Sample records for based shm systems

  1. Adverse event detection (AED) system for continuously monitoring and evaluating structural health status

    NASA Astrophysics Data System (ADS)

    Yun, Jinsik; Ha, Dong Sam; Inman, Daniel J.; Owen, Robert B.

    2011-03-01

    Structural damage for spacecraft is mainly due to impacts such as collision of meteorites or space debris. We present a structural health monitoring (SHM) system for space applications, named Adverse Event Detection (AED), which integrates an acoustic sensor, an impedance-based SHM system, and a Lamb wave SHM system. With these three health-monitoring methods in place, we can determine the presence, location, and severity of damage. An acoustic sensor continuously monitors acoustic events, while the impedance-based and Lamb wave SHM systems are in sleep mode. If an acoustic sensor detects an impact, it activates the impedance-based SHM. The impedance-based system determines if the impact incurred damage. When damage is detected, it activates the Lamb wave SHM system to determine the severity and location of the damage. Further, since an acoustic sensor dissipates much less power than the two SHM systems and the two systems are activated only when there is an acoustic event, our system reduces overall power dissipation significantly. Our prototype system demonstrates the feasibility of the proposed concept.

  2. A variable-frequency structural health monitoring system based on omnidirectional shear horizontal wave piezoelectric transducers

    NASA Astrophysics Data System (ADS)

    Huan, Qiang; Miao, Hongchen; Li, Faxin

    2018-02-01

    Structural health monitoring (SHM) is of great importance for engineering structures as it may detect the early degradation and thus avoid life and financial loss. Guided wave based inspection is very useful in SHM due to its capability for long distance and wide range monitoring. The fundamental shear horizontal (SH0) wave based method should be most promising since SH0 is the unique non-dispersive wave mode in plate-like structures. In this work, a sparse array SHM system based on omnidirectional SH wave piezoelectric transducers (OSH-PT) was proposed and the multi data fusion method was used for defect inspection in a 2 mm thick aluminum plate. Firstly, the performances of three types OSH-PTs was comprehensively compared and the thickness-poled d15 mode OSH-PT used in this work was demonstrated obviously superior to the other two. Then, the signal processing method and imaging algorithm for this SHM system was presented. Finally, experiments were carried out to examine the performance of the proposed SHM system in defect localization and imaging. Results indicated that this SHM system can locate a through hole as small as 0.12λ (4 mm) in diameter (where λ is the wavelength corresponding to the central operation frequency) under frequencies from 90 to 150 kHz. It can also locate multiple defects accurately based on the baseline subtraction method. Obviously, this SHM system can detect larger areas with sparse sensors because of the adopted single mode, non-dispersive and low frequency SH0 wave which can propagate long distance with small attenuation. Considering its good performances, simple data processing and sparse array, this SH0 wave-based SHM system is expected to greatly promote the applications of guided wave inspection.

  3. Structural health monitoring and probability of detection estimation

    NASA Astrophysics Data System (ADS)

    Forsyth, David S.

    2016-02-01

    Structural health monitoring (SHM) methods are often based on nondestructive testing (NDT) sensors and are often proposed as replacements for NDT to lower cost and/or improve reliability. In order to take advantage of SHM for life cycle management, it is necessary to determine the Probability of Detection (POD) of the SHM system just as for traditional NDT to ensure that the required level of safety is maintained. Many different possibilities exist for SHM systems, but one of the attractive features of SHM versus NDT is the ability to take measurements very simply after the SHM system is installed. Using a simple statistical model of POD, some authors have proposed that very high rates of SHM system data sampling can result in high effective POD even in situations where an individual test has low POD. In this paper, we discuss the theoretical basis for determining the effect of repeated inspections, and examine data from SHM experiments against this framework to show how the effective POD from multiple tests can be estimated.

  4. Uncertainty analysis of practical structural health monitoring systems currently employed for tall buildings consisting of small number of sensors

    NASA Astrophysics Data System (ADS)

    Hirai, Kenta; Mita, Akira

    2016-04-01

    Because of social background, such as repeated large earthquakes and cheating in design and construction, structural health monitoring (SHM) systems are getting strong attention. The SHM systems are in a practical phase. An SHM system consisting of small number of sensors has been introduced to 6 tall buildings in Shinjuku area. Including them, there are 2 major issues in the SHM systems consisting of small number of sensors. First, optimal system number of sensors and the location are not well-defined. In the practice, system placement is determined based on rough prediction and experience. Second, there are some uncertainties in estimation results by the SHM systems. Thus, the purpose of this research is to provide useful information for increasing reliability of SHM system and to improve estimation results based on uncertainty analysis of the SHM systems. The important damage index used here is the inter-story drift angle. The uncertainty considered here are number of sensors, earthquake motion characteristics, noise in data, error between numerical model and real building, nonlinearity of parameter. Then I have analyzed influence of each factor to estimation accuracy. The analysis conducted here will help to decide sensor system design considering valance of cost and accuracy. Because of constraint on the number of sensors, estimation results by the SHM system has tendency to provide smaller values. To overcome this problem, a compensation algorithm was discussed and presented. The usefulness of this compensation method was demonstrated for 40 story S and RC building models with nonlinear response.

  5. Knowledge Discovery from Vibration Measurements

    PubMed Central

    Li, Jian; Wang, Daoyao

    2014-01-01

    The framework as well as the particular algorithms of pattern recognition process is widely adopted in structural health monitoring (SHM). However, as a part of the overall process of knowledge discovery from data bases (KDD), the results of pattern recognition are only changes and patterns of changes of data features. In this paper, based on the similarity between KDD and SHM and considering the particularity of SHM problems, a four-step framework of SHM is proposed which extends the final goal of SHM from detecting damages to extracting knowledge to facilitate decision making. The purposes and proper methods of each step of this framework are discussed. To demonstrate the proposed SHM framework, a specific SHM method which is composed by the second order structural parameter identification, statistical control chart analysis, and system reliability analysis is then presented. To examine the performance of this SHM method, real sensor data measured from a lab size steel bridge model structure are used. The developed four-step framework of SHM has the potential to clarify the process of SHM to facilitate the further development of SHM techniques. PMID:24574933

  6. Results in standardization of FOS to support the use of SHM systems

    NASA Astrophysics Data System (ADS)

    Habel, Wolfgang R.; Krebber, Katerina; Daum, Werner

    2016-05-01

    Measurement and data recording systems are important parts of a holistic Structural Health Monitoring (SHM) system. New sensor technologies such as fiber-optic sensors are often used; however, standards (or at least guidelines) are not yet available or internationally approved. This lack in standardization makes the acceptance of FOS technologies in complex SHM systems substantially difficult. A standard family for different FOS technologies is therefore being developed that should help to design SHM systems in an optimal way. International standardization activities take place in several standardization bodies such as IEC and ASTM, and within SHM societies such as ISHMII. The paper reports on activities in standardization of fiber-optic sensors, on results already achieved, and on newly started projects. Combined activities of fiber sensor experts and SHM experts from Civil Engineering are presented. These contributions should help owners of structures as well as developers of sensors and monitoring systems to select effective and validated sensing technologies. Using these standards, both parties find recommendations how to proceed in development of SHM systems to evaluate the structural behavior based on e.g. standardized fiber optic sensors, and to derive necessary measures, e.g. the optimal maintenance strategy.

  7. Fatigue of Ti6Al4V Structural Health Monitoring Systems Produced by Selective Laser Melting.

    PubMed

    Strantza, Maria; Vafadari, Reza; de Baere, Dieter; Vrancken, Bey; van Paepegem, Wim; Vandendael, Isabelle; Terryn, Herman; Guillaume, Patrick; van Hemelrijck, Danny

    2016-02-11

    Selective laser melting (SLM) is an additive manufacturing (AM) process which is used for producing metallic components. Currently, the integrity of components produced by SLM is in need of improvement due to residual stresses and unknown fracture behavior. Titanium alloys produced by AM are capable candidates for applications in aerospace and industrial fields due to their fracture resistance, fatigue behavior and corrosion resistance. On the other hand, structural health monitoring (SHM) system technologies are promising and requested from the industry. SHM systems can monitor the integrity of a structure and during the last decades the research has primarily been influenced by bionic engineering. In that aspect a new philosophy for SHM has been developed: the so-called effective structural health monitoring (eSHM) system. The current system uses the design freedom provided by AM. The working principle of the system is based on crack detection by means of a network of capillaries that are integrated in a structure. The main objective of this research is to evaluate the functionality of Ti6Al4V produced by the SLM process in the novel SHM system and to confirm that the eSHM system can successfully detect cracks in SLM components. In this study four-point bending fatigue tests on Ti6Al4V SLM specimens with an integrated SHM system were conducted. Fractographic analysis was performed after the final failure, while finite element simulations were used in order to determine the stress distribution in the capillary region and on the component. It was proven that the SHM system does not influence the crack initiation behavior during fatigue. The results highlight the effectiveness of the eSHM on SLM components, which can potentially be used by industrial and aerospace applications.

  8. Integrated Systems Health Management as an Enabler for Condition Based Maintenance and Autonomic Logistics

    DTIC Science & Technology

    2015-09-17

    turbines , SHM tools, maintenance scheduling, and performance of the SHM system determine the added value of the system of systems (A. Van Horenbeek...J. R., & Pintelon, L. (2013). Quantifying the added value of an imperfectly performing condition monitoring system— Application to a wind turbine ...INTEGRATED SYSTEMS HEALTH MANAGEMENT AS AN ENABLER FOR CONDITION BASED MAINTENANCE AND AUTONOMIC

  9. Combining model based and data based techniques in a robust bridge health monitoring algorithm.

    DOT National Transportation Integrated Search

    2014-09-01

    Structural Health Monitoring (SHM) aims to analyze civil, mechanical and aerospace systems in order to assess : incipient damage occurrence. In this project, we are concerned with the development of an algorithm within the : SHM paradigm for applicat...

  10. Active Wireless System for Structural Health Monitoring Applications.

    PubMed

    Perera, Ricardo; Pérez, Alberto; García-Diéguez, Marta; Zapico-Valle, José Luis

    2017-12-11

    The use of wireless sensors in Structural Health Monitoring (SHM) has increased significantly in the last years. Piezoelectric-based lead zirconium titanate (PZT) sensors have been on the rise in SHM due to their superior sensing abilities. They are applicable in different technologies such as electromechanical impedance (EMI)-based SHM. This work develops a flexible wireless smart sensor (WSS) framework based on the EMI method using active sensors for full-scale and autonomous SHM. In contrast to passive sensors, the self-sensing properties of the PZTs allow interrogating with or exciting a structure when desired. The system integrates the necessary software and hardware within a service-oriented architecture approach able to provide in a modular way the services suitable to satisfy the key requirements of a WSS. The framework developed in this work has been validated on different experimental applications. Initially, the reliability of the EMI method when carried out with the proposed wireless sensor system is evaluated by comparison with the wireless counterpart. Afterwards, the performance of the system is evaluated in terms of software stability and reliability of functioning.

  11. Bridge reliability assessment based on the PDF of long-term monitored extreme strains

    NASA Astrophysics Data System (ADS)

    Jiao, Meiju; Sun, Limin

    2011-04-01

    Structural health monitoring (SHM) systems can provide valuable information for the evaluation of bridge performance. As the development and implementation of SHM technology in recent years, the data mining and use has received increasingly attention and interests in civil engineering. Based on the principle of probabilistic and statistics, a reliability approach provides a rational basis for analysis of the randomness in loads and their effects on structures. A novel approach combined SHM systems with reliability method to evaluate the reliability of a cable-stayed bridge instrumented with SHM systems was presented in this paper. In this study, the reliability of the steel girder of the cable-stayed bridge was denoted by failure probability directly instead of reliability index as commonly used. Under the assumption that the probability distributions of the resistance are independent to the responses of structures, a formulation of failure probability was deduced. Then, as a main factor in the formulation, the probability density function (PDF) of the strain at sensor locations based on the monitoring data was evaluated and verified. That Donghai Bridge was taken as an example for the application of the proposed approach followed. In the case study, 4 years' monitoring data since the operation of the SHM systems was processed, and the reliability assessment results were discussed. Finally, the sensitivity and accuracy of the novel approach compared with FORM was discussed.

  12. Structural health monitoring of engineered structures using a space-borne synthetic aperture radar multi-temporal approach: from cultural heritage sites to war zones

    NASA Astrophysics Data System (ADS)

    Milillo, Pietro; Tapete, Deodato; Cigna, Francesca; Perissin, Daniele; Salzer, Jacqueline; Lundgren, Paul; Fielding, Eric; Burgmann, Roland; Biondi, Filippo; Milillo, Giovanni; Serio, Carmine

    2016-10-01

    Structural health monitoring (SHM) of engineered structures consists of an automated or semi-automated survey system that seeks to assess the structural condition of an anthropogenic structure. The aim of an SHM system is to provide insights into possible induced damage or any inherent signals of deformation affecting the structure in terms of detection, localization, assessment, and prediction. During the last decade there has been a growing interest in using several remote sensing techniques, such as synthetic aperture radar (SAR), for SHM. Constellations of SAR satellites with short repeat time acquisitions permit detailed surveys temporal resolution and millimetric sensitivity to deformation that are at the scales relevant to monitoring large structures. The all-weather multi-temporal characteristics of SAR make its products suitable for SHM systems, especially in areas where in situ measurements are not feasible or not cost effective. To illustrate this capability, we present results from COSMO-SkyMed (CSK) and TerraSAR-X SAR observations applied to the remote sensing of engineered structures. We show how by using multiple-geometry SAR-based products which exploit both phase and amplitude of the SAR signal we can address the main objectives of an SHM system including detection and localization. We highlight that, when external data such as rain or temperature records are available or simple elastic models can be assumed, the SAR-based SHM capability can also provide an interpretation in terms of assessment and prediction. We highlight examples of the potential for such imaging capabilities to enable advances in SHM from space, focusing on dams and cultural heritage areas.

  13. Evaluation of SHM system produced by additive manufacturing via acoustic emission and other NDT methods.

    PubMed

    Strantza, Maria; Aggelis, Dimitrios G; de Baere, Dieter; Guillaume, Patrick; van Hemelrijck, Danny

    2015-10-21

    During the last decades, structural health monitoring (SHM) systems are used in order to detect damage in structures. We have developed a novel structural health monitoring approach, the so-called "effective structural health monitoring" (eSHM) system. The current SHM system is incorporated into a metallic structure by means of additive manufacturing (AM) and has the possibility to advance life safety and reduce direct operative costs. It operates based on a network of capillaries that are integrated into an AM structure. The internal pressure of the capillaries is continuously monitored by a pressure sensor. When a crack nucleates and reaches the capillary, the internal pressure changes signifying the existence of the flaw. The main objective of this paper is to evaluate the crack detection capacity of the eSHM system and crack location accuracy by means of various non-destructive testing (NDT) techniques. During this study, detailed acoustic emission (AE) analysis was applied in AM materials for the first time in order to investigate if phenomena like the Kaiser effect and waveform parameters used in conventional metals can offer valuable insight into the damage accumulation of the AM structure as well. Liquid penetrant inspection, eddy current and radiography were also used in order to confirm the fatigue damage and indicate the damage location on un-notched four-point bending AM metallic specimens with an integrated eSHM system. It is shown that the eSHM system in combination with NDT can provide correct information on the damage condition of additive manufactured metals.

  14. Evaluation of SHM System Produced by Additive Manufacturing via Acoustic Emission and Other NDT Methods

    PubMed Central

    Strantza, Maria; Aggelis, Dimitrios G.; de Baere, Dieter; Guillaume, Patrick; van Hemelrijck, Danny

    2015-01-01

    During the last decades, structural health monitoring (SHM) systems are used in order to detect damage in structures. We have developed a novel structural health monitoring approach, the so-called “effective structural health monitoring” (eSHM) system. The current SHM system is incorporated into a metallic structure by means of additive manufacturing (AM) and has the possibility to advance life safety and reduce direct operative costs. It operates based on a network of capillaries that are integrated into an AM structure. The internal pressure of the capillaries is continuously monitored by a pressure sensor. When a crack nucleates and reaches the capillary, the internal pressure changes signifying the existence of the flaw. The main objective of this paper is to evaluate the crack detection capacity of the eSHM system and crack location accuracy by means of various non-destructive testing (NDT) techniques. During this study, detailed acoustic emission (AE) analysis was applied in AM materials for the first time in order to investigate if phenomena like the Kaiser effect and waveform parameters used in conventional metals can offer valuable insight into the damage accumulation of the AM structure as well. Liquid penetrant inspection, eddy current and radiography were also used in order to confirm the fatigue damage and indicate the damage location on un-notched four-point bending AM metallic specimens with an integrated eSHM system. It is shown that the eSHM system in combination with NDT can provide correct information on the damage condition of additive manufactured metals. PMID:26506349

  15. Citizen Sensors for SHM: Towards a Crowdsourcing Platform

    PubMed Central

    Ozer, Ekin; Feng, Maria Q.; Feng, Dongming

    2015-01-01

    This paper presents an innovative structural health monitoring (SHM) platform in terms of how it integrates smartphone sensors, the web, and crowdsourcing. The ubiquity of smartphones has provided an opportunity to create low-cost sensor networks for SHM. Crowdsourcing has given rise to citizen initiatives becoming a vast source of inexpensive, valuable but heterogeneous data. Previously, the authors have investigated the reliability of smartphone accelerometers for vibration-based SHM. This paper takes a step further to integrate mobile sensing and web-based computing for a prospective crowdsourcing-based SHM platform. An iOS application was developed to enable citizens to measure structural vibration and upload the data to a server with smartphones. A web-based platform was developed to collect and process the data automatically and store the processed data, such as modal properties of the structure, for long-term SHM purposes. Finally, the integrated mobile and web-based platforms were tested to collect the low-amplitude ambient vibration data of a bridge structure. Possible sources of uncertainties related to citizens were investigated, including the phone location, coupling conditions, and sampling duration. The field test results showed that the vibration data acquired by smartphones operated by citizens without expertise are useful for identifying structural modal properties with high accuracy. This platform can be further developed into an automated, smart, sustainable, cost-free system for long-term monitoring of structural integrity of spatially distributed urban infrastructure. Citizen Sensors for SHM will be a novel participatory sensing platform in the way that it offers hybrid solutions to transitional crowdsourcing parameters. PMID:26102490

  16. Deployment of a Smart Structural Health Monitoring System for Long-Span Arch Bridges: A Review and a Case Study

    PubMed Central

    Chen, Zengshun; Zhou, Xiao; Wang, Xu; Dong, Lili; Qian, Yuanhao

    2017-01-01

    Structural health monitoring (SHM) technology for surveillance and evaluation of existing and newly built long-span bridges has been widely developed, and the significance of the technique has been recognized by many administrative authorities. The paper reviews the recent progress of the SHM technology that has been applied to long-span bridges. The deployment of a SHM system is introduced. Subsequently, the data analysis and condition assessment including techniques on modal identification, methods on signal processing, and damage identification were reviewed and summarized. A case study about a SHM system of a long-span arch bridge (the Jiubao bridge in China) was systematically incorporated in each part to advance our understanding of deployment and investigation of a SHM system for long-span arch bridges. The applications of SHM systems of long-span arch bridge were also introduced. From the illustrations, the challenges and future trends for development a SHM system were concluded. PMID:28925943

  17. The performance of a piezoelectric-sensor-based SHM system under a combined cryogenic temperature and vibration environment

    NASA Astrophysics Data System (ADS)

    Qing, Xinlin P.; Beard, Shawn J.; Kumar, Amrita; Sullivan, Kevin; Aguilar, Robert; Merchant, Munir; Taniguchi, Mike

    2008-10-01

    A series of tests have been conducted to determine the survivability and functionality of a piezoelectric-sensor-based active structural health monitoring (SHM) SMART Tape system under the operating conditions of typical liquid rocket engines such as cryogenic temperature and vibration loads. The performance of different piezoelectric sensors and a low temperature adhesive under cryogenic temperature was first investigated. The active SHM system for liquid rocket engines was exposed to flight vibration and shock environments on a simulated large booster LOX-H2 engine propellant duct conditioned to cryogenic temperatures to evaluate the physical robustness of the built-in sensor network as well as operational survivability and functionality. Test results demonstrated that the developed SMART Tape system can withstand operational levels of vibration and shock energy on a representative rocket engine duct assembly, and is functional under the combined cryogenic temperature and vibration environment.

  18. X-33/RLV System Health Management/ Vehicle Health Management

    NASA Technical Reports Server (NTRS)

    Garbos, Raymond J.; Mouyos, William

    1998-01-01

    To reduce operations cost, the RLV must include the following elements: highly reliable, robust subsystems designed for simple repair access with a simplified servicing infrastructure and incorporating expedited decision making about faults and anomalies. A key component for the Single Stage to Orbit (SSTO) RLV System used to meet these objectives is System Health Management (SHM). SHM deals with the vehicle component- Vehicle Health Management (VHM), the ground processing associated with the fleet (GVHM) and the Ground Infrastructure Health Management (GIHM). The objective is to provide an automated collection and paperless health decision, maintenance and logistics system. Many critical technologies are necessary to make the SHM (and more specifically VHM) practical, reliable and cost effective. Sanders is leading the design, development and integration of the SHM system for RLV and X-33 SHM (a sub-scale, sub-orbit Advanced Technology Demonstrator). This paper will present the X-33 SHM design which forms the baseline for RLV SHM. This paper will also discuss other applications of these technologies.

  19. Inspection of Piezoceramic Transducers Used for Structural Health Monitoring

    PubMed Central

    Mueller, Inka; Fritzen, Claus-Peter

    2017-01-01

    The use of piezoelectric wafer active sensors (PWAS) for structural health monitoring (SHM) purposes is state of the art for acousto-ultrasonic-based methods. For system reliability, detailed information about the PWAS itself is necessary. This paper gives an overview on frequent PWAS faults and presents the effects of these faults on the wave propagation, used for active acousto-ultrasonics-based SHM. The analysis of the wave field is based on velocity measurements using a laser Doppler vibrometer (LDV). New and established methods of PWAS inspection are explained in detail, listing advantages and disadvantages. The electro-mechanical impedance spectrum as basis for these methods is discussed for different sensor faults. This way this contribution focuses on a detailed analysis of PWAS and the need of their inspection for an increased reliability of SHM systems. PMID:28772431

  20. Fiber Optic Sensors for Structural Health Monitoring of Air Platforms

    PubMed Central

    Guo, Honglei; Xiao, Gaozhi; Mrad, Nezih; Yao, Jianping

    2011-01-01

    Aircraft operators are faced with increasing requirements to extend the service life of air platforms beyond their designed life cycles, resulting in heavy maintenance and inspection burdens as well as economic pressure. Structural health monitoring (SHM) based on advanced sensor technology is potentially a cost-effective approach to meet operational requirements, and to reduce maintenance costs. Fiber optic sensor technology is being developed to provide existing and future aircrafts with SHM capability due to its unique superior characteristics. This review paper covers the aerospace SHM requirements and an overview of the fiber optic sensor technologies. In particular, fiber Bragg grating (FBG) sensor technology is evaluated as the most promising tool for load monitoring and damage detection, the two critical SHM aspects of air platforms. At last, recommendations on the implementation and integration of FBG sensors into an SHM system are provided. PMID:22163816

  1. Energy Harvesting for Structural Health Monitoring Sensor Networks

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Park, G.; Farrar, C. R.; Todd, M. D.

    2007-02-26

    This report has been developed based on information exchanges at a 2.5-day workshop on energy harvesting for embedded structural health monitoring (SHM) sensing systems that was held June 28-30, 2005, at Los Alamos National Laboratory. The workshop was hosted by the LANL/UCSD Engineering Institute (EI). This Institute is an education- and research-focused collaboration between Los Alamos National Laboratory (LANL) and the University of California, San Diego (UCSD), Jacobs School of Engineering. A Statistical Pattern Recognition paradigm for SHM is first presented and the concept of energy harvesting for embedded sensing systems is addressed with respect to the data acquisition portionmore » of this paradigm. Next, various existing and emerging sensing modalities used for SHM and their respective power requirements are summarized, followed by a discussion of SHM sensor network paradigms, power requirements for these networks and power optimization strategies. Various approaches to energy harvesting and energy storage are discussed and limitations associated with the current technology are addressed. This discussion also addresses current energy harvesting applications and system integration issues. The report concludes by defining some future research directions and possible technology demonstrations that are aimed at transitioning the concept of energy harvesting for embedded SHM sensing systems from laboratory research to field-deployed engineering prototypes.« less

  2. Direction-sensitive smart monitoring of structures using heterogeneous smartphone sensor data and coordinate system transformation

    NASA Astrophysics Data System (ADS)

    Ozer, Ekin; Feng, Maria Q.

    2017-04-01

    Mobile, heterogeneous, and smart sensor networks produce pervasive structural health monitoring (SHM) information. With various embedded sensors, smartphones have emerged to innovate SHM by empowering citizens to serve as sensors. By default, smartphones meet the fundamental smart sensor criteria, thanks to the built-in processor, memory, wireless communication units and mobile operating system. SHM using smartphones, however, faces technical challenges due to citizen-induced uncertainties, undesired sensor-structure integration, and lack of control over the sensing platform. Previously, the authors presented successful applications of smartphone accelerometers for structural vibration measurement and proposed a monitoring framework under citizen-induced spatiotemporal uncertainties. This study aims at extending the capabilities of smartphone-based SHM with a special focus on the lack of control over the sensor (i.e., the phone) positioning by citizens resulting in unknown sensor orientations. Using smartphone gyroscope, accelerometer, and magnetometer; instantaneous sensor orientation can be obtained with respect to gravitational and magnetic north directions. Using these sensor data, mobile operating system frameworks return processed features such as attitude and heading that can be used to correct misaligned sensor signals. For this purpose, a coordinate transformation procedure is proposed and illustrated on a two-story laboratory structural model and real-scale bridges with various sensor positioning examples. The proposed method corrects the sensor signals by tracking their orientations and improves measurement accuracy. Moreover, knowing structure’s coordinate system a priori, even the data from arbitrarily positioned sensors can automatically be transformed to the structural coordinates. In addition, this paper also touches some secondary mobile and heterogeneous data issues including imperfect sampling and geolocation services. The coordinate system transformation methods proposed in this study can be implemented in other non-smartphone-based SHM systems as long as similar instrumentation is available.

  3. Synthesizing spatiotemporally sparse smartphone sensor data for bridge modal identification

    NASA Astrophysics Data System (ADS)

    Ozer, Ekin; Feng, Maria Q.

    2016-08-01

    Smartphones as vibration measurement instruments form a large-scale, citizen-induced, and mobile wireless sensor network (WSN) for system identification and structural health monitoring (SHM) applications. Crowdsourcing-based SHM is possible with a decentralized system granting citizens with operational responsibility and control. Yet, citizen initiatives introduce device mobility, drastically changing SHM results due to uncertainties in the time and the space domains. This paper proposes a modal identification strategy that fuses spatiotemporally sparse SHM data collected by smartphone-based WSNs. Multichannel data sampled with the time and the space independence is used to compose the modal identification parameters such as frequencies and mode shapes. Structural response time history can be gathered by smartphone accelerometers and converted into Fourier spectra by the processor units. Timestamp, data length, energy to power conversion address temporal variation, whereas spatial uncertainties are reduced by geolocation services or determining node identity via QR code labels. Then, parameters collected from each distributed network component can be extended to global behavior to deduce modal parameters without the need of a centralized and synchronous data acquisition system. The proposed method is tested on a pedestrian bridge and compared with a conventional reference monitoring system. The results show that the spatiotemporally sparse mobile WSN data can be used to infer modal parameters despite non-overlapping sensor operation schedule.

  4. X-33/RLV System Health Management/Vehicle Health Management

    NASA Technical Reports Server (NTRS)

    Mouyos, William; Wangu, Srimal

    1998-01-01

    To reduce operations costs, Reusable Launch Vehicles (RLVS) must include highly reliable robust subsystems which are designed for simple repair access with a simplified servicing infrastructure, and which incorporate expedited decision-making about faults and anomalies. A key component for the Single Stage To Orbit (SSTO) RLV system used to meet these objectives is System Health Management (SHM). SHM incorporates Vehicle Health Management (VHM), ground processing associated with the vehicle fleet (GVHM), and Ground Infrastructure Health Management (GIHM). The primary objective of SHM is to provide an automated and paperless health decision, maintenance, and logistics system. Sanders, a Lockheed Martin Company, is leading the design, development, and integration of the SHM system for RLV and for X-33 (a sub-scale, sub-orbit Advanced Technology Demonstrator). Many critical technologies are necessary to make SHM (and more specifically VHM) practical, reliable, and cost effective. This paper will present the X-33 SHM design which forms the baseline for the RLV SHM, and it will discuss applications of advanced technologies to future RLVs. In addition, this paper will describe a Virtual Design Environment (VDE) which is being developed for RLV. This VDE will allow for system design engineering, as well as program management teams, to accurately and efficiently evaluate system designs, analyze the behavior of current systems, and predict the feasibility of making smooth and cost-efficient transitions from older technologies to newer ones. The RLV SHM design methodology will reduce program costs, decrease total program life-cycle time, and ultimately increase mission success.

  5. A hybrid system identification methodology for wireless structural health monitoring systems based on dynamic substructuring

    NASA Astrophysics Data System (ADS)

    Dragos, Kosmas; Smarsly, Kay

    2016-04-01

    System identification has been employed in numerous structural health monitoring (SHM) applications. Traditional system identification methods usually rely on centralized processing of structural response data to extract information on structural parameters. However, in wireless SHM systems the centralized processing of structural response data introduces a significant communication bottleneck. Exploiting the merits of decentralization and on-board processing power of wireless SHM systems, many system identification methods have been successfully implemented in wireless sensor networks. While several system identification approaches for wireless SHM systems have been proposed, little attention has been paid to obtaining information on the physical parameters (e.g. stiffness, damping) of the monitored structure. This paper presents a hybrid system identification methodology suitable for wireless sensor networks based on the principles of component mode synthesis (dynamic substructuring). A numerical model of the monitored structure is embedded into the wireless sensor nodes in a distributed manner, i.e. the entire model is segmented into sub-models, each embedded into one sensor node corresponding to the substructure the sensor node is assigned to. The parameters of each sub-model are estimated by extracting local mode shapes and by applying the equations of the Craig-Bampton method on dynamic substructuring. The proposed methodology is validated in a laboratory test conducted on a four-story frame structure to demonstrate the ability of the methodology to yield accurate estimates of stiffness parameters. Finally, the test results are discussed and an outlook on future research directions is provided.

  6. Structural Health Management for Future Aerospace Vehicles

    NASA Technical Reports Server (NTRS)

    Prosser, W. H.; Allison, S. G.; Woodard, S. E.; Wincheski, R. A.; Cooper, E. G.; Price, D. C.; Hedley, M.; Prokopenko, M.; Scott, D. A.; Tessler, A.

    2004-01-01

    Structural Health Management (SHM) will be of critical importance to provide the safety, reliability and affordability necessary for the future long duration space missions described in America's Vision for Space Exploration. Long duration missions to the Moon, Mars and beyond cannot be accomplished with the current paradigm of periodic, ground based structural integrity inspections. As evidenced by the Columbia tragedy, this approach is also inadequate for the current Shuttle fleet, thus leading to its initial implementation of on-board SHM sensing for impact detection as part of the return to flight effort. However, future space systems, to include both vehicles as well as structures such as habitation modules, will require an integrated array of onboard in-situ sensing systems. In addition, advanced data systems architectures will be necessary to communicate, store and process massive amounts of SHM data from large numbers of diverse sensors. Further, improved structural analysis and design algorithms will be necessary to incorporate SHM sensing into the design and construction of aerospace structures, as well as to fully utilize these sensing systems to provide both diagnosis and prognosis of structural integrity. Ultimately, structural integrity information will feed into an Integrated Vehicle Health Management (IVHM) system that will provide real-time knowledge of structural, propulsion, thermal protection and other critical systems for optimal vehicle management and mission control. This paper will provide an overview of NASA research and development in the area of SHM as well as to highlight areas of technology improvement necessary to meet these future mission requirements.

  7. Hardware Specific Integration Strategy for Impedance-Based Structural Health Monitoring of Aerospace Systems

    NASA Technical Reports Server (NTRS)

    Owen, Robert B.; Gyekenyesi, Andrew L.; Inman, Daniel J.; Ha, Dong S.

    2011-01-01

    The Integrated Vehicle Health Management (IVHM) Project, sponsored by NASA's Aeronautics Research Mission Directorate, is conducting research to advance the state of highly integrated and complex flight-critical health management technologies and systems. An effective IVHM system requires Structural Health Monitoring (SHM). The impedance method is one such SHM technique for detection and monitoring complex structures for damage. This position paper on the impedance method presents the current state of the art, future directions, applications and possible flight test demonstrations.

  8. Autonomous self-powered structural health monitoring system

    NASA Astrophysics Data System (ADS)

    Qing, Xinlin P.; Anton, Steven R.; Zhang, David; Kumar, Amrita; Inman, Daniel J.; Ooi, Teng K.

    2010-03-01

    Structural health monitoring technology is perceived as a revolutionary method of determining the integrity of structures involving the use of multidisciplinary fields including sensors, materials, system integration, signal processing and interpretation. The core of the technology is the development of self-sufficient systems for the continuous monitoring, inspection and damage detection of structures with minimal labor involvement. A major drawback of the existing technology for real-time structural health monitoring is the requirement for external electrical power input. For some applications, such as missiles or combat vehicles in the field, this factor can drastically limit the use of the technology. Having an on-board electrical power source that is independent of the vehicle power system can greatly enhance the SHM system and make it a completely self-contained system. In this paper, using the SMART layer technology as a basis, an Autonomous Self-powered (ASP) Structural Health Monitoring (SHM) system has been developed to solve the major challenge facing the transition of SHM systems into field applications. The architecture of the self-powered SHM system was first designed. There are four major components included in the SHM system: SMART Layer with sensor network, low power consumption diagnostic hardware, rechargeable battery with energy harvesting device, and host computer with supporting software. A prototype of the integrated self-powered active SHM system was built for performance and functionality testing. Results from the evaluation tests demonstrated that a fully charged battery system is capable of powering the SHM system for active scanning up to 10 hours.

  9. Detecting delaminations and disbondings on full-scale wing composite panel by guided waves based SHM system

    NASA Astrophysics Data System (ADS)

    Monaco, E.; Boffa, N. D.; Memmolo, V.; Ricci, F.; Maio, L.

    2016-04-01

    A full-scale lower wing panel made of composite material has been designed, manufactured and sensorised within the European Funded research project named SARISTU. The authors contributed to the whole development of the system, from design to implementation as well as to the impacts campaign phase where Barely Visible and Visible Damages (BVID and VID) are to be artificially induced on the panel by a pneumatic impact machine. This work summarise part of the experimental results related to damages production, their assessment by C-SCAN as reference NDT method as well as damage detection of delimitations by a guided waves based SHM. The SHM system is made by customized piezoelectric patches secondary bonded on the wing plate acting both as guided waves sources and receivers. The paper will deal mostly with the experimental impact campaign and the signal analyses carried out to extract the metrics more sensitive to damages induced. Image reconstruction of the damages dimensions and shapes will be also described based mostly on the combination of metrics maps over the plate partial surfaces. Finally a comparison of damages maps obtained by the SHM approach and those obtained by "classic" C-SCAN will be presented analyzing briefly pros and cons of the two different approached as a combination to the most effective structural maintenance scenario of a commercial aircraft.

  10. SHM-Based Probabilistic Fatigue Life Prediction for Bridges Based on FE Model Updating

    PubMed Central

    Lee, Young-Joo; Cho, Soojin

    2016-01-01

    Fatigue life prediction for a bridge should be based on the current condition of the bridge, and various sources of uncertainty, such as material properties, anticipated vehicle loads and environmental conditions, make the prediction very challenging. This paper presents a new approach for probabilistic fatigue life prediction for bridges using finite element (FE) model updating based on structural health monitoring (SHM) data. Recently, various types of SHM systems have been used to monitor and evaluate the long-term structural performance of bridges. For example, SHM data can be used to estimate the degradation of an in-service bridge, which makes it possible to update the initial FE model. The proposed method consists of three steps: (1) identifying the modal properties of a bridge, such as mode shapes and natural frequencies, based on the ambient vibration under passing vehicles; (2) updating the structural parameters of an initial FE model using the identified modal properties; and (3) predicting the probabilistic fatigue life using the updated FE model. The proposed method is demonstrated by application to a numerical model of a bridge, and the impact of FE model updating on the bridge fatigue life is discussed. PMID:26950125

  11. Intelligent Hardware-Enabled Sensor and Software Safety and Health Management for Autonomous UAS

    NASA Technical Reports Server (NTRS)

    Rozier, Kristin Y.; Schumann, Johann; Ippolito, Corey

    2015-01-01

    Unmanned Aerial Systems (UAS) can only be deployed if they can effectively complete their mission and respond to failures and uncertain environmental conditions while maintaining safety with respect to other aircraft as well as humans and property on the ground. We propose to design a real-time, onboard system health management (SHM) capability to continuously monitor essential system components such as sensors, software, and hardware systems for detection and diagnosis of failures and violations of safety or performance rules during the ight of a UAS. Our approach to SHM is three-pronged, providing: (1) real-time monitoring of sensor and software signals; (2) signal analysis, preprocessing, and advanced on-the- y temporal and Bayesian probabilistic fault diagnosis; (3) an unobtrusive, lightweight, read-only, low-power hardware realization using Field Programmable Gate Arrays (FPGAs) in order to avoid overburdening limited computing resources or costly re-certi cation of ight software due to instrumentation. No currently available SHM capabilities (or combinations of currently existing SHM capabilities) come anywhere close to satisfying these three criteria yet NASA will require such intelligent, hardwareenabled sensor and software safety and health management for introducing autonomous UAS into the National Airspace System (NAS). We propose a novel approach of creating modular building blocks for combining responsive runtime monitoring of temporal logic system safety requirements with model-based diagnosis and Bayesian network-based probabilistic analysis. Our proposed research program includes both developing this novel approach and demonstrating its capabilities using the NASA Swift UAS as a demonstration platform.

  12. Development of a cost-effective and flexible vibration DAQ system for long-term continuous structural health monitoring

    NASA Astrophysics Data System (ADS)

    Nguyen, Theanh; Chan, Tommy H. T.; Thambiratnam, David P.; King, Les

    2015-12-01

    In the structural health monitoring (SHM) field, long-term continuous vibration-based monitoring is becoming increasingly popular as this could keep track of the health status of structures during their service lives. However, implementing such a system is not always feasible due to on-going conflicts between budget constraints and the need of sophisticated systems to monitor real-world structures under their demanding in-service conditions. To address this problem, this paper presents a comprehensive development of a cost-effective and flexible vibration DAQ system for long-term continuous SHM of a newly constructed institutional complex with a special focus on the main building. First, selections of sensor type and sensor positions are scrutinized to overcome adversities such as low-frequency and low-level vibration measurements. In order to economically tackle the sparse measurement problem, a cost-optimized Ethernet-based peripheral DAQ model is first adopted to form the system skeleton. A combination of a high-resolution timing coordination method based on the TCP/IP command communication medium and a periodic system resynchronization strategy is then proposed to synchronize data from multiple distributed DAQ units. The results of both experimental evaluations and experimental-numerical verifications show that the proposed DAQ system in general and the data synchronization solution in particular work well and they can provide a promising cost-effective and flexible alternative for use in real-world SHM projects. Finally, the paper demonstrates simple but effective ways to make use of the developed monitoring system for long-term continuous structural health evaluation as well as to use the instrumented building herein as a multi-purpose benchmark structure for studying not only practical SHM problems but also synchronization related issues.

  13. Energy efficient wireless sensor network for structural health monitoring using distributed embedded piezoelectric transducers

    NASA Astrophysics Data System (ADS)

    Li, Peng; Olmi, Claudio; Song, Gangbing

    2010-04-01

    Piezoceramic based transducers are widely researched and used for structural health monitoring (SHM) systems due to the piezoceramic material's inherent advantage of dual sensing and actuation. Wireless sensor network (WSN) technology benefits from advances made in piezoceramic based structural health monitoring systems, allowing easy and flexible installation, low system cost, and increased robustness over wired system. However, piezoceramic wireless SHM systems still faces some drawbacks, one of these is that the piezoceramic based SHM systems require relatively high computational capabilities to calculate damage information, however, battery powered WSN sensor nodes have strict power consumption limitation and hence limited computational power. On the other hand, commonly used centralized processing networks require wireless sensors to transmit all data back to the network coordinator for analysis. This signal processing procedure can be problematic for piezoceramic based SHM applications as it is neither energy efficient nor robust. In this paper, we aim to solve these problems with a distributed wireless sensor network for piezoceramic base structural health monitoring systems. Three important issues: power system, waking up from sleep impact detection, and local data processing, are addressed to reach optimized energy efficiency. Instead of sweep sine excitation that was used in the early research, several sine frequencies were used in sequence to excite the concrete structure. The wireless sensors record the sine excitations and compute the time domain energy for each sine frequency locally to detect the energy change. By comparing the data of the damaged concrete frame with the healthy data, we are able to find out the damage information of the concrete frame. A relative powerful wireless microcontroller was used to carry out the sampling and distributed data processing in real-time. The distributed wireless network dramatically reduced the data transmission between wireless sensor and the wireless coordinator, which in turn reduced the power consumption of the overall system.

  14. Statistical analysis of modal parameters of a suspension bridge based on Bayesian spectral density approach and SHM data

    NASA Astrophysics Data System (ADS)

    Li, Zhijun; Feng, Maria Q.; Luo, Longxi; Feng, Dongming; Xu, Xiuli

    2018-01-01

    Uncertainty of modal parameters estimation appear in structural health monitoring (SHM) practice of civil engineering to quite some significant extent due to environmental influences and modeling errors. Reasonable methodologies are needed for processing the uncertainty. Bayesian inference can provide a promising and feasible identification solution for the purpose of SHM. However, there are relatively few researches on the application of Bayesian spectral method in the modal identification using SHM data sets. To extract modal parameters from large data sets collected by SHM system, the Bayesian spectral density algorithm was applied to address the uncertainty of mode extraction from output-only response of a long-span suspension bridge. The posterior most possible values of modal parameters and their uncertainties were estimated through Bayesian inference. A long-term variation and statistical analysis was performed using the sensor data sets collected from the SHM system of the suspension bridge over a one-year period. The t location-scale distribution was shown to be a better candidate function for frequencies of lower modes. On the other hand, the burr distribution provided the best fitting to the higher modes which are sensitive to the temperature. In addition, wind-induced variation of modal parameters was also investigated. It was observed that both the damping ratios and modal forces increased during the period of typhoon excitations. Meanwhile, the modal damping ratios exhibit significant correlation with the spectral intensities of the corresponding modal forces.

  15. Laser based structural health monitoring for civil, mechanical, and aerospace systems

    NASA Astrophysics Data System (ADS)

    Sohn, Hoon

    2012-04-01

    This paper provides an overview of ongoing laser ultrasonics based structural health monitoring (SHM) activities being performed by the author. Particular focus is given to (1) the development of a fully noncontact laser ultrasonic system that can easily visualize defects with high spatial resolution, (2) laser based wireless power and data transmission schemes for remote guided waves and impedance measurements, (3) minimization of false alarms due to varying operational and environmental conditions, and (4) extension to embedded laser ultrasonic excitation and sensing. SHM examples ranging from bridges to airplanes, as well as nuclear power plants, high-speed rails and wind turbines are also presented.

  16. Design of a sensor network for structural health monitoring of a full-scale composite horizontal tail

    NASA Astrophysics Data System (ADS)

    Gao, Dongyue; Wang, Yishou; Wu, Zhanjun; Rahim, Gorgin; Bai, Shengbao

    2014-05-01

    The detection capability of a given structural health monitoring (SHM) system strongly depends on its sensor network placement. In order to minimize the number of sensors while maximizing the detection capability, optimal design of the PZT sensor network placement is necessary for structural health monitoring (SHM) of a full-scale composite horizontal tail. In this study, the sensor network optimization was simplified as a problem of determining the sensor array placement between stiffeners to achieve the desired the coverage rate. First, an analysis of the structural layout and load distribution of a composite horizontal tail was performed. The constraint conditions of the optimal design were presented. Then, the SHM algorithm of the composite horizontal tail under static load was proposed. Based on the given SHM algorithm, a sensor network was designed for the full-scale composite horizontal tail structure. Effective profiles of cross-stiffener paths (CRPs) and uncross-stiffener paths (URPs) were estimated by a Lamb wave propagation experiment in a multi-stiffener composite specimen. Based on the coverage rate and the redundancy requirements, a seven-sensor array-network was chosen as the optimal sensor network for each airfoil. Finally, a preliminary SHM experiment was performed on a typical composite aircraft structure component. The reliability of the SHM result for a composite horizontal tail structure under static load was validated. In the result, the red zone represented the delamination damage. The detection capability of the optimized sensor network was verified by SHM of a full-scale composite horizontal tail; all the diagnosis results were obtained in two minutes. The result showed that all the damage in the monitoring region was covered by the sensor network.

  17. AID to overcome the limitations of genomic information by introducing somatic DNA alterations.

    PubMed

    Honjo, Tasuku; Muramatsu, Masamichi; Nagaoka, Hitoshi; Kinoshita, Kazuo; Shinkura, Reiko

    2006-05-01

    The immune system has adopted somatic DNA alterations to overcome the limitations of the genomic information. Activation induced cytidine deaminase (AID) is an essential enzyme to regulate class switch recombination (CSR), somatic hypermutation (SHM) and gene conversion (GC) of the immunoglobulin gene. AID is known to be required for DNA cleavage of S regions in CSR and V regions in SHM. However, its molecular mechanism is a focus of extensive debate. RNA editing hypothesis postulates that AID edits yet unknown mRNA, to generate specific endonucleases for CSR and SHM. By contrast, DNA deamination hypothesis assumes that AID deaminates cytosine in DNA, followed by DNA cleavage by base excision repair enzymes. We summarize the basic knowledge for molecular mechanisms for CSR and SHM and then discuss the importance of AID not only in the immune regulation but also in the genome instability.

  18. CNT-cement based composites: fabrication, self-sensing properties, and prospective applications to structural health monitoring

    NASA Astrophysics Data System (ADS)

    Rainieri, Carlo; Song, Yi; Fabbrocino, Giovanni; Schulz, Mark J.; Shanov, Vesselin

    2013-08-01

    Degradation phenomena can affect civil structures over their lifespan. The recent advances in nanotechnology and sensing allow to monitor the behaviour of a structure, assess its performance and identify damage at an early stage. Thus, maintenance actions can be carried out in a timely manner, improving structural reliability and safety. Structural Health Monitoring (SHM) is traditionally performed at a global level, with a limited number of sensors distributed over a relatively large area of a structure. Thus, only major damage conditions are detectable. Dense sensor networks and innovative structural neural systems, reproducing the structure and the function of the human nervous system, may overcome this drawback of current SHM systems. Miniaturization and embedment are key requirements for successful implementation of structural neural systems. Carbon nanotubes (CNTs) can play an attractive role in the development of embedded sensors and smart structural materials, since they can provide to traditional cement based materials both structural capability and measurable response to applied stresses, strains, cracks and other flaws. In this paper investigations about CNT/cement composites and their self-sensing capabilities are summarized and critically revised. The analysis of available experimental results and theoretical developments provides useful design criteria for the fabrication of CNT/cement composites optimized for SHM applications in civil engineering. Specific attention is paid to the opportunities provided by new RF plasma technologies for the functionalization of CNTs in view of sensor development and SHM applications.

  19. A bio-inspired structural health monitoring system based on ambient vibration

    NASA Astrophysics Data System (ADS)

    Lin, Tzu-Kang; Kiremidjian, Anne; Lei, Chi-Yang

    2010-11-01

    A structural health monitoring (SHM) system based on naïve Bayesian (NB) damage classification and DNA-like expression data was developed in this research. Adapted from the deoxyribonucleic acid (DNA) array concept in molecular biology, the proposed structural health monitoring system is constructed utilizing a double-tier regression process to extract the expression array from the structural time history recorded during external excitations. The extracted array is symbolized as the various genes of the structure from the viewpoint of molecular biology and reflects the possible damage conditions prevalent in the structure. A scaled down, six-story steel building mounted on the shaking table of the National Center for Research on Earthquake Engineering (NCREE) was used as the benchmark. The structural response at different damage levels and locations under ambient vibration was collected to support the database for the proposed SHM system. To improve the precision of detection in practical applications, the system was enhanced by an optimization process using the likelihood selection method. The obtained array representing the DNA array of the health condition of the structure was first evaluated and ranked. A total of 12 groups of expression arrays were regenerated from a combination of four damage conditions. To keep the length of the array unchanged, the best 16 coefficients from every expression array were selected to form the optimized SHM system. Test results from the ambient vibrations showed that the detection accuracy of the structural damage could be greatly enhanced by the optimized expression array, when compared to the original system. Practical verification also demonstrated that a rapid and reliable result could be given by the final system within 1 min. The proposed system implements the idea of transplanting the DNA array concept from molecular biology into the field of SHM.

  20. A structural model decomposition framework for systems health management

    NASA Astrophysics Data System (ADS)

    Roychoudhury, I.; Daigle, M.; Bregon, A.; Pulido, B.

    Systems health management (SHM) is an important set of technologies aimed at increasing system safety and reliability by detecting, isolating, and identifying faults; and predicting when the system reaches end of life (EOL), so that appropriate fault mitigation and recovery actions can be taken. Model-based SHM approaches typically make use of global, monolithic system models for online analysis, which results in a loss of scalability and efficiency for large-scale systems. Improvement in scalability and efficiency can be achieved by decomposing the system model into smaller local submodels and operating on these submodels instead. In this paper, the global system model is analyzed offline and structurally decomposed into local submodels. We define a common model decomposition framework for extracting submodels from the global model. This framework is then used to develop algorithms for solving model decomposition problems for the design of three separate SHM technologies, namely, estimation (which is useful for fault detection and identification), fault isolation, and EOL prediction. We solve these model decomposition problems using a three-tank system as a case study.

  1. A Structural Model Decomposition Framework for Systems Health Management

    NASA Technical Reports Server (NTRS)

    Roychoudhury, Indranil; Daigle, Matthew J.; Bregon, Anibal; Pulido, Belamino

    2013-01-01

    Systems health management (SHM) is an important set of technologies aimed at increasing system safety and reliability by detecting, isolating, and identifying faults; and predicting when the system reaches end of life (EOL), so that appropriate fault mitigation and recovery actions can be taken. Model-based SHM approaches typically make use of global, monolithic system models for online analysis, which results in a loss of scalability and efficiency for large-scale systems. Improvement in scalability and efficiency can be achieved by decomposing the system model into smaller local submodels and operating on these submodels instead. In this paper, the global system model is analyzed offline and structurally decomposed into local submodels. We define a common model decomposition framework for extracting submodels from the global model. This framework is then used to develop algorithms for solving model decomposition problems for the design of three separate SHM technologies, namely, estimation (which is useful for fault detection and identification), fault isolation, and EOL prediction. We solve these model decomposition problems using a three-tank system as a case study.

  2. Fiber-optically sensorized composite wing

    NASA Astrophysics Data System (ADS)

    Costa, Joannes M.; Black, Richard J.; Moslehi, Behzad; Oblea, Levy; Patel, Rona; Sotoudeh, Vahid; Abouzeida, Essam; Quinones, Vladimir; Gowayed, Yasser; Soobramaney, Paul; Flowers, George

    2014-04-01

    Electromagnetic interference (EMI) immune and light-weight, fiber-optic sensor based Structural Health Monitoring (SHM) will find increasing application in aerospace structures ranging from aircraft wings to jet engine vanes. Intelligent Fiber Optic Systems Corporation (IFOS) has been developing multi-functional fiber Bragg grating (FBG) sensor systems including parallel processing FBG interrogators combined with advanced signal processing for SHM, structural state sensing and load monitoring applications. This paper reports work with Auburn University on embedding and testing FBG sensor arrays in a quarter scale model of a T38 composite wing. The wing was designed and manufactured using fabric reinforced polymer matrix composites. FBG sensors were embedded under the top layer of the composite. Their positions were chosen based on strain maps determined by finite element analysis. Static and dynamic testing confirmed expected response from the FBGs. The demonstrated technology has the potential to be further developed into an autonomous onboard system to perform load monitoring, SHM and Non-Destructive Evaluation (NDE) of composite aerospace structures (wings and rotorcraft blades). This platform technology could also be applied to flight testing of morphing and aero-elastic control surfaces.

  3. An introduction to structural health monitoring.

    PubMed

    Farrar, Charles R; Worden, Keith

    2007-02-15

    The process of implementing a damage identification strategy for aerospace, civil and mechanical engineering infrastructure is referred to as structural health monitoring (SHM). Here, damage is defined as changes to the material and/or geometric properties of these systems, including changes to the boundary conditions and system connectivity, which adversely affect the system's performance. A wide variety of highly effective local non-destructive evaluation tools are available for such monitoring. However, the majority of SHM research conducted over the last 30 years has attempted to identify damage in structures on a more global basis. The past 10 years have seen a rapid increase in the amount of research related to SHM as quantified by the significant escalation in papers published on this subject. The increased interest in SHM and its associated potential for significant life-safety and economic benefits has motivated the need for this theme issue. This introduction begins with a brief history of SHM technology development. Recent research has begun to recognize that the SHM problem is fundamentally one of the statistical pattern recognition (SPR) and a paradigm to address such a problem is described in detail herein as it forms the basis for organization of this theme issue. In the process of providing the historical overview and summarizing the SPR paradigm, the subsequent articles in this theme issue are cited in an effort to show how they fit into this overview of SHM. In conclusion, technical challenges that must be addressed if SHM is to gain wider application are discussed in a general manner.

  4. Security challenge to using smartphones for SHM

    NASA Astrophysics Data System (ADS)

    Abueh, Yeka; Liu, Hong

    2016-04-01

    Pervasive smartphones have demonstrated great potential in structural health monitoring (SHM) of civil infrastructures. Their sensing, processing, and communication capabilities along with crowdsourcing facility ease technical difficulties and reduce financial burdens of instrumentation and monitoring for SHM in civil infrastructures. However, smartphones are vulnerable to unintentional misuses and malicious attacks. This paper analyzes the vulnerabilities of smartphones in performing SHM and reveals the exploitation of those vulnerabilities. The work probes the attack surface of both devices and data. Device attack scenarios include hacking individual smartphones to modify the data stored on them and orchestrating smartphones to launch a distributed denial-of-service attack. Specifically, experiments are conducted to remotely access an Android smartphone and modify the sensing data of structural health stored on it. The work also presents a case study that reveals the sensitivity of a popular perturbation analysis method to faulty data delivered by a smartphone. The paper provides the direction of meeting the security challenge to using smartphones for SHM. As the first line of defense, device authentication is implemented in the smartphone to stop spoofing. Subsequently, message authentication is devised to maintain data integrity. There is a need to apply data science for the SHM immunity system against the sensitivity to data inaccuracy. The work also evaluates the cost-effectiveness of the proposed security measures, recommending varying levels of security to mitigate the adversaries to smartphones used in SHM systems. It calls for security solutions at the design stage of SHM systems rather than patching up after their implementations.

  5. Field application of smart SHM using field programmable gate array technology to monitor an RC bridge in New Mexico

    NASA Astrophysics Data System (ADS)

    Azarbayejani, M.; Jalalpour, M.; El-Osery, A. I.; Reda Taha, M. M.

    2011-08-01

    In this paper, an innovative field application of a structural health monitoring (SHM) system using field programmable gate array (FPGA) technology and wireless communication is presented. The new SHM system was installed to monitor a reinforced concrete (RC) bridge on Interstate 40 (I-40) in Tucumcari, New Mexico. This newly installed system allows continuous remote monitoring of this bridge using solar power. Details of the SHM component design and installation are discussed. The integration of FPGA and solar power technologies make it possible to remotely monitor infrastructure with limited access to power. Furthermore, the use of FPGA technology enables smart monitoring where data communication takes place on-need (when damage warning signs are met) and on-demand for periodic monitoring of the bridge. Such a system enables a significant cut in communication cost and power demands which are two challenges during SHM operation. Finally, a three-dimensional finite element (FE) model of the bridge was developed and calibrated using a static loading field test. This model is then used for simulating damage occurrence on the bridge. Using the proposed automation process for SHM will reduce human intervention significantly and can save millions of dollars currently spent on prescheduled inspection of critical infrastructure worldwide.

  6. Structural health monitoring of civil infrastructure.

    PubMed

    Brownjohn, J M W

    2007-02-15

    Structural health monitoring (SHM) is a term increasingly used in the last decade to describe a range of systems implemented on full-scale civil infrastructures and whose purposes are to assist and inform operators about continued 'fitness for purpose' of structures under gradual or sudden changes to their state, to learn about either or both of the load and response mechanisms. Arguably, various forms of SHM have been employed in civil infrastructure for at least half a century, but it is only in the last decade or two that computer-based systems are being designed for the purpose of assisting owners/operators of ageing infrastructure with timely information for their continued safe and economic operation. This paper describes the motivations for and recent history of SHM applications to various forms of civil infrastructure and provides case studies on specific types of structure. It ends with a discussion of the present state-of-the-art and future developments in terms of instrumentation, data acquisition, communication systems and data mining and presentation procedures for diagnosis of infrastructural 'health'.

  7. Wireless monitoring of structural components of wind turbines including tower and foundations

    NASA Astrophysics Data System (ADS)

    Wondra, B.; Botz, M.; Grosse, C. U.

    2016-09-01

    Only few large wind turbines contain an extensive structural health monitoring (SHM) system. Such SHM systems could provide deeper insight into the real load history of a wind turbine along its standard lifetime of 20 years and support a justified extension of operation beyond the original intended period. This paper presents a new concept of a wireless SHM system based on acceleration measurement sensor nodes to permanently record acceleration of the tower structure at different heights. Exploitation of acceleration data and its referring position on the turbine tower enables calculation of vibration frequencies, their amplitudes and subsequently eigenmodes. Tower heights of 100 m and more are within the transmission range of wireless nodes, enabling a complete surveillance of the tower in three dimensions without the need for long cabling or electric signal amplification. Mounting of the sensor nodes on the tower is not limited to a few positions by the presence of an electric cable anymore. Still a comparison between data recorded by wireless sensors and data recorded by high-resolution wire-based sensors shows that the present resolution of the wireless sensors has to be improved to record accelerations more accurately and thus analyze vibration frequencies more precisely.

  8. NASA Applications of Structural Health Monitoring Technology

    NASA Technical Reports Server (NTRS)

    Richards, W Lance; Madaras, Eric I.; Prosser, William H.; Studor, George

    2013-01-01

    This presentation provides examples of research and development that has recently or is currently being conducted at NASA, with a special emphasis on the application of structural health monitoring (SHM) of aerospace vehicles. SHM applications on several vehicle programs are highlighted, including Space Shuttle Orbiter, International Space Station, Uninhabited Aerial Vehicles, and Expandable Launch Vehicles. Examples of current and previous work are presented in the following categories: acoustic emission impact detection, multi-parameter fiber optic strain-based sensing, wireless sensor system development, and distributed leak detection.

  9. NASA Applications of Structural Health Monitoring Technology

    NASA Technical Reports Server (NTRS)

    Richards, W Lance; Madaras, Eric I.; Prosser, William H.; Studor, George

    2013-01-01

    This presentation provides examples of research and development that has recently or is currently being conducted at NASA, with a special emphasis on the application of structural health monitoring (SHM) of aerospace vehicles. SHM applications on several vehicle programs are highlighted, including Space Shuttle Orbiter, the International Space Station, Uninhabited Aerial Vehicles, and Expendable Launch Vehicles. Examples of current and previous work are presented in the following categories: acoustic emission impact detection, multi-parameter fiber optic strain-based sensing, wireless sensor system development, and distributed leak detection.

  10. Frequency Selective Surface for Structural Health Monitoring

    NASA Astrophysics Data System (ADS)

    Norlyana Azemi, Saidatul; Mustaffa, Farzana Hazira Wan; Faizal Jamlos, Mohd; Abdullah Al-Hadi, Azremi; Soh, Ping Jack

    2018-03-01

    Structural health monitoring (SHM) technologies have attained attention to monitor civil structures. SHM sensor systems have been used in various civil structures such as bridges, buildings, tunnels and so on. However the previous sensor for SHM is wired and encounter with problem to cover large areas. Therefore, wireless sensor was introduced for SHM to reduce network connecting problem. Wireless sensors for Structural Health monitoring are new technology and have many advantages to overcome the drawback of conventional and wired sensor. This project proposed passive wireless SHM sensor using frequency selective surface (FSS) as an alternative to conventional sensors. The electromagnetic wave characteristic of FSS will change by geometrical changes of FSS due to mechanical strain or structural failure. The changes feature is used as a sensing function without any connecting wires. Two type of design which are circular ring and square loop along with the transmission and reflection characteristics of SHM using FSS were discussed in this project. A simulation process has shown that incident angle characteristics can be use as a data for SHM application.

  11. Fault Management Design Strategies

    NASA Technical Reports Server (NTRS)

    Day, John C.; Johnson, Stephen B.

    2014-01-01

    Development of dependable systems relies on the ability of the system to determine and respond to off-nominal system behavior. Specification and development of these fault management capabilities must be done in a structured and principled manner to improve our understanding of these systems, and to make significant gains in dependability (safety, reliability and availability). Prior work has described a fundamental taxonomy and theory of System Health Management (SHM), and of its operational subset, Fault Management (FM). This conceptual foundation provides a basis to develop framework to design and implement FM design strategies that protect mission objectives and account for system design limitations. Selection of an SHM strategy has implications for the functions required to perform the strategy, and it places constraints on the set of possible design solutions. The framework developed in this paper provides a rigorous and principled approach to classifying SHM strategies, as well as methods for determination and implementation of SHM strategies. An illustrative example is used to describe the application of the framework and the resulting benefits to system and FM design and dependability.

  12. Integration of structural health monitoring and asset management.

    DOT National Transportation Integrated Search

    2012-12-01

    The Virginia Center for Innovation and Transportation Research and Virginia Tech installed a structural health : monitoring (SHM) system on a Virginia bridge. Using data from this SHM system as input, a procedure was : developed to provide informatio...

  13. Structural health monitoring feature design by genetic programming

    NASA Astrophysics Data System (ADS)

    Harvey, Dustin Y.; Todd, Michael D.

    2014-09-01

    Structural health monitoring (SHM) systems provide real-time damage and performance information for civil, aerospace, and other high-capital or life-safety critical structures. Conventional data processing involves pre-processing and extraction of low-dimensional features from in situ time series measurements. The features are then input to a statistical pattern recognition algorithm to perform the relevant classification or regression task necessary to facilitate decisions by the SHM system. Traditional design of signal processing and feature extraction algorithms can be an expensive and time-consuming process requiring extensive system knowledge and domain expertise. Genetic programming, a heuristic program search method from evolutionary computation, was recently adapted by the authors to perform automated, data-driven design of signal processing and feature extraction algorithms for statistical pattern recognition applications. The proposed method, called Autofead, is particularly suitable to handle the challenges inherent in algorithm design for SHM problems where the manifestation of damage in structural response measurements is often unclear or unknown. Autofead mines a training database of response measurements to discover information-rich features specific to the problem at hand. This study provides experimental validation on three SHM applications including ultrasonic damage detection, bearing damage classification for rotating machinery, and vibration-based structural health monitoring. Performance comparisons with common feature choices for each problem area are provided demonstrating the versatility of Autofead to produce significant algorithm improvements on a wide range of problems.

  14. Advanced active health monitoring system of liquid rocket engines

    NASA Astrophysics Data System (ADS)

    Qing, Xinlin P.; Wu, Zhanjun; Beard, Shawn; Chang, Fu-Kuo

    2008-11-01

    An advanced SMART TAPE system has been developed for real-time in-situ monitoring and long term tracking of structural integrity of pressure vessels in liquid rocket engines. The practical implementation of the structural health monitoring (SHM) system including distributed sensor network, portable diagnostic hardware and dedicated data analysis software is addressed based on the harsh operating environment. Extensive tests were conducted on a simulated large booster LOX-H2 engine propellant duct to evaluate the survivability and functionality of the system under the operating conditions of typical liquid rocket engines such as cryogenic temperature, vibration loads. The test results demonstrated that the developed SHM system could survive the combined cryogenic temperature and vibration environments and effectively detect cracks as small as 2 mm.

  15. Integration of structural health monitoring solutions onto commercial aircraft via the Federal Aviation Administration structural health monitoring research program

    NASA Astrophysics Data System (ADS)

    Swindell, Paul; Doyle, Jon; Roach, Dennis

    2017-02-01

    The Federal Aviation Administration (FAA) started a research program in structural health monitoring (SHM) in 2011. The program's goal was to understand the technical gaps of implementing SHM on commercial aircraft and the potential effects on FAA regulations and guidance. The program evolved into a demonstration program consisting of a team from Sandia National Labs Airworthiness Assurance NDI Center (AANC), the Boeing Corporation, Delta Air Lines, Structural Monitoring Systems (SMS), Anodyne Electronics Manufacturing Corp (AEM) and the FAA. This paper will discuss the program from the selection of the inspection problem, the SHM system (Comparative Vacuum Monitoring-CVM) that was selected as the inspection solution and the testing completed to provide sufficient data to gain the first approved use of an SHM system for routine maintenance on commercial US aircraft.

  16. Transition from Nondestructive Testing (NDT) to Structural Health Monitoring (SHM): potential and challenges (presentation video)

    NASA Astrophysics Data System (ADS)

    Cawley, Peter

    2014-03-01

    There is a gradual shift in emphasis from periodic inspection with detachable transducers (NDT) to permanently installed monitoring systems giving information about the structural integrity at pre-programmed intervals or on demand (SHM). The drivers of this change are discussed, together with the requirements of successful SHM systems. Particular issues are that NDT often involves scanning and this is not possible with typical SHM configurations; it therefore becomes important to cover a significant area of structure from each transducer position. Guided waves provide a possible solution to this problem and permanently installed guided wave pipe inspection systems are now available. The sensitivity obtained with a permanently installed system is significantly better than that in a one-off test as baseline subtraction can be employed. However, this is far from trivial as it is necessary to compensate for benign changes such as temperature. The guided wave technique does not provide accurate remaining thickness information and is best complemented by point measurements at selected locations. Another issue is that the SHM transducers must survive in operational conditions, which is particularly difficult at high temperatures. Recent work at Imperial College and associated spin-out companies on solutions to these problems is discussed.

  17. Embedded Active Fiber Optic Sensing Network for Structural Health Monitoring in Harsh Environments

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Anbo

    This report summarizes technical progress on the program “Embedded Active Fiber Optic Sensing Network for Structural Health Monitoring in Harsh Environments” funded by the National Energy Technology Laboratory of the U.S. Department of Energy, and performed by the Center for Photonics Technology at Virginia Tech. The objective of this project is to develop a first-of-a-kind technology for remote fiber optic generation and detection of acoustic waves for structural health monitoring in harsh environments. During the project period, which is from April 1, 2013 to Septemeber 30, 2016, three different acoustic generation mechanisms were studied in detail for their applications inmore » building a fiber optic acoustic generation unit (AGU), including laser induced plasma breakdown (LIP), Erbium-doped fiber laser absorption, and metal laser absorption. By comparing the performance of the AGUs designed based on these three mechanisms and analyzing the experimental results with simulations, the metal laser absorption method was selected to build a complete fiber optic structure health monitoring (FO-SHM) system for the proposed high temperature multi-parameter structure health monitoring application. Based on the simulation of elastic wave propagation and fiber Bragg grating acoustic pulse detection, an FO-SHM element together with a completed interrogation system were designed and built. This system was first tested on an aluminum piece in the low-temperature range and successfully demonstrated its capability of multi-parameter monitoring and multi-point sensing. In the later stages of the project, the research was focused on improving the surface attachment design and preparing the FO-SHM element for high temperature environment tests. After several upgrades to the surface attachment methods, the FO-SHM element was able to work reliably up to 600oC when attached to P91 pipes, which are the target material of this project. In the final stage of this project, this FO-SHM sensing system was tested in the simulated harsh environment for its multi-parameter monitoring performance and high-temperature survivability.« less

  18. Virtual Environments for Visualizing Structural Health Monitoring Sensor Networks, Data, and Metadata.

    PubMed

    Napolitano, Rebecca; Blyth, Anna; Glisic, Branko

    2018-01-16

    Visualization of sensor networks, data, and metadata is becoming one of the most pivotal aspects of the structural health monitoring (SHM) process. Without the ability to communicate efficiently and effectively between disparate groups working on a project, an SHM system can be underused, misunderstood, or even abandoned. For this reason, this work seeks to evaluate visualization techniques in the field, identify flaws in current practices, and devise a new method for visualizing and accessing SHM data and metadata in 3D. More precisely, the work presented here reflects a method and digital workflow for integrating SHM sensor networks, data, and metadata into a virtual reality environment by combining spherical imaging and informational modeling. Both intuitive and interactive, this method fosters communication on a project enabling diverse practitioners of SHM to efficiently consult and use the sensor networks, data, and metadata. The method is presented through its implementation on a case study, Streicker Bridge at Princeton University campus. To illustrate the efficiency of the new method, the time and data file size were compared to other potential methods used for visualizing and accessing SHM sensor networks, data, and metadata in 3D. Additionally, feedback from civil engineering students familiar with SHM is used for validation. Recommendations on how different groups working together on an SHM project can create SHM virtual environment and convey data to proper audiences, are also included.

  19. Virtual Environments for Visualizing Structural Health Monitoring Sensor Networks, Data, and Metadata

    PubMed Central

    Napolitano, Rebecca; Blyth, Anna; Glisic, Branko

    2018-01-01

    Visualization of sensor networks, data, and metadata is becoming one of the most pivotal aspects of the structural health monitoring (SHM) process. Without the ability to communicate efficiently and effectively between disparate groups working on a project, an SHM system can be underused, misunderstood, or even abandoned. For this reason, this work seeks to evaluate visualization techniques in the field, identify flaws in current practices, and devise a new method for visualizing and accessing SHM data and metadata in 3D. More precisely, the work presented here reflects a method and digital workflow for integrating SHM sensor networks, data, and metadata into a virtual reality environment by combining spherical imaging and informational modeling. Both intuitive and interactive, this method fosters communication on a project enabling diverse practitioners of SHM to efficiently consult and use the sensor networks, data, and metadata. The method is presented through its implementation on a case study, Streicker Bridge at Princeton University campus. To illustrate the efficiency of the new method, the time and data file size were compared to other potential methods used for visualizing and accessing SHM sensor networks, data, and metadata in 3D. Additionally, feedback from civil engineering students familiar with SHM is used for validation. Recommendations on how different groups working together on an SHM project can create SHM virtual environment and convey data to proper audiences, are also included. PMID:29337877

  20. An Advanced Multi-Sensor Acousto-Ultrasonic Structural Health Monitoring System: Development and Aerospace Demonstration.

    PubMed

    Smithard, Joel; Rajic, Nik; van der Velden, Stephen; Norman, Patrick; Rosalie, Cedric; Galea, Steve; Mei, Hanfei; Lin, Bin; Giurgiutiu, Victor

    2017-07-20

    A key longstanding objective of the Structural Health Monitoring (SHM) research community is to enable the embedment of SHM systems in high value assets like aircraft to provide on-demand damage detection and evaluation. As against traditional non-destructive inspection hardware, embedded SHM systems must be compact, lightweight, low-power and sufficiently robust to survive exposure to severe in-flight operating conditions. Typical Commercial-Off-The-Shelf (COTS) systems can be bulky, costly and are often inflexible in their configuration and/or scalability, which militates against in-service deployment. Advances in electronics have resulted in ever smaller, cheaper and more reliable components that facilitate the development of compact and robust embedded SHM systems, including for Acousto-Ultrasonics (AU), a guided plate-wave inspection modality that has attracted strong interest due mainly to its capacity to furnish wide-area diagnostic coverage with a relatively low sensor density. This article provides a detailed description of the development, testing and demonstration of a new AU interrogation system called the Acousto Ultrasonic Structural health monitoring Array Module⁺ (AUSAM⁺). This system provides independent actuation and sensing on four Piezoelectric Wafer Active Sensor (PWAS) elements with further sensing on four Positive Intrinsic Negative (PIN) photodiodes for intensity-based interrogation of Fiber Bragg Gratings (FBG). The paper details the development of a novel piezoelectric excitation amplifier, which, in conjunction with flexible acquisition-system architecture, seamlessly provides electromechanical impedance spectroscopy for PWAS diagnostics over the full instrument bandwidth of 50 KHz-5 MHz. The AUSAM⁺ functionality is accessed via a simple hardware object providing a myriad of custom software interfaces that can be adapted to suit the specific requirements of each individual application.

  1. An Advanced Multi-Sensor Acousto-Ultrasonic Structural Health Monitoring System: Development and Aerospace Demonstration

    PubMed Central

    Smithard, Joel; Rajic, Nik; Norman, Patrick; Rosalie, Cedric; Galea, Steve; Mei, Hanfei; Lin, Bin; Giurgiutiu, Victor

    2017-01-01

    A key longstanding objective of the Structural Health Monitoring (SHM) research community is to enable the embedment of SHM systems in high value assets like aircraft to provide on-demand damage detection and evaluation. As against traditional non-destructive inspection hardware, embedded SHM systems must be compact, lightweight, low-power and sufficiently robust to survive exposure to severe in-flight operating conditions. Typical Commercial-Off-The-Shelf (COTS) systems can be bulky, costly and are often inflexible in their configuration and/or scalability, which militates against in-service deployment. Advances in electronics have resulted in ever smaller, cheaper and more reliable components that facilitate the development of compact and robust embedded SHM systems, including for Acousto-Ultrasonics (AU), a guided plate-wave inspection modality that has attracted strong interest due mainly to its capacity to furnish wide-area diagnostic coverage with a relatively low sensor density. This article provides a detailed description of the development, testing and demonstration of a new AU interrogation system called the Acousto Ultrasonic Structural health monitoring Array Module+ (AUSAM+). This system provides independent actuation and sensing on four Piezoelectric Wafer Active Sensor (PWAS) elements with further sensing on four Positive Intrinsic Negative (PIN) photodiodes for intensity-based interrogation of Fiber Bragg Gratings (FBG). The paper details the development of a novel piezoelectric excitation amplifier, which, in conjunction with flexible acquisition-system architecture, seamlessly provides electromechanical impedance spectroscopy for PWAS diagnostics over the full instrument bandwidth of 50 KHz–5 MHz. The AUSAM+ functionality is accessed via a simple hardware object providing a myriad of custom software interfaces that can be adapted to suit the specific requirements of each individual application. PMID:28773193

  2. Pediatric hospital medicine core competencies: development and methodology.

    PubMed

    Stucky, Erin R; Ottolini, Mary C; Maniscalco, Jennifer

    2010-01-01

    Pediatric hospital medicine is the most rapidly growing site-based pediatric specialty. There are over 2500 unique members in the three core societies in which pediatric hospitalists are members: the American Academy of Pediatrics (AAP), the Academic Pediatric Association (APA) and the Society of Hospital Medicine (SHM). Pediatric hospitalists are fulfilling both clinical and system improvement roles within varied hospital systems. Defined expectations and competencies for pediatric hospitalists are needed. In 2005, SHM's Pediatric Core Curriculum Task Force initiated the project and formed the editorial board. Over the subsequent four years, multiple pediatric hospitalists belonging to the AAP, APA, or SHM contributed to the content of and guided the development of the project. Editors and collaborators created a framework for identifying appropriate competency content areas. Content experts from both within and outside of pediatric hospital medicine participated as contributors. A number of selected national organizations and societies provided valuable feedback on chapters. The final product was validated by formal review from the AAP, APA, and SHM. The Pediatric Hospital Medicine Core Competencies were created. They include 54 chapters divided into four sections: Common Clinical Diagnoses and Conditions, Core Skills, Specialized Clinical Services, and Healthcare Systems: Supporting and Advancing Child Health. Each chapter can be used independently of the others. Chapters follow the knowledge, skills, and attitudes educational curriculum format, and have an additional section on systems organization and improvement to reflect the pediatric hospitalist's responsibility to advance systems of care. These competencies provide a foundation for the creation of pediatric hospital medicine curricula and serve to standardize and improve inpatient training practices. (c) 2010 Society of Hospital Medicine.

  3. Damage detection of structures with detrended fluctuation and detrended cross-correlation analyses

    NASA Astrophysics Data System (ADS)

    Lin, Tzu-Kang; Fajri, Haikal

    2017-03-01

    Recently, fractal analysis has shown its potential for damage detection and assessment in fields such as biomedical and mechanical engineering. For its practicability in interpreting irregular, complex, and disordered phenomena, a structural health monitoring (SHM) system based on detrended fluctuation analysis (DFA) and detrended cross-correlation analysis (DCCA) is proposed. First, damage conditions can be swiftly detected by evaluating ambient vibration signals measured from a structure through DFA. Damage locations can then be determined by analyzing the cross correlation of signals of different floors by applying DCCA. A damage index is also proposed based on multi-scale DCCA curves to improve the damage location accuracy. To verify the performance of the proposed SHM system, a four-story numerical model was used to simulate various damage conditions with different noise levels. Furthermore, an experimental verification was conducted on a seven-story benchmark structure to assess the potential damage. The results revealed that the DFA method could detect the damage conditions satisfactorily, and damage locations can be identified through the DCCA method with an accuracy of 75%. Moreover, damage locations can be correctly assessed by the damage index method with an improved accuracy of 87.5%. The proposed SHM system has promising application in practical implementations.

  4. US-Korea collaborative research for bridge monitoring test beds

    NASA Astrophysics Data System (ADS)

    Yun, C. B.; Sohn, H.; Lee, J. J.; Park, S.; Wang, M. L.; Zhang, Y. F.; Lynch, J. P.

    2010-04-01

    This paper presents an interim report on an international collaborative research project between the United States and Korea that fundamentally addresses the challenges associated with integrating structural health monitoring (SHM) system components into a comprehensive system for bridges. The objective of the project is to integrate and validate cutting-edge sensors and SHM methods under development for monitoring the long-term performance and structural integrity of highway bridges. A variety of new sensor and monitoring technologies have been selected for integration including wireless sensors, EM stress sensors and piezoelectric active sensors. Using these sensors as building blocks, the first phase of the study focuses on the design of a comprehensive SHM system that is deployed upon a series of highway bridges in Korea. With permanently installed SHM systems in place, the second phase of the study provides open access to the bridges and response data continuously collected as an internal test-bed for SHM. Currently, basic facilities including Internet lines have been constructed on the test-beds, and the participants carried out tests on bridges on the test road section owned by the Korea Expressway Corporation (KEC) with their own measurement and monitoring systems in the local area network environment. The participants were able to access and control their measurement systems by using Remote Desktop in Windows XP through Internet. Researchers interested in this test-bed are encouraged to join in the collaborative research.

  5. Goal-Function Tree Modeling for Systems Engineering and Fault Management

    NASA Technical Reports Server (NTRS)

    Johnson, Stephen B.; Breckenridge, Jonathan T.

    2013-01-01

    The draft NASA Fault Management (FM) Handbook (2012) states that Fault Management (FM) is a "part of systems engineering", and that it "demands a system-level perspective" (NASAHDBK- 1002, 7). What, exactly, is the relationship between systems engineering and FM? To NASA, systems engineering (SE) is "the art and science of developing an operable system capable of meeting requirements within often opposed constraints" (NASA/SP-2007-6105, 3). Systems engineering starts with the elucidation and development of requirements, which set the goals that the system is to achieve. To achieve these goals, the systems engineer typically defines functions, and the functions in turn are the basis for design trades to determine the best means to perform the functions. System Health Management (SHM), by contrast, defines "the capabilities of a system that preserve the system's ability to function as intended" (Johnson et al., 2011, 3). Fault Management, in turn, is the operational subset of SHM, which detects current or future failures, and takes operational measures to prevent or respond to these failures. Failure, in turn, is the "unacceptable performance of intended function." (Johnson 2011, 605) Thus the relationship of SE to FM is that SE defines the functions and the design to perform those functions to meet system goals and requirements, while FM detects the inability to perform those functions and takes action. SHM and FM are in essence "the dark side" of SE. For every function to be performed (SE), there is the possibility that it is not successfully performed (SHM); FM defines the means to operationally detect and respond to this lack of success. We can also describe this in terms of goals: for every goal to be achieved, there is the possibility that it is not achieved; FM defines the means to operationally detect and respond to this inability to achieve the goal. This brief description of relationships between SE, SHM, and FM provide hints to a modeling approach to provide formal connectivity between the nominal (SE), and off-nominal (SHM and FM) aspects of functions and designs. This paper describes a formal modeling approach to the initial phases of the development process that integrates the nominal and off-nominal perspectives in a model that unites SE goals and functions of with the failure to achieve goals and functions (SHM/FM).

  6. Develop an piezoelectric sensing based on SHM system for nuclear dry storage system

    NASA Astrophysics Data System (ADS)

    Ma, Linlin; Lin, Bin; Sun, Xiaoyi; Howden, Stephen; Yu, Lingyu

    2016-04-01

    In US, there are over 1482 dry cask storage system (DCSS) in use storing 57,807 fuel assemblies. Monitoring is necessary to determine and predict the degradation state of the systems and structures. Therefore, nondestructive monitoring is in urgent need and must be integrated into the fuel cycle to quantify the "state of health" for the safe operation of nuclear power plants (NPP) and radioactive waste storage systems (RWSS). Innovative approaches are desired to evaluate the degradation and damage of used fuel containers under extended storage. Structural health monitoring (SHM) is an emerging technology that uses in-situ sensory system to perform rapid nondestructive detection of structural damage as well as long-term integrity monitoring. It has been extensively studied in aerospace engineering over the past two decades. This paper presents the development of a SHM and damage detection methodology based on piezoelectric sensors technologies for steel canisters in nuclear dry cask storage system. Durability and survivability of piezoelectric sensors under temperature influence are first investigated in this work by evaluating sensor capacitance and electromechanical admittance. Toward damage detection, the PES are configured in pitch catch setup to transmit and receive guided waves in plate-like structures. When the inspected structure has damage such as a surface defect, the incident guided waves will be reflected or scattered resulting in changes in the wave measurements. Sparse array algorithm is developed and implemented using multiple sensors to image the structure. The sparse array algorithm is also evaluated at elevated temperature.

  7. Design and Implementation of a New System for Large Bridge Monitoring—GeoSHM

    PubMed Central

    Xie, Yilin; Ince, Sean; Ye, Jun; Bhatia, Paul

    2018-01-01

    Structural Health Monitoring (SHM) is a relatively new branch of civil engineering that focuses on assessing the health status of infrastructure, such as long-span bridges. Using a broad range of in-situ monitoring instruments, the purpose of the SHM is to help engineers understand the behaviour of structures, ensuring their structural integrity and the safety of the public. Under the Integrated Applications Promotion (IAP) scheme of the European Space Agency (ESA), a feasibility study (FS) project that used the Global Navigation Satellite Systems (GNSS) and Earth Observation (EO) for Structural Health Monitoring of Long-span Bridges (GeoSHM) was initiated in 2013. The GeoSHM FS Project was led by University of Nottingham and the Forth Road Bridge (Scotland, UK), which is a 2.5 km long suspension bridge across the Firth of Forth connecting Edinburgh and the Northern part of Scotland, was selected as the test structure for the GeoSHM FS project. Initial results have shown the significant potential of the GNSS and EO technologies. With these successes, the FS project was further extended to the demonstration stage, which is called the GeoSHM Demo project where two other long-span bridges in China were included as test structures. Led by UbiPOS UK Ltd. (Nottingham, UK), a Nottingham Hi-tech company, this stage focuses on addressing limitations identified during the feasibility study and developing an innovative data strategy to process, store, and interpret monitoring data. This paper will present an overview of the motivation and challenges of the GeoSHM Demo Project, a description of the software and hardware architecture and a discussion of some primary results that were obtained in the last three years. PMID:29510534

  8. Investigation of an expert health monitoring system for aeronautical structures based on pattern recognition and acousto-ultrasonics

    NASA Astrophysics Data System (ADS)

    Tibaduiza-Burgos, Diego Alexander; Torres-Arredondo, Miguel Angel

    2015-08-01

    Aeronautical structures are subjected to damage during their service raising the necessity for periodic inspection and maintenance of their components so that structural integrity and safe operation can be guaranteed. Cost reduction related to minimizing the out-of-service time of the aircraft, together with the advantages offered by real-time and safe-life service monitoring, have led to a boom in the design of inexpensive and structurally integrated transducer networks comprising actuators, sensors, signal processing units and controllers. These kinds of automated systems are normally referred to as smart structures and offer a multitude of new solutions to engineering problems and multi-functional capabilities. It is thus expected that structural health monitoring (SHM) systems will become one of the leading technologies for assessing and assuring the structural integrity of future aircraft. This study is devoted to the development and experimental investigation of an SHM methodology for the detection of damage in real scale complex aeronautical structures. The work focuses on each aspect of the SHM system and highlights the potentialities of the health monitoring technique based on acousto-ultrasonics and data-driven modelling within the concepts of sensor data fusion, feature extraction and pattern recognition. The methodology is experimentally demonstrated on an aircraft skin panel and fuselage panel for which several damage scenarios are analysed. The detection performance in both structures is quantified and presented.

  9. Long-Term Structural Health Monitoring System for a High-Speed Railway Bridge Structure.

    PubMed

    Ding, You-Liang; Wang, Gao-Xin; Sun, Peng; Wu, Lai-Yi; Yue, Qing

    2015-01-01

    Nanjing Dashengguan Bridge, which serves as the shared corridor crossing Yangtze River for both Beijing-Shanghai high-speed railway and Shanghai-Wuhan-Chengdu railway, is the first 6-track high-speed railway bridge with the longest span throughout the world. In order to ensure safety and detect the performance deterioration during the long-time service of the bridge, a Structural Health Monitoring (SHM) system has been implemented on this bridge by the application of modern techniques in sensing, testing, computing, and network communication. The SHM system includes various sensors as well as corresponding data acquisition and transmission equipment for automatic data collection. Furthermore, an evaluation system of structural safety has been developed for the real-time condition assessment of this bridge. The mathematical correlation models describing the overall structural behavior of the bridge can be obtained with the support of the health monitoring system, which includes cross-correlation models for accelerations, correlation models between temperature and static strains of steel truss arch, and correlation models between temperature and longitudinal displacements of piers. Some evaluation results using the mean value control chart based on mathematical correlation models are presented in this paper to show the effectiveness of this SHM system in detecting the bridge's abnormal behaviors under the varying environmental conditions such as high-speed trains and environmental temperature.

  10. Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies

    PubMed Central

    Hwang, Joyce K.; Wang, Chong; Du, Zhou; Meyers, Robin M.; Kepler, Thomas B.; Neuberg, Donna; Kwong, Peter D.; Mascola, John R.; Joyce, M. Gordon; Bonsignori, Mattia; Haynes, Barton F.; Yeap, Leng-Siew; Alt, Frederick W.

    2017-01-01

    Variable regions of Ig chains provide the antigen recognition portion of B-cell receptors and derivative antibodies. Ig heavy-chain variable region exons are assembled developmentally from V, D, J gene segments. Each variable region contains three antigen-contacting complementarity-determining regions (CDRs), with CDR1 and CDR2 encoded by the V segment and CDR3 encoded by the V(D)J junction region. Antigen-stimulated germinal center (GC) B cells undergo somatic hypermutation (SHM) of V(D)J exons followed by selection for SHMs that increase antigen-binding affinity. Some HIV-1–infected human subjects develop broadly neutralizing antibodies (bnAbs), such as the potent VRC01-class bnAbs, that neutralize diverse HIV-1 strains. Mature VRC01-class bnAbs, including VRC-PG04, accumulate very high SHM levels, a property that hinders development of vaccine strategies to elicit them. Because many VRC01-class bnAb SHMs are not required for broad neutralization, high overall SHM may be required to achieve certain functional SHMs. To elucidate such requirements, we used a V(D)J passenger allele system to assay, in mouse GC B cells, sequence-intrinsic SHM-targeting rates of nucleotides across substrates representing maturation stages of human VRC-PG04. We identify rate-limiting SHM positions for VRC-PG04 maturation, as well as SHM hotspots and intrinsically frequent deletions associated with SHM. We find that mature VRC-PG04 has low SHM capability due to hotspot saturation but also demonstrate that generation of new SHM hotspots and saturation of existing hotspot regions (e.g., CDR3) does not majorly influence intrinsic SHM in unmutated portions of VRC-PG04 progenitor sequences. We discuss implications of our findings for bnAb affinity maturation mechanisms. PMID:28747530

  11. A framework for quantifying and optimizing the value of seismic monitoring of infrastructure

    NASA Astrophysics Data System (ADS)

    Omenzetter, Piotr

    2017-04-01

    This paper outlines a framework for quantifying and optimizing the value of information from structural health monitoring (SHM) technology deployed on large infrastructure, which may sustain damage in a series of earthquakes (the main and the aftershocks). The evolution of the damage state of the infrastructure without or with SHM is presented as a time-dependent, stochastic, discrete-state, observable and controllable nonlinear dynamical system. The pre-posterior Bayesian analysis and the decision tree are used for quantifying and optimizing the value of SHM information. An optimality problem is then formulated how to decide on the adoption of SHM and how to manage optimally the usage and operations of the possibly damaged infrastructure and its repair schedule using the information from SHM. The objective function to minimize is the expected total cost or risk.

  12. Health state evaluation of shield tunnel SHM using fuzzy cluster method

    NASA Astrophysics Data System (ADS)

    Zhou, Fa; Zhang, Wei; Sun, Ke; Shi, Bin

    2015-04-01

    Shield tunnel SHM is in the path of rapid development currently while massive monitoring data processing and quantitative health grading remain a real challenge, since multiple sensors belonging to different types are employed in SHM system. This paper addressed the fuzzy cluster method based on fuzzy equivalence relationship for the health evaluation of shield tunnel SHM. The method was optimized by exporting the FSV map to automatically generate the threshold value. A new holistic health score(HHS) was proposed and its effectiveness was validated by conducting a pilot test. A case study on Nanjing Yangtze River Tunnel was presented to apply this method. Three types of indicators, namely soil pressure, pore pressure and steel strain, were used to develop the evaluation set U. The clustering results were verified by analyzing the engineering geological conditions; the applicability and validity of the proposed method was also demonstrated. Besides, the advantage of multi-factor evaluation over single-factor model was discussed by using the proposed HHS. This investigation indicated the fuzzy cluster method and HHS is capable of characterizing the fuzziness of tunnel health, and it is beneficial to clarify the tunnel health evaluation uncertainties.

  13. Packaging of structural health monitoring components

    NASA Astrophysics Data System (ADS)

    Kessler, Seth S.; Spearing, S. Mark; Shi, Yong; Dunn, Christopher T.

    2004-07-01

    Structural Health Monitoring (SHM) technologies have the potential to realize economic benefits in a broad range of commercial and defense markets. Previous research conducted by Metis Design and MIT has demonstrated the ability of Lamb waves methods to provide reliable information regarding the presence, location and type of damage in composite specimens. The present NSF funded program was aimed to study manufacturing, packaging and interface concepts for critical SHM components. The intention is to be able to cheaply manufacture robust actuating/sensing devices, and isolate them from harsh operating environments including natural, mechanical, or electrical extremes. Currently the issues related to SHM system durability have remained undressed. During the course of this research several sets of test devices were fabricated and packaged to protect the piezoelectric component assemblies for robust operation. These assemblies were then tested in hot and wet conditions, as well as in electrically noisy environments. Future work will aim to package the other supporting components such as the battery and wireless chip, as well as integrating all of these components together for operation. SHM technology will enable the reduction or complete elimination of scheduled inspections, and will allow condition-based maintenance for increased reliability and reduced overall life-cycle costs.

  14. Goal-Function Tree Modeling for Systems Engineering and Fault Management

    NASA Technical Reports Server (NTRS)

    Patterson, Jonathan D.; Johnson, Stephen B.

    2013-01-01

    The draft NASA Fault Management (FM) Handbook (2012) states that Fault Management (FM) is a "part of systems engineering", and that it "demands a system-level perspective" (NASAHDBK- 1002, 7). What, exactly, is the relationship between systems engineering and FM? To NASA, systems engineering (SE) is "the art and science of developing an operable system capable of meeting requirements within often opposed constraints" (NASA/SP-2007-6105, 3). Systems engineering starts with the elucidation and development of requirements, which set the goals that the system is to achieve. To achieve these goals, the systems engineer typically defines functions, and the functions in turn are the basis for design trades to determine the best means to perform the functions. System Health Management (SHM), by contrast, defines "the capabilities of a system that preserve the system's ability to function as intended" (Johnson et al., 2011, 3). Fault Management, in turn, is the operational subset of SHM, which detects current or future failures, and takes operational measures to prevent or respond to these failures. Failure, in turn, is the "unacceptable performance of intended function." (Johnson 2011, 605) Thus the relationship of SE to FM is that SE defines the functions and the design to perform those functions to meet system goals and requirements, while FM detects the inability to perform those functions and takes action. SHM and FM are in essence "the dark side" of SE. For every function to be performed (SE), there is the possibility that it is not successfully performed (SHM); FM defines the means to operationally detect and respond to this lack of success. We can also describe this in terms of goals: for every goal to be achieved, there is the possibility that it is not achieved; FM defines the means to operationally detect and respond to this inability to achieve the goal. This brief description of relationships between SE, SHM, and FM provide hints to a modeling approach to provide formal connectivity between the nominal (SE), and off-nominal (SHM and FM) aspects of functions and designs. This paper describes a formal modeling approach to the initial phases of the development process that integrates the nominal and off-nominal perspectives in a model that unites SE goals and functions of with the failure to achieve goals and functions (SHM/FM). This methodology and corresponding model, known as a Goal-Function Tree (GFT), provides a means to represent, decompose, and elaborate system goals and functions in a rigorous manner that connects directly to design through use of state variables that translate natural language requirements and goals into logical-physical state language. The state variable-based approach also provides the means to directly connect FM to the design, by specifying the range in which state variables must be controlled to achieve goals, and conversely, the failures that exist if system behavior go out-of-range. This in turn allows for the systems engineers and SHM/FM engineers to determine which state variables to monitor, and what action(s) to take should the system fail to achieve that goal. In sum, the GFT representation provides a unified approach to early-phase SE and FM development. This representation and methodology has been successfully developed and implemented using Systems Modeling Language (SysML) on the NASA Space Launch System (SLS) Program. It enabled early design trade studies of failure detection coverage to ensure complete detection coverage of all crew-threatening failures. The representation maps directly both to FM algorithm designs, and to failure scenario definitions needed for design analysis and testing. The GFT representation provided the basis for mapping of abort triggers into scenarios, both needed for initial, and successful quantitative analyses of abort effectiveness (detection and response to crew-threatening events).

  15. Integration of bridge damage detection concepts and components, volume I : strain-based damage detection.

    DOT National Transportation Integrated Search

    2013-10-01

    In this work, a previously-developed structural health monitoring (SHM) system was advanced toward a ready-for-implementation system. Improvements were made with respect to automated data reduction/analysis, data acquisition hardware, sensor types, a...

  16. Integration of bridge damage detection concepts and components, volume II : acceleration-based damage detection.

    DOT National Transportation Integrated Search

    2013-10-01

    In this work, a previously developed structural health monitoring (SHM) system was advanced toward a ready-for-implementation system. Improvements were made with respect to automated data reduction/analysis, data acquisition hardware, sensor types, a...

  17. Monitoring osseointegration and developing intelligent systems (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Salvino, Liming W.

    2017-05-01

    Effective monitoring of structural and biological systems is an extremely important research area that enables technology development for future intelligent devices, platforms, and systems. This presentation provides an overview of research efforts funded by the Office of Naval Research (ONR) to establish structural health monitoring (SHM) methodologies in the human domain. Basic science efforts are needed to utilize SHM sensing, data analysis, modeling, and algorithms to obtain the relevant physiological and biological information for human-specific health and performance conditions. This overview of current research efforts is based on the Monitoring Osseointegrated Prosthesis (MOIP) program. MOIP develops implantable and intelligent prosthetics that are directly anchored to the bone of residual limbs. Through real-time monitoring, sensing, and responding to osseointegration of bones and implants as well as interface conditions and environment, our research program aims to obtain individualized actionable information for implant failure identification, load estimation, infection mitigation and treatment, as well as healing assessment. Looking ahead to achieve ultimate goals of SHM, we seek to expand our research areas to cover monitoring human, biological and engineered systems, as well as human-machine interfaces. Examples of such include 1) brainwave monitoring and neurological control, 2) detecting and evaluating brain injuries, 3) monitoring and maximizing human-technological object teaming, and 4) closed-loop setups in which actions can be triggered automatically based on sensors, actuators, and data signatures. Finally, some ongoing and future collaborations across different disciplines for the development of knowledge automation and intelligent systems will be discussed.

  18. Integrated material state awareness system with self-learning symbiotic diagnostic algorithms and models

    NASA Astrophysics Data System (ADS)

    Banerjee, Sourav; Liu, Lie; Liu, S. T.; Yuan, Fuh-Gwo; Beard, Shawn

    2011-04-01

    Materials State Awareness (MSA) goes beyond traditional NDE and SHM in its challenge to characterize the current state of material damage before the onset of macro-damage such as cracks. A highly reliable, minimally invasive system for MSA of Aerospace Structures, Naval structures as well as next generation space systems is critically needed. Development of such a system will require a reliable SHM system that can detect the onset of damage well before the flaw grows to a critical size. Therefore, it is important to develop an integrated SHM system that not only detects macroscale damages in the structures but also provides an early indication of flaw precursors and microdamages. The early warning for flaw precursors and their evolution provided by an SHM system can then be used to define remedial strategies before the structural damage leads to failure, and significantly improve the safety and reliability of the structures. Thus, in this article a preliminary concept of developing the Hybrid Distributed Sensor Network Integrated with Self-learning Symbiotic Diagnostic Algorithms and Models to accurately and reliably detect the precursors to damages that occur to the structure are discussed. Experiments conducted in a laboratory environment shows potential of the proposed technique.

  19. The Single Habitat Module Concept for Exploration - Mission Planning and Mass Estimates

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe; Studak, J. W.

    2013-01-01

    The Single Habitat Module (SHM) concept approach to the infrastructure and conduct of exploration missions combines many of new promising technologies with a central concept of mission architectures that use a single habitat module for all phases of an exploration mission. Integrating mission elements near Earth and fully fueling them prior to departure of the vicinity of Earth provides the capability of using the single habitat both in transit to/from an exploration destination and while exploring the destination. The concept employs the capability to return the habitat and interplanetary propulsion system to Earth vicinity so that those elements can be reused on subsequent exploration missions. This paper provides an overview of the SHM concept and the advantages it provides. A summary of calculations of the mass of the habitat propulsion system (HPS) needed to get the habitat from Low Mars Orbit (LMO) to the surface and back to LMO and an overview of trajectory and mission mass assessments related to use of a high specific impulse space based propulsion system is provided. Those calculations lead to the conclusion that the SHM concept can significantly reduce the mass required and streamline mission operations to explore Mars (and thus all exploration destinations).

  20. The Single Habitat Module Concept for Exploration - Mission Planning and Mass Estimates

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe; Studak, J. W.

    2013-01-01

    The Single Habitat Module (SHM) concept approach to the infrastructure and conduct of exploration missions combines many new promising technologies with a central concept of mission architectures that use a single habitat module for all phases of an exploration mission. Integrating mission elements near Earth and fully fueling them prior to departure of the vicinity of Earth provides the capability of using the single habitat both in transit to/from an exploration destination and while exploring the destination. The concept employs the capability to return the habitat and interplanetary propulsion system to Earth vicinity so that those elements can be reused on subsequent exploration missions. This paper provides an overview of the SHM concept and the advantages it provides. The paper also provides a summary of calculations of the mass of the Habitat Propulsion System (HPS) needed to get the habitat from low-Mars orbit (LMO) to the surface and back to LMO, and an overview of trajectory and mission mass assessments related to use of a high specific impulse space-based propulsion system. Those calculations led to the conclusion that the SHM concept results in low total mass required and streamlines mission operations to explore Mars (or other exploration destinations).

  1. A Brillouin smart FRP material and a strain data post processing software for structural health monitoring through laboratory testing and field application on a highway bridge

    NASA Astrophysics Data System (ADS)

    Bastianini, Filippo; Matta, Fabio; Galati, Nestore; Nanni, Antonio

    2005-05-01

    Strain and temperature sensing obtained through frequency shift evaluation of Brillouin scattered light is a technology that seems extremely promising for Structural Health Monitoring (SHM). Due to the intrinsic distributed sensing capability, Brillouin can measure the deformation of any individual segment of huge lengths of inexpensive single-mode fiber. In addition, Brillouin retains other typical advantages of Fiber Optic Sensors (FOS), such as harsh environment durability and interference rejection. Despite these advantages, the diffusion of Brillouin for SHM is constrained by different factors, such as the high equipment cost, the commercial unavailability of specific SHM oriented fiber products and even some prejudices on the required sensitivity performances. In the present work, a complete SHM pilot application was developed, installed and successfully operated during a diagnostic load test on the High Performance Steel (HPS) bridge A6358 located at the Lake of the Ozarks (Miller County, MO, USA). Four out of five girders were extensively instrumented with a "smart" Glass Fiber Reinforced Polymer (GFRP) tape having embedded fibers for strain sensing and thermal compensation. Data collected during a diagnostic load test were elaborated through a specific post-processing software, and the strain profiles retrieved were compared to traditional strain gauges and theoretical results based on the AASHTO LRFD Bridge Design Specifications for structural assessment purposes. The excellent results obtained confirm the effectiveness of Brillouin SHM systems for the monitoring of real applications.

  2. Smart Composite Overwrapped Pressure Vessel - Integrated Structural Health Monitoring System to Meet Space Exploration and International Space Station Mission Assurance Needs

    NASA Technical Reports Server (NTRS)

    Saulsberry, Regor; Nichols, Charles; Waller, Jess

    2012-01-01

    Currently there are no integrated NDE methods for baselining and monitoring defect levels in fleet for Composite Overwrapped Pressure Vessels (COPVs) or related fracture critical composites, or for performing life-cycle maintenance inspections either in a traditional remove-and-inspect mode or in a more modern in situ inspection structural health monitoring (SHM) mode. Implicit in SHM and autonomous inspection is the existence of quantitative accept-reject criteria. To be effective, these criteria must correlate with levels of damage known to cause composite failure. Furthermore, implicit in SHM is the existence of effective remote sensing hardware and automated techniques and algorithms for interpretation of SHM data. SHM of facture critical composite structures, especially high pressure COPVs, is critical to the success of nearly every future NASA space exploration program as well as life extension of the International Space Station. It has been clearly stated that future NASA missions may not be successful without SHM [1]. Otherwise, crews will be busy addressing subsystem health issues and not focusing on the real NASA mission

  3. Genetic fuzzy system for online structural health monitoring of composite helicopter rotor blades

    NASA Astrophysics Data System (ADS)

    Pawar, Prashant M.; Ganguli, Ranjan

    2007-07-01

    A structural health monitoring (SHM) methodology is developed for composite rotor blades. An aeroelastic analysis of composite rotor blades based on the finite element method in space and time and with implanted matrix cracking and debonding/delamination damage is used to obtain measurable system parameters such as blade response, loads and strains. A rotor blade with a two-cell airfoil section and [0/±45/90]s family of laminates is used for numerical simulations. The model based measurements are contaminated with noise to simulate real data. Genetic fuzzy systems (GFS) are developed for global online damage detection using displacement and force-based measurement deviations between damaged and undamaged conditions and for local online damage detection using strains. It is observed that the success rate of the GFS depends on number of measurements, type of measurements and training and testing noise level. The GFS work quite well with noisy data and is recommended for online SHM of composite helicopter rotor blades.

  4. FE-ANN based modeling of 3D simple reinforced concrete girders for objective structural health evaluation.

    DOT National Transportation Integrated Search

    2017-06-01

    The structural deterioration of aging infrastructure systems and the costs of repairing these systems is an increasingly important issue worldwide. Structural health monitoring (SHM), most commonly visual inspection and condition rating, has proven t...

  5. A distributed cloud-based cyberinfrastructure framework for integrated bridge monitoring

    NASA Astrophysics Data System (ADS)

    Jeong, Seongwoon; Hou, Rui; Lynch, Jerome P.; Sohn, Hoon; Law, Kincho H.

    2017-04-01

    This paper describes a cloud-based cyberinfrastructure framework for the management of the diverse data involved in bridge monitoring. Bridge monitoring involves various hardware systems, software tools and laborious activities that include, for examples, a structural health monitoring (SHM), sensor network, engineering analysis programs and visual inspection. Very often, these monitoring systems, tools and activities are not coordinated, and the collected information are not shared. A well-designed integrated data management framework can support the effective use of the data and, thereby, enhance bridge management and maintenance operations. The cloud-based cyberinfrastructure framework presented herein is designed to manage not only sensor measurement data acquired from the SHM system, but also other relevant information, such as bridge engineering model and traffic videos, in an integrated manner. For the scalability and flexibility, cloud computing services and distributed database systems are employed. The information stored can be accessed through standard web interfaces. For demonstration, the cyberinfrastructure system is implemented for the monitoring of the bridges located along the I-275 Corridor in the state of Michigan.

  6. Effects of temperature on bridge dynamic properties : final report.

    DOT National Transportation Integrated Search

    2015-12-01

    Structural health monitoring (SHM) using ambient vibration has become a valuable tool in : evaluating and assessing the condition of civil structures. For bridge structures, a vibrationbased : SHM system uses the dynamic response of a bridge to measu...

  7. A broadband vibro-impacting power harvester with symmetrical piezoelectric bimorph-stops

    NASA Astrophysics Data System (ADS)

    Moss, S.; Barry, A.; Powlesland, I.; Galea, S.; Carman, G. P.

    2011-04-01

    The certification of retrofitted structural health monitoring (SHM) systems for use on aircraft raises a number of challenges. One critical issue is determining the optimal means of supplying power to these systems, given that access to the existing aircraft power system is often problematic. Previously, the Australian Defence Science and Technology Organisation has shown that a structural strain-based energy harvesting approach can be used to power a device for SHM of aircraft structure. Acceleration-based power harvesting from airframes can be more demanding than a strain-based approach because the vibration spectrum of an aircraft structure can vary dynamically with flight conditions. A vibration spectrum with varying frequency may severely limit the energy harvested by a single-degree-of-freedom resonance-based device, and hence a frequency agile or (relatively) broadband device is often required to maximize the energy harvested. This paper reports on an investigation into the use of a vibro-impact approach to construct a piezoelectric-based kinetic power harvester that can operate in the approximate frequency range of 29-63 Hz.

  8. Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination.

    PubMed

    Yousif, Ashraf S; Stanlie, Andre; Begum, Nasim A; Honjo, Tasuku

    2014-10-01

    Activation-induced cytidine deaminase (AID) is essential to class switch recombination (CSR) and somatic hypermutation (SHM). Uracil DNA glycosylase (UNG), a member of the base excision repair complex, is required for CSR. The role of UNG in CSR and SHM is extremely controversial. AID deficiency in mice abolishes both CSR and SHM, while UNG-deficient mice have drastically reduced CSR but augmented SHM raising a possibility of differential functions of UNG in CSR and SHM. Interestingly, UNG has been associated with a CSR-specific repair adapter protein Brd4, which interacts with acetyl histone 4, γH2AX and 53BP1 to promote non-homologous end joining during CSR. A non-canonical scaffold function of UNG, but not the catalytic activity, can be attributed to the recruitment of essential repair proteins associated with the error-free repair during SHM, and the end joining during CSR. © The Japanese Society for Immunology. 2014. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  9. Multi-tiered sensing and data processing for monitoring ship structures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Farrar, Charles; Salvino, Liming; Lynch, Jerome

    2009-01-01

    A comprehensive structural health monitoring (SHM) system is a critical mechanism to ensure hull integrity and evaluate structural performance over the life of a ship, especially for lightweight high-speed ships. One of the most important functions of a SHM system is to provide real-time performance guidance and reduce the risk of structural damage during operations at sea. This is done by continuous feedback from onboard sensors providing measurements of seaway loads and structural responses. Applications of SHM should also include diagnostic capabilities such as identifying the presence of damage, assessing the location and extent of damage when it does occurmore » in order to plan for future inspection and maintenance. The development of such SHM systems is extremely challenging because of the physical size of these structures, the widely varying and often extreme operational and environmental conditions associated with the missions of high performance ships, the lack of data from known damage conditions, the limited sensing that was not designed specifically for SHM, the management of the vast amounts of data, and the need for continued, real-time data processing. This paper will discuss some of these challenges and several outstanding issues that need to be addressed in the context of applying various SHM approaches to sea trials data measured on an aluminum high-speed catamaran, the HSV-2 Swift. A multi-tiered approach for sensing and data processing will be discussed as potential SHM architecture for future shipboard application. This approach will involve application of low cost and dense sensor arrays such as wireless communications in selected areas of the ship hull in addition to conventional sensors measuring global structural response of the ship. A recent wireless hull monitoring demo on FSF-I SeaFighter will be discussed as an example to show how this proposed architecture is a viable approach for long-term and real-time hull monitoring.« less

  10. Exploration of video-based structural health monitoring techniques.

    DOT National Transportation Integrated Search

    2014-10-01

    Structural health monitoring (SHM) has become a viable tool to provide owners with objective data for maintenance and repair. Traditionally, discrete contact sensors such as strain gages or accelerometers have been used : for SHM. However, distribute...

  11. Implementation of a novel efficient low cost method in structural health monitoring

    NASA Astrophysics Data System (ADS)

    Asadi, S.; Sepehry, N.; Shamshirsaz, M.; Vaghasloo, Y. A.

    2017-05-01

    In active structural health monitoring (SHM) methods, it is necessary to excite the structure with a preselected signal. More studies in the field of active SHM are focused on applying SHM on higher frequency ranges since it is possible to detect smaller damages, using higher excitation frequency. Also, to increase spatial domain of measurements and enhance signal to noise ratio (SNR), the amplitude of excitation signal is usually amplified. These issues become substantial where piezoelectric transducers with relatively high capacitance are used and consequently, need to utilize high power amplifiers becomes predominant. In this paper, a novel method named Step Excitation Method (SEM) is proposed and implemented for Lamb wave and transfer impedance-based SHM for damage detection in structures. Three different types of structure are studied: beam, plate and pipe. The related hardware is designed and fabricated which eliminates high power analog amplifiers and decreases complexity of driver significantly. Spectral Finite Element Method (SFEM) is applied to examine performance of proposed SEM. In proposed method, by determination of impulse response of the system, any input could be applied to the system by both finite element simulations and experiments without need for multiple measurements. The experimental results using SEM are compared with those obtained by conventional direct excitation method for healthy and damaged structures. The results show an improvement of amplitude resolution in damage detection comparing to conventional method which is due to achieving an SNR improvement up to 50%.

  12. Long-Term Structural Health Monitoring System for a High-Speed Railway Bridge Structure

    PubMed Central

    Wu, Lai-Yi

    2015-01-01

    Nanjing Dashengguan Bridge, which serves as the shared corridor crossing Yangtze River for both Beijing-Shanghai high-speed railway and Shanghai-Wuhan-Chengdu railway, is the first 6-track high-speed railway bridge with the longest span throughout the world. In order to ensure safety and detect the performance deterioration during the long-time service of the bridge, a Structural Health Monitoring (SHM) system has been implemented on this bridge by the application of modern techniques in sensing, testing, computing, and network communication. The SHM system includes various sensors as well as corresponding data acquisition and transmission equipment for automatic data collection. Furthermore, an evaluation system of structural safety has been developed for the real-time condition assessment of this bridge. The mathematical correlation models describing the overall structural behavior of the bridge can be obtained with the support of the health monitoring system, which includes cross-correlation models for accelerations, correlation models between temperature and static strains of steel truss arch, and correlation models between temperature and longitudinal displacements of piers. Some evaluation results using the mean value control chart based on mathematical correlation models are presented in this paper to show the effectiveness of this SHM system in detecting the bridge's abnormal behaviors under the varying environmental conditions such as high-speed trains and environmental temperature. PMID:26451387

  13. Protocol and Demonstrations of Probabilistic Reliability Assessment for Structural Health Monitoring Systems (Preprint)

    DTIC Science & Technology

    2011-11-01

    assessment to quality of localization/characterization estimates. This protocol includes four critical components: (1) a procedure to identify the...critical factors impacting SHM system performance; (2) a multistage or hierarchical approach to SHM system validation; (3) a model -assisted evaluation...Lindgren, E. A ., Buynak, C. F., Steffes, G., Derriso, M., “ Model -assisted Probabilistic Reliability Assessment for Structural Health Monitoring

  14. Regionalization Study of Satellite based Hydrological Model (SHM) in Hydrologically Homogeneous River Basins of India

    NASA Astrophysics Data System (ADS)

    Kumari, Babita; Paul, Pranesh Kumar; Singh, Rajendra; Mishra, Ashok; Gupta, Praveen Kumar; Singh, Raghvendra P.

    2017-04-01

    A new semi-distributed conceptual hydrological model, namely Satellite based Hydrological Model (SHM), has been developed under 'PRACRITI-2' program of Space Application Centre (SAC), Ahmedabad for sustainable water resources management of India by using data from Indian Remote Sensing satellites. Entire India is divided into 5km x 5km grid cells and properties at the center of the cells are assumed to represent the property of the cells. SHM contains five modules namely surface water, forest, snow, groundwater and routing. Two empirical equations (SCS-CN and Hargreaves) and water balance method have been used in the surface water module; the forest module is based on the calculations of water balancing & dynamics of subsurface. 2-D Boussinesq equation is used for groundwater modelling which is solved using implicit finite-difference. The routing module follows a distributed routing approach which requires flow path and network with the key point of travel time estimation. The aim of this study is to evaluate the performance of SHM using regionalization technique which also checks the usefulness of a model in data scarce condition or for ungauged basins. However, homogeneity analysis is pre-requisite to regionalization. Similarity index (Φ) and hierarchical agglomerative cluster analysis are adopted to test the homogeneity in terms of physical attributes of three basins namely Brahmani (39,033 km km^2)), Baitarani (10,982 km km^2)) and Kangsabati (9,660 km km^2)) with respect to Subarnarekha (29,196 km km^2)) basin. The results of both homogeneity analysis show that Brahmani basin is the most homogeneous with respect to Subarnarekha river basin in terms of physical characteristics (land use land cover classes, soiltype and elevation). The calibration and validation of model parameters of Brahmani basin is in progress which are to be transferred into the SHM set up of Subarnarekha basin and results are to be compared with the results of calibrated and validated parameter set up of SHM of Subarnarekha basin to test the applicability of SHM in hydrologically homogeneous regions of India. Keywords: SHM, regionalization, homogeneity, donor catchment, similarity index, cluster analysis

  15. An implementation of a data-transmission pipelining algorithm on Imote2 platforms

    NASA Astrophysics Data System (ADS)

    Li, Xu; Dorvash, Siavash; Cheng, Liang; Pakzad, Shamim

    2011-04-01

    Over the past several years, wireless network systems and sensing technologies have been developed significantly. This has resulted in the broad application of wireless sensor networks (WSNs) in many engineering fields and in particular structural health monitoring (SHM). The movement of traditional SHM toward the new generation of SHM, which utilizes WSNs, relies on the advantages of this new approach such as relatively low costs, ease of implementation and the capability of onboard data processing and management. In the particular case of long span bridge monitoring, a WSN should be capable of transmitting commands and measurement data over long network geometry in a reliable manner. While using single-hop data transmission in such geometry requires a long radio range and consequently a high level of power supply, multi-hop communication may offer an effective and reliable way for data transmissions across the network. Using a multi-hop communication protocol, the network relays data from a remote node to the base station via intermediary nodes. We have proposed a data-transmission pipelining algorithm to enable an effective use of the available bandwidth and minimize the energy consumption and the delay performance by the multi-hop communication protocol. This paper focuses on the implementation aspect of the pipelining algorithm on Imote2 platforms for SHM applications, describes its interaction with underlying routing protocols, and presents the solutions to various implementation issues of the proposed pipelining algorithm. Finally, the performance of the algorithm is evaluated based on the results of an experimental implementation.

  16. Damage tolerance modeling and validation of a wireless sensory composite panel for a structural health monitoring system

    NASA Astrophysics Data System (ADS)

    Talagani, Mohamad R.; Abdi, Frank; Saravanos, Dimitris; Chrysohoidis, Nikos; Nikbin, Kamran; Ragalini, Rose; Rodov, Irena

    2013-05-01

    The paper proposes the diagnostic and prognostic modeling and test validation of a Wireless Integrated Strain Monitoring and Simulation System (WISMOS). The effort verifies a hardware and web based software tool that is able to evaluate and optimize sensorized aerospace composite structures for the purpose of Structural Health Monitoring (SHM). The tool is an extension of an existing suite of an SHM system, based on a diagnostic-prognostic system (DPS) methodology. The goal of the extended SHM-DPS is to apply multi-scale nonlinear physics-based Progressive Failure analyses to the "as-is" structural configuration to determine residual strength, remaining service life, and future inspection intervals and maintenance procedures. The DPS solution meets the JTI Green Regional Aircraft (GRA) goals towards low weight, durable and reliable commercial aircraft. It will take advantage of the currently developed methodologies within the European Clean sky JTI project WISMOS, with the capability to transmit, store and process strain data from a network of wireless sensors (e.g. strain gages, FBGA) and utilize a DPS-based methodology, based on multi scale progressive failure analysis (MS-PFA), to determine structural health and to advice with respect to condition based inspection and maintenance. As part of the validation of the Diagnostic and prognostic system, Carbon/Epoxy ASTM coupons were fabricated and tested to extract the mechanical properties. Subsequently two composite stiffened panels were manufactured, instrumented and tested under compressive loading: 1) an undamaged stiffened buckling panel; and 2) a damaged stiffened buckling panel including an initial diamond cut. Next numerical Finite element models of the two panels were developed and analyzed under test conditions using Multi-Scale Progressive Failure Analysis (an extension of FEM) to evaluate the damage/fracture evolution process, as well as the identification of contributing failure modes. The comparisons between predictions and test results were within 10% accuracy.

  17. Information processing for aerospace structural health monitoring

    NASA Astrophysics Data System (ADS)

    Lichtenwalner, Peter F.; White, Edward V.; Baumann, Erwin W.

    1998-06-01

    Structural health monitoring (SHM) technology provides a means to significantly reduce life cycle of aerospace vehicles by eliminating unnecessary inspections, minimizing inspection complexity, and providing accurate diagnostics and prognostics to support vehicle life extension. In order to accomplish this, a comprehensive SHM system will need to acquire data from a wide variety of diverse sensors including strain gages, accelerometers, acoustic emission sensors, crack growth gages, corrosion sensors, and piezoelectric transducers. Significant amounts of computer processing will then be required to convert this raw sensor data into meaningful information which indicates both the diagnostics of the current structural integrity as well as the prognostics necessary for planning and managing the future health of the structure in a cost effective manner. This paper provides a description of the key types of information processing technologies required in an effective SHM system. These include artificial intelligence techniques such as neural networks, expert systems, and fuzzy logic for nonlinear modeling, pattern recognition, and complex decision making; signal processing techniques such as Fourier and wavelet transforms for spectral analysis and feature extraction; statistical algorithms for optimal detection, estimation, prediction, and fusion; and a wide variety of other algorithms for data analysis and visualization. The intent of this paper is to provide an overview of the role of information processing for SHM, discuss various technologies which can contribute to accomplishing this role, and present some example applications of information processing for SHM implemented at the Boeing Company.

  18. Performance enhanced piezoelectric-based crack detection system for high temperature I-beam SHM

    NASA Astrophysics Data System (ADS)

    Zhang, Chen; Zhang, Haifeng

    2017-04-01

    This paper proposes an innovative sensing system for high temperature (up to 150°C) I-beam crack detection. The proposed system is based on the piezoelectric effect and laser sensing mechanisms, which is proved to be effective at high temperature environment (up to 150°C). Different from other high temperature SHM approaches, the proposed sensing system is employing a piezoelectric disk as an actuator and a laser vibrometer as a sensor for remote detection. Lab tests are carried out and the vibrational properties are studied to characterize the relationship between crack depth and sensor responses by analyzing the RMS of sensor responses. Instead of utilizing a pair of piezoelectric actuator and sensor, using the laser vibrometer will enable 1) a more flexible detection, which will not be limited to specific area or dimension, 2) wireless sensing, which lowers the risk of operating at high temperature/harsh environment. The proposed sensing system can be applied to engineering structures such as in nuclear power plant reactor vessel and heat pipe structures/systems.

  19. Design and testing of integrated Bragg grating sensor systems for advanced grid structure

    NASA Astrophysics Data System (ADS)

    Amano, Masataro; Mizutani, Tadahito; Okabe, Yoji; Takeda, Nobuo; Ozaki, Tsuyoshi

    2006-03-01

    In this research, the authors target on the construction of structural health monitoring system of Advanced Grid Structure (AGS) made of Carbon fiber reinforced plastic (CFRP). AGS has often been applied to aerospace structures because of the following advantages: (1) Since ribs carry only axial forces, the weakness in the transverse direction of the CFRP unidirectional laminates is negligible. (2) AGS has damage tolerance because the fracture of a rib hardly affects other ribs, namely AGS is a fail-safe structure. In this research, in order to detect existence and regions of rib fractures in AGS, we embedded multiplexed fiber Bragg grating (FBG) sensors into AGS in rib longitudinal directions for measurement of strains. Monitoring of the change in rib longitudinal strains is the most effective SHM system for AGS. In order to confirm our proposal, we carried out following discussions. First, we analytically revealed that the change in rib longitudinal strains was the most sensitive signal for damage detection because of AGS's structural redundancy. Then, we introduced a statistical outlier analysis technique into the SHM system for damage recognition. Finally, we established AGS with the SHM system and verified experimentally. The result of the test showed that damage existence and regions in AGS could be detected with the proposed SHM system.

  20. Damage detection in bridges through fiber optic structural health monitoring

    NASA Astrophysics Data System (ADS)

    Doornink, J. D.; Phares, B. M.; Wipf, T. J.; Wood, D. L.

    2006-10-01

    A fiber optic structural health monitoring (SHM) system was developed and deployed by the Iowa State University (ISU) Bridge Engineering Center (BEC) to detect gradual or sudden damage in fracture-critical bridges (FCBs). The SHM system is trained with measured performance data, which are collected by fiber optic strain sensors to identify typical bridge behavior when subjected to ambient traffic loads. Structural responses deviating from the trained behavior are considered to be signs of structural damage or degradation and are identified through analytical procedures similar to control chart analyses used in statistical process control (SPC). The demonstration FCB SHM system was installed on the US Highway 30 bridge near Ames, IA, and utilizes 40 fiber bragg grating (FBG) sensors to continuously monitor the bridge response when subjected to ambient traffic loads. After the data is collected and processed, weekly evaluation reports are developed that summarize the continuous monitoring results. Through use of the evaluation reports, the bridge owner is able to identify and estimate the location and severity of the damage. The information presented herein includes an overview of the SHM components, results from laboratory and field validation testing on the system components, and samples of the reduced and analyzed data.

  1. Active photo-thermal self-healing of shape memory polyurethanes

    NASA Astrophysics Data System (ADS)

    Kazemi-Lari, Mohammad A.; Malakooti, Mohammad H.; Sodano, Henry A.

    2017-05-01

    Structural health monitoring (SHM) has received significant interest over the past decade and has led to the development of a wide variety of sensors and signal processing techniques to determine the presence of changes or damage in a structural system. The topic has attracted significant attention due to the safety and performance enhancing benefits as well as the potential lifesaving capabilities offered by the technology. While the resulting systems are capable of sensing their surrounding structural and environmental conditions, few methods exist for using the information to autonomously react and repair or protect the system. One of the major challenges in the future implementation of SHM systems is their coupling with materials that can react to the damage to heal themselves and return to normal function. The coupling of self-healing materials with SHM has the potential to significantly prolong the lifetime of structural systems and extend the required inspection intervals. In the present study, an optical fiber based self-healing system composed of mendable polyurethanes based on the thermally reversible Diels-Alder (DA) reaction is developed. Inspired by health monitoring techniques, active photo-thermal sensing and actuation is achieved using infrared laser light passing through an optical fiber and a thermal power sensor to detect the presence of cracking in the structure. Healing is triggered as the crack propagates through the polymer and fractures the embedded optical fiber. Through a feedback loop, the detected power drop by the sensor is utilized as a signal to heat the cracked area and stimulate the shape memory effect of the polyurethane and the retro-DA reaction. The healing performance results indicate that this novel integrated system can be effectively employed to monitor the incidence of damage and actively heal a crack in the polymer.

  2. An optimal baseline selection methodology for data-driven damage detection and temperature compensation in acousto-ultrasonics

    NASA Astrophysics Data System (ADS)

    Torres-Arredondo, M.-A.; Sierra-Pérez, Julián; Cabanes, Guénaël

    2016-05-01

    The process of measuring and analysing the data from a distributed sensor network all over a structural system in order to quantify its condition is known as structural health monitoring (SHM). For the design of a trustworthy health monitoring system, a vast amount of information regarding the inherent physical characteristics of the sources and their propagation and interaction across the structure is crucial. Moreover, any SHM system which is expected to transition to field operation must take into account the influence of environmental and operational changes which cause modifications in the stiffness and damping of the structure and consequently modify its dynamic behaviour. On that account, special attention is paid in this paper to the development of an efficient SHM methodology where robust signal processing and pattern recognition techniques are integrated for the correct interpretation of complex ultrasonic waves within the context of damage detection and identification. The methodology is based on an acousto-ultrasonics technique where the discrete wavelet transform is evaluated for feature extraction and selection, linear principal component analysis for data-driven modelling and self-organising maps for a two-level clustering under the principle of local density. At the end, the methodology is experimentally demonstrated and results show that all the damages were detectable and identifiable.

  3. Classification of damage in structural systems using time series analysis and supervised and unsupervised pattern recognition techniques

    NASA Astrophysics Data System (ADS)

    Omenzetter, Piotr; de Lautour, Oliver R.

    2010-04-01

    Developed for studying long, periodic records of various measured quantities, time series analysis methods are inherently suited and offer interesting possibilities for Structural Health Monitoring (SHM) applications. However, their use in SHM can still be regarded as an emerging application and deserves more studies. In this research, Autoregressive (AR) models were used to fit experimental acceleration time histories from two experimental structural systems, a 3- storey bookshelf-type laboratory structure and the ASCE Phase II SHM Benchmark Structure, in healthy and several damaged states. The coefficients of the AR models were chosen as damage sensitive features. Preliminary visual inspection of the large, multidimensional sets of AR coefficients to check the presence of clusters corresponding to different damage severities was achieved using Sammon mapping - an efficient nonlinear data compression technique. Systematic classification of damage into states based on the analysis of the AR coefficients was achieved using two supervised classification techniques: Nearest Neighbor Classification (NNC) and Learning Vector Quantization (LVQ), and one unsupervised technique: Self-organizing Maps (SOM). This paper discusses the performance of AR coefficients as damage sensitive features and compares the efficiency of the three classification techniques using experimental data.

  4. Ultrasonic wave-based structural health monitoring embedded instrument.

    PubMed

    Aranguren, G; Monje, P M; Cokonaj, Valerijan; Barrera, Eduardo; Ruiz, Mariano

    2013-12-01

    Piezoelectric sensors and actuators are the bridge between electronic and mechanical systems in structures. This type of sensor is a key element in the integrity monitoring of aeronautic structures, bridges, pressure vessels, wind turbine blades, and gas pipelines. In this paper, an all-in-one system for Structural Health Monitoring (SHM) based on ultrasonic waves is presented, called Phased Array Monitoring for Enhanced Life Assessment. This integrated instrument is able to generate excitation signals that are sent through piezoelectric actuators, acquire the received signals in the piezoelectric sensors, and carry out signal processing to check the health of structures. To accomplish this task, the instrument uses a piezoelectric phased-array transducer that performs the actuation and sensing of the signals. The flexibility and strength of the instrument allow the user to develop and implement a substantial part of the SHM technique using Lamb waves. The entire system is controlled using configuration software and has been validated through functional, electrical loading, mechanical loading, and thermal loading resistance tests.

  5. Distributed adaptive diagnosis of sensor faults using structural response data

    NASA Astrophysics Data System (ADS)

    Dragos, Kosmas; Smarsly, Kay

    2016-10-01

    The reliability and consistency of wireless structural health monitoring (SHM) systems can be compromised by sensor faults, leading to miscalibrations, corrupted data, or even data loss. Several research approaches towards fault diagnosis, referred to as ‘analytical redundancy’, have been proposed that analyze the correlations between different sensor outputs. In wireless SHM, most analytical redundancy approaches require centralized data storage on a server for data analysis, while other approaches exploit the on-board computing capabilities of wireless sensor nodes, analyzing the raw sensor data directly on board. However, using raw sensor data poses an operational constraint due to the limited power resources of wireless sensor nodes. In this paper, a new distributed autonomous approach towards sensor fault diagnosis based on processed structural response data is presented. The inherent correlations among Fourier amplitudes of acceleration response data, at peaks corresponding to the eigenfrequencies of the structure, are used for diagnosis of abnormal sensor outputs at a given structural condition. Representing an entirely data-driven analytical redundancy approach that does not require any a priori knowledge of the monitored structure or of the SHM system, artificial neural networks (ANN) are embedded into the sensor nodes enabling cooperative fault diagnosis in a fully decentralized manner. The distributed analytical redundancy approach is implemented into a wireless SHM system and validated in laboratory experiments, demonstrating the ability of wireless sensor nodes to self-diagnose sensor faults accurately and efficiently with minimal data traffic. Besides enabling distributed autonomous fault diagnosis, the embedded ANNs are able to adapt to the actual condition of the structure, thus ensuring accurate and efficient fault diagnosis even in case of structural changes.

  6. Locating damage using integrated global-local approach with wireless sensing system and single-chip impedance measurement device.

    PubMed

    Lin, Tzu-Hsuan; Lu, Yung-Chi; Hung, Shih-Lin

    2014-01-01

    This study developed an integrated global-local approach for locating damage on building structures. A damage detection approach with a novel embedded frequency response function damage index (NEFDI) was proposed and embedded in the Imote2.NET-based wireless structural health monitoring (SHM) system to locate global damage. Local damage is then identified using an electromechanical impedance- (EMI-) based damage detection method. The electromechanical impedance was measured using a single-chip impedance measurement device which has the advantages of small size, low cost, and portability. The feasibility of the proposed damage detection scheme was studied with reference to a numerical example of a six-storey shear plane frame structure and a small-scale experimental steel frame. Numerical and experimental analysis using the integrated global-local SHM approach reveals that, after NEFDI indicates the approximate location of a damaged area, the EMI-based damage detection approach can then identify the detailed damage location in the structure of the building.

  7. A structural health monitoring fastener for tracking fatigue crack growth in bolted metallic joints

    NASA Astrophysics Data System (ADS)

    Rakow, Alexi Schroder

    Fatigue cracks initiating at fastener hole locations in metallic components are among the most common form of airframe damage. The fastener hole site has been surveyed as the second leading initiation site for fatigue related accidents of fixed wing aircraft. Current methods for inspecting airframes for these cracks are manual, whereby inspectors rely on non-destructive inspection equipment or hand-held probes to scan over areas of a structure. Use of this equipment often demands disassembly of the vehicle to search appropriate hole locations for cracks, which elevates the complexity and cost of these maintenance inspections. Improved reliability, safety, and reduced cost of such maintenance can be realized by the permanent integration of sensors with a structure to detect this damage. Such an integrated system of sensors would form a structural health monitoring (SHM) system. In this study, an Additive, Interleaved, Multi-layer Electromagnetic (AIME) sensor was developed and integrated with the shank of a fastener to form a SHM Fastener, a new SHM technology targeted at detection of fastener hole cracks. The major advantages of the SHM Fastener are its installation, which does not require joint layer disassembly, its capability to detect inner layer cracks, and its capability to operate in a continuous autonomous mode. Two methods for fabricating the proposed SHM Fastener were studied. The first option consisted of a thin flexible printed circuit film that was bonded around a thin metallic sleeve placed around the fastener shank. The second option consisted of coating sensor materials directly to the shank of a part in an effort to increase the durability of the sensor under severe loading conditions. Both analytical and numerical models were developed to characterize the capability of the sensors and provide a design tool for the sensor layout. A diagnostic technique for crack growth monitoring was developed to complete the SHM system, which consists of the sensor, data acquisition hardware, algorithm, and diagnostic display. The AIME sensor design, SHM Fastener, and complete SHM system are presented along with experimental results from a series of single-layer and bolted double lap joint aluminum laboratory specimens to validate the capability of these sensors to monitor metallic joints for fastener hole cracks. Fatigue cracks were successfully tracked to over 0.7 inches from the fastener hole in these tests. Sensor output obtained from single-layer fatigue specimens was compared with analytical predictions for fatigue crack growth versus cycle number showing a good correlation in trend between sensor output and predicted crack size.

  8. Fiber Bragg Grating Sensor System for Monitoring Smart Composite Aerospace Structures

    NASA Technical Reports Server (NTRS)

    Moslehi, Behzad; Black, Richard J.; Gowayed, Yasser

    2012-01-01

    Lightweight, electromagnetic interference (EMI) immune, fiber-optic, sensor- based structural health monitoring (SHM) will play an increasing role in aerospace structures ranging from aircraft wings to jet engine vanes. Fiber Bragg Grating (FBG) sensors for SHM include advanced signal processing, system and damage identification, and location and quantification algorithms. Potentially, the solution could be developed into an autonomous onboard system to inspect and perform non-destructive evaluation and SHM. A novel method has been developed to massively multiplex FBG sensors, supported by a parallel processing interrogator, which enables high sampling rates combined with highly distributed sensing (up to 96 sensors per system). The interrogation system comprises several subsystems. A broadband optical source subsystem (BOSS) and routing and interface module (RIM) send light from the interrogation system to a composite embedded FBG sensor matrix, which returns measurand-dependent wavelengths back to the interrogation system for measurement with subpicometer resolution. In particular, the returned wavelengths are channeled by the RIM to a photonic signal processing subsystem based on powerful optical chips, then passed through an optoelectronic interface to an analog post-detection electronics subsystem, digital post-detection electronics subsystem, and finally via a data interface to a computer. A range of composite structures has been fabricated with FBGs embedded. Stress tensile, bending, and dynamic strain tests were performed. The experimental work proved that the FBG sensors have a good level of accuracy in measuring the static response of the tested composite coupons (down to submicrostrain levels), the capability to detect and monitor dynamic loads, and the ability to detect defects in composites by a variety of methods including monitoring the decay time under different dynamic loading conditions. In addition to quasi-static and dynamic load monitoring, the system can capture acoustic emission events that can be a prelude to structural failure, as well as piezoactuator-induced ultrasonic Lamb-waves-based techniques as a basis for damage detection.

  9. [Sociohygienic monitoring in the Russian Federation: problems and tasks].

    PubMed

    Onishchenko, G G

    2006-01-01

    The State sociohygienic monitoring (SHM) system is one of the most important mechanisms of providing sanitary-and-epidemiological well-being in the population. The March 30, 1999 Federal Law on Sanitary-and-Epidemiological Well-being of the Population" refers SHM to as one of the mechanisms of state regulation in this field and defines as a state system for monitoring the population's health and the environment, for analyzing, evaluating, and predicting them, and for revealing cause-and-effect relations between the population's health status and the influence of environmental factors. Much work has been recently done to establish and manage a federal information fund (FIF) that is a database on the human health status and environment, based on long-term observations and an aggregate of normative legal acts and reference materials on the analysis of prediction and determination of cause-and-effect relations between the human health status and the influence of environmental factors. FIF obtains information from a great many sources, including databases of state executive authorities. This information is open and available to the institutions and organizations involved in the establishment of FIF. The elaboration and introduction of new, more informative indices for SHM management at the present stage are one of the urgent tasks. In accordance with the May 28, 2000 decision of the Board of the Ministry of Health of Russia, with the 2003-2004 regulatory documents of the Ministry of Health of Russia, much work to improve the list of SHM indices has been under way. The draft list of SHM indices is harmonized with the indices of the European SHN information system, with the list of social diseases, approved by the Russian Federation's Government Regulation No. 715 dated December 1, 2004, and the list of national security threat indices (A 21-2162 dated August 29, 2003). The draft list has been considered by the specialists of the Federal Service for Surveillance of Consumers' Rights Protection and Human Well-being; comments have been taken into account. The draft is under reconsideration and will require approval in the near future.

  10. Approaches to nonlinear cointegration with a view towards applications in SHM

    NASA Astrophysics Data System (ADS)

    Cross, E. J.; Worden, K.

    2011-07-01

    One of the major problems confronting the application of Structural Health Monitoring (SHM) to real structures is that of divorcing the effect of environmental changes from those imposed by damage. A recent development in this area is the import of the technique of cointegration from the field of econometrics. While cointegration is a mature technology within economics, its development has been largely concerned with linear time-series analysis and this places a severe constraint on its application - particularly in the new context of SHM where damage can often make a given structure nonlinear. The objective of the current paper is to introduce two possible approaches to nonlinear cointegration: the first is an optimisation-based method; the second is a variation of the established Johansen procedure based on the use of an augmented basis. Finally, the ideas of nonlinear cointegration will be explored through application to real SHM data from the benchmark project on the Z24 Highway Bridge.

  11. Aspects of structural health and condition monitoring of offshore wind turbines

    PubMed Central

    Antoniadou, I.; Dervilis, N.; Papatheou, E.; Maguire, A. E.; Worden, K.

    2015-01-01

    Wind power has expanded significantly over the past years, although reliability of wind turbine systems, especially of offshore wind turbines, has been many times unsatisfactory in the past. Wind turbine failures are equivalent to crucial financial losses. Therefore, creating and applying strategies that improve the reliability of their components is important for a successful implementation of such systems. Structural health monitoring (SHM) addresses these problems through the monitoring of parameters indicative of the state of the structure examined. Condition monitoring (CM), on the other hand, can be seen as a specialized area of the SHM community that aims at damage detection of, particularly, rotating machinery. The paper is divided into two parts: in the first part, advanced signal processing and machine learning methods are discussed for SHM and CM on wind turbine gearbox and blade damage detection examples. In the second part, an initial exploration of supervisor control and data acquisition systems data of an offshore wind farm is presented, and data-driven approaches are proposed for detecting abnormal behaviour of wind turbines. It is shown that the advanced signal processing methods discussed are effective and that it is important to adopt these SHM strategies in the wind energy sector. PMID:25583864

  12. Aspects of structural health and condition monitoring of offshore wind turbines.

    PubMed

    Antoniadou, I; Dervilis, N; Papatheou, E; Maguire, A E; Worden, K

    2015-02-28

    Wind power has expanded significantly over the past years, although reliability of wind turbine systems, especially of offshore wind turbines, has been many times unsatisfactory in the past. Wind turbine failures are equivalent to crucial financial losses. Therefore, creating and applying strategies that improve the reliability of their components is important for a successful implementation of such systems. Structural health monitoring (SHM) addresses these problems through the monitoring of parameters indicative of the state of the structure examined. Condition monitoring (CM), on the other hand, can be seen as a specialized area of the SHM community that aims at damage detection of, particularly, rotating machinery. The paper is divided into two parts: in the first part, advanced signal processing and machine learning methods are discussed for SHM and CM on wind turbine gearbox and blade damage detection examples. In the second part, an initial exploration of supervisor control and data acquisition systems data of an offshore wind farm is presented, and data-driven approaches are proposed for detecting abnormal behaviour of wind turbines. It is shown that the advanced signal processing methods discussed are effective and that it is important to adopt these SHM strategies in the wind energy sector.

  13. Integration of High-Resolution Laser Displacement Sensors and 3D Printing for Structural Health Monitoring

    PubMed Central

    Chang, Shu-Wei; Kuo, Shih-Yu; Huang, Ting-Hsuan

    2017-01-01

    This paper presents a novel experimental design for complex structural health monitoring (SHM) studies achieved by integrating 3D printing technologies, high-resolution laser displacement sensors, and multiscale entropy SHM theory. A seven-story structure with a variety of composite bracing systems was constructed using a dual-material 3D printer. A wireless Bluetooth vibration speaker was used to excite the ground floor of the structure, and high-resolution laser displacement sensors (1-μm resolution) were used to monitor the displacement history on different floors. Our results showed that the multiscale entropy SHM method could detect damage on the 3D-printed structures. The results of this study demonstrate that integrating 3D printing technologies and high-resolution laser displacement sensors enables the design of cheap, fast processing, complex, small-scale civil structures for future SHM studies. The novel experimental design proposed in this study provides a suitable platform for investigating the validity and sensitivity of SHM in different composite structures and damage conditions for real life applications in the future. PMID:29271937

  14. Integration of High-Resolution Laser Displacement Sensors and 3D Printing for Structural Health Monitoring.

    PubMed

    Chang, Shu-Wei; Lin, Tzu-Kang; Kuo, Shih-Yu; Huang, Ting-Hsuan

    2017-12-22

    This paper presents a novel experimental design for complex structural health monitoring (SHM) studies achieved by integrating 3D printing technologies, high-resolution laser displacement sensors, and multiscale entropy SHM theory. A seven-story structure with a variety of composite bracing systems was constructed using a dual-material 3D printer. A wireless Bluetooth vibration speaker was used to excite the ground floor of the structure, and high-resolution laser displacement sensors (1-μm resolution) were used to monitor the displacement history on different floors. Our results showed that the multiscale entropy SHM method could detect damage on the 3D-printed structures. The results of this study demonstrate that integrating 3D printing technologies and high-resolution laser displacement sensors enables the design of cheap, fast processing, complex, small-scale civil structures for future SHM studies. The novel experimental design proposed in this study provides a suitable platform for investigating the validity and sensitivity of SHM in different composite structures and damage conditions for real life applications in the future.

  15. Load monitoring using a calibrated piezo diaphragm based impedance strain sensor and wireless sensor network in real time

    NASA Astrophysics Data System (ADS)

    Gopal Madhav Annamdas, Venu; Kiong Soh, Chee

    2017-04-01

    The last decade has seen the use of various wired-wireless and contact-contactless sensors in several structural health monitoring (SHM) techniques. Most SHM sensors that are predominantly used for strain measurements may be ineffective for damage detection and vice versa, indicating the uniapplicability of these sensors. However, piezoelectric (PE)-based macro fiber composite (MFC) and lead zirconium titanate (PZT) sensors have been on the rise in SHM, vibration and damping control, etc, due to their superior actuation and sensing abilities. These PE sensors have created much interest for their multi-applicability in various technologies such as electromechanical impedance (EMI)-based SHM. This research employs piezo diaphragms, a cheaper alternative to several expensive types of PZT/MFC sensors for the EMI technique. These piezo diaphragms were validated last year for their applicability in damage detection using the frequency domain. Here we further validate their applicability in strain monitoring using the real time domain. Hence, these piezo diaphragms can now be classified as PE sensors and used with PZT and MFC sensors in the EMI technique for monitoring damage and loading. However, no single technique or single type of sensor will be sufficient for large SHM, thus requiring the necessary deployment of more than one technique with different types of sensors such as a piezoresistive strain gauge based wireless sensor network for strain measurements to complement the EMI technique. Furthermore, we present a novel procedure of converting a regular PE sensor in the ‘frequency domain’ to ‘real time domain’ for strain applications.

  16. Nondestructive assessment of waveguides using an integrated electromechanical impedance and ultrasonic waves approach

    NASA Astrophysics Data System (ADS)

    Nasrollahi, Amir; Ma, Zhaoyun; Rizzo, Piervincenzo

    2017-04-01

    In this paper we present a structural health monitoring (SHM) paradigm based on the simultaneous use of ultrasounds and electromechanical impedance (EMI) to monitor waveguides. The paradigm uses guided ultrasonic waves (GUWs) in pitch-catch mode and EMI simultaneously. The two methodologies are driven by the same sensing/hardware/software unit. To assess the feasibility of this unified system an aluminum plate was monitored for varying damage location. Damage was simulated by adding small masses to the plate. The results associated with pitch-catch GUW testing mode were used in ultrasonic tomography, and statistical analysis was used to detect the damages using the EMI measurements. The results of GUW and EMI monitoring show that the proposed system is robust and can be developed further to address the challenges associated with the SHM of complex structures.

  17. Design of overload vehicle monitoring and response system based on DSP

    NASA Astrophysics Data System (ADS)

    Yu, Yan; Liu, Yiheng; Zhao, Xuefeng

    2014-03-01

    The overload vehicles are making much more damage to the road surface than the regular ones. Many roads and bridges are equipped with structural health monitoring system (SHM) to provide early-warning to these damage and evaluate the safety of road and bridge. However, because of the complex nature of SHM system, it's expensive to manufacture, difficult to install and not well-suited for the regular bridges and roads. Based on this application background, this paper designs a compact structural health monitoring system based on DSP, which is highly integrated, low-power, easy to install and inexpensive to manufacture. The designed system is made up of sensor arrays, the charge amplifier module, the DSP processing unit, the alarm system for overload, and the estimate for damage of the road and bridge structure. The signals coming from sensor arrays go through the charge amplifier. DSP processing unit will receive the amplified signals, estimate whether it is an overload signal or not, and convert analog variables into digital ones so that they are compatible with the back-end digital circuit for further processing. The system will also restrict certain vehicles that are overweight, by taking image of the car brand, sending the alarm, and transferring the collected pressure data to remote data center for further monitoring analysis by rain-flow counting method.

  18. Cointegration and why it works for SHM

    NASA Astrophysics Data System (ADS)

    Cross, Elizabeth J.; Worden, Keith

    2012-08-01

    One of the most fundamental problems in Structural Health Monitoring (SHM) is that of projecting out operational and environmental variations from measured feature data. The reason for this is that algorithms used for SHM to detect changes in structural condition should not raise alarms if the structure of interest changes because of benign operational or environmental variations. This is sometimes called the data normalisation problem. Many solutions to this problem have been proposed over the years, but a new approach that uses cointegration, a concept from the field of econometrics, appears to provide a very promising solution. The theory of cointegration is mathematically complex and its use is based on the holding of a number of assumptions on the time series to which it is applied. An interesting observation that has emerged from its applications to SHM data is that the approach works very well even though the aforementioned assumptions do not hold in general. The objective of the current paper is to discuss how the cointegration assumptions break down individually in the context of SHM and to explain why this does not invalidate the application of the algorithm.

  19. Numerical simulation of stress-strain state of electrophoretic shell molds

    NASA Astrophysics Data System (ADS)

    Sviridov, A. V.; Odinokov, V. I.; Dmitriev, E. A.; Evstigneev, A. I.; Bashkov, O. V.

    2017-10-01

    In the foundry engineering, castings obtained in one-piece non-gas-generating high-refractory electrophoretic shell molds (ShM) by investment patterns (IP) have an increased rejects percentage associated with low deformation resistance and crack resistance of the SM at different stages of their formation and manufacturing. Crack resistance of the ShM based on IP depends mainly on their stress-strain state (SSS) at various stages of mold forming. SSS decrease significantly improves their crack resistance and decreases their rejects percentage of castings occurring due to clogging and surface defects. In addition, the known methods of decreasing the SSS are still poorly understood. Thus, current research trends are to determine SSS at each stage of ShM forming and develop the ways to decrease it. Theoretical predicting of crack formation in multiple-layer axisymmetric shell molds is given in the work [1], and SSS of multiple-layer axisymmetric shell molds is given in the work [2]. Monolayer electrophoretic ShM had a lack of concern in this field, thus it became an argument for the present workMathematical Model of ShM SSS

  20. Development of a structural health monitoring system for the life assessment of critical transportation infrastructure.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Roach, Dennis Patrick; Jauregui, David Villegas; Daumueller, Andrew Nicholas

    2012-02-01

    Recent structural failures such as the I-35W Mississippi River Bridge in Minnesota have underscored the urgent need for improved methods and procedures for evaluating our aging transportation infrastructure. This research seeks to develop a basis for a Structural Health Monitoring (SHM) system to provide quantitative information related to the structural integrity of metallic structures to make appropriate management decisions and ensuring public safety. This research employs advanced structural analysis and nondestructive testing (NDT) methods for an accurate fatigue analysis. Metal railroad bridges in New Mexico will be the focus since many of these structures are over 100 years old andmore » classified as fracture-critical. The term fracture-critical indicates that failure of a single component may result in complete collapse of the structure such as the one experienced by the I-35W Bridge. Failure may originate from sources such as loss of section due to corrosion or cracking caused by fatigue loading. Because standard inspection practice is primarily visual, these types of defects can go undetected due to oversight, lack of access to critical areas, or, in riveted members, hidden defects that are beneath fasteners or connection angles. Another issue is that it is difficult to determine the fatigue damage that a structure has experienced and the rate at which damage is accumulating due to uncertain history and load distribution in supporting members. A SHM system has several advantages that can overcome these limitations. SHM allows critical areas of the structure to be monitored more quantitatively under actual loading. The research needed to apply SHM to metallic structures was performed and a case study was carried out to show the potential of SHM-driven fatigue evaluation to assess the condition of critical transportation infrastructure and to guide inspectors to potential problem areas. This project combines the expertise in transportation infrastructure at New Mexico State University with the expertise at Sandia National Laboratories in the emerging field of SHM.« less

  1. Reframing measurement for structural health monitoring: a full-field strategy for structural identification

    NASA Astrophysics Data System (ADS)

    Dizaji, Mehrdad S.; Harris, Devin K.; Alipour, Mohamad; Ozbulut, Osman E.

    2018-03-01

    Structural health monitoring (SHM) describes a decision-making framework that is fundamentally guided by state change detection of structural systems. This framework typically relies on the use of continuous or semi-continuous monitoring of measured response to quantify this state change in structural system behavior, which is often related to the initiation of some form of damage. Measurement approaches used for traditional SHM are numerous, but most are limited to either describing localized or global phenomena, making it challenging to characterize operational structural systems which exhibit both. In addition to these limitations in sensing, SHM has also suffered from the inherent robustness inherent to most full-scale structural systems, making it challenging to identify local damage. These challenges highlight the opportunity for alternative strategies for SHM, strategies that are able to provide data suitable to translate into rich information. This paper describes preliminary results from a refined structural identification (St-ID) approach using fullfield measurements derived from high-speed 3D Digital Image Correlation (HSDIC) to characterize uncertain parameters (i.e. boundary and constitutive properties) of a laboratory scale structural component. The St-ID approach builds from prior work by supplementing full-field deflection and strain response with vibration response derived from HSDIC. Inclusion of the modal characteristics within a hybrid-genetic algorithm optimization scheme allowed for simultaneous integration of mechanical and modal response, thus enabling a more robust St-ID strategy than could be achieved with traditional sensing techniques. The use of full-field data is shown to provide a more comprehensive representation of the global and local behavior, which in turn increases the robustness of the St-Id framework. This work serves as the foundation for a new paradigm in SHM that emphasizes characterizing structural performance using a smaller number, but richer set of measurements.

  2. Structural Health Monitoring: Leveraging Pain in the Human Body

    NASA Astrophysics Data System (ADS)

    Nayak, Subhadarshi

    2012-07-01

    Tissue damage, or the perception thereof, is managed through pain experience. The neurobiological process of pain triggers most effective defense mechanisms for our safety. Structural health monitoring (SHM) is also a very similar function, albeit in engineering systems. SHM technology can leverage many aspects of pain mechanisms to progress in several critical areas. Discrimination between features from the undamaged and damaged structures can follow the threshold gate mechanism of the pain perception. Furthermore, the sensing mechanisms can be adaptive to changes by adjusting the threshold as does the pain perception. A distributed sensor network, often advanced by SHM, can be made fault-tolerant and robust by following the perception way of self-organization and redundancy. Data handling in real life is a huge challenge for large-scale SHM. As sensory data of pain is first cleaned, the threshold is then processed through experiential information gathering and use.

  3. Application of structural health monitoring technologies to bio-systems: current status and path forward

    NASA Astrophysics Data System (ADS)

    Bhalla, Suresh; Srivastava, Shashank; Suresh, Rupali; Moharana, Sumedha; Kaur, Naveet; Gupta, Ashok

    2015-03-01

    This paper presents a case for extension of structural health monitoring (SHM) technologies to offer solutions for biomedical problems. SHM research has made remarkable progress during the last two/ three decades. These technologies are now being extended for possible applications in the bio-medical field. Especially, smart materials, such as piezoelectric ceramic (PZT) patches and fibre-Bragg grating (FBG) sensors, offer a new set of possibilities to the bio-medical community to augment their conventional set of sensors, tools and equipment. The paper presents some of the recent extensions of SHM, such as condition monitoring of bones, monitoring of dental implant post surgery and foot pressure measurement. Latest developments, such as non-bonded configuration of PZT patches for monitoring bones and possible applications in osteoporosis detection, are also discussed. In essence, there is a whole new gamut of new possibilities for SHM technologies making their foray into the bi-medical sector.

  4. A Multi-Level Decision Fusion Strategy for Condition Based Maintenance of Composite Structures

    PubMed Central

    Sharif Khodaei, Zahra; Aliabadi, M.H.

    2016-01-01

    In this work, a multi-level decision fusion strategy is proposed which weighs the Value of Information (VoI) against the intended functions of a Structural Health Monitoring (SHM) system. This paper presents a multi-level approach for three different maintenance strategies in which the performance of the SHM systems is evaluated against its intended functions. Level 1 diagnosis results in damage existence with minimum sensors covering a large area by finding the maximum energy difference for the guided waves propagating in pristine structure and the post-impact state; Level 2 diagnosis provides damage detection and approximate localization using an approach based on Electro-Mechanical Impedance (EMI) measures, while Level 3 characterizes damage (exact location and size) in addition to its detection by utilising a Weighted Energy Arrival Method (WEAM). The proposed multi-level strategy is verified and validated experimentally by detection of Barely Visible Impact Damage (BVID) on a curved composite fuselage panel. PMID:28773910

  5. Theoretical Background and Prognostic Modeling for Benchmarking SHM Sensors for Composite Structures

    DTIC Science & Technology

    2010-10-01

    minimum flaw size can be detected by the existing SHM based monitoring methods. Sandwich panels with foam , WebCore and honeycomb structures were...Whether it be hat stiffened, corrugated sandwich, honeycomb sandwich, or foam filled sandwich, all composite structures have one basic handicap in...based monitoring methods. Sandwich panels with foam , WebCore and honeycomb structures were considered for use in this study. Eigenmode frequency

  6. Developing a structural health monitoring system for nuclear dry cask storage canister

    NASA Astrophysics Data System (ADS)

    Sun, Xiaoyi; Lin, Bin; Bao, Jingjing; Giurgiutiu, Victor; Knight, Travis; Lam, Poh-Sang; Yu, Lingyu

    2015-03-01

    Interim storage of spent nuclear fuel from reactor sites has gained additional importance and urgency for resolving waste-management-related technical issues. In total, there are over 1482 dry cask storage system (DCSS) in use at US plants, storing 57,807 fuel assemblies. Nondestructive material condition monitoring is in urgent need and must be integrated into the fuel cycle to quantify the "state of health", and more importantly, to guarantee the safe operation of radioactive waste storage systems (RWSS) during their extended usage period. A state-of-the-art nuclear structural health monitoring (N-SHM) system based on in-situ sensing technologies that monitor material degradation and aging for nuclear spent fuel DCSS and similar structures is being developed. The N-SHM technology uses permanently installed low-profile piezoelectric wafer sensors to perform long-term health monitoring by strategically using a combined impedance (EMIS), acoustic emission (AE), and guided ultrasonic wave (GUW) approach, called "multimode sensing", which is conducted by the same network of installed sensors activated in a variety of ways. The system will detect AE events resulting from crack (case for study in this project) and evaluate the damage evolution; when significant AE is detected, the sensor network will switch to the GUW mode to perform damage localization, and quantification as well as probe "hot spots" that are prone to damage for material degradation evaluation using EMIS approach. The N-SHM is expected to eventually provide a systematic methodology for assessing and monitoring nuclear waste storage systems without incurring human radiation exposure.

  7. Antigen Receptor Galaxy: A User-Friendly, Web-Based Tool for Analysis and Visualization of T and B Cell Receptor Repertoire Data

    PubMed Central

    IJspeert, Hanna; van Schouwenburg, Pauline A.; van Zessen, David; Pico-Knijnenburg, Ingrid

    2017-01-01

    Antigen Receptor Galaxy (ARGalaxy) is a Web-based tool for analyses and visualization of TCR and BCR sequencing data of 13 species. ARGalaxy consists of four parts: the demultiplex tool, the international ImMunoGeneTics information system (IMGT) concatenate tool, the immune repertoire pipeline, and the somatic hypermutation (SHM) and class switch recombination (CSR) pipeline. Together they allow the analysis of all different aspects of the immune repertoire. All pipelines can be run independently or combined, depending on the available data and the question of interest. The demultiplex tool allows data trimming and demultiplexing, whereas with the concatenate tool multiple IMGT/HighV-QUEST output files can be merged into a single file. The immune repertoire pipeline is an extended version of our previously published ImmunoGlobulin Galaxy (IGGalaxy) virtual machine that was developed to visualize V(D)J gene usage. It allows analysis of both BCR and TCR rearrangements, visualizes CDR3 characteristics (length and amino acid usage) and junction characteristics, and calculates the diversity of the immune repertoire. Finally, ARGalaxy includes the newly developed SHM and CSR pipeline to analyze SHM and/or CSR in BCR rearrangements. It analyzes the frequency and patterns of SHM, Ag selection (including BASELINe), clonality (Change-O), and CSR. The functionality of the ARGalaxy tool is illustrated in several clinical examples of patients with primary immunodeficiencies. In conclusion, ARGalaxy is a novel tool for the analysis of the complete immune repertoire, which is applicable to many patient groups with disturbances in the immune repertoire such as autoimmune diseases, allergy, and leukemia, but it can also be used to address basic research questions in repertoire formation and selection. PMID:28416602

  8. A Sensor Data Fusion System Based on k-Nearest Neighbor Pattern Classification for Structural Health Monitoring Applications

    PubMed Central

    Vitola, Jaime; Pozo, Francesc; Tibaduiza, Diego A.; Anaya, Maribel

    2017-01-01

    Civil and military structures are susceptible and vulnerable to damage due to the environmental and operational conditions. Therefore, the implementation of technology to provide robust solutions in damage identification (by using signals acquired directly from the structure) is a requirement to reduce operational and maintenance costs. In this sense, the use of sensors permanently attached to the structures has demonstrated a great versatility and benefit since the inspection system can be automated. This automation is carried out with signal processing tasks with the aim of a pattern recognition analysis. This work presents the detailed description of a structural health monitoring (SHM) system based on the use of a piezoelectric (PZT) active system. The SHM system includes: (i) the use of a piezoelectric sensor network to excite the structure and collect the measured dynamic response, in several actuation phases; (ii) data organization; (iii) advanced signal processing techniques to define the feature vectors; and finally; (iv) the nearest neighbor algorithm as a machine learning approach to classify different kinds of damage. A description of the experimental setup, the experimental validation and a discussion of the results from two different structures are included and analyzed. PMID:28230796

  9. A Sensor Data Fusion System Based on k-Nearest Neighbor Pattern Classification for Structural Health Monitoring Applications.

    PubMed

    Vitola, Jaime; Pozo, Francesc; Tibaduiza, Diego A; Anaya, Maribel

    2017-02-21

    Civil and military structures are susceptible and vulnerable to damage due to the environmental and operational conditions. Therefore, the implementation of technology to provide robust solutions in damage identification (by using signals acquired directly from the structure) is a requirement to reduce operational and maintenance costs. In this sense, the use of sensors permanently attached to the structures has demonstrated a great versatility and benefit since the inspection system can be automated. This automation is carried out with signal processing tasks with the aim of a pattern recognition analysis. This work presents the detailed description of a structural health monitoring (SHM) system based on the use of a piezoelectric (PZT) active system. The SHM system includes: (i) the use of a piezoelectric sensor network to excite the structure and collect the measured dynamic response, in several actuation phases; (ii) data organization; (iii) advanced signal processing techniques to define the feature vectors; and finally; (iv) the nearest neighbor algorithm as a machine learning approach to classify different kinds of damage. A description of the experimental setup, the experimental validation and a discussion of the results from two different structures are included and analyzed.

  10. Optical Fiber Distributed Sensing Structural Health Monitoring (SHM) Strain Measurements Taken During Cryotank Y-Joint Test Article Load Cycling at Liquid Helium Temperatures

    NASA Technical Reports Server (NTRS)

    Allison, Sidney G.; Prosser, William H.; Hare, David A.; Moore, Thomas C.; Kenner, Winfred S.

    2007-01-01

    This paper outlines cryogenic Y-joint testing at Langley Research Center (LaRC) to validate the performance of optical fiber Bragg grating strain sensors for measuring strain at liquid helium temperature (-240 C). This testing also verified survivability of fiber sensors after experiencing 10 thermal cool-down, warm-up cycles and 400 limit load cycles. Graphite composite skins bonded to a honeycomb substrate in a sandwich configuration comprised the Y-joint specimens. To enable SHM of composite cryotanks for consideration to future spacecraft, a light-weight, durable monitoring technology is needed. The fiber optic distributed Bragg grating strain sensing system developed at LaRC is a viable substitute for conventional strain gauges which are not practical for SHM. This distributed sensing technology uses an Optical Frequency Domain Reflectometer (OFDR). This measurement approach has the advantage that it can measure hundreds of Bragg grating sensors per fiber and the sensors are all written at one frequency, greatly simplifying fiber manufacturing. Fiber optic strain measurements compared well to conventional strain gauge measurements obtained during these tests. These results demonstrated a high potential for a successful implementation of a SHM system incorporating LaRC's fiber optic sensing system on the composite cryotank and other future cryogenic applications.

  11. Advances in Micromechanics Modeling of Composites Structures for Structural Health Monitoring

    NASA Astrophysics Data System (ADS)

    Moncada, Albert

    Although high performance, light-weight composites are increasingly being used in applications ranging from aircraft, rotorcraft, weapon systems and ground vehicles, the assurance of structural reliability remains a critical issue. In composites, damage is absorbed through various fracture processes, including fiber failure, matrix cracking and delamination. An important element in achieving reliable composite systems is a strong capability of assessing and inspecting physical damage of critical structural components. Installation of a robust Structural Health Monitoring (SHM) system would be very valuable in detecting the onset of composite failure. A number of major issues still require serious attention in connection with the research and development aspects of sensor-integrated reliable SHM systems for composite structures. In particular, the sensitivity of currently available sensor systems does not allow detection of micro level damage; this limits the capability of data driven SHM systems. As a fundamental layer in SHM, modeling can provide in-depth information on material and structural behavior for sensing and detection, as well as data for learning algorithms. This dissertation focuses on the development of a multiscale analysis framework, which is used to detect various forms of damage in complex composite structures. A generalized method of cells based micromechanics analysis, as implemented in NASA's MAC/GMC code, is used for the micro-level analysis. First, a baseline study of MAC/GMC is performed to determine the governing failure theories that best capture the damage progression. The deficiencies associated with various layups and loading conditions are addressed. In most micromechanics analysis, a representative unit cell (RUC) with a common fiber packing arrangement is used. The effect of variation in this arrangement within the RUC has been studied and results indicate this variation influences the macro-scale effective material properties and failure stresses. The developed model has been used to simulate impact damage in a composite beam and an airfoil structure. The model data was verified through active interrogation using piezoelectric sensors. The multiscale model was further extended to develop a coupled damage and wave attenuation model, which was used to study different damage states such as fiber-matrix debonding in composite structures with surface bonded piezoelectric sensors.

  12. The Single Habitat Module Concept for Exploration - Mission Planning and Mass Estimates

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe

    2013-01-01

    The Single Habitat Module (SHM) concept approach to the infrastructure and conduct of exploration missions combines many of the new promising technologies with a central concept of mission architectures that use a single habitat module for all phases of an exploration mission. Integrating mission elements near Earth and fully fueling them prior to departure of the vicinity of Earth provides the capability of using the single habitat both in transit to an exploration destination and while exploring the destination. The concept employs the capability to return the habitat and interplanetary propulsion system to Earth vicinity so that those elements can be reused on subsequent exploration missions. This paper provides a review of the SHM concept, the advantages it provides, trajectory assessments related to use of a high specific impulse space based propulsion system, advances in mission planning and new mass estimates.

  13. Wireless and real-time structural damage detection: A novel decentralized method for wireless sensor networks

    NASA Astrophysics Data System (ADS)

    Avci, Onur; Abdeljaber, Osama; Kiranyaz, Serkan; Hussein, Mohammed; Inman, Daniel J.

    2018-06-01

    Being an alternative to conventional wired sensors, wireless sensor networks (WSNs) are extensively used in Structural Health Monitoring (SHM) applications. Most of the Structural Damage Detection (SDD) approaches available in the SHM literature are centralized as they require transferring data from all sensors within the network to a single processing unit to evaluate the structural condition. These methods are found predominantly feasible for wired SHM systems; however, transmission and synchronization of huge data sets in WSNs has been found to be arduous. As such, the application of centralized methods with WSNs has been a challenge for engineers. In this paper, the authors are presenting a novel application of 1D Convolutional Neural Networks (1D CNNs) on WSNs for SDD purposes. The SDD is successfully performed completely wireless and real-time under ambient conditions. As a result of this, a decentralized damage detection method suitable for wireless SHM systems is proposed. The proposed method is based on 1D CNNs and it involves training an individual 1D CNN for each wireless sensor in the network in a format where each CNN is assigned to process the locally-available data only, eliminating the need for data transmission and synchronization. The proposed damage detection method operates directly on the raw ambient vibration condition signals without any filtering or preprocessing. Moreover, the proposed approach requires minimal computational time and power since 1D CNNs merge both feature extraction and classification tasks into a single learning block. This ability is prevailingly cost-effective and evidently practical in WSNs considering the hardware systems have been occasionally reported to suffer from limited power supply in these networks. To display the capability and verify the success of the proposed method, large-scale experiments conducted on a laboratory structure equipped with a state-of-the-art WSN are reported.

  14. A Review of the Piezoelectric Electromechanical Impedance Based Structural Health Monitoring Technique for Engineering Structures.

    PubMed

    Na, Wongi S; Baek, Jongdae

    2018-04-24

    The birth of smart materials such as piezoelectric (PZT) transducers has aided in revolutionizing the field of structural health monitoring (SHM) based on non-destructive testing (NDT) methods. While a relatively new NDT method known as the electromechanical (EMI) technique has been investigated for more than two decades, there are still various problems that must be solved before it is applied to real structures. The technique, which has a significant potential to contribute to the creation of one of the most effective SHM systems, involves the use of a single PZT for exciting and sensing of the host structure. In this paper, studies applied for the past decade related to the EMI technique have been reviewed to understand its trend. In addition, new concepts and ideas proposed by various authors are also surveyed, and the paper concludes with a discussion of the potential directions for future works.

  15. A Review of the Piezoelectric Electromechanical Impedance Based Structural Health Monitoring Technique for Engineering Structures

    PubMed Central

    Na, Wongi S.; Baek, Jongdae

    2018-01-01

    The birth of smart materials such as piezoelectric (PZT) transducers has aided in revolutionizing the field of structural health monitoring (SHM) based on non-destructive testing (NDT) methods. While a relatively new NDT method known as the electromechanical (EMI) technique has been investigated for more than two decades, there are still various problems that must be solved before it is applied to real structures. The technique, which has a significant potential to contribute to the creation of one of the most effective SHM systems, involves the use of a single PZT for exciting and sensing of the host structure. In this paper, studies applied for the past decade related to the EMI technique have been reviewed to understand its trend. In addition, new concepts and ideas proposed by various authors are also surveyed, and the paper concludes with a discussion of the potential directions for future works. PMID:29695067

  16. Best practices for evaluating the capability of nondestructive evaluation (NDE) and structural health monitoring (SHM) techniques for damage characterization

    NASA Astrophysics Data System (ADS)

    Aldrin, John C.; Annis, Charles; Sabbagh, Harold A.; Lindgren, Eric A.

    2016-02-01

    A comprehensive approach to NDE and SHM characterization error (CE) evaluation is presented that follows the framework of the `ahat-versus-a' regression analysis for POD assessment. Characterization capability evaluation is typically more complex with respect to current POD evaluations and thus requires engineering and statistical expertise in the model-building process to ensure all key effects and interactions are addressed. Justifying the statistical model choice with underlying assumptions is key. Several sizing case studies are presented with detailed evaluations of the most appropriate statistical model for each data set. The use of a model-assisted approach is introduced to help assess the reliability of NDE and SHM characterization capability under a wide range of part, environmental and damage conditions. Best practices of using models are presented for both an eddy current NDE sizing and vibration-based SHM case studies. The results of these studies highlight the general protocol feasibility, emphasize the importance of evaluating key application characteristics prior to the study, and demonstrate an approach to quantify the role of varying SHM sensor durability and environmental conditions on characterization performance.

  17. Running Gaussian16 Software Jobs on the Peregrine System | High-Performance

    Science.gov Websites

    , parallel setup is taken care of automatically based on settings in the PBS script example below. Previous filesystem called /dev/shm. This scratch space is set automatically by the example script below. The Gaussian system. An example script for batch submission is given below. #!/bin/bash #PBS -l nodes=2 #PBS -l

  18. Towards Real-time, On-board, Hardware-Supported Sensor and Software Health Management for Unmanned Aerial Systems

    NASA Technical Reports Server (NTRS)

    Schumann, Johann; Rozier, Kristin Y.; Reinbacher, Thomas; Mengshoel, Ole J.; Mbaya, Timmy; Ippolito, Corey

    2013-01-01

    Unmanned aerial systems (UASs) can only be deployed if they can effectively complete their missions and respond to failures and uncertain environmental conditions while maintaining safety with respect to other aircraft as well as humans and property on the ground. In this paper, we design a real-time, on-board system health management (SHM) capability to continuously monitor sensors, software, and hardware components for detection and diagnosis of failures and violations of safety or performance rules during the flight of a UAS. Our approach to SHM is three-pronged, providing: (1) real-time monitoring of sensor and/or software signals; (2) signal analysis, preprocessing, and advanced on the- fly temporal and Bayesian probabilistic fault diagnosis; (3) an unobtrusive, lightweight, read-only, low-power realization using Field Programmable Gate Arrays (FPGAs) that avoids overburdening limited computing resources or costly re-certification of flight software due to instrumentation. Our implementation provides a novel approach of combining modular building blocks, integrating responsive runtime monitoring of temporal logic system safety requirements with model-based diagnosis and Bayesian network-based probabilistic analysis. We demonstrate this approach using actual data from the NASA Swift UAS, an experimental all-electric aircraft.

  19. Fatigue crack detection and identification by the elastic wave propagation method

    NASA Astrophysics Data System (ADS)

    Stawiarski, Adam; Barski, Marek; Pająk, Piotr

    2017-05-01

    In this paper the elastic wave propagation phenomenon was used to detect the initiation of the fatigue damage in isotropic plate with a circular hole. The safety and reliability of structures mostly depend on the effectiveness of the monitoring methods. The Structural Health Monitoring (SHM) system based on the active pitch-catch measurement technique was proposed. The piezoelectric (PZT) elements was used as an actuators and sensors in the multipoint measuring system. The comparison of the intact and defected structures has been used by damage detection algorithm. One part of the SHM system has been responsible for detection of the fatigue crack initiation. The second part observed the evolution of the damage growth and assess the size of the defect. The numerical results of the wave propagation phenomenon has been used to present the effectiveness and accuracy of the proposed method. The preliminary experimental analysis has been carried out during the tension test of the aluminum plate with a circular hole to determine the efficiency of the measurement technique.

  20. A Tensor-Based Structural Damage Identification and Severity Assessment

    PubMed Central

    Anaissi, Ali; Makki Alamdari, Mehrisadat; Rakotoarivelo, Thierry; Khoa, Nguyen Lu Dang

    2018-01-01

    Early damage detection is critical for a large set of global ageing infrastructure. Structural Health Monitoring systems provide a sensor-based quantitative and objective approach to continuously monitor these structures, as opposed to traditional engineering visual inspection. Analysing these sensed data is one of the major Structural Health Monitoring (SHM) challenges. This paper presents a novel algorithm to detect and assess damage in structures such as bridges. This method applies tensor analysis for data fusion and feature extraction, and further uses one-class support vector machine on this feature to detect anomalies, i.e., structural damage. To evaluate this approach, we collected acceleration data from a sensor-based SHM system, which we deployed on a real bridge and on a laboratory specimen. The results show that our tensor method outperforms a state-of-the-art approach using the wavelet energy spectrum of the measured data. In the specimen case, our approach succeeded in detecting 92.5% of induced damage cases, as opposed to 61.1% for the wavelet-based approach. While our method was applied to bridges, its algorithm and computation can be used on other structures or sensor-data analysis problems, which involve large series of correlated data from multiple sensors. PMID:29301314

  1. An Online Gravity Modeling Method Applied for High Precision Free-INS

    PubMed Central

    Wang, Jing; Yang, Gongliu; Li, Jing; Zhou, Xiao

    2016-01-01

    For real-time solution of inertial navigation system (INS), the high-degree spherical harmonic gravity model (SHM) is not applicable because of its time and space complexity, in which traditional normal gravity model (NGM) has been the dominant technique for gravity compensation. In this paper, a two-dimensional second-order polynomial model is derived from SHM according to the approximate linear characteristic of regional disturbing potential. Firstly, deflections of vertical (DOVs) on dense grids are calculated with SHM in an external computer. And then, the polynomial coefficients are obtained using these DOVs. To achieve global navigation, the coefficients and applicable region of polynomial model are both updated synchronously in above computer. Compared with high-degree SHM, the polynomial model takes less storage and computational time at the expense of minor precision. Meanwhile, the model is more accurate than NGM. Finally, numerical test and INS experiment show that the proposed method outperforms traditional gravity models applied for high precision free-INS. PMID:27669261

  2. An Online Gravity Modeling Method Applied for High Precision Free-INS.

    PubMed

    Wang, Jing; Yang, Gongliu; Li, Jing; Zhou, Xiao

    2016-09-23

    For real-time solution of inertial navigation system (INS), the high-degree spherical harmonic gravity model (SHM) is not applicable because of its time and space complexity, in which traditional normal gravity model (NGM) has been the dominant technique for gravity compensation. In this paper, a two-dimensional second-order polynomial model is derived from SHM according to the approximate linear characteristic of regional disturbing potential. Firstly, deflections of vertical (DOVs) on dense grids are calculated with SHM in an external computer. And then, the polynomial coefficients are obtained using these DOVs. To achieve global navigation, the coefficients and applicable region of polynomial model are both updated synchronously in above computer. Compared with high-degree SHM, the polynomial model takes less storage and computational time at the expense of minor precision. Meanwhile, the model is more accurate than NGM. Finally, numerical test and INS experiment show that the proposed method outperforms traditional gravity models applied for high precision free-INS.

  3. Structural health monitoring for DOT using magnetic shape memory alloy cables in concrete

    NASA Astrophysics Data System (ADS)

    Davis, Allen; Mirsayar, Mirmilad; Sheahan, Emery; Hartl, Darren

    2018-03-01

    Embedding shape memory alloy (SMA) wires in concrete components offers the potential to monitor their structural health via external magnetic field sensing. Currently, structural health monitoring (SHM) is dominated by acoustic emission and vibration-based methods. Thus, it is attractive to pursue alternative damage sensing techniques that may lower the cost or increase the accuracy of SHM. In this work, SHM via magnetic field detection applied to embedded magnetic shape memory alloy (MSMA) is demonstrated both experimentally and using computational models. A concrete beam containing iron-based MSMA wire is subjected to a 3-point bend test where structural damage is induced, thereby resulting in a localized phase change of the MSMA wire. Magnetic field lines passing through the embedded MSMA domain are altered by this phase change and can thus be used to detect damage within the structure. A good correlation is observed between the computational and experimental results. Additionally, the implementation of stranded MSMA cables in place of the MSMA wire is assessed through similar computational models. The combination of these computational models and their subsequent experimental validation provide sufficient support for the feasibility of SHM using magnetic field sensing via MSMA embedded components.

  4. An experimental study on the effect of temperature on piezoelectric sensors for impedance-based structural health monitoring.

    PubMed

    Baptista, Fabricio G; Budoya, Danilo E; de Almeida, Vinicius A D; Ulson, Jose Alfredo C

    2014-01-10

    The electromechanical impedance (EMI) technique is considered to be one of the most promising methods for developing structural health monitoring (SHM) systems. This technique is simple to implement and uses small and inexpensive piezoelectric sensors. However, practical problems have hindered its application to real-world structures, and temperature effects have been cited in the literature as critical problems. In this paper, we present an experimental study of the effect of temperature on the electrical impedance of the piezoelectric sensors used in the EMI technique. We used 5H PZT (lead zirconate titanate) ceramic sensors, which are commonly used in the EMI technique. The experimental results showed that the temperature effects were strongly frequency-dependent, which may motivate future research in the SHM field.

  5. Use of Savitzky-Golay Filter for Performances Improvement of SHM Systems Based on Neural Networks and Distributed PZT Sensors.

    PubMed

    de Oliveira, Mario A; Araujo, Nelcileno V S; da Silva, Rodolfo N; da Silva, Tony I; Epaarachchi, Jayantha

    2018-01-08

    A considerable amount of research has focused on monitoring structural damage using Structural Health Monitoring (SHM) technologies, which has had recent advances. However, it is important to note the challenges and unresolved problems that disqualify currently developed monitoring systems. One of the frontline SHM technologies, the Electromechanical Impedance (EMI) technique, has shown its potential to overcome remaining problems and challenges. Unfortunately, the recently developed neural network algorithms have not shown significant improvements in the accuracy of rate and the required processing time. In order to fill this gap in advanced neural networks used with EMI techniques, this paper proposes an enhanced and reliable strategy for improving the structural damage detection via: (1) Savitzky-Golay (SG) filter, using both first and second derivatives; (2) Probabilistic Neural Network (PNN); and, (3) Simplified Fuzzy ARTMAP Network (SFAN). Those three methods were employed to analyze the EMI data experimentally obtained from an aluminum plate containing three attached PZT (Lead Zirconate Titanate) patches. In this present study, the damage scenarios were simulated by attaching a small metallic nut at three different positions in the aluminum plate. We found that the proposed method achieves a hit rate of more than 83%, which is significantly higher than current state-of-the-art approaches. Furthermore, this approach results in an improvement of 93% when considering the best case scenario.

  6. Use of Savitzky–Golay Filter for Performances Improvement of SHM Systems Based on Neural Networks and Distributed PZT Sensors

    PubMed Central

    Araujo, Nelcileno V. S.; da Silva, Rodolfo N.; da Silva, Tony I.; Epaarachchi, Jayantha

    2018-01-01

    A considerable amount of research has focused on monitoring structural damage using Structural Health Monitoring (SHM) technologies, which has had recent advances. However, it is important to note the challenges and unresolved problems that disqualify currently developed monitoring systems. One of the frontline SHM technologies, the Electromechanical Impedance (EMI) technique, has shown its potential to overcome remaining problems and challenges. Unfortunately, the recently developed neural network algorithms have not shown significant improvements in the accuracy of rate and the required processing time. In order to fill this gap in advanced neural networks used with EMI techniques, this paper proposes an enhanced and reliable strategy for improving the structural damage detection via: (1) Savitzky–Golay (SG) filter, using both first and second derivatives; (2) Probabilistic Neural Network (PNN); and, (3) Simplified Fuzzy ARTMAP Network (SFAN). Those three methods were employed to analyze the EMI data experimentally obtained from an aluminum plate containing three attached PZT (Lead Zirconate Titanate) patches. In this present study, the damage scenarios were simulated by attaching a small metallic nut at three different positions in the aluminum plate. We found that the proposed method achieves a hit rate of more than 83%, which is significantly higher than current state-of-the-art approaches. Furthermore, this approach results in an improvement of 93% when considering the best case scenario. PMID:29316693

  7. Development of a High-Sensitivity Wireless Accelerometer for Structural Health Monitoring

    PubMed Central

    Zhu, Li; Fu, Yuguang; Chow, Raymond; Spencer, Billie F.; Park, Jong Woong; Mechitov, Kirill

    2018-01-01

    Structural health monitoring (SHM) is playing an increasingly important role in ensuring the safety of structures. A shift of SHM research away from traditional wired methods toward the use of wireless smart sensors (WSS) has been motivated by the attractive features of wireless smart sensor networks (WSSN). The progress achieved in Micro Electro-Mechanical System (MEMS) technologies and wireless data transmission, has extended the effectiveness and range of applicability of WSSNs. One of the most common sensors employed in SHM strategies is the accelerometer; however, most accelerometers in WSS nodes have inadequate resolution for measurement of the typical accelerations found in many SHM applications. In this study, a high-resolution and low-noise tri-axial digital MEMS accelerometer is incorporated in a next-generation WSS platform, the Xnode. In addition to meeting the acceleration sensing demands of large-scale civil infrastructure applications, this new WSS node provides powerful hardware and a robust software framework to enable edge computing that can deliver actionable information. Hardware and software integration challenges are presented, and the associate resolutions are discussed. The performance of the wireless accelerometer is demonstrated experimentally through comparison with high-sensitivity wired accelerometers. This new high-sensitivity wireless accelerometer will extend the use of WSSN to a broader class of SHM applications. PMID:29342102

  8. Development of a High-Sensitivity Wireless Accelerometer for Structural Health Monitoring.

    PubMed

    Zhu, Li; Fu, Yuguang; Chow, Raymond; Spencer, Billie F; Park, Jong Woong; Mechitov, Kirill

    2018-01-17

    Structural health monitoring (SHM) is playing an increasingly important role in ensuring the safety of structures. A shift of SHM research away from traditional wired methods toward the use of wireless smart sensors (WSS) has been motivated by the attractive features of wireless smart sensor networks (WSSN). The progress achieved in Micro Electro-Mechanical System (MEMS) technologies and wireless data transmission, has extended the effectiveness and range of applicability of WSSNs. One of the most common sensors employed in SHM strategies is the accelerometer; however, most accelerometers in WSS nodes have inadequate resolution for measurement of the typical accelerations found in many SHM applications. In this study, a high-resolution and low-noise tri-axial digital MEMS accelerometer is incorporated in a next-generation WSS platform, the Xnode. In addition to meeting the acceleration sensing demands of large-scale civil infrastructure applications, this new WSS node provides powerful hardware and a robust software framework to enable edge computing that can deliver actionable information. Hardware and software integration challenges are presented, and the associate resolutions are discussed. The performance of the wireless accelerometer is demonstrated experimentally through comparison with high-sensitivity wired accelerometers. This new high-sensitivity wireless accelerometer will extend the use of WSSN to a broader class of SHM applications.

  9. An Experimental Study of the Low-cost MEMS-type Seismometer for Structural Health Monitoring

    NASA Astrophysics Data System (ADS)

    Yin, RenCheng; Wu, Yih-Min; Hsu, Ting-Yu

    2016-04-01

    The Earthquake Early Warning (EEW) research group at National Taiwan University (NTU) and a technology company have been developing a Micro Electro Mechanical Systems (MEMS) type of accelerometer named Palert designed for EEW purpose. The main advantage of Palert is that it is a relatively low-cost seismometer. On the other hand, due to the high price of commercial hardware of Structural Health Monitoring (SHM) systems, the application of SHM to buildings is limited. Therefore, the low price of Palert devices makes it affordable to general purpose application and would lead to popularization of SHM for buildings. This study serves as a pre-study for this purpose and the feasibility for SHM application for Palert is also verified. In order to monitor the health of the building, the method proposed by Nakata et al. is used to estimate fundamental normal-mode frequency of a steel building in the laboratory of the National Center for Research on Earthquake Engineering (NCREE). The results show that the Palert is reliable to measure the building's response for the most of the normal buildings with less than ten stories. The fundamental normal-mode frequencies estimated using the Palert are quite comparable to the ones estimated using the high-performance accelerometers and data acquisition system. The Palert illustrates the possibility to be used to monitor the health of a building but further studies are still necessary.

  10. Stabilised DNA secondary structures with increasing transcription localise hypermutable bases for somatic hypermutation in IGHV3-23.

    PubMed

    Duvvuri, Bhargavi; Duvvuri, Venkata R; Wu, Jianhong; Wu, Gillian E

    2012-07-01

    Somatic hypermutation (SHM) mediated by activation-induced cytidine deaminase (AID) is a transcription-coupled mechanism most responsible for generating high affinity antibodies. An issue remaining enigmatic in SHM is how AID is preferentially targeted during transcription to hypermutable bases in its substrates (WRC motifs) on both DNA strands. AID targets only single stranded DNA. By modelling the dynamical behaviour of IGHV3-23 DNA, a commonly used human variable gene segment, we observed that hypermutable bases on the non-transcribed strand are paired whereas those on transcribed strand are mostly unpaired. Hypermutable bases (both paired and unpaired) are made accessible to AID in stabilised secondary structures formed with increasing transcription levels. This observation provides a rationale for the hypermutable bases on both the strands of DNA being targeted to a similar extent despite having differences in unpairedness. We propose that increasing transcription and RNAP II stalling resulting in the formation and stabilisation of stem-loop structures with AID hotspots in negatively supercoiled region can localise the hypermutable bases of both strands of DNA, to AID-mediated SHM.

  11. Real-time condition assessment of RAPTOR telescope systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stull, Chris; Taylor, Stuart; Wren, James

    2010-11-30

    The RAPid Telescopes for Optical Response (RAPTOR) observatory network consists of several robotic astronomical telescopes primarily designed to search for astrophysical transients called a gamma-ray bursts (GRBs). Although intrinsically bright, GRBs are difficult to detect because of their short duration. Typically, they are first observed by satellites that then relay the coordinates of the GRB to a ground station which, in turn, distributes the coordinates over the internet so that ground based observers can perform follow-up observations. Typically the ground based observations begin after the GRB has ended and only residual emiSSion (the 'afterglow') is left. However, if the satellitemore » relays the GRB coordinates quickly enough, a 'fast' robotic telescope on the ground may be able to catch the GRB in progress. The RAPTOR telescope system is one of only a few in the world to have accomplished this feat. In order to achieve these results, the RAPTOR telescopes must operate autonomously at a high duty-cycle and in peak operating condition. Currently the telescopes are maintained in an ad hoc manner, often in a run-to-failure mode. The RAPTOR project could benefit greatly from a structural health monitoring (SHM) system, especially as more complex units are added to the suite of telescopes. This paper will summarize preliminary results from an SHM study performed on one of the RAPTOR telescopes. Damage scenarios that are of concern and that have been previously observed are first summarized. Then a specific study of damage to the telescope drive mechanism is presented where the data acquisition system is first described. Next, damage detection algorithms are developed with LANL's new publically available software SHMTools and the results of this process are discussed in detail. The paper will conclude with a summary of future planned refinemenls of the RAPTOR SHM system.« less

  12. Evaluation of peak-free electromechanical piezo-impedance and electromagnetic contact sensing using metamaterial surface plasmons for load monitoring

    NASA Astrophysics Data System (ADS)

    Gopal Madhav Annamdas, Venu; Kiong Soh, Chee

    2017-01-01

    Continuous structural health monitoring (SHM) and delayed SHM techniques can be contact/ contactless, surface bonded/embedded, wired/wireless and active/passive actuator-sensor systems which transfer the recorded condition of the structure to the base station almost instantaneously or with time delay respectively. The time between fatal crack initiation and its propagation leading to the collapse of key infrastructures such as aerospace, nuclear facilities, oil and gas is mostly short. Timely discovery of structural problem depends heavily on the scanning period in well-established techniques like piezoelectric (PZT) based electromechanical impedance (EMI) technique. This often takes much scanning time due to the acquisition of resonant structural peaks at all frequencies in the considered bandwidth; thus poses a challenge for its implementation in practice. On the other hand, recently developed strain sensors based on metamaterials and their breeds such as nested split-ring resonators, localized surface plasmons (LSP), etc, employ measurement of reflected or transmitted signal, with super-fast scanning in the order of at most 1/100th of the time taken by the EMI technique. This paper articulates faster measurements by reducing unnecessary resonant structural peaks and focusing on rapid monitoring using PZT and metamaterial plasmons. Our research adopted wired PZT and wireless LSP communications with impedance analyser and vector network analyser respectively. We present integrated and complementary nature of these techniques, which can be processed rapidly for key infrastructures with great effectiveness. This integration can result in both continuous and delayed SHM techniques based on time or frequency or both domains.

  13. Design of external sensors board based on Bluetooth interface of smart phones for structural health monitoring system

    NASA Astrophysics Data System (ADS)

    Yu, Yan; Zhou, Yaping; Zhao, Xuefeng; Li, Dongsheng; Ou, Jinping

    2016-04-01

    As an important part of new information technology, the Internet of Things(IoT) is based on intelligent perception, recognition technology, ubiquitous computing, ubiquitous network integration, and it is known as the third wave of the development of information industry in the world after the computer and the Internet. And Smart Phones are the general term for a class of mobile phones with a separate operating system and operational memory, in which the third-party service programs including software, games, navigation, et.al, can be installed. Smart Phones, with not only sensors but also actuators, are widely used in the IoT world. As the current hot issues in the engineering area, Structural health monitoring (SHM) is also facing new problems about design ideas in the IoT environment. The development of IoT, wireless sensor network and mobile communication technology, provides a good technical platform for SHM. Based on these facts, this paper introduces a kind of new idea for Structural Health Monitoring using Smart Phones Technique. The system is described in detail, and the external sensor board based on Bluetooth interface is designed, the test based on Smart Phones is finished to validate the implementation and feasibility. The research is preliminary and more tests need to be carried out before it can be of practical use.

  14. Hybrid motion sensing and experimental modal analysis using collocated smartphone camera and accelerometers

    NASA Astrophysics Data System (ADS)

    Ozer, Ekin; Feng, Dongming; Feng, Maria Q.

    2017-10-01

    State-of-the-art multisensory technologies and heterogeneous sensor networks propose a wide range of response measurement opportunities for structural health monitoring (SHM). Measuring and fusing different physical quantities in terms of structural vibrations can provide alternative acquisition methods and improve the quality of the modal testing results. In this study, a recently introduced SHM concept, SHM with smartphones, is focused to utilize multisensory smartphone features for a hybridized structural vibration response measurement framework. Based on vibration testing of a small-scale multistory laboratory model, displacement and acceleration responses are monitored using two different smartphone sensors, an embedded camera and accelerometer, respectively. Double-integration or differentiation among different measurement types is performed to combine multisensory measurements on a comparative basis. In addition, distributed sensor signals from collocated devices are processed for modal identification, and performance of smartphone-based sensing platforms are tested under different configuration scenarios and heterogeneity levels. The results of these tests show a novel and successful implementation of a hybrid motion sensing platform through multiple sensor type and device integration. Despite the heterogeneity of motion data obtained from different smartphone devices and technologies, it is shown that multisensory response measurements can be blended for experimental modal analysis. Getting benefit from the accessibility of smartphone technology, similar smartphone-based dynamic testing methodologies can provide innovative SHM solutions with mobile, programmable, and cost-free interfaces.

  15. Printing of microstructure strain sensor for structural health monitoring

    NASA Astrophysics Data System (ADS)

    Le, Minh Quyen; Ganet, Florent; Audigier, David; Capsal, Jean-Fabien; Cottinet, Pierre-Jean

    2017-05-01

    Recent advances in microelectronics and materials should allow the development of integrated sensors with transduction properties compatible with being printed directly onto a 3D substrate, especially metallic and polymer substrates. Inorganic and organic electronic materials in microstructured and nanostructured forms, intimately integrated in ink, offer particularly attractive characteristics, with realistic pathways to sophisticated embodiments. Here, we report on these strategies and demonstrate the potential of 3D-printed microelectronics based on a structural health monitoring (SHM) application for the precision weapon systems. We show that our printed sensors can be employed in non-invasive, high-fidelity and continuous strain monitoring of handguns, making it possible to implement printed sensors on a 3D substrate in either SHM or remote diagnostics. We propose routes to commercialization and novel device opportunities and highlight the remaining challenges for research.

  16. Wind turbine blade fatigue tests: lessons learned and application to SHM system development

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Taylor, Stuart G.; Farinholt, Kevin M.; Jeong, Hyomi

    2012-06-28

    This paper presents experimental results of several structural health monitoring (SHM) methods applied to a 9-meter CX-100 wind turbine blade that underwent fatigue loading. The blade was instrumented with piezoelectric transducers, accelerometers, acoustic emission sensors, and foil strain gauges. It underwent harmonic excitation at its first natural frequency using a hydraulically actuated resonant excitation system. The blade was initially excited at 25% of its design load, and then with steadily increasing loads until it failed. Various data were collected between and during fatigue loading sessions. The data were measured over multiple frequency ranges using a variety of acquisition equipment, includingmore » off-the-shelf systems and specially designed hardware developed by the authors. Modal response, diffuse wave-field transfer functions, and ultrasonic guided wave methods were applied to assess the condition of the wind turbine blade. The piezoelectric sensors themselves were also monitored using a sensor diagnostics procedure. This paper summarizes experimental procedures and results, focusing particularly on fatigue crack detection, and concludes with considerations for implementing such damage identification systems, which will be used as a guideline for future SHM system development for operating wind turbine blades.« less

  17. An Experimental Study on Static and Dynamic Strain Sensitivity of Embeddable Smart Concrete Sensors Doped with Carbon Nanotubes for SHM of Large Structures.

    PubMed

    Meoni, Andrea; D'Alessandro, Antonella; Downey, Austin; García-Macías, Enrique; Rallini, Marco; Materazzi, A Luigi; Torre, Luigi; Laflamme, Simon; Castro-Triguero, Rafael; Ubertini, Filippo

    2018-03-09

    The availability of new self-sensing cement-based strain sensors allows the development of dense sensor networks for Structural Health Monitoring (SHM) of reinforced concrete structures. These sensors are fabricated by doping cement-matrix mterials with conductive fillers, such as Multi Walled Carbon Nanotubes (MWCNTs), and can be embedded into structural elements made of reinforced concrete prior to casting. The strain sensing principle is based on the multifunctional composites outputting a measurable change in their electrical properties when subjected to a deformation. Previous work by the authors was devoted to material fabrication, modeling and applications in SHM. In this paper, we investigate the behavior of several sensors fabricated with and without aggregates and with different MWCNT contents. The strain sensitivity of the sensors, in terms of fractional change in electrical resistivity for unit strain, as well as their linearity are investigated through experimental testing under both quasi-static and sine-sweep dynamic uni-axial compressive loadings. Moreover, the responses of the sensors when subjected to destructive compressive tests are evaluated. Overall, the presented results contribute to improving the scientific knowledge on the behavior of smart concrete sensors and to furthering their understanding for SHM applications.

  18. An Experimental Study on Static and Dynamic Strain Sensitivity of Embeddable Smart Concrete Sensors Doped with Carbon Nanotubes for SHM of Large Structures

    PubMed Central

    Meoni, Andrea; D’Alessandro, Antonella; García-Macías, Enrique; Rallini, Marco; Materazzi, A. Luigi; Torre, Luigi; Laflamme, Simon; Castro-Triguero, Rafael

    2018-01-01

    The availability of new self-sensing cement-based strain sensors allows the development of dense sensor networks for Structural Health Monitoring (SHM) of reinforced concrete structures. These sensors are fabricated by doping cement-matrix mterials with conductive fillers, such as Multi Walled Carbon Nanotubes (MWCNTs), and can be embedded into structural elements made of reinforced concrete prior to casting. The strain sensing principle is based on the multifunctional composites outputting a measurable change in their electrical properties when subjected to a deformation. Previous work by the authors was devoted to material fabrication, modeling and applications in SHM. In this paper, we investigate the behavior of several sensors fabricated with and without aggregates and with different MWCNT contents. The strain sensitivity of the sensors, in terms of fractional change in electrical resistivity for unit strain, as well as their linearity are investigated through experimental testing under both quasi-static and sine-sweep dynamic uni-axial compressive loadings. Moreover, the responses of the sensors when subjected to destructive compressive tests are evaluated. Overall, the presented results contribute to improving the scientific knowledge on the behavior of smart concrete sensors and to furthering their understanding for SHM applications. PMID:29522498

  19. A vibro-haptic human-machine interface for structural health monitoring

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mascarenas, David; Plont, Crystal; Brown, Christina

    The structural health monitoring (SHM) community’s goal has been to endow physical systems with a nervous system not unlike those commonly found in living organisms. Typically the SHM community has attempted to do this by instrumenting structures with a variety of sensors, and then applying various signal processing and classification procedures to the data in order to detect the presence of damage, the location of damage, the severity of damage, and to estimate the remaining useful life of the structure. This procedure has had some success, but we are still a long way from achieving the performance of nervous systemsmore » found in biology. This is primarily because contemporary classification algorithms do not have the performance required. In many cases expert judgment is superior to automated classification. This work introduces a new paradigm. We propose interfacing the human nervous system to the distributed sensor network located on the structure and developing new techniques to enable human-machine cooperation. Results from the field of sensory substitution suggest this should be possible. This study investigates a vibro-haptic human-machine interface for SHM. The investigation was performed using a surrogate three-story structure. The structure features three nonlinearity-inducing bumpers to simulate damage. Accelerometers are placed on each floor to measure the response of the structure to a harmonic base excitation. The accelerometer measurements are preprocessed. As a result, the preprocessed data is then encoded encoded as a vibro-tactile stimulus. Human subjects were then subjected to the vibro-tactile stimulus and asked to characterize the damage in the structure.« less

  20. A vibro-haptic human-machine interface for structural health monitoring

    DOE PAGES

    Mascarenas, David; Plont, Crystal; Brown, Christina; ...

    2014-11-01

    The structural health monitoring (SHM) community’s goal has been to endow physical systems with a nervous system not unlike those commonly found in living organisms. Typically the SHM community has attempted to do this by instrumenting structures with a variety of sensors, and then applying various signal processing and classification procedures to the data in order to detect the presence of damage, the location of damage, the severity of damage, and to estimate the remaining useful life of the structure. This procedure has had some success, but we are still a long way from achieving the performance of nervous systemsmore » found in biology. This is primarily because contemporary classification algorithms do not have the performance required. In many cases expert judgment is superior to automated classification. This work introduces a new paradigm. We propose interfacing the human nervous system to the distributed sensor network located on the structure and developing new techniques to enable human-machine cooperation. Results from the field of sensory substitution suggest this should be possible. This study investigates a vibro-haptic human-machine interface for SHM. The investigation was performed using a surrogate three-story structure. The structure features three nonlinearity-inducing bumpers to simulate damage. Accelerometers are placed on each floor to measure the response of the structure to a harmonic base excitation. The accelerometer measurements are preprocessed. As a result, the preprocessed data is then encoded encoded as a vibro-tactile stimulus. Human subjects were then subjected to the vibro-tactile stimulus and asked to characterize the damage in the structure.« less

  1. Simulation tools for guided wave based structural health monitoring

    NASA Astrophysics Data System (ADS)

    Mesnil, Olivier; Imperiale, Alexandre; Demaldent, Edouard; Baronian, Vahan; Chapuis, Bastien

    2018-04-01

    Structural Health Monitoring (SHM) is a thematic derived from Non Destructive Evaluation (NDE) based on the integration of sensors onto or into a structure in order to monitor its health without disturbing its regular operating cycle. Guided wave based SHM relies on the propagation of guided waves in plate-like or extruded structures. Using piezoelectric transducers to generate and receive guided waves is one of the most widely accepted paradigms due to the low cost and low weight of those sensors. A wide range of techniques for flaw detection based on the aforementioned setup is available in the literature but very few of these techniques have found industrial applications yet. A major difficulty comes from the sensitivity of guided waves to a substantial number of parameters such as the temperature or geometrical singularities, making guided wave measurement difficult to analyze. In order to apply guided wave based SHM techniques to a wider spectrum of applications and to transfer those techniques to the industry, the CEA LIST develops novel numerical methods. These methods facilitate the evaluation of the robustness of SHM techniques for multiple applicative cases and ease the analysis of the influence of various parameters, such as sensors positioning or environmental conditions. The first numerical tool is the guided wave module integrated to the commercial software CIVA, relying on a hybrid modal-finite element formulation to compute the guided wave response of perturbations (cavities, flaws…) in extruded structures of arbitrary cross section such as rails or pipes. The second numerical tool is based on the spectral element method [2] and simulates guided waves in both isotropic (metals) and orthotropic (composites) plate like-structures. This tool is designed to match the widely accepted sparse piezoelectric transducer array SHM configuration in which each embedded sensor acts as both emitter and receiver of guided waves. This tool is under development and will be adapted to simulate complex real-life structures such as curved composite panels with stiffeners. This communication will present these numerical tools and their main functionalities.

  2. Evaluating Post-Earthquake Building Safety Using Economical MEMS Seismometers

    PubMed Central

    Yin, Ren-Cheng

    2018-01-01

    The earthquake early warning (EEW)-research group at National Taiwan University has been developing a microelectromechanical system-based accelerometer called “P-Alert”, designed for issuing EEWs. The main advantage of P-Alert is that it is a relatively economical seismometer. However, because of the expensive nature of commercial hardware for structural health monitoring (SHM) systems, the application of SHM to buildings remains limited. To determine the performance of P-Alert for evaluating post-earthquake building safety, we conducted a series of steel-frame shaking table tests with incremental damage. We used the fragility curves of different damage levels and the interstory drift ratios (calculated by the measured acceleration of each story using double integration and a filter) to gauge the potential damage levels. We concluded that the acceptable detection of damage for an entire building is possible. With improvements to the synchronization of the P-Alert sensors, we also anticipate a damage localization feature for the stories of a building. PMID:29734736

  3. Structural Health Monitoring with Fiber Bragg Grating and Piezo Arrays

    NASA Technical Reports Server (NTRS)

    Black, Richard J.; Faridian, Ferey; Moslehi, Behzad; Sotoudeh, Vahid

    2012-01-01

    Structural health monitoring (SHM) is one of the most important tools available for the maintenance, safety, and integrity of aerospace structural systems. Lightweight, electromagnetic-interference- immune, fiber-optic sensor-based SHM will play an increasing role in more secure air transportation systems. Manufacturers and maintenance personnel have pressing needs for significantly improving safety and reliability while providing for lower inspection and maintenance costs. Undetected or untreated damage may grow and lead to catastrophic structural failure. Damage can originate from the strain/stress history of the material, imperfections of domain boundaries in metals, delamination in multi-layer materials, or the impact of machine tools in the manufacturing process. Damage can likewise develop during service life from wear and tear, or under extraordinary circumstances such as with unusual forces, temperature cycling, or impact of flying objects. Monitoring and early detection are key to preventing a catastrophic failure of structures, especially when these are expected to perform near their limit conditions.

  4. Evaluating Post-Earthquake Building Safety Using Economical MEMS Seismometers.

    PubMed

    Hsu, Ting-Yu; Yin, Ren-Cheng; Wu, Yih-Min

    2018-05-05

    The earthquake early warning (EEW)-research group at National Taiwan University has been developing a microelectromechanical system-based accelerometer called “P-Alert”, designed for issuing EEWs. The main advantage of P-Alert is that it is a relatively economical seismometer. However, because of the expensive nature of commercial hardware for structural health monitoring (SHM) systems, the application of SHM to buildings remains limited. To determine the performance of P-Alert for evaluating post-earthquake building safety, we conducted a series of steel-frame shaking table tests with incremental damage. We used the fragility curves of different damage levels and the interstory drift ratios (calculated by the measured acceleration of each story using double integration and a filter) to gauge the potential damage levels. We concluded that the acceptable detection of damage for an entire building is possible. With improvements to the synchronization of the P-Alert sensors, we also anticipate a damage localization feature for the stories of a building.

  5. Identification of unusual events in multi-channel bridge monitoring data

    NASA Astrophysics Data System (ADS)

    Omenzetter, Piotr; Brownjohn, James Mark William; Moyo, Pilate

    2004-03-01

    Continuously operating instrumented structural health monitoring (SHM) systems are becoming a practical alternative to replace visual inspection for assessment of condition and soundness of civil infrastructure such as bridges. However, converting large amounts of data from an SHM system into usable information is a great challenge to which special signal processing techniques must be applied. This study is devoted to identification of abrupt, anomalous and potentially onerous events in the time histories of static, hourly sampled strains recorded by a multi-sensor SHM system installed in a major bridge structure and operating continuously for a long time. Such events may result, among other causes, from sudden settlement of foundation, ground movement, excessive traffic load or failure of post-tensioning cables. A method of outlier detection in multivariate data has been applied to the problem of finding and localising sudden events in the strain data. For sharp discrimination of abrupt strain changes from slowly varying ones wavelet transform has been used. The proposed method has been successfully tested using known events recorded during construction of the bridge, and later effectively used for detection of anomalous post-construction events.

  6. Review on energy harvesting for structural health monitoring in aeronautical applications

    NASA Astrophysics Data System (ADS)

    Le, Minh Quyen; Capsal, Jean-Fabien; Lallart, Mickaël; Hebrard, Yoann; Van Der Ham, Andre; Reffe, Nicolas; Geynet, Lionel; Cottinet, Pierre-Jean

    2015-11-01

    This paper reviews recent developments in energy harvesting technologies for structural health monitoring (SHM) in aeronautical applications. Aeronautical industries show a great deal of interest in obtaining technologies that can be used to monitor the health of machinery and structures. In particular, the need for self-sufficient monitoring of structures has been ever-increasing in recent years. Autonomous SHM systems typically include embedded sensors, and elements for data acquisition, wireless communication, and energy harvesting. Among all of these components, this paper focuses on energy harvesting technologies. Actually, low-power sensors and wireless communication components are used in newer SHM systems, and a number of researchers have recently investigated such techniques to extract energy from the local environment to power these stand-alone systems. The first part of the paper is dedicated to the different energy sources available in aeronautical applications, i.e., for airplanes and helicopters. The second part gives a presentation of the various devices developed for converting ambient energy into electric power. The last part is dedicated to a comparison of the different technologies and the future development of energy harvesting for aeronautical applications.

  7. Development of an embedded thin-film strain-gauge-based SHM network into 3D-woven composite structure for wind turbine blades

    NASA Astrophysics Data System (ADS)

    Zhao, Dongning; Rasool, Shafqat; Forde, Micheal; Weafer, Bryan; Archer, Edward; McIlhagger, Alistair; McLaughlin, James

    2017-04-01

    Recently, there has been increasing demand in developing low-cost, effective structure health monitoring system to be embedded into 3D-woven composite wind turbine blades to determine structural integrity and presence of defects. With measuring the strain and temperature inside composites at both in-situ blade resin curing and in-service stages, we are developing a novel scheme to embed a resistive-strain-based thin-metal-film sensory into the blade spar-cap that is made of composite laminates to determine structural integrity and presence of defects. Thus, with fiberglass, epoxy, and a thinmetal- film sensing element, a three-part, low-cost, smart composite laminate is developed. Embedded strain sensory inside composite laminate prototype survived after laminate curing process. The internal strain reading from embedded strain sensor under three-point-bending test standard is comparable. It proves that our proposed method will provide another SHM alternative to reduce sensing costs during the renewable green energy generation.

  8. Development of a Wireless Unified-Maintenance System for the Structural Health Monitoring of Civil Structures

    PubMed Central

    Son, Byungjik; Jeon, Seunggon

    2018-01-01

    A disaster preventive structural health monitoring (SHM) system needs to be equipped with the following abilities: First, it should be able to simultaneously measure diverse types of data (e.g., displacement, velocity, acceleration, strain, load, temperature, humidity, etc.) for accurate diagnosis. Second, it also requires standalone power supply to guarantee its immediate response in crisis (e.g., sudden interruption of normal AC power in disaster situations). Furthermore, it should be capable of prompt processing and realtime wireless communication of a huge amount of data. Therefore, this study is aimed at developing a wireless unified-maintenance system (WUMS) that would satisfy all the requirements for a disaster preventive SHM system of civil structures. The WUMS is designed to measure diverse types of structural responses in realtime based on wireless communication, allowing users to selectively use WiFi RF band and finally working in standalone mode by means of the field-programmable gate array (FPGA) technology. To verify its performance, the following tests were performed: (i) A test to see how far communication is possible in open field, (ii) a test on a shaker to see how accurate responses are, (iii) a modal test on a bridge to see how exactly characteristic real-time dynamic responses are of structures. The test results proved that the WUMS was able to secure stable communication far up to nearly 800 m away by acquiring wireless responses in realtime accurately, when compared to the displacement and acceleration responses which were acquired through wired communication. The analysis of dynamic characteristics also showed that the wireless acceleration responses in real-time represented satisfactorily the dynamic properties of structures. Therefore, the WUMS is proved valid as a SHM, and its outstanding performance is also proven. PMID:29747403

  9. Development of a Wireless Unified-Maintenance System for the Structural Health Monitoring of Civil Structures.

    PubMed

    Heo, Gwanghee; Son, Byungjik; Kim, Chunggil; Jeon, Seunggon; Jeon, Joonryong

    2018-05-09

    A disaster preventive structural health monitoring (SHM) system needs to be equipped with the following abilities: First, it should be able to simultaneously measure diverse types of data (e.g., displacement, velocity, acceleration, strain, load, temperature, humidity, etc.) for accurate diagnosis. Second, it also requires standalone power supply to guarantee its immediate response in crisis (e.g., sudden interruption of normal AC power in disaster situations). Furthermore, it should be capable of prompt processing and realtime wireless communication of a huge amount of data. Therefore, this study is aimed at developing a wireless unified-maintenance system (WUMS) that would satisfy all the requirements for a disaster preventive SHM system of civil structures. The WUMS is designed to measure diverse types of structural responses in realtime based on wireless communication, allowing users to selectively use WiFi RF band and finally working in standalone mode by means of the field-programmable gate array (FPGA) technology. To verify its performance, the following tests were performed: (i) A test to see how far communication is possible in open field, (ii) a test on a shaker to see how accurate responses are, (iii) a modal test on a bridge to see how exactly characteristic real-time dynamic responses are of structures. The test results proved that the WUMS was able to secure stable communication far up to nearly 800 m away by acquiring wireless responses in realtime accurately, when compared to the displacement and acceleration responses which were acquired through wired communication. The analysis of dynamic characteristics also showed that the wireless acceleration responses in real-time represented satisfactorily the dynamic properties of structures. Therefore, the WUMS is proved valid as a SHM, and its outstanding performance is also proven.

  10. A variable-frequency bidirectional shear horizontal (SH) wave transducer based on dual face-shear (d24) piezoelectric wafers.

    PubMed

    Miao, Hongchen; Huan, Qiang; Li, Faxin; Kang, Guozheng

    2018-04-24

    Focusing the incident wave beam along a given direction is very useful in guided wave based structural health monitoring (SHM), as it will not only save input power but also simplify the interpretation of signals. Although the fundamental shear horizontal (SH 0 ) wave is of practical importance in SHM due to its non-dispersive characteristics so far there have been very limited transducers which can control the radiation patterns of SH 0 wave. In this work, a variable-frequency bidirectional SH 0 wave piezoelectric transducer (BSH-PT) is proposed, which consists of two rectangular face-shear (d 24 ) PZT wafers. The opposite face-shear deformation of the two PZT wafers under applied electric fields makes the BSH-PT capable of exciting SH 0 wave along two opposite directions (0° and 180°). Both finite element simulations and experimental testings are conducted to examine the performance of the proposed BSH-PT. Results show that pure SH 0 wave can be generated by this BSH-PT and its wave beam can be focused bi-directionally. Moreover, the bidirectional characteristics of the BSH-PT can be kept over a wide frequency range from 150 kHz to 250 kHz. As the circumferential SH 0 (CSH 0 ) wave in a thin hollow cylindrical structure is essentially equivalent to the SH 0 wave in a plate, the proposed BSH-PT may also be very useful to develop a CSH 0 -wave-based SHM system for hollow cylindrical structures. Copyright © 2018 Elsevier B.V. All rights reserved.

  11. New strategies for SHM based on a multichannel wireless AE node

    NASA Astrophysics Data System (ADS)

    Godinez-Azcuaga, Valery; Ley, Obdulia

    2014-03-01

    This paper discusses the development of an Acoustic Emission (AE) wireless node and its application for SHM (Structural Health Monitoring). The instrument development was planned for applications monitoring steel and concrete bridges components. The final product, now commercially available, is a sensor node which includes multiple sensing elements, on board signal processing and analysis capabilities, signal conditioning electronics, power management circuits, wireless data transmission element and energy harvesting unit. The sensing elements are capable of functioning in both passive and active modes, while the multiple parametric inputs are available for connecting various sensor types to measure external characteristics affecting the performance of the structure under monitoring. The output of all these sensors are combined and analyzed at the node in order to minimize the data transmission rate, which consumes significant amount of power. Power management circuits are used to reduce the data collection intervals through selective data acquisition strategies and minimize the sensor node power consumption. This instrument, known as the 1284, is an excellent platform to deploy SHM in the original bridge applications, but initial prototypes has shown significant potential in monitoring composite wind turbine blades and composites mockups of Unmanned Autonomous Vehicles (UAV) components; currently we are working to extend the use of this system to fields such as coal flow, power transformer, and off-shore platform monitoring.

  12. Strength and fatigue life evaluation of composite laminate with embedded sensors

    NASA Astrophysics Data System (ADS)

    Rathod, Vivek T.; Hiremath, S. R.; Roy Mahapatra, D.

    2014-04-01

    Prognosis regarding durability of composite structures using various Structural Health Monitoring (SHM) techniques is an important and challenging topic of research. Ultrasonic SHM systems with embedded transducers have potential application here due to their instant monitoring capability, compact packaging potential toward unobtrusiveness and noninvasiveness as compared to non-contact ultrasonic and eddy current techniques which require disassembly of the structure. However, embedded sensors pose a risk to the structure by acting as a flaw thereby reducing life. The present paper focuses on the determination of strength and fatigue life of the composite laminate with embedded film sensors like CNT nanocomposite, PVDF thin films and piezoceramic films. First, the techniques of embedding these sensors in composite laminates is described followed by the determination of static strength and fatigue life at coupon level testing in Universal Testing Machine (UTM). Failure mechanisms of the composite laminate with embedded sensors are studied for static and dynamic loading cases. The coupons are monitored for loading and failure using the embedded sensors. A comparison of the performance of these three types of embedded sensors is made to study their suitability in various applications. These three types of embedded sensors cover a wide variety of applications, and prove to be viable in embedded sensor based SHM of composite structures.

  13. Impact of Society of Hospital Medicine workshops on hospitalists' knowledge and perceptions of health care-associated infections and antimicrobial resistance.

    PubMed

    Bush-Knapp, Megan E; Budnitz, Tina; Lawton-Ciccarone, Rachel M; Sinkowitz-Cochran, Ronda L; Brinsley-Rainisch, Kristin J; Dressler, Daniel D; Williams, Mark V

    2007-07-01

    Health care-associated infections and antimicrobial resistance threaten the safety of hospitalized patients. New prevention strategies are necessary to address these problems. In response, the Society of Hospital Medicine (SHM) in collaboration with the Centers for Disease Control and Prevention developed and conducted workshops to educate hospitalists about conducting quality improvement programs to address antimicrobial resistance and health care-associated infections in hospitalized patients. SHM collected and analyzed data from pretests and posttests administered to physicians who attended SHM workshops in 2005 in 1 of 3 major cities: Denver, Colorado; Boston, Massachusetts; or Portland, Oregon. A total of 69 SHM members attended the workshops, and 50 completed both a pretest and a posttest. Scores on the knowledge-based questions increased significantly from pretest to posttest (x = 48% vs. 63%, P < .0001); however, perceptions of the problem of antimicrobial resistance did not change. Most participants (85%) rated the quality of the workshop as "very good" or "excellent" and rated the workshop sessions as "useful" (x = 3.9 on a 5.0 scale). Hospitalists who attended the SHM workshop increased their knowledge of health care-associated infections, antimicrobial resistance, and quality improvement programs related to these issues. Similar workshops should be considered in efforts to prevent health care-associated infections and antimicrobial resistance. (c) 2007 Society of Hospital Medicine.

  14. Knight Hawk adapts highwall mining for Southern Illinois

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Buchsbaum, L.

    2007-10-15

    A few years ago while planning their first underground operation and trying to decide how to mine shallow seams, Knight Hawk purchased a 'Superior Highwall Miner' (SHM). Since then this small innovative company has been pioneering the use of highwall mining in a trenching application in for example the Illinois Basin. Highwall mining is very suitable for contour mining in Appalachia. The article discusses the recent improvements and the advantages of SHM mining systems. 3 photos.

  15. Opportunities and challenges for structural health monitoring of radioactive waste systems and structures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Giurgiutiu, Victor; Mendez Torres, Adrian E.

    2013-07-01

    Radioactive waste systems and structures (RWSS) are safety-critical facilities in need of monitoring over prolonged periods of time. Structural health monitoring (SHM) is an emerging technology that aims at monitoring the state of a structure through the use of networks of permanently mounted sensors. SHM technologies have been developed primarily within the aerospace and civil engineering communities. This paper addresses the issue of transitioning the SHM concept to the monitoring of RWSS and evaluates the opportunities and challenges associated with this process. Guided wave SHM technologies utilizing structurally-mounted piezoelectric wafer active sensors (PWAS) have a wide range of applications basedmore » on both propagating-wave and standing-wave methodologies. Hence, opportunities exist for transitioning these SHM technologies into RWSS monitoring. However, there exist certain special operational conditions specific to RWSS such as: radiation field, caustic environments, marine environments, and chemical, mechanical and thermal stressors. In order to address the high discharge of used nuclear fuel (UNF) and the limited space in the storage pools the U.S. the Department of Energy (DOE) has adopted a 'Strategy for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive Waste' (January 2013). This strategy endorses the key principles that underpin the Blue Ribbon Commission's on America's Nuclear Future recommendations to develop a sustainable program for deploying an integrated system capable of transporting, storing, and disposing of UNF and high-level radioactive waste from civilian nuclear power generation, defense, national security, and other activities. This will require research to develop monitoring, diagnosis, and prognosis tools that can aid to establish a strong technical basis for extended storage and transportation of UNF. Monitoring of such structures is critical for assuring the safety and security of the nation's spent nuclear fuel until a national policy for closure of the nuclear fuel cycle is defined and implemented. In addition, such tools can provide invaluable and timely information for verification of the predicted mechanical performance of RWSS (e.g. concrete or steel barriers) during off-normal occurrence and accident events such as the tsunami and earthquake event that affected Fukushima Daiichi nuclear power plant. The ability to verify the conditions, health, and degradation behavior of RWSS over time by applying nondestructive testing (NDT) as well as development of nondestructive evaluation (NDE) tools for new degradation processes will become challenging. The paper discusses some of the challenges associated to verification and diagnosis for RWSS and identifies SHM technologies which are more readily available for transitioning into RWSS applications. Fundamental research objectives that should be considered for the transition of SHM technologies (e.g., radiation hardened piezoelectric materials) for RWSS applications are discussed. The paper ends with summary, conclusions, and suggestions for further work. (authors)« less

  16. Numerical modeling of the load effect on PZT-induced guided wave for load compensation of damage detection

    NASA Astrophysics Data System (ADS)

    Sun, Hu; Zhang, Aijia; Wang, Yishou; Qing, Xinlin P.

    2017-04-01

    Guided wave-based structural health monitoring (SHM) has been given considerable attention and widely studied for large-scale aircraft structures. Nevertheless, it is difficult to apply SHM systems on board or online, for which one of the most serious reasons is the environmental influence. Load is one fact that affects not only the host structure, in which guided wave propagates, but also the PZT, by which guided wave is transmitted and received. In this paper, numerical analysis using finite element method is used to study the load effect on guided wave acquired by PZT. The static loads with different grades are considered to analyze its effect on guided wave signals that PZT transmits and receives. Based on the variation trend of guided waves versus load, a load compensation method is developed to eliminate effects of load in the process of damage detection. The probabilistic reconstruction algorithm based on the signal variation of transmitter-receiver path is employed to identify the damage. Numerical tests is conducted to verify the feasibility and effectiveness of the given method.

  17. Structural health monitoring (vibration) as a tool for identifying structural alterations of the lumbar spine: a twin control study.

    PubMed

    Kawchuk, Gregory N; Hartvigsen, Jan; Edgecombe, Tiffany; Prasad, Narasimha; van Dieen, Jaap H

    2016-03-11

    Structural health monitoring (SHM) is an engineering technique used to identify mechanical abnormalities not readily apparent through other means. Recently, SHM has been adapted for use in biological systems, but its invasive nature limits its clinical application. As such, the purpose of this project was to determine if a non-invasive form of SHM could identify structural alterations in the spines of living human subjects. Lumbar spines of 10 twin pairs were visualized by magnetic resonance imaging then assessed by a blinded radiologist to determine whether twin pairs were structurally concordant or discordant. Vibration was then applied to each subject's spine and the resulting response recorded from sensors overlying lumbar spinous processes. The peak frequency, area under the curve and the root mean square were computed from the frequency response function of each sensor. Statistical analysis demonstrated that in twins whose structural appearance was discordant, peak frequency was significantly different between twin pairs while in concordant twins, no outcomes were significantly different. From these results, we conclude that structural changes within the spine can alter its vibration response. As such, further investigation of SHM to identify spinal abnormalities in larger human populations is warranted.

  18. Real-time vibration-based structural damage detection using one-dimensional convolutional neural networks

    NASA Astrophysics Data System (ADS)

    Abdeljaber, Osama; Avci, Onur; Kiranyaz, Serkan; Gabbouj, Moncef; Inman, Daniel J.

    2017-02-01

    Structural health monitoring (SHM) and vibration-based structural damage detection have been a continuous interest for civil, mechanical and aerospace engineers over the decades. Early and meticulous damage detection has always been one of the principal objectives of SHM applications. The performance of a classical damage detection system predominantly depends on the choice of the features and the classifier. While the fixed and hand-crafted features may either be a sub-optimal choice for a particular structure or fail to achieve the same level of performance on another structure, they usually require a large computation power which may hinder their usage for real-time structural damage detection. This paper presents a novel, fast and accurate structural damage detection system using 1D Convolutional Neural Networks (CNNs) that has an inherent adaptive design to fuse both feature extraction and classification blocks into a single and compact learning body. The proposed method performs vibration-based damage detection and localization of the damage in real-time. The advantage of this approach is its ability to extract optimal damage-sensitive features automatically from the raw acceleration signals. Large-scale experiments conducted on a grandstand simulator revealed an outstanding performance and verified the computational efficiency of the proposed real-time damage detection method.

  19. Guided Lamb wave based 2-D spiral phased array for structural health monitoring of thin panel structures

    NASA Astrophysics Data System (ADS)

    Yoo, Byungseok

    2011-12-01

    In almost all industries of mechanical, aerospace, and civil engineering fields, structural health monitoring (SHM) technology is essentially required for providing the reliable information of structural integrity of safety-critical structures, which can help reduce the risk of unexpected and sometimes catastrophic failures, and also offer cost-effective inspection and maintenance of the structures. State of the art SHM research on structural damage diagnosis is focused on developing global and real-time technologies to identify the existence, location, extent, and type of damage. In order to detect and monitor the structural damage in plate-like structures, SHM technology based on guided Lamb wave (GLW) interrogation is becoming more attractive due to its potential benefits such as large inspection area coverage in short time, simple inspection mechanism, and sensitivity to small damage. However, the GLW method has a few critical issues such as dispersion nature, mode conversion and separation, and multiple-mode existence. Phased array technique widely used in all aspects of civil, military, science, and medical industry fields may be employed to resolve the drawbacks of the GLW method. The GLW-based phased array approach is able to effectively examine and analyze complicated structural vibration responses in thin plate structures. Because the phased sensor array operates as a spatial filter for the GLW signals, the array signal processing method can enhance a desired signal component at a specific direction while eliminating other signal components from other directions. This dissertation presents the development, the experimental validation, and the damage detection applications of an innovative signal processing algorithm based on two-dimensional (2-D) spiral phased array in conjunction with the GLW interrogation technique. It starts with general backgrounds of SHM and the associated technology including the GLW interrogation method. Then, it is focused on the fundamentals of the GLW-based phased array approach and the development of an innovative signal processing algorithm associated with the 2-D spiral phased sensor array. The SHM approach based on array responses determined by the proposed phased array algorithm implementation is addressed. The experimental validation of the GLW-based 2-D spiral phased array technology and the associated damage detection applications to thin isotropic plate and anisotropic composite plate structures are presented.

  20. Robust evaluation of time series classification algorithms for structural health monitoring

    NASA Astrophysics Data System (ADS)

    Harvey, Dustin Y.; Worden, Keith; Todd, Michael D.

    2014-03-01

    Structural health monitoring (SHM) systems provide real-time damage and performance information for civil, aerospace, and mechanical infrastructure through analysis of structural response measurements. The supervised learning methodology for data-driven SHM involves computation of low-dimensional, damage-sensitive features from raw measurement data that are then used in conjunction with machine learning algorithms to detect, classify, and quantify damage states. However, these systems often suffer from performance degradation in real-world applications due to varying operational and environmental conditions. Probabilistic approaches to robust SHM system design suffer from incomplete knowledge of all conditions a system will experience over its lifetime. Info-gap decision theory enables nonprobabilistic evaluation of the robustness of competing models and systems in a variety of decision making applications. Previous work employed info-gap models to handle feature uncertainty when selecting various components of a supervised learning system, namely features from a pre-selected family and classifiers. In this work, the info-gap framework is extended to robust feature design and classifier selection for general time series classification through an efficient, interval arithmetic implementation of an info-gap data model. Experimental results are presented for a damage type classification problem on a ball bearing in a rotating machine. The info-gap framework in conjunction with an evolutionary feature design system allows for fully automated design of a time series classifier to meet performance requirements under maximum allowable uncertainty.

  1. Structural health monitoring of wind turbine blades

    NASA Astrophysics Data System (ADS)

    Rumsey, Mark A.; Paquette, Joshua A.

    2008-03-01

    As electric utility wind turbines increase in size, and correspondingly, increase in initial capital investment cost, there is an increasing need to monitor the health of the structure. Acquiring an early indication of structural or mechanical problems allows operators to better plan for maintenance, possibly operate the machine in a de-rated condition rather than taking the unit off-line, or in the case of an emergency, shut the machine down to avoid further damage. This paper describes several promising structural health monitoring (SHM) techniques that were recently exercised during a fatigue test of a 9 meter glass-epoxy and carbon-epoxy wind turbine blade. The SHM systems were implemented by teams from NASA Kennedy Space Center, Purdue University and Virginia Tech. A commercial off-the-shelf acoustic emission (AE) NDT system gathered blade AE data throughout the test. At a fatigue load cycle rate around 1.2 Hertz, and after more than 4,000,000 fatigue cycles, the blade was diagnostically and visibly failing at the out-board blade spar-cap termination point at 4.5 meters. For safety reasons, the test was stopped just before the blade completely failed. This paper provides an overview of the SHM and NDT system setups and some current test results.

  2. Identification of unusual events in multichannel bridge monitoring data using wavelet transform and outlier analysis

    NASA Astrophysics Data System (ADS)

    Omenzetter, Piotr; Brownjohn, James M. W.; Moyo, Pilate

    2003-08-01

    Continuously operating instrumented structural health monitoring (SHM) systems are becoming a practical alternative to replace visual inspection for assessment of condition and soundness of civil infrastructure. However, converting large amount of data from an SHM system into usable information is a great challenge to which special signal processing techniques must be applied. This study is devoted to identification of abrupt, anomalous and potentially onerous events in the time histories of static, hourly sampled strains recorded by a multi-sensor SHM system installed in a major bridge structure in Singapore and operating continuously for a long time. Such events may result, among other causes, from sudden settlement of foundation, ground movement, excessive traffic load or failure of post-tensioning cables. A method of outlier detection in multivariate data has been applied to the problem of finding and localizing sudden events in the strain data. For sharp discrimination of abrupt strain changes from slowly varying ones wavelet transform has been used. The proposed method has been successfully tested using known events recorded during construction of the bridge, and later effectively used for detection of anomalous post-construction events.

  3. A Combination of Soybean and Haematococcus Extract Alleviates Ultraviolet B-Induced Photoaging

    PubMed Central

    Shin, Jieun; Kim, Jong-Eun; Pak, Kum-Ju; Kang, Jung Il; Kim, Tae-Seok; Lee, Sang-Yoon; Yeo, Ik-Hyun; Park, Jung Han Yoon; Kim, Jong Hun; Kang, Nam Joo; Lee, Ki Won

    2017-01-01

    Soybean-derived isoflavones have been investigated for their preventative effects against UV-induced symptoms of skin damage including wrinkle formation and inflammation. Haematococcus pluvialis is a freshwater species of Chlorophyta that contains high concentrations of the natural carotenoid pigment astaxanthin. Astaxanthin is known to be involved in retinoic acid receptor (RAR) signaling and previously been associated with the inhibition of activator protein (AP)-1 dependent transcription. Based on previous studies, we hypothesized that a combination of soy extract (SE) and Haematococcus extract (HE) may prevent UVB-induced photoaging through specific signaling pathways, as measured by UVB-induced wrinkling on hairless mice skin and expression changes in human dermal fibroblasts (HDFs). The 1:2 ratio of SE and HE mixture (SHM) showed the optimal benefit in vivo. SHM was found to inhibit wrinkle formation via the downregulation of matrix metalloproteinase (MMP)-1 mRNA and protein expression. SHM also inhibited mitogen-activated protein kinase (MAPK) phosphorylation and the transactivation of AP-1 which plays an important role in regulating MMP expression. These results highlight the potential for SHM to be developed as a therapeutic agent to prevent UVB-induced skin wrinkling. PMID:28327532

  4. A Combination of Soybean and Haematococcus Extract Alleviates Ultraviolet B-Induced Photoaging.

    PubMed

    Shin, Jieun; Kim, Jong-Eun; Pak, Kum-Ju; Kang, Jung Il; Kim, Tae-Seok; Lee, Sang-Yoon; Yeo, Ik-Hyun; Park, Jung Han Yoon; Kim, Jong Hun; Kang, Nam Joo; Lee, Ki Won

    2017-03-22

    Soybean-derived isoflavones have been investigated for their preventative effects against UV-induced symptoms of skin damage including wrinkle formation and inflammation. Haematococcus pluvialis is a freshwater species of Chlorophyta that contains high concentrations of the natural carotenoid pigment astaxanthin. Astaxanthin is known to be involved in retinoic acid receptor (RAR) signaling and previously been associated with the inhibition of activator protein (AP)-1 dependent transcription. Based on previous studies, we hypothesized that a combination of soy extract (SE) and Haematococcus extract (HE) may prevent UVB-induced photoaging through specific signaling pathways, as measured by UVB-induced wrinkling on hairless mice skin and expression changes in human dermal fibroblasts (HDFs). The 1:2 ratio of SE and HE mixture (SHM) showed the optimal benefit in vivo. SHM was found to inhibit wrinkle formation via the downregulation of matrix metalloproteinase (MMP)-1 mRNA and protein expression. SHM also inhibited mitogen-activated protein kinase (MAPK) phosphorylation and the transactivation of AP-1 which plays an important role in regulating MMP expression. These results highlight the potential for SHM to be developed as a therapeutic agent to prevent UVB-induced skin wrinkling.

  5. MSH6- or PMS2-deficiency causes re-replication in DT40 B cells, but it has little effect on immunoglobulin gene conversion or on repair of AID-generated uracils

    PubMed Central

    Campo, Vanina A.; Patenaude, Anne-Marie; Kaden, Svenja; Horb, Lori; Firka, Daniel; Jiricny, Josef; Di Noia, Javier M.

    2013-01-01

    The mammalian antibody repertoire is shaped by somatic hypermutation (SHM) and class switch recombination (CSR) of the immunoglobulin (Ig) loci of B lymphocytes. SHM and CSR are triggered by non-canonical, error-prone processing of G/U mismatches generated by activation-induced deaminase (AID). In birds, AID does not trigger SHM, but it triggers Ig gene conversion (GC), a ‘homeologous’ recombination process involving the Ig variable region and proximal pseudogenes. Because recombination fidelity is controlled by the mismatch repair (MMR) system, we investigated whether MMR affects GC in the chicken B cell line DT40. We show here that Msh6−/− and Pms2−/− DT40 cells display cell cycle defects, including genomic re-replication. However, although IgVλ GC tracts in MMR-deficient cells were slightly longer than in normal cells, Ig GC frequency, donor choice or the number of mutations per sequence remained unaltered. The finding that the avian MMR system, unlike that of mammals, does not seem to contribute towards the processing of G/U mismatches in vitro could explain why MMR is unable to initiate Ig GC in this species, despite initiating SHM and CSR in mammalian cells. Moreover, as MMR does not counteract or govern Ig GC, we report a rare example of ‘homeologous’ recombination insensitive to MMR. PMID:23314153

  6. Compressive sensing for efficient health monitoring and effective damage detection of structures

    NASA Astrophysics Data System (ADS)

    Jayawardhana, Madhuka; Zhu, Xinqun; Liyanapathirana, Ranjith; Gunawardana, Upul

    2017-02-01

    Real world Structural Health Monitoring (SHM) systems consist of sensors in the scale of hundreds, each sensor generating extremely large amounts of data, often arousing the issue of the cost associated with data transfer and storage. Sensor energy is a major component included in this cost factor, especially in Wireless Sensor Networks (WSN). Data compression is one of the techniques that is being explored to mitigate the effects of these issues. In contrast to traditional data compression techniques, Compressive Sensing (CS) - a very recent development - introduces the means of accurately reproducing a signal by acquiring much less number of samples than that defined by Nyquist's theorem. CS achieves this task by exploiting the sparsity of the signal. By the reduced amount of data samples, CS may help reduce the energy consumption and storage costs associated with SHM systems. This paper investigates CS based data acquisition in SHM, in particular, the implications of CS on damage detection and localization. CS is implemented in a simulation environment to compress structural response data from a Reinforced Concrete (RC) structure. Promising results were obtained from the compressed data reconstruction process as well as the subsequent damage identification process using the reconstructed data. A reconstruction accuracy of 99% could be achieved at a Compression Ratio (CR) of 2.48 using the experimental data. Further analysis using the reconstructed signals provided accurate damage detection and localization results using two damage detection algorithms, showing that CS has not compromised the crucial information on structural damages during the compression process.

  7. IgM Repertoire Biodiversity is Reduced in HIV-1 Infection and Systemic Lupus Erythematosus.

    PubMed

    Yin, Li; Hou, Wei; Liu, Li; Cai, Yunpeng; Wallet, Mark Andrew; Gardner, Brent Paul; Chang, Kaifen; Lowe, Amanda Catherine; Rodriguez, Carina Adriana; Sriaroon, Panida; Farmerie, William George; Sleasman, John William; Goodenow, Maureen Michels

    2013-01-01

    HIV-1 infection or systemic lupus erythematosus (SLE) disrupt B cell homeostasis, reduce memory B cells, and impair function of IgG and IgM antibodies. To determine how disturbances in B cell populations producing polyclonal antibodies relate to the IgM repertoire, the IgM transcriptome in health and disease was explored at the complementarity determining region 3 (CDRH3) sequence level. 454-deep pyrosequencing in combination with a novel analysis pipeline was applied to define populations of IGHM CDRH3 sequences based on absence or presence of somatic hypermutations (SHM) in peripheral blood B cells. HIV or SLE subjects have reduced biodiversity within their IGHM transcriptome compared to healthy subjects, mainly due to a significant decrease in the number of unique combinations of alleles, although recombination machinery was intact. While major differences between sequences without or with SHM occurred among all groups, IGHD and IGHJ allele use, CDRH3 length distribution, or generation of SHM were similar among study cohorts. Antiretroviral therapy failed to normalize IGHM biodiversity in HIV-infected individuals. All subjects had a low frequency of allelic combinations within the IGHM repertoire similar to known broadly neutralizing HIV-1 antibodies. Polyclonal expansion would decrease overall IgM biodiversity independent of other mechanisms for development of the B cell repertoire. Applying deep sequencing as a strategy to follow development of the IgM repertoire in health and disease provides a novel molecular assessment of multiple points along the B cell differentiation pathway that is highly sensitive for detecting perturbations within the repertoire at the population level.

  8. Light weight, high-speed, and self-powered wireless fiber optic sensor (WiFOS) structural health monitor system for avionics and aerospace environments

    NASA Astrophysics Data System (ADS)

    Mendoza, Edgar A.; Kempen, Cornelia; Sun, Sunjian; Esterkin, Yan

    2014-09-01

    This paper describes recent progress towards the development of an innovative light weight, high-speed, and selfpowered wireless fiber optic sensor (WiFOS™) structural health monitor system suitable for the onboard and in-flight unattended detection, localization, and classification of load, fatigue, and structural damage in advanced composite materials commonly used in avionics and aerospace systems. The WiFOS™ system is based on ROI's advancements on monolithic photonic integrated circuit microchip technology, integrated with smart power management, on-board data processing, wireless data transmission optoelectronics, and self-power using energy harvesting tools such as solar, vibration, thermoelectric, and magneto-electric. The self-powered, wireless WiFOS™ system offers a versatile and powerful SHM tool to enhance the reliability and safety of avionics platforms, jet fighters, helicopters, commercial aircraft that use lightweight composite material structures, by providing comprehensive information about the structural integrity of the structure from a large number of locations. Immediate SHM applications are found in rotorcraft and aircraft, ships, submarines, and in next generation weapon systems, and in commercial oil and petrochemical, aerospace industries, civil structures, power utilities, portable medical devices, and biotechnology, homeland security and a wide spectrum of other applications.

  9. Bio-Inspired Stretchable Network-Based Intelligent Composites

    DTIC Science & Technology

    2012-05-03

    on par with that of lead zirconate titanate ( PZT ). This shows that the BSPT piezo-transducer has the potential to function in ultrasonic situations as...well as the PZTs typically used As a final test, the full network was used, with the same data acquisition computer, designed for PZT - based networks...ality of BSPT in SHM systems. These experiments indicate that BSPT has function- ality on par with PZT -5A and can simply replace the PZT in existing

  10. Long-Term Durability and Integrity of Built-In Piezoelectric-Based Active Sensing Network in Structures

    DTIC Science & Technology

    2007-03-31

    iterating to the end-time step. 1.3 Code Verification 1.3.1 Statement of the Problem A square aluminum alloy plate (thickness = 1.02 mm, width and...plate. The electro-mechanical properties of the piezoelectric materials (APC850) are available from American Piezoceramics, Inc. . The piezoceramic...structural usage and provide an early indication of physical damage. Piezoelectric (PZT) based SHM systems are among the most widely used for active and

  11. Uncertainty quantification in structural health monitoring: Applications on cultural heritage buildings

    NASA Astrophysics Data System (ADS)

    Lorenzoni, Filippo; Casarin, Filippo; Caldon, Mauro; Islami, Kleidi; Modena, Claudio

    2016-01-01

    In the last decades the need for an effective seismic protection and vulnerability reduction of cultural heritage buildings and sites determined a growing interest in structural health monitoring (SHM) as a knowledge-based assessment tool to quantify and reduce uncertainties regarding their structural performance. Monitoring can be successfully implemented in some cases as an alternative to interventions or to control the medium- and long-term effectiveness of already applied strengthening solutions. The research group at the University of Padua, in collaboration with public administrations, has recently installed several SHM systems on heritage structures. The paper reports the application of monitoring strategies implemented to avoid (or at least minimize) the execution of strengthening interventions/repairs and control the response as long as a clear worsening or damaging process is detected. Two emblematic case studies are presented and discussed: the Roman Amphitheatre (Arena) of Verona and the Conegliano Cathedral. Both are excellent examples of on-going monitoring activities, performed through static and dynamic approaches in combination with automated procedures to extract meaningful structural features from collected data. In parallel to the application of innovative monitoring techniques, statistical models and data processing algorithms have been developed and applied in order to reduce uncertainties and exploit monitoring results for an effective assessment and protection of historical constructions. Processing software for SHM was implemented to perform the continuous real time treatment of static data and the identification of modal parameters based on the structural response to ambient vibrations. Statistical models were also developed to filter out the environmental effects and thermal cycles from the extracted features.

  12. Kalman filter based data fusion for neutral axis tracking in wind turbine towers

    NASA Astrophysics Data System (ADS)

    Soman, Rohan; Malinowski, Pawel; Ostachowicz, Wieslaw; Paulsen, Uwe S.

    2015-03-01

    Wind energy is seen as one of the most promising solutions to man's ever increasing demands of a clean source of energy. In particular to reduce the cost of energy (COE) generated, there are efforts to increase the life-time of the wind turbines, to reduce maintenance costs and to ensure high availability. Maintenance costs may be lowered and the high availability and low repair costs ensured through the use of condition monitoring (CM) and structural health monitoring (SHM). SHM allows early detection of damage and allows maintenance planning. Furthermore, it can allow us to avoid unnecessary downtime, hence increasing the availability of the system. The present work is based on the use of neutral axis (NA) for SHM of the structure. The NA is tracked by data fusion of measured yaw angle and strain through the use of Extended Kalman Filter (EKF). The EKF allows accurate tracking even in the presence of changing ambient conditions. NA is defined as the line or plane in the section of the beam which does not experience any tensile or compressive forces when loaded. The NA is the property of the cross section of the tower and is independent of the applied loads and ambient conditions. Any change in the NA position may be used for detecting and locating the damage. The wind turbine tower has been modelled with FE software ABAQUS and validated on data from load measurements carried out on the 34m high tower of the Nordtank, NTK 500/41 wind turbine.

  13. Small-strain measurement in bridge connections using the digital image correlation (DIC) technique

    NASA Astrophysics Data System (ADS)

    Desai, Niranjan

    2016-04-01

    Structural health monitoring (SHM) is emerging as a vital tool to help civil engineers improve the safety, maintainability, and reliability of critical structures and assists infrastructure owners with timely information for the continued safe and economic operation of their structure. SHM involves implementing a strategy that identifies and characterizes damage or undesirable performance in engineering structures. The goal of this research project was to determine the smallest strains measurable using standard digital image correlation (DIC) based SHM equipment. This practical investigation that had strong ties to the industry was motivated by damage observed in a real-world bridge, which was initially undetected. Its early detection would have led to reduced repair costs. To accomplish the aforementioned goal, tests were performed on a laboratory specimen that replicated a steel beam-to-column connection of the concerned bridge, involving progressively loading it in a manner in which it was loaded in the actual bridge, while simultaneously measuring the strains that developed in it using the aforementioned DIC-based equipment and software. Under the controlled conditions in the laboratory, the minimum resolution of the state-of-the-art system used in this investigation was determined. Due to the challenges faced in making these small-strain measurements even under highly controlled laboratory conditions, it was concluded that it is currently unrealistic to use the existing DIC technology in a real-world situation to measure strains as small as those that would need to be measured to detect the onset of damage in bridge connections. More work needs to be done in this area.

  14. In-situ health monitoring of piezoelectric sensors using electromechanical impedance: A numerical perspective

    NASA Astrophysics Data System (ADS)

    Bilgunde, Prathamesh N.; Bond, Leonard J.

    2018-04-01

    Current work presents a numerical investigation to classify the in-situ health of the piezoelectric sensors deployed for structural health monitoring (SHM) of large civil, aircraft and automotive structures. The methodology proposed in this work attempts to model the in-homogeneities in the adhesive with which typically the sensor is bonded to the structure for SHM. It was found that weakening of the bond state causes reduction in the resonance frequency of the structure and eventually approaches the resonance characteristics of a piezoelectric material under traction-free boundary conditions. These changes in the resonance spectrum are further quantified using root mean square deviation-based damage index. Results demonstrate that the electromechanical impedance method can be used to monitor structural integrity of the sensor bonded to the host structure. This cost-effective method can potentially reduce misinterpretation of SHM data for critical infrastructures.

  15. Manufacturing technology of integrated textile-based sensor networks for in situ monitoring applications of composite wind turbine blades

    NASA Astrophysics Data System (ADS)

    Haentzsche, Eric; Mueller, Ralf; Huebner, Matthias; Ruder, Tristan; Unger, Reimar; Nocke, Andreas; Cherif, Chokri

    2016-10-01

    Based on in situ strain sensors consisting of piezo-resistive carbon filament yarns (CFYs), which have been successfully integrated into textile reinforcement structures during their textile-technological manufacturing process, a continuous load of fibre-reinforced plastic (FRP) components has been realised. These sensors are also suitable for structural health monitoring (SHM) applications. The two-dimensional sensor layout is made feasible by the usage of a modular warp yarn path manipulation unit. Using a functional model of a small wind turbine blade in thermoset composite design, the sensor function for basic SHM applications (e.g. static load monitoring) are demonstrated. Any mechanical loads along the pressure or suction side of the wind turbine blade can be measured and calculated via a correlative change in resistance of the CFYs within the textile reinforcement plies. Performing quasi-static load tests on both tensile specimen and full-scale wind turbine blade, elementary results have been obtained concerning electro-mechanical behaviour and spatial resolution of global and even local static stresses according to the CFY sensor integration length. This paper demonstrates the great potential of textile-based and textile-technological integrated sensors in reinforcement structures for future SHM applications of FRPs.

  16. Schwertmannite stability in anoxic Fe(II)-rich aqueous solution

    NASA Astrophysics Data System (ADS)

    Paikaray, Susanta; Schröder, Christian; Peiffer, Stefan

    2017-11-01

    Schwertmannite (SHM) is a powerful scavenger for As(III) leading to As(III)-enriched precipitates around acid mine drainage environments that may become exposed to aqueous Fe(II). In this study we have investigated the stability of pure SHM and SHM containing 0.92 wt% As(III) under Fe(II)aq-rich (0.4-1.0 mM) anoxic conditions using XRD, SEM, Mössbauer and FTIR spectroscopic techniques. Schwertmannite transformation proceeded through an alkalinity-driven pathway releasing sulfate and a Fe(II)-catalyzed pathway that generated lepidocrocite and goethite at pH 6 and 6.9 in the presence of 1 mM Fe(II)aq. Lepidocrocite was found to be needle shaped if the SHM contained As(III) and platy for pure SHM. Goethite had a poor degree of crystallinity in As(III) containing SHM. Pre-adsorption of As(III) inhibited the extent of SHM transformation. Fe(II) sorption onto SHM was pH dependent and reflected a sorption edge with complete consumption at pH 6.9, while only ∼20% were adsorbed at pH 5. Surface coverage with Fe(II) appears to be the key parameter controlling extent and products of the transformation process. As(III) concentrations in solution are controlled by two mechanisms: (1) exchange of As(III) for sulfate upon alkalinity-driven transformation of schwertmannite and (2) re-adsorption to new phases formed upon Fe(II)-catalyzed transformation. The adsorbed As(III) has inhibited the extent of transformation and was partly released with the maximum release at pH 5 (0.5%) in the absence of Fe(II)aq.

  17. A Wireless MEMS-Based Inclinometer Sensor Node for Structural Health Monitoring

    PubMed Central

    Ha, Dae Woong; Park, Hyo Seon; Choi, Se Woon; Kim, Yousok

    2013-01-01

    This paper proposes a wireless inclinometer sensor node for structural health monitoring (SHM) that can be applied to civil engineering and building structures subjected to various loadings. The inclinometer used in this study employs a method for calculating the tilt based on the difference between the static acceleration and the acceleration due to gravity, using a micro-electro-mechanical system (MEMS)-based accelerometer. A wireless sensor node was developed through which tilt measurement data are wirelessly transmitted to a monitoring server. This node consists of a slave node that uses a short-distance wireless communication system (RF 2.4 GHz) and a master node that uses a long-distance telecommunication system (code division multiple access—CDMA). The communication distance limitation, which is recognized as an important issue in wireless monitoring systems, has been resolved via these two wireless communication components. The reliability of the proposed wireless inclinometer sensor node was verified experimentally by comparing the values measured by the inclinometer and subsequently transferred to the monitoring server via wired and wireless transfer methods to permit a performance evaluation of the wireless communication sensor nodes. The experimental results indicated that the two systems (wired and wireless transfer systems) yielded almost identical values at a tilt angle greater than 1°, and a uniform difference was observed at a tilt angle less than 0.42° (approximately 0.0032° corresponding to 0.76% of the tilt angle, 0.42°) regardless of the tilt size. This result was deemed to be within the allowable range of measurement error in SHM. Thus, the wireless transfer system proposed in this study was experimentally verified for practical application in a structural health monitoring system. PMID:24287533

  18. Structural Health Monitoring Using Textile Reinforcement Structures with Integrated Optical Fiber Sensors

    PubMed Central

    Bremer, Kort; Weigand, Frank; Zheng, Yulong; Alwis, Lourdes Shanika; Helbig, Reinhard; Roth, Bernhard

    2017-01-01

    Optical fiber-based sensors “embedded” in functionalized carbon structures (FCSs) and textile net structures (TNSs) based on alkaline-resistant glass are introduced for the purpose of structural health monitoring (SHM) of concrete-based structures. The design aims to monitor common SHM parameters such as strain and cracks while at the same time acting as a structural strengthening mechanism. The sensor performances of the two systems are characterized in situ using Mach-Zehnder interferometric (MZI) and optical attenuation measurement techniques, respectively. For this purpose, different FCS samples were subjected to varying elongation using a tensile testing machine by carefully incrementing the applied force, and good correlation between the applied force and measured length change was observed. For crack detection, the functionalized TNSs were embedded into a concrete block which was then exposed to varying load using the three-point flexural test until destruction. Promising results were observed, identifying that the location of the crack can be determined using the conventional optical time domain reflectometry (OTDR) technique. The embedded sensors thus evaluated show the value of the dual achievement of the schemes proposed in obtaining strain/crack measurement while being utilized as strengthening agents as well. PMID:28208636

  19. Integrated solutions to SHM problems: an overview of SHM research at the LANL/UCSD engineering institute

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Farrar, Charles; Park, Gyuhae; Farinholt, Kevin

    2010-12-08

    This seminar will provide an overview of structural health monitoring (SHM) research that is being undertaken at Los Alamos National Laboratory (LANL). The seminar will begin by stating that SHM should be viewed as an important component of the more comprehensive intelligent life-cycle engineering process. Then LANL's statistical pattern recognition paradigm for addressing SHM problems will be introduced and current research that is focused on each part of the paradigm will be discussed. In th is paradigm, the process can be broken down into four parts: (1) Operational Evaluation, (2) Data Acquisition and Cleansing, (3) Feature Extraction, and (4) Statisticalmore » Model Development for Feature Discrimination. When one attempts to apply this paradigm to data from real world structures, it quickly becomes apparent that the ability to cleanse, compress, normalize and fuse data to account for operational and environmental variability is a key implementation issue when addressing Parts 2-4 of this paradigm. This discussion will be followed by the introduction a new project entitled 'Intelligent Wind Turbines' which is the focus of much of our current SHM research . This summary will be followed by a discussion of issues that must be addressed if this technology is to make the transition from research to practice and new research directions that are emerging for SHM.« less

  20. A feasibility study on embedded micro-electromechanical sensors and systems (MEMS) for monitoring highway structures.

    DOT National Transportation Integrated Search

    2011-06-01

    Micro-electromechanical systems (MEMS) provide vast improvements over existing sensing methods in the context of structural health monitoring (SHM) of highway infrastructure systems, including improved system reliability, improved longevity and enhan...

  1. Remote monitoring of bond line defects between a composite panel and a stiffener using distributed piezoelectric sensors

    NASA Astrophysics Data System (ADS)

    Yu, Xudong; Fan, Zheng; Puliyakote, Sreedhar; Castaings, Michel

    2018-03-01

    Structural health monitoring (SHM) using ultrasonic guided waves has proven to be attractive for the identification of damage in composite plate-like structures, due to its realization of both significant propagation distances and reasonable sensitivity to defects. However, topographical features such as bends, lap joints, and bonded stiffeners are often encountered in these structures, and they are susceptible to various types of defects as a consequence of stress concentration and cyclic loading during the service life. Therefore, the health condition of such features has to be assessed effectively to ensure the safe operation of the entire structure. This paper proposes a novel feature guided wave (FGW) based SHM strategy, in which proper FGWs are exploited as a screening tool to rapidly interrogate the representative stiffener-adhesive bond-composite skin assembly. An array of sensors permanently attached to the vicinity of the feature is used to capture scattered waves from the localized damage occurring in the bond line. This technique is combined with an imaging approach, and the damage reconstruction is achieved by the synthetic focusing algorithm using these scattered signals. The proposed SHM scheme is implemented in both the 3D finite element simulation and the experiment, and the results are in good agreement, demonstrating the feasibility of such SHM strategy.

  2. Mass and stiffness estimation using mobile devices for structural health monitoring

    NASA Astrophysics Data System (ADS)

    Le, Viet; Yu, Tzuyang

    2015-04-01

    In the structural health monitoring (SHM) of civil infrastructure, dynamic methods using mass, damping, and stiffness for characterizing structural health have been a traditional and widely used approach. Changes in these system parameters over time indicate the progress of structural degradation or deterioration. In these methods, capability of predicting system parameters is essential to their success. In this paper, research work on the development of a dynamic SHM method based on perturbation analysis is reported. The concept is to use externally applied mass to perturb an unknown system and measure the natural frequency of the system. Derived theoretical expressions for mass and stiffness prediction are experimentally verified by a building model. Dynamic responses of the building model perturbed by various masses in free vibration were experimentally measured by a mobile device (cell phone) to extract the natural frequency of the building model. Single-degreeof- freedom (SDOF) modeling approach was adopted for the sake of using a cell phone. From the experimental result, it is shown that the percentage error of predicted mass increases when the mass ratio increases, while the percentage error of predicted stiffness decreases when the mass ratio increases. This work also demonstrated the potential use of mobile devices in the health monitoring of civil infrastructure.

  3. Challenges of NDE Simulation Tool Challenges of NDE Simulation Tool

    NASA Technical Reports Server (NTRS)

    Leckey, Cara A. C.; Juarez, Peter D.; Seebo, Jeffrey P.; Frank, Ashley L.

    2015-01-01

    Realistic nondestructive evaluation (NDE) simulation tools enable inspection optimization and predictions of inspectability for new aerospace materials and designs. NDE simulation tools may someday aid in the design and certification of advanced aerospace components; potentially shortening the time from material development to implementation by industry and government. Furthermore, modeling and simulation are expected to play a significant future role in validating the capabilities and limitations of guided wave based structural health monitoring (SHM) systems. The current state-of-the-art in ultrasonic NDE/SHM simulation cannot rapidly simulate damage detection techniques for large scale, complex geometry composite components/vehicles with realistic damage types. This paper discusses some of the challenges of model development and validation for composites, such as the level of realism and scale of simulation needed for NASA' applications. Ongoing model development work is described along with examples of model validation studies. The paper will also discuss examples of the use of simulation tools at NASA to develop new damage characterization methods, and associated challenges of validating those methods.

  4. Structural Health Monitoring for a Z-Type Special Vehicle

    PubMed Central

    Yuan, Chaolin; Ren, Liang; Li, Hongnan

    2017-01-01

    Nowadays there exist various kinds of special vehicles designed for some purposes, which are different from regular vehicles in overall dimension and design. In that case, accidents such as overturning will lead to large economical loss and casualties. There are still no technical specifications to follow to ensure the safe operation and driving of these special vehicles. Owing to the poor efficiency of regular maintenance, it is more feasible and effective to apply real-time monitoring during the operation and driving process. In this paper, the fiber Bragg grating (FBG) sensors are used to monitor the safety of a z-type special vehicle. Based on the structural features and force distribution, a reasonable structural health monitoring (SHM) scheme is presented. Comparing the monitoring results with the finite element simulation results guarantees the accuracy and reliability of the monitoring results. Large amounts of data are collected during the operation and driving progress to evaluate the structural safety condition and provide reference for SHM systems developed for other special vehicles. PMID:28587161

  5. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Santos, Bruno; Carvalho, Paulo F.; Rodrigues, A.P.

    The ATCA standard specifies a mandatory Shelf Manager (ShM) unit which is a key element for the system operation. It includes the Intelligent Platform Management Controller (IPMC) which monitors the system health, retrieves inventory information and controls the Field Replaceable Units (FRUs). These elements enable the intelligent health monitoring, providing high-availability and safety operation, ensuring the correct system operation. For critical systems like ones of tokamak ITER these features are mandatory to support the long pulse operation. The Nominal Device Support (NDS) was designed and developed for the ITER CODAC Core System (CCS), which will be the responsible for plantmore » Instrumentation and Control (I and C), supervising and monitoring on ITER. It generalizes the Enhanced Physics and Industrial Control System (EPICS) device support interface for Data Acquisition (DAQ) and timing devices. However the support for health management features and ATCA ShM are not yet provided. This paper presents the implementation and test of a NDS for the ATCA ShM, using the ITER Fast Plant System Controller (FPSC) prototype environment. This prototype is fully compatible with the ITER CCS and uses the EPICS Channel Access (CA) protocol as the interface with the Plant Operation Network (PON). The implemented solution running in an EPICS Input / Output Controller (IOC) provides Process Variables (PV) to the PON network with the system information. These PVs can be used for control and monitoring by all CA clients, such as EPICS user interface clients and alarm systems. The results are presented, demonstrating the fully integration and the usability of this solution. (authors)« less

  6. Damage Identification of Wind Turbine Blades Using Piezoelectric Transducers

    DOE PAGES

    Choi, Seong-Won; Farinholt, Kevin M.; Taylor, Stuart G.; ...

    2014-01-01

    This paper presents the experimental results of active-sensing structural health monitoring (SHM) techniques, which utilize piezoelectric transducers as sensors and actuators, for determining the structural integrity of wind turbine blades. Specifically, Lamb wave propagations and frequency response functions at high frequency ranges are used to estimate the condition of wind turbine blades. For experiments, a 1 m section of a CX-100 blade is used. The goal of this study is to assess and compare the performance of each method in identifying incipient damage with a consideration given to field deployability. Overall, these methods yielded a sufficient damage detection capability to warrantmore » further investigation. This paper also summarizes the SHM results of a full-scale fatigue test of a 9 m CX-100 blade using piezoelectric active sensors. This paper outlines considerations needed to design such SHM systems, experimental procedures and results, and additional issues that can be used as guidelines for future investigations.« less

  7. Monitoring Space Weather Hazards caused by geomagnetic disturbances with Space Hazard Monitor (SHM) systems

    NASA Astrophysics Data System (ADS)

    Xu, Z.; Gannon, J. L.; Peek, T. A.; Lin, D.

    2017-12-01

    One space weather hazard is the Geomagnetically Induced Currents (GICs) in the electric power transmission systems, which is naturally induced geoelectric field during the geomagnetic disturbances (GMDs). GICs are a potentially catastrophic threat to bulk power systems. For instance, the Blackout in Quebec in March 1989 was caused by GMDs during a significant magnetic storm. To monitor the GMDs, the autonomous Space Hazard Monitor (SHM) system is developed recently. The system includes magnetic field measurement from magnetometers and geomagnetic field measurement from electrodes. In this presentation, we introduce the six sites of SHMs which have been deployed in the US continental regions. The data from the magnetometers are processed with the Multiple Observatory Geomagnetic Data Analysis Software (MOGDAS). And the statistical results are presented here. It reveals not only the impacts of space weather over US continental region but also the potential of improving instrumentation development to provide better space weather monitor.

  8. Electromagnetomechanical elastodynamic model for Lamb wave damage quantification in composites

    NASA Astrophysics Data System (ADS)

    Borkowski, Luke; Chattopadhyay, Aditi

    2014-03-01

    Physics-based wave propagation computational models play a key role in structural health monitoring (SHM) and the development of improved damage quantification methodologies. Guided waves (GWs), such as Lamb waves, provide the capability to monitor large plate-like aerospace structures with limited actuators and sensors and are sensitive to small scale damage; however due to the complex nature of GWs, accurate and efficient computation tools are necessary to investigate the mechanisms responsible for dispersion, coupling, and interaction with damage. In this paper, the local interaction simulation approach (LISA) coupled with the sharp interface model (SIM) solution methodology is used to solve the fully coupled electro-magneto-mechanical elastodynamic equations for the piezoelectric and piezomagnetic actuation and sensing of GWs in fiber reinforced composite material systems. The final framework provides the full three-dimensional displacement as well as electrical and magnetic potential fields for arbitrary plate and transducer geometries and excitation waveform and frequency. The model is validated experimentally and proven computationally efficient for a laminated composite plate. Studies are performed with surface bonded piezoelectric and embedded piezomagnetic sensors to gain insight into the physics of experimental techniques used for SHM. The symmetric collocation of piezoelectric actuators is modeled to demonstrate mode suppression in laminated composites for the purpose of damage detection. The effect of delamination and damage (i.e., matrix cracking) on the GW propagation is demonstrated and quantified. The developed model provides a valuable tool for the improvement of SHM techniques due to its proven accuracy and computational efficiency.

  9. Vibration-based damage detection in wind turbine blades using Phase-based Motion Estimation and motion magnification

    NASA Astrophysics Data System (ADS)

    Sarrafi, Aral; Mao, Zhu; Niezrecki, Christopher; Poozesh, Peyman

    2018-05-01

    Vibration-based Structural Health Monitoring (SHM) techniques are among the most common approaches for structural damage identification. The presence of damage in structures may be identified by monitoring the changes in dynamic behavior subject to external loading, and is typically performed by using experimental modal analysis (EMA) or operational modal analysis (OMA). These tools for SHM normally require a limited number of physically attached transducers (e.g. accelerometers) in order to record the response of the structure for further analysis. Signal conditioners, wires, wireless receivers and a data acquisition system (DAQ) are also typical components of traditional sensing systems used in vibration-based SHM. However, instrumentation of lightweight structures with contact sensors such as accelerometers may induce mass-loading effects, and for large-scale structures, the instrumentation is labor intensive and time consuming. Achieving high spatial measurement resolution for a large-scale structure is not always feasible while working with traditional contact sensors, and there is also the potential for a lack of reliability associated with fixed contact sensors in outliving the life-span of the host structure. Among the state-of-the-art non-contact measurements, digital video cameras are able to rapidly collect high-density spatial information from structures remotely. In this paper, the subtle motions from recorded video (i.e. a sequence of images) are extracted by means of Phase-based Motion Estimation (PME) and the extracted information is used to conduct damage identification on a 2.3-m long Skystream® wind turbine blade (WTB). The PME and phased-based motion magnification approach estimates the structural motion from the captured sequence of images for both a baseline and damaged test cases on a wind turbine blade. Operational deflection shapes of the test articles are also quantified and compared for the baseline and damaged states. In addition, having proper lighting while working with high-speed cameras can be an issue, therefore image enhancement and contrast manipulation has also been performed to enhance the raw images. Ultimately, the extracted resonant frequencies and operational deflection shapes are used to detect the presence of damage, demonstrating the feasibility of implementing non-contact video measurements to perform realistic structural damage detection.

  10. BRILIA: Integrated Tool for High-Throughput Annotation and Lineage Tree Assembly of B-Cell Repertoires.

    PubMed

    Lee, Donald W; Khavrutskii, Ilja V; Wallqvist, Anders; Bavari, Sina; Cooper, Christopher L; Chaudhury, Sidhartha

    2016-01-01

    The somatic diversity of antigen-recognizing B-cell receptors (BCRs) arises from Variable (V), Diversity (D), and Joining (J) (VDJ) recombination and somatic hypermutation (SHM) during B-cell development and affinity maturation. The VDJ junction of the BCR heavy chain forms the highly variable complementarity determining region 3 (CDR3), which plays a critical role in antigen specificity and binding affinity. Tracking the selection and mutation of the CDR3 can be useful in characterizing humoral responses to infection and vaccination. Although tens to hundreds of thousands of unique BCR genes within an expressed B-cell repertoire can now be resolved with high-throughput sequencing, tracking SHMs is still challenging because existing annotation methods are often limited by poor annotation coverage, inconsistent SHM identification across the VDJ junction, or lack of B-cell lineage data. Here, we present B-cell repertoire inductive lineage and immunosequence annotator (BRILIA), an algorithm that leverages repertoire-wide sequencing data to globally improve the VDJ annotation coverage, lineage tree assembly, and SHM identification. On benchmark tests against simulated human and mouse BCR repertoires, BRILIA correctly annotated germline and clonally expanded sequences with 94 and 70% accuracy, respectively, and it has a 90% SHM-positive prediction rate in the CDR3 of heavily mutated sequences; these are substantial improvements over existing methods. We used BRILIA to process BCR sequences obtained from splenic germinal center B cells extracted from C57BL/6 mice. BRILIA returned robust B-cell lineage trees and yielded SHM patterns that are consistent across the VDJ junction and agree with known biological mechanisms of SHM. By contrast, existing BCR annotation tools, which do not account for repertoire-wide clonal relationships, systematically underestimated both the size of clonally related B-cell clusters and yielded inconsistent SHM frequencies. We demonstrate BRILIA's utility in B-cell repertoire studies related to VDJ gene usage, mechanisms for adenosine mutations, and SHM hot spot motifs. Furthermore, we show that the complete gene usage annotation and SHM identification across the entire CDR3 are essential for studying the B-cell affinity maturation process through immunosequencing methods.

  11. Crack propagation monitoring in a full-scale aircraft fatigue test based on guided wave-Gaussian mixture model

    NASA Astrophysics Data System (ADS)

    Qiu, Lei; Yuan, Shenfang; Bao, Qiao; Mei, Hanfei; Ren, Yuanqiang

    2016-05-01

    For aerospace application of structural health monitoring (SHM) technology, the problem of reliable damage monitoring under time-varying conditions must be addressed and the SHM technology has to be fully validated on real aircraft structures under realistic load conditions on ground before it can reach the status of flight test. In this paper, the guided wave (GW) based SHM method is applied to a full-scale aircraft fatigue test which is one of the most similar test status to the flight test. To deal with the time-varying problem, a GW-Gaussian mixture model (GW-GMM) is proposed. The probability characteristic of GW features, which is introduced by time-varying conditions is modeled by GW-GMM. The weak cumulative variation trend of the crack propagation, which is mixed in time-varying influence can be tracked by the GW-GMM migration during on-line damage monitoring process. A best match based Kullback-Leibler divergence is proposed to measure the GW-GMM migration degree to reveal the crack propagation. The method is validated in the full-scale aircraft fatigue test. The validation results indicate that the reliable crack propagation monitoring of the left landing gear spar and the right wing panel under realistic load conditions are achieved.

  12. Development of Self-Powered Wireless Structural Health Monitoring (SHM) for Wind Turbine Blades

    NASA Astrophysics Data System (ADS)

    Lim, Dong-Won

    Wind turbine blade failure can lead to unexpected power interruptions. Monitoring wind turbine blades is important to ensure seamless electricity delivery from power generation to consumers. Structural health monitoring (SHM) enables early recognition of structural problems so that the safety and reliability of operation can be enhanced. This dissertation focuses on the development of a wireless SHM system for wind turbine blades. The sensor is comprised of a piezoelectric energy harvester (EH) and a telemetry unit. The sensor node is mounted on the blade surface. As the blade rotates, the blade flexes, and the energy harvester captures the strain energy on the blade surface. Once sufficient electricity is captured, a pulse is sent from the sensing node to a gateway. Then, a central monitoring algorithm processes a series of pulses received from all three blades. This wireless SHM, which uses commercially available components, can be retrofitted to existing turbines. The harvested energy for sensing can be estimated in terms of two factors: the available strain energy and conversion efficiency. The available strain energy was evaluated using the FAST (Fatigue, Aerodynamics, Structures, and Turbulence) simulator. The conversion efficiency was studied analytically and experimentally. An experimental set-up was designed to mimic the expected strain frequency and amplitude for rotor blades. From a series of experiments, the efficiency of a piezoelectric EH at a typical rotor speed (0.2 Hz) was approximately 0.5%. The power requirement for sending one measurement (280 muJ) can be achieved in 10 minutes. Designing a detection algorithm is challenging due to this low sampling rate. A new sensing approach-the timing of pulses from the transmitter-was introduced. This pulse timing, which is tied to the charging time, is indicative of the structural health. The SHM system exploits the inherent triple redundancy of the three blades. The timing data of the three blades are compared to discern an outlier, corresponding to a damaged blade. Two types of post-processing of pulses were investigated: (1) comparing the ratios of signal timings (i.e. transmission ratio); and (2) comparing the difference between signal timings (i.e. residuals). For either method, damage is indicated when the energy ratio or residual exceeds a threshold level. When residuals are used to detect damage, performance measures such as the false alarm rate and detection probability can also be imposed. The SHM algorithms were evaluated using strain energy data from a 2.5 MW wind turbine.

  13. In situ health monitoring for bogie systems of CRH380 train on Beijing-Shanghai high-speed railway

    NASA Astrophysics Data System (ADS)

    Hong, Ming; Wang, Qiang; Su, Zhongqing; Cheng, Li

    2014-04-01

    Based on the authors' research efforts over the years, an in situ structural health monitoring (SHM) technique taking advantage of guided elastic waves has been developed and deployed via an online diagnosis system. The technique and the system were recently implemented on China's latest high-speed train (CRH380CL) operated on Beijing-Shanghai High-Speed Railway. The system incorporated modularized components including active sensor network, active wave generation, multi-channel data acquisition, signal processing, data fusion, and results presentation. The sensor network, inspired by a new concept—"decentralized standard sensing", was integrated into the bogie frames during the final assembly of CRH380CL, to generate and acquire bogie-guided ultrasonic waves, from which a wide array of signal features were extracted. Fusion of signal features through a diagnostic imaging algorithm led to a graphic illustration of the overall health state of the bogie in a real-time and intuitive manner. The in situ experimentation covered a variety of high-speed train operation events including startup, acceleration/deceleration, full-speed operation (300 km/h), emergency braking, track change, as well as full stop. Mock-up damage affixed to the bogie was identified quantitatively and visualized in images. This in situ testing has demonstrated the feasibility, effectiveness, sensitivity, and reliability of the developed SHM technique and the system towards real-world applications.

  14. Defect classification in sparsity-based structural health monitoring

    NASA Astrophysics Data System (ADS)

    Golato, Andrew; Ahmad, Fauzia; Santhanam, Sridhar; Amin, Moeness G.

    2017-05-01

    Guided waves have gained popularity in structural health monitoring (SHM) due to their ability to inspect large areas with little attenuation, while providing rich interactions with defects. For thin-walled structures, the propagating waves are Lamb waves, which are a complex but well understood type of guided waves. Recent works have cast the defect localization problem of Lamb wave based SHM within the sparse reconstruction framework. These methods make use of a linear model relating the measurements with the scene reflectivity under the assumption of point-like defects. However, most structural defects are not perfect points but tend to assume specific forms, such as surface cracks or internal cracks. Knowledge of the "type" of defects is useful in the assessment phase of SHM. In this paper, we present a dual purpose sparsity-based imaging scheme which, in addition to accurately localizing defects, properly classifies the defects present simultaneously. The proposed approach takes advantage of the bias exhibited by certain types of defects toward a specific Lamb wave mode. For example, some defects strongly interact with the anti-symmetric modes, while others strongly interact with the symmetric modes. We build model based dictionaries for the fundamental symmetric and anti-symmetric wave modes, which are then utilized in unison to properly localize and classify the defects present. Simulated data of surface and internal defects in a thin Aluminum plate are used to validate the proposed scheme.

  15. Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus.

    PubMed

    Ott, Jeannine A; Castro, Caitlin D; Deiss, Thaddeus C; Ohta, Yuko; Flajnik, Martin F; Criscitiello, Michael F

    2018-04-17

    Since the discovery of the T cell receptor (TcR), immunologists have assigned somatic hypermutation (SHM) as a mechanism employed solely by B cells to diversify their antigen receptors. Remarkably, we found SHM acting in the thymus on α chain locus of shark TcR. SHM in developing shark T cells likely is catalyzed by activation-induced cytidine deaminase (AID) and results in both point and tandem mutations that accumulate non-conservative amino acid replacements within complementarity-determining regions (CDRs). Mutation frequency at TcRα was as high as that seen at B cell receptor loci (BcR) in sharks and mammals, and the mechanism of SHM shares unique characteristics first detected at shark BcR loci. Additionally, fluorescence in situ hybridization showed the strongest AID expression in thymic corticomedullary junction and medulla. We suggest that TcRα utilizes SHM to broaden diversification of the primary αβ T cell repertoire in sharks, the first reported use in vertebrates. © 2018, Ott et al.

  16. Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus

    PubMed Central

    Ott, Jeannine A; Castro, Caitlin D; Deiss, Thaddeus C; Ohta, Yuko; Flajnik, Martin F

    2018-01-01

    Since the discovery of the T cell receptor (TcR), immunologists have assigned somatic hypermutation (SHM) as a mechanism employed solely by B cells to diversify their antigen receptors. Remarkably, we found SHM acting in the thymus on α chain locus of shark TcR. SHM in developing shark T cells likely is catalyzed by activation-induced cytidine deaminase (AID) and results in both point and tandem mutations that accumulate non-conservative amino acid replacements within complementarity-determining regions (CDRs). Mutation frequency at TcRα was as high as that seen at B cell receptor loci (BcR) in sharks and mammals, and the mechanism of SHM shares unique characteristics first detected at shark BcR loci. Additionally, fluorescence in situ hybridization showed the strongest AID expression in thymic corticomedullary junction and medulla. We suggest that TcRα utilizes SHM to broaden diversification of the primary αβ T cell repertoire in sharks, the first reported use in vertebrates. PMID:29664399

  17. Damage prognosis: the future of structural health monitoring.

    PubMed

    Farrar, Charles R; Lieven, Nick A J

    2007-02-15

    This paper concludes the theme issue on structural health monitoring (SHM) by discussing the concept of damage prognosis (DP). DP attempts to forecast system performance by assessing the current damage state of the system (i.e. SHM), estimating the future loading environments for that system, and predicting through simulation and past experience the remaining useful life of the system. The successful development of a DP capability will require the further development and integration of many technology areas including both measurement/processing/telemetry hardware and a variety of deterministic and probabilistic predictive modelling capabilities, as well as the ability to quantify the uncertainty in these predictions. The multidisciplinary and challenging nature of the DP problem, its current embryonic state of development, and its tremendous potential for life-safety and economic benefits qualify DP as a 'grand challenge' problem for engineers in the twenty-first century.

  18. Structural health monitoring for ship structures

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Farrar, Charles; Park, Gyuhae; Angel, Marian

    2009-01-01

    Currently the Office of Naval Research is supporting the development of structural health monitoring (SHM) technology for U.S. Navy ship structures. This application is particularly challenging because of the physical size of these structures, the widely varying and often extreme operational and environmental conditions associated with these ships missions, lack of data from known damage conditions, limited sensing that was not designed specifically for SHM, and the management of the vast amounts of data that can be collected during a mission. This paper will first define a statistical pattern recognition paradigm for SHM by describing the four steps of (1)more » Operational Evaluation, (2) Data Acquisition, (3) Feature Extraction, and (4) Statistical Classification of Features as they apply to ship structures. Note that inherent in the last three steps of this process are additional tasks of data cleansing, compression, normalization and fusion. The presentation will discuss ship structure SHM challenges in the context of applying various SHM approaches to sea trials data measured on an aluminum multi-hull high-speed ship, the HSV-2 Swift. To conclude, the paper will discuss several outstanding issues that need to be addressed before SHM can make the transition from a research topic to actual field applications on ship structures and suggest approaches for addressing these issues.« less

  19. SELF CALIBRATED STMR ARRAY FOR MATERIAL CHARACTERIZATION AND SHM OF ORTHOTROPIC PLATE-LIKE STRUCTURES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vishnuvardhan, J.; Muralidharan, Ajith; Balasubramaniam, Krishnan

    A full ring STMR array patch had been used for Structural Health Monitoring (SHM) of anisotropic materials where the elastic moduli, correspond to the virgin sample, were used in the calculations. In the present work an in-situ SHM has been successfully demonstrated using a novel compact sensor patch (Double ring single quadrant small footprint STMR array) through simultaneous reconstruction of the elastic moduli, material symmetry, orientation of principal planes and defect imaging. The direct received signals were used to measure Lamb wave velocities, which were used in a slowness based reconstructed algorithm using Genetic Algorithm to reconstruct the elastic moduli,more » material symmetry and orientation of principal planes. The measured signals along with the reconstructed elastic moduli were used in the phased addition algorithm for imaging the damages present on the structure. To show the applicability of the method, simulations were carried out with the double ring single quadrant STMR array configuration to image defects and are compared with the images obtained using simulation data of the full ring STMR array configuration. The experimental validation has been carried out using 3.15 mm quasi-isotropic graphite-epoxy composite. The double ring single quadrant STMR array has advantages over the full ring STMR array as it can carry out in-situ SHM with limited footprint on the structure.« less

  20. Application of Multiplexed FBG and PZT Impedance Sensors for Health Monitoring of Rocks.

    PubMed

    Yang, Yaowen; Annamdas, Venu Gopal Madhav; Wang, Chao; Zhou, Yingxin

    2008-01-21

    Reliable structural health monitoring (SHM) including nondestructiveevaluation (NDE) is essential for safe operation of infrastructure systems. Effectivemonitoring of the rock components of civil infrastructures such as tunnels and cavernsremains challenging. The feasibility of employing smart optical fibre sensor (OFS) andpiezoelectric impedance sensor made up of lead zirconate titanate (PZT) forcomprehensive health monitoring of rocks, covering load history monitoring/retrieval aswell as damage assessment is presented in this paper. The rock specimens are subjected tocyclic loading and their conditions are continuously monitored using OFS and PZTsensors. OFS based multiplexed fibre Bragg grating (FBG) sensors are surface bonded onthe rock specimens. Their strain sensing performance is compared with the conventionalelectric strain gauges (ESGs). In addition, PZT patches are also bonded on the specimensto study the damage pattern during different loading cycles. Unlike the FBGs or ESGs,PZT patches are used as bi-functional sensors and actuators, enabling them to be efficientdetectors of incipient damages using the principle of electromechanical impedance. Theexperimental study demonstrated superior performance of these smart FBG and PZTimpedance sensors. This work is expected to be useful for SHM based NDE application ofrock structures such as caverns and tunnels.

  1. Assessing somatic hypermutation in Ramos B cells after overexpression or knockdown of specific genes.

    PubMed

    Upton, Dana C; Unniraman, Shyam

    2011-11-01

    B cells start their life with low affinity antibodies generated by V(D)J recombination. However, upon detecting a pathogen, the variable (V) region of an immunoglobulin (Ig) gene is mutated approximately 100,000-fold more than the rest of the genome through somatic hypermutation (SHM), resulting in high affinity antibodies. In addition, class switch recombination (CSR) produces antibodies with different effector functions depending on the kind of immune response that is needed for a particular pathogen. Both CSR and SHM are initiated by activation-induced cytidine deaminase (AID), which deaminates cytosine residues in DNA to produce uracils. These uracils are processed by error-prone forms of repair pathways, eventually leading to mutations and recombination. Our current understanding of the molecular details of SHM and CSR come from a combination of studies in mice, primary cells, cell lines, and cell-free experiments. Mouse models remain the gold standard with genetic knockouts showing critical roles for many repair factors (e.g. Ung, Msh2, Msh6, Exo1, and polymerase η). However, not all genes are amenable for knockout studies. For example, knockouts of several double-strand break repair proteins are embryonically lethal or impair B-cell development. Moreover, sometimes the specific function of a protein in SHM or CSR may be masked by more global defects caused by the knockout. In addition, since experiments in mice can be lengthy, altering expression of individual genes in cell lines has become an increasingly popular first step to identifying and characterizing candidate genes. Ramos - a Burkitt lymphoma cell line that constitutively undergoes SHM - has been a popular cell-line model to study SHM. One advantage of Ramos cells is that they have a built-in convenient semi-quantitative measure of SHM. Wild type cells express IgM and, as they pick up mutations, some of the mutations knock out IgM expression. Therefore, assaying IgM loss by fluorescence-activated cell scanning (FACS) provides a quick read-out for the level of SHM. A more quantitative measurement of SHM can be obtained by directly sequencing the antibody genes. Since Ramos cells are difficult to transfect, we produce stable derivatives that have increased or lowered expression of an individual gene by infecting cells with retroviral or lentiviral constructs that contain either an overexpression cassette or a short hairpin RNA (shRNA), respectively. Here, we describe how we infect Ramos cells and then use these cells to investigate the role of specific genes on SHM (Figure 1).

  2. Comparing model-based adaptive LMS filters and a model-free hysteresis loop analysis method for structural health monitoring

    NASA Astrophysics Data System (ADS)

    Zhou, Cong; Chase, J. Geoffrey; Rodgers, Geoffrey W.; Xu, Chao

    2017-02-01

    The model-free hysteresis loop analysis (HLA) method for structural health monitoring (SHM) has significant advantages over the traditional model-based SHM methods that require a suitable baseline model to represent the actual system response. This paper provides a unique validation against both an experimental reinforced concrete (RC) building and a calibrated numerical model to delineate the capability of the model-free HLA method and the adaptive least mean squares (LMS) model-based method in detecting, localizing and quantifying damage that may not be visible, observable in overall structural response. Results clearly show the model-free HLA method is capable of adapting to changes in how structures transfer load or demand across structural elements over time and multiple events of different size. However, the adaptive LMS model-based method presented an image of greater spread of lesser damage over time and story when the baseline model is not well defined. Finally, the two algorithms are tested over a simpler hysteretic behaviour typical steel structure to quantify the impact of model mismatch between the baseline model used for identification and the actual response. The overall results highlight the need for model-based methods to have an appropriate model that can capture the observed response, in order to yield accurate results, even in small events where the structure remains linear.

  3. Probabilistic Structural Health Monitoring of the Orbiter Wing Leading Edge

    NASA Technical Reports Server (NTRS)

    Yap, Keng C.; Macias, Jesus; Kaouk, Mohamed; Gafka, Tammy L.; Kerr, Justin H.

    2011-01-01

    A structural health monitoring (SHM) system can contribute to the risk management of a structure operating under hazardous conditions. An example is the Wing Leading Edge Impact Detection System (WLEIDS) that monitors the debris hazards to the Space Shuttle Orbiter s Reinforced Carbon-Carbon (RCC) panels. Since Return-to-Flight (RTF) after the Columbia accident, WLEIDS was developed and subsequently deployed on board the Orbiter to detect ascent and on-orbit debris impacts, so as to support the assessment of wing leading edge structural integrity prior to Orbiter re-entry. As SHM is inherently an inverse problem, the analyses involved, including those performed for WLEIDS, tend to be associated with significant uncertainty. The use of probabilistic approaches to handle the uncertainty has resulted in the successful implementation of many development and application milestones.

  4. Health monitoring of offshore structures using wireless sensor network: experimental investigations

    NASA Astrophysics Data System (ADS)

    Chandrasekaran, Srinivasan; Chitambaram, Thailammai

    2016-04-01

    This paper presents a detailed methodology of deploying wireless sensor network in offshore structures for structural health monitoring (SHM). Traditional SHM is carried out by visual inspections and wired systems, which are complicated and requires larger installation space to deploy while decommissioning is a tedious process. Wireless sensor networks can enhance the art of health monitoring with deployment of scalable and dense sensor network, which consumes lesser space and lower power consumption. Proposed methodology is mainly focused to determine the status of serviceability of large floating platforms under environmental loads using wireless sensors. Data acquired by the servers will analyze the data for their exceedance with respect to the threshold values. On failure, SHM architecture will trigger an alarm or an early warning in the form of alert messages to alert the engineer-in-charge on board; emergency response plans can then be subsequently activated, which shall minimize the risk involved apart from mitigating economic losses occurring from the accidents. In the present study, wired and wireless sensors are installed in the experimental model and the structural response, acquired is compared. The wireless system comprises of Raspberry pi board, which is programmed to transmit the acquired data to the server using Wi-Fi adapter. Data is then hosted in the webpage for further post-processing, as desired.

  5. Integration of bridge damage detection concepts and components, volume III : wireless bridge monitoring hardware.

    DOT National Transportation Integrated Search

    2013-10-01

    In this work, a previously developed structural health monitoring (SHM) system was advanced toward a ready-for-implementation : system. Improvements were made with respect to automated data reduction/analysis, data acquisition hardware, sensor types,...

  6. A comparative evaluation of piezoelectric sensors for acoustic emission-based impact location estimation and damage classification in composite structures

    NASA Astrophysics Data System (ADS)

    Uprety, Bibhisha; Kim, Sungwon; Mathews, V. John; Adams, Daniel O.

    2015-03-01

    Acoustic Emission (AE) based Structural Health Monitoring (SHM) is of great interest for detecting impact damage in composite structures. Within the aerospace industry the need to detect and locate these events, even when no visible damage is present, is important both from the maintenance and design perspectives. In this investigation, four commercially available piezoelectric sensors were evaluated for usage in an AE-based SHM system. Of particular interest was comparing the acoustic response of the candidate piezoelectric sensors for impact location estimations as well as damage classification resulting from the impact in fiber-reinforced composite structures. Sensor assessment was performed based on response signal characterization and performance for active testing at 300 kHz and steel-ball drop testing using both aluminum and carbon/epoxy composite plates. Wave mode velocities calculated from the measured arrival times were found to be in good agreement with predictions obtained using both the Disperse code and finite element analysis. Differences in the relative strength of the received wave modes, the overall signal strengths and signal-to-noise ratios were observed through the use of both active testing as well as passive steel-ball drop testing. Further comparative is focusing on assessing AE sensor performance for use in impact location estimation algorithms as well as detecting and classifying damage produced in composite structures due to impact events.

  7. Uniform circular array for structural health monitoring of composite structures

    NASA Astrophysics Data System (ADS)

    Stepinski, Tadeusz; Engholm, Marcus

    2008-03-01

    Phased array with all-azimuth angle coverage would be extremely useful in structural health monitoring (SHM) of planar structures. One method to achieve the 360° coverage is to use uniform circular arrays (UCAs). In this paper we present the concept of UCA adapted for SHM applications. We start from a brief presentation of UCA beamformers based on the principle of phase mode excitation. UCA performance is illustrated by the results of beamformer simulations performed for the narrowband and wideband ultrasonic signals. Preliminary experimental results obtained with UCA used for the reception of ultrasonic signals propagating in an aluminum plate are also presented.

  8. Thermal, Electrical and Surface Hydrophobic Properties of Electrospun Polyacrylonitrile Nanofibers for Structural Health Monitoring

    PubMed Central

    Alarifi, Ibrahim M.; Alharbi, Abdulaziz; Khan, Waseem S.; Swindle, Andrew; Asmatulu, Ramazan

    2015-01-01

    This paper presents an idea of using carbonized electrospun Polyacrylonitrile (PAN) fibers as a sensor material in a structural health monitoring (SHM) system. The electrospun PAN fibers are lightweight, less costly and do not interfere with the functioning of infrastructure. This study deals with the fabrication of PAN-based nanofibers via electrospinning followed by stabilization and carbonization in order to remove all non-carbonaceous material and ensure pure carbon fibers as the resulting material. Electrochemical impedance spectroscopy was used to determine the ionic conductivity of PAN fibers. The X-ray diffraction study showed that the repeated peaks near 42° on the activated nanofiber film were α and β phases, respectively, with crystalline forms. Contact angle, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR) were also employed to examine the surface, thermal and chemical properties of the carbonized electrospun PAN fibers. The test results indicated that the carbonized PAN nanofibers have superior physical properties, which may be useful for structural health monitoring (SHM) applications in different industries. PMID:28793615

  9. Cointegration and Nonstationarity in the Context of Multiresolution Analysis

    NASA Astrophysics Data System (ADS)

    Worden, K.; Cross, E. J.; Kyprianou, A.

    2011-07-01

    Cointegration has established itself as a powerful means of projecting out long-term trends from time-series data in the context of econometrics. Recent work by the current authors has further established that cointegration can be applied profitably in the context of structural health monitoring (SHM), where it is desirable to project out the effects of environmental and operational variations from data in order that they do not generate false positives in diagnostic tests. The concept of cointegration is partly built on a clear understanding of the ideas of stationarity and nonstationarity for time-series. Nonstationarity in this context is 'traditionally' established through the use of statistical tests, e.g. the hypothesis test based on the augmented Dickey-Fuller statistic. However, it is important to understand the distinction in this case between 'trend' stationarity and stationarity of the AR models typically fitted as part of the analysis process. The current paper will discuss this distinction in the context of SHM data and will extend the discussion by the introduction of multi-resolution (discrete wavelet) analysis as a means of characterising the time-scales on which nonstationarity manifests itself. The discussion will be based on synthetic data and also on experimental data for the guided-wave SHM of a composite plate.

  10. Integrating SHM and Time Variant System Performance of Naval Ship Structures For Near Real Time Decision Making Under Uncertainty: A Comprehensive Framework

    DTIC Science & Technology

    2016-12-06

    direction and speed based on cost minimization and best estimated time of arrival (ETA). Sometimes, ships are forced to travel 43 Lehigh Technical...the allowable time to complete the travel . Another important aspect, addressed in the case study, is to investigate the optimal routing of aged...The public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing

  11. High affinity IgM(+) memory B cells are generated through a germinal center-dependent pathway.

    PubMed

    Hara, Yasushi; Tashiro, Yasuyuki; Murakami, Akikazu; Nishimura, Miyuki; Shimizu, Takeyuki; Kubo, Masato; Burrows, Peter D; Azuma, Takachika

    2015-12-01

    During a T cell-dependent immune response, B cells undergo clonal expansion and selection and the induction of isotype switching and somatic hypermutation (SHM). Although somatically mutated IgM(+) memory B cells have been reported, it has not been established whether they are really high affinity B cells. We tracked (4-hydroxy-3-nitrophenyl) acetyl hapten-specific GC B cells from normal immunized mice based on affinity of their B cell receptor (BCR) and performed BCR sequence analysis. SHM was evident by day 7 postimmunization and increased with time, such that high affinity IgM(+) as well as IgG(+) memory B cells continued to be generated up to day 42. In contrast, class-switch recombination (CSR) was almost completed by day 7 and then the ratio of IgG1(+)/IgM(+) GC B cells remained unchanged. Together these findings suggest that IgM(+) B cells undergo SHM in the GC to generate high affinity IgM(+) memory cells and that this process continues even after CSR is accomplished. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. FOREWORD: Structural Health Monitoring and Intelligent Infrastructure

    NASA Astrophysics Data System (ADS)

    Wu, Zhishen; Fujino, Yozo

    2005-06-01

    This special issue collects together 19 papers that were originally presented at the First International Conference on Structural Health Monitoring and Intelligent Infrastructure (SHMII-1'2003), held in Tokyo, Japan, on 13-15 November 2003. This conference was organized by the Japan Society of Civil Engineers (JSCE) with partial financial support from the Japan Society for the Promotion of Science (JSPS) and the Ministry of Education, Culture, Sport, Science and Technology, Japan. Many related organizations supported the conference. A total of 16 keynote papers including six state-of-the-art reports from different counties, six invited papers and 154 contributed papers were presented at the conference. The conference was attended by a diverse group of about 300 people from a variety of disciplines in academia, industry and government from all over the world. Structural health monitoring (SHM) and intelligent materials, structures and systems have been the subject of intense research and development in the last two decades and, in recent years, an increasing range of applications in infrastructure have been discovered both for existing structures and for new constructions. SHMII-1'2003 addressed progress in the development of building, transportation, marine, underground and energy-generating structures, and other civilian infrastructures that are periodically, continuously and/or actively monitored where there is a need to optimize their performance. In order to focus the current needs on SHM and intelligent technologies, the conference theme was set as 'Structures/Infrastructures Sustainability'. We are pleased to have the privilege to edit this special issue on SHM and intelligent infrastructure based on SHMII-1'2003. We invited some of the presenters to submit a revised/extended version of their paper that was included in the SHMII-1'2003 proceedings for possible publication in the special issue. Each paper included in this special issue was edited with the same quality standards as for any paper in a regular issue. The papers cover a wide spectrum of topics including smart and effective sensing technologies, reliable approaches to signal processing, rational data gathering and interpretation methods, advanced damage characterization, modeling feature selection and diagnosis methods, and system integration technologies, etc. This special issue contains the most up-to-date achievements in SHM and intelligent technologies and provides information pertaining to their current and potential applications in infrastructure. It is our hope that this special issue makes a significant contribution in advancing awareness and acceptance of SHM and intelligent technologies for the maintenance and construction of different kinds of infrastructure. We would like to express our sincere thanks to Professor Varadan (Editor-in-Chief), Professor Matsuzaki (Regional Editor), the Editorial Assistants and the staff at Institute of Physics Publishing for their great support and advice in publishing this special issue. Special thanks are due to all the reviewers for their willingness to share their time and expertise. Final but important thanks go to Ms Suzhen Li (Doctorate Candidate at Ibaraki University) for her assistance in editing this special issue.

  13. Research on multi-parameter monitoring of steel frame shaking-table test using smartphone

    NASA Astrophysics Data System (ADS)

    Han, Ruicong; Loh, Kenneth J.; Zhao, Xuefeng; Yu, Yan

    2017-04-01

    The numerical simulation promises an effective method to assess seismic damage of high-rise structure. But it's difficult to determine the input parameters and the simulation results are not completely consistent with the real condition. A more direct approach to evaluate the seismic damage is the structural health monitoring (SHM), which is one complex set of various kinds of sensors, devices and software, and always needs professionals. SHM system has achieved great development over recent years, especially on bridge structures. However it's not so popular on high-rise building due to its difficult implementation. Developing a low-cost and convenient monitoring technique will be helpful for the safety maintenance of high-rise building. Smartphones, which embedded with sensors, network transmission, data storage and processing system, are evolving towards crowdsourcing. The popularity of smartphones presents opportunities for implementation of portable SHM system on buildings. In this paper, multi-parameter monitoring of a three-story steel frame on shaking table under earthquake excitations was conducted with smartphone, and the comparison between smartphone and traditional sensors was provided. First, the monitoring applications on iOS platform, Orion-CC and D-viewer, were introduced. Then the experimental details were presented, including three-story frame model, sensors placement, viscous dampers and so on. Last, the acceleration and displacement time-history curves of smartphone and traditional sensors are provided and compared to prove the feasibility of the monitoring on frame under earthquake excitations by smartphone.

  14. Experimental application of OMA solutions on the model of industrial structure

    NASA Astrophysics Data System (ADS)

    Mironov, A.; Mironovs, D.

    2017-10-01

    It is very important and sometimes even vital to maintain reliability of industrial structures. High quality control during production and structural health monitoring (SHM) in exploitation provides reliable functioning of large, massive and remote structures, like wind generators, pipelines, power line posts, etc. This paper introduces a complex of technological and methodical solutions for SHM and diagnostics of industrial structures, including those that are actuated by periodic forces. Solutions were verified on a wind generator scaled model with integrated system of piezo-film deformation sensors. Simultaneous and multi-patch Operational Modal Analysis (OMA) approaches were implemented as methodical means for structural diagnostics and monitoring. Specially designed data processing algorithms provide objective evaluation of structural state modification.

  15. The relation between open-field and emergence tests in a hyperactive mouse model.

    PubMed

    Lalonde, R; Strazielle, C

    2009-12-01

    The relation between open-field and emergence tests was examined in mice with idiopathic hypertension. Spontaneous hypertensive mice (SHM) crossed more segments and reared more often in the open-field than normotensive controls at both age levels. In contrast, grooming episodes decreased only in the older SHM cohort. While young SHM emerged more quickly from a toy object only partially, complete emergence was faster only in the older SHM cohort. In the entire series, open-field segments were inversely correlated with 2- and 4-paw emergence latencies. There was also an inverse correlation between rears and 2-paw emergence but a positive correlation between grooming episodes and both types of emergence. In view of its association with open-field activity, the emergence test may have value in screening potential ADHD therapies.

  16. An arm wearable haptic interface for impact sensing on unmanned aerial vehicles

    NASA Astrophysics Data System (ADS)

    Choi, Yunshil; Hong, Seung-Chan; Lee, Jung-Ryul

    2017-04-01

    In this paper, an impact monitoring system using fiber Bragg grating (FBG) sensors and vibro-haptic actuators has been introduced. The system is suggested for structural health monitoring (SHM) for unmanned aerial vehicles (UAVs), by making a decision with human-robot interaction. The system is composed with two major subsystems; an on-board system equipped on UAV and an arm-wearable interface for ground pilot. The on-board system acquires impact-induced wavelength changes and performs localization process, which was developed based on arrival time calculation. The arm-wearable interface helps ground pilots to make decision about impact location themselves by stimulating their tactile-sense with motor vibration.

  17. Experimental Investigation on Acousto-Ultrasonic Sensing Using Polarization-Maintaining Fiber Bragg Gratings

    NASA Technical Reports Server (NTRS)

    Wang, Gang; Banks, Curtis E.

    2015-01-01

    This report discusses the guided Lamb wave sensing using polarization-maintaining (PM) fiber Bragg grating (PM-FBG) sensor. The goal is to apply the PM-FBG sensor system to composite structural health monitoring (SHM) applications in order to realize directivity and multi-axis strain sensing capabilities while using reduced number of sensors. Comprehensive experiments were conducted to evaluate the performance of the PM-FBG sensor in a composite panel structure under different actuation frequencies and locations. Three Macro-Fiber-Composite (MFC) piezoelectric actuators were used to generate guided Lamb waves and they are oriented at 0, 45, and 90 degrees with respect to PM-FBG axial direction, respectively. The actuation frequency was varied from 20kHz to 200kHz. It is shown that the PM-FBG sensor system is able to detect high-speed ultrasound waves and capture the characteristics under different actuation conditions. Both longitudinal and lateral strain components in the order of nano-strain were determined based on the reflective intensity measurement data from fast and slow axis of the PM fiber. It must be emphasized that this is the first attempt to investigate acousto-ultrasonic sensing using PM-FBG sensor. This could lead to a new sensing approach in the SHM applications.

  18. Experimental Investigation on Acousto-ultrasonic Sensing Using Polarization-Maintaining Fiber Bragg Gratings

    NASA Technical Reports Server (NTRS)

    Wang, Gag; Banks, Curtis E.

    2016-01-01

    This report discusses the guided Lamb wave sensing using polarization-maintaining (PM) fiber Bragg grating (PM-FBG) sensor. The goal is to apply the PM-FBG sensor system to composite structural health monitoring (SHM) applications in order to realize directivity and multi-axis strain sensing capabilities while reducing the number of sensors. Comprehensive experiments were conducted to evaluate the performance of the PM-FBG sensor attached to a composite panel structure under different actuation frequencies and locations. Three Macro-Fiber-Composite (MFC) piezoelectric actuators were used to generate guided Lamb waves that were oriented at 0, 45, and 90 degrees with respect to PM-FBG axial direction, respectively. The actuation frequency was varied from 20kHz to 200kHz. It was shown that the PM-FBG sensor system was able to detect high-speed ultrasound waves and capture the characteristics under different actuation conditions. Both longitudinal and lateral strain components in the order of nano-strain were determined based on the reflective intensity measurement data from fast and slow axis of the PM fiber. It must be emphasized that this is the first attempt to investigate acouto-ultrasonic sensing using PM-FBG sensor. This could lead to a new sensing approach in the SHM applications. Nomenclature.

  19. An Improved Gaussian Mixture Model for Damage Propagation Monitoring of an Aircraft Wing Spar under Changing Structural Boundary Conditions.

    PubMed

    Qiu, Lei; Yuan, Shenfang; Mei, Hanfei; Fang, Fang

    2016-02-26

    Structural Health Monitoring (SHM) technology is considered to be a key technology to reduce the maintenance cost and meanwhile ensure the operational safety of aircraft structures. It has gradually developed from theoretic and fundamental research to real-world engineering applications in recent decades. The problem of reliable damage monitoring under time-varying conditions is a main issue for the aerospace engineering applications of SHM technology. Among the existing SHM methods, Guided Wave (GW) and piezoelectric sensor-based SHM technique is a promising method due to its high damage sensitivity and long monitoring range. Nevertheless the reliability problem should be addressed. Several methods including environmental parameter compensation, baseline signal dependency reduction and data normalization, have been well studied but limitations remain. This paper proposes a damage propagation monitoring method based on an improved Gaussian Mixture Model (GMM). It can be used on-line without any structural mechanical model and a priori knowledge of damage and time-varying conditions. With this method, a baseline GMM is constructed first based on the GW features obtained under time-varying conditions when the structure under monitoring is in the healthy state. When a new GW feature is obtained during the on-line damage monitoring process, the GMM can be updated by an adaptive migration mechanism including dynamic learning and Gaussian components split-merge. The mixture probability distribution structure of the GMM and the number of Gaussian components can be optimized adaptively. Then an on-line GMM can be obtained. Finally, a best match based Kullback-Leibler (KL) divergence is studied to measure the migration degree between the baseline GMM and the on-line GMM to reveal the weak cumulative changes of the damage propagation mixed in the time-varying influence. A wing spar of an aircraft is used to validate the proposed method. The results indicate that the crack propagation under changing structural boundary conditions can be monitored reliably. The method is not limited by the properties of the structure, and thus it is feasible to be applied to composite structure.

  20. Application of Multiplexed FBG and PZT Impedance Sensors for Health Monitoring of Rocks

    PubMed Central

    Yang, Yaowen; Annamdas, Venu Gopal Madhav; Wang, Chao; Zhou, Yingxin

    2008-01-01

    Reliable structural health monitoring (SHM) including nondestructive evaluation (NDE) is essential for safe operation of infrastructure systems. Effective monitoring of the rock components of civil infrastructures such as tunnels and caverns remains challenging. The feasibility of employing smart optical fibre sensor (OFS) and piezoelectric impedance sensor made up of lead zirconate titanate (PZT) for comprehensive health monitoring of rocks, covering load history monitoring/retrieval as well as damage assessment is presented in this paper. The rock specimens are subjected to cyclic loading and their conditions are continuously monitored using OFS and PZT sensors. OFS based multiplexed fibre Bragg grating (FBG) sensors are surface bonded on the rock specimens. Their strain sensing performance is compared with the conventional electric strain gauges (ESGs). In addition, PZT patches are also bonded on the specimens to study the damage pattern during different loading cycles. Unlike the FBGs or ESGs, PZT patches are used as bi-functional sensors and actuators, enabling them to be efficient detectors of incipient damages using the principle of electromechanical impedance. The experimental study demonstrated superior performance of these smart FBG and PZT impedance sensors. This work is expected to be useful for SHM based NDE application of rock structures such as caverns and tunnels. PMID:27879708

  1. A novel optical investigation technique for railroad track inspection and assessment

    NASA Astrophysics Data System (ADS)

    Sabato, Alessandro; Beale, Christopher H.; Niezrecki, Christopher

    2017-04-01

    Track failures due to cross tie degradation or loss in ballast support may result in a number of problems ranging from simple service interruptions to derailments. Structural Health Monitoring (SHM) of railway track is important for safety reasons and to reduce downtime and maintenance costs. For this reason, novel and cost-effective track inspection technologies for assessing tracks' health are currently insufficient and needed. Advancements achieved in recent years in cameras technology, optical sensors, and image-processing algorithms have made machine vision, Structure from Motion (SfM), and three-dimensional (3D) Digital Image Correlation (DIC) systems extremely appealing techniques for extracting structural deformations and geometry profiles. Therefore, optically based, non-contact measurement techniques may be used for assessing surface defects, rail and tie deflection profiles, and ballast condition. In this study, the design of two camera-based measurement systems is proposed for crossties-ballast condition assessment and track examination purposes. The first one consists of four pairs of cameras installed on the underside of a rail car to detect the induced deformation and displacement on the whole length of the track's cross tie using 3D DIC measurement techniques. The second consists of another set of cameras using SfM techniques for obtaining a 3D rendering of the infrastructure from a series of two-dimensional (2D) images to evaluate the state of the track qualitatively. The feasibility of the proposed optical systems is evaluated through extensive laboratory tests, demonstrating their ability to measure parameters of interest (e.g. crosstie's full-field displacement, vertical deflection, shape, etc.) for assessment and SHM of railroad track.

  2. Modal content based damage indicators and phased array transducers for structural health monitoring of aircraft structures using ultrasonic guided waves

    NASA Astrophysics Data System (ADS)

    Ren, Baiyang

    Composite materials, especially carbon fiber reinforced polymers (CFRP), have been widely used in the aircraft industry because of their high specific strength and stiffness, resistance to corrosion and good fatigue life. Due to their highly anisotropic material properties and laminated structures, joining methods like bolting and riveting are no longer appropriate for joining CFRP since they initiate defects during the assembly and severely compromise the integrity of the structure; thus new techniques for joining CFRP are highly demanded. Adhesive bonding is a promising method because it relieves stress concentration, reduces weight and provides smooth surfaces. Additionally, it is a low-cost alternative to the co-cured method which is currently used to manufacture components of aircraft fuselage. Adhesive defects, disbonds at the interface between adherend and adhesive layer, are focused on in this thesis because they can be initialized by either poor surface preparation during the manufacturing or fatigue loads during service. Aircraft need structural health monitoring (SHM) systems to increase safety and reduce loss, and adhesive bonds usually represent the hotspots of the assembled structure. There are many nondestructive evaluation (NDE) methods for bond inspection. However, these methods cannot be readily integrated into an SHM system because of the bulk size and weight of the equipment and requirement of accessibility to one side of the bonded joint. The first objective of this work is to develop instruments, actuators, sensors and a data acquisition system for SHM of bond lines using ultrasonic guided waves which are well known to be able to cover large volume of the structure and inaccessible regions. Different from widely used guided wave sensors like PZT disks, the new actuators, piezoelectric fiber composite (PFC) phased array transducers0 (PAT), can control the modal content of the excited waves and the new sensors, polyvinylidene fluoride (PVDF) arrays, which can extract modal information from the received waves. Also, the PATs and array sensors have broad frequency bandwidth and can easily excite and receive high order guided wave modes which are not possible using PZT disks. Currently, many guided wave SHM techniques employ the fundamental guided wave modes below the first cut-off frequency because of their low dispersion in this frequency range. Such a practice ignores the possibility of using higher order modes which sometimes have much better sensitivity to defects. A frequency domain finite element model is created in this work to study the behavior of the interaction between guided waves and a disbond. The sensitivities of modes are classified into three levels, namely, good sensitivity, intermediate sensitivity and no sensitivity. The novel damage indicators, wave modal amplitude and wave modal composition, are proposed to increase the sensitivity to disbonds. The effects of environmental operational conditions (EOC) are presenting great challenges to reliable SHM practice because they may influence the wave amplitude and time of flight. The use of fundamental modes shows poor sensitivity to the disbond; but the use of higher order modes shows good sensitivity. The experiments demonstrate that the new damage indicators have excellent sensitivity to disbonds even with elevated temperatures and have the capability to characterize the size of a disbond. Additionally, the detection of other types of defects like notches on aluminum plates and disbonds in adhesively bonded aluminum plate are also demonstrated using the proposed damage indicators. The use of the new damage indicators for SHM applications relies on the capability of resolving the modal content of wave signals which is enabled only by using PFC PATs and polyvinylidene fluoride (PVDF) array sensors.

  3. Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes

    PubMed Central

    Detanico, Thiago; Phillips, Matthew; Wysocki, Lawrence J.

    2016-01-01

    In systemic autoimmunity, autoantibodies directed against nuclear antigens (Ags) often arise by somatic hypermutation (SHM) that converts AGT and AGC (AGY) Ser codons into Arg codons. This can occur by three different single-base changes. Curiously, AGY Ser codons are far more abundant in complementarity-determining regions (CDRs) of IgV-region genes than expected for random codon use or from species-specific codon frequency data. CDR AGY codons are also more abundant than TCN Ser codons. We show that these trends hold even in cartilaginous fishes. Because AGC is a preferred target for SHM by activation-induced cytidine deaminase, we asked whether the AGY abundance was solely due to a selection pressure to conserve high mutability in CDRs regardless of codon context but found that this was not the case. Instead, AGY triplets were selectively enriched in the Ser codon reading frame. Motivated by reports implicating a functional role for poly/autoreactive specificities in antiviral antibodies, we also analyzed mutations at AGY in antibodies directed against a number of different viruses and found that mutations producing Arg codons in antiviral antibodies were indeed frequent. Unexpectedly, however, we also found that AGY codons mutated often to encode nearly all of the amino acids that are reported to provide the most frequent contacts with Ag. In many cases, mutations producing codons for these alternative amino acids in antiviral antibodies were more frequent than those producing Arg codons. Mutations producing each of these key amino acids required only single-base changes in AGY. AGY is the only codon group in which two-thirds of random mutations generate codons for these key residues. Finally, by directly analyzing X-ray structures of immune complexes from the RCSB protein database, we found that Ag-contact residues generated via SHM occurred more often at AGY than at any other codon group. Thus, preservation of AGY codons in antibody genes appears to have been driven by their exceptional functional versatility, despite potential autoreactive consequences. PMID:27920779

  4. Load monitoring of aerospace structures utilizing micro-electro-mechanical systems for static and quasi-static loading conditions

    NASA Astrophysics Data System (ADS)

    Martinez, M.; Rocha, B.; Li, M.; Shi, G.; Beltempo, A.; Rutledge, R.; Yanishevsky, M.

    2012-11-01

    The National Research Council Canada (NRC) has worked on the development of structural health monitoring (SHM) test platforms for assessing the performance of sensor systems for load monitoring applications. The first SHM platform consists of a 5.5 m cantilever aluminum beam that provides an optimal scenario for evaluating the ability of a load monitoring system to measure bending, torsion and shear loads. The second SHM platform contains an added level of structural complexity, by consisting of aluminum skins with bonded/riveted stringers, typical of an aircraft lower wing structure. These two load monitoring platforms are well characterized and documented, providing loading conditions similar to those encountered during service. In this study, a micro-electro-mechanical system (MEMS) for acquiring data from triads of gyroscopes, accelerometers and magnetometers is described. The system was used to compute changes in angles at discrete stations along the platforms. The angles obtained from the MEMS were used to compute a second, third or fourth order degree polynomial surface from which displacements at every point could be computed. The use of a new Kalman filter was evaluated for angle estimation, from which displacements in the structure were computed. The outputs of the newly developed algorithms were then compared to the displacements obtained from the linear variable displacement transducers connected to the platforms. The displacement curves were subsequently post-processed either analytically, or with the help of a finite element model of the structure, to estimate strains and loads. The estimated strains were compared with baseline strain gauge instrumentation installed on the platforms. This new approach for load monitoring was able to provide accurate estimates of applied strains and shear loads.

  5. Self-actuating and self-diagnosing plastically deforming piezo-composite flapping wing MAV

    NASA Astrophysics Data System (ADS)

    Harish, Ajay B.; Harursampath, Dineshkumar; Mahapatra, D. Roy

    2011-04-01

    In this work, we propose a constitutive model to describe the behavior of Piezoelectric Fiber Reinforced Composite (PFRC) material consisting of elasto-plastic matrix reinforced by strong elastic piezoelectric fibers. Computational efficiency is achieved using analytical solutions for elastic stifness matrix derived from Variational Asymptotic Methods (VAM). This is extended to provide Structural Health Monitoring (SHM) based on plasticity induced degradation of flapping frequency of PFRC. Overall this work provides an effective mathematical tool that can be used for structural self-health monitoring of plasticity induced flapping degradation of PFRC flapping wing MAVs. The developed tool can be re-calibrated to also provide SHM for other forms of failures like fatigue, matrix cracking etc.

  6. Coupling Sensing Hardware with Data Interrogation Software for Structural Health Monitoring

    DOE PAGES

    Farrar, Charles R.; Allen, David W.; Park, Gyuhae; ...

    2006-01-01

    The process of implementing a damage detection strategy for aerospace, civil and mechanical engineering infrastructure is referred to as structural health monitoring (SHM). The authors' approach is to address the SHM problem in the context of a statistical pattern recognition paradigm. In this paradigm, the process can be broken down into four parts: (1) Operational Evaluation, (2) Data Acquisition and Cleansing, (3) Feature Extraction and Data Compression, and (4) Statistical Model Development for Feature Discrimination. These processes must be implemented through hardware or software and, in general, some combination of these two approaches will be used. This paper will discussmore » each portion of the SHM process with particular emphasis on the coupling of a general purpose data interrogation software package for structural health monitoring with a modular wireless sensing and processing platform. More specifically, this paper will address the need to take an integrated hardware/software approach to developing SHM solutions.« less

  7. Implementation of a High-Speed FPGA and DSP Based FFT Processor for Improving Strain Demodulation Performance in a Fiber-Optic-Based Sensing System

    NASA Technical Reports Server (NTRS)

    Farley, Douglas L.

    2005-01-01

    NASA's Aviation Safety and Security Program is pursuing research in on-board Structural Health Management (SHM) technologies for purposes of reducing or eliminating aircraft accidents due to system and component failures. Under this program, NASA Langley Research Center (LaRC) is developing a strain-based structural health-monitoring concept that incorporates a fiber optic-based measuring system for acquiring strain values. This fiber optic-based measuring system provides for the distribution of thousands of strain sensors embedded in a network of fiber optic cables. The resolution of strain value at each discrete sensor point requires a computationally demanding data reduction software process that, when hosted on a conventional processor, is not suitable for near real-time measurement. This report describes the development and integration of an alternative computing environment using dedicated computing hardware for performing the data reduction. Performance comparison between the existing and the hardware-based system is presented.

  8. Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1

    PubMed Central

    Kanehiro, Yuichi; Todo, Kagefumi; Negishi, Misaki; Fukuoka, Junji; Gan, Wenjian; Hikasa, Takuya; Kaga, Yoshiaki; Takemoto, Masayuki; Magari, Masaki; Li, Xialu; Manley, James L.; Ohmori, Hitoshi; Kanayama, Naoki

    2012-01-01

    Somatic hypermutation (SHM) of Ig variable region (IgV) genes requires both IgV transcription and the enzyme activation-induced cytidine deaminase (AID). Identification of a cofactor responsible for the fact that IgV genes are much more sensitive to AID-induced mutagenesis than other genes is a key question in immunology. Here, we describe an essential role for a splice isoform of the prototypical serine/arginine-rich (SR) protein SRSF1, termed SRSF1-3, in AID-induced SHM in a DT40 chicken B-cell line. Unexpectedly, we found that SHM does not occur in a DT40 line lacking SRSF1-3 (DT40-ASF), although it is readily detectable in parental DT40 cells. Strikingly, overexpression of AID in DT40-ASF cells led to a large increase in nonspecific (off-target) mutations. In contrast, introduction of SRSF1-3, but not SRSF1, into these cells specifically restored SHM without increasing off-target mutations. Furthermore, we found that SRSF1-3 binds preferentially to the IgV gene and inhibits processing of the Ig transcript, providing a mechanism by which SRSF1-3 makes the IgV gene available for AID-dependent SHM. SRSF1 not only acts as an essential splicing factor but also regulates diverse aspects of mRNA metabolism and maintains genome stability. Our findings, thus, define an unexpected and important role for SRSF1, particularly for its splice variant, in enabling AID to function specifically on its natural substrate during SHM. PMID:22232677

  9. Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1.

    PubMed

    Kanehiro, Yuichi; Todo, Kagefumi; Negishi, Misaki; Fukuoka, Junji; Gan, Wenjian; Hikasa, Takuya; Kaga, Yoshiaki; Takemoto, Masayuki; Magari, Masaki; Li, Xialu; Manley, James L; Ohmori, Hitoshi; Kanayama, Naoki

    2012-01-24

    Somatic hypermutation (SHM) of Ig variable region (IgV) genes requires both IgV transcription and the enzyme activation-induced cytidine deaminase (AID). Identification of a cofactor responsible for the fact that IgV genes are much more sensitive to AID-induced mutagenesis than other genes is a key question in immunology. Here, we describe an essential role for a splice isoform of the prototypical serine/arginine-rich (SR) protein SRSF1, termed SRSF1-3, in AID-induced SHM in a DT40 chicken B-cell line. Unexpectedly, we found that SHM does not occur in a DT40 line lacking SRSF1-3 (DT40-ASF), although it is readily detectable in parental DT40 cells. Strikingly, overexpression of AID in DT40-ASF cells led to a large increase in nonspecific (off-target) mutations. In contrast, introduction of SRSF1-3, but not SRSF1, into these cells specifically restored SHM without increasing off-target mutations. Furthermore, we found that SRSF1-3 binds preferentially to the IgV gene and inhibits processing of the Ig transcript, providing a mechanism by which SRSF1-3 makes the IgV gene available for AID-dependent SHM. SRSF1 not only acts as an essential splicing factor but also regulates diverse aspects of mRNA metabolism and maintains genome stability. Our findings, thus, define an unexpected and important role for SRSF1, particularly for its splice variant, in enabling AID to function specifically on its natural substrate during SHM.

  10. Integrating multiple immunogenetic data sources for feature extraction and mining somatic hypermutation patterns: the case of "towards analysis" in chronic lymphocytic leukaemia.

    PubMed

    Kavakiotis, Ioannis; Xochelli, Aliki; Agathangelidis, Andreas; Tsoumakas, Grigorios; Maglaveras, Nicos; Stamatopoulos, Kostas; Hadzidimitriou, Anastasia; Vlahavas, Ioannis; Chouvarda, Ioanna

    2016-06-06

    Somatic Hypermutation (SHM) refers to the introduction of mutations within rearranged V(D)J genes, a process that increases the diversity of Immunoglobulins (IGs). The analysis of SHM has offered critical insight into the physiology and pathology of B cells, leading to strong prognostication markers for clinical outcome in chronic lymphocytic leukaemia (CLL), the most frequent adult B-cell malignancy. In this paper we present a methodology for integrating multiple immunogenetic and clinocobiological data sources in order to extract features and create high quality datasets for SHM analysis in IG receptors of CLL patients. This dataset is used as the basis for a higher level integration procedure, inspired form social choice theory. This is applied in the Towards Analysis, our attempt to investigate the potential ontogenetic transformation of genes belonging to specific stereotyped CLL subsets towards other genes or gene families, through SHM. The data integration process, followed by feature extraction, resulted in the generation of a dataset containing information about mutations occurring through SHM. The Towards analysis performed on the integrated dataset applying voting techniques, revealed the distinct behaviour of subset #201 compared to other subsets, as regards SHM related movements among gene clans, both in allele-conserved and non-conserved gene areas. With respect to movement between genes, a high percentage movement towards pseudo genes was found in all CLL subsets. This data integration and feature extraction process can set the basis for exploratory analysis or a fully automated computational data mining approach on many as yet unanswered, clinically relevant biological questions.

  11. Development of regional earthquake early warning and structural health monitoring system and real-time ground motion forecasting using front-site waveform data (Invited)

    NASA Astrophysics Data System (ADS)

    Motosaka, M.

    2009-12-01

    This paper presents firstly, the development of an integrated regional earthquake early warning (EEW) system having on-line structural health monitoring (SHM) function, in Miyagi prefecture, Japan. The system makes it possible to provide more accurate, reliable and immediate earthquake information for society by combining the national (JMA/NIED) EEW system, based on advanced real-time communication technology. The author has planned to install the EEW/SHM system to the public buildings around Sendai, a million city of north-eastern Japan. The system has been so far implemented in two buildings; one is in Sendai, and the other in Oshika, a front site on the Pacific Ocean coast for the approaching Miyagi-ken Oki earthquake. The data from the front-site and the on-site are processed by the analysis system which was installed at the analysis center of Disaster Control Research Center, Tohoku University. The real-time earthquake information from JMA is also received at the analysis center. The utilization of the integrated EEW/SHM system is addressed together with future perspectives. Examples of the obtained data are also described including the amplitude depending dynamic characteristics of the building in Sendai before, during, and after the 2008/6/14 Iwate-Miyagi Nairiku Earthquake, together with the historical change of dynamic characteristics for 40 years. Secondary, this paper presents an advanced methodology based on Artificial Neural Networks (ANN) for forward forecasting of ground motion parameters, not only PGA, PGV, but also Spectral information before S-wave arrival using initial part of P-waveform at a front site. The estimated ground motion information can be used as warning alarm for earthquake damage reduction. The Fourier Amplitude Spectra (FAS) estimated before strong shaking with high accuracy can be used for advanced engineering applications, e.g. feed-forward structural control of a building of interest. The validity and applicability of the method have been verified by using observation data sets of the K-NET sites of 39 earthquakes occurred in Miyagi Oki area. The initial part of P waveform data at the Oshika site (MYG011) of K-NET were used as the front-site waveform data. The earthquake observation data for 35 earthquakes among the 39 earthquakes, as well as the positional-information and site repartition information, were used as training data to construct the ANN structure. The data set for the remaining 4 earthquakes were used as the test data in the blind prediction of PGA and PGV at the 4 sites, namely, Sendai (MYG013), Taiwa (MYG009), Shiogama (MYG012), and Ishinomaki (MYG010).

  12. Structural phylogenetic analysis of activation-induced deaminase function.

    PubMed

    Ichikawa, H Travis; Sowden, Mark P; Torelli, Andrew T; Bachl, Jürgen; Huang, Pinwei; Dance, Geoffrey S C; Marr, Shauna H; Robert, Jacques; Wedekind, Joseph E; Smith, Harold C; Bottaro, Andrea

    2006-07-01

    In mammals, activation-induced deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) of Ig genes. SHM and CSR activities require separate regions within AID. A chromosome region maintenance 1 (CRM1)-dependent nuclear export signal (NES) at the AID C terminus is necessary for CSR, and has been suggested to associate with CSR-specific cofactors. CSR appeared late in AID evolution, during the emergence of land vertebrates from bony fish, which only display SHM. Here, we show that AID from African clawed frog (Xenopus laevis), but not pufferfish (Takifugu rubripes), can induce CSR in AID-deficient mouse B cells, although both are catalytically active in bacteria and mammalian cell systems, albeit at decreased level. Like mammalian AID, Takifugu AID is actively exported from the cell nucleus by CRM1, and the Takifugu NES can substitute for the equivalent region in human AID, indicating that all the CSR-essential NES motif functions evolutionarily predated CSR activity. We also show that fusion of the Takifugu AID catalytic domain to the entire human noncatalytic domain restores activity in mammalian cells, suggesting that AID features mapping within the noncatalytic domain, but outside the NES, influence its function.

  13. Operational Testing of Satellite based Hydrological Model (SHM)

    NASA Astrophysics Data System (ADS)

    Gaur, Srishti; Paul, Pranesh Kumar; Singh, Rajendra; Mishra, Ashok; Gupta, Praveen Kumar; Singh, Raghavendra P.

    2017-04-01

    Incorporation of the concept of transposability in model testing is one of the prominent ways to check the credibility of a hydrological model. Successful testing ensures ability of hydrological models to deal with changing conditions, along with its extrapolation capacity. For a newly developed model, a number of contradictions arises regarding its applicability, therefore testing of credibility of model is essential to proficiently assess its strength and limitations. This concept emphasizes to perform 'Hierarchical Operational Testing' of Satellite based Hydrological Model (SHM), a newly developed surface water-groundwater coupled model, under PRACRITI-2 program initiated by Space Application Centre (SAC), Ahmedabad. SHM aims at sustainable water resources management using remote sensing data from Indian satellites. It consists of grid cells of 5km x 5km resolution and comprises of five modules namely: Surface Water (SW), Forest (F), Snow (S), Groundwater (GW) and Routing (ROU). SW module (functions in the grid cells with land cover other than forest and snow) deals with estimation of surface runoff, soil moisture and evapotranspiration by using NRCS-CN method, water balance and Hragreaves method, respectively. The hydrology of F module is dependent entirely on sub-surface processes and water balance is calculated based on it. GW module generates baseflow (depending on water table variation with the level of water in streams) using Boussinesq equation. ROU module is grounded on a cell-to-cell routing technique based on the principle of Time Variant Spatially Distributed Direct Runoff Hydrograph (SDDH) to route the generated runoff and baseflow by different modules up to the outlet. For this study Subarnarekha river basin, flood prone zone of eastern India, has been chosen for hierarchical operational testing scheme which includes tests under stationary as well as transitory conditions. For this the basin has been divided into three sub-basins using three flow gauging sites as reference, viz., Muri, Jamshedpur and Ghatshila. Individual model set-up has been prepared for these sub-basins and calibration and validation using Split-sample test, first level of operational testing scheme is in progress. Subsequently for geographic transposability, Proxy-basin test will be done using Muri and Jamshedpur as proxy basins. Climatic transposability will be tested for dry and wet years using Differential split-sample test. For incorporating both geographic and climatic transposability Proxy-basin differential split sample test will be used. For quantitative evaluation of SHM, during Split-sample test Nash-Sutcliffe efficiency (NSE), Coefficient of Determination (R R^2)) and Percent BIAS (PBIAS) are being used. However, for transposability, a productive approach involving these performance measures, i.e. NSE*R R^2)*PBIAS will be used to decide the best value of parameters. Keywords: SHM, credibility, operational testing, transposability.

  14. Probabilistic modeling of condition-based maintenance strategies and quantification of its benefits for airliners

    NASA Astrophysics Data System (ADS)

    Pattabhiraman, Sriram

    Airplane fuselage structures are designed with the concept of damage tolerance, wherein small damage are allowed to remain on the airplane, and damage that otherwise affect the safety of the structure are repaired. The damage critical to the safety of the fuselage are repaired by scheduling maintenance at pre-determined intervals. Scheduling maintenance is an interesting trade-off between damage tolerance and cost. Tolerance of larger damage would require less frequent maintenance and hence, a lower cost, to maintain a certain level of reliability. Alternatively, condition-based maintenance techniques have been developed using on-board sensors, which track damage continuously and request maintenance only when the damage size crosses a particular threshold. This effects a tolerance of larger damage than scheduled maintenance, leading to savings in cost. This work quantifies the savings of condition-based maintenance over scheduled maintenance. The work also quantifies converting the cost savings into weight savings. Structural health monitoring will need time to be able to establish itself as a stand-alone system for maintenance, due to concerns on its diagnosis accuracy and reliability. This work also investigates the effect of synchronizing structural health monitoring system with scheduled maintenance. This work uses on-board SHM equipment skip structural airframe maintenance (a subsect of scheduled maintenance), whenever deemed unnecessary while maintain a desired level of safety of structure. The work will also predict the necessary maintenance for a fleet of airplanes, based on the current damage status of the airplanes. The work also analyses the possibility of false alarm, wherein maintenance is being requested with no critical damage on the airplane. The work use SHM as a tool to identify lemons in a fleet of airplanes. Lemons are those airplanes that would warrant more maintenance trips than the average behavior of the fleet.

  15. Implementation of civionics in a second generation steel-free bridge deck

    NASA Astrophysics Data System (ADS)

    Klowak, Chad; Rivera, Evangeline; Mufti, Aftab

    2005-05-01

    As the design and construction of civil structures continue to evolve, it is becoming imperative that these structures be monitored for their health. In order to meet this need, the discipline of Civionics has emerged. Civionics is a new term coined from Civil-Electronics, which is derived from the application of electronics to civil structures. It is similar to the term Avionics, which is used in the aerospace industry. If structural health monitoring is to become part of civil structural engineering, it should include Civionics. It involves the application of electronics to civil structures and aims to assist engineers in realizing the full benefits of structural health monitoring (SHM). In past SHM field applications, the main reason for the failure of a sensor was not the installation of the sensor itself but the egress of the sensor cables. Often, the cables were not handled and protected correctly. For SHM to be successful, specifications must be written on the entire process, beginning with system design and concluding with data collection, interpretation, and management. Civionics specifications include the technical requirements for a SHM system which encompasses fibre optic sensors, cables, conduits, junction boxes and the control room. A specification for data collection and storage is currently being developed as well. In the spring of 2004 research engineers at the University of Manitoba constructed a full-scale second generation steel free bridge deck. The bridge deck is the first of its kind to fully incorporate a complete civionics structural health monitoring system to monitor the deck's behaviour during destructive testing. Throughout the construction of the bridge deck, the entire installation of the civionics system was carried out by research engineers simulating an actual implementation of such a system in a large scale construction environment. One major concern that consulting engineers have raised is the impact that a civionics system that uses conduit, junction boxes, and other electrical ancillary protection, will have when embedded and installed externally on full-scale infrastructure. The full-scale destructive testing of a second generation steel-free bridge deck using a civionics system designed and implemented following guidelines in a civioncs specification manual at the University of Manitoba will provide engineers with the information necessary to address the constructability and structural integrity issues. Civioncs combined with structural health monitoring will provide engineers with feedback necessary to aid in optimizing design techniques and understanding our infrastructures performance, behaviour and state of condition.

  16. Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID

    PubMed Central

    Kodgire, Prashant; Mukkawar, Priyanka; Ratnam, Sarayu; Martin, Terence E.

    2013-01-01

    Somatic hypermutation (SHM) of Ig genes is initiated by the activation-induced cytidine deaminase (AID), and requires target gene transcription. We previously proposed that AID may associate with the RNA polymerase II (Pol). Here, to determine aspects of the transcription process required for SHM, we knocked-in a transcription terminator into an Ig gene variable region in DT40 chicken B cell line. We found that the human β-globin terminator was an efficient inhibitor of downstream transcription in these cells. The terminator reduced mutations downstream of the poly(A) signal, suggesting that the process of transcription is essential for efficient SHM and that AID has better access to its target when Pol is in the elongating rather than terminating mode. Mutations upstream of the poly(A) site were almost doubled in the active terminator clones compared with an inactivated terminator, and this region showed more single-stranded DNA, indicating that Pol pausing assists SHM. Moreover, the nontranscribed DNA strand was the preferred SHM target upstream of the active terminator. Pol pausing during poly(A) site recognition may facilitate persistence of negative supercoils, exposing the coding single strand and possibly allowing the nascent RNA intermittent reannealing with the template strand, for prolonged access of AID. PMID:23752228

  17. Development of Structural Health Management Technology for Aerospace Vehicles

    NASA Technical Reports Server (NTRS)

    Prosser, W. H.

    2003-01-01

    As part of the overall goal of developing Integrated Vehicle Health Management (IVHM) systems for aerospace vehicles, NASA has focused considerable resources on the development of technologies for Structural Health Management (SHM). The motivations for these efforts are to increase the safety and reliability of aerospace structural systems, while at the same time decreasing operating and maintenance costs. Research and development of SHM technologies has been supported under a variety of programs for both aircraft and spacecraft including the Space Launch Initiative, X-33, Next Generation Launch Technology, and Aviation Safety Program. The major focus of much of the research to date has been on the development and testing of sensor technologies. A wide range of sensor technologies are under consideration including fiber-optic sensors, active and passive acoustic sensors, electromagnetic sensors, wireless sensing systems, MEMS, and nanosensors. Because of their numerous advantages for aerospace applications, most notably being extremely light weight, fiber-optic sensors are one of the leading candidates and have received considerable attention.

  18. A wireless data acquisition system for acoustic emission testing

    NASA Astrophysics Data System (ADS)

    Zimmerman, A. T.; Lynch, J. P.

    2013-01-01

    As structural health monitoring (SHM) systems have seen increased demand due to lower costs and greater capabilities, wireless technologies have emerged that enable the dense distribution of transducers and the distributed processing of sensor data. In parallel, ultrasonic techniques such as acoustic emission (AE) testing have become increasingly popular in the non-destructive evaluation of materials and structures. These techniques, which involve the analysis of frequency content between 1 kHz and 1 MHz, have proven effective in detecting the onset of cracking and other early-stage failure in active structures such as airplanes in flight. However, these techniques typically involve the use of expensive and bulky monitoring equipment capable of accurately sensing AE signals at sampling rates greater than 1 million samples per second. In this paper, a wireless data acquisition system is presented that is capable of collecting, storing, and processing AE data at rates of up to 20 MHz. Processed results can then be wirelessly transmitted in real-time, creating a system that enables the use of ultrasonic techniques in large-scale SHM systems.

  19. Dissolved and labile concentrations of Cd, Cu, Pb, and Zn in the South Fork Coeur d'Alene River, Idaho: Comparisons among chemical equilibrium models and implications for biotic ligand models

    USGS Publications Warehouse

    Balistrieri, L.S.; Blank, R.G.

    2008-01-01

    In order to evaluate thermodynamic speciation calculations inherent in biotic ligand models, the speciation of dissolved Cd, Cu, Pb, and Zn in aquatic systems influenced by historical mining activities is examined using equilibrium computer models and the diffusive gradients in thin films (DGT) technique. Several metal/organic-matter complexation models, including WHAM VI, NICA-Donnan, and Stockholm Humic model (SHM), are used in combination with inorganic speciation models to calculate the thermodynamic speciation of dissolved metals and concentrations of metal associated with biotic ligands (e.g., fish gills). Maximum dynamic metal concentrations, determined from total dissolved metal concentrations and thermodynamic speciation calculations, are compared with labile metal concentrations measured by DGT to assess which metal/organic-matter complexation model best describes metal speciation and, thereby, biotic ligand speciation, in the studied systems. Results indicate that the choice of model that defines metal/organic-matter interactions does not affect calculated concentrations of Cd and Zn associated with biotic ligands for geochemical conditions in the study area, whereas concentrations of Cu and Pb associated with biotic ligands depend on whether the speciation calculations use WHAM VI, NICA-Donnan, or SHM. Agreement between labile metal concentrations and dynamic metal concentrations occurs when WHAM VI is used to calculate Cu speciation and SHM is used to calculate Pb speciation. Additional work in systems that contain wide ranges in concentrations of multiple metals should incorporate analytical speciation methods, such as DGT, to constrain the speciation component of biotic ligand models. ?? 2008 Elsevier Ltd.

  20. Monitoring long-term in-situs behavior of installed fiber reinforced polymer.

    DOT National Transportation Integrated Search

    2009-06-01

    The objective of this report is to provide information on state of the art in structural health : monitoring (SHM) and its application to bridges. The most recent trends in SHM with regard to : fiber reinforced polymer (FRP) composites are discussed....

  1. Data analysis and detection methods for on-line health monitoring of bridge structures

    DOT National Transportation Integrated Search

    2002-06-01

    Developing an efficient structural health monitoring (SHM) technique is important for reducing potential hazards posed : to the public by damaged civil structures. The ultimate goal of applying SHM is to real-time detect, localize, and quantify : the...

  2. Civionics specifications for fiber optic sensors for structural health monitoring

    NASA Astrophysics Data System (ADS)

    Rivera, Evangeline; Mufti, Aftab A.; Thomson, Douglas J.

    2004-07-01

    As the design and construction of civil structures continue to evolve, it is becoming imperative that these structures be monitored for their health. In order to meet this need, the discipline of Civionics has emerged. It involves the applications to civil structures and aims to assist engineers in realizing the full benefits of structural health monitoring (SHM). Therefore, the goal of the specification outlined in this work is to ensure that correct installation and operating of fiber optic sensors, such as bridges, will be discussed that motivated the writing of these specifications. The main reason for the failure of FOS based monitoring systems can be traced directly to the installation of the fiber sensor itself. Therefore, by creating a standard procedure for SHM, several ambiguities are eliminated such as fiber sensor specifications and the types of cables required. As a result, these specifications will help ensure that the sensors will survive the installation process and eventually prove their value over years of monitoring the health of the structure. The Civionics FOS specifications include the requirements for fiber sensors, specifically Bragg grating sensors, and their corresponding readout unit. It also includes specifications on the cables, conduits, junction boxes, cable termination and the environmental.

  3. Challenges of NDE simulation tool validation, optimization, and utilization for composites

    NASA Astrophysics Data System (ADS)

    Leckey, Cara A. C.; Seebo, Jeffrey P.; Juarez, Peter

    2016-02-01

    Rapid, realistic nondestructive evaluation (NDE) simulation tools can aid in inspection optimization and prediction of inspectability for advanced aerospace materials and designs. NDE simulation tools may someday aid in the design and certification of aerospace components; potentially shortening the time from material development to implementation by industry and government. Furthermore, ultrasound modeling and simulation are expected to play a significant future role in validating the capabilities and limitations of guided wave based structural health monitoring (SHM) systems. The current state-of-the-art in ultrasonic NDE/SHM simulation is still far from the goal of rapidly simulating damage detection techniques for large scale, complex geometry composite components/vehicles containing realistic damage types. Ongoing work at NASA Langley Research Center is focused on advanced ultrasonic simulation tool development. This paper discusses challenges of simulation tool validation, optimization, and utilization for composites. Ongoing simulation tool development work is described along with examples of simulation validation and optimization challenges that are more broadly applicable to all NDE simulation tools. The paper will also discuss examples of simulation tool utilization at NASA to develop new damage characterization methods for composites, and associated challenges in experimentally validating those methods.

  4. Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age.

    PubMed

    de Jong, Britt G; IJspeert, Hanna; Marques, Lemelinda; van der Burg, Mirjam; van Dongen, Jacques Jm; Loos, Bruno G; van Zelm, Menno C

    2017-10-01

    The mechanisms involved in sequential immunoglobulin G (IgG) class switching are still largely unknown. Sequential IG class switching is linked to higher levels of somatic hypermutation (SHM) in vivo, but it remains unclear if these are generated temporally during an immune response or upon activation in a secondary response. We here aimed to uncouple these processes and to distinguish memory B cells from primary and secondary immune responses. SHM levels and IgG subclasses were studied with 454 pyrosequencing on blood mononuclear cells from young children and adults as models for primary and secondary immunological memory. Additional sequencing and detailed immunophenotyping with IgG subclass-specific antibodies was performed on purified IgG + memory B-cell subsets. In both children and adults, SHM levels were higher in transcripts involving more downstream-located IGHG genes (esp. IGHG2 and IGHG4). In adults, SHM levels were significantly higher than in children, and downstream IGHG genes were more frequently utilized. This was associated with increased frequencies of CD27 + IgG + memory B cells, which contained higher levels of SHM, more IGHG2 usage, and higher expression levels of activation markers than CD27 - IgG + memory B cells. We conclude that secondary immunological memory accumulates with age and these memory B cells express CD27, high levels of activation markers, and carry high SHM levels and frequent usage of IGHG2. These new insights contribute to our understanding of sequential IgG subclass switching and show a potential relevance of using serum IgG2 levels or numbers of IgG2-expressing B cells as markers for efficient generation of memory responses.

  5. Enhanced health monitoring of fibrous composites with aligned carbon nanotube networks and electrical impedance tomography

    NASA Astrophysics Data System (ADS)

    Tallman, T.; Semperlotti, F.; Wang, K. W.

    2012-04-01

    The high strength to weight ratio of fibrous composites such as glass-fiber reinforced polymers (GFRP) makes them prominent structural materials. However, their laminar nature is susceptible to delamination failure the onset of which traditional structural health monitoring (SHM) techniques cannot reliably and accurately detect. Carbon nano-tubes (CNT) have been recently used to tailor the electrical conductivity of polymer based materials that otherwise behave as insulators. The occurrence of damage in the polymer matrix produces localized changes in conductivity which can be tracked using electrical impedance tomography (EIT). This paper explores combining advances in composite manufacturing with EIT to develop a SHM technique that exploits anisotropic conductance monitoring for enhanced delamination and matrix crack detection.

  6. Monitoring of bolted joints using piezoelectric active-sensing for aerospace applications

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Park, Gyuhae; Farrar, Charles R; Park, Chan - Yik

    2010-01-01

    This paper is a report of an initial investigation into tracking and monitoring the integrity of bolted joints using piezoelectric active-sensors. The target application of this study is a fitting lug assembly of unmanned aerial vehicles (UAVs), where a composite wing is mounted to a UAV fuselage. The SHM methods deployed in this study are impedance-based SHM techniques, time-series analysis, and high-frequency response functions measured by piezoelectric active-sensors. Different types of simulated damage are introduced into the structure, and the capability of each technique is examined and compared. Additional considerations encountered in this initial investigation are made to guide furthermore » thorough research required for the successful field deployment of this technology.« less

  7. Performance Analysis of Ivshmem for High-Performance Computing in Virtual Machines

    NASA Astrophysics Data System (ADS)

    Ivanovic, Pavle; Richter, Harald

    2018-01-01

    High-Performance computing (HPC) is rarely accomplished via virtual machines (VMs). In this paper, we present a remake of ivshmem which can change this. Ivshmem was a shared memory (SHM) between virtual machines on the same server, with SHM-access synchronization included, until about 5 years ago when newer versions of Linux and its virtualization library libvirt evolved. We restored that SHM-access synchronization feature because it is indispensable for HPC and made ivshmem runnable with contemporary versions of Linux, libvirt, KVM, QEMU and especially MPICH, which is an implementation of MPI - the standard HPC communication library. Additionally, MPICH was transparently modified by us to get ivshmem included, resulting in a three to ten times performance improvement compared to TCP/IP. Furthermore, we have transparently replaced MPI_PUT, a single-side MPICH communication mechanism, by an own MPI_PUT wrapper. As a result, our ivshmem even surpasses non-virtualized SHM data transfers for block lengths greater than 512 KBytes, showing the benefits of virtualization. All improvements were possible without using SR-IOV.

  8. Development of a fiber-guided laser ultrasonic system resilient to high temperature and gamma radiation for nuclear power plant pipe monitoring

    NASA Astrophysics Data System (ADS)

    Yang, Jinyeol; Lee, Hyeonseok; Lim, Hyung Jin; Kim, Nakhyeon; Yeo, Hwasoo; Sohn, Hoon

    2013-08-01

    This study develops an embeddable optical fiber-guided laser ultrasonic system for structural health monitoring (SHM) of pipelines exposed to high temperature and gamma radiation inside nuclear power plants (NPPs). Recently, noncontact laser ultrasonics is gaining popularity among the SHM community because of its advantageous characteristics such as (a) scanning capability, (b) immunity against electromagnetic interference (EMI) and (c) applicability to high-temperature surfaces. However, its application to NPP pipelines has been hampered because pipes inside NPPs are often covered by insulators and/or target surfaces are not easily accessible. To overcome this problem, this study designs embeddable optical fibers and fixtures so that laser beams used for ultrasonic inspection can be transmitted between the laser sources and the target pipe. For guided-wave generation, an Nd:Yag pulsed laser coupled with an optical fiber is used. A high-power pulsed laser beam is guided through the optical fiber onto a target structure. Based on the principle of laser interferometry, the corresponding response is measured using a different type of laser beam guided by another optical fiber. All devices are especially designed to sustain high temperature and gamma radiation. The robustness/resilience of the proposed measurement system installed on a stainless steel pipe specimen has been experimentally verified by exposing the specimen to high temperature of up to 350 °C and optical fibers to gamma radiation of up to 125 kGy (20 kGy h-1).

  9. Structural health monitoring technology for bolted carbon-carbon thermal protection panels

    NASA Astrophysics Data System (ADS)

    Yang, Jinkyu

    2005-12-01

    The research in this dissertation is motivated by the need for reliable inspection technologies for the detection of bolt loosening in Carbon-Carbon (C-C) Thermal Protection System (TPS) panels on Space Operation Vehicles (SOV) using minimal human intervention. A concept demonstrator of the Structural Health Monitoring (SHM) system was developed to autonomously detect the degradation of the mechanical integrity of the standoff C-C TPS panels. This system assesses the torque levels of the loosened bolts in the C-C TPS panel, as well as identifies the location of those bolts accordingly. During the course of building the proposed SHM prototype, efforts have been focused primarily on developing a trustworthy diagnostic scheme and a responsive sensor suite. Based on the microcontact conditions and damping phenomena of ultrasonic waves across the bolted joints, an Attenuation-based Diagnostic Method was proposed to assess the fastener integrity by observing the attenuation patterns of the resultant sensor signals. Parametric model studies and prototype testing validated the theoretical explanation of the attenuation-based method. Once the diagnostic scheme was determined, the implementation of a sensor suite was the next step. A new PZT-embedded sensor washer was developed to enhance remote sensing capability and achieve sufficient sensitivity by guiding diagnostic waves primarily through the inspection areas. The sensor-embedded washers replace the existing washers to constitute the sensor network, as well as to avoid jeopardizing the integrity of the original fastener components. After sensor design evolution and appropriate algorithm development, verification tests were conducted using a shaker and a full-scale oven, which simulated the acoustic and thermal environments during the re-entry process, respectively. The test results revealed that the proposed system successfully identifies the loss of the preload for the bolted joints that were loosened. The sensors were also found to be durable under the cyclic mechanical and thermal loads without major failures.

  10. On switching response surface models, with applications to the structural health monitoring of bridges

    NASA Astrophysics Data System (ADS)

    Worden, K.; Cross, E. J.

    2018-01-01

    Structural Health Monitoring (SHM) is the engineering discipline of diagnosing damage and estimating safe remaining life for structures and systems. Often, SHM is accomplished by detecting changes in measured quantities from the structure of interest; if there are no competing explanations for the changes, one infers that they are the result of damage. If the structure of interest is subject to changes in its environmental or operational conditions, one must understand the effects of these changes in order that one does not falsely claim that damage has occurred when changes in measured quantities are observed. This problem - the problem of confounding influences - is particularly pressing for civil infrastructure where the given structure is usually openly exposed to the weather and may be subject to strongly varying operational conditions. One approach to understanding confounding influences is to construct a data-based response surface model that can represent measurement variations as a function of environmental and operational variables. The models can then be used to remove environmental and operational variations so that change detection algorithms signal the occurrence of damage alone. The current paper is concerned with such response surface models in the case of SHM of bridges. In particular, classes of response surface models that can switch discontinuously between regimes are discussed. Recently, it has been shown that Gaussian Process (GP) models are an effective means of developing response surface or surrogate models. However, the GP approach runs into difficulties if changes in the latent variables cause the structure of interest to abruptly switch between regimes. A good example here, which is well known in the SHM literature, is given by the Z24 Bridge in Switzerland which completely changed its dynamical behaviour when it cooled below zero degrees Celsius as the asphalt of the deck stiffened. The solution proposed here is to adopt the recently-proposed Treed Gaussian Process (TGP) model as an alternative. The approach is illustrated here on the Z24 bridge and also on data from the Tamar Bridge in the UK which shows marked switching behaviour in certain of its dynamical characteristics when its ambient wind conditions change. It is shown that treed GPs provide an effective approach to response surface modelling and that in the Tamar case, a linear model is in fact sufficient to solve the problem.

  11. Automation of data collection for PWAS-based structural health monitoring

    NASA Astrophysics Data System (ADS)

    Liu, Weiping; Giurgiutiu, Victor

    2005-05-01

    Crack detection with piezoelectric wafer active sensors (PWAS) is emerging as an effective and powerful technique in structural health monitoring (SHM). Because of the piezoelectric properties of the PWAS, they act as both transmitters and receivers of guided Lamb waves for such applications. With arrays of PWAS attached to the structure, excitation signals are sent to one of the PWAS and wave signals from the structure are received at all the PWAS. The signals are analyzed to detect the position of cracks. One important issue associated with the PWAS-assisted SHM is the connectivity between the PWAS arrays and the measurement instruments. An automatic signal collection unit is necessary to send the excitation signals to PWAS and acquire the response signal from another PWAS. Such a program-controlled switching unit can quickly and precisely execute the data collection in a way which is more efficient and reliable than the manual switching operations. In this paper, we present an innovative design of a LabVIEW controlled automatic signal collection unit (ASCU) for PWAS-assisted SHM. The hardware circuit construction and the control LabVIEW program are discussed. As a conduit between the phase array of PWAS and the signal instruments (signal generators, oscilloscopes etc.), the ASCU provides a convenient way to switch excitation and echo signals automatically to the selected PWAS transducers with the help of GUI in the LabVIEW control program. The control program is easy to implement and can be integrated into an upper level program that executes the whole task of signal acquisition and analysis. Because of the concise design of the hardware, the ASCU concept of the auto signal switch has been extended to other application cases such as the electromechanical (E/M) impedance measurement for SHM.

  12. Using "Tracker" to Prove the Simple Harmonic Motion Equation

    ERIC Educational Resources Information Center

    Kinchin, John

    2016-01-01

    Simple harmonic motion (SHM) is a common topic for many students to study. Using the free, though versatile, motion tracking software; "Tracker", we can extend the students experience and show that the general equation for SHM does lead to the correct period of a simple pendulum.

  13. Ecological and physical barriers shape genetic structure of the Alpine porcini (Boletus reticuloceps).

    PubMed

    Feng, Bang; Liu, Jian Wei; Xu, Jianping; Zhao, Kuan; Ge, Zai Wei; Yang, Zhu L

    2017-04-01

    The Alpine porcini, Boletus reticuloceps, is an ectomycorrhizal mushroom distributed in subalpine areas of Southwest China, central China, and Taiwan Island. This distribution pattern makes it an ideal organism to infer how ectomycorrhizal fungi have reacted to historical tectonic and climatic changes, and to illustrate the mechanism for the disjunction of organisms between Southwest China and Taiwan. In this study, we explored the phylogeographic pattern of B. reticuloceps by microsatellite genotyping, DNA sequencing, ecological factor analysis, and species distribution modeling. Three genetic groups from the East Himalayas (EH), northern Hengduan Mountains (NHM), and southern Hengduan Mountains (SHM), were identified. The earlier divergent SHM group is found under Abies in moister environments, whereas the EH and NHM groups, which are physically separated by the Mekong-Salween Divide, are found mainly under Picea in drier environments. Samples from Taiwan showed a close relationship with the SHM group. High mountains did not form dispersal barriers among populations in each of the EH, NHM, and SHM groups, probably due to the relatively weak host specificity of B. reticuloceps. Our study indicated that ecological heterogeneity could have contributed to the divergence between the SHM and the NHM-EH groups, while physical barriers could have led to the divergence of the NHM and the EH groups. Dispersal into Taiwan via Central China during the Quaternary glaciations is likely to have shaped its disjunct distribution.

  14. Structural health management of aerospace hotspots under fatigue loading

    NASA Astrophysics Data System (ADS)

    Soni, Sunilkumar

    Sustainability and life-cycle assessments of aerospace systems, such as aircraft structures and propulsion systems, represent growing challenges in engineering. Hence, there has been an increasing demand in using structural health monitoring (SHM) techniques for continuous monitoring of these systems in an effort to improve safety and reduce maintenance costs. The current research is part of an ongoing multidisciplinary effort to develop a robust SHM framework resulting in improved models for damage-state awareness and life prediction, and enhancing capability of future aircraft systems. Lug joints, a typical structural hotspot, were chosen as the test article for the current study. The thesis focuses on integrated SHM techniques for damage detection and characterization in lug joints. Piezoelectric wafer sensors (PZTs) are used to generate guided Lamb waves as they can be easily used for onboard applications. Sensor placement in certain regions of a structural component is not feasible due to the inaccessibility of the area to be monitored. Therefore, a virtual sensing concept is introduced to acquire sensor data from finite element (FE) models. A full three dimensional FE analysis of lug joints with piezoelectric transducers, accounting for piezoelectrical-mechanical coupling, was performed in Abaqus and the sensor signals were simulated. These modeled sensors are called virtual sensors. A combination of real data from PZTs and virtual sensing data from FE analysis is used to monitor and detect fatigue damage in aluminum lug joints. Experiments were conducted on lug joints under fatigue loads and sensor signals collected were used to validate the simulated sensor response. An optimal sensor placement methodology for lug joints is developed based on a detection theory framework to maximize the detection rate and minimize the false alarm rate. The placement technique is such that the sensor features can be directly correlated to damage. The technique accounts for a number of factors, such as actuation frequency and strength, minimum damage size, damage detection scheme, material damping, signal to noise ratio and sensing radius. Advanced information processing methodologies are discussed for damage diagnosis. A new, instantaneous approach for damage detection, localization and quantification is proposed for applications to practical problems associated with changes in reference states under different environmental and operational conditions. Such an approach improves feature extraction for state awareness, resulting in robust life prediction capabilities.

  15. Frequency selection for coda wave interferometry in concrete structures.

    PubMed

    Fröjd, Patrik; Ulriksen, Peter

    2017-09-01

    This study contributes to the establishment of frequency recommendations for use in coda wave interferometry structural health monitoring (SHM) systems for concrete structures. To this end, codas with widely different central frequencies were used to detect boreholes with different diameters in a large concrete floor slab, and to track increasing damage in a small concrete beam subjected to bending loads. SHM results were obtained for damage that can be simulated by drilled holes on the scale of a few mm or microcracks due to bending. These results suggest that signals in the range of 50-150kHz are suitable in large concrete structures where it is necessary to account for the high attenuation of high-frequency signals. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  16. Structural Health Monitoring of a Composite Panel Based on PZT Sensors and a Transfer Impedance Framework.

    PubMed

    Dziendzikowski, Michal; Niedbala, Patryk; Kurnyta, Artur; Kowalczyk, Kamil; Dragan, Krzysztof

    2018-05-11

    One of the ideas for development of Structural Health Monitoring (SHM) systems is based on excitation of elastic waves by a network of PZT piezoelectric transducers integrated with the structure. In the paper, a variant of the so-called Transfer Impedance (TI) approach to SHM is followed. Signal characteristics, called the Damage Indices (DIs), were proposed for data presentation and analysis. The idea underlying the definition of DIs was to maintain most of the information carried by the voltage induced on PZT sensors by elastic waves. In particular, the DIs proposed in the paper should be sensitive to all types of damage which can influence the amplitude or the phase of the voltage induced on the sensor. Properties of the proposed DIs were investigated experimentally using a GFRP composite panel equipped with PZT networks attached to its surface and embedded into its internal structure. Repeatability and stability of DI indications under controlled conditions were verified in tests. Also, some performance indicators for surface-attached and structure-embedded sensors were obtained. The DIs' behavior was dependent mostly on the presence of a simulated damage in the structure. Anisotropy of mechanical properties of the specimen, geometrical properties of PZT network as well as, to some extent, the technology of sensor integration with the structure were irrelevant for damage indication. This property enables the method to be used for damage detection and classification.

  17. Development of lightweight structural health monitoring systems for aerospace applications

    NASA Astrophysics Data System (ADS)

    Pearson, Matthew

    This thesis investigates the development of structural health monitoring systems (SHM) for aerospace applications. The work focuses on each aspect of a SHM system covering novel transducer technologies and damage detection techniques to detect and locate damage in metallic and composite structures. Secondly the potential of energy harvesting and power arrangement methodologies to provide a stable power source is assessed. Finally culminating in the realisation of smart SHM structures. 1. Transducer Technology A thorough experimental study of low profile, low weight novel transducers not normally used for acoustic emission (AE) and acousto-ultrasonics (AU) damage detection was conducted. This included assessment of their performance when exposed to aircraft environments and feasibility of embedding these transducers in composites specimens in order to realise smart structures. 2. Damage Detection An extensive experimental programme into damage detection utilising AE and AU were conducted in both composites and metallic structures. These techniques were used to assess different damage mechanism within these materials. The same transducers were used for novel AE location techniques coupled with AU similarity assessment to successfully detect and locate damage in a variety of structures. 3. Energy Harvesting and Power Management Experimental investigations and numerical simulations were undertaken to assess the power generation levels of piezoelectric and thermoelectric generators for typical vibration and temperature differentials which exist in the aerospace environment. Furthermore a power management system was assessed to demonstrate the ability of the system to take the varying nature of the input power and condition it to a stable power source for a system. 4. Smart Structures The research conducted is brought together into a smart carbon fibre wing showcasing the novel embedded transducers for AE and AU damage detection and location, as well as vibration energy harvesting. A study into impact damage detection using the techniques showed the successful detection and location of damage. Also the feasibility of the embedded transducers for power generation was assessed..

  18. Development and Application of a Structural Health Monitoring System Based on Wireless Smart Aggregates

    PubMed Central

    Ma, Haoyan; Li, Peng; Song, Gangbing; Wu, Jianxin

    2017-01-01

    Structural health monitoring (SHM) systems can improve the safety and reliability of structures, reduce maintenance costs, and extend service life. Research on concrete SHMs using piezoelectric-based smart aggregates have reached great achievements. However, the newly developed techniques have not been widely applied in practical engineering, largely due to the wiring problems associated with large-scale structural health monitoring. The cumbersome wiring requires much material and labor work, and more importantly, the associated maintenance work is also very heavy. Targeting a practical large scale concrete crack detection (CCD) application, a smart aggregates-based wireless sensor network system is proposed for the CCD application. The developed CCD system uses Zigbee 802.15.4 protocols, and is able to perform dynamic stress monitoring, structural impact capturing, and internal crack detection. The system has been experimentally validated, and the experimental results demonstrated the effectiveness of the proposed system. This work provides important support for practical CCD applications using wireless smart aggregates. PMID:28714927

  19. Development and Application of a Structural Health Monitoring System Based on Wireless Smart Aggregates.

    PubMed

    Yan, Shi; Ma, Haoyan; Li, Peng; Song, Gangbing; Wu, Jianxin

    2017-07-17

    Structural health monitoring (SHM) systems can improve the safety and reliability of structures, reduce maintenance costs, and extend service life. Research on concrete SHMs using piezoelectric-based smart aggregates have reached great achievements. However, the newly developed techniques have not been widely applied in practical engineering, largely due to the wiring problems associated with large-scale structural health monitoring. The cumbersome wiring requires much material and labor work, and more importantly, the associated maintenance work is also very heavy. Targeting a practical large scale concrete crack detection (CCD) application, a smart aggregates-based wireless sensor network system is proposed for the CCD application. The developed CCD system uses Zigbee 802.15.4 protocols, and is able to perform dynamic stress monitoring, structural impact capturing, and internal crack detection. The system has been experimentally validated, and the experimental results demonstrated the effectiveness of the proposed system. This work provides important support for practical CCD applications using wireless smart aggregates.

  20. Understanding the Damped SHM without ODEs

    ERIC Educational Resources Information Center

    Ng, Chiu-king

    2016-01-01

    Instead of solving ordinary differential equations (ODEs), the damped simple harmonic motion (SHM) is surveyed qualitatively from basic mechanics and quantitatively by the instrumentality of a graph of velocity against displacement. In this way, the condition b ? [square root]4mk for the occurrence of the non-oscillating critical damping and…

  1. Course Modules on Structural Health Monitoring with Smart Materials

    ERIC Educational Resources Information Center

    Shih, Hui-Ru; Walters, Wilbur L.; Zheng, Wei; Everett, Jessica

    2009-01-01

    Structural Health Monitoring (SHM) is an emerging technology that has multiple applications. SHM emerged from the wide field of smart structures, and it also encompasses disciplines such as structural dynamics, materials and structures, nondestructive testing, sensors and actuators, data acquisition, signal processing, and possibly much more. To…

  2. Crack propagation analysis using acoustic emission sensors for structural health monitoring systems.

    PubMed

    Kral, Zachary; Horn, Walter; Steck, James

    2013-01-01

    Aerospace systems are expected to remain in service well beyond their designed life. Consequently, maintenance is an important issue. A novel method of implementing artificial neural networks and acoustic emission sensors to form a structural health monitoring (SHM) system for aerospace inspection routines was the focus of this research. Simple structural elements, consisting of flat aluminum plates of AL 2024-T3, were subjected to increasing static tensile loading. As the loading increased, designed cracks extended in length, releasing strain waves in the process. Strain wave signals, measured by acoustic emission sensors, were further analyzed in post-processing by artificial neural networks (ANN). Several experiments were performed to determine the severity and location of the crack extensions in the structure. ANNs were trained on a portion of the data acquired by the sensors and the ANNs were then validated with the remaining data. The combination of a system of acoustic emission sensors, and an ANN could determine crack extension accurately. The difference between predicted and actual crack extensions was determined to be between 0.004 in. and 0.015 in. with 95% confidence. These ANNs, coupled with acoustic emission sensors, showed promise for the creation of an SHM system for aerospace systems.

  3. A regime-switching cointegration approach for removing environmental and operational variations in structural health monitoring

    NASA Astrophysics Data System (ADS)

    Shi, Haichen; Worden, Keith; Cross, Elizabeth J.

    2018-03-01

    Cointegration is now extensively used to model the long term common trends among economic variables in the field of econometrics. Recently, cointegration has been successfully implemented in the context of structural health monitoring (SHM), where it has been used to remove the confounding influences of environmental and operational variations (EOVs) that can often mask the signature of structural damage. However, restrained by its linear nature, the conventional cointegration approach has limited power in modelling systems where measurands are nonlinearly related; this occurs, for example, in the benchmark study of the Z24 Bridge, where nonlinear relationships between natural frequencies were induced during a period of very cold temperatures. To allow the removal of EOVs from SHM data with nonlinear relationships like this, this paper extends the well-established cointegration method to a nonlinear context, which is to allow a breakpoint in the cointegrating vector. In a novel approach, the augmented Dickey-Fuller (ADF) statistic is used to find which position is most appropriate for inserting a breakpoint, the Johansen procedure is then utilised for the estimation of cointegrating vectors. The proposed approach is examined with a simulated case and real SHM data from the Z24 Bridge, demonstrating that the EOVs can be neatly eliminated.

  4. SHM reliability and implementation - A personal military aviation perspective

    NASA Astrophysics Data System (ADS)

    Lindgren, Eric A.

    2016-02-01

    Structural Health Monitoring has been proposed as a solution to address the needs of military aviation to reduce the time and cost to perform nondestructive inspections. While the potential to realize significant benefits exist, there are considerations that have to be addressed before such systems can be integrated into military platforms. Some considerations are pervasive to all aviation, such as how to assess the reliability and reproducible capability of these systems. However, there are other challenges unique to military aviation that must be overcome before these types of systems can be used. This presentation and paper are intended as a complement to the review of the outcome of the SAE G-11 SHM committee special workshop on SHM reliability in April of 2015. It will address challenges unique to military aviation that stem from different approaches to managing structural integrity (i.e. safety), frequency of use, design differences, various maintenance practices, and additional descriptions addressing differences in the execution of inspections. The objective of this presentation is to improve the awareness of the research and development community to the different and unique requirements found in military aviation, including the differences between countries, services, and aircraft type. This information should assist the research and development community in identifying and attacking key challenges. It is not intended to be comprehensive overview of all stakeholders' perspectives, but to serve as a launch point for additional discussion and exploration of opportunities to realize the potential of Structural Health Monitoring to assist in the management of military aviation assets. The views expressed in this publication are those of the author and do not reflect the official policy or position of the United States Air Force, Department of Defense, or the United States Government.

  5. Benchmarking of Computational Models for NDE and SHM of Composites

    NASA Technical Reports Server (NTRS)

    Wheeler, Kevin; Leckey, Cara; Hafiychuk, Vasyl; Juarez, Peter; Timucin, Dogan; Schuet, Stefan; Hafiychuk, Halyna

    2016-01-01

    Ultrasonic wave phenomena constitute the leading physical mechanism for nondestructive evaluation (NDE) and structural health monitoring (SHM) of solid composite materials such as carbon-fiber-reinforced polymer (CFRP) laminates. Computational models of ultrasonic guided-wave excitation, propagation, scattering, and detection in quasi-isotropic laminates can be extremely valuable in designing practically realizable NDE and SHM hardware and software with desired accuracy, reliability, efficiency, and coverage. This paper presents comparisons of guided-wave simulations for CFRP composites implemented using three different simulation codes: two commercial finite-element analysis packages, COMSOL and ABAQUS, and a custom code implementing the Elastodynamic Finite Integration Technique (EFIT). Comparisons are also made to experimental laser Doppler vibrometry data and theoretical dispersion curves.

  6. An embedded stress sensor for concrete SHM based on amorphous ferromagnetic microwires.

    PubMed

    Olivera, Jesús; González, Margarita; Fuente, José Vicente; Varga, Rastislav; Zhukov, Arkady; Anaya, José Javier

    2014-10-24

    A new smart concrete aggregate design as a candidate for applications in structural health monitoring (SHM) of critical elements in civil infrastructure is proposed. The cement-based stress/strain sensor was developed by utilizing the stress/strain sensing properties of a magnetic microwire embedded in cement-based composite (MMCC). This is a contact-less type sensor that measures variations of magnetic properties resulting from stress variations. Sensors made of these materials can be designed to satisfy the specific demand for an economic way to monitor concrete infrastructure health. For this purpose, we embedded a thin magnetic microwire in the core of a cement-based cylinder, which was inserted into the concrete specimen under study as an extra aggregate. The experimental results show that the embedded MMCC sensor is capable of measuring internal compressive stress around the range of 1-30 MPa. Two stress sensing properties of the embedded sensor under uniaxial compression were studied: the peak amplitude and peak position of magnetic switching field. The sensitivity values for the amplitude and position within the measured range were 5 mV/MPa and 2.5 µs/MPa, respectively.

  7. NDE and SHM Simulation for CFRP Composites

    NASA Technical Reports Server (NTRS)

    Leckey, Cara A. C.; Parker, F. Raymond

    2014-01-01

    Ultrasound-based nondestructive evaluation (NDE) is a common technique for damage detection in composite materials. There is a need for advanced NDE that goes beyond damage detection to damage quantification and characterization in order to enable data driven prognostics. The damage types that exist in carbon fiber-reinforced polymer (CFRP) composites include microcracking and delaminations, and can be initiated and grown via impact forces (due to ground vehicles, tool drops, bird strikes, etc), fatigue, and extreme environmental changes. X-ray microfocus computed tomography data, among other methods, have shown that these damage types often result in voids/discontinuities of a complex volumetric shape. The specific damage geometry and location within ply layers affect damage growth. Realistic threedimensional NDE and structural health monitoring (SHM) simulations can aid in the development and optimization of damage quantification and characterization techniques. This paper is an overview of ongoing work towards realistic NDE and SHM simulation tools for composites, and also discusses NASA's need for such simulation tools in aeronautics and spaceflight. The paper describes the development and implementation of a custom ultrasound simulation tool that is used to model ultrasonic wave interaction with realistic 3-dimensional damage in CFRP composites. The custom code uses elastodynamic finite integration technique and is parallelized to run efficiently on computing cluster or multicore machines.

  8. Probabilistic Assessment of High-Throughput Wireless Sensor Networks

    PubMed Central

    Kim, Robin E.; Mechitov, Kirill; Sim, Sung-Han; Spencer, Billie F.; Song, Junho

    2016-01-01

    Structural health monitoring (SHM) using wireless smart sensors (WSS) has the potential to provide rich information on the state of a structure. However, because of their distributed nature, maintaining highly robust and reliable networks can be challenging. Assessing WSS network communication quality before and after finalizing a deployment is critical to achieve a successful WSS network for SHM purposes. Early studies on WSS network reliability mostly used temporal signal indicators, composed of a smaller number of packets, to assess the network reliability. However, because the WSS networks for SHM purpose often require high data throughput, i.e., a larger number of packets are delivered within the communication, such an approach is not sufficient. Instead, in this study, a model that can assess, probabilistically, the long-term performance of the network is proposed. The proposed model is based on readily-available measured data sets that represent communication quality during high-throughput data transfer. Then, an empirical limit-state function is determined, which is further used to estimate the probability of network communication failure. Monte Carlo simulation is adopted in this paper and applied to a small and a full-bridge wireless networks. By performing the proposed analysis in complex sensor networks, an optimized sensor topology can be achieved. PMID:27258270

  9. Implementation of a pilot continuous monitoring system : Iowa Falls Arch Bridge.

    DOT National Transportation Integrated Search

    2015-06-01

    The goal of this work was to move structural health monitoring (SHM) one step closer to being ready for mainstream use by : the Iowa Department of Transportation (DOT) Office of Bridges and Structures. To meet this goal, the objective of this project...

  10. Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies.

    PubMed

    Davenport, Thaddeus M; Gorman, Jason; Joyce, M Gordon; Zhou, Tongqing; Soto, Cinque; Guttman, Miklos; Moquin, Stephanie; Yang, Yongping; Zhang, Baoshan; Doria-Rose, Nicole A; Hu, Shiu-Lok; Mascola, John R; Kwong, Peter D; Lee, Kelly K

    2016-08-02

    Antibody somatic hypermutation (SHM) and affinity maturation enhance antigen recognition by modifying antibody paratope structure to improve its complementarity with the target epitope. SHM-induced changes in paratope dynamics may also contribute to antibody maturation, but direct evidence of this is limited. Here, we examine two classes of HIV-1 broadly neutralizing antibodies (bNAbs) for SHM-induced changes in structure and dynamics, and delineate the effects of these changes on interactions with the HIV-1 envelope glycoprotein (Env). In combination with new and existing structures of unmutated and affinity matured antibody Fab fragments, we used hydrogen/deuterium exchange with mass spectrometry to directly measure Fab structural dynamics. Changes in antibody structure and dynamics were positioned to improve complementarity with Env, with changes in dynamics primarily observed at the paratope peripheries. We conclude that SHM optimizes paratope complementarity to conserved HIV-1 epitopes and restricts the mobility of paratope-peripheral residues to minimize clashes with variable features on HIV-1 Env. Copyright © 2016 Elsevier Ltd. All rights reserved.

  11. First principles molecular dynamics of molten NaI: Structure, self-diffusion, polarization effects, and charge transfer

    NASA Astrophysics Data System (ADS)

    Galamba, N.; Costa Cabral, B. J.

    2007-09-01

    The structure and self-diffusion of NaI and NaCl at temperatures close to their melting points are studied by first principles Hellmann-Feynman molecular dynamics (HFMD). The results are compared with classical MD using rigid-ion (RI) and shell-model (ShM) interionic potentials. HFMD for NaCl was reported before at a higher temperature [N. Galamba and B. J. Costa Cabral, J. Chem. Phys. 126, 124502 (2007)]. The main differences between the structures predicted by HFMD and RI MD for NaI concern the cation-cation and the anion-cation pair correlation functions. A ShM which allows only for the polarization of I- reproduces the main features of the HFMD structure of NaI. The inclusion of polarization effects for both ionic species leads to a more structured ionic liquid, although a good agreement with HFMD is also observed. HFMD Green-Kubo self-diffusion coefficients are larger than those obtained from RI and ShM simulations. A qualitative study of charge transfer in molten NaI and NaCl was also carried out with the Hirshfeld charge partitioning method. Charge transfer in molten NaI is comparable to that in NaCl, and results for NaCl at two temperatures support the view that the magnitude of charge transfer is weakly state dependent for ionic systems. Finally, Hirshfeld charge distributions indicate that differences between RI and HFMD results are mainly related to polarization effects, while the influence of charge transfer fluctuations is minimal for these systems.

  12. Development of high temperature acoustic emission sensing system using fiber Bragg grating

    NASA Astrophysics Data System (ADS)

    Pang, Dandan; Sui, Qingmei; Wang, Ming; Guo, Dongmei; Sai, Yaozhang

    2018-03-01

    In some applications in structural health monitoring (SHM), the acoustic emission (AE) detection technology is used in the high temperature environment. In this paper, a high-temperature-resistant AE sensing system is developed based on the fiber Bragg grating (FBG) sensor. A novel high temperature FBG AE sensor is designed with a high signal-to-noise ratio (SNR) compared with the traditional FBG AE sensor. The output responses of the designed sensors with different sensing fiber lengths also are investigated both theoretically and experimentally. Excellent AE detection results are obtained using the proposed FBG AE sensing system over a temperature range from 25 ° to 200 °. The experimental results indicate that this FBG AE sensing system can well meet the application requirement in AE detecting areas at high temperature.

  13. Advanced instrumentation for acousto-ultrasonic based structural health monitoring

    NASA Astrophysics Data System (ADS)

    Smithard, Joel; Galea, Steve; van der Velden, Stephen; Powlesland, Ian; Jung, George; Rajic, Nik

    2016-04-01

    Structural health monitoring (SHM) systems using structurally-integrated sensors potentially allow the ability to inspect for damage in aircraft structures on-demand and could provide a basis for the development of condition-based maintenance approaches for airframes. These systems potentially offer both substantial cost savings and performance improvements over conventional nondestructive inspection (NDI). Acousto-ultrasonics (AU), using structurallyintegrated piezoelectric transducers, offers a promising basis for broad-field damage detection in aircraft structures. For these systems to be successfully applied in the field the hardware for AU excitation and interrogation needs to be easy to use, compact, portable, light and, electrically and mechanically robust. Highly flexible and inexpensive instrumentation for basic background laboratory investigations is also required to allow researchers to tackle the numerous scientific and engineering issues associated with AU based SHM. The Australian Defence Science and Technology Group (DST Group) has developed the Acousto Ultrasonic Structural health monitoring Array Module (AUSAM+), a compact device for AU excitation and interrogation. The module, which has the footprint of a typical current generation smart phone, provides autonomous control of four send and receive piezoelectric elements, which can operate in pitch-catch or pulse-echo modes and can undertake electro-mechanical impedance measurements for transducer and structural diagnostics. Modules are designed to operate synchronously with other units, via an optical link, to accommodate larger transducer arrays. The module also caters for fibre optic sensing of acoustic waves with four intensity-based optical inputs. Temperature and electrical resistance strain gauge inputs as well as external triggering functionality are also provided. The development of a Matlab hardware object allows users to easily access the full hardware functionality of the device and provides enormous flexibility for the creation of custom interfaces. This paper discusses the impetus for the concept, and outlines key aspects of the hardware design and the module capabilities. The efficacy of the system is demonstrated through the results of first-of-class testing, as well as laboratory AU studies on a flat plate using an array of piezoelectric elements.

  14. Ultra-low power wireless sensing for long-term structural health monitoring

    NASA Astrophysics Data System (ADS)

    Bilbao, Argenis; Hoover, Davis; Rice, Jennifer; Chapman, Jamie

    2011-04-01

    Researchers have made significant progress in recent years towards realizing long-term structural health monitoring (SHM) utilizing wireless smart sensor networks (WSSNs). These efforts have focused on improving the performance and robustness of such networks to achieve high quality data acquisition and in-network processing. One of the primary challenges still facing the use of smart sensors for long-term monitoring deployments is their limited power resources. Periodically accessing the sensor nodes to change batteries is not feasible or economical in many deployment cases. While energy harvesting techniques show promise for prolonging unattended network life, low-power design and operation are still critically important. This research presents a new, fully integrated ultra-low power wireless smart sensor node and a flexible base station, both designed for long-term SHM applications. The power consumption of the sensor nodes and base station has been minimized through careful hardware selection and the implementation of power-aware network software, without sacrificing flexibility and functionality.

  15. Structural Health Monitoring of Nuclear Spent Fuel Storage Facilities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yu, Lingyu

    Interim storage of spent nuclear fuel from reactor sites has gained additional importance and urgency for resolving waste-management-related technical issues. To ensure that nuclear power remains clean energy, monitoring has been identified by DOE as a high priority cross-cutting need, necessary to determine and predict the degradation state of the systems, structures, and components (SSCs) important to safety (ITS). Therefore, nondestructive structural condition monitoring becomes a need to be installed on existing or to be integrated into future storage system to quantify the state of health or to guarantee the safe operation of nuclear power plants (NPPs) during their extendedmore » life span. In this project, the lead university and the collaborating national laboratory teamed to develop a nuclear structural health monitoring (n-SHM) system based on in-situ piezoelectric sensing technologies that can monitor structural degradation and aging for nuclear spent fuel DCSS and similar structures. We also aimed to identify and quantify possible influences of nuclear spent fuel environment (temperature and radiation) to the piezoelectric sensor system and come up with adequate solutions and guidelines therefore. We have therefore developed analytical model for piezoelectric based n-SHM methods, with considerations of temperature and irradiation influence on the model of sensing and algorithms in acoustic emission (AE), guided ultrasonic waves (GUW), and electromechanical impedance spectroscopy (EMIS). On the other side, experimentally the temperature and irradiation influence on the piezoelectric sensors and sensing capabilities were investigated. Both short-term and long-term irradiation investigation with our collaborating national laboratory were performed. Moreover, we developed multi-modal sensing, validated in laboratory setup, and conducted the testing on the We performed multi-modal sensing development, verification and validation tests on very complex structures including a medium-scale vacuum drying chamber and a small-scale mockup canister available for the desired testing. Our work developed the potential candidate for long term structural health monitoring of spent fuel canister through piezoelectric wafer sensors and provided the sensing methodologies based on AE and GUW methodologies. It overall provides an innovative system and methodology for enhancing the safe operation of nuclear power plant. All major accomplishments planned in the original proposal were successfully achieved.« less

  16. 2011 John M. Eisenberg Patient Safety and Quality Awards. Mentored implementation: building leaders and achieving results through a collaborative improvement model. Innovation in patient safety and quality at the national level.

    PubMed

    Maynard, Gregory A; Budnitz, Tina L; Nickel, Wendy K; Greenwald, Jeffrey L; Kerr, Kathleen M; Miller, Joseph A; Resnic, JoAnne N; Rogers, Kendall M; Schnipper, Jeffrey L; Stein, Jason M; Whitcomb, Winthrop F; Williams, Mark V

    2012-07-01

    The Society of Hospital Medicine (SHM) created "Mentored Implementation" (MI) programs with the dual aims of educating and mentoring hospitalists and their quality improvement (QI) teams and accelerating improvement in the inpatient setting in three signature programs: Venous Thromboembolism (VTE) Prevention, Glycemic Control, and Project BOOST (Better Outcomes for Older adults through Safe Transitions). More than 300 hospital improvement teams were enrolled in SHM MI programs in a series of cohorts. Hospitalist mentors worked with individual hospitals/health systems to guide local teams through the life cycle of a QI project. Implementation Guides and comprehensive Web-based "Resource Rooms," as well as the mentor's own experience, provided best-practice definitions, practical implementation tips, measurement strategies, and other tools. E-mail interactions and mentoring were augmented by regularly scheduled teleconferences; group webinars; and, in some instances, a site visit. Performance was tracked in a centralized data tracking center. Preliminary data on all three MI programs show significant improvement in patient outcomes, as well as enhancements of communication and leadership skills of the hospitalists and their QI teams. Although objective data on outcomes and process measures for the MI program's efficacy remain preliminary at this time, the maturing data tracking system, multiple awards, and early results indicate that the MI programs are successful in providing QI training and accelerating improvement efforts.

  17. Photoactive and self-sensing P3HT-based thin films for strain and corrosion monitoring

    NASA Astrophysics Data System (ADS)

    Ryu, Donghyeon; Loh, Kenneth J.

    2014-03-01

    Structural systems deteriorate due to excessive deformation and corrosive environments. If damage is left undetected, they can propagate to cause sudden collapse. However, one of the main difficulties of monitoring damage progression is that, for example, excessive/plastic deformation and corrosion are drastically different physical processes. Strain is a mechanical phenomenon, whereas corrosion is a complex electrochemical process. The current strategy for structural health monitoring (SHM) is to use either different types of sensors or to employ system identification for quantifying overall changes to the structure. In this study, an alternative SHM paradigm is proposed in that a single, multifunctional material would be able to selectively sense different but simultaneously occurring structural damage. In particular, a photoactive and self-sensing thin film was developed for monitoring strain and corrosion. Another unique aspect was that the films were self-sensing and did not depend on external electrical energy for operations. First, the thin films were fabricated using photoactive poly(3-hexylthiophene) (P3HT) and other functional polymers using spin-coating and layerby- layer assembly. Second, the fabricated thin films were interrogated using an ultraviolet-visible (UV-Vis) spectrophotometer for quantifying their optical response to applied external stimuli, such as strain and exposure to pH buffer solutions. Lastly, the multifunctional thin films were tested and validated for strain and pH sensing. Interrogation of these separate responses was achieved by illuminating the thin films different wavelengths of light and then measuring the corresponding electrical current generated.

  18. Induction of interferon lambda in influenza a virus infected cells treated with shRNAs against M1 transcript.

    PubMed

    Švančarová, P; Svetlíková, D; Betáková, T

    2015-06-01

    RNA interference (RNAi) represents a form of post-transcriptional gene silencing mediated by small interfering RNAs (siRNA) and provides a powerful tool to specifically inhibit viral infection. To investigate therapeutic capacity of siRNAs targeting M gene, six vectors with U1-short hairpin RNA (shRNA) expression system were prepared and tested in infected cells and animals. In infected cells, three of six shRNAs targeting M1 gene significantly (P <0,01) reduced the virus titer to 66%, 45% or 21%, respectively. Replication of IAV and levels of M1 RNAs were significantly reduced in the cells transfected with shRNAs, which decreased the virus titer. IFN-α/β altered in shRNAs-treated cells. The level of IFN-λ (type III interferon) mRNA was significantly increased in the infected cells treated with shM22, shM349, shM522, and (type I interferon) as well as IP-10 (type II interferon) mRNAs were not significantly their mixtures. The increased level of IFN-λ mRNA corresponded to significantly increased level of RIG-1 mRNA. shRNAs inhibited influenza virus infection in a gene-specific manner in co-operation with IFN-λ. Some constructs targeting the M1 transcript prolonged the survival of infected mice.

  19. Design of piezoelectric transducer layer with electromagnetic shielding and high connection reliability

    NASA Astrophysics Data System (ADS)

    Qiu, Lei; Yuan, Shenfang; Shi, Xiaoling; Huang, Tianxiang

    2012-07-01

    Piezoelectric transducer (PZT) and Lamb wave based structural health monitoring (SHM) method have been widely studied for on-line SHM of high-performance structures. To monitor large-scale structures, a dense PZTs array is required. In order to improve the placement efficiency and reduce the wire burden of the PZTs array, the concept of the piezoelectric transducers layer (PSL) was proposed. The PSL consists of PZTs, a flexible interlayer with printed wires and signal input/output interface. For on-line SHM on real aircraft structures, there are two main issues on electromagnetic interference and connection reliability of the PSL. To address the issues, an electromagnetic shielding design method of the PSL to reduce spatial electromagnetic noise and crosstalk is proposed and a combined welding-cementation process based connection reliability design method is proposed to enhance the connection reliability between the PZTs and the flexible interlayer. Two experiments on electromagnetic interference suppression are performed to validate the shielding design of the PSL. The experimental results show that the amplitudes of the spatial electromagnetic noise and crosstalk output from the shielded PSL developed by this paper are - 15 dB and - 25 dB lower than those of the ordinary PSL, respectively. Other two experiments on temperature durability ( - 55 °C-80 °C ) and strength durability (160-1600μɛ, one million load cycles) are applied to the PSL to validate the connection reliability. The low repeatability errors (less than 3% and less than 5%, respectively) indicate that the developed PSL is of high connection reliability and long fatigue life.

  20. Neuro-fuzzy computing for vibration-based damage localization and severity estimation in an experimental wind turbine blade with superimposed operational effects

    NASA Astrophysics Data System (ADS)

    Hoell, Simon; Omenzetter, Piotr

    2016-04-01

    Fueled by increasing demand for carbon neutral energy, erections of ever larger wind turbines (WTs), with WT blades (WTBs) with higher flexibilities and lower buckling capacities lead to increasing operation and maintenance costs. This can be counteracted with efficient structural health monitoring (SHM), which allows scheduling maintenance actions according to the structural state and preventing dramatic failures. The present study proposes a novel multi-step approach for vibration-based structural damage localization and severity estimation for application in operating WTs. First, partial autocorrelation coefficients (PACCs) are estimated from vibrational responses. Second, principal component analysis is applied to PACCs from the healthy structure in order to calculate scores. Then, the scores are ranked with respect to their ability to differentiate different damage scenarios. This ranking information is used for constructing hierarchical adaptive neuro-fuzzy inference systems (HANFISs), where cross-validation is used to identify optimal numbers of hierarchy levels. Different HANFISs are created for the purposes of structural damage localization and severity estimation. For demonstrating the applicability of the approach, experimental data are superimposed with signals from numerical simulations to account for characteristics of operational noise. For the physical experiments, a small scale WTB is excited with a domestic fan and damage scenarios are introduced non-destructively by attaching small masses. Numerical simulations are also performed for a representative fully functional small WT operating in turbulent wind. The obtained results are promising for future applications of vibration-based SHM to facilitate improved safety and reliability of WTs at lower costs.

  1. Crack Propagation Analysis Using Acoustic Emission Sensors for Structural Health Monitoring Systems

    DOE PAGES

    Kral, Zachary; Horn, Walter; Steck, James

    2013-01-01

    Aerospace systems are expected to remain in service well beyond their designed life. Consequently, maintenance is an important issue. A novel method of implementing artificial neural networks and acoustic emission sensors to form a structural health monitoring (SHM) system for aerospace inspection routines was the focus of this research. Simple structural elements, consisting of flat aluminum plates of AL 2024-T3, were subjected to increasing static tensile loading. As the loading increased, designed cracks extended in length, releasing strain waves in the process. Strain wave signals, measured by acoustic emission sensors, were further analyzed in post-processing by artificial neural networks (ANN).more » Several experiments were performed to determine the severity and location of the crack extensions in the structure. ANNs were trained on a portion of the data acquired by the sensors and the ANNs were then validated with the remaining data. The combination of a system of acoustic emission sensors, and an ANN could determine crack extension accurately. The difference between predicted and actual crack extensions was determined to be between 0.004 in. and 0.015 in. with 95% confidence. These ANNs, coupled with acoustic emission sensors, showed promise for the creation of an SHM system for aerospace systems.« less

  2. Crack Propagation Analysis Using Acoustic Emission Sensors for Structural Health Monitoring Systems

    PubMed Central

    Horn, Walter; Steck, James

    2013-01-01

    Aerospace systems are expected to remain in service well beyond their designed life. Consequently, maintenance is an important issue. A novel method of implementing artificial neural networks and acoustic emission sensors to form a structural health monitoring (SHM) system for aerospace inspection routines was the focus of this research. Simple structural elements, consisting of flat aluminum plates of AL 2024-T3, were subjected to increasing static tensile loading. As the loading increased, designed cracks extended in length, releasing strain waves in the process. Strain wave signals, measured by acoustic emission sensors, were further analyzed in post-processing by artificial neural networks (ANN). Several experiments were performed to determine the severity and location of the crack extensions in the structure. ANNs were trained on a portion of the data acquired by the sensors and the ANNs were then validated with the remaining data. The combination of a system of acoustic emission sensors, and an ANN could determine crack extension accurately. The difference between predicted and actual crack extensions was determined to be between 0.004 in. and 0.015 in. with 95% confidence. These ANNs, coupled with acoustic emission sensors, showed promise for the creation of an SHM system for aerospace systems. PMID:24023536

  3. Structural Health Monitoring of a Composite Panel Based on PZT Sensors and a Transfer Impedance Framework

    PubMed Central

    Dziendzikowski, Michal; Niedbala, Patryk; Kurnyta, Artur; Kowalczyk, Kamil; Dragan, Krzysztof

    2018-01-01

    One of the ideas for development of Structural Health Monitoring (SHM) systems is based on excitation of elastic waves by a network of PZT piezoelectric transducers integrated with the structure. In the paper, a variant of the so-called Transfer Impedance (TI) approach to SHM is followed. Signal characteristics, called the Damage Indices (DIs), were proposed for data presentation and analysis. The idea underlying the definition of DIs was to maintain most of the information carried by the voltage induced on PZT sensors by elastic waves. In particular, the DIs proposed in the paper should be sensitive to all types of damage which can influence the amplitude or the phase of the voltage induced on the sensor. Properties of the proposed DIs were investigated experimentally using a GFRP composite panel equipped with PZT networks attached to its surface and embedded into its internal structure. Repeatability and stability of DI indications under controlled conditions were verified in tests. Also, some performance indicators for surface-attached and structure-embedded sensors were obtained. The DIs’ behavior was dependent mostly on the presence of a simulated damage in the structure. Anisotropy of mechanical properties of the specimen, geometrical properties of PZT network as well as, to some extent, the technology of sensor integration with the structure were irrelevant for damage indication. This property enables the method to be used for damage detection and classification. PMID:29751664

  4. The Supporting Healthy Marriage Evaluation: Early Lessons from the Implementation of a Relationship and Marriage Skills Program for Low-Income Married Couples

    ERIC Educational Resources Information Center

    Gaubert, Jennifer Miller; Knox, Virginia; Alderson, Desiree Principe; Dalton, Christopher; Fletcher, Kate; McCormick, Meghan

    2010-01-01

    This report presents early implementation and operational lessons from the Supporting Healthy Marriage (SHM) evaluation. Funded by the Administration for Children and Families, SHM uses a rigorous research design to test the effectiveness of a new approach to improving outcomes for low-income children: strengthening the marriages and relationships…

  5. Efficient Airframe Management Using In-Situ Structural Health Monitoring

    DTIC Science & Technology

    2012-07-01

    As a result, the Air Force intends to transition to a process that services aircraft based on their actual condition instead of the presumptive...at predetermined times regardless of their actual conditions . This _____________ Mark M. Derriso and Matthew S. Leonard, Air Force Research...services aircraft based on their actual condition instead of the presumptive schedule-based approach. Structural health monitoring (SHM) technologies are

  6. Structural Health Monitoring of Civil Infrastructure Using Optical Fiber Sensing Technology: A Comprehensive Review

    PubMed Central

    Ye, X. W.; Su, Y. H.; Han, J. P.

    2014-01-01

    In the last two decades, a significant number of innovative sensing systems based on optical fiber sensors have been exploited in the engineering community due to their inherent distinctive advantages such as small size, light weight, immunity to electromagnetic interference (EMI) and corrosion, and embedding capability. A lot of optical fiber sensor-based monitoring systems have been developed for continuous measurement and real-time assessment of diversified engineering structures such as bridges, buildings, tunnels, pipelines, wind turbines, railway infrastructure, and geotechnical structures. The purpose of this review article is devoted to presenting a summary of the basic principles of various optical fiber sensors, innovation in sensing and computational methodologies, development of novel optical fiber sensors, and the practical application status of the optical fiber sensing technology in structural health monitoring (SHM) of civil infrastructure. PMID:25133250

  7. Structural health monitoring of civil infrastructure using optical fiber sensing technology: a comprehensive review.

    PubMed

    Ye, X W; Su, Y H; Han, J P

    2014-01-01

    In the last two decades, a significant number of innovative sensing systems based on optical fiber sensors have been exploited in the engineering community due to their inherent distinctive advantages such as small size, light weight, immunity to electromagnetic interference (EMI) and corrosion, and embedding capability. A lot of optical fiber sensor-based monitoring systems have been developed for continuous measurement and real-time assessment of diversified engineering structures such as bridges, buildings, tunnels, pipelines, wind turbines, railway infrastructure, and geotechnical structures. The purpose of this review article is devoted to presenting a summary of the basic principles of various optical fiber sensors, innovation in sensing and computational methodologies, development of novel optical fiber sensors, and the practical application status of the optical fiber sensing technology in structural health monitoring (SHM) of civil infrastructure.

  8. Generation and Repair of AID-initiated DNA Lesions in B Lymphocytes

    PubMed Central

    Chen, Zhangguo; Wang, Jing H.

    2014-01-01

    Activation-induced deaminase (AID) initiates the secondary antibody diversification process in B lymphocytes. In mammalian B cells, this process includes somatic hypermutation (SHM) and class switch recombination (CSR), both of which require AID. AID induces U:G mismatch lesions in DNA that are subsequently converted into point mutations or DNA double stranded breaks during SHM/CSR. In a physiological context, AID targets immunoglobulin (Ig) loci to mediate SHM/CSR. However, recent studies reveal genome-wide access of AID to numerous non-Ig loci. Thus, AID poses a threat to the genome of B cells if AID-initiated DNA lesions cannot be properly repaired. In this review, we focus on the molecular mechanisms that regulate the specificity of AID targeting and the repair pathways responsible for processing AID-initiated DNA lesions. PMID:24748462

  9. Identifying Time Periods of Minimal Thermal Gradient for Temperature-Driven Structural Health Monitoring

    PubMed Central

    Reilly, John; Glisic, Branko

    2018-01-01

    Temperature changes play a large role in the day to day structural behavior of structures, but a smaller direct role in most contemporary Structural Health Monitoring (SHM) analyses. Temperature-Driven SHM will consider temperature as the principal driving force in SHM, relating a measurable input temperature to measurable output generalized strain (strain, curvature, etc.) and generalized displacement (deflection, rotation, etc.) to create three-dimensional signatures descriptive of the structural behavior. Identifying time periods of minimal thermal gradient provides the foundation for the formulation of the temperature–deformation–displacement model. Thermal gradients in a structure can cause curvature in multiple directions, as well as non-linear strain and stress distributions within the cross-sections, which significantly complicates data analysis and interpretation, distorts the signatures, and may lead to unreliable conclusions regarding structural behavior and condition. These adverse effects can be minimized if the signatures are evaluated at times when thermal gradients in the structure are minimal. This paper proposes two classes of methods based on the following two metrics: (i) the range of raw temperatures on the structure, and (ii) the distribution of the local thermal gradients, for identifying time periods of minimal thermal gradient on a structure with the ability to vary the tolerance of acceptable thermal gradients. The methods are tested and validated with data collected from the Streicker Bridge on campus at Princeton University. PMID:29494496

  10. Identifying Time Periods of Minimal Thermal Gradient for Temperature-Driven Structural Health Monitoring.

    PubMed

    Reilly, John; Glisic, Branko

    2018-03-01

    Temperature changes play a large role in the day to day structural behavior of structures, but a smaller direct role in most contemporary Structural Health Monitoring (SHM) analyses. Temperature-Driven SHM will consider temperature as the principal driving force in SHM, relating a measurable input temperature to measurable output generalized strain (strain, curvature, etc.) and generalized displacement (deflection, rotation, etc.) to create three-dimensional signatures descriptive of the structural behavior. Identifying time periods of minimal thermal gradient provides the foundation for the formulation of the temperature-deformation-displacement model. Thermal gradients in a structure can cause curvature in multiple directions, as well as non-linear strain and stress distributions within the cross-sections, which significantly complicates data analysis and interpretation, distorts the signatures, and may lead to unreliable conclusions regarding structural behavior and condition. These adverse effects can be minimized if the signatures are evaluated at times when thermal gradients in the structure are minimal. This paper proposes two classes of methods based on the following two metrics: (i) the range of raw temperatures on the structure, and (ii) the distribution of the local thermal gradients, for identifying time periods of minimal thermal gradient on a structure with the ability to vary the tolerance of acceptable thermal gradients. The methods are tested and validated with data collected from the Streicker Bridge on campus at Princeton University.

  11. Probabilistic seismic history matching using binary images

    NASA Astrophysics Data System (ADS)

    Davolio, Alessandra; Schiozer, Denis Jose

    2018-02-01

    Currently, the goal of history-matching procedures is not only to provide a model matching any observed data but also to generate multiple matched models to properly handle uncertainties. One such approach is a probabilistic history-matching methodology based on the discrete Latin Hypercube sampling algorithm, proposed in previous works, which was particularly efficient for matching well data (production rates and pressure). 4D seismic (4DS) data have been increasingly included into history-matching procedures. A key issue in seismic history matching (SHM) is to transfer data into a common domain: impedance, amplitude or pressure, and saturation. In any case, seismic inversions and/or modeling are required, which can be time consuming. An alternative to avoid these procedures is using binary images in SHM as they allow the shape, rather than the physical values, of observed anomalies to be matched. This work presents the incorporation of binary images in SHM within the aforementioned probabilistic history matching. The application was performed with real data from a segment of the Norne benchmark case that presents strong 4D anomalies, including softening signals due to pressure build up. The binary images are used to match the pressurized zones observed in time-lapse data. Three history matchings were conducted using: only well data, well and 4DS data, and only 4DS. The methodology is very flexible and successfully utilized the addition of binary images for seismic objective functions. Results proved the good convergence of the method in few iterations for all three cases. The matched models of the first two cases provided the best results, with similar well matching quality. The second case provided models presenting pore pressure changes according to the expected dynamic behavior (pressurized zones) observed on 4DS data. The use of binary images in SHM is relatively new with few examples in the literature. This work enriches this discussion by presenting a new application to match pressure in a reservoir segment with complex pressure behavior.

  12. An Embedded Stress Sensor for Concrete SHM Based on Amorphous Ferromagnetic Microwires

    PubMed Central

    Olivera, Jesús; González, Margarita; Fuente, José Vicente; Varga, Rastislav; Zhukov, Arkady; Anaya, José Javier

    2014-01-01

    A new smart concrete aggregate design as a candidate for applications in structural health monitoring (SHM) of critical elements in civil infrastructure is proposed. The cement-based stress/strain sensor was developed by utilizing the stress/strain sensing properties of a magnetic microwire embedded in cement-based composite (MMCC). This is a contact-less type sensor that measures variations of magnetic properties resulting from stress variations. Sensors made of these materials can be designed to satisfy the specific demand for an economic way to monitor concrete infrastructure health. For this purpose, we embedded a thin magnetic microwire in the core of a cement-based cylinder, which was inserted into the concrete specimen under study as an extra aggregate. The experimental results show that the embedded MMCC sensor is capable of measuring internal compressive stress around the range of 1–30 MPa. Two stress sensing properties of the embedded sensor under uniaxial compression were studied: the peak amplitude and peak position of magnetic switching field. The sensitivity values for the amplitude and position within the measured range were 5 mV/MPa and 2.5 μs/MPa, respectively. PMID:25347582

  13. Phase II : correlation between experimental and finite element analysis : Alaska bridge 255-Chulitna River bridge.

    DOT National Transportation Integrated Search

    2014-09-01

    In this study, we will monitor the behavior of the Alaska Chulitna Bridge for the specific purpose of assisting the DOT in performing an accurate : condition assessment of this bridge. : Based on the state-of-the-art SHM knowledge and technologies wi...

  14. Monitoring of Engineering Buildings Behaviour Within the Disaster Management System

    NASA Astrophysics Data System (ADS)

    Oku Topal, G.; Gülal, E.

    2017-11-01

    The Disaster management aims to prevent events that result in disaster or to reduce their losses. Monitoring of engineering buildings, identification of unusual movements and taking the necessary precautions are very crucial for determination of the disaster risk so possible prevention could be taken to reduce big loss. Improving technology, increasing population due to increased construction and these areas largest economy lead to offer damage detection strategies. Structural Health Monitoring (SHM) is the most effective of these strategies. SHM research is very important to maintain all this structuring safely. The purpose of structural monitoring is determining in advance of possible accidents and taking necessary precaution. In this paper, determining the behaviour of construction using Global Positioning System (GPS) is investigated. For this purpose shaking table tests were performed. Shaking table was moved at different amplitude and frequency aiming to determine these movement with a GPS measuring system. The obtained data were evaluated by analysis of time series and Fast Fourier Transformation techniques and the frequency and amplitude values are calculated. By examining the results of the tests made, it will be determined whether the GPS measurement method can accurately detect the movements of the engineering structures.

  15. A Review of Distributed Optical Fiber Sensors for Civil Engineering Applications

    PubMed Central

    Barrias, António; Casas, Joan R.; Villalba, Sergi

    2016-01-01

    The application of structural health monitoring (SHM) systems to civil engineering structures has been a developing studied and practiced topic, that has allowed for a better understanding of structures’ conditions and increasingly lead to a more cost-effective management of those infrastructures. In this field, the use of fiber optic sensors has been studied, discussed and practiced with encouraging results. The possibility of understanding and monitor the distributed behavior of extensive stretches of critical structures it’s an enormous advantage that distributed fiber optic sensing provides to SHM systems. In the past decade, several R & D studies have been performed with the goal of improving the knowledge and developing new techniques associated with the application of distributed optical fiber sensors (DOFS) in order to widen the range of applications of these sensors and also to obtain more correct and reliable data. This paper presents, after a brief introduction to the theoretical background of DOFS, the latest developments related with the improvement of these products by presenting a wide range of laboratory experiments as well as an extended review of their diverse applications in civil engineering structures. PMID:27223289

  16. A Review of Distributed Optical Fiber Sensors for Civil Engineering Applications.

    PubMed

    Barrias, António; Casas, Joan R; Villalba, Sergi

    2016-05-23

    The application of structural health monitoring (SHM) systems to civil engineering structures has been a developing studied and practiced topic, that has allowed for a better understanding of structures' conditions and increasingly lead to a more cost-effective management of those infrastructures. In this field, the use of fiber optic sensors has been studied, discussed and practiced with encouraging results. The possibility of understanding and monitor the distributed behavior of extensive stretches of critical structures it's an enormous advantage that distributed fiber optic sensing provides to SHM systems. In the past decade, several R & D studies have been performed with the goal of improving the knowledge and developing new techniques associated with the application of distributed optical fiber sensors (DOFS) in order to widen the range of applications of these sensors and also to obtain more correct and reliable data. This paper presents, after a brief introduction to the theoretical background of DOFS, the latest developments related with the improvement of these products by presenting a wide range of laboratory experiments as well as an extended review of their diverse applications in civil engineering structures.

  17. A bio-inspired memory model for structural health monitoring

    NASA Astrophysics Data System (ADS)

    Zheng, Wei; Zhu, Yong

    2009-04-01

    Long-term structural health monitoring (SHM) systems need intelligent management of the monitoring data. By analogy with the way the human brain processes memories, we present a bio-inspired memory model (BIMM) that does not require prior knowledge of the structure parameters. The model contains three time-domain areas: a sensory memory area, a short-term memory area and a long-term memory area. First, the initial parameters of the structural state are specified to establish safety criteria. Then the large amount of monitoring data that falls within the safety limits is filtered while the data outside the safety limits are captured instantly in the sensory memory area. Second, disturbance signals are distinguished from danger signals in the short-term memory area. Finally, the stable data of the structural balance state are preserved in the long-term memory area. A strategy for priority scheduling via fuzzy c-means for the proposed model is then introduced. An experiment on bridge tower deformation demonstrates that the proposed model can be applied for real-time acquisition, limited-space storage and intelligent mining of the monitoring data in a long-term SHM system.

  18. The impact of baryons on the direct detection of dark matter

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kelso, Chris; Savage, Christopher; Freese, Katherine

    2016-08-01

    The spatial and velocity distributions of dark matter particles in the Milky Way Halo affect the signals expected to be observed in searches for dark matter. Results from direct detection experiments are often analyzed assuming a simple isothermal distribution of dark matter, the Standard Halo Model (SHM). Yet there has been skepticism regarding the validity of this simple model due to the complicated gravitational collapse and merger history of actual galaxies. In this paper we compare the SHM to the results of cosmological hydrodynamical simulations of galaxy formation to investigate whether or not the SHM is a good representation ofmore » the true WIMP distribution in the analysis of direct detection data. We examine two Milky Way-like galaxies from the MaGICC cosmological simulations (a) with dark matter only and (b) with baryonic physics included. The inclusion of baryons drives the shape of the DM halo to become more spherical and makes the velocity distribution of dark matter particles less anisotropic especially at large heliocentric velocities, thereby making the SHM a better fit. We also note that we do not find a significant disk-like rotating dark matter component in either of the two galaxy halos with baryons that we examine, suggesting that dark disks are not a generic prediction of cosmological hydrodynamical simulations. We conclude that in the Solar neighborhood, the SHM is in fact a good approximation to the true dark matter distribution in these cosmological simulations (with baryons) which are reasonable representations of the Milky Way, and hence can also be used for the purpose of dark matter direct detection calculations.« less

  19. Fatigue disbonding analysis of wide composite panels by means of Lamb waves

    NASA Astrophysics Data System (ADS)

    Michalcová, Lenka; Rechcígel, Lukáš; Bělský, Petr; Kucharský, Pavel

    2018-03-01

    Guided wave-based monitoring of composite structures plays an important role in the area of structural health monitoring (SHM) of aerospace structures. Adhesively bonded joints have not yet fulfilled current airworthiness requirements; hence, assemblies of carbon fibre-reinforced parts still require mechanical fasteners, and a verified SHM method with reliable disbonding/delamination detection and propagation assessment is needed. This study investigated the disbonding/delamination propagation in adhesively bonded panels using Lamb waves during fatigue tests. Analyses focused on the proper frequency and mode selection, sensor placement and selection of parameter sensitive to the growth of disbonding areas. Piezoelectric transducers placed across the bonded area were used as actuators and sensors. Lamb wave propagation was investigated considering the actual shape of the crack front and the mode of the crack propagation. The actual cracked area was determined by ultrasonic A-scans. A correlation between the crack propagation rate and the A0 mode velocity was found.

  20. 3D Ultrasonic Wave Simulations for Structural Health Monitoring

    NASA Technical Reports Server (NTRS)

    Campbell, Leckey Cara A/; Miler, Corey A.; Hinders, Mark K.

    2011-01-01

    Structural health monitoring (SHM) for the detection of damage in aerospace materials is an important area of research at NASA. Ultrasonic guided Lamb waves are a promising SHM damage detection technique since the waves can propagate long distances. For complicated flaw geometries experimental signals can be difficult to interpret. High performance computing can now handle full 3-dimensional (3D) simulations of elastic wave propagation in materials. We have developed and implemented parallel 3D elastodynamic finite integration technique (3D EFIT) code to investigate ultrasound scattering from flaws in materials. EFIT results have been compared to experimental data and the simulations provide unique insight into details of the wave behavior. This type of insight is useful for developing optimized experimental SHM techniques. 3D EFIT can also be expanded to model wave propagation and scattering in anisotropic composite materials.

  1. Novelty detection applied to vibration data from a CX-100 wind turbine blade under fatigue loading

    NASA Astrophysics Data System (ADS)

    Dervilis, N.; Choi, M.; Antoniadou, I.; Farinholt, K. M.; Taylor, S. G.; Barthorpe, R. J.; Park, G.; Worden, K.; Farrar, C. R.

    2012-08-01

    The remarkable evolution of new generation wind turbines has led to a dramatic increase of wind turbine blade size. In turn, a reliable structural health monitoring (SHM) system will be a key factor for the successful implementation of such systems. Detection of damage at an early stage is a crucial issue as blade failure would be a catastrophic result for the entire wind turbine. In this study the SHM analysis will be based on experimental measurements of Frequency Response Functions (FRFs) extracted by using an input/output acquisition technique under a fatigue loading of a 9m CX-100 blade at the National Renewable Energy Laboratory (NREL) and National Wind Technology Center (NWTC) performed in the Los Alamos National Laboratory. The blade was harmonically excited at its first natural frequency using a Universal Resonant Excitation (UREX) system. For analysis, the Auto-Associative Neural Network (AANN) is a non-parametric method where a set of damage sensitive features gathered from the measured structure are used to train a network that acts as a novelty detector. This traditionally has a highly complex "bottleneck" structure with five layers in the AANN. In the current paper, a new attempt is also exploited based on an AANN with one hidden layer in order to reduce the theoretical and computational difficulties. Damage detection of composite bodies of blades is a "grand challenge" due to varying aerodynamic and gravitational loads and environmental conditions. A study of the noise tolerant capability of the AANN which is associated to its generalisation capacity is addressed. It will be shown that vibration response data combined with AANNs is a robust and powerful tool, offering novelty detection even when operational and environmental variations are present. The AANN is a method which has not yet been widely used in the structural health monitoring of composite blades.

  2. Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination

    PubMed Central

    Nicolas, Laura; Cols, Montserrat; Choi, Jee Eun; Chaudhuri, Jayanta; Vuong, Bao

    2018-01-01

    Adaptive immune responses require the generation of a diverse repertoire of immunoglobulins (Igs) that can recognize and neutralize a seemingly infinite number of antigens. V(D)J recombination creates the primary Ig repertoire, which subsequently is modified by somatic hypermutation (SHM) and class switch recombination (CSR). SHM promotes Ig affinity maturation whereas CSR alters the effector function of the Ig. Both SHM and CSR require activation-induced cytidine deaminase (AID) to produce dU:dG mismatches in the Ig locus that are transformed into untemplated mutations in variable coding segments during SHM or DNA double-strand breaks (DSBs) in switch regions during CSR. Within the Ig locus, DNA repair pathways are diverted from their canonical role in maintaining genomic integrity to permit AID-directed mutation and deletion of gene coding segments. Recently identified proteins, genes, and regulatory networks have provided new insights into the temporally and spatially coordinated molecular interactions that control the formation and repair of DSBs within the Ig locus. Unravelling the genetic program that allows B cells to selectively alter the Ig coding regions while protecting non-Ig genes from DNA damage advances our understanding of the molecular processes that maintain genomic integrity as well as humoral immunity. PMID:29744038

  3. Fatigue Analysis Before and After Shaker Exercise: Physiologic Tool for Exercise Design

    PubMed Central

    White, Kevin T.; Easterling, Caryn; Roberts, Niles; Shaker, Reza

    2016-01-01

    Recent studies suggest that the Shaker exercise induces fatigue in the upper esophageal sphincter (UES) opening muscles and sternocleidomastoid (SCM), with the SCMs fatiguing earliest. The aim of this study was to measure fatigue induced by the isometric portion of the Shaker exercise by measuring the rate of change in the median frequency (MF rate) of the power spectral density (PSD) function, which is interpreted as proportional to the rate of fatigue, from surface electromyography (EMG) of suprahyoid (SHM), infrahyoid (IHM), and SCM. EMG data compared fatigue-related changes from 20-, 40-, and 60-s isometric hold durations of the Shaker exercise. We found that fatigue-related changes were manifested during the 20-s hold. The findings confirm that the SCM fatigues initially and as fast as or faster than the SHM and IHM. In addition, upon completion of the exercise protocol, the SCM had a decreased MF rate, implying improved fatigue resistance, while the SHM and IHM showed increased MF rates, implying that these muscles increased their fatiguing effort. We conclude that the Shaker exercise initially leads to increased fatigue resistance of the SCM, after which the exercise loads the less fatigue-resistant SHM and IHM, potentiating the therapeutic effect of the Shaker exercise regimen with continued exercise performance. PMID:18369673

  4. Usefulness of a Darwinian System in a Biotechnological Application: Evolution of Optical Window Fluorescent Protein Variants under Selective Pressure

    PubMed Central

    Ng, David; Pauli, Jutta; Resch-Genger, Ute; Kühn, Enrico; Heuer, Steffen; Beisker, Wolfgang; Köster, Reinhard W.; Zitzelsberger, Horst; Caldwell, Randolph B

    2014-01-01

    With rare exceptions, natural evolution is an extremely slow process. One particularly striking exception in the case of protein evolution is in the natural production of antibodies. Developing B cells activate and diversify their immunoglobulin (Ig) genes by recombination, gene conversion (GC) and somatic hypermutation (SHM). Iterative cycles of hypermutation and selection continue until antibodies of high antigen binding specificity emerge (affinity maturation). The avian B cell line DT40, a cell line which is highly amenable to genetic manipulation and exhibits a high rate of targeted integration, utilizes both GC and SHM. Targeting the DT40's diversification machinery onto transgenes of interest inserted into the Ig loci and coupling selective pressure based on the desired outcome mimics evolution. Here we further demonstrate the usefulness of this platform technology by selectively pressuring a large shift in the spectral properties of the fluorescent protein eqFP615 into the highly stable and advanced optical imaging expediting fluorescent protein Amrose. The method is advantageous as it is time and cost effective and no prior knowledge of the outcome protein's structure is necessary. Amrose was evolved to have high excitation at 633 nm and excitation/emission into the far-red, which is optimal for whole-body and deep tissue imaging as we demonstrate in the zebrafish and mouse model. PMID:25192257

  5. Usefulness of a Darwinian system in a biotechnological application: evolution of optical window fluorescent protein variants under selective pressure.

    PubMed

    Schoetz, Ulrike; Deliolanis, Nikolaos C; Ng, David; Pauli, Jutta; Resch-Genger, Ute; Kühn, Enrico; Heuer, Steffen; Beisker, Wolfgang; Köster, Reinhard W; Zitzelsberger, Horst; Caldwell, Randolph B

    2014-01-01

    With rare exceptions, natural evolution is an extremely slow process. One particularly striking exception in the case of protein evolution is in the natural production of antibodies. Developing B cells activate and diversify their immunoglobulin (Ig) genes by recombination, gene conversion (GC) and somatic hypermutation (SHM). Iterative cycles of hypermutation and selection continue until antibodies of high antigen binding specificity emerge (affinity maturation). The avian B cell line DT40, a cell line which is highly amenable to genetic manipulation and exhibits a high rate of targeted integration, utilizes both GC and SHM. Targeting the DT40's diversification machinery onto transgenes of interest inserted into the Ig loci and coupling selective pressure based on the desired outcome mimics evolution. Here we further demonstrate the usefulness of this platform technology by selectively pressuring a large shift in the spectral properties of the fluorescent protein eqFP615 into the highly stable and advanced optical imaging expediting fluorescent protein Amrose. The method is advantageous as it is time and cost effective and no prior knowledge of the outcome protein's structure is necessary. Amrose was evolved to have high excitation at 633 nm and excitation/emission into the far-red, which is optimal for whole-body and deep tissue imaging as we demonstrate in the zebrafish and mouse model.

  6. Development of Integrated and Flexible Ultrasonic Transducers for Aerospace Applications

    NASA Astrophysics Data System (ADS)

    Wu, Kuo-Ting

    2011-12-01

    High temperature (HT) integrated (IUTs) and flexible ultrasonic transducers (FUTs) for potential aerospace applications in the area of nondestructive testing (NDT) and structural health monitoring (SHM) are developed. The main merits are that IUTs can be fabricated on-site and FUTs are feasible and attractive for on-site installation. The piezoelectric composite films of these HT ultrasonic transducers (HTUTs) are made by sol-gel spray fabrication. Lead-zirconate titanate composite (PZT-c), bismuth titanate composite (BIT-c), or lithium niobate composite (LiNbO3-c) films were coated onto metallic substrates with planar and curved surfaces and investigated as IUTs. Their maximum operating temperatures were demonstrated at up to 150°C, 400°C, and 800°C, respectively. PZT-c or BIT-c films were coated onto 75 mum or 38 mum thick metallic membranes and were investigated as FUTs. They can be bonded onto flat or curved surfaces for NDT and SHM. An FUT made of BIT-c film coated onto a stainless steel membrane glued onto a steel plate was performed at up to 300°C. Besides being coated onto metallic materials, sol-gel sprayed composite films were also coated onto graphite/epoxy (Gr/Ep) plates as IUTs and 50 mum thick polyimide films as FUTs for the thickness and delamination evaluation. Using acoustic mode conversion techniques, HTUTs for shear (S) wave, surface acoustic wave (SAW), and plate acoustic wave (PAW), have been developed. HT ultrasonic probes simultaneously producing one longitudinal (L) and two orthogonally polarized S waves were demonstrated in metallic and Plexiglas probes. The potential applications of these probes were discussed. Also applying mode conversion approaches, HT symmetrical, anti-symmetrical, and shear horizontal (SH) PAWs UTs for NDT and SHM were developed. The results showed that the SH PAWs may be the best candidate for NDT and SHM purposes for plate structures. Generation and detection of guided acoustic waves for NDT were demonstrated by using IUTs or FUTs with metallic wedges, mechanical gratings or interdigital transducers as well. The experiments with these three approaches were performed at up to 300°C. Furthermore, two non-contact ultrasonic measurement techniques by sol-gel sprayed composite films were presented in this thesis. One is using lasers to generate ultrasound and IUTs as receivers, and the other is using induction-based non-contact ultrasonic measurement technique with IUTs. NDT of bonded composite patches on aluminum plates was performed using laser generated ultrasound and IUT receivers. The induction-based ultrasonic measurement of a Gr/Ep composite plate rotated at 1000 rpm was demonstrated. The IUTs and FUTs developed in this thesis are able to provide signals with good signal-to-noise ratios at elevated temperature on structures and parts having a curved surface. They are light weight and miniature in size. They may be used for real-time, in situ, nondestructive local and global (large area) damage detection and assessment in aerospace NDT and SHM applications.

  7. Multivariate analysis for the optimization of microfluidics-assisted nanoprecipitation method intended for the loading of small hydrophilic drugs into PLGA nanoparticles.

    PubMed

    Chiesa, E; Dorati, R; Modena, T; Conti, B; Genta, I

    2018-01-30

    Design of Experiment-assisted evaluation of critical process (total flow rate, TFR, flow rate ratio, FRR) and formulation (polymer concentration and structure, drug:polymer ratio) variables in a novel microfluidics-based device, a staggered herringbone micromixer (SHM), for poly(lactic-co-glycolic acid) copolymer (PLGA) nanoparticles (NPs) manufacturing was performed in order to systematically evaluate and mathematically describe their effects on NPs sizes and drug encapsulation; a small hydrophilic moiety, N-acetylcysteine, was chosen as challenging model drug. SHM-assisted nanoprecipitation method consistently yielded NPs with tailor made sizes (in the range of 100-900 nm) and polydispersity index range from 0.061 to 0.286. Significant effects on NPs sizes were highlighted for TFR and FRR: increasing TFR (from 5 to 15 mL/min) and decreasing FRR (from 1:1 to 1:5 v/v, acetonitrile: buffer) NPs with mean diameter <200 nm were obtained. SHM technique allowed for flexible, application-specific tuning of PLGA NPs size using organic solvents with relatively low toxicity (acetone, acetonitrile), varying aqueous phase composition (Tris buffer vs PVA aqueous solution) and PLGA characteristics (Mw ranging from 25-90 kDa, capped or un-capped PLGA, different lactide:glycolide molar ratio). A very satisfactory N-Ac encapsulation efficiency (more than 67%) and a prolonged release (by 168 h) were achieved. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Automated analysis of long-term bridge behavior and health using a cyber-enabled wireless monitoring system

    NASA Astrophysics Data System (ADS)

    O'Connor, Sean M.; Zhang, Yilan; Lynch, Jerome; Ettouney, Mohammed; van der Linden, Gwen

    2014-04-01

    A worthy goal for the structural health monitoring field is the creation of a scalable monitoring system architecture that abstracts many of the system details (e.g., sensors, data) from the structure owner with the aim of providing "actionable" information that aids in their decision making process. While a broad array of sensor technologies have emerged, the ability for sensing systems to generate large amounts of data have far outpaced advances in data management and processing. To reverse this trend, this study explores the creation of a cyber-enabled wireless SHM system for highway bridges. The system is designed from the top down by considering the damage mechanisms of concern to bridge owners and then tailoring the sensing and decision support system around those concerns. The enabling element of the proposed system is a powerful data repository system termed SenStore. SenStore is designed to combine sensor data with bridge meta-data (e.g., geometric configuration, material properties, maintenance history, sensor locations, sensor types, inspection history). A wireless sensor network deployed to a bridge autonomously streams its measurement data to SenStore via a 3G cellular connection for storage. SenStore securely exposes the bridge meta- and sensor data to software clients that can process the data to extract information relevant to the decision making process of the bridge owner. To validate the proposed cyber-enable SHM system, the system is implemented on the Telegraph Road Bridge (Monroe, MI). The Telegraph Road Bridge is a traditional steel girder-concrete deck composite bridge located along a heavily travelled corridor in the Detroit metropolitan area. A permanent wireless sensor network has been installed to measure bridge accelerations, strains and temperatures. System identification and damage detection algorithms are created to automatically mine bridge response data stored in SenStore over an 18-month period. Tools like Gaussian Process (GP) regression are used to predict changes in the bridge behavior as a function of environmental parameters. Based on these analyses, pertinent behavioral information relevant to bridge management is autonomously extracted.

  9. Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells

    PubMed Central

    Nguyen, Thuy Vy; Riou, Lydia

    2014-01-01

    Fanconi anemia is a rare genetic disorder that can lead to bone marrow failure, congenital abnormalities, and increased risk for leukemia and cancer. Cells with loss-of-function mutations in the FANC pathway are characterized by chromosome fragility, altered mutability, and abnormal regulation of the nonhomologous end-joining (NHEJ) pathway. Somatic hypermutation (SHM) and immunoglobulin (Ig) class switch recombination (CSR) enable B cells to produce high-affinity antibodies of various isotypes. Both processes are initiated after the generation of dG:dU mismatches by activation-induced cytidine deaminase. Whereas SHM involves an error-prone repair process that introduces novel point mutations into the Ig gene, the mismatches generated during CSR are processed to create double-stranded breaks (DSBs) in DNA, which are then repaired by the NHEJ pathway. As several lines of evidence suggest a possible role for the FANC pathway in SHM and CSR, we analyzed both processes in B cells derived from Fanca−/− mice. Here we show that Fanca is required for the induction of transition mutations at A/T residues during SHM and that despite globally normal CSR function in splenic B cells, Fanca is required during CSR to stabilize duplexes between pairs of short microhomology regions, thereby impeding short-range recombination downstream of DSB formation. PMID:24799500

  10. Fanca deficiency reduces A/T transitions in somatic hypermutation and alters class switch recombination junctions in mouse B cells.

    PubMed

    Nguyen, Thuy Vy; Riou, Lydia; Aoufouchi, Saïd; Rosselli, Filippo

    2014-06-02

    Fanconi anemia is a rare genetic disorder that can lead to bone marrow failure, congenital abnormalities, and increased risk for leukemia and cancer. Cells with loss-of-function mutations in the FANC pathway are characterized by chromosome fragility, altered mutability, and abnormal regulation of the nonhomologous end-joining (NHEJ) pathway. Somatic hypermutation (SHM) and immunoglobulin (Ig) class switch recombination (CSR) enable B cells to produce high-affinity antibodies of various isotypes. Both processes are initiated after the generation of dG:dU mismatches by activation-induced cytidine deaminase. Whereas SHM involves an error-prone repair process that introduces novel point mutations into the Ig gene, the mismatches generated during CSR are processed to create double-stranded breaks (DSBs) in DNA, which are then repaired by the NHEJ pathway. As several lines of evidence suggest a possible role for the FANC pathway in SHM and CSR, we analyzed both processes in B cells derived from Fanca(-/-) mice. Here we show that Fanca is required for the induction of transition mutations at A/T residues during SHM and that despite globally normal CSR function in splenic B cells, Fanca is required during CSR to stabilize duplexes between pairs of short microhomology regions, thereby impeding short-range recombination downstream of DSB formation. © 2014 Nguyen et al.

  11. An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling

    PubMed Central

    Sciammas, Roger; Li, Ying; Warmflash, Aryeh; Song, Yiqiang; Dinner, Aaron R; Singh, Harinder

    2011-01-01

    The B-lymphocyte lineage is a leading system for analyzing gene regulatory networks (GRNs) that orchestrate distinct cell fate transitions. Upon antigen recognition, B cells can diversify their immunoglobulin (Ig) repertoire via somatic hypermutation (SHM) and/or class switch DNA recombination (CSR) before differentiating into antibody-secreting plasma cells. We construct a mathematical model for a GRN underlying this developmental dynamic. The intensity of signaling through the Ig receptor is shown to control the bimodal expression of a pivotal transcription factor, IRF-4, which dictates B cell fate outcomes. Computational modeling coupled with experimental analysis supports a model of ‘kinetic control', in which B cell developmental trajectories pass through an obligate transient state of variable duration that promotes diversification of the antibody repertoire by SHM/CSR in direct response to antigens. More generally, this network motif could be used to translate a morphogen gradient into developmental inductive events of varying time, thereby enabling the specification of distinct cell fates. PMID:21613984

  12. A Data-Driven Diagnostic Framework for Wind Turbine Structures: A Holistic Approach

    PubMed Central

    Bogoevska, Simona; Spiridonakos, Minas; Chatzi, Eleni; Dumova-Jovanoska, Elena; Höffer, Rudiger

    2017-01-01

    The complex dynamics of operational wind turbine (WT) structures challenges the applicability of existing structural health monitoring (SHM) strategies for condition assessment. At the center of Europe’s renewable energy strategic planning, WT systems call for implementation of strategies that may describe the WT behavior in its complete operational spectrum. The framework proposed in this paper relies on the symbiotic treatment of acting environmental/operational variables and the monitored vibration response of the structure. The approach aims at accurate simulation of the temporal variability characterizing the WT dynamics, and subsequently at the tracking of the evolution of this variability in a longer-term horizon. The bi-component analysis tool is applied on long-term data, collected as part of continuous monitoring campaigns on two actual operating WT structures located in different sites in Germany. The obtained data-driven structural models verify the potential of the proposed strategy for development of an automated SHM diagnostic tool. PMID:28358346

  13. [Interior] Configuration options, habitability and architectural aspects of the transfer habitat module (THM) and the surface habitat on Mars (SHM)/ESA's AURORA human mission to Mars (HMM) study

    NASA Astrophysics Data System (ADS)

    Imhof, Barbara

    2007-02-01

    This paper discusses the findings for [Interior] configuration options, habitability and architectural aspects of a first human spacecraft to Mars. In 2003 the space architecture office LIQUIFER was invited by the European Space Agency's (ESA) AURORA Program committee to consult the scientists and engineers from the European Space and Technology Center (ESTEC) and other European industrial communities with developing the first human mission to Mars, which will take place in 2030, regarding the architectural issues of crewed habitats. The task was to develop an interior configuration for a transfer vehicle (TV) to Mars, especially a transfer habitation module (THM) and a surface habitat module (SHM) on Mars. The total travel time Earth—Mars and back for a crew of six amounts to approximately 900 days. After a 200-day-flight three crewmembers will land on Mars in the Mars excursion vehicle (MEV) and will live and work in the SHM for 30 days. For 500 days before the 200-day journey back the spacecraft continues to circle the Martian orbit for further exploration. The entire mission program is based on our present knowledge of technology. The project was compiled during a constant feedback-design process and trans-disciplinary collaboration sessions in the ESA-ESTEC concurrent design facility. Long-term human space flight sets new spatial conditions and requirements to the design concept. The guidelines were developed from relevant numbers and facts of recognized standards, interviews with astronauts/cosmonauts and from analyses about habitability, sociology, psychology and configuration concepts of earlier space stations in combination with the topics of the individual's perception and relation of space. Result of this study is the development of a prototype concept for the THM and SHM with detailed information and complete plans of the interior configuration, including mass calculations. In addition the study contains a detailed explanation of the development of the Design process including all suggested design and configuration options.

  14. Regulation of Aicda expression and AID activity

    PubMed Central

    ZAN, HONG; CASALI, PAOLO

    2013-01-01

    Activation-induced cytidine deaminase (AID) is expressed in a B cell differentiation stage-specific fashion and is essential for immunoglobulin (Ig) gene class switch DNA recombination (CSR) and somatic hypermutation (SHM). CSR and SHM play a central role in the maturation of antibody and autoantibody responses. AID displays a mutagenic activity by catalyzing targeted deamination of deoxycytidine (dC) residues in DNA resulting in dU:dG mismatches, which are processed into point-mutations in SHM or double-strand breaks (DSBs) in CSR. Although AID specifically targets the Ig gene loci (IgH, Igκ and Igλ), it can also home into a wide array of non-Ig genes in B- and non-B-cell backgrounds. Aberrant expression of AID is associated with multiple diseases such as allergy, inflammation, autoimmunity and cancer. In autoimmune systemic lupus erythematosus, dysregulated AID expression underpins increased CSR, SHM and autoantibody production. As a potent mutator, AID is under stringent transcriptional, post-transcriptional and post-translational regulation. AID is also regulated in its targeting and enzymatic function. In resting naïve or memory B cells, AID transcripts and protein are undetectable. These, however, are readily and significantly upregulated in B cells induced to undergo CSR and/or SHM. Transcription factors, such as HoxC4 and NF-κB, which are upregulated in a B cell lineage- and/or differentiation stage-specific manner, regulate the induction of AID. HoxC4 induces AID expression by directly binding to the AID gene promoter through an evolutionarily conserved 5’-ATTT-3’ motif. HoxC4 is induced by the same stimuli that induce AID and CSR. It is further upregulated by estrogen through three estrogen responsive elements in its promoter region. The targeting of AID to switch (S) regions is mediated by 14-3-3 adaptor proteins, which specifically bind to 5′-AGCT-3′ repeats that are exist at high frequency in S region cores. Like HoxC4, 14-3-3 adaptors are induced by the same stimuli that induce AID. These include “primary” inducing stimuli, that is, those that play a major role in inducing AID, i.e., engagement of CD40 by CD154, engagement of Toll-like receptors (TLRs) by microbial-associated molecular patterns (MAMPs) and cross-linking of the BCR, as synergized by “secondary” inducing stimuli, that is, those that synergize for AID induction and specify CSR to different isotypes, i.e., switch-directing cytokines IL-4, TGF-β or IFN-γ. In this review, we focus on the multi-levels regulation of AID expression and activity. We also discuss the dysregulation or misexpression of AID in autoimmunity and tumorigenesis. PMID:23181381

  15. Best Practices for Evaluating the Capability of Nondestructive Evaluation (NDE) and Structural Health Monitoring (SHM) Techniques for Damage Characterization (Post-Print)

    DTIC Science & Technology

    2016-02-10

    a wide range of part, environmental and damage conditions. Best practices of using models are presented for both an eddy current NDE sizing and...to assess the reliability of NDE and SHM characterization capability. Best practices of using models are presented for both an eddy current NDE... EDDY CURRENT NDE CASE STUDY An eddy current crack sizing case study is presented to highlight examples of some of these complex characteristics of

  16. Distributed Stress Sensing and Non-Destructive Tests Using Mechanoluminescence Materials

    NASA Astrophysics Data System (ADS)

    Rahimi, Mohammad Reza

    Rapid aging of infrastructure systems is currently pervasive in the US and the anticipated cost until 2020 for rehabilitation of aging lifeline will reach 3.6 trillion US dollars (ASCE 2013). Reliable condition or serviceability assessment is critically important in decision-making for economic and timely maintenance of the infrastructure systems. Advanced sensors and nondestructive test (NDT) methods are the key technologies for structural health monitoring (SHM) applications that can provide information on the current state of structures. There are many traditional sensors and NDT methods, for examples, strain gauges, ultrasound, radiography and other X-ray, etc. to detect any defect on the infrastructure. Considering that civil infrastructure is typically large-scale and exhibits complex behavior, estimation of structural conditions by the local sensing and NDT methods is a challenging task. Non-contact and distributed (or full-field) sensing and NDT method are desirable that can provide rich information on the civil infrastructure's state. Materials with the ability of emitting light, especially in the visible range, are named as luminescent materials. Mechanoluminescence (ML) phenomenon is the light emission from luminescent materials as a response of an induced mechanical stress. ML materials offer new opportunities for SHM that can directly visualize the stress and crack distributions on the surface of structures through ML light emission. Although material research for ML phenomena have been made substantially, applications of the ML sensors to full-field stress and crack visualization are still at infant stage and have yet to be full-fledged. Moreover, practical applications of the ML sensors for SHM of civil infrastructure have difficulties since numerous challenging problems (e.g. environmental effect) arise in actual applications. In order to realize a practical SHM system employing ML sensors, more research needs to be conducted, for examples, fundamental understandings of physics of ML phenomenon, method for quantitative stress measurements, calibration method for ML sensors, improvement of sensitivity, optimal manufacturing and design of ML sensors, environmental effects of ML phenomenon (e.g. temperature), image processing and analysis, etc. In this research, fundamental ML phenomena of two most promising ML sensing materials were experimentally studied and a methodology for full-field quantitative strain measurements, for the first time, was proposed along with a standardized calibration method. Characteristics and behavior of ML composites and thin films coated on the structure have been studied under various material tests including compression, tension, pure shear, bending, etc. In addition, ML emission sensitivity to the manufacturing parameters and experimental conditions was addressed in order to find optimal design the ML sensor. A phenomenological stress-optics transduction model for predicting the ML light intensity from a thin-film ML coating sensor subjected to in-plane stresses was proposed. A new full-field quantitative strain measuring methodology by ML thin film sensor was developed, for the first time, in order to visualize and measure the strain field. The results from the ML sensor were compared and verified by finite element simulation results. For NDT applications of ML sensors, experimental tests were conducted to visualize the cracks on structural surfaces and detect damages on structural components. In summary, this research proposes and realizes a new distributed stress sensor and NDT method using ML sensing materials. The proposed method is experimentally validated to be effective for stress measurement and crack visualizations. Successful completion of this research provides a leap toward a commercial light intensity-based optic sensor to be used as a new full-field stress measurement technology and NDT method.

  17. Convergent Transcription At Intragenic Super-Enhancers Targets AID-initiated Genomic Instability

    PubMed Central

    Meng, Fei-Long; Du, Zhou; Federation, Alexander; Hu, Jiazhi; Wang, Qiao; Kieffer-Kwon, Kyong-Rim; Meyers, Robin M.; Amor, Corina; Wasserman, Caitlyn R.; Neuberg, Donna; Casellas, Rafael; Nussenzweig, Michel C.; Bradner, James E.; Liu, X. Shirley; Alt, Frederick W.

    2015-01-01

    Summary Activation-induced cytidine deaminase (AID) initiates both somatic hypermutation (SHM) for antibody affinity maturation and DNA breakage for antibody class switch recombination (CSR) via transcription-dependent cytidine deamination of single stranded DNA targets. While largely specific for immunoglobulin genes, AID also acts on a limited set of off-targets, generating oncogenic translocations and mutations that contribute to B cell lymphoma. How AID is recruited to off-targets has been a long-standing mystery. Based on deep GRO-Seq studies of mouse and human B lineage cells activated for CSR or SHM, we report that most robust AID off-target translocations occur within highly focal regions of target genes in which sense and antisense transcription converge. Moreover, we found that such AID-targeting “convergent” transcription arises from antisense transcription that emanates from Super-Enhancers within sense transcribed gene bodies. Our findings provide an explanation for AID off-targeting to a small subset of mostly lineage-specific genes in activated B cells. PMID:25483776

  18. A review on bridge dynamic displacement monitoring using global positioning system and accelerometer

    NASA Astrophysics Data System (ADS)

    Yunus, Mohd Zulkifli Mohd; Ibrahim, Nuremira; Ahmad, Fatimah Shafinaz

    2018-02-01

    This paper reviews previous research on bridge dynamic displacement monitoring using Global Positioning System (GPS) and an accelerometer for Structural Health Monitoring (SHM) of bridge. These include the review of the advantages and disadvantages of the measurement as well as the methodology of the measurements used in the recent research study. This review could provide a preliminary decision overview for students or researchers before initiating a research related to the bridge dynamic displacement monitoring.

  19. Next generation control system for reflexive aerostructures

    NASA Astrophysics Data System (ADS)

    Maddux, Michael R.; Meents, Elizabeth P.; Barnell, Thomas J.; Cable, Kristin M.; Hemmelgarn, Christopher; Margraf, Thomas W.; Havens, Ernie

    2010-04-01

    Cornerstone Research Group Inc. (CRG) has developed and demonstrated a composite structural solution called reflexive composites for aerospace applications featuring CRG's healable shape memory polymer (SMP) matrix. In reflexive composites, an integrated structural health monitoring (SHM) system autonomously monitors the structural health of composite aerospace structures, while integrated intelligent controls monitor data from the SHM system to characterize damage and initiate healing when damage is detected. Development of next generation intelligent controls for reflexive composites were initiated for the purpose of integrating prognostic health monitoring capabilities into the reflexive composite structural solution. Initial efforts involved data generation through physical inspections and mechanical testing. Compression after impact (CAI) testing was conducted on composite-reinforced shape memory polymer samples to induce damage and investigate the effectiveness of matrix healing on mechanical performance. Non-destructive evaluation (NDE) techniques were employed to observe and characterize material damage. Restoration of mechanical performance was demonstrated through healing, while NDE data showed location and size of damage and verified mitigation of damage post-healing. Data generated was used in the development of next generation reflexive controls software. Data output from the intelligent controls could serve as input to Integrated Vehicle Health Management (IVHM) systems and Integrated Resilient Aircraft Controls (IRAC). Reflexive composite technology has the ability to reduce maintenance required on composite structures through healing, offering potential to significantly extend service life of aerospace vehicles and reduce operating and lifecycle costs.

  20. 3D sensor placement strategy using the full-range pheromone ant colony system

    NASA Astrophysics Data System (ADS)

    Shuo, Feng; Jingqing, Jia

    2016-07-01

    An optimized sensor placement strategy will be extremely beneficial to ensure the safety and cost reduction considerations of structural health monitoring (SHM) systems. The sensors must be placed such that important dynamic information is obtained and the number of sensors is minimized. The practice is to select individual sensor directions by several 1D sensor methods and the triaxial sensors are placed in these directions for monitoring. However, this may lead to non-optimal placement of many triaxial sensors. In this paper, a new method, called FRPACS, is proposed based on the ant colony system (ACS) to solve the optimal placement of triaxial sensors. The triaxial sensors are placed as single units in an optimal fashion. And then the new method is compared with other algorithms using Dalian North Bridge. The computational precision and iteration efficiency of the FRPACS has been greatly improved compared with the original ACS and EFI method.

  1. AID-initiated purposeful mutations in immunoglobulin genes.

    PubMed

    Goodman, Myron F; Scharff, Matthew D; Romesberg, Floyd E

    2007-01-01

    Exposure brings risk to all living organisms. Using a remarkably effective strategy, higher vertebrates mitigate risk by mounting a complex and sophisticated immune response to counter the potentially toxic invasion by a virtually limitless army of chemical and biological antagonists. Mutations are almost always deleterious, but in the case of antibody diversification there are mutations occurring at hugely elevated rates within the variable (V) and switch regions (SR) of the immunoglobulin (Ig) genes that are responsible for binding to and neutralizing foreign antigens throughout the body. These mutations are truly purposeful. This chapter is centered on activation-induced cytidine deaminase (AID). AID is required for initiating somatic hypermutation (SHM) in the V regions and class switch recombination (CSR) in the SR portions of Ig genes. By converting C --> U, while transcription takes place, AID instigates a cascade of mutational events involving error-prone DNA polymerases, base excision and mismatch repair enzymes, and recombination pathways. Together, these processes culminate in highly mutated antibody genes and the B cells expressing antibodies that have achieved optimal antigenic binding undergo positive selection in germinal centers. We will discuss the biological role of AID in this complex process, primarily in terms of its biochemical properties in relation to SHM in vivo. The chapter also discusses recent advances in experimental methods to characterize antibody dynamics as a function of SHM to help elucidate the role that the AID-induced mutations play in tailoring molecular recognition. The emerging experimental techniques help to address long-standing conundrums concerning evolution-imposed constraints on antibody structure and function.

  2. Autonomous smart sensor network for full-scale structural health monitoring

    NASA Astrophysics Data System (ADS)

    Rice, Jennifer A.; Mechitov, Kirill A.; Spencer, B. F., Jr.; Agha, Gul A.

    2010-04-01

    The demands of aging infrastructure require effective methods for structural monitoring and maintenance. Wireless smart sensor networks offer the ability to enhance structural health monitoring (SHM) practices through the utilization of onboard computation to achieve distributed data management. Such an approach is scalable to the large number of sensor nodes required for high-fidelity modal analysis and damage detection. While smart sensor technology is not new, the number of full-scale SHM applications has been limited. This slow progress is due, in part, to the complex network management issues that arise when moving from a laboratory setting to a full-scale monitoring implementation. This paper presents flexible network management software that enables continuous and autonomous operation of wireless smart sensor networks for full-scale SHM applications. The software components combine sleep/wake cycling for enhanced power management with threshold detection for triggering network wide tasks, such as synchronized sensing or decentralized modal analysis, during periods of critical structural response.

  3. Phase Space Dissimilarity Measures for Structural Health Monitoring

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bubacz, Jacob A; Chmielewski, Hana T; Pape, Alexander E

    A novel method for structural health monitoring (SHM), known as the Phase Space Dissimilarity Measures (PSDM) approach, is proposed and developed. The patented PSDM approach has already been developed and demonstrated for a variety of equipment and biomedical applications. Here, we investigate SHM of bridges via analysis of time serial accelerometer measurements. This work has four aspects. The first is algorithm scalability, which was found to scale linearly from one processing core to four cores. Second, the same data are analyzed to determine how the use of the PSDM approach affects sensor placement. We found that a relatively low-density placementmore » sufficiently captures the dynamics of the structure. Third, the same data are analyzed by unique combinations of accelerometer axes (vertical, longitudinal, and lateral with respect to the bridge) to determine how the choice of axes affects the analysis. The vertical axis is found to provide satisfactory SHM data. Fourth, statistical methods were investigated to validate the PSDM approach for this application, yielding statistically significant results.« less

  4. Immunoglobulin class-switch recombination deficiencies.

    PubMed

    Durandy, Anne; Kracker, Sven

    2012-07-30

    Immunoglobulin class-switch recombination deficiencies (Ig-CSR-Ds) are rare primary immunodeficiencies characterized by defective switched isotype (IgG/IgA/IgE) production. Depending on the molecular defect in question, the Ig-CSR-D may be combined with an impairment in somatic hypermutation (SHM). Some of the mechanisms underlying Ig-CSR and SHM have been described by studying natural mutants in humans. This approach has revealed that T cell-B cell interaction (resulting in CD40-mediated signaling), intrinsic B-cell mechanisms (activation-induced cytidine deaminase-induced DNA damage), and complex DNA repair machineries (including uracil-N-glycosylase and mismatch repair pathways) are all involved in class-switch recombination and SHM. However, several of the mechanisms required for full antibody maturation have yet to be defined. Elucidation of the molecular defects underlying the diverse set of Ig-CSR-Ds is essential for understanding Ig diversification and has prompted better definition of the clinical spectrum of diseases and the development of increasingly accurate diagnostic and therapeutic approaches.

  5. Immunoglobulin class-switch recombination deficiencies

    PubMed Central

    2012-01-01

    Immunoglobulin class-switch recombination deficiencies (Ig-CSR-Ds) are rare primary immunodeficiencies characterized by defective switched isotype (IgG/IgA/IgE) production. Depending on the molecular defect in question, the Ig-CSR-D may be combined with an impairment in somatic hypermutation (SHM). Some of the mechanisms underlying Ig-CSR and SHM have been described by studying natural mutants in humans. This approach has revealed that T cell-B cell interaction (resulting in CD40-mediated signaling), intrinsic B-cell mechanisms (activation-induced cytidine deaminase-induced DNA damage), and complex DNA repair machineries (including uracil-N-glycosylase and mismatch repair pathways) are all involved in class-switch recombination and SHM. However, several of the mechanisms required for full antibody maturation have yet to be defined. Elucidation of the molecular defects underlying the diverse set of Ig-CSR-Ds is essential for understanding Ig diversification and has prompted better definition of the clinical spectrum of diseases and the development of increasingly accurate diagnostic and therapeutic approaches. PMID:22894609

  6. Vibration-based structural health monitoring of the aircraft large component

    NASA Astrophysics Data System (ADS)

    Pavelko, V.; Kuznetsov, S.; Nevsky, A.; Marinbah, M.

    2017-10-01

    In the presented paper there are investigated the basic problems of the local system of SHM of large scale aircraft component. Vibration-based damage detection is accepted as a basic condition, and main attention focused to a low-cost solution that would be attractive for practice. The conditions of small damage detection in the full scale structural component at low-frequency excitation were defined in analytical study and modal FEA. In experimental study the dynamic test of the helicopter Mi-8 tail beam was performed at harmonic excitation with frequency close to first natural frequency of the beam. The index of correlation coefficient deviation (CCD) was used for extraction of the features due to embedded pseudo-damage. It is shown that the problem of vibration-based detection of a small damage in the large scale structure at low-frequency excitation can be solved successfully.

  7. Applications of a nanocomposite-inspired in-situ broadband ultrasonic sensor to acousto-ultrasonics-based passive and active structural health monitoring.

    PubMed

    Liu, Menglong; Zeng, Zhihui; Xu, Hao; Liao, Yaozhong; Zhou, Limin; Zhang, Zhong; Su, Zhongqing

    2017-07-01

    A novel nanocomposite-inspired in-situ broadband ultrasonic sensor previously developed, with carbon black as the nanofiller and polyvinylidene fluoride as the matrix, was networked for acousto-ultrasonic wave-based passive and active structural health monitoring (SHM). Being lightweight and small, this kind of sensor was proven to be capable of perceiving strain perturbation in virtue of the tunneling effect in the formed nanofiller conductive network when acousto-ultrasonic waves traverse the sensor. Proof-of-concept validation was implemented, to examine the sensor performance in responding to acousto-ultrasonic waves in a broad frequency regime: from acoustic emission (AE) of lower frequencies to guided ultrasonic waves (GUWs) of higher frequencies. Results have demonstrated the high fidelity, ultrafast response and high sensitivity of the sensor to acousto-ultrasonic waves up to 400kHz yet with an ultra-low magnitude (of the order of micro-strain). The sensor is proven to possess sensitivity and accuracy comparable with commercial piezoelectric ultrasonic transducers, whereas with greater flexibility in accommodating curved structural surfaces. Application paradigms of using the sensor for damage evaluation have spotlighted the capability of the sensor in compromising "sensing cost" with "sensing effectiveness" for passive AE- or active GUW-based SHM. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Data driven innovations in structural health monitoring

    NASA Astrophysics Data System (ADS)

    Rosales, M. J.; Liyanapathirana, R.

    2017-05-01

    At present, substantial investments are being allocated to civil infrastructures also considered as valuable assets at a national or global scale. Structural Health Monitoring (SHM) is an indispensable tool required to ensure the performance and safety of these structures based on measured response parameters. The research to date on damage assessment has tended to focus on the utilization of wireless sensor networks (WSN) as it proves to be the best alternative over the traditional visual inspections and tethered or wired counterparts. Over the last decade, the structural health and behaviour of innumerable infrastructure has been measured and evaluated owing to several successful ventures of implementing these sensor networks. Various monitoring systems have the capability to rapidly transmit, measure, and store large capacities of data. The amount of data collected from these networks have eventually been unmanageable which paved the way to other relevant issues such as data quality, relevance, re-use, and decision support. There is an increasing need to integrate new technologies in order to automate the evaluation processes as well as to enhance the objectivity of data assessment routines. This paper aims to identify feasible methodologies towards the application of time-series analysis techniques to judiciously exploit the vast amount of readily available as well as the upcoming data resources. It continues the momentum of a greater effort to collect and archive SHM approaches that will serve as data-driven innovations for the assessment of damage through efficient algorithms and data analytics.

  9. Combination of digital signal processing methods towards an improved analysis algorithm for structural health monitoring.

    NASA Astrophysics Data System (ADS)

    Pentaris, Fragkiskos P.; Makris, John P.

    2013-04-01

    In Structural Health Monitoring (SHM) is of great importance to reveal valuable information from the recorded SHM data that could be used to predict or indicate structural fault or damage in a building. In this work a combination of digital signal processing methods, namely FFT along with Wavelet Transform is applied, together with a proposed algorithm to study frequency dispersion, in order to depict non-linear characteristics of SHM data collected in two university buildings under natural or anthropogenic excitation. The selected buildings are of great importance from civil protection point of view, as there are the premises of a public higher education institute, undergoing high use, stress, visit from academic staff and students. The SHM data are collected from two neighboring buildings that have different age (4 and 18 years old respectively). Proposed digital signal processing methods are applied to the data, presenting a comparison of the structural behavior of both buildings in response to seismic activity, weather conditions and man-made activity. Acknowledgments This work was supported in part by the Archimedes III Program of the Ministry of Education of Greece, through the Operational Program "Educational and Lifelong Learning", in the framework of the project entitled «Interdisciplinary Multi-Scale Research of Earthquake Physics and Seismotectonics at the front of the Hellenic Arc (IMPACT-ARC) » and is co-financed by the European Union (European Social Fund) and Greek National Fund.

  10. Numerical simulation and experimental validation of Lamb wave propagation behavior in composite plates

    NASA Astrophysics Data System (ADS)

    Kim, Sungwon; Uprety, Bibhisha; Mathews, V. John; Adams, Daniel O.

    2015-03-01

    Structural Health Monitoring (SHM) based on Acoustic Emission (AE) is dependent on both the sensors to detect an impact event as well as an algorithm to determine the impact location. The propagation of Lamb waves produced by an impact event in thin composite structures is affected by several unique aspects including material anisotropy, ply orientations, and geometric discontinuities within the structure. The development of accurate numerical models of Lamb wave propagation has important benefits towards the development of AE-based SHM systems for impact location estimation. Currently, many impact location algorithms utilize the time of arrival or velocities of Lamb waves. Therefore the numerical prediction of characteristic wave velocities is of great interest. Additionally, the propagation of the initial symmetric (S0) and asymmetric (A0) wave modes is important, as these wave modes are used for time of arrival estimation. In this investigation, finite element analyses were performed to investigate aspects of Lamb wave propagation in composite plates with active signal excitation. A comparative evaluation of two three-dimensional modeling approaches was performed, with emphasis placed on the propagation and velocity of both the S0 and A0 wave modes. Results from numerical simulations are compared to experimental results obtained from active AE testing. Of particular interest is the directional dependence of Lamb waves in quasi-isotropic carbon/epoxy composite plates. Numerical and experimental results suggest that although a quasi-isotropic composite plate may have the same effective elastic modulus in all in-plane directions, the Lamb wave velocity may have some directional dependence. Further numerical analyses were performed to investigate Lamb wave propagation associated with circular cutouts in composite plates.

  11. Nonlinear finite element model updating for damage identification of civil structures using batch Bayesian estimation

    NASA Astrophysics Data System (ADS)

    Ebrahimian, Hamed; Astroza, Rodrigo; Conte, Joel P.; de Callafon, Raymond A.

    2017-02-01

    This paper presents a framework for structural health monitoring (SHM) and damage identification of civil structures. This framework integrates advanced mechanics-based nonlinear finite element (FE) modeling and analysis techniques with a batch Bayesian estimation approach to estimate time-invariant model parameters used in the FE model of the structure of interest. The framework uses input excitation and dynamic response of the structure and updates a nonlinear FE model of the structure to minimize the discrepancies between predicted and measured response time histories. The updated FE model can then be interrogated to detect, localize, classify, and quantify the state of damage and predict the remaining useful life of the structure. As opposed to recursive estimation methods, in the batch Bayesian estimation approach, the entire time history of the input excitation and output response of the structure are used as a batch of data to estimate the FE model parameters through a number of iterations. In the case of non-informative prior, the batch Bayesian method leads to an extended maximum likelihood (ML) estimation method to estimate jointly time-invariant model parameters and the measurement noise amplitude. The extended ML estimation problem is solved efficiently using a gradient-based interior-point optimization algorithm. Gradient-based optimization algorithms require the FE response sensitivities with respect to the model parameters to be identified. The FE response sensitivities are computed accurately and efficiently using the direct differentiation method (DDM). The estimation uncertainties are evaluated based on the Cramer-Rao lower bound (CRLB) theorem by computing the exact Fisher Information matrix using the FE response sensitivities with respect to the model parameters. The accuracy of the proposed uncertainty quantification approach is verified using a sampling approach based on the unscented transformation. Two validation studies, based on realistic structural FE models of a bridge pier and a moment resisting steel frame, are performed to validate the performance and accuracy of the presented nonlinear FE model updating approach and demonstrate its application to SHM. These validation studies show the excellent performance of the proposed framework for SHM and damage identification even in the presence of high measurement noise and/or way-out initial estimates of the model parameters. Furthermore, the detrimental effects of the input measurement noise on the performance of the proposed framework are illustrated and quantified through one of the validation studies.

  12. Acid-base and copper-binding properties of three organic matter fractions isolated from a forest floor soil solution

    NASA Astrophysics Data System (ADS)

    van Schaik, Joris W. J.; Kleja, Dan B.; Gustafsson, Jon Petter

    2010-02-01

    Vast amounts of knowledge about the proton- and metal-binding properties of dissolved organic matter (DOM) in natural waters have been obtained in studies on isolated humic and fulvic (hydrophobic) acids. Although macromolecular hydrophilic acids normally make up about one-third of DOM, their proton- and metal-binding properties are poorly known. Here, we investigated the acid-base and Cu-binding properties of the hydrophobic (fulvic) acid fraction and two hydrophilic fractions isolated from a soil solution. Proton titrations revealed a higher total charge for the hydrophilic acid fractions than for the hydrophobic acid fraction. The most hydrophilic fraction appeared to be dominated by weak acid sites, as evidenced by increased slope of the curve of surface charge versus pH at pH values above 6. The titration curves were poorly predicted by both Stockholm Humic Model (SHM) and NICA-Donnan model calculations using generic parameter values, but could be modelled accurately after optimisation of the proton-binding parameters (pH ⩽ 9). Cu-binding isotherms for the three fractions were determined at pH values of 4, 6 and 9. With the optimised proton-binding parameters, the SHM model predictions for Cu binding improved, whereas the NICA-Donnan predictions deteriorated. After optimisation of Cu-binding parameters, both models described the experimental data satisfactorily. Iron(III) and aluminium competed strongly with Cu for binding sites at both pH 4 and pH 6. The SHM model predicted this competition reasonably well, but the NICA-Donnan model underestimated the effects significantly at pH 6. Overall, the Cu-binding behaviour of the two hydrophilic acid fractions was very similar to that of the hydrophobic acid fraction, despite the differences observed in proton-binding characteristics. These results show that for modelling purposes, it is essential to include the hydrophilic acid fraction in the pool of 'active' humic substances.

  13. Features of Cross-Correlation Analysis in a Data-Driven Approach for Structural Damage Assessment

    PubMed Central

    Camacho Navarro, Jhonatan; Ruiz, Magda; Villamizar, Rodolfo; Mujica, Luis

    2018-01-01

    This work discusses the advantage of using cross-correlation analysis in a data-driven approach based on principal component analysis (PCA) and piezodiagnostics to obtain successful diagnosis of events in structural health monitoring (SHM). In this sense, the identification of noisy data and outliers, as well as the management of data cleansing stages can be facilitated through the implementation of a preprocessing stage based on cross-correlation functions. Additionally, this work evidences an improvement in damage detection when the cross-correlation is included as part of the whole damage assessment approach. The proposed methodology is validated by processing data measurements from piezoelectric devices (PZT), which are used in a piezodiagnostics approach based on PCA and baseline modeling. Thus, the influence of cross-correlation analysis used in the preprocessing stage is evaluated for damage detection by means of statistical plots and self-organizing maps. Three laboratory specimens were used as test structures in order to demonstrate the validity of the methodology: (i) a carbon steel pipe section with leak and mass damage types, (ii) an aircraft wing specimen, and (iii) a blade of a commercial aircraft turbine, where damages are specified as mass-added. As the main concluding remark, the suitability of cross-correlation features combined with a PCA-based piezodiagnostic approach in order to achieve a more robust damage assessment algorithm is verified for SHM tasks. PMID:29762505

  14. Features of Cross-Correlation Analysis in a Data-Driven Approach for Structural Damage Assessment.

    PubMed

    Camacho Navarro, Jhonatan; Ruiz, Magda; Villamizar, Rodolfo; Mujica, Luis; Quiroga, Jabid

    2018-05-15

    This work discusses the advantage of using cross-correlation analysis in a data-driven approach based on principal component analysis (PCA) and piezodiagnostics to obtain successful diagnosis of events in structural health monitoring (SHM). In this sense, the identification of noisy data and outliers, as well as the management of data cleansing stages can be facilitated through the implementation of a preprocessing stage based on cross-correlation functions. Additionally, this work evidences an improvement in damage detection when the cross-correlation is included as part of the whole damage assessment approach. The proposed methodology is validated by processing data measurements from piezoelectric devices (PZT), which are used in a piezodiagnostics approach based on PCA and baseline modeling. Thus, the influence of cross-correlation analysis used in the preprocessing stage is evaluated for damage detection by means of statistical plots and self-organizing maps. Three laboratory specimens were used as test structures in order to demonstrate the validity of the methodology: (i) a carbon steel pipe section with leak and mass damage types, (ii) an aircraft wing specimen, and (iii) a blade of a commercial aircraft turbine, where damages are specified as mass-added. As the main concluding remark, the suitability of cross-correlation features combined with a PCA-based piezodiagnostic approach in order to achieve a more robust damage assessment algorithm is verified for SHM tasks.

  15. Concept Development for Software Health Management

    NASA Technical Reports Server (NTRS)

    Riecks, Jung; Storm, Walter; Hollingsworth, Mark

    2011-01-01

    This report documents the work performed by Lockheed Martin Aeronautics (LM Aero) under NASA contract NNL06AA08B, delivery order NNL07AB06T. The Concept Development for Software Health Management (CDSHM) program was a NASA funded effort sponsored by the Integrated Vehicle Health Management Project, one of the four pillars of the NASA Aviation Safety Program. The CD-SHM program focused on defining a structured approach to software health management (SHM) through the development of a comprehensive failure taxonomy that is used to characterize the fundamental failure modes of safety-critical software.

  16. Structural Analysis Methods for Structural Health Management of Future Aerospace Vehicles

    NASA Technical Reports Server (NTRS)

    Tessler, Alexander

    2007-01-01

    Two finite element based computational methods, Smoothing Element Analysis (SEA) and the inverse Finite Element Method (iFEM), are reviewed, and examples of their use for structural health monitoring are discussed. Due to their versatility, robustness, and computational efficiency, the methods are well suited for real-time structural health monitoring of future space vehicles, large space structures, and habitats. The methods may be effectively employed to enable real-time processing of sensing information, specifically for identifying three-dimensional deformed structural shapes as well as the internal loads. In addition, they may be used in conjunction with evolutionary algorithms to design optimally distributed sensors. These computational tools have demonstrated substantial promise for utilization in future Structural Health Management (SHM) systems.

  17. Tapered Polymer Fiber Sensors for Reinforced Concrete Beam Vibration Detection.

    PubMed

    Luo, Dong; Ibrahim, Zainah; Ma, Jianxun; Ismail, Zubaidah; Iseley, David Thomas

    2016-12-16

    In this study, tapered polymer fiber sensors (TPFSs) have been employed to detect the vibration of a reinforced concrete beam (RC beam). The sensing principle was based on transmission modes theory. The natural frequency of an RC beam was theoretically analyzed. Experiments were carried out with sensors mounted on the surface or embedded in the RC beam. Vibration detection results agreed well with Kistler accelerometers. The experimental results found that both the accelerometer and TPFS detected the natural frequency function of a vibrated RC beam well. The mode shapes of the RC beam were also found by using the TPFSs. The proposed vibration detection method provides a cost-comparable solution for a structural health monitoring (SHM) system in civil engineering.

  18. Tapered Polymer Fiber Sensors for Reinforced Concrete Beam Vibration Detection

    PubMed Central

    Luo, Dong; Ibrahim, Zainah; Ma, Jianxun; Ismail, Zubaidah; Iseley, David Thomas

    2016-01-01

    In this study, tapered polymer fiber sensors (TPFSs) have been employed to detect the vibration of a reinforced concrete beam (RC beam). The sensing principle was based on transmission modes theory. The natural frequency of an RC beam was theoretically analyzed. Experiments were carried out with sensors mounted on the surface or embedded in the RC beam. Vibration detection results agreed well with Kistler accelerometers. The experimental results found that both the accelerometer and TPFS detected the natural frequency function of a vibrated RC beam well. The mode shapes of the RC beam were also found by using the TPFSs. The proposed vibration detection method provides a cost-comparable solution for a structural health monitoring (SHM) system in civil engineering. PMID:27999245

  19. Principles in wireless building health monitoring systems.

    NASA Astrophysics Data System (ADS)

    Pentaris, F. P.; Makris, J. P.; Stonham, J.; Vallianatos, F.

    2012-04-01

    Monitoring the structural state of a building is essential for the safety of the people who work, live, visit or just use it as well as for the civil protection of urban areas. Many factors can affect the state of the health of a structure, namely man made, like mistakes in the construction, traffic, heavy loads on the structures, explosions, environmental impacts like wind loads, humidity, chemical reactions, temperature changes and saltiness, and natural hazards like earthquakes and landslides. Monitoring the health of a structure provides the ability to anticipate structural failures and secure the safe use of buildings especially those of public services. This work reviews the state of the art and the challenges of a wireless Structural Health Monitoring (WiSHM). Literature review reveals that although there is significant evolution in wireless structural health monitoring, in many cases, monitoring by itself is not enough to predict when a structure becomes inappropriate and/or unsafe for use, and the damage or low durability of a structure cannot be revealed (Chintalapudi, et al., 2006; Ramos, Aguilar, & Lourenço, 2011). Several features and specifications of WiSHM like wireless sensor networking, reliability and autonomy of sensors, algorithms of data transmission and analysis should still be evolved and improved in order to increase the predictive effectiveness of the SHM (Jinping Ou & Hui Li, 2010; Lu & Loh, 2010) . Acknowledgments This work was supported in part by the ARCHEMEDES III Program of the Ministry of Education of Greece and the European Union in the framework of the project entitled «Interdisciplinary Multi-Scale Research of Earthquake Physics and Seismotectonics at the front of the Hellenic Arc (IMPACT-ARC) ».

  20. Sampling considerations for modal analysis with damping

    NASA Astrophysics Data System (ADS)

    Park, Jae Young; Wakin, Michael B.; Gilbert, Anna C.

    2015-03-01

    Structural health monitoring (SHM) systems are critical for monitoring aging infrastructure (such as buildings or bridges) in a cost-effective manner. Wireless sensor networks that sample vibration data over time are particularly appealing for SHM applications due to their flexibility and low cost. However, in order to extend the battery life of wireless sensor nodes, it is essential to minimize the amount of vibration data these sensors must collect and transmit. In recent work, we have studied the performance of the Singular Value Decomposition (SVD) applied to the collection of data and provided new finite sample analysis characterizing conditions under which this simple technique{also known as the Proper Orthogonal Decomposition (POD){can correctly estimate the mode shapes of the structure. Specifically, we provided theoretical guarantees on the number and duration of samples required in order to estimate a structure's mode shapes to a desired level of accuracy. In that previous work, however, we considered simplified Multiple-Degree-Of-Freedom (MDOF) systems with no damping. In this paper we consider MDOF systems with proportional damping and show that, with sufficiently light damping, the POD can continue to provide accurate estimates of a structure's mode shapes. We support our discussion with new analytical insight and experimental demonstrations. In particular, we study the tradeoffs between the level of damping, the sampling rate and duration, and the accuracy to which the structure's mode shapes can be estimated.

  1. Structural health monitoring system for bridges based on skin-like sensor

    NASA Astrophysics Data System (ADS)

    Loupos, Konstantinos; Damigos, Yannis; Amditis, Angelos; Gerhard, Reimund; Rychkov, Dmitry; Wirges, Werner; Schulze, Manuel; Lenas, Sotiris-Angelos; Chatziandreoglou, Christos; Malliou, Christina M.; Tsaoussidis, Vassilis; Brady, Ken; Frankenstein, Bernd

    2017-09-01

    Structural health monitoring activities are of primal importance for managing transport infrastructure, however most SHM methodologies are based on point-based sensors that have limitations in terms of their spatial positioning requirements, cost of development and measurement range. This paper describes the progress on the SENSKIN EC project whose objective is to develop a dielectric-elastomer and micro-electronics-based sensor, formed from a large highly extensible capacitance sensing membrane supported by advanced microelectronic circuitry, for monitoring transport infrastructure bridges. Such a sensor could provide spatial measurements of strain in excess of 10%. The actual sensor along with the data acquisition module, the communication module and power electronics are all integrated into a compact unit, the SENSKIN device, which is energy-efficient, requires simple signal processing and it is easy to install over various surface types. In terms of communication, SENSKIN devices interact with each other to form the SENSKIN system; a fully distributed and autonomous wireless sensor network that is able to self-monitor. SENSKIN system utilizes Delay-/Disruption-Tolerant Networking technologies to ensure that the strain measurements will be received by the base station even under extreme conditions where normal communications are disrupted. This paper describes the architecture of the SENSKIN system and the development and testing of the first SENSKIN prototype sensor, the data acquisition system, and the communication system.

  2. Silicone hydrogel mini-scleral contact lenses in early stage after corneal collagen cross-linking for keratoconus: a retrospective case series.

    PubMed

    Severinsky, Boris; Wajnsztajn, Denise; Frucht-Pery, Joseph

    2013-11-01

     The aim was to the evaluate performance of a novel silicone hydrogel mini-scleral contact lens (SHmS) for optical correction of keratoconus in the early stages after the corneal collagen cross-linking procedure (CXL).  We retrospectively analysed the visual acuity improvement and corneal adaptation in the first 10 eyes of nine patients fitted with SHmS lenses one to 3.5 months after corneal collagen cross-linking. The lenses were designed to rest over the patients' sclera and peri-limbal cornea and vault the central cornea with minimal support over it. Visual acuities with manifest refraction and contact lenses, refractive and topographical values (Kmin and Kmax) were evaluated on lens dispensing and after six month of lens wearing. Ocular physiological responses were evaluated using the Institute of Eye Research (IER) grading scales.  SHmS fitting was performed 2.1 ± 0.97 (SD) months after collagen cross-linking. Mean follow up was 10.9 ± 4.41 months (range six to 18 months). Mean decimal visual acuity with SHmS was 0.66 ± 0.22 (approximately 6/9 Snellen fraction, range 0.3 to 0.1) or 0.75 ± 0.14 (approximately 6/8.1, range 0.5 to 1.0), when omitting two amblyopic eyes. Nine (90 per cent) eyes were successfully fitted, that is, able to wear the lenses for 10 hours per day or longer. Mean wearing time was 11.7 hours (range six to 14) per day. No corneal neovascularisation or papillary reaction was found in all fitted eyes.  SHmS contact lenses provide successful visual rehabilitation shortly after corneal collagen cross-linking. This new soft contact lens design with scleral fixation and minimal apical touch was demonstrated to be safe shortly after collagen cross-linking, as the avoidance of contact with the treated zone minimises contact lens influence on corneal recovery. © 2013 The Authors. Clinical and Experimental Optometry © 2013 Optometrists Association Australia.

  3. The Single Habitat Module Concept a Streamlined Way to Explore

    NASA Technical Reports Server (NTRS)

    Chambliss, Joe

    2012-01-01

    Many concepts have been proposed for exploring space. In early 2010 presidential direction called for reconsidering the approach to address changes in exploration destinations, use of new technologies and development of new capabilities to support exploration of space. Considering the proposed new technologies and capabilities that NASA was directed to pursue, the Single Habitathabitat module (SHMSHM) concept for a more streamlined approach to the infrastructure and conduct of exploration missions was developed. The SHM concept combines many of the new promising technologies with a central concept of mission architectures that uses a single habitat module for all phases of an exploration mission. Integrating mission elements near Earth and fully fueling them prior to departure of the vicinity of Earth provides the capability of using the single habitat both in transit to an exploration destination and while exploring the destination. The concept employs the capability to return the habitat and interplanetary propulsion system to Earth vicinity so that those elements can be reused on subsequent exploration missions. This paper describes the SHM concept, and the advantages it provides to accomplish exploration objectives.

  4. Hot-Spot Fatigue and Impact Damage Detection on a Helicopter Tailboom

    DTIC Science & Technology

    2011-09-01

    other 14 PZT disks were used as sensors. Among the 28 PZT disks, 16 PZT disks were placed in the two fatigue hot-spot areas to detect cracks initiated...more efficient and effective airframe maintenance, fatigue cracking and impact damage detection technologies were developed and demonstrated on a...SHM system in successfully monitoring fatigue cracks initiated from cyclical loading conditions; detecting, locating and quantifying ballistic

  5. Structural health monitoring of compression connectors for overhead transmission lines

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Hong; Wang, Jy-An John; Swindeman, Joseph P

    Two-stage aluminum conductor steel-reinforced (ACSR) compression connectors are extensively used in US overhead transmission lines. The connectors are made by crimping a steel sleeve onto a steel core and an aluminum sleeve over aluminum conductive strands. The connectors are designed to operate at temperatures up to 125 C, but their performance is increasingly degrading because of overloading of lines. Currently, electric utilities conduct routine line inspections using thermal and electrical measurements. However, information about the structural integrity of connectors cannot be obtained. In this work, structural health monitoring (SHM) of compression connectors was studied using electromechanical impedance (EMI) analysis. Leadmore » zirconate titanate (PZT)-5A was identified as a smart material for SHM. A flexible high-temperature bonding layer was used to address challenges in PZT integration due to a significant difference in the coefficients of thermal expansion of PZT and the aluminum substrate. The steel joint on the steel core was investigated because it is responsible for the ultimate tensile strength of the connector. Tensile testing was used to create structural damage to the joint, or steel core pullout, and thermal cycling introduced additional structural perturbations. EMI measurements were conducted between the tests. The root mean square deviation (RMSD) of EMI was identified as a damage index. The use of steel joints has been shown to enable SHM under simulated conditions. The EMI signature is sensitive to variations in structural conditions. RMSD can be correlated to the structural health of a connector and has potential for use in the SHM and structural integrity evaluation.« less

  6. Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination.

    PubMed

    Li, Fubin; Yan, Yi; Pieretti, Joyce; Feldman, Danielle A; Eckhardt, Laurel A

    2010-11-15

    Somatic hypermutation (SHM), coupled with Ag selection, provides a mechanism for generating Abs with high affinity for invading pathogens. Class-switch recombination (CSR) ensures that these Abs attain pathogen-appropriate effector functions. Although the enzyme critical to both processes, activation-induced cytidine deaminase, has been identified, it remains unclear which cis-elements within the Ig loci are responsible for recruiting activation-induced cytidine deaminase and promoting its activity. Studies showed that Ig gene-transcription levels are positively correlated with the frequency of SHM and CSR, making the intronic, transcriptional enhancer Eμ a likely contributor to both processes. Tests of this hypothesis yielded mixed results arising, in part, from the difficulty in studying B cell function in mice devoid of Eμ. In Eμ's absence, V(H) gene assembly is dramatically impaired, arresting B cell development. The current study circumvented this problem by modifying the murine Igh locus through simultaneous insertion of a fully assembled V(H) gene and deletion of Eμ. The behavior of this allele was compared with that of a matched allele carrying the same V(H) gene but with Eμ intact. Although IgH transcription was as great or greater on the Eμ-deficient allele, CSR and SHM were consistently, but modestly, reduced relative to the allele in which Eμ remained intact. We conclude that Eμ contributes to, but is not essential for, these complex processes and that its contribution is not as a transcriptional enhancer but, rather, is at the level of recruitment and/or activation of the SHM/CSR machinery.

  7. Structural health monitoring of compression connectors for overhead transmission lines

    NASA Astrophysics Data System (ADS)

    Wang, Hong; Wang, Jy-An John; Swindeman, Joseph P.; Ren, Fei; Chan, John

    2017-04-01

    Two-stage aluminum conductor steel-reinforced (ACSR) compression connectors are extensively used in US overhead transmission lines. The connectors are made by crimping a steel sleeve onto a steel core and an aluminum sleeve over electrical conducting aluminum strands. The connectors are designed to operate at temperatures up to 125°C, but their performance is increasingly degrading because of overloading of lines. Currently, electric utilities conduct routine line inspections using thermal and electrical measurements, but these methods do not provide information about the structural integrity of connectors. In this work, structural health monitoring (SHM) of compression connectors was studied using electromechanical impedance (EMI) analysis. Lead zirconate titanate (PZT)-5A was identified as a smart material for SHM. A flexible high-temperature bonding layer was used to address challenges in PZT integration due to a significant difference in the coefficients of thermal expansion of PZT and the aluminum substrate. The steel joint on the steel core was investigated because it is responsible for the ultimate tensile strength of the connector. Tensile testing was used to induce structural damage to the joint, or steel core pullout, and thermal cycling introduced additional structural perturbations. EMI measurements were conducted between the tests. The root mean square deviation (RMSD) of EMI was identified as a damage index. The use of steel joints has been shown to enable SHM under simulated conditions. The EMI signature is sensitive to variations in structural conditions. RMSD can be correlated to the structural health of a connector and has potential for use in the SHM and structural integrity evaluation.

  8. Surface density mapping of natural tissue by a scanning haptic microscope (SHM).

    PubMed

    Moriwaki, Takeshi; Oie, Tomonori; Takamizawa, Keiichi; Murayama, Yoshinobu; Fukuda, Toru; Omata, Sadao; Nakayama, Yasuhide

    2013-02-01

    To expand the performance capacity of the scanning haptic microscope (SHM) beyond surface mapping microscopy of elastic modulus or topography, surface density mapping of a natural tissue was performed by applying a measurement theory of SHM, in which a frequency change occurs upon contact of the sample surface with the SHM sensor - a microtactile sensor (MTS) that vibrates at a pre-determined constant oscillation frequency. This change was mainly stiffness-dependent at a low oscillation frequency and density-dependent at a high oscillation frequency. Two paragon examples with extremely different densities but similar macroscopic elastic moduli in the range of natural soft tissues were selected: one was agar hydrogels and the other silicon organogels with extremely low (less than 25 mg/cm(3)) and high densities (ca. 1300 mg/cm(3)), respectively. Measurements were performed in saline solution near the second-order resonance frequency, which led to the elastic modulus, and near the third-order resonance frequency. There was little difference in the frequency changes between the two resonance frequencies in agar gels. In contrast, in silicone gels, a large frequency change by MTS contact was observed near the third-order resonance frequency, indicating that the frequency change near the third-order resonance frequency reflected changes in both density and elastic modulus. Therefore, a density image of the canine aortic wall was subsequently obtained by subtracting the image observed near the second-order resonance frequency from that near the third-order resonance frequency. The elastin-rich region had a higher density than the collagen-rich region.

  9. Wireless Smart Sensor Network System Using SmartBridge Sensor Nodes for Structural Health Monitoring of Existing Concrete Bridges

    NASA Astrophysics Data System (ADS)

    Gaviña, J. R.; Uy, F. A.; Carreon, J. D.

    2017-06-01

    There are over 8000 bridges in the Philippines today according to the Department of Public Works and Highways (DPWH). Currently, visual inspection is the most common practice in monitoring the structural integrity of bridges. However, visual inspections have proven to be insufficient in determining the actual health or condition of a bridge. Structural Health Monitoring (SHM) aims to give, in real-time, a diagnosis of the actual condition of the bridge. In this study, SmartBridge Sensor Nodes were installed on an existing concrete bridge with American Association of State Highway and Transportation Officials (AASHTO) Type IV Girders to gather vibration of the elements of the bridge. Also, standards on the effective installation of SmartBridge Sensor Nodes, such as location and orientation was determined. Acceleration readings from the sensor were then uploaded to a server, wherein they are monitored against certain thresholds, from which, the health of the bridge will be derived. Final output will be a portal or webpage wherein the information, health, and acceleration readings of the bridge will be available for viewing. With levels of access set for different types of users, the main users will have access to download data and reports. Data transmission and webpage access are available online, making the SHM system wireless.

  10. An autonomous structural health monitoring solution

    NASA Astrophysics Data System (ADS)

    Featherston, Carol A.; Holford, Karen M.; Pullin, Rhys; Lees, Jonathan; Eaton, Mark; Pearson, Matthew

    2013-05-01

    Combining advanced sensor technologies, with optimised data acquisition and diagnostic and prognostic capability, structural health monitoring (SHM) systems provide real-time assessment of the integrity of bridges, buildings, aircraft, wind turbines, oil pipelines and ships, leading to improved safety and reliability and reduced inspection and maintenance costs. The implementation of power harvesting, using energy scavenged from ambient sources such as thermal gradients and sources of vibration in conjunction with wireless transmission enables truly autonomous systems, reducing the need for batteries and associated maintenance in often inaccessible locations, alongside bulky and expensive wiring looms. The design and implementation of such a system however presents numerous challenges. A suitable energy source or multiple sources capable of meeting the power requirements of the system, over the entire monitoring period, in a location close to the sensor must be identified. Efficient power management techniques must be used to condition the power and deliver it, as required, to enable appropriate measurements to be taken. Energy storage may be necessary, to match a continuously changing supply and demand for a range of different monitoring states including sleep, record and transmit. An appropriate monitoring technique, capable of detecting, locating and characterising damage and delivering reliable information, whilst minimising power consumption, must be selected. Finally a wireless protocol capable of transmitting the levels of information generated at the rate needed in the required operating environment must be chosen. This paper considers solutions to some of these challenges, and in particular examines SHM in the context of the aircraft environment.

  11. Soil Moisture fusion across scales using a multiscale nonstationary Spatial Hierarchical Model

    NASA Astrophysics Data System (ADS)

    Kathuria, D.; Mohanty, B.; Katzfuss, M.

    2017-12-01

    Soil moisture (SM) datasets from remote sensing (RS) platforms (such as SMOS and SMAP) and reanalysis products from land surface models are typically available on a coarse spatial granularity of several square km. Ground based sensors, on the other hand, provide observations on a finer spatial scale (meter scale or less) but are sparsely available. SM is affected by high variability due to complex interactions between geologic, topographic, vegetation and atmospheric variables and these interactions change dynamically with footprint scales. Past literature has largely focused on the scale specific effect of these covariates on soil moisture. The present study proposes a robust Multiscale-Nonstationary Spatial Hierarchical Model (MN-SHM) which can assimilate SM from point to RS footprints. The spatial structure of SM across footprints is modeled by a class of scalable covariance functions whose nonstationary depends on atmospheric forcings (such as precipitation) and surface physical controls (such as topography, soil-texture and vegetation). The proposed model is applied to fuse point and airborne ( 1.5 km) SM data obtained during the SMAPVEX12 campaign in the Red River watershed in Southern Manitoba, Canada with SMOS ( 30km) data. It is observed that precipitation, soil-texture and vegetation are the dominant factors which affect the SM distribution across various footprint scales (750 m, 1.5 km, 3 km, 9 km,15 km and 30 km). We conclude that MN-SHM handles the change of support problems easily while retaining reasonable predictive accuracy across multiple spatial resolutions in the presence of surface heterogeneity. The MN-SHM can be considered as a complex non-stationary extension of traditional geostatistical prediction methods (such as Kriging) for fusing multi-platform multi-scale datasets.

  12. Pathophysiology of B-cell intrinsic immunoglobulin class switch recombination deficiencies.

    PubMed

    Durandy, Anne; Taubenheim, Nadine; Peron, Sophie; Fischer, Alain

    2007-01-01

    B-cell intrinsic immunoglobulin class switch recombination (Ig-CSR) deficiencies, previously termed hyper-IgM syndromes, are genetically determined conditions characterized by normal or elevated serum IgM levels and an absence or very low levels of IgG, IgA, and IgE. As a function of the molecular mechanism, the defective CSR is variably associated to a defect in the generation of somatic hypermutations (SHMs) in the Ig variable region. The study of Ig-CSR deficiencies contributed to a better delineation of the mechanisms underlying CSR and SHM, the major events of antigen-triggered antibody maturation. Four Ig-CSR deficiency phenotypes have been so far reported: the description of the activation-induced cytidine deaminase (AID) deficiency (Ig-CSR deficiency 1), caused by recessive mutations of AICDA gene, characterized by a defect in CSR and SHM, clearly established the role of AID in the induction of the Ig gene rearrangements underlying CSR and SHM. A CSR-specific function of AID has, however, been detected by the observation of a selective CSR defect caused by mutations affecting the C-terminus of AID. Ig-CSR deficiency 2 is the consequence of uracil-N-glycosylase (UNG) deficiency. Because UNG, a molecule of the base excision repair machinery, removes uracils from DNA and AID deaminates cytosines into uracils, that observation indicates that the AID-UNG pathway directly targets DNA of switch regions from the Ig heavy-chain locus to induce the CSR process. Ig-CSR deficiencies 3 and 4 are characterized by a selective CSR defect resulting from blocks at distinct steps of CSR. A further understanding of the CSR machinery is expected from their molecular definition.

  13. Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs.

    PubMed

    Girelli Zubani, Giulia; Zivojnovic, Marija; De Smet, Annie; Albagli-Curiel, Olivier; Huetz, François; Weill, Jean-Claude; Reynaud, Claude-Agnès; Storck, Sébastien

    2017-04-03

    During somatic hypermutation (SHM) of immunoglobulin genes, uracils introduced by activation-induced cytidine deaminase are processed by uracil-DNA glycosylase (UNG) and mismatch repair (MMR) pathways to generate mutations at G-C and A-T base pairs, respectively. Paradoxically, the MMR-nicking complex Pms2/Mlh1 is apparently dispensable for A-T mutagenesis. Thus, how detection of U:G mismatches is translated into the single-strand nick required for error-prone synthesis is an open question. One model proposed that UNG could cooperate with MMR by excising a second uracil in the vicinity of the U:G mismatch, but it failed to explain the low impact of UNG inactivation on A-T mutagenesis. In this study, we show that uracils generated in the G1 phase in B cells can generate equal proportions of A-T and G-C mutations, which suggests that UNG and MMR can operate within the same time frame during SHM. Furthermore, we show that Ung -/- Pms2 -/- mice display a 50% reduction in mutations at A-T base pairs and that most remaining mutations at A-T bases depend on two additional uracil glycosylases, thymine-DNA glycosylase and SMUG1. These results demonstrate that Pms2/Mlh1 and multiple uracil glycosylases act jointly, each one with a distinct strand bias, to enlarge the immunoglobulin gene mutation spectrum from G-C to A-T bases. © 2017 Girelli Zubani et al.

  14. Pms2 and uracil-DNA glycosylases act jointly in the mismatch repair pathway to generate Ig gene mutations at A-T base pairs

    PubMed Central

    De Smet, Annie; Albagli-Curiel, Olivier; Huetz, François; Weill, Jean-Claude

    2017-01-01

    During somatic hypermutation (SHM) of immunoglobulin genes, uracils introduced by activation-induced cytidine deaminase are processed by uracil-DNA glycosylase (UNG) and mismatch repair (MMR) pathways to generate mutations at G-C and A-T base pairs, respectively. Paradoxically, the MMR-nicking complex Pms2/Mlh1 is apparently dispensable for A-T mutagenesis. Thus, how detection of U:G mismatches is translated into the single-strand nick required for error-prone synthesis is an open question. One model proposed that UNG could cooperate with MMR by excising a second uracil in the vicinity of the U:G mismatch, but it failed to explain the low impact of UNG inactivation on A-T mutagenesis. In this study, we show that uracils generated in the G1 phase in B cells can generate equal proportions of A-T and G-C mutations, which suggests that UNG and MMR can operate within the same time frame during SHM. Furthermore, we show that Ung−/−Pms2−/− mice display a 50% reduction in mutations at A-T base pairs and that most remaining mutations at A-T bases depend on two additional uracil glycosylases, thymine-DNA glycosylase and SMUG1. These results demonstrate that Pms2/Mlh1 and multiple uracil glycosylases act jointly, each one with a distinct strand bias, to enlarge the immunoglobulin gene mutation spectrum from G-C to A-T bases. PMID:28283534

  15. Preliminary calibration plan for the Advanced Particles and Field Observatory (APAFO) magnetometer experiment

    NASA Technical Reports Server (NTRS)

    Voorhies, C. V.; Langel, R. A.; Slavin, J.; Lancaster, E. R.; Jones, S.

    1991-01-01

    Prelaunch and postlaunch calibration plans for the APAFO magnetometer experiment are presented. A study of tradeoffs between boom length and spacecraft field is described; the results are summarized. The prelaunch plan includes: calibration of the Vector Fluxgate Magnetometer (VFM), Star Sensors, and Scalar Helium Magnetometer (SHM); optical bench integration; and acquisition of basic spacecraft field data. Postlaunch calibration has two phases. In phase one, SHM data are used to calibrate the VFM, total vector magnetic field data are used to calibrate a physical model of the spacecraft field, and both calibrations are refined by iteration. In phase two, corrected vector data are transformed into geocentric coordinates, previously undetected spacecraft fields are isolated, and initial geomagnetic field models are computed. Provided the SHM is accurate to the required 1.0 nT and can be used to calibrate the VFM to the required 3.0- nT accuracy, the tradeoff study indicates that a 12 m boom and a spacecraft field model uncertainty of 5 percent together allow the 1.0 nT spacecraft field error requirement to be met.

  16. Immunoglobulin Gene Insertions and Deletions in the Affinity Maturation of HIV-1 Broadly Reactive Neutralizing Antibodies

    PubMed Central

    Kepler, Thomas B.; Liao, Hua-Xin; Alam, S. Munir; Bhaskarabhatla, Rekha; Zhang, Ruijun; Stewart, Shelley; Anasti, Kara; Kelsoe, Garnett; Parks, Robert; Lloyd, Krissey E.; Stolarchuk, Christina; Pritchett, Jamie; Solomon, Erika; Friberg, Emma; Morris, Lynn; Karim, Salim S. Abdool; Cohen, Myron S.; Walter, Emmanuel; Moody, M. Anthony; Wu, Xueling; Altae-Tran, Han R.; Georgiev, Ivelin S.; Kwong, Peter D.; Boyd, Scott D.; Fire, Andrew Z.; Mascola, John R.; Haynes, Barton F.

    2014-01-01

    Summary Induction of HIV-1 broad neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development but has remained challenging partially due to unusual traits of bnAbs, including high somatic hypermutation (SHM) frequencies and in-frame insertions and deletions (indels). Here we examined the propensity and functional requirement for indels within HIV-1 bnAbs. High-throughput sequencing of the immunoglobulin (Ig) VHDJH genes in HIV-1 infected and uninfected individuals revealed that the indel frequency was elevated among HIV-1-infected subjects, with no unique properties attributable to bnAb-producing individuals. This increased indel occurrence depended only on the frequency of SHM point-mutations. Indel-encoded regions were generally proximal to antigen binding sites. Additionally, reconstruction of a HIV-1 CD4-binding site bnAb clonal lineage revealed that a large compound VHDJH indel was required for bnAb activity. Thus, vaccine development should focus on designing regimens targeted at sustained activation of bnAb lineages to achieve the required SHM and indel events. PMID:25211073

  17. The Use of Indirect Estimates of Soil Moisture to Initialize Coupled Models and its Impact on Short-Term and Seasonal Simulations

    NASA Technical Reports Server (NTRS)

    Lapenta, William M.; Crosson, William; Dembek, Scott; Lakhtakia, Mercedes

    1998-01-01

    It is well known that soil moisture is a characteristic of the land surface that strongly affects the partitioning of outgoing radiation into sensible and latent heat which significantly impacts both weather and climate. Detailed land surface schemes are now being coupled to mesoscale atmospheric models in order to represent the effect of soil moisture upon atmospheric simulations. However, there is little direct soil moisture data available to initialize these models on regional to continental scales. As a result, a Soil Hydrology Model (SHM) is currently being used to generate an indirect estimate of the soil moisture conditions over the continental United States at a grid resolution of 36 Km on a daily basis since 8 May 1995. The SHM is forced by analyses of atmospheric observations including precipitation and contains detailed information on slope soil and landcover characteristics.The purpose of this paper is to evaluate the utility of initializing a detailed coupled model with the soil moisture data produced by SHM.

  18. Guided wave energy trapping to detect hidden multilayer delamination damage

    NASA Astrophysics Data System (ADS)

    Leckey, Cara A. C.; Seebo, Jeffrey P.

    2015-03-01

    Nondestructive Evaluation (NDE) and Structural Health Monitoring (SHM) simulation tools capable of modeling three-dimensional (3D) realistic energy-damage interactions are needed for aerospace composites. Current practice in NDE/SHM simulation for composites commonly involves over-simplification of the material parameters and/or a simplified two-dimensional (2D) approach. The unique damage types that occur in composite materials (delamination, microcracking, etc) develop as complex 3D geometry features. This paper discusses the application of 3D custom ultrasonic simulation tools to study wave interaction with multilayer delamination damage in carbon-fiber reinforced polymer (CFRP) composites. In particular, simulation based studies of ultrasonic guided wave energy trapping due to multilayer delamination damage were performed. The simulation results show changes in energy trapping at the composite surface as additional delaminations are added through the composite thickness. The results demonstrate a potential approach for identifying the presence of hidden multilayer delamination damage in applications where only single-sided access to a component is available. The paper also describes recent advancements in optimizing the custom ultrasonic simulation code for increases in computation speed.

  19. Integrity of immunoglobulin variable regions is supported by GANP during AID-induced somatic hypermutation in germinal center B cells

    PubMed Central

    Eid, Mohammed Mansour Abbas; Shimoda, Mayuko; Singh, Shailendra Kumar; Almofty, Sarah Ameen; Pham, Phuong; Goodman, Myron F.; Maeda, Kazuhiko; Sakaguchi, Nobuo

    2017-01-01

    Abstract Immunoglobulin affinity maturation depends on somatic hypermutation (SHM) in immunoglobulin variable (IgV) regions initiated by activation-induced cytidine deaminase (AID). AID induces transition mutations by C→U deamination on both strands, causing C:G→T:A. Error-prone repairs of U by base excision and mismatch repairs (MMRs) create transversion mutations at C/G and mutations at A/T sites. In Neuberger’s model, it remained to be clarified how transition/transversion repair is regulated. We investigate the role of AID-interacting GANP (germinal center-associated nuclear protein) in the IgV SHM profile. GANP enhances transition mutation of the non-transcribed strand G and reduces mutation at A, restricted to GYW of the AID hotspot motif. It reduces DNA polymerase η hotspot mutations associated with MMRs followed by uracil-DNA glycosylase. Mutation comparison between IgV complementary and framework regions (FWRs) by Bayesian statistical estimation demonstrates that GANP supports the preservation of IgV FWR genomic sequences. GANP works to maintain antibody structure by reducing drastic changes in the IgV FWR in affinity maturation. PMID:28541550

  20. Application of Fault Management Theory to the Quantitative Selection of a Launch Vehicle Abort Trigger Suite

    NASA Technical Reports Server (NTRS)

    Lo, Yunnhon; Johnson, Stephen B.; Breckenridge, Jonathan T.

    2014-01-01

    The theory of System Health Management (SHM) and of its operational subset Fault Management (FM) states that FM is implemented as a "meta" control loop, known as an FM Control Loop (FMCL). The FMCL detects that all or part of a system is now failed, or in the future will fail (that is, cannot be controlled within acceptable limits to achieve its objectives), and takes a control action (a response) to return the system to a controllable state. In terms of control theory, the effectiveness of each FMCL is estimated based on its ability to correctly estimate the system state, and on the speed of its response to the current or impending failure effects. This paper describes how this theory has been successfully applied on the National Aeronautics and Space Administration's (NASA) Space Launch System (SLS) Program to quantitatively estimate the effectiveness of proposed abort triggers so as to select the most effective suite to protect the astronauts from catastrophic failure of the SLS. The premise behind this process is to be able to quantitatively provide the value versus risk trade-off for any given abort trigger, allowing decision makers to make more informed decisions. All current and planned crewed launch vehicles have some form of vehicle health management system integrated with an emergency launch abort system to ensure crew safety. While the design can vary, the underlying principle is the same: detect imminent catastrophic vehicle failure, initiate launch abort, and extract the crew to safety. Abort triggers are the detection mechanisms that identify that a catastrophic launch vehicle failure is occurring or is imminent and cause the initiation of a notification to the crew vehicle that the escape system must be activated. While ensuring that the abort triggers provide this function, designers must also ensure that the abort triggers do not signal that a catastrophic failure is imminent when in fact the launch vehicle can successfully achieve orbit. That is, the abort triggers must have low false negative rates to be sure that real crew-threatening failures are detected, and also low false positive rates to ensure that the crew does not abort from non-crew-threatening launch vehicle behaviors. The analysis process described in this paper is a compilation of over six years of lessons learned and refinements from experiences developing abort triggers for NASA's Constellation Program (Ares I Project) and the SLS Program, as well as the simultaneous development of SHM/FM theory. The paper will describe the abort analysis concepts and process, developed in conjunction with SLS Safety and Mission Assurance (S&MA) to define a common set of mission phase, failure scenario, and Loss of Mission Environment (LOME) combinations upon which the SLS Loss of Mission (LOM) Probabilistic Risk Assessment (PRA) models are built. This abort analysis also requires strong coordination with the Multi-Purpose Crew Vehicle (MPCV) and SLS Structures and Environments (STE) to formulate a series of abortability tables that encapsulate explosion dynamics over the ascent mission phase. The design and assessment of abort conditions and triggers to estimate their Loss of Crew (LOC) Benefits also requires in-depth integration with other groups, including Avionics, Guidance, Navigation and Control(GN&C), the Crew Office, Mission Operations, and Ground Systems. The outputs of this analysis are a critical input to SLS S&MA's LOC PRA models. The process described here may well be the first full quantitative application of SHM/FM theory to the selection of a sensor suite for any aerospace system.

  1. The ACES mission: scientific objectives and present status

    NASA Astrophysics Data System (ADS)

    Cacciapuoti, L.; Dimarcq, N.; Salomon, C.

    2017-11-01

    "Atomic Clock Ensemble in Space" (ACES) is a mission in fundamental physics that will operate a new generation of atomic clocks in the microgravity environment of the International Space Station (ISS). The ACES clock signal will combine the medium term frequency stability of a space hydrogen maser (SHM) and the long term stability and accuracy of a frequency standard based on cold cesium atoms (PHARAO). Fractional frequency stability and accuracy of few parts in 1016 will be achieved. The on-board time base distributed on Earth via a microwave link (MWL) will be used to test fundamental laws of physics (Einstein's theories of Special and General Relativity, Standard Model Extension, string theories…) and to develop applications in time and frequency metrology, universal time scales, global positioning and navigation, geodesy and gravimetry. After a general overview on the mission concept and its scientific objectives, the present status of ACES instruments and sub-systems will be discussed.

  2. Finite element modeling to determine thermal residual strain distribution of bonded composite repairs for structural health monitoring design

    NASA Astrophysics Data System (ADS)

    Baker, Wayne; Jones, Rhys; Davis, Claire; Galea, Stephen C.

    2002-11-01

    The economic implication of fleet upgrades, particularly in Australia with military aircraft such as the F-111 and F/A-18, has led to an increasing reliance on composite repair technology to address fatigue and corrosion-affected aircraft components. The increasing use of such repairs has led to a research effort to develop various in-situ health monitoring systems that may be incorporated with a repair. This paper reports on the development of a theoretical methodology that uses finite element analysis (FEA) to model the strain profiles which optical sensors, on or within the patch, will be exposed to under various operational scenarios, including load and disbond. Numerical techniques are then used to predict the fibre Bragg grating (FBG) reflections which occur with these strain profiles. The quality of these reflection are a key consideration when designing FBG based structural health monitoring (SHM) systems. This information can be used to optimise the location of both surface mounted, and embedded sensors, and determine feasibility of SHM system design. Research was conducted into the thermal residual strain (TRS) within the patch. A finite element study revealed the presence of significant thermal residual strain gradients along the surface of the tapered region of the patch. As Bragg gratings are particularly sensitive to strain gradients, (producing a result similar to a chirped grating) the strain gradient on the composite at potential sensor locations both under load, and in the event of disbond was considered. A sufficiently high gradient leads to an altered Bragg reflection. These spurious reflections need to be considered, and theoretically obtained reflections can provide information to allow for load scenarios where the Bragg shift is not a smooth, well defined peak. It can also be shown that embedded fibres offer a higher average thermal residual strain reading, while being subject to a much lower strain gradient. This particularly favors the optical disbond detection system that is being developed. While certification concerns exist with embedding sensors in repairs, this study shows that embedded optical fibre sensors may provide for a health monitoring system with enhanced reliability and sensitivity.

  3. Do the Effects of a Relationship Education Program Vary for Different Types of Couples? Exploratory Subgroup Analysis in the Supporting Healthy Marriage Evaluation. OPRE Report 2014-22

    ERIC Educational Resources Information Center

    Gubits, Daniel; Lowenstein, Amy E.; Harris, Jorgen; Hsueh, JoAnn

    2014-01-01

    The Supporting Healthy Marriage (SHM) evaluation was launched in 2003 to test the effectiveness of a skills-based relationship education program designed to help low-and modest-income married couples strengthen their relationships and to support more stable and more nurturing home environments and more positive outcomes for parents and their…

  4. Emergence of long distance bird migrations: a new model integrating global climate changes

    NASA Astrophysics Data System (ADS)

    Louchart, Antoine

    2008-12-01

    During modern birds history, climatic and environmental conditions have evolved on wide scales. In a continuously changing world, landbirds annual migrations emerged and developed. However, models accounting for the origins of these avian migrations were formulated with static ecogeographic perspectives. Here I reviewed Cenozoic paleoclimatic and paleontological data relative to the palearctic paleotropical long distance (LD) migration system. This led to propose a new model for the origin of LD migrations, the ‘shifting home’ model (SHM). It is based on a dynamic perspective of climate evolution and may apply to the origins of most modern migrations. Non-migrant tropical African bird taxa were present at European latitudes during most of the Cenozoic. Their distribution limits shifted progressively toward modern tropical latitudes during periods of global cooling and increasing seasonality. In parallel, decreasing winter temperatures in the western Palearctic drove shifts of population winter ranges toward the equator. I propose that this induced the emergence of most short distance migrations, and in turn LD migrations. This model reconciliates ecologically tropical ancestry of most LD migrants with predominant winter range shifts, in accordance with requirements for heritable homing. In addition, it is more parsimonious than other non-exclusive models. Greater intrinsic plasticity of winter ranges implied by the SHM is supported by recently observed impacts of the present global warming on migrating birds. This may induce particular threats to some LD migrants. The ancestral, breeding homes of LD migrants were not ‘northern’ or ‘southern’ but shifted across high and middle latitudes while migrations emerged through winter range shifts themselves.

  5. Big data and high-performance analytics in structural health monitoring for bridge management

    NASA Astrophysics Data System (ADS)

    Alampalli, Sharada; Alampalli, Sandeep; Ettouney, Mohammed

    2016-04-01

    Structural Health Monitoring (SHM) can be a vital tool for effective bridge management. Combining large data sets from multiple sources to create a data-driven decision-making framework is crucial for the success of SHM. This paper presents a big data analytics framework that combines multiple data sets correlated with functional relatedness to convert data into actionable information that empowers risk-based decision-making. The integrated data environment incorporates near real-time streams of semi-structured data from remote sensors, historical visual inspection data, and observations from structural analysis models to monitor, assess, and manage risks associated with the aging bridge inventories. Accelerated processing of dataset is made possible by four technologies: cloud computing, relational database processing, support from NOSQL database, and in-memory analytics. The framework is being validated on a railroad corridor that can be subjected to multiple hazards. The framework enables to compute reliability indices for critical bridge components and individual bridge spans. In addition, framework includes a risk-based decision-making process that enumerate costs and consequences of poor bridge performance at span- and network-levels when rail networks are exposed to natural hazard events such as floods and earthquakes. Big data and high-performance analytics enable insights to assist bridge owners to address problems faster.

  6. A nonlinear cointegration approach with applications to structural health monitoring

    NASA Astrophysics Data System (ADS)

    Shi, H.; Worden, K.; Cross, E. J.

    2016-09-01

    One major obstacle to the implementation of structural health monitoring (SHM) is the effect of operational and environmental variabilities, which may corrupt the signal of structural degradation. Recently, an approach inspired from the community of econometrics, called cointegration, has been employed to eliminate the adverse influence from operational and environmental changes and still maintain sensitivity to structural damage. However, the linear nature of cointegration may limit its application when confronting nonlinear relations between system responses. This paper proposes a nonlinear cointegration method based on Gaussian process regression (GPR); the method is constructed under the Engle-Granger framework, and tests for unit root processes are conducted both before and after the GPR is applied. The proposed approach is examined with real engineering data from the monitoring of the Z24 Bridge.

  7. Advanced end-to-end fiber optic sensing systems for demanding environments

    NASA Astrophysics Data System (ADS)

    Black, Richard J.; Moslehi, Behzad

    2010-09-01

    Optical fibers are small-in-diameter, light-in-weight, electromagnetic-interference immune, electrically passive, chemically inert, flexible, embeddable into different materials, and distributed-sensing enabling, and can be temperature and radiation tolerant. With appropriate processing and/or packaging, they can be very robust and well suited to demanding environments. In this paper, we review a range of complete end-to-end fiber optic sensor systems that IFOS has developed comprising not only (1) packaged sensors and mechanisms for integration with demanding environments, but (2) ruggedized sensor interrogators, and (3) intelligent decision aid algorithms software systems. We examine the following examples: " Fiber Bragg Grating (FBG) optical sensors systems supporting arrays of environmentally conditioned multiplexed FBG point sensors on single or multiple optical fibers: In conjunction with advanced signal processing, decision aid algorithms and reasoners, FBG sensor based structural health monitoring (SHM) systems are expected to play an increasing role in extending the life and reducing costs of new generations of aerospace systems. Further, FBG based structural state sensing systems have the potential to considerably enhance the performance of dynamic structures interacting with their environment (including jet aircraft, unmanned aerial vehicles (UAVs), and medical or extravehicular space robots). " Raman based distributed temperature sensing systems: The complete length of optical fiber acts as a very long distributed sensor which may be placed down an oil well or wrapped around a cryogenic tank.

  8. Guaranteeing robustness of structural condition monitoring to environmental variability

    NASA Astrophysics Data System (ADS)

    Van Buren, Kendra; Reilly, Jack; Neal, Kyle; Edwards, Harry; Hemez, François

    2017-01-01

    Advances in sensor deployment and computational modeling have allowed significant strides to be recently made in the field of Structural Health Monitoring (SHM). One widely used SHM strategy is to perform a vibration analysis where a model of the structure's pristine (undamaged) condition is compared with vibration response data collected from the physical structure. Discrepancies between model predictions and monitoring data can be interpreted as structural damage. Unfortunately, multiple sources of uncertainty must also be considered in the analysis, including environmental variability, unknown model functional forms, and unknown values of model parameters. Not accounting for these sources of uncertainty can lead to false-positives or false-negatives in the structural condition assessment. To manage the uncertainty, we propose a robust SHM methodology that combines three technologies. A time series algorithm is trained using "baseline" data to predict the vibration response, compare predictions to actual measurements collected on a potentially damaged structure, and calculate a user-defined damage indicator. The second technology handles the uncertainty present in the problem. An analysis of robustness is performed to propagate this uncertainty through the time series algorithm and obtain the corresponding bounds of variation of the damage indicator. The uncertainty description and robustness analysis are both inspired by the theory of info-gap decision-making. Lastly, an appropriate "size" of the uncertainty space is determined through physical experiments performed in laboratory conditions. Our hypothesis is that examining how the uncertainty space changes throughout time might lead to superior diagnostics of structural damage as compared to only monitoring the damage indicator. This methodology is applied to a portal frame structure to assess if the strategy holds promise for robust SHM. (Publication approved for unlimited, public release on October-28-2015, LA-UR-15-28442, unclassified.)

  9. Development of a wireless displacement measurement system using acceleration responses.

    PubMed

    Park, Jong-Woong; Sim, Sung-Han; Jung, Hyung-Jo; Spencer, Billie F

    2013-07-01

    Displacement measurements are useful information for various engineering applications such as structural health monitoring (SHM), earthquake engineering and system identification. Most existing displacement measurement methods are costly, labor-intensive, and have difficulties particularly when applying to full-scale civil structures because the methods require stationary reference points. Indirect estimation methods converting acceleration to displacement can be a good alternative as acceleration transducers are generally cost-effective, easy to install, and have low noise. However, the application of acceleration-based methods to full-scale civil structures such as long span bridges is challenging due to the need to install cables to connect the sensors to a base station. This article proposes a low-cost wireless displacement measurement system using acceleration. Developed with smart sensors that are low-cost, wireless, and capable of on-board computation, the wireless displacement measurement system has significant potential to impact many applications that need displacement information at multiple locations of a structure. The system implements an FIR-filter type displacement estimation algorithm that can remove low frequency drifts typically caused by numerical integration of discrete acceleration signals. To verify the accuracy and feasibility of the proposed system, laboratory tests are carried out using a shaking table and on a three storey shear building model, experimentally confirming the effectiveness of the proposed system.

  10. Development of a Wireless Displacement Measurement System Using Acceleration Responses

    PubMed Central

    Park, Jong-Woong; Sim, Sung-Han; Jung, Hyung-Jo; Spencer, Billie F.

    2013-01-01

    Displacement measurements are useful information for various engineering applications such as structural health monitoring (SHM), earthquake engineering and system identification. Most existing displacement measurement methods are costly, labor-intensive, and have difficulties particularly when applying to full-scale civil structures because the methods require stationary reference points. Indirect estimation methods converting acceleration to displacement can be a good alternative as acceleration transducers are generally cost-effective, easy to install, and have low noise. However, the application of acceleration-based methods to full-scale civil structures such as long span bridges is challenging due to the need to install cables to connect the sensors to a base station. This article proposes a low-cost wireless displacement measurement system using acceleration. Developed with smart sensors that are low-cost, wireless, and capable of on-board computation, the wireless displacement measurement system has significant potential to impact many applications that need displacement information at multiple locations of a structure. The system implements an FIR-filter type displacement estimation algorithm that can remove low frequency drifts typically caused by numerical integration of discrete acceleration signals. To verify the accuracy and feasibility of the proposed system, laboratory tests are carried out using a shaking table and on a three storey shear building model, experimentally confirming the effectiveness of the proposed system. PMID:23881123

  11. Full-scale fatigue tests of CX-100 wind turbine blades. Part I: testing

    NASA Astrophysics Data System (ADS)

    Farinholt, Kevin M.; Taylor, Stuart G.; Park, Gyuhae; Ammerman, Curtt M.

    2012-04-01

    This paper overviews the test setup and experimental methods for structural health monitoring (SHM) of two 9-meter CX-100 wind turbine blades that underwent fatigue loading at the National Renewable Energy Laboratory's (NREL) National Wind Technology Center (NWTC). The first blade was a pristine blade, which was manufactured to standard specifications for the CX-100 design. The second blade was manufactured for the University of Massachusetts, Lowell with intentional simulated defects within the fabric layup. Each blade was instrumented with piezoelectric transducers, accelerometers, acoustic emission sensors, and foil strain gauges. The blades underwent harmonic excitation at their first natural frequency using the Universal Resonant Excitation (UREX) system at NREL. Blades were initially excited at 25% of their design load, and then with steadily increasing loads until each blade reached failure. Data from the sensors were collected between and during fatigue loading sessions. The data were measured over multi-scale frequency ranges using a variety of acquisition equipment, including off-the-shelf systems and specially designed hardware developed at Los Alamos National Laboratory (LANL). The hardware systems were evaluated for their aptness in data collection for effective application of SHM methods to the blades. The results of this assessment will inform the selection of acquisition hardware and sensor types to be deployed on a CX-100 flight test to be conducted in collaboration with Sandia National Laboratory at the U.S. Department of Agriculture's (USDA) Conservation and Production Research Laboratory (CPRL) in Bushland, Texas.

  12. Estimation of the outer-sphere contribution to the activation volume for electron exchange reactions using the mean spherical approximation

    NASA Astrophysics Data System (ADS)

    Takagi, Hideo D.; Swaddle, Thomas W.

    1996-01-01

    The outer-sphere contribution to the volume of activation of homogeneous electron exchange reactions is estimated for selected solvents on the basis of the mean spherical approximation (MSA), and the calculated values are compared with those estimated by the Strank-Hush-Marcus (SHM) theory and with activation volumes obtained experimentally for the electron exchange reaction between tris(hexafluoroacetylacetonato)ruthenium(III) and -(II) in acetone, acetonitrile, methanol and chloroform. The MSA treatment, which recognizes the molecular nature of the solvent, does not improve significantly upon the continuous-dielectric SHM theory, which represents the experimental data adequately for the more polar solvents.

  13. Tibial rotation kinematics subsequent to knee arthroplasty

    PubMed Central

    Collins, Duane J.; Khatib, Yasser H.; Parker, David A.; Jenkin, Deanne E.; Molnar, Robert B.

    2015-01-01

    Background The use of computer assisted joint replacement has facilitated precise intraoperative measurement of knee kinematics. The changes in “screw home mechanism” (SHM) resulting from Total Knee Arthroplasty (TKA) with different prostheses and constraints has not yet been accurately described. Methods A pilot study was first completed. Intraoperative kinematic data was collected two groups of 15 patients receiving different prostheses. Results On average, patients lost 5.3° of ER (SD = 6.1°). There was no significant difference between the prostheses or different prosthetic constraints. Conclusions There significant loss of SHM after TKA. Further research is required to understand its impact on patient function. PMID:25829754

  14. Structural health monitoring apparatus and methodology

    NASA Technical Reports Server (NTRS)

    Giurgiutiu, Victor (Inventor); Yu, Lingyu (Inventor); Bottai, Giola Santoni (Inventor)

    2011-01-01

    Disclosed is an apparatus and methodology for structural health monitoring (SHM) in which smart devices interrogate structural components to predict failure, expedite needed repairs, and thus increase the useful life of those components. Piezoelectric wafer active sensors (PWAS) are applied to or integrated with structural components and various data collected there from provide the ability to detect and locate cracking, corrosion, and disbanding through use of pitch-catch, pulse-echo, electro/mechanical impedance, and phased array technology. Stand alone hardware and an associated software program are provided that allow selection of multiple types of SHM investigations as well as multiple types of data analysis to perform a wholesome investigation of a structure.

  15. New applications of a model of electromechanical impedance for SHM

    NASA Astrophysics Data System (ADS)

    Pavelko, Vitalijs

    2014-03-01

    The paper focuses on the further development of the model of the electromechanical impedance (EMI) of the piezoceramics transducer (PZT) and its application for aircraft structural health monitoring (SHM). There was obtained an expression of the electromechanical impedance common to any dimension of models (1D, 2D, 3D), and directly independent from imposed constraints. Determination of the dynamic response of the system "host structure - PZT", which is crucial for the practical application supposes the use of modal analysis. This allows to get a general tool to determine EMI regardless of the specific features of a particular application. Earlier there was considered the technology of separate determination of the dynamic response for the PZT and the structural element". Here another version that involves the joint modal analysis of the entire system "host structure - PZT" is presented. As a result, the dynamic response is obtained in the form of modal decomposition of transducer mechanical strains. The use of models for the free and constrained transducer, analysis of the impact of the adhesive layer to the EMI is demonstrated. In all cases there was analyzed the influence of the dimension of the model (2D and 3D). The validity of the model is confirmed by experimental studies. Correlation between the fatigue crack length in a thin-walled Al plate and EMI of embedded PZT was simulated and compared with test result.

  16. A two-step FEM-SEM approach for wave propagation analysis in cable structures

    NASA Astrophysics Data System (ADS)

    Zhang, Songhan; Shen, Ruili; Wang, Tao; De Roeck, Guido; Lombaert, Geert

    2018-02-01

    Vibration-based methods are among the most widely studied in structural health monitoring (SHM). It is well known, however, that the low-order modes, characterizing the global dynamic behaviour of structures, are relatively insensitive to local damage. Such local damage may be easier to detect by methods based on wave propagation which involve local high frequency behaviour. The present work considers the numerical analysis of wave propagation in cables. A two-step approach is proposed which allows taking into account the cable sag and the distribution of the axial forces in the wave propagation analysis. In the first step, the static deformation and internal forces are obtained by the finite element method (FEM), taking into account geometric nonlinear effects. In the second step, the results from the static analysis are used to define the initial state of the dynamic analysis which is performed by means of the spectral element method (SEM). The use of the SEM in the second step of the analysis allows for a significant reduction in computational costs as compared to a FE analysis. This methodology is first verified by means of a full FE analysis for a single stretched cable. Next, simulations are made to study the effects of damage in a single stretched cable and a cable-supported truss. The results of the simulations show how damage significantly affects the high frequency response, confirming the potential of wave propagation based methods for SHM.

  17. Characterization and Design of Spiral Frequency Steerable Acoustic Transducers

    NASA Astrophysics Data System (ADS)

    Repale, Rohan

    Structural Health Monitoring (SHM) is an emerging research area devoted to improving the safety and maintainability of civil structures. Guided wave structural testing method is an effective approach used for SHM of plate-like structures using piezoelectric transducers. These transducers are attached to the surface of the structure and are capable of sensing its health by using surface waves. Transducers with beam steering i.e. electronic scanning capabilities can perform surface interrogation with higher precision and ease. A frequency steerable acoustic transducer (FSAT) is capable of beam steering and directional surface wave sensing to detect and localize damage in structures. The objective of this research is to further explore the possibilities of FSAT technology by designing and testing new FSAT designs. The beam steering capability of FSAT can be controlled by manipulating its design parameters. These design parameters therefore play a significant role in FSAT's performance. Studying the design parameters and documenting the performance improvements based on parameter variation is the primary goal of this research. Design and characterization of spiral FSAT was performed and results were simulated. Array FSAT documented results were validated. Modified designs were modeled based on design parameter variations. Characterization of these designs was done and their performance was recorded. Plate simulation results confirm direct relationship between design parameters and beam steering. A set of guidelines for future designs was also proposed. Two designs developed based on the set guidelines were sent to our collaborator Genziko Inc. for fabrication.

  18. Molecular mechanism of immunoglobulin V-region diversification regulated by transcription and RNA metabolism in antigen-driven B cells.

    PubMed

    Sakaguchi, N; Maeda, K; Kuwahara, K

    2011-06-01

    The immune system produces specific antibodies (Ab) against any antigens (Ag) of exogenous and endogenous origins with a diverse repertoire of V-region specificities. The primary V-region repertoire is created by the rearrangement of immunoglobulin (Ig) V-region, D- and J-segments with the insertion of N- and P-sequences during early B cell differentiation. Recent studies revealed that secondary diversification of the IgV-region generated in the peripheral lymphoid organs plays a critical role in the generation of effective Ab production for protection from various pathogens. Naïve B cells that react with Ags initiate proliferation and differentiation in the follicular region and create the germinal centres (GCs), where activation-induced cytidine deaminase (AID)-dependent IgV-region somatic hypermutation (SHM) and class-switch recombination generate high-affinity and class-switched mature Ag-specific B cells. Our studies have discovered a 210-kDa nuclear protein, named GC-associated nuclear protein (GANP) that is up-regulated in GC B cells during the T cell-dependent (TD) immune responses. By studying mice with mutant forms of the ganp gene, we demonstrated that GANP is essential for the generation of high-affinity B cells against TD-Ag by affecting SHM at the IgV-regions. GANP is associated with AID in the cytoplasm and the GANP/AID complex is recruited to the nucleus, specifically, the chromatin, and targeted selectively to the IgV-region gene in B cells. GANP augments the access of AID towards IgV-regions in B cells. Here, we review the role of GANP in acquired immunity through the detailed analysis of the molecular mechanism generating SHM specifically at IgV-regions in B cells. © 2011 The Authors. Scandinavian Journal of Immunology © 2011 Blackwell Publishing Ltd.

  19. Project Stakeholder Management in the Clinical Research Environment: How to Do it Right

    PubMed Central

    Pandi-Perumal, Seithikurippu R.; Akhter, Sohel; Zizi, Ferdinard; Jean-Louis, Girardin; Ramasubramanian, Chellamuthu; Edward Freeman, R.; Narasimhan, Meera

    2015-01-01

    This review introduces a conceptual framework for understanding stakeholder management (ShM) in the clinical and community-based research environment. In recent years, an evolution in practice has occurred in many applicants for public and non-governmental funding of public health research in hospital settings. Community health research projects are inherently complex, have sought to involve patients and other stakeholders in the center of the research process. Substantial evidence has now been provided that stakeholder involvement is essential for management effectiveness in clinical research. Feedback from stakeholders has critical value for research managers inasmuch as it alerts them to the social, environmental, and ethical implications of research activities. Additionally, those who are directly affected by program development and clinical research, the patients, their families, and others, almost universally have a strong motivation to be involved in the planning and execution of new program changes. The current overview introduces a conceptual framework for ShM in the clinical research environment and offers practical suggestions for fostering meaningful stakeholder engagement. The fifth edition of PMBOK® of the Project Management Institute, has served as basis for many of the suggested guidelines that are put forward in this article. PMID:26042053

  20. XRCC1 suppresses somatic hypermutation and promotes alternative nonhomologous end joining in Igh genes.

    PubMed

    Saribasak, Huseyin; Maul, Robert W; Cao, Zheng; McClure, Rhonda L; Yang, William; McNeill, Daniel R; Wilson, David M; Gearhart, Patricia J

    2011-10-24

    Activation-induced deaminase (AID) deaminates cytosine to uracil in immunoglobulin genes. Uracils in DNA can be recognized by uracil DNA glycosylase and abasic endonuclease to produce single-strand breaks. The breaks are repaired either faithfully by DNA base excision repair (BER) or mutagenically to produce somatic hypermutation (SHM) and class switch recombination (CSR). To unravel the interplay between repair and mutagenesis, we decreased the level of x-ray cross-complementing 1 (XRCC1), a scaffold protein involved in BER. Mice heterozygous for XRCC1 showed a significant increase in the frequencies of SHM in Igh variable regions in Peyer's patch cells, and of double-strand breaks in the switch regions during CSR. Although the frequency of CSR was normal in Xrcc1(+/-) splenic B cells, the length of microhomology at the switch junctions decreased, suggesting that XRCC1 also participates in alternative nonhomologous end joining. Furthermore, Xrcc1(+/-) B cells had reduced Igh/c-myc translocations during CSR, supporting a role for XRCC1 in microhomology-mediated joining. Our results imply that AID-induced single-strand breaks in Igh variable and switch regions become substrates simultaneously for BER and mutagenesis pathways.

  1. Integrity of immunoglobulin variable regions is supported by GANP during AID-induced somatic hypermutation in germinal center B cells.

    PubMed

    Eid, Mohammed Mansour Abbas; Shimoda, Mayuko; Singh, Shailendra Kumar; Almofty, Sarah Ameen; Pham, Phuong; Goodman, Myron F; Maeda, Kazuhiko; Sakaguchi, Nobuo

    2017-05-01

    Immunoglobulin affinity maturation depends on somatic hypermutation (SHM) in immunoglobulin variable (IgV) regions initiated by activation-induced cytidine deaminase (AID). AID induces transition mutations by C→U deamination on both strands, causing C:G→T:A. Error-prone repairs of U by base excision and mismatch repairs (MMRs) create transversion mutations at C/G and mutations at A/T sites. In Neuberger's model, it remained to be clarified how transition/transversion repair is regulated. We investigate the role of AID-interacting GANP (germinal center-associated nuclear protein) in the IgV SHM profile. GANP enhances transition mutation of the non-transcribed strand G and reduces mutation at A, restricted to GYW of the AID hotspot motif. It reduces DNA polymerase η hotspot mutations associated with MMRs followed by uracil-DNA glycosylase. Mutation comparison between IgV complementary and framework regions (FWRs) by Bayesian statistical estimation demonstrates that GANP supports the preservation of IgV FWR genomic sequences. GANP works to maintain antibody structure by reducing drastic changes in the IgV FWR in affinity maturation. © The Author 2017. Published by Oxford University Press on behalf of The Japanese Society for Immunology.

  2. Project Stakeholder Management in the Clinical Research Environment: How to Do it Right.

    PubMed

    Pandi-Perumal, Seithikurippu R; Akhter, Sohel; Zizi, Ferdinard; Jean-Louis, Girardin; Ramasubramanian, Chellamuthu; Edward Freeman, R; Narasimhan, Meera

    2015-01-01

    This review introduces a conceptual framework for understanding stakeholder management (ShM) in the clinical and community-based research environment. In recent years, an evolution in practice has occurred in many applicants for public and non-governmental funding of public health research in hospital settings. Community health research projects are inherently complex, have sought to involve patients and other stakeholders in the center of the research process. Substantial evidence has now been provided that stakeholder involvement is essential for management effectiveness in clinical research. Feedback from stakeholders has critical value for research managers inasmuch as it alerts them to the social, environmental, and ethical implications of research activities. Additionally, those who are directly affected by program development and clinical research, the patients, their families, and others, almost universally have a strong motivation to be involved in the planning and execution of new program changes. The current overview introduces a conceptual framework for ShM in the clinical research environment and offers practical suggestions for fostering meaningful stakeholder engagement. The fifth edition of PMBOK(®) of the Project Management Institute, has served as basis for many of the suggested guidelines that are put forward in this article.

  3. 3D Guided Wave Motion Analysis on Laminated Composites

    NASA Technical Reports Server (NTRS)

    Tian, Zhenhua; Leckey, Cara; Yu, Lingyu

    2013-01-01

    Ultrasonic guided waves have proved useful for structural health monitoring (SHM) and nondestructive evaluation (NDE) due to their ability to propagate long distances with less energy loss compared to bulk waves and due to their sensitivity to small defects in the structure. Analysis of actively transmitted ultrasonic signals has long been used to detect and assess damage. However, there remain many challenging tasks for guided wave based SHM due to the complexity involved with propagating guided waves, especially in the case of composite materials. The multimodal nature of the ultrasonic guided waves complicates the related damage analysis. This paper presents results from parallel 3D elastodynamic finite integration technique (EFIT) simulations used to acquire 3D wave motion in the subject laminated carbon fiber reinforced polymer composites. The acquired 3D wave motion is then analyzed by frequency-wavenumber analysis to study the wave propagation and interaction in the composite laminate. The frequency-wavenumber analysis enables the study of individual modes and visualization of mode conversion. Delamination damage has been incorporated into the EFIT model to generate "damaged" data. The potential for damage detection in laminated composites is discussed in the end.

  4. Optimal sensor placement for active guided wave interrogation of complex metallic components

    NASA Astrophysics Data System (ADS)

    Coelho, Clyde K.; Kim, Seung Bum; Chattopadhyay, Aditi

    2011-04-01

    With research in structural health monitoring (SHM) moving towards increasingly complex structures for damage interrogation, the placement of sensors is becoming a key issue in the performance of the damage detection methodologies. For ultrasonic wave based approaches, this is especially important because of the sensitivity of the travelling Lamb waves to material properties, geometry and boundary conditions that may obscure the presence of damage if they are not taken into account during sensor placement. The framework proposed in this paper defines a sensing region for a pair of piezoelectric transducers in a pitch-catch damage detection approach by taking into account the material attenuation and probability of false alarm. Using information about the region interrogated by a sensoractuator pair, a simulated annealing optimization framework was implemented in order to place sensors on complex metallic geometries such that a selected minimum damage type and size could be detected with an acceptable probability of false alarm anywhere on the structure. This approach was demonstrated on a lug joint to detect a crack and on a large Naval SHM test bed and resulted in a placement of sensors that was able to interrogate all parts of the structure using the minimum number of transducers.

  5. Investigation of piezoelectric impedance-based health monitoring of structure interface debonding

    NASA Astrophysics Data System (ADS)

    Xiao, Li; Chen, Guofeng; Chen, Xiaoming; Qu, Wenzhong

    2016-04-01

    Various damages might occur during the solid rocket motor (SRM) manufacturing/operational phase, and the debonding of propellant/insulator/composite case interfaces is one of damage types which determine the life of a motor. The detection of such interface debonding damage will be beneficial for developing techniques for reliable nondestructive evaluation (NDE) and structural health monitoring (SHM). Piezoelectric sensors are widely used for structural health monitoring technique. In particular, electromechanical impedance (EMI) techniques give simple and low-cost solutions for detecting damage in various structures. In this work, piezoelectric EMI structural health monitoring technique is applied to identify the debonding condition of propellant/insulator interface structure using finite element method and experimental investigation. A three-dimensional coupled field finite element model is developed using the software ANSYS and the harmonic analysis is conducted for high-frequency impedance analysis procedure. In the experimental study, the impedance signals were measured from PZT and MFC sensors outside attached to composite case monitoring the different debonding conditions between the propellant and insulator. Root mean square deviation (RMSD) based damage index is conducted to quantify the changes i n impedance for different de bonding conditions and frequency range. Simulation and experimental results confirmed that the EMI technique can be used effectively for detecting the debonding damage in SRM and is expected to be useful for future application of real SRM's SHM.

  6. Development of student performance assessment based on scientific approach for a basic physics practicum in simple harmonic motion materials

    NASA Astrophysics Data System (ADS)

    Serevina, V.; Muliyati, D.

    2018-05-01

    This research aims to develop students’ performance assessment instrument based on scientific approach is valid and reliable in assessing the performance of students on basic physics lab of Simple Harmonic Motion (SHM). This study uses the ADDIE consisting of stages: Analyze, Design, Development, Implementation, and Evaluation. The student performance assessment developed can be used to measure students’ skills in observing, asking, conducting experiments, associating and communicate experimental results that are the ‘5M’ stages in a scientific approach. Each grain of assessment in the instrument is validated by the instrument expert and the evaluation with the result of all points of assessment shall be eligible to be used with a 100% eligibility percentage. The instrument is then tested for the quality of construction, material, and language by panel (lecturer) with the result: 85% or very good instrument construction aspect, material aspect 87.5% or very good, and language aspect 83% or very good. For small group trial obtained instrument reliability level of 0.878 or is in the high category, where r-table is 0.707. For large group trial obtained instrument reliability level of 0.889 or is in the high category, where r-table is 0.320. Instruments declared valid and reliable for 5% significance level. Based on the result of this research, it can be concluded that the student performance appraisal instrument based on the developed scientific approach is declared valid and reliable to be used in assessing student skill in SHM experimental activity.

  7. Multiplexing Technology for Acoustic Emission Monitoring of Aerospace Vehicles

    NASA Technical Reports Server (NTRS)

    Prosser, William; Percy, Daniel

    2003-01-01

    The initiation and propagation of damage mechanisms such as cracks and delaminations generate acoustic waves, which propagate through a structure. These waves can be detected and analyzed to provide the location and severity of damage as part of a structural health monitoring (SHM) system. This methodology of damage detection is commonly known as acoustic emission (AE) monitoring, and is widely used on a variety of applications on civil structures. AE has been widely considered for SHM of aerospace vehicles. Numerous successful ground and flight test demonstrations have been performed, which show the viability of the technology for damage monitoring in aerospace structures. However, one significant current limitation for application of AE techniques on aerospace vehicles is the large size, mass, and power requirements for the necessary monitoring instrumentation. To address this issue, a prototype multiplexing approach has been developed and demonstrated in this study, which reduces the amount of AE monitoring instrumentation required. Typical time division multiplexing techniques that are commonly used to monitor strain, pressure and temperature sensors are not applicable to AE monitoring because of the asynchronous and widely varying rates of AE signal occurrence. Thus, an event based multiplexing technique was developed. In the initial prototype circuit, inputs from eight sensors in a linear array were multiplexed into two data acquisition channels. The multiplexer rapidly switches, in less than one microsecond, allowing the signals from two sensors to be acquired by a digitizer. The two acquired signals are from the sensors on either side of the trigger sensor. This enables the capture of the first arrival of the waves, which cannot be accomplished with the signal from the trigger sensor. The propagation delay to the slightly more distant neighboring sensors makes this possible. The arrival time from this first arrival provides a more accurate source location determination. The multiplexer also identifies which channels are acquired by encoding TTL logic pulses onto the latter portion of the signals. This prototype system was demonstrated using pencil lead break (Hsu-Neilsen) sources on an aluminum plate. It performed as designed providing rapid low noise trigger based switching with encoded channel identification. this multiplexing approach is not limited to linear arrays, but can be easily extended to monitor sensors in planar ot three dimensional arrays. A 32 channel multiplexing system is under development that will allow arbitrary sensor placement. Another benefit of this multiplexing system is the reduction in the expense of data acquisition hardware. In addition, the reduced weight and power requirements are of extreme importance for proposed AE systems on aerospace vehicles.

  8. A simplified design of the staggered herringbone micromixer for practical applications

    PubMed Central

    Du, Yan; Zhang, Zhiyi; Yim, ChaeHo; Lin, Min; Cao, Xudong

    2010-01-01

    We demonstrated a simple method for the device design of a staggered herringbone micromixer (SHM) using numerical simulation. By correlating the simulated concentrations with channel length, we obtained a series of concentration versus channel length profiles, and used mixing completion length Lm as the only parameter to evaluate the performance of device structure on mixing. Fluorescence quenching experiments were subsequently conducted to verify the optimized SHM structure for a specific application. Good agreement was found between the optimization and the experimental data. Since Lm is straightforward, easily defined and calculated parameter for characterization of mixing performance, this method for designing micromixers is simple and effective for practical applications. PMID:20697584

  9. A simplified design of the staggered herringbone micromixer for practical applications.

    PubMed

    Du, Yan; Zhang, Zhiyi; Yim, Chaeho; Lin, Min; Cao, Xudong

    2010-05-07

    We demonstrated a simple method for the device design of a staggered herringbone micromixer (SHM) using numerical simulation. By correlating the simulated concentrations with channel length, we obtained a series of concentration versus channel length profiles, and used mixing completion length L(m) as the only parameter to evaluate the performance of device structure on mixing. Fluorescence quenching experiments were subsequently conducted to verify the optimized SHM structure for a specific application. Good agreement was found between the optimization and the experimental data. Since L(m) is straightforward, easily defined and calculated parameter for characterization of mixing performance, this method for designing micromixers is simple and effective for practical applications.

  10. Towards improved NDE and SHM methodologies incorporating nonlinear structural features

    NASA Astrophysics Data System (ADS)

    Chillara, Vamshi Krishna

    Ultrasound is widely employed in Nondestructive Evaluation (NDE) and Structural Health Monitoring (SHM) applications to detect and characterize damage/defects in materials. In particular, ultrasonic guided waves are considered a foremost candidate for in-situ monitoring applications. Conventional ultrasonic techniques rely on changes/discontinuities in linear elastic material properties, namely the Young's modulus and shear modulus to detect damage. On the other hand, nonlinear ultrasonic techniques that rely on micro-scale nonlinear material/structural behavior are proven to be sensitive to damage induced microstructural changes that precede macro-scale damage and are hence capable of early damage detection. The goal of this thesis is to investigate the capabilities of nonlinear guided waves --- a fusion of nonlinear ultrasonic techniques with the guided wave methodologies for early damage detection. To that end, the thesis focuses on two important aspects of the problem: 1. Wavemechanics - deals with ultrasonic guided wave propagation in nonlinear waveguides; 2. Micromechanics - deals with correlating ultrasonic response with micro-scale nonlinear material behavior. For the development of efficient NDE and SHM methodologies that incorporate nonlinear structural features, a detailed understanding of the above aspects is indispensable. In this thesis, the wavemechanics aspect of the problem is dealt with from both theoretical and numerical standpoints. A generalized theoretical framework is developed to study higher harmonic guided waves in plates. This was employed to study second harmonic guided waves in pipes using a large-radius asymptotic approximation. Second harmonic guided waves in plates are studied from a numerical standpoint. Theoretical predictions are validated and some key aspects of higher harmonic generation in waveguides are outlined. Finally, second harmonic guided waves in plates with inhomogeneous and localized nonlinearities are studied and some important aspects of guided wave mode selection are addressed. The other part of the work focused on developing a micromechanics based understanding of ultrasonic higher harmonic generation. Three important aspects of micro-scale material behavior, namely tension-compression asymmetry, shearnormal coupling and deformation induced asymmetry are identified and their role in ultrasonic higher harmonic generation is discussed. Tension-compression asymmetry is identified to cause second (even) harmonic generation in materials. Then, shearnormal coupling is identified to cause generation of secondary waves of different polarity than the primary waves. In addition, deformation induced anisotropy due to the presence of residual stress/strain and its contribution to ultrasonic higher harmonic generation is qualitatively discussed. Also, the tension-compression asymmetry in the material is quantified using an energy based measure. The above measure is employed to develop a homogenization based approach amenable to multi-scale analysis to correlate microstructure with ultrasonic higher harmonic generation. Finally, experimental investigations concerning third harmonic SH wave generation in plates are carried out and the effect of load and temperature changes on nonlinear ultrasonic measurements are discussed in the context of SHM. It was found that while nonlinear ultrasound is sensitive to micro-scale damage, the relative nonlinearity parameter may not always be the best measure to quantify the nonlinearity as it is subject to spurious effects from changes in environmental factors such as loads and temperature.

  11. A novel embeddable spherical smart aggregate for structural health monitoring: part I. Fabrication and electrical characterization

    NASA Astrophysics Data System (ADS)

    Kong, Qingzhao; Fan, Shuli; Bai, Xiaolong; Mo, Y. L.; Song, Gangbing

    2017-09-01

    Recently developed piezoceramic-based transducers, known as smart aggregates (SAs), have shown their applicability and versatility in various applications of structural health monitoring (SHM). The lead zirconate titanate (PZT) patches embedded inside SAs have different modes that are more suitable for generating or receiving different types of stress waves (e.g. P and S waves, each of which has a unique role in SHM). However, due to the geometry of the 2D PZT patch, the embedded SA can only generate or receive the stress wave in a single direction and thus greatly limits its applications. This paper is the first of a series of two companion papers that introduces the authors’ latest work in developing a novel, embeddable spherical smart aggregate (SSA) for the health monitoring of concrete structures. In addition to the 1D guided wave produced by SA, the SSA embedded in concrete structures can generate or receive omni-directional stress waves that can significantly improve the detection aperture and provide additional functionalities in SHM. In the first paper (Part I), the detailed fabrication procedures with the help of 3D printing technology and electrical characterization of the proposed SSA is presented. The natural frequencies of the SSA were experimentally obtained and further compared with the numerical results. In addition, the influence of the components’ thickness (spherical piezoceramic shell and epoxy) and outer radius (spherical piezoceramic shell and protection concrete) on the natural frequencies of the SSA were analytically studied. The results will help elucidate the key parameters that determine the natural frequencies of the SSA. The natural frequencies of the SSA can thus be designed for suitability in the damage detection of concrete structures. In the second paper (Part II), further numerical and experimental verifications on the performance of the proposed SSA in concrete structures will be discussed.

  12. Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination

    PubMed Central

    HWANG, JOYCE K.; ALT, FREDERICK W.; YEAP, LENG-SIEW

    2015-01-01

    The primary antibody repertoire is generated by mechanisms involving the assembly of the exons that encode the antigen-binding variable regions of immunoglobulin heavy (IgH) and light (IgL) chains during the early development of B lymphocytes. After antigen-dependent activation, mature B lymphocytes can further alter their IgH and IgL variable region exons by the process of somatic hypermutation (SHM), which allows the selection of B cells in which SHMs resulted in the production of antibodies with increased antigen affinity. In addition, during antigen-dependent activation, B cells can also change the constant region of their IgH chain through a DNA double-strand-break (DSB) dependent process referred to as IgH class switch recombination (CSR), which generates B cell progeny that produce antibodies with different IgH constant region effector functions that are best suited for a elimination of a particular pathogen or in a particular setting. Both the mutations that underlie SHM and the DSBs that underlie CSR are initiated in target genes by activation-induced cytidine deaminase (AID). This review describes in depth the processes of SHM and CSR with a focus on mechanisms that direct AID cytidine deamination in activated B cells and mechanisms that promote the differential outcomes of such cytidine deamination. PMID:26104555

  13. Transcription factor YY1 can control AID-mediated mutagenesis in mice.

    PubMed

    Zaprazna, Kristina; Basu, Arindam; Tom, Nikola; Jha, Vibha; Hodawadekar, Suchita; Radova, Lenka; Malcikova, Jitka; Tichy, Boris; Pospisilova, Sarka; Atchison, Michael L

    2018-02-01

    Activation-induced cytidine deminase (AID) is crucial for controlling the immunoglobulin (Ig) diversification processes of somatic hypermutation (SHM) and class switch recombination (CSR). AID initiates these processes by deamination of cytosine, ultimately resulting in mutations or double strand DNA breaks needed for SHM and CSR. Levels of AID control mutation rates, and off-target non-Ig gene mutations can contribute to lymphomagenesis. Therefore, factors that control AID levels in the nucleus can regulate SHM and CSR, and may contribute to disease. We previously showed that transcription factor YY1 can regulate the level of AID in the nucleus and Ig CSR. Therefore, we hypothesized that conditional knock-out of YY1 would lead to reduction in AID localization at the Ig locus, and reduced AID-mediated mutations. Using mice that overexpress AID (IgκAID yy1 f/f ) or that express normal AID levels (yy1 f/f ), we found that conditional knock-out of YY1 results in reduced AID nuclear levels, reduced localization of AID to the Sμ switch region, and reduced AID-mediated mutations. We find that the mechanism of YY1 control of AID nuclear accumulation is likely due to YY1-AID physical interaction which blocks AID ubiquitination. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Epigenetics of Peripheral B-Cell Differentiation and the Antibody Response

    PubMed Central

    Zan, Hong; Casali, Paolo

    2015-01-01

    Epigenetic modifications, such as histone post-translational modifications, DNA methylation, and alteration of gene expression by non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are heritable changes that are independent from the genomic DNA sequence. These regulate gene activities and, therefore, cellular functions. Epigenetic modifications act in concert with transcription factors and play critical roles in B cell development and differentiation, thereby modulating antibody responses to foreign- and self-antigens. Upon antigen encounter by mature B cells in the periphery, alterations of these lymphocytes epigenetic landscape are induced by the same stimuli that drive the antibody response. Such alterations instruct B cells to undergo immunoglobulin (Ig) class switch DNA recombination (CSR) and somatic hypermutation (SHM), as well as differentiation to memory B cells or long-lived plasma cells for the immune memory. Inducible histone modifications, together with DNA methylation and miRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase, which is essential for CSR and SHM, and factors central to plasma cell differentiation, such as B lymphocyte-induced maturation protein-1. These inducible B cell-intrinsic epigenetic marks guide the maturation of antibody responses. Combinatorial histone modifications also function as histone codes to target CSR and, possibly, SHM machinery to the Ig loci by recruiting specific adaptors that can stabilize CSR/SHM factors. In addition, lncRNAs, such as recently reported lncRNA-CSR and an lncRNA generated through transcription of the S region that form G-quadruplex structures, are also important for CSR targeting. Epigenetic dysregulation in B cells, including the aberrant expression of non-coding RNAs and alterations of histone modifications and DNA methylation, can result in aberrant antibody responses to foreign antigens, such as those on microbial pathogens, and generation of pathogenic autoantibodies, IgE in allergic reactions, as well as B cell neoplasia. Epigenetic marks would be attractive targets for new therapeutics for autoimmune and allergic diseases, and B cell malignancies. PMID:26697022

  15. Noninfectious complications in patients with pediatric-onset common variable immunodeficiency correlated with defects in somatic hypermutation but not in class-switch recombination.

    PubMed

    Almejún, María Belén; Campos, Bárbara Carolina; Patiño, Virginia; Galicchio, Miguel; Zelazko, Marta; Oleastro, Matías; Oppezzo, Pablo; Danielian, Silvia

    2017-03-01

    Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by impaired immunoglobulin production and usually presents with a normal quantity of peripheral B cells. Most attempts aiming to classify these patients have mainly been focused on T- or B-cell phenotypes and their ability to produce protective antibodies, but it is still a major challenge to find a suitable classification that includes the clinical and immunologic heterogeneity of these patients. In this study we evaluated the late stages of B-cell differentiation in a heterogeneous population of patients with pediatric-onset CVID to clinically correlate and assess their ability to perform somatic hypermutation (SHM), class-switch recombination (CSR), or both. We performed a previously reported assay, the restriction enzyme hotspot mutation assay (IgκREHMA), to evaluate in vivo SHM status. We amplified switch regions from genomic DNA to investigate the quality of the double-strand break repairs in the class-switch recombination process in vivo. We also tested the ability to generate immunoglobulin germline and circle transcripts and to upregulate the activation-induced cytidine deaminase gene through in vitro T-dependent and T-independent stimuli. Our results showed that patients could be classified into 2 groups according to their degree of SHM alteration. This stratification showed a significant association between patients of group A, severe alteration, and the presence of noninfectious complications. Additionally, 60% of patients presented with increased microhomology use at switched regions. In vitro activation revealed that patients with CVID behaved heterogeneously in terms of responsiveness to T-dependent stimuli. The correlation between noninfectious complications and SHM could be an important tool for physicians to further characterize patients with CVID. This categorization would help to improve elucidation of the complex mechanisms involved in B-cell differentiation pathways. Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  16. Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation.

    PubMed

    Sheng, Zizhang; Schramm, Chaim A; Kong, Rui; Mullikin, James C; Mascola, John R; Kwong, Peter D; Shapiro, Lawrence

    2017-01-01

    Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous studies have shown that the propensity to mutate is modulated by the context of surrounding nucleotides and that SHM machinery generates biased substitutions. To investigate the intrinsic mutation frequency and substitution bias of SHMs at the amino acid level, we analyzed functional human antibody repertoires and developed mGSSP (method for gene-specific substitution profile), a method to construct amino acid substitution profiles from next-generation sequencing-determined B cell transcripts. We demonstrated that these gene-specific substitution profiles (GSSPs) are unique to each V gene and highly consistent between donors. We also showed that the GSSPs constructed from functional antibody repertoires are highly similar to those constructed from antibody sequences amplified from non-productively rearranged passenger alleles, which do not undergo functional selection. This suggests the types and frequencies, or mutational space, of a majority of amino acid changes sampled by the SHM machinery to be well captured by GSSPs. We further observed the rates of mutational exchange between some amino acids to be both asymmetric and context dependent and to correlate weakly with their biochemical properties. GSSPs provide an improved, position-dependent alternative to standard substitution matrices, and can be utilized to developing software for accurately modeling the SHM process. GSSPs can also be used for predicting the amino acid mutational space available for antigen-driven selection and for understanding factors modulating the maturation pathways of antibody lineages in a gene-specific context. The mGSSP method can be used to build, compare, and plot GSSPs; we report the GSSPs constructed for 69 common human V genes (DOI: 10.6084/m9.figshare.3511083) and provide high-resolution logo plots for each (DOI: 10.6084/m9.figshare.3511085).

  17. A Bayesian Approach for Sensor Optimisation in Impact Identification

    PubMed Central

    Mallardo, Vincenzo; Sharif Khodaei, Zahra; Aliabadi, Ferri M. H.

    2016-01-01

    This paper presents a Bayesian approach for optimizing the position of sensors aimed at impact identification in composite structures under operational conditions. The uncertainty in the sensor data has been represented by statistical distributions of the recorded signals. An optimisation strategy based on the genetic algorithm is proposed to find the best sensor combination aimed at locating impacts on composite structures. A Bayesian-based objective function is adopted in the optimisation procedure as an indicator of the performance of meta-models developed for different sensor combinations to locate various impact events. To represent a real structure under operational load and to increase the reliability of the Structural Health Monitoring (SHM) system, the probability of malfunctioning sensors is included in the optimisation. The reliability and the robustness of the procedure is tested with experimental and numerical examples. Finally, the proposed optimisation algorithm is applied to a composite stiffened panel for both the uniform and non-uniform probability of impact occurrence. PMID:28774064

  18. Prime-boost immunization by both DNA vaccine and oncolytic adenovirus expressing GM-CSF and shRNA of TGF-β2 induces anti-tumor immune activation.

    PubMed

    Kim, So Young; Kang, Dongxu; Choi, Hye Jin; Joo, Yeonsoo; Kim, Joo-Hang; Song, Jae J

    2017-02-28

    A successful DNA vaccine for the treatment of tumors should break established immune tolerance to tumor antigen. However, due to the relatively low immunogenicity of DNA vaccines, compared to other kinds of vaccines using live virus or protein, a recombinant viral vector was used to enhance humoral and cellular immunity. In the current study, we sought to develop a novel anti-cancer agent as a complex of DNA and oncolytic adenovirus for the treatment of malignant melanoma in the C57BL/6 mouse model. MART1, a human melanoma-specific tumor antigen, was used to induce an increased immune reaction, since a MART1-protective response is required to overcome immune tolerance to the melanoma antigen MelanA. Because GM-CSF is a potent inducer of anti-tumor immunity and TGF-β2 is involved in tumor survival and host immune suppression, mouse GM-CSF (mGM-CSF) and shRNA of mouse TGF-β2 (shmTGF-β2) genes were delivered together with MART1 via oncolytic adenovirus. MART1 plasmid was also used for antigen-priming. To compare the anti-tumor effect of oncolytic adenovirus expressing both mGM-CSF and shmTGF-β2 (AdGshT) with that of oncolytic adenovirus expressing mGM-CSF only (AdG), each virus was intratumorally injected into melanoma-bearing C57BL/6 mice. As a result, mice that received AdGshT showed delayed tumor growth than those that received AdG. Heterologous prime-boost immunization was combined with oncolytic AdGshT and MART1 expression to result in further delayed tumor growth. This regression is likely due to the following 4 combinations: MART1-derived mouse melanoma antigen-specific immune reaction, immune stimulation by mGM-CSF/shmTGF-β2, tumor growth inhibition by shmTGF-β2, and tumor cell-specific lysis via an oncolytic adenovirus. Immune activation was mainly induced by mature tumor-infiltrating dendritic cell (TIDC) and lowered regulatory T cells in tumor-infiltrating lymphocytes (TIL). Taken together, these findings demonstrate that human MART1 induces a mouse melanoma antigen-specific immune reaction. In addition, the results also indicate that combination therapy of MART1 plasmid, together with an oncolytic adenovirus expressing MART1, mGM-CSF, and shmTGF-β2, is a promising candidate for the treatment of malignant melanoma.

  19. Prime-boost immunization by both DNA vaccine and oncolytic adenovirus expressing GM-CSF and shRNA of TGF-β2 induces anti-tumor immune activation

    PubMed Central

    Choi, Hye Jin; Joo, Yeonsoo; Kim, Joo-Hang; Song, Jae J.

    2017-01-01

    A successful DNA vaccine for the treatment of tumors should break established immune tolerance to tumor antigen. However, due to the relatively low immunogenicity of DNA vaccines, compared to other kinds of vaccines using live virus or protein, a recombinant viral vector was used to enhance humoral and cellular immunity. In the current study, we sought to develop a novel anti-cancer agent as a complex of DNA and oncolytic adenovirus for the treatment of malignant melanoma in the C57BL/6 mouse model. MART1, a human melanoma-specific tumor antigen, was used to induce an increased immune reaction, since a MART1-protective response is required to overcome immune tolerance to the melanoma antigen MelanA. Because GM-CSF is a potent inducer of anti-tumor immunity and TGF-β2 is involved in tumor survival and host immune suppression, mouse GM-CSF (mGM-CSF) and shRNA of mouse TGF-β2 (shmTGF-β2) genes were delivered together with MART1 via oncolytic adenovirus. MART1 plasmid was also used for antigen-priming. To compare the anti-tumor effect of oncolytic adenovirus expressing both mGM-CSF and shmTGF-β2 (AdGshT) with that of oncolytic adenovirus expressing mGM-CSF only (AdG), each virus was intratumorally injected into melanoma-bearing C57BL/6 mice. As a result, mice that received AdGshT showed delayed tumor growth than those that received AdG. Heterologous prime-boost immunization was combined with oncolytic AdGshT and MART1 expression to result in further delayed tumor growth. This regression is likely due to the following 4 combinations: MART1-derived mouse melanoma antigen-specific immune reaction, immune stimulation by mGM-CSF/shmTGF-β2, tumor growth inhibition by shmTGF-β2, and tumor cell-specific lysis via an oncolytic adenovirus. Immune activation was mainly induced by mature tumor-infiltrating dendritic cell (TIDC) and lowered regulatory T cells in tumor-infiltrating lymphocytes (TIL). Taken together, these findings demonstrate that human MART1 induces a mouse melanoma antigen-specific immune reaction. In addition, the results also indicate that combination therapy of MART1 plasmid, together with an oncolytic adenovirus expressing MART1, mGM-CSF, and shmTGF-β2, is a promising candidate for the treatment of malignant melanoma. PMID:28178658

  20. A self-diagnostic adhesive for monitoring bonded joints in aerospace structures

    NASA Astrophysics Data System (ADS)

    Zhuang, Yitao; Li, Yu-hung; Kopsaftopoulos, Fotis; Chang, Fu-Kuo

    2016-04-01

    Bondline integrity is still one of the most critical concerns in the design of aircraft structures up to date. Due to the lack of confidence on the integrity of the bondline both during fabrication and service, the industry standards and regulations still require assembling the composite using conventional fasteners. Furthermore, current state-of-the-art non-destructive evaluation (NDE) and structural health monitoring (SHM) techniques are incapable of offering mature solutions on the issue of bondline integrity monitoring. Therefore, the objective of this work is the development of an intelligent adhesive film with integrated micro-sensors for monitoring the integrity of the bondline interface. The proposed method makes use of an electromechanical-impedance (EMI) based method, which is a rapidly evolving approach within the SHM family. Furthermore, an innovative screen-printing technique to fabricate piezoelectric ceramic sensors with minimal thickness has been developed at Stanford. The approach presented in this study is based on the use of (i) micro screen-printed piezoelectric sensors integrated into adhesive leaving a minimal footprint on the material, (ii) numerical and analytical modeling of the EMI spectrum of the adhesive bondline, (iii) novel diagnostic algorithms for monitoring the bondline integrity based on advanced signal processing techniques, and (iv) the experimental assessment via prototype adhesively bonded structures in static (varying loads) and dynamic (fatigue) environments. The proposed method will provide a huge confidence on the use of bonded joints for aerospace structures and lead to a paradigm change in their design by enabling enormous weight savings while maximizing the economic and performance efficiency.

  1. Damage evaluation and analysis of composite pressure vessels using fiber Bragg gratings to determine structural health

    NASA Astrophysics Data System (ADS)

    Ortyl, Nicholas E.

    2005-11-01

    The application of MEMS and nanotechnology (MNT) to the field of structural health monitoring (SHM) is a fairly recent development. The recent change in this focus for MNT has been driven by the need to expand the applications for much of the technologies that were developed in the late 1990s. In addition, many companies desire to expand beyond their target high volume market segments of automotive, wireless communications, and computer peripherals, since these market segments were not as lucrative as first predicted. Most of the aerospace structural health monitoring developmental activity has been sponsored by agencies of the U.S. Government, which serves to pace the examination of these newer technologies to some degree. With that said, efforts are underway by companies such as Acellent Technologies and Blue Road Research to explore various MNT structural health monitoring approaches. The MNT under test include embedded piezoelectric sensors, MEMS accelerometers, time domain region sensors, and topical and embedded single and multi-axis fiber optic Bragg grating sensors. The promise of MNT for the SHM market segment is very enticing. The many wireless communication developments and miniaturization developments of the past five years is very attractive to the SHM community, especially those that are able to reduce the cost and complexity of integration. The main challenge for the community is one of selective integration. That is, certain pieces may be appropriate for SHM systems and certain pieces may not be. The better companies will chose wisely and put forth an approach that can be seamlessly integrated into the larger structure. For over a decade, Blue Road Research has been developing technologies aimed at structural health monitoring of both composite and non-composite parts, through the use of single and multiaxis fiber optic Bragg grating sensors. These sensors are 80 to 120 microns in diameter making them smaller than the diameter of a human hair. Multiaxis fiber optic sensors are able to measure pressure, temperature, axial and transverse strain, chemical properties, corrosion, as well as transverse strain gradients. This technology is easily embedded in between the various layers of the composite structure, during manufacture, without compromising the structural integrity, in order to verify manufacturing parameters during the cure cycle and well as monitor the on-going condition of the composite structure throughout its life time. This paper reviews some of the technical work that has been accomplished during the past two years; specifically the embedding of fiber optic sensors into various composite structures in order to be able to conduct in situ non-destructive evaluation of the curing process and the service life of the component. The fiber optic technology has been developed to the point that it is at a TRL of 6.

  2. On-Line Multi-Damage Scanning Spatial-Wavenumber Filter Based Imaging Method for Aircraft Composite Structure.

    PubMed

    Ren, Yuanqiang; Qiu, Lei; Yuan, Shenfang; Bao, Qiao

    2017-05-11

    Structural health monitoring (SHM) of aircraft composite structure is helpful to increase reliability and reduce maintenance costs. Due to the great effectiveness in distinguishing particular guided wave modes and identifying the propagation direction, the spatial-wavenumber filter technique has emerged as an interesting SHM topic. In this paper, a new scanning spatial-wavenumber filter (SSWF) based imaging method for multiple damages is proposed to conduct on-line monitoring of aircraft composite structures. Firstly, an on-line multi-damage SSWF is established, including the fundamental principle of SSWF for multiple damages based on a linear piezoelectric (PZT) sensor array, and a corresponding wavenumber-time imaging mechanism by using the multi-damage scattering signal. Secondly, through combining the on-line multi-damage SSWF and a PZT 2D cross-shaped array, an image-mapping method is proposed to conduct wavenumber synthesis and convert the two wavenumber-time images obtained by the PZT 2D cross-shaped array to an angle-distance image, from which the multiple damages can be directly recognized and located. In the experimental validation, both simulated multi-damage and real multi-damage introduced by repeated impacts are performed on a composite plate structure. The maximum localization error is less than 2 cm, which shows good performance of the multi-damage imaging method. Compared with the existing spatial-wavenumber filter based damage evaluation methods, the proposed method requires no more than the multi-damage scattering signal and can be performed without depending on any wavenumber modeling or measuring. Besides, this method locates multiple damages by imaging instead of the geometric method, which helps to improve the signal-to-noise ratio. Thus, it can be easily applied to on-line multi-damage monitoring of aircraft composite structures.

  3. The effect of temperature and moisture on electrical resistance, strain sensitivity and crack sensitivity of steel fiber reinforced smart cement composite

    NASA Astrophysics Data System (ADS)

    Teomete, Egemen

    2016-07-01

    Earthquakes, material degradations and other environmental factors necessitate structural health monitoring (SHM). Metal foil strain gages used for SHM have low durability and low sensitivity. These factors motivated researchers to work on cement based strain sensors. In this study, the effects of temperature and moisture on electrical resistance, compressive and tensile strain gage factors (strain sensitivity) and crack sensitivity were determined for steel fiber reinforced cement based composite. A rapid increase of electrical resistance at 200 °C was observed due to damage occurring between cement paste, aggregates and steel fibers. The moisture—electrical resistance relationship was investigated. The specimens taken out of the cure were saturated with water and had a moisture content of 9.49%. The minimum electrical resistance was obtained at 9% moisture at which fiber-fiber and fiber-matrix contact was maximum and the water in micro voids was acting as an electrolyte, conducting electrons. The variation of compressive and tensile strain gage factors (strain sensitivities) and crack sensitivity were investigated by conducting compression, split tensile and notched bending tests with different moisture contents. The highest gage factor for the compression test was obtained at optimal moisture content, at which electrical resistance was minimum. The tensile strain gage factor for split tensile test and crack sensitivity increased by decreasing moisture content. The mechanisms between moisture content, electrical resistance, gage factors and crack sensitivity were elucidated. The relations of moisture content with electrical resistance, gage factors and crack sensitivities have been presented for the first time in this study for steel fiber reinforced cement based composites. The results are important for the development of self sensing cement based smart materials.

  4. On-Line Multi-Damage Scanning Spatial-Wavenumber Filter Based Imaging Method for Aircraft Composite Structure

    PubMed Central

    Ren, Yuanqiang; Qiu, Lei; Yuan, Shenfang; Bao, Qiao

    2017-01-01

    Structural health monitoring (SHM) of aircraft composite structure is helpful to increase reliability and reduce maintenance costs. Due to the great effectiveness in distinguishing particular guided wave modes and identifying the propagation direction, the spatial-wavenumber filter technique has emerged as an interesting SHM topic. In this paper, a new scanning spatial-wavenumber filter (SSWF) based imaging method for multiple damages is proposed to conduct on-line monitoring of aircraft composite structures. Firstly, an on-line multi-damage SSWF is established, including the fundamental principle of SSWF for multiple damages based on a linear piezoelectric (PZT) sensor array, and a corresponding wavenumber-time imaging mechanism by using the multi-damage scattering signal. Secondly, through combining the on-line multi-damage SSWF and a PZT 2D cross-shaped array, an image-mapping method is proposed to conduct wavenumber synthesis and convert the two wavenumber-time images obtained by the PZT 2D cross-shaped array to an angle-distance image, from which the multiple damages can be directly recognized and located. In the experimental validation, both simulated multi-damage and real multi-damage introduced by repeated impacts are performed on a composite plate structure. The maximum localization error is less than 2 cm, which shows good performance of the multi-damage imaging method. Compared with the existing spatial-wavenumber filter based damage evaluation methods, the proposed method requires no more than the multi-damage scattering signal and can be performed without depending on any wavenumber modeling or measuring. Besides, this method locates multiple damages by imaging instead of the geometric method, which helps to improve the signal-to-noise ratio. Thus, it can be easily applied to on-line multi-damage monitoring of aircraft composite structures. PMID:28772879

  5. A triaxial accelerometer monkey algorithm for optimal sensor placement in structural health monitoring

    NASA Astrophysics Data System (ADS)

    Jia, Jingqing; Feng, Shuo; Liu, Wei

    2015-06-01

    Optimal sensor placement (OSP) technique is a vital part of the field of structural health monitoring (SHM). Triaxial accelerometers have been widely used in the SHM of large-scale structures in recent years. Triaxial accelerometers must be placed in such a way that all of the important dynamic information is obtained. At the same time, the sensor configuration must be optimal, so that the test resources are conserved. The recommended practice is to select proper degrees of freedom (DOF) based upon several criteria and the triaxial accelerometers are placed at the nodes corresponding to these DOFs. This results in non-optimal placement of many accelerometers. A ‘triaxial accelerometer monkey algorithm’ (TAMA) is presented in this paper to solve OSP problems of triaxial accelerometers. The EFI3 measurement theory is modified and involved in the objective function to make it more adaptable in the OSP technique of triaxial accelerometers. A method of calculating the threshold value based on probability theory is proposed to improve the healthy rate of monkeys in a troop generation process. Meanwhile, the processes of harmony ladder climb and scanning watch jump are proposed and given in detail. Finally, Xinghai NO.1 Bridge in Dalian is implemented to demonstrate the effectiveness of TAMA. The final results obtained by TAMA are compared with those of the original monkey algorithm and EFI3 measurement, which show that TAMA can improve computational efficiency and get a better sensor configuration.

  6. Frequency wavenumber design of spiral macro fiber composite directional transducers

    NASA Astrophysics Data System (ADS)

    Carrara, Matteo; Ruzzene, Massimo

    2015-04-01

    This work is focused on design and testing of a novel class of transducers for Structural Health Monitoring (SHM), able to perform directional interrogation of plate-like structures. These transducers leverage guided waves (GWs), and in particular Lamb waves, that have emerged as a very prominent option for assessing the state of a structure during operation. GW-SHM approaches greatly benefit from the use of transducers with controllable directional characteristics, so that selective scanning of a surface can be performed to locate damage, impacts, or cracks. In the concepts that we propose, continuous beam steering and directional actuation are achieved through proper selection of the excitation frequency. The design procedure takes advantage of the wavenumber representation of the device, and formulates the problem using a Fourier-based approach. The active layer of the transducer is made of piezoelectric fibers embedded into an epoxy matrix, allowing the device to be flexible, and thus suitable for application on non{ at surfaces. Proper shaping of the electrodes pattern through a compensation function allows taking into account the anisotropy level introduced by the active layer. The resulting spiral frequency steerable acoustic actuator is a configuration that features (i) enhanced performance, (ii) reduced complexity, and (iii) reduced hardware requirements of such devices.

  7. Quantitative Damage Detection and Sparse Sensor Array Optimization of Carbon Fiber Reinforced Resin Composite Laminates for Wind Turbine Blade Structural Health Monitoring

    PubMed Central

    Li, Xiang; Yang, Zhibo; Chen, Xuefeng

    2014-01-01

    The active structural health monitoring (SHM) approach for the complex composite laminate structures of wind turbine blades (WTBs), addresses the important and complicated problem of signal noise. After illustrating the wind energy industry's development perspectives and its crucial requirement for SHM, an improved redundant second generation wavelet transform (IRSGWT) pre-processing algorithm based on neighboring coefficients is introduced for feeble signal denoising. The method can avoid the drawbacks of conventional wavelet methods that lose information in transforms and the shortcomings of redundant second generation wavelet (RSGWT) denoising that can lead to error propagation. For large scale WTB composites, how to minimize the number of sensors while ensuring accuracy is also a key issue. A sparse sensor array optimization of composites for WTB applications is proposed that can reduce the number of transducers that must be used. Compared to a full sixteen transducer array, the optimized eight transducer configuration displays better accuracy in identifying the correct position of simulated damage (mass of load) on composite laminates with anisotropic characteristics than a non-optimized array. It can help to guarantee more flexible and qualified monitoring of the areas that more frequently suffer damage. The proposed methods are verified experimentally on specimens of carbon fiber reinforced resin composite laminates. PMID:24763210

  8. Gen-2 RFID compatible, zero down-time, programmable mechanical strain-monitors and mechanical impact detectors

    NASA Astrophysics Data System (ADS)

    Chakrabartty, Shantanu; Feng, Tao; Aono, Kenji

    2013-04-01

    A key challenge in structural health monitoring (SHM) sensors embedded inside civil structures is that elec- tronics need to operate continuously such that mechanical events of interest can be detected and appropriately analyzed. Continuous operation however requires a continuous source of energy which cannot be guaranteed using conventional energy scavenging techniques. The paper describes a hybrid energy scavenging SHM sensor which experiences zero down-time in monitoring mechanical events of interest. At the core of the proposed sensor is an analog floating-gate storage technology that can be precisely programmed at nano-watt and pico- watt power levels. This facilitates self-powered, non-volatile data logging of the mechanical events of interest by scavenging energy directly from the mechanical events itself. Remote retrieval of the stored data is achieved using a commercial off-the-shelf Gen-2 radio-frequency identification (RFID) reader which periodically reads an electronic product code (EPC) that encapsulates the sensor data. The Gen-2 interface also facilitates in simultaneous remote access to multiple sensors and also facilitates in determining the range and orientation of the sensor. The architecture of the sensor is based on a token-ring topology which enables sensor channels to be dynamically added or deleted through software control.

  9. Near Real-Time Probabilistic Damage Diagnosis Using Surrogate Modeling and High Performance Computing

    NASA Technical Reports Server (NTRS)

    Warner, James E.; Zubair, Mohammad; Ranjan, Desh

    2017-01-01

    This work investigates novel approaches to probabilistic damage diagnosis that utilize surrogate modeling and high performance computing (HPC) to achieve substantial computational speedup. Motivated by Digital Twin, a structural health management (SHM) paradigm that integrates vehicle-specific characteristics with continual in-situ damage diagnosis and prognosis, the methods studied herein yield near real-time damage assessments that could enable monitoring of a vehicle's health while it is operating (i.e. online SHM). High-fidelity modeling and uncertainty quantification (UQ), both critical to Digital Twin, are incorporated using finite element method simulations and Bayesian inference, respectively. The crux of the proposed Bayesian diagnosis methods, however, is the reformulation of the numerical sampling algorithms (e.g. Markov chain Monte Carlo) used to generate the resulting probabilistic damage estimates. To this end, three distinct methods are demonstrated for rapid sampling that utilize surrogate modeling and exploit various degrees of parallelism for leveraging HPC. The accuracy and computational efficiency of the methods are compared on the problem of strain-based crack identification in thin plates. While each approach has inherent problem-specific strengths and weaknesses, all approaches are shown to provide accurate probabilistic damage diagnoses and several orders of magnitude computational speedup relative to a baseline Bayesian diagnosis implementation.

  10. Target sequence accessibility limits activation-induced cytidine deaminase activity in primary mediastinal B-cell lymphoma.

    PubMed

    Popov, Sergey W; Moldenhauer, Gerhard; Wotschke, Beate; Brüderlein, Silke; Barth, Thomas F; Dorsch, Karola; Ritz, Olga; Möller, Peter; Leithäuser, Frank

    2007-07-15

    Activation-induced cytidine deaminase (AID) initiates somatic hypermutation (SHM) and class switch recombination (CSR) in activated B lymphocytes and is potentially implicated in genomic instability of B-cell malignancies. For unknown reasons, B-cell neoplasms often lack SHM and CSR in spite of high AID expression. Here, we show that primary mediastinal B-cell lymphoma (PMBL), an immunoglobulin (Ig)-negative lymphoma that possesses hypermutated, class-switched Ig genes, expresses high levels of AID with an intact primary structure but does not do CSR in 14 of 16 cases analyzed. Absence of CSR coincided with low Ig germ-line transcription, whereas high level germ-line transcription was observed only in those two cases with active CSR. Interleukin-4/CD40L costimulation induced CSR and a marked up-regulation of germ-line transcription in the PMBL-derived cell line MedB-1. In the PMBL cell line Karpas 1106P, CSR was not inducible and germ-line transcription remained low on stimulation. However, Karpas 1106P, but not MedB-1, had ongoing SHM of the Ig gene and BCL6. These genes were transcribed in Karpas 1106P, whereas transcription was undetectable or low in MedB-1 cells. Thus, accessibility of the target sequences seems to be a major limiting factor for AID-dependent somatic gene diversification in PMBL.

  11. Variations in local elastic modulus along the length of the aorta as observed by use of a scanning haptic microscope (SHM).

    PubMed

    Moriwaki, Takeshi; Oie, Tomonori; Takamizawa, Keiichi; Murayama, Yoshinobu; Fukuda, Toru; Omata, Sadao; Kanda, Keiichi; Nakayama, Yasuhide

    2011-12-01

    Variations in microscopic elastic structures along the entire length of canine aorta were evaluated by use of a scanning haptic microscope (SHM). The total aorta from the aortic arch to the abdominal aorta was divided into 6 approximately equal segments. After embedding the aorta in agar, it was cut into horizontal circumferential segments to obtain disk-like agar portions containing ring-like samples of aorta with flat surfaces (thickness, approximately 1 mm). The elastic modulus and topography of the samples under no-load conditions were simultaneously measured along the entire thickness of the wall by SHM by using a probe with a diameter of 5 μm and a spatial resolution of 2 μm at a rate of 0.3 s/point. The elastic modulus of the wall was the highest on the side of the luminal surface and decreased gradually toward the adventitial side. This tendency was similar to that of the change in the elastin fiber content. During the evaluation of the mid-portion of each tunica media segment, the highest elastic modulus (40.8 ± 3.5 kPa) was identified at the thoracic section of the aorta that had the highest density of elastic fibers. Under no-load conditions, portions of the aorta with high elastin density have a high elastic modulus.

  12. Characterization of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Shanghai, China: molecular and cytogenetic characteristics, IgV gene restriction and hypermutation patterns.

    PubMed

    Irons, Richard D; Le, Anh; Bao, Liming; Zhu, Xiongzeng; Ryder, John; Wang, Xiao Qin; Ji, Meirong; Chen, Yan; Wu, Xichun; Lin, Guowei

    2009-12-01

    The clinical, cytogenetic and molecular features of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a disease previously considered to be rare in Asia, were examined in consecutive series of 70 cases diagnosed by our laboratory over a 30-month period. Clonal abnormalities were observed in 80% of CLL/SLL cases using a combination of conventional cytogenetic and fluorescence in situ hybridization (FISH) analysis. Those involving 14q32/IGH were the most frequent (24 cases), followed by trisomy 12 and 11q abnormalities. IgV(H) gene usage was non-random with over-representation of V(H)4-34, V(H)3-23 and a previously unreported increase in V(H)3-48 gene use. Somatic hypermutation (SHM) of IgV(H) germline sequences was observed in 56.5% of cases with stereotyped patterns of SHM observed in V(H)4-34 heavy chain complimentary-determining (HCDR1) and framework region CFR2 sequences. These findings in a Chinese population suggest subtle geographical differences in IgV(H) gene usage while the remarkably specific pattern of SHM suggest that a relatively limited set of antigens may be involved in the development of this disease worldwide. IgV(H) gene mutation status was a significant predictor of initial survival in CLL/SLL. However, an influence of karyotype on prognosis was not observed.

  13. Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3′ regulatory region

    PubMed Central

    Rouaud, Pauline; Saintamand, Alexis; Saad, Faten; Carrion, Claire; Lecardeur, Sandrine; Cogné, Michel

    2014-01-01

    Classical class-switch recombination (cCSR) substitutes the Cμ gene with Cγ, Cε, or Cα, thereby generating IgG, IgE, or IgA classes, respectively. This activation-induced deaminase (AID)–driven process is controlled by the IgH 3′ regulatory region (3′RR). Regulation of rare IgD CSR events has been enigmatic. We show that μδCSR occurs in mouse mesenteric lymph node (MLN) B cells and is AID-dependent. AID attacks differ from those in cCSR because they are not accompanied by extensive somatic hypermutation (SHM) of targeted regions and because repaired junctions exhibit features of the alternative end-joining (A-EJ) pathway. In contrast to cCSR and SHM, μδCSR is 3′RR-independent, as its absence affects neither breakpoint locations in Sμ- and Sδ-like (σδ) nor mutation patterns at Sμ-σδ junctions. Although mutations occur in the immediate proximity of the μδ junctions, SHM is absent distal to the junctions within both Sμ and rearranged VDJ regions. In conclusion, μδCSR is active in MLNs, occurs independently of 3′RR-driven assembly, and is even dramatically increased in 3′RR-deficient mice, further showing that its regulation differs from cCSR. PMID:24752300

  14. On damage diagnosis for a wind turbine blade using pattern recognition

    NASA Astrophysics Data System (ADS)

    Dervilis, N.; Choi, M.; Taylor, S. G.; Barthorpe, R. J.; Park, G.; Farrar, C. R.; Worden, K.

    2014-03-01

    With the increased interest in implementation of wind turbine power plants in remote areas, structural health monitoring (SHM) will be one of the key cards in the efficient establishment of wind turbines in the energy arena. Detection of blade damage at an early stage is a critical problem, as blade failure can lead to a catastrophic outcome for the entire wind turbine system. Experimental measurements from vibration analysis were extracted from a 9 m CX-100 blade by researchers at Los Alamos National Laboratory (LANL) throughout a full-scale fatigue test conducted at the National Renewable Energy Laboratory (NREL) and National Wind Technology Center (NWTC). The blade was harmonically excited at its first natural frequency using a Universal Resonant EXcitation (UREX) system. In the current study, machine learning algorithms based on Artificial Neural Networks (ANNs), including an Auto-Associative Neural Network (AANN) based on a standard ANN form and a novel approach to auto-association with Radial Basis Functions (RBFs) networks are used, which are optimised for fast and efficient runs. This paper introduces such pattern recognition methods into the wind energy field and attempts to address the effectiveness of such methods by combining vibration response data with novelty detection techniques.

  15. Oversampling in virtual visual sensors as a means to recover higher modes of vibration

    NASA Astrophysics Data System (ADS)

    Shariati, Ali; Schumacher, Thomas

    2015-03-01

    Vibration-based structural health monitoring (SHM) techniques require modal information from the monitored structure in order to estimate the location and severity of damage. Natural frequencies also provide useful information to calibrate finite element models. There are several types of physical sensors that can measure the response over a range of frequencies. For most of those sensors however, accessibility, limitation of measurement points, wiring, and high system cost represent major challenges. Recent optical sensing approaches offer advantages such as easy access to visible areas, distributed sensing capabilities, and comparatively inexpensive data recording while having no wiring issues. In this research we propose a novel methodology to measure natural frequencies of structures using digital video cameras based on virtual visual sensors (VVS). In our initial study where we worked with commercially available inexpensive digital video cameras we found that for multiple degrees of freedom systems it is difficult to detect all of the natural frequencies simultaneously due to low quantization resolution. In this study we show how oversampling enabled by the use of high-end high-frame-rate video cameras enable recovering all of the three natural frequencies from a three story lab-scale structure.

  16. The effect of time synchronization of wireless sensors on the modal analysis of structures

    NASA Astrophysics Data System (ADS)

    Krishnamurthy, V.; Fowler, K.; Sazonov, E.

    2008-10-01

    Driven by the need to reduce the installation cost and maintenance cost of structural health monitoring (SHM) systems, wireless sensor networks (WSNs) are becoming increasingly popular. Perfect time synchronization amongst the wireless sensors is a key factor enabling the use of low-cost, low-power WSNs for structural health monitoring applications based on output-only modal analysis of structures. In this paper we present a theoretical framework for analysis of the impact created by time delays in the measured system response on the reconstruction of mode shapes using the popular frequency domain decomposition (FDD) technique. This methodology directly estimates the change in mode shape values based on sensor synchronicity. We confirm the proposed theoretical model by experimental validation in modal identification experiments performed on an aluminum beam. The experimental validation was performed using a wireless intelligent sensor and actuator network (WISAN) which allows for close time synchronization between sensors (0.6-10 µs in the tested configuration) and guarantees lossless data delivery under normal conditions. The experimental results closely match theoretical predictions and show that even very small delays in output response impact the mode shapes.

  17. In-flight fiber optic acoustic emission sensor (FAESense) system for the real time detection, localization, and classification of damage in composite aircraft structures

    NASA Astrophysics Data System (ADS)

    Mendoza, Edgar; Prohaska, John; Kempen, Connie; Esterkin, Yan; Sun, Sunjian

    2013-05-01

    Acoustic emission sensing is a leading structural health monitoring technique use for the early warning detection of structural damage associated with impacts, cracks, fracture, and delaminations in advanced materials. Current AE systems based on electronic PZT transducers suffer from various limitations that prevent its wide dynamic use in practical avionics and aerospace applications where weight, size and power are critical for operation. This paper describes progress towards the development of a wireless in-flight distributed fiber optic acoustic emission monitoring system (FAESense™) suitable for the onboard-unattended detection, localization, and classification of damage in avionics and aerospace structures. Fiber optic AE sensors offer significant advantages over its counterpart electronic AE sensors by using a high-density array of micron-size AE transducers distributed and multiplex over long lengths of a standard single mode optical fiber. Immediate SHM applications are found in commercial and military aircraft, helicopters, spacecraft, wind mil turbine blades, and in next generation weapon systems, as well as in the petrochemical and aerospace industries, civil structures, power utilities, and a wide spectrum of other applications.

  18. Piezoelectric wafer active sensors under gamma radiation exposure toward applications for structural health monitoring of nuclear dry cask storage systems

    NASA Astrophysics Data System (ADS)

    Faisal Haider, Mohammad; Mei, Hanfei; Lin, Bin; Yu, Lingyu; Giurgiutiu, Victor; Lam, Poh-Sang; Verst, Christopher

    2018-03-01

    Structural health monitoring (SHM) is in urgent need and must be integrated into the nuclear-spent fuel storage systems to guarantee the safe operation. The dry cask storage system (DCSS) is such storage facility, which is licensed for temporary storage for nuclear-spent fuel at the independent spent fuel storage installations (ISFSIs) for certain predetermined period of time. Gamma radiation is one of the major radiation sources near DCSS. Therefore, a detailed experimental investigation was completed on the gamma radiation endurance of piezoelectric wafer active sensors (PWAS) transducers for SHM applications to the DCSS system. The irradiation test was done in a Co-60 gamma irradiator. Lead Zirconate Titanate (PZT) and Gallium Orthophosphate (GaPO4) PWAS transducers were exposed to 40.7 kGy gamma radiation. Total radiation dose was achieved in two different radiation dose rates: (a) slower radiation rate at 0.1 kGy/hr for 20 hours (b) accelerated radiation rate at 1.233 kGy/hr for 32 hours. The total cumulative radiation dose of 40.7 kGy is equivalent to 45 years of operation in DCSS system. Electro-mechanical impedance and admittance (EMIA) signatures and electrical capacitance were measured to evaluate the PWAS performance after each gamma radiation exposure. The change in resonance frequency of PZT-PWAS transducer for both in-plane and thickness mode was observed. The GaPO4-PWAS EMIA spectra do not show a significant shift in resonance frequency after gamma irradiation exposure. Radiation endurance of new high-temperature HPZ-HiT PWAS transducer was also evaluated. The HPZ-HiT transducers were exposed to gamma radiation at 1.233 kGy/hr for 160 hours with 80 hours interval. Therefore, the total accumulated gamma radiation dose is 184 kGy. No significant change in impedance spectra was observed due to gamma radiation exposure.

  19. Financial performance of the teaching pharmacies in Isfahan: an economic evaluation

    PubMed Central

    Sabzghabaee, A.M.; Etebari, M.; Sajjadi, H.; Badri, Sh.; Hosseini-Biuki, S.M.; Sheikhaboumasoudi, R.

    2009-01-01

    Teaching pharmacies are amongst the important cornerstones of a healthcare system for drug supplying, pharmacy education and pharmacy practice research. Assessment of the Iranian healthcare system costs shows that after personnel charges, drug outlay is the second expensive factor. This great financial mass requires integral audit and management in order to provide costumers satisfaction in addition to financial viability. Teaching pharmacies are required to realize financial viability as well as providing several educational and drug servicing goals, which makes microeconomic analysis important. The aim of this study was to evaluate the financial performance of the teaching pharmacies affiliated with the Isfahan University of Medical Sciences (with the abrreviated names as: SHM, ISJ, AZH for the confidentialiy of the financial data). This is a descriptive and cross-sectional study done in 2008. The target pharmacies of this study were all the 3 teaching pharmacies affiliated with the Isfahan University of Medical Sciences. The data collecting template was prepared using the standard scientific methods according to the goals of this research The goals also nominated necessary items needed in economic profit evaluation. The data collection template was completed by reference to the teaching pharmacies financial documents and reports, used as a base for calculating the total income and the total costs in 2007-2008 financial year. The difference between these two balances showed the value of profits or loss. The profit/cost ratio was also calculated, using the proportion of the total income to the total costs. The collected data was statistically analyzed using the Excel software (Microsoft 2007). For the financial year 2007-2008, the difference between the total income and the total costs was -831.6 million Rials (excess costs to income) for the SHM pharmacy, + 25.4 billion Rials for the ISJ pharmacy and -429.5 million Rials for the AZH pharmacy. According to our findings there is a strong requirement to improve the financial performance of all the three teaching pharmacies while maintaining a high standardard of teaching and educational affairs. PMID:21589804

  20. Financial performance of the teaching pharmacies in Isfahan: an economic evaluation.

    PubMed

    Sabzghabaee, A M; Etebari, M; Sajjadi, H; Badri, Sh; Hosseini-Biuki, S M; Sheikhaboumasoudi, R

    2009-07-01

    Teaching pharmacies are amongst the important cornerstones of a healthcare system for drug supplying, pharmacy education and pharmacy practice research. Assessment of the Iranian healthcare system costs shows that after personnel charges, drug outlay is the second expensive factor. This great financial mass requires integral audit and management in order to provide costumers satisfaction in addition to financial viability. Teaching pharmacies are required to realize financial viability as well as providing several educational and drug servicing goals, which makes microeconomic analysis important. The aim of this study was to evaluate the financial performance of the teaching pharmacies affiliated with the Isfahan University of Medical Sciences (with the abrreviated names as: SHM, ISJ, AZH for the confidentialiy of the financial data). This is a descriptive and cross-sectional study done in 2008. The target pharmacies of this study were all the 3 teaching pharmacies affiliated with the Isfahan University of Medical Sciences. The data collecting template was prepared using the standard scientific methods according to the goals of this research The goals also nominated necessary items needed in economic profit evaluation. The data collection template was completed by reference to the teaching pharmacies financial documents and reports, used as a base for calculating the total income and the total costs in 2007-2008 financial year. The difference between these two balances showed the value of profits or loss. The profit/cost ratio was also calculated, using the proportion of the total income to the total costs. The collected data was statistically analyzed using the Excel software (Microsoft 2007). For the financial year 2007-2008, the difference between the total income and the total costs was -831.6 million Rials (excess costs to income) for the SHM pharmacy, + 25.4 billion Rials for the ISJ pharmacy and -429.5 million Rials for the AZH pharmacy. According to our findings there is a strong requirement to improve the financial performance of all the three teaching pharmacies while maintaining a high standardard of teaching and educational affairs.

  1. Time-domain fiber loop ringdown sensor and sensor network

    NASA Astrophysics Data System (ADS)

    Kaya, Malik

    Optical fibers have been mostly used in fiber optic communications, imaging optics, sensing technology, etc. Fiber optic sensors have gained increasing attention for scientific and structural health monitoring (SHM) applications. In this study, fiber loop ringdown (FLRD) sensors were fabricated for scientific, SHM, and sensor networking applications. FLRD biosensors were fabricated for both bulk refractive index (RI)- and surface RI-based DNA sensing and one type of bacteria sensing. Furthermore, the effect of glucose oxidase (GOD) immobilization at the sensor head on sensor performance was evaluated for both glucose and synthetic urine solutions with glucose concentration between 0.1% and 10%. Detection sensitivities of the glucose sensors were achieved as low as 0.05%. For chemical sensing, heavy water, ranging from 97% to 10%, and several elemental solutions were monitored by using the FLRD chemical sensors. Bulk index-based FLRD sensing showed that trace elements can be detected in deionized water. For physical sensing, water and cracking sensors were fabricated and embedded into concrete. A partially-etched single-mode fiber (SMF) was embedded into a concrete bar for water monitoring while a bare SMF without any treatment was directly embedded into another concrete bar for monitoring cracks. Furthermore, detection sensitivities of water and crack sensors were investigated as 10 ml water and 0.5 mm surface crack width, respectively. Additionally fiber loop ringdown-fiber Bragg grating temperature sensors were developed in the laboratory; two sensor units for water, crack, and temperature sensing were deployed into a concrete cube in a US Department of Energy test bed (Miami, FL). Multi-sensor applications in a real concrete structure were accomplished by testing the six FLRD sensors. As a final stage, a sensor network was assembled by multiplexing two or three FLRD sensors in series and parallel. Additionally, two FLRD sensors were combined in series and parallel by using a 2x1 micro-electromechanical system optical switch to control sensors individually. For both configurations, contributions of each sensor to two or three coupled signals were simulated theoretically. Results show that numerous FLRD sensors can be connected in different configurations, and a sensor network can be built up for multi-function sensing applications.

  2. Utilization of wireless structural health monitoring as decision making tools for a condition and reliability-based assessment of railroad bridges

    NASA Astrophysics Data System (ADS)

    Flanigan, Katherine A.; Johnson, Nephi R.; Hou, Rui; Ettouney, Mohammed; Lynch, Jerome P.

    2017-04-01

    The ability to quantitatively assess the condition of railroad bridges facilitates objective evaluation of their robustness in the face of hazard events. Of particular importance is the need to assess the condition of railroad bridges in networks that are exposed to multiple hazards. Data collected from structural health monitoring (SHM) can be used to better maintain a structure by prompting preventative (rather than reactive) maintenance strategies and supplying quantitative information to aid in recovery. To that end, a wireless monitoring system is validated and installed on the Harahan Bridge which is a hundred-year-old long-span railroad truss bridge that crosses the Mississippi River near Memphis, TN. This bridge is exposed to multiple hazards including scour, vehicle/barge impact, seismic activity, and aging. The instrumented sensing system targets non-redundant structural components and areas of the truss and floor system that bridge managers are most concerned about based on previous inspections and structural analysis. This paper details the monitoring system and the analytical method for the assessment of bridge condition based on automated data-driven analyses. Two primary objectives of monitoring the system performance are discussed: 1) monitoring fatigue accumulation in critical tensile truss elements; and 2) monitoring the reliability index values associated with sub-system limit states of these members. Moreover, since the reliability index is a scalar indicator of the safety of components, quantifiable condition assessment can be used as an objective metric so that bridge owners can make informed damage mitigation strategies and optimize resource management on single bridge or network levels.

  3. Lamb wave propagation in Z-pin reinforced co-cured composite pi-joints

    NASA Astrophysics Data System (ADS)

    Swenson, Eric D.; Soni, Som R.; Kapoor, Hitesh

    2010-04-01

    This paper presents an initial study on Lamb wave propagation characteristics in z-pin reinforced, co-cured composite pi-joints for the purposes of structural health monitoring (SHM). Pi-joint test articles were designed and created to replicate a co-cured, all composite skin-spar joint found within a typical aircraft wing structure. Because pi-joints exhibit various complex damage modes, formal studies are required if SHM systems are to be developed to monitor these types of joints for potential damage. Experiments were conducted on a undamaged (healthy) and damaged test articles where Lamb waves were excited using one lead zirconate titanate (PZT) transducer. A three-dimensional (3D) scanning laser Doppler vibrometer (LDV) was used to collect high-density scans of both the in-plane and out-of-plane velocity measurements. In the damaged test article, where delamination, matrix cracking, and fiber breakage can clearly be seen, changes in both the fundamental antisymmetric A0 and symmetric S0 Lamb wave modes are apparent. In both test articles, the effects of narrow geometry, discontinuity due to the attachment of the web, and thickness has detectable effects on Lamb wave propagation. From the comparisons between Lamb waves propagating through the undamaged and damaged test articles, it is clear that damage can be detected using Lamb waves in z-pin reinforced, co-cured composite pi-joints for this case of extensive damage.

  4. Wireless sensor placement for structural monitoring using information-fusing firefly algorithm

    NASA Astrophysics Data System (ADS)

    Zhou, Guang-Dong; Yi, Ting-Hua; Xie, Mei-Xi; Li, Hong-Nan

    2017-10-01

    Wireless sensor networks (WSNs) are promising technology in structural health monitoring (SHM) applications for their low cost and high efficiency. The limited wireless sensors and restricted power resources in WSNs highlight the significance of optimal wireless sensor placement (OWSP) during designing SHM systems to enable the most useful information to be captured and to achieve the longest network lifetime. This paper presents a holistic approach, including an optimization criterion and a solution algorithm, for optimally deploying self-organizing multi-hop WSNs on large-scale structures. The combination of information effectiveness represented by the modal independence and the network performance specified by the network connectivity and network lifetime is first formulated to evaluate the performance of wireless sensor configurations. Then, an information-fusing firefly algorithm (IFFA) is developed to solve the OWSP problem. The step sizes drawn from a Lévy distribution are adopted to drive fireflies toward brighter individuals. Following the movement with Lévy flights, information about the contributions of wireless sensors to the objective function as carried by the fireflies is fused and applied to move inferior wireless sensors to better locations. The reliability of the proposed approach is verified via a numerical example on a long-span suspension bridge. The results demonstrate that the evaluation criterion provides a good performance metric of wireless sensor configurations, and the IFFA outperforms the simple discrete firefly algorithm.

  5. On modelling three-dimensional piezoelectric smart structures with boundary spectral element method

    NASA Astrophysics Data System (ADS)

    Zou, Fangxin; Aliabadi, M. H.

    2017-05-01

    The computational efficiency of the boundary element method in elastodynamic analysis can be significantly improved by employing high-order spectral elements for boundary discretisation. In this work, for the first time, the so-called boundary spectral element method is utilised to formulate the piezoelectric smart structures that are widely used in structural health monitoring (SHM) applications. The resultant boundary spectral element formulation has been validated by the finite element method (FEM) and physical experiments. The new formulation has demonstrated a lower demand on computational resources and a higher numerical stability than commercial FEM packages. Comparing to the conventional boundary element formulation, a significant reduction in computational expenses has been achieved. In summary, the boundary spectral element formulation presented in this paper provides a highly efficient and stable mathematical tool for the development of SHM applications.

  6. Damage classification and estimation in experimental structures using time series analysis and pattern recognition

    NASA Astrophysics Data System (ADS)

    de Lautour, Oliver R.; Omenzetter, Piotr

    2010-07-01

    Developed for studying long sequences of regularly sampled data, time series analysis methods are being increasingly investigated for the use of Structural Health Monitoring (SHM). In this research, Autoregressive (AR) models were used to fit the acceleration time histories obtained from two experimental structures: a 3-storey bookshelf structure and the ASCE Phase II Experimental SHM Benchmark Structure, in undamaged and limited number of damaged states. The coefficients of the AR models were considered to be damage-sensitive features and used as input into an Artificial Neural Network (ANN). The ANN was trained to classify damage cases or estimate remaining structural stiffness. The results showed that the combination of AR models and ANNs are efficient tools for damage classification and estimation, and perform well using small number of damage-sensitive features and limited sensors.

  7. Epigenetics of the antibody response

    PubMed Central

    Li, Guideng; Zan, Hong; Xu, Zhenming; Casali, Paolo

    2013-01-01

    Epigenetic marks, such as DNA methylation, histone posttranslational modifications and microRNAs, are induced in B cells by the same stimuli that drive the antibody response. They play major roles in regulating somatic hypermutation (SHM), class switch DNA recombination (CSR) and differentiation to plasma cells or long-lived memory B cells. Histone modifications target the CSR and, possibly, SHM machinery to the immunoglobulin locus; they together with DNA methylation and microRNAs modulate the expression of critical elements of that machinery, such as AID, as well as factors central to plasma cell differentiation, such as Blimp-1. These inducible B cell-intrinsic epigenetic marks instruct the maturation of antibody responses. Their dysregulation plays an important role in aberrant antibody responses to foreign antigens, such as those of microbial pathogens, and self-antigens, such those targeted in autoimmunity, and B cell neoplasias. PMID:23643790

  8. Cosmic CARNage I: on the calibration of galaxy formation models

    NASA Astrophysics Data System (ADS)

    Knebe, Alexander; Pearce, Frazer R.; Gonzalez-Perez, Violeta; Thomas, Peter A.; Benson, Andrew; Asquith, Rachel; Blaizot, Jeremy; Bower, Richard; Carretero, Jorge; Castander, Francisco J.; Cattaneo, Andrea; Cora, Sofía A.; Croton, Darren J.; Cui, Weiguang; Cunnama, Daniel; Devriendt, Julien E.; Elahi, Pascal J.; Font, Andreea; Fontanot, Fabio; Gargiulo, Ignacio D.; Helly, John; Henriques, Bruno; Lee, Jaehyun; Mamon, Gary A.; Onions, Julian; Padilla, Nelson D.; Power, Chris; Pujol, Arnau; Ruiz, Andrés N.; Srisawat, Chaichalit; Stevens, Adam R. H.; Tollet, Edouard; Vega-Martínez, Cristian A.; Yi, Sukyoung K.

    2018-04-01

    We present a comparison of nine galaxy formation models, eight semi-analytical, and one halo occupation distribution model, run on the same underlying cold dark matter simulation (cosmological box of comoving width 125h-1 Mpc, with a dark-matter particle mass of 1.24 × 109h-1M⊙) and the same merger trees. While their free parameters have been calibrated to the same observational data sets using two approaches, they nevertheless retain some `memory' of any previous calibration that served as the starting point (especially for the manually tuned models). For the first calibration, models reproduce the observed z = 0 galaxy stellar mass function (SMF) within 3σ. The second calibration extended the observational data to include the z = 2 SMF alongside the z ˜ 0 star formation rate function, cold gas mass, and the black hole-bulge mass relation. Encapsulating the observed evolution of the SMF from z = 2 to 0 is found to be very hard within the context of the physics currently included in the models. We finally use our calibrated models to study the evolution of the stellar-to-halo mass (SHM) ratio. For all models, we find that the peak value of the SHM relation decreases with redshift. However, the trends seen for the evolution of the peak position as well as the mean scatter in the SHM relation are rather weak and strongly model dependent. Both the calibration data sets and model results are publicly available.

  9. Vibration-based monitoring and diagnostics using compressive sensing

    NASA Astrophysics Data System (ADS)

    Ganesan, Vaahini; Das, Tuhin; Rahnavard, Nazanin; Kauffman, Jeffrey L.

    2017-04-01

    Vibration data from mechanical systems carry important information that is useful for characterization and diagnosis. Standard approaches rely on continually streaming data at a fixed sampling frequency. For applications involving continuous monitoring, such as Structural Health Monitoring (SHM), such approaches result in high volume data and rely on sensors being powered for prolonged durations. Furthermore, for spatial resolution, structures are instrumented with a large array of sensors. This paper shows that both volume of data and number of sensors can be reduced significantly by applying Compressive Sensing (CS) in vibration monitoring applications. The reduction is achieved by using random sampling and capitalizing on the sparsity of vibration signals in the frequency domain. Preliminary experimental results validating CS-based frequency recovery are also provided. By exploiting the sparsity of mode shapes, CS can also enable efficient spatial reconstruction using fewer spatially distributed sensors. CS can thereby reduce the cost and power requirement of sensing as well as streamline data storage and processing in monitoring applications. In well-instrumented structures, CS can enable continued monitoring in case of sensor or computational failures.

  10. The application of compressed sensing to long-term acoustic emission-based structural health monitoring

    NASA Astrophysics Data System (ADS)

    Cattaneo, Alessandro; Park, Gyuhae; Farrar, Charles; Mascareñas, David

    2012-04-01

    The acoustic emission (AE) phenomena generated by a rapid release in the internal stress of a material represent a promising technique for structural health monitoring (SHM) applications. AE events typically result in a discrete number of short-time, transient signals. The challenge associated with capturing these events using classical techniques is that very high sampling rates must be used over extended periods of time. The result is that a very large amount of data is collected to capture a phenomenon that rarely occurs. Furthermore, the high energy consumption associated with the required high sampling rates makes the implementation of high-endurance, low-power, embedded AE sensor nodes difficult to achieve. The relatively rare occurrence of AE events over long time scales implies that these measurements are inherently sparse in the spike domain. The sparse nature of AE measurements makes them an attractive candidate for the application of compressed sampling techniques. Collecting compressed measurements of sparse AE signals will relax the requirements on the sampling rate and memory demands. The focus of this work is to investigate the suitability of compressed sensing techniques for AE-based SHM. The work explores estimating AE signal statistics in the compressed domain for low-power classification applications. In the event compressed classification finds an event of interest, ι1 norm minimization will be used to reconstruct the measurement for further analysis. The impact of structured noise on compressive measurements is specifically addressed. The suitability of a particular algorithm, called Justice Pursuit, to increase robustness to a small amount of arbitrary measurement corruption is investigated.

  11. A novel HVSR approach on structural heath monitoring for structural vulnerability assesement

    NASA Astrophysics Data System (ADS)

    Pentaris, Fragkiskos P.; Papadopoulos, Ilias

    2014-05-01

    This work suggests a novel approach for vulnerability assessment in structural health monitoring (SHM) through Horizontal to Vertical Spectral Ratio (HVSR) method. Acceleration recordings of different age concrete buildings [1] are analyzed using the conventional method for estimation of fundamental frequency in SHM (Fast Furrier Transform-FFT method). The results of frequency spectrum are verified theoretically (mass and stiffness matrices models) but also by practical techniques applied in real structure data, for the estimation of structural resonance frequencies [2-4]. The same recordings are analyzed by HVSR method and study the differences and the similarities of both methods (FFT and HVSR) under earthquake excitation. Both methods can reveal resonance frequencies and amplitude of buildings under study, with great detail and efficiency in terms of ease of deployment, computation, cost and time. Furthermore HVSR recordings of strong seismic motion are compared with HVSR recordings of ambient noise for the case study buildings. The similarities of HVSR recordings (between earthquake and ambient noise) reveal the same analogy in HVSR spectrum. This enables a simple HVSR noise recording in a building to present the same information with an earthquake HVSR recording that are much rarer. This study presents a novel index which compute the increase of HVSR between floors and correlates the increasing rate with the structural vulnerability of the specific building. The main idea is that this HVSR rate index is strongly related with the differential acceleration (between floors), a determinant measurement for SHM assessment in concrete buildings. Experimental data verify the above HVSR rise index by presentation of higher HVSR rise in older buildings (with visible cracks in beams, damage and stress in their structure) than other younger buildings without any visible damage. Acknowledgments This work was supported in part by the ARCHEMEDES III Program of the Ministry of Education of Greece and the European Union in the framework of the project entitled «Interdisciplinary Multi-Scale Research of Earthquake Physics and Seismotectonics at the front of the Hellenic Arc (IMPACT-ARC) ». References [1] F. P. Pentaris, J. Stonham, and J. P. Makris, "A review of the state-of-the-art of wireless SHM systems and an experimental set-up towards an improved design," presented at the EUROCON, 2013 IEEE, Zagreb, 2013. [2] R. Ditommaso, M. Mucciarelli, S. Parolai, and M. Picozzi, "Monitoring the structural dynamic response of a masonry tower: Comparing classical and time-frequency analyses," Bulletin of Earthquake Engineering, vol. 10, pp. 1221-1235, 2012. [3] Sungkono, D. D. Warnana, Triwulan, and W. Utama, "Evaluation of Buildings Strength from Microtremor Analyses " International Journal of Civil & Environmental Engineering IJCEE-IJENS, vol. 11, 2011. [4] L.-L. Hong and W.-L. Hwang, "Empirical formula for fundamental vibration periods of reinforced concrete buildings in Taiwan," Earthquake Engineering & Structural Dynamics, vol. 29, pp. 327-337, 2000.

  12. Crack identification for reinforced concrete using PZT based smart rebar active sensing diagnostic network

    NASA Astrophysics Data System (ADS)

    Song, N. N.; Wu, F.

    2016-04-01

    An active sensing diagnostic system using PZT based smart rebar for SHM of RC structure has been currently under investigation. Previous test results showed that the system could detect the de-bond of concrete from reinforcement, and the diagnostic signals were increased exponentially with the de-bonding size. Previous study also showed that the smart rebar could function well like regular reinforcement to undertake tension stresses. In this study, a smart rebar network has been used to detect the crack damage of concrete based on guided waves. Experimental test has been carried out for the study. In the test, concrete beams with 2 reinforcements have been built. 8 sets of PZT elements were mounted onto the reinforcement bars in an optimized way to form an active sensing diagnostic system. A 90 kHz 5-cycle Hanning-windowed tone burst was used as input. Multiple cracks have been generated on the concrete structures. Through the guided bulk waves propagating in the structures from actuators and sensors mounted from different bars, crack damage could be detected clearly. Cases for both single and multiple cracks were tested. Different crack depths from the surface and different crack numbers have been studied. Test result shows that the amplitude of sensor output signals is deceased linearly with a propagating crack, and is decreased exponentially with increased crack numbers. From the study, the active sensing diagnostic system using PZT based smart rebar network shows a promising way to provide concrete crack damage information through the "talk" among sensors.

  13. Fatigue damage prognosis of internal delamination in composite plates under cyclic compression loadings using affine arithmetic as uncertainty propagation tool

    NASA Astrophysics Data System (ADS)

    Gbaguidi, Audrey J.-M.

    Structural health monitoring (SHM) has become indispensable for reducing maintenance costs and increasing the in-service capacity of a structure. The increased use of lightweight composite materials in aircraft structures drastically increased the effects of fatigue induced damage on their critical structural components and thus the necessity to predict the remaining life of those components. Damage prognosis, one of the least investigated fields in SHM, uses the current damage state of the system to forecast its future performance by estimating the expected loading environments. A successful damage prediction model requires the integration of technologies in areas like measurements, materials science, mechanics of materials, and probability theories, but most importantly the quantification of uncertainty in all these areas. In this study, Affine Arithmetic is used as a method for incorporating the uncertainties due to the material properties into the fatigue life prognosis of composite plates subjected to cyclic compressive loadings. When loadings are compressive in nature, the composite plates undergo repeated buckling-unloading of the delaminated layer which induces mixed modes I and II states of stress at the tip of the delamination in the plates. The Kardomateas model-based prediction law is used to predict the growth of the delamination, while the integration of the effects of the uncertainties for modes I and II coefficients in the fatigue life prediction model is handled using Affine arithmetic. The Mode I and Mode II interlaminar fracture toughness and fatigue characterization of the composite plates are first experimentally studied to obtain the material coefficients and fracture toughness, respectively. Next, these obtained coefficients are used in the Kardomateas law to predict the delamination lengths in the composite plates while using Affine Arithmetic to handle their uncertainties. At last, the fatigue characterization of the composite plates during compressive-buckling loadings is experimentally studied, and the delamination lengths obtained are compared with the predicted values to check the performance of Affine Arithmetic as an uncertainty propagation tool.

  14. Structural Health Monitoring Analysis for the Orbiter Wing Leading Edge

    NASA Technical Reports Server (NTRS)

    Yap, Keng C.

    2010-01-01

    This viewgraph presentation reviews Structural Health Monitoring Analysis for the Orbiter Wing Leading Edge. The Wing Leading Edge Impact Detection System (WLE IDS) and the Impact Analysis Process are also described to monitor WLE debris threats. The contents include: 1) Risk Management via SHM; 2) Hardware Overview; 3) Instrumentation; 4) Sensor Configuration; 5) Debris Hazard Monitoring; 6) Ascent Response Summary; 7) Response Signal; 8) Distribution of Flight Indications; 9) Probabilistic Risk Analysis (PRA); 10) Model Correlation; 11) Impact Tests; 12) Wing Leading Edge Modeling; 13) Ascent Debris PRA Results; and 14) MM/OD PRA Results.

  15. Regulation of AID, the B-cell genome mutator

    PubMed Central

    Keim, Celia; Kazadi, David; Rothschild, Gerson; Basu, Uttiya

    2013-01-01

    The mechanisms by which B cells somatically engineer their genomes to generate the vast diversity of antibodies required to challenge the nearly infinite number of antigens that immune systems encounter are of tremendous clinical and academic interest. The DNA cytidine deaminase activation-induced deaminase (AID) catalyzes two of these mechanisms: class switch recombination (CSR) and somatic hypermutation (SHM). Recent discoveries indicate a significant promiscuous targeting of this B-cell mutator enzyme genome-wide. Here we discuss the various regulatory elements that control AID activity and prevent AID from inducing genomic instability and thereby initiating oncogenesis. PMID:23307864

  16. A Wireless Passive Sensing System for Displacement/Strain Measurement in Reinforced Concrete Members

    PubMed Central

    Ozbey, Burak; Erturk, Vakur B.; Demir, Hilmi Volkan; Altintas, Ayhan; Kurc, Ozgur

    2016-01-01

    In this study, we show a wireless passive sensing system embedded in a reinforced concrete member successfully being employed for the measurement of relative displacement and strain in a simply supported beam experiment. The system utilizes electromagnetic coupling between the transceiver antenna located outside the beam, and the sensing probes placed on the reinforcing bar (rebar) surface inside the beam. The probes were designed in the form of a nested split-ring resonator, a metamaterial-based structure chosen for its compact size and high sensitivity/resolution, which is at µm/microstrains level. Experiments were performed in both the elastic and plastic deformation cases of steel rebars, and the sensing system was demonstrated to acquire telemetric data in both cases. The wireless measurement results from multiple probes are compared with the data obtained from the strain gages, and an excellent agreement is observed. A discrete time measurement where the system records data at different force levels is also shown. Practical issues regarding the placement of the sensors and accurate recording of data are discussed. The proposed sensing technology is demonstrated to be a good candidate for wireless structural health monitoring (SHM) of reinforced concrete members by its high sensitivity and wide dynamic range. PMID:27070615

  17. A Review of Passive RFID Tag Antenna-Based Sensors and Systems for Structural Health Monitoring Applications.

    PubMed

    Zhang, Jun; Tian, Gui Yun; Marindra, Adi M J; Sunny, Ali Imam; Zhao, Ao Bo

    2017-01-29

    In recent few years, the antenna and sensor communities have witnessed a considerable integration of radio frequency identification (RFID) tag antennas and sensors because of the impetus provided by internet of things (IoT) and cyber-physical systems (CPS). Such types of sensor can find potential applications in structural health monitoring (SHM) because of their passive, wireless, simple, compact size, and multimodal nature, particular in large scale infrastructures during their lifecycle. The big data from these ubiquitous sensors are expected to generate a big impact for intelligent monitoring. A remarkable number of scientific papers demonstrate the possibility that objects can be remotely tracked and intelligently monitored for their physical/chemical/mechanical properties and environment conditions. Most of the work focuses on antenna design, and significant information has been generated to demonstrate feasibilities. Further information is needed to gain deep understanding of the passive RFID antenna sensor systems in order to make them reliable and practical. Nevertheless, this information is scattered over much literature. This paper is to comprehensively summarize and clearly highlight the challenges and state-of-the-art methods of passive RFID antenna sensors and systems in terms of sensing and communication from system point of view. Future trends are also discussed. The future research and development in UK are suggested as well.

  18. Applying robust variant of Principal Component Analysis as a damage detector in the presence of outliers

    NASA Astrophysics Data System (ADS)

    Gharibnezhad, Fahit; Mujica, Luis E.; Rodellar, José

    2015-01-01

    Using Principal Component Analysis (PCA) for Structural Health Monitoring (SHM) has received considerable attention over the past few years. PCA has been used not only as a direct method to identify, classify and localize damages but also as a significant primary step for other methods. Despite several positive specifications that PCA conveys, it is very sensitive to outliers. Outliers are anomalous observations that can affect the variance and the covariance as vital parts of PCA method. Therefore, the results based on PCA in the presence of outliers are not fully satisfactory. As a main contribution, this work suggests the use of robust variant of PCA not sensitive to outliers, as an effective way to deal with this problem in SHM field. In addition, the robust PCA is compared with the classical PCA in the sense of detecting probable damages. The comparison between the results shows that robust PCA can distinguish the damages much better than using classical one, and even in many cases allows the detection where classic PCA is not able to discern between damaged and non-damaged structures. Moreover, different types of robust PCA are compared with each other as well as with classical counterpart in the term of damage detection. All the results are obtained through experiments with an aircraft turbine blade using piezoelectric transducers as sensors and actuators and adding simulated damages.

  19. Multiple damage identification on a wind turbine blade using a structural neural system

    NASA Astrophysics Data System (ADS)

    Kirikera, Goutham R.; Schulz, Mark J.; Sundaresan, Mannur J.

    2007-04-01

    A large number of sensors are required to perform real-time structural health monitoring (SHM) to detect acoustic emissions (AE) produced by damage growth on large complicated structures. This requires a large number of high sampling rate data acquisition channels to analyze high frequency signals. To overcome the cost and complexity of having such a large data acquisition system, a structural neural system (SNS) was developed. The SNS reduces the required number of data acquisition channels and predicts the location of damage within a sensor grid. The sensor grid uses interconnected sensor nodes to form continuous sensors. The combination of continuous sensors and the biomimetic parallel processing of the SNS tremendously reduce the complexity of SHM. A wave simulation algorithm (WSA) was developed to understand the flexural wave propagation in composite structures and to utilize the code for developing the SNS. Simulation of AE responses in a plate and comparison with experimental results are shown in the paper. The SNS was recently tested by a team of researchers from University of Cincinnati and North Carolina A&T State University during a quasi-static proof test of a 9 meter long wind turbine blade at the National Renewable Energy Laboratory (NREL) test facility in Golden, Colorado. Twelve piezoelectric sensor nodes were used to form four continuous sensors to monitor the condition of the blade during the test. The four continuous sensors are used as inputs to the SNS. There are only two analog output channels of the SNS, and these signals are digitized and analyzed in a computer to detect damage. In the test of the wind turbine blade, multiple damages were identified and later verified by sectioning of the blade. The results of damage identification using the SNS during this proof test will be shown in this paper. Overall, the SNS is very sensitive and can detect damage on complex structures with ribs, joints, and different materials, and the system relatively inexpensive and simple to implement on large structures.

  20. Review on pressure sensors for structural health monitoring

    NASA Astrophysics Data System (ADS)

    Sikarwar, Samiksha; Satyendra; Singh, Shakti; Yadav, Bal Chandra

    2017-12-01

    This paper reports the state of art in a variety of pressure and the detailed study of various matrix based pressure sensors. The performances of the bridges, buildings, etc. are threatened by earthquakes, material degradations, and other environmental effects. Structural health monitoring (SHM) is crucial to protect the people and also for assets planning. This study is a contribution in developing the knowledge about self-sensing smart materials and structures for the construction industry. It deals with the study of self-sensing as well as mechanical and electrical properties of different matrices based on pressure sensors. The relationships among the compression, tensile strain, and crack length with electrical resistance change are also reviewed.

  1. Development of a structural health monitoring (SHM) guidebook for critical bridge structures.

    DOT National Transportation Integrated Search

    2013-07-01

    A recently completed study suggests that approximately 25% of them are either structurally deficient : or functionally obsolete (FHWA, 2007). Therefore, the Federal Highway Administration (FHWA) : and the Oklahoma Transportation Center (OTC) have mad...

  2. Bridge Health Monitoring Using a Machine Learning Strategy

    DOT National Transportation Integrated Search

    2017-01-01

    The goal of this project was to cast the SHM problem within a statistical pattern recognition framework. Techniques borrowed from speaker recognition, particularly speaker verification, were used as this discipline deals with problems very similar to...

  3. Acoustic Emission Measurement with Fiber Bragg Gratings for Structure Health Monitoring

    NASA Technical Reports Server (NTRS)

    Banks, Curtis E.; Walker, James L.; Russell, Sam; Roth, Don; Mabry, Nehemiah; Wilson, Melissa

    2010-01-01

    Structural Health monitoring (SHM) is a way of detecting and assessing damage to large scale structures. Sensors used in SHM for aerospace structures provide real time data on new and propagating damage. One type of sensor that is typically used is an acoustic emission (AE) sensor that detects the acoustic emissions given off from a material cracking or breaking. The use of fiber Bragg grating (FBG) sensors to provide acoustic emission data for damage detection is studied. In this research, FBG sensors are used to detect acoustic emissions of a material during a tensile test. FBG sensors were placed as a strain sensor (oriented parallel to applied force) and as an AE sensor (oriented perpendicular to applied force). A traditional AE transducer was used to collect AE data to compare with the FBG data. Preliminary results show that AE with FBGs can be a viable alternative to traditional AE sensors.

  4. Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution

    NASA Astrophysics Data System (ADS)

    Senavirathne, Gayan; Bertram, Jeffrey G.; Jaszczur, Malgorzata; Chaurasiya, Kathy R.; Pham, Phuong; Mak, Chi H.; Goodman, Myron F.; Rueda, David

    2015-12-01

    Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of immunoglobulin variable (IgV) and switch region (IgS) DNA. Using single-molecule FRET, we show that AID binds to transcribed dsDNA and translocates unidirectionally in concert with RNA polymerase (RNAP) on moving transcription bubbles, while increasing the fraction of stalled bubbles. AID scans randomly when constrained in an 8 nt model bubble. When unconstrained on single-stranded (ss) DNA, AID moves in random bidirectional short slides/hops over the entire molecule while remaining bound for ~5 min. Our analysis distinguishes dynamic scanning from static ssDNA creasing. That AID alone can track along with RNAP during transcription and scan within stalled transcription bubbles suggests a mechanism by which AID can initiate SHM and CSR when properly regulated, yet when unregulated can access non-Ig genes and cause cancer.

  5. Functional requirements of AID's higher order structures and their interaction with RNA-binding proteins.

    PubMed

    Mondal, Samiran; Begum, Nasim A; Hu, Wenjun; Honjo, Tasuku

    2016-03-15

    Activation-induced cytidine deaminase (AID) is essential for the somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes. Although both the N and C termini of AID have unique functions in DNA cleavage and recombination, respectively, during SHM and CSR, their molecular mechanisms are poorly understood. Using a bimolecular fluorescence complementation (BiFC) assay combined with glycerol gradient fractionation, we revealed that the AID C terminus is required for a stable dimer formation. Furthermore, AID monomers and dimers form complexes with distinct heterogeneous nuclear ribonucleoproteins (hnRNPs). AID monomers associate with DNA cleavage cofactor hnRNP K whereas AID dimers associate with recombination cofactors hnRNP L, hnRNP U, and Serpine mRNA-binding protein 1. All of these AID/ribonucleoprotein associations are RNA-dependent. We propose that AID's structure-specific cofactor complex formations differentially contribute to its DNA-cleavage and recombination functions.

  6. Internet forums: a self-help approach for individuals with schizophrenia?

    PubMed

    Haker, H; Lauber, C; Rössler, W

    2005-12-01

    To study if and how online self-help forums for individuals with schizophrenia are used. We analysed 1200 postings of 576 users in 12 international schizophrenia forums regarding communicative skills [fields of interest and self-help mechanisms (SHM)]. The forums were predominantly used by affected individuals, few relatives or friends. The fields of interest of the users concern daily problems of the illness like symptoms and emotional involvement with the illness. Self-help mechanisms mostly used are disclosure and providing information. Emotional interaction e.g. empathy or gratitude were comparatively rare. Individuals suffering from schizophrenia participate in online self-help forums using the same SHM, discussing similar topics as do individuals with other psychiatric disorders as well as not affected relatives and caregivers. Therefore, this tool seems to be a useful approach to cope with alienation and isolation, albeit only a small number of schizophrenia forums are found in the Internet.

  7. Direct detection of light ''Ge-phobic'' exothermic dark matter

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gelmini, Graciela B.; Georgescu, Andreea; Huh, Ji-Haeng, E-mail: gelmini@physics.ucla.edu, E-mail: a.georgescu@physics.ucla.edu, E-mail: jhhuh@physics.ucla.edu

    2014-07-01

    We present comparisons of direct dark matter (DM) detection data for light WIMPs with exothermic scattering with nuclei (exoDM), both assuming the Standard Halo Model (SHM) and in a halo model–independent manner. Exothermic interactions favor light targets, thus reducing the importance of upper limits derived from xenon targets, the most restrictive of which is at present the LUX limit. In our SHM analysis the CDMS-II-Si and CoGeNT regions become allowed by these bounds, however the recent SuperCDMS limit rejects both regions for exoDM with isospin-conserving couplings. An isospin-violating coupling of the exoDM, in particular one with a neutron to protonmore » coupling ratio of -0.8 (which we call ''Ge-phobic''), maximally reduces the DM coupling to germanium and allows the CDMS-II-Si region to become compatible with all bounds. This is also clearly shown in our halo-independent analysis.« less

  8. Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins

    PubMed Central

    Mondal, Samiran; Begum, Nasim A.; Hu, Wenjun; Honjo, Tasuku

    2016-01-01

    Activation-induced cytidine deaminase (AID) is essential for the somatic hypermutation (SHM) and class-switch recombination (CSR) of Ig genes. Although both the N and C termini of AID have unique functions in DNA cleavage and recombination, respectively, during SHM and CSR, their molecular mechanisms are poorly understood. Using a bimolecular fluorescence complementation (BiFC) assay combined with glycerol gradient fractionation, we revealed that the AID C terminus is required for a stable dimer formation. Furthermore, AID monomers and dimers form complexes with distinct heterogeneous nuclear ribonucleoproteins (hnRNPs). AID monomers associate with DNA cleavage cofactor hnRNP K whereas AID dimers associate with recombination cofactors hnRNP L, hnRNP U, and Serpine mRNA-binding protein 1. All of these AID/ribonucleoprotein associations are RNA-dependent. We propose that AID’s structure-specific cofactor complex formations differentially contribute to its DNA-cleavage and recombination functions. PMID:26929374

  9. Investigation on the use of artificial neural networks to overcome the effects of environmental and operational changes on guided waves monitoring

    NASA Astrophysics Data System (ADS)

    El Mountassir, M.; Yaacoubi, S.; Dahmene, F.

    2015-07-01

    Intelligent feature extraction and advanced signal processing techniques are necessary for a better interpretation of ultrasonic guided waves signals either in structural health monitoring (SHM) or in nondestructive testing (NDT). Such signals are characterized by at least multi-modal and dispersive components. In addition, in SHM, these signals are closely vulnerable to environmental and operational conditions (EOCs), and can be severely affected. In this paper we investigate the use of Artificial Neural Network (ANN) to overcome these effects and to provide a reliable damage detection method with a minimal of false indications. An experimental case of study (full scale pipe) is presented. Damages sizes have been increased and their shapes modified in different steps. Various parameters such as the number of inputs and the number of hidden neurons were studied to find the optimal configuration of the neural network.

  10. Embedding human annoyance rate models in wireless smart sensors for assessing the influence of subway train-induced ambient vibration

    NASA Astrophysics Data System (ADS)

    Sun, Ke; Zhang, Wei; Ding, Huaping; Kim, Robin E.; Spencer, Billie F., Jr.

    2016-10-01

    The operation of subway trains induces ambient vibrations, which may cause annoyance and other adverse effects on humans, eventually leading to physical, physiological, and psychological problems. In this paper, the human annoyance rate (HAR) models, used to assess the human comfort under the subway train-induced ambient vibrations, were deduced and the calibration curves for 5 typical use circumstances were addressed. An autonomous measurement system, based on the Imote2, wireless smart sensor (WSS) platform, plus the SHM-H, high-sensitivity accelerometer board, was developed for the HAR assessment. The calibration curves were digitized and embedded in the computational core of the WSS unit. Experimental validation was conducted, using the developed system on a large underground reinforced concrete frame structure adjoining the subway station. The ambient acceleration of both basement floors was measured; the embedded computation was implemented and the HAR assessment results were wirelessly transmitted to the central server, all by the WSS unit. The HAR distributions of the testing areas were identified, and the extent to which both basements will be influenced by the close-up subway-train’s operation, in term of the 5 typical use circumstances, were quantitatively assessed. The potential of the WSS-based autonomous system for the fast environment impact assessment of the subway train-induced ambient vibration was well demonstrated.

  11. Nonlinear ultrasonic stimulated thermography for damage assessment in isotropic fatigued structures

    NASA Astrophysics Data System (ADS)

    Fierro, Gian Piero Malfense; Calla', Danielle; Ginzburg, Dmitri; Ciampa, Francesco; Meo, Michele

    2017-09-01

    Traditional non-destructive evaluation (NDE) and structural health monitoring (SHM) systems are used to analyse that a structure is free of any harmful damage. However, these techniques still lack sensitivity to detect the presence of material micro-flaws in the form of fatigue damage and often require time-consuming procedures and expensive equipment. This research work presents a novel "nonlinear ultrasonic stimulated thermography" (NUST) method able to overcome some of the limitations of traditional linear ultrasonic/thermography NDE-SHM systems and to provide a reliable, rapid and cost effective estimation of fatigue damage in isotropic materials. Such a hybrid imaging approach combines the high sensitivity of nonlinear acoustic/ultrasonic techniques to detect micro-damage, with local defect frequency selection and infrared imaging. When exciting structures with an optimised frequency, nonlinear elastic waves are observed and higher frictional work at the fatigue damaged area is generated due to clapping and rubbing of the crack faces. This results in heat at cracked location that can be measured using an infrared camera. A Laser Vibrometer (LV) was used to evaluate the extent that individual frequency components contribute to the heating of the damage region by quantifying the out-of-plane velocity associated with the fundamental and second order harmonic responses. It was experimentally demonstrated the relationship between a nonlinear ultrasound parameter (βratio) of the material nonlinear response to the actual temperature rises near the crack. These results demonstrated that heat generation at damaged regions could be amplified by exciting at frequencies that provide nonlinear responses, thus improving the imaging of material damage and the reliability of NUST in a quick and reproducible manner.

  12. Damage identification of a TLP floating wind turbine by meta-heuristic algorithms

    NASA Astrophysics Data System (ADS)

    Ettefagh, M. M.

    2015-12-01

    Damage identification of the offshore floating wind turbine by vibration/dynamic signals is one of the important and new research fields in the Structural Health Monitoring (SHM). In this paper a new damage identification method is proposed based on meta-heuristic algorithms using the dynamic response of the TLP (Tension-Leg Platform) floating wind turbine structure. The Genetic Algorithms (GA), Artificial Immune System (AIS), Particle Swarm Optimization (PSO), and Artificial Bee Colony (ABC) are chosen for minimizing the object function, defined properly for damage identification purpose. In addition to studying the capability of mentioned algorithms in correctly identifying the damage, the effect of the response type on the results of identification is studied. Also, the results of proposed damage identification are investigated with considering possible uncertainties of the structure. Finally, for evaluating the proposed method in real condition, a 1/100 scaled experimental setup of TLP Floating Wind Turbine (TLPFWT) is provided in a laboratory scale and the proposed damage identification method is applied to the scaled turbine.

  13. Dual demodulation interferometer with two-wave mixing in GaAs photorefractive crystal

    NASA Astrophysics Data System (ADS)

    Zhenzhen, Zhang; Zhongqing, Jia; Guangrong, Ji; Qiwu, Wang

    2018-07-01

    A dual demodulation interferometer with two-wave mixing (TWM) in the GaAs photorefractive crystal (PRC) is proposed and experimentally demonstrated. The GaAs PRC has tiny temperature change under high voltage thus not requiring thermoelectric cooler (TEC) to stabilize the temperature, and adaptive to low frequency fluctuation below 200 Hz. The system is an unbalanced TWM interferometer, which could demodulate the phase change both space variation and wavelength shift induced by strain. Two demodulation modes' formulas are provided in theory respectively. Experimental results have been tested and compared with theoretical analysis, demonstrating that it is a practical and flexible system for detection of mechanical vibration or structure health monitoring (SHM) in engineering by selecting different demodulation mode.

  14. Structural health monitoring for bolt loosening via a non-invasive vibro-haptics human-machine cooperative interface

    NASA Astrophysics Data System (ADS)

    Pekedis, Mahmut; Mascerañas, David; Turan, Gursoy; Ercan, Emre; Farrar, Charles R.; Yildiz, Hasan

    2015-08-01

    For the last two decades, developments in damage detection algorithms have greatly increased the potential for autonomous decisions about structural health. However, we are still struggling to build autonomous tools that can match the ability of a human to detect and localize the quantity of damage in structures. Therefore, there is a growing interest in merging the computational and cognitive concepts to improve the solution of structural health monitoring (SHM). The main object of this research is to apply the human-machine cooperative approach on a tower structure to detect damage. The cooperation approach includes haptic tools to create an appropriate collaboration between SHM sensor networks, statistical compression techniques and humans. Damage simulation in the structure is conducted by releasing some of the bolt loads. Accelerometers are bonded to various locations of the tower members to acquire the dynamic response of the structure. The obtained accelerometer results are encoded in three different ways to represent them as a haptic stimulus for the human subjects. Then, the participants are subjected to each of these stimuli to detect the bolt loosened damage in the tower. Results obtained from the human-machine cooperation demonstrate that the human subjects were able to recognize the damage with an accuracy of 88 ± 20.21% and response time of 5.87 ± 2.33 s. As a result, it is concluded that the currently developed human-machine cooperation SHM may provide a useful framework to interact with abstract entities such as data from a sensor network.

  15. Analysis of IgV gene mutations in B cell chronic lymphocytic leukaemia according to antigen-driven selection identifies subgroups with different prognosis and usage of the canonical somatic hypermutation machinery.

    PubMed

    Degan, Massimo; Bomben, Riccardo; Bo, Michele Dal; Zucchetto, Antonella; Nanni, Paola; Rupolo, Maurizio; Steffan, Agostino; Attadia, Vincenza; Ballerini, Pier Ferruccio; Damiani, Daniela; Pucillo, Carlo; Poeta, Giovanni Del; Colombatti, Alfonso; Gattei, Valter

    2004-07-01

    Cases of B-cell chronic lymphocytic leukaemia (B-CLL) with mutated (M) IgV(H) genes have a better prognosis than unmutated (UM) cases. We analysed the IgV(H) mutational status of B-CLL according to the features of a canonical somatic hypermutation (SHM) process, correlating this data with survival. In a series of 141 B-CLLs, 124 cases were examined for IgV(H) gene per cent mutations and skewing of replacement/silent mutations in the framework/complementarity-determining regions as evidence of antigen-driven selection; this identified three B-CLL subsets: significantly mutated (sM), with evidence of antigen-driven selection, not significantly mutated (nsM) and UM, without such evidence and IgV(H) gene per cent mutations above or below the 2% cut-off. sM B-CLL patients had longer survival within the good prognosis subgroup that had more than 2% mutations of IgV(H) genes. sM, nsM and UM B-CLL were also characterized for the biased usage of IgV(H) families, intraclonal IgV(H) gene diversification, preference of mutations to target-specific nucleotides or hotspots, and for the expression of enzymes involved in SHM (translesion DNA polymerase zeta and eta and activation-induced cytidine deaminase). These findings indicate the activation of a canonical SHM process in nsM and sM B-CLLs and underscore the role of the antigen in defining the specific clinical and biological features of B-CLL.

  16. The use of an improved technique to reduce the variability of output voltage in real-time Fibre Bragg Grating based monitoring system

    NASA Astrophysics Data System (ADS)

    Vorathin, E.; Hafizi, Z. M.; Che Ghani, S. A.; Lim, K. S.; Aizzuddin, A. M.

    2017-10-01

    Fibre Bragg Grating (FBG) sensors have been widely utilized in the structural health monitoring (SHM) of structures. However, one of the main challenges of FBGs is the existence of inconsistency in output voltage during wavelength intensity demodulation utilizing photodetector (PD) to convert the light signal into digital voltage readings. Thus, the designation of this experimental work is to develop a robust FBG real-time monitoring system with the benefit of MATLAB graphical user interface (GUI) and voltage normalization algorithm to scale down the voltage inconsistency. Low-cost edge filter interrogation system has been practiced in the experimentation and splitter optical component is make use to reduce the intensity of the high power light source that leads to the formation of noise due to unwanted reflected wavelengths. The results revealed that with the advancement of the proposed monitoring system, the sensitivity of the FBG has been increased from 2.4 mV/N to 3.8 mV/N across the range of 50 N. The redundancy in output voltage variation data points has been reduced from 26 data/minute to 17 data/minute. The accuracy of the FBG in detecting the load induced falls in the acceptable range of total average error which is 1.38 %.

  17. Feasibility of Frequency-Modulated Wireless Transmission for a Multi-Purpose MEMS-Based Accelerometer

    PubMed Central

    Sabato, Alessandro; Feng, Maria Q.

    2014-01-01

    Recent advances in the Micro Electro-Mechanical System (MEMS) technology have made wireless MEMS accelerometers an attractive tool for Structural Health Monitoring (SHM) of civil engineering structures. To date, sensors' low sensitivity and accuracy—especially at very low frequencies—have imposed serious limitations for their application in monitoring large-sized structures. Conventionally, the MEMS sensor's analog signals are converted to digital signals before radio-frequency (RF) wireless transmission. The conversion can cause a low sensitivity to the important low-frequency and low-amplitude signals. To overcome this difficulty, the authors have developed a MEMS accelerometer system, which converts the sensor output voltage to a frequency-modulated signal before RF transmission. This is achieved by using a Voltage to Frequency Conversion (V/F) instead of the conventional Analog to Digital Conversion (ADC). In this paper, a prototype MEMS accelerometer system is presented, which consists of a transmitter and receiver circuit boards. The former is equipped with a MEMS accelerometer, a V/F converter and a wireless RF transmitter, while the latter contains an RF receiver and a F/V converter for demodulating the signal. The efficacy of the MEMS accelerometer system in measuring low-frequency and low-amplitude dynamic responses is demonstrated through extensive laboratory tests and experiments on a flow-loop pipeline. PMID:25198003

  18. Feasibility of frequency-modulated wireless transmission for a multi-purpose MEMS-based accelerometer.

    PubMed

    Sabato, Alessandro; Feng, Maria Q

    2014-09-05

    Recent advances in the Micro Electro-Mechanical System (MEMS) technology have made wireless MEMS accelerometers an attractive tool for Structural Health Monitoring (SHM) of civil engineering structures. To date, sensors' low sensitivity and accuracy--especially at very low frequencies--have imposed serious limitations for their application in monitoring large-sized structures. Conventionally, the MEMS sensor's analog signals are converted to digital signals before radio-frequency (RF) wireless transmission. The conversion can cause a low sensitivity to the important low-frequency and low-amplitude signals. To overcome this difficulty, the authors have developed a MEMS accelerometer system, which converts the sensor output voltage to a frequency-modulated signal before RF transmission. This is achieved by using a Voltage to Frequency Conversion (V/F) instead of the conventional Analog to Digital Conversion (ADC). In this paper, a prototype MEMS accelerometer system is presented, which consists of a transmitter and receiver circuit boards. The former is equipped with a MEMS accelerometer, a V/F converter and a wireless RF transmitter, while the latter contains an RF receiver and a F/V converter for demodulating the signal. The efficacy of the MEMS accelerometer system in measuring low-frequency and low-amplitude dynamic responses is demonstrated through extensive laboratory tests and experiments on a flow-loop pipeline.

  19. Composite Stress Rupture NDE Research and Development Project (Kevlar[R] and Carbon)

    NASA Technical Reports Server (NTRS)

    Saulsberry, Regor

    2010-01-01

    The objective was to develop and demonstrate nondestructive evaluation (NDE) techniques capable of assessing stress rupture related strength degradation for carbon composite pressure vessels, either in a structural health monitoring (SHM) or periodic inspection mode.

  20. Congenital ataxia and hemiplegic migraine with cerebral edema associated with a novel gain of function mutation in the calcium channel CACNA1A.

    PubMed

    García Segarra, Nuria; Gautschi, Ivan; Mittaz-Crettol, Laureane; Kallay Zetchi, Christine; Al-Qusairi, Lama; Van Bemmelen, Miguel Xavier; Maeder, Philippe; Bonafé, Luisa; Schild, Laurent; Roulet-Perez, Eliane

    2014-07-15

    Mutations in the CACNA1A gene, encoding the α1 subunit of the voltage-gated calcium channel Ca(V)2.1 (P/Q-type), have been associated with three neurological phenotypes: familial and sporadic hemiplegic migraine type 1 (FHM1, SHM1), episodic ataxia type 2 (EA2), and spinocerebellar ataxia type 6 (SCA6). We report a child with congenital ataxia, abnormal eye movements and developmental delay who presented severe attacks of hemiplegic migraine triggered by minor head traumas and associated with hemispheric swelling and seizures. Progressive cerebellar atrophy was also observed. Remission of the attacks was obtained with acetazolamide. A de novo 3 bp deletion was found in heterozygosity causing loss of a phenylalanine residue at position 1502, in one of the critical transmembrane domains of the protein contributing to the inner part of the pore. We characterized the electrophysiology of this mutant in a Xenopus oocyte in vitro system and showed that it causes gain of function of the channel. The mutant Ca(V)2.1 activates at lower voltage threshold than the wild type. These findings provide further evidence of this molecular mechanism as causative of FHM1 and expand the phenotypic spectrum of CACNA1A mutations with a child exhibiting severe SHM1 and non-episodic ataxia of congenital onset. Copyright © 2014 Elsevier B.V. All rights reserved.

  1. Historic Bim: a New Repository for Structural Health Monitoring

    NASA Astrophysics Data System (ADS)

    Banfi, F.; Barazzetti, L.; Previtali, M.; Roncoroni, F.

    2017-05-01

    Recent developments in Building Information Modelling (BIM) technologies are facilitating the management of historic complex structures using new applications. This paper proposes a generative method combining the morphological and typological aspects of the historic buildings (H-BIM), with a set of monitoring information. This combination of 3D digital survey, parametric modelling and monitoring datasets allows for the development of a system for archiving and visualizing structural health monitoring (SHM) data (Fig. 1). The availability of a BIM database allows one to integrate a different kind of data stored in different ways (e.g. reports, tables, graphs, etc.) with a representation directly connected to the 3D model of the structure with appropriate levels of detail (LoD). Data can be interactively accessed by selecting specific objects of the BIM, i.e. connecting the 3D position of the sensors installed with additional digital documentation. Such innovative BIM objects, which form a new BIM family for SHM, can be then reused in other projects, facilitating data archiving and exploitation of data acquired and processed. The application of advanced modeling techniques allows for the reduction of time and costs of the generation process, and support cooperation between different disciplines using a central workspace. However, it also reveals new challenges for parametric software and exchange formats. The case study presented is the medieval bridge Azzone Visconti in Lecco (Italy), in which multi-temporal vertical movements during load testing were integrated into H-BIM.

  2. Load identification approach based on basis pursuit denoising algorithm

    NASA Astrophysics Data System (ADS)

    Ginsberg, D.; Ruby, M.; Fritzen, C. P.

    2015-07-01

    The information of the external loads is of great interest in many fields of structural analysis, such as structural health monitoring (SHM) systems or assessment of damage after extreme events. However, in most cases it is not possible to measure the external forces directly, so they need to be reconstructed. Load reconstruction refers to the problem of estimating an input to a dynamic system when the system output and the impulse response functions are usually the knowns. Generally, this leads to a so called ill-posed inverse problem, which involves solving an underdetermined linear system of equations. For most practical applications it can be assumed that the applied loads are not arbitrarily distributed in time and space, at least some specific characteristics about the external excitation are known a priori. In this contribution this knowledge was used to develop a more suitable force reconstruction method, which allows identifying the time history and the force location simultaneously by employing significantly fewer sensors compared to other reconstruction approaches. The properties of the external force are used to transform the ill-posed problem into a sparse recovery task. The sparse solution is acquired by solving a minimization problem known as basis pursuit denoising (BPDN). The possibility of reconstructing loads based on noisy structural measurement signals will be demonstrated by considering two frequently occurring loading conditions: harmonic excitation and impact events, separately and combined. First a simulation study of a simple plate structure is carried out and thereafter an experimental investigation of a real beam is performed.

  3. A novel camera localization system for extending three-dimensional digital image correlation

    NASA Astrophysics Data System (ADS)

    Sabato, Alessandro; Reddy, Narasimha; Khan, Sameer; Niezrecki, Christopher

    2018-03-01

    The monitoring of civil, mechanical, and aerospace structures is important especially as these systems approach or surpass their design life. Often, Structural Health Monitoring (SHM) relies on sensing techniques for condition assessment. Advancements achieved in camera technology and optical sensors have made three-dimensional (3D) Digital Image Correlation (DIC) a valid technique for extracting structural deformations and geometry profiles. Prior to making stereophotogrammetry measurements, a calibration has to be performed to obtain the vision systems' extrinsic and intrinsic parameters. It means that the position of the cameras relative to each other (i.e. separation distance, cameras angle, etc.) must be determined. Typically, cameras are placed on a rigid bar to prevent any relative motion between the cameras. This constraint limits the utility of the 3D-DIC technique, especially as it is applied to monitor large-sized structures and from various fields of view. In this preliminary study, the design of a multi-sensor system is proposed to extend 3D-DIC's capability and allow for easier calibration and measurement. The suggested system relies on a MEMS-based Inertial Measurement Unit (IMU) and a 77 GHz radar sensor for measuring the orientation and relative distance of the stereo cameras. The feasibility of the proposed combined IMU-radar system is evaluated through laboratory tests, demonstrating its ability in determining the cameras position in space for performing accurate 3D-DIC calibration and measurements.

  4. 77 FR 24515 - Notice of Lodging of Consent Decree Pursuant to the Clean Water Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    ... America and the State of Tennessee v. the City of Memphis (``City''), Civil Action No. 2:10-CV- 02083-SHM... Decree represents a settlement of claims against the City of Memphis under [[Page 24516

  5. Development of A Low-Cost FPGA-Based Measurement System for Real-Time Processing of Acoustic Emission Data: Proof of Concept Using Control of Pulsed Laser Ablation in Liquids.

    PubMed

    Wirtz, Sebastian F; Cunha, Adauto P A; Labusch, Marc; Marzun, Galina; Barcikowski, Stephan; Söffker, Dirk

    2018-06-01

    Today, the demand for continuous monitoring of valuable or safety critical equipment is increasing in many industrial applications due to safety and economical requirements. Therefore, reliable in-situ measurement techniques are required for instance in Structural Health Monitoring (SHM) as well as process monitoring and control. Here, current challenges are related to the processing of sensor data with a high data rate and low latency. In particular, measurement and analyses of Acoustic Emission (AE) are widely used for passive, in-situ inspection. Advantages of AE are related to its sensitivity to different micro-mechanical mechanisms on the material level. However, online processing of AE waveforms is computationally demanding. The related equipment is typically bulky, expensive, and not well suited for permanent installation. The contribution of this paper is the development of a Field Programmable Gate Array (FPGA)-based measurement system using ZedBoard devlopment kit with Zynq-7000 system on chip for embedded implementation of suitable online processing algorithms. This platform comprises a dual-core Advanced Reduced Instruction Set Computer Machine (ARM) architecture running a Linux operating system and FPGA fabric. A FPGA-based hardware implementation of the discrete wavelet transform is realized to accelerate processing the AE measurements. Key features of the system are low cost, small form factor, and low energy consumption, which makes it suitable to serve as field-deployed measurement and control device. For verification of the functionality, a novel automatically realized adjustment of the working distance during pulsed laser ablation in liquids is established as an example. A sample rate of 5 MHz is achieved at 16 bit resolution.

  6. Gaussian mixture modeling of acoustic emissions for structural health monitoring of reinforced concrete structures

    NASA Astrophysics Data System (ADS)

    Farhidzadeh, Alireza; Dehghan-Niri, Ehsan; Salamone, Salvatore

    2013-04-01

    Reinforced Concrete (RC) has been widely used in construction of infrastructures for many decades. The cracking behavior in concrete is crucial due to the harmful effects on structural performance such as serviceability and durability requirements. In general, in loading such structures until failure, tensile cracks develop at the initial stages of loading, while shear cracks dominate later. Therefore, monitoring the cracking modes is of paramount importance as it can lead to the prediction of the structural performance. In the past two decades, significant efforts have been made toward the development of automated structural health monitoring (SHM) systems. Among them, a technique that shows promises for monitoring RC structures is the acoustic emission (AE). This paper introduces a novel probabilistic approach based on Gaussian Mixture Modeling (GMM) to classify AE signals related to each crack mode. The system provides an early warning by recognizing nucleation of numerous critical shear cracks. The algorithm is validated through an experimental study on a full-scale reinforced concrete shear wall subjected to a reversed cyclic loading. A modified conventional classification scheme and a new criterion for crack classification are also proposed.

  7. Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction

    PubMed Central

    Padilla, Jaume; Park, Young-Min; Welly, Rebecca J.; Scroggins, Rebecca J.; Britton, Steven L.; Koch, Lauren G.; Jenkins, Nathan T.; Crissey, Jacqueline M.; Zidon, Terese; Morris, E. Matthew; Meers, Grace M. E.; Thyfault, John P.

    2015-01-01

    Ovariectomized rodents model human menopause in that they rapidly gain weight, reduce spontaneous physical activity (SPA), and develop metabolic dysfunction, including insulin resistance. How contrasting aerobic fitness levels impacts ovariectomy (OVX)-associated metabolic dysfunction is not known. Female rats selectively bred for high and low intrinsic aerobic fitness [high-capacity runners (HCR) and low-capacity runners (LCR), respectively] were maintained under sedentary conditions for 39 wk. Midway through the observation period, OVX or sham (SHM) operations were performed providing HCR-SHM, HCR-OVX, LCR-SHM, and LCR-OVX groups. Glucose tolerance, energy expenditure, and SPA were measured before and 4 wk after surgery, while body composition via dual-energy X-ray absorptiometry and adipose tissue distribution, brown adipose tissue (BAT), and skeletal muscle phenotype, hepatic lipid content, insulin resistance via homeostatic assessment model of insulin resistance and AdipoIR, and blood lipids were assessed at death. Remarkably, HCR were protected from OVX-associated increases in adiposity and insulin resistance, observed only in LCR. HCR rats were ∼30% smaller, had ∼70% greater spontaneous physical activity (SPA), consumed ∼10% more relative energy, had greater skeletal muscle proliferator-activated receptor coactivator 1-alpha, and ∼40% more BAT. OVX did not increase energy intake and reduced SPA to the same extent in both HCR and LCR. LCR were particularly affected by an OVX-associated reduction in resting energy expenditure and experienced a reduction in relative BAT; resting energy expenditure correlated positively with BAT across all animals (r = 0.6; P < 0.001). In conclusion, despite reduced SPA following OVX, high intrinsic aerobic fitness protects against OVX-associated increases in adiposity and insulin resistance. The mechanism may involve preservation of resting energy expenditure. PMID:25608751

  8. Phosphatidylinositol 3-Kinase (PI3K) δ blockade increases genomic instability in B cells

    PubMed Central

    Compagno, Mara; Wang, Qi; Pighi, Chiara; Cheong, Taek-Chin; Meng, Fei-Long; Poggio, Teresa; Yeap, Leng-Siew; Karaca, Elif; Blasco, Rafael B.; Langellotto, Fernanda; Ambrogio, Chiara; Voena, Claudia; Wiestner, Adrian; Kasar, Siddha N.; Brown, Jennifer R.; Sun, Jing; Wu, Catherine J.; Gostissa, Monica; Alt, Frederick W.; Chiarle, Roberto

    2017-01-01

    Activation-induced cytidine deaminase (AID) is a B-cell specific enzyme that targets immunoglobulin (Ig) genes to initiate class switch recombination (CSR) and somatic hypermutation (SHM)1. Through off-target activity, however, AID has a much broader impact on genomic instability by initiating oncogenic chromosomal translocations and mutations involved in lymphoma development and progression2. AID expression is tightly regulated in B cells and its overexpression leads to enhanced genomic instability and lymphoma formation3. The phosphatidylinositol 3-kinase (PI3K) δ pathway plays a key role in AID regulation by suppressing its expression in B cells4. Novel drugs for leukemia or lymphoma therapy such as idelalisib, duvelisib or ibrutinib block PI3Kδ activity directly or indirectly5–8, potentially affecting AID expression and, consequently, genomic stability in B cells. Here we show that treatment of primary mouse B cells with idelalisib or duvelisib, and to a lesser extent ibrutinib, enhanced the expression of AID and increased somatic hypermutation (SHM) and chromosomal translocation frequency to the Igh locus and to several AID off-target sites. Both these effects were completely abrogated in AID deficient B cells. PI3Kδ inhibitors or ibrutinib increased the formation of AID-dependent tumors in pristane-treated mice. Consistently, PI3Kδ inhibitors enhanced AID expression and translocation frequency to IgH and AID off-target sites in human chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL) cell lines, and patients treated with idelalisib, but not ibrutinib, showed increased SHM in AID off-targets. In summary, we show that PI3Kδ or BTK inhibitors increase genomic instability in normal and neoplastic B cells by an AID-dependent mechanism, an effect that should be carefully considered as such inhibitors are administered for years to patients. PMID:28199309

  9. A Review of Passive RFID Tag Antenna-Based Sensors and Systems for Structural Health Monitoring Applications

    PubMed Central

    Zhang, Jun; Tian, Gui Yun; Marindra, Adi M. J.; Sunny, Ali Imam; Zhao, Ao Bo

    2017-01-01

    In recent few years, the antenna and sensor communities have witnessed a considerable integration of radio frequency identification (RFID) tag antennas and sensors because of the impetus provided by internet of things (IoT) and cyber-physical systems (CPS). Such types of sensor can find potential applications in structural health monitoring (SHM) because of their passive, wireless, simple, compact size, and multimodal nature, particular in large scale infrastructures during their lifecycle. The big data from these ubiquitous sensors are expected to generate a big impact for intelligent monitoring. A remarkable number of scientific papers demonstrate the possibility that objects can be remotely tracked and intelligently monitored for their physical/chemical/mechanical properties and environment conditions. Most of the work focuses on antenna design, and significant information has been generated to demonstrate feasibilities. Further information is needed to gain deep understanding of the passive RFID antenna sensor systems in order to make them reliable and practical. Nevertheless, this information is scattered over much literature. This paper is to comprehensively summarize and clearly highlight the challenges and state-of-the-art methods of passive RFID antenna sensors and systems in terms of sensing and communication from system point of view. Future trends are also discussed. The future research and development in UK are suggested as well. PMID:28146067

  10. Corrosion detection and evolution monitoring in reinforced concrete structures by the use of fiber Bragg grating sensor

    NASA Astrophysics Data System (ADS)

    Ali-Alvarez, S.; Ferdinand, P.; Magne, S.; Nogueira, R. P.

    2013-04-01

    Corrosion of reinforced bar (rebar) in concrete structures represents a major issue in civil engineering works, being its detection and evolution a challenge for the applied research. In this work, we present a new methodology to corrosion detection in reinforced concrete structures, by combining Fiber Bragg Grating (FBG) sensors with the electrochemical and physical properties of rebar in a simplified assembly. Tests in electrolytic solutions and concrete were performed for pitting and general corrosion. The proposed Structural Health Monitoring (SHM) methodology constitutes a direct corrosion measurement potentially useful to implement or improve Condition-Based Maintenance (CBM) program for civil engineering concrete structures.

  11. Impedance-based structural health monitoring of additive manufactured structures with embedded piezoelectric wafers

    NASA Astrophysics Data System (ADS)

    Scheyer, Austin G.; Anton, Steven R.

    2017-04-01

    Embedding sensors within additive manufactured (AM) structures gives the ability to develop smart structures that are capable of monitoring the mechanical health of a system. AM provides an opportunity to embed sensors within a structure during the manufacturing process. One major limitation of AM technology is the ability to verify the geometric and material properties of fabricated structures. Over the past several years, the electromechanical impedance (EMI) method for structural health monitoring (SHM) has been proven to be an effective method for sensing damage in structurers. The EMI method utilizes the coupling between the electrical and mechanical properties of a piezoelectric transducer to detect a change in the dynamic response of a structure. A piezoelectric device, usually a lead zirconate titanate (PZT) ceramic wafer, is bonded to a structure and the electrical impedance is measured across as range of frequencies. A change in the electrical impedance is directly correlated to changes made to the mechanical condition of the structure. In this work, the EMI method is employed on piezoelectric transducers embedded inside AM parts to evaluate the feasibility of performing SHM on parts fabricated using additive manufacturing. The fused deposition modeling (FDM) method is used to print specimens for this feasibility study. The specimens are printed from polylactic acid (PLA) in the shape of a beam with an embedded monolithic piezoelectric ceramic disc. The specimen is mounted as a cantilever while impedance measurements are taken using an HP 4194A impedance analyzer. Both destructive and nondestructive damage is simulated in the specimens by adding an end mass and drilling a hole near the free end of the cantilever, respectively. The Root Mean Square Deviation (RMSD) method is utilized as a metric for quantifying damage to the system. In an effort to determine a threshold for RMSD, the values are calculated for the variation associated with taking multiple measurements and with re-clamping the cantilever, and determined to be 0.154, and 3.125 respectively. The RMSD value of the cantilever with a 400 g end mass is 11.39, and the RMSD value of the cantilever with a 4 mm hole near the end is 12.15. From these results, it can be determined that the damaged cases have much higher RMSD values than the RMSD values associated with measurements and set up variability of the healthy structure.

  12. An Integrative Structural Health Monitoring System for the Local/Global Responses of a Large-Scale Irregular Building under Construction

    PubMed Central

    Park, Hyo Seon; Shin, Yunah; Choi, Se Woon; Kim, Yousok

    2013-01-01

    In this study, a practical and integrative SHM system was developed and applied to a large-scale irregular building under construction, where many challenging issues exist. In the proposed sensor network, customized energy-efficient wireless sensing units (sensor nodes, repeater nodes, and master nodes) were employed and comprehensive communications from the sensor node to the remote monitoring server were conducted through wireless communications. The long-term (13-month) monitoring results recorded from a large number of sensors (75 vibrating wire strain gauges, 10 inclinometers, and three laser displacement sensors) indicated that the construction event exhibiting the largest influence on structural behavior was the removal of bents that were temporarily installed to support the free end of the cantilevered members during their construction. The safety of each member could be confirmed based on the quantitative evaluation of each response. Furthermore, it was also confirmed that the relation between these responses (i.e., deflection, strain, and inclination) can provide information about the global behavior of structures induced from specific events. Analysis of the measurement results demonstrates the proposed sensor network system is capable of automatic and real-time monitoring and can be applied and utilized for both the safety evaluation and precise implementation of buildings under construction. PMID:23860317

  13. Evaluation of uncertainty in determination of neutral axis and deformed shape of beam structures : final report.

    DOT National Transportation Integrated Search

    2016-01-01

    With aging infrastructure, it becomes crucial to make informed decisions about maintenance and : preservation actions, as well as renewal of civil structures. Structural Health Monitoring (SHM) can be : an important aid in this decision process, but ...

  14. Fiber Bragg Grating Sensors toward Structural Health Monitoring in Composite Materials: Challenges and Solutions

    PubMed Central

    Kinet, Damien; Mégret, Patrice; Goossen, Keith W.; Qiu, Liang; Heider, Dirk; Caucheteur, Christophe

    2014-01-01

    Nowadays, smart composite materials embed miniaturized sensors for structural health monitoring (SHM) in order to mitigate the risk of failure due to an overload or to unwanted inhomogeneity resulting from the fabrication process. Optical fiber sensors, and more particularly fiber Bragg grating (FBG) sensors, outperform traditional sensor technologies, as they are lightweight, small in size and offer convenient multiplexing capabilities with remote operation. They have thus been extensively associated to composite materials to study their behavior for further SHM purposes. This paper reviews the main challenges arising from the use of FBGs in composite materials. The focus will be made on issues related to temperature-strain discrimination, demodulation of the amplitude spectrum during and after the curing process as well as connection between the embedded optical fibers and the surroundings. The main strategies developed in each of these three topics will be summarized and compared, demonstrating the large progress that has been made in this field in the past few years. PMID:24763215

  15. Direct detection of light “Ge-phobic” exothermic dark matter

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gelmini, Graciela B.; Georgescu, Andreea; Huh, Ji-Haeng

    2014-07-15

    We present comparisons of direct dark matter (DM) detection data for light WIMPs with exothermic scattering with nuclei (exoDM), both assuming the Standard Halo Model (SHM) and in a halo model — independent manner. Exothermic interactions favor light targets, thus reducing the importance of upper limits derived from xenon targets, the most restrictive of which is at present the LUX limit. In our SHM analysis the CDMS-II-Si and CoGeNT regions become allowed by these bounds, however the recent SuperCDMS limit rejects both regions for exoDM with isospin-conserving couplings. An isospin-violating coupling of the exoDM, in particular one with a neutronmore » to proton coupling ratio of −0.8 (which we call “Ge-phobic”), maximally reduces the DM coupling to germanium and allows the CDMS-II-Si region to become compatible with all bounds. This is also clearly shown in our halo-independent analysis.« less

  16. Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization.

    PubMed

    Francica, Joseph R; Sheng, Zizhang; Zhang, Zhenhai; Nishimura, Yoshiaki; Shingai, Masashi; Ramesh, Akshaya; Keele, Brandon F; Schmidt, Stephen D; Flynn, Barbara J; Darko, Sam; Lynch, Rebecca M; Yamamoto, Takuya; Matus-Nicodemos, Rodrigo; Wolinsky, David; Nason, Martha; Valiante, Nicholas M; Malyala, Padma; De Gregorio, Ennio; Barnett, Susan W; Singh, Manmohan; O'Hagan, Derek T; Koup, Richard A; Mascola, John R; Martin, Malcolm A; Kepler, Thomas B; Douek, Daniel C; Shapiro, Lawrence; Seder, Robert A

    2015-04-10

    Developing predictive animal models to assess how candidate vaccines and infection influence the ontogenies of Envelope (Env)-specific antibodies is critical for the development of an HIV vaccine. Here we use two nonhuman primate models to compare the roles of antigen persistence, diversity and innate immunity. We perform longitudinal analyses of HIV Env-specific B-cell receptor responses to SHIV(AD8) infection and Env protein vaccination with eight different adjuvants. A subset of the SHIV(AD8)-infected animals with higher viral loads and greater Env diversity show increased neutralization associated with increasing somatic hypermutation (SHM) levels over time. The use of adjuvants results in increased ELISA titres but does not affect the mean SHM levels or CDR H3 lengths. Our study shows how the ontogeny of Env-specific B cells can be tracked, and provides insights into the requirements for developing neutralizing antibodies that should facilitate translation to human vaccine studies.

  17. Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution

    PubMed Central

    Senavirathne, Gayan; Bertram, Jeffrey G.; Jaszczur, Malgorzata; Chaurasiya, Kathy R.; Pham, Phuong; Mak, Chi H.; Goodman, Myron F.; Rueda, David

    2015-01-01

    Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of immunoglobulin variable (IgV) and switch region (IgS) DNA. Using single-molecule FRET, we show that AID binds to transcribed dsDNA and translocates unidirectionally in concert with RNA polymerase (RNAP) on moving transcription bubbles, while increasing the fraction of stalled bubbles. AID scans randomly when constrained in an 8 nt model bubble. When unconstrained on single-stranded (ss) DNA, AID moves in random bidirectional short slides/hops over the entire molecule while remaining bound for ∼5 min. Our analysis distinguishes dynamic scanning from static ssDNA creasing. That AID alone can track along with RNAP during transcription and scan within stalled transcription bubbles suggests a mechanism by which AID can initiate SHM and CSR when properly regulated, yet when unregulated can access non-Ig genes and cause cancer. PMID:26681117

  18. Fatigue Performance of Ti-6Al-4V Additively Manufactured Specimens with Integrated Capillaries of an Embedded Structural Health Monitoring System

    PubMed Central

    Hinderdael, Michaël; Strantza, Maria; De Baere, Dieter; Devesse, Wim; De Graeve, Iris; Terryn, Herman; Guillaume, Patrick

    2017-01-01

    Additive manufacturing (AM) of metals offers new possibilities for the production of complex structures. Up to now, investigations on the mechanical response of AM metallic parts show a significant spread and unexpected failures cannot be excluded. In this work, we focus on the detection of fatigue cracks through the integration of a Structural Health Monitoring (SHM) system in Ti-6Al-4V specimens. The working principle of the presented system is based on the integration of small capillaries that are capable of detecting fatigue cracks. Four-point bending fatigue tests have been performed on Ti-6Al-4V specimens with integrated capillaries and compared to the reference specimenswithout capillaries. Specimens were produced by conventional subtractive manufacturing of wrought material and AM, using the laser based Directed Energy Deposition (DED) process. In this study, we investigated the effect of the presence of the capillary on the fatigue strength and fatigue initiation location. Finite element (FEM) simulations were performed to validate the experimental test results. The presence of a drilled capillary in the specimens did not alter the fatigue initiation location. However, the laser based DED production process introduced roughness on the capillary surface that altered the fatigue initiation location to the capillary surface. The fatigue performance was greatly reduced when considering a printed capillary. It is concluded that the surface quality of the integrated capillary is of primary importance in order not to influence the structural integrity of the component to be monitored. PMID:28841186

  19. Fatigue Performance of Ti-6Al-4V Additively Manufactured Specimens with Integrated Capillaries of an Embedded Structural Health Monitoring System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hinderdael, Michaël; Strantza, Maria; De Baere, Dieter

    Additive manufacturing (AM) of metals offers new possibilities for the production of complex structures. Up to now, investigations on the mechanical response of AM metallic parts show a significant spread and unexpected failures cannot be excluded. In this work, we focus on the detection of fatigue cracks through the integration of a Structural Health Monitoring (SHM) system in Ti-6Al-4V specimens. The working principle of the presented system is based on the integration of small capillaries that are capable of detecting fatigue cracks. Four-point bending fatigue tests have been performed on Ti-6Al-4V specimens with integrated capillaries and compared to the referencemore » specimenswithout capillaries. Specimens were produced by conventional subtractive manufacturing of wrought material and AM, using the laser based Directed Energy Deposition (DED) process. In this study, we investigated the effect of the presence of the capillary on the fatigue strength and fatigue initiation location. Finite element (FEM) simulations were performed to validate the experimental test results. The presence of a drilled capillary in the specimens did not alter the fatigue initiation location. However, the laser based DED production process introduced roughness on the capillary surface that altered the fatigue initiation location to the capillary surface. The fatigue performance was greatly reduced when considering a printed capillary. It is concluded that the surface quality of the integrated capillary is of primary importance in order not to influence the structural integrity of the component to be monitored.« less

  20. Fatigue Performance of Ti-6Al-4V Additively Manufactured Specimens with Integrated Capillaries of an Embedded Structural Health Monitoring System

    DOE PAGES

    Hinderdael, Michaël; Strantza, Maria; De Baere, Dieter; ...

    2017-08-25

    Additive manufacturing (AM) of metals offers new possibilities for the production of complex structures. Up to now, investigations on the mechanical response of AM metallic parts show a significant spread and unexpected failures cannot be excluded. In this work, we focus on the detection of fatigue cracks through the integration of a Structural Health Monitoring (SHM) system in Ti-6Al-4V specimens. The working principle of the presented system is based on the integration of small capillaries that are capable of detecting fatigue cracks. Four-point bending fatigue tests have been performed on Ti-6Al-4V specimens with integrated capillaries and compared to the referencemore » specimenswithout capillaries. Specimens were produced by conventional subtractive manufacturing of wrought material and AM, using the laser based Directed Energy Deposition (DED) process. In this study, we investigated the effect of the presence of the capillary on the fatigue strength and fatigue initiation location. Finite element (FEM) simulations were performed to validate the experimental test results. The presence of a drilled capillary in the specimens did not alter the fatigue initiation location. However, the laser based DED production process introduced roughness on the capillary surface that altered the fatigue initiation location to the capillary surface. The fatigue performance was greatly reduced when considering a printed capillary. It is concluded that the surface quality of the integrated capillary is of primary importance in order not to influence the structural integrity of the component to be monitored.« less

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