nicholas T.; Richards, Jessica M.; Guller, Leila; Mayes, Linda C.; Crowley, Michael J.; Daughters, Stacey B.; Lejuez, C.W.

2011-01-01

Background A long line of theoretical and empirical evidence implicates negative reinforcement as a process underlying the etiology and maintenance of risky alcohol use behaviors from adolescence through emerging adulthood. However, the bulk of this literature has relied on self-report measures and there is a notable absence of behavioral modes of assessments of negative reinforcement-based alcohol-related risk-taking. To address this clear gap in the literature, the current study presents the first published data on the reliability and validity of the Maryland Resource for the Behavioral Utilization of the Reinforcement of Negative Stimuli (MRBURNS), which is a modified version of the positive reinforcement-based Balloon Analogue Risk Task (BART). Methods Participants included a convenience sample of 116 college freshmen ever regular drinkers (aged 18–19) who completed both behavioral tasks; self-report measures of negative reinforcement/avoidance constructs and of positive reinforcement/appetitive constructs to examine convergent validity and discriminant validity, respectively; and self-report measures of alcohol use, problems, and motives to examine criterion validity. Results The MRBURNS evidenced sound experimental properties and reliability across task trials. In support of convergent validity, risk taking on the MRBURNS correlated significantly with negative urgency, difficulties in emotion regulation and depressive and anxiety-related symptoms. In support of discriminant validity, performance on the MRBURNS was unrelated to risk taking on the BART, sensation seeking, and trait impulsivity. Finally, pertaining to criterion validity, risk taking on the MRBURNS was related to alcohol-related problems but not heavy episodic alcohol use. Notably, risk taking on the MRBURNS was associated with negative reinforcement-based but not with positive reinforcement-based drinking motives. Conclusions Data from this initial investigation suggest the utility of the MRBURNS as a behavioral measure of negative-reinforcement based risk-taking that can provide a useful compliment to existing self-report measures to improve our understanding of the relationship between avoidant reinforcement processes and risky alcohol use. PMID:22309846

Measurement of HbA1c and HbA2 by Capillarys 2 Flex Piercing HbA1c programme for simultaneous management of diabetes and screening for thalassemia.

PubMed

Ke, Peifeng; Liu, Jiawei; Chao, Yan; Wu, Xiaobin; Xiong, Yujuan; Lin, Li; Wan, Zemin; Wu, Xinzhong; Xu, Jianhua; Zhuang, Junhua; Huang, Xianzhang

2017-10-01

Thalassemia could interfere with some assays for haemoglobin A 1c (HbA 1c ) measurement, therefore, it is useful to be able to screen for thalassemia while measuring HbA 1c . We used Capillarys 2 Flex Piercing (Capillarys 2FP) HbA 1c programme to simultaneously measure HbA 1c and screen for thalassemia. Samples from 498 normal controls and 175 thalassemia patients were analysed by Capillarys 2FP HbA 1c programme (Sebia, France). For method comparison, HbA 1c was quantified by Premier Hb9210 (Trinity Biotech, Ireland) in 98 thalassaemia patients samples. For verification, HbA 1c from eight thalassaemia patients was confirmed by IFCC reference method. Among 98 thalassaemia samples, Capillarys 2FP did not provide an HbA 1c result in three samples with HbH due to the overlapping of HbBart's with HbA 1c fraction; for the remaining 95 thalassaemia samples, Bland-Altman plot showed 0.00 ± 0.35% absolute bias between two systems, and a significant positive bias above 7% was observed only in two HbH samples. The HbA 1c values obtained by Capillarys 2FP were consistent with the IFCC targets (relative bias below ± 6%) in all of the eight samples tested by both methods. For screening samples with alpha (α-) thalassaemia silent/trait or beta (β-) thalassemia trait, the optimal HbA 2 cut-off values were ≤ 2.2% and > 2.8%, respectively. Our results demonstrated the Capillarys 2FP HbA 1c system could report an accurate HbA 1c value in thalassemia silent/trait, and HbA 2 value (≤ 2.2% for α-thalassaemia silent/trait and > 2.8% for β-thalassemia trait) and abnormal bands (HbH and/or HbBart's for HbH disease, HbF for β-thalassemia) may provide valuable information for screening.

The Implications of 3D Thermal Structure on 1D Atmospheric Retrieval

NASA Astrophysics Data System (ADS)

Blecic, Jasmina; Dobbs-Dixon, Ian; Greene, Thomas

2017-10-01

Using the atmospheric structure from a 3D global radiation-hydrodynamic simulation of HD 189733b and the open-source Bayesian Atmospheric Radiative Transfer (BART) code, we investigate the difference between the secondary-eclipse temperature structure produced with a 3D simulation and the best-fit 1D retrieved model. Synthetic data are generated by integrating the 3D models over the Spitzer, the Hubble Space Telescope (HST), and the James Web Space Telescope (JWST) bandpasses, covering the wavelength range between 1 and 11 μm where most spectroscopically active species have pronounced features. Using the data from different observing instruments, we present detailed comparisons between the temperature-pressure profiles recovered by BART and those from the 3D simulations. We calculate several averages of the 3D thermal structure and explore which particular thermal profile matches the retrieved temperature structure. We implement two temperature parameterizations that are commonly used in retrieval to investigate different thermal profile shapes. To assess which part of the thermal structure is best constrained by the data, we generate contribution functions for our theoretical model and each of our retrieved models. Our conclusions are strongly affected by the spectral resolution of the instruments included, their wavelength coverage, and the number of data points combined. We also see some limitations in each of the temperature parametrizations, as they are not able to fully match the complex curvatures that are usually produced in hydrodynamic simulations. The results show that our 1D retrieval is recovering a temperature and pressure profile that most closely matches the arithmetic average of the 3D thermal structure. When we use a higher resolution, more data points, and a parametrized temperature profile that allows more flexibility in the middle part of the atmosphere, we find a better match between the retrieved temperature and pressure profile and the arithmetic average. The Spitzer and HST simulated observations sample deep parts of the planetary atmosphere and provide fewer constraints on the temperature and pressure profile, while the JWST observations sample the middle part of the atmosphere, providing a good match with the middle and most complex part of the arithmetic average of the 3D temperature structure.

Reward-Seeking Behavior in Human Narcolepsy

PubMed Central

Dimitrova, Alexandra; Fronczek, Rolf; Van der Ploeg, Janneke; Scammell, Thomas; Gautam, Shiva; Pascual-Leone, Alvaro; Lammers, Gert Jan

2011-01-01

Study Objectives: The hypocretin system enhances signaling in the mesolimbic pathways regulating reward processing and addiction. Because individuals with narcolepsy with cataplexy have low hypocretin levels, we hypothesized that they may be less prone to risk- and reward-seeking behaviors, including substance abuse. Design: Endpoints were performance on an array of psychometric tests (including the Eysenck Impulsiveness Scale, the Zuckerman Sensation Seeking Scale, the Gormally Binge Eating Scale, and the Beck Depression and Anxiety Inventory) and on the Balloon Analogue Risk Task (BART). Setting: Tertiary narcolepsy referral centers in Leiden (The Netherlands) and Boston (USA). Patients: Subjects with narcolepsy with cataplexy (n = 30), narcolepsy without cataplexy (n = 15), and controls (n = 32) matched for age, sex, and smoking behavior. Interventions: None. Measurements and Results: There was no difference in risk-taking behavior between narcolepsy with or without cataplexy and the control group, as measured using the BART and the array of questionnaires. However, subjects in the narcolepsy with cataplexy group had significantly higher scores on the Eysenck Impulsiveness Scale (p < 0.05), with 10.0% categorized as impulsive, compared to 6.7% of the narcolepsy without cataplexy group and none of the controls. Narcoleptics with cataplexy also scored significantly higher than controls on the Binge Eating Scale (p < 0.05), with moderate or severe binge eating in 23%. On the depression and anxiety scales, all narcolepsy patients, especially those with cataplexy, scored significantly higher than controls. Conclusions: We found that narcoleptics with or without cataplexy generally have normal risk-taking behavior, but narcoleptics with cataplexy were more impulsive and more prone to binge eating than patients without cataplexy and controls. Our findings shed new light on the relation between sleepiness and impulsiveness. Furthermore, rates of depression and anxiety were higher in all narcoleptic subjects. However, using the current methods, no evidence could be found to support the hypothesis that hypocretin deficiency would affect reward-processing in humans. Citation: Dimitrova A; Fronczek R; Van der Ploeg J; Scammell T; Gautam S; Pascual-Leone A; Lammers GJ. Reward-seeking behavior in human narcolepsy. J Clin Sleep Med 2011;7(3):293-300. PMID:21677900

Programs to improve adolescent sexual and reproductive health in the US: a review of the evidence.

PubMed

Manlove, Jennifer; Fish, Heather; Moore, Kristin Anderson

2015-01-01

US adolescents have high rates of teen pregnancy, childbearing, and sexually transmitted infections (STIs), highlighting the need to identify and implement effective programs that will help improve teen sexual and reproductive health. This review identified 103 random-assignment evaluations of 85 programs that incorporated intent-to-treat analyses and assessed impacts on pregnancy, childbearing, STIs, and their key determinants - sexual activity, number of sexual partners, condom use, and other contraceptive use - among teens. This review describes the evidence base for five broad program approaches, including abstinence education, comprehensive sex education, clinic-based programs, youth development programs, and parent-youth relationship programs. We also describe programs with impacts on key outcomes, including pregnancy/childbearing, STIs, and those that found impacts on both sexual activity and contraceptive use. Our review identified 52 effective programs: 38 with consistent impacts on reproductive health outcomes, and 14 with mixed findings (across subpopulations, follow-ups, or multiple measures of a single outcome). We found that a variety of program approaches produced impacts on sexual and reproductive health outcomes. Parent-youth relationship programs and clinic-based program evaluations more frequently showed impacts than other program approaches, although we also identified a number of abstinence-education, comprehensive sex education, and youth-development programs with impacts on sexual and reproductive health outcomes. Overall, we identified nine program evaluations with impacts on teen pregnancies or births, five with impacts on reducing STIs, and 15 with impacts on both delaying/reducing sexual activity and increasing contraceptive use (including condom use). Future efforts should conduct replications of existing program evaluations, identify implementation components linked to impacts, rigorously evaluate programs that appear promising, and expand the evidence base on programs that impact hormonal and long-acting contraceptive method use.

International differences in sport medicine access and clinical management

PubMed Central

Heron, Neil; Malliaropoulos, Nikolaos G.

2012-01-01

Summary I undertook the 2012 ECOSEP travelling fellowship, sponsored by Bauerfeind, between May and August 2012, which involved visiting 5 European sport medicine centres and spending approximately one week in each centre. The 5 centres included: National Track and Field Centre, SEGAS, Thessaloniki, Greece; Professional School in Sport & Exercise Medicine, University of Barcelona, Spain; Sport Medicine Frankfurt Institute, Germany; Isokinetic Medical Group, FIFA Medical Centre of Excellence, Bologna, Italy, and Centre for Sports and Exercise Medicine, Barts and the London School of Medicine and Dentistry, Mile End Hospital, England. Throughout the fellowship, the clinical cases which were routinely encountered were documented. The following sections detail my experiences throughout the fellowship, the sports of the athletes and the injuries which were treated at each of the sport medicine centres during the fellowship visit and the different forms of management employed. PMID:23738305

Erratum: Measurement of the $$t \\bar{t}$$ production cross section in the dilepton channel in pp collisions at $$\\sqrt{s}$$ = 8 TeV

DOE PAGES

Chatrchyan, Serguei

2014-02-05

In this study, the top-antitop quark (tt¯) production cross section is measured in proton-proton collisions at √s = 8 TeV with the CMS experiment at the LHC, using a data sample corresponding to an integrated luminosity of 5.3 fb –1. The measurement is performed by analysing events with a pair of electrons or muons, or one electron and one muon, and at least two jets, one of which is identified as originating from hadronisation of a bottom quark. The measured cross section is 239±2 (stat.)±11 (syst.)±6 (lum.) pb, for an assumed top-quark mass of 172.5 GeV, in agreement with themore » prediction of the standard model.« less

Flexible Adaptive Paradigms for fMRI Using a Novel Software Package ‘Brain Analysis in Real-Time’ (BART)

PubMed Central

Hellrung, Lydia; Hollmann, Maurice; Zscheyge, Oliver; Schlumm, Torsten; Kalberlah, Christian; Roggenhofer, Elisabeth; Okon-Singer, Hadas; Villringer, Arno; Horstmann, Annette

2015-01-01

In this work we present a new open source software package offering a unified framework for the real-time adaptation of fMRI stimulation procedures. The software provides a straightforward setup and highly flexible approach to adapt fMRI paradigms while the experiment is running. The general framework comprises the inclusion of parameters from subject’s compliance, such as directing gaze to visually presented stimuli and physiological fluctuations, like blood pressure or pulse. Additionally, this approach yields possibilities to investigate complex scientific questions, for example the influence of EEG rhythms or fMRI signals results themselves. To prove the concept of this approach, we used our software in a usability example for an fMRI experiment where the presentation of emotional pictures was dependent on the subject’s gaze position. This can have a significant impact on the results. So far, if this is taken into account during fMRI data analysis, it is commonly done by the post-hoc removal of erroneous trials. Here, we propose an a priori adaptation of the paradigm during the experiment’s runtime. Our fMRI findings clearly show the benefits of an adapted paradigm in terms of statistical power and higher effect sizes in emotion-related brain regions. This can be of special interest for all experiments with low statistical power due to a limited number of subjects, a limited amount of time, costs or available data to analyze, as is the case with real-time fMRI. PMID:25837719

Programs to improve adolescent sexual and reproductive health in the US: a review of the evidence

PubMed Central

Manlove, Jennifer; Fish, Heather; Moore, Kristin Anderson

2015-01-01

Background US adolescents have high rates of teen pregnancy, childbearing, and sexually transmitted infections (STIs), highlighting the need to identify and implement effective programs that will help improve teen sexual and reproductive health. Materials and methods This review identified 103 random-assignment evaluations of 85 programs that incorporated intent-to-treat analyses and assessed impacts on pregnancy, childbearing, STIs, and their key determinants – sexual activity, number of sexual partners, condom use, and other contraceptive use – among teens. This review describes the evidence base for five broad program approaches, including abstinence education, comprehensive sex education, clinic-based programs, youth development programs, and parent–youth relationship programs. We also describe programs with impacts on key outcomes, including pregnancy/childbearing, STIs, and those that found impacts on both sexual activity and contraceptive use. Results Our review identified 52 effective programs: 38 with consistent impacts on reproductive health outcomes, and 14 with mixed findings (across subpopulations, follow-ups, or multiple measures of a single outcome). We found that a variety of program approaches produced impacts on sexual and reproductive health outcomes. Parent–youth relationship programs and clinic-based program evaluations more frequently showed impacts than other program approaches, although we also identified a number of abstinence-education, comprehensive sex education, and youth-development programs with impacts on sexual and reproductive health outcomes. Overall, we identified nine program evaluations with impacts on teen pregnancies or births, five with impacts on reducing STIs, and 15 with impacts on both delaying/reducing sexual activity and increasing contraceptive use (including condom use). Conclusion Future efforts should conduct replications of existing program evaluations, identify implementation components linked to impacts, rigorously evaluate programs that appear promising, and expand the evidence base on programs that impact hormonal and long-acting contraceptive method use. PMID:25897271

75 FR 49432 - Impact Aid Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-13

... CONTACT. Background The Impact Aid Discretionary Construction Program is authorized under section 8007(b... 2004, when the most recent Impact Aid Discretionary Construction Program regulations were issued, the... Federal Domestic Assistance Number 84.041 Impact Aid Discretionary Construction Program) List of Subjects...

Utilization-focused evaluation of a STEM enrichment program

NASA Astrophysics Data System (ADS)

Carter, Sally

The purpose of this study was to determine the impact and utilization of a STEM enrichment program (hereafter referred to as The Program). The Program consisted of two parts. First an educator resource center provided free educational materials throughout The Program’s home state. The second part of The Program was a network of education specialists who provided professional development for teachers, modeled lessons with students, and provided presentations for the general public. The problem addressed by this study was a lack of knowledge regarding the impact of The Program. The Program’s director requested a utilization-focused program evaluation to answer thirteen questions. Questions covered Program impact for five areas: overall impact on teachers, overall impact on students, overall impact of materials, overall impact of Program personnel, and overall impact on STEM education. A mixed-methods case study was designed to gather data. Quantitative data included Program archival data regarding the number of contacts and a survey distributed to teachers who had used The Program’s services on at least one occasion. Qualitative data included written comments gathered from the teacher surveys, seven teacher focus groups, and four Program personnel interviews. Data found an overall positive Program impact in all five areas. Both quantitative and qualitative data showed favorable perceptions by teachers and Program personnel. It is not known if data from this case study can be generalized to other STEM enrichment programs. Future research might include a study to determine if The Program’s model could be used to generate new STEM enrichment programs.

Probing the Higgs self coupling via single Higgs production at the LHC

DOE PAGES

Degrassi, G.; Giardino, P. P.; Maltoni, F.; ...

2016-12-16

Here, we propose a method to determine the trilinear Higgs self coupling that is alternative to the direct measurement of Higgs pair production total cross sections and differential distributions. Furthermore, the method relies on the effects that electroweak loops featuring an anomalous trilinear coupling would imprint on single Higgs production at the LHC. We first calculate these contributions to all the phenomenologically relevant Higgs production (ggF, VBF, WH, ZH, tmore » $$\\bar{t}$$ ) and decay (γγ,WW*/ZZ*→ 4f, b$$\\bar{b}$$,ττ) modes at the LHC and then estimate the sensitivity to the trilinear coupling via a one-parameter fit to the single Higgs measurements at the LHC 8 TeV. We also found that the bounds on the self coupling are already competitive with those from Higgs pair production and will be further improved in the current and next LHC runs.« less

Search for $$\\mathrm{ t \\bar{t} }$$ resonances in highly-boosted lepton+jets and fully hadronic final states in proton-proton collisions at $$ \\sqrt{s} = $$ 13 TeV

DOE PAGES

Sirunyan, Albert M.

2017-07-03

Here, a search for the production of heavy resonances decaying into top quark-antiquark pairs is presented. The analysis is performed in the lepton+jets and fully hadronic channels using data collected in proton-proton collisions at √s =13 TeV using the CMS detector at the LHC, corresponding to an integrated luminosity of 2.6 fb –1. The selection is optimized for massive resonances, where the top quarks have large Lorentz boosts. No evidence for resonant ttbar production is found in the data, and upper limits on the production cross section of heavy resonances are set. The exclusion limits for resonances with masses abovemore » 2 TeV are significantly improved compared to those of previous analyses at √s = 8 TeV.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kozminski, Joseph Francis

The first measurement of the top-antitop production cross section in proton-antiproton collisions at √s = 1.96 TeV using 243 pb -1 of data collected with the D0 detector at Fermilab is presented. In this analysis, only the dielectron final state is considered. Five events are observed, and 0.93 background events are expected. The measured cross section, after accounting for the expected branching ratio to the dielectron channel, is σ tmore » $$\\bar{t}$$ = 14.9$$+9.4\\atop{-7.0}$$(stat)$$+2.5\\atop{-1.8}$${sup +2.5}(syst) ± 1.0 (lumi) pb, which agrees with the predicted cross section for top quarks with a mass of 175 GeV. In addition, a first-pass at a measurement of the top mass using the neutrino-weighting method is presented. This measurement is also performed in the dielectron channel using the five events observed in the cross section measurement.« less

Strong circumstantial proofs about the intermediate polar nature of the cataclysmic variable SS Cygni

NASA Astrophysics Data System (ADS)

Giovannelli, Franco; Sabau-Graziati, Lola

This paper is the updated version of that published in the proceedings of the Integral/Bart Workshop 2011 (Giovannelli & Sabau-Graziati, 2012a). SS Cyg is a cataclysmic variable usually classified as dwarf nova, a subclass of the non-magnetic cataclysmic variables. The goal of this paper is to demonstrate -- on the basis of the many arguments and circumstantial proofs derived from the numerous multifrequency data obtained from the SS Cyg binary system -- that such classification is wrong and that the intermediate polar nature of SS Cyg is the most probable. We derive the magnetic field intensity at the surface of the white dwarf in SS Cyg as B ≃ 1.6 ± 0.7 MG. This value is in complete agreement with the evaluation made by Fabbiano et al. (1981) (B< 1.9 MG) using simultaneous X-ray, UV, and optical data.

Measurement of the charge asymmetry in dileptonic decays of top quark pairs in pp collisions at $$ \\sqrt{s}=7 $$ TeV using the ATLAS detector

DOE PAGES

Aad, G.; Abbott, B.; Abdallah, J.; ...

2015-05-12

A measurement of the top-antitop (tmore » $$\\bar{t}$$) charge asymmetry is presented using data corresponding to an integrated luminosity of 4.6 fb -1 of LHC pp collisions at a centreof-mass energy of 7 TeV collected by the ATLAS detector. Events with two charged leptons, at least two jets and large missing transverse momentum are selected. Two observables are studied: A C ℓℓ based on the identified charged leptons, and A$$t\\bar{t}\\atop{C}$$, based on the reconstructed tt final state. The asymmetries are measured to be A $$ℓℓ\\atop{C}$$ =0.024 ± 0.015 (stat.) ± 0.009 (syst.), A $$t\\bar{t}\\atop{C}$$ = 0.021 ± 0.025 (stat.) ± 0.017 (syst.). The measured values are in agreement with the Standard Model predictions.« less

Mutagenesis and Genome Engineering of Epstein-Barr Virus in Cultured Human Cells by CRISPR/Cas9.

PubMed

Yuen, Kit-San; Chan, Chi-Ping; Kok, Kin-Hang; Jin, Dong-Yan

2017-01-01

The clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9 nuclease (Cas9) system is a powerful genome-editing tool for both chromosomal and extrachromosomal DNA. DNA viruses such as Epstein-Barr virus (EBV), which undergoes episomal replication in human cells, can be effectively edited by CRISPR/Cas9. We have demonstrated targeted editing of the EBV genome by CRISPR/Cas9 in several lines of EBV-infected cells. CRISPR/Cas9-based mutagenesis and genome engineering of EBV provides a new method for genetic analysis, which has some advantages over bacterial artificial chromosome-based recombineering. This approach might also prove useful in the cure of EBV infection. In this chapter, we use the knockout of the BART promoter as an example to detail the experimental procedures for construction of recombinant EBV in human cells.

77 FR 27162 - Notice of Data Availability Supporting Approval and Promulgation of Air Quality Implementation...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-09

...EPA proposed on April 25, 2012 (77 FR 24794) to take action on a revision to the state implementation plan (SIP) addressing regional haze submitted by the State of New York. In that proposal, EPA proposed to address through a Federal Implementation Plan (FIP) certain requirements not addressed in New York's regional haze SIP submission or, alternatively, to approve a substantively identical SIP revision by New York, should the State timely submit such a revision. In two letters dated April 16, 2012, New York submitted additional materials relevant to our proposed action on its regional haze SIP submission, including proposed SIP revisions addressing the requirements for best available retrofit technology controls (BART) for a number of sources. EPA is providing notice of availability of these materials. The comment period on EPA's proposed action on the New York regional haze SIP closes on June 18, 2010.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Degrassi, G.; Giardino, P. P.; Maltoni, F.

Here, we propose a method to determine the trilinear Higgs self coupling that is alternative to the direct measurement of Higgs pair production total cross sections and differential distributions. Furthermore, the method relies on the effects that electroweak loops featuring an anomalous trilinear coupling would imprint on single Higgs production at the LHC. We first calculate these contributions to all the phenomenologically relevant Higgs production (ggF, VBF, WH, ZH, tmore » $$\\bar{t}$$ ) and decay (γγ,WW*/ZZ*→ 4f, b$$\\bar{b}$$,ττ) modes at the LHC and then estimate the sensitivity to the trilinear coupling via a one-parameter fit to the single Higgs measurements at the LHC 8 TeV. We also found that the bounds on the self coupling are already competitive with those from Higgs pair production and will be further improved in the current and next LHC runs.« less

KSC-2009-3842

NASA Image and Video Library

2009-06-25

CAPE CANAVERAL, Fla. – Bart Hagemeyer, at left, meteorologist in charge, NOAA National Weather Service forecast office, Melbourne, Fla., and Joel Tumbiolo, Delta IV launch weather officer, 45th Weather Squadron, Cape Canaveral Air Force Station, participate in a prelaunch news conference on the Geostationary Operational Environmental Satellite-O mission in NASA's Kennedy Space Center press site auditorium. The GOES-O satellite is targeted to launch June 26. The latest Geostationary Operational Environmental Satellite, GOES-O was developed by NASA for the National Oceanic and Atmospheric Administration, or NOAA. Each of the GOES satellites continuously provides observations of 60 percent of the Earth including the continental United States, providing weather monitoring and forecast operations as well as a continuous and reliable stream of environmental information and severe weather warnings. Once in orbit, GOES-O will be designated GOES-14, and NASA will provide on-orbit checkout and then transfer operational responsibility to NOAA. Photo credit: NASA/Jim Grossmann

Next-to-leading order QCD predictions for top-quark pair production with up to three jets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Höche, S.; Maierhöfer, P.; Moretti, N.

2017-03-07

Here, we present theoretical predictions for the production of top-quark pairs with up to three jets at the next-to leading order in perturbative QCD. The relevant calculations are performed with Sherpa and OpenLoops. In order to address the issue of scale choices and related uncertainties in the presence of multiple scales, we compare results obtained with the standard scale HT/2HT/2 at fixed order and the MiNLO procedure. By analyzing various cross sections and distributions for tmore » $$\\bar{t}$$+0,1,2,3 jets at the 13 TeV LHC we found a remarkable overall agreement between fixed-order and MiNLO results. The differences are typically below the respective factor-two scale variations, suggesting that for all considered jet multiplicities missing higher-order effects should not exceed the ten percent level.« less

A measurement of t$$\\bar{t}$$ production cross section in p$$\\bar{p}$$ collisions at √s = 1.8 TeV using neural networks

DOE Office of Scientific and Technical Information (OSTI.GOV)

Singh, Harpreet

The authors present the results of a new measurement of the tmore » $$\\bar{t}$$ production cross section using eμ channel in p$$\\bar{p}$$ collisions at √s = 1.8 TeV. This study corresponds to an integrated luminosity of 108.3 ± 5.7 pb -1 acquired by the D0 detector during the Fermilab Tevatron Collider Run 1 (1992--1996). By using neural network techniques instead of the conventional analysis methods, the authors show that the signal acceptance can be increased by 10% (for m t = 172 GeV/c 2) while the background remains constant. Four eμ events are observed in data with an estimated background of 0.22 ± 0.14 corresponding to a t$$\\bar{t}$$ production cross section of 9.75 ± 5.53 pb.« less

Risky decision-making is associated with residential choice in healthy older adults.

PubMed

Seaman, Kendra L; Stillman, Chelsea M; Howard, Darlene V; Howard, James H

2015-01-01

As our society becomes more mobile and people reside farther away from their immediate families, competent decision-making has become critical for the older adults wishing to maintain their independence. However, very little is known about the relationship between residential choice and decision-making. Here we use the Balloon Analog Risk Task (BART) to examine risk-taking in two samples of older adults, one living in a retirement community and another living independently. We also used a cognitive model to gain insight into the cognitive factors underlying decision-making in these groups. We found that older adults living in a retirement community were more risk averse than their independent counterparts. Furthermore, this difference appeared to be motivated by group differences in initial perception of risk. This study suggests an intriguing difference between these two residential groups, and also points to the utility of using laboratory methods in research on real-world problems.

Using program impact pathways to understand and improve program delivery, utilization, and potential for impact of Helen Keller International's homestead food production program in Cambodia.

PubMed

Olney, Deanna K; Vicheka, Sao; Kro, Meng; Chakriya, Chhom; Kroeun, Hou; Hoing, Ly Sok; Talukder, Aminzzaman; Quinn, Victoria; Iannotti, Lora; Becker, Elisabeth; Roopnaraine, Terry

2013-06-01

Evidence of the impact of homestead food production programs on nutrition outcomes such as anemia and growth is scant. In the absence of information on program impact pathways, it is difficult to understand why these programs, which have been successful in increasing intake of micronutrient-rich foods, have had such limited documented impact on nutrition outcomes. To conduct a process evaluation of Helen Keller International's (HKI's) homestead food production program in Cambodia to assess whether the program was operating as planned (in terms of design, delivery, and utilization) and to identify ways in which the program might need to be strengthened in order to increase its potential for impact. A program theory framework, which laid out the primary components along the hypothesized program impact pathways, was developed in collaboration with HKI and used to design the research. Semistructured interviews and focus group discussions with program beneficiaries (n = 36 and 12, respectively), nonbeneficiaries (n = 12), and program implementers (n = 17 and 2, respectively) and observations of key program delivery points, including health and nutrition training sessions (n = 6), village model farms (n = 6), and household gardens of beneficiaries (n = 36) and nonbeneficiaries (n = 12), were conducted to assess the delivery and utilization of the primary program components along the impact pathways. The majority of program components were being delivered and utilized as planned. However, challenges with some of the key components posited to improve outcomes such as anemia and growth were noted. Among these were a gap in the expected pathway from poultry production to increased intake of eggs and poultry meat, and some weaknesses in the delivery of the health and nutrition training sessions and related improvements in knowledge among the village health volunteers and beneficiaries. Although the program has been successful in delivering the majority of the program components as planned and has documented achievements in improving household production and intake of micronutrient-rich foods, it is likely that strengthening delivery and increasing utilization of some program components would increase its potential for nutritional impacts. This research has highlighted the importance of designing a program theory framework and assessing the components that lie along the primary program impact pathways to optimize program service delivery and utilization and, in turn, potential for impact.

A Change Impact Analysis to Characterize Evolving Program Behaviors

NASA Technical Reports Server (NTRS)

Rungta, Neha Shyam; Person, Suzette; Branchaud, Joshua

2012-01-01

Change impact analysis techniques estimate the potential effects of changes made to software. Directed Incremental Symbolic Execution (DiSE) is an intraprocedural technique for characterizing the impact of software changes on program behaviors. DiSE first estimates the impact of the changes on the source code using program slicing techniques, and then uses the impact sets to guide symbolic execution to generate path conditions that characterize impacted program behaviors. DiSE, however, cannot reason about the flow of impact between methods and will fail to generate path conditions for certain impacted program behaviors. In this work, we present iDiSE, an extension to DiSE that performs an interprocedural analysis. iDiSE combines static and dynamic calling context information to efficiently generate impacted program behaviors across calling contexts. Information about impacted program behaviors is useful for testing, verification, and debugging of evolving programs. We present a case-study of our implementation of the iDiSE algorithm to demonstrate its efficiency at computing impacted program behaviors. Traditional notions of coverage are insufficient for characterizing the testing efforts used to validate evolving program behaviors because they do not take into account the impact of changes to the code. In this work we present novel definitions of impacted coverage metrics that are useful for evaluating the testing effort required to test evolving programs. We then describe how the notions of impacted coverage can be used to configure techniques such as DiSE and iDiSE in order to support regression testing related tasks. We also discuss how DiSE and iDiSE can be configured for debugging finding the root cause of errors introduced by changes made to the code. In our empirical evaluation we demonstrate that the configurations of DiSE and iDiSE can be used to support various software maintenance tasks

The Value in Evaluating and Communicating Program Impact: The Ohio BR&E Program

ERIC Educational Resources Information Center

Daivs, Gregory

2012-01-01

Assessing program impact can provide useful program evaluation data. It also provides a basis for program development, marketing, and justification. This article discusses recent impact evaluation efforts and findings of a long-time Extension program; referred to as Business Retention and Expansion (BR&E). How such information can be…

The Implications of 3D Thermal Structure on 1D Atmospheric Retrieval

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blecic, Jasmina; Dobbs-Dixon, Ian; Greene, Thomas, E-mail: jasmina@nyu.edu

Using the atmospheric structure from a 3D global radiation-hydrodynamic simulation of HD 189733b and the open-source Bayesian Atmospheric Radiative Transfer (BART) code, we investigate the difference between the secondary-eclipse temperature structure produced with a 3D simulation and the best-fit 1D retrieved model. Synthetic data are generated by integrating the 3D models over the Spitzer , the Hubble Space Telescope ( HST ), and the James Web Space Telescope ( JWST ) bandpasses, covering the wavelength range between 1 and 11 μ m where most spectroscopically active species have pronounced features. Using the data from different observing instruments, we present detailedmore » comparisons between the temperature–pressure profiles recovered by BART and those from the 3D simulations. We calculate several averages of the 3D thermal structure and explore which particular thermal profile matches the retrieved temperature structure. We implement two temperature parameterizations that are commonly used in retrieval to investigate different thermal profile shapes. To assess which part of the thermal structure is best constrained by the data, we generate contribution functions for our theoretical model and each of our retrieved models. Our conclusions are strongly affected by the spectral resolution of the instruments included, their wavelength coverage, and the number of data points combined. We also see some limitations in each of the temperature parametrizations, as they are not able to fully match the complex curvatures that are usually produced in hydrodynamic simulations. The results show that our 1D retrieval is recovering a temperature and pressure profile that most closely matches the arithmetic average of the 3D thermal structure. When we use a higher resolution, more data points, and a parametrized temperature profile that allows more flexibility in the middle part of the atmosphere, we find a better match between the retrieved temperature and pressure profile and the arithmetic average. The Spitzer and HST simulated observations sample deep parts of the planetary atmosphere and provide fewer constraints on the temperature and pressure profile, while the JWST observations sample the middle part of the atmosphere, providing a good match with the middle and most complex part of the arithmetic average of the 3D temperature structure.« less

Are You Making an Impact? Evaluating the Population Health Impact of Community Benefit Programs.

PubMed

Rains, Catherine M; Todd, Greta; Kozma, Nicole; Goodman, Melody S

The Patient Protection and Affordable Care Act includes a change to the IRS 990 Schedule H, requiring nonprofit hospitals to submit a community health needs assessment every 3 years. Such health care entities are challenged to evaluate the effectiveness of community benefit programs addressing the health needs identified. In an effort to determine the population health impact of community benefit programs in 1 hospital outreach department, researchers and staff conducted an impact evaluation to develop priority areas and overarching goals along with program- and department-level objectives. The longitudinal impact evaluation study design consists of retrospective and prospective secondary data analyses. As an urban pediatric hospital, St Louis Children's Hospital provides an array of community benefit programs to the surrounding community. Hospital staff and researchers came together to form an evaluation team. Data from program evaluation and administrative data for analysis were provided by hospital staff. Impact scores were calculated by scoring objectives as met or unmet and averaged across goals to create impact scores that measure how closely programs meet the overarching departmental mission and goals. Over the 4-year period, there is an increasing trend in program-specific impact scores across all programs except one, Healthy Kids Express Asthma, which had a slight decrease in year 4 only. Current work in measuring and assessing the population health impact of community benefit programs is mostly focused on quantifying dollars invested into community benefit work rather than measuring the quality and impact of services. This article provides a methodology for measuring population health impact of community benefit programs that can be used to evaluate the effort of hospitals in providing community benefit. This is particularly relevant in our changing health care climate, as hospitals are being asked to justify community benefit and make meaningful contributions to population health. The Patient Protection and Affordable Care Act includes a change to the IRS 990 Schedule H, requiring nonprofit hospitals to submit a community health needs assessment every 3 years, and requires evaluation of program effectiveness; yet, it does not require any quantification of the impact of community benefit programs. The IRS Schedule H 990 policies could be strengthened by requiring an impact evaluation such as outlined in this article. As hospitals are being asked to justify community benefit and make meaningful contributions to population health, impact evaluations can be utilized to demonstrate the cumulative community benefit of programs and assess population health impact of community benefit programs.

Perceptions of self-defined memory problems vary in south Asian minority older people who consult a GP and those who do not: a mixed-method pilot study.

PubMed

Giebel, Clarissa; Challis, David; Worden, Angela; Jolley, David; Bhui, Kamaldeep Singh; Lambat, Ahmed; Purandare, Nitin

2016-04-01

South Asian older adults access services for mental health problems and dementia less than other older people in the UK, unlike for physical health problems. This pilot study investigated how South Asians with self-defined memory problems, with and without GP consultation, construe the symptoms, causes, consequences and treatment of the condition. Participants were recruited through community centres, their networks and memory clinics in Greater Manchester. The newly developed Barts Explanatory Model Inventory for Dementia (BEMI-D) was administered to 33 (18 M, 15 F) older South Asians aged 65 or above with memory problems in English, Gujarati or Urdu. Furthermore, cognition, executive function and depression were assessed. Perceptions of dementia varied by GP consultation for memory problems. A greater proportion of older adults without a consultation considered memory problems to be given by God, saw acceptance of fate as an alternative treatment and did not identify medical support as appropriate. Forgetfulness and loss of social meaning were identified as symptoms of dementia more by those with a consultation. Higher levels of diabetes, heart disease and depression were found in those without a consultation. Differences in perceptions may influence the decision about consulting a GP. Similarly, consultation for memory problems appears linked to extent physical health problems and mental health consultation (depression). These variations reported on a small scale in this pilot study suggest the need to explore the impact of perceptions on rates of GP consultation, so as to improve timely diagnosis and access to appropriate services. Copyright © 2015 John Wiley & Sons, Ltd.

The influence of groups and alcohol consumption on individual risk-taking.

PubMed

Erskine-Shaw, Marianne; Monk, Rebecca L; Qureshi, Adam W; Heim, Derek

2017-10-01

Research addressing the influence of alcohol and groups on risky behaviour has yielded contradictory findings regarding the extent to which intoxicated groups exaggerate or minimise risk-taking. Previous work has examined the effect of intoxication on risk-taking focusing on collective group decision-making, and to date the influence of alcohol consumption and groups on individual risk-taking has yet to be explored experimentally. The current study therefore examined the impact of intoxication and groups on individual risk-taking. In a mixed design, 99 social drinkers (62 female) attended an experimental session individually (N=48) or in groups of three (N=51). Individuals completed the study in isolation while groups were tested in the same room. Participants completed two behavioural measures of risk-taking: Balloon Analogue Risk Task (BART) and Stoplight Task (SLT), both before and following consumption of an alcoholic (0.6g/kg males, 0.5g/kg females) or a placebo beverage. Those who participated in groups took significantly more risks in both tasks than those in isolation. Alcohol did not increase risk-taking on either risk-taking tasks. However, those who consumed placebo were significantly less risky on the SLT, compared to baseline. No interactions were found between context and beverage on risk-taking. The findings do not support a combined effect of alcohol and groups on individual risk-taking. Rather, results indicate that risk-taking behaviour is influenced by peer presence regardless of alcohol consumption. Targeting the influence of groups (above those of alcohol) may hold promise for reducing risk-taking behaviours in drinking environments. Copyright © 2017 Elsevier B.V. All rights reserved.

Future Earth: Reducing Loss By Automating Response to Earthquake Shaking

NASA Astrophysics Data System (ADS)

Allen, R. M.

2014-12-01

Earthquakes pose a significant threat to society in the U.S. and around the world. The risk is easily forgotten given the infrequent recurrence of major damaging events, yet the likelihood of a major earthquake in California in the next 30 years is greater than 99%. As our societal infrastructure becomes ever more interconnected, the potential impacts of these future events are difficult to predict. Yet, the same inter-connected infrastructure also allows us to rapidly detect earthquakes as they begin, and provide seconds, tens or seconds, or a few minutes warning. A demonstration earthquake early warning system is now operating in California and is being expanded to the west coast (www.ShakeAlert.org). In recent earthquakes in the Los Angeles region, alerts were generated that could have provided warning to the vast majority of Los Angelinos who experienced the shaking. Efforts are underway to build a public system. Smartphone technology will be used not only to issue that alerts, but could also be used to collect data, and improve the warnings. The MyShake project at UC Berkeley is currently testing an app that attempts to turn millions of smartphones into earthquake-detectors. As our development of the technology continues, we can anticipate ever-more automated response to earthquake alerts. Already, the BART system in the San Francisco Bay Area automatically stops trains based on the alerts. In the future, elevators will stop, machinery will pause, hazardous materials will be isolated, and self-driving cars will pull-over to the side of the road. In this presentation we will review the current status of the earthquake early warning system in the US. We will illustrate how smartphones can contribute to the system. Finally, we will review applications of the information to reduce future losses.

Wing Leading Edge RCC Rapid Response Damage Prediction Tool (IMPACT2)

NASA Technical Reports Server (NTRS)

Clark, Robert; Cottter, Paul; Michalopoulos, Constantine

2013-01-01

This rapid response computer program predicts Orbiter Wing Leading Edge (WLE) damage caused by ice or foam impact during a Space Shuttle launch (Program "IMPACT2"). The program was developed after the Columbia accident in order to assess quickly WLE damage due to ice, foam, or metal impact (if any) during a Shuttle launch. IMPACT2 simulates an impact event in a few minutes for foam impactors, and in seconds for ice and metal impactors. The damage criterion is derived from results obtained from one sophisticated commercial program, which requires hours to carry out simulations of the same impact events. The program was designed to run much faster than the commercial program with prediction of projectile threshold velocities within 10 to 15% of commercial-program values. The mathematical model involves coupling of Orbiter wing normal modes of vibration to nonlinear or linear springmass models. IMPACT2 solves nonlinear or linear impact problems using classical normal modes of vibration of a target, and nonlinear/ linear time-domain equations for the projectile. Impact loads and stresses developed in the target are computed as functions of time. This model is novel because of its speed of execution. A typical model of foam, or other projectile characterized by material nonlinearities, impacting an RCC panel is executed in minutes instead of hours needed by the commercial programs. Target damage due to impact can be assessed quickly, provided that target vibration modes and allowable stress are known.

A preliminary study of longitudinal neuroadaptation associated with recovery from addiction.

PubMed

Forster, Sarah E; Finn, Peter R; Brown, Joshua W

2016-11-01

Few studies have explored longitudinal change in event-related brain responses during early recovery from addiction. Moreover, existing findings yield evidence of both increased and decreased signaling within reward and control centers over time. The current study explored reward- and control-related signals in a risky decision-making task and specifically investigated parametric modulations of the BOLD signal, rather than signal magnitude alone. It was hypothesized that risk-related signals during decision-making and outcome evaluation would reflect recovery and that change in specific signals would correspond with improved treatment outcomes. Twenty-one substance dependent individuals were recruited upon enrollment in community-based substance use treatment programs, wherein they received treatment-as-usual. Participants completed functional neuroimaging assessments at baseline and 3-month follow-up while performing the Balloon Analogue Risk Task (BART). Risk- and reward-sensitive signals were identified using parametric modulators. Substance use was tracked throughout the 3-month study interval using the timeline follow-back procedure. Longitudinal contrasts of parametric modulators suggested improved formation of risk-informed outcome expectations at follow-up. Specifically, a greater response to high risk (low-likelihood) positive feedback was identified in caudal anterior cingulate cortex (ACC) and a greater response to low risk (low-likelihood) negative feedback was identified in caudal ACC and inferior frontal gyrus. In addition, attenuation of a ventromedial prefrontal cortex (vmPFC) "reward-seeking" signal (i.e., increasing response with greater reward) during risky decisions at follow-up was associated with less substance use during the study interval. Changes in risk- and reward-related signaling in ACC/vmPFC appear to reflect recovery and may support sobriety. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

A Comparison of BLISS and PLD on Low-SNR WASP-29b Spitzer Observations

NASA Astrophysics Data System (ADS)

Challener, Ryan; Harrington, Joseph; Cubillos, Patricio E.; Blecic, Jasmina; Deming, Drake; Hellier, Coel

2018-01-01

We present an analysis of Spitzer secondary eclipse observations of exoplanet WASP-29b. WASP-29b is a Saturn-sized, short-period exoplanet with mass 0.24 ± 0.02 Jupiter masses and radius 0.84 ± 0.06 Jupiter radii (Hellier et al., 2010). We measure eclipse depths and midpoints using our Photometry for Orbits, Eclipses, and Transits (POET) code, which does photometry and light-curve modeling with a BiLinearly Interpolated Subpixel Sensitivity (BLISS) map, and our Zen Eliminates Noise (ZEN) code, which takes POET photometry and applies Pixel-Level Decorrelation (PLD). BLISS creates a physical map of pixel gain variations, and is thereby independent of any astrophysical effects. PLD takes a mathematical approach, using relative variations in pixel values near the target to eliminate position-correlated noise. The results are consistent between the methods, except in one outlier observation where neither model could effectively remove correlated noise in the light curve. Using the eclipse timings, along with previous transit observations and radial velocity data, we further refine the orbit of WASP-29b, and, when excluding the outlier, determine an eccentricity between 0.037 and 0.056. We performed atmospheric retrieval with our Bayesian Atmospheric Radiative Transfer (BART) code but find that, when the outlier is discarded, the planet is consistent with a blackbody, and molecular abundances cannot be constrained. This work is based on observations made with the Spitzer Space Telescope, which is operated by the Jet Propulsion Laboratory, California Institute of Technology under a contract with NASA. This work was supported by NASA Planetary Atmospheres grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G.

Factor Analysis of the HEW National Strategy for Youth Development Model's Community Program Impact Scales.

ERIC Educational Resources Information Center

Truckenmiller, James L.

The former HEW (Health, Education, and Welfare) National Strategy for Youth Development Model proposed a community-based program to promote positive youth development and to prevent delinquency through a sequence of youth needs assessments, needs-targeted programs, and program impact evaluation. HEW Community Program Impact Scales data obtained…

45 CFR 284.30 - What information must the State include in its assessment of the impact of the TANF program(s) in...

Code of Federal Regulations, 2014 CFR

2014-10-01

... assessment of the impact of the TANF program(s) in the State on the increase in child poverty? 284.30 Section... TANF PROGRAM § 284.30 What information must the State include in its assessment of the impact of the... PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES METHODOLOGY...

45 CFR 284.30 - What information must the State include in its assessment of the impact of the TANF program(s) in...

Code of Federal Regulations, 2012 CFR

2012-10-01

... assessment of the impact of the TANF program(s) in the State on the increase in child poverty? 284.30 Section... TANF PROGRAM § 284.30 What information must the State include in its assessment of the impact of the... PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES METHODOLOGY...

45 CFR 284.30 - What information must the State include in its assessment of the impact of the TANF program(s) in...

Code of Federal Regulations, 2013 CFR

2013-10-01

... assessment of the impact of the TANF program(s) in the State on the increase in child poverty? 284.30 Section... TANF PROGRAM § 284.30 What information must the State include in its assessment of the impact of the... PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES METHODOLOGY...

45 CFR 284.30 - What information must the State include in its assessment of the impact of the TANF program(s) in...

Code of Federal Regulations, 2011 CFR

2011-10-01

... assessment of the impact of the TANF program(s) in the State on the increase in child poverty? 284.30 Section... TANF PROGRAM § 284.30 What information must the State include in its assessment of the impact of the... PROGRAMS), ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES METHODOLOGY...

Driving social impact with common global indicators for healthy lifestyle programs: lessons learned.

PubMed

Robinson, Nicole R; Gin, Julia; Kamath-Jha, Shilpa; Infantes, Michel; Hernandez, Ricardo; Alberg-Seberich, Michael; Suri, Devika; Pérez-Escamilla, Rafael

2014-09-01

Partnerships between corporate entities and non-governmental organizations (NGOs) involved in delivering community focused health and well-being programs are becoming increasingly valuable especially in the context of promoting healthy lifestyles around the globe. The Mondelēz International Foundation (MIF) has funded healthy lifestyles community based programs targeting children and youth through partnership with seven global NGOs. To assess collective impact of these programs, it is crucial to identify best practices and common impact indicators that can be measured across programs. MIF therefore organized the Healthy Lifestyles Evaluation Workshop to explore these pertinent questions. Share best practices and identify common impact indicators to measure the success of current and future MIF funded healthy lifestyles programs. Analysis of the Program Impact Pathways (PIPs) and measured output of each of the seven programs. Individual and combined analysis of PIPs of the seven NGO programs led to identification of three critical impact indicators: nutrition knowledge, physical activity, and healthier eating, and also enabled NGOs to identify pathways to improve program delivery among the target population. This workshop enabled MIF and partner NGOs to came together to align on metrics and future engagement approaches for promoting and evaluating community based healthy lifestyles programs.

Toward an Inventory of Federal Programs with Direct Impact on Families: Staff Report - Family Impact Seminar, February 1978.

ERIC Educational Resources Information Center

George Washington Univ., Washington, DC. Inst. for Educational Leadership.

This report presents an inventory of 268 federal programs which have direct impact on families, selected from the 1,044 programs listed in the Catalog of Federal Domestic Assistance for fiscal year 1976. Introductory sections describe the background of the inventory and explain the definitions and concepts (family, impact, direct impact, and…

76 FR 27363 - Proposed Information Collection Request (ICR) for the Impact Evaluation of the YouthBuild Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... characteristics? What are YouthBuild's impacts on crime and delinquency? What are the program's impacts on social... (ICR) for the Impact Evaluation of the YouthBuild Program; Comment Request AGENCY: Employment and..., collection instruments are clearly understood, and [[Page 27364

Navy Ford (CVN-78) Class Aircraft Carrier Program: Background and Issues for Congress

DTIC Science & Technology

2015-12-17

AP funding for the ship. Oversight issues for Congress for the CVN-78 program include the following:  the potential impact on the CVN-78 program...Potential Impact of Continuing Resolution (CR) for FY2016 .................................................. 7 Overview...7 Impact on CVN-78 Program

Socioeconomic impact assessment in ex ante evaluations: a case study on the rural development programs of the European Union.

PubMed

Vidueira, Pablo; Díaz-Puente, José M; Rivera, María

2014-08-01

Ex ante impact assessment has become a fundamental tool for effective program management, and thus, a compulsory task when establishing a new program in the European Union (EU). This article aims to analyze benefits from ex ante impact assessment, methodologies followed, and difficulties encountered. This is done through the case study on the rural development programs (RDPs) in the EU. Results regarding methodologies are then contrasted with the international context in order to provide solid insights to evaluators and program managing authorities facing ex ante impact assessment. All European RDPs from the period 2007 through 2013 (a total of 88) and their corresponding available ex ante evaluations (a total of 70) were analyzed focusing on the socioeconomic impact assessment. Only 46.6% of the regions provide quantified impact estimations on socioeconomic impacts in spite of it being a compulsory task demanded by the European Commission (EC). Recommended methods by the EC are mostly used, but there is a lack of mixed method approaches since qualitative methods are used in substitution of quantitative ones. Two main difficulties argued were the complexity of program impacts and the lack of needed program information. Qualitative approaches on their own have been found as not suitable for ex ante impact assessment, while quantitative approaches-such as microsimulation models-provide a good approximation to actual impacts. However, time and budgetary constraints make that quantitative and mixed methods should be mainly applied on the most relevant impacts for the program success. © The Author(s) 2014.

Evaluating Realized Impacts of DOE/EERE R&D Programs. Standard impact evaluation method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruegg, Rosalie; O'Connor, Alan C.; Loomis, Ross J.

2014-08-01

This document provides guidance for evaluators who conduct impact assessments of research and development (R&D) programs for the U.S. Department of Energy’s (DOE) Office of Energy Efficiency and Renewable Energy (EERE). It is also targeted at EERE program staff responsible for initiating and managing commissioned impact studies. The guide specifies how to estimate economic benefits and costs, energy saved and installed or generated, environmental impacts, energy security impacts, and knowledge impacts of R&D investments in advanced energy technologies.

76 FR 68219 - Agency Information Collection Activities; Submission for OMB Review; Comment Request; Impact...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-03

... for OMB Review; Comment Request; Impact Evaluation of the YouthBuild Program ACTION: Notice. SUMMARY... proposal for a new information collection titled, ``Impact Evaluation of the YouthBuild Program,'' to the... support of an impact evaluation of the YouthBuild Program. Specifically, the DOL seeks to conduct a census...

77 FR 6585 - Proposed Information Collection Request (ICR) for the Impact Evaluation of the YouthBuild Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-08

... job characteristics? What are YouthBuild's impacts on crime and delinquency? What are the program's... (ICR) for the Impact Evaluation of the YouthBuild Program; New Collection AGENCY: Employment and... instruments are clearly understood, and the impact of collection requirements on respondents can be properly...

Impact of Pharmacists’ Participation in a Pharmacotherapy Follow-Up Program

PubMed Central

Dualde, Elena; Santonja, Francisco J.; Faus, Maria J.

2012-01-01

Objective. To evaluate the impact of a continuing pharmacy education (CPE) course on Spanish community pharmacists’ participation in a pharmacotherapy follow-up program. Design. Participation in a CPE course offered 4 times over a 4-year period via satellite teleconferencing was monitored and the data analyzed to determine the course’s impact on community pharmacists’ participation in a pharmacotherapy follow-up program. Assessment. Community pharmacists’ participation in the pharmaceutical care CPE course had a slightly positive impact on their participation in the pharmacotherapy follow-up program. In the best profiles, there was a probability of 7.3% that participants would participate in the pharmacotherapy follow-up program. Conclusions. Completion of pharmaceutical care CPE courses did not have a significant impact on pharmacists’ participation in a pharmacotherapy follow-up program. PMID:22438606

Interactive multi-mode blade impact analysis

NASA Technical Reports Server (NTRS)

Alexander, A.; Cornell, R. W.

1978-01-01

The theoretical methodology used in developing an analysis for the response of turbine engine fan blades subjected to soft-body (bird) impacts is reported, and the computer program developed using this methodology as its basis is described. This computer program is an outgrowth of two programs that were previously developed for the purpose of studying problems of a similar nature (a 3-mode beam impact analysis and a multi-mode beam impact analysis). The present program utilizes an improved missile model that is interactively coupled with blade motion which is more consistent with actual observations. It takes into account local deformation at the impact area, blade camber effects, and the spreading of the impacted missile mass on the blade surface. In addition, it accommodates plate-type mode shapes. The analysis capability in this computer program represents a significant improvement in the development of the methodology for evaluating potential fan blade materials and designs with regard to foreign object impact resistance.

Measuring the Impact of Employment-Related Social Programs. A Primer on the Evaluation of Employment and Training, Vocational Education, Vocational Rehabilitation, and Other Job-Oriented Programs.

ERIC Educational Resources Information Center

Borus, Michael E.

An approach and methodology for the systematic measurement of the impact of employment-related social programs is presented in this primer. Chapter 1 focuses on evaluation as the third step (the first two being planning and operation) in the process of program implementation. Chapter 2 examines the impacts of social programs. Topics include…

The Impact of a Campus-Based 4-H Summer Conference Program on Youth Thriving

ERIC Educational Resources Information Center

Arnold, Mary E.; Davis, Jamie M.; Lundeberg, Roberta

2017-01-01

In 2014 the Oregon 4-H program adopted a new program model to describe and evaluate the impact of 4-H on youths. The model is based on promoting thriving in young people, with an emphasis on high program quality. This article discusses the impact on thriving in 378 youth participants of the 4-H Summer Conference (4-HSC) program. The results of the…

From Implementation to Outcomes to Impacts: Designing a Comprehensive Program Evaluation

NASA Astrophysics Data System (ADS)

Shebby, S.

2015-12-01

Funders are often interested in learning about the impact of program activities, yet before the impacts are determined, educational evaluations should first examine program implementation and outcomes. Implementation evaluation examines how and the extent to which program activities are delivered as intended, including the extent to which activities reached the targeted participants. Outcome evaluation is comprised of a systematic examination of the effects that a program has on program participants, such as changes in knowledge, attitudes, beliefs, values, and behaviors. In this presentation, presenters will share insights on evaluating the implementation, outcomes, and impacts associated with an online science curriculum for K-2 students. The science curriculum was designed to provide students with access to science concepts and skills in an interactive and innovative environment, and teachers with embedded, aligned, and on-demand professional development. One of the most important—and challenging—steps in this evaluation was to select outcomes that were well-defined, measurable, and aligned to program activities, as well as relevant to program stakeholders. An additional challenge was to measure implementation given limited access to the classroom environment. This presentation will include a discussion of the process evaluators used to select appropriate implementation indicators and outcomes (teacher and student), design an evaluation approach, and craft data collection instruments. Although examples provided are specific to the K-2 science intervention, the best practices discussed are pertinent to all program and event evaluations. Impact evaluation goes beyond implementation and outcome evaluation to inform whether a program is working or not. It requires a comparison group to inform what outcomes would have been in the absence of the intervention. As such, this presentation will also include a discussion of impacts, including how impacts are defined and measured, and some common challenges in evaluating program impact.

Can We Have It All? A Review of the Impacts of School Choice on Racial Integration

ERIC Educational Resources Information Center

Swanson, Elise

2017-01-01

This article reviews the literature evaluating the impact of school choice programs on racial integration. Evidence on the impacts of magnet schools, voluntary busing programs, open enrollment practices, charter schools, and voucher programs is reviewed. The literature is mixed on this question, finding that the impacts of choice on racial…

The Impact of Spiritual Learning on the Lives of Adults in Postsecondary Martial Arts Educational Programs

ERIC Educational Resources Information Center

Ingram, Jeffrey G.

2017-01-01

This study investigated whether spiritual learning impacts the lives of adult learners in martial arts educational programs. The impact of spirituality has been claimed as a meaningful connection; however, it is not currently known how spiritual learning impacts the lives and experiences of adult learners with these programs. Spiritual learning…

Experiential leadership training for pediatric chief residents: impact on individuals and organizations.

PubMed

Doughty, Robert A; Williams, Patricia D; Brigham, Timothy P; Seashore, Charles

2010-06-01

The past decade has seen a proliferation of leadership training programs for physicians that teach skills outside the graduate medical education curriculum. To determine the perceived value and impact of an experiential leadership training program for pediatric chief residents on the chief residents and on their programs and institutions. The authors conducted a retrospective study. Surveys were sent to chief residents who completed the Chief Resident Training Program (CRTP) between 1988 and 2003 and to their program directors and department chairs asking about the value of the program, its impact on leadership capabilities, as well as the effect of chief resident training on programs and institutions. Ninety-four percent of the chief residents and 94% of program directors and department chairs reported that the CRTP was "very" or "somewhat" relevant, and 92% of the chief residents indicated CRTP had a positive impact on their year as chief resident; and 75% responded it had a positive impact beyond residency. Areas of greatest positive impact included awareness of personality characteristics, ability to manage conflict, giving and receiving feedback, and relationships with others. Fifty-six percent of chief residents reported having held a formal leadership position since chief residency, yet only 28% reported having received additional leadership training. The study demonstrates a perceived positive impact on CRTP participants and their programs and institutions in the short and long term.

A combined impact-process evaluation of a program promoting active transport to school: understanding the factors that shaped program effectiveness.

PubMed

Crawford, S; Garrard, J

2013-01-01

This mixed methods study was a comprehensive impact-process evaluation of the Ride2School program in metropolitan and regional areas in Victoria, Australia. The program aimed to promote transport to school for primary school children. Qualitative and quantitative data were collected at baseline and followup from two primary schools involved in the pilot phase of the program and two matched comparison schools, and a further 13 primary schools that participated in the implementation phase of the program. Classroom surveys, structured and unstructured observations, and interviews with Ride2School program staff were used to evaluate the pilot program. For the 13 schools in the second phase of the program, parents and students completed questionnaires at baseline (N = 889) and followup (N = 761). Based on the quantitative data, there was little evidence of an overall increase in active transport to school across participating schools, although impacts varied among individual schools. Qualitative data in the form of observations, interviews, and focus group discussions with students, school staff, and program staff provided insight into the reasons for variable program impacts. This paper highlights the benefits of undertaking a mixed methods approach to evaluating active transport to school programs that enables both measurement and understanding of program impacts.

A Combined Impact-Process Evaluation of a Program Promoting Active Transport to School: Understanding the Factors That Shaped Program Effectiveness

PubMed Central

Crawford, S.; Garrard, J.

2013-01-01

This mixed methods study was a comprehensive impact-process evaluation of the Ride2School program in metropolitan and regional areas in Victoria, Australia. The program aimed to promote transport to school for primary school children. Qualitative and quantitative data were collected at baseline and followup from two primary schools involved in the pilot phase of the program and two matched comparison schools, and a further 13 primary schools that participated in the implementation phase of the program. Classroom surveys, structured and unstructured observations, and interviews with Ride2School program staff were used to evaluate the pilot program. For the 13 schools in the second phase of the program, parents and students completed questionnaires at baseline (N = 889) and followup (N = 761). Based on the quantitative data, there was little evidence of an overall increase in active transport to school across participating schools, although impacts varied among individual schools. Qualitative data in the form of observations, interviews, and focus group discussions with students, school staff, and program staff provided insight into the reasons for variable program impacts. This paper highlights the benefits of undertaking a mixed methods approach to evaluating active transport to school programs that enables both measurement and understanding of program impacts. PMID:23606865

t anti-t production cross section measurement using soft electron tagging in p anti-p collisions at √s = 1.96-TeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chou, John Paul

2008-09-01

We measure the production cross section of tmore » $$\\bar{t}$$ events in p$$\\bar{p}$$ collisions at √s = 1.96 TeV. The data was collected by the CDF experiment in Run 2 of the Tevatron accelerator at the Fermi National Accelerator Laboratory between 2002 and 2007. 1.7 fb -1 of data was recorded during this time period. We reconstruct t$$\\bar{t}$$ events in the lepton+jets channel, whereby one W boson - resulting from the decay of the top quark pairs - decays leptonically and the other hadronically. The dominant background to this process is the production of W bosons in association with multiple jets. To distinguish t$$\\bar{t}$$ from background, we identify soft electrons from the semileptonic decay of heavy flavor jets produced in t$$\\bar{t}$$ events. We measure a cross section of σ $$\\bar{p}$$ = 7.8 ± 2.4(stat) ± 1.6(syst) ± 0.5(lumi).« less

Neuroimaging supports behavioral personality assessment: Overlapping activations during reflective and impulsive risk taking.

PubMed

Pletzer, Belinda; M Ortner, Tuulia

2016-09-01

Personality assessment has been challenged by the fact that different assessment methods (implicit measures, behavioral measures and explicit rating scales) show little or no convergence in behavioral studies. In this neuroimaging study we address for the first time, whether different assessment methods rely on separate or overlapping neuronal systems. Fifty nine healthy adult participants completed two objective personality tests of risk propensity: the more implicit Balloon Analogue Risk Task (BART) and the more explicit Game of Dice Task (GDT). Significant differences in activation, as well as connectivity patterns between both tasks were observed. In both tasks, risky decisions yielded significantly stronger activations than safe decisions in the bilateral caudate, as well as the bilateral Insula. The finding of overlapping brain areas validates different assessment methods, despite their behavioral non-convergence. This suggests that neuroimaging can be an important tool of validation in the field of personality assessment. Copyright © 2016 Elsevier B.V. All rights reserved.

Reynolds-Averaged Navier-Stokes Simulation of a 2D Circulation Control Wind Tunnel Experiment

NASA Technical Reports Server (NTRS)

Allan, Brian G.; Jones, Greg; Lin, John C.

2011-01-01

Numerical simulations are performed using a Reynolds-averaged Navier-Stokes (RANS) flow solver for a circulation control airfoil. 2D and 3D simulation results are compared to a circulation control wind tunnel test conducted at the NASA Langley Basic Aerodynamics Research Tunnel (BART). The RANS simulations are compared to a low blowing case with a jet momentum coefficient, C(sub u), of 0:047 and a higher blowing case of 0.115. Three dimensional simulations of the model and tunnel walls show wall effects on the lift and airfoil surface pressures. These wall effects include a 4% decrease of the midspan sectional lift for the C(sub u) 0.115 blowing condition. Simulations comparing the performance of the Spalart Allmaras (SA) and Shear Stress Transport (SST) turbulence models are also made, showing the SST model compares best to the experimental data. A Rotational/Curvature Correction (RCC) to the turbulence model is also evaluated demonstrating an improvement in the CFD predictions.

An Experimental Investigation of the Flow Over the Rear End of a Notchback Automobile Configuration

NASA Technical Reports Server (NTRS)

Jenkins, Luther N.

2000-01-01

An experimental investigation of the flow over the rear end of a 0.16 scale notchback automobile configuration has been conducted in the NASA Langley Basic Aerodynamics Research Tunnel (BART). The objective of this work was to investigate the flow separation that occurs behind the backlight and obtain experimental data that can be used to understand the physics and time-averaged structure of the flow field. A three-component laser velocimeter was used to make non-intrusive, velocity measurements in the center plane and in a single cross-flow plane over the decklid. In addition to off-body measurements, flow conditions on the car surface were documented via surface flow visualization, boundary layer measurements, and surface pressures. The experimental data show several features previously identified by other researchers, but also reveal differences between the flow field associated with this particular configuration and the generally accepted models for the flow over a notchback rear end.

Star formation in Bok globules.

NASA Astrophysics Data System (ADS)

Reipurth, B.

1981-12-01

Among the many dark clouds seen projected against the luminous band of the Milky Way are a number of small, isolated compact clouds, which often exhibit a large degree of regularity. These objects are today known as Bok globules, after the Dutch-American astronomer Bart Bok, who more than 30 years aga singled out the globules as a group of special interest among the dark clouds. Bok globules usually have angular sizes of from a few arcminutes to about 20 arcminutes, with real sizes of typically 0.15 to 0.8 parsecs. It is generally not so easy to estimate the distance, and thus the dimensions, of a given globule. Most known globules are closer than 500 pc, since they normally are found by their obscuring effects, and more distant globules become less conspicuous because of foreground stars. A nearby, compact Bok globule is indeed a spectacular sight; when William Herschel for the first time saw a globule in his telescape, he exclaimed: ' Mein Gott, da ist ein Loch im Himmel.'

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aaboud, M.; Aad, G.; Abbott, B.

We present single lepton and dilepton kinematic distributions measured in dileptonic tmore » $$\\bar{t}$$ events produced in 20.2fb - 1 of √s=8 TeV pp collisions recorded by the ATLAS experiment at the LHC. Both absolute and normalised differential cross-sections are measured, using events with an opposite-charge eμ pair and one or two b-tagged jets. Furthermore, the cross-sections are measured in a fiducial region corresponding to the detector acceptance for leptons, and are compared to the predictions from a variety of Monte Carlo event generators, as well as fixed-order QCD calculations, exploring the sensitivity of the cross-sections to the gluon parton distribution function. Some of the distributions are also sensitive to the top quark pole mass; a combined fit of NLO fixed-order predictions to all the measured distributions yields a top quark mass value of m$$pole\\atop{t}$$=173.2±0.9±0.8±1.2 GeV, where the three uncertainties arise from data statistics, experimental systematics, and theoretical sources.« less

Predicting Vandalism in a General Youth Sample via the HEW Youth Development Model's Community Program Impact Scales, Age, and Sex.

ERIC Educational Resources Information Center

Truckenmiller, James L.

The former HEW National Strategy for Youth Development model was a community-based planning and procedural tool to enhance and to prevent delinquency through a process of youth needs assessments, needs targeted programs, and program impact evaluation. The program's 12 Impact Scales have been found to have acceptable reliabilities, substantial…

String Music Educators' Perceptions of the Impact of New String Programs on Student Outcomes, School Music Programs, and Communities

ERIC Educational Resources Information Center

Gillespie, Robert; Russell, Joshua A.; Hamann, Donald L.

2014-01-01

The purpose of this study was to examine the impact of newly initiated string programs on teachers, schools, districts, communities, and existing music program administration and students. Research questions pertained to (a) locations, student access, and instructional offerings; (b) educators; and (c) perceived impact on student outcomes. Data…

Estimating the Impacts of Direct Load Control Programs Using GridPIQ, a Web-Based Screening Tool

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pal, Seemita; Thayer, Brandon L.; Barrett, Emily L.

In direct load control (DLC) programs, utilities can curtail the demand of participating loads to contractually agreed-upon levels during periods of critical peak load, thereby reducing stress on the system, generation cost, and required transmission and generation capacity. Participating customers receive financial incentives. The impacts of implementing DLC programs extend well beyond peak shaving. There may be a shift of load proportional to the interrupted load to the times before or after a DLC event, and different load shifts have different consequences. Tools that can quantify the impacts of such programs on load curves, peak demand, emissions, and fossil fuelmore » costs are currently lacking. The Grid Project Impact Quantification (GridPIQ) screening tool includes a Direct Load Control module, which takes into account project-specific inputs as well as the larger system context in order to quantify the impacts of a given DLC program. This allows users (utilities, researchers, etc.) to test and compare different program specifications and their impacts.« less

Staff Attitudes Regarding the Impact of a Therapy Dog Program on Military Behavioral Health Patients.

PubMed

Brisson, Sara; Dekker, Anthony H

Human-animal interactions in the form of animal-assisted therapy (AAT) have become common in both civilian and military health care facilities. Evidence supports AAT as a beneficial therapeutic alternative for patients with physical disabilities and psychological disorders. Few studies have been conducted in the civilian health care setting to evaluate staff attitudes regarding the impact of an AAT program on behavioral health (BH) patients. To our knowledge, no research has examined staff attitudes on the impact and effectiveness of AAT on active-duty Servicemembers in a BH program at a military facility. At the completion of a year-long AAT dog program and after institutional review board exemption, an anonymous, six-question survey was used to examine staff attitudes (n = 29) regarding the impact and continuation of the program with military BH patients. Most staff members (86%) believed the AAT dog program had a positive impact on the BH patients, including improved patient mood, greater patient relaxation, improved patient attitude toward therapy, and increased social interactions among patients. All the staff reported a desire to continue the program at the military facility. Most BH staff thought the year-long AAT dog program had a positive impact on patients. All staff supported continuation of the program. 2017.

Treatment effects model for assessing disease management: measuring outcomes and strengthening program management.

PubMed

Wendel, Jeanne; Dumitras, Diana

2005-06-01

This paper describes an analytical methodology for obtaining statistically unbiased outcomes estimates for programs in which participation decisions may be correlated with variables that impact outcomes. This methodology is particularly useful for intraorganizational program evaluations conducted for business purposes. In this situation, data is likely to be available for a population of managed care members who are eligible to participate in a disease management (DM) program, with some electing to participate while others eschew the opportunity. The most pragmatic analytical strategy for in-house evaluation of such programs is likely to be the pre-intervention/post-intervention design in which the control group consists of people who were invited to participate in the DM program, but declined the invitation. Regression estimates of program impacts may be statistically biased if factors that impact participation decisions are correlated with outcomes measures. This paper describes an econometric procedure, the Treatment Effects model, developed to produce statistically unbiased estimates of program impacts in this type of situation. Two equations are estimated to (a) estimate the impacts of patient characteristics on decisions to participate in the program, and then (b) use this information to produce a statistically unbiased estimate of the impact of program participation on outcomes. This methodology is well-established in economics and econometrics, but has not been widely applied in the DM outcomes measurement literature; hence, this paper focuses on one illustrative application.

Impact of Alternative Programs on an Urban School District.

ERIC Educational Resources Information Center

Vincenzi, Harry; Fishman, Roger J.

The number of secondary alternative programs in the school district of Philadelphia has grown to 75 giving it one of the largest networks of alternative programs in the country. The object of this paper is to report on the impact of those programs. The programs are divided into four categories: (1) disruptive/ truant programs, (2) career programs,…

Impacts of a prekindergarten program on children's mathematics, language, literacy, executive function, and emotional skills.

PubMed

Weiland, Christina; Yoshikawa, Hirokazu

2013-01-01

Publicly funded prekindergarten programs have achieved small-to-large impacts on children's cognitive outcomes. The current study examined the impact of a prekindergarten program that implemented a coaching system and consistent literacy, language, and mathematics curricula on these and other nontargeted, essential components of school readiness, such as executive functioning. Participants included 2,018 four and five-year-old children. Findings indicated that the program had moderate-to-large impacts on children's language, literacy, numeracy and mathematics skills, and small impacts on children's executive functioning and a measure of emotion recognition. Some impacts were considerably larger for some subgroups. For urban public school districts, results inform important programmatic decisions. For policy makers, results confirm that prekindergarten programs can improve educationally vital outcomes for children in meaningful, important ways. © 2013 The Authors. Child Development © 2013 Society for Research in Child Development, Inc.

From professional development for science teachers to student learning in science

NASA Astrophysics Data System (ADS)

Tinoca, Luis Fonseca

This study investigates the effects of professional development for science teachers on student learning. It is usually expected that professional development programs positively impact student learning, however this dimension is not commonly incorporated in the programs evaluation. It is simply assumed that students will be indirectly impacted through their participating teachers in the work with their students. Two main research questions are addressed: (1) Are professional development programs effective in enhancing student learning in science? (2) What are the characteristics of the most and least effective programs? To answer these questions a meta-analysis of 37 professional development programs reporting their impact on student learning was performed. Program characteristics have been defined according to the categories defined by Loucks-Horsley et al (1998), the National Science Education Standards (NRC, 1996), as well as new categories developed by us analyzing other variables such as the programs length. A significant impact of professional development for science teachers on student learning has been found in the form of an overall correlation effect size of r = 0.22 (p < 0.001). Moreover, a Fixed Effects Model was used to differentiate between the impacts of the different characteristics of professional development programs for science teachers. In particular, programs emphasizing work on curriculum development, replacement, or implementation, scientific inquiry, pedagogical content knowledge, lasting over 6 month and with a total duration of at least 100 hours have been identified as having a larger impact on student learning. To enhance the findings vignettes have been developed based on the attained effect sizes describing possible professional development programs. Recommendations for present and future professional development programs are made based on what works best in order to maximize their impact on student learning.

Uranium Leasing Program PEIS Information Center

Science.gov Websites

Search Go search Uranium Leasing Program Programmatic Environmental Impact Statement Information Center Environmental Impact Statement (PEIS) for the Uranium Leasing Program. The United States Department of Energy (DOE) Office of Legacy Management (LM) has prepared a Programmatic Environmental Impact Statement (PEIS

School Leadership Development in Western Australia: An Impact Study.

ERIC Educational Resources Information Center

Wildy, Helen; Wallace, John

1995-01-01

Reports an impact study of the Western Australian School Leadership Program, a development program for administrators. Questionnaires completed by 357 program participants and 287 colleagues indicated the impact of the training on leader behavior in schools. The effect was enhanced when several leaders from the same school had participated. (SLD)

Impact of Cohort Bonds on Student Satisfaction and Engagement

ERIC Educational Resources Information Center

Martin, Kimberly A.; Goldwasser, Molly M.; Galentino, Richard

2017-01-01

This study examines differences in student satisfaction and engagement in cohort programs versus traditional, non-cohort educational programs by studying the impact of close bonds between students. The authors measure and compare "close bonds" within an educational cohort to a traditional program and measure the impact of close bonds on…

SoTL[superscript 2]: Inquiring into the Impact of Inquiry

ERIC Educational Resources Information Center

Miller-Young, Janice; Yeo, Michelle; Manarin, Karen; Carey, Miriam; Zimmer, Jim

2016-01-01

This chapter briefly describes the SoTL research development program and context at Mount Royal University, reports initial results from a study of the program's impact on participants' teaching and scholarly activities, and situates the findings regarding individual impact, department-level impact, institution-level impact, and discipline-level…

Regression Verification Using Impact Summaries

NASA Technical Reports Server (NTRS)

Backes, John; Person, Suzette J.; Rungta, Neha; Thachuk, Oksana

2013-01-01

Regression verification techniques are used to prove equivalence of syntactically similar programs. Checking equivalence of large programs, however, can be computationally expensive. Existing regression verification techniques rely on abstraction and decomposition techniques to reduce the computational effort of checking equivalence of the entire program. These techniques are sound but not complete. In this work, we propose a novel approach to improve scalability of regression verification by classifying the program behaviors generated during symbolic execution as either impacted or unimpacted. Our technique uses a combination of static analysis and symbolic execution to generate summaries of impacted program behaviors. The impact summaries are then checked for equivalence using an o-the-shelf decision procedure. We prove that our approach is both sound and complete for sequential programs, with respect to the depth bound of symbolic execution. Our evaluation on a set of sequential C artifacts shows that reducing the size of the summaries can help reduce the cost of software equivalence checking. Various reduction, abstraction, and compositional techniques have been developed to help scale software verification techniques to industrial-sized systems. Although such techniques have greatly increased the size and complexity of systems that can be checked, analysis of large software systems remains costly. Regression analysis techniques, e.g., regression testing [16], regression model checking [22], and regression verification [19], restrict the scope of the analysis by leveraging the differences between program versions. These techniques are based on the idea that if code is checked early in development, then subsequent versions can be checked against a prior (checked) version, leveraging the results of the previous analysis to reduce analysis cost of the current version. Regression verification addresses the problem of proving equivalence of closely related program versions [19]. These techniques compare two programs with a large degree of syntactic similarity to prove that portions of one program version are equivalent to the other. Regression verification can be used for guaranteeing backward compatibility, and for showing behavioral equivalence in programs with syntactic differences, e.g., when a program is refactored to improve its performance, maintainability, or readability. Existing regression verification techniques leverage similarities between program versions by using abstraction and decomposition techniques to improve scalability of the analysis [10, 12, 19]. The abstractions and decomposition in the these techniques, e.g., summaries of unchanged code [12] or semantically equivalent methods [19], compute an over-approximation of the program behaviors. The equivalence checking results of these techniques are sound but not complete-they may characterize programs as not functionally equivalent when, in fact, they are equivalent. In this work we describe a novel approach that leverages the impact of the differences between two programs for scaling regression verification. We partition program behaviors of each version into (a) behaviors impacted by the changes and (b) behaviors not impacted (unimpacted) by the changes. Only the impacted program behaviors are used during equivalence checking. We then prove that checking equivalence of the impacted program behaviors is equivalent to checking equivalence of all program behaviors for a given depth bound. In this work we use symbolic execution to generate the program behaviors and leverage control- and data-dependence information to facilitate the partitioning of program behaviors. The impacted program behaviors are termed as impact summaries. The dependence analyses that facilitate the generation of the impact summaries, we believe, could be used in conjunction with other abstraction and decomposition based approaches, [10, 12], as a complementary reduction technique. An evaluation of our regression verification technique shows that our approach is capable of leveraging similarities between program versions to reduce the size of the queries and the time required to check for logical equivalence. The main contributions of this work are: - A regression verification technique to generate impact summaries that can be checked for functional equivalence using an off-the-shelf decision procedure. - A proof that our approach is sound and complete with respect to the depth bound of symbolic execution. - An implementation of our technique using the LLVMcompiler infrastructure, the klee Symbolic Virtual Machine [4], and a variety of Satisfiability Modulo Theory (SMT) solvers, e.g., STP [7] and Z3 [6]. - An empirical evaluation on a set of C artifacts which shows that the use of impact summaries can reduce the cost of regression verification.

Contributions of Arctic PRISM to monitoring western hemispheric shorebirds

USGS Publications Warehouse

Skagen, Susan K.; Smith, Paul A.; Andres, Brad A.; Donaldson, Garry; Brown, Stephen

2012-01-01

Long-term monitoring of populations is of paramount importance to understanding responses oforganisms to global environmental change and to evaluating whether conservation practices are yielding intended results through time (Wiens 2009). The population status of many shorebird species, the focus of this volume, remain poorly known. Long-distance migrant shorebirds have proven particularly difficult to monitor, in part because of their highly migratory nature and ranges that extend into highly inaccessible regions. As migrant shorebirds travel the length of the hemisphere, they congregate and disperse in ways that vary among species, locations, and years, presenting serious challenges to designing and implementing monitoring programs. Rigorous field and quantitative methods that estimate population size and monitor trends are vitally needed to direct and evaluate effective conservation measures. Many management efforts depend on unbiased population size estimates; for example, the shorebird conservation plans for both Canada and the United States seek to restore populations to levels calculated for the 1970s based on the best information available from existing surveys. Further, federal wildlife agencies within the United States and Canada have mandates to understand the state of their nations' resources under various conventions for the protection of migratory birds. Accurate estimates of population size are vital statistics for a variety of conservation activities, such as prioritizing species for conservation action and setting management targets. Areas of essential habitat, such as those designated under the Western Hemisphere Shorebird Reserve Network, the Important Bird Areas program of BirdLife International and the National Audubon Society, or Canada's National Wildlife Areas program, are all evaluated on the basis ofproportions of species' populations which they contain. The size, and trends in size, ofa species' population are considered key information for assessing its vulnerability and subsequent listing under the U.S. Endangered Species Act and the Canadian Species at Risk Act. To meet the need for information on population size and trends, shorebird biologists from Canada and the United States proposed a shared blueprint for shorebird monitoring across the Western Hemisphere in the late 1990s; this effort was undertaken in concert with the development of the Canadian and U.S. Shorebird Conservation Plans (Donaldson et al. 2000, Brown et aL 2001). Soon thereafter, partners in the monitoring effort adopted the name "Program for Regional and International Shorebird Monitoring" (PRISM). Among the primary objectives of PRISM were to estimate the population sizes and trends of breeding North American shorebirds and describe their distributions (Bart et al. 2002). PRISM members evaluated ongoing and potential monitoring approaches to address 74 taxa (including subspecies) and proposed a combination of arctic andboreal breeding surveys, temperate breeding and non-breeding surveys, and neotropical surveys.

The Total Impact of Manpower Programs: A Four-City Case Study. Volume II--Final Report.

ERIC Educational Resources Information Center

Olympus Research Corp., Washington, DC.

Based on followup interviews with 1700 participants, this study is an evaluation of Federal manpower programs in Boston, Denver, and San Francisco-Oakland. Included are Manpower Development and Training Act Programs, Work Incentive Programs, and Concentrated Employment Program from late 1969 to early 1970. Program impact on enrollees, employers,…

Health for Life in Primary Schools Program, United Kingdom: a Program Impact Pathways (PIP) analysis.

PubMed

Passmore, Sandra; Donovan, Martin

2014-09-01

The Health for Life in Primary Schools Program helps schools promote healthy, active lifestyles through curriculum support related to healthy eating and cooking, growing food, physical activity, and family involvement. These interrelated strands are shown to have the greatest impact on healthy lifestyles, and the Health for Life in Primary Schools Program seeks to make these not one-off lessons, but a sustainable part of a school's culture. Each school involved with the program develops its own Action Plan in order to achieve program goals. Each school is assessed by an audit of facilities, skills, and curriculum at baseline and follow-up, and the pupils complete an on-line questionnaire at baseline and follow-up. Other impact measures are individual to the school and relate to its own Action Plan. Health for Life in Primary Schools sought to assess the cohesiveness and strength of the program using the Program Impact Pathways (PIP) model. The program was deconstructed to its individual parts, with each part assessed in terms of its contribution to the overall program and constraints upon its effectiveness. The PIP analysis helped clarify the logic and structure of the program, whether its objectives can be achieved, the Critical Quality Control Points (CCPs), and the impact measures required to demonstrate success. The core indicators identified for impact evaluation were knowledge, attitudes, and behaviors of pupils around healthy eating cooking, growing food, and physical activity. The PIP model confirmed that the Health for Life in Primary Schools Program is well structured and is well suited to achieve its goals. The findings were presented at the Healthy Lifestyles Program Evaluation Workshop held in Granada, Spain, 13-14 September 2013, under the auspices of the Mondelēz International Foundation.

Impact of the Kenya Cash Transfer for Orphans and Vulnerable Children on early pregnancy and marriage of adolescent girls.

PubMed

Handa, Sudhanshu; Peterman, Amber; Huang, Carolyn; Halpern, Carolyn; Pettifor, Audrey; Thirumurthy, Harsha

2015-09-01

There is promising evidence that poverty-targeted cash transfer programs can have positive impacts on adolescent transitions to adulthood in resource poor settings, however existing research is typically from small scale programs in diverse geographic and cultural settings. We provide estimates of the impact of a national unconditional cash transfer program, the Kenya Cash Transfer for Orphans and Vulnerable Children, on pregnancy and early marriage among females aged 12 to 24, four years after program initiation. The evaluation was designed as a clustered randomized controlled trial and ran from 2007 to 2011, capitalizing on the existence of a control group, which was delayed entry to the program due to budget constraints. Findings indicate that, among 1549 females included in the study, while the program reduced the likelihood of pregnancy by five percentage points, there was no significant impact on likelihood of early marriage. Program impacts on pregnancy appear to work through increasing the enrollment of young women in school, financial stability of the household and delayed age at first sex. The Kenyan program is similar in design to most other major national cash transfer programs in Eastern and Southern Africa, suggesting a degree of generalizability of the results reported here. Although the objective of the program is primarily poverty alleviation, it appears to have an important impact on facilitating the successful transition of adolescent girls into adulthood. Copyright © 2015 Elsevier Ltd. All rights reserved.

Impact of the Kenya Cash Transfer for Orphans and Vulnerable Children on early pregnancy and marriage of adolescent girls

PubMed Central

Handa, Sudhanshu; Huang, Carolyn; Halpern, Carolyn; Pettifor, Audrey; Thirumurthy, Harsha

2015-01-01

There is promising evidence that poverty-targeted cash transfer programs can have positive impacts on adolescent transitions to adulthood in resource poor settings, however existing research is typically from small scale programs in diverse geographic and cultural settings. We provide estimates of the impact of a national unconditional cash transfer program, the Kenya Cash Transfer for Orphans and Vulnerable Children, on pregnancy and early marriage among females aged 12 to 24, four years after program initiation. The evaluation was designed as a clustered randomized controlled trial and ran from 2007 to 2011, capitalizing on the existence of a control group, which was delayed entry to the program due to budget constraints. Findings indicate that, among 1,549 females included in the study, while the program reduced the likelihood of pregnancy by five percentage points, there was no significant impact on likelihood of early marriage. Program impacts on pregnancy appear to work through increasing the enrollment of young women in school, financial stability of the household and delayed age at first sex. The Kenyan program is similar in design to most other major national cash transfer programs in Eastern and Southern Africa, suggesting a degree of generalizability of the results reported here. Although the objective of the program is primarily poverty alleviation, it appears to have an important impact on facilitating the successful transition of adolescent girls into adulthood. PMID:26246032

The perceived impact of a university outdoor education program on students' environmental behaviors

Treesearch

Heather Boland; Paul Heintzman

2010-01-01

Outdoor educators often seek to design programs that influence participants' daily lifestyles, especially environmental behaviors. Research on the impact of outdoor education programs on environmental behaviors has typically focused on schoolchildren and teenagers. The purpose of this study was to investigate the perceived impact of a university outdoor education...

Impacts of a Prekindergarten Program on Children's Mathematics, Language, Literacy, Executive Function, and Emotional Skills

ERIC Educational Resources Information Center

Weiland, Christina; Yoshikawa, Hirokazu

2013-01-01

Publicly funded prekindergarten programs have achieved small-to-large impacts on children's cognitive outcomes. The current study examined the impact of a prekindergarten program that implemented a coaching system and consistent literacy, language, and mathematics curricula on these and other nontargeted, essential components of school readiness,…

The Impact of IMPACT II.

ERIC Educational Resources Information Center

Mann, Dale

IMPACT II is a teacher-to-teacher networking program designed to improve teaching in New York City schools. Teachers who have been working on new ideas that need more refinement are eligible for $300 grants offered to program developers. Teachers who would like to adopt ideas previously developed by the program may receive $200 as replicator…

48 CFR 222.101-3-70 - Impact of labor disputes on defense programs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Impact of labor disputes... ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE SOCIOECONOMIC PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Basic Labor Policies 222.101-3-70 Impact of labor disputes on defense programs. (a...

Retrospective Analysis of the Benefits and Impacts of U.S. Renewable Portfolio Standards

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiser, Ryan; Barbose, Galen; Heeter, Jenny

This analysis is the first-ever comprehensive assessment of the benefits and impacts of state renewable portfolio standards (RPSs). This joint National Renewable Energy Laboratory-Lawrence Berkeley National Laboratory project provides a retrospective analysis of RPS program benefits and impacts, including greenhouse gas emissions reductions, air pollution emission reductions, water use reductions, gross jobs and economic development impacts, wholesale electricity price reduction impacts, and natural gas price reduction impacts. Wherever possible, benefits and impacts are quantified in monetary terms. The paper will inform state policymakers, RPS program administrators, industry, and others about the costs and benefits of state RPS programs. In particular,more » the work seeks to inform decision-making surrounding ongoing legislative proposals to scale back, freeze, or expand existing RPS programs, as well as future discussions about increasing RPS targets or otherwise increasing renewable energy associated with Clean Power Plan compliance or other emission-reduction goals.« less

Impact of a 4-H Youth Development Program on At-Risk Urban Teenagers

ERIC Educational Resources Information Center

Cutz, German; Campbell, Benjamin; Filchak, Karen K.; Valiquette, Edith; Welch, Mary Ellen

2015-01-01

Dynamic programs that integrate science literacy and workforce readiness are essential to today's youth. The program reported here combined science literacy (gardening and technology) with workforce readiness to assess the impact of program type, prior program participation, and behavior/punctuality on knowledge gain. Findings show that past…

Broadening measures of success: results of a behavioral health translational research training program.

PubMed

Baldwin, Julie A; Williamson, Heather J; Eaves, Emery R; Levin, Bruce L; Burton, Donna L; Massey, Oliver T

2017-07-24

While some research training programs have considered the importance of mentoring in inspiring professionals to engage in translational research, most evaluations emphasize outcomes specific to academic productivity as primary measures of training program success. The impact of such training or mentoring programs on stakeholders and local community organizations engaged in translational research efforts has received little attention. The purpose of this evaluation is to explore outcomes other than traditional academic productivity in a translational research graduate certificate program designed to pair graduate students and behavioral health professionals in collaborative service-learning projects. Semi-structured qualitative interviews with scholars, community mentors, and academic mentors were conducted regarding a translational research program to identify programmatic impacts. Interviews were transcribed and coded by the research team to identify salient themes related to programmatic outcomes. Results are framed using the Translational Research Impact Scale which is organized into three overarching domains of potential impact: (1) research-related impacts, (2) translational impacts, and (3) societal impacts. This evaluation demonstrates the program's impact in all three domains of the TRIS evaluation framework. Graduate certificate participants (scholars) reported that gaining experience in applied behavioral health settings added useful skills and expertise to their present careers and increased their interest in pursuing translational research. Scholars also described benefits resulting from networks gained through participation in the program, including valuable ties between the university and community behavioral health organizations. This evaluation of the outcomes of a graduate certificate program providing training in translational research highlights the need for more community-oriented and practice-based measures of success. Encouraging practitioner involvement in translational research is vital to translate knowledge into practice and to enable practice-based needs to inform research and policy. A more flexible approach to measuring programmatic success in research training programs can help bridge the knowledge translation gap.

Experimental impacts of a teacher professional development program in Chile on preschool classroom quality and child outcomes.

PubMed

Yoshikawa, Hirokazu; Leyva, Diana; Snow, Catherine E; Treviño, Ernesto; Barata, M Clara; Weiland, Christina; Gomez, Celia J; Moreno, Lorenzo; Rolla, Andrea; D'Sa, Nikhit; Arbour, Mary Catherine

2015-03-01

We assessed impacts on classroom quality and on 5 child language and behavioral outcomes of a 2-year teacher professional-development program for publicly funded prekindergarten and kindergarten in Chile. This cluster-randomized trial included 64 schools (child N = 1,876). The program incorporated workshops and in-classroom coaching. We found moderate to large positive impacts on observed emotional and instructional support as well as classroom organization in prekindergarten classrooms after 1 year of the program. After 2 years of the program, moderate positive impacts were observed on emotional support and classroom organization. No significant program impacts on child outcomes were detected at posttest (1 marginal effect, an increase in a composite of self-regulation and low problem behaviors, was observed). Professional development for preschool teachers in Chile can improve classroom quality. More intensive curricular approaches are needed for these improvements to translate into effects on children. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

The impact of banners on digital television: the role of program interactivity and product involvement.

PubMed

Cauberghe, Verolien; De Pelsmacker, Patrick

2008-02-01

In a sample of 281 respondents, the effect of a noninteractive and a medium-interactive television program on recall and brand attitudes for low- and high-involvement products advertised in banners during these programs was investigated. Medium-interactive programs resulted in less product and brand recall and recognition of brands in embedded banner advertisements, but generated more positive brand attitudes than noninteractive programs. These effects were more outspoken for a high-involvement product than for a low-involvement product. The impact of perceived program interactivity on brand attitude is fully mediated program valence and involvement for low-involvement products, but not for high-involvement products, for which perceived program interactivity had a direct impact on brand attitude.

A Qualitative Study of Elementary Afterschool Teachers' Perceptions of the Impact of Afterschool Programs on Students Receiving Special Education Services

ERIC Educational Resources Information Center

Legaspi, Margareth

2013-01-01

The purpose of this study, "A Qualitative Study of Elementary Afterschool Teachers' Perceptions of the Impact of Afterschool Programs on Students Receiving Special Education Services," was to assess elementary afterschool teachers' perceptions of the impact of afterschool programs on students receiving special education…

Perceived Factors Impacting School Music Programs: The Teacher's Perspective

ERIC Educational Resources Information Center

Abril, Carlos R.; Bannerman, Julie K.

2015-01-01

The purpose of this study was to examine elementary music teachers' perceptions of factors impacting their music programs and teaching positions as well as the actions these teachers take in response to those factors. The following research questions guided the study: (1) What factors are perceived to impact music programs and teaching…

Shifting Challenges in Teacher-Education Research and Accreditation: Lessons Learned from Limitations on Studying Program Impact

ERIC Educational Resources Information Center

Contopidis, Ellen; DaBoll-Lavoie, Kathleen; Dunn, Kerry; Darling, Deana; Wieczorek, Kim

2017-01-01

A critical issue in educator preparation is how to ascertain if program graduates are sufficiently prepared to be effective through the acquisition of meaningful evidence of graduates' impact on their students. Challenges to proving specific impact of educator-preparation programs on student learning include identifying and following program…

SSAIS: A Program to Assess Adverse Impact in Multistage Selection Decisions

ERIC Educational Resources Information Center

De Corte, Wilfried

2004-01-01

The article describes a Windows program to estimate the expected value and sampling distribution function of the adverse impact ratio for general multistage selections. The results of the program can also be used to predict the risk that a future selection decision will result in an outcome that reflects the presence of adverse impact. The method…

Earth Impact Effects Program: Estimating the Regional Environmental Consequences of Impacts On Earth

NASA Astrophysics Data System (ADS)

Collins, G. S.; Melosh, H. J.; Marcus, R. A.

2009-12-01

The Earth Impact Effects Program (www.lpl.arizona.edu/impacteffects) is a popular web-based calculator for estimating the regional environmental consequences of a comet or asteroid impact on Earth. It is widely used, both by inquisitive members of the public as an educational device and by scientists as a simple research tool. It applies a variety of scaling laws, based on theory, nuclear explosion test data, observations from terrestrial and extraterrestrial craters and the results of small-scale impact experiments and numerical modelling, to quantify the principal hazards that might affect the people, buildings and landscape in the vicinity of an impact. The program requires six inputs: impactor diameter, impactor density, impact velocity prior to atmospheric entry, impact angle, and the target type (sedimentary rock, crystalline rock, or a water layer above rock), as well as the distance from the impact at which the environmental effects are to be calculated. The program includes simple algorithms for estimating the fate of the impactor during atmospheric traverse, the thermal radiation emitted by the impact plume (fireball) and the intensity of seismic shaking. The program also approximates various dimensions of the impact crater and ejecta deposit, as well as estimating the severity of the air blast in both crater-forming and airburst impacts. We illustrate the strengths and limitations of the program by comparing its predictions (where possible) against known impacts, such as Carancas, Peru (2007); Tunguska, Siberia (1908); Barringer (Meteor) crater, Arizona (ca 49 ka). These tests demonstrate that, while adequate for large impactors, the simple approximation of atmospheric entry in the original program does not properly account for the disruption and dispersal of small impactors as they traverse Earth's atmosphere. We describe recent improvements to the calculator to better describe atmospheric entry of small meteors; the consequences of oceanic impacts; and the recurrance interval between impacts of a given size. In addition, we assess the potential regional hazard of hypothetical impact scenarios of different scales. Our simple calculator suggests that the most wide-reaching regional hazard is seismic shaking: both ejecta-deposit thickness and airblast pressure decay much more rapidly with distance than seismic ground motion. Close to the impact site the most severe hazard is from thermal radiation; however, the curvature of the Earth implies that distant localities are shielded from direct thermal radiation because the fireball is below the horizon.

7 CFR 1948.81 - State Investment Strategy for Energy Impacted Areas.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 13 2011-01-01 2009-01-01 true State Investment Strategy for Energy Impacted Areas..., DEPARTMENT OF AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED) RURAL DEVELOPMENT Section 601 Energy Impacted Area Development Assistance Program § 1948.81 State Investment Strategy for Energy Impacted Areas...

7 CFR 1948.81 - State Investment Strategy for Energy Impacted Areas.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 13 2013-01-01 2013-01-01 false State Investment Strategy for Energy Impacted Areas..., DEPARTMENT OF AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED) RURAL DEVELOPMENT Section 601 Energy Impacted Area Development Assistance Program § 1948.81 State Investment Strategy for Energy Impacted Areas...

7 CFR 1948.81 - State Investment Strategy for Energy Impacted Areas.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 13 2010-01-01 2009-01-01 true State Investment Strategy for Energy Impacted Areas..., DEPARTMENT OF AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED) RURAL DEVELOPMENT Section 601 Energy Impacted Area Development Assistance Program § 1948.81 State Investment Strategy for Energy Impacted Areas...

A quantitative approach to assessing the efficacy of occupant protection programs: A case study from Montana.

PubMed

Manlove, Kezia; Stanley, Laura; Peck, Alyssa

2015-10-01

Quantitative evaluation of vehicle occupant protection programs is critical for ensuring efficient government resource allocation, but few methods exist for conducting evaluation across multiple programs simultaneously. Here we present an analysis of occupant protection efficacy in the state of Montana. This approach relies on seat belt compliance rates as measured by the National Occupant Protection Usage Survey (NOPUS). A hierarchical logistic regression model is used to estimate the impacts of four Montana Department of Transportation (MDT)-funded occupant protection programs used in the state of Montana, following adjustment for a suite of potential confounders. Activity from two programs, Buckle Up coalitions and media campaigns, are associated with increased seat belt use in Montana, whereas the impact of another program, Selective Traffic Enforcement, is potentially masked by other program activity. A final program, Driver's Education, is not associated with any shift in seat belt use. This method allows for a preliminary quantitative estimation of program impacts without requiring states to obtain any new seat belt use data. This approach provides states a preliminary look at program impacts, and a means for carefully planning future program allocation and investigation. Copyright © 2015 Elsevier Ltd. All rights reserved.

Factors Influencing Participant Perceptions of Program Impact: Lessons from a Virtual Fieldtrip for Middle-School Students

ERIC Educational Resources Information Center

Adedokun, Omolola A.; Parker, Loran C.; Loizzo, Jamie; Burgess, Wilella D.; Robinson, J. Paul

2011-01-01

Participant perceptions of program effectiveness and impact are undoubtedly a popular focus of Extension program evaluations. However, the effects of participants' characteristics and contextual variables on program perceptions and how the resulting data can be used for program improvement are less explored in evaluation studies. Using data from…

How Do School-Based Prevention Programs Impact Teachers? Findings from a Randomized Trial of an Integrated Classroom Management and Social-Emotional Program.

PubMed

Domitrovich, Celene E; Bradshaw, Catherine P; Berg, Juliette K; Pas, Elise T; Becker, Kimberly D; Musci, Rashelle; Embry, Dennis D; Ialongo, Nicholas

2016-04-01

A number of classroom-based interventions have been developed to improve social and behavioral outcomes for students, yet few studies have examined how these programs impact the teachers who are implementing them. Impacts on teachers may affect students and therefore also serve as an important proximal outcome to examine. The current study draws upon data from a school-based randomized controlled trial testing the impact of two prevention programs. In one intervention condition, teachers were trained in the classroom behavior management program, PAX Good Behavior Game (PAX GBG). In a second intervention condition, teachers were trained to use an integrated program, referred to as PATHS to PAX, of the PAX GBG and a social and emotional learning curriculum called Promoting Alternative Thinking Strategies (PATHS©). This study aimed to determine whether both interventions positively impacted teachers, with a particular interest in the teachers' own beliefs and perceptions regarding self-efficacy, burnout, and social-emotional competence. The sample included 350 K-5 teachers across 27 schools (18 schools randomized to intervention, 9 to control). Multilevel latent growth curve analyses indicated that the PATHS to PAX condition generally demonstrated the most benefits to teachers, relative to both the control and PAX GBG conditions. These findings suggest that school-based preventive interventions can have a positive impact on teachers' beliefs and perceptions, particularly when the program includes a social-emotional component. Several possible mechanisms might account for the added benefit to teachers. Additional research is needed to better understand how these programs impact teachers, as well as students.

Impact of a Ninth-Grade Transition Program on Cumulative GPAs and Credits, Ninth-Grade Dropout Rates, and Student Satisfaction

ERIC Educational Resources Information Center

Buhrman, B. R.

2010-01-01

Concerned educators have been implementing ninth-grade transition programs to help freshmen adjust to the demands in high school and to reduce ninth-grade failure rates. The purpose of this quasi-experimental quantitative study was to investigate the impact of a ninth-grade transition program. The research questions addressed impact on cumulative…

The Fiscal Impact of the Kentucky Education Tax Credit Program

ERIC Educational Resources Information Center

Gottlob, Brian J.

2006-01-01

This study examines the fiscal impact of a proposal to create a personal tax credit for educational expenses and a tax-credit scholarship program in Kentucky. It finds that the actual fiscal impact of the program would be much less than its nominal dollar size, due to the reduced public school costs resulting from migration of students from public…

The Impact of Elementary Gifted Mathematics Programming: Moving into Middle School Research Using the ECLS-K Database

ERIC Educational Resources Information Center

Zayac, Joanne M.

2013-01-01

With tightened school budgets, school administrators need to know the short term and long range effects of providing gifted programs at the elementary level. Programming opportunities in elementary school have direct impact on middle school and this, in turn impacts high school and college course selection. This study used the Early Childhood…

MISOE [Management Information System for Occupational Education] Impact Battery.

ERIC Educational Resources Information Center

Conroy, William G., Jr.

The impact battery consists of two instruments used to obtain impact data (descriptions of the experiences of program completors during post-program life) for the Sample Data Systems of the Management Information System for Occupational Education (MISOE). The first, Massachusetts Educational Impact Instrument (MEII), is an 11-page extensive…

78 FR 50026 - Energy Efficiency and Conservation Loan Program Finding of No Significant Impact

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-16

... impact analysis documented in a programmatic environmental assessment of the new program that was issued... environment. Therefore, RUS will not prepare an environmental impact statement for its rulemaking adding... Finding of No Significant Impact AGENCY: Rural Utilities Service, USDA. ACTION: Notice of availability of...

The Impact of Prior Programming Knowledge on Lecture Attendance and Final Exam

ERIC Educational Resources Information Center

Veerasamy, Ashok Kumar; D'Souza, Daryl; Lindén, Rolf; Laakso, Mikko-Jussi

2018-01-01

In this article, we report the results of the impact of prior programming knowledge (PPK) on lecture attendance (LA) and on subsequent final programming exam performance in a university level introductory programming course. This study used Spearman's rank correlation coefficient, multiple regression, Kruskal-Wallis, and Bonferroni correction…

Portrait of a Work-Study Program Assessment

ERIC Educational Resources Information Center

Ghant, Walter A.; Horst, S. Jeanne; Whetstone, Devon H.

2016-01-01

Institutions of higher education invest time and money directing cocurricular programs that allow students to formally engage in the local community. Community-service learning is one type of program recently dubbed "high impact" (Kuh, 2008). However, it is not enough to simply refer to a program as "high impact": it is…

Uncertain Times 2012: Afterschool Programs Still Struggling in Today's Economy

ERIC Educational Resources Information Center

Afterschool Alliance, 2012

2012-01-01

"Uncertain Times 2012," conducted by the Afterschool Alliance between April 25 and June 8, 2012, assesses the impact of economic conditions on afterschool programs. While many studies have evaluated the impact of programs, "Uncertain Times" is the only research to examine the fiscal health of afterschool programs and their…

ITOS/space shuttle study

NASA Technical Reports Server (NTRS)

1971-01-01

The results are reported of a study to explore the potential cost reductions in the operational ITOS weather satellite program as a consequence of shuttle/bug availability for satellite placement and retrieval, and satellite servicing and maintenance. The study program was divided into shuttle impact on equipment and testing costs, and shuttle impact on overall future ITOS operational program costs, and shuttle impact on configuration. It is concluded that savings in recurring spacecraft costs can be realized in the 1978 ITOS program, if a space shuttle is utilized.

Social protection for all ages? Impacts of Ethiopia's Productive Safety Net Program on child nutrition.

PubMed

Porter, Catherine; Goyal, Radhika

2016-06-01

We investigate the impact of a large-scale social protection scheme, the Productive Safety Net Program (PSNP) in Ethiopia, on child nutritional outcomes. Children living in households that receive cash transfers should experience improved child nutrition. However, in the case of the PSNP, which for the majority of participants is a public works program, there are several potential threats to finding effects: first, without conditionality on child inputs, increased household income may not be translated into improved child nutrition. Second, the work requirement may impact on parental time, child time use and calories burned. Third, if there is a critical period for child human capital investment that closes before the age of 5 then children above this age may not see any improvement in medium-term nutritional outcomes, measured here as height-for-age. Using a cohort study that collected data both pre-and post-program implementation in 2002, 2006 and 2009, we exploit several novel aspects of the survey design to find estimates that can deal with non-random program placement. We present both matching and difference-in-differences estimates for the index children, as well as sibling-differences. Our estimates show an important positive medium-term nutritional impact of the program for children aged 5-15 that are comparable in size to Conditional Cash Transfer program impacts for much younger children. We show indicative evidence that the program impact on improved nutrition is associated with improved food security and reduced child working hours. Our robustness checks restrict the comparison group, by including only households who were shortlisted, but never received PSNP, and also exclude those who never received aid, thus identifying impact based on timing alone. We cannot rule out that the nutritional impact of the program is the same for younger and older children. Copyright © 2016 Elsevier Ltd. All rights reserved.

45 CFR 284.30 - What information must the State include in its assessment of the impact of the TANF program(s) in...

Code of Federal Regulations, 2010 CFR

2010-10-01

... assessment of the impact of the TANF program(s) in the State on the increase in child poverty? 284.30 Section... FOR DETERMINING WHETHER AN INCREASE IN A STATE OR TERRITORY'S CHILD POVERTY RATE IS THE RESULT OF THE... TANF program(s) in the State on the increase in child poverty? (a) The State's assessment must: (1...

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wiser, Ryan; Barbose, Galen; Heeter, Jenny

This analysis is the first-ever comprehensive assessment of the benefits and impacts of state renewable portfolio standards (RPSs). This joint National Renewable Energy Laboratory-Lawrence Berkeley National Laboratory project provides a retrospective analysis of RPS program benefits and impacts, including greenhouse gas emissions reductions, air pollution emission reductions, water use reductions, gross jobs and economic development impacts, wholesale electricity price reduction impacts, and natural gas price reduction impacts. Wherever possible, benefits and impacts are quantified in monetary terms. The paper will inform state policymakers, RPS program administrators, industry, and others about the costs and benefits of state RPS programs. In particular,more » the work seeks to inform decision-making surrounding ongoing legislative proposals to scale back, freeze, or expand existing RPS programs, as well as future discussions about increasing RPS targets or otherwise increasing renewable energy associated with Clean Power Plan compliance or other emission-reduction goals.« less

National Weatherization Assistance Program Impact Evaluation: Energy Impacts for Large Multifamily Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blasnik, Michael; Dalhoff, Greg; Carroll, David

This report estimates energy savings, energy cost savings, and cost effectiveness attributable to weatherizing large multifamily buildings under the auspices of the Department of Energy's Weatherization Assistance Program during Program Year 2008.

National Weatherization Assistance Program Impact Evaluation: Energy Impacts for Small Multifamily Buildings

DOE Office of Scientific and Technical Information (OSTI.GOV)

Blasnik, Michael; Dalhoff, Greg; Carroll, David

2014-09-01

This report estimates energy savings, energy cost savings, and cost effectiveness attributable to weatherizing small multifamily buildings under the auspices of the Department of Energy's Weatherization Assistance Program during Program Year 2008.

Do Developmental Mathematics Programs Have a Causal Impact on Student Retention? An Application of Discrete-Time Survival and Regression-Discontinuity Analysis

ERIC Educational Resources Information Center

Lesik, Sally A.

2007-01-01

The impact of academic programs--such as developmental mathematics programs--on student retention, has been a controversial topic for administrators, policy makers, and faculty in higher education. Despite deep interest in the effectiveness of these programs in retaining students, scholars have been unable to determine whether such programs have a…

The Early Impact Program: An Early Intervention and Prevention Program for Children and Families At-Risk of Conduct Problems

ERIC Educational Resources Information Center

Larmar, Stephen; Gatfield, Terry

2007-01-01

The Early Impact (EI) program is an early intervention and prevention program for reducing the incidence of conduct problems in pre-school aged children. The EI intervention framework is ecological in design and includes universal and indicated components. This paper delineates key principles and associated strategies that underpin the EI program.…

Thinking Inside the Box: The Health Cube Paradigm for Health and Wellness Program Evaluation and Design

PubMed Central

Harris, Sharon

2013-01-01

Abstract Appropriately constructed health promotions can improve population health. The authors developed a practical model for designing, evaluating, and improving initiatives to provide optimal value. Three independent model dimensions (impact, engagement, and sustainability) and the resultant three-dimensional paradigm were described using hypothetical case studies, including a walking challenge, a health risk assessment survey, and an individual condition management program. The 3-dimensional model is illustrated and the dimensions are defined. Calculation of a 3-dimensional score for program comparisons, refinements, and measurement is explained. Program 1, the walking challenge, had high engagement and impact, but limited sustainability. Program 2, the health risk assessment survey, had high engagement and sustainability but limited impact. Program 3, the on-site condition management program, had measurable impact and sustainability but limited engagement, because of a lack of program capacity. Each initiative, though successful in 2 dimensions, lacked sufficient evolution along the third axis for optimal value. Calculation of a 3-dimensional score is useful for health promotion program development comparison and refinements, and overall measurement of program success. (Population Health Management 2013;16:291–295) PMID:23869538

Evaluation of a peer assessment approach for enhancing the organizational capacity of state injury prevention programs.

PubMed

Hunter, Wanda M; Schmidt, Ellen R; Zakocs, Ronda

2005-01-01

To conduct a formative and pilot impact evaluation of the State Technical Assessment Team (STAT) program, a visitation-based (visitatie) peer assessment program designed to enhance the organizational capacity of state health department injury prevention programs. The formative evaluation was based on observational, record review, and key informant interview data collected during the implementation of the first 7 STAT visits. Pilot impact data were derived from semi-structured interviews with state injury prevention personnel one year after the visit. Formative evaluation identified 6 significant implementation problems in the first visits that were addressed by the program planners, resulting in improvements to the STAT assessment protocol. Impact evaluation revealed that after one year, the 7 state injury prevention programs had acted on 81% of the recommendations received during their STAT visits. All programs reported gains in visibility and credibility within the state health department and increased collaboration and cooperation with other units and agencies. Other significant program advancements were also reported. Specific program standards and review procedures are important to the success of peer assessment programs such as STAT. Early impact evaluation suggests that peer assessment protocols using the visitatie model can lead to gains in organizational capacity.

Methodological Considerations for Use of Routine Health Information System Data to Evaluate Malaria Program Impact in an Era of Declining Malaria Transmission

PubMed Central

Ashton, Ruth A.; Bennett, Adam; Yukich, Joshua; Bhattarai, Achuyt; Keating, Joseph; Eisele, Thomas P.

2017-01-01

Abstract. Coverage of malaria control interventions is increasing dramatically across endemic countries. Evaluating the impact of malaria control programs and specific interventions on health indicators is essential to enable countries to select the most effective and appropriate combination of tools to accelerate progress or proceed toward malaria elimination. When key malaria interventions have been proven effective under controlled settings, further evaluations of the impact of the intervention using randomized approaches may not be appropriate or ethical. Alternatives to randomized controlled trials are therefore required for rigorous evaluation under conditions of routine program delivery. Routine health management information system (HMIS) data are a potentially rich source of data for impact evaluation, but have been underused in impact evaluation due to concerns over internal validity, completeness, and potential bias in estimates of program or intervention impact. A range of methodologies were identified that have been used for impact evaluations with malaria outcome indicators generated from HMIS data. Methods used to maximize internal validity of HMIS data are presented, together with recommendations on reducing bias in impact estimates. Interrupted time series and dose-response analyses are proposed as the strongest quasi-experimental impact evaluation designs for analysis of malaria outcome indicators from routine HMIS data. Interrupted time series analysis compares the outcome trend and level before and after the introduction of an intervention, set of interventions or program. The dose-response national platform approach explores associations between intervention coverage or program intensity and the outcome at a subnational (district or health facility catchment) level. PMID:28990915

Predicting Wanton Assault in a General Youth Sample via the HEW Youth Development Model's Community Program Impact Scales, Age and Sex.

ERIC Educational Resources Information Center

Truckenmiller, James L.

The former HEW National Strategy for Youth Development Model was a community-based planning and procedural tool designed to enhance positive youth development and prevent delinquency through a process of youth needs assessment, development of targeted programs, and program impact evaluation. A series of 12 Impact Scales most directly reflect the…

Using an Experimental Evaluation of Charter Schools to Test Whether Nonexperimental Comparison Group Methods Can Replicate Experimental Impact Estimates. NCEE 2012-4019

ERIC Educational Resources Information Center

Fortson, Kenneth; Verbitsky-Savitz, Natalya; Kopa, Emma; Gleason, Philip

2012-01-01

Randomized controlled trials (RCTs) are widely considered to be the gold standard in evaluating the impacts of a social program. When an RCT is infeasible, researchers often estimate program impacts by comparing outcomes of program participants with those of a nonexperimental comparison group, adjusting for observable differences between the two…

Closing the Education Gender Gap: Estimating the Impact of Girls' Scholarship Program in the Gambia

ERIC Educational Resources Information Center

Gajigo, Ousman

2016-01-01

This paper estimates the impact of a school fee elimination program for female secondary students in The Gambia to reduce gender disparity in education. To assess the impact of the program, two nationally representative household surveys were used (1998 and 2002/2003). By 2002/2003, about half of the districts in the country had benefited from the…

The Impact of Adult Degree-Completion Programs on the Organizational Climate of Christian Colleges and Universities

ERIC Educational Resources Information Center

Giles, Pamela

2010-01-01

Leaders in Christian higher education are often unaware of how adult degree completion programs (ADCPs) impact a school's organizational behavior, and no research has examined employees' perceptions of its impact. This nonexperimental, descriptive study examined differences in employees' perceptions of the impact on organizational climate of the…

77 FR 28623 - Comment Request for Information Collection for the Impact Evaluation of the YouthBuild Program...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-15

..., earnings, and job characteristics? What are YouthBuild's impacts on crime and delinquency? What are the... Collection for the Impact Evaluation of the YouthBuild Program; New Collection AGENCY: Employment and... instruments are clearly understood, and the impact of collection requirements on respondents can be properly...

Preference and Priority in Federal Funding: Aligning Federal Resources to Maximize Program Investment Efficiency and Impacts in Communities

EPA Pesticide Factsheets

This page contains the document, Preference and Priority in Federal Funding: Aligning Federal Resources to Maximize Program Investment Efficiency and Impacts in Communities - Lessons from EPA’s Brownfields Program.

The Impact of an Online Tutoring Program on Mathematics Achievement

ERIC Educational Resources Information Center

Clark, Amy K.; Whetstone, Patti

2014-01-01

The authors explored the impact of an online tutoring program, Math Whizz (Whizz Education, 2014), on student mathematics achievement at 15 elementary schools. Students participated in the use of the Math Whizz program for the duration of the school year as a supplement to mathematics instruction. The Math Whizz program recorded such information…

A Multi-Level Assessment of the Impact of Orientation Programs on Student Learning

ERIC Educational Resources Information Center

Mayhew, Matthew J.; Vanderlinden, Kim; Kim, Eun Kyung

2010-01-01

The purpose of this study was to investigate the influence of orientation programs on student academic and social learning. Moving beyond previous studies, we examined how participation in orientation programming affected student learning and how the impact of these programs on learning varied by organizational characteristics (i.e., institutional…

Developmental Relationship Programs: An Empirical Study of the Impact of Peer-Mentoring Programs

ERIC Educational Resources Information Center

Shojai, Siamack; Davis, William J.; Root, Patricia S.

2014-01-01

This paper provides an empirical analysis of the impact and effectiveness of developmental relationships provided through academic intervention programs at a medium-size master's level public university in the Northeastern United States. The programs' curriculum follows the Model of Strategic Learning's four pillars of learning and is administered…

Knowledge Gaps Impacting the Development of Bovine Viral Diarrhea Virus Control Programs in the United States

USDA-ARS?s Scientific Manuscript database

This paper identifies knowledge gaps that impact on the design of programs to control and or eradicate bovine viral diarrhea viruses (BVDV) in the United States. Currently there are several voluntary regional BVDV control programs in place. These control programs are aimed at the removal of animals ...

District #30 U.S.E.A. Title I Programs--PL 89-10 and Impact Aid Low Rent Housing Programs--PL 81-874. Final Evaluation Report, 1977-1978.

ERIC Educational Resources Information Center

Lesser, Saal D.; Reece, Gene K.

In 1977-78, four remediation programs were funded under Title I and three under Impact Aid in New York City's School District 30. Title I programs included: (1) a teacher-paraprofessional reading team program in 12 elementary, intermediate and junior high schools; (2) a teacher-paraprofessional mathematics team program in 10 elementary,…

Stage I Final Report for the Study of Program Management Procedures in the Campus-Based and Basic Grant Programs. (Volume I).

ERIC Educational Resources Information Center

Puma, Michael J.; And Others

The third phase of SISFAP (Study on the Impact of Student Financial Aid Programs), the primary purpose of this study is to evaluate federal and institutional management policies and practices for Basic Educational Opportunity Grant (BEOG) and campus-based programs as they impact on the extent to which the programs are meeting their legislative…

The Nutritional Impact of the Dairy Price Support Program.

ERIC Educational Resources Information Center

Heien, Dale; Wessells, Cathy Roheim

1988-01-01

Examined the impact of the dairy price support program and its resulting higher prices on nutrition intake, especially calcium. A demand system emphasizing dairy products was estimated. Concluded that nutrient intake would increase substantially if the program was terminated. (JOW)

Calibration of work zone impact analysis software for Missouri.

DOT National Transportation Integrated Search

2013-12-01

This project calibrated two software programs used for estimating the traffic impacts of work zones. The WZ Spreadsheet : and VISSIM programs were recommended in a previous study by the authors. The two programs were calibrated using : field data fro...

Income Transfers and Maternal Health: Evidence from a National Randomized Social Cash Transfer Program in Zambia.

PubMed

Handa, Sudhanshu; Peterman, Amber; Seidenfeld, David; Tembo, Gelson

2016-02-01

There is promising recent evidence that poverty-targeted social cash transfers have potential to improve maternal health outcomes; however, questions remain surrounding design features responsible for impacts. In addition, virtually no evidence exists from the African region. This study explores the impact of Zambia's Child Grant Program on a range of maternal health utilization outcomes using a randomized design and difference-in-differences multivariate regression from data collected over 24 months from 2010 to 2012. Results indicate that while there are no measurable program impacts among the main sample, there are heterogeneous impacts on skilled attendance at birth among a sample of women residing in households having better access to maternal health services. The latter result is particularly interesting because of the overall low level of health care availability in program areas suggesting that dedicated program design or matching supply-side interventions may be necessary to leverage unconditional cash transfers in similar settings to impact maternal health. Copyright © 2015 John Wiley & Sons, Ltd.

Income transfers and maternal health: Evidence from a national randomized social cash transfer program in Zambia

PubMed Central

Handa, Sudhanshu; Peterman, Amber; Seidenfeld, David; Tembo, Gelson

2017-01-01

There is promising recent evidence that poverty-targeted social cash transfers have potential to improve maternal health outcomes, however questions remain surrounding design features responsible for impacts. In addition, virtually no evidence exists from the African region. This study explores the impact of Zambia’s Child Grant Program on a range of maternal health utilization outcomes using a randomized design and difference-in-differences multivariate regression from data collected over 24 months from 2010 to 2012. Results indicate that while there are no measurable program impacts among the main sample, there are heterogeneous impacts on skilled attendance at birth among a sample of women residing in households having better access to maternal health services. The latter result is particularly interesting because of the overall low level of healthcare availability in program areas suggesting dedicated program design or matching supply-side interventions may be necessary to leverage unconditional cash transfers in similar settings to impact maternal health. PMID:25581062

The impact of a national poverty reduction program on the characteristics of sex partners among Kenyan adolescents.

PubMed

Rosenberg, Molly; Pettifor, Audrey; Thirumurthy, Harsha; Halpern, Carolyn Tucker; Handa, Sudhanshu

2014-02-01

Cash transfer programs have the potential to prevent the spread of HIV, particularly among adolescents. One mechanism through which these programs may work is by influencing the characteristics of the people adolescents choose as sex partners. We examined the four-year impact of a Kenyan cash transfer program on partner age, partner enrollment in school, and transactional sex-based relationships among 684 adolescents. We found no significant impact of the program on partner characteristics overall, though estimates varied widely by gender, age, schooling, and economic status. Results highlight the importance of context in exploring the potential HIV preventive effects of cash transfers.

The Impact of a Patient Safety Program on Medical Error Reporting

DTIC Science & Technology

2005-05-01

307 The Impact of a Patient Safety Program on Medical Error Reporting Donald R. Woolever Abstract Background: In response to the occurrence of...a sentinel event—a medical error with serious consequences—Eglin U.S. Air Force (USAF) Regional Hospital developed and implemented a patient safety...communication, teamwork, and reporting. Objective: To determine the impact of a patient safety program on patterns of medical error reporting. Methods: This

Conceptualizing Impact in Academic Development: Finding a Way Through

ERIC Educational Resources Information Center

Jones, Anna; Lygo-Baker, Simon; Markless, Sharon; Rienties, Bart; Di Napoli, Roberto

2017-01-01

This paper explores the notion of impact in the context of academic development programs and considers how it can be described and understood. We argue that impact has a range of meanings and academic development programs such as graduate certificates have a broad group of stakeholders and hence the impact is different for each group depending on…

Wilderness educators' evaluation of the Impact Monster Program

Treesearch

William W. Hendricks; Alan E. Watson

1999-01-01

Since its development by Jim Bradley in the late 1970s, the Impact Monster, a wilderness education skit designed to teach minimum impact techniques, has been used as a wilderness education tool by federal land management agencies. This paper reports on an evaluation of the perceived effectiveness of the Impact Monster program and its content. Results indicate that the...

Impact of solar-energy development. The aggregate impact on basic economic objectives

NASA Astrophysics Data System (ADS)

Parker, A.; Kirschner, C.; Roach, F.

Two categories of incentives for the development of solar energy are described: those that increase the benefits associated with the ownership of a solar energy system and those that reduce the cost of the system. The impact of two alternative programs are presented. Short run and long run impacts expected to result from the installation of passive solar designs on existing housing rock are distinguished. Impacts associated with a program to deregulate natural gas and one combining tax credits and low interest loans are compared. The impacts of solar programs on seven basic economic goals are analyzed. The goals are full employment, price stability, economic efficienty, equitable distribution of income, economic growth, balancing the federal budget, and a strong national defense.

After-School Programs and Academic Impact: A Study of Chicago's After School Matters

ERIC Educational Resources Information Center

Goerge, Robert; Cusick, Gretchen R.; Wasserman, Miriam; Gladden, Matthew

2007-01-01

After-school programs for adolescents may be a way to promote positive youth development, and thus, it is important to understand what impact after-school programs can have on the educational achievement of high school students. Chicago's After School Matters (ASM) program offers an exceptional opportunity to study whether an after-school program…

Bright Ideas That Work: A Booklet of School Programs That Impact Minority and Equity Issues.

ERIC Educational Resources Information Center

North Carolina State Dept. of Public Instruction, Raleigh. Div. of Desegregation Assistance.

This directory describes 25 innovative programs, in the public schools of North Carolina, which impact minority and equity issues. The following information is supplied for each program: (1) contact person; (2) grade level; (3) purpose; and (4) nature and scope. The following programs are located in the Charlotte-Mecklenberg Schools: (1) After…

The Impact of a Sport-Based Life Skill Program on Adolescent Prosocial Values

ERIC Educational Resources Information Center

Brunelle, John; Danish, Steven J.; Forneris, Tanya

2007-01-01

This article describes the implementation and evaluation of a sport-based life skills and community service program. The purpose of this investigation was to determine the impact of a combined life skills and community service program on adolescents' prosocial values. The program was part of a national golf and life skills enrichment academy for…

The CAEP Standards and Research on Educator Preparation Programs: Linking Clinical Partnerships with Program Impact

ERIC Educational Resources Information Center

Heafner, Tina; McIntyre, Ellen; Spooner, Melba

2014-01-01

Responding to the challenge of more rigorous and outcome-oriented program evaluation criteria of the Council for the Accreditation of Educator Preparation (CAEP), authors take a critical look at the intersection of two standards: Clinical Partnerships and Practice (Standard 2) and Program Impact (Standard 4). Illustrating one aspect of a secondary…

The Impact of Federal Early Childhood Programs on Children.

ERIC Educational Resources Information Center

Hertz, Thomas W.

This paper reviews research findings concerning the effects on young children of major Federal programs in education and child care. It offers a summary rather than a detailed view of research on the impact of programs, and is based primarily on major program evaluation reports and research reviews. In addition, it draws upon a small number of…

Training That Works: Lessons from California's Employment Training Panel Program.

ERIC Educational Resources Information Center

Moore, Richard W.; Blake, Daniel R.; Phillips, G. Michael; McConaughy, Daniel

California's Employment Training Panel Program (ETP), the largest state-funded customized training program for incumbent workers in the nation, has had a positive impact on the economy of California, and its success has policy implications for other state programs. The impact of ETP on trainees includes the following: they are more attached to the…

Teacher Social Capital and Student Achievement: Impact of a Cyber-Enabled Teacher Professional Development Program

ERIC Educational Resources Information Center

Liu, Wei

2012-01-01

This is an evaluative research study of a NSF-funded, DRK-12 cyber-enabled teacher professional development program in elementary engineering education. The finding shows the significant impact of the program on students' science and engineering knowledge in the second year of the program's implementation. However, student learning gain…

Safety Analysis and Industry Impacts of the Pre-Employment Screening Program (PSP)

DOT National Transportation Integrated Search

2013-10-01

In this report, FMCSA analyzes the safety impacts of the Pre-Employment Screening Program (PSP) and presents metrics and anecdotal information on attitudes of carriers using PSP. The safety impacts are examined by comparing the crash rates and driver...

76 FR 23712 - Impact Aid Programs

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-28

... certain eligible local educational agencies (LEAs) that receive Impact Aid formula funds. These final regulations amend a requirement for applying for these Impact Aid funds and will improve the administration... provide early notification of our specific plans and actions for this program. Assessment of Educational...

National Weatherization Assistance Program Impact Evaluation: Impact of Exhaust-Only Ventilation on Radon and Indoor Humidity - A Field Investigation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pigg, Scott

2014-09-01

The study described here sought to assess the impact of exhaust-only ventilation on indoor radon and humidity in single-family homes that had been treated by the Weatherization Assistance Program (WAP).

Measurement of the top pair production cross section in 8 TeV proton-proton collisions using kinematic information in the lepton + jets final state with ATLAS

DOE PAGES

Aad, G.; Abbott, B.; Abdallah, J.; ...

2015-06-24

A measurement is presented of the tmore » $$\\bar{t}$$ inclusive production cross section in pp collisions at a center-of-mass energy of √s=8 TeV using data collected by the ATLAS detector at the CERN Large Hadron Collider. Our measurement was performed in the lepton þ jets final state using a data set corresponding to an integrated luminosity of 20.3 fb -1. Then, the cross section was obtained using a likelihood discriminant fit and b-jet identification was used to improve the signal-to-background ratio. The inclusive t$$\\bar{t}$$ production cross section was measured to be 260 ± 1(stat)$$+22\\atop{-23}$$(stat) ± 8(lum9) ± 4(beam) pb assuming a top-quark mass of 172.5 GeV, in good agreement with the theoretical prediction of 253$$+13\\atop{-15}$$ pb. The t$$\\bar{t}$$ → (e, μ) + jets production cross section in the fiducial region determined by the detector acceptance is also reported.« less

Rapid detection of α-thalassaemia alleles of --(SEA)/, -α(3.7)/ and -α(4.2)/ using a dual labelling, self-quenching hybridization probe/melting curve analysis.

PubMed

Gao, Lan; Liu, Yanhui; Sun, Manna; Zhao, Ying; Xie, Rungui; He, Yi; Xu, Wanfang; Liu, Jianxin; Lin, Yangyang; Lou, Jiwu

2015-12-01

The aim of the study was to set up an alternative automatic molecular diagnostic method for deletional α-thalassaemia mutations without gel electrophoresis. Based on the sequence variation within the two Z boxes and melting curve analysis of dually labelled probes, a real-time PCR assay was developed and validated for the rapid detection of major α-genotypes (--(SEA)/αα, --(SEA)/-α(3.7), --(SEA)/-α(4.2), --(SEA)/--(SEA), -α(3.7)/-α(3.7) and -α(4.2)/-α(4.2)). Samples with the -α(3.7)/-α(3.7), -α(4.2)/-α(4.2), --(SEA)/αα, --(SEA)/-α(3.7), --(SEA)/-α(4.2), and --(SEA)/--(SEA) genotypes could be clearly distinguished. The accuracy of this technique for these samples was 100% sensitivity and specificity. This technique is rapid and reliable, demonstrating feasibility for use in large-scale population screening and prenatal diagnosis of deletional Hb H disease and Hb Bart's hydrops fetalis. Copyright © 2015 Elsevier Ltd. All rights reserved.

In pursuit of excellence: an integrated care pathway for C1 inhibitor deficiency

PubMed Central

Manson, A L; Price, A; Dempster, J; Clinton-Tarestad, P; Greening, C; Enti, R; Hill, S; Grigoriadou, S; Buckland, M S; Longhurst, H J

2013-01-01

There are estimated to be approximately 1500 people in the United Kingdom with C1 inhibitor (C1INH) deficiency. At BartsHealth National Health Service (NHS) Trust we manage 133 patients with this condition and we believe that this represents one of the largest cohorts in the United Kingdom. C1INH deficiency may be hereditary or acquired. It is characterized by unpredictable episodic swellings, which may affect any part of the body, but are potentially fatal if they involve the larynx and cause significant morbidity if they involve the viscera. The last few years have seen a revolution in the treatment options that are available for C1 inhibitor deficiency. However, this occurs at a time when there are increased spending restraints in the NHS and the commissioning structure is being overhauled. Integrated care pathways (ICP) are a tool for disseminating best practice, for facilitating clinical audit, enabling multi-disciplinary working and for reducing health-care costs. Here we present an ICP for managing C1 inhibitor deficiency. PMID:23607500

Measurement of Spin Correlation in Top-Antitop Quark Events and Search for Top Squark Pair Production in p p Collisions at s = 8 TeV Using the ATLAS Detector

DOE PAGES

Aad, G.; Abbott, B.; Abdallah, J.; ...

2015-04-08

We present a measurement of spin correlation in tmore » $$\\bar{t}$$ production using data collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 20.3 fb ₋1. The correlation between the top and antitop quark spins is extracted from dilepton t$$\\bar{t}$$ events by using the difference in the azimuthal angle between the two charged leptons in the laboratory frame. In the helicity basis the measured degree of correlation corresponds to A helicity = 0.38±0.04, in agreement with the standard model prediction. A search is performed for pair production of top squarks with masses close to the top quark mass decaying to predominantly right-handed top quarks and a light neutralino, the lightest supersymmetric particle. Lastly, top squarks with masses between the top quark mass and 191 GeV are excluded at the 95% confidence level.« less

Inclusive and differential measurements of the $$\\mathrm{ t \\bar{t} }$$ charge asymmetry in pp collisions at $$\\sqrt{s} =$$ 8 TeV

DOE PAGES

Khachatryan, Vardan

2016-03-29

The tt charge asymmetry is measured in proton-proton collisions at a centre-of-mass energy of 8 TeV. The data, collected with the CMS experiment at the LHC, correspond to an integrated luminosity of 19.7 fb -1 . Selected events contain an electron or a muon and four or more jets, where at least one jet is identified as originating from b-quark hadronization. The inclusive charge asymmetry is found to be 0.0010 ± 0.0068 (stat) ± 0.0037 (syst). In addition, differential charge asymmetries as a function of rapidity, transverse momentum, and invariant mass of the tt system are studied. For the firstmore » time at the LHC, our measurements are also performed in a reduced fiducial phase space of top quark pair production, with an integrated result of -0.0035 ± 0.0072 (stat) ± 0.0031 (syst). Additionally, all measurements are consistent within two standard deviations with zero asymmetry as well as with the predictions of the standard model.« less

Hb Dartmouth (HBA2: c.200T>C): An α2-Globin Gene Associated with Hb H Disease in One Homozygous Patient.

PubMed

Farashi, Samaneh; Faramarzi Garous, Negin; Ashki, Mehri; Vakili, Shadi; Zeinali, Fatemah; Imanian, Hashem; Azarkeivan, Azita; Najmabadi, Hossein

2015-01-01

Hb H (β4) disease is caused by deletion or inactivation of three out of four α-globin genes. A high incidence of Hb H disease has been reported all over the world. There is a wide spectrum of phenotypic presentations, from clinically asymptomatic to having significant hepatosplenomegaly and requiring occasional or even regular blood transfusions, even more severe anemia, Hb Bart's (γ4) hydrops fetalis syndrome that can cause death in the affected fetuses late in gestation. We here present a case who was diagnosed with Hb H disease that represents a new genotype for this hereditary disorder. Hb Dartmouth is a variant caused by a missense mutation at codon 66 of the α2-globin gene (HBA2: c.200T>C), resulting in the substitution of leucine by proline. We here emphasize the importance of this point mutation involving Hb H disease and also the necessity for prenatal diagnosis (PND) for those who carry this point mutation in the heterozygous state.

Pathobiologic Roles of Epstein–Barr Virus-Encoded MicroRNAs in Human Lymphomas

PubMed Central

Navari, Mohsen; Etebari, Maryam; Ibrahimi, Mostafa; Leoncini, Lorenzo

2018-01-01

Epstein–Barr virus (EBV) is a human γ-herpesvirus implicated in several human malignancies, including a wide range of lymphomas. Several molecules encoded by EBV in its latent state are believed to be related to EBV-induced lymphomagenesis, among which microRNAs—small RNAs with a posttranscriptional regulating role—are of great importance. The genome of EBV encodes 44 mature microRNAs belonging to two different classes, including BamHI-A rightward transcript (BART) and Bam HI fragment H rightward open reading frame 1 (BHRF1), with different expression levels in different EBV latency types. These microRNAs might contribute to the pathogenetic effects exerted by EBV through targeting self mRNAs and host mRNAs and interfering with several important cellular mechanisms such as immunosurveillance, cell proliferation, and apoptosis. In addition, EBV microRNAs can regulate the surrounding microenvironment of the infected cells through exosomal transportation. Moreover, these small molecules could be potentially used as molecular markers. In this review, we try to present an updated and extensive view of the role of EBV-encoded miRNAs in human lymphomas. PMID:29649101

Top quark mass measurement using the template method at CDF

DOE PAGES

Aaltonen, T

2011-06-03

We present a measurement of the top quark mass in the lepton+jets and dilepton channels of tmore » $$\\bar{t}$$ decays using the template method. The data sample corresponds to an integrated luminosity of 5.6 fb -1 of p$$\\bar{p}$$ collisions at Tevatron with √s = 1.96 TeV, collected with the CDF II detector. The measurement is performed by constructing templates of three kinematic variables in the lepton+jets and two kinematic variables in the dilepton channel. The variables are two reconstructed top quark masses from different jets-to-quarks combinations and the invariant mass of two jets from the W decay in the lepton+jets channel, and a reconstructed top quark mass and m T2, a variable related to the transverse mass in events with two missing particles, in the dilepton channel. The simultaneous fit of the templates from signal and background events in the lepton+jets and dilepton channels to the data yields a measured top quark mass of M top = 172.1±1.1 (stat)±0.9 (syst) GeV/c 2.« less

A measurement of the t anti-t production cross-section in proton anti-proton collisions at √s = 1.96-TeV with the D0 detector at the Tevatron using final states with a muon and jets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klute, Markus

A preliminary measurement of the tmore » $$\\bar{t}$$ production cross section at √s = 1.96 TeV is presented. The μ-plus-jets final state is analyzed in a data sample of 94 pb -1 and a total of 14 events are selected with a background expectation of 11.7 ± 1.9 events. The measurement yields: σ p$$\\bar{p}$$ → t$$\\bar{t}$$ + X} = 2.4$$+4.2\\atop{-3.5}$$(stat.)$$+2.5\\atop{-2.6}$$(syst.) ± 0.3(lumi.) pb. The analysis, being part of a larger effort to re-observe the top quark in Tevatron Run II data and to measure the production cross section, is combined with results from all available analyses channels. The combined result yields: σ p$$\\bar{p}$$ → t$$\\bar{t}$$ + X = 8.1$$+2.2\\atop{-2.0}$$(stat.)$$+1.6\\atop{-1.4}$$(syst.) ± 0.8(lumi.) pb.« less

Designing programs to improve diets for maternal and child health: estimating costs and potential dietary impacts of nutrition-sensitive programs in Ethiopia, Nigeria, and India.

PubMed

Masters, William A; Rosettie, Katherine L; Kranz, Sarah; Danaei, Goodarz; Webb, Patrick; Mozaffarian, Dariush

2018-05-01

Improving maternal and child nutrition in resource-poor settings requires effective use of limited resources, but priority-setting is constrained by limited information about program costs and impacts, especially for interventions designed to improve diet quality. This study utilized a mixed methods approach to identify, describe and estimate the potential costs and impacts on child dietary intake of 12 nutrition-sensitive programs in Ethiopia, Nigeria and India. These potential interventions included conditional livestock and cash transfers, media and education, complementary food processing and sales, household production and food pricing programs. Components and costs of each program were identified through a novel participatory process of expert regional consultation followed by validation and calibration from literature searches and comparison with actual budgets. Impacts on child diets were determined by estimating of the magnitude of economic mechanisms for dietary change, comprehensive reviews of evaluations and effectiveness for similar programs, and demographic data on each country. Across the 12 programs, total cost per child reached (net present value, purchasing power parity adjusted) ranged very widely: from 0.58 to 2650 USD/year among five programs in Ethiopia; 2.62 to 1919 USD/year among four programs in Nigeria; and 27 to 586 USD/year among three programs in India. When impacts were assessed, the largest dietary improvements were for iron and zinc intakes from a complementary food production program in Ethiopia (increases of 17.7 mg iron/child/day and 7.4 mg zinc/child/day), vitamin A intake from a household animal and horticulture production program in Nigeria (335 RAE/child/day), and animal protein intake from a complementary food processing program in Nigeria (20.0 g/child/day). These results add substantial value to the limited literature on the costs and dietary impacts of nutrition-sensitive interventions targeting children in resource-limited settings, informing policy discussions and serving as critical inputs to future cost-effectiveness analyses focusing on disease outcomes.

Designing programs to improve diets for maternal and child health: estimating costs and potential dietary impacts of nutrition-sensitive programs in Ethiopia, Nigeria, and India

PubMed Central

Rosettie, Katherine L; Kranz, Sarah; Danaei, Goodarz; Webb, Patrick; Mozaffarian, Dariush; Bhattacharjee, Lalita; Chandrasekhar, S; Christensen, Cheryl; Desai, Sonalde; Kazi-Hutchins, Nabeeha; Levin, Carol; Paarlberg, Robert; Vosti, Steven; Adekugbe, Olayinka; Atomsa, Gudina Egata; Badham, Jane; Baye, Kaleab; Beyero, Mesfin; Covic, Namukolo; Dalton, Babukiika; Dufour, Charlotte; Fracassi, Patrizia; Getahun, Zewditu; Haidar, Jemal; Hailu, Tesfaye; Kebede, Aweke; Kinabo, Joyce; Kussaga, Jamal Bakari; Mavrotas, George; Mwanja, Wilson Waiswa; Oguntona, Babatunde; Oladipo, Abiodun; Oniang’o, Ruth; Sibanda, Simbarashe; Sodjinou, Roger; Tom, Carol; Wamani, Henry; Wendelin, Akwilina; Adhikari, Ramesh Kant; Amatya, Archana; Bhattarai, Manav; Brahmbhatt, Viral; Chandyo, Ram Krishna; Gulati, Seema; Kapil, Umesh; Mehta, Ranju; Mohan, Sailesh; Prabhakaran, D; Prakash, V; Puri, Seema; Roy, S K; Sharma, Rekha; Shivakoti, Sabnam; Thorne-Lyman, Andrew; Rana, Pooja Pandey; Trilok-Kumar, Geeta

2018-01-01

Abstract Improving maternal and child nutrition in resource-poor settings requires effective use of limited resources, but priority-setting is constrained by limited information about program costs and impacts, especially for interventions designed to improve diet quality. This study utilized a mixed methods approach to identify, describe and estimate the potential costs and impacts on child dietary intake of 12 nutrition-sensitive programs in Ethiopia, Nigeria and India. These potential interventions included conditional livestock and cash transfers, media and education, complementary food processing and sales, household production and food pricing programs. Components and costs of each program were identified through a novel participatory process of expert regional consultation followed by validation and calibration from literature searches and comparison with actual budgets. Impacts on child diets were determined by estimating of the magnitude of economic mechanisms for dietary change, comprehensive reviews of evaluations and effectiveness for similar programs, and demographic data on each country. Across the 12 programs, total cost per child reached (net present value, purchasing power parity adjusted) ranged very widely: from 0.58 to 2650 USD/year among five programs in Ethiopia; 2.62 to 1919 USD/year among four programs in Nigeria; and 27 to 586 USD/year among three programs in India. When impacts were assessed, the largest dietary improvements were for iron and zinc intakes from a complementary food production program in Ethiopia (increases of 17.7 mg iron/child/day and 7.4 mg zinc/child/day), vitamin A intake from a household animal and horticulture production program in Nigeria (335 RAE/child/day), and animal protein intake from a complementary food processing program in Nigeria (20.0 g/child/day). These results add substantial value to the limited literature on the costs and dietary impacts of nutrition-sensitive interventions targeting children in resource-limited settings, informing policy discussions and serving as critical inputs to future cost-effectiveness analyses focusing on disease outcomes. PMID:29522103

The Impact of the Louisiana Scholarship Program on Racial Segregation in Louisiana Schools. Louisiana Scholarship Program Evaluation Report #3. Technical Report

ERIC Educational Resources Information Center

Egalite, Anna J.; Mills, Jonathan N.; Wolf, Patrick J.

2016-01-01

The question of how school choice programs affect the racial stratification of schools is highly salient in the field of education policy. We use a student-level panel data set to analyze the impacts of the Louisiana Scholarship Program (LSP) on racial segregation in public and private schools. This targeted school voucher program provides funding…

Programs to Strengthen Parent-Adolescent Communication About Reproductive Health: A Systematic Review.

PubMed

Gavin, Loretta E; Williams, Jessica R; Rivera, Maria I; Lachance, Christina R

2015-08-01

When caring for an adolescent client, providers of contraceptive services must consider whether and how to encourage parent/guardian-child communication about the adolescent's reproductive health. The objective of this systematic review was to summarize the evidence on the effectiveness of programs designed to increase parent-child communication about reproductive health. The review was used to inform national recommendations on quality family planning services. Data analysis occurred from mid-2011 through 2012. Several electronic bibliographic databases were used to identify relevant articles, including PubMed, CINAHL, PsycINFO, and Popline, published from January 1985 through February 2011. Sixteen articles met the inclusion criteria: all studies examined the impact on at least one medium- or short-term outcome, and two studies assessed the impact on teen pregnancy. One study examined the impact of a program conducted in a clinic setting; the remainder examined the impact of programs in community settings. All studies showed a positive impact on at least one short-term outcome, and 12 of 16 studies showed an increase in parent-child communication about reproductive health. Four of seven studies found an impact on sexual risk behavior. Most programs increased parent-child communication, and several resulted in reduced sexual risk behavior of adolescents. This suggests that delivering a clinic-based program that effectively helps parents/guardians talk to their adolescent child(ren) about reproductive health, or referring parents/guardians to an evidence-based program in the community, may be beneficial. However, further rigorous research on delivery of these programs in clinical settings is needed. Published by Elsevier Inc.

Internet-based peer support for Ménière's disease: a summary of web-based data collection, impact evaluation, and user evaluation.

PubMed

Pyykkő, Ilmari; Manchaiah, Vinaya; Levo, Hilla; Kentala, Erna; Juhola, Martti

2017-07-01

This paper presents a summary of web-based data collection, impact evaluation, and user evaluations of an Internet-based peer support program for Ménière's disease (MD). The program is written in html-form. The data are stored in a MySQL database and uses machine learning in the diagnosis of MD. The program works interactively with the user and assesses the participant's disorder profile in various dimensions (i.e., symptoms, impact, personal traits, and positive attitude). The inference engine uses a database to compare the impact with 50 referents, and provides regular feedback to the user. Data were analysed using descriptive statistics and regression analysis. The impact evaluation was based on 740 cases and the user evaluation on a sample of 75 cases of MD respectively. The web-based system was useful in data collection and impact evaluation of people with MD. Among those with a recent onset of MD, 78% rated the program as useful or very useful, whereas those with chronic MD rated the program 55%. We suggest that a web-based data collection and impact evaluation for peer support can be helpful while formulating the rehabilitation goals of building the self-confidence needed for coping and increasing social participation.

Financial impact of population health management programs: reevaluating the literature.

PubMed

Grossmeier, Jessica; Terry, Paul E; Anderson, David R; Wright, Steven

2012-06-01

Although many employers offer some components of worksite-based population health management (PHM), most do not yet invest in comprehensive programs. This hesitation to invest in comprehensive programs may be attributed to numerous factors, such as other more pressing business priorities, reluctance to intervene in the personal health choices of employees, or insufficient funds for employee health. Many decision makers also remain skeptical about whether investment in comprehensive programs will produce a financial return on investment (ROI). Most peer-reviewed studies assessing the financial impact of PHM were published before 2000 and include a broad array of program and study designs. Many of these studies have also included indirect productivity savings in their assessment of financial outcomes. In contrast, this review includes only peer-reviewed studies of the direct health care cost impact of comprehensive PHM programs that meet rigorous methodological criteria. A systematic search of health sciences databases identified only 5 studies with program designs and study methods meeting these selection criteria published after 2007. This focused review found that comprehensive PHM programs can yield a positive ROI based on their impact on direct health care costs, but the level of ROI achieved was lower than that reported by literature reviews with less focused and restrictive qualifying criteria. To yield substantial short-term health care cost savings, the longer term financial return that can credibly be associated with a comprehensive, prevention-oriented population health program must be augmented by other financial impact strategies.

28 CFR 91.54 - Applicability.

Code of Federal Regulations, 2010 CFR

2010-07-01

... major federal action that might significantly impact the quality of the human environment. The CEQ... activities that may significantly impact the environment. (c) Projects. Although VOI/TIS money cannot be used... Impact Review Procedures for VOI/TIS Grant Program Application to Voi/tis Grant Program § 91.54...

78 FR 50022 - Environmental Impact Statement; Asian Longhorned Beetle Eradication Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-16

... submit comments regarding the environmental impact statement by either of the following methods: Federal..., Environmental Protection Specialist, Environmental and Risk Analysis Services, PPD, APHIS, 4700 River Road Unit...] Environmental Impact Statement; Asian Longhorned Beetle Eradication Program AGENCY: Animal and Plant Health...

ENVIRONMENTAL, ECONOMIC AND ENERGY IMPACTS OF MATERIAL RECOVERY FACILITIES - A MITE PROGRAM EVALUATION

EPA Science Inventory

This report documents an evaluation of the environmental, economic, and energy impacts of material recovery facilities (MRFS) conducted under the Municipal Solid Waste Innovative Technology Evaluation (MITE) Program. he MITE Program is sponsored by the U.S. Environmental Protecti...

The Social and Productive Impacts of Zambia's Child Grant.

PubMed

Handa, Sudhanshu; Seidenfeld, David; Davis, Benjamin; Tembo, Gelson

2016-01-01

Accumulated evidence from dozens of cash transfer programs across the world suggest that there are few interventions that can match the range of impacts and cost-effectiveness of a small, predictable monetary transfer to poor families in developing countries. However, individual published impact assessments typically focus on only one program and one outcome. This article presents two-year impacts of the Zambian Government's Child Grant, an unconditional cash transfer to families with children under age five, across a wide range of domains including consumption, productive activity and women and children's outcomes, making this one of the first studies to assess both protective and productive impacts of a national unconditional cash transfer program. We show strong impacts on consumption, food security, savings and productive activity. However, impacts in areas such as child nutritional status and schooling depend on initial conditions of the household, suggesting that cash alone is not enough to solve all constraints faced by these poor, rural households. Nevertheless, the apparent transformative effects of this program suggest that unconditional transfers in very poor settings can contribute to both protection and development outcomes.

Program of policy studies in science and technology

NASA Technical Reports Server (NTRS)

Mayo, L. H.

1973-01-01

The application of an interdisciplinary, problem-oriented capability to the performance of total social impact evaluations is discussed. The consequences of introducing new configurations, technological or otherwise into future social environments are presented. The primary characteristics of the program are summarized: (1) emphasis on interdisciplinary, problem-oriented analysis; (2) development of intra- and inter-institutional arrangements for the purpose of analyzing social problems, evaluating existing programs, and assessing the social impacts of prospective policies, programs, and other public actions; (3) focus on methodological approaches to the projection of alternative future social environments, the identification of the effects of the introduction of new policies, programs, or other actions into the social system, and the evaluation of the social impacts of such effects; (4) availability of analytical resources for advisory and research tasks, and provision for use of program facilities as a neutral forum for the discussion of public issues involving involving the impact of advancing technology on social value-institutional processes.

Reaching out to high school youth: the effectiveness of a video-based antistigma program.

PubMed

Stuart, Heather

2006-09-01

To evaluate the impact on high school students of a video-based antistigma program portraying real life experiences of individuals with schizophrenia and lesson plans to guide classroom discussions and active learning. We used a pre- and posttest design to measure the short-term impact of the program on student's knowledge of schizophrenia and its treatment as well as students' self-reported socially distancing behaviours. Participants (571 students) were from 8 high schools across Canada. Following the Reaching Out antistigma program, high school students were significantly more knowledgeable and less socially distancing. Impact also varied by age group and sex. Video-based antistigma programs are comparable to programs that deliver educational messages through direct contact with individuals with mental illnesses. Video-based programs are more easily disseminated on a broad scale.

Methods and challenges for the health impact assessment of vaccination programs in Latin America.

PubMed

Sartori, Ana Marli Christovam; Nascimento, Andréia de Fátima; Yuba, Tânia Yuka; Soárez, Patrícia Coelho de; Novaes, Hillegonda Maria Dutilh

2015-01-01

To describe methods and challenges faced in the health impact assessment of vaccination programs, focusing on the pneumococcal conjugate and rotavirus vaccines in Latin America and the Caribbean. For this narrative review, we searched for the terms "rotavirus", "pneumococcal", "conjugate vaccine", "vaccination", "program", and "impact" in the databases Medline and LILACS. The search was extended to the grey literature in Google Scholar. No limits were defined for publication year. Original articles on the health impact assessment of pneumococcal and rotavirus vaccination programs in Latin America and the Caribbean in English, Spanish or Portuguese were included. We identified 207 articles. After removing duplicates and assessing eligibility, we reviewed 33 studies, 25 focusing on rotavirus and eight on pneumococcal vaccination programs. The most frequent studies were ecological, with time series analysis or comparing pre- and post-vaccination periods. The main data sources were: health information systems; population-, sentinel- or laboratory-based surveillance systems; statistics reports; and medical records from one or few health care services. Few studies used primary data. Hospitalization and death were the main outcomes assessed. Over the last years, a significant number of health impact assessments of pneumococcal and rotavirus vaccination programs have been conducted in Latin America and the Caribbean. These studies were carried out few years after the programs were implemented, meet the basic methodological requirements and suggest positive health impact. Future assessments should consider methodological issues and challenges arisen in these first studies conducted in the region.

Using insects for STEM outreach: Development and evaluation of the UA Insect Discovery Program

NASA Astrophysics Data System (ADS)

Beal, Benjamin D.

Science and technology impact most aspects of modern daily life. It is therefore important to create a scientifically literate society. Since the majority of Americans do not take college-level science courses, strong K-12 science education is essential. At the K-5 level, however, many teachers lack the time, resources and background for effective science teaching. Elementary teachers and students may benefit from scientist-led outreach programs created by Cooperative Extension or other institutions. One example is the University of Arizona Insect Discovery Program, which provides short-duration programing that uses insects to support science content learning, teach critical thinking and spark interest in science. We conducted evaluations of the Insect Discovery programming to determine whether the activities offered were accomplishing program goals. Pre-post tests, post program questionnaires for teachers, and novel assessments of children's drawings were used as assessment tools. Assessments were complicated by the short duration of the program interactions with the children as well as their limited literacy. In spite of these difficulties, results of the pre-post tests indicated a significant impact on content knowledge and critical thinking skills. Based on post-program teacher questionnaires, positive impacts on interest in science learning were noted as much as a month after the children participated in the program. New programming and resources developed to widen the potential for impact are also described.

Impacts of abstinence education on teen sexual activity, risk of pregnancy, and risk of sexually transmitted diseases.

PubMed

Trenholm, Christopher; Devaney, Barbara; Fortson, Kenneth; Clark, Melissa; Bridgespan, Lisa Quay; Wheeler, Justin

2008-01-01

This paper examines the impacts of four abstinence-only education programs on adolescent sexual activity and risks of pregnancy and sexually transmitted diseases (STDs). Based on an experimental design, the impact analysis uses survey data collected in 2005 and early 2006 from more than 2,000 teens who had been randomly assigned to either a program group that was eligible to participate in one of the four programs or a control group that was not. The findings show no significant impact on teen sexual activity, no differences in rates of unprotected sex, and some impacts on knowledge of STDs and perceived effectiveness of condoms and birth control pills

Human Services Program Evaluation: "How to Improve Your Accountability and Program Effectiveness"

ERIC Educational Resources Information Center

Barrett, Thomas; Sorensen, James

2015-01-01

The term "outcome evaluation" has become one of the most popular terms among human service providers and those whose job it is to evaluate the impact of human service programs. In the public sector alone, there are over a hundred instruments in use to evaluate the impact of state human service programs. Most states, many providers, and…

An Analysis of the Neighborhood Impacts of a Mortgage Assistance Program: A Spatial Hedonic Model

ERIC Educational Resources Information Center

Di, Wenhua; Ma, Jielai; Murdoch, James C.

2010-01-01

Down payment or closing cost assistance is an effective program in addressing the wealth constraints of low-and moderate-income homebuyers. However, the spillover effect of such programs on the neighborhood is unknown. This paper estimates the impact of the City of Dallas Mortgage Assistance Program (MAP) on nearby home values using a hedonic…

An Assessment of the Impact of a Science Outreach Program, Science In Motion, on Student Achievement, Teacher Efficacy, and Teacher Perception

ERIC Educational Resources Information Center

Herring, Phillip Allen

2009-01-01

The purpose of the study was to analyze the science outreach program, Science In Motion (SIM), located in Mobile, Alabama. This research investigated what impact the SIM program has on student cognitive functioning and teacher efficacy and also investigated teacher perceptions and attitudes regarding the program. To investigate student…

Growing Community: The Impact of the Stephanie Alexander Kitchen Garden Program on the Social and Learning Environment in Primary Schools

ERIC Educational Resources Information Center

Block, Karen; Gibbs, Lisa; Staiger, Petra K.; Gold, Lisa; Johnson, Britt; Macfarlane, Susie; Long, Caroline; Townsend, Mardie

2012-01-01

This article presents results from a mixed-method evaluation of a structured cooking and gardening program in Australian primary schools, focusing on program impacts on the social and learning environment of the school. In particular, we address the Stephanie Alexander Kitchen Garden Program objective of providing a pleasurable experience that has…

Impact Evaluation of the U.S. Department of Education's Student Mentoring Program. Final Report. NCEE 2009-4047

ERIC Educational Resources Information Center

Bernstein, Lawrence; Rappaport, Catherine Dun; Olsho, Lauren; Hunt, Dana; Levin, Marjorie

2009-01-01

This report summarizes the findings from a national evaluation of mentoring programs funded under the U.S. Department of Education's Student Mentoring Program. The impact evaluation used an experimental design in which students were randomly assigned to a treatment or control group. Thirty-two purposively selected School Mentoring Programs and…

The Impact of Personal and Program Characteristics on the Placement of School Leadership Preparation Program Graduates in School Leader Positions

ERIC Educational Resources Information Center

Fuller, Edward J.; Hollingworth, Liz; An, Brian P.

2016-01-01

Purpose: The purpose of this study is to examine the impact of personal and program characteristics on the placement of graduates of principal preparation programs in assistant principal, principal, and school leadership positions. Research Design: This study relies on Texas principal production data from 1993 through 2007 matched to employment…

Confessions of Former Teen Program Participants: Two Decades Later

ERIC Educational Resources Information Center

Flores, Fabrizio; Wyrick, Gabrielle; Zwicky, Calder

2014-01-01

As a companion to more data-driven articles and studies that consider the long-term impact of art museum teen programs on alumni, this article takes the form of a person to person interview with two founding teen members of important programs that emerged in the 1990s. Talking candidly about the impact of their program participation, Calder Zwicky…

Determining the Quality and Impact of an E-Mentoring Program on At-Risk Youth

ERIC Educational Resources Information Center

Culpepper, Diane W.; Hernandez-Gantes, Victor M.; Blank, William E.

2015-01-01

The purpose of this study was to determine the quality of an e-mentoring program and the impact of participation on at-risk high school students enrolled in dropout prevention programs. The quality of the program was evaluated based on the ease of implementation, use of technology, and overall satisfaction. Indicators of student's self-esteem,…

Evaluation of the Initial Impacts of the National Science Foundation's Integrative Graduate Education and Research Traineeship Program: Final Report

ERIC Educational Resources Information Center

Carney, Jennifer; Chawla, Deepika; Wiley, Autumn; Young, Denise

2006-01-01

This report summarizes findings from an evaluation of the impacts of the National Science Foundation's (NSF) Integrative Graduate Education and Research Traineeships (IGERT) program. Through support of interdisciplinary graduate education programs in Science, Technology, Engineering, and Mathematics, the IGERT program aims to educate U.S.…

YA4-H! Youth Advocates for Health: Impact of a 4-H Teens-as-Teachers Program

ERIC Educational Resources Information Center

Arnold, Mary E.; Flesch, Jeffrey M.; Ashton, Carolyn; Black, Lynette; Brody, Barbara; Hosty, Maureen; Northway, Shanna

2016-01-01

This article reports the results of an evaluation of the YA4-H! Youth Advocates for Health--Teens as Teachers program. Consistent with previous research on the impact of teen teaching, the teens participating in the program gained confidence and skill with regard to teaching younger youths. The program also affected the teens' understanding that…

Delving into Alumni Perceptions about the Impact and Effectiveness of Two Certificate Programs: Meeting Their Mission?

ERIC Educational Resources Information Center

Johnson, Tristan E.; Yukselturk, Erman; Top, Ercan

2014-01-01

The purpose of the study was to analyze two certificate programs in regard to the impacts on alumni professional career and strengths and weaknesses of certificate programs in the views of their alumni. The sample consisted of 58 participants who completed one of the certificate programs. The results showed that alumni rated self-improvement as…

The Impact of a Three-Week Summer Reading Program on Students' Oral Reading Fluency

ERIC Educational Resources Information Center

Juilfs, Kelly

2014-01-01

The impacts of a summer reading program on students' reading fluency were assessed. Fifteen students in grades first through seventh voluntarily attended a nine-day summer reading program. Participants who attended the program were a good representation of the other students in the school. The school was selected due to the high percentage of…

The Impact of Patient-Centered versus Didactic Education Programs in Chronic Patients by Severity: The Case of Type 2 Diabetes Mellitus.

PubMed

Windrum, Paul; García-Goñi, Manuel; Coad, Holly

2016-06-01

Education leads to better health-related decisions and protective behaviors, being especially important for patients with chronic conditions. Self-management education programs have been shown to be beneficial for patients with different chronic conditions and to have a higher impact on health outcomes than does didactic education. To investigate improvements in glycemic control (measured by glycated hemoglobin A1c) in patients with type 2 diabetes mellitus. Our comparative trial involved one group of patients receiving patient-centered education and another receiving didactic education. We dealt with selection bias issues, estimated the different impact of both programs, and validated our analysis using quantile regression techniques. We found evidence of better mean glycemic control in patients receiving the patient-centered program, which engaged better patients. Nevertheless, that differential impact is nonmonotonic. Patients initially at the healthy range at the patient-centered program maintained their condition better. Patients close to, but not within, the healthy range benefited equally from attending either program. Patients with very high glycemic level benefited significantly more from attending the patient-centered program. Finally, patients with the worst initial glycemic control (far from the healthy range) improved equally their diabetic condition, regardless of which program they attended. Different patients are sensitive to different categories of education programs. The optimal, cost-effective design of preventative programs for patients with chronic conditions needs to account for the different impact in different "patient categories." This implies stratifying patients and providing the appropriate preventative education program, or looking for alternative policy implementations for unresponsive patients who have the most severe condition and are the most costly. Copyright © 2016 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

The NASA Lewis Research Center's Expendable Launch Vehicle Program: An Economic Impact Study

NASA Technical Reports Server (NTRS)

Austrian, Ziona

1996-01-01

This study investigates the economic impact of the Lewis Research Center's (LeRC) Expendable Launch Vehicle Program (ELVP) on Northeast Ohio's economy. It was conducted by The Urban Center's Economic Development Program in Cleveland State University's Levin College of Urban Affairs. The study measures ELVP's direct impact on the local economy in terms of jobs, output, payroll, and taxes, as well as the indirect impact of these economic activities when they "ripple" throughout the economy. The study uses regional economic multipliers based on input-output models to estimate the effect of ELVP spending on the Northeast Ohio economy.

The NASA Lewis Research Center's Expendable Launch Vehicle Program: An Economic Impact Study

NASA Technical Reports Server (NTRS)

Austrian, Ziona

1996-01-01

This study investigates the economic impact of the Lewis Research Center's (LeRC) Expendable Launch Vehicle Program (ELVP) on Northeast Ohio's economy. It was conducted by The Urban Center's Economic Development Program in Cleveland State University's Levin College of Urban Affairs. The study measures ELVP's direct impact on the local economy in terms of jobs, output, payroll, and taxes, as well as the indirect impact of these economic activities when they 'ripple' throughout the economy. The study uses regional economic multipliers based on input-output models to estimate the effect of ELVP spending on the Northeast Ohio economy.

Future Impact of Globalism on Programs in Educational Administration.

ERIC Educational Resources Information Center

Prickett, R. L.; And Others

A descriptive analysis addressing the future impact of globalism on programs in educational administration provides perspicacity to professors in the specialty area. Emphasis on internal/global education is usually reserved for programs for individuals going to foreign countries, working with foreign countries, or providing cooperative programs…

Impact of Practice-Based Instruction on Graduate Programs in the Pharmaceutical Sciences--Another Response.

ERIC Educational Resources Information Center

Gerald, Michael C.

1979-01-01

The impact of practice-based programs on graduate education in pharmaceutical science is discussed. It is suggested that graduate programs remain flexible in order to accommodate the role of the pharmacist-scientist and to help in attracting qualified students. (SF)

The Effect of Mirthful Laughter on the Human Cardiovascular System

PubMed Central

Miller, Michael; Fry, William F.

2009-01-01

It has become increasingly recognized and more widely acknowledged during the past several decades, that a complex relationship exists between behavior associated with emotion and the human cardiovascular (CV) system. Early studies focused on the interplay between negative emotions and elevated CV risk, an effect that has in large part been attributed to increased adrenergic activity. Thus, a variety of adverse CV effects ranging from sudden cardiac death triggered by natural disasters such as earthquakes to transient myocardial stunning resulting from heightened sympathetic overload have been identified in response to acute emotional distress. In fact, the biologic interplay between emotion and CV health has been greatly enhanced through studies of the vascular endothelium. As the largest organ in humans, the inner blood vessel lining serves as a conduit for the transfer of blood cells, lipids and various nutrients across the lumen to neighboring tissues. Healthy endothelial cells secrete vasoactive chemicals, most notably endothelial-derived relaxing factor or nitric oxide (NO), that effects smooth muscle relaxation and vessel dilation via a cyclic guanosine monophosphate (cGMP) dependent protein kinase signaling pathway. In addition, endothelial derived NO may reduce vascular inflammation by attenuating or inhibiting leukocyte adhesion and subendothelial transmigration as well as decreasing platelet activation via cGMP mediated pathways. Taken together, studying the endothelium provides an exceptional opportunity to advance our understanding of the potentially important interrelationship between emotions and the vasculature. Premised on the identification of physiological and biochemical correlates, the former was demonstrated after intracoronary administration of acetylcholine yielded paradoxical endothelial vasoconstriction in response to mental stress exercises. More recently, the brachial artery reactivity test (BART) has permitted endothelial function to be assessed in a non-invasive manner. In addition to traditional CV risk factors, exposure to negative emotions including mental stress and depression have been associated with reduced endothelial vasoreactivity as measured by BART. Whether mirthful laughter has the opposite effect garnered consideration following the discovery that μ3 opiate receptors were expressed in the vascular endothelium. Because mirthful laughter induces the release of β-endorphins which in turn have high affinity for μ3 opiate receptors, we hypothesize that such positive emotions lead to the direct release of NO and associated biological consequences. Indeed, our studies have demonstrated opposing effects on endothelial vasoreactivity between those previously established (e.g., mental stress induced by negative visual and/ or auditory stimuli) and those induced after mirthful laughter, thereby providing a potential mechanistic link between positive emotions and beneficial effects on the vasculature. This article reviews the relevant physiology and comments on the potentially wider clinical implications in the integration of this process to improve vascular health. PMID:19477604

Interventions Designed To Promote Parent-Teen Communication about Sexuality.

ERIC Educational Resources Information Center

Kirby, Douglas; Miller, Brent C.

2002-01-01

Describes different approaches used to increase parent-child communication about sexuality and summarizes studies that have measured their impact. Focuses primarily on the impact of programs on parent-child communication, but also summarizes the limited research on the impact of such programs on adolescent sexual behavior, or on other determinants…

77 FR 45652 - Final Program Environmental Impact Statement/Environmental Impact Report for the San Joaquin...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-01

... Department of Water Resources have prepared a joint Final Program Environmental Impact Statement... Department of Water Resources, South Central Region Office, 3374 East Shields Avenue, Fresno, California... of Water Resources (DWR), the U.S. Fish and Wildlife Service (FWS), the National Marine Fisheries...

76 FR 43697 - BOEMRE Information Collection Activity: Coastal Impact Assistance Program (CIAP), Renewal of a...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-21

... conservation, protection, or restoration of coastal areas, including wetland. (B) Mitigation of damage to fish... ID No. BOEM-2011-0001] BOEMRE Information Collection Activity: Coastal Impact Assistance Program... (ICR) to renew approval of the paperwork requirements that address the BOEMRE's Coastal Impact...

The Impact of a Computerized Dietary Assessment on Nutrition Knowledge

ERIC Educational Resources Information Center

Hensleigh, Katherine Elizabeth; Eddy, James M.; Wang, Min Qi; Dennison, Darwin; Chaney, J. Don

2004-01-01

In recent years, many health educators have integrated computer applications into their health education program interventions. The assessment of the impact of these interventions is limited. This study assessed the impact of the Pyramid Challenge nutrition software program on nutrition knowledge levels of students enrolled in traditional personal…

Outdoor Orientation Programs: A Critical Review of Program Impacts on Retention and Graduation

ERIC Educational Resources Information Center

Bell, Brent J.; Chang, Hong

2017-01-01

Outdoor orientation programs have a growing literature demonstrating positive impacts with students transitioning to college (Bell, Gass, Nafizer, & Starbuck, 2014). One of the most valued outcomes for colleges and universities is retention of students until successful graduation. This is an outcome few outdoor orientation researchers have…