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Sample records for based ui design

  1. The Academic English Language Needs of Industrial Design Students in UiTM Kedah, Malaysia

    ERIC Educational Resources Information Center

    Adzmi, Nor Aslah; Bidin, Samsiah; Ibrahim, Syazliyati; Jusoff, Kamaruzaman

    2009-01-01

    The purpose of this study was to analyse the academic English language lacks and needs of Industrial Design students in Universiti Teknologi MARA Kedah (UiTM). It highlights the lacks and needs for English for Academic Purposes in helping the students to succeed in the program through the usage of English language. The research tools used were in…

  2. Rational Design of S-UiO-66@GO Hybrid Nanosheets for Proton Exchange Membranes with Significantly Enhanced Transport Performance.

    PubMed

    Sun, Huazhen; Tang, Beibei; Wu, Peiyi

    2017-08-09

    Metal-organic frameworks (MOFs) are being intensively explored as filler materials for polymeric proton exchange membranes (PEMs) due to their potentials for the systematic design and modification of proton-conducting properties. S-UiO-66, a stable MOF with functional groups of -SO3H in its ligands, was selected here to prepare S-UiO-66@graphene oxide (GO) hybrid nanosheets via a facile in situ growth procedure, and then a series of composite PEMs were prepared by hybridizing S-UiO-66@GO and sulfonated poly(ether ether ketone) (SPEEK). The resultant hybrid nanosheets not only possessed abundant -SO3H groups derived from the ligands of S-UiO-66 but also yielded a uniform dispersion of S-UiO-66 onto GO nanosheets, thus effectively eliminating the agglomeration of S-UiO-66 in the membrane matrix. Thanks to the well-tailored chemical composition and nanostructure of S-UiO-66@GO, the as-prepared SPEEK/S-UiO-66@GO composite PEMs present a significant increase in their proton conductivity under various conditions. In particular, the proton conductivity of the SPEEK/S-UiO-66@GO-10 membrane was up to 0.268 S·cm(-1) and 16.57 mS·cm(-1) at 70 °C-95% RH and 100 °C-40% RH (2.6 and 6.0 times that of recast SPEEK under the same condition), respectively. Moreover, the mechanical property of composite membranes was substantially strengthened and the methanol penetration was well-suppressed. Our investigation indicates the great potential of S-UiO-66@GO in fabricating composite PEMs and also reveals that the high proton conductivity of MOFs can be fully utilized by means of MOF/polymer composite membranes.

  3. Design and Fabrication of Nereid-UI: A Remotely Operated Underwater Vehicle for Oceanographic Access Under Ice

    NASA Astrophysics Data System (ADS)

    Whitcomb, L. L.; Bowen, A. D.; Yoerger, D.; German, C. R.; Kinsey, J. C.; Mayer, L. A.; Jakuba, M. V.; Gomez-Ibanez, D.; Taylor, C. L.; Machado, C.; Howland, J. C.; Kaiser, C. L.; Heintz, M.; Pontbriand, C.; Suman, S.; O'hara, L.

    2013-12-01

    -to-end propulsive efficiency of between 0.3 and 0.4 at a transit speed of 1 m/s based on testing conducted at WHOI. CAMERAS: Video imagery is one of the principal products of Nereid-UI. Two fiber-optic telemetry wavelengths deliver 1.5 Gb/s uncompressed HDSDI video to the support vessel in real time, supporting a Kongsberg OE14-522 hyperspherical pan and tilt HD camera and several utility cameras. PROJECT STATUS: The first shallow-water vehicle trials are scheduled for September 2013. The trials are designed to test core vehicle systems particularly the power system, main computer and control system, thrusters, video and telemetry system, and to refine camera, lighting and acoustic sensor placement for piloted and closed-loop control, especially as pertains to working near the underside of ice. Remaining vehicle design tasks include finalizing the single-body deployment concept and depressor, populating the scientific sensing suite, and the software development necessary to implement the planned autonomous return strategy. Final design and fabrication for these remaining components of the vehicle system will proceed through fall 2013, with trials under lake ice in early 2014, and potential polar trials beginning in 2014-15. SUPPORT: NSF OPP (ANT-1126311), WHOI, James Family Foundation, and George Frederick Jewett Foundation East.

  4. Bifunctional Imidazolium-Based Ionic Liquid Decorated UiO-67 Type MOF for Selective CO2 Adsorption and Catalytic Property for CO2 Cycloaddition with Epoxides.

    PubMed

    Ding, Luo-Gang; Yao, Bing-Jian; Jiang, Wei-Ling; Li, Jiang-Tao; Fu, Qi-Juan; Li, Yan-An; Liu, Zhen-Hua; Ma, Jian-Ping; Dong, Yu-Bin

    2017-02-20

    A bifunctional robust and highly porous imidazolium-based ionic liquid decorated UiO-67 type MOF (UiO-67-IL, 1) was successfully constructed via solvothermal assembly of the imidazolium-based ligand and Zr(IV) ions. It exhibits a highly selective adsorption for CO2 over CH4 and N2. Furthermore, 1 herein can be used as a highly active heterogeneous catalyst for CO2 cycloaddition with epoxides under atmospheric pressure with or without cocatalyst TBAB (n-Bu4NBr).

  5. Structural study of Ni- or Mg-based complexes incorporated within UiO-66-NH{sub 2} framework and their impact on hydrogen sorption properties

    SciTech Connect

    Žunkovič, E.; Mazaj, M.; Mali, G.; Rangus, M.; Devic, T.; Serre, C.; Logar, N. Zabukovec

    2015-05-15

    Nickel and magnesium acetylacetonate molecular complexes were post-synthetically incorporated into microporous zirconium-based MOF (UiO-66-NH{sub 2}) in order to introduce active open-metal sites for hydrogen sorption. Elemental analysis, nitrogen physisorption and DFT calculations revealed that 5 molecules of Ni(acac){sub 2} or 2 molecules of Mg(acac){sub 2} were incorporated into one unit cell of UiO-66-NH{sub 2}. {sup 1}H–{sup 13}C CPMAS and {sup 1}H MAS NMR spectroscopy showed that, although embedded within the pores, both Ni- and Mg-complexes interacted with the UiO-66-NH{sub 2} framework only through weak van der Waals bonds. Inclusion of metal complexes led to the decrease of hydrogen sorption capacities in Ni-modified as well as in Mg-modified samples in comparison with the parent UiO-66-NH{sub 2}. The isosteric hydrogen adsorption enthalpy slightly increased in the case of Ni-modified material, but not in the case of Mg-modified analogue. - Graphical abstract: A post-synthesis impregnation of Mg- and Ni-acetylacetonate complexes performed on zirconium-based MOF UiO-66-NH{sub 2} does influence the hydrogen sorption performance with respect to the parent matrix. The structural study revealed that Mg- and Ni-acetylacetonate molecules interact with zirconium-terephthalate framework only by weak interactions and they are not covalently bonded to aminoterephthalate ligand. Still, they remain confined into the pores even after hydrogen sorption experiments. - Highlights: • Mg- and Ni-acetylacetonate molecules embedded in the pores of UiO-66-NH{sub 2} by PSM. • Molecules of complexes interact with framework only by van der Waals interactions. • Type/structure of deposited metal-complex impact hydrogen enthalpy of adsorption.

  6. m-YouTube Mobile UI: Video Selection Based on Social Influence

    NASA Astrophysics Data System (ADS)

    Marcus, Aaron; Perez, Angel

    The ease-of-use of Web-based video-publishing services provided by applications like YouTube has encouraged a new means of asynchronous communication, in which users can post videos not only to make them public for review and criticism, but also as a way to express moods, feelings, or intentions to an ever-growing network of friends. Following the current trend of porting Web applications onto mobile platforms, the authors sought to explore user-interface design issues of a mobile-device-based YouTube, which they call m-YouTube. They first analyzed the elements of success of the current YouTube Web site and observed its functionality. Then, they looked for unsolved issues that could give benefit through information-visualization design for small screens on mobile phones to explore a mobile version of such a product/service. The biggest challenge was to reduce the number of functions and amount information to fit into a mobile phone screen, but still be usable, useful, and appealing within the YouTube context of use and user experience. Borrowing ideas from social research in the area of social influence processes, they made design decisions aiming to help YouTube users to make the decision of what video content to watch and to increase the chances of YouTube authors being evaluated and observed by peers. The paper proposes a means to visualize large amounts of video relevant to YouTube users by using their friendship network as a relevance indicator to help in the decision-making process.

  7. Megamodeling and Metamodel-Driven Engineering for Plastic User Interfaces: MEGA-UI

    NASA Astrophysics Data System (ADS)

    Sottet, Jean-Sébastien; Calvary, Gaelle; Favre, Jean-Marie; Coutaz, Jöelle

    Models are not new in Human Computer Interaction (HCI). Consider all the Model-Based Interface Design Environments (MB-IDE) that emerged in the 1990s for generating User Interfaces (UI) from more abstract descriptions. Unfortunately, the resulting poor usability killed the approach, burying the models in HCI for a long time until new requirements sprung, pushed by ubiquitous computing (e.g., the need for device independence). These requirements, bolstered by the large effort expended in Model-Driven Engineering (MDE) by the Software Engineering (SE) community, have brought the models back to life in HCI. This paper utilizes both the know-how in HCI and recent advances in MDE to address the challenge of engineering Plastic UIs, i.e., UIs capable of adapting to their context of use (User, Platform, Environment) while preserving usability. Although most of the work has concentrated on the functional aspect of adaptation so far, this chapter focuses on usability. The point is to acknowledge the strength of keeping trace of the UI’s design rationale at runtime so as to make it possible for the system to reason about its own design when the context of use changes. As design transformations link together different perspectives on the same UI (e.g., user’s tasks and workspaces for spatially grouping items together), the paper claims for embedding a graph that depicts a UI from different perspectives at runtime while explaining its design rationale. This meets the notion of Megamodel as promoted in MDE. The first Megamodel was used to make explicit the relations between the core concepts of MDE: System, Model, Metamodel, Mapping, and Transformation. When transposed to HCI, the Megamodel gives rise to the notion of Mega-UI that makes it possible for the user (designer and/or end-user) to browse and/or control the system from different levels of abstraction (e.g., user’s tasks, workspaces, interactors, code) and different levels of genericity (e.g., model, metamodel

  8. Structural study of Ni- or Mg-based complexes incorporated within UiO-66-NH2 framework and their impact on hydrogen sorption properties

    NASA Astrophysics Data System (ADS)

    Žunkovič, E.; Mazaj, M.; Mali, G.; Rangus, M.; Devic, T.; Serre, C.; Logar, N. Zabukovec

    2015-05-01

    Nickel and magnesium acetylacetonate molecular complexes were post-synthetically incorporated into microporous zirconium-based MOF (UiO-66-NH2) in order to introduce active open-metal sites for hydrogen sorption. Elemental analysis, nitrogen physisorption and DFT calculations revealed that 5 molecules of Ni(acac)2 or 2 molecules of Mg(acac)2 were incorporated into one unit cell of UiO-66-NH2. 1H-13C CPMAS and 1H MAS NMR spectroscopy showed that, although embedded within the pores, both Ni- and Mg-complexes interacted with the UiO-66-NH2 framework only through weak van der Waals bonds. Inclusion of metal complexes led to the decrease of hydrogen sorption capacities in Ni-modified as well as in Mg-modified samples in comparison with the parent UiO-66-NH2. The isosteric hydrogen adsorption enthalpy slightly increased in the case of Ni-modified material, but not in the case of Mg-modified analogue.

  9. Effective adsorption and enhanced removal of organophosphorus pesticides from aqueous solution by Zr-based MOFs of UiO-67.

    PubMed

    Zhu, Xiangyang; Li, Bing; Yang, Jian; Li, Yongsheng; Zhao, Wenru; Shi, Jianlin; Gu, Jinlou

    2015-01-14

    Though many efforts have been devoted to the adsorptive removal of hazardous materials of organophosphorus pesticides (OPs), it is still highly desirable to develop novel adsorbents with high adsorption capacities. In the current work, the removal of two representative OPs, glyphosate (GP) and glufosinate (GF), was investigated by the exceptionally stable Zr-based MOFs of UiO-67. The abundant Zr-OH groups, resulting from the missing-linker induced terminal hydroxyl groups and the inherent bridging ones in Zr-O clusters of UiO-67 particles, served as natural anchorages for efficient GP and GF capture in relation with their high affinity toward phosphoric groups in OPs. The correlation between the most significant parameters such as contact time, OPs concentration, adsorbent dose, pH, as well as ionic strength with the adsorption capacities was optimized, and the effects of these parameters on the removal efficiency of GP and GF from the polluted aqueous solution were investigated. The adsorption of GP on UiO-67 was faster than that of GF, and a pseudo-second-order rate equation effectively described the uptake kinetics. The Langmuir model exhibited a better fit to adsorption isotherm than the Freundlich model. Thanks to the strong affinity and adequate pore size, the adsorption capacities in UiO-67 approached as high as 3.18 mmol (537 mg) g(-1) for GP and 1.98 mmol (360 mg) g(-1) for GF, which were much higher than those of many other reported adsorbents. The excellent adsorption characteristics of the current adsorbents toward OPs were preserved in a wide pH window and high concentration of the background electrolytes. These prefigured the promising potentials of UiO-67 as novel adsorbent for the efficient removal of OPs from aqueous solution.

  10. Selective dispersive solid phase extraction-chromatography tandem mass spectrometry based on aptamer-functionalized UiO-66-NH2 for determination of polychlorinated biphenyls.

    PubMed

    Lin, Saichai; Gan, Ning; Cao, Yuting; Chen, Yinji; Jiang, Qianli

    2016-05-13

    In this paper, a novel dispersive solid phase extraction (dSPE) adsorbent based on aptamer-functionalized magnetic metal-organic framework material was developed for selective enrichment of the trace polychlorinated biphenyls (PCBs) from soil sample. Firstly, we developed a simple, versatile synthetic strategy to prepare highly reproducible magnetic amino-functionalized UiO-66 (Fe3O4@PDA@UiO-66-NH2) by using polydopamine (PDA) as covalent linker. Then amino-functionalized aptamers which can recognize 2,3',5,5'-tetrachlorobiphenyl (PCB72), 2',3',4',5,5'-pentachlorobiphenyl (PCB106) were covalent immobilized on UiO-66-NH2 through coupling reagent of glutaraldehyde. Aptamer-functionalized adsorbent (Fe3O4@PDA@UiO-66-Apt) can specifically capture PCBs from complex matrix with high adsorption capacity based on the specific affinity of aptamer towards target. Moreover, the adsorbent can be easily isolated from the solution through magnetic separation after extraction. Afterwards, the detection was carried out with gas chromatography tandem mass spectrometry (GC-MS). The selective dSPE pretreatment coupled with GC-MS possessed high selectivity, good binding capacity, stability, repeatability and reproducibility for the extraction of PCBs. Furthermore, the adsorbent possessed good mechanical stability which can be applied in replicate at least for 60 extraction cycles with recovery over 80%. It provided a linear range of 0.02-400ngmL(-1) with a good correlation coefficient (R(2)=0.9994-0.9996), and the limit of detection was found to be 0.010-0.015ngmL(-1). The method was successfully utilized for the determination of PCBs in soil samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  11. Metal-Organic Gel Material Based on UiO-66-NH2 Nanoparticles for Improved Adsorption and Conversion of Carbon Dioxide.

    PubMed

    Liu, Liping; Zhang, Jianyong; Fang, Haobin; Chen, Liuping; Su, Cheng-Yong

    2016-08-19

    Metal-organic frameworks (MOFs) including the UiO-66 series show potential application in the adsorption and conversion of CO2 . Herein, we report the first tetravalent metal-based metal-organic gels constructed from Zr(IV) and 2-aminoterephthalic acid (H2 BDC-NH2 ). The ZrBDC-NH2 gel materials are based on UiO-66-NH2 nanoparticles and were easily prepared under mild conditions (80 °C for 4.5 h). The ZrBDC-NH2 -1:1-0.2 gel material has a high surface area (up to 1040 m(2)  g(-1) ) and showed outstanding performance in CO2 adsorption (by using the dried material) and conversion (by using the wet gel) arising from the combined advantages of the gel and the UiO-66-NH2 MOF. The ZrBDC-NH2 -1:1-0.2 dried material showed 38 % higher capture capacity for CO2 at 298 K than microcrystalline UiO-66-NH2 . It showed high ideal adsorbed solution theory selectivity (71.6 at 298 K) for a CO2 /N2 gas mixture (molar ratio 15:85). Furthermore, the ZrBDC-NH2 -1:1-0.2 gel showed activity as a heterogeneous catalyst in the chemical fixation of CO2 and an excellent catalytic performance was achieved for the cycloaddition of atmospheric pressure of CO2 to epoxides at 373 K. In addition, the gel catalyst could be reused over multiple cycles with no considerable loss of catalytic activity. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. The role of autophagy in cytotoxicity induced by new oncogenic B-Raf inhibitor UI-152 in v-Ha-ras transformed fibroblasts

    SciTech Connect

    Ahn, Jun-Ho; Ahn, Soon Kil; Lee, Michael

    2012-01-13

    Highlights: Black-Right-Pointing-Pointer We recently discovered a potent and selective B-Raf inhibitor, UI-152. Black-Right-Pointing-Pointer UI-152 displayed a selective cytotoxicity toward v-Ha-ras transformed cells. Black-Right-Pointing-Pointer UI-152-induced growth inhibition was largely meditated by autophagy. Black-Right-Pointing-Pointer UI-152 induced paradoxical activation of Raf-1. -- Abstract: In human cancers, B-Raf is the most frequently mutated protein kinase in the MAPK signaling cascade, making it an important therapeutic target. We recently discovered a potent and selective B-Raf inhibitor, UI-152, by using a structure-based drug design strategy. In this study, we examined whether B-Raf inhibition by UI-152 may be an effective therapeutic strategy for eliminating cancer cells transformed with v-Ha-ras (Ras-NIH 3T3). UI-152 displayed selective cytotoxicity toward Ras-NIH 3T3 cells while having little to no effect on non-transformed NIH 3T3 cells. We found that treatment with UI-152 markedly increased autophagy and, to a lesser extent, apoptosis. However, inhibition of autophagy by addition of 3-MA failed to reverse the cytotoxic effects of UI-152 on Ras-NIH 3T3 cells, demonstrating that apoptosis and autophagy can act as cooperative partners to induce growth inhibition in Ras-NIH 3T3 cells treated with UI-152. Most interestingly, cell responses to UI-152 appear to be paradoxical. Here, we showed that although UI-152 inhibited ERK, it induced B-Raf binding to Raf-1 as well as Raf-1 activation. This paradoxical activation of Raf-1 by UI-152 is likely to be coupled with the inhibition of the mTOR pathway, an intracellular signaling pathway involved in autophagy. We also showed for the first time that, in multi-drug resistant cells, the combination of UI-152 with verapamil significantly decreased cell proliferation and increased autophagy. Thus, our findings suggest that the inhibition of autophagy, in combination with UI-152, offers a more effective

  13. Benzimidazole-functionalized Zr-UiO-66 nanocrystals for luminescent sensing of Fe3+ in water

    NASA Astrophysics Data System (ADS)

    Dong, Yingying; Zhang, Hanzhuo; Lei, Fan; Liang, Mei; Qian, Xuefeng; Shen, Peilian; Xu, Hui; Chen, Zhihui; Gao, Junkuo; Yao, Juming

    2017-01-01

    Zr-based MOF structure UiO-66 exhibits unprecedented high thermal and chemical stability, making it to be one of the most used MOFs in various applications. Yet, the poor photoluminescent (PL) properties of UiO-66 limit its applications in luminescent sensing. Herein, a new benzimidazole-functionalized UiO-66 nanocrystal (UiO-66-BI) was successfully fabricated via microwave synthesis. UiO-66-BI displayed octahedral nanocrystal morphology with a diameter smaller than 200 nm and could disperse well in water and common organic solvents. UiO-66-BI demonstrated extended optical absorption in the visible-light region and efficiently improved PL emission compared with UiO-66 pristine. The sensing properties of UiO-66-BI nanocrystals towards different ions were studied, and the results demonstrated that UiO-66-BI showed excellent selective luminescent sensing of Fe3+ ions in water.

  14. Missing Linkers: An Alternative Pathway to UiO-66 Electronic Structure Engineering

    PubMed Central

    2017-01-01

    UiO-66 is a promising metal–organic framework for photocatalytic applications. However, the ligand-to-metal charge transfer of an excited electron is inefficient in the pristine material. Herein, we assess the influence of missing linker defects on the electronic structure of UiO-66 and discuss their ability to improve ligand-to-metal charge transfer. Using a new defect classification system, which is transparent and easily extendable, we identify the most promising photocatalysts by considering both relative stability and electronic structure. We find that the properties of UiO-66 defect structures largely depend on the coordination of the constituent nodes and that the nodes with the strongest local distortions alter the electronic structure most. Defects hence provide an alternative pathway to tune UiO-66 for photocatalytic purposes, besides linker modification and node metal substitution. In addition, the decomposition of MOF properties into node- and linker-based behavior is more generally valid, so we propose orthogonal electronic structure tuning as a paradigm in MOF design. PMID:28413260

  15. H2 storage in isostructural UiO-67 and UiO-66 MOFs.

    PubMed

    Chavan, Sachin; Vitillo, Jenny G; Gianolio, Diego; Zavorotynska, Olena; Civalleri, Bartolomeo; Jakobsen, Søren; Nilsen, Merete H; Valenzano, Loredana; Lamberti, Carlo; Lillerud, Karl Petter; Bordiga, Silvia

    2012-02-07

    The recently discovered UiO-66/67/68 class of isostructural metallorganic frameworks (MOFs) [J. H. Cavka et al. J. Am. Chem. Soc., 2008, 130, 13850] has attracted great interest because of its remarkable stability at high temperatures, high pressures and in the presence of different solvents, acids and bases [L. Valenzano et al. Chem. Mater., 2011, 23, 1700]. UiO-66 is obtained by connecting Zr(6)O(4)(OH)(4) inorganic cornerstones with 1,4-benzene-dicarboxylate (BDC) as linker resulting in a cubic MOF, which has already been successfully reproduced in several laboratories. Here we report the first complete structural, vibrational and electronic characterization of the isostructural UiO-67 material, obtained using the longer 4,4'-biphenyl-dicarboxylate (BPDC) linker, by combining laboratory XRPD, Zr K-edge EXAFS, TGA, FTIR, and UV-Vis studies. Comparison between experimental and periodic calculations performed at the B3LYP level of theory allows a full understanding of the structural, vibrational and electronic properties of the material. Both materials have been tested for molecular hydrogen storage at high pressures and at liquid nitrogen temperature. In this regard, the use of a longer ligand has a double benefit: (i) it reduces the density of the material and (ii) it increases the Langmuir surface area from 1281 to 2483 m(2) g(-1) and the micropore volume from 0.43 to 0.85 cm(3) g(-1). As a consequence, the H(2) uptake at 38 bar and 77 K increases from 2.4 mass% for UiO-66 up to 4.6 mass% for the new UiO-67 material. This value is among the highest values reported so far but is lower than those reported for MIL-101, IRMOF-20 and MOF-177 under similar pressure and temperature conditions (6.1, 6.2 and 7.0 mass%, respectively) [A. G. Wong-Foy et al. J. Am. Chem. Soc., 2006, 128, 3494; M. Dinca and J. R. Long. Angew. Chem., Int. Ed., 2008, 47, 6766]. Nevertheless the remarkable chemical and thermal stability of UiO-67 and the absence of Cr in its structure would

  16. Highly dispersed palladium nanoparticles anchored on UiO-66(NH2) metal-organic framework as a reusable and dual functional visible-light-driven photocatalyst

    NASA Astrophysics Data System (ADS)

    Shen, Lijuan; Wu, Weiming; Liang, Ruowen; Lin, Rui; Wu, Ling

    2013-09-01

    Proper design and preparation of high-performance and stable dual functional photocatalytic materials remains a significant objective of research. In this work, highly dispersed Pd nanoparticles of about 3-6 nm in diameter are immobilized in the metal-organic framework (MOF) UiO-66(NH2) via a facile one-pot hydrothermal method. The resulting Pd@UiO-66(NH2) nanocomposite exhibits an excellent reusable and higher visible light photocatalytic activity for reducing Cr(vi) compared with UiO-66(NH2) owing to the high dispersion of Pd nanoparticles and their close contact with the matrix, which lead to the enhanced light harvesting and more efficient separation of photogenerated electron-hole pairs. More significantly, the Pd@UiO-66(NH2) could be used for simultaneous photocatalytic degradation of organic pollutants, like methyl orange (MO) and methylene blue (MB), and reduction of Cr(vi) with even further enhanced activity in the binary system, which could be attributed to the synergetic effect between photocatalytic oxidation and reduction by individually consuming photogenerated holes and electrons. This work represents the first example of using the MOFs-based materials as dual functional photocatalyst to remove different categories of pollutants simultaneously. Our finding not only proves great potential for the design and application of MOFs-based materials but also might bring light to new opportunities in the development of new high-performance photocatalysts.Proper design and preparation of high-performance and stable dual functional photocatalytic materials remains a significant objective of research. In this work, highly dispersed Pd nanoparticles of about 3-6 nm in diameter are immobilized in the metal-organic framework (MOF) UiO-66(NH2) via a facile one-pot hydrothermal method. The resulting Pd@UiO-66(NH2) nanocomposite exhibits an excellent reusable and higher visible light photocatalytic activity for reducing Cr(vi) compared with UiO-66(NH2) owing to the

  17. Tuning the stability of bimetallic Ce(iv)/Zr(iv)-based MOFs with UiO-66 and MOF-808 structures.

    PubMed

    Lammert, M; Glißmann, C; Stock, N

    2017-02-21

    A series of solid solutions of bimetallic Ce/Zr-UiO-66 and -MOF-808 compounds with a varying ratio of Ce(4+) to Zr(4+) were obtained under mild reaction conditions within 15 min. The lattice parameters of the mixed-metal compounds are in accordance with Vegard's law. Samples with Ce ≤20 at% exhibit an enhanced thermal stability, better resistance against acids and smaller particle sizes.

  18. Registration of ‘UI Darwin’ Wheat

    USDA-ARS?s Scientific Manuscript database

    UI Darwin’ (PI 639953) is a hard white winter wheat (Triticum aestivum L.) developed by the Idaho Agricultural Experiment Station and released in February 2006. UI Darwin, named for English naturalist Charles Darwin, was released for selected improvements in bread quality relative to hard white wi...

  19. 75 FR 43557 - Wire Products Company, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Paid...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-26

    ... Employment and Training Administration Wire Products Company, Inc., Including Workers Whose Unemployment... unemployment insurance (UI) tax account under the name Globe Pipe Hanger Products, Inc. Based on these findings..., Inc., including workers whose unemployment insurance (UI) wages are paid through Globe Pipe Hanger...

  20. Use of Design Patterns According to Hand Dominance in a Mobile User Interface

    ERIC Educational Resources Information Center

    Al-Samarraie, Hosam; Ahmad, Yusof

    2016-01-01

    User interface (UI) design patterns for mobile applications provide a solution to design problems and can improve the usage experience for users. However, there is a lack of research categorizing the uses of design patterns according to users' hand dominance in a learning-based mobile UI. We classified the main design patterns for mobile…

  1. Use of Design Patterns According to Hand Dominance in a Mobile User Interface

    ERIC Educational Resources Information Center

    Al-Samarraie, Hosam; Ahmad, Yusof

    2016-01-01

    User interface (UI) design patterns for mobile applications provide a solution to design problems and can improve the usage experience for users. However, there is a lack of research categorizing the uses of design patterns according to users' hand dominance in a learning-based mobile UI. We classified the main design patterns for mobile…

  2. Adsorption of fluoride to UiO-66-NH2 in water: Stability, kinetic, isotherm and thermodynamic studies.

    PubMed

    Lin, Kun-Yi Andrew; Liu, Yu-Ting; Chen, Shen-Yi

    2016-01-01

    To provide safe drinking water, fluoride in water must be removed and adsorption processes appear to be the most widely used method. Metal organic frameworks (MOFs) represent a new class of adsorbents that have been used in various adsorption applications. To study the adsorption mechanism of fluoride to MOFs in water and obtain related adsorption parameters, we synthesized a zirconium-based MOF with a primary amine group on its ligand, named UiO-66-NH2. The kinetics, adsorption isotherm and thermodynamics of fluoride adsorption to UiO-66-NH2 were investigated. The crystalline structure of UiO-66-NH2 remained intact and the local structure of zirconium in UiO-66-NH2 did not change significantly after being exposed to fluoride. The kinetics of the fluoride adsorption in UiO-66-NH2 could be well represented by the pseudo second order rate law. The enthalpy of the adsorption indicates that the F(-) adsorption to UiO-66-NH2 was classified as a physical adsorption. However, the comparison between the adsorption capacities of UiO-66-NH2 and UiO-66 suggests that the fluoride adsorption to UiO-66-NH2 might primarily involve a strong interaction between F(-) and the metal site. The fluoride adsorption capacity of UiO-66-NH2 was found to decrease when pH>7. While the presence of chloride/bromide ions did not noticeably change the adsorption capacity of UiO-66-NH2, the ionic surfactants slightly affected the adsorption capacity of UiO-66-NH2. These findings provide insights to further optimize the adsorption process for removal of fluoride using zirconium-based MOFs.

  3. Study of the Inorganic Substitution in a Functionalized UiO-66 Metal-Organic Framework

    NASA Astrophysics Data System (ADS)

    Yasin, Alhassan Salman

    Metal-Organic Frameworks (MOFs) have received considerable attention and fast development in the past few years. These materials have demonstrated a wide range of applications due to their porosity, tailorability of optical properties, and chemical selectivity. This report catalogs common MOF designs based on application and diversity in various fields, as well as conduct an in-depth study of inorganic substitution in a functionalized MOF. This study investigates the band gap modulation in response to inorganic ion substitution within a thermally stable UiO-66 Metal-Organic Framework (MOF). A combination of density functional theory (DFT) predictions in conjunction with experimental predictions were used to map out the complete composition space for three inorganic ions (Zr, Hf, Ti) and three functional groups. The three functional groups include an amino group (NH2), a nitro group (NO2), and a hydrogenated case (H). The smallest determined band gap was for a partially substituted UiO-66(Ti5Zr1)-NH2 resulting in 2.60eV. Theoretical findings sup-port that Ti can be fully substituted within the lattice resulting in a predicted band gap as low as 1.62(2.77)eV. Band gap modulation was reasoned to be a result of a mid gap state introduced through the amino functionalization and HOMO shifting as a result of increased binding of the Ti-O-C bonds.

  4. High-, Middle-, and Low-Wage Job Preparatory Programs--The Creation and Use of Policy Tool Based on UI Wages Data. Technical Report.

    ERIC Educational Resources Information Center

    Whittaker, Doug

    This is a report on the 2001 after-college earnings of students from Washington State's community and technical colleges. The state board created a wage-based category system for all 500 vocational/job-preparatory programs offered by the 34 state two-year colleges. The programs were divided into high- ($12 or more per hour), middle- ($10.50-$12…

  5. Exploiting parameter space in MOFs: a 20-fold enhancement of phosphate-ester hydrolysis with UiO-66-NH 2

    SciTech Connect

    Katz, Michael J.; Moon, Su-Young; Mondloch, Joseph E.; Beyzavi, M. Hassan; Stephenson, Casey J.; Hupp, Joseph T.; Farha, Omar K.

    2015-02-24

    The hydrolysis of nerve agents is of primary concern due to the severe toxicity of these agents. Using a MOF-based catalyst (UiO-66), we have previously demonstrated that the hydrolysis can occur with relatively fast half-lives of 50 minutes. However, these rates are still prohibitively slow to be efficiently utilized for some practical applications (e.g., decontamination wipes used to clean exposed clothing/skin/vehicles). We thus turned our attention to derivatives of UiO-66 in order to probe the importance of functional groups on the hydrolysis rate. Three UiO-66 derivatives were explored; UiO-66-NO2 and UiO-66-(OH)2 showed little to no change in hydrolysis rate. However, UiO-66-NH2 showed a 20 fold increase in hydrolysis rate over the parent UiO-66 MOF. Half-lives of 1 minute were observed with this MOF. In order to probe the role of the amino moiety, we turned our attention to UiO-67, UiO-67-NMe2 and UiO-67-NH2. In these MOFs, the amino moiety is in close proximity to the zirconium node. We observed that UiO-67-NH2 is a faster catalyst than UiO-67 and UiO-67-NMe2. We conclude that the role of the amino moiety is to act as a proton-transfer agent during the catalytic cycle and not to hydrogen bond or to form a phosphorane intermediate.

  6. Exploiting parameter space in MOFs: a 20-fold enhancement of phosphate-ester hydrolysis with UiO-66-NH 2

    DOE PAGES

    Katz, Michael J.; Moon, Su-Young; Mondloch, Joseph E.; ...

    2015-02-24

    The hydrolysis of nerve agents is of primary concern due to the severe toxicity of these agents. Using a MOF-based catalyst (UiO-66), we have previously demonstrated that the hydrolysis can occur with relatively fast half-lives of 50 minutes. However, these rates are still prohibitively slow to be efficiently utilized for some practical applications (e.g., decontamination wipes used to clean exposed clothing/skin/vehicles). We thus turned our attention to derivatives of UiO-66 in order to probe the importance of functional groups on the hydrolysis rate. Three UiO-66 derivatives were explored; UiO-66-NO2 and UiO-66-(OH)2 showed little to no change in hydrolysis rate. However,more » UiO-66-NH2 showed a 20 fold increase in hydrolysis rate over the parent UiO-66 MOF. Half-lives of 1 minute were observed with this MOF. In order to probe the role of the amino moiety, we turned our attention to UiO-67, UiO-67-NMe2 and UiO-67-NH2. In these MOFs, the amino moiety is in close proximity to the zirconium node. We observed that UiO-67-NH2 is a faster catalyst than UiO-67 and UiO-67-NMe2. We conclude that the role of the amino moiety is to act as a proton-transfer agent during the catalytic cycle and not to hydrogen bond or to form a phosphorane intermediate.« less

  7. Probabalistic projections for recovery of the endangered Cui-ui

    USGS Publications Warehouse

    Emlen, John M.; Strekal, Thomas A.; Buchanan , Chester C.

    1993-01-01

    The cui-ui Chamistes cujus, a lake sucker found in only Pyramid Lake, Nevada, is listed as endangered under the U.S. Endangered Species Act, and a recovery plan has been formulated in an effort to save it. We used a population simulation model that incorporated environmental stochasticity in water availability to project the persistence of cui-ui over 200 years, Based on this approach, recovery of the species in terms of persistence was evaluated for the existing hydrological situation and for situations involving water supplementation in various amounts. Our calculations indicate that immediate (as of spring 1991) acquisition of 70,000 acre-feet per year of supplemental water to raise levels in Pyramid Lake would have assured recovery and persistence over 200 years with a probability of 0.95. Postponement of acquisition for 3 years followed by incremental increases of 3,000 or 10,000 acre-feet per year would require, respectively, 83,000 and 120,000 acre-feet of annual supplemental water to assure persistence. The approach is applicable to a wide range of species and conditions.

  8. Integrated Information Support System (IISS). Volume 8. User Interface Subsystem. Part 3. User Interface (UI) Services Product Specification

    DTIC Science & Technology

    1990-09-30

    APPDEF APPlication DEFinition data declarations CICODE Command Interpreter CODEs CURSORI CURSOR description DBNAME DataBase field NAMEs DEFCOM DEFCOM data...Module Module File Name Purpose DBNAME DBOPEN OPEN DATA BASE PROCDF PROCess DeFine form PROCPW PROCESS PSWORD FORM DEFCOM PROCDC PROCess Define Command...SUBSYSTEM: UI SUBDIRECTORY: UIS DOCUMENTATION GROUP: UISERV DESCRIPTION: THIS MODULE PROCESSES THE DEFCOM FORM OF THE UIMS SYSTEM SERVICES. ARGUMENTS

  9. Release of ‘UI Platinum’ hard white spring wheat

    USDA-ARS?s Scientific Manuscript database

    UI Platinum’ (Reg. No. CV------, PI 672533) hard white spring wheat (Triticum aestivum L.) was developed by the Idaho Agricultural Experiment Station and released in 2014. UI Platinum was derived from the cross ‘Blanca Grande’ x ‘Jerome’ and tested under experimental numbers A01178S, IDO694, and I...

  10. 77 FR 4368 - ArcelorMittal, Including Workers Whose Unemployment Insurance (UI) Wages Are Reported Through...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-27

    ... in production of hot and cold rolled steel. New information shows that some workers separated from...) Wages Are Reported Through Mittal Steel USA, Inc., Including On- Site Leased Workers From Adecco, ESW... unemployment insurance (UI) tax account under the name Mittal Steel USA, Inc. Based on these findings,...

  11. 78 FR 59374 - Announcement Regarding a Change in Eligibility for Unemployment Insurance (UI) Claimants in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-26

    ... Employment and Training Administration Announcement Regarding a Change in Eligibility for Unemployment Insurance (UI) Claimants in Alaska, Mississippi, and Wisconsin in the Emergency Unemployment Compensation..., 2013. Based on data from Alaska for the week ending August 3, 2013, the 13 week insured unemployment...

  12. 78 FR 68865 - Announcement Regarding a Change in Eligibility for Unemployment Insurance (UI) Claimants in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-15

    ... Employment and Training Administration Announcement Regarding a Change in Eligibility for Unemployment Insurance (UI) Claimants in Alaska, Mississippi, and Wisconsin in the Emergency Unemployment Compensation..., 2013. Based on data from Alaska for the week ending August 3, 2013, the 13 week insured unemployment...

  13. 75 FR 52981 - Bluescope Buildings North America, Including Workers Whose Unemployment Insurance (UI) Wages Are...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... Unemployment Insurance (UI) Wages Are Reported Through Butler Manufacturing Company, Laurinburg, NC; Amended...Scope Buildings North America had their wages reported through a separate unemployment insurance (UI... America, including workers whose unemployment insurance (UI) wages are reported through Butler...

  14. All-gas-phase synthesis of UiO-66 through modulated atomic layer deposition

    PubMed Central

    Lausund, Kristian Blindheim; Nilsen, Ola

    2016-01-01

    Thin films of stable metal-organic frameworks (MOFs) such as UiO-66 have enormous application potential, for instance in microelectronics. However, all-gas-phase deposition techniques are currently not available for such MOFs. We here report on thin-film deposition of the thermally and chemically stable UiO-66 in an all-gas-phase process by the aid of atomic layer deposition (ALD). Sequential reactions of ZrCl4 and 1,4-benzenedicarboxylic acid produce amorphous organic–inorganic hybrid films that are subsequently crystallized to the UiO-66 structure by treatment in acetic acid vapour. We also introduce a new approach to control the stoichiometry between metal clusters and organic linkers by modulation of the ALD growth with additional acetic acid pulses. An all-gas-phase synthesis technique for UiO-66 could enable implementations in microelectronics that are not compatible with solvothermal synthesis. Since this technique is ALD-based, it could also give enhanced thickness control and the possibility to coat irregular substrates with high aspect ratios. PMID:27876797

  15. All-gas-phase synthesis of UiO-66 through modulated atomic layer deposition

    NASA Astrophysics Data System (ADS)

    Lausund, Kristian Blindheim; Nilsen, Ola

    2016-11-01

    Thin films of stable metal-organic frameworks (MOFs) such as UiO-66 have enormous application potential, for instance in microelectronics. However, all-gas-phase deposition techniques are currently not available for such MOFs. We here report on thin-film deposition of the thermally and chemically stable UiO-66 in an all-gas-phase process by the aid of atomic layer deposition (ALD). Sequential reactions of ZrCl4 and 1,4-benzenedicarboxylic acid produce amorphous organic-inorganic hybrid films that are subsequently crystallized to the UiO-66 structure by treatment in acetic acid vapour. We also introduce a new approach to control the stoichiometry between metal clusters and organic linkers by modulation of the ALD growth with additional acetic acid pulses. An all-gas-phase synthesis technique for UiO-66 could enable implementations in microelectronics that are not compatible with solvothermal synthesis. Since this technique is ALD-based, it could also give enhanced thickness control and the possibility to coat irregular substrates with high aspect ratios.

  16. All-gas-phase synthesis of UiO-66 through modulated atomic layer deposition.

    PubMed

    Lausund, Kristian Blindheim; Nilsen, Ola

    2016-11-23

    Thin films of stable metal-organic frameworks (MOFs) such as UiO-66 have enormous application potential, for instance in microelectronics. However, all-gas-phase deposition techniques are currently not available for such MOFs. We here report on thin-film deposition of the thermally and chemically stable UiO-66 in an all-gas-phase process by the aid of atomic layer deposition (ALD). Sequential reactions of ZrCl4 and 1,4-benzenedicarboxylic acid produce amorphous organic-inorganic hybrid films that are subsequently crystallized to the UiO-66 structure by treatment in acetic acid vapour. We also introduce a new approach to control the stoichiometry between metal clusters and organic linkers by modulation of the ALD growth with additional acetic acid pulses. An all-gas-phase synthesis technique for UiO-66 could enable implementations in microelectronics that are not compatible with solvothermal synthesis. Since this technique is ALD-based, it could also give enhanced thickness control and the possibility to coat irregular substrates with high aspect ratios.

  17. Earthdata User Interface Patterns: Building Usable Web Interfaces Through a Shared UI Pattern Library

    NASA Astrophysics Data System (ADS)

    Siarto, J.

    2014-12-01

    As more Earth science software tools and services move to the web--the design and usability of those tools become ever more important. A good user interface is becoming expected and users are becoming increasingly intolerant of websites and web applications that work against them. The Earthdata UI Pattern Library attempts to give these scientists and developers the design tools they need to make usable, compelling user interfaces without the associated overhead of using a full design team. Patterns are tested and functional user interface elements targeted specifically at the Earth science community and will include web layouts, buttons, tables, typography, iconography, mapping and visualization/graphing widgets. These UI elements have emerged as the result of extensive user testing, research and software development within the NASA Earthdata team over the past year.

  18. Development of Nereid-UI: A Remotely Operated Underwater Vehicle for Oceanographic Access Under Ice

    NASA Astrophysics Data System (ADS)

    Whitcomb, L. L.; Bowen, A.; Yoerger, D. R.; German, C. R.; Kinsey, J. C.; Mayer, L. A.; Jakuba, M.; Gomez-Ibanez, D.; Taylor, C. L.; Machado, C.; Howland, J. C.; Kaiser, C. L.; Heintz, M.

    2012-12-01

    The Woods Hole Oceanographic Institution and collaborators from the Johns Hopkins University and the University of New Hampshire are developing a remotely-controlled underwater robotic vehicle to provide the Polar Research Community with a capability to be tele-operated under ice under direct real-time human supervision. The Nereid Under-Ice (Nereid-UI) vehicle, Figure 1, will enable exploration and detailed examination of biological and physical environments at glacial ice-tongues and ice-shelf margins through the use of HD video in addition to acoustic, chemical, and biological sensors, Table 1. We anticipate propulsion system optimization that will enable us to attain distances up to 20 km from an ice-edge boundary, as dictated by the current maximum tether length. The goal of the Nereid-UI system is to provide scientific access to under-ice and ice-margin environments that is presently impractical or infeasible. The project design phase is underway, with incremental field testing planned in 2014. We welcome input from the Polar Science Community on how best to serve your scientific objectives. The Nereid-UI vehicle will employ technology developed during the Nereus HROV project including lightweight expendable tethers and tolerance of communications failures. Performance goals include: 1. Extreme horizontal and vertical mobility - access to under-ice crevasses and glacier grounding- lines, close inspection and mapping. 2. Real-time exploration under direct human control. 3. Response to features of interest by altering sensing modality and trajectory as desired 4. Access to the calving front 5. Access to the under-ice boundary layer 6. Future manipulation, sample retrieval, and instrument emplacement capability Supported by NSF OPP under ANT-1126311, James Family Foundation, George Frederick Jewett Foundation East, and the Woods Hole Oceanographic Institution Fig. 1: Nereid-UI Concept of Operations. Table 1: Nereid-UI Specifications;

  19. Fabrication of Ce doped UiO-66/graphene nanocomposites with enhanced visible light driven photoactivity for reduction of nitroaromatic compounds

    NASA Astrophysics Data System (ADS)

    Yang, Zhiwang; Xu, Xueqing; Liang, Xixi; Lei, Cheng; Gao, Lihong; Hao, Ruoxue; Lu, Dedai; Lei, Ziqiang

    2017-10-01

    This study investigates the photocatalytic reduction of nitroaromatic compounds upon visible light over novel Ce-doped UiO-66/graphene nanocomposites. Ce doped UiO-66 nanostructures and the corresponding graphene hybridized nanocomposites were facilely synthesized by means of one step solvothermal reaction. It has been demonstrated that produced nanocomposites could be used as highly efficient and chemical stable photocatalysts for the reduction of nitroaromatic compounds under visible irradiation and ambient conditions. Compared with the bare UiO-66, Ce-UiO-66/GR distinctly enhanced photocatalytic activity. Ce as ;mediator; introduced into the MOFs materials can greatly improve the electron transfer across the interface between grephene and the UiO-66 and further improve the visible light driven photoactivity. This is an effective strategy for the development of high photocatalytic activity MOFs based materials.

  20. Utilizing the Southwest Ultraviolet Imaging System (SwUIS) on the International Space Station

    NASA Astrophysics Data System (ADS)

    Schindhelm, Eric; Stern, S. Alan; Ennico-Smith, Kimberly

    2013-09-01

    We present the Southwest Ultraviolet Imaging System (SwUIS), a compact, low-cost instrument designed for remote sensing observations from a manned platform in space. It has two chief configurations; a high spatial resolution mode with a 7-inch Maksutov-Cassegrain telescope, and a large field-of-view camera mode using a lens assembly. It can operate with either an intensified CCD or an electron multiplying CCD camera. Interchangeable filters and lenses enable broadband and narrowband imaging at UV/visible/near-infrared wavelengths, over a range of spatial resolution. SwUIS has flown previously on Space Shuttle flights STS-85 and STS-93, where it recorded multiple UV images of planets, comets, and vulcanoids. We describe the instrument and its capabilities in detail. The SWUIS's broad wavelength coverage and versatile range of hardware configurations make it an attractive option for use as a facility instrument for Earth science and astronomical imaging investigations aboard the International Space Station.

  1. Comparative Statistical Study of Some SAP UI Technologies

    NASA Astrophysics Data System (ADS)

    Berdie, Adela; Osaci, Mihaela; Dan Lemle, Ludovic

    2011-09-01

    The goal of this paper is to present a comparative study on some web UI (User Interface) technologies that involve the creation of web applications on the platform SAP Net Weaver AS 7.01 of the integrated SAP (System Application Products) system. The attention will be directed mainly to the ABAP (Advanced Business Application Programing) development environment and to the Web Dynpro (WD) technologies, Floor Plan Manager (FPM) and Web Client UI. Through this study, we make an assesment regarding the decision of choosing a technology for the realisation of a project which consists of a web application.

  2. The Remarkable Amphoteric Nature of Defective UiO‐66 in Catalytic Reactions

    PubMed Central

    Hajek, Julianna; Bueken, Bart; Waroquier, Michel; De Vos, Dirk

    2017-01-01

    Abstract One of the major requirements in solid acid and base catalyzed reactions is that the reactants, intermediates or activated complexes cooperate with several functions of catalyst support. In this work the remarkable bifunctional behavior of the defective UiO‐66(Zr) metal organic framework is shown for acid‐base pair catalysis. The active site relies on the presence of coordinatively unsaturated zirconium sites, which may be tuned by removing framework linkers and by removal of water from the inorganic bricks using a dehydration treatment. To elucidate the amphoteric nature of defective UiO‐66, the Oppenauer oxidation of primary alcohols has been theoretically investigated using density functional theory (DFT) and the periodic approach. The presence of acid and basic centers within molecular distances is shown to be crucial for determining the catalytic activity of the material. Hydrated and dehydrated bricks have a distinct influence on the acidity and basicity of the active sites. In any case both functions need to cooperate in a concerted way to enable the chemical transformation. Experimental results on UiO‐66 materials of different defectivity support the theoretical observations made in this work. PMID:28736581

  3. Mapping Education for the New Millennium: A UI Perspective.

    ERIC Educational Resources Information Center

    Heide, Tuula; Kozicki, Kim; Pedras, Melvin J.

    The College of Education at the University of Idaho (UI) is embarking on the first year of a project to restructure its teacher education program and refocus it to reflect national standards and place K-12 students at the center of preservice learning. Teacher education students are being prepared to meet the needs of school students through an…

  4. Liaison based assembly design

    SciTech Connect

    Ames, A.; Kholwadwala, D.; Wilson, R.H.

    1996-12-01

    Liaison Based Assembly Design extends the current information infrastructure to support design in terms of kinematic relationships between parts, or liaisons. These liaisons capture information regarding contact, degrees-of-freedom constraints and containment relationships between parts in an assembly. The project involved defining a useful collection of liaison representations, investigating their properties, and providing for maximum use of the data in downstream applications. We tested our ideas by implementing a prototype system involving extensions to Pro/Engineer and the Archimedes assembly planner. With an expanded product model, the design system is more able to capture design intent. When a product update is attempted, increased knowledge availability improves our ability to understand the effect of design changes. Manufacturing and analysis disciplines benefit from having liaison information available, so less time is wasted arguing over incomplete design specifications and our enterprise can be more completely integrated.

  5. 75 FR 22630 - Vital Signs Minnesota, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Paid...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-29

    ... Employment and Training Administration Vital Signs Minnesota, Inc., Including Workers Whose Unemployment... separate unemployment insurance (UI) tax account under the name Biomedical Dynamics Corporation... unemployment insurance (UI) wages are paid through Biomedical Dynamics Corporation, including on-site...

  6. Structure Ignition Assessment can help reduce fire damages in the W-UI

    Treesearch

    Jack Cohen; Jim Saveland

    1997-01-01

    The wildland-urban interface (W-UI) refers to residential areas surrounded by or adjacent to wildland areas. In recent years, significant W-UI residential fire losses have occurred nationwide in the United States that have focused attention on the principal W-UI problem - losses of life and property to fire. To assess potential ignitions, SIAM uses an analytical...

  7. 75 FR 26793 - Fypon, Ltd., Parkersburg, WV, Including Workers Whose Unemployment Insurance, (UI) Wages Are Paid...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ...] Fypon, Ltd., Parkersburg, WV, Including Workers Whose Unemployment Insurance, (UI) Wages Are Paid..., Including Workers Whose Unemployment Insurance, (UI) Wages Are Paid Through Therma-Tru Doors, Archbold, OH... reported under a separate unemployment insurance (UI) tax account under the name Therma-Tru Doors...

  8. 77 FR 3500 - Hugo Boss Cleveland, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Paid...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-24

    ... Cleveland, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Paid Through Tjfc... wages reported under a separate unemployment insurance (UI) tax account under the name TJFC Distribution...: All workers of Hugo Boss Cleveland, Inc., including workers whose unemployment insurance (UI) wages...

  9. WATERSHED BASED SURVEY DESIGNS

    EPA Science Inventory

    The development of watershed-based design and assessment tools will help to serve the multiple goals for water quality monitoring required under the Clean Water Act, including assessment of regional condition to meet Section 305(b), identification of impaired water bodies or wate...

  10. WATERSHED BASED SURVEY DESIGNS

    EPA Science Inventory

    The development of watershed-based design and assessment tools will help to serve the multiple goals for water quality monitoring required under the Clean Water Act, including assessment of regional condition to meet Section 305(b), identification of impaired water bodies or wate...

  11. Computer based satellite design

    NASA Astrophysics Data System (ADS)

    Lashbrook, David D.

    1992-06-01

    A computer program to design geosynchronous spacecraft has been developed. The program consists of four separate but interrelated executable computer programs. The programs are compiled to run on a DOS based personnel computer. The source code is written in DoD mandated Ada programming language. The thesis presents the design technique and design equations used in the program. Detailed analysis is performed in the following areas for both dual spin and three axis stabilized spacecraft configurations: (1) Mass Propellent Budget and Mass Summary; (2) Battery Cell and Solar Cell Requirements for a Payload Power Requirement; and (3) Passive Thermal Control Requirements. A user's manual is included as Appendix A, and the source code for the computer programs as Appendix B.

  12. UiO-66 MOF end-face-coated optical fiber in aqueous contaminant detection.

    PubMed

    Nazari, Marziyeh; Forouzandeh, Mohammad Ali; Divarathne, Chamath M; Sidiroglou, Fotios; Martinez, Marta Rubio; Konstas, Kristina; Muir, Benjamin W; Hill, Anita J; Duke, Mikel C; Hill, Matthew R; Collins, Stephen F

    2016-04-15

    Optical quality metal organic framework (MOF) thin films were integrated, for the first time, to the best of our knowledge, with structured optical fiber substrates to develop MOF-fiber sensors. The MOF-fiber structure, UiO-66 (Zr-based MOF is well known for its water stability), is a thin film that acts as an effective analyte collector. This provided a Fabry-Perot sensor in which concentrations of up to 15 mM Rhodamine-B were detected via wavelength shifts in the interference spectrum.

  13. Definitive molecular level characterization of defects in UiO-66 crystals.

    PubMed

    Trickett, Christopher A; Gagnon, Kevin J; Lee, Seungkyu; Gándara, Felipe; Bürgi, Hans-Beat; Yaghi, Omar M

    2015-09-14

    The identification and characterization of defects, on the molecular level, in metal-organic frameworks (MOFs) remain a challenge. With the extensive use of single-crystal X-ray diffraction (SXRD), the missing linker defects in the zirconium-based MOF UiO-66, Zr6 O4 (OH)4 (C8 H4 O4 )6 , have been identified as water molecules coordinated directly to the zirconium centers. Charge balancing is achieved by hydroxide anions, which are hydrogen bonded within the pores of the framework. Furthermore, the precise nature of the defects and their concentration can be manipulated by altering the starting materials, synthesis conditions, and post-synthetic modifications.

  14. Modular user interface design for integrated surgical workplaces.

    PubMed

    Benzko, Julia; Krause, Lisa; Janß, Armin; Marschollek, Björn; Merz, Paul; Dell'Anna, Jasmin; Radermacher, Klaus

    2016-04-01

    Severe bottlenecks in usability and human technology interaction (HTI) of existing surgical workplaces and operating room (OR) equipment can occur today: lack of space, cable as trip hazard, communication problems between sterile and non-sterile staff, and operating errors in the handling of the medical devices. In fact, risks that are caused by poor usability can be critical, and studies show that most are preventable. This issue gets even more challenging in the context of open-OR networks regarding consistent and usable integration of user interfaces (UIs) of independently designed systems in one integrated surgical work system. In this work, a concept of generic UI profiles for the modular integration of a UI has been developed and first prototypes have been implemented. The concept is essentially based on the approach of device profiles developed in the context of the Bundesministerium für Bildung und Forschung project OR.NET (www.ornet.org). We developed generic UI profiles to map the different interfaces of the medical devices on an integrated surgical UI. The integrated UI design shall be automatically verified according to agreed usability criteria, guidelines, and human error taxonomies.

  15. Sprinkler arrangement for UiTM's stadium field

    NASA Astrophysics Data System (ADS)

    Abdullah, Nur Lina; Kadir, Norhidayah A.; Safaron, Saiful Bahri; Suder, Nurazeera Md; Omar, Nurul Wahidah

    2013-09-01

    The purpose of this paper is to study the arrangement of water sprinkler at Universiti Teknologi MARA (UiTM), Shah Alam stadium field. There are 35 number of sprinklers used with 7 × 5 arrangement. The current problem is that as there are too many sprinkler used, the overlapping area becomes too large and hence leads to waste. In order to minimize the number of sprinklers used as well as the overlapping area, new arrangement of sprinklers is proposed. The validity of the developed arrangement is tested by using Microsoft Excel and mathematical software, MAPLE 14. Finally, there are six possible arrangements that can be used to replace the current arrangement.

  16. Design and implementation of a cloud based lithography illumination pupil processing application

    NASA Astrophysics Data System (ADS)

    Zhang, Youbao; Ma, Xinghua; Zhu, Jing; Zhang, Fang; Huang, Huijie

    2017-02-01

    Pupil parameters are important parameters to evaluate the quality of lithography illumination system. In this paper, a cloud based full-featured pupil processing application is implemented. A web browser is used for the UI (User Interface), the websocket protocol and JSON format are used for the communication between the client and the server, and the computing part is implemented in the server side, where the application integrated a variety of high quality professional libraries, such as image processing libraries libvips and ImageMagic, automatic reporting system latex, etc., to support the program. The cloud based framework takes advantage of server's superior computing power and rich software collections, and the program could run anywhere there is a modern browser due to its web UI design. Compared to the traditional way of software operation model: purchased, licensed, shipped, downloaded, installed, maintained, and upgraded, the new cloud based approach, which is no installation, easy to use and maintenance, opens up a new way. Cloud based application probably is the future of the software development.

  17. Efficient alkene epoxidation catalyzed by molybdenyl acetylacetonate supported on aminated UiO-66 metal-organic framework

    NASA Astrophysics Data System (ADS)

    Kardanpour, Reihaneh; Tangestaninejad, Shahram; Mirkhani, Valiollah; Moghadam, Majid; Mohammadpoor-Baltork, Iraj; Zadehahmadi, Farnaz

    2015-03-01

    Metal-organic frameworks (MOFs) containing Mo Schiff base complexes were prepared by post-synthesis method and applied as efficient catalysts in the epoxidation of alkenes with tert-BuOOH. In this manner, UiO-66-NH2 (UiO=University of Oslo) MOF was reacted with salicylaldehyde and thiophene-2-carbaldehyde to produce bidentate Schiff bases. Then, the Schiff base ligands were used for immobilization of molybdenyl acetylacetonate. These new catalysts were characterized by FT-IR, UV-vis spectroscopic techniques, X-ray diffraction (XRD), BET, inductively coupled plasma atomic emission spectroscopy (ICP-AES) and field emission scanning electron microscopy (FE-SEM). These catalytic systems showed excellent activity in the epoxidation of alkenes such as cyclic and linear ones with tert-butyl hydroperoxide (TBHP) in 1,2-dichloroethane, and reused several times without any appreciable loss of their activity.

  18. The Ultrasonic Inspection System (UIS) for inspection of steam generator materials of NPP`s VVER440

    SciTech Connect

    Kuna, M.; Macecek, M.

    1994-12-31

    Ultrasonic Inspection System (UIS) is a complex ultrasonic control system working in conjunction with a mechanical manipulator which provides a complete evaluation of collected data. The system was designed and manufactured by Techno Scientific Inc. (TSI) in Woodbridge, Ontario, Canada to specifications by the Nuclear Power Plants Research Institute for full compatibility with manipulator ZOK PG1. The system is used for the automated control of material and welds of primary collectors of steam generator of Nuclear Plants VVER440. The control unit of the manipulator acts as a master to UIS and synchronizes data collection with the reading of co-ordinates for ultrasonic probes. Data is evaluated by software. Defect sizing and 3D displays are performed.

  19. Efficient alkene epoxidation catalyzed by molybdenyl acetylacetonate supported on aminated UiO-66 metal−organic framework

    SciTech Connect

    Kardanpour, Reihaneh; Tangestaninejad, Shahram; Mirkhani, Valiollah; Moghadam, Majid; Mohammadpoor-Baltork, Iraj; Zadehahmadi, Farnaz

    2015-03-15

    Metal–organic frameworks (MOFs) containing Mo Schiff base complexes were prepared by post-synthesis method and applied as efficient catalysts in the epoxidation of alkenes with tert-BuOOH. In this manner, UiO-66-NH{sub 2} (UiO=University of Oslo) MOF was reacted with salicylaldehyde and thiophene-2-carbaldehyde to produce bidentate Schiff bases. Then, the Schiff base ligands were used for immobilization of molybdenyl acetylacetonate. These new catalysts were characterized by FT-IR, UV–vis spectroscopic techniques, X-ray diffraction (XRD), BET, inductively coupled plasma atomic emission spectroscopy (ICP-AES) and field emission scanning electron microscopy (FE-SEM). These catalytic systems showed excellent activity in the epoxidation of alkenes such as cyclic and linear ones with tert-butyl hydroperoxide (TBHP) in 1,2-dichloroethane, and reused several times without any appreciable loss of their activity. - Graphical abstract: Efficient alkene epoxidation with TBHP catalyzed by heterogeneous and reusable molybdenum base catalysts is reported. - Highlights: • UiO-66-NH{sub 2} was modified with salicylaldehyde and thiophene-2-carbaldehyde. • The Schiff base groups were used for immobilization of MoO{sub 2}(acac){sub 2}. • The heterogeneous catalysts were prepared. • The prepared catalysts were used for epoxidation of alkenes. • Compared to other catalyst, our catalysts were more efficient and forceful.

  20. Relationship of saving habit determinants among undergraduate students: A case study of UiTM Negeri Sembilan, Kampus Seremban

    NASA Astrophysics Data System (ADS)

    Syahrom, N. S.; Nasrudin, N. S.; Mohamad Yasin, N.; Azlan, N.; Manap, N.

    2017-08-01

    It has been reported that students are already accumulating substantial debt from higher education fees and their spending habit are at a critical stage. These situations cause the youngsters facing bankruptcy if they cannot improve their saving habit. Many researches have acknowledged that the determinants of saving habit include financial management, parental socialization, peer influence, and self-control. However, there remains a need for investigating the relationship between these determinants in order to avoid bankruptcy among youngsters. The objectives of this study are to investigate the relationship between saving habit determinants and to generate a statistical model based on the determinants of saving habit. Data collection method used is questionnaire and its scope is undergraduate students of UiTM Negeri Sembilan, Kampus Seremban. Samples are chosen by using stratified probability sampling technique and cross-sectional method is used as the research design. The results are then analysed by using descriptive analysis, reliability test, Pearson Correlation, and Multiple Linear Regression analysis. It shows that saving habit and self-control has no relationship. It means that students with less self-control tend to save less. A statistical model has been generated that incorporated this relationship. This study is significant to help the students save more by having high self-control.

  1. American white pelican predation on Cui-ui in Pyramid Lake, Nevada

    USGS Publications Warehouse

    Scoppettone, Gayton G.; Rissler, Peter H.; Fabes, Mark C.; Withers, Donna

    2014-01-01

    Anthropogenic changes to the Pyramid Lake–Truckee River ecosystem in Nevada are suspected to have altered the predator–prey balance between American white pelican Pelecanus erythrorhynchos and Cui-ui Chasmistes cujus. We estimated the loss of the adult Cui-ui population to pelican predation over a 13-year period by netting and tagging Cui-uis as they aggregated at the mouth of the Truckee River prior to their spawning migration into the Truckee River. Cui-ui access to the Truckee River typically required traversing a shallow delta (a foraging advantage for these American white pelicans). Dams and greater frequency of low stream flows also contributed to American white pelican foraging success. We used tag recoveries from Pyramid Lake's nesting colony of American white pelicans along with an experiment to estimate the chance of tag recovery within the colony to calculate the number of tagged fish taken by American white pelicans. We also used numbered tags to test whether there was a size preference for Cui-uis taken. Our results showed that the primary source of adult Cui-ui mortality was from American white pelican predation in the Truckee River. Within a 13-year period American white pelicans had taken 90% of the tags deployed during the first 7 years of the interval. There was no preference for the size of Cui-uis taken. A better understanding of the effects of heavy cropping by American white pelicans on Cui-ui population dynamics is still needed.

  2. UIS2: A Unique Phosphatase Required for the Development of Plasmodium Liver Stages

    PubMed Central

    Zhang, Min; Mishra, Satish; Sakthivel, Ramanavelan; Fontoura, Beatriz M. A.; Nussenzweig, Victor

    2016-01-01

    Plasmodium salivary sporozoites are the infectious form of the malaria parasite and are dormant inside salivary glands of Anopheles mosquitoes. During dormancy, protein translation is inhibited by the kinase UIS1 that phosphorylates serine 59 in the eukaryotic initiation factor 2α (eIF2α). De-phosphorylation of eIF2α-P is required for the transformation of sporozoites into the liver stage. In mammalian cells, the de-phosphorylation of eIF2α-P is mediated by the protein phosphatase 1 (PP1). Using a series of genetically knockout parasites we showed that in malaria sporozoites, contrary to mammalian cells, the eIF2α-P phosphatase is a member of the PP2C/PPM phosphatase family termed UIS2. We found that eIF2α was highly phosphorylated in uis2 conditional knockout sporozoites. These mutant sporozoites maintained the crescent shape after delivery into mammalian host and lost their infectivity. Both uis1 and uis2 were highly transcribed in the salivary gland sporozoites but uis2 expression was inhibited by the Pumilio protein Puf2. The repression of uis2 expression was alleviated when sporozoites developed into liver stage. While most eukaryotic phosphatases interact transiently with their substrates, UIS2 stably bound to phosphorylated eIF2α, raising the possibility that high-throughput searches may identify chemicals that disrupt this interaction and prevent malaria infection. PMID:26735921

  3. The Changing UI Claimant Population: Is It Time To Retool Reemployment Services? Issue Brief.

    ERIC Educational Resources Information Center

    Needels, Karen; Corson, Walter; Nicholson, Walter

    Data from national administrative and telephone surveys of nationally representative samples of unemployment insurance (UI) recipients who began collecting benefits in 1998 were analyzed to identify changes in the UI claimant population over the past 10 years and determine whether the time has come to retool the nation's reemployment services. The…

  4. Supporting our scientists with Google Earth-based UIs.

    SciTech Connect

    Scott, Janine

    2010-10-01

    Google Earth and Google Maps are incredibly useful for researchers looking for easily-digestible displays of data. This presentation will provide a step-by-step tutorial on how to begin using Google Earth to create tools that further the mission of the DOE national lab complex.

  5. Data Mining of Acupoint Characteristics from the Classical Medical Text: DongUiBoGam of Korean Medicine

    PubMed Central

    Lee, Taehyung; Jung, Won-Mo; Lee, In-Seon; Lee, Ye-Seul; Lee, Hyejung; Park, Hi-Joon; Kim, Namil; Chae, Younbyoung

    2014-01-01

    Throughout the history of East Asian medicine, different kinds of acupuncture treatment experiences have been accumulated in classical medical texts. Reexamining knowledge from classical medical texts is expected to provide meaningful information that could be utilized in current medical practices. In this study, we used data mining methods to analyze the association between acupoints and patterns of disorder with the classical medical book DongUiBoGam of Korean medicine. Using the term frequency-inverse document frequency (tf-idf) method, we quantified the significance of acupoints to its targeting patterns and, conversely, the significance of patterns to acupoints. Through these processes, we extracted characteristics of each acupoint based on its treating patterns. We also drew practical information for selecting acupoints on certain patterns according to their association. Data analysis on DongUiBoGam's acupuncture treatment gave us an insight into the main idea of DongUiBoGam. We strongly believe that our approach can provide a novel understanding of unknown characteristics of acupoint and pattern identification from the classical medical text using data mining methods. PMID:25574179

  6. Cui-ui reproductive success from potential egg deposition to larval emigration

    USGS Publications Warehouse

    Scoppettone, G. Gary; Rissler, Peter H.

    2012-01-01

    From 1985 to 2006, we tracked cui-ui, Chasmistes cujus, survival from potential egg deposition of migrating spawners to emigrating larvae. Tahoe sucker larvae emigrated to Pyramid Lake the same time as cui-ui larvae, but cui-ui was the predominant catostomid larvae we captured. Survival of cui-ui larvae ranged from 0.46% to 21.17%, declining significantly with decreased flow and increased number of spawners (P < 0.01). Mean total length of emigrating larvae ranged from 11.5 to 12.6 mm and may have been affected by stream flow. Removal of impediments to upstream migrating cui-ui spawners, along with sufficient stream flows, may enhance early life-stage survival.

  7. Free Energy of Ligand Removal in the Metal–Organic Framework UiO-66

    PubMed Central

    2016-01-01

    We report an investigation of the “missing-linker phenomenon” in the Zr-based metal–organic framework UiO-66 using atomistic force field and quantum chemical methods. For a vacant benzene dicarboxylate ligand, the lowest energy charge-capping mechanism involves acetic acid or Cl–/H2O. The calculated defect free energy of formation is remarkably low, consistent with the high defect concentrations reported experimentally. A dynamic structural instability is identified for certain higher defect concentrations. In addition to the changes in material properties upon defect formation, we assess the formation of molecular aggregates, which provide an additional driving force for ligand loss. These results are expected to be of relevance to a wide range of metal–organic frameworks. PMID:27610208

  8. Facile syntheses of pure uranium halides: UCl4, UBr4 and UI4.

    PubMed

    Rudel, Stefan S; Kraus, Florian

    2017-05-09

    Herein we describe convenient lab scale syntheses of several uranium(iv) halides of high purity by reaction of AlX3 (X = Cl, Br and I) with UO2, which is readily available by reduction of uranyl salts like UO2(NO3)2·6H2O. UCl4, UBr4, and UI4 are obtained in the form of aggregates of large single crystals. Their identities and purity were checked by powder X-ray diffraction, IR spectroscopy and elemental analysis. The syntheses introduced here avoid the need for pure metallic uranium and are based on more readily available starting materials, UO2, which does not even have to be pure, and the respective aluminium halide. Chemical vapor transport (CVT) is applied in situ for purification of the products.

  9. Lunar base and Mars base design projects

    NASA Technical Reports Server (NTRS)

    Amos, J.; Campbell, J.; Hudson, C.; Kenny, E.; Markward, D.; Pham, C.; Wolf, C.

    1989-01-01

    The space design classes at the University of Texas at Austin undertook seven projects in support of the NASA/USRA advanced space design program during the 1988-89 year. A total of 51 students, including 5 graduate students, participated in the design efforts. Four projects were done within the Aerospace Engineering (ASE) design program and three within the Mechanical Engineering (ME) program. Both lunar base and Mars base design efforts were studied, and the specific projects were as follows: Lunar Crew Emergency Rescue Vehicle (ASE); Mars Logistics Lander Convertible to a Rocket Hopper (ME); A Robotically Constructed Production and Supply Base on Phobos (ASE); A Mars/Phobos Transportation System (ASE); Manned Base Design and Related Construction Issues for Mars/Phobos Mission (ME); and Health Care Needs for a Lunar Colony and Design of Permanent Medical Facility (ME).

  10. Lunar base and Mars base design projects

    NASA Technical Reports Server (NTRS)

    Amos, J.; Campbell, J.; Hudson, C.; Kenny, E.; Markward, D.; Pham, C.; Wolf, C.

    1989-01-01

    The space design classes at the University of Texas at Austin undertook seven projects in support of the NASA/USRA advanced space design program during the 1988-89 year. A total of 51 students, including 5 graduate students, participated in the design efforts. Four projects were done within the Aerospace Engineering (ASE) design program and three within the Mechanical Engineering (ME) program. Both lunar base and Mars base design efforts were studied, and the specific projects were as follows: Lunar Crew Emergency Rescue Vehicle (ASE); Mars Logistics Lander Convertible to a Rocket Hopper (ME); A Robotically Constructed Production and Supply Base on Phobos (ASE); A Mars/Phobos Transportation System (ASE); Manned Base Design and Related Construction Issues for Mars/Phobos Mission (ME); and Health Care Needs for a Lunar Colony and Design of Permanent Medical Facility (ME).

  11. Programming MOFs for water sorption: amino-functionalized MIL-125 and UiO-66 for heat transformation and heat storage applications.

    PubMed

    Jeremias, Felix; Lozan, Vasile; Henninger, Stefan K; Janiak, Christoph

    2013-12-07

    Sorption-based heat transformation and storage appliances are very promising for utilizing solar heat and waste heat in cooling or heating applications. The economic and ecological efficiency of sorption-based heat transformation depends on the availability of suitable hydrophilic and hydrothermally stable sorption materials. We investigated the feasibility of using the metal-organic frameworks UiO-66(Zr), UiO-67(Zr), H2N-UiO-66(Zr) and H2N-MIL-125(Ti) as sorption materials in heat transformations by means of volumetric water adsorption measurements, determination of the heat of adsorption and a 40-cycle ad/desorption stress test. The amino-modified compounds H2N-UiO-66 and H2N-MIL-125 feature high heat of adsorption (89.5 and 56.0 kJ mol(-1), respectively) and a very promising H2O adsorption isotherm due to their enhanced hydrophilicity. For H2N-MIL-125 the very steep rise of the H2O adsorption isotherm in the 0.1 < p/p0 < 0.2 region is especially beneficial for the intended heat pump application.

  12. Limitations of anticholinergic cycling in patients with overactive bladder (OAB) with urinary incontinence (UI): results from the CONsequences of Treatment Refractory Overactive bLadder (CONTROL) study.

    PubMed

    Chancellor, Michael B; Yehoshua, Alon; Waweru, Catherine; Globe, Denise; Cheng, I-Ning; Campbell, Karen L; Joshi, Manher; Pulicharam, Riya

    2016-07-01

    To describe treatment patterns and outcomes in wet-overactive bladder (OAB) patients treated with anticholinergics. This study was a retrospective claims analysis linked to a one-time patient survey of members of a regional medical group located in California. Participants met the following criteria: received anticholinergic therapy between January 2008 and May 2012, based on pharmacy claims; had a diagnosis of OAB; and reported having ≥1 urinary incontinence (UI) episode per day at the time of the survey. Outcomes included the number of anticholinergics cycled through from treatment initiation until the end of follow-up (May 31, 2013); frequency of UI episodes; and patient requests for additional help for their OAB symptoms. A total of 620 patients were enrolled into the study. During the follow-up period, patients cycled through 1 to 6 unique anticholinergics; 65 % of the study population used only 1 anticholinergic, while 35 % used ≥2 anticholinergics. Patients reported experiencing an average of 3.5 UI episodes per day (3.6, 3.3, and 3.4 episodes for 1, 2, and ≥3 anticholinergics used, respectively), and over 80 % of patients requested additional help for their OAB symptoms, irrespective of how many anticholinergics were attempted. UI symptom burden and adherence to therapy did not change as patients attempted more anticholinergic therapies. These results suggest that for patients who remain incontinent after attempting an anticholinergic, cycling on additional anticholinergics may not provide any additional benefit, resulting in sub-optimal care.

  13. 75 FR 34170 - Circuit Science, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Reported...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... Employment and Training Administration Circuit Science, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Are Reported Through Circuit Test; Plymouth, MN; Amended Certification Regarding... to Apply for Worker Adjustment Assistance on November 30, 2009, applicable to workers of Circuit...

  14. 75 FR 22846 - Norgren Automation Solutions, Including Workers Whose Unemployment Insurance (UI) Wages Are Paid...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... Employment and Training Administration Norgren Automation Solutions, Including Workers Whose Unemployment Insurance (UI) Wages Are Paid Through Syron Engineering Erie Engineering and Automation Division, A... Adjustment Assistance on January 29, 2010, applicable to workers of Norgren Automation Solutions, Erie...

  15. 77 FR 54927 - Comment Request for Information Collection for Unemployment Insurance (UI) Benefit Accuracy...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... Employment and Training Administration Comment Request for Information Collection for Unemployment Insurance (UI) Benefit Accuracy Measurement (BAM), Extension Without Revisions. AGENCY: Employment and Training... written comments to Andrew Spisak, Office of Unemployment Insurance, Room S-4524, Employment and Training...

  16. Role-Based Design: Design Experiences

    ERIC Educational Resources Information Center

    Miller, Charles; Hokanson, Brad; Doering, Aaron; Brandt, Tom

    2010-01-01

    This is the fourth and final installment in a series of articles presenting a new outlook on the methods of instructional design. These articles examine the nature of the process of instructional design and are meant to stimulate discussion about the roles of designers in the fields of instructional design, the learning sciences, and interaction…

  17. Role-Based Design: Design Experiences

    ERIC Educational Resources Information Center

    Miller, Charles; Hokanson, Brad; Doering, Aaron; Brandt, Tom

    2010-01-01

    This is the fourth and final installment in a series of articles presenting a new outlook on the methods of instructional design. These articles examine the nature of the process of instructional design and are meant to stimulate discussion about the roles of designers in the fields of instructional design, the learning sciences, and interaction…

  18. Reusing Design Knowledge Based on Design Cases and Knowledge Map

    ERIC Educational Resources Information Center

    Yang, Cheng; Liu, Zheng; Wang, Haobai; Shen, Jiaoqi

    2013-01-01

    Design knowledge was reused for innovative design work to support designers with product design knowledge and help designers who lack rich experiences to improve their design capacity and efficiency. First, based on the ontological model of product design knowledge constructed by taxonomy, implicit and explicit knowledge was extracted from some…

  19. Reusing Design Knowledge Based on Design Cases and Knowledge Map

    ERIC Educational Resources Information Center

    Yang, Cheng; Liu, Zheng; Wang, Haobai; Shen, Jiaoqi

    2013-01-01

    Design knowledge was reused for innovative design work to support designers with product design knowledge and help designers who lack rich experiences to improve their design capacity and efficiency. First, based on the ontological model of product design knowledge constructed by taxonomy, implicit and explicit knowledge was extracted from some…

  20. Improvements in bracket base design.

    PubMed

    Smith, D C; Maijer, R

    1983-04-01

    Acid etch bonding of orthodontic attachments to the labial and lingual surfaces of teeth is generally adequate for clinical service. Failures do occur, and these are related to technique problems in acid etching or resin manipulation or to bracket base design. The widely used foil mesh base can present problems in retention because of design defects or corrosion. Improvement in mechanical retention of resin to the attachment base would result in significant improvements in bonding and fewer clinical failures. One of our approaches to improved retention is to fuse metallic or ceramic particles onto the bracket base so as to achieve a particulate or porous layer into which resin can penetrate. The results of bond-strength tests showed that a 100 percent increase in bond strength could be obtained with sintered porous metal-coated brackets. Further development is proceeding.

  1. Family of the Sun-and-Stars Time-Determining Instruments (Ilseong-jeongsi-ui) Invented During the Joseon Dynasty

    NASA Astrophysics Data System (ADS)

    Lee, Yong Sam; Kim, Sang Hyuk; Mihn, Byeong-Hee

    2016-09-01

    We analyze the design and specifications of the Sun-and-Stars Time-Determining group of instruments (Ilseong-jeongsi-ui, 日星定時儀) made during the Joseon dynasty. According to the records of the Sejong Sillok (Veritable Records of King Sejong), Sun-and-Stars Time-Determining Instruments measure the solar time of day and the sidereal time of night through three rings and an alidade. One such instrument, the Simplified Time-Determining Instrument (So-jeongsi-ui, 小定時儀), is made without the essential component for alignment with the celestial north pole. Among this group of instruments, only two bronze Hundred-Interval-Ring Sundials (Baekgak-hwan-Ilgu, 百刻環日晷) currently exist. A comparison of the functions of these two relics with two Time-Determining Instruments suggests that the Hundred-Interval-Ring Sundial is a Simplified Sundial (So-ilyeong, 小日影), as recorded in the Sejong Sillok and the Seongjong Sillok (Veritable Records of King Seongjong). Furthermore, the Simplified Sundial is a model derived from the Simplified Time-Determining Instrument. During the King Sejong reign, the Sun-and-Stars Time-Determining Instruments were used in military camps of the kingdom’s frontiers, in royal ancestral rituals, and in royal astronomical observatories.

  2. DISPLACEMENT BASED SEISMIC DESIGN CRITERIA

    SciTech Connect

    HOFMAYER,C.H.

    1999-03-29

    The USNRC has initiated a project to determine if any of the likely revisions to traditional earthquake engineering practice are relevant to seismic design of the specialized structures, systems and components of nuclear power plants and of such significance to suggest that a change in design practice might be warranted. As part of the initial phase of this study, a literature survey was conducted on the recent changes in seismic design codes/standards, on-going activities of code-writing organizations/communities, and published documents on displacement-based design methods. This paper provides a summary of recent changes in building codes and on-going activities for future codes. It also discusses some technical issues for further consideration.

  3. WATERSHED-BASED SURVEY DESIGNS

    EPA Science Inventory

    Water-based sampling design and assessment tools help serve the multiple goals for water quality monitoring required under the Clean Water Act, including assessment of regional conditions to meet Section 305(b), identification if impaired water bodies or watersheds to meet Sectio...

  4. Design-Based Implementation Research

    ERIC Educational Resources Information Center

    LeMahieu, Paul G.; Nordstrum, Lee E.; Potvin, Ashley Seidel

    2017-01-01

    Purpose: This paper is second of seven in this volume elaborating different approaches to quality improvement in education. It delineates a methodology called design-based implementation research (DBIR). The approach used in this paper is aimed at iteratively improving the quality of classroom teaching and learning practices in defined problem…

  5. WATERSHED-BASED SURVEY DESIGNS

    EPA Science Inventory

    Water-based sampling design and assessment tools help serve the multiple goals for water quality monitoring required under the Clean Water Act, including assessment of regional conditions to meet Section 305(b), identification if impaired water bodies or watersheds to meet Sectio...

  6. Design-Based Implementation Research

    ERIC Educational Resources Information Center

    LeMahieu, Paul G.; Nordstrum, Lee E.; Potvin, Ashley Seidel

    2017-01-01

    Purpose: This paper is second of seven in this volume elaborating different approaches to quality improvement in education. It delineates a methodology called design-based implementation research (DBIR). The approach used in this paper is aimed at iteratively improving the quality of classroom teaching and learning practices in defined problem…

  7. Watershed-based survey designs

    USGS Publications Warehouse

    Detenbeck, N.E.; Cincotta, D.; Denver, J.M.; Greenlee, S.K.; Olsen, A.R.; Pitchford, A.M.

    2005-01-01

    Watershed-based sampling design and assessment tools help serve the multiple goals for water quality monitoring required under the Clean Water Act, including assessment of regional conditions to meet Section 305(b), identification of impaired water bodies or watersheds to meet Section 303(d), and development of empirical relationships between causes or sources of impairment and biological responses. Creation of GIS databases for hydrography, hydrologically corrected digital elevation models, and hydrologic derivatives such as watershed boundaries and upstream–downstream topology of subcatchments would provide a consistent seamless nationwide framework for these designs. The elements of a watershed-based sample framework can be represented either as a continuous infinite set defined by points along a linear stream network, or as a discrete set of watershed polygons. Watershed-based designs can be developed with existing probabilistic survey methods, including the use of unequal probability weighting, stratification, and two-stage frames for sampling. Case studies for monitoring of Atlantic Coastal Plain streams, West Virginia wadeable streams, and coastal Oregon streams illustrate three different approaches for selecting sites for watershed-based survey designs.

  8. Watershed-based survey designs.

    PubMed

    Detenbeck, Naomi E; Cincotta, Dan; Denver, Judith M; Greenlee, Susan K; Olsen, Anthony R; Pitchford, Ann M

    2005-04-01

    Watershed-based sampling design and assessment tools help serve the multiple goals for water quality monitoring required under the Clean Water Act, including assessment of regional conditions to meet Section 305(b), identification of impaired water bodies or watersheds to meet Section 303(d), and development of empirical relationships between causes or sources of impairment and biological responses. Creation of GIS databases for hydrography, hydrologically corrected digital elevation models, and hydrologic derivatives such as watershed boundaries and upstream-downstream topology of subcatchments would provide a consistent seamless nationwide framework for these designs. The elements of a watershed-based sample framework can be represented either as a continuous infinite set defined by points along a linear stream network, or as a discrete set of watershed polygons. Watershed-based designs can be developed with existing probabilistic survey methods, including the use of unequal probability weighting, stratification, and two-stage frames for sampling. Case studies for monitoring of Atlantic Coastal Plain streams, West Virginia wadeable streams, and coastal Oregon streams illustrate three different approaches for selecting sites for watershed-based survey designs.

  9. Tailoring the Adsorption and Reaction Chemistry of the Metal-Organic Frameworks UiO-66, UiO-66-NH2, and HKUST-1 via the Incorporation of Molecular Guests.

    PubMed

    Ploskonka, Ann M; DeCoste, Jared B

    2017-06-28

    Metal-organic frameworks (MOFs) are versatile materials highly regarded for their porous nature. Depending on the synthetic method, various guest molecules may remain in the pores or can be systematically loaded for various reasons. Herein, we present a study that explores the effect of guest molecules on the adsorption and reactivity of the MOF in both the gas phase and solution. The differences between guest molecule interactions and the subsequent effects on their activity are described for each system. Interestingly, different effects are observed and described in detail for each class of guest molecules studied. We determine that there is a strong effect of alcohols with the secondary building unit of UiO MOFs, while Lewis bases have an effect on the reactivity of the -NH2 group in UiO-66-NH2 and adsorption by the coordinatively unsaturated copper sites in HKUST-1. These effects must be considered when determining synthesis and activation methods of MOFs toward various applications.

  10. Upper incisor to Soft Tissue Plane (UI-STP): a new reference for diagnosis and planning in dentofacial deformities.

    PubMed

    Hernandez-Alfaro, Federico

    2010-09-01

    Planning in orthognathic surgery has been and still is an open issue. We have evolved from 2D classical cephalometric hard-tissue planning to 2D soft tissue planning, and finally to 3D and hard and soft tissue evaluation. This, to our knowledge, is the first description of a new Soft Tissue Plane (STP) and its relationship with the anterior position of the upper incisor (UI). Profile photographs of 110 "attractive individuals" with lips at rest or smiling and with upper incisor shown were used. The photographs used were of 65 professional models from two international agencies and 45 individuals considered most attractive in the internet forums, which included catwalk models and actors. In 86 cases (78.18 %), the incisor was located in front of the STP (A). In 15 cases (13.63%), it was on the plane (N); and in the remaining 9 cases (8.18%), it was behind (P). Despite the limitations of this study and based on our series, we can conclude that the upper incisor is located at or in front of the Soft Tissue Plane (STP) in 91.81% of the attractive facial profiles studied. On the other hand, the relative position of the upper incisor to the soft tissue plane (UI-STP) could be a useful diagnostic and planning tool in orthodontic and surgical management of dentofacial deformities.

  11. Boron-Based Drug Design.

    PubMed

    Ban, Hyun Seung; Nakamura, Hiroyuki

    2015-06-01

    The use of the element boron, which is not generally observed in a living body, possesses a high potential for the discovery of new biological activity in pharmaceutical drug design. In this account, we describe our recent developments in boron-based drug design, including boronic acid containing protein tyrosine kinase inhibitors, proteasome inhibitors, and tubulin polymerization inhibitors, and ortho-carborane-containing proteasome activators, hypoxia-inducible factor 1 inhibitors, and topoisomerase inhibitors. Furthermore, we applied a closo-dodecaborate as a water-soluble moiety as well as a boron-10 source for the design of boron carriers in boron neutron capture therapy, such as boronated porphyrins and boron lipids for a liposomal boron delivery system.

  12. Model-based software design

    NASA Technical Reports Server (NTRS)

    Iscoe, Neil; Liu, Zheng-Yang; Feng, Guohui; Yenne, Britt; Vansickle, Larry; Ballantyne, Michael

    1992-01-01

    Domain-specific knowledge is required to create specifications, generate code, and understand existing systems. Our approach to automating software design is based on instantiating an application domain model with industry-specific knowledge and then using that model to achieve the operational goals of specification elicitation and verification, reverse engineering, and code generation. Although many different specification models can be created from any particular domain model, each specification model is consistent and correct with respect to the domain model.

  13. Base Camp Design Simulation Training

    DTIC Science & Technology

    2011-07-01

    28 Location 2D Map View (note you are to select a location within the NW region of Yousel Khel) 29 3D Camera View...Figure 3: 2D Representation of Yousel Khel The scenario forces the student to conduct trade-off analysis as competing interests (proximity to a...reason, we designed a 600-man base camp on VBS2TM from an AutoCAD diagram found on the Theater Construction Management System (version 3.2). Known

  14. Value-based Insurance Design.

    PubMed

    Sharan, Alok D; Schroeder, Gregory D; West, Michael E; Vaccaro, Alexander R

    2017-03-01

    The increasing awareness of the scarcity of health care resources is forcing the health care industry to improve quality while lowering the cost. One method by which employers and insurance companies are attempting to do this is with value-based insurance design. In these plans, patients pay a lower amount for certain services that are considered high value and a higher amount for services that are considered low value.

  15. Value-based Insurance Design.

    PubMed

    Sharan, Alok D; Schroeder, Gregory D; West, Michael E; Vaccaro, Alexander R

    2017-02-17

    The increasing awareness of the scarcity of health care resources is forcing the health care industry to improve quality while lowering the cost. One method by which employers and insurance companies are attempting to do this is with value-based insurance design. In these plans, patients pay a lower amount for certain services that are considered high value and a higher amount for services that are considered low value.

  16. Intuitive user interface for mobile devices based on visual motion detection

    NASA Astrophysics Data System (ADS)

    Winkler, Stefan; Rangaswamy, Karthik; Zhou, ZhiYing

    2007-02-01

    The small form factor and unergonomic keys of mobile phones call for new and more natural approaches in user interface (UI) design. In this paper, we propose intuitive motion-based UI controls for mobile devices with built-in cameras based on the visual detection of the device's self-motion. We developed a car-racing game to test our new interface, and we conducted a user study to evaluate the accuracy, sensitivity, responsiveness and usability of our proposed system. Results show that our motion-based interface is well received by the users and clearly preferred over traditional button-based controls.

  17. 78 FR 51211 - Announcement Regarding a Change in Eligibility for Unemployment Insurance (UI) Claimants in...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... Insurance (UI) Claimants in Louisiana, Maine, New Jersey, West Virginia and the Virgin Islands in the... Tier 4 eligibility. The Virgin Islands has triggered ``on'' to Tier 2 and Tier 3 of EUC08 effective... three month average, seasonally adjusted total unemployment rate in the Virgin Islands was 7.6 percent...

  18. 78 FR 12655 - Federal-State Unemployment Insurance (UI) Program; Data Exchange Standardization as Required by...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-25

    ... Employment and Training Administration 20 CFR Part 619 RIN 1205-AB64 Federal-State Unemployment Insurance (UI... Creation Act of 2012 AGENCY: Employment and Training Administration, Labor. ACTION: Notice of proposed rulemaking. SUMMARY: The Department of Labor's (Department's) Employment and Training Administration proposes...

  19. 76 FR 75561 - Information Collection Request for Unemployment Insurance (UI) Trust Fund Activities Reports...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-02

    ... be provided in the desired format, reporting burden (time and financial resources) is minimized... information deemed necessary to assure state compliance with the provisions of the SSA. Under this authority... deposit and limited withdrawal standards: ETA 2112: UI Financial Transactions Summary, Unemployment...

  20. Effects of population increase on cui-ui growth and maturation

    USGS Publications Warehouse

    Scoppettone, G.G.; Rissler, P.H.

    2007-01-01

    Cui-ui Chasmistes cujus is endemic to Pyramid Lake, Nevada. The cui-ui population declined during much of the 20th century as a result of water diversion and the formation of a shallow and virtually impassable delta at the mouth of the Truckee River, its spawning habitat. The population increased more than 10-fold to more than 1 million adults after access to the river was restored, creating a period of relatively higher density. This change presented the opportunity to test intraspecific density effects on cui-ui age and length at maturity and on growth. We also compared the year-class structure of the adult population before and after improved access. At low density, cui-ui mean age at maturation was 9.2 years for males and 9.6 for females; at high density, it was significantly higher: 11.8 years for males and 12.0 for females. There was no significant change in mean fork length at maturity related to population increase. Growth patterns differed between high and low density, the low-density fish growing faster than high-density fish before their respective mean age of maturity; past their mean age at maturity, high-density fish grew significantly faster than low-density fish. Fish in both density periods reached similar lengths by about 19-20 years of age. Year-class structure for both density periods consisted of strong year-classes, which predominated the adult population for several years.

  1. Attitudes toward Learning about and Working with Computers of Students at UiTM

    ERIC Educational Resources Information Center

    Hashim, Rugayah; Mustapha, Wan Narita

    2004-01-01

    The purpose of this study was to assess the attitudes toward learning about and working with computers of Universiti Teknologi MARA (UiTM), Shah Alam students. Attitudes were studied in an attempt to ascertain factors such as anxiety, confidence, liking and, usefulness at the university level. A total of 300 students at various stages of education…

  2. 77 FR 44678 - Lawson Software, Inc., Including Workers Whose Unemployment Insurance (UI) Wages Were Reported...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-30

    ... (UI) Wages Were Reported Through Lawson Software Americas, Inc. and Infor, Inc., St. Paul, MN..., Tennessee, Texas, Utah, Virginia, Washington, and Wisconsin Reporting to St. Paul, MN; Amended Certification... United States reporting to St. Paul, Minnesota. The Department's notice of determination was published...

  3. Defect-Controlled Preparation of UiO-66 Metal-Organic Framework Thin Films with Molecular Sieving Capability.

    PubMed

    Zhang, Caiqin; Zhao, Yajing; Li, Yali; Zhang, Xuetong; Chi, Lifeng; Lu, Guang

    2016-01-01

    Metal-organic framework (MOF) UiO-66 thin films are solvothermally grown on conducting substrates. The as-synthesized MOF thin films are subsequently dried by a supercritical process or treated with polydimethylsiloxane (PDMS). The obtained UiO-66 thin films show excellent molecular sieving capability as confirmed by the electrochemical studies for redox-active species with different sizes.

  4. Acid-promoted synthesis of UiO-66 for highly selective adsorption of anionic dyes: Adsorption performance and mechanisms.

    PubMed

    Qiu, Jianhao; Feng, Yi; Zhang, Xiongfei; Jia, Mingmin; Yao, Jianfeng

    2017-08-01

    UiO-66 was modulated by addition of acetic acid or HCl in the precursor solution. The resulting acetic acid-promoted UiO-66has more regular octahedral structures and high surface areas of 892-1090m(2)/g. Anionic dyes (methyl orange (MO) and Congo red (CR)) and cationic dyes (methylene blue (MB) and rhodamine B (RhB)) were examined for the selective dye adsorption on various UiO-66. The acid-promoted UiO-66 exhibits an excellent selective adsorption to anionic dyes, where the adsorption capacities of MO and MB are 84.8 and 13.2mg/g, respectively. However, UiO-66 prepared without acid shows similar adsorption to both anionic dye MO (70.4mg/g) and cationic dye MB (67.5mg/g). Mixed dyes (MO/MB and MO/RhB) adsorption on acid-promoted UiO-66 further proves the selective adsorption to anionic dyes. The adsorption mechanism was studied by testing the Zeta potential of acid-promoted UiO-66, and more positive Zeta potential (hydrogen ions) of UiO-66 is beneficial to the anionic dye adsorption. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. 75 FR 51846 - BlueScope Buildings North America Including Workers Whose Unemployment Insurance (UI) Wages Are...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-23

    ... Buildings North America Including Workers Whose Unemployment Insurance (UI) Wages Are Reported Through... wages reported through a separate unemployment insurance (UI) tax account under the name Buttler... as follows: All workers of BlueScope Buildings North America, including workers whose unemployment...

  6. Highly Water-Stable Zirconium Metal-Organic Framework UiO-66 Membranes Supported on Alumina Hollow Fibers for Desalination.

    PubMed

    Liu, Xinlei; Demir, Nilay Keser; Wu, Zhentao; Li, Kang

    2015-06-10

    In this study, continuous zirconium(IV)-based metal-organic framework (Zr-MOF) membranes were prepared. The pure-phase Zr-MOF (i.e., UiO-66) polycrystalline membranes were fabricated on alumina hollow fibers using an in situ solvothermal synthesis method. Single-gas permeation and ion rejection tests were carried out to confirm membrane integrity and functionality. The membrane exhibited excellent multivalent ion rejection (e.g., 86.3% for Ca(2+), 98.0% for Mg(2+), and 99.3% for Al(3+)) on the basis of size exclusion with moderate permeance (0.14 L m(-2) h(-1) bar(-1)) and good permeability (0.28 L m(-2) h(-1) bar(-1) μm). Benefiting from the exceptional chemical stability of the UiO-66 material, no degradation of membrane performance was observed for various tests up to 170 h toward a wide range of saline solutions. The high separation performance combined with its outstanding water stability suggests the developed UiO-66 membrane as a promising candidate for water desalination.

  7. Visualizing K48 Ubiquitination during Presynaptic Formation By Ubiquitination-Induced Fluorescence Complementation (UiFC)

    PubMed Central

    Pinto, Maria J.; Pedro, Joana R.; Costa, Rui O.; Almeida, Ramiro D.

    2016-01-01

    In recent years, signaling through ubiquitin has been shown to be of great importance for normal brain development. Indeed, fluctuations in ubiquitin levels and spontaneous mutations in (de)ubiquitination enzymes greatly perturb synapse formation and neuronal transmission. In the brain, expression of lysine (K) 48-linked ubiquitin chains is higher at a developmental stage coincident with synaptogenesis. Nevertheless, no studies have so far delved into the involvement of this type of polyubiquitin chains in synapse formation. We have recently proposed a role for polyubiquitinated conjugates as triggering signals for presynaptic assembly. Herein, we aimed at characterizing the axonal distribution of K48 polyubiquitin and its dynamics throughout the course of presynaptic formation. To accomplish so, we used an ubiquitination-induced fluorescence complementation (UiFC) strategy for the visualization of K48 polyubiquitin in live hippocampal neurons. We first validated its use in neurons by analyzing changing levels of polyubiquitin. UiFC signal is diffusely distributed with distinct aggregates in somas, dendrites and axons, which perfectly colocalize with staining for a K48-specific antibody. Axonal UiFC aggregates are relatively stable and new aggregates are formed as an axon grows. Approximately 65% of UiFC aggregates colocalize with synaptic vesicle clusters and they preferentially appear in the axonal domains of axo-somatodendritic synapses when compared to isolated axons. We then evaluated axonal accumulation of K48 ubiquitinated signals in bead-induced synapses. We observed rapid accumulation of UiFC signal and endogenous K48 ubiquitin at the sites of newly formed presynapses. Lastly, we show by means of a microfluidic platform, for the isolation of axons, that presynaptic clustering on beads is dependent on E1-mediated ubiquitination at the axonal level. Altogether, these results indicate that enrichment of K48 polyubiquitin at the site of nascent presynaptic

  8. Reproductive longevity and fecundity associated with nonannual spawning in cui-ui

    USGS Publications Warehouse

    Scoppettone, G.G.; Rissler, P.H.; Buettner, M.E.

    2000-01-01

    The cui-ui Chasmistes cujus, a long-lived (40 years or more) and highly fecund catostomid, is often prevented from spawning in drought years. We studied the effect of cui-ui age on egg viability and the effect of nonannual spawning on fecundity in relation to length, age, and growth rate. Egg hatching and survival of swim-up larvae were examined for the offspring of first-time spawners, intermediate-aged females, and old females. Fecundity was tested for three growth categories (fast, intermediate, and slow) in years that were sufficiently wet to allow fish to spawn in the Truckee River and after dry years when fish did not spawn because of river inaccessibility. Females in the fast-growth category were first-time spawners, those in the middle-growth category were young to middle aged, and those in the slow-growth category were middle aged to old. Females up to 44 years of age still had viable eggs and a reproductive life of at least 29 years. Fecundity was greater after no-spawn years (dry year) compared with a spawn year (wet year), especially for fish in the slow-growth category. This study provides insight into the reproductive adaptation of a long-lived western North American catostomid and suggests possible reasons for the wide variation in fecundity in other long-lived catostomids. Our data will be used to improve the accuracy of an existing cui-ui population viability model. The revised model will have greater sensitivity to cui-ui survival relative to their spawning frequency and, thus, contribute to better management of conditions needed for the long-term survival of endangered cui-ui.

  9. Results-Based Interaction Design

    ERIC Educational Resources Information Center

    Weiss, Meredith

    2008-01-01

    Interaction design is a user-centered approach to development in which users and their goals are the driving force behind a project's design. Interaction design principles are fundamental to the design and implementation of effective websites, but they are not sufficient. This article argues that, to reach its full potential, a website should also…

  10. Results-Based Interaction Design

    ERIC Educational Resources Information Center

    Weiss, Meredith

    2008-01-01

    Interaction design is a user-centered approach to development in which users and their goals are the driving force behind a project's design. Interaction design principles are fundamental to the design and implementation of effective websites, but they are not sufficient. This article argues that, to reach its full potential, a website should also…

  11. A Discussion of Knowledge Based Design

    NASA Technical Reports Server (NTRS)

    Wood, Richard M.; Bauer, Steven X. S.

    1999-01-01

    A discussion of knowledge and Knowledge- Based design as related to the design of aircraft is presented. The paper discusses the perceived problem with existing design studies and introduces the concepts of design and knowledge for a Knowledge- Based design system. A review of several Knowledge-Based design activities is provided. A Virtual Reality, Knowledge-Based system is proposed and reviewed. The feasibility of Virtual Reality to improve the efficiency and effectiveness of aerodynamic and multidisciplinary design, evaluation, and analysis of aircraft through the coupling of virtual reality technology and a Knowledge-Based design system is also reviewed. The final section of the paper discusses future directions for design and the role of Knowledge-Based design.

  12. Designer: A Knowledge-Based Graphic Design Assistant.

    ERIC Educational Resources Information Center

    Weitzman, Louis

    This report describes Designer, an interactive tool for assisting with the design of two-dimensional graphic interfaces for instructional systems. The system, which consists of a color graphics interface to a mathematical simulation, provides enhancements to the Graphics Editor component of Steamer (a computer-based training system designed to aid…

  13. Designer: A Knowledge-Based Graphic Design Assistant.

    ERIC Educational Resources Information Center

    Weitzman, Louis

    This report describes Designer, an interactive tool for assisting with the design of two-dimensional graphic interfaces for instructional systems. The system, which consists of a color graphics interface to a mathematical simulation, provides enhancements to the Graphics Editor component of Steamer (a computer-based training system designed to aid…

  14. Team Based Engineering Design Thinking

    ERIC Educational Resources Information Center

    Mentzer, Nathan

    2012-01-01

    The objective of this research was to explore design thinking among teams of high school students. This objective is encompassed in the research question driving this inquiry: How do teams of high school students allocate time across stages of design? Design thinking on the professional level typically occurs in a team environment. Many…

  15. Team Based Engineering Design Thinking

    ERIC Educational Resources Information Center

    Mentzer, Nathan

    2014-01-01

    The objective of this research was to explore design thinking among teams of high school students. This objective was encompassed in the research question driving the inquiry: How do teams of high school students allocate time across stages of design? Design thinking on the professional level typically occurs in a team environment. Many…

  16. Fine Mapping of ui6.1, a Gametophytic Factor Controlling Pollen-Side Unilateral Incompatibility in Interspecific Solanum Hybrids

    PubMed Central

    Li, Wentao; Royer, Suzanne; Chetelat, Roger T.

    2010-01-01

    Unilateral incompatibility (UI) is a prezygotic reproductive barrier in plants that prevents fertilization by foreign (interspecific) pollen through the inhibition of pollen tube growth. Incompatibility occurs in one direction only, most often when the female is a self-incompatible species and the male is self-compatible (the “SI × SC rule”). Pistils of the wild tomato relative Solanum lycopersicoides (SI) reject pollen of cultivated tomato (S. lycopersicum, SC), but accept pollen of S. pennellii (SC accession). Expression of pistil-side UI is weakened in S. lycopersicum × S. lycopersicoides hybrids, as pollen tube rejection occurs lower in the style. Two gametophytic factors are sufficient for pollen compatibility on allotriploid hybrids: ui1.1 on chromosome 1 (near the S locus), and ui6.1 on chromosome 6. We report herein a fine-scale map of the ui6.1 region. Recombination around ui6.1 was suppressed in lines containing a short S. pennellii introgression, but less so in lines containing a longer introgression. More recombinants were obtained from female than male meioses. A high-resolution genetic map of this region delineated the location of ui6.1 to ∼0.128 MU, or 160 kb. Identification of the underlying gene should elucidate the mechanism of interspecific pollen rejection and its relationship to self-incompatibility. PMID:20439771

  17. Assessment of the Plasmodium falciparum Preerythrocytic Antigen UIS3 as a Potential Candidate for a Malaria Vaccine

    PubMed Central

    Halbroth, Benedict R.; Salman, Ahmed M.; Ewer, Katie J.; Hodgson, Susanne H.; Janse, Chris J.; Khan, Shahid M.; Hill, Adrian V. S.; Spencer, Alexandra J.

    2016-01-01

    ABSTRACT Efforts are under way to improve the efficacy of subunit malaria vaccines through assessments of new adjuvants, vaccination platforms, and antigens. In this study, we further assessed the Plasmodium falciparum antigen upregulated in infective sporozoites 3 (PfUIS3) as a vaccine candidate. PfUIS3 was expressed in the viral vectors chimpanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) and used to immunize mice in a prime-boost regimen. We previously demonstrated that this regimen could provide partial protection against challenge with chimeric P. berghei parasites expressing PfUIS3. We now show that ChAd63-MVA PfUIS3 can also provide partial cross-species protection against challenge with wild-type P. berghei parasites. We also show that PfUIS3-specific cellular memory responses could be recalled in human volunteers exposed to P. falciparum parasites in a controlled human malaria infection study. When ChAd63-MVA PfUIS3 was coadministered with the vaccine candidate P. falciparum thrombospondin-related adhesion protein (PfTRAP) expressed in the ChAd63-MVA system, there was no significant change in immunogenicity to either vaccine. However, when mice were challenged with double chimeric P. berghei-P. falciparum parasites expressing both PfUIS3 and PfTRAP, vaccine efficacy was improved to 100% sterile protection. This synergistic effect was evident only when the two vaccines were mixed and administered at the same site. We have therefore demonstrated that vaccination with PfUIS3 can induce a consistent delay in patent parasitemia across mouse strains and against chimeric parasites expressing PfUIS3 as well as wild-type P. berghei; when this vaccine is combined with another partially protective regimen (ChAd63-MVA PfTRAP), complete protection is induced. PMID:28031267

  18. 20 CFR 652.210 - What are the Act's requirements for administration of the work test and assistance to UI claimants?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... administration of the work test and assistance to UI claimants? 652.210 Section 652.210 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR ESTABLISHMENT AND FUNCTIONING OF STATE EMPLOYMENT... requirements for administration of the work test and assistance to UI claimants? (a) State UI law or rules...

  19. Preparation, characterization, and performance evaluation of UiO-66 analogues as stationary phase in HPLC for the separation of substituted benzenes and polycyclic aromatic hydrocarbons

    PubMed Central

    Yan, Zengguang; Li, Jianrong; Xie, Yabo; Bai, Liping; Jiang, Lin; Li, Fasheng

    2017-01-01

    UiO-66 analogues are good candidates as stationary phase in HPLC because of their chemical/thermal stability, large surface area, and two cage structures. Here, two UiO-66 analogues, UiO-66-NH2 and UiO-67, were synthesized and used as stationary phase in HPLC to evaluate their performance in the separation of substituted benzenes (SBs) and polycyclic aromatic hydrocarbons (PAHs). The results showed that SBs could be well separated on UiO-66-NH2 column but not on UiO-67 column. Nonetheless, PAHs could be well separated on UiO-67 column. The separation mechanisms of SBs and PAHs on UiO-66 analogues may be involved in the pore size and functional group in the frameworks of UiO-66 analogues. Introduction of the–NH2 into UiO-66 significantly reduced its adsorption capacity for SB congeners, which resulted in less separation of SBs on UiO-66-NH2. As for the separation of PAHs on UiO-67 column, the π-π stacking effect was supposed to play a vital role. PMID:28582453

  20. Scheduling bus services in Universiti Teknologi MARA (UiTM) Shah Alam

    NASA Astrophysics Data System (ADS)

    Omar, Mawardi; Ismail, Wan Rosmanira; Oughalime, Ahmed

    2014-09-01

    This study deals with bus scheduling problem in a local public university. Given existing bus daily trips, set of buses used and set of policy, the aims of this study are to optimize the use of buses for in-campus trips and to cover the trip demands. This study is conducted at Universiti Teknologi Mara (UiTM) Shah Alam that involves six-zone trips and a single depot. The bus scheduling problem in UiTM is formulated using the integer programming model and the LINGO 12.0 software is used for solving this bus scheduling model. The results of this model showed that the number of buses can be reduced during off-peak hours. Furthermore, optimal trips can also be identified from the results.

  1. Superior removal of arsenic from water with zirconium metal-organic framework UiO-66.

    PubMed

    Wang, Chenghong; Liu, Xinlei; Chen, J Paul; Li, Kang

    2015-11-12

    In this study, water stable zirconium metal-organic framework (UiO-66) has been synthesized and for the first time applied as an adsorbent to remove aquatic arsenic contamination. The as-synthesized UiO-66 adsorbent functions excellently across a broad pH range of 1 to 10, and achieves a remarkable arsenate uptake capacity of 303 mg/g at the optimal pH, i.e., pH = 2. To the best of our knowledge, this is the highest arsenate As(V) adsorption capacity ever reported, much higher than that of currently available adsorbents (5-280 mg/g, generally less than 100 mg/g). The superior arsenic uptake performance of UiO-66 adsorbent could be attributed to the highly porous crystalline structure containing zirconium oxide clusters, which provides a large contact area and plenty of active sites in unit space. Two binding sites within the adsorbent framework are proposed for arsenic species, i.e., hydroxyl group and benzenedicarboxylate ligand. At equilibrium, seven equivalent arsenic species can be captured by one Zr6 cluster through the formation of Zr-O-As coordination bonds.

  2. Reproduction by the endangered cui-ui in the lower Truckee River

    USGS Publications Warehouse

    Scoppettone, G.G.; Wedemeyer, G.A.; Coleman, M.; Burge, H.

    1983-01-01

    Adult spawning behavior and emigration of larvae of the endangered cui-ui Chasmistes cujus were studied in a natural side channel of the lower Truckee River. External radio-tags placed on eight apparently did not affect spawning behavior. Cui-uis spawned in clusters of two to seven fish; usually a single female was flanked by two males. Each spawning act lasted 3–6 seconds, and individual fish spawned numerous times. The most active tagged male and female spawned at least 294 times and 114 times, respectively. Individual females broadcast eggs over an area of up to 50 m2. Males spawned over a 4–5-day period, and females over 2.5–4 days. Most spawning occurred at night in water depths ranging from 9 to 43 cm, water velocities ranging from 23 to 87 cm/second, and temperatures of 12–17 C. The preferred spawning substrate was gravel. Peak emergence and out-migration of cui-ui larvae occurred 14 days after peak spawning.

  3. RAY-UI: A powerful and extensible user interface for RAY

    SciTech Connect

    Baumgärtel, P. Erko, A.; Schäfers, F.; Witt, M.; Baensch, J.; Fabarius, M.; Schirmacher, H.

    2016-07-27

    The RAY-UI project started as a proof-of-concept for an interactive and graphical user interface (UI) for the well-known ray tracing software RAY [1]. In the meantime, it has evolved into a powerful enhanced version of RAY that will serve as the platform for future development and improvement of associated tools. The software as of today supports nearly all sophisticated simulation features of RAY. Furthermore, it delivers very significant usability and work efficiency improvements. Beamline elements can be quickly added or removed in the interactive sequence view. Parameters of any selected element can be accessed directly and in arbitrary order. With a single click, parameter changes can be tested and new simulation results can be obtained. All analysis results can be explored interactively right after ray tracing by means of powerful integrated image viewing and graphing tools. Unlimited image planes can be positioned anywhere in the beamline, and bundles of image planes can be created for moving the plane along the beam to identify the focus position with live updates of the simulated results. In addition to showing the features and workflow of RAY-UI, we will give an overview of the underlying software architecture as well as examples for use and an outlook for future developments.

  4. Superior removal of arsenic from water with zirconium metal-organic framework UiO-66

    PubMed Central

    Wang, Chenghong; Liu, Xinlei; Chen, J. Paul; Li, Kang

    2015-01-01

    In this study, water stable zirconium metal-organic framework (UiO-66) has been synthesized and for the first time applied as an adsorbent to remove aquatic arsenic contamination. The as-synthesized UiO-66 adsorbent functions excellently across a broad pH range of 1 to 10, and achieves a remarkable arsenate uptake capacity of 303 mg/g at the optimal pH, i.e., pH = 2. To the best of our knowledge, this is the highest arsenate As(V) adsorption capacity ever reported, much higher than that of currently available adsorbents (5–280 mg/g, generally less than 100 mg/g). The superior arsenic uptake performance of UiO-66 adsorbent could be attributed to the highly porous crystalline structure containing zirconium oxide clusters, which provides a large contact area and plenty of active sites in unit space. Two binding sites within the adsorbent framework are proposed for arsenic species, i.e., hydroxyl group and benzenedicarboxylate ligand. At equilibrium, seven equivalent arsenic species can be captured by one Zr6 cluster through the formation of Zr-O-As coordination bonds. PMID:26559001

  5. Research on optimization-based design

    NASA Technical Reports Server (NTRS)

    Balling, R. J.; Parkinson, A. R.; Free, J. C.

    1989-01-01

    Research on optimization-based design is discussed. Illustrative examples are given for cases involving continuous optimization with discrete variables and optimization with tolerances. Approximation of computationally expensive and noisy functions, electromechanical actuator/control system design using decomposition and application of knowledge-based systems and optimization for the design of a valve anti-cavitation device are among the topics covered.

  6. Population-Based Survey on Disease Insight, Quality of Life, and Health-Seeking Behavior Associated With Female Urinary Incontinence

    PubMed Central

    Choi, Hoon; Park, Jae Young; Yeo, Jeong Kyun; Oh, Mi Mi; Moon, Du Geon; Lee, Jeong Gu; Bae, Jae Hyun

    2015-01-01

    Purpose: To evaluate disease insight, personal distress, and healthcare-seeking behavior of women with urinary incontinence (UI) to improve women’s health in Korea. Methods: In October 2012, 500 Korean women residing around Seoul, Incheon, and Gyeonggi-do were selected by random sampling for a population-based cross-sectional survey conducted by computer-aided telephone interview. Sixteen questions, which included information on demographic characteristics, information sources, disease insights, and general health-seeking behavior, were used for data collection. Results: Among the responders, 23.8% experienced UI, the prevalence of which increased with increasing age; 83.3% knew about UI through the mass media out of 98.2% apprehended people. Regarding general awareness of UI, 77.2% understood that UI is caused by aging. A total of 48.7% of subjects experienced societal restrictions because of UI. Most women in their 30s (25.6%) acquired UI information from the Internet, while those in their 50s and 60s (50–59 years, 51.1%; 60–64 years, 42.4%) learned about UI through friends. Among subjects who did not have UI, 89.37% intended to see a doctor or consult a professional if they developed UI (83.2%). Among those with UI, however, only 59.0% had talked about UI; 79.7% had talked with friends or associates, whereas only 23.2% had consulted a professional. Conclusions: Most respondents tended to obtain information on UI through the mass media. Subjects who did not have UI expressed their intention to consult a professional if they developed UI, while the percentage of subjects with UI who had consulted a professional was very low. Many women are ashamed of UI in Korea, which may be changed by providing efficient advertising with the right information and establishing a new perception of UI. PMID:25833480

  7. Reliability based design optimization: Formulations and methodologies

    NASA Astrophysics Data System (ADS)

    Agarwal, Harish

    Modern products ranging from simple components to complex systems should be designed to be optimal and reliable. The challenge of modern engineering is to ensure that manufacturing costs are reduced and design cycle times are minimized while achieving requirements for performance and reliability. If the market for the product is competitive, improved quality and reliability can generate very strong competitive advantages. Simulation based design plays an important role in designing almost any kind of automotive, aerospace, and consumer products under these competitive conditions. Single discipline simulations used for analysis are being coupled together to create complex coupled simulation tools. This investigation focuses on the development of efficient and robust methodologies for reliability based design optimization in a simulation based design environment. Original contributions of this research are the development of a novel efficient and robust unilevel methodology for reliability based design optimization, the development of an innovative decoupled reliability based design optimization methodology, the application of homotopy techniques in unilevel reliability based design optimization methodology, and the development of a new framework for reliability based design optimization under epistemic uncertainty. The unilevel methodology for reliability based design optimization is shown to be mathematically equivalent to the traditional nested formulation. Numerical test problems show that the unilevel methodology can reduce computational cost by at least 50% as compared to the nested approach. The decoupled reliability based design optimization methodology is an approximate technique to obtain consistent reliable designs at lesser computational expense. Test problems show that the methodology is computationally efficient compared to the nested approach. A framework for performing reliability based design optimization under epistemic uncertainty is also developed

  8. MOFabric: Electrospun Nanofiber Mats from PVDF/UiO-66-NH2 for Chemical Protection and Decontamination.

    PubMed

    Lu, Annie Xi; McEntee, Monica; Browe, Matthew A; Hall, Morgan G; DeCoste, Jared B; Peterson, Gregory W

    2017-04-19

    Textiles capable of capture and detoxification of toxic chemicals, such as chemical-warfare agents (CWAs), are of high interest. Some metal-organic frameworks (MOFs) exhibit superior reactivity toward CWAs. However, it remains a challenge to integrate powder MOFs into engineered materials like textiles, while retaining functionalities like crystallinity, adsorptivity, and reactivity. Here, we present a simple method of electrospinning UiO-66-NH2, a zirconium MOF, with polyvinylidene fluoride (PVDF). The electrospun composite, which we refer to as "MOFabric", exhibits comparable crystal patterns, surface area, chlorine uptake, and simulant hydrolysis to powder UiO-66-NH2. The MOFabric is also capable of breaking down GD (O-pinacolyl methylphosphonofluoridae) faster than powder UiO-66-NH2. Half-life of GD monitored by solid-state NMR for MOFabric is 131 min versus 315 min on powder UiO-66-NH2.

  9. PMIS: Data Base Design Report

    ERIC Educational Resources Information Center

    Fiddleman, Richard; Gorman, Michael M.

    1972-01-01

    PMIS is a computer-based planning and management information system for local school districts. This report centers on the PMIS data bases that contain school system data by reviewing the major phases involved in their creation, explaining the factors that caused the unique orientation of the data bases, reviewing the two tasks that comprise the…

  10. Towards structure-based protein drug design.

    PubMed

    Zhang, Changsheng; Lai, Luhua

    2011-10-01

    Structure-based drug design for chemical molecules has been widely used in drug discovery in the last 30 years. Many successful applications have been reported, especially in the field of virtual screening based on molecular docking. Recently, there has been much progress in fragment-based as well as de novo drug discovery. As many protein-protein interactions can be used as key targets for drug design, one of the solutions is to design protein drugs based directly on the protein complexes or the target structure. Compared with protein-ligand interactions, protein-protein interactions are more complicated and present more challenges for design. Over the last decade, both sampling efficiency and scoring accuracy of protein-protein docking have increased significantly. We have developed several strategies for structure-based protein drug design. A grafting strategy for key interaction residues has been developed and successfully applied in designing erythropoietin receptor-binding proteins. Similarly to small-molecule design, we also tested de novo protein-binder design and a virtual screen of protein binders using protein-protein docking calculations. In comparison with the development of structure-based small-molecule drug design, we believe that structure-based protein drug design has come of age.

  11. Design versus manufacturing data base management requirements

    NASA Technical Reports Server (NTRS)

    Mckenna, E. G.

    1984-01-01

    Data base management systems are valuable manufacturing and design tools as these disciplines are exceptionally information intensive, requiring precise organization and control of data processing and utilization. One such data base manager is the IPAD* system, which was originally developed to support the design process but was expanded to incorporate the additional needs of manufacturing. To set the stage, an overview of the design and manufacturing process is presented. The different functions of computers in these processes are then discussed. Finally, the design and manufacturing requirements for a data base manager are compared and contrasted.

  12. Observations from the Microgravity Smoldering Combustion (MSC) Ultrasound Imaging System (UIS)

    NASA Technical Reports Server (NTRS)

    Walther, D.C.; Fernandez-Pello, A. C.; Anthenien, R. A.; Urban, D. L.

    1999-01-01

    The Microgravity Smoldering Combustion (MSC) experiment is a study of the smolder characteristics of porous combustible materials in a microgravity environment. The objective of the study is to provide a better understanding of the controlling mechanisms of smolder, both in microgravity and normal earth gravity. Experiments have been conducted aboard the NASA Space Shuttle in the GAS-CAN, an apparatus requiring completely remote operation. Future GAS-CAN experiments will utilize an ultrasound imaging system (UIS). Thermocouples are currently used to measure temperature and reaction front velocities, but a less intrusive method is desirable, as smolder is affected by heat transfer along the thermocouple. It is expected that the UIS will eventually replace the existing array of thermocouples as a non-intrusive technique without compromising data acquisition. Smoldering is defined as a non-flaming, self-sustaining, propagating, exothermic, surface reaction, deriving its principal heat from heterogeneous oxidation of the fuel. Smolder of cable insulation is of particular concern in the space program; to date there have been a few minor incidents of overheated and charred cables and electrical components reported on Space Shuttle flights. Recently, the establishment of the International Space Station and other space facilities has increased interest in the study of smoldering in microgravity because of the need to preempt the possibility, and/or to minimize the effect of a smolder initiated fire during the operation of these facilities. The ignition and propagation of smolder are examined using both thermocouples and the UIS. The UIS has been implemented into the MSC flight hardware. The system provides information about local permeability variations within a smoldering sample, which can, in turn, be interpreted to track the propagation of the smolder reaction. The method utilizes the observation that transmission of an ultrasonic signal through a porous material

  13. Separations of substituted benzenes and polycyclic aromatic hydrocarbons using normal- and reverse-phase high performance liquid chromatography with UiO-66 as the stationary phase.

    PubMed

    Zhao, Wei-Wei; Zhang, Chao-Yan; Yan, Zeng-Guang; Bai, Li-Ping; Wang, Xiayan; Huang, Hongliang; Zhou, You-Ya; Xie, Yabo; Li, Fa-Sheng; Li, Jian-Rong

    2014-11-28

    Metal-organic frameworks (MOFs) have great potential for applications in chromatography due to their highly tailorable porous structures and unique properties. In this work, the stable MOF UiO-66 was evaluated as both a normal-phase (NP-) and a reverse-phase (RP-) stationary phase in the high performance liquid chromatography (HPLC) to separate substituted benzenes (SBs) and polycyclic aromatic hydrocarbons (PAHs). It was found that the mobile phase composition has a significant effect on the HPLC separation. Baseline RP-HPLC separations of xylene isomers; naphthalene and anthracene; naphthalene and chrysene; and naphthalene, fluorene, and chrysene were achieved using MeOH/H2O ratios of 80:20, 75:25, 85:15, and 75:25, respectively, on the UiO-66 column. Similarly, baseline NP-HPLC separations of xylene isomers and ethylbenzene; ethylbenzene, styrene, o-xylene, and m-xylene; and several PAHs were also obtained on the UiO-66 column with different mobile phase compositions. The relative standard deviations (RSDs) of retention time, peak height, peak area, and half peak width for five replicate separations of the tested analytes were within the ranges 0.2-0.4%, 0.2-1.6%, 0.7-3.9%, 0.4-1.1%, respectively. We also evaluated other critical HPLC parameters, including injected sample mass, column temperature, and the thermodynamic characters of both the RP-HPLC and the NP-HPLC separation processes. It was confirmed that the separation of SBs on a UiO-66 column was an exothermic process, controlled by both enthalpy change (ΔH) and entropy change (ΔS). The reverse shape selectivity, size selectivity, stacking effect, and electrostatic force played vital roles in the separations of these analytes. To the best of our knowledge, this method is one of the very few examples of using MOFs as the stationary phase in both NP-HPLC and RP-HPLC. MOF-based stationary phases may thus be applied in the separations and analyses of SBs and PAHs in environmental samples.

  14. Multidisciplinary Expert-aided Analysis and Design (MEAD)

    NASA Technical Reports Server (NTRS)

    Hummel, Thomas C.; Taylor, James

    1989-01-01

    The MEAD Computer Program (MCP) is being developed under the Multidisciplinary Expert-Aided Analysis and Design (MEAD) Project as a CAD environment in which integrated flight, propulsion, and structural control systems can be designed and analyzed. The MCP has several embedded computer-aided control engineering (CACE) packages, a user interface (UI), a supervisor, a data-base manager (DBM), and an expert system (ES). The supervisor monitors and coordinates the operation of the CACE packages, the DBM; the ES, and the UI. The DBM tracks the control design process. Models created or installed by the MCP are tracked by date and version, and results are associated with the specific model version with which they were generated. The ES is used to relieve the control engineer from tedious and cumbersome tasks in the iterative design process. The UI provides the capability for a novice as well as an expert to utilize the MCP easily and effectively. The MCP version 2(MCP-2.0) is fully developed for flight control system design and analysis. Propulsion system modeling, analysis, and simulation is also supported; the same is true for structural models represented in state-space form. The ultimate goal is to cover the integration of flight, propulsion, and structural control engineering, including all discipline-specific functionality and interfaces. The current MCP-2.0 components and functionality are discussed.

  15. Towards Risk Based Design for NASA's Missions

    NASA Technical Reports Server (NTRS)

    Tumer, Irem Y.; Barrientos, Francesca; Meshkat, Leila

    2004-01-01

    This paper describes the concept of Risk Based Design in the context of NASA s low volume, high cost missions. The concept of accounting for risk in the design lifecycle has been discussed and proposed under several research topics, including reliability, risk analysis, optimization, uncertainty, decision-based design, and robust design. This work aims to identify and develop methods to enable and automate a means to characterize and optimize risk, and use risk as a tradeable resource to make robust and reliable decisions, in the context of the uncertain and ambiguous stage of early conceptual design. This paper first presents a survey of the related topics explored in the design research community as they relate to risk based design. Then, a summary of the topics from the NASA-led Risk Colloquium is presented, followed by current efforts within NASA to account for risk in early design. Finally, a list of "risk elements", identified for early-phase conceptual design at NASA, is presented. The purpose is to lay the foundation and develop a roadmap for future work and collaborations for research to eliminate and mitigate these risk elements in early phase design.

  16. Evidence-Based Design and Research-Informed Design.

    PubMed

    Peavey, Erin; Vander Wyst, Kiley B

    2017-01-01

    This article provides critical examination and comparison of the conceptual meaning and underlying assumptions of the concepts evidence-based design (EBD) and research-informed design (RID) in order to facilitate practical use and theoretical development. In recent years, EBD has experienced broad adoption, yet it has been simultaneously critiqued for rigidity and misapplication. Many practitioners are gravitating to the term RID to describe their method of integrating knowledge into the design process. However, the term RID lacks a clear definition and the blurring of terms has the potential to weaken advances made integrating research into practice. Concept analysis methods from Walker and Avant were used to define the concepts for comparison. Conceptual definitions, process descriptions, examples (i.e., model cases), and methods of evaluation are offered for EBD and RID. Although EBD and RID share similarities in meaning, the two terms are distinct. When comparing evidence based (EB) and research informed, EB is a broad base of information types (evidence) that are narrowly applied (based), while the latter references a narrow slice of information (research) that is broadly applied (informed) to create an end product of design. Much of the confusion between the use of the concepts EBD and RID arises out of differing perspectives between the way practitioners and academics understand the underlying terms. The authors hope this article serves to generate thoughtful dialogue, which is essential to the development of a discipline, and look forward to the contribution of the readership.

  17. A rule based computer aided design system

    NASA Technical Reports Server (NTRS)

    Premack, T.

    1986-01-01

    A Computer Aided Design (CAD) system is presented which supports the iterative process of design, the dimensional continuity between mating parts, and the hierarchical structure of the parts in their assembled configuration. Prolog, an interactive logic programming language, is used to represent and interpret the data base. The solid geometry representing the parts is defined in parameterized form using the swept volume method. The system is demonstrated with a design of a spring piston.

  18. Design for validation, based on formal methods

    NASA Technical Reports Server (NTRS)

    Butler, Ricky W.

    1990-01-01

    Validation of ultra-reliable systems decomposes into two subproblems: (1) quantification of probability of system failure due to physical failure; (2) establishing that Design Errors are not present. Methods of design, testing, and analysis of ultra-reliable software are discussed. It is concluded that a design-for-validation based on formal methods is needed for the digital flight control systems problem, and also that formal methods will play a major role in the development of future high reliability digital systems.

  19. Optimization-based controller design for rotorcraft

    NASA Technical Reports Server (NTRS)

    Tsing, N.-K.; Fan, M. K. H.; Barlow, J.; Tits, A. L.; Tischler, M. B.

    1993-01-01

    An optimization-based methodology for linear control system design is outlined by considering the design of a controller for a UH-60 rotorcraft in hover. A wide range of design specifications is taken into account: internal stability, decoupling between longitudinal and lateral motions, handling qualities, and rejection of windgusts. These specifications are investigated while taking into account physical limitations in the swashplate displacements and rates of displacement. The methodology crucially relies on user-machine interaction for tradeoff exploration.

  20. Advances in Design-Based Research

    ERIC Educational Resources Information Center

    Svihla, Vanessa

    2014-01-01

    Design-based research (DBR) is a core methodology of the Learning Sciences. Historically rooted as a movement away from the methods of experimental psychology, it is a means to develop "humble" theory that takes into account numerous contextual effects for understanding how and why a design supported learning. DBR involves iterative…

  1. Web-Based Learning Design Tool

    ERIC Educational Resources Information Center

    Bruno, F. B.; Silva, T. L. K.; Silva, R. P.; Teixeira, F. G.

    2012-01-01

    Purpose: The purpose of this paper is to propose a web-based tool that enables the development and provision of learning designs and its reuse and re-contextualization as generative learning objects, aimed at developing educational materials. Design/methodology/approach: The use of learning objects can facilitate the process of production and…

  2. Web-Based Learning Design Tool

    ERIC Educational Resources Information Center

    Bruno, F. B.; Silva, T. L. K.; Silva, R. P.; Teixeira, F. G.

    2012-01-01

    Purpose: The purpose of this paper is to propose a web-based tool that enables the development and provision of learning designs and its reuse and re-contextualization as generative learning objects, aimed at developing educational materials. Design/methodology/approach: The use of learning objects can facilitate the process of production and…

  3. Thermodynamic Insight in the High-Pressure Behavior of UiO-66: Effect of Linker Defects and Linker Expansion

    PubMed Central

    2016-01-01

    In this Article, we present a molecular-level understanding of the experimentally observed loss of crystallinity in UiO-66-type metal–organic frameworks, including the pristine UiO-66 to -68 as well as defect-containing UiO-66 materials, under the influence of external pressure. This goal is achieved by constructing pressure-versus-volume profiles at finite temperatures using a thermodynamic approach relying on ab initio derived force fields. On the atomic level, the phenomenon is reflected in a sudden drop in the number of symmetry operators for the crystallographic unit cell because of the disordered displacement of the organic linkers with respect to the inorganic bricks. For the defect-containing samples, a reduced mechanical stability is observed, however, critically depending on the distribution of these defects throughout the material, hence demonstrating the importance of judiciously characterizing defects in these materials. PMID:27594765

  4. Error-Based Design Space Windowing

    NASA Technical Reports Server (NTRS)

    Papila, Melih; Papila, Nilay U.; Shyy, Wei; Haftka, Raphael T.; Fitz-Coy, Norman

    2002-01-01

    Windowing of design space is considered in order to reduce the bias errors due to low-order polynomial response surfaces (RS). Standard design space windowing (DSW) uses a region of interest by setting a requirement on response level and checks it by a global RS predictions over the design space. This approach, however, is vulnerable since RS modeling errors may lead to the wrong region to zoom on. The approach is modified by introducing an eigenvalue error measure based on point-to-point mean squared error criterion. Two examples are presented to demonstrate the benefit of the error-based DSW.

  5. A knowledge-based approach to design

    NASA Astrophysics Data System (ADS)

    Mitchell, T. M.; Steinberg, L. I.; Shulman, J. S.

    1985-09-01

    The potential advantages of knowledge-based methods for computer-aided design are examined, and the organization of VEXED, a knowledge-based system for VLSI design, is described in detail. In particular, attention is given to the principles underlying the design of VEXED and several issues that have arisen from implementing and experimenting with the prototype system. The issues discussed include questions regarding the grainsize of rules, the possibility of learning new rules automatically, and issues related to constraint propagation and management.

  6. Population dynamics of the Cui-ui of Pyramid Lake, Nevada: a Potamodromous catostomid subject to failed reproduction

    USGS Publications Warehouse

    Scoppettone, Gayton G.; Rissler, Peter H.; Fabes, Mark C.; Shea, Sean P.

    2015-01-01

    Fishes of the Truckee River basin (California and Nevada) evolved in an aquatic system that has been episodically diminished by extended drought. For potamodromous species, such as the endangered Cui-ui endemic to Pyramid Lake, Nevada, prehistoric episodic severe drought presumably led to periods of failed reproduction due to restricted access to spawning habitat. The response of the Cui-ui population to more recent failed reproduction caused by anthropogenic activity was studied to learn how to manage this species through periods of spawning disruption. Adult Cui-ui survival averaged 91% and 89% for females and males, respectively, in drought years when spawning migrations were either precluded or few fish migrated because of no or low stream flow. In each of 2 years when stream access was precluded, the adult survival was nearly 100% suggesting that Cui-ui survival is extended in the absence of a spawning migration. Survival averaged 62% and 60% for females and males, respectively, in years of spawning migrations. Strong predominant year-classes developed in the year immediately following a period of failed reproduction, indicating the species’ capacity for population rebound. Year-class predominance persisted for 6–10 years and through years of low survival associated with migration years, and this predominance is probably due, in part, to a diverse age at maturity. Contemporary water diversions from the Truckee River provided the opportunity to study the response of the Cui-ui population to years of failed reproduction. A projected drier Truckee River basin associated with global climate change will test the Cui-ui’s adaptive capacity to endure periods of reproductive failure. This study is aimed at assisting Cui-ui managers in conserving the species in this highly regulated and changing system. The study also adds insight into the prehistoric population dynamics of a potamodromous species in the arid western United States subject to wide fluctuations in

  7. Assembly design system based on engineering connection

    NASA Astrophysics Data System (ADS)

    Yin, Wensheng

    2016-12-01

    An assembly design system is an important part of computer-aided design systems, which are important tools for realizing product concept design. The traditional assembly design system does not record the connection information of production on the engineering layer; consequently, the upstream design idea cannot be fully used in the downstream design. An assembly design model based on the relationship of engineering connection is presented. In this model, all nodes are divided into two categories: The component and the connection. Moreover, the product is constructed on the basis of the connection relationship of the components. The model is an And/Or graph and has the ability to record all assembly schemes. This model records only the connection information that has engineering application value in the product design. In addition, this model can significantly reduce the number of combinations, and is very favorable for the assembly sequence planning in the downstream. The system contains a connection knowledge system that can be mapped to the connection node, and the connection knowledge obtained in practice can be returned to the knowledge system. Finally, VC++ 6.0 is used to develop a prototype system called Connect-based Assembly Planning (CAP). The relationship between the CAP system and the commercial assembly design system is also established.

  8. Design and designability of protein-based assemblies.

    PubMed

    Zhang, Jian; Zheng, Fan; Grigoryan, Gevorg

    2014-08-01

    Design of protein-based assemblies is an exciting frontier in molecular engineering. It can be seen as an extension of the protein design problem, but with some added hurdles. In recent years, much of the focus in the field has been on patterning existing protein structural units (proteins, oligomers, or structural motifs) to design diverse assembly geometries, focusing on symmetry to encode both "infinite" lattices and finite-sized supramolecular particles. Despite impressive successes, several key challenges remain. Among these are the specificity problem the need to engineer preference for the intended assembly geometry over all alternatives, and the folding problem--understanding what thermodynamic or kinetic features of assembly subunits and inter-subunit interfaces lead to successfully folding superstructures and how to encode these in the amino-acid sequence. Here we focus on recent results in the context of these two problems, summarizing commonalities in successful approaches. We find that natural designability of assembly elements (i.e., their compatibility with diverse populations of natural amino-acid sequences) may be a unifying property of successful designs.

  9. Evidence for a chemical clock in oscillatory formation of UiO-66.

    PubMed

    Goesten, M G; de Lange, M F; Olivos-Suarez, A I; Bavykina, A V; Serra-Crespo, P; Krywka, C; Bickelhaupt, F M; Kapteijn, F; Gascon, Jorge

    2016-06-10

    Chemical clocks are often used as exciting classroom experiments, where an induction time is followed by rapidly changing colours that expose oscillating concentration patterns. This type of reaction belongs to a class of nonlinear chemical kinetics also linked to chaos, wave propagation and Turing patterns. Despite its vastness in occurrence and applicability, the clock reaction is only well understood for liquid-state processes. Here we report a chemical clock reaction, in which a solidifying entity, metal-organic framework UiO-66, displays oscillations in crystal dimension and number, as shown by X-ray scattering. In rationalizing this result, we introduce a computational approach, the metal-organic molecular orbital methodology, to pinpoint interaction between the tectonic building blocks that construct the metal-organic framework material. In this way, we show that hydrochloric acid plays the role of autocatalyst, bridging separate processes of condensation and crystallization.

  10. Evidence for a chemical clock in oscillatory formation of UiO-66

    NASA Astrophysics Data System (ADS)

    Goesten, M. G.; de Lange, M. F.; Olivos-Suarez, A. I.; Bavykina, A. V.; Serra-Crespo, P.; Krywka, C.; Bickelhaupt, F. M.; Kapteijn, F.; Gascon, Jorge

    2016-06-01

    Chemical clocks are often used as exciting classroom experiments, where an induction time is followed by rapidly changing colours that expose oscillating concentration patterns. This type of reaction belongs to a class of nonlinear chemical kinetics also linked to chaos, wave propagation and Turing patterns. Despite its vastness in occurrence and applicability, the clock reaction is only well understood for liquid-state processes. Here we report a chemical clock reaction, in which a solidifying entity, metal-organic framework UiO-66, displays oscillations in crystal dimension and number, as shown by X-ray scattering. In rationalizing this result, we introduce a computational approach, the metal-organic molecular orbital methodology, to pinpoint interaction between the tectonic building blocks that construct the metal-organic framework material. In this way, we show that hydrochloric acid plays the role of autocatalyst, bridging separate processes of condensation and crystallization.

  11. Evidence for a chemical clock in oscillatory formation of UiO-66

    PubMed Central

    Goesten, M. G.; de Lange, M. F.; Olivos-Suarez, A. I.; Bavykina, A. V.; Serra-Crespo, P.; Krywka, C.; Bickelhaupt, F. M.; Kapteijn, F.; Gascon, Jorge

    2016-01-01

    Chemical clocks are often used as exciting classroom experiments, where an induction time is followed by rapidly changing colours that expose oscillating concentration patterns. This type of reaction belongs to a class of nonlinear chemical kinetics also linked to chaos, wave propagation and Turing patterns. Despite its vastness in occurrence and applicability, the clock reaction is only well understood for liquid-state processes. Here we report a chemical clock reaction, in which a solidifying entity, metal–organic framework UiO-66, displays oscillations in crystal dimension and number, as shown by X-ray scattering. In rationalizing this result, we introduce a computational approach, the metal–organic molecular orbital methodology, to pinpoint interaction between the tectonic building blocks that construct the metal–organic framework material. In this way, we show that hydrochloric acid plays the role of autocatalyst, bridging separate processes of condensation and crystallization. PMID:27282410

  12. Can an individualized and comprehensive care strategy improve urinary incontinence (UI) among nursing home residents?

    PubMed

    Tanaka, Yukiko; Nagata, Kumiko; Tanaka, Tomoe; Kuwano, Koichi; Endo, Hidetoshi; Otani, Tetsuya; Nakazawa, Minato; Koyama, Hiroshi

    2009-01-01

    Urinary incontinence (UI) is one of the most common and distressing conditions among nursing home residents. Although scheduled care is usually provided for them, incontinence care should be individualized regarding going to the toilet, changing diapers, and taking food and water. We have developed an individualized and comprehensive care strategy to address the problem. We conducted an intervention study that involved training chiefs of staffs, who in turn trained other staffs, and encouraging residents. A total of 153 elderly subjects selected from 1290 residents in 17 nursing homes were eligible to receive our individualized and comprehensive care. The goals of the care strategy were (i) to complete meal intake; (ii) to take fluids up to 1500 ml/day; (iii) to urinate in a toilet; (iv) to spend over 6h out of bed; and (v) to reduce time spent in wet diapers. We explained the aims of our strategy to the chiefs of staff of each nursing home and instructed them to encourage residents to take an active part in our individualized and comprehensive care strategy for 12 weeks. For 3 days before and after that period, we assessed the changes in fluid volume intake, time spent in wet diapers, size of diaper pads, and urination habits. The result was that fluid volume intake significantly increased (p<0.001) while time spent in wet diapers decreased (p<0.001). The number of residents wearing diapers decreased as did the size of pads during the day (p=0.0017). The proportion of residents using diapers at night was reduced and those using toilets at night increased (p=0.007). This study suggests that such an individualized and comprehensive care strategy can offer a measurable improvement in UI care.

  13. Gaining system design knowledge by systematic design space exploration with graph based design languages

    NASA Astrophysics Data System (ADS)

    Schmidt, Jens; Rudolph, Stephan

    2014-10-01

    The conceptual design phase in the design of complex systems such as satellite propulsion systems heavily relies on an exploration of the feasible design space. This exploration requires both: topological changes in the potential system architecture and consistent parametrical changes in the dimensioning of the existing system components. Since advanced engineering design techniques nowadays advocate a model-based systems engineering (MBSE) approach, graph-based design languages which embed a superset of MBSE-features are consequently used in this work to systematically explore the feasible design space. Design languages allow the design knowledge to be represented, modeled and executed using model-based transformations and combine this among other features with constraint processing techniques. The execution of the design language shown for the satellite propulsion systems in this work yields topologically varied designs (i.e. the selection of a monergol, a diergol or a coldgas system) with consistent parameters. Based on an a posteriori performance analysis of the automatically generated system designs, novel system knowledge (most notably in form of so-called "topology change points") can be gained and extracted from the original point cloud of numerical results.

  14. Biourbanism: Solar based urban and regional design

    SciTech Connect

    Williams, D.

    1999-07-01

    New neighborhoods for an additional one billion people will need to be constructed on the planet within the next 10 years. If the historic patterns of growth continue--the sprawl, the congestion, the draining of swamps, the loss of agricultural land--the requirement for all basic resources will outstrip the availability. While this is of great concern, it is the destruction of an acceptable quality of life--the sense of place--that will be the most difficult and expensive to change. An essential step to reverse the direction of this undesirable future is changing the design and planning of these communities to work with resident solar energies, regional biology, local renewable resources, and sustainable urban planning and design principles. Design can make a difference. This paper develops the view that the solar approach must include urban and regional design and presents solar-based renewable resources example of the design of regions.

  15. Radiometer Design Analysis Based Upon Measurement Uncertainty

    NASA Technical Reports Server (NTRS)

    Racette, Paul E.; Lang, Roger H.

    2004-01-01

    This paper introduces a method for predicting the performance of a radiometer design based on calculating the measurement uncertainty. The variety in radiometer designs and the demand for improved radiometric measurements justify the need for a more general and comprehensive method to assess system performance. Radiometric resolution, or sensitivity, is a figure of merit that has been commonly used to characterize the performance of a radiometer. However when evaluating the performance of a calibration design for a radiometer, the use of radiometric resolution has limited application. These limitations are overcome by considering instead the measurement uncertainty. A method for calculating measurement uncertainty for a generic radiometer design including its calibration algorithm is presented. The result is a generalized technique by which system calibration architectures and design parameters can be studied to optimize instrument performance for given requirements and constraints. Example applications demonstrate the utility of using measurement uncertainty as a figure of merit.

  16. Computer vision based room interior design

    NASA Astrophysics Data System (ADS)

    Ahmad, Nasir; Hussain, Saddam; Ahmad, Kashif; Conci, Nicola

    2015-12-01

    This paper introduces a new application of computer vision. To the best of the author's knowledge, it is the first attempt to incorporate computer vision techniques into room interior designing. The computer vision based interior designing is achieved in two steps: object identification and color assignment. The image segmentation approach is used for the identification of the objects in the room and different color schemes are used for color assignment to these objects. The proposed approach is applied to simple as well as complex images from online sources. The proposed approach not only accelerated the process of interior designing but also made it very efficient by giving multiple alternatives.

  17. Data base systems in electronic design engineering

    NASA Technical Reports Server (NTRS)

    Williams, D.

    1980-01-01

    The concepts of an integrated design data base system (DBMS) as it might apply to an electronic design company are discussed. Data elements of documentation, project specifications, project tracking, firmware, software, electronic and mechanical design can be integrated and managed through a single DBMS. Combining the attributes of a DBMS data handler with specialized systems and functional data can provide users with maximum flexibility, reduced redundancy, and increased overall systems performance. Although some system overhead is lost due to redundancy in transitory data, it is believed the combination of the two data types is advisable rather than trying to do all data handling through a single DBMS.

  18. XAS on Rh and Ir metal sites in post synthetically functionalized UiO-67 Zirconium MOFs

    NASA Astrophysics Data System (ADS)

    Braglia, L.; Borfecchia, E.; Lomachenko, K. A.; Øien, S.; Lillerud, K. P.; Lamberti, C.

    2016-05-01

    We synthesized UiO-67 metal-organic-frameworks (MOFs) functionalized with different transition metals (Rh, Ir). Using EXAFS we verified that the synthesis has been successful. Furthermore, we observed the change of local environment while varying of metal site. XAS spectroscopy is the most informative technique to characterize these kind of materials and to study the local environment around the metal site.

  19. A Study of the Yang-gyeong-gyu-il-ui (兩景揆日儀) in the Joseon Dynasty

    NASA Astrophysics Data System (ADS)

    Lee, Yong Sam; Kim, Sang Hyuk; Mihn, Byeong-Hee

    2015-03-01

    The Yang-gyeong-gyu-il-ui (兩景揆日儀) is a kind of elevation sundial using three wooden plates. Sang-hyeok Lee (李尙爀, 1810~?) and Byeong-cheol Nam (南秉哲, 1817~1863) gave descriptions of this sundial and explained how to use it in their Gyu-il-go (揆日考) and Ui-gi-jip-seol (儀器輯說), respectively. According to Gyu-il-go (揆日考) there are two horizontal plates and two vertical plates that have lines of season and time. Subseasonal (節候) lines are engraved between seasonal (節氣) lines, subdividing the interval into three equal lines of Cho-hu (初候, early subseason), Jung-hu (中候, mid subseason) and Mal-hu (末候, late subseason); there are 13 seasonal lines for a year, thus resulting in 37 subseasonal lines; also, there are 12 double-hour (時辰) lines for a day engraved on these plates. The only remaining artifact of Yang-gyeong-gyu-il-ui was made in 1849 (the 15th year of Heon-jong) and is kept at the Korea University Museum. We have compared and analyzed Yanggyeong- gyu-il-ui and similar western sundials. Also, we have reviewed the scientific aspect of this artifact and built a replica. Yang-gyeong-gyu-il-ui is a new model enhanced from the miniaturization development in the early Joseon Dynasty and can be applied to the southern part of the tropic line through a structure change.

  20. Effects-Based Design of Robust Organizations

    DTIC Science & Technology

    2004-06-01

    turn, are used to synthesize a robust organizational structure. Keywords: Organizational Design, Markov Deci- sion Processes, Reinforcement Learning , and...Markov Decision Processes (MDP), reinforcement learning , Monte Carlo con- trol method, and mixed integer optimization, as in aElectrical and Computer...based on MDP, Monte Carlo control method, reinforcement learning , and mixed integer optimization techniques. In section III, we formulate the dynamic

  1. DSN energy data base preliminary design

    NASA Technical Reports Server (NTRS)

    Cole, E. R.; Herrera, L. O.; Lascu, D. M.

    1979-01-01

    The design and implementation of a computerized data base created to support the DSN Energy Conservation Project with data relating to energy use at Goldstone Deep Space Communications Complex are described. The results of development work to date, are presented along with work currently in progress or in the planning stage.

  2. Habitat quality and recruitment success of cui-ui in the Truckee River downstream of Marble Bluff Dam, Pyramid Lake, Nevada

    USGS Publications Warehouse

    Scoppettone, G. Gary; Rissler, Peter H.; Salgado, J. Antonio; Harry, Beverly

    2013-01-01

    We compared cui-ui (Chasmistes cujus) recruitment from two reaches of the Truckee River with histories of severe erosional downcutting caused by a decline in Pyramid Lake surface elevation. In 1975, Marble Bluff Dam (MBD) was constructed 5 kilometers upstream of the extant mouth of the Truckee River to stabilize the upstream reach of the river; the downstream reach of the river remained unstable and consequently unsuitable for cui-ui recruitment. By the early 2000s, there was a decrease in the Truckee River’s slope from MBD to Pyramid Lake after a series of wet years in the 1990s. This was followed by changes in river morphology and erosion abatement. These changes led to the question as to cui-ui recruitment potential in the Truckee River downstream of MBD. In 2012, more than 7,000 cui-ui spawners were passed upstream of MBD, although an indeterminate number of cui-ui spawned downstream of MBD. In this study, we compared cui-ui recruitment upstream and downstream of MBD during a Truckee River low-flow year (2012). Cui-ui larvae emigration to Pyramid Lake began earlier and ended later downstream of MBD. A greater number of cui-ui larvae was produced downstream of MBD than upstream. This also was true for native Tahoe sucker (Catostomus tahoensis) and Lahontan redside (Richardsonius egregius). The improved Truckee River stability downstream of MBD and concomitant cui-ui recruitment success is attributed to a rise in Pyramid Lake's surface elevation. A decline in lake elevation may lead to a shift in stream morphology and substrate composition to the detriment of cui-ui reproductive success as well as the reproductive success of other native fishes.

  3. Design Concepts for Muon-Based Accelerators

    SciTech Connect

    Ryne, R. D.; Berg, J. S.; Kirk, H. G.; Palmer, R. B.; Stratkis, D.; Alexahin, Y.; Bross, A.; Gollwitzer, K.; Mokhov, N. V.; Neuffer, D.; Palmer, M. A.; Yonehara, K.; Snopok, P.; Bogacz, A.; Roberts, T. J.; Delahaye, J. -P.

    2015-05-01

    Muon-based accelerators have the potential to enable facilities at both the Intensity and the Energy Frontiers. Muon storage rings can serve as high precision neutrino sources, and a muon collider is an ideal technology for a TeV or multi-TeV collider. Progress in muon accelerator designs has advanced steadily in recent years. In regard to 6D muon cooling, detailed and realistic designs now exist that provide more than 5 order-of-magnitude emittance reduction. Furthermore, detector performance studies indicate that with suitable pixelation and timing resolution, backgrounds in the collider detectors can be significantly reduced, thus enabling high-quality physics results. Thanks to these and other advances in design & simulation of muon systems, technology development, and systems demonstrations, muon storage-ring-based neutrino sources and a muon collider appear more feasible than ever before. A muon collider is now arguably among the most compelling approaches to a multi-TeV lepton collider. This paper summarizes the current status of design concepts for muon-based accelerators for neutrino factories and a muon collider.

  4. Reliability based fatigue design and maintenance procedures

    NASA Technical Reports Server (NTRS)

    Hanagud, S.

    1977-01-01

    A stochastic model has been developed to describe a probability for fatigue process by assuming a varying hazard rate. This stochastic model can be used to obtain the desired probability of a crack of certain length at a given location after a certain number of cycles or time. Quantitative estimation of the developed model was also discussed. Application of the model to develop a procedure for reliability-based cost-effective fail-safe structural design is presented. This design procedure includes the reliability improvement due to inspection and repair. Methods of obtaining optimum inspection and maintenance schemes are treated.

  5. Design Strategies for Aptamer-Based Biosensors

    PubMed Central

    Han, Kun; Liang, Zhiqiang; Zhou, Nandi

    2010-01-01

    Aptamers have been widely used as recognition elements for biosensor construction, especially in the detection of proteins or small molecule targets, and regarded as promising alternatives for antibodies in bioassay areas. In this review, we present an overview of reported design strategies for the fabrication of biosensors and classify them into four basic modes: target-induced structure switching mode, sandwich or sandwich-like mode, target-induced dissociation/displacement mode and competitive replacement mode. In view of the unprecedented advantages brought about by aptamers and smart design strategies, aptamer-based biosensors are expected to be one of the most promising devices in bioassay related applications. PMID:22399891

  6. Performance-based asphalt mixture design methodology

    NASA Astrophysics Data System (ADS)

    Ali, Al-Hosain Mansour

    performance based design procedure. Finally, the developed guidelines with easy-to-use flow charts for the integrated mix design methodology are presented.

  7. MMI based Electro-Absorption Modulator Design

    NASA Astrophysics Data System (ADS)

    Sala, A.; Sikorski, Y.

    2007-05-01

    Electro-Absorption Modulators (EAM) are among the most important components of high-speed WDM optical communications devices and systems. During the last decade, multiple EAM designs were proposed and fabricated as stand alone devices, as part of Electro-Absorption Modulated Lasers (EML), and as part of multi component Planar Lightguide Circuits (PLC). Vast majority of all designed and fabricated EAMs employ a straight section of single mode waveguide. In this work, we present a new approach for EAM design which is based on the use of 1*1 Multimode Interference structure (MMI). We demonstrate improvements in the extinction ratio of the EAM based on a combination of electro-absorption and optical interference effects in the MMI structure. The increase in extinction ratio is not accompanied by an increase in insertion loss or chirp, nor does it lead to higher drive voltage or lower bandwidth. The MMI based EAM devices can be easily fabricated using current InP based fabrication technologies and, in-fact, allow for less stringent tolerance requirements than currently used for traditional EAM devices. To cite this abstract, use the following reference: http://meetings.aps.org/link/BAPS.2007.OSS07.P1.4

  8. Design Study: Rocket Based MHD Generator

    NASA Technical Reports Server (NTRS)

    1997-01-01

    This report addresses the technical feasibility and design of a rocket based MHD generator using a sub-scale LOx/RP rocket motor. The design study was constrained by assuming the generator must function within the performance and structural limits of an existing magnet and by assuming realistic limits on (1) the axial electric field, (2) the Hall parameter, (3) current density, and (4) heat flux (given the criteria of heat sink operation). The major results of the work are summarized as follows: (1) A Faraday type of generator with rectangular cross section is designed to operate with a combustor pressure of 300 psi. Based on a magnetic field strength of 1.5 Tesla, the electrical power output from this generator is estimated to be 54.2 KW with potassium seed (weight fraction 3.74%) and 92 KW with cesium seed (weight fraction 9.66%). The former corresponds to a enthalpy extraction ratio of 2.36% while that for the latter is 4.16%; (2) A conceptual design of the Faraday MHD channel is proposed, based on a maximum operating time of 10 to 15 seconds. This concept utilizes a phenolic back wall for inserting the electrodes and inter-electrode insulators. Copper electrode and aluminum oxide insulator are suggested for this channel; and (3) A testing configuration for the sub-scale rocket based MHD system is proposed. An estimate of performance of an ideal rocket based MHD accelerator is performed. With a current density constraint of 5 Amps/cm(exp 2) and a conductivity of 30 Siemens/m, the push power density can be 250, 431, and 750 MW/m(sup 3) when the induced voltage uB have values of 5, 10, and 15 KV/m, respectively.

  9. Neurocomputing strategies in decomposition based structural design

    NASA Technical Reports Server (NTRS)

    Szewczyk, Z.; Hajela, P.

    1993-01-01

    The present paper explores the applicability of neurocomputing strategies in decomposition based structural optimization problems. It is shown that the modeling capability of a backpropagation neural network can be used to detect weak couplings in a system, and to effectively decompose it into smaller, more tractable, subsystems. When such partitioning of a design space is possible, parallel optimization can be performed in each subsystem, with a penalty term added to its objective function to account for constraint violations in all other subsystems. Dependencies among subsystems are represented in terms of global design variables, and a neural network is used to map the relations between these variables and all subsystem constraints. A vector quantization technique, referred to as a z-Network, can effectively be used for this purpose. The approach is illustrated with applications to minimum weight sizing of truss structures with multiple design constraints.

  10. VIEWCACHE: An incremental pointer-base access method for distributed databases. Part 1: The universal index system design document. Part 2: The universal index system low-level design document. Part 3: User's guide. Part 4: Reference manual. Part 5: UIMS test suite

    NASA Technical Reports Server (NTRS)

    Kelley, Steve; Roussopoulos, Nick; Sellis, Timos

    1992-01-01

    The goal of the Universal Index System (UIS), is to provide an easy-to-use and reliable interface to many different kinds of database systems. The impetus for this system was to simplify database index management for users, thus encouraging the use of indexes. As the idea grew into an actual system design, the concept of increasing database performance by facilitating the use of time-saving techniques at the user level became a theme for the project. This Final Report describes the Design, the Implementation of UIS, and its Language Interfaces. It also includes the User's Guide and the Reference Manual.

  11. Creating A Data Base For Design Of An Impeller

    NASA Technical Reports Server (NTRS)

    Prueger, George H.; Chen, Wei-Chung

    1993-01-01

    Report describes use of Taguchi method of parametric design to create data base facilitating optimization of design of impeller in centrifugal pump. Data base enables systematic design analysis covering all significant design parameters. Reduces time and cost of parametric optimization of design: for particular impeller considered, one can cover 4,374 designs by computational simulations of performance for only 18 cases.

  12. A decision-based perspective for the design of methods for systems design

    NASA Technical Reports Server (NTRS)

    Mistree, Farrokh; Muster, Douglas; Shupe, Jon A.; Allen, Janet K.

    1989-01-01

    Organization of material, a definition of decision based design, a hierarchy of decision based design, the decision support problem technique, a conceptual model design that can be manufactured and maintained, meta-design, computer-based design, action learning, and the characteristics of decisions are among the topics covered.

  13. Design and Construction of Manned Lunar Base

    NASA Astrophysics Data System (ADS)

    Li, Zhijie

    2016-07-01

    Building manned lunar base is one of the core aims of human lunar exploration project, which is also an important way to carry out the exploitation and utilization of lunar in situ resources. The most important part of manned lunar base is the design and construction of living habitation and many factors should be considered including science objective and site selection. Through investigating and research, the scientific goals of manned lunar base should be status and characteristics ascertainment of lunar available in situ resources, then developing necessary scientific experiments and utilization of lunar in situ resources by using special environment conditions of lunar surface. The site selection strategy of manned lunar base should rely on scientific goals according to special lunar surface environment and engineering capacity constraints, meanwhile, consulting the landing sites of foreign unmanned and manned lunar exploration, and choosing different typical regions of lunar surface and analyzing the landform and physiognomy, reachability, thermal environment, sunlight condition, micro meteoroids protection and utilization of in situ resources, after these steps, a logical lunar living habitation site should be confirmed. This paper brings out and compares three kinds of configurations with fabricating processes of manned lunar base, including rigid module, flexible and construction module manned lunar base. 1.The rigid habitation module is usually made by metal materials. The design and fabrication may consult the experience of space station, hence with mature technique. Because this configuration cannot be folded or deployed, which not only afford limit working and living room for astronauts, but also needs repetitious cargo transit between earth and moon for lunar base extending. 2. The flexible module habitation can be folded in fairing while launching. When deploying on moon, the configuration can be inflatable or mechanically-deployed, which means under

  14. A XAFS study of the local environment and reactivity of Pt- sites in functionalized UiO-67 MOFs

    NASA Astrophysics Data System (ADS)

    Borfecchia, E.; Øien, S.; Svelle, S.; Mino, L.; Braglia, L.; Agostini, G.; Gallo, E.; Lomachenko, K. A.; Bordiga, S.; Guda, A. A.; Soldatov, M. A.; Soldatov, A. V.; Olsbye, U.; Lillerud, K. P.; Lamberti, C.

    2016-05-01

    We synthesized UiO-67 Metal Organic Frameworks (MOFs) functionalized with bpydcPt(II)Cl2 and bpydcPt(IV)Cl4 complexes (bpydc = bipyridine-dicarboxylate), as attractive candidates for the heterogenization of homogeneous catalytic reactions. Pt L3-edge XAFS experiments allowed us to thoroughly characterize these materials, in the local environment of the Pt centers. XAFS studies evidenced the rich reactivity of UiO-67-Pt(II) MOFs, including reduction to bpydcPt(0) under H2 flow in the 600-700 K range, room-temperature oxidation to bpydcPt(IV)Br4 through oxidative addition of liquid Br2 and ligand exchange between 2 Cl- and even bulky ligands such as toluene-3,4-dithiol. Preliminary XANES simulations with ADF code provide additional information on the oxidation state of Pt sites.

  15. Defect-dependent colossal negative thermal expansion in UiO-66(Hf) metal-organic framework.

    PubMed

    Cliffe, Matthew J; Hill, Joshua A; Murray, Claire A; Coudert, François-Xavier; Goodwin, Andrew L

    2015-05-07

    Thermally-densified hafnium terephthalate UiO-66(Hf) is shown to exhibit the strongest isotropic negative thermal expansion (NTE) effect yet reported for a metal-organic framework (MOF). Incorporation of correlated vacancy defects within the framework affects both the extent of thermal densification and the magnitude of NTE observed in the densified product. We thus demonstrate that defect inclusion can be used to tune systematically the physical behaviour of a MOF.

  16. Tuning Pt and Cu sites population inside functionalized UiO-67 MOF by controlling activation conditions.

    PubMed

    Braglia, L; Borfecchia, E; Lomachenko, K A; Bugaev, A L; Guda, A A; Soldatov, A V; Bleken, B T L; Øien-Ødegaard, S; Olsbye, U; Lillerud, K P; Bordiga, S; Agostini, G; Manzoli, M; Lamberti, C

    2017-09-08

    The exceptional thermal and chemical stability of the UiO-66, -67 and -68 classes of isostructural MOFs [J. Am. Chem. Soc., 2008, 130, 13850] makes them ideal materials for functionalization purposes aimed at introducing active centres for potential application in heterogeneous catalysis. We previously demonstrated that a small fraction (up to 10%) of the linkers in the UiO-67 MOF can be replaced by bipyridine-dicarboxylate (bpydc) moieties exhibiting metal-chelating ability and enabling the grafting of Pt(ii) and Pt(iv) ions in the MOF framework [Chem. Mater., 2015, 27, 1042] upon interaction with PtCl2 or PtCl4 precursors. Herein we extend this functionalization approach in two directions. First, we show that by controlling the activation of the UiO-67-Pt we can move from a material hosting isolated Pt(ii) sites anchored to the MOF framework with Pt(ii) exhibiting two coordination vacancies (potentially interesting for C-H bond activation) to the formation of very small Pt nanoparticles hosted inside the MOF cavities (potentially interesting for hydrogenation reactions). The second direction consists of the extension of the approach to the insertion of Cu(ii), obtained via interaction with CuCl2, and exhibiting interesting redox properties. All materials have been characterized by in situ X-ray absorption spectroscopy at the Pt L3- and Cu K-edges.

  17. Switching of magnetic ground states across the UI r1 -xR hxGe alloy system

    NASA Astrophysics Data System (ADS)

    Pospíšil, Jiří; Haga, Yoshinori; Kambe, Shinsaku; Tokunaga, Yo; Tateiwa, Naoyuki; Aoki, Dai; Honda, Fuminori; Nakamura, Ai; Homma, Yoshiya; Yamamoto, Etsuji; Yamamura, Tomoo

    2017-04-01

    We investigated the evolution of magnetism in the UI r1 -xR hxGe system by the systematic study of high-quality single crystals. Lattice parameters of both parent compounds are very similar, resulting in almost identical nearest interatomic uranium distances close to the Hill limit. We established the x -T phase diagram of the UI r1 -xR hxGe system and found a discontinuous antiferromagnetic/ferromagnetic boundary at xcrit=0.56 , where a local minimum in ordering temperature and maximum of the Sommerfeld coefficient γ ≈175 mJ /mol K2 occurs in the UCoGe-URhGe-UIrGe system, signaling an increase in magnetic fluctuation. However, a quantum critical point is not realized because of the finite ordering temperature at xcrit. A magnon gap on the antiferromagnetic side abruptly suppresses magnetic fluctuations. We find a field-induced first order transition in the vicinity of the critical magnetic field along the b axis (Hb ,crit) in the entire UI r1 -xR hxGe system, including the ferromagnetic region ˜UC o0.6R h0.4Ge -URhGe .

  18. Carbon dioxide adsorption in amine-functionalized mixed-ligand metal-organic frameworks of UiO-66 topology.

    PubMed

    Ethiraj, Jayashree; Albanese, Elisa; Civalleri, Bartolomeo; Vitillo, Jenny G; Bonino, Francesca; Chavan, Sachin; Shearer, Greig C; Lillerud, Karl Petter; Bordiga, Silvia

    2014-12-01

    A series of mixed-ligand [1,4-benzenedicarboxylic acid (BDC)/2-amino-1,4-benzenedicarboxylic acid (ABDC)] UiO-66 metal-organic frameworks (MOFs) synthesized through two different methods (low (LT) and high temperature (HT)) have been investigated for their carbon dioxide adsorption properties from 0 to 1 bar to clarify the role of amino loading on carbon dioxide uptake. Volumetric CO2 isotherms show that the CO2 capacity (normalized to the Langmuir surface area) increases with a degree of functionalization of about 46%; for similar NH2 contents, the same values are found for both synthetic procedures. Microcalorimetric isotherms reveal that amino-functionalized materials have a larger differential heat of adsorption (q(diff) ) towards CO2 ; reaching 27(25) and 20(22) kJ mol(-1) on HT(LT)-UiO-66-NH2 and UiO-66, respectively, at the lowest equilibrium pressures used in this study. All experimental results are supported by values obtained through quantum mechanical calculations.

  19. Reverse shape selectivity in the liquid-phase adsorption of xylene isomers in zirconium terephthalate MOF UiO-66.

    PubMed

    Moreira, Mariana A; Santos, João C; Ferreira, Alexandre F P; Loureiro, José M; Ragon, Florence; Horcajada, Patricia; Shim, Kyu-E; Hwang, Young-K; Lee, U-Hwang; Chang, Jong-S; Serre, Christian; Rodrigues, Alírio E

    2012-04-03

    Powder, agglomerates, and tablets of the microporous zirconium(IV) terephthalate metal-organic framework UiO-66 were evaluated for the selective adsorption and separation of xylene isomers in the liquid phase using n-heptane as the eluent. Pulse experiments, performed at 313 K in the presence of n-heptane, revealed the o-xylene preference of this material, which was further confirmed by binary and multicomponent breakthrough experiments in the presence of m- and p-xylene, resulting in selectivities at 313 K of 1.8 and 2.4 with regards to m-xylene and p-xylene, respectively. Additionally, because p-xylene is the less retained isomer, UiO-66 presents a selectivity pattern that is reverse of that of the xylenes' molecular dimension with respect to shape selectivity. The shaping of the material as tablets did not significantly change its selectivity toward the o-xylene isomer or toward p-xylene, which was the less retained isomer, despite a loss in capacity. Finally, the selectivity behavior of UiO-66 in the liquid n-heptane phase makes it a suitable material for o-xylene separation in the extract (heavy product) or p-xylene separation in the raffinate (light product) by simulated moving bed technology.

  20. Reliability-Based Electronics Shielding Design Tools

    NASA Technical Reports Server (NTRS)

    Wilson, J. W.; O'Neill, P. J.; Zang, T. A.; Pandolf, J. E.; Tripathi, R. K.; Koontz, Steven L.; Boeder, P.; Reddell, B.; Pankop, C.

    2007-01-01

    Shielding design on large human-rated systems allows minimization of radiation impact on electronic systems. Shielding design tools require adequate methods for evaluation of design layouts, guiding qualification testing, and adequate follow-up on final design evaluation.

  1. Sequential ensemble-based optimal design for parameter estimation: SEQUENTIAL ENSEMBLE-BASED OPTIMAL DESIGN

    SciTech Connect

    Man, Jun; Zhang, Jiangjiang; Li, Weixuan; Zeng, Lingzao; Wu, Laosheng

    2016-10-01

    The ensemble Kalman filter (EnKF) has been widely used in parameter estimation for hydrological models. The focus of most previous studies was to develop more efficient analysis (estimation) algorithms. On the other hand, it is intuitively understandable that a well-designed sampling (data-collection) strategy should provide more informative measurements and subsequently improve the parameter estimation. In this work, a Sequential Ensemble-based Optimal Design (SEOD) method, coupled with EnKF, information theory and sequential optimal design, is proposed to improve the performance of parameter estimation. Based on the first-order and second-order statistics, different information metrics including the Shannon entropy difference (SD), degrees of freedom for signal (DFS) and relative entropy (RE) are used to design the optimal sampling strategy, respectively. The effectiveness of the proposed method is illustrated by synthetic one-dimensional and two-dimensional unsaturated flow case studies. It is shown that the designed sampling strategies can provide more accurate parameter estimation and state prediction compared with conventional sampling strategies. Optimal sampling designs based on various information metrics perform similarly in our cases. The effect of ensemble size on the optimal design is also investigated. Overall, larger ensemble size improves the parameter estimation and convergence of optimal sampling strategy. Although the proposed method is applied to unsaturated flow problems in this study, it can be equally applied in any other hydrological problems.

  2. Comparing Linkage Designs Based on Land Facets to Linkage Designs Based on Focal Species

    PubMed Central

    Brost, Brian M.; Beier, Paul

    2012-01-01

    Least-cost modeling for focal species is the most widely used method for designing conservation corridors and linkages. However, these designs depend on today's land covers, which will be altered by climate change. We recently proposed an alternative approach based on land facets (recurring landscape units of relatively uniform topography and soils). The rationale is that corridors with high continuity of individual land facets will facilitate movement of species associated with each facet today and in the future. Conservation practitioners might like to know whether a linkage design based on land facets is likely to provide continuity of modeled breeding habitat for species needing connectivity today, and whether a linkage for focal species provides continuity and interspersion of land facets. To address these questions, we compared linkages designed for focal species and land facets in three landscapes in Arizona, USA. We used two variables to measure linkage utility, namely distances between patches of modeled breeding habitat for 5–16 focal species in each linkage, and resistance profiles for focal species and land facets between patches connected by the linkage. Compared to focal species designs, linkage designs based on land facets provided as much or more modeled habitat connectivity for 25 of 28 species-landscape combinations, failing only for the three species with the most narrowly distributed habitat. Compared to land facets designs, focal species linkages provided lower connectivity for about half the land facets in two landscapes. In areas where a focal species approach to linkage design is not possible, our results suggest that conservation practitioners may be able to implement a land facets approach with some confidence that the linkage design would serve most potential focal species. In areas where focal species designs are possible, we recommend using the land facet approach to complement, rather than replace, focal species approaches. PMID

  3. Protein Structure Network-based Drug Design.

    PubMed

    Liang, Zhongjie; Hu, Guang

    2016-01-01

    Although structure-based drug design (SBDD) has become an indispensable tool in drug discovery for a long time, it continues to pose major challenges to date. With the advancement of "omics" techniques, systems biology has enriched SBDD into a new era, called polypharmacology, in which multi-targets drug or drug combination is designed to fight complex diseases. As a preliminary tool in systems biology, protein structure networks (PSNs) treat a protein as a set of residues linked by edges corresponding to the intramolecular interactions existing in folded structures between the residues. The PSN offers a computationally efficient tool to study the structure and function of proteins, and thus may facilitate structurebased drug design. Herein, we provide an overview of recent advances in PSNs, from predicting functionally important residues, to charactering protein-protein interactions and allosteric communication paths. Furthermore, we discuss potential pharmacological applications of PSN concepts and tools, and highlight the application to two families of drug targets, GPCRs and Hsp90. Although the application of PSNs as a framework for computer-aided drug discovery has been limited to date, we put forward the potential utility value in the near future and propose the PSNs could also serve as a new tool for polypharmacology research.

  4. Advances in structure-based vaccine design

    PubMed Central

    Kulp, Daniel W; Schief, William R

    2014-01-01

    Despite the tremendous successes of current vaccines, infectious diseases still take a heavy toll on the global population, and that provides strong rationale for broadening our vaccine development repertoire. Structural vaccinology, in which protein structure information is utilized to design immunogens, has promise to provide new vaccines against traditionally difficult targets. Crystal structures of antigens containing one or more protection epitopes, especially when in complex with a protective antibody, are the launching point for immunogen design. Integrating structure and sequence information for families of broadly neutralizing antibodies (bNAbs) has recently enabled the creation of germline-targeting immunogens that bind and activate germline B-cells in order to initiate the elicitation of such antibodies. The contacts between antigen and neutralizing antibody define a structural epitope, and methods have been developed to transplant epitopes to scaffold proteins for structural stabilization, and to design minimized antigens that retain one or more key epitopes while eliminating other potentially distracting or unnecessary features. To develop vaccines that protect against antigenically variable pathogens, pioneering structure-based work demonstrated that multiple strain-specific epitopes could be engineered onto a single immunogen. We review these recent structural vaccinology efforts to engineer germline-targeting, epitope-specific, and/or broad coverage immunogens. PMID:23806515

  5. Designing biomimetic pores based on carbon nanotubes

    PubMed Central

    García-Fandiño, Rebeca; Sansom, Mark S. P.

    2012-01-01

    Biomimetic nanopores based on membrane-spanning single-walled carbon nanotubes have been designed to include selectivity filters based on combinations of anionic and cationic groups mimicking those present in bacterial porins and in voltage-gated sodium and calcium channels. The ion permeation and selectivity properties of these nanopores when embedded in a phospholipid bilayer have been explored by molecular dynamics simulations and free energy profile calculations. The interactions of the nanopores with sodium, potassium, calcium, and chloride ions have been explored as a function of the number of anionic and cationic groups within the selectivity filter. Unbiased molecular dynamics simulations show that the overall selectivity is largely determined by the net charge of the filter. Analysis of distribution functions reveals considerable structuring of the distribution of ions and water within the nanopores. The distributions of ions along the pore axis reveal local selectivity for cations around filter, even in those nanopores (C0) where the net filter charge is zero. Single ion free energy profiles also reveal clear evidence for cation selectivity, even in the C0 nanopores. Detailed analysis of the interactions of the C0 nanopore with Ca2+ ions reveals that local interactions with the anionic (carboxylate) groups of the selectivity filter lead to (partial) replacement of solvating water as the ion passes through the pore. These studies suggest that a computational biomimetic approach can be used to evaluate our understanding of the design principles of nanopores and channels. PMID:22509000

  6. Design of nanostructured-based glucose biosensors

    NASA Astrophysics Data System (ADS)

    Komirisetty, Archana; Williams, Frances; Pradhan, Aswini; Konda, Rajini B.; Dondapati, Hareesh; Samantaray, Diptirani

    2012-04-01

    This paper presents the design of glucose sensors that will be integrated with advanced nano-materials, bio-coatings and electronics to create novel devices that are highly sensitive, inexpensive, accurate, and reliable. In the work presented, a glucose biosensor and its fabrication process flow have been designed. The device is based on electrochemical sensing using a working electrode with bio-functionalized zinc oxide (ZnO) nano-rods. Among all metal oxide nanostructures, ZnO nano-materials play a significant role as a sensing element in biosensors due to their properties such as high isoelectric point (IEP), fast electron transfer, non-toxicity, biocompatibility, and chemical stability which are very crucial parameters to achieve high sensitivity. Amperometric enzyme electrodes based on glucose oxidase (GOx) are used due to their stability and high selectivity to glucose. The device also consists of silicon dioxide and titanium layers as well as platinum working and counter electrodes and a silver/silver chloride reference electrode. Currently, the biosensors are being fabricated using the process flow developed. Once completed, the sensors will be bio-functionalized and tested to characterize their performance, including their sensitivity and stability.

  7. Designing a Constraint Based Parser for Sanskrit

    NASA Astrophysics Data System (ADS)

    Kulkarni, Amba; Pokar, Sheetal; Shukl, Devanand

    Verbal understanding (śā bdabodha) of any utterance requires the knowledge of how words in that utterance are related to each other. Such knowledge is usually available in the form of cognition of grammatical relations. Generative grammars describe how a language codes these relations. Thus the knowledge of what information various grammatical relations convey is available from the generation point of view and not the analysis point of view. In order to develop a parser based on any grammar one should then know precisely the semantic content of the grammatical relations expressed in a language string, the clues for extracting these relations and finally whether these relations are expressed explicitly or implicitly. Based on the design principles that emerge from this knowledge, we model the parser as finding a directed Tree, given a graph with nodes representing the words and edges representing the possible relations between them. Further, we also use the Mīmā ṃsā constraint of ākā ṅkṣā (expectancy) to rule out non-solutions and sannidhi (proximity) to prioritize the solutions. We have implemented a parser based on these principles and its performance was found to be satisfactory giving us a confidence to extend its functionality to handle the complex sentences.

  8. SNAD: Sequence Name Annotation-based Designer.

    PubMed

    Sidorov, Igor A; Reshetov, Denis A; Gorbalenya, Alexander E

    2009-08-14

    A growing diversity of biological data is tagged with unique identifiers (UIDs) associated with polynucleotides and proteins to ensure efficient computer-mediated data storage, maintenance, and processing. These identifiers, which are not informative for most people, are often substituted by biologically meaningful names in various presentations to facilitate utilization and dissemination of sequence-based knowledge. This substitution is commonly done manually that may be a tedious exercise prone to mistakes and omissions. Here we introduce SNAD (Sequence Name Annotation-based Designer) that mediates automatic conversion of sequence UIDs (associated with multiple alignment or phylogenetic tree, or supplied as plain text list) into biologically meaningful names and acronyms. This conversion is directed by precompiled or user-defined templates that exploit wealth of annotation available in cognate entries of external databases. Using examples, we demonstrate how this tool can be used to generate names for practical purposes, particularly in virology. A tool for controllable annotation-based conversion of sequence UIDs into biologically meaningful names and acronyms has been developed and placed into service, fostering links between quality of sequence annotation, and efficiency of communication and knowledge dissemination among researchers.

  9. Structural determination of a highly stable metal-organic framework with possible application to interim radioactive waste scavenging: Hf-UiO-66

    NASA Astrophysics Data System (ADS)

    Jakobsen, Søren; Gianolio, Diego; Wragg, David S.; Nilsen, Merete Hellner; Emerich, Hermann; Bordiga, Silvia; Lamberti, Carlo; Olsbye, Unni; Tilset, Mats; Lillerud, Karl Petter

    2012-09-01

    High-resolution synchrotron radiation x-ray powder diffraction (HR-XRPD) combined with Hf L3-edge extended x-ray absorption fine structure allowed us to determine the structure of a Hf-UiO-66 metal-organic framework (MOF) showing that it is isoreticular to Zr-UiO-66 MOF [Cavka , J. Am. Chem. Soc.JACSAT0002-786310.1021/ja8057953 130, 13850 (2008).]. Thermal gravimetric measurements (coupled with mass spectroscopy) and temperature-dependent synchrotron radiation XRPD proved the high thermal stability of the Hf-UiO-66 MOF. The Langmuir surface area (849 m2/g) combined with the high stability of the UiO-66 framework and with the high neutron absorption cross section of Hf suggest that among all microporous crystalline materials the Hf-UiO-66 MOF possesses the physical and chemical requirements for the interim storage of radioactive waste in a much safer way than is currently available. The first results proving the synthesis of a MOF material with UiO-66 topology realized by a B-containing linker are also reported, allowing a further improvement of the neutron shielding power of this class of materials.

  10. Thin-Film Nanocomposite (TFN) Membranes Incorporated with Super-Hydrophilic Metal-Organic Framework (MOF) UiO-66: Toward Enhancement of Water Flux and Salt Rejection.

    PubMed

    Ma, Dangchen; Peh, Shing Bo; Han, Gang; Chen, Shing Bor

    2017-03-01

    Zirconiumv (IV)-carboxylate metal-organic framework (MOF) UiO-66 nanoparticles were successfully synthesized and incorporated in the polyamide (PA) selective layer to fabricate novel thin-film nanocomposite (TFN) membranes. Compared to unmodified pure polyamide thin-film composite (TFC) membranes, the incorporation of UiO-66 nanoparticles significantly changes the membrane morphology and chemistry, leading to an improvement of intrinsic separation properties due to the molecular sieving and superhydrophilic nature of UiO-66 particles. The best performing TFN-U2 (0.1 wt % particle loading) membrane not only shows a 52% increase of water permeability but also maintains salt rejection levels (∼95%) similar to the benchmark. The effects of UiO-66 loading on the forward osmosis (FO) performance were also investigated. Incorporation of 0.1 wt % UiO-66 produced a maximum water flux increase of 40% and 25% over the TFC control under PRO and FO modes, when 1 M NaCl was used as the draw solution against deionized water feed. Meanwhile, solute reverse flux was maintained at a relatively low level. In addition, TFN-U2 membrane displayed a relatively linear increase in FO water flux with increasing NaCl concentration up to 2.0 M, suggesting a slightly reduced internal concentration polarization effect. To our best knowledge, the current study is the first to consider implementation of Zr-MOFs (UiO-66) onto TFN-FO membranes.

  11. A Task-Based Design Guide for Command and Control

    DTIC Science & Technology

    2012-06-01

    Decisions & Focal Tasks Cognitive Notional Paper Prototype Walkthrough Cognitive Walkthroughs & Usability Analyses UCD is an HFE best practice...reduce the current burden of user cognition and recall. This approach will enhance the usability of command and control systems, reduce the life cycle...COCOM). With usability issues becoming widespread in the C2 community, there is now an even greater need for UI standardization, which is advanced by

  12. Muscle fatigue based evaluation of bicycle design.

    PubMed

    Balasubramanian, V; Jagannath, M; Adalarasu, K

    2014-03-01

    Bicycling posture leads to considerable discomfort and a variety of chronic injuries. This necessitates a proper bicycle design to avoid injuries and thereby enhance rider comfort. The objective of this study was to investigate the muscle activity during cycling on three different bicycle designs, i.e., rigid frame (RF), suspension (SU) and sports (SP) using surface electromyography (sEMG). Twelve male volunteers participated in this study. sEMG signals were acquired bilaterally from extensor carpi radialis (ECR), trapezius medial (TM), latissimus dorsi medial (LDM) and erector spinae (ES), during 30 min of cycling on each bicycle and after cycling. Time domain (RMS) and frequency domain (MPF) parameters were extracted from acquired sEMG signals. From the sEMG study, it was found that the fatigue in right LDM and ES were significantly (p < 0.05) higher in SP bicycle. This was corroborated by a psychophysical assessment based on RBG pain scale. The study also showed that there was a significantly lesser fatigue with the SU bicycle than the RF and SP bicycles.

  13. Reflection Modeling Based Broadband Matching Network Design

    NASA Astrophysics Data System (ADS)

    Şengül, Metin

    2017-09-01

    In this paper, a new broadband matching network design approach based on reflection modeling is proposed, which has two parts: impedance data generation and modeling. In the approach, firstly the output impedance data of the matching network is obtained to get the desired flat transducer power gain in the passband. Next the output reflection data are calculated using the obtained impedance data, then they are modeled as a bounded real function. Then this function is synthesized and the desired lossless matching network with initial element values is obtained. A double matching example is solved to illustrate the use of the proposed approach. It is seen that proposed approach provides suitable initials for CAD tools for final trimming.

  14. Synthesis, structures and reactivity of ruthenium nitrosyl complexes containing Kläui's oxygen tripodal ligand.

    PubMed

    Ip, Ho-Fai; Yi, Xiao-Yi; Wong, Wai-Yeung; Williams, Ian D; Leung, Wa-Hung

    2011-11-07

    Ruthenium nitrosyl complexes containing the Kläui's oxgyen tripodal ligand L(OEt)(-) ([CpCo{P(O)(OEt)(2)}(3)](-) where Cp = η(5)-C(5)H(5)) were synthesized and their photolysis studied. The treatment of [Ru(N^N)(NO)Cl(3)] with [AgL(OEt)] and Ag(OTf) afforded [L(OEt)Ru(N^N)(NO)][OTf](2) where N^N = 4,4'-di-tert-butyl-2,2'-bipyridyl (dtbpy) (2·[OTf](2)), 2,2'-bipyridyl (bpy) (3·[OTf](2)), N,N,N'N'-tetramethylethylenediamine (4·[OTf](2)). Anion metathesis of 3·[OTf](2) with HPF(6) and HBF(4) gave 3·[PF(6)](2) and 3·[BF(4)](2), respectively. Similarly, the PF(6)(-) salt 4·[PF(6)](2) was prepared by the reaction of 4·[OTf](2) with HPF(6). The irradiation of [L(OEt)Ru(NO)Cl(2)] (1) with UV light in CH(2)Cl(2)-MeCN and tetrahydrofuran (thf)-H(2)O afforded [L(OEt)RuCl(2)(MeCN)] (5) and the chloro-bridged dimer [L(OEt)RuCl](2)(μ-Cl)(2) (6), respectively. The photolysis of complex [2][OTf](2) in MeCN gave [L(OEt)Ru(dtbpy)(MeCN)][OTf](2) (7). Refluxing complex 5 with RNH(2) in thf gave [L(OEt)RuCl(2)(NH(2)R)] (R = tBu (8), p-tol (9), Ph (10)). The oxidation of complex 6 with PhICl(2) gave [L(OEt)RuCl(3)] (11), whereas the reduction of complex 6 with Zn and NH(4)PF(6) in MeCN yielded [L(OEt)Ru(MeCN)(3)][PF(6)] (12). The reaction of 3·[BF(4)](2) with benzylamine afforded the μ-dinitrogen complex [{L(OEt)Ru(bpy)}(2)(μ-N(2))][BF(4)](2) (13) that was oxidized by [Cp(2)Fe]PF(6) to a mixed valence Ru(II,III) species. The formal potentials of the RuL(OEt) complexes have been determined by cyclic voltammetry. The structures of complexes 5,6,10,11 and 13 have been established by X-ray crystallography.

  15. Problem Based Learning in Constructed Textile Design

    ERIC Educational Resources Information Center

    Sayer, Kate; Wilson, Jacquie; Challis, Simon

    2006-01-01

    Staff observing undergraduate students enrolled on the BSc Hons Textile Design and Design Management programme in The School of Materials, The University of Manchester, identified difficulties with knowledge retention in the area of constructed textile design. Consequently an experimental pilot was carried out in seamless knitwear design using a…

  16. Problem Based Learning in Constructed Textile Design

    ERIC Educational Resources Information Center

    Sayer, Kate; Wilson, Jacquie; Challis, Simon

    2006-01-01

    Staff observing undergraduate students enrolled on the BSc Hons Textile Design and Design Management programme in The School of Materials, The University of Manchester, identified difficulties with knowledge retention in the area of constructed textile design. Consequently an experimental pilot was carried out in seamless knitwear design using a…

  17. CFD based draft tube hydraulic design optimization

    NASA Astrophysics Data System (ADS)

    McNabb, J.; Devals, C.; Kyriacou, S. A.; Murry, N.; Mullins, B. F.

    2014-03-01

    The draft tube design of a hydraulic turbine, particularly in low to medium head applications, plays an important role in determining the efficiency and power characteristics of the overall machine, since an important proportion of the available energy, being in kinetic form leaving the runner, needs to be recovered by the draft tube into static head. For large units, these efficiency and power characteristics can equate to large sums of money when considering the anticipated selling price of the energy produced over the machine's life-cycle. This same draft tube design is also a key factor in determining the overall civil costs of the powerhouse, primarily in excavation and concreting, which can amount to similar orders of magnitude as the price of the energy produced. Therefore, there is a need to find the optimum compromise between these two conflicting requirements. In this paper, an elaborate approach is described for dealing with this optimization problem. First, the draft tube's detailed geometry is defined as a function of a comprehensive set of design parameters (about 20 of which a subset is allowed to vary during the optimization process) and are then used in a non-uniform rational B-spline based geometric modeller to fully define the wetted surfaces geometry. Since the performance of the draft tube is largely governed by 3D viscous effects, such as boundary layer separation from the walls and swirling flow characteristics, which in turn governs the portion of the available kinetic energy which will be converted into pressure, a full 3D meshing and Navier-Stokes analysis is performed for each design. What makes this even more challenging is the fact that the inlet velocity distribution to the draft tube is governed by the runner at each of the various operating conditions that are of interest for the exploitation of the powerhouse. In order to determine these inlet conditions, a combined steady-state runner and an initial draft tube analysis, using a

  18. Complex Educational Design: A Course Design Model Based on Complexity

    ERIC Educational Resources Information Center

    Freire, Maximina Maria

    2013-01-01

    Purpose: This article aims at presenting a conceptual framework which, theoretically grounded on complexity, provides the basis to conceive of online language courses that intend to respond to the needs of students and society. Design/methodology/approach: This paper is introduced by reflections on distance education and on the paradigmatic view…

  19. Chip Design Process Optimization Based on Design Quality Assessment

    NASA Astrophysics Data System (ADS)

    Häusler, Stefan; Blaschke, Jana; Sebeke, Christian; Rosenstiel, Wolfgang; Hahn, Axel

    2010-06-01

    Nowadays, the managing of product development projects is increasingly challenging. Especially the IC design of ASICs with both analog and digital components (mixed-signal design) is becoming more and more complex, while the time-to-market window narrows at the same time. Still, high quality standards must be fulfilled. Projects and their status are becoming less transparent due to this complexity. This makes the planning and execution of projects rather difficult. Therefore, there is a need for efficient project control. A main challenge is the objective evaluation of the current development status. Are all requirements successfully verified? Are all intermediate goals achieved? Companies often develop special solutions that are not reusable in other projects. This makes the quality measurement process itself less efficient and produces too much overhead. The method proposed in this paper is a contribution to solve these issues. It is applied at a German design house for analog mixed-signal IC design. This paper presents the results of a case study and introduces an optimized project scheduling on the basis of quality assessment results.

  20. Designing Tools for Reflection on Problem-Based Instruction and Problem-Based Instructional Design

    ERIC Educational Resources Information Center

    Keefer, Matthew W.; Hui, Diane; RuffusDoerr, Amy Marie

    2009-01-01

    The objective of this research project into teacher education was to document the collaborative development and refection on teachers' tools in a problem-based learning (PBL) program. These results were then used to design materials and formats for the transmission of this teaching knowledge to less-experienced PBL teachers. The tools were…

  1. Michelson interferometer based interleaver design using classic IIR filter decomposition.

    PubMed

    Cheng, Chi-Hao; Tang, Shasha

    2013-12-16

    An elegant method to design a Michelson interferometer based interleaver using a classic infinite impulse response (IIR) filter such as Butterworth, Chebyshev, and elliptic filters as a starting point are presented. The proposed design method allows engineers to design a Michelson interferometer based interleaver from specifications seamlessly. Simulation results are presented to demonstrate the validity of the proposed design method.

  2. Design and Demonstration of Minimal Lunar Base

    NASA Astrophysics Data System (ADS)

    Boche-Sauvan, L.; Foing, B. H.; Exohab Team

    2009-04-01

    Introduction: We propose a conceptual analysis of a first minimal lunar base, in focussing on the system aspects and coordinating every different part as part an evolving architecture [1-3]. We justify the case for a scientific outpost allowing experiments, sample analysis in laboratory (relevant to the origin and evolution of the Earth, geophysical and geochemical studies of the Moon, life sciences, observation from the Moon). Research: Research activities will be conducted with this first settlement in: - science (of, from and on the Moon) - exploration (robotic mobility, rover, drilling), - technology (communication, command, organisation, automatism). Life sciences. The life sciences aspects are considered through a life support for a crew of 4 (habitat) and a laboratory activity with biological experiments performed on Earth or LEO, but then without any magnetosphere protection and therefore with direct cosmic rays and solar particle effects. Moreover, the ability of studying the lunar environment in the field will be a big asset before settling a permanent base [3-5]. Lunar environment. The lunar environment adds constraints to instruments specifications (vacuum, extreme temperature, regolith, seism, micrometeorites). SMART-1 and other missions data will bring geometrical, chemical and physical details about the environment (soil material characteristics, on surface conditions …). Test bench. To assess planetary technologies and operations preparing for Mars human exploration. Lunar outpost predesign modular concept: To allow a human presence on the moon and to carry out these experiments, we will give a pre-design of a human minimal lunar base. Through a modular concept, this base will be possibly evolved into a long duration or permanent base. We will analyse the possibilities of settling such a minimal base by means of the current and near term propulsion technology, as a full Ariane 5 ME carrying 1.7 T of gross payload to the surface of the Moon

  3. Autonomous entropy-based intelligent experimental design

    NASA Astrophysics Data System (ADS)

    Malakar, Nabin Kumar

    2011-07-01

    The aim of this thesis is to explore the application of probability and information theory in experimental design, and to do so in a way that combines what we know about inference and inquiry in a comprehensive and consistent manner. Present day scientific frontiers involve data collection at an ever-increasing rate. This requires that we find a way to collect the most relevant data in an automated fashion. By following the logic of the scientific method, we couple an inference engine with an inquiry engine to automate the iterative process of scientific learning. The inference engine involves Bayesian machine learning techniques to estimate model parameters based upon both prior information and previously collected data, while the inquiry engine implements data-driven exploration. By choosing an experiment whose distribution of expected results has the maximum entropy, the inquiry engine selects the experiment that maximizes the expected information gain. The coupled inference and inquiry engines constitute an autonomous learning method for scientific exploration. We apply it to a robotic arm to demonstrate the efficacy of the method. Optimizing inquiry involves searching for an experiment that promises, on average, to be maximally informative. If the set of potential experiments is described by many parameters, the search involves a high-dimensional entropy space. In such cases, a brute force search method will be slow and computationally expensive. We develop an entropy-based search algorithm, called nested entropy sampling, to select the most informative experiment. This helps to reduce the number of computations necessary to find the optimal experiment. We also extended the method of maximizing entropy, and developed a method of maximizing joint entropy so that it could be used as a principle of collaboration between two robots. This is a major achievement of this thesis, as it allows the information-based collaboration between two robotic units towards a same

  4. Comparative evaluation of ceramic bracket base designs.

    PubMed

    Bordeaux, J M; Moore, R N; Bagby, M D

    1994-06-01

    Since the initial introduction of ceramic brackets, base designs have been modified to reduce tooth damage during debonding. The purpose of this study was to compare shear and tensile bond strengths and fracture sites of four second-generation ceramic brackets: Allure IV (A) (GAC International, Inc., Central Islip, N.Y.), Ceramaflex (C) (TP Orthodontics, Inc., LaPorte, Ind.), Intrigue (I) (Lancer Orthodontics, Carlsbad, Calif.), Transcend 2000 (T) (Unitek Corp., Monrovia, Calif.), and a foil-mesh base stainless steel bracket, DynaBond II (D) (Unitek Corp., Monrovia, Calif.). Twenty brackets of each type were bonded to 100 mandibular bovine incisor teeth with Concise bonding adhesive. The samples were thermocycled for 24 hours and the brackets were debonded with an Instron universal testing machine (Instron Corp., Canton, Mass.). A modified Transcend debonding instrument was used for tensile debonding, whereas a chisel was used for shear debonding. An analysis of variance was performed with a 0.05 level of confidence. Mean shear strengths (kg/cm2) necessary to debond were 174.0 (A), 71.0 (C), 189.0 (I), 228.0 (T), and 160.0 (D). Mean tensile strengths (kg/cm2) were 27.0 (A), 26.7 (C), 51.3 (I), 56.5 (T), and 48.6 (D). Fracture sites examined with a light microscope showed no enamel damage with any of the ceramic brackets. Intrigue was the only bracket to fracture and had 30% bracket fracture in the tensile mode and 20% bracket fracture in the shear mode. The percentage of fractures at the adhesive-bracket base interface for shear and tensile modes, respectively, were 80, 100 (A); 100, 90 (C); 10, 60 (I); 60, 90 (T); and 90, 80 (D).(ABSTRACT TRUNCATED AT 250 WORDS)

  5. A User-Centered Framework for Deriving A Conceptual Design From User Experiences: Leveraging Personas and Patterns to Create Usable Designs

    NASA Astrophysics Data System (ADS)

    Javahery, Homa; Deichman, Alexander; Seffah, Ahmed; Taleb, Mohamed

    Patterns are a design tool to capture best practices, tackling problems that occur in different contexts. A user interface (UI) design pattern spans several levels of design abstraction ranging from high-level navigation to low-level idioms detailing a screen layout. One challenge is to combine a set of patterns to create a conceptual design that reflects user experiences. In this chapter, we detail a user-centered design (UCD) framework that exploits the novel idea of using personas and patterns together. Personas are used initially to collect and model user experiences. UI patterns are selected based on personas pecifications; these patterns are then used as building blocks for constructing conceptual designs. Through the use of a case study, we illustrate how personas and patterns can act as complementary techniques in narrowing the gap between two major steps in UCD: capturing users and their experiences, and building an early design based on that information. As a result of lessons learned from the study and by refining our framework, we define a more systematic process called UX-P (User Experiences to Pattern), with a supporting tool. The process introduces intermediate analytical steps and supports designers in creating usable designs.

  6. Designer: A Knowledge-Based Graphic Design Assistant.

    DTIC Science & Technology

    1986-07-01

    1983; Ching, 1979; Dondis , 1973; Hurlburt, 1977; Marcus, 1986; Reilly & Roach. 1984; Sherwood, 1981; Taylor, 1960; Wong, 1972). Unfortunately, the...informa- tion ( Dondis , 1973). These visual techniques represent a vocabulary in which to describe the design. These techniques in conjunction with the...Artificial Intelligence, 28, 197-224. Dondis , D. A. (1973). A primer of visual literacy. Cambridge, MA: MIT Press. Glenn, B. (1986). Descriptor: A model for

  7. Stratified sampling design based on data mining.

    PubMed

    Kim, Yeonkook J; Oh, Yoonhwan; Park, Sunghoon; Cho, Sungzoon; Park, Hayoung

    2013-09-01

    To explore classification rules based on data mining methodologies which are to be used in defining strata in stratified sampling of healthcare providers with improved sampling efficiency. We performed k-means clustering to group providers with similar characteristics, then, constructed decision trees on cluster labels to generate stratification rules. We assessed the variance explained by the stratification proposed in this study and by conventional stratification to evaluate the performance of the sampling design. We constructed a study database from health insurance claims data and providers' profile data made available to this study by the Health Insurance Review and Assessment Service of South Korea, and population data from Statistics Korea. From our database, we used the data for single specialty clinics or hospitals in two specialties, general surgery and ophthalmology, for the year 2011 in this study. Data mining resulted in five strata in general surgery with two stratification variables, the number of inpatients per specialist and population density of provider location, and five strata in ophthalmology with two stratification variables, the number of inpatients per specialist and number of beds. The percentages of variance in annual changes in the productivity of specialists explained by the stratification in general surgery and ophthalmology were 22% and 8%, respectively, whereas conventional stratification by the type of provider location and number of beds explained 2% and 0.2% of variance, respectively. This study demonstrated that data mining methods can be used in designing efficient stratified sampling with variables readily available to the insurer and government; it offers an alternative to the existing stratification method that is widely used in healthcare provider surveys in South Korea.

  8. Stratified Sampling Design Based on Data Mining

    PubMed Central

    Kim, Yeonkook J.; Oh, Yoonhwan; Park, Sunghoon; Cho, Sungzoon

    2013-01-01

    Objectives To explore classification rules based on data mining methodologies which are to be used in defining strata in stratified sampling of healthcare providers with improved sampling efficiency. Methods We performed k-means clustering to group providers with similar characteristics, then, constructed decision trees on cluster labels to generate stratification rules. We assessed the variance explained by the stratification proposed in this study and by conventional stratification to evaluate the performance of the sampling design. We constructed a study database from health insurance claims data and providers' profile data made available to this study by the Health Insurance Review and Assessment Service of South Korea, and population data from Statistics Korea. From our database, we used the data for single specialty clinics or hospitals in two specialties, general surgery and ophthalmology, for the year 2011 in this study. Results Data mining resulted in five strata in general surgery with two stratification variables, the number of inpatients per specialist and population density of provider location, and five strata in ophthalmology with two stratification variables, the number of inpatients per specialist and number of beds. The percentages of variance in annual changes in the productivity of specialists explained by the stratification in general surgery and ophthalmology were 22% and 8%, respectively, whereas conventional stratification by the type of provider location and number of beds explained 2% and 0.2% of variance, respectively. Conclusions This study demonstrated that data mining methods can be used in designing efficient stratified sampling with variables readily available to the insurer and government; it offers an alternative to the existing stratification method that is widely used in healthcare provider surveys in South Korea. PMID:24175117

  9. Validity, reliability, and responsiveness of the ICIQ-UI SF and ICIQ-LUTSqol in the Malaysian population.

    PubMed

    Lim, Renly; Liong, Men Long; Lau, Yong Khee; Yuen, Kah Hay

    2017-02-01

    To enable the use of the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) and ICIQ-Lower Urinary Tract Symptoms Quality of Life (ICIQ-LUTSqol) in Southeast Asia, we translated and subsequently evaluated their validity (content and discriminant validity), reliability (internal consistency and test-retest reliability), and responsiveness in female patients with stress urinary incontinence. Permission was obtained to translate the English versions into Malay and subsequently validate them, and to validate the existing Chinese versions. The translated questionnaires were taken for pilot testing. Validation was carried out for the face/content and discriminant validity. Reliability was assessed for test-retest and internal consistency using Cronbach's alpha and intraclass correlation coefficient respectively. The responsiveness was calculated via effect size and standardized response mean. Ten patients were recruited for the pilot testing. The English and Chinese versions had "substantial" or "almost perfect" agreement as measured by weighted Kappa. 284 participants (139 patients with stress urinary incontinence and 145 healthy volunteers) were included in the subsequent phases. The ICIQ-UI SF and ICIQ-LUTSqol had good discriminant validity. The ICIQ-UI SF had moderate internal consistency although the ICIQ-LUTSqol had good internal consistency. Both questionnaires had high test-retest reliability. Responsiveness was established with a moderate to large effect size and a standardized response mean. The English, Chinese, and Malay versions each proved to be valid and reliable in our Malaysian population, thereby enabling more cross-cultural research in this region. Neurourol. Neurourol. Urodynam. 36:438-442, 2017. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.

  10. Highly Sensitive and Selective Sensing of Free Bilirubin Using Metal-Organic Frameworks-Based Energy Transfer Process.

    PubMed

    Du, Yaran; Li, Xiqian; Lv, Xueju; Jia, Qiong

    2017-09-13

    Free bilirubin, a key biomarker for jaundice, was detected with a newly designed fluorescent postsynthetically modified metal organic framework (MOF) (UIO-66-PSM) sensor. UiO-66-PSM was prepared based on the aldimine condensation reaction of UiO-66-NH2 with 2,3,4-trihydroxybenzaldehyde. The fluorescence of UIO-66-PSM could be effectively quenched by free bilirubin via a fluorescent resonant energy transfer process, thus achieving its recognition of free bilirubin. It was the first attempt to design a MOF-based fluorescent probe for sensing free bilirubin. The probe exhibited fast response time, low detection limit, wide linear range, and high selectivity toward free bilirubin. The sensing system enabled the monitor of free bilirubin in real human serum. Hence, the reported free bilirubin sensing platform has potential applications for clinical diagnosis of jaundice.

  11. Simulation-based disassembly systems design

    NASA Astrophysics Data System (ADS)

    Ohlendorf, Martin; Herrmann, Christoph; Hesselbach, Juergen

    2004-02-01

    Recycling of Waste of Electrical and Electronic Equipment (WEEE) is a matter of actual concern, driven by economic, ecological and legislative reasons. Here, disassembly as the first step of the treatment process plays a key role. To achieve sustainable progress in WEEE disassembly, the key is not to limit analysis and planning to merely disassembly processes in a narrow sense, but to consider entire disassembly plants including additional aspects such as internal logistics, storage, sorting etc. as well. In this regard, the paper presents ways of designing, dimensioning, structuring and modeling different disassembly systems. Goal is to achieve efficient and economic disassembly systems that allow recycling processes complying with legal requirements. Moreover, advantages of applying simulation software tools that are widespread and successfully utilized in conventional industry sectors are addressed. They support systematic disassembly planning by means of simulation experiments including consecutive efficiency evaluation. Consequently, anticipatory recycling planning considering various scenarios is enabled and decisions about which types of disassembly systems evidence appropriateness for specific circumstances such as product spectrum, throughput, disassembly depth etc. is supported. Furthermore, integration of simulation based disassembly planning in a holistic concept with configuration of interfaces and data utilization including cost aspects is described.

  12. Tuning the Morphology and Activity of Electrospun Polystyrene/UiO-66-NH2 Metal-Organic Framework Composites to Enhance Chemical Warfare Agent Removal.

    PubMed

    Peterson, Gregory W; Lu, Annie X; Epps, Thomas H

    2017-09-20

    This work investigates the processing-structure-activity relationships that ultimately facilitate the enhanced performance of UiO-66-NH2 metal-organic frameworks (MOFs) in electrospun polystyrene (PS) fibers for chemical warfare agent detoxification. Key electrospinning processing parameters including solvent type (dimethylformamide [DMF]) vs DMF/tetrahydrofuran [THF]), PS weight fraction in solution, and MOF weight fraction relative to PS were varied to optimize MOF incorporation into the fibers and ultimately improve composite performance. It was found that composites spun from pure DMF generally resulted in MOF crystal deposition on the surface of the fibers, while composites spun from DMF/THF typically led to MOF crystal deposition within the fibers. For cases in which the MOF was incorporated on the periphery of the fibers, the composites generally demonstrated better gas uptake (e.g., nitrogen, chlorine) because of enhanced access to the MOF pores. Additionally, increasing both the polymer and MOF weight percentages in the electrospun solutions resulted in larger diameter fibers, with polymer concentration having a more pronounced effect on fiber size; however, these larger fibers were generally less efficient at gas separations. Overall, exploring the electrospinning parameter space resulted in composites that outperformed previously reported materials for the detoxification of the chemical warfare agent, soman. The data and strategies herein thus provide guiding principles applicable to the design of future systems for protection and separations as well as a wide range of environmental remediation applications.

  13. Integrating evidence-based design and experience-based approaches in healthcare service design.

    PubMed

    Carr, Valerie L; Sangiorgi, Daniela; Büscher, Monika; Junginger, Sabine; Cooper, Rachel

    2011-01-01

    To investigate the connections between, and respective contributions of, evidence-based and experience-based methods in the redesign of healthcare services. Evidence-based medicine (EBM) preceded (and inspired) the development of evidence-based design (EBD) for healthcare facilities. A key feature of debate around EBM has been the question of interpretation of the guidance by experienced clinicians, to achieve maximum efficacy for individual patients. This interpretation and translation of guidelines-avoiding a formulaic approach, allowing for divergent cultural and geographical exigencies, creating innovative, context-specific solutions-is the subject of this discussion, which examines the potential for integration of evidence-based and experience-based approaches in the development of creative solutions to healthcare services in England. This paper examines Practice-Based Commissioning (PBC) in England, which devolves responsibility for commissioning new services for patients to frontline clinicians, relying on their understanding of patient needs at the local level. An 18-month project, funded by the Health and Care Infrastructure Research and Innovation Centre (HaCIRIC), examined PBC frameworks in England, investigating the impact of different models of governance on the development of service redesign proposals to answer the following questions: How do clinicians interpret the multiplicity of guidance from government agencies and translate this into knowledge that can be effectively used to redesign patient care pathways aligned with local healthcare priorities? How can understanding patient and staff "experiences" and key "touch points" of interaction with local healthcare services be used to provide a creative, customized solution to the design of healthcare services in a local, community-based framework?

  14. Mirror-based hybrids of recent design

    NASA Astrophysics Data System (ADS)

    Moir, R. W.; Martovetsky, N. N.; Molvik, A. W.; Ryutov, Dimitri; Simonen, T. C.

    2012-06-01

    Early application of the simple axisymmetric mirror, requiring intermediate performance between a neutron source for materials testing Q=Pfusion/Pinput ˜0.05 and pure fusion Q>10, are the hybrid applications. The Axisymmetric Mirror has attractive features as a driver for a fusion-fission hybrid system: geometrical simplicity, as well as the typical mirror features of inherently steady-state operation, and natural divertors in the form of end tanks. Operation at Q˜0.7 allows for relatively low electron temperatures, in the range of 3 keV, for the DT injection energy ˜ 80 keV from existing positive ion neutral beams designed for steady state. This level of physics performance has the virtue of being low risk with only modest R&D needed; and its simplicity promises economy advantages. A simple mirror with the plasma diameter of 1 m and mirror-to-mirror 2.5 T solenoid length of 40 m is discussed. Simple circular steady state superconducting coils at each end are based on 15 T technology development of the ITER central solenoid. Hybrids obtain important revenues from the sale of both electricity and fuel production or waste burning. Burning fission reactor wastes by fissioning transuranics in the hybrid will multiply fusion's neutron energy by a factor of ˜10 or more and diminish the Q needed to overcome the cost of recirculating power for good economics to less than 2 and for minor actinides with multiplication over 50 to Q˜0.2. Hybrids that produce fissile fuel with fissioning blankets might need Q<2 while suppressing fissioning might be the most economical application of fusion but will require Q>4.

  15. Hybrid Polymer/UiO-66(Zr) and Polymer/NaY Fiber Sorbents for Mercaptan Removal from Natural Gas.

    PubMed

    Chen, Grace; Koros, William J; Jones, Christopher W

    2016-04-20

    Zeolite NaY and metal organic frameworks MIL-53(Al) and UiO-66(Zr) are spun with cellulose acetate (CA) polymer to create hybrid porous composite fibers for the selective adsorption of sulfur odorant compounds from pipeline natural gas. Odorant removal is desirable to limit corrosion associated with sulfur oxide production, thereby increasing lifetime in gas turbines used for electricity generation. In line with these goals, the performance of the hybrid fibers is evaluated on the basis of sulfur sorption capacity and selectivity, as well as fiber stability and regenerability, compared to their polymer-free sorbent counterparts. The capacities of the powder sorbents are also measured using various desorption temperatures to evaluate the potential for lower temperature, energy, and cost-efficient system operation. Both NaY/CA and UiO-66(Zr)/CA hybrid fibers are prepared with high sorbent loadings, and both have high capacities and selectivities for t-butyl mercaptan (TBM) odorant sorption from a model natural gas (NG), while being stable to multiple regeneration cycles. The different advantages and disadvantages of both types of fibers relative are discussed, with both offering the potential advantages of low pressure drop, rapid heat and mass transfer, and low energy requirements over traditional sulfur removal technologies such as hydrodesulfurization (HDS) or adsorption in a pellet packed beds.

  16. Model based design introduction: modeling game controllers to microprocessor architectures

    NASA Astrophysics Data System (ADS)

    Jungwirth, Patrick; Badawy, Abdel-Hameed

    2017-04-01

    We present an introduction to model based design. Model based design is a visual representation, generally a block diagram, to model and incrementally develop a complex system. Model based design is a commonly used design methodology for digital signal processing, control systems, and embedded systems. Model based design's philosophy is: to solve a problem - a step at a time. The approach can be compared to a series of steps to converge to a solution. A block diagram simulation tool allows a design to be simulated with real world measurement data. For example, if an analog control system is being upgraded to a digital control system, the analog sensor input signals can be recorded. The digital control algorithm can be simulated with the real world sensor data. The output from the simulated digital control system can then be compared to the old analog based control system. Model based design can compared to Agile software develop. The Agile software development goal is to develop working software in incremental steps. Progress is measured in completed and tested code units. Progress is measured in model based design by completed and tested blocks. We present a concept for a video game controller and then use model based design to iterate the design towards a working system. We will also describe a model based design effort to develop an OS Friendly Microprocessor Architecture based on the RISC-V.

  17. Protein design based on parallel dimensional reduction.

    PubMed

    Moltó, Germán; Suárez, María; Tortosa, Pablo; Alonso, José M; Hernández, Vicente; Jaramillo, Alfonso

    2009-05-01

    The design of proteins with targeted properties is a computationally intensive task with large memory requirements. We have developed a novel approach that combines a dimensional reduction of the problem with a High Performance Computing platform to efficiently design large proteins. This tool overcomes the memory limits of the process, allowing the design of proteins whose requirements prevent them to be designed in traditional sequential platforms. We have applied our algorithm to the design of functional proteins, optimizing for both catalysis and stability. We have also studied the redesign of dimerization interfaces, taking simultaneously into account the stability of the subunits of the dimer. However, our methodology can be applied to any computational chemistry application requiring combinatorial optimization techniques.

  18. UiO-66(Zr) coupled with Bi(2)MoO(6) as photocatalyst for visible-light promoted dye degradation.

    PubMed

    Ding, Jie; Yang, Zhiquan; He, Chong; Tong, Xiaowen; Li, Ying; Niu, Xiaojun; Zhang, Hongguo

    2017-07-01

    This study provides the first attempt to combine UiO-66(Zr) with Bi2MoO6 for the preparation of composite via electrostatic interaction induced self-assembly process. Synthesized products were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscope (FT-IR), X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) surface area analyse and UV-vis diffuse reflectance spectroscopy (UV-vis DRS). The photocatalytic activities of as-obtained Bi2MoO6/UiO-66(Zr) composites were assessed by degradation of Rhodamine B (Rh B) under the visible-light irradiation. Comparing to the pristine materials, the developed Bi2MoO6/UiO-66(Zr) composite with Bi:Zr molar ratio 2:1, labelled as BMUO-2, showed the best photocatalytic activity. It was supposed that the participation of Bi2MoO6 increased the use of solar energy and the existence of UiO-66(Zr) restrained the recombination rate of photo-generated electron-hole pairs. Moreover, Bi2MoO6/UiO-66(Zr) composite showed excellent stability and recyclability during cycling experiment. The mechanism and plausible pathway of Rh B degradation were also discussed in this paper. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Applying Learning Design to Work-Based Learning

    ERIC Educational Resources Information Center

    Miao, Yongwu; Hoppe, Heinz Ulrich

    2011-01-01

    Learning design is currently slanted to reflect a course-based approach to learning. This article explores whether the concept of learning design could be applied to support the informal aspects of work-based learning (WBL). It also discusses the characteristics of WBL and presents a WBL-specific learning design that highlights the key features…

  20. Design and implementation of telephone dialer based on Arduino

    NASA Astrophysics Data System (ADS)

    Ma, Zilong; Lei, Ying

    2017-03-01

    Introduces a system design scheme of the telephone dialer based on Arduino, including the design principle, hardware and software design and the experimental results in this paper. The scheme is based on the dual tone multi frequency (DTMF) dialing mode, using the Arduino UNO as the main controller, the serial port send out the telephone number to be dialed, speaker synthesize the voice.

  1. Design of control network based on OMRON PLC

    NASA Astrophysics Data System (ADS)

    Wang, Xiaocheng; Song, Xiangli; Liu, Yuan; Tang, Yuling

    2003-09-01

    This paper briefly introduces the design of control network based on OMRON PLC; and describes in detail step and setting of design based on three kinds of network: Ethernet, controller link and CompoBus/D. The design has been applied to lab construction. The practice shows that it is valuable for teaching and scientific research.

  2. Applying Learning Design to Work-Based Learning

    ERIC Educational Resources Information Center

    Miao, Yongwu; Hoppe, Heinz Ulrich

    2011-01-01

    Learning design is currently slanted to reflect a course-based approach to learning. This article explores whether the concept of learning design could be applied to support the informal aspects of work-based learning (WBL). It also discusses the characteristics of WBL and presents a WBL-specific learning design that highlights the key features…

  3. Cognitive Activity-based Design Methodology for Novice Visual Communication Designers

    ERIC Educational Resources Information Center

    Kim, Hyunjung; Lee, Hyunju

    2016-01-01

    The notion of design thinking is becoming more concrete nowadays, as design researchers and practitioners study the thinking processes involved in design and employ the concept of design thinking to foster better solutions to complex and ill-defined problems. The goal of the present research is to develop a cognitive activity-based design…

  4. Cognitive Activity-based Design Methodology for Novice Visual Communication Designers

    ERIC Educational Resources Information Center

    Kim, Hyunjung; Lee, Hyunju

    2016-01-01

    The notion of design thinking is becoming more concrete nowadays, as design researchers and practitioners study the thinking processes involved in design and employ the concept of design thinking to foster better solutions to complex and ill-defined problems. The goal of the present research is to develop a cognitive activity-based design…

  5. Ordering design tasks based on coupling strengths

    NASA Technical Reports Server (NTRS)

    Rogers, James L., Jr.; Bloebaum, Christina L.

    1994-01-01

    The design process associated with large engineering systems requires an initial decomposition of the complex system into modules of design tasks which are coupled through the transference of output data. In analyzing or optimizing such a coupled system, it is essential to be able to determine which interactions figure prominently enough to significantly affect the accuracy of the system solution. Many decomposition approaches assume the capability is available to determine what design tasks and interactions exist and what order of execution will be imposed during the analysis process. Unfortunately, this is often a complex problem and beyond the capabilities of a human design manager. A new feature for DeMAID (Design Manager's Aid for Intelligent Decomposition) will allow the design manager to use coupling strength information to find a proper sequence for ordering the design tasks. In addition, these coupling strengths aid in deciding if certain tasks or couplings could be removed (or temporarily suspended) from consideration to achieve computational savings without a significant loss of system accuracy. New rules are presented and two small test cases are used to show the effects of using coupling strengths in this manner.

  6. Ordering Design Tasks Based on Coupling Strengths

    NASA Technical Reports Server (NTRS)

    Rogers, J. L.; Bloebaum, C. L.

    1994-01-01

    The design process associated with large engineering systems requires an initial decomposition of the complex system into modules of design tasks which are coupled through the transference of output data. In analyzing or optimizing such a coupled system, it is essential to be able to determine which interactions figure prominently enough to significantly affect the accuracy of the system solution. Many decomposition approaches assume the capability is available to determine what design tasks and interactions exist and what order of execution will be imposed during the analysis process. Unfortunately, this is often a complex problem and beyond the capabilities of a human design manager. A new feature for DeMAID (Design Manager's Aid for Intelligent Decomposition) will allow the design manager to use coupling strength information to find a proper sequence for ordering the design tasks. In addition, these coupling strengths aid in deciding if certain tasks or couplings could be removed (or temporarily suspended) from consideration to achieve computational savings without a significant loss of system accuracy. New rules are presented and two small test cases are used to show the effects of using coupling strengths in this manner.

  7. An Agent-Based Intelligent CAD Platform for Collaborative Design

    NASA Astrophysics Data System (ADS)

    Liu, Quan; Cui, Xingran; Hu, Xiuyin

    Collaborative design can create added value in the design and production process by bringing the benefit of team work and cooperation in a concurrent and coordinated manner. However, distributed design knowledge and product data make the design process cumbersome. To facilitate collaborative design, an agent-based intelligent CAD platform is implemented. Intelligent agents are applied to the collaborative design. Adopting the JADE platform as framework, an intelligent collaborative design software (Co-Cad platform for short) is designed. In this platform, every man, design software, management software, equipment and resource is regarded as a single agent, the legacy design can be abstracted to be interaction between agents. Multimedia technology is integrated into Co-Cad platform, communication and identity authentication among collaborative designers from different areas are more convenient. Finally,an instance of collaborative design using Co-Cad platform is presented.

  8. Mechanical Design Support System Based on Thinking Process Development Diagram

    NASA Astrophysics Data System (ADS)

    Mase, Hisao; Kinukawa, Hiroshi; Morii, Hiroshi; Nakao, Masayuki; Hatamura, Yotaro

    This paper describes a system that directly supports a design process in a mechanical domain. This system is based on a thinking process development diagram that draws distinctions between requirement, tasks, solutions, and implementation, which enables designers to expand and deepen their thoughts of design. The system provides five main functions that designers require in each phase of the proposed design process: (1) thinking process description support which enables designers to describe their thoughts, (2) creativity support by term association with thesauri, (3) timely display of design knowledge including know-how obtained through earlier failures, general design theories, standard-parts data, and past designs, (4) design problem solving support using 46 kinds of thinking operations, and (5) proper technology transfer support which accumulates not only design conclusions but also the design process. Though this system is applied to mechanical engineering as the first target domain, it can be easily expanded to many other domains such as architecture and electricity.

  9. NGDS USER CENTERED DESIGN MEETING THE NEEDS OF THE GEOTHERMAL COMMUNITY

    SciTech Connect

    Boyd, Suzanne; Zheng, Sam Xianjun; Patten, Kim; Blackman, Harold

    2013-12-23

    In order to ensure the widest and greatest utility of IT and software projects designed for geothermal reservoir engineering the full consideration of end users’ task and workflow needs must be evaluated. This paper describes the user-centered design (UCD) approach taken in the development of a user interface (UI) solution for the National Geothermal Data System (NGDS). This development process has been researched based, highly collaborative, and incorporates state-of-the-art practices to ensure a quality user experience. Work is continuing on the interface, including future usability tests to further refine the interfaces as the overall system is developed.

  10. NGDS User Centered Design Meeting the Needs of the Geothermal Community

    SciTech Connect

    Boyd, Suzanne; Zheng, Sam; Patten, Kim; Blackman, Harold

    2013-10-15

    In order to ensure the widest and greatest utility of IT and software projects designed for geothermal reservoir engineer- ing the full consideration of end users’ task and workflow needs must be evaluated. This paper describes the user-centered design (UCD) approach taken in the development of a user interface (UI) solution for the National Geothermal Data System (NGDS). This development process has been research based, highly collabora- tive, and incorporates state-of-the-art practices to ensure a quality user experience. Work is continuing on the interface, including future usability tests to further refine the interfaces as the overall system is developed.

  11. A systems-based approach for integrated design of materials, products and design process chains

    NASA Astrophysics Data System (ADS)

    Panchal, Jitesh H.; Choi, Hae-Jin; Allen, Janet K.; McDowell, David L.; Mistree, Farrokh

    2007-12-01

    The concurrent design of materials and products provides designers with flexibility to achieve design objectives that were not previously accessible. However, the improved flexibility comes at a cost of increased complexity of the design process chains and the materials simulation models used for executing the design chains. Efforts to reduce the complexity generally result in increased uncertainty. We contend that a systems based approach is essential for managing both the complexity and the uncertainty in design process chains and simulation models in concurrent material and product design. Our approach is based on simplifying the design process chains systematically such that the resulting uncertainty does not significantly affect the overall system performance. Similarly, instead of striving for accurate models for multiscale systems (that are inherently complex), we rely on making design decisions that are robust to uncertainties in the models. Accordingly, we pursue hierarchical modeling in the context of design of multiscale systems. In this paper our focus is on design process chains. We present a systems based approach, premised on the assumption that complex systems can be designed efficiently by managing the complexity of design process chains. The approach relies on (a) the use of reusable interaction patterns to model design process chains, and (b) consideration of design process decisions using value-of-information based metrics. The approach is illustrated using a Multifunctional Energetic Structural Material (MESM) design example. Energetic materials store considerable energy which can be released through shock-induced detonation; conventionally, they are not engineered for strength properties. The design objectives for the MESM in this paper include both sufficient strength and energy release characteristics. The design is carried out by using models at different length and time scales that simulate different aspects of the system. Finally, by

  12. Designers as users - Design supports based on crew system design practices

    NASA Technical Reports Server (NTRS)

    Cody, William J.

    1989-01-01

    The behavioral processes in aviation crew system design are theoretically discussed. Interviews with designers concerning actual design experiences were conducted in a structured manner, focusing on the nature of the design problem, the designers's tasks, how decisions governing the human operator's role are made, and how this decision making can be supported. Two taxonomies emerge, one of which summarizes the nature of the design problem and the second of which summarizes the tasks that designers perform toward solving the problem. Combining the taxonomies yields a design problem space that is used to classify existing forms of support. The results of this classification and the implications for needed supports are discussed.

  13. Degradation of Paraoxon and the Chemical Warfare Agents VX, Tabun, and Soman by the Metal-Organic Frameworks UiO-66-NH2, MOF-808, NU-1000, and PCN-777.

    PubMed

    de Koning, Martijn C; van Grol, Marco; Breijaert, Troy

    2017-10-02

    In recent years, Zr-based metal-organic frameworks (MOFs) have been developed that facilitate catalytic degradation of toxic organophosphate agents, such as chemical warfare agents (CWAs). Because of strict regulations, experiments using live agents are not possible for most laboratories and, as a result, simulants are used in the majority of cases. Reports that employ real CWAs are scarce and do not cover the whole spectrum of agents. We here present a comparative study in which UiO-66-NH2, NU-1000, MOF-808, and PCN-777 are evaluated for their effectiveness in the degradation of paraoxon and the chemical warfare agents tabun, VX, and soman, in N-ethylmorpholine buffer (pH 10) as well as in pure water. All MOFs showed excellent ability to degrade the agents under basic conditions. It was further disclosed that tabun is degraded by different mechanisms depending on the conditions. The presence of an amine, either as part of the MOF structure (UiO-66-NH2) or in the agent itself (VX, tabun), is the most important factor governing degradation rates in water. The results show that MOFs have great potential in future protective applications. Although the use of simulants provides valuable information for initial screening and selection of new MOFs, the use of live agents revealed additional mechanisms that should aid the future development of even better catalysts.

  14. Gated Channels and Selectivity Tuning of CO2 over N2 Sorption by Post-Synthetic Modification of a UiO-66-Type Metal-Organic Framework.

    PubMed

    Kronast, Alexander; Eckstein, Sebastian; Altenbuchner, Peter T; Hindelang, Konrad; Vagin, Sergei I; Rieger, Bernhard

    2016-08-26

    The highly porous and stable metal-organic framework (MOF) UiO-66 was altered using post-synthetic modifications (PSMs). Prefunctionalization allowed the introduction of carbon double bonds into the framework through a four-step synthesis from 2-bromo-1,4-benzenedicarboxylic acid; the organic linker 2-allyl-1,4-benzenedicarboxylic acid was obtained. The corresponding functionalized MOF (UiO-66-allyl) served as a platform for further PSMs. From UiO-66-allyl, epoxy, dibromide, thioether, diamine, and amino alcohol functionalities were synthesized. The abilities of these compounds to adsorb CO2 and N2 were compared, which revealed the structure-selectivity correlations. All synthesized MOFs showed profound thermal stability together with an increased ability for selective CO2 uptake and molecular gate functionalities at low temperatures.

  15. Starshade design for occulter based exoplanet missions

    NASA Astrophysics Data System (ADS)

    Thomson, Mark W.; Lisman, P. Douglas; Helms, Richard; Walkemeyer, Phil; Kissil, Andrew; Polanco, Otto; Lee, Siu-Chun

    2010-07-01

    We present a lightweight starshade design that delivers the requisite profile figure accuracy with a compact stowed volume that permits launching both the occulter system (starshade and spacecraft) and a 1 to 2m-class telescope system on a single existing launch vehicle. Optimal figure stability is achieved with a very stiff and mass-efficient deployable structure design that has a novel configuration. The reference design is matched to a 1.1m telescope and consists of a 15m diameter inner disc and 24 flower-like petals with 7.5m length. The total tip-to-tip diameter of 30m provides an inner working angle of 75 mas. The design is scalable to accommodate larger telescopes and several options have been assessed. A proof of concept petal is now in production at JPL for deployment demonstrations and as a testbed for developing additional elements of the design. Future plans include developing breadboard and prototype hardware of increasing fidelity for use in demonstrating critical performance capabilities such as deployed optical edge profile figure tolerances and stability thereof.

  16. Starshade Design for Occulter Based Exoplanet Missions

    NASA Technical Reports Server (NTRS)

    Thomson, Mark W.; Lisman, P. Douglas; Helms, Richard; Walkemeyer, Phil; Kissil, Andrew; Polanco, Otto; Lee, Siu-Chun

    2010-01-01

    We present a lightweight starshade design that delivers the requisite profile figure accuracy with a compact stowed volume that permits launching both the occulter system (starshade and spacecraft) and a 1 to 2m-class telescope system on a single existing launch vehicle. Optimal figure stability is achieved with a very stiff and mass-efficient deployable structure design that has a novel configuration. The reference design is matched to a 1.1m telescope and consists of a 15m diameter inner disc and 24 flower-like petals with 7.5m length. The total tip-to-tip diameter of 30m provides an inner working angle of 75 mas. The design is scalable to accommodate larger telescopes and several options have been assessed. A proof of concept petal is now in production at JPL for deployment demonstrations and as a testbed for developing additional elements of the design. Future plans include developing breadboard and prototype hardware of increasing fidelity for use in demonstrating critical performance capabilities such as deployed optical edge profile figure tolerances and stability thereof.

  17. Starshade Design for Occulter Based Exoplanet Missions

    NASA Technical Reports Server (NTRS)

    Thomson, Mark W.; Lisman, P. Douglas; Helms, Richard; Walkemeyer, Phil; Kissil, Andrew; Polanco, Otto; Lee, Siu-Chun

    2010-01-01

    We present a lightweight starshade design that delivers the requisite profile figure accuracy with a compact stowed volume that permits launching both the occulter system (starshade and spacecraft) and a 1 to 2m-class telescope system on a single existing launch vehicle. Optimal figure stability is achieved with a very stiff and mass-efficient deployable structure design that has a novel configuration. The reference design is matched to a 1.1m telescope and consists of a 15m diameter inner disc and 24 flower-like petals with 7.5m length. The total tip-to-tip diameter of 30m provides an inner working angle of 75 mas. The design is scalable to accommodate larger telescopes and several options have been assessed. A proof of concept petal is now in production at JPL for deployment demonstrations and as a testbed for developing additional elements of the design. Future plans include developing breadboard and prototype hardware of increasing fidelity for use in demonstrating critical performance capabilities such as deployed optical edge profile figure tolerances and stability thereof.

  18. Lunar base CELSS design and analysis.

    PubMed

    Sirko, R J; Smith, G C; Hamlin, L A; Tazawa, R; Uchida, T; Suzuki, S

    1994-11-01

    This paper describes the conceptual development of a hybrid biological-physical/chemical (P/C) life support system model for a lunar outpost. It presents steps that lead to loop closure and determines mass flow characteristics for an inedible biomass enzyme reactor and an activated sludge bioreactor. Computer modeling techniques were used to determine that the cellulose reactor has the design capabilities to provide significant increases in the plant harvest index. Activated sludge was found to fit design demands for a small, continuous-flow, steady-state system. Systems analysis and component sizing for these two bioreactors and information regarding supporting bioregenerative and physical/chemical components are presented.

  19. A Web Based Collaborative Design Environment for Spacecraft

    NASA Technical Reports Server (NTRS)

    Dunphy, Julia

    1998-01-01

    In this era of shrinking federal budgets in the USA we need to dramatically improve our efficiency in the spacecraft engineering design process. We have come up with a method which captures much of the experts' expertise in a dataflow design graph: Seamlessly connectable set of local and remote design tools; Seamlessly connectable web based design tools; and Web browser interface to the developing spacecraft design. We have recently completed our first web browser interface and demonstrated its utility in the design of an aeroshell using design tools located at web sites at three NASA facilities. Multiple design engineers and managers are now able to interrogate the design engine simultaneously and find out what the design looks like at any point in the design cycle, what its parameters are, and how it reacts to adverse space environments.

  20. NUCLEAR SAFETY DESIGN BASES FOR LICENSE APPLICATION

    SciTech Connect

    R.J. Garrett

    2005-03-08

    The purpose of this report is to identify and document the nuclear safety design requirements that are specific to structures, systems, and components (SSCs) of the repository that are important to safety (ITS) during the preclosure period and to support the preclosure safety analysis and the license application for the high-level radioactive waste (HLW) repository at Yucca Mountain, Nevada. The scope of this report includes the assignment of nuclear safety design requirements to SSCs that are ITS and does not include the assignment of design requirements to SSCs or natural or engineered barriers that are important to waste isolation (ITWI). These requirements are used as input for the design of the SSCs that are ITS such that the preclosure performance objectives of 10 CFR 63.111 [DIRS 156605] are met. The natural or engineered barriers that are important to meeting the postclosure performance objectives of 10 CFR 63.113 [DIRS 156605] are identified as ITWI. Although a structure, system, or component (SSC) that is ITS may also be ITWI, this report is only concerned with providing the nuclear safety requirements for SSCs that are ITS to prevent or mitigate event sequences during the repository preclosure period.

  1. Nuclear Safety Design Base for License Application

    SciTech Connect

    R.J. Garrett

    2005-09-29

    The purpose of this report is to identify and document the nuclear safety design requirements that are specific to structures, systems, and components (SSCs) of the repository that are important to safety (ITS) during the preclosure period and to support the preclosure safety analysis and the license application for the high-level radioactive waste (HLW) repository at Yucca Mountain, Nevada. The scope of this report includes the assignment of nuclear safety design requirements to SSCs that are ITS and does not include the assignment of design requirements to SSCs or natural or engineered barriers that are important to waste isolation (ITWI). These requirements are used as input for the design of the SSCs that are ITS such that the preclosure performance objectives of 10 CFR 63.111(b) [DIRS 173273] are met. The natural or engineered barriers that are important to meeting the postclosure performance objectives of 10 CFR 63.113(b) and (c) [DIRS 173273] are identified as ITWI. Although a structure, system, or component (SSC) that is ITS may also be ITWI, this report is only concerned with providing the nuclear safety requirements for SSCs that are ITS to prevent or mitigate event sequences during the repository preclosure period.

  2. DESIGN STREAM FLOWS BASED ON HARMONIC MEANS.

    EPA Science Inventory

    Design streamflows are frequently used in water quality studies to provide adequate protection against pollutant exposure periods of a given duration. By analyzing the effect that simple streamflow dilution has on x-day average exposure levels of a pollutant, it appears that the ...

  3. The LACIE data bases: Design considerations

    NASA Technical Reports Server (NTRS)

    Westberry, L. E. (Principal Investigator)

    1979-01-01

    The implementation of direct access storage devices for LACIE is discussed with emphasis on the storage and retrieval of image data. Topics covered include the definition of the problem, the solution methodology (design decisions), the initial operational structure, and the modifications which were incorporated. Some conclusions and projections of future problems to be solved are also presented.

  4. DESIGN STREAM FLOWS BASED ON HARMONIC MEANS.

    EPA Science Inventory

    Design streamflows are frequently used in water quality studies to provide adequate protection against pollutant exposure periods of a given duration. By analyzing the effect that simple streamflow dilution has on x-day average exposure levels of a pollutant, it appears that the ...

  5. Effects of Pelletization Pressure on the Physical and Chemical Properties of the Metal-Organic Frameworks Cu3(BTC)2 and UiO-66

    DTIC Science & Technology

    2013-02-26

    testing was conducted with CuBTC against ammonia , which probes the reactive sites, and UiO-66 against octane, which probes physical adsorption capacity...Even with the decrease in surface area, the CuBTC materials had consistent ammonia removal capacities, while the UiO-66 pressed materials showed a...21010, USA cGeorgia Institute of Technology, School of Chemical & Biomolecular Engineering, Atlanta, GA 30332, USA a r t i c l e i n f o Article history

  6. UiO-66-(SH)2 as stable, selective and regenerable adsorbent for the removal of mercury from water under environmentally-relevant conditions.

    PubMed

    Leus, Karen; Perez, Jeffrey Paulo H; Folens, Karel; Meledina, Maria; Van Tendeloo, Gustaaf; Du Laing, Gijs; Van Der Voort, Pascal

    2017-09-08

    The dithiol functionalized UiO-66-(SH)2 is developed as an efficient adsorbent for the removal of mercury in aqueous media. Important parameters for the application of MOFs in real-life circumstances include: stability and recyclability of the adsorbents, selectivity for the targeted Hg species in the presence of much higher concentrations of interfering species, and ability to purify wastewater below international environmental limits within a short time. We show that UiO-66-(SH)2 meets all these criteria.

  7. EvoDesign: De novo protein design based on structural and evolutionary profiles.

    PubMed

    Mitra, Pralay; Shultis, David; Zhang, Yang

    2013-07-01

    Protein design aims to identify new protein sequences of desirable structure and biological function. Most current de novo protein design methods rely on physics-based force fields to search for low free-energy states following Anfinsen's thermodynamic hypothesis. A major obstacle of such approaches is the inaccuracy of the force field design, which cannot accurately describe the atomic interactions or distinguish correct folds. We developed a new web server, EvoDesign, to design optimal protein sequences of given scaffolds along with multiple sequence and structure-based features to assess the foldability and goodness of the designs. EvoDesign uses an evolution-profile-based Monte Carlo search with the profiles constructed from homologous structure families in the Protein Data Bank. A set of local structure features, including secondary structure, torsion angle and solvation, are predicted by single-sequence neural-network training and used to smooth the sequence motif and accommodate the physicochemical packing. The EvoDesign algorithm has been extensively tested in large-scale protein design experiments, which demonstrate enhanced foldability and structural stability of designed sequences compared with the physics-based designing methods. The EvoDesign server is freely available at http://zhanglab.ccmb.med.umich.edu/EvoDesign.

  8. Flight Software Design Choices Based on Criticality

    NASA Technical Reports Server (NTRS)

    Lee, Earl

    1999-01-01

    This slide presentation reviews the rationale behind flight software design as a function of criticality. The requirements of human rated systems implies a high criticality for the flight support software. Human life is dependent on correct operation of the software. Flexibility should be permitted when the consequences of software failure are not life threatening. This is also relevant for selecting Commercial Off the Shelf (COTS) software.

  9. Center for Design-Based STEM Education

    DTIC Science & Technology

    2013-10-31

    ONR grant, NYSCI will conclude its Design Lab work. Among other things, we will (1) engage another 36 middle- and elementary - school teachers in our...education strategy that has been proven to effectively engage a broad constituency in STEM. STEM (Science, Technology, Engineering, and Math); Education...Number: N00014-11-1-0957 Project Manager : Peggy Monahan Exhibit Projects Creative Director (718)699-0005 ext. 605 Contact: Lee Livney Director

  10. Finite element based electric motor design optimization

    NASA Technical Reports Server (NTRS)

    Campbell, C. Warren

    1993-01-01

    The purpose of this effort was to develop a finite element code for the analysis and design of permanent magnet electric motors. These motors would drive electromechanical actuators in advanced rocket engines. The actuators would control fuel valves and thrust vector control systems. Refurbishing the hydraulic systems of the Space Shuttle after each flight is costly and time consuming. Electromechanical actuators could replace hydraulics, improve system reliability, and reduce down time.

  11. Evidence-based long term care design.

    PubMed

    Calkins, Margaret P

    2009-01-01

    Research on the impact of the built environment in long-term care settings continues to grow. This article focuses on work conducted and published since 2000, when an earlier review on research on dementia and design was published. The vast majority of research that addressed neurological conditions in residents in long-term care settings (assisted living and nursing homes) relates to Alzheimer's disease and related dementias.

  12. Sequential experimental design based generalised ANOVA

    SciTech Connect

    Chakraborty, Souvik Chowdhury, Rajib

    2016-07-15

    Over the last decade, surrogate modelling technique has gained wide popularity in the field of uncertainty quantification, optimization, model exploration and sensitivity analysis. This approach relies on experimental design to generate training points and regression/interpolation for generating the surrogate. In this work, it is argued that conventional experimental design may render a surrogate model inefficient. In order to address this issue, this paper presents a novel distribution adaptive sequential experimental design (DA-SED). The proposed DA-SED has been coupled with a variant of generalised analysis of variance (G-ANOVA), developed by representing the component function using the generalised polynomial chaos expansion. Moreover, generalised analytical expressions for calculating the first two statistical moments of the response, which are utilized in predicting the probability of failure, have also been developed. The proposed approach has been utilized in predicting probability of failure of three structural mechanics problems. It is observed that the proposed approach yields accurate and computationally efficient estimate of the failure probability.

  13. Sequential experimental design based generalised ANOVA

    NASA Astrophysics Data System (ADS)

    Chakraborty, Souvik; Chowdhury, Rajib

    2016-07-01

    Over the last decade, surrogate modelling technique has gained wide popularity in the field of uncertainty quantification, optimization, model exploration and sensitivity analysis. This approach relies on experimental design to generate training points and regression/interpolation for generating the surrogate. In this work, it is argued that conventional experimental design may render a surrogate model inefficient. In order to address this issue, this paper presents a novel distribution adaptive sequential experimental design (DA-SED). The proposed DA-SED has been coupled with a variant of generalised analysis of variance (G-ANOVA), developed by representing the component function using the generalised polynomial chaos expansion. Moreover, generalised analytical expressions for calculating the first two statistical moments of the response, which are utilized in predicting the probability of failure, have also been developed. The proposed approach has been utilized in predicting probability of failure of three structural mechanics problems. It is observed that the proposed approach yields accurate and computationally efficient estimate of the failure probability.

  14. Growth and longevity of the cui-ui and longevity of other catostomids and cyprinids in western North America

    USGS Publications Warehouse

    Scoppettone, G.G.; Coleman, M.E.

    1988-01-01

    Annulus formation on opercula of the cui-ui Chasmistes cujus in Pyramid Lake, Nevada, was validated over an 8-year interval. Many fish were old, as old as 41 years of age, As many as three annuli were hidden (covered by supporting bone) in older fish. Growth was rapid during the first 10 years, slow from 10 to 20 years, and extremely slow or nil after 20 years. Age and growth were strongly correlated for about the first 10 years of life, but less so when fish became sexually mature. Examination of opercula of 15 additional species of large catostomids and cyprinids of western North America revealed that they were older than had previously been thought.

  15. Using Evidence-Based Design to Improve Pharmacy Department Efficiency.

    PubMed

    Greenroyd, Fraser L; Hayward, Rebecca; Price, Andrew; Demian, Peter; Sharma, Shrikant

    2016-10-01

    Using a case study of a pharmacy department rebuild in the South West of England, this article examines the use of evidence-based design to improve the efficiency and staff well-being with a new design. This article compares three designs, the current design, an anecdotal design, and an evidence-based design, to identify how evidence-based design can improve efficiency and staff well-being by reducing walking time and distance. Data were collected from the existing building and used to measure the efficiency of the department in its current state. These data were then mapped onto an anecdotal design, produced by architects from interviews and workshops with the end users, and an evidence-based design, produced by highlighting functions with high adjacencies. This changed the view on the working processes within the department, shifting away from a focus on the existing robotic dispensing system. Using evidence-based design was found to decrease the walking time and distance for staff by 24%, as opposed to the anecdotal design, which increased these parameters by 9%, and is predicted to save the department 248 min across 2 days in staff time spent walking. © The Author(s) 2016.

  16. Advanced alloy design technique: High temperature cobalt base superalloy

    NASA Technical Reports Server (NTRS)

    Dreshfield, R. L.; Freche, J. C.; Sandrock, G. D.

    1972-01-01

    Advanced alloy design technique was developed for treating alloys that will have extended life in service at high temperature and intermediate temperatures. Process stabilizes microstructure of the alloy by designing it so that compound identified with embrittlement is eliminated or minimized. Design process is being used to develop both nickel and cobalt-base superalloys.

  17. Design considerations for lunar base photovoltaic power systems

    NASA Technical Reports Server (NTRS)

    Hickman, J. Mark; Curtis, Henry B.; Landis, Geoffrey A.

    1990-01-01

    A survey was made of factors that may affect the design of photovoltaic arrays for a lunar base. These factors, which include the lunar environment and system design criteria, are examined. A photovoltaic power system design with a triangular array geometry is discussed and compared to a nuclear reactor power systems and a power system utilizing both nuclear and solar power sources.

  18. Developing Spanish Online Readings Using Design-Based Research

    ERIC Educational Resources Information Center

    Pardo-Ballester, Cristina; Rodriguez, Julio Cesar

    2010-01-01

    This article reports on the use of design-based research (DBR) in the development of online reading materials for beginning and intermediate Spanish learners. The report focuses on four studies of two main aspects of the development, namely, interface design and learner perceptions. The discussion of interface design includes the analysis of…

  19. Design considerations for lunar base photovoltaic power systems

    NASA Technical Reports Server (NTRS)

    Hickman, J. M.; Curtis, Henry B.; Landis, Geoffrey A.

    1990-01-01

    A survey was made of factors that may affect the design of photovoltaic arrays for a lunar base. These factors, which include the lunar environment and system design criteria, are examined. A photovoltaic power system design with a triangular array geometry is discussed and compared to a nuclear reactor power system and a power system utilizing both nuclear and solar power sources.

  20. Interface Design in Computer-Based Language Testing.

    ERIC Educational Resources Information Center

    Fulcher, Glenn

    2003-01-01

    Describes a three-phase process model for interface design, drawing on practices developed in the software industry and adapting them for computer-based languages tests. Describes good practice in initial design, emphasizes the importance of usability testing, and argues that only through following a principled approach to interface design can the…

  1. Developing Spanish Online Readings Using Design-Based Research

    ERIC Educational Resources Information Center

    Pardo-Ballester, Cristina; Rodriguez, Julio Cesar

    2010-01-01

    This article reports on the use of design-based research (DBR) in the development of online reading materials for beginning and intermediate Spanish learners. The report focuses on four studies of two main aspects of the development, namely, interface design and learner perceptions. The discussion of interface design includes the analysis of…

  2. Preparing Instructional Designers for Game-Based Learning: Part III. Game Design as a Collaborative Process

    ERIC Educational Resources Information Center

    Hirumi, Atsusi; Appelman, Bob; Rieber, Lloyd; Van Eck, Richard

    2010-01-01

    In this three part series, four professors who teach graduate level courses on the design of instructional video games discuss their perspectives on preparing instructional designers to optimize game-based learning. Part I set the context for the series and one of four panelists discussed what he believes instructional designers should know about…

  3. Design-Based Research: Designing a Multimedia Environment to Support Language Learning

    ERIC Educational Resources Information Center

    Hung, Hsiu-Ting

    2011-01-01

    The present study examined 89 English language learners' experiences of reflective tasks in three systematically designed courses. Adopting a design-based research method, the purpose of this paper was to investigate a pedagogical design with a focus on tailoring digital video technology to support reflective tasks for language learning in…

  4. Reflection: Research by Design: Design-Based Research and the Higher Degree Research Student

    ERIC Educational Resources Information Center

    Kennedy-Clark, Shannon

    2015-01-01

    The article "Research by design: Design-based research and the higher degree research student" (Kennedy-Clark, 2013) appeared in the "Journal of Learning Design" Volume 6, Issue 2 in 2013. Two years on, Shannon Kennedy-Clark reflects upon her original article. Upon being asked to revisit this article the author reflected upon…

  5. Preparing Instructional Designers for Game-Based Learning: Part III. Game Design as a Collaborative Process

    ERIC Educational Resources Information Center

    Hirumi, Atsusi; Appelman, Bob; Rieber, Lloyd; Van Eck, Richard

    2010-01-01

    In this three part series, four professors who teach graduate level courses on the design of instructional video games discuss their perspectives on preparing instructional designers to optimize game-based learning. Part I set the context for the series and one of four panelists discussed what he believes instructional designers should know about…

  6. Research on Reusable Design Information of Shoes Based on CBR

    NASA Astrophysics Data System (ADS)

    Li-Xia, Shi; Wen-Li, Peng; Wen-Ni, Zhang

    A way of reusing and retrieving design information of shoes using case based reasoning (CBR) in area of knowledge based engineering was presented, and a new system for reusing design information had been created. The system and CBR inference engine were introduced. It emphasized the knowledge expression of mold cases by level decomposition tree description, a way of measure similarity between the design cases and problem requirement by the fuzzy comprehensive evaluation, and the way of reusing and retrieving design information of shoes. This way was verified by the design case of casual shoes in the end.

  7. Definition of Design Case Similarity Based on Physical Quantities and Terms for Engineering Design Aid

    NASA Astrophysics Data System (ADS)

    Murakami, Tamotsu; Shimamura, Jun; Nakajima, Naomasa

    This paper proposes computerized methods of case-based design aid using similarity and relevance between design cases. First, we introduce methods of describing and recording design cases and design modification cases by physical quantities and their calculations to represent physical phenomena and terms to explain them. Then, we introduce a quantity dimension space defined by nine fundamental and supplementary quantities in SI. In quantity dimension space, a distance between physical quantities is mathematically defined based on city-block distance, and then physical quantity similarity by dimension is defined using the physical quantity distance. Then, similarity between physical quantities is defined by combining the similarity by dimension and similarity of quantity calculation structures. Also, similarity between terms is defined by combining literal similarity and cooccurrence statistics. Finally, similarity between design (modification) cases is defined based on physical quantity similarity and term similarity. By using design case similarity, designers can retrieve and consult the similar or relevant cases to a new design problem in a design case library. Also, design modification knowledge such as “which physical quantity or design parameter should be modified to solve specific trouble” can be extracted by analyzing recorded design modification cases and clustering them using design (modification) case similarity. The proposed methods are implemented as a Lisp program and are examined through some examples.

  8. Design Concepts for Data Base Utilities.

    DTIC Science & Technology

    1986-04-01

    J DESIGN CONCEPTS FOR DATABASE UTILITIES FINAL REPORT - Subsystem 2: VAL IDATE- TOKENI ZED-QUERY Data Data Source Destination ~’ Flow Item Function...Data-Node 6. / Data-Node-to-Dl*7 I Dl*-to-D2Q8 Dl*-to-D1*9 D2Q-to-Dl 10 Dl-to-User-Node 1 Shared-data-description- tokeni zed-query 13 intermediate...ari thmetic-expression tokenized-unary-boolean-expression not-operator tokenized-expression . tokenized-binary-boolean-expression .* tokeni zed

  9. Controller design approach based on linear programming.

    PubMed

    Tanaka, Ryo; Shibasaki, Hiroki; Ogawa, Hiromitsu; Murakami, Takahiro; Ishida, Yoshihisa

    2013-11-01

    This study explains and demonstrates the design method for a control system with a load disturbance observer. Observer gains are determined by linear programming (LP) in terms of the Routh-Hurwitz stability criterion and the final-value theorem. In addition, the control model has a feedback structure, and feedback gains are determined to be the linear quadratic regulator. The simulation results confirmed that compared with the conventional method, the output estimated by our proposed method converges to a reference input faster when a load disturbance is added to a control system. In addition, we also confirmed the effectiveness of the proposed method by performing an experiment with a DC motor.

  10. Process-based design of dynamical biological systems

    PubMed Central

    Tanevski, Jovan; Todorovski, Ljupčo; Džeroski, Sašo

    2016-01-01

    The computational design of dynamical systems is an important emerging task in synthetic biology. Given desired properties of the behaviour of a dynamical system, the task of design is to build an in-silico model of a system whose simulated be- haviour meets these properties. We introduce a new, process-based, design methodology for addressing this task. The new methodology combines a flexible process-based formalism for specifying the space of candidate designs with multi-objective optimization approaches for selecting the most appropriate among these candidates. We demonstrate that the methodology is general enough to both formulate and solve tasks of designing deterministic and stochastic systems, successfully reproducing plausible designs reported in previous studies and proposing new designs that meet the design criteria, but have not been previously considered. PMID:27686219

  11. Process-based design of dynamical biological systems

    NASA Astrophysics Data System (ADS)

    Tanevski, Jovan; Todorovski, Ljupčo; Džeroski, Sašo

    2016-09-01

    The computational design of dynamical systems is an important emerging task in synthetic biology. Given desired properties of the behaviour of a dynamical system, the task of design is to build an in-silico model of a system whose simulated be- haviour meets these properties. We introduce a new, process-based, design methodology for addressing this task. The new methodology combines a flexible process-based formalism for specifying the space of candidate designs with multi-objective optimization approaches for selecting the most appropriate among these candidates. We demonstrate that the methodology is general enough to both formulate and solve tasks of designing deterministic and stochastic systems, successfully reproducing plausible designs reported in previous studies and proposing new designs that meet the design criteria, but have not been previously considered.

  12. Case-based reasoning in design: An apologia

    NASA Technical Reports Server (NTRS)

    Pulaski, Kirt

    1990-01-01

    Three positions are presented and defended: the process of generating solutions in problem solving is viewable as a design task; case-based reasoning is a strong method of problem solving; and a synergism exists between case-based reasoning and design problem solving.

  13. Implementing Project Based Learning Approach to Graphic Design Course

    ERIC Educational Resources Information Center

    Riyanti, Menul Teguh; Erwin, Tuti Nuriah; Suriani, S. H.

    2017-01-01

    The purpose of this study was to develop a learning model based Commercial Graphic Design Drafting project-based learning approach, was chosen as a strategy in the learning product development research. University students as the target audience of this model are the students of the fifth semester Visual Communications Design Studies Program…

  14. Adapting Cognitive Walkthrough to Support Game Based Learning Design

    ERIC Educational Resources Information Center

    Farrell, David; Moffat, David C.

    2014-01-01

    For any given Game Based Learning (GBL) project to be successful, the player must learn something. Designers may base their work on pedagogical research, but actual game design is still largely driven by intuition. People are famously poor at unsupported methodical thinking and relying so much on instinct is an obvious weak point in GBL design…

  15. Adapting Cognitive Walkthrough to Support Game Based Learning Design

    ERIC Educational Resources Information Center

    Farrell, David; Moffat, David C.

    2014-01-01

    For any given Game Based Learning (GBL) project to be successful, the player must learn something. Designers may base their work on pedagogical research, but actual game design is still largely driven by intuition. People are famously poor at unsupported methodical thinking and relying so much on instinct is an obvious weak point in GBL design…

  16. Issues in Text Design and Layout for Computer Based Communications.

    ERIC Educational Resources Information Center

    Andresen, Lee W.

    1991-01-01

    Discussion of computer-based communications (CBC) focuses on issues involved with screen design and layout for electronic text, based on experiences with electronic messaging, conferencing, and publishing within the Australian Open Learning Information Network (AOLIN). Recommendations for research on design and layout for printed text are also…

  17. m-LoCoS UI: A Universal Visible Language for Global Mobile Communication

    NASA Astrophysics Data System (ADS)

    Marcus, Aaron

    The LoCoS universal visible language developed by the graphic/sign designer Yukio Ota in Japan in 1964 may serve as a usable, useful, and appealing basis for a mobile phone application that can provide capabilities for communication and storytelling among people who do not share a spoken language. User-interface design issues including display and input are discussed in conjunction with prototype screens showing the use of LoCoS for a mobile phone.

  18. Preliminary Helicopter Design Decision Making Based on Flight Performance Factors.

    DTIC Science & Technology

    1984-09-01

    7 AD-Aib 488 PRELIMINRY HELICOPTER DESIGN DECISION MKING BSED ON i’.. FLIGHT PERFORMAiNCE FACTOR (U) NAiVAL POSTGRADUATE SCHOOLMONTEREY CA P Y ADAMCIK...California II 00 THESIS PRELIMINARY HELICOPTER DESIGN DECISION MAKING BASED ON FLIGHT PERFORMANCE FACTORS by liELECTE D Patrick V. Adamcik LJ September 1984...TITLE (end Subtite) 5. TYPE OF REPORT & PERIOD COVERED Preliminary Helicopter Design Decision Master’s Thesis Making Based on Flight Performance

  19. Designing for Interaction: Six Steps to Designing Computer-Supported Group-Based Learning

    ERIC Educational Resources Information Center

    Strijbos, J. W.; Martens, R. L.; Jochems, W. M. G.

    2004-01-01

    At present, the design of computer-supported group-based learning (CSGBL) is often based on subjective decisions regarding tasks, pedagogy and technology, or concepts such as "cooperative learning" and "collaborative learning." Critical review reveals these concepts as insufficiently substantial to serve as a basis for CSGBL design. Furthermore,…

  20. Models of an Integrated Design Data Base in Support of a Design Automation System.

    DTIC Science & Technology

    1982-12-01

    Glossary of Terms....................161 C. Questionnaire.......................163 D. Software Engineering Tools ad Tecniques 16 Vita...independence is to clearly differentiate between the logical and physical aspects of data base management . These differ- ences include data base design...applications so that the complexity of the design and verification tasks is reduced to a manageable level. Large amounts of data and a variety of design

  1. Model-Based Design of Biochemical Microreactors.

    PubMed

    Elbinger, Tobias; Gahn, Markus; Neuss-Radu, Maria; Hante, Falk M; Voll, Lars M; Leugering, Günter; Knabner, Peter

    2016-01-01

    Mathematical modeling of biochemical pathways is an important resource in Synthetic Biology, as the predictive power of simulating synthetic pathways represents an important step in the design of synthetic metabolons. In this paper, we are concerned with the mathematical modeling, simulation, and optimization of metabolic processes in biochemical microreactors able to carry out enzymatic reactions and to exchange metabolites with their surrounding medium. The results of the reported modeling approach are incorporated in the design of the first microreactor prototypes that are under construction. These microreactors consist of compartments separated by membranes carrying specific transporters for the input of substrates and export of products. Inside the compartments of the reactor multienzyme complexes assembled on nano-beads by peptide adapters are used to carry out metabolic reactions. The spatially resolved mathematical model describing the ongoing processes consists of a system of diffusion equations together with boundary and initial conditions. The boundary conditions model the exchange of metabolites with the neighboring compartments and the reactions at the surface of the nano-beads carrying the multienzyme complexes. Efficient and accurate approaches for numerical simulation of the mathematical model and for optimal design of the microreactor are developed. As a proof-of-concept scenario, a synthetic pathway for the conversion of sucrose to glucose-6-phosphate (G6P) was chosen. In this context, the mathematical model is employed to compute the spatio-temporal distributions of the metabolite concentrations, as well as application relevant quantities like the outflow rate of G6P. These computations are performed for different scenarios, where the number of beads as well as their loading capacity are varied. The computed metabolite distributions show spatial patterns, which differ for different experimental arrangements. Furthermore, the total output of G6P

  2. Model-Based Design of Biochemical Microreactors

    PubMed Central

    Elbinger, Tobias; Gahn, Markus; Neuss-Radu, Maria; Hante, Falk M.; Voll, Lars M.; Leugering, Günter; Knabner, Peter

    2016-01-01

    Mathematical modeling of biochemical pathways is an important resource in Synthetic Biology, as the predictive power of simulating synthetic pathways represents an important step in the design of synthetic metabolons. In this paper, we are concerned with the mathematical modeling, simulation, and optimization of metabolic processes in biochemical microreactors able to carry out enzymatic reactions and to exchange metabolites with their surrounding medium. The results of the reported modeling approach are incorporated in the design of the first microreactor prototypes that are under construction. These microreactors consist of compartments separated by membranes carrying specific transporters for the input of substrates and export of products. Inside the compartments of the reactor multienzyme complexes assembled on nano-beads by peptide adapters are used to carry out metabolic reactions. The spatially resolved mathematical model describing the ongoing processes consists of a system of diffusion equations together with boundary and initial conditions. The boundary conditions model the exchange of metabolites with the neighboring compartments and the reactions at the surface of the nano-beads carrying the multienzyme complexes. Efficient and accurate approaches for numerical simulation of the mathematical model and for optimal design of the microreactor are developed. As a proof-of-concept scenario, a synthetic pathway for the conversion of sucrose to glucose-6-phosphate (G6P) was chosen. In this context, the mathematical model is employed to compute the spatio-temporal distributions of the metabolite concentrations, as well as application relevant quantities like the outflow rate of G6P. These computations are performed for different scenarios, where the number of beads as well as their loading capacity are varied. The computed metabolite distributions show spatial patterns, which differ for different experimental arrangements. Furthermore, the total output of G6P

  3. Embracing model-based designs for dose-finding trials

    PubMed Central

    Love, Sharon B; Brown, Sarah; Weir, Christopher J; Harbron, Chris; Yap, Christina; Gaschler-Markefski, Birgit; Matcham, James; Caffrey, Louise; McKevitt, Christopher; Clive, Sally; Craddock, Charlie; Spicer, James; Cornelius, Victoria

    2017-01-01

    Background: Dose-finding trials are essential to drug development as they establish recommended doses for later-phase testing. We aim to motivate wider use of model-based designs for dose finding, such as the continual reassessment method (CRM). Methods: We carried out a literature review of dose-finding designs and conducted a survey to identify perceived barriers to their implementation. Results: We describe the benefits of model-based designs (flexibility, superior operating characteristics, extended scope), their current uptake, and existing resources. The most prominent barriers to implementation of a model-based design were lack of suitable training, chief investigators’ preference for algorithm-based designs (e.g., 3+3), and limited resources for study design before funding. We use a real-world example to illustrate how these barriers can be overcome. Conclusions: There is overwhelming evidence for the benefits of CRM. Many leading pharmaceutical companies routinely implement model-based designs. Our analysis identified barriers for academic statisticians and clinical academics in mirroring the progress industry has made in trial design. Unified support from funders, regulators, and journal editors could result in more accurate doses for later-phase testing, and increase the efficiency and success of clinical drug development. We give recommendations for increasing the uptake of model-based designs for dose-finding trials in academia. PMID:28664918

  4. Designing and conducting simulation-based research.

    PubMed

    Cheng, Adam; Auerbach, Marc; Hunt, Elizabeth A; Chang, Todd P; Pusic, Martin; Nadkarni, Vinay; Kessler, David

    2014-06-01

    As simulation is increasingly used to study questions pertaining to pediatrics, it is important that investigators use rigorous methods to conduct their research. In this article, we discuss several important aspects of conducting simulation-based research in pediatrics. First, we describe, from a pediatric perspective, the 2 main types of simulation-based research: (1) studies that assess the efficacy of simulation as a training methodology and (2) studies where simulation is used as an investigative methodology. We provide a framework to help structure research questions for each type of research and describe illustrative examples of published research in pediatrics using these 2 frameworks. Second, we highlight the benefits of simulation-based research and how these apply to pediatrics. Third, we describe simulation-specific confounding variables that serve as threats to the internal validity of simulation studies and offer strategies to mitigate these confounders. Finally, we discuss the various types of outcome measures available for simulation research and offer a list of validated pediatric assessment tools that can be used in future simulation-based studies. Copyright © 2014 by the American Academy of Pediatrics.

  5. Designing Personalization in Technology-Based Services

    ERIC Educational Resources Information Center

    Lee, Min Kyung

    2013-01-01

    Personalization technology has the potential to optimize service for each person's unique needs and characteristics. One way to optimize service is to allow people to customize the service themselves; another is to proactively tailor services based on information provided by people or inferred from their past behaviors. These approaches function…

  6. Designing Personalization in Technology-Based Services

    ERIC Educational Resources Information Center

    Lee, Min Kyung

    2013-01-01

    Personalization technology has the potential to optimize service for each person's unique needs and characteristics. One way to optimize service is to allow people to customize the service themselves; another is to proactively tailor services based on information provided by people or inferred from their past behaviors. These approaches function…

  7. Case-Based Capture and Reuse of Aerospace Design Rationale

    NASA Technical Reports Server (NTRS)

    Leake, David B.

    2001-01-01

    The goal of this project was to apply artificial intelligence techniques to facilitate capture and reuse of aerospace design rationale. The project combined case-based reasoning (CBR) and concept maps (CMaps) to develop methods for capturing, organizing, and interactively accessing records of experiences encapsulating the methods and rationale underlying expert aerospace design, in order to bring the captured knowledge to bear to support future reasoning. The project's results contribute both principles and methods for effective design-aiding systems that aid capture and access of useful design knowledge. The project has been guided by the tenets that design-aiding systems must: (1) Leverage a designer's knowledge, rather than attempting to replace it; (2) Be able to reflect different designers' differing conceptualizations of the design task, and to clarify those conceptualizations to others; (3) Include capabilities to capture information both by interactive knowledge modeling and during normal use; and (4) Integrate into normal designer tasks as naturally and unobtrusive as possible.

  8. Self-Employment Programs: A New Reemployment Strategy, Final Report on the UI Self-Employment Demonstration. Unemployment Insurance Occasional Paper 95-4.

    ERIC Educational Resources Information Center

    Benus, Jacob M.; And Others

    The main parameters of state self-employment assistance (SEA) programs for unemployed workers were tested in two experimental demonstrations authorized by the North American Free Trade Agreement Implementation Act. The Washington State and Massachusetts Unemployment Insurance (UI) Self-Employment Demonstrations evaluated the ability of the…

  9. High gas storage capacities and stepwise adsorption in a UiO type metal-organic framework incorporating Lewis basic bipyridyl sites.

    PubMed

    Li, Liangjun; Tang, Sifu; Wang, Chao; Lv, Xiaoxia; Jiang, Min; Wu, Huaizhi; Zhao, Xuebo

    2014-03-04

    A UiO type MOF with Lewis basic bipyridyl sites was synthesized and structurally characterized. After being activated by Soxhlet-extraction, this MOF exhibits high storage capacities for H2, CH4 and CO2, and shows unusual stepwise adsorption for liquid CO2 and solvents, indicating a sequential filling mechanism on different adsorption sites.

  10. One-pot synthesis of binary metal organic frameworks (HKUST-1 and UiO-66) for enhanced adsorptive removal of water contaminants.

    PubMed

    Azhar, Muhammad Rizwan; Abid, Hussein Rasool; Sun, Hongqi; Periasamy, Vijay; Tadé, Moses O; Wang, Shaobin

    2017-03-15

    In this study, binary metal organic frameworks (MOFs) with HKUST-1 and UiO-66 have been synthesized in a one-pot process. The synthesized MOFs were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), N2 adsorption, and thermogravimetric analysis (TGA). The meso-porosity and thermal stability of the binary MOFs were higher than those of single HKUST-1 or UiO-66. The synthesized MOF hybrids were then tested for adsorptive removal of methylene blue (MB) from wastewater in terms of kinetic and isothermal adsorption as compared to a commercially available activated carbon (AC). All the synthesized MOFs showed significant removal of MB under a wide range of pH. The adsorption capacities of HKUST-1 are higher than UiO-66 and commercial AC while the binary MOFs presented an even higher adsorption capacity than single MOFs. This is the first time that binary HKUST-1 and UiO-66 MOFs have been successfully synthesized and demonstrated enhanced adsorptive removal of contaminants. Copyright © 2016 Elsevier Inc. All rights reserved.

  11. Ruthenium(II) Complex Incorporated UiO-67 Metal-Organic Framework Nanoparticles for Enhanced Two-Photon Fluorescence Imaging and Photodynamic Cancer Therapy.

    PubMed

    Chen, Rui; Zhang, Jinfeng; Chelora, Jipsa; Xiong, Yuan; Kershaw, Stephen V; Li, King Fai; Lo, Pik-Kwan; Cheah, Kok Wai; Rogach, Andrey L; Zapien, Juan Antonio; Lee, Chun-Sing

    2017-02-22

    Ruthenium(II) tris(bipyridyl) cationic complex (Ru(bpy)3(2+)) incorporated UiO-67 (Universitetet i Oslo) nanoscale metal-organic frameworks (NMOFs) with an average diameter of ∼92 nm were developed as theranostic nanoplatform for in vitro two-photon fluorescence imaging and photodynamic therapy. After incorporation into porous UiO-67 nanoparticles, the quantum yield, luminescence lifetime, and two-photon fluorescence intensity of Ru(bpy)3(2+) guest molecules were much improved owing to the steric confinement effect of MOF pores. Benefiting from these merits, the as-synthesized nanoparticles managed to be internalized by A549 cells while providing excellent red fluorescence in cytoplasm upon excitation with 880 nm irradiation. Photodynamic therapeutic application of the Ru(bpy)3(2+)-incorporated UiO-67 NMOFs was investigated in vitro. The Ru(bpy)3(2+)-incorporated UiO-67 NMOFs exhibited good biocompatibility without irradiation while having good cell-killing rates upon irradiation. In view of these facts, the developed Ru(bpy)3(2+)-incorporated NMOFs give a new potential pathway to achieve enhanced two-photon fluorescence imaging and photodynamic therapy.

  12. In situ energy-dispersive X-ray diffraction for the synthesis optimization and scale-up of the porous zirconium terephthalate UiO-66.

    PubMed

    Ragon, Florence; Horcajada, Patricia; Chevreau, Hubert; Hwang, Young Kyu; Lee, U-Hwang; Miller, Stuart R; Devic, Thomas; Chang, Jong-San; Serre, Christian

    2014-03-03

    The synthesis optimization and scale-up of the benchmarked microporous zirconium terephthalate UiO-66(Zr) were investigated by evaluating the impact of several parameters (zirconium precursors, acidic conditions, addition of water, and temperature) over the kinetics of crystallization by time-resolved in situ energy-dispersive X-ray diffraction. Both the addition of hydrochloric acid and water were found to speed up the reaction. The use of the less acidic ZrOCl2·8H2O as the precursor seemed to be a suitable alternative to ZrCl4·xH2O, avoiding possible reproducibility issues as a consequence of the high hygroscopic character of ZrCl4. ZrOCl2·8H2O allowed the formation of smaller good quality UiO-66(Zr) submicronic particles, paving the way for their use within the nanotechnology domain, in addition to higher reaction yields, which makes this synthesis route suitable for the preparation of UiO-66(Zr) at a larger scale. In a final step, UiO-66(Zr) was prepared using conventional reflux conditions at the 0.5 kg scale, leading to a rather high space-time yield of 490 kg m(-3) day(-1), while keeping physicochemical properties similar to those obtained from smaller scale solvothermally prepared batches.

  13. A bootstrap lunar base: Preliminary design review 2

    NASA Technical Reports Server (NTRS)

    1987-01-01

    A bootstrap lunar base is the gateway to manned solar system exploration and requires new ideas and new designs on the cutting edge of technology. A preliminary design for a Bootstrap Lunar Base, the second provided by this contractor, is presented. An overview of the work completed is discussed as well as the technical, management, and cost strategies to complete the program requirements. The lunar base design stresses the transforming capabilities of its lander vehicles to aid in base construction. The design also emphasizes modularity and expandability in the base configuration to support the long-term goals of scientific research and profitable lunar resource exploitation. To successfully construct, develop, and inhabit a permanent lunar base, however, several technological advancements must first be realized. Some of these technological advancements are also discussed.

  14. Development of a Design-Based Learning Curriculum through Design-Based Research for a Technology-Enabled Science Classroom

    ERIC Educational Resources Information Center

    Kim, Paul; Suh, Esther; Song, Donggil

    2015-01-01

    This exploratory study provides a deeper look into the aspects of students' experience from design-based learning (DBL) activities for fifth grade students. Using design-based research (DBR), this study was conducted on a series of science learning activities leveraging mobile phones with relevant applications and sensors. We observed 3 different…

  15. Development of a Design-Based Learning Curriculum through Design-Based Research for a Technology-Enabled Science Classroom

    ERIC Educational Resources Information Center

    Kim, Paul; Suh, Esther; Song, Donggil

    2015-01-01

    This exploratory study provides a deeper look into the aspects of students' experience from design-based learning (DBL) activities for fifth grade students. Using design-based research (DBR), this study was conducted on a series of science learning activities leveraging mobile phones with relevant applications and sensors. We observed 3 different…

  16. Data base design for a worldwide multicrop information system

    NASA Technical Reports Server (NTRS)

    Driggers, W. G.; Downs, J. M.; Hickman, J. R.; Packard, R. L. (Principal Investigator)

    1979-01-01

    A description of the USDA Application Test System data base design approach and resources is presented. The data is described in detail by category, with emphasis on those characteristics which influenced the design most. It was concluded that the use of a generalized data base in support of crop assessment is a sound concept. The IDMS11 minicomputer base system is recommended for this purpose.

  17. Physiological Based Simulator Fidelity Design Guidance

    NASA Technical Reports Server (NTRS)

    Schnell, Thomas; Hamel, Nancy; Postnikov, Alex; Hoke, Jaclyn; McLean, Angus L. M. Thom, III

    2012-01-01

    The evolution of the role of flight simulation has reinforced assumptions in aviation that the degree of realism in a simulation system directly correlates to the training benefit, i.e., more fidelity is always better. The construct of fidelity has several dimensions, including physical fidelity, functional fidelity, and cognitive fidelity. Interaction of different fidelity dimensions has an impact on trainee immersion, presence, and transfer of training. This paper discusses research results of a recent study that investigated if physiological-based methods could be used to determine the required level of simulator fidelity. Pilots performed a relatively complex flight task consisting of mission task elements of various levels of difficulty in a fixed base flight simulator and a real fighter jet trainer aircraft. Flight runs were performed using one forward visual channel of 40 deg. field of view for the lowest level of fidelity, 120 deg. field of view for the middle level of fidelity, and unrestricted field of view and full dynamic acceleration in the real airplane. Neuro-cognitive and physiological measures were collected under these conditions using the Cognitive Avionics Tool Set (CATS) and nonlinear closed form models for workload prediction were generated based on these data for the various mission task elements. One finding of the work described herein is that simple heart rate is a relatively good predictor of cognitive workload, even for short tasks with dynamic changes in cognitive loading. Additionally, we found that models that used a wide range of physiological and neuro-cognitive measures can further boost the accuracy of the workload prediction.

  18. XML-based product information processing method for product design

    NASA Astrophysics Data System (ADS)

    Zhang, Zhen Yu

    2012-01-01

    Design knowledge of modern mechatronics product is based on information processing as the center of the knowledge-intensive engineering, thus product design innovation is essentially the knowledge and information processing innovation. Analysis of the role of mechatronics product design knowledge and information management features, a unified model of XML-based product information processing method is proposed. Information processing model of product design includes functional knowledge, structural knowledge and their relationships. For the expression of product function element, product structure element, product mapping relationship between function and structure based on the XML model are proposed. The information processing of a parallel friction roller is given as an example, which demonstrates that this method is obviously helpful for knowledge-based design system and product innovation.

  19. XML-based product information processing method for product design

    NASA Astrophysics Data System (ADS)

    Zhang, Zhen Yu

    2011-12-01

    Design knowledge of modern mechatronics product is based on information processing as the center of the knowledge-intensive engineering, thus product design innovation is essentially the knowledge and information processing innovation. Analysis of the role of mechatronics product design knowledge and information management features, a unified model of XML-based product information processing method is proposed. Information processing model of product design includes functional knowledge, structural knowledge and their relationships. For the expression of product function element, product structure element, product mapping relationship between function and structure based on the XML model are proposed. The information processing of a parallel friction roller is given as an example, which demonstrates that this method is obviously helpful for knowledge-based design system and product innovation.

  20. Designing a successful HMD-based experience

    NASA Technical Reports Server (NTRS)

    Pierce, J. S.; Pausch, R.; Sturgill, C. B.; Christiansen, K. D.; Kaiser, M. K. (Principal Investigator)

    1999-01-01

    For entertainment applications, a successful virtual experience based on a head-mounted display (HMD) needs to overcome some or all of the following problems: entering a virtual world is a jarring experience, people do not naturally turn their heads or talk to each other while wearing an HMD, putting on the equipment is hard, and people do not realize when the experience is over. In the Electric Garden at SIGGRAPH 97, we presented the Mad Hatter's Tea Party, a shared virtual environment experienced by more than 1,500 SIGGRAPH attendees. We addressed these HMD-related problems with a combination of back story, see-through HMDs, virtual characters, continuity of real and virtual objects, and the layout of the physical and virtual environments.

  1. Designing a successful HMD-based experience

    NASA Technical Reports Server (NTRS)

    Pierce, J. S.; Pausch, R.; Sturgill, C. B.; Christiansen, K. D.; Kaiser, M. K. (Principal Investigator)

    1999-01-01

    For entertainment applications, a successful virtual experience based on a head-mounted display (HMD) needs to overcome some or all of the following problems: entering a virtual world is a jarring experience, people do not naturally turn their heads or talk to each other while wearing an HMD, putting on the equipment is hard, and people do not realize when the experience is over. In the Electric Garden at SIGGRAPH 97, we presented the Mad Hatter's Tea Party, a shared virtual environment experienced by more than 1,500 SIGGRAPH attendees. We addressed these HMD-related problems with a combination of back story, see-through HMDs, virtual characters, continuity of real and virtual objects, and the layout of the physical and virtual environments.

  2. Design considerations regarding ellipsoidal mirror based reflectometers.

    PubMed

    Benson, Michael R; Marciniak, Michael A

    2013-11-18

    Hemi-ellipsoidal mirrors are used in reflection-based measurements due to their ability to collect light scattered from one focal point at the other. In this paper, a radiometric model of this energy transfer is derived for arbitrary mirror and detector geometries. This model is used to examine the imaging characteristics of the mirror away from focus for both diffuse and specular light. The radiometric model is applied to several detector geometries for measuring the Directional Hemispherical Reflectance for both diffuse and specular samples. The angular absorption characteristics of the detector are then applied to the measurement to address measurement accuracy for diffuse and specular samples. Examining different detector configurations shows the effectiveness of flat detectors at angles ranging from normal to 50°, and that multifaceted detectors can function from normal incidence to grazing angles.

  3. Organization method for urban planning design data based on GIS

    NASA Astrophysics Data System (ADS)

    Gao, Huijun; Guo, Dazhi; Zhang, Hao; Tian, Ran

    2006-10-01

    GIS and CAD are two different areas of computer technology and its applications, each is widely used in city planning, design and administration. Taking the data management of city planning in Ningbo, Zhejiang province as an example, and has loaded the basic data into database within an urban planning management information system, this paper puts forward a GIS-based organization solution and format standard of planning & design data, which follows designer's usual practice and requirements for design data prescribed by urban planning administration. It works perfectly in Ningbo Urban Planning and Design management system.

  4. Enhanced learning through design problems - teaching a components-based course through design

    NASA Astrophysics Data System (ADS)

    Jensen, Bogi Bech; Högberg, Stig; Fløtum Jensen, Frida av; Mijatovic, Nenad

    2012-08-01

    This paper describes a teaching method used in an electrical machines course, where the students learn about electrical machines by designing them. The aim of the course is not to teach design, albeit this is a side product, but rather to teach the fundamentals and the function of electrical machines through design. The teaching method is evaluated by a student questionnaire, designed to measure the quality and effectiveness of the teaching method. The results of the questionnaire conclusively show that this method labelled 'learning through design' is a very effective way of teaching a components-based course. This teaching method can easily be generalised and used in other courses.

  5. Case-based reasoning support for engineering design

    NASA Astrophysics Data System (ADS)

    Lees, Brian; Hamza, Meer; Irgens, Chris

    2000-10-01

    The potential application of case-based reasoning (CBR) in design support is illustrated through examples drawn from research at the University of Paisley, demonstrating the suitability of CBR for different aspects of design, different problem areas, and different design goals. A quality advisory system has been developed for the early stages of mechanical engineering design, the aim of which is to provide quality advice in a variant design situation. In the domain of software engineering CBR has been applied to advise on which metrics are appropriate fora assessing the quality of the software currently under design. The system integrates CBR with concepts from quality function deployment (QFD) and incorporates a case library holding past software quality histories. CBR has been applied in support of conceptual design: to capture detailed design histories by monitoring designer actions, and thereby support design reuse through the evaluation of designs, through the provision of query, browsing and replay facilities. The resulting system is aimed to support the design of safety critical systems, by assisting in the construction of safety arguments, and cooperative design.

  6. Learning through Interaction: Improving Practice with Design-Based Research

    ERIC Educational Resources Information Center

    Voigt, Christian; Swatman, Paula M. C.

    2006-01-01

    This article presents the first stage of a design-based research project to introduce case-based learning using existing interactive technologies in a major Australian university. The paper initially outlines the relationship between case-based learning, student interaction and the study of interactions--and includes a review of research into…

  7. Learning through Interaction: Improving Practice with Design-Based Research

    ERIC Educational Resources Information Center

    Voigt, Christian; Swatman, Paula M. C.

    2006-01-01

    This article presents the first stage of a design-based research project to introduce case-based learning using existing interactive technologies in a major Australian university. The paper initially outlines the relationship between case-based learning, student interaction and the study of interactions--and includes a review of research into…

  8. Conceptual design of distillation-based hybrid separation processes.

    PubMed

    Skiborowski, Mirko; Harwardt, Andreas; Marquardt, Wolfgang

    2013-01-01

    Hybrid separation processes combine different separation principles and constitute a promising design option for the separation of complex mixtures. Particularly, the integration of distillation with other unit operations can significantly improve the separation of close-boiling or azeotropic mixtures. Although the design of single-unit operations is well understood and supported by computational methods, the optimal design of flowsheets of hybrid separation processes is still a challenging task. The large number of operational and design degrees of freedom requires a systematic and optimization-based design approach. To this end, a structured approach, the so-called process synthesis framework, is proposed. This article reviews available computational methods for the conceptual design of distillation-based hybrid processes for the separation of liquid mixtures. Open problems are identified that must be addressed to finally establish a structured process synthesis framework for such processes.

  9. Studies of Cost Effective Structures Design for Future Space Systems - Summary

    DTIC Science & Technology

    1968-06-01

    IMPLICATIONS Figure 4.0-1: THE SYSTEMS COST APPROACH TO STRUCTURAL RESEARCH 4-3 __ %0_ LU - 0 LUj CLz Lo - o 0- !__ o_ z u-I Li - < -z - _ LU LU -0-1 0~ U- uU CL...and Space Administration, Office of Advanced Research and Technology. Work was accomplished under Contract NAS7-525, which was released under the NASA...OART Space Vehicle Structures Program, and is based on Boeing-sponsored research in cost effective design. The study was performed by The Boeing

  10. Designing for Differences: Cultural Issues in the Design of WWW-based Course-support Sites.

    ERIC Educational Resources Information Center

    Collis, Betty

    1999-01-01

    Examines factors affecting the cultural appropriateness of Web-based course-support sites. Identifies a strategy for accommodating different values of these factors in Web-based course-support systems, based on a set of 10 design guidelines. Describes and evaluates the TeleTOP Method from the University of Twente (The Netherlands) to illustrate…

  11. Design of crusher liner based on time - varying uncertainty theory

    NASA Astrophysics Data System (ADS)

    Tang, J. C.; Shi, B. Q.; Yu, H. J.; Wang, R. J.; Zhang, W. Y.

    2017-09-01

    This article puts forward the time-dependent design method considering the load fluctuation factors for the liner based on the time-varying uncertainty theory. In this method, the time-varying uncertainty design model of liner is constructed by introducing the parameters that affect the wear rate, the volatility and the drift rate. Based on the design example, the timevarying design outline of the moving cone liner is obtained. Based on the theory of minimum wear, the gap curve of wear resistant cavity is designed, and the optimized cavity is obtained by the combination of the thickness of the cone and the cavity gap. Taking the PYGB1821 multi cylinder hydraulic cone crusher as an example, it is proved that the service life of the new liner is improved by more than 14.3%.

  12. Mitigation of Engine Inlet Distortion Through Adjoint-Based Design

    NASA Technical Reports Server (NTRS)

    Ordaz, Irian; Rallabhandi, Sriram; Nielsen, Eric J.; Diskin, Boris

    2017-01-01

    The adjoint-based design capability in FUN3D is extended to allow efficient gradient- based optimization and design of concepts with highly integrated aero-propulsive systems. A circumferential distortion calculation, along with the derivatives needed to perform adjoint-based design, have been implemented in FUN3D. This newly implemented distortion calculation can be used not only for design but also to drive the existing mesh adaptation process and reduce the error associated with the fan distortion calculation. The design capability is demonstrated by the shape optimization of an in-house aircraft concept equipped with an aft fuselage propulsor. The optimization objective is the minimization of flow distortion at the aerodynamic interface plane of this aft fuselage propulsor.

  13. Experience-based design, co-design and experience-based co-design in palliative and end-of-life care.

    PubMed

    Borgstrom, Erica; Barclay, Stephen

    2017-02-16

    Experience-based design, co-design, and experience-based co-design can be used within healthcare to design services that improve the patient, carer and staff experience of the services. As palliative and end-of-life care centrally value person-centred care, we believe that service designers, commissioners and those tasked with making quality improvements will be interested in this growing field. This paper outlines these approaches-with a particular emphasis on experience-based co-design-and describes how they are and can be used within palliative and end-of-life care. Based on a rapid review and several case studies, this article highlights the key lessons learnt from previous projects using these approaches and discusses areas for improvement in current reporting of service design projects.

  14. A supportive architecture for CFD-based design optimisation

    NASA Astrophysics Data System (ADS)

    Li, Ni; Su, Zeya; Bi, Zhuming; Tian, Chao; Ren, Zhiming; Gong, Guanghong

    2014-03-01

    Multi-disciplinary design optimisation (MDO) is one of critical methodologies to the implementation of enterprise systems (ES). MDO requiring the analysis of fluid dynamics raises a special challenge due to its extremely intensive computation. The rapid development of computational fluid dynamic (CFD) technique has caused a rise of its applications in various fields. Especially for the exterior designs of vehicles, CFD has become one of the three main design tools comparable to analytical approaches and wind tunnel experiments. CFD-based design optimisation is an effective way to achieve the desired performance under the given constraints. However, due to the complexity of CFD, integrating with CFD analysis in an intelligent optimisation algorithm is not straightforward. It is a challenge to solve a CFD-based design problem, which is usually with high dimensions, and multiple objectives and constraints. It is desirable to have an integrated architecture for CFD-based design optimisation. However, our review on existing works has found that very few researchers have studied on the assistive tools to facilitate CFD-based design optimisation. In the paper, a multi-layer architecture and a general procedure are proposed to integrate different CFD toolsets with intelligent optimisation algorithms, parallel computing technique and other techniques for efficient computation. In the proposed architecture, the integration is performed either at the code level or data level to fully utilise the capabilities of different assistive tools. Two intelligent algorithms are developed and embedded with parallel computing. These algorithms, together with the supportive architecture, lay a solid foundation for various applications of CFD-based design optimisation. To illustrate the effectiveness of the proposed architecture and algorithms, the case studies on aerodynamic shape design of a hypersonic cruising vehicle are provided, and the result has shown that the proposed architecture

  15. Do Alternative Base Periods Increase Unemployment Insurance Receipt among Low-Educated Unemployed Workers? National Poverty Center Working Paper Series #12-19

    ERIC Educational Resources Information Center

    Gould-Werth, Alix; Shaefer, H. Luke

    2012-01-01

    Unemployment Insurance (UI) is the major social insurance program that protects against lost earnings resulting from involuntary unemployment. Existing literature finds that low-earning unemployed workers experience difficulty accessing UI benefits. The most prominent policy reform designed to increase rates of monetary eligibility, and thus UI…

  16. A Rapid Aerodynamic Design Procedure Based on Artificial Neural Networks

    NASA Technical Reports Server (NTRS)

    Rai, Man Mohan

    2001-01-01

    An aerodynamic design procedure that uses neural networks to model the functional behavior of the objective function in design space has been developed. This method incorporates several improvements to an earlier method that employed a strategy called parameter-based partitioning of the design space in order to reduce the computational costs associated with design optimization. As with the earlier method, the current method uses a sequence of response surfaces to traverse the design space in search of the optimal solution. The new method yields significant reductions in computational costs by using composite response surfaces with better generalization capabilities and by exploiting synergies between the optimization method and the simulation codes used to generate the training data. These reductions in design optimization costs are demonstrated for a turbine airfoil design study where a generic shape is evolved into an optimal airfoil.

  17. Using diagnostic experiences in experience-based innovative design

    NASA Astrophysics Data System (ADS)

    Prabhakar, Sattiraju; Goel, Ashok K.

    1992-03-01

    Designing a novel class of devices requires innovation. Often, the design knowledge of these devices does not identify and address the constraints that are required for their performance in the real world operating environment. So any new design adapted from these devices tend to be similarly sketchy. In order to address this problem, we propose a case-based reasoning method called performance driven innovation (PDI). We model the design as a dynamic process, arrive at a design by adaptation from the known designs, generate failures for this design for some new constraints, and then use this failure knowledge to generate the required design knowledge for the new constraints. In this paper, we discuss two aspects of PDI: the representation of PDI cases and the translation of the failure knowledge into design knowledge for a constraint. Each case in PDI has two components: design and failure knowledge. Both of them are represented using a substance-behavior-function model. Failure knowledge has internal device failure behaviors and external environmental behaviors. The environmental behavior, for a constraint, interacting with the design behaviors, results in the failure internal behavior. The failure adaptation strategy generates functions, from the failure knowledge, which can be addressed using the routine design methods. These ideas are illustrated using a coffee-maker example.

  18. Preparing Instructional Designers for Game-Based Learning: Part 1

    ERIC Educational Resources Information Center

    Hirumi, Atsusi; Appelman, Bob; Rieber, Lloyd; Van Eck, Richard

    2010-01-01

    Like many rapidly growing industries, advances in video game technology are far outpacing research on its design and effectiveness. Relatively little is understood about how to apply what we know about teaching and learning to optimize game-based learning. For the most part, instructional designers know little about game development and video game…

  19. Design-Based Research for Professional Learning for "Cultural Mathematics"

    ERIC Educational Resources Information Center

    Kravia, Geori; Owens, Kay

    2014-01-01

    Design-based research is being used to develop and refine the principles used in professional learning workshops with teachers from three different Papua New Guinean ecologies: highlands, coastal, and inland in a coastal province. The appropriateness of the design of principles for Papua New Guinean Elementary Schools is tried over several phases…

  20. Modeling Web-Based Educational Systems: Process Design Teaching Model

    ERIC Educational Resources Information Center

    Rokou, Franca Pantano; Rokou, Elena; Rokos, Yannis

    2004-01-01

    Using modeling languages is essential to the construction of educational systems based on software engineering principles and methods. Furthermore, the instructional design is undoubtedly the cornerstone of the design and development of educational systems. Although several methodologies and languages have been proposed for the specification of…

  1. Designing, Developing and Implementing WWW-Based Distance Learning.

    ERIC Educational Resources Information Center

    Riley, Peter C.

    The rapid advancement of communication technologies is resulting in a wide array of design and development choices for distance learning projects. The 58th Special Operations Wing at Kirtland Air Force Base, New Mexico, is developing a prototype distance learning project designed to serve geographically separated learner populations. Project staff…

  2. Teaching Database Design with Constraint-Based Tutors

    ERIC Educational Resources Information Center

    Mitrovic, Antonija; Suraweera, Pramuditha

    2016-01-01

    Design tasks are difficult to teach, due to large, unstructured solution spaces, underspecified problems, non-existent problem solving algorithms and stopping criteria. In this paper, we comment on our approach to develop KERMIT, a constraint-based tutor that taught database design. In later work, we re-implemented KERMIT as EER-Tutor, and…

  3. Preparing Instructional Designers for Game-Based Learning: Part 1

    ERIC Educational Resources Information Center

    Hirumi, Atsusi; Appelman, Bob; Rieber, Lloyd; Van Eck, Richard

    2010-01-01

    Like many rapidly growing industries, advances in video game technology are far outpacing research on its design and effectiveness. Relatively little is understood about how to apply what we know about teaching and learning to optimize game-based learning. For the most part, instructional designers know little about game development and video game…

  4. Group-Based Life Design Counseling in an Italian Context

    ERIC Educational Resources Information Center

    Di Fabio, Annamaria; Maree, Jacobus Gideon

    2012-01-01

    This study examined the effectiveness of group-based Life Design Counseling using the Career-Story Interview. Written exercises were used to implement the seven topics in the Career-Story Interview. The present study employed an experimental design that involved two groups of Italian entrepreneurs from the agricultural and trade sectors, namely an…

  5. Optimal Test Design with Rule-Based Item Generation

    ERIC Educational Resources Information Center

    Geerlings, Hanneke; van der Linden, Wim J.; Glas, Cees A. W.

    2013-01-01

    Optimal test-design methods are applied to rule-based item generation. Three different cases of automated test design are presented: (a) test assembly from a pool of pregenerated, calibrated items; (b) test generation on the fly from a pool of calibrated item families; and (c) test generation on the fly directly from calibrated features defining…

  6. Design and Construction Documents Associated with N232, Sustainability Base

    NASA Technical Reports Server (NTRS)

    Zornetzer, Steven F.; Schuler, Raymond F.; Grymes, Rosalind A.

    2014-01-01

    This request comprehensively covers documents associated with the design and construction of Sustainability Base, N232. The intent of this project specifically envisioned broad dissemination of these materials to others undertaking the design and construction of high-performing energy- and resource-efficient buildings in comparable climate zones.

  7. Optimal fractional order PID design via Tabu Search based algorithm.

    PubMed

    Ateş, Abdullah; Yeroglu, Celaleddin

    2016-01-01

    This paper presents an optimization method based on the Tabu Search Algorithm (TSA) to design a Fractional-Order Proportional-Integral-Derivative (FOPID) controller. All parameter computations of the FOPID employ random initial conditions, using the proposed optimization method. Illustrative examples demonstrate the performance of the proposed FOPID controller design method.

  8. Ceramic design concepts based on stress distribution analysis.

    PubMed

    Esquivel-Upshaw, J F; Anusavice, K J

    2000-08-01

    This article discusses general design concepts involved in fabricating ceramic and metal-ceramic restorations based on scientific stress distribution data. These include the effects of ceramic layer thickness, modulus of elasticity of supporting substrates, direction of applied loads, intraoral stress, and crown geometry on the susceptibility of certain restoration designs to fracture.

  9. A Multilevel Analysis of Problem-Based Learning Design Characteristics

    ERIC Educational Resources Information Center

    Scott, Kimberly S.

    2014-01-01

    The increasing use of experience-centered approaches like problem-based learning (PBL) by learning and development practitioners and management educators has raised interest in how to design, implement and evaluate PBL in that field. Of particular interest is how to evaluate the relative impact of design characteristics that exist at the…

  10. A New Design Approach to Game-Based Learning

    ERIC Educational Resources Information Center

    Larsen, Lasse Juel

    2012-01-01

    This paper puts forward a new design perspective for game-based learning. The general idea is to abandon the long sought-after dream of designing a closed learning system, where students in both primary and secondary school could learn--without the interference of teachers--whatever subject they wanted while sitting in front of a computer. This…

  11. Optimal Test Design with Rule-Based Item Generation

    ERIC Educational Resources Information Center

    Geerlings, Hanneke; van der Linden, Wim J.; Glas, Cees A. W.

    2013-01-01

    Optimal test-design methods are applied to rule-based item generation. Three different cases of automated test design are presented: (a) test assembly from a pool of pregenerated, calibrated items; (b) test generation on the fly from a pool of calibrated item families; and (c) test generation on the fly directly from calibrated features defining…

  12. Challenges for Design of Computer-Based Learning Environments.

    ERIC Educational Resources Information Center

    Hakkinen, Paivi

    2002-01-01

    Presents a review of the basic foundations and recent challenges of the main instructional design traditions. Topics include learner characteristics; learner-controlled instruction; learning environments; the role of instructional interventions; computer-based instruction and other new technologies; and new theories of learning and design.…

  13. A Multilevel Analysis of Problem-Based Learning Design Characteristics

    ERIC Educational Resources Information Center

    Scott, Kimberly S.

    2014-01-01

    The increasing use of experience-centered approaches like problem-based learning (PBL) by learning and development practitioners and management educators has raised interest in how to design, implement and evaluate PBL in that field. Of particular interest is how to evaluate the relative impact of design characteristics that exist at the…

  14. Teaching Database Design with Constraint-Based Tutors

    ERIC Educational Resources Information Center

    Mitrovic, Antonija; Suraweera, Pramuditha

    2016-01-01

    Design tasks are difficult to teach, due to large, unstructured solution spaces, underspecified problems, non-existent problem solving algorithms and stopping criteria. In this paper, we comment on our approach to develop KERMIT, a constraint-based tutor that taught database design. In later work, we re-implemented KERMIT as EER-Tutor, and…

  15. Modeling Web-Based Educational Systems: Process Design Teaching Model

    ERIC Educational Resources Information Center

    Rokou, Franca Pantano; Rokou, Elena; Rokos, Yannis

    2004-01-01

    Using modeling languages is essential to the construction of educational systems based on software engineering principles and methods. Furthermore, the instructional design is undoubtedly the cornerstone of the design and development of educational systems. Although several methodologies and languages have been proposed for the specification of…

  16. A Design and Control Environment for Internet-Based Telerobotics

    NASA Technical Reports Server (NTRS)

    Oboe, Roberto; Fiorini, Paolo

    1997-01-01

    This paper describes an environment for the design, simulation and control of Internet-based force-relflecting telerobotc systems. We define these systems as using a segment of the computer network to connect the master to the slave.

  17. Quasi-experimental designs in practice-based research settings: design and implementation considerations.

    PubMed

    Handley, Margaret A; Schillinger, Dean; Shiboski, Stephen

    2011-01-01

    Although randomized controlled trials are often a gold standard for determining intervention effects, in the area of practice-based research (PBR), there are many situations in which individual randomization is not possible. Alternative approaches to evaluating interventions have received increased attention, particularly those that can retain elements of randomization such that they can be considered "controlled" trials. Methodological design elements and practical implementation considerations for two quasi-experimental design approaches that have considerable promise in PBR settings--the stepped-wedge design, and a variant of this design, a wait-list cross-over design, are presented along with a case study from a recent PBR intervention for patients with diabetes. PBR-relevant design features include: creation of a cohort over time that collects control data but allows all participants (clusters or patients) to receive the intervention; staggered introduction of clusters; multiple data collection points; and one-way cross-over into the intervention arm. Practical considerations include: randomization versus stratification, training run in phases; and extended time period for overall study completion. Several design features of practice based research studies can be adapted to local circumstances yet retain elements to improve methodological rigor. Studies that utilize these methods, such as the stepped-wedge design and the wait-list cross-over design, can increase the evidence base for controlled studies conducted within the complex environment of PBR.

  18. The research-design interaction: lessons learned from an evidence-based design studio.

    PubMed

    Haq, Saif; Pati, Debajyoti

    2010-01-01

    As evidence-based design (EBD) emerges as a model of design practice, considerable attention has been given to its research component. However, this overshadows another essential component of EBD-the change agent, namely the designer. EBD introduced a new skill set to the practitioner: the ability to interact with scientific evidence. Industry sources suggest adoption of the EBD approach across a large number of design firms. How comfortable are these designers in integrating research with design decision making? Optimizing the interaction between the primary change agent (the designer) and the evidence is crucial to producing the desired outcomes. Preliminary to examining this question, an architectural design studio was used as a surrogate environment to examine how designers interact with evidence. Twelve students enrolled in a healthcare EBD studio during the spring of 2009. A three-phase didactic structure was adopted: knowing a hospital, knowing the evidence, and designing with knowledge and evidence. Products of the studio and questionnaire responses from the students were used as the data for analysis. The data suggest that optimization of the research-design relationship warrants consideration in four domains: (1) a knowledge structure that is easy to comprehend; (2) phase-complemented representation of evidence; (3) access to context and precedence information; and (4) a designer-friendly vocabulary.

  19. Balancing Expression and Structure in Game Design: Developing Computational Participation Using Studio-Based Design Pedagogy

    ERIC Educational Resources Information Center

    DeVane, Ben; Steward, Cody; Tran, Kelly M.

    2016-01-01

    This article reports on a project that used a game-creation tool to introduce middle-school students ages 10 to 13 to problem-solving strategies similar to those in computer science through the lens of studio-based design arts. Drawing on historic paradigms in design pedagogy and contemporary educational approaches in the digital arts to teach…

  20. Design and Implementation of a Project-Based Active/Cooperative Engineering Design Course for Freshmen

    ERIC Educational Resources Information Center

    Abdulaal, R. M.; Al-Bahi, A. M.; Soliman, A. Y.; Iskanderani, F. I.

    2011-01-01

    A project-based active/cooperative design course is planned, implemented, assessed and evaluated to achieve several desired engineering outcomes. The course allows freshman-level students to gain professional hands-on engineering design experience through an opportunity to practise teamwork, quality principles, communication skills, life-long…

  1. Design and Implementation of a Project-Based Active/Cooperative Engineering Design Course for Freshmen

    ERIC Educational Resources Information Center

    Abdulaal, R. M.; Al-Bahi, A. M.; Soliman, A. Y.; Iskanderani, F. I.

    2011-01-01

    A project-based active/cooperative design course is planned, implemented, assessed and evaluated to achieve several desired engineering outcomes. The course allows freshman-level students to gain professional hands-on engineering design experience through an opportunity to practise teamwork, quality principles, communication skills, life-long…

  2. Balancing Expression and Structure in Game Design: Developing Computational Participation Using Studio-Based Design Pedagogy

    ERIC Educational Resources Information Center

    DeVane, Ben; Steward, Cody; Tran, Kelly M.

    2016-01-01

    This article reports on a project that used a game-creation tool to introduce middle-school students ages 10 to 13 to problem-solving strategies similar to those in computer science through the lens of studio-based design arts. Drawing on historic paradigms in design pedagogy and contemporary educational approaches in the digital arts to teach…

  3. Research by Design: Design-Based Research and the Higher Degree Research student

    ERIC Educational Resources Information Center

    Kennedy-Clark, Shannon

    2013-01-01

    Design-based research lends itself to educational research as the aim of this approach is to develop and refine the design of artefacts, tools and curriculum and to advance existing theory or develop new theories that can support and lead to a deepened understanding of learning. This paper provides an overview of the potential benefits of using a…

  4. Decision making in flood risk based storm sewer network design.

    PubMed

    Sun, S A; Djordjević, S; Khu, S T

    2011-01-01

    It is widely recognised that flood risk needs to be taken into account when designing a storm sewer network. Flood risk is generally a combination of flood consequences and flood probabilities. This paper aims to explore the decision making in flood risk based storm sewer network design. A multiobjective optimization is proposed to find the Pareto front of optimal designs in terms of low construction cost and low flood risk. The decision making process then follows this multi-objective optimization to select a best design from the Pareto front. The traditional way of designing a storm sewer system based on a predefined design storm is used as one of the decision making criteria. Additionally, three commonly used risk based criteria, i.e., the expected flood risk based criterion, the Hurwicz criterion and the stochastic dominance based criterion, are investigated and applied in this paper. Different decisions are made according to different criteria as a result of different concerns represented by the criteria. The proposed procedure is applied to a simple storm sewer network design to demonstrate its effectiveness and the different criteria are compared.

  5. Component-based assistants for MEMS design tools

    NASA Astrophysics Data System (ADS)

    Hahn, Kai; Brueck, Rainer; Schneider, Christian; Schumer, Christian; Popp, Jens

    2001-04-01

    With this paper a new approach for MEMS design tools will be introduced. An analysis of the design tool market leads to the result that most of the designers work with large and inflexible frameworks. Purchasing and maintaining these frameworks is expensive, and gives no optimum support for MEMS design process. The concept of design assistants, carried out with the concept of interacting software components, denotes a new generation of flexible, small, semi-autonomous software systems that are used to solve specific MEMS design tasks in close interaction with the designer. The degree of interaction depends on the complexity of the design task to be performed and the possibility to formalize the respective knowledge. In this context the Internet as one of today's most important communication media provides support for new tool concepts on the basis of the Java programming language. These modern technologies can be used to set up distributed and platform-independent applications. Thus the idea emerged to implement design assistants using Java. According to the MEMS design model new process sequences have to be defined new for every specific design object. As a consequence, assistants have to be built dynamically depending on the requirements of the design process, what can be achieved with component based software development. Componentware offers the possibility to realize design assistants, in areas like design rule checks, process consistency checks, technology definitions, graphical editors, etc. that may reside distributed over the Internet, communicating via Internet protocols. At the University of Siegen a directory for reusable MEMS components has been created, containing a process specification assistant and a layout verification assistant for lithography based MEMS technologies.

  6. CSUMB: Military base conversion as an opportunity for sustainable design

    SciTech Connect

    McDonald, M.; Cooper, P.; Haggard, K.

    1995-11-01

    The conversion of military bases around the country creates an imperative to infuse social, economic, and environmental vitality back into the affected region. Fort Ord in Monterey County, a recent casualty of base closures, is being turned into an opportunity for adaptive reuse as it undergoes the transformation from an army base to a magnet campus of the California State University (CSU) system. The CSU Monterey Bay (CSUMB) campus visionaries included sustainability as a priority in the base conversion. To achieve this goal, the university hired a team of sustainable design consultants. This paper reports on the outcomes of the preliminary design and planning phases.

  7. 77 FR 7604 - Notice Requesting Public Comment on Two Proposed Unemployment Insurance (UI) Program Performance...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-13

    ...). In addition, IPERA establishes requirements for payment recapture audits. Office of Management and... payment recapture audit programs that will drive their annual performance. The targets shall be based on... overpaid to the claimant in the key week (the paid week selected for audit), excluding overpayments...

  8. Optimization of waverider-based hypersonic vehicle designs

    NASA Astrophysics Data System (ADS)

    Takashima, Naruhisa

    1997-09-01

    A hypersonic vehicle model based on osculating cones waverider is developed. The osculating cones waverider is designed to produce uniform flow for a two-dimensional multiple inlet ramp design. A quasi-one-dimensional combustor model with paritial equilibrium combustion is used to calculate the flow through a scramjet engine. The method of osculating cones, the off-design performance calculation of osculating cone waverider, and the vehicle model have been validated with CFD calculations. The vehicle model is used to optimize the vehicle design for Mach 10 cruise mission using the sequential quadradic programming method. The design is optimized maxium L/D, range coefficient, and cruise range for a fixed Mach 10 cruise condition. The L/D of the maximum L/D design is 4.26 which is 9.79% greater than the L/D of the maximum cruise range design; however, the cruise range of the maximum L/D design is 5.70% less than the maximum cruise range design. The design of the maximum cruise range design and the maximum range coefficient design is nearly identical for the present vehicle model. The design is also optimized for maximum range along a qsb{infty} = 1000 psf trajectory from Msb{infty} = 6 to Msb{infty} = 10 to assess the effects of the off-design performance on the Mach 10 designed shape. The difference between the range along the hypersonic trajectory for the optimized design and the cruise range optimized design is only 0.49%. The effects of varying the waverider design Mach number on the optimized Mach 10 cruise range design are studied. The waverider design Mach number is varied from Mach 6 to Mach 12 in increments of Mach 2. The difference in the optimized cruise range performances is less than one percent; however, the anhedral angle decreases by 28% as the design Mach number is increased which makes the Mach 12 design the most favorable in terms of structural considerations.

  9. Computer-based creativity enhanced conceptual design model for non-routine design of mechanical systems

    NASA Astrophysics Data System (ADS)

    Li, Yutong; Wang, Yuxin; Duffy, Alex H. B.

    2014-11-01

    Computer-based conceptual design for routine design has made great strides, yet non-routine design has not been given due attention, and it is still poorly automated. Considering that the function-behavior-structure(FBS) model is widely used for modeling the conceptual design process, a computer-based creativity enhanced conceptual design model(CECD) for non-routine design of mechanical systems is presented. In the model, the leaf functions in the FBS model are decomposed into and represented with fine-grain basic operation actions(BOA), and the corresponding BOA set in the function domain is then constructed. Choosing building blocks from the database, and expressing their multiple functions with BOAs, the BOA set in the structure domain is formed. Through rule-based dynamic partition of the BOA set in the function domain, many variants of regenerated functional schemes are generated. For enhancing the capability to introduce new design variables into the conceptual design process, and dig out more innovative physical structure schemes, the indirect function-structure matching strategy based on reconstructing the combined structure schemes is adopted. By adjusting the tightness of the partition rules and the granularity of the divided BOA subsets, and making full use of the main function and secondary functions of each basic structure in the process of reconstructing of the physical structures, new design variables and variants are introduced into the physical structure scheme reconstructing process, and a great number of simpler physical structure schemes to accomplish the overall function organically are figured out. The creativity enhanced conceptual design model presented has a dominant capability in introducing new deign variables in function domain and digging out simpler physical structures to accomplish the overall function, therefore it can be utilized to solve non-routine conceptual design problem.

  10. Early-Stage Software Design for Usability

    ERIC Educational Resources Information Center

    Golden, Elspeth

    2010-01-01

    In spite of the goodwill and best efforts of software engineers and usability professionals, systems continue to be built and released with glaring usability flaws that are costly and difficult to fix after the system has been built. Although user interface (UI) designers, be they usability or design experts, communicate usability requirements to…

  11. Early-Stage Software Design for Usability

    ERIC Educational Resources Information Center

    Golden, Elspeth

    2010-01-01

    In spite of the goodwill and best efforts of software engineers and usability professionals, systems continue to be built and released with glaring usability flaws that are costly and difficult to fix after the system has been built. Although user interface (UI) designers, be they usability or design experts, communicate usability requirements to…

  12. Parametric Design and Mechanical Analysis of Beams based on SINOVATION

    NASA Astrophysics Data System (ADS)

    Xu, Z. G.; Shen, W. D.; Yang, D. Y.; Liu, W. M.

    2017-07-01

    In engineering practice, engineer needs to carry out complicated calculation when the loads on the beam are complex. The processes of analysis and calculation take a lot of time and the results are unreliable. So VS2005 and ADK are used to develop a software for beams design based on the 3D CAD software SINOVATION with C ++ programming language. The software can realize the mechanical analysis and parameterized design of various types of beams and output the report of design in HTML format. Efficiency and reliability of design of beams are improved.

  13. Reliability based design including future tests and multiagent approaches

    NASA Astrophysics Data System (ADS)

    Villanueva, Diane

    The initial stages of reliability-based design optimization involve the formulation of objective functions and constraints, and building a model to estimate the reliability of the design with quantified uncertainties. However, even experienced hands often overlook important objective functions and constraints that affect the design. In addition, uncertainty reduction measures, such as tests and redesign, are often not considered in reliability calculations during the initial stages. This research considers two areas that concern the design of engineering systems: 1) the trade-off of the effect of a test and post-test redesign on reliability and cost and 2) the search for multiple candidate designs as insurance against unforeseen faults in some designs. In this research, a methodology was developed to estimate the effect of a single future test and post-test redesign on reliability and cost. The methodology uses assumed distributions of computational and experimental errors with re-design rules to simulate alternative future test and redesign outcomes to form a probabilistic estimate of the reliability and cost for a given design. Further, it was explored how modeling a future test and redesign provides a company an opportunity to balance development costs versus performance by simultaneously designing the design and the post-test redesign rules during the initial design stage. The second area of this research considers the use of dynamic local surrogates, or surrogate-based agents, to locate multiple candidate designs. Surrogate-based global optimization algorithms often require search in multiple candidate regions of design space, expending most of the computation needed to define multiple alternate designs. Thus, focusing on solely locating the best design may be wasteful. We extended adaptive sampling surrogate techniques to locate multiple optima by building local surrogates in sub-regions of the design space to identify optima. The efficiency of this method

  14. Statistically Based Approach to Broadband Liner Design and Assessment

    NASA Technical Reports Server (NTRS)

    Nark, Douglas M. (Inventor); Jones, Michael G. (Inventor)

    2016-01-01

    A broadband liner design optimization includes utilizing in-duct attenuation predictions with a statistical fan source model to obtain optimum impedance spectra over a number of flow conditions for one or more liner locations in a bypass duct. The predicted optimum impedance information is then used with acoustic liner modeling tools to design liners having impedance spectra that most closely match the predicted optimum values. Design selection is based on an acceptance criterion that provides the ability to apply increasing weighting to specific frequencies and/or operating conditions. One or more broadband design approaches are utilized to produce a broadband liner that targets a full range of frequencies and operating conditions.

  15. Optimization of Designs for Nanotube-based Scanning Probes

    NASA Technical Reports Server (NTRS)

    Harik, V. M.; Gates, T. S.; Bushnell, Dennis M. (Technical Monitor)

    2002-01-01

    Optimization of designs for nanotube-based scanning probes, which may be used for high-resolution characterization of nanostructured materials, is examined. Continuum models to analyze the nanotube deformations are proposed to help guide selection of the optimum probe. The limitations on the use of these models that must be accounted for before applying to any design problem are presented. These limitations stem from the underlying assumptions and the expected range of nanotube loading, end conditions, and geometry. Once the limitations are accounted for, the key model parameters along with the appropriate classification of nanotube structures may serve as a basis for the design optimization of nanotube-based probe tips.

  16. Conceptional design of the laser ion source based hadrontherapy facility

    NASA Astrophysics Data System (ADS)

    Xie, Xiu-Cui; Song, Ming-Tao; Zhang, Xiao-Hu

    2014-04-01

    A laser ion source (LIS), which can provide a carbon beam with highly stripped state (C6+) and high intensity (several tens mA), would significantly change the overall design of the hadrontherapy facility. The proposed LIS based hadrontherapy facility has the advantages of short linac length, simple injection scheme, and small synchrotron size. With the experience from the DPIS and HITFiL projects that have been conducted in IMP, a conceptional design of the LIS based hadrontherapy facility will be presented, with special attention given to APF type IH DTL design and simulation.

  17. Graph-Based Design Languages: A Lingua Franca for Product Design Including Abstract Geometry.

    PubMed

    Schmidt, Jens; Rudolph, Stephan

    2016-01-01

    Product engineering involves designing and dimensioning a product, including geometric modeling and scientific simulation and analysis to fulfill predetermined requirements. Therefore, the engineering design effort requires a multidisciplinary analysis that is based on a multitude of different models, each of which require a different kind of representation of the same product geometry. The proposed approach uses a design language and a design compiler to translate an abstract source geometry in an abstract representation scheme into an arbitrary target format. With this approach, all models are generated automatically and are consistent with each other.

  18. Model-Based Engineering Design for Trade Space Exploration throughout the Design Cycle

    NASA Technical Reports Server (NTRS)

    Lamassoure, Elisabeth S.; Wall, Stephen D.; Easter, Robert W.

    2004-01-01

    This paper presents ongoing work to standardize model-based system engineering as a complement to point design development in the conceptual design phase of deep space missions. It summarizes two first steps towards practical application of this capability within the framework of concurrent engineering design teams and their customers. The first step is standard generation of system sensitivities models as the output of concurrent engineering design sessions, representing the local trade space around a point design. A review of the chosen model development process, and the results of three case study examples, demonstrate that a simple update to the concurrent engineering design process can easily capture sensitivities to key requirements. It can serve as a valuable tool to analyze design drivers and uncover breakpoints in the design. The second step is development of rough-order- of-magnitude, broad-range-of-validity design models for rapid exploration of the trade space, before selection of a point design. At least one case study demonstrated the feasibility to generate such models in a concurrent engineering session. The experiment indicated that such a capability could yield valid system-level conclusions for a trade space composed of understood elements. Ongoing efforts are assessing the practicality of developing end-to-end system-level design models for use before even convening the first concurrent engineering session, starting with modeling an end-to-end Mars architecture.

  19. Evidence-centered design for simulation-based assessment.

    PubMed

    Mislevy, Robert J

    2013-10-01

    Simulations provide opportunities for people to learn and to develop skills for situations that are expensive, time-consuming, or dangerous. Careful design can support their learning by tailoring the features of situations to their levels of skill, allowing repeated attempts, and providing timely feedback. The same environments provide opportunities for assessing people's capabilities to act in these situations. This article describes an assessment design framework that can help projects develop effective simulation-based assessments. It reviews the rationale and terminology of the "evidence-centered" assessment design framework, discusses how it aligns with the principles of simulation design, and illustrates ideas with examples from engineering and medicine. Advice is offered for designing a new simulation-based assessment and for adapting an existing simulation system for assessment purposes.

  20. Design of Composite Structures Using Knowledge-Based and Case Based Reasoning

    NASA Technical Reports Server (NTRS)

    Lambright, Jonathan Paul

    1996-01-01

    A method of using knowledge based and case based reasoning to assist designers during conceptual design tasks of composite structures was proposed. The cooperative use of heuristics, procedural knowledge, and previous similar design cases suggests a potential reduction in design cycle time and ultimately product lead time. The hypothesis of this work is that the design process of composite structures can be improved by using Case-Based Reasoning (CBR) and Knowledge-Based (KB) reasoning in the early design stages. The technique of using knowledge-based and case-based reasoning facilitates the gathering of disparate information into one location that is easily and readily available. The method suggests that the inclusion of downstream life-cycle issues into the conceptual design phase reduces potential of defective, and sub-optimal composite structures. Three industry experts were interviewed extensively. The experts provided design rules, previous design cases, and test problems. A Knowledge Based Reasoning system was developed using the CLIPS (C Language Interpretive Procedural System) environment and a Case Based Reasoning System was developed using the Design Memory Utility For Sharing Experiences (MUSE) xviii environment. A Design Characteristic State (DCS) was used to document the design specifications, constraints, and problem areas using attribute-value pair relationships. The DCS provided consistent design information between the knowledge base and case base. Results indicated that the use of knowledge based and case based reasoning provided a robust design environment for composite structures. The knowledge base provided design guidance from well defined rules and procedural knowledge. The case base provided suggestions on design and manufacturing techniques based on previous similar designs and warnings of potential problems and pitfalls. The case base complemented the knowledge base and extended the problem solving capability beyond the existence of

  1. Design of Composite Structures Using Knowledge-Based and Case Based Reasoning

    NASA Technical Reports Server (NTRS)

    Lambright, Jonathan Paul

    1996-01-01

    A method of using knowledge based and case based reasoning to assist designers during conceptual design tasks of composite structures was proposed. The cooperative use of heuristics, procedural knowledge, and previous similar design cases suggests a potential reduction in design cycle time and ultimately product lead time. The hypothesis of this work is that the design process of composite structures can be improved by using Case-Based Reasoning (CBR) and Knowledge-Based (KB) reasoning in the early design stages. The technique of using knowledge-based and case-based reasoning facilitates the gathering of disparate information into one location that is easily and readily available. The method suggests that the inclusion of downstream life-cycle issues into the conceptual design phase reduces potential of defective, and sub-optimal composite structures. Three industry experts were interviewed extensively. The experts provided design rules, previous design cases, and test problems. A Knowledge Based Reasoning system was developed using the CLIPS (C Language Interpretive Procedural System) environment and a Case Based Reasoning System was developed using the Design Memory Utility For Sharing Experiences (MUSE) xviii environment. A Design Characteristic State (DCS) was used to document the design specifications, constraints, and problem areas using attribute-value pair relationships. The DCS provided consistent design information between the knowledge base and case base. Results indicated that the use of knowledge based and case based reasoning provided a robust design environment for composite structures. The knowledge base provided design guidance from well defined rules and procedural knowledge. The case base provided suggestions on design and manufacturing techniques based on previous similar designs and warnings of potential problems and pitfalls. The case base complemented the knowledge base and extended the problem solving capability beyond the existence of

  2. Limit states and reliability-based pipeline design. Final report

    SciTech Connect

    Zimmerman, T.J.E.; Chen, Q.; Pandey, M.D.

    1997-06-01

    This report provides the results of a study to develop limit states design (LSD) procedures for pipelines. Limit states design, also known as load and resistance factor design (LRFD), provides a unified approach to dealing with all relevant failure modes combinations of concern. It explicitly accounts for the uncertainties that naturally occur in the determination of the loads which act on a pipeline and in the resistance of the pipe to failure. The load and resistance factors used are based on reliability considerations; however, the designer is not faced with carrying out probabilistic calculations. This work is done during development and periodic updating of the LSD document. This report provides background information concerning limits states and reliability-based design (Section 2), gives the limit states design procedures that were developed (Section 3) and provides results of the reliability analyses that were undertaken in order to partially calibrate the LSD method (Section 4). An appendix contains LSD design examples in order to demonstrate use of the method. Section 3, Limit States Design has been written in the format of a recommended practice. It has been structured so that, in future, it can easily be converted to a limit states design code format. Throughout the report, figures and tables are given at the end of each section, with the exception of Section 3, where to facilitate understanding of the LSD method, they have been included with the text.

  3. On the optimal risk based design of highway drainage structures

    NASA Astrophysics Data System (ADS)

    Tung, Y.-K.; Bao, Y.

    1990-12-01

    For a proposed highway bridge or culvert, the total cost to the public during its expected service life includes capital investment on the structures, regular operation and maintenance costs, and various flood related costs. The flood related damage costs include items such as replacement and repair costs of the highway bridge or culvert, flood plain property damage costs, users costs from traffic interruptions and detours, and others. As the design discharge increases, the required capital investment increases but the corresponding flood related damage costs decrease. Hydraulic design of a bridge or culvert using a riskbased approach is to choose among the alternatives the one associated with the least total expected cost. In this paper, the risk-based design procedure is applied to pipe culvert design. The effect of the hydrologic uncertainties such as sample size and type of flood distribution model on the optimal culvert design parameters including design return period and total expected cost are examined in this paper.

  4. Design Method for EPS Control System Based on KANSEI Structure

    NASA Astrophysics Data System (ADS)

    Saitoh, Yumi; Itoh, Hideaki; Ozaki, Fuminori; Nakamura, Takenobu; Kawaji, Shigeyasu

    Recently, it has been identified that a KANSEI engineering plays an important role in functional design developing for realizing highly sophisticated products. However, in practical development methods, we design products and optimise the design trial and error, which indecates that we depend on the skill set of experts. In this paper, we focus on an automobile electric power steering (EPS) for which a functional design is required. First, the KANSEI structure is determined on the basis of the steering feeling of an experienced driver, and an EPS control design based on this KANSEI structure is proposed. Then, the EPS control parameters are adjusted in accordance with the KANSEI index. Finally, by assessing the experimental results obtained from the driver, the effectiveness of the proposed design method is verified.

  5. Design and implementation of multispectral Image processing system based on VC++

    NASA Astrophysics Data System (ADS)

    Du, Li; Wang, Zhihui; Ge, Xiaoli

    2013-10-01

    Multi-wavelet, extended from single wavelet theory, is able to provide a more accurate image processing analysis method than wavelet. After studying the features of multi-wavelet transform, we realize the core algorithms of an image processing system with GHM multi-wavelet system, by which we can fuse two multi-spectra images by the matching degree-based fusion method. In the phase of image de-noising, we get rid of the noise in the fused image based on the integrated threshold de-noising method. In the stage of image compression, the de-noised image will be compressed and decompressed in adopting the method of Shannon, Fano, Huff-man, and SPIHT (Set Partitioning In Hierarchical Tree) respectively in three different proportional. At last, the results of various stages will be shown in the integrated processing system. This paper uses the MFC mode of VC+ + 6.0 to build a visualization interface (UI) model, to make the interface of our multi-wavelet image processing system concise which occupies less resource and easy to operate. That is, the system consists of three sub-systems, namely: image fusion, image de-noising and image compression. The realization of the sub-system's functions is independent of each other which enhance portability and stability of the whole system.

  6. Designing a Problem-Based Learning Intermediate Composition Course

    ERIC Educational Resources Information Center

    Kumar, Rita; Refaei, Brenda

    2013-01-01

    We used Problem-Based Learning (PBL) as a new pedagogy in an intermediate composition course. Our course design was based in constructivist pedagogical practices, which suggest that knowledge is co-created through social interactions. Although professors have much to offer students, students can also learn important lessons through interactions…

  7. Designing Metacognitive Maps for Web-Based Learning

    ERIC Educational Resources Information Center

    Lee, Miyoung; Baylor, Amy L.

    2006-01-01

    This paper provides guidelines for designing metacognitive maps in web-based learning environments. A metacognitive map is a visual interface-based tool that supports metacognition throughout the entire learning process. Inspired by the four key metacognitive skills of planning, monitoring, evaluating, and revising, the metacognitive map is…

  8. Designing a Programming-Based Approach for Modelling Scientific Phenomena

    ERIC Educational Resources Information Center

    Simpson, Gordon; Hoyles, Celia; Noss, Richard

    2005-01-01

    We describe an iteratively designed sequence of activities involving the modelling of one-dimensional collisions between moving objects based on programming in ToonTalk. Students aged 13-14 years in two settings (London and Cyprus) investigated a number of collision situations, classified into six classes based on the relative velocities and…

  9. Structure-Based Design of Trna-Guanine Transglycosylase Inhibitors

    NASA Astrophysics Data System (ADS)

    Klebe, Gerhard

    Taking the development of inhibitors for the tRNA-modifying enzyme tRNA-guanine transglycosylase (TGT) as an example, the scope of a structure-based drug development project will be demonstrated, performed via several cycles of iterative design. The described example is based on studies, performed at ETH-Zurich and University of Marburg in joint collaboration. As these studies have been executed in an academic environment, different tools of structure-based design have been applied and several issues of more fundamental interest to the methodological background of the project could be addressed.

  10. [Computational chemistry in structure-based drug design].

    PubMed

    Cao, Ran; Li, Wei; Sun, Han-Zi; Zhou, Yu; Huang, Niu

    2013-07-01

    Today, the understanding of the sequence and structure of biologically relevant targets is growing rapidly and researchers from many disciplines, physics and computational science in particular, are making significant contributions to modern biology and drug discovery. However, it remains challenging to rationally design small molecular ligands with desired biological characteristics based on the structural information of the drug targets, which demands more accurate calculation of ligand binding free-energy. With the rapid advances in computer power and extensive efforts in algorithm development, physics-based computational chemistry approaches have played more important roles in structure-based drug design. Here we reviewed the newly developed computational chemistry methods in structure-based drug design as well as the elegant applications, including binding-site druggability assessment, large scale virtual screening of chemical database, and lead compound optimization. Importantly, here we address the current bottlenecks and propose practical solutions.

  11. Front end design of smartphone-based mobile health

    NASA Astrophysics Data System (ADS)

    Zhang, Changfan; He, Lingsong; Gao, Zhiqiang; Ling, Cong; Du, Jianhao

    2015-02-01

    Mobile health has been a new trend all over the world with the rapid development of intelligent terminals and mobile internet. It can help patients monitor health in-house and is convenient for doctors to diagnose remotely. Smart-phone-based mobile health has big advantages in cost and data sharing. Front end design of it mainly focuses on two points: one is implementation of medical sensors aimed at measuring kinds of medical signal; another is acquisition of medical signal from sensors to smart phone. In this paper, the above two aspects were both discussed. First, medical sensor implementation was proposed to refer to mature measurement solutions with ECG (electrocardiograph) sensor design taken for example. And integrated chip using can simplify design. Then second, typical data acquisition architecture of smart phones, namely Bluetooth and MIC (microphone)-based architecture, were compared. Bluetooth architecture should be equipped with an acquisition card; MIC design uses sound card of smart phone instead. Smartphone-based virtual instrument app design corresponding to above acquisition architecture was discussed. In experiments, Bluetooth and MIC architecture were used to acquire blood pressure and ECG data respectively. The results showed that Bluetooth design can guarantee high accuracy during the acquisition and transmission process, and MIC design is competitive because of low cost and convenience.

  12. Sequential ensemble-based optimal design for parameter estimation

    NASA Astrophysics Data System (ADS)

    Man, Jun; Zhang, Jiangjiang; Li, Weixuan; Zeng, Lingzao; Wu, Laosheng

    2016-10-01

    The ensemble Kalman filter (EnKF) has been widely used in parameter estimation for hydrological models. The focus of most previous studies was to develop more efficient analysis (estimation) algorithms. On the other hand, it is intuitively understandable that a well-designed sampling (data-collection) strategy should provide more informative measurements and subsequently improve the parameter estimation. In this work, a Sequential Ensemble-based Optimal Design (SEOD) method, coupled with EnKF, information theory and sequential optimal design, is proposed to improve the performance of parameter estimation. Based on the first-order and second-order statistics, different information metrics including the Shannon entropy difference (SD), degrees of freedom for signal (DFS) and relative entropy (RE) are used to design the optimal sampling strategy, respectively. The effectiveness of the proposed method is illustrated by synthetic one-dimensional and two-dimensional unsaturated flow case studies. It is shown that the designed sampling strategies can provide more accurate parameter estimation and state prediction compared with conventional sampling strategies. Optimal sampling designs based on various information metrics perform similarly in our cases. The effect of ensemble size on the optimal design is also investigated. Overall, larger ensemble size improves the parameter estimation and convergence of optimal sampling strategy. Although the proposed method is applied to unsaturated flow problems in this study, it can be equally applied in any other hydrological problems.

  13. Research on performance-based seismic design criteria

    NASA Astrophysics Data System (ADS)

    Xie, Li-Li; Ma, Yu-Hong

    2002-03-01

    The seismic design criterion adopted in the existing seismic design codes is reviewed. It is pointed out that the presently used seismic design criterion is not satisfied with the requirements of nowadays social and economic development. A new performance-based seismic design criterion that is composed of three components is presented in this paper. It can not only effectively control the economic losses and casualty, but also ensure the building’s function in proper operation during earthquakes. The three components are: classification of seismic design for buildings, determination of seismic design intensity and/or seismic design ground motion for controlling seismic economic losses and casualties, and determination of the importance factors in terms of service periods of buildings. For controlling the seismic human losses, the idea of socially acceptable casualty level is presented and the ‘Optimal Economic Decision Model’ and ‘Optimal Safe Decision Model’ are established. Finally, a new method is recommended for calculating the importance factors of structures by adjusting structures service period on the base of more important structure with longer service period than the conventional ones. Therefore, the more important structure with longer service periods will be designed for higher seismic loads, in case the exceedance probability of seismic hazard in different service period is same.

  14. Advanced Information Technology in Simulation Based Life Cycle Design

    NASA Technical Reports Server (NTRS)

    Renaud, John E.

    2003-01-01

    In this research a Collaborative Optimization (CO) approach for multidisciplinary systems design is used to develop a decision based design framework for non-deterministic optimization. To date CO strategies have been developed for use in application to deterministic systems design problems. In this research the decision based design (DBD) framework proposed by Hazelrigg is modified for use in a collaborative optimization framework. The Hazelrigg framework as originally proposed provides a single level optimization strategy that combines engineering decisions with business decisions in a single level optimization. By transforming this framework for use in collaborative optimization one can decompose the business and engineering decision making processes. In the new multilevel framework of Decision Based Collaborative Optimization (DBCO) the business decisions are made at the system level. These business decisions result in a set of engineering performance targets that disciplinary engineering design teams seek to satisfy as part of subspace optimizations. The Decision Based Collaborative Optimization framework more accurately models the existing relationship between business and engineering in multidisciplinary systems design.

  15. A computer-based building design support environment

    SciTech Connect

    Papamichael, K.; Selkowitz, S.E.

    1991-06-01

    Continuously decreasing cost has brought computers into most architectural and engineering offices, most commonly for activities such as drafting, accounting and word processing. Computers are used less often to predict the performance of design solutions. However, most performance simulation software packages are simplified versions of main-frame analytical tools, originally developed for research. Such software packages focus on specific design issues according to the research needs. Also, the data input requirements are complicated and incompatible with each other, and the output data are usually specialized and difficult to interpret. It is yet to be seen how the increasing memory and processing speed of computers, the two main advantages that computers have over the human brain, can be used to assist designers throughout the design process, allowing them to organize design projects electronically. We describe the design and initial implementation of a computer-based Building Design Support Environment whose structure and operation are derived from a detailed theoretical analysis of the design process, into the iterative and interactive activities that contribute towards the formulation of design criteria, the generation of potential solutions, and their evaluation. The identified design activities are characterized with respect to the nature of knowledge requirements and the degree to which they can be specified and delegated to computers. The results are considered as criteria to determine the level of automation and the interaction between designers and computers, to model the delegateable and non-delegateable activities, respectively. We believe this approach, when fully implemented, has a good chance of providing building designers with a powerful environment to enhance building design.

  16. Developing the Common Data Base for Management Information Systems: VI. Designing a Data Base for Growth.

    ERIC Educational Resources Information Center

    Podell, Harold J.

    A subset of data base management techniques for the hardware/software functions necessary to support a management information system are discussed. Seven basic dimensions of data base design are: (1) data base life span, (2) logical record growth, (3) record content growth, (4) data set organization, (5) linkages, (6) design criteria and (7)…

  17. De facto methodologies toward the synthesis and scale-up production of UiO-66-type metal-organic frameworks and membrane materials.

    PubMed

    Hu, Zhigang; Zhao, Dan

    2015-11-28

    Metal-organic frameworks (MOFs) are architected via coordination bonds between inorganic metal nodes and organic ligands. They have become emerging advanced porous materials and gained ever-increasing attention in the past decade. In particular, overwhelming studies have been devoted to those hydrostable MOFs which are suggested to be highly promising for industrial applications. UiO-66 is such a unique MOF because of its superior thermal/chemical stability and structural tunability. However, its repeatable, green, and scale-up synthesis remains a challenge for its commercialization and implementation in industrial applications. This perspective mainly summarises the recent development in the synthesis of UiO-66-type MOFs and their related composites. From a scale-up viewpoint, we also present some important advances in the batch and continuous reactor synthesis toward their massive production (226 references).

  18. Connecting defects and amorphization in UiO-66 and MIL-140 metal-organic frameworks: a combined experimental and computational study

    NASA Astrophysics Data System (ADS)

    Bennett, Thomas D.; Todorova, Tanya K.; Baxter, Emma F.; Reid, David G.; Gervais, Christel; Bueken, Bart; Van de Voorde, B.; De Vos, Dirk; Keen, David A.; Mellot-Draznieks, Caroline

    The mechanism and products of the structural collapse of the metal-organic frameworks (MOFs) UiO-66, MIL-140B and MIL-140C upon ball-milling are investigated through solid state 13C NMR and pair distribution function (PDF) studies, finding amorphization to proceed by the breaking of a fraction of metal-ligand bonding in each case. The amorphous products contain inorganic-organic bonding motifs reminiscent of the crystalline phases. Whilst the inorganic Zr6O4(OH)4 clusters of UiO-66 remain intact upon structural collapse, the ZrO backbone of the MIL-140 frameworks undergoes substantial distortion. Density functional theory calculations have been performed to investigate defective models of MIL-140B and show, through comparison of calculated and experimental 13C NMR spectra, that amorphization and defects in the materials are linked.

  19. Cutoff Designs for Community-Based Intervention Studies

    PubMed Central

    Pennell, Michael L.; Hade, Erinn M.; Murray, David M.; Rhoda, Dale A.

    2011-01-01

    Summary Public health interventions are often designed to target communities defined either geographically (e.g., cities, counties) or socially (e.g., schools or workplaces). The group randomized trial (GRT) is regarded as the gold standard for evaluating these interventions. However, community leaders may object to randomization as some groups may be denied a potentially beneficial intervention. Under a regression discontinuity design (RDD), individuals may be assigned to treatment based on the levels of a pretest measure, thereby allowing those most in need of the treatment to receive it. In this article, we consider analysis, power, and sample size issues in applying the RDD and related cutoff designs in community-based intervention studies. We examine the power of these designs as a function of intraclass correlation, number of groups, and number of members per group and compare results to the traditional GRT. PMID:21500240

  20. The multiple baseline design for evaluating population-based research.

    PubMed

    Hawkins, Nathan G; Sanson-Fisher, Robert W; Shakeshaft, Anthony; D'Este, Catherine; Green, Lawrence W

    2007-08-01

    There is a need for pragmatic and rigorous research designs to evaluate the effectiveness of population-based health interventions. The randomized controlled trial (RCT) has limitations in its practicality, ethical appropriateness, and cost when evaluating population-based interventions. Like RCTs, the multiple baseline design can demonstrate that a change in behavior has occurred, the change is a result of the intervention, and the change is significant. Especially important practical advantages over the RCT are that this design requires fewer population groups and communities may act as their own controls. Advantages and methodologic limitations of the multiple baseline design are discussed, and where feasible, strategies to minimize the impact of its limitations are suggested. Recommendations for future research are included.

  1. Metal-organic framework UiO-66 coated stainless steel fiber for solid-phase microextraction of phenols in water samples.

    PubMed

    Shang, Hai-Bo; Yang, Cheng-Xiong; Yan, Xiu-Ping

    2014-08-29

    Effective solid-phase microextraction (SPME) of polar phenols from water samples is usually difficult due to the strong interaction between polar phenols and aqueous matrix. Here, we report the fabrication of a metal-organic framework UiO-66 coated stainless steel fiber via physical adhesion for the SPME of polar phenols (phenol, o-cresol, p-cresol, 2,6-dimethylphenol, 2,4-dichlorophenol and 2,6-dichlorophenol) in water samples before gas chromatographic separation with flame ionic detection. Headspace SPME of 10mL sample solution with the fabricated UiO-66 coated fiber gave the enhancement factors of 160 (phenol) - 3769 (2,4-dichlorophenol), and the linear ranges of 1-1000μgL(-1) (2,6-dimethylphenol, 2,4-dichlorophenol and 2,6-dichlorophenol), 1-500μgL(-1) (o-cresol and p-cresol) and 5-500μgL(-1) (phenol). The detection limits ranged from 0.11μgL(-1) (2,6-dimethylphenol) to 1.23μgL(-1) (phenol). The precision (relative standard deviations, RSDs) for six replicate determinations of the analytes at 100μgL(-1) using a single UiO-66 coated fiber ranged from 2.8% to 6.2%. The fiber-to-fiber reproducibility (RSDs) for three parallel UiO-66 coated fibers varied from 5.9% to 10%. The recoveries obtained by spiking 5μgL(-1) of the phenols in the water samples ranged from 80% to 115%.

  2. Thin Film Nanocomposite Membrane Filled with Metal-Organic Frameworks UiO-66 and MIL-125 Nanoparticles for Water Desalination.

    PubMed

    Kadhom, Mohammed; Hu, Weiming; Deng, Baolin

    2017-06-14

    Knowing that the world is facing a shortage of fresh water, desalination, in its different forms including reverse osmosis, represents a practical approach to produce potable water from a saline source. In this report, two kinds of Metal-Organic Frameworks (MOFs) nanoparticles (NPs), UiO-66 (~100 nm) and MIL-125 (~100 nm), were embedded separately into thin-film composite membranes in different weight ratios, 0%, 0.05%, 0.1%, 0.15%, 0.2%, and 0.3%. The membranes were synthesized by the interfacial polymerization (IP) of m-phenylenediamine (MPD) in aqueous solution and trimesoyl chloride (TMC) in an organic phase. The as-prepared membranes were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), contact angle measurement, attenuated total reflection Fourier transform infrared (ATR FT-IR) spectroscopy, and salt rejection and water flux assessments. Results showed that both UiO-66 and MIL-125 could improve the membranes' performance and the impacts depended on the NPs loading. At the optimum NPs loadings, 0.15% for UiO-66 and 0.3% for MIL-125, the water flux increased from 62.5 L/m² h to 74.9 and 85.0 L/m² h, respectively. NaCl rejection was not significantly affected (UiO-66) or slightly improved (MIL-125) by embedding these NPs, always at >98.5% as tested at 2000 ppm salt concentration and 300 psi transmembrane pressure. The results from this study demonstrate that it is promising to apply MOFs NPs to enhance the TFC membrane performance for desalination.

  3. Thin Film Nanocomposite Membrane Filled with Metal-Organic Frameworks UiO-66 and MIL-125 Nanoparticles for Water Desalination

    PubMed Central

    Kadhom, Mohammed; Hu, Weiming; Deng, Baolin

    2017-01-01

    Knowing that the world is facing a shortage of fresh water, desalination, in its different forms including reverse osmosis, represents a practical approach to produce potable water from a saline source. In this report, two kinds of Metal-Organic Frameworks (MOFs) nanoparticles (NPs), UiO-66 (~100 nm) and MIL-125 (~100 nm), were embedded separately into thin-film composite membranes in different weight ratios, 0%, 0.05%, 0.1%, 0.15%, 0.2%, and 0.3%. The membranes were synthesized by the interfacial polymerization (IP) of m-phenylenediamine (MPD) in aqueous solution and trimesoyl chloride (TMC) in an organic phase. The as-prepared membranes were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), contact angle measurement, attenuated total reflection Fourier transform infrared (ATR FT-IR) spectroscopy, and salt rejection and water flux assessments. Results showed that both UiO-66 and MIL-125 could improve the membranes’ performance and the impacts depended on the NPs loading. At the optimum NPs loadings, 0.15% for UiO-66 and 0.3% for MIL-125, the water flux increased from 62.5 L/m2 h to 74.9 and 85.0 L/m2 h, respectively. NaCl rejection was not significantly affected (UiO-66) or slightly improved (MIL-125) by embedding these NPs, always at >98.5% as tested at 2000 ppm salt concentration and 300 psi transmembrane pressure. The results from this study demonstrate that it is promising to apply MOFs NPs to enhance the TFC membrane performance for desalination. PMID:28613247

  4. Separation of Lanthanide Ions with Kläui Ligand Resin

    SciTech Connect

    Granger, Trinity D.; Henry, Victoria A.; Latesky, Stanley

    2007-07-01

    Separation and pre-concentration of the desired analyte is often a critical step in many radioanalytical methods. Current procedures for separating and concentrating analytes for detection are complex, and can be both expensive and time consuming. Therefore, the purpose of this research is to develop an alternative method of separating lanthanide ions through the use of an extraction chromatography resin containing a Klaui ligand salt. This research is a continuation of a concerted effort to develop new methods of detecting small concentrations of radionuclides and lanthanides using Klaui ligands. The Klaui ligands, C5Me5Co(OP(OR)2)3- (R=Me, Et, n-Pr) (LOR-), have unique affinity for lanthanide and actinide ions in the presence of competing metal ions. The use of 1 wt% NaLOR (R=Et or n-Pr) adsorbed onto resin support has been shown to extract lanthanide ions from aqueous nitric acid solutions of different concentrations. In order to further evaluate the utility of these materials in radiochemical separation, the selectivity of the resins for the different lanthanide ions was examined by measuring the distribution coefficients (Kd) for a series of lanthanides over a range of solution conditions. Based on prior research with actinide ions, it was hypothesized that the lanthanide ions would bond strongly with the Klaui ligands. The success of this research is important, because it will assist in expanding and improving current automated radiochemical methods, which will decrease the cost of developing and implementing radiochemical methods. To date, Kd values have been determined for Eu+3, Nd+3 and Pr+3 under varying nitric acid (HNO3) concentration, using a resin consisting of 1.0 wt% NaLOPr on Amberlite XAD-7HP. The dependence of the Kd values for Eu+3 has also been examined as a function of the ligand-to-europium ratio and the nitrate concentration. Decreasing Kd values were obtained upon increasing the nitric acid concentration, indicating protonation of the

  5. A Design-Based Research Investigation of a Web-Based Learning Environment Designed to Support the Reading Process

    ERIC Educational Resources Information Center

    Kidwai, Khusro

    2009-01-01

    This research study had two purposes, (a) to design and develop a Web-based learning environment that supports the use of a set of reading strategies, and (b) to investigate the impact of this Web-based learning environment on readers' "memory" and "understanding" of an instructional unit on the human heart (Dwyer &…

  6. A Design-Based Research Investigation of a Web-Based Learning Environment Designed to Support the Reading Process

    ERIC Educational Resources Information Center

    Kidwai, Khusro

    2009-01-01

    This research study had two purposes, (a) to design and develop a Web-based learning environment that supports the use of a set of reading strategies, and (b) to investigate the impact of this Web-based learning environment on readers' "memory" and "understanding" of an instructional unit on the human heart (Dwyer &…

  7. Novel parameter-based flexure bearing design method

    NASA Astrophysics Data System (ADS)

    Amoedo, Simon; Thebaud, Edouard; Gschwendtner, Michael; White, David

    2016-06-01

    A parameter study was carried out on the design variables of a flexure bearing to be used in a Stirling engine with a fixed axial displacement and a fixed outer diameter. A design method was developed in order to assist identification of the optimum bearing configuration. This was achieved through a parameter study of the bearing carried out with ANSYS®. The parameters varied were the number and the width of the arms, the thickness of the bearing, the eccentricity, the size of the starting and ending holes, and the turn angle of the spiral. Comparison was made between the different designs in terms of axial and radial stiffness, the natural frequency, and the maximum induced stresses. Moreover, the Finite Element Analysis (FEA) was compared to theoretical results for a given design. The results led to a graphical design method which assists the selection of flexure bearing geometrical parameters based on pre-determined geometric and material constraints.

  8. Design of integration-ready metasurface-based infrared absorbers

    SciTech Connect

    Ogando, Karim Pastoriza, Hernán

    2015-07-28

    We introduce an integration ready design of metamaterial infrared absorber, highly compatible with many kinds of fabrication processes. We present the results of an exhaustive experimental characterization, including an analysis of the effects of single meta-atom geometrical parameters and collective arrangement. We confront the results with the theoretical interpretations proposed in the literature. Based on the results, we develop a set of practical design rules for metamaterial absorbers in the infrared region.

  9. Design of Power Quality Monitor Based on Embedded Industrial Computer

    NASA Astrophysics Data System (ADS)

    Junfeng, Huang; Hao, Sun; Xiaolin, Wei

    A design about electric power quality monitor device based on embedded industrial computer was proposed. On this basis, we introduced the framework and arithmetic of the device. Because of the existence of the harmonic disturbance, a scheme of adding windows combined with interpolation arithmetic was used to promote the detection accuracy; In the meanwhile, by means of the programming tool of Delphi, a good interface was designed. Through the experiment, we justify the device shows the well reliability and practicability.

  10. The design of a microprocessor-based data logger

    USGS Publications Warehouse

    Leap, K.J.; Dedini, L.A.

    1982-01-01

    The design of a microprocessor-based data logger, which collects and digitizes analog voltage signals from a continuous-measuring instrumentation system and transmits serial data to a magnetic tape recorder, is discussed. The data logger was assembled from commercially-available components and can be user-programmed for greater flexibility. A description of the data logger hardware and software designs, general operating instructions, the microprocessor program listing, and electrical schematic diagrams are presented.

  11. Eco-effective design and evidence-based design: perceived synergy and conflict.

    PubMed

    Shepley, Mardelle McCuskey; Baum, Mara; Ginsberg, Rachel; Rostenberg, Bill

    2009-01-01

    Eco-effective design (EED) and evidence-based design (EBD) are two powerful trends currently shaping healthcare architecture. EED addresses whether/how the design and operation of buildings improve ecological value and enhance human health. EBD addresses whether/how the design and operation of buildings support positive health outcomes in the built environment through a growing collection of solutions informed by research and practical knowledge. The primary hypothesis of this study was that EBD and EED are compatible approaches to health facility design, especially when addressing the impact of the environment on human health. To explore this hypothesis, healthcare facility administrators were surveyed regarding their perceptions of the relationship between EED and EBD. Input from focus groups and EED and EBD experts was used to formulate the administrator questionnaire. The study concluded that the relationship between EED and EBD typically was synergistic. ©2009 VENDOME GROUP, LLC

  12. A knowledge-based design framework for airplane conceptual and preliminary design

    NASA Astrophysics Data System (ADS)

    Anemaat, Wilhelmus A. J.

    The goal of work described herein is to develop the second generation of Advanced Aircraft Analysis (AAA) into an object-oriented structure which can be used in different environments. One such environment is the third generation of AAA with its own user interface, the other environment with the same AAA methods (i.e. the knowledge) is the AAA-AML program. AAA-AML automates the initial airplane design process using current AAA methods in combination with AMRaven methodologies for dependency tracking and knowledge management, using the TechnoSoft Adaptive Modeling Language (AML). This will lead to the following benefits: (1) Reduced design time: computer aided design methods can reduce design and development time and replace tedious hand calculations. (2) Better product through improved design: more alternative designs can be evaluated in the same time span, which can lead to improved quality. (3) Reduced design cost: due to less training and less calculation errors substantial savings in design time and related cost can be obtained. (4) Improved Efficiency: the design engineer can avoid technically correct but irrelevant calculations on incomplete or out of sync information, particularly if the process enables robust geometry earlier. Although numerous advancements in knowledge based design have been developed for detailed design, currently no such integrated knowledge based conceptual and preliminary airplane design system exists. The third generation AAA methods are tested over a ten year period on many different airplane designs. Using AAA methods will demonstrate significant time savings. The AAA-AML system will be exercised and tested using 27 existing airplanes ranging from single engine propeller, business jets, airliners, UAV's to fighters. Data for the varied sizing methods will be compared with AAA results, to validate these methods. One new design, a Light Sport Aircraft (LSA), will be developed as an exercise to use the tool for designing a new airplane

  13. Conceptual design for a lunar-base CELSS

    NASA Technical Reports Server (NTRS)

    Schwartzkopf, Steven H.; Cullingford, Hatice S.

    1990-01-01

    Future human exploration is key to the United States National Space Policy goal of maintaining a world leadership position in space. In the past, spacecraft life support systems have used open-loop technologies that were simple and sufficiently reliable to demonstrate the feasibility of spaceflight. A critical technology area needing development in support of both long duration missions and the establishment of lunar or planetary bases is regenerative life support. The information presented in this paper describes a conceptual design of a Lunar Base Controlled Ecological Life Support System (LCELSS) which supports a crew size ranging from 4 to 100. The system includes, or incorporates interfaces with, eight primary subsystems. An initial description of the Lunar-Base CELSS subsystems is provided within the framework of the conceptual design. The system design includes both plant (algae and higher plant) and animal species as potential food sources.

  14. Computational approaches for fragment-based and de novo design.

    PubMed

    Loving, Kathryn; Alberts, Ian; Sherman, Woody

    2010-01-01

    Fragment-based and de novo design strategies have been used in drug discovery for years. The methodologies for these strategies are typically discussed separately, yet the applications of these techniques overlap substantially. We present a review of various fragment-based discovery and de novo design protocols with an emphasis on successful applications in real-world drug discovery projects. Furthermore, we illustrate the strengths and weaknesses of the various approaches and discuss how one method can be used to complement another. We also discuss how the incorporation of experimental data as constraints in computational models can produce novel compounds that occupy unique areas in intellectual property (IP) space yet are biased toward the desired chemical property space. Finally, we present recent research results suggesting that computational tools applied to fragment-based discovery and de novo design can have a greater impact on the discovery process when coupled with the right experiments.

  15. Fatigue reliability based optimal design of planar compliant micropositioning stages

    NASA Astrophysics Data System (ADS)

    Wang, Qiliang; Zhang, Xianmin

    2015-10-01

    Conventional compliant micropositioning stages are usually developed based on static strength and deterministic methods, which may lead to either unsafe or excessive designs. This paper presents a fatigue reliability analysis and optimal design of a three-degree-of-freedom (3 DOF) flexure-based micropositioning stage. Kinematic, modal, static, and fatigue stress modelling of the stage were conducted using the finite element method. The maximum equivalent fatigue stress in the hinges was derived using sequential quadratic programming. The fatigue strength of the hinges was obtained by considering various influencing factors. On this basis, the fatigue reliability of the hinges was analysed using the stress-strength interference method. Fatigue-reliability-based optimal design of the stage was then conducted using the genetic algorithm and MATLAB. To make fatigue life testing easier, a 1 DOF stage was then optimized and manufactured. Experimental results demonstrate the validity of the approach.

  16. Science-based bioprocess design for filamentous fungi.

    PubMed

    Posch, Andreas E; Herwig, Christoph; Spadiut, Oliver

    2013-01-01

    Industrial bioprocesses are commonly based on empiricism rather than scientific process understanding. In this review, we summarize current strategies for science-based bioprocess design and control for filamentous fungi aiming at reducing development times and increasing process economics. We discuss recent developments and trends regarding three crucial aspects throughout the bioprocess life cycle of filamentous fungi, namely (i) strain and inoculum characterization, (ii) morphology, and (iii) rheology, as well as their effects on process performance. Complex interconnections between strain, inoculum, morphology, rheology, and process design are outlined and discussed. Only combining different hard type sensors with soft sensor technology and the development of simplified mechanistic models can enable science-based bioprocess design for filamentous fungi. Copyright © 2012 Elsevier Ltd. All rights reserved.

  17. Target based drug design - a reality in virtual sphere.

    PubMed

    Verma, Saroj; Prabhakar, Yenamandra S

    2015-01-01

    The target based drug design approaches are a series of computational procedures, including visualization tools, to support the decision systems of drug design/discovery process. In the essence of biological targets shaping the potential lead/drug molecules, this review presents a comprehensive position of different components of target based drug design which include target identification, protein modeling, molecular dynamics simulations, binding/catalytic sites identification, docking, virtual screening, fragment based strategies, substructure treatment of targets in tackling drug resistance, in silico ADMET, structural vaccinology, etc along with the key issues involved therein and some well investigated case studies. The concepts and working of these procedures are critically discussed to arouse interest and to advance the drug research.

  18. Probabilistic performance-based design for high performance control systems

    NASA Astrophysics Data System (ADS)

    Micheli, Laura; Cao, Liang; Gong, Yongqiang; Cancelli, Alessandro; Laflamme, Simon; Alipour, Alice

    2017-04-01

    High performance control systems (HPCS) are advanced damping systems capable of high damping performance over a wide frequency bandwidth, ideal for mitigation of multi-hazards. They include active, semi-active, and hybrid damping systems. However, HPCS are more expensive than typical passive mitigation systems, rely on power and hardware (e.g., sensors, actuators) to operate, and require maintenance. In this paper, a life cycle cost analysis (LCA) approach is proposed to estimate the economic benefit these systems over the entire life of the structure. The novelty resides in the life cycle cost analysis in the performance based design (PBD) tailored to multi-level wind hazards. This yields a probabilistic performance-based design approach for HPCS. Numerical simulations are conducted on a building located in Boston, MA. LCA are conducted for passive control systems and HPCS, and the concept of controller robustness is demonstrated. Results highlight the promise of the proposed performance-based design procedure.

  19. Fatigue reliability based optimal design of planar compliant micropositioning stages.

    PubMed

    Wang, Qiliang; Zhang, Xianmin

    2015-10-01

    Conventional compliant micropositioning stages are usually developed based on static strength and deterministic methods, which may lead to either unsafe or excessive designs. This paper presents a fatigue reliability analysis and optimal design of a three-degree-of-freedom (3 DOF) flexure-based micropositioning stage. Kinematic, modal, static, and fatigue stress modelling of the stage were conducted using the finite element method. The maximum equivalent fatigue stress in the hinges was derived using sequential quadratic programming. The fatigue strength of the hinges was obtained by considering various influencing factors. On this basis, the fatigue reliability of the hinges was analysed using the stress-strength interference method. Fatigue-reliability-based optimal design of the stage was then conducted using the genetic algorithm and MATLAB. To make fatigue life testing easier, a 1 DOF stage was then optimized and manufactured. Experimental results demonstrate the validity of the approach.

  20. Combinatorial library-based design with Basis Products

    NASA Astrophysics Data System (ADS)

    Zhou, Joe Zhongxiang; Shi, Shenghua; Na, Jim; Peng, Zhengwei; Thacher, Tom

    2009-10-01

    Uncovering useful lead compounds from a vast virtual library of synthesizable compounds continues to be of tremendous interest to pharmaceutical researchers. Here we present the concept of Basis Products (BPs), a new and broadly applicable method for achieving efficient selections from a combinatorial library. By definition, Basis Products are a strategically selected subset of compounds from a potentially very large combinatorial library, and any compound in a combinatorial library can represented by its BPs. In this article we will show how to use BP docking scores to find the top compounds of a combinatorial library. Compared with the brute-force docking of an entire virtual library, docking with BPs are much more efficient because of the substantial size reduction, saving both time and resources. We will also demonstrate how BPs can be used for property-based combinatorial library designs. Furthermore, BPs can also be considered as fragments carrying chemistry knowledge, hence they can potentially be used in combination with any fragment-based design method. Therefore, BPs can be used to integrate combinatorial design with structure-based design and/or fragment-based design. Other potential applications of BPs include lead hopping and consensus core building, which we will describe briefly as well in this report.

  1. Partial gravity habitat study: With application to lunar base design

    NASA Technical Reports Server (NTRS)

    Capps, Stephen; Lorandos, Jason; Akhidime, Eval; Bunch, Michael; Lund, Denise; Moore, Nathan; Murakawa, Kio; Bell, Larry; Trotti, Guillermo; Neubek, Deb

    1989-01-01

    Comprehensive design requirements associated with designing habitats for humans in a partial gravity environment were investigated and then applied to a lunar base design. Other potential sites for application include planetary surfaces such as Mars, variable gravity research facilities, or a rotating spacecraft. Design requirements for partial gravity environments include: (1) locomotion changes in less than normal Earth gravity; (2) facility design issues, such as interior configuration, module diameter and geometry; and (3) volumetric requirements based on the previous as well as psychological issues involved in prolonged isolation. For application to a Lunar Base, it was necessary to study the exterior architecture and configuration to insure optimum circulation patterns while providing dual egress. Radiation protection issues were addressed to provide a safe and healthy environment for the crew, and finally, the overall site was studied to locate all associated facilities in context with the habitat. Mission planning was not the purpose of this study; therefore, a Lockheed scenario was used as an outline for the Lunar Base application, which was then modified to meet the project needs.

  2. Lunar base launch and landing facilities conceptual design

    NASA Technical Reports Server (NTRS)

    Phillips, Paul G.; Simonds, Charles H.; Stump, William R.

    1992-01-01

    The purpose of this study was to perform a first look at the requirements for launch and landing facilities for early lunar bases and to prepared conceptual designs for some of these facilities. The emphasis of the study is on the facilities needed from the first manned landing until permanent occupancy, the Phase 2 lunar base. Factors including surface characteristics, navigation system, engine blast effects, and expected surface operations are used to develop landing pad designs, and definitions fo various other elements of the launch and landing facilities. Finally, the dependence of the use of these elements and the evolution of the facilities are established.

  3. CFD-Based Design Optimization for Single Element Rocket Injector

    NASA Technical Reports Server (NTRS)

    Vaidyanathan, Rajkumar; Tucker, Kevin; Papila, Nilay; Shyy, Wei

    2003-01-01

    To develop future Reusable Launch Vehicle concepts, we have conducted design optimization for a single element rocket injector, with overall goals of improving reliability and performance while reducing cost. Computational solutions based on the Navier-Stokes equations, finite rate chemistry, and the k-E turbulence closure are generated with design of experiment techniques, and the response surface method is employed as the optimization tool. The design considerations are guided by four design objectives motivated by the consideration in both performance and life, namely, the maximum temperature on the oxidizer post tip, the maximum temperature on the injector face, the adiabatic wall temperature, and the length of the combustion zone. Four design variables are selected, namely, H2 flow angle, H2 and O2 flow areas with fixed flow rates, and O2 post tip thickness. In addition to establishing optimum designs by varying emphasis on the individual objectives, better insight into the interplay between design variables and their impact on the design objectives is gained. The investigation indicates that improvement in performance or life comes at the cost of the other. Best compromise is obtained when improvements in both performance and life are given equal importance.

  4. A knowledge-based system design/information tool

    NASA Technical Reports Server (NTRS)

    Allen, James G.; Sikora, Scott E.

    1990-01-01

    The objective of this effort was to develop a Knowledge Capture System (KCS) for the Integrated Test Facility (ITF) at the Dryden Flight Research Facility (DFRF). The DFRF is a NASA Ames Research Center (ARC) facility. This system was used to capture the design and implementation information for NASA's high angle-of-attack research vehicle (HARV), a modified F/A-18A. In particular, the KCS was used to capture specific characteristics of the design of the HARV fly-by-wire (FBW) flight control system (FCS). The KCS utilizes artificial intelligence (AI) knowledge-based system (KBS) technology. The KCS enables the user to capture the following characteristics of automated systems: the system design; the hardware (H/W) design and implementation; the software (S/W) design and implementation; and the utilities (electrical and hydraulic) design and implementation. A generic version of the KCS was developed which can be used to capture the design information for any automated system. The deliverable items for this project consist of the prototype generic KCS and an application, which captures selected design characteristics of the HARV FCS.

  5. Multi-mode reliability-based design of horizontal curves.

    PubMed

    Essa, Mohamed; Sayed, Tarek; Hussein, Mohamed

    2016-08-01

    Recently, reliability analysis has been advocated as an effective approach to account for uncertainty in the geometric design process and to evaluate the risk associated with a particular design. In this approach, a risk measure (e.g. probability of noncompliance) is calculated to represent the probability that a specific design would not meet standard requirements. The majority of previous applications of reliability analysis in geometric design focused on evaluating the probability of noncompliance for only one mode of noncompliance such as insufficient sight distance. However, in many design situations, more than one mode of noncompliance may be present (e.g. insufficient sight distance and vehicle skidding at horizontal curves). In these situations, utilizing a multi-mode reliability approach that considers more than one failure (noncompliance) mode is required. The main objective of this paper is to demonstrate the application of multi-mode (system) reliability analysis to the design of horizontal curves. The process is demonstrated by a case study of Sea-to-Sky Highway located between Vancouver and Whistler, in southern British Columbia, Canada. Two noncompliance modes were considered: insufficient sight distance and vehicle skidding. The results show the importance of accounting for several noncompliance modes in the reliability model. The system reliability concept could be used in future studies to calibrate the design of various design elements in order to achieve consistent safety levels based on all possible modes of noncompliance.

  6. Pharmacology Goes Concept-Based: Course Design, Implementation, and Evaluation.

    PubMed

    Lanz, Amelia; Davis, Rebecca G

    Although concept-based curricula are frequently discussed in the nursing education literature, little information exists to guide the development of a concept-based pharmacology course. Traditionally, nursing pharmacology courses are taught with an emphasis on drug class where a prototype drug serves as an exemplar. When transitioning pharmacology to a concept-based course, special considerations are in order. How can educators successfully integrate essential pharmacological content into a curriculum structured around nursing concepts? This article presents one approach to the design and implementation of a concept-based undergraduate pharmacology course. Planning methods, supportive teaching strategies, and course evaluation procedures are discussed.

  7. Cradle Enhanced UI Development

    NASA Technical Reports Server (NTRS)

    Jentsch, Samuel

    2016-01-01

    This summer I have been working in the EDI (Exploration, Development, and Integration) office. The primary goal of my office is to facilitate the integration, cooperation, and communication between programs, projects and departments throughout the agency. The majority of my efforts has been focused on Cradle, a requirements management and systems engineering tool. This tool is utilized by teams throughout NASA to plan and track the development of a variety of ongoing projects.

  8. An evolutionary based Bayesian design optimization approach under incomplete information

    NASA Astrophysics Data System (ADS)

    Srivastava, Rupesh; Deb, Kalyanmoy

    2013-02-01

    Design optimization in the absence of complete information about uncertain quantities has been recently gaining consideration, as expensive repetitive computation tasks are becoming tractable due to the invention of faster and parallel computers. This work uses Bayesian inference to quantify design reliability when only sample measurements of the uncertain quantities are available. A generalized Bayesian reliability based design optimization algorithm has been proposed and implemented for numerical as well as engineering design problems. The approach uses an evolutionary algorithm (EA) to obtain a trade-off front between design objectives and reliability. The Bayesian approach provides a well-defined link between the amount of available information and the reliability through a confidence measure, and the EA acts as an efficient optimizer for a discrete and multi-dimensional objective space. Additionally, a GPU-based parallelization study shows computational speed-up of close to 100 times in a simulated scenario wherein the constraint qualification checks may be time consuming and could render a sequential implementation that can be impractical for large sample sets. These results show promise for the use of a parallel implementation of EAs in handling design optimization problems under uncertainties.

  9. Decomposition-Based Decision Making for Aerospace Vehicle Design

    NASA Technical Reports Server (NTRS)

    Borer, Nicholas K.; Mavris, DImitri N.

    2005-01-01

    reader to observe how this technique can be applied to aerospace systems design and compare the results of this so-called Decomposition-Based Decision Making to more traditional design approaches.

  10. Design of Adaptive Organizations for Effects Based Operations

    DTIC Science & Technology

    2009-04-04

    COAs. In a sense , it provides a mechanism to assess various COAs based upon comparisons of the change in the probability of key effects over time. It...COVERED (From - To) 1 Oct 2005 to 30 Sept 2008 4. TITLE AND SUBTITLE Design of Adaptive Organizations for Effects Based Operations 5a. CONTRACT NUMBER...result in achieving desired effects . Model Driven Experimentaion was used to develop and assess measures for evaluating the extent of to which effecst

  11. Introduction to Neutron Coincidence Counter Design Based on Boron-10

    SciTech Connect

    Kouzes, Richard T.; Ely, James H.; Lintereur, Azaree T.; Siciliano, Edward R.

    2012-01-22

    The Department of Energy Office of Nonproliferation Policy (NA-241) is supporting the project 'Coincidence Counting With Boron-Based Alternative Neutron Detection Technology' at Pacific Northwest National Laboratory (PNNL) for development of an alternative neutron coincidence counter. The goal of this project is ultimately to design, build and demonstrate a boron-lined proportional tube based alternative system in the configuration of a coincidence counter. This report, providing background information for this project, is the deliverable under Task 1 of the project.

  12. Research and design of logistical information system based on SOA

    NASA Astrophysics Data System (ADS)

    Zhang, Bo

    2013-03-01

    Through the study on the existing logistics information systems and SOA technology, based on the current situation of enterprise logistics management and business features, this paper puts forward a SOA-based logistics system design program. This program is made in the WCF framework, with the combination of SOA and the actual characteristics of logistics enterprises, is simple to realize, easy to operate, and has strong expansion characteristic, therefore has high practical value.

  13. Structure-based design of combinatorial mutagenesis libraries

    PubMed Central

    Verma, Deeptak; Grigoryan, Gevorg; Bailey-Kellogg, Chris

    2015-01-01

    The development of protein variants with improved properties (thermostability, binding affinity, catalytic activity, etc.) has greatly benefited from the application of high-throughput screens evaluating large, diverse combinatorial libraries. At the same time, since only a very limited portion of sequence space can be experimentally constructed and tested, an attractive possibility is to use computational protein design to focus libraries on a productive portion of the space. We present a general-purpose method, called “Structure-based Optimization of Combinatorial Mutagenesis” (SOCoM), which can optimize arbitrarily large combinatorial mutagenesis libraries directly based on structural energies of their constituents. SOCoM chooses both positions and substitutions, employing a combinatorial optimization framework based on library-averaged energy potentials in order to avoid explicitly modeling every variant in every possible library. In case study applications to green fluorescent protein, β-lactamase, and lipase A, SOCoM optimizes relatively small, focused libraries whose variants achieve energies comparable to or better than previous library design efforts, as well as larger libraries (previously not designable by structure-based methods) whose variants cover greater diversity while still maintaining substantially better energies than would be achieved by representative random library approaches. By allowing the creation of large-scale combinatorial libraries based on structural calculations, SOCoM promises to increase the scope of applicability of computational protein design and improve the hit rate of discovering beneficial variants. While designs presented here focus on variant stability (predicted by total energy), SOCoM can readily incorporate other structure-based assessments, such as the energy gap between alternative conformational or bound states. PMID:25611189

  14. Structure-based design of combinatorial mutagenesis libraries.

    PubMed

    Verma, Deeptak; Grigoryan, Gevorg; Bailey-Kellogg, Chris

    2015-05-01

    The development of protein variants with improved properties (thermostability, binding affinity, catalytic activity, etc.) has greatly benefited from the application of high-throughput screens evaluating large, diverse combinatorial libraries. At the same time, since only a very limited portion of sequence space can be experimentally constructed and tested, an attractive possibility is to use computational protein design to focus libraries on a productive portion of the space. We present a general-purpose method, called "Structure-based Optimization of Combinatorial Mutagenesis" (SOCoM), which can optimize arbitrarily large combinatorial mutagenesis libraries directly based on structural energies of their constituents. SOCoM chooses both positions and substitutions, employing a combinatorial optimization framework based on library-averaged energy potentials in order to avoid explicitly modeling every variant in every possible library. In case study applications to green fluorescent protein, β-lactamase, and lipase A, SOCoM optimizes relatively small, focused libraries whose variants achieve energies comparable to or better than previous library design efforts, as well as larger libraries (previously not designable by structure-based methods) whose variants cover greater diversity while still maintaining substantially better energies than would be achieved by representative random library approaches. By allowing the creation of large-scale combinatorial libraries based on structural calculations, SOCoM promises to increase the scope of applicability of computational protein design and improve the hit rate of discovering beneficial variants. While designs presented here focus on variant stability (predicted by total energy), SOCoM can readily incorporate other structure-based assessments, such as the energy gap between alternative conformational or bound states.

  15. A Simulation-Based LED Design Project in Photonics Instruction Based on Industry-University Collaboration

    ERIC Educational Resources Information Center

    Chang, S. -H.; Chen, M. -L.; Kuo, Y. -K.; Shen, Y. -C.

    2011-01-01

    In response to the growing industrial demand for light-emitting diode (LED) design professionals, based on industry-university collaboration in Taiwan, this paper develops a novel instructional approach: a simulation-based learning course with peer assessment to develop students' professional skills in LED design as required by industry as well as…

  16. A Simulation-Based LED Design Project in Photonics Instruction Based on Industry-University Collaboration

    ERIC Educational Resources Information Center

    Chang, S. -H.; Chen, M. -L.; Kuo, Y. -K.; Shen, Y. -C.

    2011-01-01

    In response to the growing industrial demand for light-emitting diode (LED) design professionals, based on industry-university collaboration in Taiwan, this paper develops a novel instructional approach: a simulation-based learning course with peer assessment to develop students' professional skills in LED design as required by industry as well as…

  17. Model-Based Design of Tree WSNs for Decentralized Detection.

    PubMed

    Tantawy, Ashraf; Koutsoukos, Xenofon; Biswas, Gautam

    2015-08-20

    The classical decentralized detection problem of finding the optimal decision rules at the sensor and fusion center, as well as variants that introduce physical channel impairments have been studied extensively in the literature. The deployment of WSNs in decentralized detection applications brings new challenges to the field. Protocols for different communication layers have to be co-designed to optimize the detection performance. In this paper, we consider the communication network design problem for a tree WSN. We pursue a system-level approach where a complete model for the system is developed that captures the interactions between different layers, as well as different sensor quality measures. For network optimization, we propose a hierarchical optimization algorithm that lends itself to the tree structure, requiring only local network information. The proposed design approach shows superior performance over several contentionless and contention-based network design approaches.

  18. Prodrugs design based on inter- and intramolecular chemical processes.

    PubMed

    Karaman, Rafik

    2013-12-01

    This review provides the reader a concise overview of the majority of prodrug approaches with the emphasis on the modern approaches to prodrug design. The chemical approach catalyzed by metabolic enzymes which is considered as widely used among all other approaches to minimize the undesirable drug physicochemical properties is discussed. Part of this review will shed light on the use of molecular orbital methods such as DFT, semiempirical and ab initio for the design of novel prodrugs. This novel prodrug approach implies prodrug design based on enzyme models that were utilized for mimicking enzyme catalysis. The computational approach exploited for the prodrug design involves molecular orbital and molecular mechanics (DFT, ab initio, and MM2) calculations and correlations between experimental and calculated values of intramolecular processes that were experimentally studied to assign the factors determining the reaction rates in certain processes for better understanding on how enzymes might exert their extraordinary catalysis.

  19. Design of a vehicle based system to prevent ozone loss

    NASA Technical Reports Server (NTRS)

    Talbot, Matthew D.; Eby, Steven C.; Ireland, Glen J.; Mcwithey, Michael C.; Schneider, Mark S.; Youngblood, Daniel L.; Johnson, Matt; Taylor, Chris

    1994-01-01

    This project is designed to be completed over a three year period. Overall project goals are: (1) to understand the processes that contribute to stratospheric ozone loss; (2) to determine the best scheme to prevent ozone loss; and (3) to design a vehicle based system to carry out the prevention scheme. The 1993/1994 design objectives included: (1) to review the results of the 1992/1993 design team, including a reevaluation of the key assumptions used; (2) to develop a matrix of baseline vehicle concepts as candidates for the delivery vehicle; and (3) to develop a selection criteria and perform quantitative trade studies to use in the selection of the specific vehicle concept.

  20. Design Optimization of Liquid Nitrogen Based IQF Tunnel

    NASA Astrophysics Data System (ADS)

    Datye, A. B.; Narayankhedkar, K. G.; Sharma, G. K.

    2006-04-01

    A design methodology for an Individual Quick Freezing (IQF) tunnel using liquid nitrogen is developed and the design based on this methodology is validated using the data of commercial tunnels. The design takes care of heat gains due to the conveyor belt which is exposed to atmosphere at the infeed and outfeed ends. The design also considers the heat gains through the insulation as well as due to circulating fans located within the tunnel. For minimum liquid nitrogen consumption, the ratio of the length of the belt, L (from infeed to out feed) to the width of the belt, W can be considered as a parameter. The comparison of predicted and reported liquid nitrogen (experimental data) consumption shows good agreement and is within 10 %.

  1. Adjoint-Based Aerodynamic Design of Complex Aerospace Configurations

    NASA Technical Reports Server (NTRS)

    Nielsen, Eric J.

    2016-01-01

    An overview of twenty years of adjoint-based aerodynamic design research at NASA Langley Research Center is presented. Adjoint-based algorithms provide a powerful tool for efficient sensitivity analysis of complex large-scale computational fluid dynamics (CFD) simulations. Unlike alternative approaches for which computational expense generally scales with the number of design parameters, adjoint techniques yield sensitivity derivatives of a simulation output with respect to all input parameters at the cost of a single additional simulation. With modern large-scale CFD applications often requiring millions of compute hours for a single analysis, the efficiency afforded by adjoint methods is critical in realizing a computationally tractable design optimization capability for such applications.

  2. Single-Subject Experimental Design for Evidence-Based Practice

    PubMed Central

    Byiers, Breanne J.; Reichle, Joe; Symons, Frank J.

    2014-01-01

    Purpose Single-subject experimental designs (SSEDs) represent an important tool in the development and implementation of evidence-based practice in communication sciences and disorders. The purpose of this article is to review the strategies and tactics of SSEDs and their application in speech-language pathology research. Method The authors discuss the requirements of each design, followed by advantages and disadvantages. The logic and methods for evaluating effects in SSED are reviewed as well as contemporary issues regarding data analysis with SSED data sets. Examples of challenges in executing SSEDs are included. Specific exemplars of how SSEDs have been used in speech-language pathology research are provided throughout. Conclusion SSED studies provide a flexible alternative to traditional group designs in the development and identification of evidence-based practice in the field of communication sciences and disorders. PMID:23071200

  3. Shell Buckling Design Criteria Based on Manufacturing Imperfection Signatures

    NASA Technical Reports Server (NTRS)

    Hilburger, Mark W.; Nemeth, Michael P.; Starnes, James H., Jr.

    2004-01-01

    An analysis-based approach .for developing shell-buckling design criteria for laminated-composite cylindrical shells that accurately accounts for the effects of initial geometric imperfections is presented. With this approach, measured initial geometric imperfection data from six graphite-epoxy shells are used to determine a manufacturing-process-specific imperfection signature for these shells. This imperfection signature is then used as input into nonlinear finite-element analyses. The imperfection signature represents a "first-approximation" mean imperfection shape that is suitable for developing preliminary-design data. Comparisons of test data and analytical results obtained by using several different imperfection shapes are presented for selected shells. Overall, the results indicate that the analysis-based approach presented for developing reliable preliminary-design criteria has the potential to provide improved, less conservative buckling-load estimates, and to reduce the weight and cost of developing buckling-resistant shell structures.

  4. Fragment-based design of kinase inhibitors: a practical guide.

    PubMed

    Erickson, Jon A

    2015-01-01

    Fragment-based drug design has become an important strategy for drug design and development over the last decade. It has been used with particular success in the development of kinase inhibitors, which are one of the most widely explored classes of drug targets today. The application of fragment-based methods to discovering and optimizing kinase inhibitors can be a complicated and daunting task; however, a general process has emerged that has been highly fruitful. Here a practical outline of the fragment process used in kinase inhibitor design and development is laid out with specific examples. A guide to the overall process from initial discovery through fragment screening, including the difficulties in detection, to the computational methods available for use in optimization of the discovered fragments is reported.

  5. Design and performance comparison of fuzzy logic based tracking controllers

    NASA Technical Reports Server (NTRS)

    Lea, Robert N.; Jani, Yashvant

    1992-01-01

    Several camera tracking controllers based on fuzzy logic principles have been designed and tested in software simulation in the software technology branch at the Johnson Space Center. The fuzzy logic based controllers utilize range measurement and pixel positions from the image as input parameters and provide pan and tilt gimble rate commands as output. Two designs of the rulebase and tuning process applied to the membership functions are discussed in light of optimizing performance. Seven test cases have been designed to test the performance of the controllers for proximity operations where approaches like v-bar, fly-around and station keeping are performed. The controllers are compared in terms of responsiveness, and ability to maintain the object in the field-of-view of the camera. Advantages of the fuzzy logic approach with respect to the conventional approach have been discussed in terms of simplicity and robustness.

  6. Uniform design based SVM model selection for face recognition

    NASA Astrophysics Data System (ADS)

    Li, Weihong; Liu, Lijuan; Gong, Weiguo

    2010-02-01

    Support vector machine (SVM) has been proved to be a powerful tool for face recognition. The generalization capacity of SVM depends on the model with optimal hyperparameters. The computational cost of SVM model selection results in application difficulty in face recognition. In order to overcome the shortcoming, we utilize the advantage of uniform design--space filling designs and uniformly scattering theory to seek for optimal SVM hyperparameters. Then we propose a face recognition scheme based on SVM with optimal model which obtained by replacing the grid and gradient-based method with uniform design. The experimental results on Yale and PIE face databases show that the proposed method significantly improves the efficiency of SVM model selection.

  7. Zeroth order resonator (ZOR) based RFID antenna design

    NASA Astrophysics Data System (ADS)

    Masud, Muhammad Mubeen

    Meander-line and multi-layer antennas have been used extensively to design compact UHF radio frequency identification (RFID) tags; however the overall size reduction of meander-line antennas is limited by the amount of parasitic inductance that can be introduced by each meander-line segment, and multi-layer antennas can be too costly. In this study, a new compact antenna topology for passive UHF RFID tags based on zeroth order resonant (ZOR) design techniques is presented. The antenna consists of lossy coplanar conductors and either inter-connected inter-digital capacitor (IDC) or shunt inductor unit-cells with a ZOR frequency near the operating frequency of the antenna. Setting the ZOR frequency near the operating frequency is a key component in the design process because the unit-cells chosen for the design are inductive at the operating frequency. This makes the unit-cells very useful for antenna miniaturization. These new designs in this work have several benefits: the coplanar layout can be printed on a single layer, matching inductive loops that reduce antenna efficiency are not required and ZOR analysis can be used for the design. Finally, for validation, prototype antennas are designed, fabricated and tested.

  8. Teaching Soils Online Using a Problem-Based Learning Design.

    ERIC Educational Resources Information Center

    McAlpine, Iain; Dudley, Nick

    Problem-based learning (PBL) was used as the instructional design basis for a TAFE (Technical and Further Education) unit of competency developed for online delivery. The courseware was commissioned to provide online content for users of the Victorian TAFE Virtual Campus (Australia). The aim of the project was to provide courseware that would…

  9. Designing a Virtual-Reality-Based, Gamelike Math Learning Environment

    ERIC Educational Resources Information Center

    Xu, Xinhao; Ke, Fengfeng

    2016-01-01

    This exploratory study examined the design issues related to a virtual-reality-based, gamelike learning environment (VRGLE) developed via OpenSimulator, an open-source virtual reality server. The researchers collected qualitative data to examine the VRGLE's usability, playability, and content integration for math learning. They found it important…

  10. Preliminary design document: Ground based testbed for avionics systems

    NASA Technical Reports Server (NTRS)

    1989-01-01

    The design and interface requirements for an avionics Ground Based Test bed (GBT) to support Heavy Lift Cargo Vehicles (HLCV) is presented. It also contains data on the vehicle subsystem configurations that are to be supported during their early, pre-PDR developmental phases. Several emerging technologies are also identified for support. A Preliminary Specification Tree is also presented.

  11. Educational Facility Design and Project Based Learning: "The Real Connection"

    ERIC Educational Resources Information Center

    Schrader, David L.; Sole, John

    2009-01-01

    There is a case to be made for the integration of the Project Based Service Learning (PBSL) process and the design and construction of educational facilities. A growing body of research supports the notion that the formulaic educational system of the last hundred years may no longer serve the learning styles of new and future generations. Their…

  12. Design of GEO helix tourist orbit based on perturbation compensation

    NASA Astrophysics Data System (ADS)

    Xu, Yanli; Zhou, Haijun; Dai, Huayu

    2017-05-01

    Constrained by country area and technology level, GEO target and environment's detection become practical difficulty which restrict development of our country's space technology. Helix tourist orbit is introduced; orbit formation effect from perturbation of nonsphericfigure of the Earth, the solar and lunar attraction is analyzed; orbit design method based on perturbation compensation is put forward.

  13. Designing Digital Problem Based Learning Tasks that Motivate Students

    ERIC Educational Resources Information Center

    van Loon, Anne-Marieke; Ros, Anje; Martens, Rob

    2013-01-01

    This study examines whether teachers are able to apply the principles of autonomy support and structure support in designing digital problem based learning (PBL) tasks. We examine whether these tasks are more autonomy- and structure-supportive and whether primary and secondary school students experience greater autonomy, competence, and motivation…

  14. Empowering Design-Based Implementation Research: The Need for Infrastructure

    ERIC Educational Resources Information Center

    Sabelli, Nora; Dede, Chris

    2013-01-01

    This chapter discusses frameworks and conceptual lenses that help orient design-based implementation research (DBIR) work to the types of infrastructure required for success, while contributing to theories about the processes of educational improvement. Such infrastructures can be conceived as a framework: a set of interconnected elements that…

  15. Single-Subject Experimental Design for Evidence-Based Practice

    ERIC Educational Resources Information Center

    Byiers, Breanne J.; Reichle, Joe; Symons, Frank J.

    2012-01-01

    Purpose: Single-subject experimental designs (SSEDs) represent an important tool in the development and implementation of evidence-based practice in communication sciences and disorders. The purpose of this article is to review the strategies and tactics of SSEDs and their application in speech-language pathology research. Method: The authors…

  16. Design Model for Learner-Centered, Computer-Based Simulations.

    ERIC Educational Resources Information Center

    Hawley, Chandra L.; Duffy, Thomas M.

    This paper presents a model for designing computer-based simulation environments within a constructivist framework for the K-12 school setting. The following primary criteria for the development of simulations are proposed: (1) the problem needs to be authentic; (2) the cognitive demand in learning should be authentic; (3) scaffolding supports a…

  17. A Problem-Based Learning Design for Teaching Biochemistry.

    ERIC Educational Resources Information Center

    Dods, Richard F.

    1996-01-01

    Describes the design of a biochemistry course that uses problem-based learning. Provides opportunities for students to question, dispute, confirm, and disconfirm their understanding of basic concepts. Emphasizes self-correction through dialogue. Topics covered include amino acids, metabolic pathways and inherited disease, proteins, enzymes and…

  18. Designing a Knowledge Base for Automatic Book Classification.

    ERIC Educational Resources Information Center

    Kim, Jeong-Hyen; Lee, Kyung-Ho

    2002-01-01

    Reports on the design of a knowledge base for an automatic classification in the library science field by using the facet classification principles of colon classification. Discusses inputting titles or key words into the computer to create class numbers through automatic subject recognition and processing title key words. (Author/LRW)

  19. Teaching Construction: A Design-Based Course Model

    ERIC Educational Resources Information Center

    Love, Tyler S.; Salgado, Carlos A.

    2016-01-01

    The focus on construction in T&E education has drastically changed. This article presents a series of topics and design-based labs that can be taught at various grade levels to integrate STEM concepts while also increasing students' overall awareness of construction and structural technologies.

  20. A Context Awareness System for Online Learning: Design Based Research

    ERIC Educational Resources Information Center

    Laffey, James; Amelung, Chris; Goggins, Sean

    2009-01-01

    A design based research strategy examining the impressions and behavior of members of courses taught entirely online is used for refining a context-aware activity notification system (CANS). The findings show that CANS must address substantial variety in courses and members while also fitting with multitasking between online and real world…

  1. Designing a Knowledge Base for Automatic Book Classification.

    ERIC Educational Resources Information Center

    Kim, Jeong-Hyen; Lee, Kyung-Ho

    2002-01-01

    Reports on the design of a knowledge base for an automatic classification in the library science field by using the facet classification principles of colon classification. Discusses inputting titles or key words into the computer to create class numbers through automatic subject recognition and processing title key words. (Author/LRW)

  2. Designing a Virtual-Reality-Based, Gamelike Math Learning Environment

    ERIC Educational Resources Information Center

    Xu, Xinhao; Ke, Fengfeng

    2016-01-01

    This exploratory study examined the design issues related to a virtual-reality-based, gamelike learning environment (VRGLE) developed via OpenSimulator, an open-source virtual reality server. The researchers collected qualitative data to examine the VRGLE's usability, playability, and content integration for math learning. They found it important…

  3. Teaching Construction: A Design-Based Course Model

    ERIC Educational Resources Information Center

    Love, Tyler S.; Salgado, Carlos A.

    2016-01-01

    The focus on construction in T&E education has drastically changed. This article presents a series of topics and design-based labs that can be taught at various grade levels to integrate STEM concepts while also increasing students' overall awareness of construction and structural technologies.

  4. Design Based Research Methodology for Teaching with Technology in English

    ERIC Educational Resources Information Center

    Jetnikoff, Anita

    2015-01-01

    Design based research (DBR) is an appropriate method for small scale educational research projects involving collaboration between teachers, students and researchers. It is particularly useful in collaborative projects where an intervention is implemented and evaluated in a grounded context. The intervention can be technological, or a new program…

  5. A Problem-Based Learning Design for Teaching Biochemistry.

    ERIC Educational Resources Information Center

    Dods, Richard F.

    1996-01-01

    Describes the design of a biochemistry course that uses problem-based learning. Provides opportunities for students to question, dispute, confirm, and disconfirm their understanding of basic concepts. Emphasizes self-correction through dialogue. Topics covered include amino acids, metabolic pathways and inherited disease, proteins, enzymes and…

  6. Designing Digital Problem Based Learning Tasks that Motivate Students

    ERIC Educational Resources Information Center

    van Loon, Anne-Marieke; Ros, Anje; Martens, Rob

    2013-01-01

    This study examines whether teachers are able to apply the principles of autonomy support and structure support in designing digital problem based learning (PBL) tasks. We examine whether these tasks are more autonomy- and structure-supportive and whether primary and secondary school students experience greater autonomy, competence, and motivation…

  7. Reliability-Based Design Optimization Using Buffered Failure Probability

    DTIC Science & Technology

    2010-06-01

    missile. One component of the missile’s launcher is an optical system. Suppose that two different optical systems, 1 and 2, are available for...ed.). Belmont, MA: Athena Scientific. Bichon, B. J., Mahadevan, S., & Eldred, M. S. (May 4–7, 2009). Reliability-based design optimization using

  8. The Design Consideration for Game-Based Learning

    ERIC Educational Resources Information Center

    Liang, Chaoyun; Lee, Yuan-Zone; Chou, Wen-Shou

    2010-01-01

    The integration of game playing with online education has recently become one of the most discussed issues in the e-learning field for its potentially positive impact on the development of related industries and on the social lives of young people. In this article, the authors propose a set of design considerations to assist game-based learning…

  9. Design Considerations in Developing a Web-Based Mentor Network.

    ERIC Educational Resources Information Center

    Sumner, Todd

    This paper describes a Web-based mentor network designed to pair students in rural independent schools with undergraduates at selected liberal arts colleges. It is one of nine central program elements that constitute the Proteus(TM) system, a multimedia technologies architecture that supports distributed collaborations and work undertaken in the…

  10. Single-Subject Experimental Design for Evidence-Based Practice

    ERIC Educational Resources Information Center

    Byiers, Breanne J.; Reichle, Joe; Symons, Frank J.

    2012-01-01

    Purpose: Single-subject experimental designs (SSEDs) represent an important tool in the development and implementation of evidence-based practice in communication sciences and disorders. The purpose of this article is to review the strategies and tactics of SSEDs and their application in speech-language pathology research. Method: The authors…

  11. The Design of a Computer Based Education System, Volume I.

    ERIC Educational Resources Information Center

    Mitchell, Maurice; And Others

    A research project was conducted by Des Moines Area Community College (DMACC) to investigate the computer-based education (CBE) needs of DMACC, design a CBE system to meet those needs, provide a plan for implementing that system, and justify implementation costs. The project report begins by discussing initial planning activities, including…

  12. Redesigning Vocational Education: The Possibilities of Design-Based Research

    ERIC Educational Resources Information Center

    Leeman, Yvonne; Wardekker, Willem

    2011-01-01

    This article describes and reflects our experiences as researchers in a design-based research project on a curriculum innovation focused on meaningful, co-operative learning in vocational education in the Netherlands. The project was successful in gaining insights in possible practices for workplace learning but did only partly realize the…

  13. Design Based Research Methodology for Teaching with Technology in English

    ERIC Educational Resources Information Center

    Jetnikoff, Anita

    2015-01-01

    Design based research (DBR) is an appropriate method for small scale educational research projects involving collaboration between teachers, students and researchers. It is particularly useful in collaborative projects where an intervention is implemented and evaluated in a grounded context. The intervention can be technological, or a new program…

  14. Empowering Design-Based Implementation Research: The Need for Infrastructure

    ERIC Educational Resources Information Center

    Sabelli, Nora; Dede, Chris

    2013-01-01

    This chapter discusses frameworks and conceptual lenses that help orient design-based implementation research (DBIR) work to the types of infrastructure required for success, while contributing to theories about the processes of educational improvement. Such infrastructures can be conceived as a framework: a set of interconnected elements that…

  15. Proficiency-Based Curriculum Design: Principles Derived from Government Experience.

    ERIC Educational Resources Information Center

    Lowe, Pardee, Jr.

    1985-01-01

    Describes principles for designing a proficiency-based course to prepare students for the ACTFL/ETS Advanced Plus/Superior level according to Interagency Language Roundtable guidelines. Proposes ways to combine grammatical and "functional/notional" syllabuses with a proficiency approach. Examines the implications of these principles for…

  16. Using Design-Based Research in Gifted Education

    ERIC Educational Resources Information Center

    Jen, Enyi; Moon, Sidney; Samarapungavan, Ala

    2015-01-01

    Design-based research (DBR) is a new methodological framework that was developed in the context of the learning sciences; however, it has not been used very often in the field of gifted education. Compared with other methodologies, DBR is more process-oriented and context-sensitive. In this methodological brief, the authors introduce DBR and…

  17. Coverage estimation-based system design in wireless communications

    NASA Astrophysics Data System (ADS)

    Aktul, Kavas

    2004-04-01

    A coverage estimation based cellular system design in microcell structure under shadowing and multipath conditions is presented. The effect of the signal weakening conditions is examined by log-normal shadowing/Rayleigh fading distribution. By taking the application values of GSM operating systems and cellular phones, area reliability and cell radius are calculated and reliable RF coverage is investigated.

  18. Knowledge-based optical coatings design and manufacturing

    NASA Astrophysics Data System (ADS)

    Guenther, Karl H.; Gonzalez, Avelino J.; Yoo, Hoi J.

    1990-12-01

    The theory of thin film optics is well developed for the spectral analysis of a given optical coating. The inverse synthesis - designing an optical coating for a certain spectral performance - is more complicated. Usually a multitude of theoretical designs is feasible because most design problems are over-determined with the number of layers possible with three variables each (n, k, t). The expertise of a good thin film designer comes in at this point with a mostly intuitive selection of certain designs based on previous experience and current manufacturing capabilities. Manufacturing a designed coating poses yet another subset of multiple solutions, as thin if in deposition technology has evolved over the years with a vast variety of different processes. The abundance of published literature may often be more confusing than helpful to the practicing thin film engineer, even if he has time and opportunity to read it. The choice of the right process is also severely limited by the given manufacturing hardware and cost considerations which may not easily allow for the adaption of a new manufacturing approach, even if it promises to be better technically (it ought to be also cheaper). On the user end of the thin film coating business, the typical optical designer or engineer who needs an optical coating may have limited or no knowledge at all about the theoretical and manufacturing criteria for the optimum selection of what he needs. This can be sensed frequently by overly tight tolerances and requirements for optical performance which sometimes stretch the limits of mother nature. We introduce here a know1edge-based system (KBS) intended to assist expert designers and manufacturers in their task of maximizing results and minimizing errors, trial runs, and unproductive time. It will help the experts to manipulate parameters which are largely determined through heuristic reasoning by employing artificial intelligence techniques. In a later state, the KBS will include a

  19. Internet MEMS design tools based on component technology

    NASA Astrophysics Data System (ADS)

    Brueck, Rainer; Schumer, Christian

    1999-03-01

    The micro electromechanical systems (MEMS) industry in Europe is characterized by small and medium sized enterprises specialized on products to solve problems in specific domains like medicine, automotive sensor technology, etc. In this field of business the technology driven design approach known from micro electronics is not appropriate. Instead each design problem aims at its own, specific technology to be used for the solution. The variety of technologies at hand, like Si-surface, Si-bulk, LIGA, laser, precision engineering requires a huge set of different design tools to be available. No single SME can afford to hold licenses for all these tools. This calls for a new and flexible way of designing, implementing and distributing design software. The Internet provides a flexible manner of offering software access along with methodologies of flexible licensing e.g. on a pay-per-use basis. New communication technologies like ADSL, TV cable of satellites as carriers promise to offer a bandwidth sufficient even for interactive tools with graphical interfaces in the near future. INTERLIDO is an experimental tool suite for process specification and layout verification for lithography based MEMS technologies to be accessed via the Internet. The first version provides a Java implementation even including a graphical editor for process specification. Currently, a new version is brought into operation that is based on JavaBeans component technology. JavaBeans offers the possibility to realize independent interactive design assistants, like a design rule checking assistants, a process consistency checking assistants, a technology definition assistants, a graphical editor assistants, etc. that may reside distributed over the Internet, communicating via Internet protocols. Each potential user thus is able to configure his own dedicated version of a design tool set dedicated to the requirements of the current problem to be solved.

  20. A New Design Method based on Cooperative Data Mining from Multi-Objective Design Space

    NASA Astrophysics Data System (ADS)

    Sugimura, Kazuyuki; Obayashi, Shigeru; Jeong, Shinkyu

    We propose a new multi-objective parameter design method that uses the combination of the following data mining techniques: analysis of variance, self-organizing map, decision tree analysis, rough set theory, and association rule. This method first aims to improve multiple objective functions simultaneously using as much predominant main effects of different design variables as possible. Then it resolves the remaining conflictions between the objective functions using predominant interaction effects of design variables. The key to realizing this method is the obtaining of various design rules that quantitatively relate levels of design variables to levels of objective functions. Based on comparative studies of data mining techniques, the systematic processes for obtaining these design rules have been clarified, and the points of combining data mining techniques have also been summarized. This method has been applied to a multi-objective robust optimization problem of an industrial fan, and the results show its superior capabilities for controlling parameters to traditional single-objective parameter design methods like the Taguchi method.

  1. Discovery and design of carbohydrate-based therapeutics.

    PubMed

    Cipolla, Laura; Araújo, Ana C; Bini, Davide; Gabrielli, Luca; Russo, Laura; Shaikh, Nasrin

    2010-08-01

    Till now, the importance of carbohydrates has been underscored, if compared with the two other major classes of biopolymers such as oligonucleotides and proteins. Recent advances in glycobiology and glycochemistry have imparted a strong interest in the study of this enormous family of biomolecules. Carbohydrates have been shown to be implicated in recognition processes, such as cell-cell adhesion, cell-extracellular matrix adhesion and cell-intruder recognition phenomena. In addition, carbohydrates are recognized as differentiation markers and as antigenic determinants. Due to their relevant biological role, carbohydrates are promising candidates for drug design and disease treatment. However, the growing number of human disorders known as congenital disorders of glycosylation that are being identified as resulting from abnormalities in glycan structures and protein glycosylation strongly indicates that a fast development of glycobiology, glycochemistry and glycomedicine is highly desirable. The topics give an overview of different approaches that have been used to date for the design of carbohydrate-based therapeutics; this includes the use of native synthetic carbohydrates, the use of carbohydrate mimics designed on the basis of their native counterpart, the use of carbohydrates as scaffolds and finally the design of glyco-fused therapeutics, one of the most recent approaches. The review covers mainly literature that has appeared since 2000, except for a few papers cited for historical reasons. The reader will gain an overview of the current strategies applied to the design of carbohydrate-based therapeutics; in particular, the advantages/disadvantages of different approaches are highlighted. The topic is presented in a general, basic manner and will hopefully be a useful resource for all readers who are not familiar with it. In addition, in order to stress the potentialities of carbohydrates, several examples of carbohydrate-based marketed therapeutics are given

  2. A Hybrid Tool for User Interface Modeling and Prototyping

    NASA Astrophysics Data System (ADS)

    Trætteberg, Hallvard

    Although many methods have been proposed, model-based development methods have only to some extent been adopted for UI design. In particular, they are not easy to combine with user-centered design methods. In this paper, we present a hybrid UI modeling and GUI prototyping tool, which is designed to fit better with IS development and UI design traditions. The tool includes a diagram editor for domain and UI models and an execution engine that integrates UI behavior, live UI components and sample data. Thus, both model-based user interface design and prototyping-based iterative design are supported

  3. Design-based and model-based inference in surveys of freshwater mollusks

    USGS Publications Warehouse

    Dorazio, R.M.

    1999-01-01

    Well-known concepts in statistical inference and sampling theory are used to develop recommendations for planning and analyzing the results of quantitative surveys of freshwater mollusks. Two methods of inference commonly used in survey sampling (design-based and model-based) are described and illustrated using examples relevant in surveys of freshwater mollusks. The particular objectives of a survey and the type of information observed in each unit of sampling can be used to help select the sampling design and the method of inference. For example, the mean density of a sparsely distributed population of mollusks can be estimated with higher precision by using model-based inference or by using design-based inference with adaptive cluster sampling than by using design-based inference with conventional sampling. More experience with quantitative surveys of natural assemblages of freshwater mollusks is needed to determine the actual benefits of different sampling designs and inferential procedures.

  4. Design Research on Inquiry-Based Multivariable Calculus: Focusing on Students' Argumentation and Instructional Design

    ERIC Educational Resources Information Center

    Kwon, Oh Nam; Bae, Younggon; Oh, Kuk Hwan

    2015-01-01

    In this study, researchers design and implement an inquiry based multivariable calculus course in a university which aims at enhancing students' argumentation in rich mathematical discussions. This research aims to understand the characteristics of students' argumentation in activities involving proof constructions through mathematical…

  5. Designing Collaborative E-Learning Environments Based upon Semantic Wiki: From Design Models to Application Scenarios

    ERIC Educational Resources Information Center

    Li, Yanyan; Dong, Mingkai; Huang, Ronghuai

    2011-01-01

    The knowledge society requires life-long learning and flexible learning environment that enables fast, just-in-time and relevant learning, aiding the development of communities of knowledge, linking learners and practitioners with experts. Based upon semantic wiki, a combination of wiki and Semantic Web technology, this paper designs and develops…

  6. Web Design Curriculum and Syllabus Based on Web Design Practice and Students' Prior Knowledge

    ERIC Educational Resources Information Center

    Krunic, Tanja; Ruzic-Dimitrijevic, Ljiljana; Petrovic, Branka; Farkas, Robert

    2006-01-01

    The Advanced Technical School from Novi Sad set up a completely new study group for web design in 2004. The main goals of the paper are to explain the steps that were taken in starting this group, and to present the educational program based on our own research through the organization of the group and course descriptions. Since there is a…

  7. Designing Collaborative E-Learning Environments Based upon Semantic Wiki: From Design Models to Application Scenarios

    ERIC Educational Resources Information Center

    Li, Yanyan; Dong, Mingkai; Huang, Ronghuai

    2011-01-01

    The knowledge society requires life-long learning and flexible learning environment that enables fast, just-in-time and relevant learning, aiding the development of communities of knowledge, linking learners and practitioners with experts. Based upon semantic wiki, a combination of wiki and Semantic Web technology, this paper designs and develops…

  8. Design Research on Inquiry-Based Multivariable Calculus: Focusing on Students' Argumentation and Instructional Design

    ERIC Educational Resources Information Center

    Kwon, Oh Nam; Bae, Younggon; Oh, Kuk Hwan

    2015-01-01

    In this study, researchers design and implement an inquiry based multivariable calculus course in a university which aims at enhancing students' argumentation in rich mathematical discussions. This research aims to understand the characteristics of students' argumentation in activities involving proof constructions through mathematical…

  9. Web-Based Museum Trails on PDAs for University-Level Design Students: Design and Evaluation

    ERIC Educational Resources Information Center

    Reynolds, R.; Walker, K.; Speight, C.

    2010-01-01

    This paper describes the development and evaluation of web-based museum trails for university-level design students to access on handheld devices in the Victoria and Albert Museum (V&A) in London. The trails offered students a range of ways of exploring the museum environment and collections, some encouraging students to interpret objects and…

  10. Web Design Curriculum and Syllabus Based on Web Design Practice and Students' Prior Knowledge

    ERIC Educational Resources Information Center

    Krunic, Tanja; Ruzic-Dimitrijevic, Ljiljana; Petrovic, Branka; Farkas, Robert

    2006-01-01

    The Advanced Technical School from Novi Sad set up a completely new study group for web design in 2004. The main goals of the paper are to explain the steps that were taken in starting this group, and to present the educational program based on our own research through the organization of the group and course descriptions. Since there is a…

  11. Web-Based Museum Trails on PDAs for University-Level Design Students: Design and Evaluation

    ERIC Educational Resources Information Center

    Reynolds, R.; Walker, K.; Speight, C.

    2010-01-01

    This paper describes the development and evaluation of web-based museum trails for university-level design students to access on handheld devices in the Victoria and Albert Museum (V&A) in London. The trails offered students a range of ways of exploring the museum environment and collections, some encouraging students to interpret objects and…

  12. Use of the International Consultation on Incontinence Questionnaire-Urinary Incontinence-Short Form (ICIQ-UI-SF) for an objective assessment of disability determination according to the Modified Katz Scale: a prospective longitudinal study.

    PubMed

    Timmermans, Luc; Falez, Freddy; Melot, Christian; Higuet, Sandra; Vincent, Denis

    2016-08-01

    The aim of this study was to demonstrate that the International Consultation on Incontinence Questionnaire-Urinary Incontinence-Short Form (ICIQ-UI-SF) tool can be applied for a factual score determining urinary incontinence in the Katz-6 Scale, and it is effective to identify score 2 from score 3. Functional capacity of 63 patients (14 M, 49 F aged from 70 to 99 years old) was evaluated with a Mini Mental State Examination (MMSE), Katz Index for Activities of Daily Living, and ICIQ-UI-SF questionnaire. Mean comparative analysis was performed. ICIQ-UI-SF scores were then entered as variables. These data observed in Katz continence item scored 2 and Katz continence item scored 3 were compared in a combined box-and-whisker and dot plot. Sensitivity and specificity of each variable were tested and results were evaluated using a receiver operating characteristic (ROC) curve. The best variable (ICIQ-UI-SF Score) was retained as a breach permitting to distinguish patients to be scored 2 or 3 over continence Katz item. Statistical analysis demonstrated significant difference between the sample of Katz continence item scored 2 and the sample of Katz continence item scored 3 over the ICIQ-UI-SF Score and the Katz global Score, but the difference was not significant concerning the MMSE Score. Using ROC analysis, we compared the discriminant power of the ICIQ-UI-SF Score for continence Katz item Score. Criterion values and coordinates of the ROC curve were studied and the ICIQ-UI-SF score of 13 was considered the best one. We demonstrated that the best variable (ICIQ-UI-SF Score) to retain as a breach permitting to distinguish patients to be scored 2 or 3 over continence Katz item is 13.

  13. Fragment-based drug design: combining philosophy with technology.

    PubMed

    Bartoli, Sandra; Fincham, Christopher I; Fattori, Daniela

    2007-07-01

    Fragment-based drug design began more than ten years ago and has been steadily gaining in popularity. This review discusses how fragments have been used to choose druggable targets, and what parameters need to be evaluated if a fragment hit is to be considered a suitable ligand for development. Examples of fragment-based screening from the recent literature are reviewed to highlight the various approaches used, along with the possible application of additional techniques to fragment screening against immobilized targets. Finally, mention is made of two different areas, multi-target drug discovery and selective tumor cell targeting, where fragment-based approaches may play an important role in the future.

  14. Rule-based navigation control design for autonomous flight

    NASA Astrophysics Data System (ADS)

    Contreras, Hugo; Bassi, Danilo

    2008-04-01

    This article depicts a navigation control system design that is based on a set of rules in order to follow a desired trajectory. The full control of the aircraft considered here comprises: a low level stability control loop, based on classic PID controller and the higher level navigation whose main job is to exercise lateral control (course) and altitude control, trying to follow a desired trajectory. The rules and PID gains were adjusted systematically according to the result of flight simulation. In spite of its simplicity, the rule-based navigation control proved to be robust, even with big perturbation, like crossing winds.

  15. Human friendly architectural design for a small Martian base

    NASA Astrophysics Data System (ADS)

    Kozicki, J.; Kozicka, J.

    2011-12-01

    The manned mission to Mars is expected to last almost three years. A human factor must be taken seriously into account in such a long-term mission. A big comfortable habitat can help to overcome sociopsychological problems, that occur in ICEs (Isolated and Confined Environments). Authors have come forward to this issue and have developed a Martian base design as a human friendly habitat. The project is based on researches of extreme conditions on Mars, architecture in ICEs and contemporary building technologies. The base consists of five modules: a Central Module (CM), an Agriculture Dome (AD), a Residential Dome (RD), a Laboratory Dome (LD) and a Garage (G). Each element has its own functional purpose. The CM is a metal capsule similar to the Reference Mission module (RM, NASA, 1997). Domes are inflatable multilayer structures, which interiors are "open planned". Interiors can be arranged and divided into rooms by using modular partition walls designed by authors.

  16. Advanced LMI based analysis and design for Acrobot walking

    NASA Astrophysics Data System (ADS)

    Anderle, Milan; Čelikovský, Sergej; Henrion, Didier; Zikmund, Jiří

    2010-08-01

    This article aims to further improve previously developed design for Acrobot walking based on partial exact feedback linearisation of order 3. Namely, such an exact system transformation leads to an almost linear system where error dynamics along trajectory to be tracked is a 4-dimensional linear time-varying system having three time-varying entries only, the remaining entries being either zero or one. In such a way, exponentially stable tracking can be obtained by quadratically stabilising a linear system with polytopic uncertainty. The current improvement is based on applying linear matrix inequalities (LMI) methods to solve this problem numerically. This careful analysis significantly improves previously known approaches. Numerical simulations of Acrobot walking based on the above-mentioned LMI design are demonstrated as well.

  17. Structural Design Methodology Based on Concepts of Uncertainty

    NASA Technical Reports Server (NTRS)

    Lin, K. Y.; Du, Jiaji; Rusk, David

    2000-01-01

    In this report, an approach to damage-tolerant aircraft structural design is proposed based on the concept of an equivalent "Level of Safety" that incorporates past service experience in the design of new structures. The discrete "Level of Safety" for a single inspection event is defined as the compliment of the probability that a single flaw size larger than the critical flaw size for residual strength of the structure exists, and that the flaw will not be detected. The cumulative "Level of Safety" for the entire structure is the product of the discrete "Level of Safety" values for each flaw of each damage type present at each location in the structure. Based on the definition of "Level of Safety", a design procedure was identified and demonstrated on a composite sandwich panel for various damage types, with results showing the sensitivity of the structural sizing parameters to the relative safety of the design. The "Level of Safety" approach has broad potential application to damage-tolerant aircraft structural design with uncertainty.

  18. Reliability-based design optimization using efficient global reliability analysis.

    SciTech Connect

    Bichon, Barron J.; Mahadevan, Sankaran; Eldred, Michael Scott

    2010-05-01

    Finding the optimal (lightest, least expensive, etc.) design for an engineered component that meets or exceeds a specified level of reliability is a problem of obvious interest across a wide spectrum of engineering fields. Various methods for this reliability-based design optimization problem have been proposed. Unfortunately, this problem is rarely solved in practice because, regardless of the method used, solving the problem is too expensive or the final solution is too inaccurate to ensure that the reliability constraint is actually satisfied. This is especially true for engineering applications involving expensive, implicit, and possibly nonlinear performance functions (such as large finite element models). The Efficient Global Reliability Analysis method was recently introduced to improve both the accuracy and efficiency of reliability analysis for this type of performance function. This paper explores how this new reliability analysis method can be used in a design optimization context to create a method of sufficient accuracy and efficiency to enable the use of reliability-based design optimization as a practical design tool.

  19. Hot spot management through design based metrology: measurement and filtering

    NASA Astrophysics Data System (ADS)

    Lee, Taehyeong; Yang, Hyunjo; Kim, Jungchan; Jung, Areum; Yoo, Gyun; Yim, Donggyu; Park, Sungki; Ishikawa, Akio; Yamamoto, Masahiro; Vikram, Abhishek

    2009-12-01

    Recently several Design Based Metrologies (DBMs) are introduced and being in use for wafer verification. The major applications of DBM are OPC accuracy improvement, DFM feed-back through Process Window Qualification (PWQ) and advanced process control. In general, however, the amount of output data from DBM is normally so large that it is very hard to handle the data for valuable feed-back. In case of PWQ, more than thousands of hot spots are detected on a single chip at the edge of process window. So, it takes much time and labor to review and analyze all the hot spots detected at PWQ. Design-related systematic defects, however, will be found repeatedly and if they can be classified into groups, it would be possible to save a lot of time for the analysis. We have demonstrated an EDA tool which can handle the large amount of output data from DBM by classifying pattern defects into groups. It can classify millions of patterns into less than thousands of pattern groups. It has been evaluated on the analysis of PWQ of metal layer in NAND Flash memory device and random contact hole patterns in a DRAM device. Also, verification was tuned to specific needs of the designer as well as defect analysis engineers by use of EDA tool's 'Pattern Matching Function'. The verification result was well within the required specification of the designer as well as the analysis engineer. The procedures of Hot Spot Management through Design Based Metrology are presented in detail.

  20. Advanced microgrid design and analysis for forward operating bases

    NASA Astrophysics Data System (ADS)

    Reasoner, Jonathan

    This thesis takes a holistic approach in creating an improved electric power generation system for a forward operating base (FOB) in the future through the design of an isolated microgrid. After an extensive literature search, this thesis found a need for drastic improvement of the FOB power system. A thorough design process analyzed FOB demand, researched demand side management improvements, evaluated various generation sources and energy storage options, and performed a HOMERRTM discrete optimization to determine the best microgrid design. Further sensitivity analysis was performed to see how changing parameters would affect the outcome. Lastly, this research also looks at some of the challenges which are associated with incorporating a design which relies heavily on inverter-based generation sources, and gives possible solutions to help make a renewable energy powered microgrid a reality. While this thesis uses a FOB as the case study, the process and discussion can be adapted to aide in the design of an off-grid small-scale power grid which utilizes high-penetration levels of renewable energy.

  1. Design and implementation of a project-based active/cooperative engineering design course for freshmen

    NASA Astrophysics Data System (ADS)

    Abdulaal, R. M.; Al-Bahi, A. M.; Soliman, A. Y.; Iskanderani, F. I.

    2011-08-01

    A project-based active/cooperative design course is planned, implemented, assessed and evaluated to achieve several desired engineering outcomes. The course allows freshman-level students to gain professional hands-on engineering design experience through an opportunity to practise teamwork, quality principles, communication skills, life-long learning, realistic constraints and awareness of current domestic and global challenges. Throughout successive design reports and in-class assignments, the students are required by the end of the semester to communicate, clearly and concisely, the details of their design both orally and in writing through a functional artefact/prototype, a design notebook, an A0 project poster and a final oral presentation. In addition to these direct assessment tools, several indirect measures are used to ensure triangulation. Assignments are based on customer expectations using a detailed checklist. This paper shows the direct and indirect assessment tools that indicated a high level of achievement of course learning outcomes and a high level of student satisfaction.

  2. Restoration as a science-based design problem

    NASA Astrophysics Data System (ADS)

    Pasternack, G.; Wheaton, J.

    2003-04-01

    Existing approaches for performing environmental restoration either involve problem diagnosis and assessment with little implementation or ad hoc construction with little forethought. Environmental assessment is an important aspect of stewardship that leads to the diagnosis and prioritization of problems requiring restoration. It should come before and inform restoration. Projects that are built ad hoc have been widely reported to fail due to a lack of recognition of key natural processes. By contrast, other creative human endeavors make extensive use of the science of design. Among other concepts, it is inherent in the design process to generate many alternatives, as open-ended problems always have multiple correct solutions. For environmental restoration, such alternatives can be created by integrating widely accepted concepts from hydrology, civil engineering, aquatic biology, riparian ecology, and geomorphology. Then the specifics of each alternative should be analyzed for their relative performance using predictive computer models and other analytical tools. A river restoration approach that makes use of a comprehensive science-based design process has been developed to address the specific problem of fish spawning habitat enhancement. The approach was used in summer 2001 and 2002. In the latter case, science-based design was used at multiple spatial scales. At the reach scale, designs aimed to elevate the bed and increase slopes over constructed riffles. At the sub-reach scale, designs incorporated a complex assemblage of geomorphic units including broad riffles (to encourage divergent flow and gravel deposition at high discharge), small pools (whose widths were constricted by bars to encourage convergent flow and scour at high discharge) and boulder complexes. After thorough analysis and evaluation, the best performing project was selected by a multidisciplinary design team according to habitat and geomorphic goals and then built. A long-term monitoring

  3. Game Theory and Risk-Based Levee System Design

    NASA Astrophysics Data System (ADS)

    Hui, R.; Lund, J. R.; Madani, K.

    2014-12-01

    Risk-based analysis has been developed for optimal levee design for economic efficiency. Along many rivers, two levees on opposite riverbanks act as a simple levee system. Being rational and self-interested, land owners on each river bank would tend to independently optimize their levees with risk-based analysis, resulting in a Pareto-inefficient levee system design from the social planner's perspective. Game theory is applied in this study to analyze decision making process in a simple levee system in which the land owners on each river bank develop their design strategies using risk-based economic optimization. For each land owner, the annual expected total cost includes expected annual damage cost and annualized construction cost. The non-cooperative Nash equilibrium is identified and compared to the social planner's optimal distribution of flood risk and damage cost throughout the system which results in the minimum total flood cost for the system. The social planner's optimal solution is not feasible without appropriate level of compensation for the transferred flood risk to guarantee and improve conditions for all parties. Therefore, cooperative game theory is then employed to develop an economically optimal design that can be implemented in practice. By examining the game in the reversible and irreversible decision making modes, the cost of decision making myopia is calculated to underline the significance of considering the externalities and evolution path of dynamic water resource problems for optimal decision making.

  4. SP-100 power system conceptual design for lunar base applications

    NASA Technical Reports Server (NTRS)

    Mason, Lee S.; Bloomfield, Harvey S.; Hainley, Donald C.

    1989-01-01

    A conceptual design is presented for a nuclear power system utilizing an SP-100 reactor and multiple Stirling cycle engines for operation on the lunar surface. Based on the results of this study, it was concluded that this power plant could be a viable option for an evolutionary lunar base. The design concept consists of a 2500 kWt (kilowatt thermal) SP-100 reactor coupled to eight free-piston Stirling engines. Two of the engines are held in reserve to provide conversion system redundancy. The remaining engines operate at 91.7 percent of their rated capacity of 150 kWe. The design power level for this system is 825 kWe. Each engine has a pumped heat-rejection loop connected to a heat pipe radiator. Power system performance, sizing, layout configurations, shielding options, and transmission line characteristics are described. System components and integration options are compared for safety, high performance, low mass, and ease of assembly. The power plant was integrated with a proposed human lunar base concept to ensure mission compatibility. This study should be considered a preliminary investigation; further studies are planned to investigate the effect of different technologies on this baseline design.

  5. Reliability-based analysis and design optimization for durability

    NASA Astrophysics Data System (ADS)

    Choi, Kyung K.; Youn, Byeng D.; Tang, Jun; Hardee, Edward

    2005-05-01

    In the Army mechanical fatigue subject to external and inertia transient loads in the service life of mechanical systems often leads to a structural failure due to accumulated damage. Structural durability analysis that predicts the fatigue life of mechanical components subject to dynamic stresses and strains is a compute intensive multidisciplinary simulation process, since it requires the integration of several computer-aided engineering tools and considerable data communication and computation. Uncertainties in geometric dimensions due to manufacturing tolerances cause the indeterministic nature of the fatigue life of a mechanical component. Due to the fact that uncertainty propagation to structural fatigue under transient dynamic loading is not only numerically complicated but also extremely computationally expensive, it is a challenging task to develop a structural durability-based design optimization process and reliability analysis to ascertain whether the optimal design is reliable. The objective of this paper is the demonstration of an integrated CAD-based computer-aided engineering process to effectively carry out design optimization for structural durability, yielding a durable and cost-effectively manufacturable product. This paper shows preliminary results of reliability-based durability design optimization for the Army Stryker A-Arm.

  6. Meta-case based realization of design rationale management systems

    SciTech Connect

    Paul, G.

    1996-12-31

    System design is an iterative, creative, and cooperative process where informal ideas are transformed into a detailed definition of how a system can be implemented. Design rationale aims at capturing and preserving the why underlying the what, the argument behind the artifact in the design process. Recording deliberations of the design process therefore promises benefits for the overall system engineering life cycle. Providing adequate computer support for design rationale is an interesting issue and a real need for effective application. A design rationale management system (DRMS) supports the capturing, storing and retrieval of interaction rationale in a shared corporate knowledge base and allows organizational learning through long-term and inter-project reuse. The intent of meta-CASE systems is to capture the specification of a required CASE tool and then generate the tool for actual production from the specification. In this paper we identify the requirements for a DRMS and investigate the applicability of meta-CASE tools for the implementation of DRMS`s. Furthermore we describe the experiences gained in the development of two DRMS`s adopting the meta CASE tools MaestroII GED/TCI and Hardy.

  7. Design optimization for a space based, reusable orbit transfer vehicle

    NASA Technical Reports Server (NTRS)

    Redd, L.

    1985-01-01

    Future NASA and DOD missions will benefit from high performance, reusable orbit transfer vehicles. With the advent of a space station, advanced engine technology, and various new vehicle concepts, reusable orbit transfer vehicles that provide significant economic benefits and mission capability improvements will be realized. Engine and vehicle design criteria previously have lacked definition with regard to issues such as space basing and servicing, man-rating and reliability, performance, mission flexibility, and life cycle cost for a reusable vehicle. The design study described here has resulted in the definition of a reusable orbit transfer vehicle concept and subsequent recommendations for the design criteria of an advanced LO2/LH2 engine. These design criteria include number of engines per vehicle, nozzle design, etc. The major characteristics of the vehicle preliminary design include low lift to drag aerocapture capability, a main propulsion system failure criteria of fail operational/fail safe, and either two main engines with a high performance attitude control system for back-up or three main engines with which to meet this failure criteria. In addition, a maintenance approach has been established for the advanced vehicle concept.

  8. Robustness-Based Design Optimization Under Data Uncertainty

    NASA Technical Reports Server (NTRS)

    Zaman, Kais; McDonald, Mark; Mahadevan, Sankaran; Green, Lawrence

    2010-01-01

    This paper proposes formulations and algorithms for design optimization under both aleatory (i.e., natural or physical variability) and epistemic uncertainty (i.e., imprecise probabilistic information), from the perspective of system robustness. The proposed formulations deal with epistemic uncertainty arising from both sparse and interval data without any assumption about the probability distributions of the random variables. A decoupled approach is proposed in this paper to un-nest the robustness-based design from the analysis of non-design epistemic variables to achieve computational efficiency. The proposed methods are illustrated for the upper stage design problem of a two-stage-to-orbit (TSTO) vehicle, where the information on the random design inputs are only available as sparse point and/or interval data. As collecting more data reduces uncertainty but increases cost, the effect of sample size on the optimality and robustness of the solution is also studied. A method is developed to determine the optimal sample size for sparse point data that leads to the solutions of the design problem that are least sensitive to variations in the input random variables.

  9. Structure based design of 11β-HSD1 inhibitors.

    PubMed

    Singh, Suresh; Tice, Colin

    2010-11-01

    Controlling elevated tissue-specific levels of cortisol may provide a novel therapeutic approach for treating metabolic syndrome. This concept has spurred large scale medicinal chemistry efforts in the pharmaceutical industry for the design of 11β-HSD1 inhibitors. High resolution X-ray crystal structures of inhibitors in complex with the enzyme have facilitated the structure-based design of diverse classes of molecules. A summary of binding modes, trends in structure-activity relationships, and the pharmacodynamic data of inhibitors from each class is presented.

  10. Structural design methodologies for ceramic-based material systems

    NASA Technical Reports Server (NTRS)

    Duffy, Stephen F.; Chulya, Abhisak; Gyekenyesi, John P.

    1991-01-01

    One of the primary pacing items for realizing the full potential of ceramic-based structural components is the development of new design methods and protocols. The focus here is on low temperature, fast-fracture analysis of monolithic, whisker-toughened, laminated, and woven ceramic composites. A number of design models and criteria are highlighted. Public domain computer algorithms, which aid engineers in predicting the fast-fracture reliability of structural components, are mentioned. Emphasis is not placed on evaluating the models, but instead is focused on the issues relevant to the current state of the art.

  11. Molecular rectifiers: a new design based on asymmetric anchoring moieties.

    PubMed

    Van Dyck, Colin; Ratner, Mark A

    2015-03-11

    The quest for a molecular rectifier is among the major challenges of molecular electronics. We introduce three simple rules to design an efficient rectifying molecule and demonstrate its functioning at the theoretical level, relying on the NEGF-DFT technique. The design rules notably require both the introduction of asymmetric anchoring moieties and a decoupling bridge. They lead to a new rectification mechanism based on the compression and control of the HOMO/LUMO gap by the electrode Fermi levels, arising from a pinning effect. Significant rectification ratios up to 2 orders of magnitude are theoretically predicted as the mechanism opposes resonant to nonresonant tunneling.

  12. A design approach for systems based on magnetic pulse compression.

    PubMed

    Kumar, D Durga Praveen; Mitra, S; Senthil, K; Sharma, D K; Rajan, Rehim N; Sharma, Archana; Nagesh, K V; Chakravarthy, D P

    2008-04-01

    A design approach giving the optimum number of stages in a magnetic pulse compression circuit and gain per stage is given. The limitation on the maximum gain per stage is discussed. The total system volume minimization is done by considering the energy storage capacitor volume and magnetic core volume at each stage. At the end of this paper, the design of a magnetic pulse compression based linear induction accelerator of 200 kV, 5 kA, and 100 ns with a repetition rate of 100 Hz is discussed with its experimental results.

  13. Disturbance Rejection Based Test Rocket Control System Design and Validation

    NASA Astrophysics Data System (ADS)

    Yang, H.; Zhang, S.; Li, T.; Zhang, Y.

    2015-09-01

    This paper presents a novel design and validation for the three-channel attitude controller of a STT test rocket based on the extended state observer approach. The uniform second order integral-chain state space model is firstly established for the control variable of the angle of attack, angle of sideslip and roll angle. Combined with the pole placement, the extended state observer is applied to the disturbance rejection design of the attitude controller. Through numerical and hardware-in-the-loop simulation with uncertainties considered, the effectiveness and robustness of the controller are illustrated and verified. Finally, the performance of the controller is validated by flight-test with satisfactory results.

  14. Design of the storage location based on the ABC analyses

    NASA Astrophysics Data System (ADS)

    Jemelka, Milan; Chramcov, Bronislav; Kříž, Pavel

    2016-06-01

    The paper focuses on process efficiency and saving storage costs. Maintaining inventory through putaway strategy takes personnel time and costs money. The aim is to control inventory in the best way. The ABC classification based on Villefredo Pareto theory is used for a design of warehouse layout. New design of storage location reduces the distance of fork-lifters, total costs and it increases inventory process efficiency. The suggested solutions and evaluation of achieved results are described in detail. Proposed solutions were realized in real warehouse operation.

  15. INFORMATION DISPLAY: CONSIDERATIONS FOR DESIGNING COMPUTER-BASED DISPLAY SYSTEMS.

    SciTech Connect

    O'HARA,J.M.; PIRUS,D.; BELTRATCCHI,L.

    2004-09-19

    This paper discussed the presentation of information in computer-based control rooms. Issues associated with the typical displays currently in use are discussed. It is concluded that these displays should be augmented with new displays designed to better meet the information needs of plant personnel and to minimize the need for interface management tasks (the activities personnel have to do to access and organize the information they need). Several approaches to information design are discussed, specifically addressing: (1) monitoring, detection, and situation assessment; (2) routine task performance; and (3) teamwork, crew coordination, collaborative work.

  16. Design Principles, Implementation And Evaluation For Inquiry-Based Astronomy:

    NASA Astrophysics Data System (ADS)

    Fitzgerald, Michael

    2015-09-01

    This thesis is situated in the context of an Australian high school level astronomy intervention project which aimed to enable students to undertake real science with professional grade 2-metre class telescopes. The thesis explores the context and background within which the project was situated and the main blocking factors preventing successful implementation culminating in an outline of the education design used in, and the evaluation of, the project. This work has illustrated that with careful design and sufficient teacher training and support, inquiry-based astronomy can feasibly be undertaken in the high-school classroom.

  17. Preliminary Polar Sea Trials of Nereid-UI: A Remotely Operated Underwater Vehicle for Oceanographic Access Under Ice

    NASA Astrophysics Data System (ADS)

    Whitcomb, L. L.; Jakuba, M.; German, C. R.; Bowen, A.; Yoerger, D.; Kinsey, J. C.; Mayer, L.; McFarland, C.; Suman, S.; Bailey, J.; Judge, C.; Elliott, S.; Gomez-Ibanez, D.; Taylor, C. L.; Machado, C.; Howland, J. C.; Kaiser, C.; Heintz, M.; Pontbriand, C.; O'Hara, L.; McDonald, G.; Boetius, A.

    2014-12-01

    We report the development and deployment of a remotely-controlled underwater robotic vehicle capable of being teleoperated under ice under real-time human supervision. The Nereid Under-Ice (Nereid-UI or NUI) vehicle enables exploration and detailed examination of biological and physical environments including the ice-ocean interface in marginal ice zones, in the water column of ice-covered seas, at glacial ice-tongues, and ice-shelf margins, delivering realtime high definition video in addition to survey data from on board acoustic, optical, chemical, and biological sensors. The vehicle employs a novel lightweight fiber-optic tether that will enable it to be deployed from a ship to attain standoff distances of up to 20 km from an ice-edge boundary. We conducted NUI's first under-ice deployments during the July 2014 F/V Polarstern PS86 expedition at 86° N 6 W° in the Arctic Ocean - near the Aurora hydrothermal vent site on the Gakkel Ridge approximately 200 km NE of Greenland. We conducted 4 dives to evaluate and develop NUI's overall functioning and its individual engineered subsystems. On each dive, dead-reckoning (Ice-locked Doppler sonar and north-seeking gyrocompass) complemented by acoustic ranging provided navigation, supporting closed-loop control of heading, depth, and XY position relative to the ice. Science operations included multibeam transects of under-ice topography, precision vertical profiles for the bio-sensor suite and IR/radiance sensor suite, IR/radiance/multibeam transects at constant depth interlaced with vertical profiles and upward-looking digital still-camera surveys of the ice, including areas rich with algal material. The fiber-optic tether remained intact throughout most of all 4 dives. Consistent with the NUI concept of operations, in 3 of 4 dives the fiber-optic tether eventually failed, and the vehicle was then commanded acoustically in a series of short-duration maneuvers to return to Polarstern for recovery. These preliminary

  18. Place-Based Design: An Instructional Design Theory for Supporting Community-Based Inquiry and Design Projects

    ERIC Educational Resources Information Center

    Mathews, James M.

    2013-01-01

    Place-based education has been forwarded as a pedagogical approach that has the potential to contextualize learning, increase student engagement, and strengthen the relationship between schools and the broader community. Despite this promise, however, many teachers struggle to develop learning experiences that incorporate the key components of…

  19. Advanced software development workstation. Knowledge base design: Design of knowledge base for flight planning application

    NASA Technical Reports Server (NTRS)

    Izygon, Michel E.

    1992-01-01

    The development process of the knowledge base for the generation of Test Libraries for Mission Operations Computer (MOC) Command Support focused on a series of information gathering interviews. These knowledge capture sessions are supporting the development of a prototype for evaluating the capabilities of INTUIT on such an application. the prototype includes functions related to POCC (Payload Operation Control Center) processing. It prompts the end-users for input through a series of panels and then generates the Meds associated with the initialization and the update of hazardous command tables for a POCC Processing TLIB.

  20. Small Area Array-Based LED Luminaire Design

    SciTech Connect

    Thomas Yuan

    2008-01-09

    This report contains a summary of technical achievements during a three-year project to demonstrate high efficiency LED luminaire designs based on small area array-based gallium nitride diodes. Novel GaN-based LED array designs are described, specifically addressing the thermal, optical, electrical and mechanical requirements for the incorporation of such arrays into viable solid-state LED luminaires. This work resulted in the demonstration of an integrated luminaire prototype of 1000 lumens cool white light output with reflector shaped beams and efficacy of 89.4 lm/W at CCT of 6000oK and CRI of 73; and performance of 903 lumens warm white light output with reflector shaped beams and efficacy of 63.0 lm/W at CCT of 2800oK and CRI of 82. In addition, up to 1275 lumens cool white light output at 114.2 lm/W and 1156 lumens warm white light output at 76.5 lm/W were achieved if the reflector was not used. The success to integrate small area array-based LED designs and address thermal, optical, electrical and mechanical requirements was clearly achieved in these luminaire prototypes with outstanding performance and high efficiency.