22 CFR 120.11 - Public domain.

Code of Federal Regulations, 2014 CFR

2014-04-01

... libraries open to the public or from which the public can obtain documents; (5) Through patents available at... fundamental research in science and engineering at accredited institutions of higher learning in the U.S.... Fundamental research is defined to mean basic and applied research in science and engineering where the...

22 CFR 120.11 - Public domain.

Code of Federal Regulations, 2011 CFR

2011-04-01

... libraries open to the public or from which the public can obtain documents; (5) Through patents available at... fundamental research in science and engineering at accredited institutions of higher learning in the U.S.... Fundamental research is defined to mean basic and applied research in science and engineering where the...

22 CFR 120.11 - Public domain.

Code of Federal Regulations, 2013 CFR

2013-04-01

... libraries open to the public or from which the public can obtain documents; (5) Through patents available at... fundamental research in science and engineering at accredited institutions of higher learning in the U.S.... Fundamental research is defined to mean basic and applied research in science and engineering where the...

Analysis of liquid-propellant rocket engines designed by F. A. Tsander

NASA Technical Reports Server (NTRS)

Dushkin, L. S.; Moshkin, Y. K.

1977-01-01

The development of the oxygen-gasoline OR-2 engines and the oxygen-alcohol GIRD-10 rocket engine is described. A result of Tsander's rocket research was an engineering method for propellant calculation of oxygen-propellant rocket engines that determined the basic parameters of the engine and the structural elements.

Basic Scientific and Engineering Research at U.S. Universities. AAU Data & Policy Brief. No. 1

ERIC Educational Resources Information Center

Association of American Universities, 2015

2015-01-01

"Discovery," wrote William Press in a 2013 article in "Science," "leads to technology and invention, which lead to new products, jobs, and industries." Basic, curiosity-driven research continually expands the boundaries of knowledge across fields, providing insights that enrich lives. Such research helps drive the…

Department of Defense Basic Research Program.

DTIC Science & Technology

1980-08-01

Oamond Laboratories, ERADCOM. Foreword This report has been prepared by the Research Office, ffice of the Deputy Under Secretary of Defense for... Research and Engineering ( Research and Advanced Technology~jlt is the first report ever written for the express purpose of describing the Department of...Defense basic research program. The report is part of an overall effort to improve communications with the national research community by increasing the

Initial Comparison of Single Cylinder Stirling Engine Computer Model Predictions with Test Results

NASA Technical Reports Server (NTRS)

Tew, R. C., Jr.; Thieme, L. G.; Miao, D.

1979-01-01

A Stirling engine digital computer model developed at NASA Lewis Research Center was configured to predict the performance of the GPU-3 single-cylinder rhombic drive engine. Revisions to the basic equations and assumptions are discussed. Model predictions with the early results of the Lewis Research Center GPU-3 tests are compared.

POLLUTION PREVENTION RESEARCH ONGOING - EPA'S RISK REDUCTION ENGINEERING LABORATORY

EPA Science Inventory

The mission of the Risk Reduction Engineering Laboratory is to advance the understanding, development and application of engineering solutions for the prevention or reduction of risks from environmental contamination. This mission is accomplished through basic and applied researc...

Basic Energy Sciences FY 2011 Research Summaries

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This report provides a collection of research abstracts for more than 1,300 research projects funded by the Office of Basic Energy Sciences (BES) in Fiscal Year 2011 at some 180 institutions across the U.S. This volume is organized along the three BES divisions: Materials Sciences and Engineering; Chemical Sciences, Geosciences, and Biosciences; and Scientific User Facilities.

Basic Energy Sciences FY 2012 Research Summaries

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This report provides a collection of research abstracts and highlights for more than 1,400 research projects funded by the Office of Basic Energy Sciences (BES) in Fiscal Year 2012 at some 180 institutions across the U.S. This volume is organized along the three BES Divisions: Materials Sciences and Engineering; Chemical Sciences, Geosciences, and Biosciences; and Scientific User Facilities.

Basic Energy Sciences FY 2014 Research Summaries

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This report provides a collection of research abstracts and highlights for more than 1,200 research projects funded by the Office of Basic Energy Sciences (BES) in Fiscal Year 2014 at some 200 institutions across the U.S. This volume is organized along the three BES Divisions: Materials Sciences and Engineering; Chemical Sciences, Geosciences, and Biosciences; and Scientific User Facilities.

Conceptual design studies and experiments related to cavity exhaust systems for nuclear light bulb configurations

NASA Technical Reports Server (NTRS)

Kendall, J. S.; Stoeffler, R. C.

1972-01-01

Investigations of various phases of gaseous nuclear rocket technology have been conducted. The principal research efforts have recently been directed toward the closed-cycle, vortex-stabilized nuclear light bulb engine and toward a small-scale fissioning uranium plasma experiment that could be conducted in the Los Alamos Scientific Laboratory's Nuclear Furnace. The engine concept is based on the transfer of energy by thermal radiation from gaseous fissioning uranium, through a transparent wall, to hydrogen propellant. The reference engine configuration is comprised of seven unit cavities, each having its own fuel transparent wall and propellant duct. The basic design of the engine is described. Subsequent studies performed to supplement and investigate the basic design are reported. Summaries of other nuclear light bulb research programs are included.

ICASE semiannual report, April 1 - September 30, 1989

NASA Technical Reports Server (NTRS)

1990-01-01

The Institute conducts unclassified basic research in applied mathematics, numerical analysis, and computer science in order to extend and improve problem-solving capabilities in science and engineering, particularly in aeronautics and space. The major categories of the current Institute for Computer Applications in Science and Engineering (ICASE) research program are: (1) numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; (2) control and parameter identification problems, with emphasis on effective numerical methods; (3) computational problems in engineering and the physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and (4) computer systems and software, especially vector and parallel computers. ICASE reports are considered to be primarily preprints of manuscripts that have been submitted to appropriate research journals or that are to appear in conference proceedings.

PhysioNet: physiologic signals, time series and related open source software for basic, clinical, and applied research.

PubMed

Moody, George B; Mark, Roger G; Goldberger, Ary L

2011-01-01

PhysioNet provides free web access to over 50 collections of recorded physiologic signals and time series, and related open-source software, in support of basic, clinical, and applied research in medicine, physiology, public health, biomedical engineering and computing, and medical instrument design and evaluation. Its three components (PhysioBank, the archive of signals; PhysioToolkit, the software library; and PhysioNetWorks, the virtual laboratory for collaborative development of future PhysioBank data collections and PhysioToolkit software components) connect researchers and students who need physiologic signals and relevant software with researchers who have data and software to share. PhysioNet's annual open engineering challenges stimulate rapid progress on unsolved or poorly solved questions of basic or clinical interest, by focusing attention on achievable solutions that can be evaluated and compared objectively using freely available reference data.

Software engineering from a Langley perspective

NASA Technical Reports Server (NTRS)

Voigt, Susan

1994-01-01

A brief introduction to software engineering is presented. The talk is divided into four sections beginning with the question 'What is software engineering', followed by a brief history of the progression of software engineering at the Langley Research Center in the context of an expanding computing environment. Several basic concepts and terms are introduced, including software development life cycles and maturity levels. Finally, comments are offered on what software engineering means for the Langley Research Center and where to find more information on the subject.

Development of Servo Motor Trainer for Basic Control System in Laboratory of Electrical Engineering Control System Faculty of Engineering Universitas Negeri Surabaya

NASA Astrophysics Data System (ADS)

Endryansyah; Wanarti Rusimamto, Puput; Ridianto, Adam; Sugiarto, Hariyadi

2018-04-01

In the Department of Electrical Engineering FT Unesa, there are 3 majors: S1 Electrical Engineering Education, S1 Electrical Engineering, and D3 Electrical Engineering. Courses the Basic System Settings go to in the curriculum of the three programs. Team lecturer college of basic system settings seek learning innovation, focused on the development of trainer to student practicum at the laboratory of systems control. Trainer developed is a servo motor along with the lab module that contains a wide variety of theories about the servo motor and guide the practicum. This research type is development research using methods Research & development (R & D). In which the steps are applied in this study is as follows: pay attention to the potential and existing problems, gather information and study the literature, design the product, validate the design, revise the design, a limited trial. The results of the validation of learning device in the form of modules and trainer obtained as follows: score validation of learning device is 3,64; score validation lab module Servo Motor is 3,47; and questionnaire responses of students is 3,73. The result of the whole validation value is located in the interval >of 3.25 s/d 4 with the category of “Very Valid”, so it can be concluded that all instruments have a level of validity “Very Valid” and worthy of use for further learning.

The Value of Competitive Contracting

DTIC Science & Technology

2014-09-01

Research & Engineering) BBP Better Buying Power BOA basic ordering agreement BPA basic purchase agreement CAE Component Acquisition Executive CDSA...competitive procedures for the following contract actions:” a. Contract and purchase orders b. Orders and calls under part 13 Basic Purchase Agreement ( BPA ...Basic Ordering Agreement (BOA) c. Government wide acquisition contracts and IDIQ contracts d. BPAs and BPA calls under Federal Supply Schedules

Young Investigator Research Program (YIP)

NASA Astrophysics Data System (ADS)

Robinson, Ellen

The Air Force YIP supports scientists and engineers who have received Ph.D. or equivalent degrees in the last five years and show exceptional ability and promise for conducting basic research. The objective of this program is to foster creative basic research in science and engineering; enhance early career development of outstanding young investigators; and increase opportunities for the young investigator to recognize the Air Force mission and related challenges in science and engineering. Individual awards will be made to U.S. institutions of higher education, industrial laboratories or non-profit research organizations where the principal investigator is a U.S. citizen, national or permanent resident; employed on a full-time basis and hold a regular position. Researchers working at the Federally Funded Research and Development Centers and DoD Laboratories will not be considered for the YIP competition. Each award will be funded at the 120K level for three years. Exceptional proposals will be considered individually for higher funding levels and longer duration. http://www.wpafb.af.mil/Welcome/Fact-Sheets/Display/Article/842100#anchor2 I will brief Air Force Office Of Scientific Research Young Investigator Research Program.

Tissue engineering and regenerative medicine in applied research: a year in review of 2014.

PubMed

Lin, Xunxun; Huang, Jia; Shi, Yuan; Liu, Wei

2015-04-01

Tissue engineering and regenerative medicine (TERM) remains to be one of the fastest growing fields, which covers a wide scope of topics of both basic and applied biological researches. This overview article summarized the advancements in applied researches of TERM area, including stem cell-mediated tissue regeneration, material science, and TERM clinical trial. These achievements demonstrated the great potential of clinical regenerative therapy of tissue/organ disease or defect through stem cells and tissue engineering approaches.

Applied Problems and Use of Technology in an Aligned Way in Basic Courses in Probability and Statistics for Engineering Students--A Way to Enhance Understanding and Increase Motivation

ERIC Educational Resources Information Center

Zetterqvist, Lena

2017-01-01

Researchers and teachers often recommend motivating exercises and use of mathematics or statistics software for the teaching of basic courses in probability and statistics. Our courses are given to large groups of engineering students at Lund Institute of Technology. We found that the mere existence of real-life data and technology in a course…

Teaching Reinforcement of Stochastic Behavior Using Monte Carlo Simulation.

ERIC Educational Resources Information Center

Fox, William P.; And Others

1996-01-01

Explains a proposed block of instruction that would give students in industrial engineering, operations research, systems engineering, and applied mathematics the basic understanding required to begin more advanced courses in simulation theory or applications. (DDR)

Diminishing Funding and Rising Expectations: Trends and Challenges for Public Research Universities. A Companion to Science and Engineering Indicators 2012. NSB-12-45

ERIC Educational Resources Information Center

National Science Foundation, 2012

2012-01-01

Research universities, both public and private alike, are the leading producers of science and engineering (S&E) bachelor's, master's, and doctoral degrees. They are contributors to economic development at the local, state, and national levels, performing over half of the Nation's total basic research in 2009, and they educate and train our…

Illuminating Engineering Research Institute Annual Report 1967. A Review of Project Activities and a Roundup of IERI Research Interests.

ERIC Educational Resources Information Center

Illuminating Engineering Research Inst., New York, NY.

Presented in this report are the Illuminating Engineering Research Institute's fundamental scientific concepts in a new frame of realism while relating them to an up-to-date accounting of the search for new basic knowledge. In addition to being an annual accounting, it is also intended to provide orientation. Its presented in dramatic and…

Technicians Manufacture a Nozzle for the Kiwi B-1-B Engine

NASA Image and Video Library

1964-05-21

Technicians manufacture a nozzle for the Kiwi B-1-B nuclear rocket engine in the Fabrication Shop’s vacuum oven at the National Aeronautics and Space Administration (NASA) Lewis Research Center. The Nuclear Engine for Rocket Vehicle Applications (NERVA) was a joint NASA and Atomic Energy Commission (AEC) endeavor to develop a nuclear-powered rocket for both long-range missions to Mars and as a possible upper-stage for the Apollo Program. The early portion of the program consisted of basic reactor and fuel system research. This was followed by a series of Kiwi reactors built to test basic nuclear rocket principles in a non-flying nuclear engine. The next phase, NERVA, would create an entire flyable engine. The final phase of the program, called Reactor-In-Flight-Test, would be an actual launch test. The AEC was responsible for designing the nuclear reactor and overall engine. NASA Lewis was responsible for developing the liquid-hydrogen fuel system. The turbopump, which pumped the fuels from the storage tanks to the engine, was the primary tool for restarting the engine. The NERVA had to be able to restart in space on its own using a safe preprogrammed startup system. Lewis researchers endeavored to design and test this system. This non-nuclear Kiwi engine, seen here, was being prepared for tests at Lewis’ High Energy Rocket Engine Research Facility (B-1) located at Plum Brook Station. The tests were designed to start an unfueled Kiwi B-1-B reactor and its Aerojet Mark IX turbopump without any external power.

Doctoral and Postdoctoral Education in Science and Engineering: Europe in the International Competition

ERIC Educational Resources Information Center

MOGUEROU, PHILIPPE

2005-01-01

In this article, we discuss the recent evolutions of science and engineering doctoral and postdoctoral education in Europe. Indeed, Ph.Ds are crucial to the conduct of research and innovation in the national innovation systems, as they provide a large amount of input into creating the competitive advantage, notably through basic research. First,…

The Center for Advanced Systems and Engineering (CASE)

DTIC Science & Technology

2012-01-01

targets from multiple sensors. Qinru Qiu, State University of New York at Binghamton – A Neuromorphic Approach for Intelligent Text Recognition...Rogers, SUNYIT, Basic Research, Development and Emulation of Derived Models of Neuromorphic Brain Processes to Investigate the Computational Architecture...Issues They Present Work pertaining to the basic research, development and emulation of derived models of Neuromorphic brain processes to

32 CFR 272.4 - Policy.

Code of Federal Regulations, 2011 CFR

2011-07-01

... training of scientists and engineers critical to meeting future needs of the Nation's defense workforce. (b... industrial research laboratories. (c) The DoD Components' conduct and support of basic research shall be...

32 CFR 272.4 - Policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... training of scientists and engineers critical to meeting future needs of the Nation's defense workforce. (b... industrial research laboratories. (c) The DoD Components' conduct and support of basic research shall be...

Standardized Radiation Shield Design Methods: 2005 HZETRN

NASA Technical Reports Server (NTRS)

Wilson, John W.; Tripathi, Ram K.; Badavi, Francis F.; Cucinotta, Francis A.

2006-01-01

Research committed by the Langley Research Center through 1995 resulting in the HZETRN code provides the current basis for shield design methods according to NASA STD-3000 (2005). With this new prominence, the database, basic numerical procedures, and algorithms are being re-examined with new methods of verification and validation being implemented to capture a well defined algorithm for engineering design processes to be used in this early development phase of the Bush initiative. This process provides the methodology to transform the 1995 HZETRN research code into the 2005 HZETRN engineering code to be available for these early design processes. In this paper, we will review the basic derivations including new corrections to the codes to insure improved numerical stability and provide benchmarks for code verification.

Conflict Management in Collaborative Engineering Design: Basic Research in Fundamental Theory, Modeling Framework, and Computer Support for Collaborative Engineering Activities

DTIC Science & Technology

2002-01-01

behaviors are influenced by social interactions, and to how modern IT sys- tems should be designed to support these group technical activities. The...engineering disciplines to behavior, decision, psychology, organization, and the social sciences. “Conflict manage- ment activity in collaborative...Researchers instead began to search for an entirely new paradigm, starting from a theory in social science, to construct a conceptual framework to describe

Priming the Innovation Pump: America Needs More Scientists, Engineers, and Basic Research

DTIC Science & Technology

2011-01-01

students through its Science, Mathematics, and Research for Transforma- tion ( SMART ) program. SMART funds U.S. S&E students’ education costs in exchange...slide 5). Through its Engineers in the Classroom program, LM is building school partnerships to create a pipeline of future S&E employees. From high... Classroom need to expand in size and numbers, because it can take 22–25 years to grow an experienced engineer from entry-level talent. Meanwhile, the

Water Resources Research October 1, 1979 - September 30, 1980: Summary statements of research activities by the Water Resources Division

USGS Publications Warehouse

,

1981-01-01

Research in the WRD had its beginnings in the late 1950's when the "core research" line item was added to the Congressional budget. Since this time the Federal program has grown from a "basic sciences" program to one that includes a broad spectrum of basic and applied scientific investigations. Water resources research in WRD includes the study of water in all its phases and uses the basic sciences of mathematics, chemistry, physics, biology, geology and engineering to gain a fundamental understanding of the processes that affect the movement of water and its chemical constituents through hydrologic systems. The basic knowledge and methodologies derived from water resources research are applicable not only to the solution of current problems associated with the Nation's water resources, but also to anticipated hydrologic issues.

Summaries of FY 1979 research in the chemical sciences

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1980-05-01

The purpose of this report is to help those interested in research supported by the Department of Energy's Division of Chemical Sciences, which is one of six Divisions of the Office of Basic Energy Sciences in the Office of Energy Research. Chemists, physicists, chemical engineers and others who are considering the possibility of proposing research for support by this Division wll find the booklet useful for gauging the scope of the program in basic research, and the relationship of their interests to the overall program. These smmaries are intended to provide a rapid means for becoming acquainted with the Chemicalmore » Sciences program for members of the scientific and technological public, and interested persons in the Legislative and Executive Branches of the Government, in order to indicate the areas of research supported by the Division and energy technologies which may be advanced by use of basic knowledge discovered in this program. Scientific excellence is a major criterion applied in the selection of research supported by Chemical Sciences. Another important consideration is the identifying of chemical, physical and chemical engineering subdisciplines which are advancing in ways which produce new information related to energy, needed data, or new ideas.« less

FY 2014 LDRD Annual Report Project Summaries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tomchak, Dena

The FY 2014 Laboratory Directed Research and Development (LDRD) Annual Report is a compendium of the diverse research performed to develop and ensure the INL's technical capabilities can support future DOE missions and national research priorities. LDRD is essential to INL - it provides a means for the laboratory to pursue novel scientific and engineering research in areas that are deemed too basic or risky for programmatic investments. This research enahnces technical capabilities at the laboratory, providing scientific and engineering staff with opportunities for skill building and partnership development.

15 CFR 1180.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-01-01

... dissemination. Scientific, technical and engineering information means— (1) Basic and applied research that.... Federally funded refers to STEI which results from federal research and development activities funded in..., cooperative research partners, joint venture partners, or under any similar arrangement involving federal...

Mechanisms, applications, and perspectives of antiviral RNA silencing in plants

PubMed Central

Garcia-Ruiz, Hernan; Ruiz, Mayra Teresa Garcia; Peralta, Sergio Manuel Gabriel; Gabriel, Cristina Betzabeth Miravel; El-Mounadi, Kautar

2017-01-01

Viral diseases of plants cause important economic losses due to reduction in crop quality and quantity to the point of threatening food security in some countries. Given the reduced availability of natural sources, genetic resistance to viruses has been successfully engineered for some plant-virus combinations. A sound understanding of the basic mechanisms governing plant-virus interactions, including antiviral RNA silencing, is the foundation to design better management strategies and biotechnological approaches to engineer and implement antiviral resistance in plants. In this review, we present current molecular models to explain antiviral RNA silencing and its application in basic plant research, biotechnology and genetic engineering. PMID:28890589

University Research Consortium annual review meeting program

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-07-01

This brochure presents the program for the first annual review meeting of the University Research Consortium (URC) of the Idaho National Engineering Laboratory (INEL). INEL is a multiprogram laboratory with a distinctive role in applied engineering. It also conducts basic science research and development, and complex facility operations. The URC program consists of a portfolio of research projects funded by INEL and conducted at universities in the United States. In this program, summaries and participant lists for each project are presented as received from the principal investigators.

Laboratory Directed Research and Development FY-10 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dena Tomchak

2011-03-01

The FY 2010 Laboratory Directed Research and Development (LDRD) Annual Report is a compendium of the diverse research performed to develop and ensure the INL's technical capabilities can support the future DOE missions and national research priorities. LDRD is essential to the INL -- it provides a means for the laboratory to pursue novel scientific and engineering research in areas that are deemed too basic or risky for programmatic investments. This research enhances technical capabilities at the laboratory, providing scientific and engineering staff with opportunities for skill building and partnership development.

Constructing an Evidence-Base for Future CALL Design with "Engineering Power": The Need for More Basic Research and Instrumental Replication

ERIC Educational Resources Information Center

Handley, Zöe

2014-01-01

This paper argues that the goal of Computer-Assisted Language Learning (CALL) research should be to construct a reliable evidence-base with "engineering power" and generality upon which the design of future CALL software and activities can be based. In order to establish such an evidence base for future CALL design, it suggests that CALL…

BEYSIK: Language description and handbook for programmers (system for the collective use of the Institute of Space Research, Academy of Sciences USSR)

NASA Technical Reports Server (NTRS)

Orlov, I. G.

1979-01-01

The BASIC algorithmic language is described, and a guide is presented for the programmer using the language interpreter. The high-level algorithm BASIC is a problem-oriented programming language intended for solution of computational and engineering problems.

Research Reports: 1988 NASA/ASEE Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Freeman, L. Michael (Editor); Chappell, Charles R. (Editor); Cothran, Ernestine K. (Editor); Karr, Gerald R. (Editor)

1988-01-01

The basic objectives are to further the professional knowledge of qualified engineering and science faculty members; to stimulate an exchange of ideas between participants and NASA: to enrich and refresh the research and teaching activities of the participants' institutions; and to contribute to the research objectives of the NASA centers. Topics addressed include: cryogenics; thunderstorm simulation; computer techniques; computer assisted instruction; system analysis weather forecasting; rocket engine design; crystal growth; control systems design; turbine pumps for the Space Shuttle Main engine; electron mobility; heat transfer predictions; rotor dynamics; mathematical models; computational fluid dynamics; and structural analysis.

Towards the Ubiquity of Precollege Engineering Education: From Pedagogical Techniques to the Development of Learning Technologies

ERIC Educational Resources Information Center

Riojas, Mario

2012-01-01

The significance of teaching the basics of engineering education in middle- and high-schools is generally acknowledged by policy makers, teachers and researchers in the U.S.A. as well as a number of developed and developing countries. Nevertheless, engineering topics are rarely covered by precollege curriculums. A key contributing factor is that…

A Study of Second-Year Engineering Students' Alternative Conceptions about Electric Potential, Current Intensity and Ohm's Law

ERIC Educational Resources Information Center

Periago, M. Cristina; Bohigas, Xavier

2005-01-01

The aim of this research was to evaluate and analyse second-year industrial engineering and chemical engineering students prior knowledge of conceptual aspects of "circuit theory". Specifically, we focused on the basic concepts of electric potential and current intensity and on the fundamental relationship between them as expressed by Ohm's law.…

Assessment of the Potential Impact of Combustion Research on Internal Combustion Engine Emission and Fuel Consumption

DOT National Transportation Integrated Search

1979-01-01

A review of the present level of understanding of the basic thermodynamic, fluid dynamic, and chemical kinetic processes which affect the fuel economy and levels of pollutant exhaust products of Diesel, Stratified Charge, and Spark Ignition engines i...

Biomedical applications engineering tasks

NASA Technical Reports Server (NTRS)

Laenger, C. J., Sr.

1976-01-01

The engineering tasks performed in response to needs articulated by clinicians are described. Initial contacts were made with these clinician-technology requestors by the Southwest Research Institute NASA Biomedical Applications Team. The basic purpose of the program was to effectively transfer aerospace technology into functional hardware to solve real biomedical problems.

Multidisciplinary Computational Research

DTIC Science & Technology

2006-07-01

Aeronautical Society Silver Award and Busk Prize (2006);USAF Basic Research Award (2004); AFRL Fellow (1995); Outstanding Scientist of Dayton (2003...Speaker, ASME 2006 Fluids Engineering Conference; Royal Aeronautical Society Silver Award and Busk Prize (2006). Rizzetta, D., Gen. B. Foulois

48 CFR Appendix A to Part 1219 - Appendix A to Part 1219

Code of Federal Regulations, 2014 CFR

2014-10-01

... Rebuilding of engines, turbines, components and weapons equipment J028/J010 (5) ADP Central Processing Units... Engines, Aircraft; and Components 2840 (10) Radar Equipment (except airborne) and Navigation and Navigational Aids (basic research) 5840/AT31 * The industry categories were derived from Federal Procurement...

48 CFR Appendix A to Part 1219 - Appendix A to Part 1219

Code of Federal Regulations, 2012 CFR

2012-10-01

... Rebuilding of engines, turbines, components and weapons equipment J028/J010 (5) ADP Central Processing Units... Engines, Aircraft; and Components 2840 (10) Radar Equipment (except airborne) and Navigation and Navigational Aids (basic research) 5840/AT31 * The industry categories were derived from Federal Procurement...

48 CFR Appendix A to Part 1219 - Appendix A to Part 1219

Code of Federal Regulations, 2013 CFR

2013-10-01

... Rebuilding of engines, turbines, components and weapons equipment J028/J010 (5) ADP Central Processing Units... Engines, Aircraft; and Components 2840 (10) Radar Equipment (except airborne) and Navigation and Navigational Aids (basic research) 5840/AT31 * The industry categories were derived from Federal Procurement...

48 CFR Appendix A to Part 1219 - Appendix A to Part 1219

Code of Federal Regulations, 2011 CFR

2011-10-01

... Rebuilding of engines, turbines, components and weapons equipment J028/J010 (5) ADP Central Processing Units... Engines, Aircraft; and Components 2840 (10) Radar Equipment (except airborne) and Navigation and Navigational Aids (basic research) 5840/AT31 * The industry categories were derived from Federal Procurement...

Increase of Foreign-Born Engineers in U.S. Studied.

ERIC Educational Resources Information Center

Krieger, James

1988-01-01

Summarizes the report of a National Research Council committee. Reports on three basic findings: the proportion of foreign born engineers in the United States has increased over the last 15 years; the increase is disproportionate in the academic sector; and large numbers of students are culturally different. (CW)

Boeing engineers perform air flow balance testing.

NASA Image and Video Library

2017-10-05

Boeing engineers, Chris Chapman, left, Greg Clark, center, and Ashesh Patel, right, perform air flow balance testing on NASA's new Basic Express Racks. The racks, developed at Marshall, will expand the capabilities for science research aboard the International Space Station. Delivery to the station is scheduled for late 2018.

Research requirements for emergency power to permit hover-one-engine-inoperative helicopter operation

NASA Technical Reports Server (NTRS)

Yost, J. H.

1976-01-01

The research and technology demonstration requirements to achieve emergency-power capability for a civil helicopter are documented. The goal for emergency power is the ability to hover with one engine inoperative, transition to minimum-power forward flight, and continue to a safe landing where emergency power may or may not be required. The best method to obtain emergency power is to augment the basic engine power by increasing the engine's speed and turbine-inlet temperature, combined with water-alcohol injection at the engine inlet. Other methods, including turbine boost power and flywheel energy, offer potential for obtaining emergency power for minimum time durations. Costs and schedules are estimated for a research and development program to bring emergency power through a hardware-demonstration test. Interaction of engine emergency-power capability with other helicopter systems is examined.

Application for certification 1988 model year light-duty vehicles - US Technical Research Company (Peugeot)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Every year, each manufacturer of passenger cars, light-duty trucks, motorcycles, or heavy-duty engines submits to EPA an application for certification. In the application, the manufacturer gives a detailed technical description of the vehicles or engines he intends to market during the upcoming model year. These engineering data include explanations and/or drawings that describe engine/vehicle parameters such as basic engine design, fuel systems, ignition systems, and exhaust and evaporative emission control systems.

Jump Starting Research: Preresearch STEM Programs

ERIC Educational Resources Information Center

Schneider, Kimberley R.; VanBennekom, Neyda; Bahr, David; Burkett, Susan; Lusth, John C.; Pressley, Shelley

2016-01-01

Three different course models devoted to preparing science and engineering students for successful research endeavors were offered at three research institutions. Goals of this work include (a) involving students early in their academic career so they can gain the most out of subsequent research experiences and (b) providing basic skills to make…

Towards a portal and search engine to facilitate academic and research collaboration in engineering and education

NASA Astrophysics Data System (ADS)

Bonilla Villarreal, Isaura Nathaly

While international academic and research collaborations are of great importance at this time, it is not easy to find researchers in the engineering field that publish in languages other than English. Because of this disconnect, there exists a need for a portal to find Who's Who in Engineering Education in the Americas. The objective of this thesis is to built an object-oriented architecture for this proposed portal. The Unified Modeling Language (UML) model developed in this thesis incorporates the basic structure of a social network for academic purposes. Reverse engineering of three social networks portals yielded important aspects of their structures that have been incorporated in the proposed UML model. Furthermore, the present work includes a pattern for academic social networks..

Design control for clinical translation of 3D printed modular scaffolds.

PubMed

Hollister, Scott J; Flanagan, Colleen L; Zopf, David A; Morrison, Robert J; Nasser, Hassan; Patel, Janki J; Ebramzadeh, Edward; Sangiorgio, Sophia N; Wheeler, Matthew B; Green, Glenn E

2015-03-01

The primary thrust of tissue engineering is the clinical translation of scaffolds and/or biologics to reconstruct tissue defects. Despite this thrust, clinical translation of tissue engineering therapies from academic research has been minimal in the 27 year history of tissue engineering. Academic research by its nature focuses on, and rewards, initial discovery of new phenomena and technologies in the basic research model, with a view towards generality. Translation, however, by its nature must be directed at specific clinical targets, also denoted as indications, with associated regulatory requirements. These regulatory requirements, especially design control, require that the clinical indication be precisely defined a priori, unlike most academic basic tissue engineering research where the research target is typically open-ended, and furthermore requires that the tissue engineering therapy be constructed according to design inputs that ensure it treats or mitigates the clinical indication. Finally, regulatory approval dictates that the constructed system be verified, i.e., proven that it meets the design inputs, and validated, i.e., that by meeting the design inputs the therapy will address the clinical indication. Satisfying design control requires (1) a system of integrated technologies (scaffolds, materials, biologics), ideally based on a fundamental platform, as compared to focus on a single technology, (2) testing of design hypotheses to validate system performance as opposed to mechanistic hypotheses of natural phenomena, and (3) sequential testing using in vitro, in vivo, large preclinical and eventually clinical tests against competing therapies, as compared to single experiments to test new technologies or test mechanistic hypotheses. Our goal in this paper is to illustrate how design control may be implemented in academic translation of scaffold based tissue engineering therapies. Specifically, we propose to (1) demonstrate a modular platform approach founded on 3D printing for developing tissue engineering therapies and (2) illustrate the design control process for modular implementation of two scaffold based tissue engineering therapies: airway reconstruction and bone tissue engineering based spine fusion.

Design Control for Clinical Translation of 3D Printed Modular Scaffolds

PubMed Central

Hollister, Scott J.; Flanagan, Colleen L.; Zopf, David A.; Morrison, Robert J.; Nasser, Hassan; Patel, Janki J.; Ebramzadeh, Edward; Sangiorgio, Sophia N.; Wheeler, Matthew B.; Green, Glenn E.

2015-01-01

The primary thrust of tissue engineering is the clinical translation of scaffolds and/or biologics to reconstruct tissue defects. Despite this thrust, clinical translation of tissue engineering therapies from academic research has been minimal in the 27 year history of tissue engineering. Academic research by its nature focuses on, and rewards, initial discovery of new phenomena and technologies in the basic research model, with a view towards generality. Translation, however, by its nature must be directed at specific clinical targets, also denoted as indications, with associated regulatory requirements. These regulatory requirements, especially design control, require that the clinical indication be precisely defined a priori, unlike most academic basic tissue engineering research where the research target is typically open-ended, and furthermore requires that the tissue engineering therapy be constructed according to design inputs that ensure it treats or mitigates the clinical indication. Finally, regulatory approval dictates that the constructed system be verified, i.e., proven that it meets the design inputs, and validated, i.e., that by meeting the design inputs the therapy will address the clinical indication. Satisfying design control requires (1) a system of integrated technologies (scaffolds, materials, biologics), ideally based on a fundamental platform, as compared to focus on a single technology, (2) testing of design hypotheses to validate system performance as opposed to mechanistic hypotheses of natural phenomena, and (3) sequential testing using in vitro, in vivo, large preclinical and eventually clinical tests against competing therapies, as compared to single experiments to test new technologies or test mechanistic hypotheses. Our goal in this paper is to illustrate how design control may be implemented in academic translation of scaffold based tissue engineering therapies. Specifically, we propose to (1) demonstrate a modular platform approach founded on 3D printing for developing tissue engineering therapies and (2) illustrate the design control process for modular implementation of two scaffold based tissue engineering therapies: airway reconstruction and bone tissue engineering based spine fusion. PMID:25666115

Research in applied mathematics, numerical analysis, and computer science

NASA Technical Reports Server (NTRS)

1984-01-01

Research conducted at the Institute for Computer Applications in Science and Engineering (ICASE) in applied mathematics, numerical analysis, and computer science is summarized and abstracts of published reports are presented. The major categories of the ICASE research program are: (1) numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; (2) control and parameter identification; (3) computational problems in engineering and the physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and (4) computer systems and software, especially vector and parallel computers.

48 CFR 1834.201 - Policy.

Code of Federal Regulations, 2011 CFR

2011-10-01

... engineering support services, steady state operations, basic and applied research, and routine services such... American National Standards Institute/Electronics Industries Alliance (ANSI/EIA) Standard-748, Earned Value...

48 CFR 1834.201 - Policy.

Code of Federal Regulations, 2013 CFR

2013-10-01

... engineering support services, steady state operations, basic and applied research, and routine services such... American National Standards Institute/Electronics Industries Alliance (ANSI/EIA) Standard-748, Earned Value...

Proposal for continued research in intelligent machines at the Center for Engineering Systems Advanced Research (CESAR) for FY 1988 to FY 1991

DOE Office of Scientific and Technical Information (OSTI.GOV)

Weisbin, C.R.

1987-03-01

This document reviews research accomplishments achieved by the staff of the Center for Engineering Systems Advanced Research (CESAR) during the fiscal years 1984 through 1987. The manuscript also describes future CESAR objectives for the 1988-1991 planning horizon, and beyond. As much as possible, the basic research goals are derived from perceived Department of Energy (DOE) needs for increased safety, productivity, and competitiveness in the United States energy producing and consuming facilities. Research areas covered include the HERMIES-II Robot, autonomous robot navigation, hypercube computers, machine vision, and manipulators.

The research on teaching reformation of photoelectric information science and engineering specialty experiments

NASA Astrophysics Data System (ADS)

Zhu, Zheng; Yang, Fan; Zhang, Yang; Geng, Tao; Li, Yuxiang

2017-08-01

This paper introduced the idea of teaching reformation of photoelectric information science and engineering specialty experiments. The teaching reformation of specialty experiments was analyzed from many aspects, such as construction of specialized laboratory, experimental methods, experiment content, experiment assessing mechanism, and so on. The teaching of specialty experiments was composed of four levels experiments: basic experiments, comprehensive and designing experiments, innovative research experiments and engineering experiments which are aiming at enterprise production. Scientific research achievements and advanced technology on photoelectric technology were brought into the teaching of specialty experiments, which will develop the students' scientific research ability and make them to be the talent suitable for photoelectric industry.

Sandia and General Motors: Advancing Clean Combustion Engines with

Science.gov Websites

Quantitative Risk Assessment Technical Reference for Hydrogen Compatibility of Materials Hydrogen Battery Abuse Testing Laboratory Center for Infrastructure Research and Innovation Combustion Research Facility Joint BioEnergy Institute Close Energy Research Programs ARPA-E Basic Energy Sciences Materials

Semiannual report, 1 April - 30 September 1991

NASA Technical Reports Server (NTRS)

1991-01-01

The major categories of the current Institute for Computer Applications in Science and Engineering (ICASE) research program are: (1) numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; (2) control and parameter identification problems, with emphasis on effective numerical methods; (3) computational problems in engineering and the physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and (4) computer systems and software for parallel computers. Research in these areas is discussed.

Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice

PubMed Central

Al-Himdani, Sarah; Jessop, Zita M.; Al-Sabah, Ayesha; Combellack, Emman; Ibrahim, Amel; Doak, Shareen H.; Hart, Andrew M.; Archer, Charles W.; Thornton, Catherine A.; Whitaker, Iain S.

2017-01-01

Recent advances in microsurgery, imaging, and transplantation have led to significant refinements in autologous reconstructive options; however, the morbidity of donor sites remains. This would be eliminated by successful clinical translation of tissue-engineered solutions into surgical practice. Plastic surgeons are uniquely placed to be intrinsically involved in the research and development of laboratory engineered tissues and their subsequent use. In this article, we present an overview of the field of tissue engineering, with the practicing plastic surgeon in mind. The Medical Research Council states that regenerative medicine and tissue engineering “holds the promise of revolutionizing patient care in the twenty-first century.” The UK government highlighted regenerative medicine as one of the key eight great technologies in their industrial strategy worthy of significant investment. The long-term aim of successful biomanufacture to repair composite defects depends on interdisciplinary collaboration between cell biologists, material scientists, engineers, and associated medical specialties; however currently, there is a current lack of coordination in the field as a whole. Barriers to translation are deep rooted at the basic science level, manifested by a lack of consensus on the ideal cell source, scaffold, molecular cues, and environment and manufacturing strategy. There is also insufficient understanding of the long-term safety and durability of tissue-engineered constructs. This review aims to highlight that individualized approaches to the field are not adequate, and research collaboratives will be essential to bring together differing areas of expertise to expedite future clinical translation. The use of tissue engineering in reconstructive surgery would result in a paradigm shift but it is important to maintain realistic expectations. It is generally accepted that it takes 20–30 years from the start of basic science research to clinical utility, demonstrated by contemporary treatments such as bone marrow transplantation. Although great advances have been made in the tissue engineering field, we highlight the barriers that need to be overcome before we see the routine use of tissue-engineered solutions. PMID:28280722

Tissue-Engineered Solutions in Plastic and Reconstructive Surgery: Principles and Practice.

PubMed

Al-Himdani, Sarah; Jessop, Zita M; Al-Sabah, Ayesha; Combellack, Emman; Ibrahim, Amel; Doak, Shareen H; Hart, Andrew M; Archer, Charles W; Thornton, Catherine A; Whitaker, Iain S

2017-01-01

Recent advances in microsurgery, imaging, and transplantation have led to significant refinements in autologous reconstructive options; however, the morbidity of donor sites remains. This would be eliminated by successful clinical translation of tissue-engineered solutions into surgical practice. Plastic surgeons are uniquely placed to be intrinsically involved in the research and development of laboratory engineered tissues and their subsequent use. In this article, we present an overview of the field of tissue engineering, with the practicing plastic surgeon in mind. The Medical Research Council states that regenerative medicine and tissue engineering "holds the promise of revolutionizing patient care in the twenty-first century." The UK government highlighted regenerative medicine as one of the key eight great technologies in their industrial strategy worthy of significant investment. The long-term aim of successful biomanufacture to repair composite defects depends on interdisciplinary collaboration between cell biologists, material scientists, engineers, and associated medical specialties; however currently, there is a current lack of coordination in the field as a whole. Barriers to translation are deep rooted at the basic science level, manifested by a lack of consensus on the ideal cell source, scaffold, molecular cues, and environment and manufacturing strategy. There is also insufficient understanding of the long-term safety and durability of tissue-engineered constructs. This review aims to highlight that individualized approaches to the field are not adequate, and research collaboratives will be essential to bring together differing areas of expertise to expedite future clinical translation. The use of tissue engineering in reconstructive surgery would result in a paradigm shift but it is important to maintain realistic expectations. It is generally accepted that it takes 20-30 years from the start of basic science research to clinical utility, demonstrated by contemporary treatments such as bone marrow transplantation. Although great advances have been made in the tissue engineering field, we highlight the barriers that need to be overcome before we see the routine use of tissue-engineered solutions.

How to Find Out in: Engineering.

ERIC Educational Resources Information Center

Campana, Jean

This library handbook is a guide for the engineering student. It lists some of the more useful materials and reference books basic to general research and gives their location in the Fogler Library at the University of Maine. Materials are listed in three categories: (1) general reference works--dictionaries, encyclopedias, and handbooks; (2)…

A Practical Teaching Course in Directed Protein Evolution Using the Green Fluorescent Protein as a Model

ERIC Educational Resources Information Center

Ruller, Roberto; Silva-Rocha, Rafael; Silva, Artur; Schneider, Maria Paula Cruz; Ward, Richard John

2011-01-01

Protein engineering is a powerful tool, which correlates protein structure with specific functions, both in applied biotechnology and in basic research. Here, we present a practical teaching course for engineering the green fluorescent protein (GFP) from "Aequorea victoria" by a random mutagenesis strategy using error-prone polymerase…

Multilayer scaffolds in orthopaedic tissue engineering.

PubMed

Atesok, Kivanc; Doral, M Nedim; Karlsson, Jon; Egol, Kenneth A; Jazrawi, Laith M; Coelho, Paulo G; Martinez, Amaury; Matsumoto, Tomoyuki; Owens, Brett D; Ochi, Mitsuo; Hurwitz, Shepard R; Atala, Anthony; Fu, Freddie H; Lu, Helen H; Rodeo, Scott A

2016-07-01

The purpose of this study was to summarize the recent developments in the field of tissue engineering as they relate to multilayer scaffold designs in musculoskeletal regeneration. Clinical and basic research studies that highlight the current knowledge and potential future applications of the multilayer scaffolds in orthopaedic tissue engineering were evaluated and the best evidence collected. Studies were divided into three main categories based on tissue types and interfaces for which multilayer scaffolds were used to regenerate: bone, osteochondral junction and tendon-to-bone interfaces. In vitro and in vivo studies indicate that the use of stratified scaffolds composed of multiple layers with distinct compositions for regeneration of distinct tissue types within the same scaffold and anatomic location is feasible. This emerging tissue engineering approach has potential applications in regeneration of bone defects, osteochondral lesions and tendon-to-bone interfaces with successful basic research findings that encourage clinical applications. Present data supporting the advantages of the use of multilayer scaffolds as an emerging strategy in musculoskeletal tissue engineering are promising, however, still limited. Positive impacts of the use of next generation scaffolds in orthopaedic tissue engineering can be expected in terms of decreasing the invasiveness of current grafting techniques used for reconstruction of bone and osteochondral defects, and tendon-to-bone interfaces in near future.

48 CFR 1834.201 - Policy.

Code of Federal Regulations, 2010 CFR

2010-10-01

.../project manager. (iv) EVM is not required on contracts for non-developmental engineering support services, steady state operations, basic and applied research, and routine services such as janitorial services or...

Physics for excited neutrons

NASA Astrophysics Data System (ADS)

Cartlidge, Edwin

2017-01-01

Some scientists claim they can control genetically engineered neurons using magnetic fields. Have they and the high-profile journals that published their research failed to understand basic physics? Edwin Cartlidge investigates

Research on the Development and Enlightenment of Urban Environmental Engineering

NASA Astrophysics Data System (ADS)

Tian, Mingjing; Li, Guanglou; Zhang, Lu; Shou, Youping; Li, Yajuan; Ye, Wei; Xu, Jing

2018-04-01

In recent years, under the promotion of reform and opening up, China's economic development has greatly accelerated, urbanization is also gradually accelerated. In the process of urbanization, there are many problems. The development of environmental engineering is one of the most important points. While building our living environment; we should also pay attention to the implementation of sustainable development strategies. First of all, This paper describes basic situation of environmental engineering, and finally provided some measures to promote the strengthening of China's environmental engineering

Generalized simulation technique for turbojet engine system analysis

NASA Technical Reports Server (NTRS)

Seldner, K.; Mihaloew, J. R.; Blaha, R. J.

1972-01-01

A nonlinear analog simulation of a turbojet engine was developed. The purpose of the study was to establish simulation techniques applicable to propulsion system dynamics and controls research. A schematic model was derived from a physical description of a J85-13 turbojet engine. Basic conservation equations were applied to each component along with their individual performance characteristics to derive a mathematical representation. The simulation was mechanized on an analog computer. The simulation was verified in both steady-state and dynamic modes by comparing analytical results with experimental data obtained from tests performed at the Lewis Research Center with a J85-13 engine. In addition, comparison was also made with performance data obtained from the engine manufacturer. The comparisons established the validity of the simulation technique.

Advanced fabrication techniques for hydrogen-cooled engine structures

NASA Technical Reports Server (NTRS)

Buchmann, O. A.; Arefian, V. V.; Warren, H. A.; Vuigner, A. A.; Pohlman, M. J.

1985-01-01

Described is a program for development of coolant passage geometries, material systems, and joining processes that will produce long-life hydrogen-cooled structures for scramjet applications. Tests were performed to establish basic material properties, and samples constructed and evaluated to substantiate fabrication processes and inspection techniques. Results of the study show that the basic goal of increasing the life of hydrogen-cooled structures two orders of magnitude relative to that of the Hypersonic Research Engine can be reached with available means. Estimated life is 19000 cycles for the channels and 16000 cycles for pin-fin coolant passage configurations using Nickel 201. Additional research is required to establish the fatigue characteristics of dissimilar-metal coolant passages (Nickel 201/Inconel 718) and to investigate the embrittling effects of the hydrogen coolant.

3D Bio-Printing Review

NASA Astrophysics Data System (ADS)

Du, Xianbin

2018-01-01

Ultimate goal of tissue engineering is to replace pathological or necrotic body tissue or organ by artificial tissue or organ and tissue engineering is a very promising research field. 3D bio-printing is a kind of emerging technologies and a branch of tissue engineering. It has made significant progress in the past decade. 3D bio-printing can realize tissue and organ construction in vitro and has wide application in basic research and pharmacy. This paper is to make an analysis and review on 3D bio-printing from the perspectives of bioink, printing technology and technology application.

Status of Real-Time Laser Based Ion Engine Diagnostics at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Domonkos, Matthew T.; Williams, George J., Jr.

2001-01-01

The development status of laser based erosion diagnostics for ion engines at the NASA Glenn Research Center is discussed. The diagnostics are being developed to enhance component life-prediction capabilities. A direct measurement of the erosion product density using laser induced fluorescence (LIF) is described. Erosion diagnostics based upon evaluation of the ion dynamics are also under development, and the basic approach is presented. The planned implementation of the diagnostics is discussed.

EngineSim: Turbojet Engine Simulator Adapted for High School Classroom Use

NASA Technical Reports Server (NTRS)

Petersen, Ruth A.

2001-01-01

EngineSim is an interactive educational computer program that allows users to explore the effect of engine operation on total aircraft performance. The software is supported by a basic propulsion web site called the Beginner's Guide to Propulsion, which includes educator-created, web-based activities for the classroom use of EngineSim. In addition, educators can schedule videoconferencing workshops in which EngineSim's creator demonstrates the software and discusses its use in the educational setting. This software is a product of NASA Glenn Research Center's Learning Technologies Project, an educational outreach initiative within the High Performance Computing and Communications Program.

Software Engineering Laboratory (SEL) relationships, models, and management rules

NASA Technical Reports Server (NTRS)

Decker, William; Hendrick, Robert; Valett, Jon D.

1991-01-01

Over 50 individual Software Engineering Laboratory (SEL) research results, extracted from a review of published SEL documentation, that can be applied directly to managing software development projects are captured. Four basic categories of results are defined and discussed - environment profiles, relationships, models, and management rules. In each category, research results are presented as a single page that summarizes the individual result, lists potential uses of the result by managers, and references the original SEL documentation where the result was found. The document serves as a concise reference summary of applicable research for SEL managers.

Problem Solving Method Based on E-Learning System for Engineering Education

ERIC Educational Resources Information Center

Khazaal, Hasan F.

2015-01-01

Encouraging engineering students to handle advanced technology with multimedia, as well as motivate them to have the skills of solving the problem, are the missions of the teacher in preparing students for a modern professional career. This research proposes a scenario of problem solving in basic electrical circuits based on an e-learning system…

The Construction and Practice of Classified Talent Cultivation System Combining with Professional Certification

ERIC Educational Resources Information Center

Jianwei, Yang; Aihua, Zhu; Yuanyuan, Zhang; Chunqing, Zhao

2016-01-01

According to the idea of CDIO engineering education, this paper, combing with professional certification, makes training plan of Urban Rail Transit Vehicles Engineering direction in our school on the basis of research on universities at home and abroad. It strengthens the teaching of basic subjects and increases the weeks of practice link in the…

The 1990 progress report and future plans

NASA Technical Reports Server (NTRS)

Friedland, Peter; Zweben, Monte; Compton, Michael

1990-01-01

This document describes the progress and plans of the Artificial Intelligence Research Branch (RIA) at ARC in 1990. Activities span a range from basic scientific research to engineering development and to fielded NASA applications, particularly those applications that are enabled by basic research carried out at RIA. Work is conducted in-house and through collaborative partners in academia and industry. Our major focus is on a limited number of research themes with a dual commitment to technical excellence and proven applicability to NASA short, medium, and long-term problems. RIA acts as the Agency's lead organization for research aspects of artificial intelligence, working closely with a second research laboratory at JPL and AI applications groups at all NASA centers.

Nuclear Reactor Physics

NASA Astrophysics Data System (ADS)

Stacey, Weston M.

2001-02-01

An authoritative textbook and up-to-date professional's guide to basic and advanced principles and practices Nuclear reactors now account for a significant portion of the electrical power generated worldwide. At the same time, the past few decades have seen an ever-increasing number of industrial, medical, military, and research applications for nuclear reactors. Nuclear reactor physics is the core discipline of nuclear engineering, and as the first comprehensive textbook and reference on basic and advanced nuclear reactor physics to appear in a quarter century, this book fills a large gap in the professional literature. Nuclear Reactor Physics is a textbook for students new to the subject, for others who need a basic understanding of how nuclear reactors work, as well as for those who are, or wish to become, specialists in nuclear reactor physics and reactor physics computations. It is also a valuable resource for engineers responsible for the operation of nuclear reactors. Dr. Weston Stacey begins with clear presentations of the basic physical principles, nuclear data, and computational methodology needed to understand both the static and dynamic behaviors of nuclear reactors. This is followed by in-depth discussions of advanced concepts, including extensive treatment of neutron transport computational methods. As an aid to comprehension and quick mastery of computational skills, he provides numerous examples illustrating step-by-step procedures for performing the calculations described and chapter-end problems. Nuclear Reactor Physics is a useful textbook and working reference. It is an excellent self-teaching guide for research scientists, engineers, and technicians involved in industrial, research, and military applications of nuclear reactors, as well as government regulators who wish to increase their understanding of nuclear reactors.

Ethical Considerations in Tissue Engineering Research: Case Studies in Translation

PubMed Central

Baker, Hannah B.; McQuilling, John P.

2016-01-01

Tissue engineering research is a complex process that requires investigators to focus on the relationship between their research and anticipated gains in both knowledge and treatment improvements. The ethical considerations arising from tissue engineering research are similarly complex when addressing the translational progression from bench to bedside, and investigators in the field of tissue engineering act as moral agents at each step of their research along the translational pathway, from early benchwork and preclinical studies to clinical research. This review highlights the ethical considerations and challenges at each stage of research, by comparing issues surrounding two translational tissue engineering technologies: the bioartificial pancreas and a tissue engineered skeletal muscle construct. We present relevant ethical issues and questions to consider at each step along the translational pathway, from the basic science bench to preclinical research to first-in-human clinical trials. Topics at the bench level include maintaining data integrity, appropriate reporting and dissemination of results, and ensuring that studies are designed to yield results suitable for advancing research. Topics in preclinical research include the principle of “modest translational distance” and appropriate animal models. Topics in clinical research include key issues that arise in early-stage clinical trials, including selection of patient-subjects, disclosure of uncertainty, and defining success. The comparison of these two technologies and their ethical issues brings to light many challenges for translational tissue engineering research and provides guidance for investigators engaged in development of any tissue engineering technology. PMID:26282436

Ethical considerations in tissue engineering research: Case studies in translation.

PubMed

Baker, Hannah B; McQuilling, John P; King, Nancy M P

2016-04-15

Tissue engineering research is a complex process that requires investigators to focus on the relationship between their research and anticipated gains in both knowledge and treatment improvements. The ethical considerations arising from tissue engineering research are similarly complex when addressing the translational progression from bench to bedside, and investigators in the field of tissue engineering act as moral agents at each step of their research along the translational pathway, from early benchwork and preclinical studies to clinical research. This review highlights the ethical considerations and challenges at each stage of research, by comparing issues surrounding two translational tissue engineering technologies: the bioartificial pancreas and a tissue engineered skeletal muscle construct. We present relevant ethical issues and questions to consider at each step along the translational pathway, from the basic science bench to preclinical research to first-in-human clinical trials. Topics at the bench level include maintaining data integrity, appropriate reporting and dissemination of results, and ensuring that studies are designed to yield results suitable for advancing research. Topics in preclinical research include the principle of "modest translational distance" and appropriate animal models. Topics in clinical research include key issues that arise in early-stage clinical trials, including selection of patient-subjects, disclosure of uncertainty, and defining success. The comparison of these two technologies and their ethical issues brings to light many challenges for translational tissue engineering research and provides guidance for investigators engaged in development of any tissue engineering technology. Copyright © 2015 Elsevier Inc. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Klipstein, David H.; Robinson, Sharon

The Reaction Engineering Roadmap is a part of an industry- wide effort to create a blueprint of the research and technology milestones that are necessary to achieve longterm industry goals. This report documents the results of a workshop focused on the research needs, technology barriers, and priorities of the chemical industry as they relate to reaction engineering viewed first by industrial use (basic chemicals; specialty chemicals; pharmaceuticals; and polymers) and then by technology segment (reactor system selection, design, and scale-up; chemical mechanism development and property estimation; dealing with catalysis; and new, nonstandard reactor types).

General Aviation Pilot Advisory and Training System (GAPATS)

NASA Technical Reports Server (NTRS)

Painter, John; Ward, Donald T.; Kelly, Wallace; Crump, John W.; Phillips, Ron; Trang, Jeff; Lee, Kris; Branham, Paul A.; Krishnamurthy, Karthik; Alcorn, William P., Jr.;

Program Manager: Journal of the Defense Systems Management College. Volume 17, Number 2, March-April 1988,

DTIC Science & Technology

1988-04-01

Engineering Educa- -Zhejiang Provincial Society of tion College Mechanical Engineering - Bejing Institute of Technology -Zhejiang Commission, China ...17,445 50 50 ( China Lake), and the Air Force Cam- 1970 16,316 52 48 bridge Research Laboratory. 1975 14,537 51 49 1980 16,542 50 50 The FFRDCs basically...Army ( Opera - Brassey’s International Defense tions Research). She holds a B.A. Gains Publishers, 1984), p. 9. degree in mathematics from the Col

A Case for Basic Rotating Detonation Engine Research

NASA Technical Reports Server (NTRS)

Paxson, Daniel E.

2016-01-01

A brief review is provided covering the benefits to air breathing and chemical rocket propulsion found from pressure gain combustion in general, and rotating detonation in particular. Challenges are also identified.

Basic energy sciences: Summary of accomplishments

NASA Astrophysics Data System (ADS)

1990-05-01

For more than four decades, the Department of Energy, including its predecessor agencies, has supported a program of basic research in nuclear- and energy related sciences, known as Basic Energy Sciences. The purpose of the program is to explore fundamental phenomena, create scientific knowledge, and provide unique user facilities necessary for conducting basic research. Its technical interests span the range of scientific disciplines: physical and biological sciences, geological sciences, engineering, mathematics, and computer sciences. Its products and facilities are essential to technology development in many of the more applied areas of the Department's energy, science, and national defense missions. The accomplishments of Basic Energy Sciences research are numerous and significant. Not only have they contributed to Departmental missions, but have aided significantly the development of technologies which now serve modern society daily in business, industry, science, and medicine. In a series of stories, this report highlights 22 accomplishments, selected because of their particularly noteworthy contributions to modern society. A full accounting of all the accomplishments would be voluminous. Detailed documentation of the research results can be found in many thousands of articles published in peer-reviewed technical literature.

Basic Energy Sciences: Summary of Accomplishments

DOE R&D Accomplishments Database

1990-05-01

For more than four decades, the Department of Energy, including its predecessor agencies, has supported a program of basic research in nuclear- and energy-related sciences, known as Basic Energy Sciences. The purpose of the program is to explore fundamental phenomena, create scientific knowledge, and provide unique user'' facilities necessary for conducting basic research. Its technical interests span the range of scientific disciplines: physical and biological sciences, geological sciences, engineering, mathematics, and computer sciences. Its products and facilities are essential to technology development in many of the more applied areas of the Department's energy, science, and national defense missions. The accomplishments of Basic Energy Sciences research are numerous and significant. Not only have they contributed to Departmental missions, but have aided significantly the development of technologies which now serve modern society daily in business, industry, science, and medicine. In a series of stories, this report highlights 22 accomplishments, selected because of their particularly noteworthy contributions to modern society. A full accounting of all the accomplishments would be voluminous. Detailed documentation of the research results can be found in many thousands of articles published in peer-reviewed technical literature.

Handbook of Industrial Engineering Equations, Formulas, and Calculations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Badiru, Adedeji B; Omitaomu, Olufemi A

The first handbook to focus exclusively on industrial engineering calculations with a correlation to applications, Handbook of Industrial Engineering Equations, Formulas, and Calculations contains a general collection of the mathematical equations often used in the practice of industrial engineering. Many books cover individual areas of engineering and some cover all areas, but none covers industrial engineering specifically, nor do they highlight topics such as project management, materials, and systems engineering from an integrated viewpoint. Written by acclaimed researchers and authors, this concise reference marries theory and practice, making it a versatile and flexible resource. Succinctly formatted for functionality, the bookmore » presents: Basic Math Calculations; Engineering Math Calculations; Production Engineering Calculations; Engineering Economics Calculations; Ergonomics Calculations; Facility Layout Calculations; Production Sequencing and Scheduling Calculations; Systems Engineering Calculations; Data Engineering Calculations; Project Engineering Calculations; and Simulation and Statistical Equations. It has been said that engineers make things while industrial engineers make things better. To make something better requires an understanding of its basic characteristics and the underlying equations and calculations that facilitate that understanding. To do this, however, you do not have to be computational experts; you just have to know where to get the computational resources that are needed. This book elucidates the underlying equations that facilitate the understanding required to improve design processes, continuously improving the answer to the age-old question: What is the best way to do a job?« less

The Brazilian Portuguese Lexicon: An Instrument for Psycholinguistic Research

PubMed Central

Estivalet, Gustavo L.; Meunier, Fanny

2015-01-01

In this article, we present the Brazilian Portuguese Lexicon, a new word-based corpus for psycholinguistic and computational linguistic research in Brazilian Portuguese. We describe the corpus development, the specific characteristics on the internet site and database for user access. We also perform distributional analyses of the corpus and comparisons to other current databases. Our main objective was to provide a large, reliable, and useful word-based corpus with a dynamic, easy-to-use, and intuitive interface with free internet access for word and word-criteria searches. We used the Núcleo Interinstitucional de Linguística Computacional’s corpus as the basic data source and developed the Brazilian Portuguese Lexicon by deriving and adding metalinguistic and psycholinguistic information about Brazilian Portuguese words. We obtained a final corpus with more than 30 million word tokens, 215 thousand word types and 25 categories of information about each word. This corpus was made available on the internet via a free-access site with two search engines: a simple search and a complex search. The simple engine basically searches for a list of words, while the complex engine accepts all types of criteria in the corpus categories. The output result presents all entries found in the corpus with the criteria specified in the input search and can be downloaded as a.csv file. We created a module in the results that delivers basic statistics about each search. The Brazilian Portuguese Lexicon also provides a pseudoword engine and specific tools for linguistic and statistical analysis. Therefore, the Brazilian Portuguese Lexicon is a convenient instrument for stimulus search, selection, control, and manipulation in psycholinguistic experiments, as also it is a powerful database for computational linguistics research and language modeling related to lexicon distribution, functioning, and behavior. PMID:26630138

The Brazilian Portuguese Lexicon: An Instrument for Psycholinguistic Research.

PubMed

Estivalet, Gustavo L; Meunier, Fanny

2015-01-01

In this article, we present the Brazilian Portuguese Lexicon, a new word-based corpus for psycholinguistic and computational linguistic research in Brazilian Portuguese. We describe the corpus development, the specific characteristics on the internet site and database for user access. We also perform distributional analyses of the corpus and comparisons to other current databases. Our main objective was to provide a large, reliable, and useful word-based corpus with a dynamic, easy-to-use, and intuitive interface with free internet access for word and word-criteria searches. We used the Núcleo Interinstitucional de Linguística Computacional's corpus as the basic data source and developed the Brazilian Portuguese Lexicon by deriving and adding metalinguistic and psycholinguistic information about Brazilian Portuguese words. We obtained a final corpus with more than 30 million word tokens, 215 thousand word types and 25 categories of information about each word. This corpus was made available on the internet via a free-access site with two search engines: a simple search and a complex search. The simple engine basically searches for a list of words, while the complex engine accepts all types of criteria in the corpus categories. The output result presents all entries found in the corpus with the criteria specified in the input search and can be downloaded as a.csv file. We created a module in the results that delivers basic statistics about each search. The Brazilian Portuguese Lexicon also provides a pseudoword engine and specific tools for linguistic and statistical analysis. Therefore, the Brazilian Portuguese Lexicon is a convenient instrument for stimulus search, selection, control, and manipulation in psycholinguistic experiments, as also it is a powerful database for computational linguistics research and language modeling related to lexicon distribution, functioning, and behavior.

76 FR 7526 - Major System Acquisition; Earned Value Management

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-10

... for engineering support services, steady state operations, basic and applied research, and routine... the requirements in the NASA NPR to apply EVM principles at the program/project level; nor is it...

An update of engine system research at the Army Propulsion Directorate

NASA Technical Reports Server (NTRS)

Bobula, George A.

1990-01-01

The Small Turboshaft Engine Research (STER) program provides a vehicle for evaluating the application of emerging technologies to Army turboshaft engine systems and to investigate related phenomena. Capitalizing on the resources at hand, in the form of both the NASA facilities and the Army personnel, the program goal of developing a physical understanding of engine system dynamics and/or system interactions is being realized. STER entries investigate concepts and components developed both in-house and out-of-house. Emphasis is placed upon evaluations which evolved from on-going basic research and advanced development programs. Army aviation program managers are also encouraged to make use of STER resources, both people and facilities. The STER personnel have established their reputations as experts in the fields of engine system experimental evaluations and engine system related phenomena. The STER facility has STER program provides the Army aviation community the opportunity to perform system level investigations, and then to offer the findings to the entire engine community for their consideration in next generation propulsion systems. In this way results of the fundamental research being conducted to meet small turboshaft engine technology challenges expeditiously find their way into that next generation of propulsion systems.

Qualities Required from Engineers of the Global Times

NASA Astrophysics Data System (ADS)

Senuma, Takehide

In this paper, the qualities and characteristics required from an engineer who works globally are discussed based on my own experience of a joint research project with a European company. The most important qualities and characteristics are integrity, one‧s own initiative, basic and expert knowledge, creativity, communicative skills and broad world view. Having initiative seems to be especially significant but is a weak point of young engineers in Japan at present. Ways to develop students‧ initiative are discussed in detail from a view point of the engineering education.

[NEW PROGRESS OF ACELLULAR FISH SKIN AS NOVEL TISSUE ENGINEERED SCAFFOLD].

PubMed

Wei, Xiaojuan; Wang, Nanping; He, Lan; Guo, Xiuyu; Gu, Qisheng

2016-11-08

To review the recent research progress of acellular fish skin as a tissue engineered scaffold, and to analyze the feasibility and risk management in clinical application. The research and development, application status of acellular fish skin as a tissue engineered scaffold were comprehensively analyzed, and then several key points were put forward. Acellular fish skin has a huge potential in clinical practice as novel acellular extracellular matrix, but there have been no related research reports up to now in China. As an emerging point of translational medicine, investigation of acellular fish skin is mainly focused on artificial skin, surgical patch, and wound dressings. Development of acellular fish skin-based new products is concerned to be clinical feasible and necessary, but a lot of applied basic researches should be carried out.

A woman like you: Women scientists and engineers at Brookhaven National Laboratory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benkovitz, Carmen; Bernholc, Nicole; Cohen, Anita

1991-01-01

This publication by the women in Science and Engineering introduces career possibilities in science and engineering. It introduces what work and home life are like for women who have already entered these fields. Women at Brookhaven National Laboratory work in a variety of challenging research roles -- from biologist and environmental scientist to safety engineer, from patent lawyer to technician. Brookhaven National Laboratory is a multi-program laboratory which carries out basic and applied research in the physical, biomedical and environmental sciences and in selected energy technologies. The Laboratory is managed by Associated University, Inc., under contract with the US Departmentmore » of Energy. Brookhaven and the other national laboratories, because of their enormous research resources, can play a critical role in a education and training of the workforce.« less

A woman like you: Women scientists and engineers at Brookhaven National Laboratory. Careers in action

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-12-31

This publication by the women in Science and Engineering introduces career possibilities in science and engineering. It introduces what work and home life are like for women who have already entered these fields. Women at Brookhaven National Laboratory work in a variety of challenging research roles -- from biologist and environmental scientist to safety engineer, from patent lawyer to technician. Brookhaven National Laboratory is a multi-program laboratory which carries out basic and applied research in the physical, biomedical and environmental sciences and in selected energy technologies. The Laboratory is managed by Associated University, Inc., under contract with the US Departmentmore » of Energy. Brookhaven and the other national laboratories, because of their enormous research resources, can play a critical role in a education and training of the workforce.« less

FY08 Engineering Research and Technology Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Minichino, C; McNichols, D

2009-02-24

This report summarizes the core research, development, and technology accomplishments in Lawrence Livermore National Laboratory's Engineering Directorate for FY2008. These efforts exemplify Engineering's more than 50-year history of developing and applying the technologies needed to support the Laboratory's national security missions. A partner in every major program and project at the Laboratory throughout its existence, Engineering has prepared for this role with a skilled workforce and technical resources developed through both internal and external venues. These accomplishments embody Engineering's mission: 'Enable program success today and ensure the Laboratory's vitality tomorrow.' Engineering's mission is carried out through basic research and technologymore » development. Research is the vehicle for creating competencies that are cutting-edge, or require discovery-class groundwork to be fully understood. Our technology efforts are discipline-oriented, preparing research breakthroughs for broader application to a variety of Laboratory needs. The term commonly used for technology-based projects is 'reduction to practice.' As we pursue this two-pronged approach, an enormous range of technological capabilities result. This report combines our work in research and technology into one volume, organized into thematic technical areas: Engineering Modeling and Simulation; Measurement Technologies; Micro/Nano-Devices and Structures; Engineering Systems for Knowledge and Inference; and Energy Manipulation. Our investments in these areas serve not only known programmatic requirements of today and tomorrow, but also anticipate the breakthrough engineering innovations that will be needed in the future.« less

Computer Simulation of the VASIMR Engine

NASA Technical Reports Server (NTRS)

Garrison, David

2005-01-01

The goal of this project is to develop a magneto-hydrodynamic (MHD) computer code for simulation of the VASIMR engine. This code is designed be easy to modify and use. We achieve this using the Cactus framework, a system originally developed for research in numerical relativity. Since its release, Cactus has become an extremely powerful and flexible open source framework. The development of the code will be done in stages, starting with a basic fluid dynamic simulation and working towards a more complex MHD code. Once developed, this code can be used by students and researchers in order to further test and improve the VASIMR engine.

Doing Systems Engineering Without Thinking About It at NASA Dryden Flight Research Center

NASA Technical Reports Server (NTRS)

Bohn-Meyer, Marta; Kilp, Stephen; Chun, Peggy; Mizukami, Masashi

2004-01-01

When asked about his processes in designing a new airplane, Burt Rutan responded: ...there is always a performance requirement. So I start with the basic physics of an airplane that can get those requirements, and that pretty much sizes an airplane... Then I look at the functionality... And then I try a lot of different configurations to meet that, and then justify one at a time, throwing them out... Typically I'll have several different configurations... But I like to experiment, certainly. I like to see if there are other ways to provide the utility. This kind of thinking engineering as a total systems engineering approach is what is being instilled in all engineers at the NASA Dryden Flight Research Center.

Engineering Data Compendium. Human Perception and Performance, Volume 2

NASA Technical Reports Server (NTRS)

Boff, Kenneth R. (Editor); Lincoln, Janet E. (Editor)

1988-01-01

The concept underlying the Engineering Data Compendium was the product of a Research and Development program (Integrated Perceptual Information for Designers project) aimed at facilitating the application of basic research findings in human performance to the design of military crew systems. The principal objective was to develop a workable strategy for: (1) identifying and distilling information of potential value to system design from existing research literature, and (2) presenting this technical information in a way that would aid its accessibility, interpretability, and applicability by system designers. The present volumes of the Engineering Data Compendium represent the first implementation of this strategy. This is Volume 2, which contains sections on Information Storage and Retrieval, Spatial Awareness, Perceptual Organization, and Attention and Allocation of Resources.

Engineering data compendium. Human perception and performance, volume 3

NASA Technical Reports Server (NTRS)

Boff, Kenneth R. (Editor); Lincoln, Janet E. (Editor)

1988-01-01

The concept underlying the Engineering Data Compendium was the product of a research and development program (Integrated Perceptual Information for Designers project) aimed at facilitating the application of basic research findings in human performance to the design of military crew systems. The principal objective was to develop a workable strategy for: (1) identifying and distilling information of potential value to system design from existing research literature, and (2) presenting this technical information in a way that would aid its accessibility, interpretability, and applicability by system designers. The present four volumes of the Engineering Data Compendium represent the first implementation of this strategy. This is Volume 3, containing sections on Human Language Processing, Operator Motion Control, Effects of Environmental Stressors, Display Interfaces, and Control Interfaces (Real/Virtual).

Engineering data compendium. Human perception and performance. User's guide

NASA Technical Reports Server (NTRS)

Boff, Kenneth R. (Editor); Lincoln, Janet E. (Editor)

1988-01-01

The concept underlying the Engineering Data Compendium was the product of a research and development program (Integrated Perceptual Information for Designers project) aimed at facilitating the application of basic research findings in human performance to the design and military crew systems. The principal objective was to develop a workable strategy for: (1) identifying and distilling information of potential value to system design from the existing research literature, and (2) presenting this technical information in a way that would aid its accessibility, interpretability, and applicability by systems designers. The present four volumes of the Engineering Data Compendium represent the first implementation of this strategy. This is the first volume, the User's Guide, containing a description of the program and instructions for its use.

An update of engine system research at the Army Propulsion Directorate

NASA Technical Reports Server (NTRS)

Bobula, George A.

1990-01-01

The Small Turboshaft Engine Research (STER) program provides a vehicle for evaluating the application of emerging technologies to Army turboshaft engine systems and to investigate related phenomena. Capitalizing on the resources at hand, in the form of both the NASA facilities and the Army personnel, the program goal of developing a physical understanding of engine system dynamics and/or system interactions is being realized. STER entries investigate concepts and components developed both in-house and out-of-house. Emphasis is placed upon evaluations which have evolved from on-going basic research and advanced development programs. Army aviation program managers are also encouraged to make use of STER resources, both people and facilities. The STER personnel have established their reputations as experts in the fields of engine system experimental evaluations and engine system related phenomena. The STER facility has demonstrated its utility in both research and development programs. The STER program provides the Army aviation community the opportunity to perform system level investigations, and then to offer the findings to the entire engine community for their consideration in next generation propulsion systems. In this way results of the fundamental research being conducted to meet small turboshaft engine technology challenges expeditiously find their way into that next generation of propulsion systems.

NREL Photovoltaic Program FY 1995 annual report

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-06-01

This report summarizes the in-house and subcontracted R&D activities from Oct. 1994 through Sept. 1995; their objectives are to conduct basic, applied, and engineering research, manage subcontracted R&D projects, perform research complementary to subcontracted work, develop and maintain state-of-the-art measurement and device capabilities, develop PV manufacturing technology and modules, transfer results to industry, and evolve viable partnerships for PV systems and market development. The research activities are grouped into 5 sections: crystalline Si and advanced devices, thin-film PV, PV manufacturing, PV module and system performance and engineering, and PV applications and market development.

Opportunities for research in aerothermodynamics

NASA Technical Reports Server (NTRS)

Graham, R. W.

1983-01-01

"Aerothermodynamics' involves the disciplines of chemistry, thermodynamics, fluid mechanics and heat transfer which have collaborative importance in propulsion systems. There are growing opportunities for the further application of these disciplines to improve the methodology for the design of advanced gas turbines; particularly, the combustor and turbine. Design procedures follow empirical or cut and try guidelines. The tremendous advances in computational analysis and in instrumentation techniques hold promise for research answers to complex physical processes that are currently not well understood. The transfer of basic research understanding to engineering design should result in shorter, less expensive development commitments for engines. The status and anticipated opportunities in research topics relevant to combustors and turbines is reviewed.

Rocket Propulsion Research at Lewis Research Center

NASA Technical Reports Server (NTRS)

Dawson, Virginia P.

1992-01-01

A small contingent of engineers at NASA Lewis Research Center pioneered in basic research on liquid propellants for rockets shortly after World War II. Carried on through the 1950s, this work influenced the important early decisions made by Abe Silverstein when he took charge of the Office of Space Flight Programs for NASA. He strongly supported the development of liquid hydrogen as a propulsion fuel in the face of resistance from Wernher von Braun. Members of the Lewis staff played an important role in bringing liquid hydrogen technology to the point of reliability through their management of the Centaur Program. This paper demonstrates how the personality and engineering intuition of Abe Silverstein shaped the Centaur program and left a lasting imprint on the laboratory research tradition. Many of the current leaders of Lewis Research Center received their first hands-on engineering experience when they worked on the Centaur program in the 1960s.

S.E.E.ing the Future: Science, Engineering and Education. Commentary from the Scientific Grassroots. A White Paper on the Issues and Need for Public Funding of Basic Science and Engineering Research.

ERIC Educational Resources Information Center

Jemison, Mae C., Ed.

This document reports on the results of an ad hoc workshop called "S.E.E.ing the Future: Science Engineering and Education" Held at Dartmouth College in November of 2000 and sponsored by Dartmouth, the National Science Foundation, the Dow Chemical Company, and Science Service of Washington, DC. This transdisciplinary conference was one of a series…

Astronomy as a Tool for Training the Next Generation Technical Workforce

NASA Astrophysics Data System (ADS)

Romero, V.; Walsh, G.; Ryan, W.; Ryan, E.

A major challenge for today's institutes of higher learning is training the next generation of scientists, engineers, and optical specialists to be proficient in the latest technologies they will encounter when they enter the workforce. Although research facilities can offer excellent hands-on instructional opportunities, integrating such experiential learning into academic coursework without disrupting normal operations at such facilities can be difficult. Also, motivating entry level students to increase their skill levels by undertaking and successfully completing difficult coursework can require more creative instructional approaches, including fostering a fun, non-threatening environment for enhancing basic abilities. Astronomy is a universally appealing subject area, and can be very effective as a foundation for cultivating advanced competencies. We report on a project underway at the New Mexico Institute of Mining and Technology (NM Tech), a science and engineering school in Socorro, NM, to incorporate a state-of-the-art optical telescope and laboratory experiments into an entry-level course in basic engineering. Students enrolled in an explosive engineering course were given a topical problem in Planetary Astronomy: they were asked to develop a method to energetically mitigate a potentially hazardous impact between our planet and a Near-Earth asteroid to occur sometime in the future. They were first exposed to basic engineering training in the areas of fracture and material response to failure under different environmental conditions through lectures and traditional laboratory exercises. The students were then given access to NM Tech's Magdalena Ridge Observatory's (MRO) 2.4-meter telescope to collect physical characterization data, (specifically shape information) on two potentially hazardous asteroids (one roughly spherical, the other an elongated ellipsoid). Finally, the students used NM Tech's Energetic Materials Research and Testing Center (EMRTC) to perform field experiments to discern how an object's shape affects disruptive outcomes, and what must be factored into mitigation schemes to attain the desired result of complete destruction of the object. The scientific findings (details will be presented) derived by the students were valuable, and the students benefited from this non-traditional teaching approach such that they acquired a superior appreciation for research and experimentation, and exited the course with an increased motivation to continue their engineering training.

Overview of CMC Research at NASA Glenn Research Center

NASA Technical Reports Server (NTRS)

Grady, Joseph E.

2011-01-01

CMC technology development in the Ceramics Branch at NASA Glenn Research Center addresses Aeronautics propulsion goals across subsonic, supersonic and hypersonic flight regimes. Combustor, turbine and exhaust nozzle applications of CMC materials will enable NASA to demonstrate reduced fuel consumption, emissions, and noise in advanced gas turbine engines. Applications ranging from basic Fundamental Aeronautics research activities to technology demonstrations in the new Integrated Systems Research Program will be discussed.

Artificial Intelligence Research Branch future plans

NASA Technical Reports Server (NTRS)

Stewart, Helen (Editor)

1992-01-01

This report contains information on the activities of the Artificial Intelligence Research Branch (FIA) at NASA Ames Research Center (ARC) in 1992, as well as planned work in 1993. These activities span a range from basic scientific research through engineering development to fielded NASA applications, particularly those applications that are enabled by basic research carried out in FIA. Work is conducted in-house and through collaborative partners in academia and industry. All of our work has research themes with a dual commitment to technical excellence and applicability to NASA short, medium, and long-term problems. FIA acts as the Agency's lead organization for research aspects of artificial intelligence, working closely with a second research laboratory at the Jet Propulsion Laboratory (JPL) and AI applications groups throughout all NASA centers. This report is organized along three major research themes: (1) Planning and Scheduling: deciding on a sequence of actions to achieve a set of complex goals and determining when to execute those actions and how to allocate resources to carry them out; (2) Machine Learning: techniques for forming theories about natural and man-made phenomena; and for improving the problem-solving performance of computational systems over time; and (3) Research on the acquisition, representation, and utilization of knowledge in support of diagnosis design of engineered systems and analysis of actual systems.

Basic stages in the development of the theory of Ramjet Engines (RJE)

NASA Technical Reports Server (NTRS)

Merkulov, I. A.

1977-01-01

Basic periods in the history of the development of ramjet engine theory are cited. The periods include the first experimental tests as well as the development of basic ideas and theoretical development of the cosmic ramjet engine.

Interactive learning media based on flash for basic electronic engineering development for SMK Negeri 1 Driyorejo - Gresik

NASA Astrophysics Data System (ADS)

Mandigo Anggana Raras, Gustav

2018-04-01

This research aims to produce a product in the form of flash based interactive learning media on a basic electronic engineering subject that reliable to be used and to know students’ responses about the media. The target of this research is X-TEI 1 class at SMK Negeri 1 Driyorejo – Gresik. The method used in this study is R&D that has been limited into seven stages only (1) potential and problems, (2) data collection, (3) product design, (4) product validation, (5) product revision, (6) field test, and (7) analysis and writing. The obtained result is interactive learning media named MELDASH. Validation process used to produce a valid interactive learning media. The result of media validation state that the interactive learning media has a 90.83% rating. Students’ responses to this interactive learning media is really good with 88.89% rating.

Integration of Behaviour-Based Safety Programme into Engineering Laboratories and Workshops Conceptually

ERIC Educational Resources Information Center

Koo, Kean Eng; Zain, Ahmad Nurulazam Md; Zainal, Siti Rohaida Mohamed

2012-01-01

The purpose of this conceptual research framework is to develop and integrate a safety training model using a behaviour-based safety training programme into laboratories for young adults, during their tertiary education, particularly in technical and vocational education. Hence, this research will be investigating the outcome of basic safety…

Derivation of Performance Statements for the Automotive Mechanics Basic Trade Course: Research Documentation.

ERIC Educational Resources Information Center

Fox, A. P.; Kuhl, D. H.

A project was conducted to derive a comprehensive list of the performances of a competence mechanic to satisfy the planning needs of automotive engineering lecturers, curriculum committees, researchers, course designers, and staff developers. A list of 127 tasks together with information about their relative importance and the frequency with which…

Operation of the Institute for Computer Applications in Science and Engineering

NASA Technical Reports Server (NTRS)

1975-01-01

The ICASE research program is described in detail; it consists of four major categories: (1) efficient use of vector and parallel computers, with particular emphasis on the CDC STAR-100; (2) numerical analysis, with particular emphasis on the development and analysis of basic numerical algorithms; (3) analysis and planning of large-scale software systems; and (4) computational research in engineering and the natural sciences, with particular emphasis on fluid dynamics. The work in each of these areas is described in detail; other activities are discussed, a prognosis of future activities are included.

Research requirements to reduce civil helicopter life cycle cost

NASA Technical Reports Server (NTRS)

Blewitt, S. J.

1978-01-01

The problem of the high cost of helicopter development, production, operation, and maintenance is defined and the cost drivers are identified. Helicopter life cycle costs would decrease by about 17 percent if currently available technology were applied. With advanced technology, a reduction of about 30 percent in helicopter life cycle costs is projected. Technological and managerial deficiencies which contribute to high costs are examined, basic research and development projects which can reduce costs include methods for reduced fuel consumption; improved turbine engines; airframe and engine production methods; safety; rotor systems; and advanced transmission systems.

Basic research on machinery fault diagnostics: Past, present, and future trends

NASA Astrophysics Data System (ADS)

Chen, Xuefeng; Wang, Shibin; Qiao, Baijie; Chen, Qiang

2018-06-01

Machinery fault diagnosis has progressed over the past decades with the evolution of machineries in terms of complexity and scale. High-value machineries require condition monitoring and fault diagnosis to guarantee their designed functions and performance throughout their lifetime. Research on machinery Fault diagnostics has grown rapidly in recent years. This paper attempts to summarize and review the recent R&D trends in the basic research field of machinery fault diagnosis in terms of four main aspects: Fault mechanism, sensor technique and signal acquisition, signal processing, and intelligent diagnostics. The review discusses the special contributions of Chinese scholars to machinery fault diagnostics. On the basis of the review of basic theory of machinery fault diagnosis and its practical applications in engineering, the paper concludes with a brief discussion on the future trends and challenges in machinery fault diagnosis.

Model Driven Engineering

NASA Astrophysics Data System (ADS)

Gaševic, Dragan; Djuric, Dragan; Devedžic, Vladan

A relevant initiative from the software engineering community called Model Driven Engineering (MDE) is being developed in parallel with the Semantic Web (Mellor et al. 2003a). The MDE approach to software development suggests that one should first develop a model of the system under study, which is then transformed into the real thing (i.e., an executable software entity). The most important research initiative in this area is the Model Driven Architecture (MDA), which is Model Driven Architecture being developed under the umbrella of the Object Management Group (OMG). This chapter describes the basic concepts of this software engineering effort.

Ignition study of a petrol/CNG single cylinder engine

NASA Astrophysics Data System (ADS)

Khan, N.; Saleem, Z.; Mirza, A. A.

2005-11-01

Benefits of laser ignition over the electrical ignition system for Compressed Natural Gas (CNG) engines have fuelled automobile industry and led to an extensive research on basic characteristics to switch over to the emerging technologies. This study was undertaken to determine the electrical and physical characteristics of the electric spark ignition of single cylinder petrol/CNG engine to determine minimum ignition requirements and timeline of ignition events to use in subsequent laser ignition study. This communication briefly reviews the ongoing research activities and reports the results of this experimental study. The premixed petrol and CNG mixtures were tested for variation of current and voltage characteristics of the spark with speed of engine. The current magnitude of discharge circuit was found to vary linearly over a wide range of speed but the stroke to stroke fire time was found to vary nonlinearly. The DC voltage profiles were observed to fluctuate randomly during ignition process and staying constant in rest of the combustion cycle. Fire to fire peaks of current amplitudes fluctuated up to 10% of the peak values at constant speed but increased almost linearly with increase in speed. Technical barriers of laser ignition related to threshold minimum ignition energy, inter-pulse durations and firing sequence are discussed. Present findings provide a basic initiative and background information for designing suitable timeline algorithms for laser ignited leaner direct injected CNG engines.

Expanding the Scope of Site-Specific Recombinases for Genetic and Metabolic Engineering

PubMed Central

Gaj, Thomas; Sirk, Shannon J.; Barbas, Carlos F.

2014-01-01

Site-specific recombinases are tremendously valuable tools for basic research and genetic engineering. By promoting high-fidelity DNA modifications, site-specific recombination systems have empowered researchers with unprecedented control over diverse biological functions, enabling countless insights into cellular structure and function. The rigid target specificities of many sites-specific recombinases, however, have limited their adoption in fields that require highly flexible recognition abilities. As a result, intense effort has been directed toward altering the properties of site-specific recombination systems by protein engineering. Here, we review key developments in the rational design and directed molecular evolution of site-specific recombinases, highlighting the numerous applications of these enzymes across diverse fields of study. PMID:23982993

National Aeronautics and Space Administration (NASA)/American Society for Engineering Education (ASEE) Summer Faculty Fellowship Program, 1987, volume 2

NASA Technical Reports Server (NTRS)

Jones, William B., Jr. (Editor); Goldstein, Stanley H. (Editor)

1987-01-01

The 1987 Johnson Space Center (JCS) National Aeronautics and Space Administration (NASA)/American Society for Engineering Education (ASEE) Summer Faculty Fellowship program was conducted by Texas A and M University and JSC. The 10-week program was operated under the auspices of ASEE. The basic objectives of the program are: to further the professional knowledge of qualified engineering and science faculty members; to stimulate an exchange of ideas between participants and NASA; to enrich and refresh the research and teaching activities of participants' institutions; and to contribute to the research objective of the NASA Centers. This document is a compilation of the final reports on the research projects done by the faculty fellows during the summer of 1987.

Researcher Poses with a Nuclear Rocket Model

NASA Image and Video Library

1961-11-21

A researcher at the NASA Lewis Research Center with slide ruler poses with models of the earth and a nuclear-propelled rocket. The Nuclear Engine for Rocket Vehicle Applications (NERVA) was a joint NASA and Atomic Energy Commission (AEC) endeavor to develop a nuclear-powered rocket for both long-range missions to Mars and as a possible upper-stage for the Apollo Program. The early portion of the program consisted of basic reactor and fuel system research. This was followed by a series of Kiwi reactors built to test nuclear rocket principles in a non-flying nuclear engine. The next phase, NERVA, would create an entire flyable engine. The AEC was responsible for designing the nuclear reactor and overall engine. NASA Lewis was responsible for developing the liquid-hydrogen fuel system. The nuclear rocket model in this photograph includes a reactor at the far right with a hydrogen propellant tank and large radiator below. The payload or crew would be at the far left, distanced from the reactor.

40 CFR 86.085-37 - Production vehicles and engines.

Code of Federal Regulations, 2014 CFR

2014-07-01

... transmission class. (2) Base level means a unique combination of basic engine, inertia weight, and transmission class. (3) Vehicle configuration means a unique combination of basic engine, engine code, inertia weight...

Guidelines for the use of visualization

DOT National Transportation Integrated Search

1998-12-01

This document is the product of a research project into visualization in the design and public review of transportation facilities. The project's goal was to provide NCDOT engineers and managers with a basic primer on this relatively new technology i...

Proceedings of the Conference on Graduate Student Research in Engineering and Technology Education (Minneapolis, Minnesota, May 22, 2008)

ERIC Educational Resources Information Center

National Center for Engineering and Technology Education, 2008

2008-01-01

As part of the usual end of year meeting that has been a feature of the National Center for Engineering and Technology Education (NCETE) project, a conference intending to provide a forum for young voices in an outside of the Center was organized. The basic model for the gathering was borrowed from track and field. This was to be an intellectual…

FY 1984 Science Budget overview

NASA Astrophysics Data System (ADS)

Astronomy, engineering, and the physical sciences as a whole were among the best funded programs in the fiscal 1984 budget that President Ronald Reagan sent to Congress last week. In addition, science education got a shot in the arm: The Reagan proposal includes plans for the nation's universities to upgrade scientific instrumentation and to attract and support high caliber scientists and engineers.Reagan proposes that federal funding for research and development, including R&D facilities, total $47 billion in fiscal 1984, up 17% from the fiscal 1983 level. Defense research and development programs would be increased 29%; nondefense R&D would be increased 0.4%. Total basic research would be boosted 10%.

FY10 Engineering Innovations, Research and Technology Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lane, M A; Aceves, S M; Paulson, C N

This report summarizes key research, development, and technology advancements in Lawrence Livermore National Laboratory's Engineering Directorate for FY2010. These efforts exemplify Engineering's nearly 60-year history of developing and applying the technology innovations needed for the Laboratory's national security missions, and embody Engineering's mission to ''Enable program success today and ensure the Laboratory's vitality tomorrow.'' Leading off the report is a section featuring compelling engineering innovations. These innovations range from advanced hydrogen storage that enables clean vehicles, to new nuclear material detection technologies, to a landmine detection system using ultra-wideband ground-penetrating radar. Many have been recognized with R&D Magazine's prestigious R&Dmore » 100 Award; all are examples of the forward-looking application of innovative engineering to pressing national problems and challenging customer requirements. Engineering's capability development strategy includes both fundamental research and technology development. Engineering research creates the competencies of the future where discovery-class groundwork is required. Our technology development (or reduction to practice) efforts enable many of the research breakthroughs across the Laboratory to translate from the world of basic research to the national security missions of the Laboratory. This portfolio approach produces new and advanced technological capabilities, and is a unique component of the value proposition of the Lawrence Livermore Laboratory. The balance of the report highlights this work in research and technology, organized into thematic technical areas: Computational Engineering; Micro/Nano-Devices and Structures; Measurement Technologies; Engineering Systems for Knowledge Discovery; and Energy Manipulation. Our investments in these areas serve not only known programmatic requirements of today and tomorrow, but also anticipate the breakthrough engineering innovations that will be needed in the future.« less

Business Process Reengineering in the Inventory Management to Improve Aircraft Maintenance Operations in the Indonesian Air Force

DTIC Science & Technology

2006-06-01

research will cover an overview of business process engineering (BPR) and operation management . The focus will be on the basic process of BPR, inventory...management and improvement of the process of business operation management to appropriately provide a basic model for the Indonesian Air Force in...discuss the operation management aspects of inventory management and process improvement, including Economic Order Quantity, Material Requirement

Demand for interdisciplinary laboratories for physiology research by undergraduate students in biosciences and biomedical engineering.

PubMed

Clase, Kari L; Hein, Patrick W; Pelaez, Nancy J

2008-12-01

Physiology as a discipline is uniquely positioned to engage undergraduate students in interdisciplinary research in response to the 2006-2011 National Science Foundation Strategic Plan call for innovative transformational research, which emphasizes multidisciplinary projects. To prepare undergraduates for careers that cross disciplinary boundaries, students need to practice interdisciplinary communication in academic programs that connect students in diverse disciplines. This report surveys policy documents relevant to this emphasis on interdisciplinary training and suggests a changing role for physiology courses in bioscience and engineering programs. A role for a physiology course is increasingly recommended for engineering programs, but the study of physiology from an engineering perspective might differ from the study of physiology as a basic science. Indeed, physiology laboratory courses provide an arena where biomedical engineering and bioscience students can apply knowledge from both fields while cooperating in multidisciplinary teams under specified technical constraints. Because different problem-solving approaches are used by students of engineering and bioscience, instructional innovations are needed to break down stereotypes between the disciplines and create an educational environment where interdisciplinary teamwork is used to bridge differences.

Clinical research: business opportunities for pharmacy-based investigational drug services.

PubMed

Marnocha, R M

1999-02-01

The application by an academic health center of business principles to the conduct of clinical research is described. Re-engineering of the infrastructure for clinical research at the University of Wisconsin and University of Wisconsin Hospital and Clinics began in 1990 with the creation of the Center for Clinical Trials (CCT) and the restructuring of the investigational drug services (IDS). Strategies to further improve the institution's clinical research activities have been continually assessed and most recently have centered on the adaptation of a business philosophy within the institution's multidisciplinary research infrastructure. Toward that end, the CCT and IDS have introduced basic business principles into operational activities. Four basic business concepts have been implemented: viewing the research protocol as a commodity, seeking payment for services rendered, tracking investments, and assessing performance. It is proposed that incorporation of these basic business concepts is not only compatible with the infrastructure for clinical research but beneficial to that infrastructure. The adaptation of a business mindset is likely to enable an academic health center to reach its clinical research goals.

Data Fusion for Enhanced Aircraft Engine Prognostics and Health Management

NASA Technical Reports Server (NTRS)

Volponi, Al

2005-01-01

Aircraft gas-turbine engine data is available from a variety of sources, including on-board sensor measurements, maintenance histories, and component models. An ultimate goal of Propulsion Health Management (PHM) is to maximize the amount of meaningful information that can be extracted from disparate data sources to obtain comprehensive diagnostic and prognostic knowledge regarding the health of the engine. Data fusion is the integration of data or information from multiple sources for the achievement of improved accuracy and more specific inferences than can be obtained from the use of a single sensor alone. The basic tenet underlying the data/ information fusion concept is to leverage all available information to enhance diagnostic visibility, increase diagnostic reliability and reduce the number of diagnostic false alarms. This report describes a basic PHM data fusion architecture being developed in alignment with the NASA C-17 PHM Flight Test program. The challenge of how to maximize the meaningful information extracted from disparate data sources to obtain enhanced diagnostic and prognostic information regarding the health and condition of the engine is the primary goal of this endeavor. To address this challenge, NASA Glenn Research Center, NASA Dryden Flight Research Center, and Pratt & Whitney have formed a team with several small innovative technology companies to plan and conduct a research project in the area of data fusion, as it applies to PHM. Methodologies being developed and evaluated have been drawn from a wide range of areas including artificial intelligence, pattern recognition, statistical estimation, and fuzzy logic. This report will provide a chronology and summary of the work accomplished under this research contract.

Overcoming obstacles to implementation: addressing political, institutional and behavioral problems in earthquake hazard mitigation policies

NASA Astrophysics Data System (ADS)

Alesch, Daniel J.; Petak, William J.

2002-06-01

This project is aimed at bridging the three planes, from basic research, through enabling processes, to engineered systems. At the basic research plane, we have been working to improve our collective understanding about obstacles to implementing mitigation practices, owner decision processes (in connection with other MCEER projects), and public policy processes. At the level of enabling processes, we have been seeking to develop an understanding of how obstacles to greater mitigation can be overcome by improved policy design and processes. At the engineered systems plane, our work is intended to result in practical guidelines for devising policies and programs with appropriate motivation and incentives for implementing policies and programs once adopted. This phase of the research has been aimed, first, at a thorough, multidisciplinary review of the literature concerning obstacles to implementation. Second, the research has focused on advancing the state of the art by developing means for integrating the insights offered by diverse perspectives on the implementation process from the several social, behavioral, and decision sciences. The research establishes a basis for testing our understanding of these processes in the case of hospital retrofit decisions.

An overview of NASA intermittent combustion engine research

NASA Technical Reports Server (NTRS)

Willis, E. A.; Wintucky, W. T.

1984-01-01

This paper overviews the current program, whose objective is to establish the generic technology base for advanced aircraft I.C. engines of the early 1990's and beyond. The major emphasis of this paper is on development of the past two years. Past studies and ongoing confirmatory experimental efforts are reviewed, which show unexpectedly high potential when modern aerospace technologies are applied to inherently compact and balanced I.C. engine configurations. Currently, the program is focussed on two engine concepts, the stratified-charge, multi-fuel rotary and the lightweight two-stroke diesel. A review is given of contracted and planned high performance one-rotor and one-cylinder test engine work addressing several levels of technology. Also reviewed are basic supporting efforts, e.g., the development and experimental validation of computerized airflow and combustion process models, being performed in-house at Lewis Research Center and by university grants. Previously announced in STAR as N84-24583

An overview of NASA intermittent combustion engine research

NASA Technical Reports Server (NTRS)

Willis, E. A.; Wintucky, W. T.

1984-01-01

This paper overviews the current program, whose objective is to establish the generic technology base for advanced aircraft I.C. engines of the early 1990's and beyond. The major emphasis of this paper is on development of the past two years. Past studies and ongoing confirmatory experimental efforts are reviewed, which show unexpectly high potential when modern aerospace technologies are applied to inherently compact and balanced I.C. engine configurations. Currently, the program is focussed on two engine concepts the stratified-charge, multi-fuel rotary, and the lightweight two-stroke diesel. A review is given of contracted and planned high performance one-rotor and one-cylinder test engine work addressing several levels of technology. Also reviewed are basic supporting efforts, e.g., the development and experimental validation of computerized airflow and combustion process models, being performed in-house at Lewis Research Center and by university grants.

Recent Cooperative Research Activities of HDD and Flexible Media Transport Technologies in Japan

NASA Astrophysics Data System (ADS)

Ono, Kyosuke

This paper presents the recent status of industry-university cooperative research activities in Japan on the mechatronics of information storage and input/output equipment. There are three research committees for promoting information exchange on technical problems and research topics of head-disk interface in hard disk drives (HDD), flexible media transport and image printing processes which are supported by the Japan Society of Mechanical Engineering (JSME), the Japanese Society of Tribologists (JAST) and the Japan Society of Precision Engineering (JSPE). For hard disk drive technology, the Storage Research Consortium (SRC) is supporting more than 40 research groups in various different universities to perform basic research for future HDD technology. The past and present statuses of these activities are introduced, particularly focusing on HDD and flexible media transport mechanisms.

Overview of NASA Lewis Research Center free-piston Stirling engine technology activities applicable to space power systems

NASA Technical Reports Server (NTRS)

Slaby, Jack G.

1987-01-01

A brief overview is presented of the development and technological activities of the free-piston Stirling engine. The engine started as a small scale fractional horsepower engine which demonstrated basic engine operating principles and the advantages of being hermetically sealed, highly efficient, and simple. It eventually developed into the free piston Stirling engine driven heat pump, and then into the SP-100 Space Reactor Power Program from which came the Space Power Demonstrator Engine (SPDE). The SPDE successfully operated for over 300 hr and delivered 20 kW of PV power to an alternator plunger. The SPDE demonstrated that a dynamic power conversion system can, with proper design, be balanced; and the engine performed well with externally pumped hydrostatic gas bearings.

Early Program Development

NASA Image and Video Library

1961-01-01

As presented by Gerhard Heller of Marshall Space Flight Center's Research Projects Division in 1961, this chart illustrates three basic types of electric propulsion systems then under consideration by NASA. The ion engine (top) utilized cesium atoms ionized by hot tungsten and accelerated by an electrostatic field to produce thrust. The arc engine (middle) achieved propulsion by heating a propellant with an electric arc and then producing an expansion of the hot gas or plasma in a convergent-divergent duct. The electromagnetic, or MFD engine (bottom) manipulated strong magnetic fields to interact with a plasma and produce acceleration.

Rocket propulsion research at Lewis Research Center

NASA Technical Reports Server (NTRS)

Dawson, Virginia P.

1992-01-01

A small contingent of engineers at NASA LeRC pioneered the basic research on liquid propellants for rockets shortly after World War 2. Carried on through the 1950s, this work influenced the important early decisions made by Abe Silverstein when he took charge of the Office of Space Flight Programs for NASA. He strongly supported the development of liquid hydrogen as a propulsion fuel in the face of resistance from Wernher von Braun. Members of the LeRC staff played an important role in bringing liquid hydrogen technology to the point of reliability through their management of the Centaur Program. This paper demonstrates how the personality and engineering intuition of Abe Silverstein shaped the Centaur program and left a lasting imprint on the laboratory research tradition. Many of the current leaders of LeRC received their first hands-on engineering experience when they worked on the Centaur program in the 1960s.

T/BEST: Technology Benefit Estimator for Composites and Applications to Engine Structures

NASA Technical Reports Server (NTRS)

Chamis, Christos

1997-01-01

Progress in the field of aerospace propulsion has heightened the need to combine advanced technologies. These benefits will provide guidelines for identifying and prioritizing high-payoff research areas, will help manage research with limited resources, and will show the link between advanced and basic concepts. An effort was undertaken at the NASA Lewis Research Center to develop a formal computational method, T/BEST (Technology Benefit Estimator), to assess advanced aerospace technologies, such as fibrous composites, and credibly communicate the benefits of research. Fibrous composites are ideal for structural applications such as high-performance aircraft engine blades where high strength-to-weight and stiffness-to-weight ratios are required. These factors - along with the flexibility to select the composite system and layup, and to favorably orient fiber directions - reduce the displacements and stresses caused by large rotational speeds in aircraft engines.

National Aeronautics and Space Administration (NASA)/American Society for Engineering Education (ASEE) summer faculty fellowship program, 1986, volume 2

NASA Technical Reports Server (NTRS)

Mcinnis, Bayliss (Editor); Goldstein, Stanley (Editor)

1987-01-01

The Johnson Space Center (JSC) NASA/ASEE Summer Faculty Fellowship Program was conducted by the University of Houston and JSC. The ten week program was operated under the auspices of the American Society for Engineering Education (ASEE). The basic objectives of the program are (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of participants' institutions; and (4) to contribute to the research objectives of the NASA Centers. Each faculty fellow spent ten weeks at JSC engaged in a research project commensurate with his interests and background and worked in collaboration with a NASA/JSC colleague. The final reports on the research projects are presented. This volume, 2, contains sections 15 through 30.

The FCC: A Research Tool.

ERIC Educational Resources Information Center

Wilson, Paul

The numerous forms filed with the Federal Communications Commission (FCC) provide information about a variety of topics. Basic licensing information that is available concerns engineering, ownership, and equal employment opportunity. The FCC's broadcast bureau collects information about programing, the ascertainment of community needs, public…

Standardized Curriculum for Diesel Engine Mechanics.

ERIC Educational Resources Information Center

Mississippi State Dept. of Education, Jackson. Office of Vocational, Technical and Adult Education.

Standardized curricula are provided for two courses for the secondary vocational education program in Mississippi: diesel engine mechanics I and II. The eight units in diesel engine mechanics I are as follows: orientation; shop safety; basic shop tools; fasteners; measurement; engine operating principles; engine components; and basic auxiliary…

Center for Space Construction

NASA Technical Reports Server (NTRS)

Su, Renjeng

1998-01-01

The Center for Space Construction (CSC) at University of Colorado at Boulder is one of eight University Space Engineering Research Centers established by NASA in 1988. The mission of the Center is to conduct research into space technology and to directly contribute to space engineering education. The Center reports to the Department of Aerospace Engineering Sciences and resides in the College of Engineering and Applied Sciences. The College has a long and successful track record of cultivating multi-disciplinary research and education programs. The Center for Space Construction represents prominent evidence of this record. The basic concept on which the Center was founded is the in-space construction of large space systems, such as space stations, interplanetary space vehicles, and extraterrestrial space structures. Since 1993, the scope of CSC research has evolved to include the design and construction of all spacecraft, large and small. With the broadened scope our research projects seek to impact the technological basis for spacecraft such as remote sensing satellites, communication satellites and other special-purpose spacecraft, as well as large space platforms. A summary of accomplishments, including student participation and degrees awarded, during the contract period is presented.

M.U.S.T. 2007 Summer Research Project at NASA's KSC MILA Facility

NASA Technical Reports Server (NTRS)

PintoRey, Christian R.

2007-01-01

The summer research activity at Kennedy Space Center (KSC) aims to introduce the student to the basic principles in their field of study. While at KSC, a specific research project awaits the student to complete. As an Aeronautical Engineering student, my assigned project is to assist the cognizant engineer, Mr. Troy Hamilton, in the six engineering phases for replacing the Ponce De Leon (PDL)4.3M Antenna Control Unit (ACU). Although the project mainly requires the attention of two engineers and two students, it also involves the participation of many colleagues at various points during the course of the engineering change (EC). Since the PDL 4.3M ACU engineering change makes both hardware and software changes, it calls upon the expertise of a Hardware Engineer as well as a Software Engineer. As students, Mr. Jeremy Bresette and I have worked side by side with the engineers, gaining invaluable experience. We work in two teams, the hardware team and the software team, On certain tasks, we assist the engineers, while on others we assume their roles. By diligently working in this fashion, we are learning how to communicate effectively as professionals, despite the fact that we are studying different engineering fields. This project has been a great fit for my field of study, as it has highly improved my awareness of the many critical tasks involved in carrying out an engineering project.

Small Engine Repair. Two-Stroke and Four-Stroke Cycle.

ERIC Educational Resources Information Center

Hires, Bill; And Others

This curriculum guide is intended to assist persons teaching a course in repairing two- and four-stroke cycle small engines. Addressed in the individual units of instruction are the following topics: safety, tools, fasteners, and measurement techniques; basic small engine theory (engine identification and inspection, basic engine principles and…

Chemical Research Projects Office: Functions, accomplishments, and programs

NASA Technical Reports Server (NTRS)

Kourtides, D. A.; Parker, J. A.

1972-01-01

The purpose, technical accomplishments, and related activities of the Chemical Research Project Group are outlined. Data cover efforts made to: (1) identify chemical research and technology required for solutions to problems of national urgency, synchronous with aeronautics and space effort; (2) conduct basic and applied interdisciplinary research on chemical problems in the areas of macromolecular science and fire research, and (3) provide productive liason with the engineering community and effective transfer of technology to other agencies and industry.

Multidimensional computer simulation of Stirling cycle engines

NASA Technical Reports Server (NTRS)

Hall, C. A.; Porsching, T. A.; Medley, J.; Tew, R. C.

1990-01-01

The computer code ALGAE (algorithms for the gas equations) treats incompressible, thermally expandable, or locally compressible flows in complicated two-dimensional flow regions. The solution method, finite differencing schemes, and basic modeling of the field equations in ALGAE are applicable to engineering design settings of the type found in Stirling cycle engines. The use of ALGAE to model multiple components of the space power research engine (SPRE) is reported. Videotape computer simulations of the transient behavior of the working gas (helium) in the heater-regenerator-cooler complex of the SPRE demonstrate the usefulness of such a program in providing information on thermal and hydraulic phenomena in multiple component sections of the SPRE.

Research on reform plan of civil engineering adult education graduation design

NASA Astrophysics Data System (ADS)

Su, Zhibin; Sun, Shengnan; Cui, Shicai

2017-12-01

As for civil engineering adult education graduation design, reform program is put forward combined with our school. The main points of reform include the following aspects. New pattern of graduation design which is consisted of basic training of engineering design, technical application and engineering innovation training is formed. Integration model of graduation design and employment is carried out. Multiple professional guidance graduation design pattern is put forward. Subject of graduation design is chosen based on the school actual circumstance. A “three stage” quality monitoring system is established. Performance evaluation pattern that concludes two oral examinations of the dissertation is strictly carried out.

Engineering Data Compendium. Human Perception and Performance, Volume 1

NASA Technical Reports Server (NTRS)

Boff, Kenneth R. (Editor); Lincoln, Janet E. (Editor)

1988-01-01

The concept underlying the Engineering Data Compendium was the product an R and D program (Integrated Perceptual Information for Designers project) aimed at facilitating the application of basic research findings in human performance to the design of military crew systems. The principal objective was to develop a workable strategy for: (1) identifying and distilling information of potential value to system design from existing research literature, and (2) presenting this technical information in a way that would aid its accessibility, interpretability, and applicability by system designers. The present four volumes of the Engineering Data Compendium represent the first implementation of this strategy. This is Volume 1, which contains sections on Visual Acquisition of Information, Auditory Acquisition of Information, and Acquisition of Information by Other Senses.

Expanding the scope of site-specific recombinases for genetic and metabolic engineering.

PubMed

Gaj, Thomas; Sirk, Shannon J; Barbas, Carlos F

2014-01-01

Site-specific recombinases are tremendously valuable tools for basic research and genetic engineering. By promoting high-fidelity DNA modifications, site-specific recombination systems have empowered researchers with unprecedented control over diverse biological functions, enabling countless insights into cellular structure and function. The rigid target specificities of many sites-specific recombinases, however, have limited their adoption in fields that require highly flexible recognition abilities. As a result, intense effort has been directed toward altering the properties of site-specific recombination systems by protein engineering. Here, we review key developments in the rational design and directed molecular evolution of site-specific recombinases, highlighting the numerous applications of these enzymes across diverse fields of study. © 2013 Wiley Periodicals, Inc.

NASA Propulsion Engineering Research Center, volume 1

NASA Technical Reports Server (NTRS)

1993-01-01

Over the past year, the Propulsion Engineering Research Center at The Pennsylvania State University continued its progress toward meeting the goals of NASA's University Space Engineering Research Centers (USERC) program. The USERC program was initiated in 1988 by the Office of Aeronautics and Space Technology to provide an invigorating force to drive technology advancements in the U.S. space industry. The Propulsion Center's role in this effort is to provide a fundamental basis from which the technology advances in propulsion can be derived. To fulfill this role, an integrated program was developed that focuses research efforts on key technical areas, provides students with a broad education in traditional propulsion-related science and engineering disciplines, and provides minority and other under-represented students with opportunities to take their first step toward professional careers in propulsion engineering. The program is made efficient by incorporating government propulsion laboratories and the U.S. propulsion industry into the program through extensive interactions and research involvement. The Center is comprised of faculty, professional staff, and graduate and undergraduate students working on a broad spectrum of research issues related to propulsion. The Center's research focus encompasses both current and advanced propulsion concepts for space transportation, with a research emphasis on liquid propellant rocket engines. The liquid rocket engine research includes programs in combustion and turbomachinery. Other space transportation modes that are being addressed include anti-matter, electric, nuclear, and solid propellant propulsion. Outside funding supports a significant fraction of Center research, with the major portion of the basic USERC grant being used for graduate student support and recruitment. The remainder of the USERC funds are used to support programs to increase minority student enrollment in engineering, to maintain Center infrastructure, and to develop research capability in key new areas. Significant research programs in propulsion systems for air and land transportation complement the space propulsion focus. The primary mission of the Center is student education. The student program emphasizes formal class work and research in classical engineering and science disciplines with applications to propulsion.

23 CFR 655.604 - Achieving basic uniformity.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS TRAFFIC OPERATIONS Traffic Control Devices on Federal-Aid and Other Streets and Highways § 655.604... the Highway Safety Program Guideline 21, “Roadway Safety.” Highway planning and research funds and...

23 CFR 655.604 - Achieving basic uniformity.

Code of Federal Regulations, 2011 CFR

2011-04-01

... Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS TRAFFIC OPERATIONS Traffic Control Devices on Federal-Aid and Other Streets and Highways § 655.604... the Highway Safety Program Guideline 21, “Roadway Safety.” Highway planning and research funds and...

General Motors and the University of Michigan smart materials and structures collaborative research laboratory

NASA Astrophysics Data System (ADS)

Brei, Diann; Luntz, Jonathan; Shaw, John; Johnson, Nancy L.; Browne, Alan L.; Alexander, Paul W.; Mankame, Nilesh D.

2007-04-01

The field of Smart Materials and Structures is evolving from high-end, one-of-a-kind products for medical, military and aerospace applications to the point of viability for mainstream affordable high volume products for automotive applications. For the automotive industry, there are significant potential benefits to be realized including reduction in vehicle mass, added functionality and design flexibility and decrease in component size and cost. To further accelerate the path from basic research and development to launched competitive products, General Motors (GM) has teamed with the College of Engineering at the University of Michigan (UM) to establish a $2.9 Million Collaborative Research Laboratory (CRL) in Smart Materials and Structures. Researchers at both GM and UM are working closely together to create leap-frog technologies which start at conceptualization and proceed all the way through demonstration and handoff to product teams, thereby bridging the traditional technology gap between industry and academia. In addition to Smart Device Technology Innovation, other thrust areas in the CRL include Smart Material Maturity with a basic research focus on overcoming material issues that form roadblocks to commercialism and Mechamatronic System Design Methodology with an applied focus on development tools (synthesis and analysis) to aid the engineer in application of smart materials to system engineering. This CRL is a global effort with partners across the nation and world from GM's Global Research Network such as HRL Laboratories in California and GM's India Science Lab in Bangalore, India. This paper provides an overview of this new CRL and gives examples of several of the projects underway.

Air Force Office of Scientific Research, 1993 Research Highlights.

DTIC Science & Technology

1993-01-01

used to describe the behavior of critical point phenomena by Nobel laureate Dr. Kenneth Wilson. Their research has produced useful engineering...40 years of its existence, AFOSR has supported the work of about two dozen scientists who, later, have been awarded the Nobel prize as well as a...locations and types of sensor or actuator elements that are suitable for structurally- integrated nondestructive evaluation ( NDE ) systems. The basic

Integrating system safety into the basic systems engineering process

NASA Technical Reports Server (NTRS)

Griswold, J. W.

1971-01-01

The basic elements of a systems engineering process are given along with a detailed description of what the safety system requires from the systems engineering process. Also discussed is the safety that the system provides to other subfunctions of systems engineering.

Test Stand at the Rocket Engine Test Facility

NASA Image and Video Library

1973-02-21

The thrust stand in the Rocket Engine Test Facility at the National Aeronautics and Space Administration (NASA) Lewis Research Center in Cleveland, Ohio. The Rocket Engine Test Facility was constructed in the mid-1950s to expand upon the smaller test cells built a decade before at the Rocket Laboratory. The $2.5-million Rocket Engine Test Facility could test larger hydrogen-fluorine and hydrogen-oxygen rocket thrust chambers with thrust levels up to 20,000 pounds. Test Stand A, seen in this photograph, was designed to fire vertically mounted rocket engines downward. The exhaust passed through an exhaust gas scrubber and muffler before being vented into the atmosphere. Lewis researchers in the early 1970s used the Rocket Engine Test Facility to perform basic research that could be utilized by designers of the Space Shuttle Main Engines. A new electronic ignition system and timer were installed at the facility for these tests. Lewis researchers demonstrated the benefits of ceramic thermal coatings for the engine’s thrust chamber and determined the optimal composite material for the coatings. They compared the thermal-coated thrust chamber to traditional unlined high-temperature thrust chambers. There were more than 17,000 different configurations tested on this stand between 1973 and 1976. The Rocket Engine Test Facility was later designated a National Historic Landmark for its role in the development of liquid hydrogen as a propellant.

The Impact of "Coat Protein-Mediated Virus Resistance" in Applied Plant Pathology and Basic Research.

PubMed

Lindbo, John A; Falk, Bryce W

2017-06-01

Worldwide, plant viruses cause serious reductions in marketable crop yield and in some cases even plant death. In most cases, the most effective way to control virus diseases is through genetically controlled resistance. However, developing virus-resistant (VR) crops through traditional breeding can take many years, and in some cases is not even possible. Because of this, the demonstration of the first VR transgenic plants in 1985 generated much attention. This seminal report served as an inflection point for research in both basic and applied plant pathology, the results of which have dramatically changed both basic research and in a few cases, commercial crop production. The typical review article on this topic has focused on only basic or only applied research results stemming from this seminal discovery. This can make it difficult for the reader to appreciate the full impact of research on transgenic virus resistance, and the contributions from fundamental research that led to translational applications of this technology. In this review, we take a global view of this topic highlighting the significant changes to both basic and applied plant pathology research and commercial food production that have accumulated in the last 30 plus years. We present these milestones in the historical context of some of the scientific, economic, and environmental drivers for developing specific VR crops. The intent of this review is to provide a single document that adequately records the significant accomplishments of researchers in both basic and applied plant pathology research on this topic and how they relate to each other. We hope this review therefore serves as both an instructional tool for students new to the topic, as well as a source of conversation and discussion for how the technology of engineered virus resistance could be applied in the future.

Activities for the Promotion of Gender Equality in Japan—Physical Society of Japan

NASA Astrophysics Data System (ADS)

Agui, Akane; Tanida, Kiyoshi; Torikai, Eiko

2005-10-01

The Gender Equality Promotion Committee of the Physical Society of Japan (JPS) was established as a result of the First International IUPAP Conference on Women in Physics (Paris, 2002). It is a gender-balanced team of 12 full members and a group of net-commentators. The former chairperson of the committee, Masako Bando, was selected to be the president of JPS between September 2006 and August 2007. Based on the survey on the present status of the gender equality and the research environment of the JPS members in 2001, JPS advanced two recommendations to the governmental authorities, academic institutes, and organizations: for flexible childcare supports and for improved research granting systems for post-doctoral fellows and part-time researchers in August 2003. Now these activities have become nationwide with the establishment in October 2002 of the Japan Inter-Society Liaison Association Committee for Promoting Equal Participation of Men and Women in Science and Engineering (EPMEWSE). It has 44 member societies, including 19 observers, from various academic fields. An extended survey was carried out by EPMEWSE in November 2003; 20,000 respondents revealed diverse visions of scientists and engineers. These activities effectively help foster public understanding and awareness of the state of women in physics, especially among policy-making authorities. In 2005 the Cabinet is drawing up two Basic Plans for 2006-2010: the Science and Technology Basic Plan for the third term and the Basic Plan for the Gender-Equal Society for the second term. To attract girls into science and engineering, JPS is organizing the Girls Science Summer School to be held in August 2005 in collaboration with the National Women Education Center and EPMEWSE.

Summary of research in applied mathematics, numerical analysis, and computer sciences

NASA Technical Reports Server (NTRS)

1986-01-01

The major categories of current ICASE research programs addressed include: numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; control and parameter identification problems, with emphasis on effective numerical methods; computational problems in engineering and physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and computer systems and software, especially vector and parallel computers.

Chemical research projects office: An overview and bibliography, 1975-1980

NASA Technical Reports Server (NTRS)

Kourtides, D. A.; Heimbuch, A. H.; Parker, J. A.

1980-01-01

The activities of the Chemical Research Projects Office at Ames Research Center, Moffett Field, California are reported. The office conducts basic and applied research in the fields of polymer chemistry, computational chemistry, polymer physics, and physical and organic chemistry. It works to identify the chemical research and technology required for solutions to problems of national urgency, synchronous with the aeronautic and space effort. It conducts interdisciplinary research on chemical problems, mainly in areas of macromolecular science and fire research. The office also acts as liaison with the engineering community and assures that relevant technology is made available to other NASA centers, agencies, and industry. Recent accomplishments are listed in this report. Activities of the three research groups, Polymer Research, Aircraft Operating and Safety, and Engineering Testing, are summarized. A complete bibliography which lists all Chemical Research Projects Office publications, contracts, grants, patents, and presentations from 1975 to 1980 is included.

Conservation of strategic metals

NASA Technical Reports Server (NTRS)

Stephens, J. R.

1982-01-01

A long-range program in support of the aerospace industry aimed at reducing the use of strategic materials in gas turbine engines is discussed. The program, which is called COSAM (Conservation of Strategic Aerospace Materials), has three general objectives. The first objective is to contribute basic scientific understanding to the turbine engine technology bank so that our national security is not jeopardized if our strategic material supply lines are disrupted. The second objective is to help reduce the dependence of United States military and civilian gas turbine engines on worldwide supply and price fluctuations in regard to strategic materials. The third objective is, through research, to contribute to the United States position of preeminence in the world gas turbine engine markets by minimizing the acquisition costs and optimizing the performance of gas turbine engines. Three major research thrusts are planned: strategic element substitution; advanced processing concepts; and alternate material identification. Results from research and any required supporting technology will give industry the materials technology options it needs to make tradeoffs in material properties for critical components against the cost and availability impacts related to their strategic metal content.

NACA Mechanics in an Allison Engine Training Class

NASA Image and Video Library

1943-10-21

The Allison Engine Company's A.G. Covell instructs mechanics from various divisions at the National Advisory Committee for Aeronautics (NACA) Aircraft Engine Research Laboratory on the operation of the Allison Basic Engine. The military had asked that the laboratory undertake an extensive program to improve the performance of the Allison V–1710 engine. The V–1710 was the only liquid-cooled engine used during World War II, and the military counted on it to power several types of fighter aircraft. The NACA instituted an Apprentice Program during the war to educate future mechanics, technicians, and electricians. The program was suspended for a number of years due to the increasing rates of military service by its participants. The laboratory continued its in-house education during the war, however, by offering a number of classes to its employees and lectures for the research staff. The classes and lectures were usually taught by fellow members of the staff, but occasionally external experts were brought in. The students in the Allison class in the Engine Research Building were taught how to completely disassemble and reassemble the engine components and systems. From left to right are Don Vining, Ed Cudlin, Gus DiNovo, George Larsen, Charles Diggs, Martin Lipes, Harley Roberts, Martin Berwaldt and John Dempsey. A.G. Covell is standing.

Engineering Yarrowia lipolytica for Use in Biotechnological Applications: A Review of Major Achievements and Recent Innovations.

PubMed

Madzak, Catherine

2018-06-25

Yarrowia lipolytica is an oleaginous saccharomycetous yeast with a long history of industrial use. It aroused interest several decades ago as host for heterologous protein production. Thanks to the development of numerous molecular and genetic tools, Y. lipolytica is now a recognized system for expressing heterologous genes and secreting the corresponding proteins of interest. As genomic and transcriptomic tools increased our basic knowledge on this yeast, we can now envision engineering its metabolic pathways for use as whole-cell factory in various bioconversion processes. Y. lipolytica is currently being developed as a workhorse for biotechnology, notably for single-cell oil production and upgrading of industrial wastes into valuable products. As it becomes more and more difficult to keep up with an ever-increasing literature on Y. lipolytica engineering technology, this article aims to provide basic and actualized knowledge on this research area. The most useful reviews on Y. lipolytica biology, use, and safety will be evoked, together with a resume of the engineering tools available in this yeast. This mini-review will then focus on recently developed tools and engineering strategies, with a particular emphasis on promoter tuning, metabolic pathways assembly, and genome editing technologies.

Engineering excellence in breakthrough biomedical technologies: bioengineering at the University of California, Riverside.

PubMed

Schultz, Jane S; Rodgers, V G J

2012-07-01

The Department of Bioengineering at the University of California, Riverside (UCR), was established in 2006 and is the youngest department in the Bourns College of Engineering. It is an interdisciplinary research engine that builds strength from highly recognized experts in biochemistry, biophysics, biology, and engineering, focusing on common critical themes. The range of faculty research interests is notable for its diversity, from the basic cell biology through cell function to the physiology of the whole organism, each directed at breakthroughs in biomedical devices for measurement and therapy. The department forges future leaders in bioengineering, mirroring the field in being energetic, interdisciplinary, and fast moving at the frontiers of biomedical discoveries. Our educational programs combine a solid foundation in bio logical sciences and engineering, diverse communication skills, and training in the most advanced quantitative bioengineering research. Bioengineering at UCR also includes the Bioengineering Interdepartmental Graduate (BIG) program. With its slogan Start-Grow-Be-BIG, it is already recognized for its many accomplishments, including being third in the nation in 2011 for bioengineering students receiving National Science Foundation graduate research fellowships as well as being one of the most ethnically inclusive programs in the nation.

Cape Wind: A Public Policy Debate for the Physical Sciences

ERIC Educational Resources Information Center

Mayer, Shannon

2007-01-01

Since the industrial revolution, technological innovation and the application of basic scientific research have transformed society. Increasingly, critical conversations and legislation regarding national and international public policy have sophisticated scientific underpinnings. It is crucial that we prepare scientists and engineers with an…

Report of the Defense Science Board Task Force on Basic Research

DTIC Science & Technology

2012-01-01

Applied Research Navy $2.5 Laboratory University of Maryland, College Park: Center for National Security $18.7 Advanced Study of Language Agency ( NSA ...Stevens Institute of Technology: Systems ASD{R&E) and $7.2 Engineering Research Center NSA DOD Federally Funded Research and Development Centers...Navy USD(AT&L) Army USD(AT&L) Air Force Air Force USD(AT&L) NSA USD(AT&L) USD(AT&L) FFRDCs that are sponsored by agencies other than DOD

Microbiome Therapeutics – Advances and Challenges

PubMed Central

Mimee, Mark; Citorik, Robert J.; Lu, Timothy K.

2016-01-01

The microbial community that lives on and in the human body exerts a major impact on human health, from metabolism to immunity. In order to leverage the close associations between microbes and their host, development of therapeutics targeting the microbiota has surged in recent years. Here, we discuss current additive and subtractive strategies to manipulate the microbiota, focusing on bacteria engineered to produce therapeutic payloads, consortia of natural organisms and selective antimicrobials. Further, we present challenges faced by the community in the development of microbiome therapeutics, including designing microbial therapies that are adapted for specific geographies in the body, stable colonization with microbial therapies, discovery of clinically relevant biosensors, robustness of engineered synthetic gene circuits and addressing safety and biocontainment concerns. Moving forward, collaboration between basic and applied researchers and clinicians to address these challenges will poise the field to herald an age of next-generation, cellular therapies that draw on novel findings in basic research to inform directed augmentation of the human microbiota. PMID:27158095

Microbiome therapeutics - Advances and challenges.

PubMed

Mimee, Mark; Citorik, Robert J; Lu, Timothy K

2016-10-01

The microbial community that lives on and in the human body exerts a major impact on human health, from metabolism to immunity. In order to leverage the close associations between microbes and their host, development of therapeutics targeting the microbiota has surged in recent years. Here, we discuss current additive and subtractive strategies to manipulate the microbiota, focusing on bacteria engineered to produce therapeutic payloads, consortia of natural organisms and selective antimicrobials. Further, we present challenges faced by the community in the development of microbiome therapeutics, including designing microbial therapies that are adapted for specific geographies in the body, stable colonization with microbial therapies, discovery of clinically relevant biosensors, robustness of engineered synthetic gene circuits and addressing safety and biocontainment concerns. Moving forward, collaboration between basic and applied researchers and clinicians to address these challenges will poise the field to herald an age of next-generation, cellular therapies that draw on novel findings in basic research to inform directed augmentation of the human microbiota. Copyright © 2016. Published by Elsevier B.V.

A research project to develop and evaluate a technical education component on materials technology for orientation to space-age technology

NASA Technical Reports Server (NTRS)

Jacobs, J. A.

1976-01-01

A project was initiated to develop, implement, and evaluate a prototype component for self-pacing, individualized instruction on basic materials science. Results of this project indicate that systematically developed, self-paced instruction provides an effective means for orienting nontraditional college students and secondary students, especially minorities, to both engineering technology and basic materials science. In addition, students using such a system gain greater chances for mastering subject matter than with conventional modes of instruction.

Basic Hydrodynamics of Richtmyer-Meshkov-type Growth and Oscillations in the ICF-Relevant Conditions

DTIC Science & Technology

2010-01-01

Washington, DC 20375 3ARTEP Inc ., Ellicott City, Maryland 21042 4Department of Mechanical Engineering, Ben Gurion University, Beer Sheva, Israel...the 56-beam Nike KrF laser facility at the Naval Research Laboratory (3 kJ in 0.248 μm, see Obenschain et al. 1996). Basic hydrodynamics of Richtmyer...2000 Nike (NRL) 0.248 8-13 4 400 40 30, 45 1.85 Si monochrom. Ablative RMI, feedout, classical RMI, impulsive loading, re- shock

Advanced Methods for Acoustic and Thrust Benefits for Aircraft Engine Nozzles

NASA Technical Reports Server (NTRS)

Morgan, Morris H., III; Gilinsky, Mikhail M.

2000-01-01

The Fluid Mechanics and Acoustics Laboratory (FM&AL) was established At Hampton University in June of 1996. In addition, the FM&AL jointly conducted research with the Central AeroHydrodynamics Institute (TsAGI, Moscow) in Russia under a 2.5 year Civilian Research and Development Foundation (CRDF). The goals of the FM&AL programs are two fold: 1) to improve the working efficiency of the FM&AL team in generating new innovative ideas and in conducting research in the field of fluid dynamics and acoustics, basically for improvement of supersonic and subsonic aircraft engines, and 2) to attract promising minority students to this research and training and, in cooperation with other HU departments, to teach them basic knowledge in Aerodynamics, Gas Dynamics, and Theoretical and Experimental Methods in Aeroacoustics and Computational Fluid Dynamics (CFD). The research at the FM&AL supports reduction schemes associated with the emission of engine pollutants for commercial aircraft and concepts for reduction of observables for military aircraft. These research endeavors relate to the goals of the NASA Strategic Enterprise in Aeronautics concerning the development of environmentally acceptable aircraft. It is in this precise area, where the US aircraft industry, academia, and Government are in great need of trained professionals and which is a high priority goal of the Minority University Research and Education (MUREP) Program, that the HU FM&AL can make its most important contribution. This project already benefits NASA and HU because: First, the innovation, testing, and further development of new techniques for advanced propulsion systems are necessary for the successful attainment of the NASA Long Term Goals in Aeronautics and Space Transportation Technology (ASTT) including Global Civil Aviation, Revolutionary Technology Leaps, Access to Space, R&D Services, and the economic competitiveness of the US Aircraft Industry in the 2 1 st century. Secondly, the joint theoretical and experimental research and training by the GRC-HU Teams aids: using advanced methods and experience in Aerospace Engineering for domestic industries and training of HU students for interesting innovative work in the numerical simulation field as well as engineering and experimental research. HU students use and modify existing numerical codes for the solution of actual applied problems of the NASA Langley Research Center (LaRC)

Comparison of measured and calculated forces on the RE-1000 free-piston Stirling engine displacer

NASA Technical Reports Server (NTRS)

Schreiber, Jeffrey G.

1987-01-01

The NASA Lewis Research Center has tested a 1 kW free-piston Stirling engine at the NASA Lewis test facilities. The tests performed over the past several years on the RE-1000 single cylinder engine are known as the sensitivity tests. This report presents an analysis of some of the data published in the sensitivity test report. A basic investigation into the measured forces acting on the unconstrained displacer of the engine is presented. These measured forces are then correlated with the values predicted by the NASA Lewis Stirling engine computer simulation. The results of the investigation are presented in the form of phasor diagrams. Possible future work resulting from this investigation is outlined.

Integration of NASA Research into Undergraduate Education in Math, Science, Engineering and Technology at North Carolina A&T State University

NASA Technical Reports Server (NTRS)

Monroe, Joseph; Kelkar, Ajit

2003-01-01

The NASA PAIR program incorporated the NASA-Sponsored research into the undergraduate environment at North Carolina Agricultural and Technical State University. This program is designed to significantly improve undergraduate education in the areas of mathematics, science, engineering, and technology (MSET) by directly benefiting from the experiences of NASA field centers, affiliated industrial partners and academic institutions. The three basic goals of the program were enhancing core courses in MSET curriculum, upgrading core-engineering laboratories to compliment upgraded MSET curriculum, and conduct research training for undergraduates in MSET disciplines through a sophomore shadow program and through Research Experience for Undergraduates (REU) programs. Since the inception of the program nine courses have been modified to include NASA related topics and research. These courses have impacted over 900 students in the first three years of the program. The Electrical Engineering circuit's lab is completely re-equipped to include Computer controlled and data acquisition equipment. The Physics lab is upgraded to implement better sensory data acquisition to enhance students understanding of course concepts. In addition a new instrumentation laboratory in the department of Mechanical Engineering is developed. Research training for A&T students was conducted through four different programs: Apprentice program, Developers program, Sophomore Shadow program and Independent Research program. These programs provided opportunities for an average of forty students per semester.

Problems of information support in scientific research

NASA Astrophysics Data System (ADS)

Shamaev, V. G.; Gorshkov, A. B.

2015-11-01

This paper reports on the creation of the open access Akustika portal (AKDATA.RU) designed to provide Russian-language easy-to-read and search information on acoustics and related topics. The absence of a Russian-language publication in foreign databases means that it is effectively lost for much of the scientific community. The portal has three interrelated sections: the Akustika information search system (ISS) (Acoustics), full-text archive of the Akusticheskii Zhurnal (Acoustic Journal), and 'Signal'naya informatsiya' ('Signaling information') on acoustics. The paper presents a description of the Akustika ISS, including its structure, content, interface, and information search capabilities for basic and applied research in diverse areas of science, engineering, biology, medicine, etc. The intended users of the portal are physicists, engineers, and engineering technologists interested in expanding their research activities and seeking to increase their knowledge base. Those studying current trends in the Russian-language contribution to international science may also find the portal useful.

Nanomanufacturing-related programs at NSF

NASA Astrophysics Data System (ADS)

Cooper, Khershed P.

2015-08-01

The National Science Foundation is meeting the challenge of transitioning lab-scale nanoscience and technology to commercial-scale through several nanomanufacturing-related research programs. The goal of the core Nanomanufacturing (NM) and the inter-disciplinary Scalable Nanomanufacturing (SNM) programs is to meet the barriers to manufacturability at the nano-scale by developing the fundamental principles for the manufacture of nanomaterials, nanostructures, nanodevices, and engineered nanosystems. These programs address issues such as scalability, reliability, quality, performance, yield, metrics, and cost, among others. The NM and SNM programs seek nano-scale manufacturing ideas that are transformative, that will be widely applicable and that will have far-reaching technological and societal impacts. It is envisioned that the results from these basic research programs will provide the knowledge base for larger programs such as the manufacturing Nanotechnology Science and Engineering Centers (NSECs) and the Nanosystems Engineering Research Centers (NERCs). Besides brief descriptions of these different programs, this paper will include discussions on novel

Encouraging entrepreneurship in university labs: Research activities, research outputs, and early doctorate careers

PubMed Central

2017-01-01

This paper investigates how the encouragement of entrepreneurship within university research labs relates with research activities, research outputs, and early doctorate careers. Utilizing a panel survey of 6,840 science & engineering doctoral students at 39 R1 research universities, this study shows that entrepreneurship is widely encouraged across university research labs, ranging from 54% in biomedical engineering to 18% in particle physics, while only a small share of labs openly discourage entrepreneurship, from approximately 3% in engineering to approximately 12% in the life sciences. Within fields, there is no difference between labs that encourage entrepreneurship and those that do not with respect to basic research activity and the number of publications. At the same time, labs that encourage entrepreneurship are significantly more likely to report invention disclosures, particularly in engineering where such labs are 41% more likely to disclose inventions. With respect to career pathways, PhDs students in labs that encourage entrepreneurship do not differ from other PhDs in their interest in academic careers, but they are 87% more likely to be interested in careers in entrepreneurship and 44% more likely to work in a startup after graduation. These results persist even when accounting for individuals’ pre-PhD interest in entrepreneurship and the encouragement of other non-academic industry careers. PMID:28178270

Encouraging entrepreneurship in university labs: Research activities, research outputs, and early doctorate careers.

PubMed

Roach, Michael

2017-01-01

This paper investigates how the encouragement of entrepreneurship within university research labs relates with research activities, research outputs, and early doctorate careers. Utilizing a panel survey of 6,840 science & engineering doctoral students at 39 R1 research universities, this study shows that entrepreneurship is widely encouraged across university research labs, ranging from 54% in biomedical engineering to 18% in particle physics, while only a small share of labs openly discourage entrepreneurship, from approximately 3% in engineering to approximately 12% in the life sciences. Within fields, there is no difference between labs that encourage entrepreneurship and those that do not with respect to basic research activity and the number of publications. At the same time, labs that encourage entrepreneurship are significantly more likely to report invention disclosures, particularly in engineering where such labs are 41% more likely to disclose inventions. With respect to career pathways, PhDs students in labs that encourage entrepreneurship do not differ from other PhDs in their interest in academic careers, but they are 87% more likely to be interested in careers in entrepreneurship and 44% more likely to work in a startup after graduation. These results persist even when accounting for individuals' pre-PhD interest in entrepreneurship and the encouragement of other non-academic industry careers.

A Global Assessment of Stem Cell Engineering

PubMed Central

Loring, Jeanne F.; McDevitt, Todd C.; Palecek, Sean P.; Schaffer, David V.; Zandstra, Peter W.

2014-01-01

Over the last 2 years a global assessment of stem cell engineering (SCE) was conducted with the sponsorship of the National Science Foundation, the National Cancer Institute at the National Institutes of Health, and the National Institute of Standards and Technology. The purpose was to gather information on the worldwide status and trends in SCE, that is, the involvement of engineers and engineering approaches in the stem cell field, both in basic research and in the translation of research into clinical applications and commercial products. The study was facilitated and managed by the World Technology Evaluation Center. The process involved site visits in both Asia and Europe, and it also included several different workshops. From this assessment, the panel concluded that there needs to be an increased role for engineers and the engineering approach. This will provide a foundation for the generation of new markets and future economic growth. To do this will require an increased investment in engineering, applied research, and commercialization as it relates to stem cell research and technology. It also will require programs that support interdisciplinary teams, new innovative mechanisms for academic–industry partnerships, and unique translational models. In addition, the global community would benefit from forming strategic partnerships between countries that can leverage existing and emerging strengths in different institutions. To implement such partnerships will require multinational grant programs with appropriate review mechanisms. PMID:24428577

A global assessment of stem cell engineering.

PubMed

Loring, Jeanne F; McDevitt, Todd C; Palecek, Sean P; Schaffer, David V; Zandstra, Peter W; Nerem, Robert M

2014-10-01

Over the last 2 years a global assessment of stem cell engineering (SCE) was conducted with the sponsorship of the National Science Foundation, the National Cancer Institute at the National Institutes of Health, and the National Institute of Standards and Technology. The purpose was to gather information on the worldwide status and trends in SCE, that is, the involvement of engineers and engineering approaches in the stem cell field, both in basic research and in the translation of research into clinical applications and commercial products. The study was facilitated and managed by the World Technology Evaluation Center. The process involved site visits in both Asia and Europe, and it also included several different workshops. From this assessment, the panel concluded that there needs to be an increased role for engineers and the engineering approach. This will provide a foundation for the generation of new markets and future economic growth. To do this will require an increased investment in engineering, applied research, and commercialization as it relates to stem cell research and technology. It also will require programs that support interdisciplinary teams, new innovative mechanisms for academic-industry partnerships, and unique translational models. In addition, the global community would benefit from forming strategic partnerships between countries that can leverage existing and emerging strengths in different institutions. To implement such partnerships will require multinational grant programs with appropriate review mechanisms.

Thermodynamics and Diffusion Coupling in Alloys—Application-Driven Science

NASA Astrophysics Data System (ADS)

Ågren, John

2012-10-01

As emphasized by Stokes (1997), the common assumption of a linear progression from basic research (science), via applied research, to technological innovations (engineering) should be questioned. In fact, society would gain much by supporting long-term research that stems from practical problems and has usefulness as a key word. Such research may be fundamental, and often, it cannot be distinguished from "basic" research if it were not for its different motivation. The development of the Calphad method and the more recent development of accompanying kinetic approaches for diffusion serve as excellent examples and are the themes of this symposium. The drivers are, e.g., the development of new materials, processes, and lifetime predictions. Many challenges of the utmost practical importance require long-term fundamental research. This presentation will address some of them, e.g., the effect of various ordering phenomena on activation barriers, and the strength and practical importance of correlation effects.

Review of spectral imaging technology in biomedical engineering: achievements and challenges.

PubMed

Li, Qingli; He, Xiaofu; Wang, Yiting; Liu, Hongying; Xu, Dongrong; Guo, Fangmin

2013-10-01

Spectral imaging is a technology that integrates conventional imaging and spectroscopy to get both spatial and spectral information from an object. Although this technology was originally developed for remote sensing, it has been extended to the biomedical engineering field as a powerful analytical tool for biological and biomedical research. This review introduces the basics of spectral imaging, imaging methods, current equipment, and recent advances in biomedical applications. The performance and analytical capabilities of spectral imaging systems for biological and biomedical imaging are discussed. In particular, the current achievements and limitations of this technology in biomedical engineering are presented. The benefits and development trends of biomedical spectral imaging are highlighted to provide the reader with an insight into the current technological advances and its potential for biomedical research.

Genome Engineering with TALE and CRISPR Systems in Neuroscience

PubMed Central

Lee, Han B.; Sundberg, Brynn N.; Sigafoos, Ashley N.; Clark, Karl J.

2016-01-01

Recent advancement in genome engineering technology is changing the landscape of biological research and providing neuroscientists with an opportunity to develop new methodologies to ask critical research questions. This advancement is highlighted by the increased use of programmable DNA-binding agents (PDBAs) such as transcription activator-like effector (TALE) and RNA-guided clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated (Cas) systems. These PDBAs fused or co-expressed with various effector domains allow precise modification of genomic sequences and gene expression levels. These technologies mirror and extend beyond classic gene targeting methods contributing to the development of novel tools for basic and clinical neuroscience. In this Review, we discuss the recent development in genome engineering and potential applications of this technology in the field of neuroscience. PMID:27092173

Genome Engineering with TALE and CRISPR Systems in Neuroscience.

PubMed

Lee, Han B; Sundberg, Brynn N; Sigafoos, Ashley N; Clark, Karl J

2016-01-01

Recent advancement in genome engineering technology is changing the landscape of biological research and providing neuroscientists with an opportunity to develop new methodologies to ask critical research questions. This advancement is highlighted by the increased use of programmable DNA-binding agents (PDBAs) such as transcription activator-like effector (TALE) and RNA-guided clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated (Cas) systems. These PDBAs fused or co-expressed with various effector domains allow precise modification of genomic sequences and gene expression levels. These technologies mirror and extend beyond classic gene targeting methods contributing to the development of novel tools for basic and clinical neuroscience. In this Review, we discuss the recent development in genome engineering and potential applications of this technology in the field of neuroscience.

From biomedical-engineering research to clinical application and industrialization

NASA Astrophysics Data System (ADS)

Taguchi, Tetsushi; Aoyagi, Takao

2012-12-01

The rising costs and aging of the population due to a low birth rate negatively affect the healthcare system in Japan. In 2011, the Council for Science and Technology Policy released the 4th Japan's Science and Technology Basic Policy Report from 2011 to 2015. This report includes two major innovations, 'Life Innovation' and 'Green Innovation', to promote economic growth. Biomedical engineering research is part of 'Life Innovation' and its outcomes are required to maintain people's mental and physical health. It has already resulted in numerous biomedical products, and new ones should be developed using nanotechnology-based concepts. The combination of accumulated knowledge and experience, and 'nanoarchitechtonics' will result in novel, well-designed functional biomaterials. This focus issue contains three reviews and 19 original papers on various biomedical topics, including biomaterials, drug-delivery systems, tissue engineering and diagnostics. We hope that it demonstrates the importance of collaboration among scientists, engineers and clinicians, and will contribute to the further development of biomedical engineering.

A new course and textbook on Physical Models of Living Systems, for science and engineering undergraduates

NASA Astrophysics Data System (ADS)

Nelson, Philip

2015-03-01

I'll describe an intermediate-level course on ``Physical Models of Living Systems.'' The only prerequisite is first-year university physics and calculus. The course is a response to rapidly growing interest among undergraduates in a broad range of science and engineering majors. Students acquire several research skills that are often not addressed in traditional courses: Basic modeling skills Probabilistic modeling skills Data analysis methods Computer programming using a general-purpose platform like MATLAB or Python Dynamical systems, particularly feedback control. These basic skills, which are relevant to nearly any field of science or engineering, are presented in the context of case studies from living systems, including: Virus dynamics Bacterial genetics and evolution of drug resistance Statistical inference Superresolution microscopy Synthetic biology Naturally evolved cellular circuits. Work supported by NSF Grants EF-0928048 and DMR-0832802.

Research pressure instrumentation for NASA Space Shuttle main engine, modification no. 5

NASA Technical Reports Server (NTRS)

Anderson, P. J.; Nussbaum, P.; Gustafson, G.

1984-01-01

The objective of the research project described is to define and demonstrate methods to advance the state of the art of pressure sensors for the space shuttle main engine (SSME). Silicon piezoresistive technology was utilized in completing tasks: generation and testing of three transducer design concepts for solid state applications; silicon resistor characterization at cryogenic temperatures; experimental chip mounting characterization; frequency response optimization and prototype design and fabrication. Excellent silicon sensor performance was demonstrated at liquid nitrogen temperature. A silicon resistor ion implant dose was customized for SSME temperature requirements. A basic acoustic modeling software program was developed as a design tool to evaluate frequency response characteristics.

Curriculum optimization of College of Optical Science and Engineering

NASA Astrophysics Data System (ADS)

Wang, Xiaoping; Zheng, Zhenrong; Wang, Kaiwei; Zheng, Xiaodong; Ye, Song; Zhu, Yuhui

2017-08-01

The optimized curriculum of College of Optical Science and Engineering is accomplished at Zhejiang University, based on new trends from both research and industry. The curriculum includes general courses, foundation courses such as mathematics and physics, major core courses, laboratory courses and several module courses. Module courses include optical system designing, optical telecommunication, imaging and vision, electronics and computer science, optoelectronic sensing and metrology, optical mechanics and materials, basics and extension. These curricula reflect the direction of latest researches and relates closely with optoelectronics. Therefore, students may combine flexibly compulsory courses with elective courses, and establish the personalized curriculum of "optoelectronics + X", according to their individual strengths and preferences.

Opportunities for Multidisciplinary Research in Partnership with Rock Engineers at the Deep Underground Science and Engineering Laboratory

NASA Astrophysics Data System (ADS)

Laughton, C.

2008-12-01

For the last half century the physics community has increasingly turned to the use of underground space to conduct basic research. The community is currently planning to conduct a new generation of underground experiments at the Deep Underground Science and Engineering Laboratory (DUSEL). DUSEL will be constructed within the footprint of the defunct Homestake Gold Mine, located in Lead, South Dakota. Physics proposals call for the construction of new caverns in which to conduct major new experiments. Some of the proposed laboratory facilities will be significantly larger and deeper than any previously constructed. The talk will highlight possible opportunities for integrating multi-disciplinary research in to the cavern construction program, and will stress the need to work closely with design and construction contractors to ensure that research goals can be achieve with minimal impact on project work. The constructors of large caverns should be particularly receptive to, and encouraging of geoscience research that could improve the engineering characterization of the rock mass. An improved understanding of the rock mass, as the host construction material, would result in a more reliable cavern design and construction process, and a reduced construction risk to the Project.

Systems Engineering and Integration for Technology Programs

NASA Technical Reports Server (NTRS)

Kennedy, Kruss J.

2006-01-01

The Architecture, Habitability & Integration group (AH&I) is a system engineering and integration test team within the NASA Crew and Thermal Systems Division (CTSD) at Johnson Space Center. AH&I identifies and resolves system-level integration issues within the research and technology development community. The timely resolution of these integration issues is fundamental to the development of human system requirements and exploration capability. The integration of the many individual components necessary to construct an artificial environment is difficult. The necessary interactions between individual components and systems must be approached in a piece-wise fashion to achieve repeatable results. A formal systems engineering (SE) approach to define, develop, and integrate quality systems within the life support community has been developed. This approach will allow a Research & Technology Program to systematically approach the development, management, and quality of technology deliverables to the various exploration missions. A tiered system engineering structure has been proposed to implement best systems engineering practices across all development levels from basic research to working assemblies. These practices will be implemented through a management plan across all applicable programs, projects, elements and teams. While many of the engineering practices are common to other industries, the implementation is specific to technology development. An accounting of the systems engineering management philosophy will be discussed and the associated programmatic processes will be presented.

An Attempt to Improve Students' Presentation Skills via Course of Graduation Research and its Educational Effects

NASA Astrophysics Data System (ADS)

Yamaguchi, Kenji; Ohtuka, Sigeru; Morita, Shinichi; Matsumoto, Itaru; Yakabe, Masaki; Hayamizu, Yasutaka; Ohtuka, Kouichi

The importance of presentation skills rapidly increases in engineering education in Japan. The authors have applied various teaching-method of presentation skills to the course of graduation research for the fifth-grade students of the mechanical engineering program in Yonago National College of Technology. The lectures including teachers' demonstration and basic skills in presentation have resulted in improvement of students' skills. The meeting for announcing the results of graduation research has been opened to the public in cooperation with the Yonago Chamber of Commerce and Industry to give the students incentives to graduation research as well as presentation. The students have mutually evaluated their presentation to get good opportunities for even self-evaluation. This paper discusses the effects and problems of our educational practice.

Development of an Agile Knowledge Engineering Framework in Support of Multi-Disciplinary Translational Research

PubMed Central

Borlawsky, Tara B.; Dhaval, Rakesh; Hastings, Shannon L.; Payne, Philip R. O.

2009-01-01

In October 2006, the National Institutes of Health launched a new national consortium, funded through Clinical and Translational Science Awards (CTSA), with the primary objective of improving the conduct and efficiency of the inherently multi-disciplinary field of translational research. To help meet this goal, the Ohio State University Center for Clinical and Translational Science has launched a knowledge management initiative that is focused on facilitating widespread semantic interoperability among administrative, basic science, clinical and research computing systems, both internally and among the translational research community at-large, through the integration of domain-specific standard terminologies and ontologies with local annotations. This manuscript describes an agile framework that builds upon prevailing knowledge engineering and semantic interoperability methods, and will be implemented as part this initiative. PMID:21347164

Development of an agile knowledge engineering framework in support of multi-disciplinary translational research.

PubMed

Borlawsky, Tara B; Dhaval, Rakesh; Hastings, Shannon L; Payne, Philip R O

2009-03-01

In October 2006, the National Institutes of Health launched a new national consortium, funded through Clinical and Translational Science Awards (CTSA), with the primary objective of improving the conduct and efficiency of the inherently multi-disciplinary field of translational research. To help meet this goal, the Ohio State University Center for Clinical and Translational Science has launched a knowledge management initiative that is focused on facilitating widespread semantic interoperability among administrative, basic science, clinical and research computing systems, both internally and among the translational research community at-large, through the integration of domain-specific standard terminologies and ontologies with local annotations. This manuscript describes an agile framework that builds upon prevailing knowledge engineering and semantic interoperability methods, and will be implemented as part this initiative.

The 1983 NASA/ASEE Summer Faculty Fellowship Research Program research reports

NASA Technical Reports Server (NTRS)

Horn, W. J. (Editor); Duke, M. B. (Editor)

1983-01-01

The 1983 NASA/ASEE Summary Faculty Fellowship Research Program was conducted by Texas A&M University and the Lyndon B. Johnson Space Center (JSC). The 10-week program was operated under the auspices of the American Society for Engineering Education (ASEE). The basic objectives of the programs, which began in 1965 at JSC and in 1964 nationally, are (1) to further the professional knowledge of qualified engineering and science faculty members, (2) to stimulate an exchange of ideas between participants and NASA, (3) to enrich and refresh the research and teaching activities of participants' institutions, and (4) to contribute to the research objectives of the NASA Centers. The faculty fellows spent 10 weeks at JSC engaged in a research project commensurate with their interests and background. They worked in collaboration with a NASA/JSC colleague. This document is a compilation of final reports on their research during the summer of 1983.

NASA-UVA Light Aerospace Alloy and Structures Technology Program: LA(2)ST

NASA Technical Reports Server (NTRS)

Gangloff, Richard P.; Haviland, John K.; Herakovich, Carl T.; Pilkey, Walter D.; Pindera, Marek-Jerzy; Scully, John R.; Stoner, Glenn E.; Thornton, Earl A.; Wawner, Franklin E., Jr.; Wert, John A.

1993-01-01

The NASA-UVA Light Aerospace Alloy and Structures Technology (LA(2)ST) Program continues a high level of activity, with projects being conducted by graduate students and faculty advisors in the Departments of Materials Science and Engineering, Civil Engineering and Applied Mechanics, and Mechanical and Aerospace Engineering at the University of Virginia. This work is funded by the NASA-Langley Research Center under Grant NAG-1-745. We report on progress achieved between July 1 and December 31, 1992. The objective of the LA(2)ST Program is to conduct interdisciplinary graduate student research on the performance of next generation, light weight aerospace alloys, composites and thermal gradient structures in collaboration with NASA-Langley researchers. Specific technical objectives are presented for each research project. We generally aim to produce relevant data and basic understanding of material mechanical response, corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; new solid and fluid mechanics analyses; measurement advances; and critically, a pool of educated graduate students for aerospace technologies.

NASA Engine Icing Research Overview: Aeronautics Evaluation and Test Capabilities (AETC) Project

NASA Technical Reports Server (NTRS)

Veres, Joseph P.

2015-01-01

The occurrence of ice accretion within commercial high bypass aircraft turbine engines has been reported by airlines under certain atmospheric conditions. Engine anomalies have taken place at high altitudes that have been attributed to ice crystal ingestion by the engine. The ice crystals can result in degraded engine performance, loss of thrust control, compressor surge or stall, and flameout of the combustor. The Aviation Safety Program at NASA has taken on the technical challenge of a turbofan engine icing caused by ice crystals which can exist in high altitude convective clouds. The NASA engine icing project consists of an integrated approach with four concurrent and ongoing research elements, each of which feeds critical information to the next element. The project objective is to gain understanding of high altitude ice crystals by developing knowledge bases and test facilities for testing full engines and engine components. The first element is to utilize a highly instrumented aircraft to characterize the high altitude convective cloud environment. The second element is the enhancement of the Propulsion Systems Laboratory altitude test facility for gas turbine engines to include the addition of an ice crystal cloud. The third element is basic research of the fundamental physics associated with ice crystal ice accretion. The fourth and final element is the development of computational tools with the goal of simulating the effects of ice crystal ingestion on compressor and gas turbine engine performance. The NASA goal is to provide knowledge to the engine and aircraft manufacturing communities to help mitigate, or eliminate turbofan engine interruptions, engine damage, and failures due to ice crystal ingestion.

Controlling Subsurface Fractures and Fluid Flow: A Basic Research Agenda

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pyrak-Nolte, Laura J; DePaolo, Donald J.; Pietraß, Tanja

2015-05-22

From beneath the surface of the earth, we currently obtain about 80-percent of the energy our nation consumes each year. In the future we have the potential to generate billions of watts of electrical power from clean, green, geothermal energy sources. Our planet’s subsurface can also serve as a reservoir for storing energy produced from intermittent sources such as wind and solar, and it could provide safe, long-term storage of excess carbon dioxide, energy waste products and other hazardous materials. However, it is impossible to underestimate the complexities of the subsurface world. These complexities challenge our ability to acquire themore » scientific knowledge needed for the efficient and safe exploitation of its resources. To more effectively harness subsurface resources while mitigating the impacts of developing and using these resources, the U.S. Department of Energy established SubTER – the Subsurface Technology and Engineering RD&D Crosscut team. This DOE multi-office team engaged scientists and engineers from the national laboratories to assess and make recommendations for improving energy-related subsurface engineering. The SubTER team produced a plan with the overall objective of “adaptive control of subsurface fractures and fluid flow.”This plan revolved around four core technological pillars—Intelligent Wellbore Systems that sustain the integrity of the wellbore environment; Subsurface Stress and Induced Seismicity programs that guide and optimize sustainable energy strategies while reducing the risks associated with subsurface injections; Permeability Manipulation studies that improve methods of enhancing, impeding and eliminating fluid flow; and New Subsurface Signals that transform our ability to see into and characterize subsurface systems. The SubTER team developed an extensive R&D plan for advancing technologies within these four core pillars and also identified several areas where new technologies would require additional basic research. In response, the Office of Science, through its Office of Basic Energy Science (BES), convened a roundtable consisting of 15 national lab, university and industry geoscience experts to brainstorm basic research areas that underpin the SubTER goals but are currently underrepresented in the BES research portfolio. Held in Germantown, Maryland on May 22, 2015, the round-table participants developed a basic research agenda that is detailed in this report. Highlights include the following: -A grand challenge calling for advanced imaging of stress and geological processes to help understand how stresses and chemical substances are distributed in the subsurface—knowledge that is critical to all aspects of subsurface engineering; -A priority research direction aimed at achieving control of fluid flow through fractured media; -A priority research direction aimed at better understanding how mechanical and geochemical perturbations to subsurface rock systems are coupled through fluid and mineral interactions; -A priority research direction aimed at studying the structure, permeability, reactivity and other properties of nanoporous rocks, like shale, which have become critical energy materials and exhibit important hallmarks of mesoscale materials; -A cross-cutting theme that would accelerate development of advanced computational methods to describe heterogeneous time-dependent geologic systems that could, among other potential benefits, provide new and vastly improved models of hydraulic fracturing and its environmental impacts; -A cross-cutting theme that would lead to the creation of “geo-architected materials” with controlled repeatable heterogeneity and structure that can be tested under a variety of thermal, hydraulic, chemical and mechanical conditions relevant to subsurface systems; -A cross-cutting theme calling for new laboratory studies on both natural and geo-architected subsurface materials that deploy advanced high-resolution 3D imaging and chemical analysis methods to determine the ;rates and mechanisms of fluid-rock processes, and to test predictive models of such phenomena. Many of the key energy challenges of the future demand a greater understanding of the subsurface world in all of its complexity. This greater under- standing will improve the ability to control and manipulate the subsurface world in ways that will benefit both the economy and the environment. This report provides specific basic research pathways to address some of the most fundamental issues of energy-related subsurface engineering.« less

National Aeronautics and Space Administration (NASA)/American Society for Engineering Education (ASEE) summer faculty fellowship program, 1986, volume 1

NASA Technical Reports Server (NTRS)

Mcinnis, Bayliss (Editor); Goldstein, Stanley (Editor)

1987-01-01

The Johnson Space Center (JSC) NASA/ASEE Summer Faculty Fellowship Program was conducted by the University of Houston. The basic objectives of the program are: (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching objectives of participants' institutions; and (4) to contribute to the research objectives of the NASA Centers. Each faculty fellow spent ten weeks at JSC engaged in a research project commensurate with his interests and background and worked in collaboration with a NASA/JSC colleague. Volume 1 contains sections 1 through 14.

Symposium on the peaceful uses of atomic energy in Australia, 1958, held in Sydney, in June 1958

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Thirty-nine papers presented at the conference are collected here. The papers are divided into five sections: Materials, Power Engineering, Power Auxiliaries and Research Reactors, Basic Sciences, and Associated Techniques. Separate abstracts of each section have been prepared. (T.R.H.)

More than Meets the Eye--Infrared Cameras in Open-Ended University Thermodynamics Labs

ERIC Educational Resources Information Center

Melander, Emil; Haglund, Jesper; Weiszflog, Matthias; Andersson, Staffan

2016-01-01

Educational research has found that students have challenges understanding thermal science. Undergraduate physics students have difficulties differentiating basic thermal concepts, such as heat, temperature, and internal energy. Engineering students have been found to have difficulties grasping surface emissivity as a thermal material property.…

A Content-Oriented Model for Science Exhibit Engineering

ERIC Educational Resources Information Center

Achiam, Marianne Foss

2013-01-01

Recently, science museums have begun to review their educational purposes and redesign their pedagogies. At the most basic level, this entails accounting for the performance of individual exhibits, and indeed, in some cases, research indicates shortcomings in exhibit design: While often successful in prompting visitors to carry out intended…

Design and Testing of a Liquid Nitrous Oxide and Ethanol Fueled Rocket Engine

DOE Office of Scientific and Technical Information (OSTI.GOV)

Youngblood, Stewart

A small-scale, bi-propellant, liquid fueled rocket engine and supporting test infrastructure were designed and constructed at the Energetic Materials Research and Testing Center (EMRTC). This facility was used to evaluate liquid nitrous oxide and ethanol as potential rocket propellants. Thrust and pressure measurements along with high-speed digital imaging of the rocket exhaust plume were made. This experimental data was used for validation of a computational model developed of the rocket engine tested. The developed computational model was utilized to analyze rocket engine performance across a range of operating pressures, fuel-oxidizer mixture ratios, and outlet nozzle configurations. A comparative study ofmore » the modeling of a liquid rocket engine was performed using NASA CEA and Cantera, an opensource equilibrium code capable of being interfaced with MATLAB. One goal of this modeling was to demonstrate the ability of Cantera to accurately model the basic chemical equilibrium, thermodynamics, and transport properties for varied fuel and oxidizer operating conditions. Once validated for basic equilibrium, an expanded MATLAB code, referencing Cantera, was advanced beyond CEAs capabilities to predict rocket engine performance as a function of supplied propellant flow rate and rocket engine nozzle dimensions. Cantera was found to comparable favorably to CEA for making equilibrium calculations, supporting its use as an alternative to CEA. The developed rocket engine performs as predicted, demonstrating the developedMATLAB rocket engine model was successful in predicting real world rocket engine performance. Finally, nitrous oxide and ethanol were shown to perform well as rocket propellants, with specific impulses experimentally recorded in the range of 250 to 260 seconds.« less

SimBRS: A University/Industry Consortium Focused on Simulation Based Solutions for Ground Vehicles

DTIC Science & Technology

2009-07-29

plan is to use the SimBRS contract mechanism to streamline a process that applies research funds into a managed program, that is cognizant to the... designs . Therefore, the challenge for the SimBRS team is to establish an approach based on the capacity of measured data and simulations to support ...by systematically relating appropriate results from measurements and applied research in engineering and science. In turn, basic research and

Why our patients (and we) need basic science research.

PubMed

Schor, Nina F

2013-05-28

In times of fiscal austerity, the tendency is to seek instant, inexpensive gratification. In the case of biomedical research, this means the shortest path to practical clinical implementation. But fueling the translational pipeline with discovery depends critically on allowing the biomedical research community to follow their science where it takes them. Fiscal constraints carry with them the risk of squelching creativity and forfeiting the power of serendipity to provide the substrate for the translational engine in the future.

Extremity war injuries: collaborative efforts in research, host nation care, and disaster preparedness.

PubMed

Pollak, Andrew N; Ficke, Col James R

2010-01-01

The fourth annual Extremity War Injuries (EWI) Symposium addressed ongoing challenges and opportunities in the management of combat-related musculoskeletal injury. The symposium, which also examined host-nation care and disaster preparedness and response, defined opportunities for synergy between several organizations with similar missions and goals. Within the Department of Defense, the Orthopaedic Extremity Trauma Research Program (OETRP) has funded basic research related to a series of protocols first identified and validated at prior EWI symposia. A well-funded clinical research arm of OETRP has been developed to help translate and validate research advances from each of the protocols. The Armed Forces Institute for Regenerative Medicine, a consortium of academic research institutions, employs a tissue-engineering approach to EWI challenges, particularly with regard to tissue loss. Programs within the National Institute of Arthritis and Musculoskeletal and Skin Diseases and throughout the National Institutes of Health have also expanded tissue-engineering efforts by emphasizing robust mechanistic basic science programs. Much of the clinical care delivered by US military medical personnel and nongovernmental agencies has been to host-nation populations; coordinating delivery to maximize the number of injured who receive care requires understanding of the breadth and scope of resources available within the war zone. Similarly, providing the most comprehensive care to the greatest number of injured in the context of domestic mass casualty requires discussion and planning by all groups involved.

2011 Vascular Research Initiatives Conference: basic foundations of translational research in vascular disease.

PubMed

Ziegler, Kenneth R; Dardik, Alan

2011-07-01

The Vascular Research Initiatives Conference (VRIC) is an annual conference organized by the Society for Vascular Surgery (SVS). The 2011 VRIC was held in Chicago (IL, USA) to precede and coincide with the first day of the meeting of the Council on Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) of the American Heart Association. The event is designed to present world class vascular research results, encourage collaboration between vascular surgeons and basic scientists in related disciplines, as well as to stimulate interest in research among aspiring academic vascular surgeons. The 2011 VRIC featured plenary sessions addressing peripheral arterial disease, vascular endothelium and thrombosis, aneurysms, and stem cells and tissue engineering. Recipients of the SVS partner grants with the National Institutes of Health K08 awardees presented their progress reports, and keynote addresses were given by Linda Graham and Frank LoGerfo.

Interfacing microbiology and biotechnology. Conference abstracts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maupin, Julia A.

2001-05-19

The Interfacing Microbiology and Biotechnology Conference was attended by over 100 faculty, post-docs, students, and research scientists from the US, Europe, and Latin America. The conference successfully stimulated communication and the dissemination of knowledge among scientists involved in basic and applied research. The focus of the conference was on microbial physiology and genetics and included sessions on C1 metabolism, archaeal metabolism, proteases and chaperones, gene arrays, and metabolic engineering. The meeting provided the setting for in-depth discussions between scientists who are internationally recognized for their research in these fields. The following objectives were met: (1) The promotion of interaction andmore » future collaborative projects among scientists involved in basic and applied research which incorporates microbial physiology, genetics, and biochemistry; (2) the facilitation of communication of new research findings through seminars, posters, and abstracts; (3 ) the stimulation of enthusiasm and education among participants including graduate and undergraduate students.« less

Modeling a hierarchical structure of factors influencing exploitation policy for water distribution systems using ISM approach

NASA Astrophysics Data System (ADS)

Jasiulewicz-Kaczmarek, Małgorzata; Wyczółkowski, Ryszard; Gładysiak, Violetta

2017-12-01

Water distribution systems are one of the basic elements of contemporary technical infrastructure of urban and rural areas. It is a complex engineering system composed of transmission networks and auxiliary equipment (e.g. controllers, checkouts etc.), scattered territorially over a large area. From the water distribution system operation point of view, its basic features are: functional variability, resulting from the need to adjust the system to temporary fluctuations in demand for water and territorial dispersion. The main research questions are: What external factors should be taken into account when developing an effective water distribution policy? Does the size and nature of the water distribution system significantly affect the exploitation policy implemented? These questions have shaped the objectives of research and the method of research implementation.

Small Engine Component Technology (SECT) study

NASA Technical Reports Server (NTRS)

Larkin, T. R.

1986-01-01

The objective of this study is to identify high payoff technologies for year 2000 small gas turbine engines, and to provide a technology plan to guide research and technology efforts toward revolutionizing the small gas turbine technology base. The goal is to define the required technology to provide a 30 percent reduction in mission fuel burned, to reduce direct operating costs by at least 10 percent, and to provide increased reliability and durability of the gas turbine propulsion system. The baseline established to evaluate the year 2000 technology base was an 8-passenger commercial tilt-rotor aircraft powered by a current technology gas turbine engine. Three basic engine cycles were studied: the simple cycle engine, a waste heat recovery cycle, and a wave rotor engine cycle. For the simple cycle engine, two general arrangements were considered: the traditional concentric spool arrangement and a nonconcentric spool arrangement. Both a regenerative and a recuperative cycle were studied for the waste heat recovery cycle.

Education and research in fluid dynamics

NASA Astrophysics Data System (ADS)

López González-Nieto, P.; Redondo, J. M.; Cano, J. L.

2009-04-01

Fluid dynamics constitutes an essential subject for engineering, since auronautic engineers (airship flights in PBL, flight processes), industrial engineers (fluid transportation), naval engineers (ship/vessel building) up to agricultural engineers (influence of the weather conditions on crops/farming). All the above-mentioned examples possess a high social and economic impact on mankind. Therefore, the fluid dynamics education of engineers is very important, and, at the same time, this subject gives us an interesting methodology based on a cycle relation among theory, experiments and numerical simulation. The study of turbulent plumes -a very important convective flow- is a good example because their theoretical governing equations are simple; it is possible to make experimental plumes in an aesy way and to carry out the corresponding numerical simulatons to verify experimental and theoretical results. Moreover, it is possible to get all these aims in the educational system (engineering schools or institutions) using a basic laboratory and the "Modellus" software.

Experiments in autonomous robotics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamel, W.R.

1987-01-01

The Center for Engineering Systems Advanced Research (CESAR) is performing basic research in autonomous robotics for energy-related applications in hazardous environments. The CESAR research agenda includes a strong experimental component to assure practical evaluation of new concepts and theories. An evolutionary sequence of mobile research robots has been planned to support research in robot navigation, world sensing, and object manipulation. A number of experiments have been performed in studying robot navigation and path planning with planar sonar sensing. Future experiments will address more complex tasks involving three-dimensional sensing, dexterous manipulation, and human-scale operations.

A tutorial on information retrieval: basic terms and concepts

PubMed Central

Zhou, Wei; Smalheiser, Neil R; Yu, Clement

2006-01-01

This informal tutorial is intended for investigators and students who would like to understand the workings of information retrieval systems, including the most frequently used search engines: PubMed and Google. Having a basic knowledge of the terms and concepts of information retrieval should improve the efficiency and productivity of searches. As well, this knowledge is needed in order to follow current research efforts in biomedical information retrieval and text mining that are developing new systems not only for finding documents on a given topic, but extracting and integrating knowledge across documents. PMID:16722601

Kuwaiti engineers' perspectives of the engineering senior design (Capstone) course as related to their professional experiences

NASA Astrophysics Data System (ADS)

Alsagheer, Abdullah

This study looks into transfer of learning and its application in the actual employment of engineering students after graduation. At Kuwait University, a capstone course is being offered that aims to ensure that students amalgamate all kinds of engineering skills to apply to their work. Within a basic interpretive, qualitative study-design methodology, I interviewed 12 engineers who have recently experienced the senior design course at Kuwait University and are presently working in industry. From the analysis, four basic themes emerged that further delineate the focus of the entire study. The themes are 1) need for the capstone course, 2) applicability of and problems with the capstone course, 3) industry problems with training, and 4) students' attitudes toward the capstone course. The study concludes that participants are not transferring engineering skills; rather, they are transferring all types of instructions they have been given during their course of study at the university. A frequent statement is that the capstone course should be improved and specifically that it is necessary to improve upon the timing, schedule, teachers' behavior, contents, and format. The study concludes that Kuwaiti engineers on the whole face problems with time management and management support. The study includes some implications for Kuwait University and recommendations that can provide significant support for the development of the Senior Design (Capstone) Course. For examples: the project must be divided into phases to ensure timely completion of deliverables. In order to motivate students for hard work and to achieve true transfer of learning, Kuwait University is required to communicate with certain organizations to place its students at their research centers for capstone projects. All universities, including Kuwait University, should hire faculty specifically to run the capstone course. In conclusion, the study includes some suggestions for further research studies focused on issues related to the Senior Design (Capstone) Course. Future researchers should focus on developing the project-based course in earlier stages of students' educational program by investigating more about the relationship between student achievement and the market demand.

Building better bone: The weaving of biologic and engineering strategies for managing bone loss.

PubMed

Schwartz, Andrew M; Schenker, Mara L; Ahn, Jaimo; Willett, Nick J

2017-09-01

Segmental bone loss remains a challenging clinical problem for orthopaedic trauma surgeons. In addition to the missing bone itself, the local tissues (soft tissue, vascular) are often highly traumatized as well, resulting in a less than ideal environment for bone regeneration. As a result, attempts at limb salvage become a highly expensive endeavor, often requiring multiple operations and necessitating the use of every available strategy (autograft, allograft, bone graft substitution, Masquelet, bone transport, etc.) to achieve bony union. A cost-sensitive, functionally appropriate, and volumetrically adequate engineered substitute would be practice-changing for orthopaedic trauma surgeons and these patients with difficult clinical problems. In tissue engineering and bone regeneration fields, numerous research efforts continue to make progress toward new therapeutic interventions for segmental bone loss, including novel biomaterial development as well as cell-based strategies. Despite an ever-evolving literature base of these new therapeutic and engineered options, there remains a disconnect with the clinical practice, with very few translating into clinical use. A symposium entitled "Building better bone: The weaving of biologic and engineering strategies for managing bone loss," was presented at the 2016 Orthopaedic Research Society Conference to further explore this engineering-clinical disconnect, by surveying basic, translational, and clinical researchers along with orthopaedic surgeons and proposing ideas for pushing the bar forward in the field of segmental bone loss. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1855-1864, 2017. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

Creative Engineering Based Education with Autonomous Robots Considering Job Search Support

NASA Astrophysics Data System (ADS)

Takezawa, Satoshi; Nagamatsu, Masao; Takashima, Akihiko; Nakamura, Kaeko; Ohtake, Hideo; Yoshida, Kanou

The Robotics Course in our Mechanical Systems Engineering Department offers “Robotics Exercise Lessons” as one of its Problem-Solution Based Specialized Subjects. This is intended to motivate students learning and to help them acquire fundamental items and skills on mechanical engineering and improve understanding of Robotics Basic Theory. Our current curriculum was established to accomplish this objective based on two pieces of research in 2005: an evaluation questionnaire on the education of our Mechanical Systems Engineering Department for graduates and a survey on the kind of human resources which companies are seeking and their expectations for our department. This paper reports the academic results and reflections of job search support in recent years as inherited and developed from the previous curriculum.

Development of an Information Fusion System for Engine Diagnostics and Health Management

NASA Technical Reports Server (NTRS)

Volponi, Allan J.; Brotherton, Tom; Luppold, Robert; Simon, Donald L.

2004-01-01

Aircraft gas-turbine engine data are available from a variety of sources including on-board sensor measurements, maintenance histories, and component models. An ultimate goal of Propulsion Health Management (PHM) is to maximize the amount of meaningful information that can be extracted from disparate data sources to obtain comprehensive diagnostic and prognostic knowledge regarding the health of the engine. Data Fusion is the integration of data or information from multiple sources, to achieve improved accuracy and more specific inferences than can be obtained from the use of a single sensor alone. The basic tenet underlying the data/information fusion concept is to leverage all available information to enhance diagnostic visibility, increase diagnostic reliability and reduce the number of diagnostic false alarms. This paper describes a basic PHM Data Fusion architecture being developed in alignment with the NASA C17 Propulsion Health Management (PHM) Flight Test program. The challenge of how to maximize the meaningful information extracted from disparate data sources to obtain enhanced diagnostic and prognostic information regarding the health and condition of the engine is the primary goal of this endeavor. To address this challenge, NASA Glenn Research Center (GRC), NASA Dryden Flight Research Center (DFRC) and Pratt & Whitney (P&W) have formed a team with several small innovative technology companies to plan and conduct a research project in the area of data fusion as applied to PHM. Methodologies being developed and evaluated have been drawn from a wide range of areas including artificial intelligence, pattern recognition, statistical estimation, and fuzzy logic. This paper will provide a broad overview of this work, discuss some of the methodologies employed and give some illustrative examples.

Metals and Ceramics Division progress report for period ending December 31, 1992

DOE Office of Scientific and Technical Information (OSTI.GOV)

Craig, D.F.; Weir, J.R. Jr.

1993-04-01

This report provides a brief overview of the activities and accomplishments of the division, whose purpose is to provide technical support, primarily in the area of high-temperature materials, for the various technologies being developed by US DOE. Activities range from basic research to industrial research and technology transfer. The division (and the report) is divided into the following: Engineering materials, high-temperature materials, materials science, ceramics, nuclear fuel materials, program activities, collaborative research facilities and technology transfer, and educational programs.

Institute for Sustainable Energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agrawal, Ajay

2016-03-28

Alternate fuels offer unique challenges and opportunities as energy source for power generation, vehicular transportation, and industrial applications. Institute for Sustainable Energy (ISE) at UA conducts innovative research to utilize the complex mix of domestically-produced alternate fuels to achieve low-emissions, high energy-efficiency, and fuel-flexibility. ISE also provides educational and advancement opportunities to students and researchers in the energy field. Basic research probing the physics and chemistry of alternative fuels has generated practical concepts investigated in a burner and engine test platforms.

Future Directions of Supersonic Combustion Research: Air Force/NASA Workshop on Supersonic Combustion

NASA Technical Reports Server (NTRS)

Tishkoff, Julian M.; Drummond, J. Philip; Edwards, Tim; Nejad, Abdollah S.

1997-01-01

The Air Force Office of Scientific Research, the Air Force Wright Laboratory Aero Propulsion and Power Directorate, and the NASA Langley Research Center held a joint supersonic combustion workshop on 14-16 May 1996. The intent of this meeting was to: (1) examine the current state-of-the-art in hydrocarbon and/or hydrogen fueled scramjet research; (2) define the future direction and needs of basic research in support of scramjet technology; and (3) when appropriate, help transition basic research findings to solve the needs of developmental engineering programs in the area of supersonic combustion and fuels. A series of topical sessions were planned. Opening presentations were designed to focus and encourage group discussion and scientific exchange. The last half-day of the workshop was set aside for group discussion of the issues that were raised during the meeting for defining future research opportunities and directions. The following text attempts to summarize the discussions that took place at the workshop.

Summary of atmospheric wind design criteria for wind energy conversion system development

NASA Technical Reports Server (NTRS)

Frost, W.; Turner, R. E.

1979-01-01

Basic design values are presented of significant wind criteria, in graphical format, for use in the design and development of wind turbine generators for energy research. It is a condensed version of portions of the Engineering Handbook on the Atmospheric Environmental Guidelines for Use in Wind Turbine Generator Development.

Gas Dynamics Laboratory or Spheres NASA Langley

NASA Image and Video Library

1965-07-22

L65-5505 In the Gas Dynamics Laboratory, completed in 1951, researchers explored basic aerodynamic, heating and fluid-mechanical problems in the speed range from Mach 1.5 to Mach 8.0. Photograph published in Engineer in Charge: A History of the Langley Aeronautical Laboratory, 1917-1958 by James R. Hansen. Page 348.

Teaching Compound Nouns in ESP: Insights from Cognitive Semantics

ERIC Educational Resources Information Center

Fries, Marie-Hélène

2017-01-01

The objective of this chapter is to explore the relevance of cognitive linguistics for teaching [noun] + [noun] constructions to French learners of English for Specific Purposes (ESP), and more specifically, for process engineering. After a review of research on Compound Nouns (CNs) and explicit versus implicit learning, three basic tenets of…

Concise review: carbon nanotechnology: perspectives in stem cell research.

PubMed

Pryzhkova, Marina V

2013-05-01

Carbon nanotechnology has developed rapidly during the last decade, and carbon allotropes, especially graphene and carbon nanotubes, have already found a wide variety of applications in industry, high-tech fields, biomedicine, and basic science. Electroconductive nanomaterials have attracted great attention from tissue engineers in the design of remotely controlled cell-substrate interfaces. Carbon nanoconstructs are also under extensive investigation by clinical scientists as potential agents in anticancer therapies. Despite the recent progress in human pluripotent stem cell research, only a few attempts to use carbon nanotechnology in the stem cell field have been reported. However, acquired experience with and knowledge of carbon nanomaterials may be efficiently used in the development of future personalized medicine and in tissue engineering.

Synthetic biology expands chemical control of microorganisms.

PubMed

Ford, Tyler J; Silver, Pamela A

2015-10-01

The tools of synthetic biology allow researchers to change the ways engineered organisms respond to chemical stimuli. Decades of basic biology research and new efforts in computational protein and RNA design have led to the development of small molecule sensors that can be used to alter organism function. These new functions leap beyond the natural propensities of the engineered organisms. They can range from simple fluorescence or growth reporting to pathogen killing, and can involve metabolic coordination among multiple cells or organisms. Herein, we discuss how synthetic biology alters microorganisms' responses to chemical stimuli resulting in the development of microbes as toxicity sensors, disease treatments, and chemical factories. Copyright © 2015 Elsevier Ltd. All rights reserved.

Tissue constructs: platforms for basic research and drug discovery.

PubMed

Elson, Elliot L; Genin, Guy M

2016-02-06

The functions, form and mechanical properties of cells are inextricably linked to their extracellular environment. Cells from solid tissues change fundamentally when, isolated from this environment, they are cultured on rigid two-dimensional substrata. These changes limit the significance of mechanical measurements on cells in two-dimensional culture and motivate the development of constructs with cells embedded in three-dimensional matrices that mimic the natural tissue. While measurements of cell mechanics are difficult in natural tissues, they have proven effective in engineered tissue constructs, especially constructs that emphasize specific cell types and their functions, e.g. engineered heart tissues. Tissue constructs developed as models of disease also have been useful as platforms for drug discovery. Underlying the use of tissue constructs as platforms for basic research and drug discovery is integration of multiscale biomaterials measurement and computational modelling to dissect the distinguishable mechanical responses separately of cells and extracellular matrix from measurements on tissue constructs and to quantify the effects of drug treatment on these responses. These methods and their application are the main subjects of this review.

Tissue constructs: platforms for basic research and drug discovery

PubMed Central

Elson, Elliot L.; Genin, Guy M.

2016-01-01

The functions, form and mechanical properties of cells are inextricably linked to their extracellular environment. Cells from solid tissues change fundamentally when, isolated from this environment, they are cultured on rigid two-dimensional substrata. These changes limit the significance of mechanical measurements on cells in two-dimensional culture and motivate the development of constructs with cells embedded in three-dimensional matrices that mimic the natural tissue. While measurements of cell mechanics are difficult in natural tissues, they have proven effective in engineered tissue constructs, especially constructs that emphasize specific cell types and their functions, e.g. engineered heart tissues. Tissue constructs developed as models of disease also have been useful as platforms for drug discovery. Underlying the use of tissue constructs as platforms for basic research and drug discovery is integration of multiscale biomaterials measurement and computational modelling to dissect the distinguishable mechanical responses separately of cells and extracellular matrix from measurements on tissue constructs and to quantify the effects of drug treatment on these responses. These methods and their application are the main subjects of this review. PMID:26855763

A Student Experiment Method for Learning the Basics of Embedded Software Technologies Including Hardware/Software Co-design

NASA Astrophysics Data System (ADS)

Kambe, Hidetoshi; Mitsui, Hiroyasu; Endo, Satoshi; Koizumi, Hisao

The applications of embedded system technologies have spread widely in various products, such as home appliances, cellular phones, automobiles, industrial machines and so on. Due to intensified competition, embedded software has expanded its role in realizing sophisticated functions, and new development methods like a hardware/software (HW/SW) co-design for uniting HW and SW development have been researched. The shortfall of embedded SW engineers was estimated to be approximately 99,000 in the year 2006, in Japan. Embedded SW engineers should understand HW technologies and system architecture design as well as SW technologies. However, a few universities offer this kind of education systematically. We propose a student experiment method for learning the basics of embedded system development, which includes a set of experiments for developing embedded SW, developing embedded HW and experiencing HW/SW co-design. The co-design experiment helps students learn about the basics of embedded system architecture design and the flow of designing actual HW and SW modules. We developed these experiments and evaluated them.

[RESEARCH PROGRESS OF THREE-DIMENSIONAL PRINTING POROUS SCAFFOLDS FOR BONE TISSUE ENGINEERING].

PubMed

Wu, Tianqi; Yang, Chunxi

2016-04-01

To summarize the research progress of several three-dimensional (3-D)-printing scaffold materials in bone tissue engineering. The recent domestic and international articles about 3-D printing scaffold materials were reviewed and summarized. Compared with conventional manufacturing methods, 3-D printing has distinctive advantages, such as enhancing the controllability of the structure and increasing the productivity. In addition to the traditional metal and ceramic scaffolds, 3-D printing scaffolds carrying seeding cells and tissue factors as well as scaffolds filling particular drugs for special need have been paid more and more attention. The development of 3-D printing porous scaffolds have revealed new perspectives in bone repairing. But it is still at the initial stage, more basic and clinical researches are still needed.

Biomass to Liquid Fuels and Electrical Power

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, Steven; McDonald, Timothy; Gallagher, Thomas

This research program provided data on immediate applicability of forest biomass production and logistics models. Also, the research further developed and optimized fractionation techniques that can be used to separate biomass feedstocks into their basic chemical constituents. Finally, additional research established systematic techniques to determine economically feasible technologies for production of biomass-derived synthesis gases that will be used for clean, renewable power generation and for production of liquid transportation fuels. Moreover, this research program continued our efforts to educate the next generation of engineers and scientists needed to implement these technologies.

A Basic Comparison of the Space Shuttle Main Engine and the J-2X Engine

NASA Technical Reports Server (NTRS)

Ayer, Adam

2007-01-01

With the introduction of the new manned space effort through the Constellation Program, there is an interest to have a basic comparison of the current Space Shuttle Main Engine (SSME) to the J-2X engine used for the second stage of both the Ares I and Ares V rockets. This paper seeks to compare size, weight and thrust capabilities while drawing simple conclusions on differences between the two engines.

An Introduction to Thermal-Fluid Engineering

NASA Astrophysics Data System (ADS)

Warhaft, Zellman

1998-01-01

This text is the first to provide an integrated introduction to basic engineering topics and the social implications of engineering practice. Aimed at beginning engineering students, the book presents the basic ideas of thermodynamics, fluid mechanics, heat transfer, and combustion through a real-world engineering situation. It relates the engine to the atmosphere in which it moves and exhausts its waste products. The book also discusses the greenhouse effect and atmospheric inversions, and the social implications of engineering in a crowded world with increasing energy demands. Students in mechanical, civil, agricultural, environmental, aerospace, and chemical engineering will welcome this engaging, well-illustrated introduction to thermal-fluid engineering.

Application for certification, 1990 model-year light-duty vehicles - US Technical Research Company (Peugeot)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Every year, each manufacturer of passenger cars, light-duty trucks, motorcycles, or heavy-duty engines submits to EPA an application for certification. In the application, the manufacturer gives a detailed technical description of the vehicles or engines he intends to market during the upcoming model year. These engineering data include explanations and/or drawings which describe engine/vehicle parameters such as basic engine design, fuel systems, ignition systems and exhaust and evaporative emission control systems. It also provides information on emission test procedures, service accumulation procedures, fuels to be used, and proposed maintenance requirements to be followed during testing. Section 16 of the applicationmore » contains the results of emission testing, a statement of compliance to the regulations, production engine parameters, and a Summary Sheet Input Form on which issuance of a Certificate of Conformity is based.« less

Application for certification, 1989 model year light-duty vehicles - US Technical Research Company (Peugeot)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Every year, each manufacturer of passenger cars, light-duty trucks, motorcycles, or heavy-duty engines submits to EPA an application for certification. In the application, the manufacturer gives a detailed technical description of the vehicles or engines he intends to market during the upcoming model year. These engineering data include explanations and/or drawings which describe engine/vehicle parameters such as basic engine design, fuel systems, ignition systems and exhaust and evaporative emission control systems. It also provides information on emission test procedures, service accumulation procedures, fuels to be used, and proposed maintenance requirements to be followed during testing. Section 16 of the applicationmore » contains the results of emission testing, a statement of compliance to the regulations, production engine parameters, and a Summary Sheet Input Form on which issuance of a Certificate of Conformity is based.« less

Research on Visualization Design Method in the Field of New Media Software Engineering

NASA Astrophysics Data System (ADS)

Deqiang, Hu

2018-03-01

In the new period of increasingly developed science and technology, with the increasingly fierce competition in the market and the increasing demand of the masses, new design and application methods have emerged in the field of new media software engineering, that is, the visualization design method. Applying the visualization design method to the field of new media software engineering can not only improve the actual operation efficiency of new media software engineering but more importantly the quality of software development can be enhanced by means of certain media of communication and transformation; on this basis, the progress and development of new media software engineering in China are also continuously promoted. Therefore, the application of visualization design method in the field of new media software engineering is analysed concretely in this article from the perspective of the overview of visualization design methods and on the basis of systematic analysis of the basic technology.

Charge It! Translating Electric Vehicle Research Results to Engage 7th and 8th Grade Girls

NASA Astrophysics Data System (ADS)

Egbue, Ona; Long, Suzanna; Ng, Ean-Harn

2015-10-01

Despite attempts to generate interest in science and technology careers, US students continue to show reduced interest in science, technology, engineering and mathematics (STEM) majors at the collegiate level. If girls are not engaged in STEM learning by the middle school level, studies show that they are even less likely to choose a science- or engineering-related major. This article presents results from a workshop for 7th and 8th grade girls designed to promote knowledge building in the area of sustainability and alternative energy use in transportation and to stimulate greater interest in STEM subjects. The workshop based on research conducted at University X focused on basic concepts of electric vehicles and electric vehicles' batteries. Tests were conducted to evaluate the students' knowledge and perceptions of electric vehicles and to determine the impact of the workshop. Early exposure to meaningful engineering experiences for these young girls may boost interest and the eventual pursuit of engineering and technology education paths.

Flight-determined benefits of integrated flight-propulsion control systems

NASA Technical Reports Server (NTRS)

Stewart, James F.; Burcham, Frank W., Jr.; Gatlin, Donald H.

1992-01-01

Over the last two decades, NASA has conducted several experiments in integrated flight-propulsion control. Benefits have included improved maneuverability; increased thrust, range, and survivability; reduced fuel consumption; and reduced maintenance. This paper presents the basic concepts for control integration, examples of implementation, and benefits. The F-111E experiment integrated the engine and inlet control systems. The YF-12C incorporated an integral control system involving the inlet, autopilot, autothrottle, airdata, navigation, and stability augmentation systems. The F-15 research involved integration of the engine, flight, and inlet control systems. Further extension of the integration included real-time, onboard optimization of engine, inlet, and flight control variables; a self-repairing flight control system; and an engines-only control concept for emergency control. The F-18A aircraft incorporated thrust vectoring integrated with the flight control system to provide enhanced maneuvering at high angles of attack. The flight research programs and the resulting benefits of each program are described.

The National Solar Observatory Digital Library - a resource for space weather studies

NASA Astrophysics Data System (ADS)

Hill, F.; Erdwurm, W.; Branston, D.; McGraw, R.

2000-09-01

We describe the National Solar Observatory Digital Library (NSODL), consisting of 200GB of on-line archived solar data, a RDBMS search engine, and an Internet HTML-form user interface. The NSODL is open to all users and provides simple access to solar physics data of basic importance for space weather research and forecasting, heliospheric research, and education. The NSODL can be accessed at the URL www.nso.noao.edu/diglib.

Graceful Failure, Engineering, and Planning for Extremes: The Engineering for Climate Extremes Partnership (ECEP)

NASA Astrophysics Data System (ADS)

Bruyere, C. L.; Tye, M. R.; Holland, G. J.; Done, J.

2015-12-01

Graceful failure acknowledges that all systems will fail at some level and incorporates the potential for failure as a key component of engineering design, community planning, and the associated research and development. This is a fundamental component of the ECEP, an interdisciplinary partnership bringing together scientific, engineering, cultural, business and government expertise to develop robust, well-communicated predictions and advice on the impacts of weather and climate extremes in support of decision-making. A feature of the partnership is the manner in which basic and applied research and development is conducted in direct collaboration with the end user. A major ECEP focus is the Global Risk and Resilience Toolbox (GRRT) that is aimed at developing public-domain, risk-modeling and response data and planning system in support of engineering design, and community planning and adaptation activities. In this presentation I will outline the overall ECEP and GRIP activities, and expand on the 'graceful failure' concept. Specific examples for direct assessment and prediction of hurricane impacts and damage potential will be included.

Realization of station for testing asynchronous three-phase motors

NASA Astrophysics Data System (ADS)

Wróbel, A.; Surma, W.

2016-08-01

Nowadays, you cannot imagine the construction and operation of machines without the use of electric motors [13-15]. The proposed position is designed to allow testing of asynchronous three-phase motors. The position consists of a tested engine and the engine running as a load, both engines combined with a mechanical clutch [2]. The value of the load is recorded by measuring shaft created with Strain Gauge Bridge. This concept will allow to study the basic parameters of the engines, visualization motor parameters both vector and scalar controlled, during varying load drive system. In addition, registration during the variable physical parameters of the working electric motor, controlled by a frequency converter or controlled by a contactor will be possible. Position is designed as a teaching and research position to characterize the engines. It will be also possible selection of inverter parameters.

Modeling the lung: Design and development of tissue engineered macro- and micro-physiologic lung models for research use.

PubMed

Nichols, Joan E; Niles, Jean A; Vega, Stephanie P; Argueta, Lissenya B; Eastaway, Adriene; Cortiella, Joaquin

2014-09-01

Respiratory tract specific cell populations, or tissue engineered in vitro grown human lung, have the potential to be used as research tools to mimic physiology, toxicology, pathology, as well as infectious diseases responses of cells or tissues. Studies related to respiratory tract pathogenesis or drug toxicity testing in the past made use of basic systems where single cell populations were exposed to test agents followed by evaluations of simple cellular responses. Although these simple single-cell-type systems provided good basic information related to cellular responses, much more can be learned from cells grown in fabricated microenvironments which mimic in vivo conditions in specialized microfabricated chambers or by human tissue engineered three-dimensional (3D) models which allow for more natural interactions between cells. Recent advances in microengineering technology, microfluidics, and tissue engineering have provided a new approach to the development of 2D and 3D cell culture models which enable production of more robust human in vitro respiratory tract models. Complex models containing multiple cell phenotypes also provide a more reasonable approximation of what occurs in vivo without the confounding elements in the dynamic in vivo environment. The goal of engineering good 3D human models is the formation of physiologically functional respiratory tissue surrogates which can be used as pathogenesis models or in the case of 2D screening systems for drug therapy evaluation as well as human toxicity testing. We hope that this manuscript will serve as a guide for development of future respiratory tract model systems as well as a review of conventional models. © 2014 by the Society for Experimental Biology and Medicine.

Establishment of a bilateral femoral large segmental bone defect mouse model potentially applicable to basic research in bone tissue engineering.

PubMed

Xing, Junchao; Jin, Huiyong; Hou, Tianyong; Chang, Zhengqi; Luo, Fei; Wang, Pinpin; Li, Zhiqiang; Xie, Zhao; Xu, Jianzhong

2014-12-01

To understand the cellular mechanism underlying bone defect healing in the context of tissue engineering, a reliable, reproducible, and standardized load-bearing large segmental bone defect model in small animals is indispensable. The aim of this study was to establish and evaluate a bilateral femoral defect model in mice. Donor mouse bone marrow mesenchymal stem cells (mBMSCs) were obtained from six mice (FVB/N) and incorporated into partially demineralized bone matrix scaffolds to construct tissue-engineered bones. In total, 36 GFP(+) mice were used for modeling. Titanium fixation plates with locking steel wires were attached to the femurs for stabilization, and 2-mm-long segmental bone defects were created in the bilateral femoral midshafts. The defects in the left and right femurs were transplanted with tissue-engineered bones and control scaffolds, respectively. The healing process was monitored by x-ray radiography, microcomputed tomography, and histology. The capacity of the transplanted mBMSCs to recruit host CD31(+) cells was investigated by immunofluorescence and real-time polymerase chain reaction. Postoperatively, no complication was observed, except that two mice died of unknown causes. Stable fixation of femurs and implants with full load bearing was achieved in all animals. The process of bone defect repair was significantly accelerated due to the introduction of mBMSCs. Moreover, the transplanted mBMSCs attracted more host CD31(+) endothelial progenitors into the grafts. The present study established a feasible, reproducible, and clinically relevant bilateral femoral large segmental bone defect mouse model. This model is potentially suitable for basic research in the field of bone tissue engineering. Copyright © 2014 Elsevier Inc. All rights reserved.

New Principles and Basic Approaches for the Curricula of Engineering Degree Courses.

ERIC Educational Resources Information Center

Gargione, Luiz Antonio

This paper presents new principles and basic approaches for the curricula of engineering degree courses. The accentuated evolution of engineering, the fast technological transformations and, still, the impact provoked by government regulations in the field of education in Brazil have called attention to these issues. Following these changes, it…

An Engineered Virus Library as a Resource for the Spectrum-wide Exploration of Virus and Vector Diversity.

PubMed

Zhang, Wenli; Fu, Jun; Liu, Jing; Wang, Hailong; Schiwon, Maren; Janz, Sebastian; Schaffarczyk, Lukas; von der Goltz, Lukas; Ehrke-Schulz, Eric; Dörner, Johannes; Solanki, Manish; Boehme, Philip; Bergmann, Thorsten; Lieber, Andre; Lauber, Chris; Dahl, Andreas; Petzold, Andreas; Zhang, Youming; Stewart, A Francis; Ehrhardt, Anja

2017-05-23

Adenoviruses (Ads) are large human-pathogenic double-stranded DNA (dsDNA) viruses presenting an enormous natural diversity associated with a broad variety of diseases. However, only a small fraction of adenoviruses has been explored in basic virology and biomedical research, highlighting the need to develop robust and adaptable methodologies and resources. We developed a method for high-throughput direct cloning and engineering of adenoviral genomes from different sources utilizing advanced linear-linear homologous recombination (LLHR) and linear-circular homologous recombination (LCHR). We describe 34 cloned adenoviral genomes originating from clinical samples, which were characterized by next-generation sequencing (NGS). We anticipate that this recombineering strategy and the engineered adenovirus library will provide an approach to study basic and clinical virology. High-throughput screening (HTS) of the reporter-tagged Ad library in a panel of cell lines including osteosarcoma disease-specific cell lines revealed alternative virus types with enhanced transduction and oncolysis efficiencies. This highlights the usefulness of this resource. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Laser engines operating by resonance absorption. [thermodynamic feasibility study

NASA Technical Reports Server (NTRS)

Garbuny, M.; Pechersky, M. J.

1976-01-01

Basic tutorial article on the thermodynamic feasibility of laser engines at the present state of the art. Three main options are considered: (1) laser power applied externally to a heat reservoir (boiler approach); (2) internal heating of working fluid by resonance absorption; and (3) direct conversion of selective excitation into work. Only (2) is considered practically feasible at present. Basic concepts and variants, efficiency relations, upper temperature limits of laser engines, selection of absorbing gases, engine walls, bleaching, thermodynamic cycles of optimized laser engines, laser-powered turbines, laser heat pumps are discussed. Photon engines and laser dissociation engines are also considered.

Regenerative dentistry: translating advancements in basic science research to the dental practice.

PubMed

Garcia-Godoy, Franklin; Murray, Peter

2010-01-01

Scientific advances in the creation of restorative biomaterials, in vitro cell culture technology, tissue engineering, molecular biology and the human genome project provide the basis for the introduction of new technologies into dentistry. This review provides an assessment of how tissue engineering, stem cell, genetic transfer, biomaterial and growth factor therapies can be integrated into clinical dental therapies to restore and regenerate oral tissues. In parallel to the creation of a new field in general medicine called "regenerative medicine," we call this field "regenerative dentistry." While the problems of introducing regenerative therapies are substantial, the potential benefits to patients and the profession are equally ground-breaking. In this review, we outline a few areas of interest for the future of oral and dental medicine in which advancements in basic science have already been adapted to fit the goals of 21st century dentistry.

An undergraduate course, and new textbook, on ``Physical Models of Living Systems''

NASA Astrophysics Data System (ADS)

Nelson, Philip

2015-03-01

I'll describe an intermediate-level course on ``Physical Models of Living Systems.'' The only prerequisite is first-year university physics and calculus. The course is a response to rapidly growing interest among undergraduates in several science and engineering departments. Students acquire several research skills that are often not addressed in traditional courses, including: basic modeling skills, probabilistic modeling skills, data analysis methods, computer programming using a general-purpose platform like MATLAB or Python, dynamical systems, particularly feedback control. These basic skills, which are relevant to nearly any field of science or engineering, are presented in the context of case studies from living systems, including: virus dynamics; bacterial genetics and evolution of drug resistance; statistical inference; superresolution microscopy; synthetic biology; naturally evolved cellular circuits. Publication of a new textbook by WH Freeman and Co. is scheduled for December 2014. Supported in part by EF-0928048 and DMR-0832802.

Aerodynamic Database Development for the Hyper-X Airframe Integrated Scramjet Propulsion Experiments

NASA Technical Reports Server (NTRS)

Engelund, Walter C.; Holland, Scott D.; Cockrell, Charles E., Jr.; Bittner, Robert D.

2000-01-01

This paper provides an overview of the activities associated with the aerodynamic database which is being developed in support of NASA's Hyper-X scramjet flight experiments. Three flight tests are planned as part of the Hyper-X program. Each will utilize a small, nonrecoverable research vehicle with an airframe integrated scramjet propulsion engine. The research vehicles will be individually rocket boosted to the scramjet engine test points at Mach 7 and Mach 10. The research vehicles will then separate from the first stage booster vehicle and the scramjet engine test will be conducted prior to the terminal decent phase of the flight. An overview is provided of the activities associated with the development of the Hyper-X aerodynamic database, including wind tunnel test activities and parallel CFD analysis efforts for all phases of the Hyper-X flight tests. A brief summary of the Hyper-X research vehicle aerodynamic characteristics is provided, including the direct and indirect effects of the airframe integrated scramjet propulsion system operation on the basic airframe stability and control characteristics. Brief comments on the planned post flight data analysis efforts are also included.

Potential Collaborative Research topics with Korea’s Agency for Defense Development

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farrar, Charles R.; Todd, Michael D.

2012-08-23

This presentation provides a high level summary of current research activities at the Los Alamos National Laboratory (LANL)-University of California Jacobs School of Engineering (UCSD) Engineering Institute that will be presented at Korea's Agency for Defense Development (ADD). These research activities are at the basic engineering science level with different level of maturity ranging from initial concepts to field proof-of-concept demonstrations. We believe that all of these activities are appropriate for collaborative research activities with ADD subject to approval by each institution. All the activities summarized herein have the common theme that they are multi-disciplinary in nature and typically involvedmore » the integration of high-fidelity predictive modeling, advanced sensing technologies and new development in information technology. These activities include: Wireless Sensor Systems, Swarming Robot sensor systems, Advanced signal processing (compressed sensing) and pattern recognition, Model Verification and Validation, Optimal/robust sensor system design, Haptic systems for large-scale data processing, Cyber-physical security for robots, Multi-source energy harvesting, Reliability-based approaches to damage prognosis, SHMTools software development, and Cyber-physical systems advanced study institute.« less

Tissue engineering and cell-based therapy toward integrated strategy with artificial organs.

PubMed

Gojo, Satoshi; Toyoda, Masashi; Umezawa, Akihiro

2011-09-01

Research in order that artificial organs can supplement or completely replace the functions of impaired or damaged tissues and internal organs has been underway for many years. The recent clinical development of implantable left ventricular assist devices has revolutionized the treatment of patients with heart failure. The emerging field of regenerative medicine, which uses human cells and tissues to regenerate internal organs, is now advancing from basic and clinical research to clinical application. In this review, we focus on the novel biomaterials, i.e., fusion protein, and approaches such as three-dimensional and whole-organ tissue engineering. We also compare induced pluripotent stem cells, directly reprogrammed cardiomyocytes, and somatic stem cells for cell source of future cell-based therapy. Integrated strategy of artificial organ and tissue engineering/regenerative medicine should give rise to a new era of medical treatment to organ failure.

Joint US/Russia TU-144 Engine Ground Tests

NASA Technical Reports Server (NTRS)

Acosta, Waldo A.; Balser, Jeffrey S.; McCartney, Timothy P.; Richter, Charles A.; Woike, Mark R.

1997-01-01

Two engine research experiments were recently completed in Moscow, Russia using an engine from the Tu-144 supersonic transport airplane. This was a joint project between the United States and Russia. Personnel from the NASA Lewis Research Center, General Electric Aircraft Engines, Pratt & Whitney, the Tupolev Design Bureau, and EBP Aircraft LTD worked together as a team to overcome the many technical and cultural challenges. The objective was to obtain large scale inlet data that could be used in the development of a supersonic inlet system for a future High Speed Civil Transport (HSCT). The-first experiment studied the impact of typical inlet structures that have trailing edges in close proximity to the inlet/engine interface plane on the flow characteristics at that plane. The inlet structure simulated the subsonic diffuser of a supersonic inlet using a bifurcated splitter design. The centerbody maximum diameter was designed to permit choking and slightly supercritical operation. The second experiment measured the reflective characteristics of the engine face to incoming perturbations of pressure amplitude. The basic test rig from the first experiment was used with a longer spacer equipped with fast actuated doors. All the objectives set forth at the beginning of the project were met.

Quarterly progress report for the Chemical and Energy Research Section of the Chemical Technology Division, April--June 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jubin, R.T.

The Chemical and Energy Research Section conducts basic and applied research and development in chemical engineering, applied chemistry, and bioprocessing, with an emphasis on energy-driven technologies and advanced chemical separations for nuclear and waste applications. The report describes the various tasks performed within six major areas of research: Hot Cell Operations, Process Chemistry and thermodynamics, Separations and Materials Synthesis, Solution Thermodynamics, biotechnology Research, and Molecular Studies. The name of a technical contact is included with each task described, and readers are encouraged to contact these individuals if they need additional information.

Line integral on engineering mathematics

NASA Astrophysics Data System (ADS)

Wiryanto, L. H.

2018-01-01

Definite integral is a basic material in studying mathematics. At the level of calculus, calculating of definite integral is based on fundamental theorem of calculus, related to anti-derivative, as the inverse operation of derivative. At the higher level such as engineering mathematics, the definite integral is used as one of the calculating tools of line integral. the purpose of this is to identify if there is a question related to line integral, we can use definite integral as one of the calculating experience. The conclusion of this research says that the teaching experience in introducing the relation between both integrals through the engineer way of thinking can motivate and improve students in understanding the material.

Research reports: 1987 NASA/ASEE Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Karr, Gerald R. (Editor); Cothran, Ernestine K. (Editor); Freeman, L. Michael (Editor)

1987-01-01

For the 23rd consecutive year, a NASA/ASEE Summer Faculty Fellowship Program was conducted at the Marshall Space Flight Center (MSFC). The program was conducted by the University of Alabama in Huntsville and MSFC during the period 1 June to 7 August 1987. Operated under the auspices of the American Society for Engineering Education, the MSFC program, as well as those at other NASA Centers, was sponsored by the Office of University Affairs, NASA Headquarters, Washington, D.C. The basic objectives of the program are: (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of the participant's institutions; and (4) to contribute to the research objectives of the NASA Centers. This document is a compilation of Fellow's reports on their research during the Summer of 1987.

Challenges and Opportunities in Interdisciplinary Materials Research Experiences for Undergraduates

NASA Astrophysics Data System (ADS)

Vohra, Yogesh; Nordlund, Thomas

2009-03-01

The University of Alabama at Birmingham (UAB) offer a broad range of interdisciplinary materials research experiences to undergraduate students with diverse backgrounds in physics, chemistry, applied mathematics, and engineering. The research projects offered cover a broad range of topics including high pressure physics, microelectronic materials, nano-materials, laser materials, bioceramics and biopolymers, cell-biomaterials interactions, planetary materials, and computer simulation of materials. The students welcome the opportunity to work with an interdisciplinary team of basic science, engineering, and biomedical faculty but the challenge is in learning the key vocabulary for interdisciplinary collaborations, experimental tools, and working in an independent capacity. The career development workshops dealing with the graduate school application process and the entrepreneurial business activities were found to be most effective. The interdisciplinary university wide poster session helped student broaden their horizons in research careers. The synergy of the REU program with other concurrently running high school summer programs on UAB campus will also be discussed.

FWP executive summaries: basic energy sciences materials sciences and engineering program (SNL/NM).

DOE Office of Scientific and Technical Information (OSTI.GOV)

Samara, George A.; Simmons, Jerry A.

2006-07-01

This report presents an Executive Summary of the various elements of the Materials Sciences and Engineering Program which is funded by the Division of Materials Sciences and Engineering, Office of Basic Energy Sciences, U.S. Department of Energy at Sandia National Laboratories, New Mexico. A general programmatic overview is also presented.

Establishment of a National Wind Energy Center at University of Houston

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Su Su

The DOE-supported project objectives are to: establish a national wind energy center (NWEC) at University of Houston and conduct research to address critical science and engineering issues for the development of future large MW-scale wind energy production systems, especially offshore wind turbines. The goals of the project are to: (1) establish a sound scientific/technical knowledge base of solutions to critical science and engineering issues for developing future MW-scale large wind energy production systems, (2) develop a state-of-the-art wind rotor blade research facility at the University of Houston, and (3) through multi-disciplinary research, introducing technology innovations on advanced wind-turbine materials, processing/manufacturingmore » technology, design and simulation, testing and reliability assessment methods related to future wind turbine systems for cost-effective production of offshore wind energy. To achieve the goals of the project, the following technical tasks were planned and executed during the period from April 15, 2010 to October 31, 2014 at the University of Houston: (1) Basic research on large offshore wind turbine systems (2) Applied research on innovative wind turbine rotors for large offshore wind energy systems (3) Integration of offshore wind-turbine design, advanced materials and manufacturing technologies (4) Integrity and reliability of large offshore wind turbine blades and scaled model testing (5) Education and training of graduate and undergraduate students and post- doctoral researchers (6) Development of a national offshore wind turbine blade research facility The research program addresses both basic science and engineering of current and future large wind turbine systems, especially offshore wind turbines, for MW-scale power generation. The results of the research advance current understanding of many important scientific issues and provide technical information for solving future large wind turbines with advanced design, composite materials, integrated manufacturing, and structural reliability and integrity. The educational program have trained many graduate and undergraduate students and post-doctoral level researchers to learn critical science and engineering of wind energy production systems through graduate-level courses and research, and participating in various projects in center’s large multi-disciplinary research. These students and researchers are now employed by the wind industry, national labs and universities to support the US and international wind energy industry. The national offshore wind turbine blade research facility developed in the project has been used to support the technical and training tasks planned in the program to accomplish their goals, and it is a national asset which is available for used by domestic and international researchers in the wind energy arena.« less

Advanced liner-cooling techniques for gas turbine combustors

NASA Technical Reports Server (NTRS)

Norgren, C. T.; Riddlebaugh, S. M.

1985-01-01

Component research for advanced small gas turbine engines is currently underway at the NASA Lewis Research Center. As part of this program, a basic reverse-flow combustor geometry was being maintained while different advanced liner wall cooling techniques were investigated. Performance and liner cooling effectiveness of the experimental combustor configuration featuring counter-flow film-cooled panels is presented and compared with two previously reported combustors featuring: splash film-cooled liner walls; and transpiration cooled liner walls (Lamilloy).

Large-Eddy Simulation. Guidelines for Its Application to Planetary Boundary Layer Research

DTIC Science & Technology

1984-08-01

34 engineering application of L98 was Deardorff’s simulation of turbulent channel flow, which was carried out at the National Center for Atmospheric...over the past 20 years, and yet in the perception of some observers * the applications of the resulting basic science to practical problem remain...COVERED -- Large Eddy Simulation: Guidelines for its .0 application to planetary boundary layer research Final Report Oct 83-Aug 84 S. PERFORMING ORG

Environics Cumulative Technical Publications Listing, 1968-1979.

DTIC Science & Technology

1979-12-01

Ro’search in the Air Force and performs research in Environmental Chemi.;try, 7 J ~pollut ion monitoring, waste treatment, air pollution control, modeling...Carolina 9. AFWL-TR- Basic Criteria for the National Sanitation Jan 1971 71- j Evaluation of Speciai Foundation Processes or Devices Used in Treating...Mary J . C. Garcia Feb 1971 171-13 graphy of Civil Engineering Research "I3 -~~~ -R "- I"-- - - 12. DE-TN- Ecological Aspects of Ronald J . Sobieralski

Concise Review: Carbon Nanotechnology: Perspectives in Stem Cell Research

PubMed Central

2013-01-01

Carbon nanotechnology has developed rapidly during the last decade, and carbon allotropes, especially graphene and carbon nanotubes, have already found a wide variety of applications in industry, high-tech fields, biomedicine, and basic science. Electroconductive nanomaterials have attracted great attention from tissue engineers in the design of remotely controlled cell-substrate interfaces. Carbon nanoconstructs are also under extensive investigation by clinical scientists as potential agents in anticancer therapies. Despite the recent progress in human pluripotent stem cell research, only a few attempts to use carbon nanotechnology in the stem cell field have been reported. However, acquired experience with and knowledge of carbon nanomaterials may be efficiently used in the development of future personalized medicine and in tissue engineering. PMID:23572053

Advanced Monobore Concept, Development of CFEX Self-Expanding Tubular Technology

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jeff Spray

2007-09-30

The Advanced Monobore Concept--CFEX{copyright} Self-Expanding Tubular Technology Development was a successfully executed fundamental research through field demonstration project. This final report is presented as a progression, according to basic technology development steps. For this project, the research and development steps used were: concept development, engineering analysis, manufacturing, testing, demonstration, and technology transfer. The CFEX{copyright} Technology Development--Advanced Monobore Concept Project successfully completed all of the steps for technology development, covering fundamental research, conceptual development, engineering design, advanced-level prototype construction, mechanical testing, and downhole demonstration. Within an approximately two year period, a partially defined, broad concept was evolved into a substantial newmore » technological area for drilling and production engineering applicable a variety of extractive industries--which was also successfully demonstrated in a test well. The demonstration achievement included an actual mono-diameter placement of two self-expanding tubulars. The fundamental result is that an economical and technically proficient means of casing any size of drilling or production well or borehole is indicated as feasible based on the results of the project. Highlighted major accomplishments during the project's Concept, Engineering, Manufacturing, Demonstration, and Technology Transfer phases, are given.« less

Research Reports: 2001 NASA/ASEE Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Karr, G. (Editor); Pruitt, J. (Editor); Nash-Stevenson, S. (Editor); Freeman, L. M. (Editor); Karr, C. L. (Editor)

2002-01-01

For the thirty-seventh consecutive year, a NASA/ASEE (American Society for Engineering Education) Summer Faculty Fellowship Program was conducted at Marshall Space Flight Center (MSFC). The program was conducted by The University of Alabama in Huntsville and MSFC during the period May 29 - August 3, 2001. Operated under the auspices of the American Society for Engineering Education, the MSFC program, as well as those at other NASA Centers, was sponsored by the University Affairs Office, NASA Headquarters, Washington, DC. The basic objectives of the programs, which are in the thirty-seventh year of operation nationally, are (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of the participants' institutions; and (4) to contribute to the research objectives of the NASA Centers. The Faculty Fellows spent ten weeks at MSFC engaged in a research project compatible with their interests and background and worked in collaboration with a NASA MSFC colleague. This document is a compilation of Fellows' reports on their research during the summer of 2001.

Future heavy duty trucking engine requirements

NASA Technical Reports Server (NTRS)

Strawhorn, L. W.; Suski, V. A.

1985-01-01

Developers of advanced heavy duty diesel engines are engaged in probing the opportunities presented by new materials and techniques. This process is technology driven, but there is neither assurance that the eventual users of the engines so developed will be comfortable with them nor, indeed, that those consumers will continue to exist in either the same form, or numbers as they do today. To ensure maximum payoff of research dollars, the equipment development process must consider user needs. This study defines motor carrier concerns, cost tolerances, and the engine parameters which match the future projected industry needs. The approach taken to do that is to be explained and the results presented. The material to be given comes basically from a survey of motor carrier fleets. It provides indications of the role of heavy duty vehicles in the 1998 period and their desired maintenance and engine performance parameters.

Holographic aids for internal combustion engine flow studies

NASA Technical Reports Server (NTRS)

Regan, C.

1984-01-01

Worldwide interest in improving the fuel efficiency of internal combustion (I.C.) engines has sparked research efforts designed to learn more about the flow processes of these engines. The flow fields must be understood prior to fuel injection in order to design efficient valves, piston geometries, and fuel injectors. Knowledge of the flow field is also necessary to determine the heat transfer to combustion chamber surfaces. Computational codes can predict velocity and turbulence patterns, but experimental verification is mandatory to justify their basic assumptions. Due to their nonintrusive nature, optical methods are ideally suited to provide the necessary velocity verification data. Optical sytems such as Schlieren photography, laser velocimetry, and illuminated particle visualization are used in I.C. engines, and now their versatility is improved by employing holography. These holographically enhanced optical techniques are described with emphasis on their applications in I.C. engines.

Characteristics and engineering properties of residual soil of volcanic deposits

NASA Astrophysics Data System (ADS)

Wibawa, Y. S.; Sugiarti, K.; Soebowo, E.

2018-02-01

Residual soil knowledge of volcanic-sedimentary rock products provides important information on the soil bearing capacity and its engineering properties. The residual soil is the result of weathering commonly found in unsaturated conditions, having varied geotechnical characteristics at each level of weathering. This paper summarizes the results of the research from the basic engineering properties of residual soil of volcanic-sedimentary rocks from several different locations. The main engineering properties of residual soil such as specific gravity, porosity, grain size, clay content (X-Ray test) and soil shear strength are performed on volcanic rock deposits. The results show that the variation of the index and engineering properties and the microstructure properties of residual soil have the correlation between the depths of weathering levels. Pore volume and pore size distribution on weathered rock profiles can be used as an indication of weathering levels in the tropics.

Propulsion System Airframe Integration Issues and Aerodynamic Database Development for the Hyper-X Flight Research Vehicle

NASA Technical Reports Server (NTRS)

Engelund, Walter C.; Holland, Scott D.; Cockrell, Charles E., Jr.; Bittner, Robert D.

1999-01-01

NASA's Hyper-X Research Vehicle will provide a unique opportunity to obtain data on an operational airframe integrated scramjet propulsion system at true flight conditions. The airframe integrated nature of the scramjet engine with the Hyper-X vehicle results in a strong coupling effect between the propulsion system operation and the airframe s basic aerodynamic characteristics. Comments on general airframe integrated scramjet propulsion system effects on vehicle aerodynamic performance, stability, and control are provided, followed by examples specific to the Hyper-X research vehicle. An overview is provided of the current activities associated with the development of the Hyper-X aerodynamic database, including wind tunnel test activities and parallel CFD analysis efforts. A brief summary of the Hyper-X aerodynamic characteristics is provided, including the direct and indirect effects of the airframe integrated scramjet propulsion system operation on the basic airframe stability and control characteristics.

Replacement bearing for Rocketdyne SSME HPOTPs using alternate self-lubricating retainer materials

NASA Technical Reports Server (NTRS)

Gleeson, J.; Dufrane, K.; Kannel, J.

1992-01-01

Research was conducted to develop replacement bearings for the Rocketdyne Space Shuttle main engine (SSME) high pressure oxidizer turbopumps (HPOTPs). The replacement bearings consisted of standard balls and races with a special Battelle Self-Lubricating Insert Configuration (BASIC) retainer. The BASIC retainer consists of a phosphor bronze housing with inserts consisting of a polytetrafluoretheylene (PTFE) and bronze compound. The PTFE contacts the balls and the land guiding surface on the outer race. A PTFE transfer film is formed on balls and races, which lubricates the critical interfaces. The BASIC retainer is a one-to-one replacement for the current Armalon retainer, but has superior lubricating properties and is stronger over the broad temperature range anticipated for the HPOTP bearings. As a part of the project 40 sets of balls and races (two sizes) and 52 BASIC retainers were shipped to NASA/MSFC.

Moonshot Science-Risks and Benefits.

PubMed

Casadevall, Arturo; Fang, Ferric C

2016-08-30

Ever since the successful Apollo 11 Moon landing in 1969, a "moonshot" has come to signify a bold effort to achieve a seemingly impossible task. The Obama administration recently called for a moonshot to cure cancer, an initiative that has elicited mixed responses from researchers who welcome additional funding but worry about raising expectations. We suggest that a successful moonshot requires a sufficient understanding of the basic science underlying a problem in question so that efforts can be focused on engineering a solution. Current gaps in our basic knowledge of cancer biology make the cancer moonshot a uniquely challenging endeavor. Nevertheless, history has shown that intensive research efforts have frequently yielded conceptual and technological breakthroughs with unanticipated benefits for society. We expect that this effort will be no different. Copyright © 2016 Casadevall and Fang.

Physics Education in a Multidisciplinary Materials Research Environment

NASA Astrophysics Data System (ADS)

Doyle, W. D.

1997-03-01

The MINT Center, an NSF Materials Research Science and Engineering Center, is a multidisciplinary research program focusing on materials information storage. It involves 17 faculty, 10 post-doctoral fellows and 25 graduate students from six academic programs including Physics, Chemistry, Materials Science, Metallurgical and Materials Engineering, Electric al Engineering and Chemical Engineering, whose research is supported by university, federal and industrial funds. The research facilities (15,000 ft^2) which include faculty and student offices are located in one building and are maintained by the university and the Center at no cost to participating faculty. The academic requirements for the students are determined by the individual departments along relatively rigid, traditional grounds although several materials and device courses are offered for students from all departments. Within the Center, participants work in teams assigning responsibilities and sharing results at regularly scheduled meetings. Bi-weekly research seminars for all participants provide excellent opportunities for students to improve their communication skills and to receive critical input from a large, diverse audience. Strong collaboration with industrial partners in the storage industry supported by workshops, research reviews, internships, industrial visitors and participation in industry consortia give students a broader criteria for self-evaluation, higher motivation and excellent career opportunities. Physics students, because of their rigorous basic training, are an important element in a strong materials sciences program, but they often are deficient in the behavior and characterization of real materials. The curriculum for physics students should be broadened to prepare them fully for a rewarding career in this emerging discipline.

Workshop on Research for Space Exploration: Physical Sciences and Process Technology

NASA Technical Reports Server (NTRS)

Singh, Bhim S.

1998-01-01

This report summarizes the results of a workshop sponsored by the Microgravity Research Division of NASA to define contributions the microgravity research community can provide to advance the human exploration of space. Invited speakers and attendees participated in an exchange of ideas to identify issues of interest in physical sciences and process technologies. This workshop was part of a continuing effort to broaden the contribution of the microgravity research community toward achieving the goals of the space agency in human exploration, as identified in the NASA Human Exploration and Development of Space (HEDS) strategic plan. The Microgravity program is one of NASA'a major links to academic and industrial basic research in the physical and engineering sciences. At present, it supports close to 400 principal investigators, who represent many of the nation's leading researchers in the physical and engineering sciences and biotechnology. The intent of the workshop provided a dialogue between NASA and this large, influential research community, mission planners and industry technical experts with the goal of defining enabling research for the Human Exploration and Development of Space activities to which the microgravity research community can contribute.

Regenerative endodontics and tissue engineering: what the future holds?

PubMed

Goodis, Harold E; Kinaia, Bassam Michael; Kinaia, Atheel M; Chogle, Sami M A

2012-07-01

The work performed by researchers in regenerative endodontics and tissue engineering over the last decades has been superb; however, many questions remain to be answered. The basic biologic mechanisms must be elucidated that will allow the development of dental pulp and dentin in situ. Stress must be placed on the many questions that will lead to the design of effective, safe treatment options and therapies. This article discusses those questions, the answers to which may become the future of regenerative endodontics. The future remains bright, but proper support and patience are required. Copyright © 2012 Elsevier Inc. All rights reserved.

Alternatives for jet engine control

NASA Technical Reports Server (NTRS)

Sain, M. K.

1981-01-01

Research centered on basic topics in the modeling and feedback control of nonlinear dynamical systems is reported. Of special interest were the following topics: (1) the role of series descriptions, especially insofar as they relate to questions of scheduling, in the control of gas turbine engines; (2) the use of algebraic tensor theory as a technique for parameterizing such descriptions; (3) the relationship between tensor methodology and other parts of the nonlinear literature; (4) the improvement of interactive methods for parameter selection within a tensor viewpoint; and (5) study of feedback gain representation as a counterpart to these modeling and parameterization ideas.

Shock Tube Measurements for Liquid Fuels Combustion

DTIC Science & Technology

2006-06-01

UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADP023631 TITLE: Shock Tube Measurements for Liquid Fuels Combustion ... COMBUSTION ARO Contract Number DAAD 19-01-1-0597 Principal Investigator: Ronald K. Hanson Mechanical Engineering Department Stanford University, Stanford CA...94305-3032 SUMMARY/OVERVIEW: We report results of basic research aimed at improving knowledge of the combustion behavior of diesel and jet-related

How Nanotechnology and Biomedical Engineering Are Supporting the Identification of Predictive Biomarkers in Neuro-Oncology.

PubMed

Ganau, Mario; Paris, Marco; Syrmos, Nikolaos; Ganau, Laura; Ligarotti, Gianfranco K I; Moghaddamjou, Ali; Prisco, Lara; Ambu, Rossano; Chibbaro, Salvatore

2018-02-26

The field of neuro-oncology is rapidly progressing and internalizing many of the recent discoveries coming from research conducted in basic science laboratories worldwide. This systematic review aims to summarize the impact of nanotechnology and biomedical engineering in defining clinically meaningful predictive biomarkers with a potential application in the management of patients with brain tumors. Data were collected through a review of the existing English literature performed on Scopus, MEDLINE, MEDLINE in Process, EMBASE, and/or Cochrane Central Register of Controlled Trials: all available basic science and clinical papers relevant to address the above-stated research question were included and analyzed in this study. Based on the results of this systematic review we can conclude that: (1) the advances in nanotechnology and bioengineering are supporting tremendous efforts in optimizing the methods for genomic, epigenomic and proteomic profiling; (2) a successful translational approach is attempting to identify a growing number of biomarkers, some of which appear to be promising candidates in many areas of neuro-oncology; (3) the designing of Randomized Controlled Trials will be warranted to better define the prognostic value of those biomarkers and biosignatures.

NASA's university program: Active grants and research contracts, fiscal year 1978

NASA Technical Reports Server (NTRS)

1978-01-01

As basic policy NASA believes that colleges and universities should be encouraged to participate in the space and aeronautics program to the maximum extent practicable. The NASA objective is to have them bring their scientific, engineering, and social research competence to bear on aerospace problems and on the broader social, economic, and international implications of NASA technical and scientific programs. This annual report is one means of documenting the NASA-university relationship, frequently denoted, collectively, as NASA University Program.

Plans for the development of cryogenic engines for space exploration

NASA Technical Reports Server (NTRS)

Stone, James R.; Shaw, Loretta M.; Aukerman, Carl A.

1991-01-01

The NASA Lewis Research Center (LeRC) is conducting a broad range of basic research and focused technology development activities in both aeronautical and space propulsion. By virtue of the successful conduct of these programs, LeRC is strongly qualified to lead Advanced Development and subsequent development programs on cryogenic space propulsion systems on support of the Space Exploration Initiative. A review is provided of technology status, including recent progress in the ongoing activities, and a top level description of the proposed program.

The potential of tissue engineering for developing alternatives to animal experiments: a systematic review.

PubMed

de Vries, Rob B M; Leenaars, Marlies; Tra, Joppe; Huijbregtse, Robbertjan; Bongers, Erik; Jansen, John A; Gordijn, Bert; Ritskes-Hoitinga, Merel

2015-07-01

An underexposed ethical issue raised by tissue engineering is the use of laboratory animals in tissue engineering research. Even though this research results in suffering and loss of life in animals, tissue engineering also has great potential for the development of alternatives to animal experiments. With the objective of promoting a joint effort of tissue engineers and alternative experts to fully realise this potential, this study provides the first comprehensive overview of the possibilities of using tissue-engineered constructs as a replacement of laboratory animals. Through searches in two large biomedical databases (PubMed, Embase) and several specialised 3R databases, 244 relevant primary scientific articles, published between 1991 and 2011, were identified. By far most articles reviewed related to the use of tissue-engineered skin/epidermis for toxicological applications such as testing for skin irritation. This review article demonstrates, however, that the potential for the development of alternatives also extends to other tissues such as other epithelia and the liver, as well as to other fields of application such as drug screening and basic physiology. This review discusses which impediments need to be overcome to maximise the contributions that the field of tissue engineering can make, through the development of alternative methods, to the reduction of the use and suffering of laboratory animals. Copyright © 2013 John Wiley & Sons, Ltd.

Software Re-Engineering of the Human Factors Analysis and Classification System - (Maintenance Extension) Using Object Oriented Methods in a Microsoft Environment

DTIC Science & Technology

2001-09-01

replication) -- all from Visual Basic and VBA . In fact, we found that the SQL Server engine actually had a plethora of options, most formidable of...2002, the new SQL Server 2000 database engine, and Microsoft Visual Basic.NET. This thesis describes our use of the Spiral Development Model to...versions of Microsoft products? Specifically, the pending release of Microsoft Office 2002, the new SQL Server 2000 database engine, and Microsoft

Welding As Science: Applying Basic Engineering Principles to the Discipline

NASA Technical Reports Server (NTRS)

Nunes, A. C., Jr.

2010-01-01

This Technical Memorandum provides sample problems illustrating ways in which basic engineering science has been applied to the discipline of welding. Perhaps inferences may be drawn regarding optimal approaches to particular welding problems, as well as for the optimal education for welding engineers. Perhaps also some readers may be attracted to the science(s) of welding and may make worthwhile contributions to the discipline.

Road to the future of systems biotechnology: CRISPR-Cas-mediated metabolic engineering for recombinant protein production.

PubMed

Roointan, Amir; Morowvat, Mohammad Hossein

The rising potential for CRISPR-Cas-mediated genome editing has revolutionized our strategies in basic and practical bioengineering research. It provides a predictable and precise method for genome modification in a robust and reproducible fashion. Emergence of systems biotechnology and synthetic biology approaches coupled with CRISPR-Cas technology could change the future of cell factories to possess some new features which have not been found naturally. We have discussed the possibility and versatile potentials of CRISPR-Cas technology for metabolic engineering of a recombinant host for heterologous protein production. We describe the mechanisms involved in this metabolic engineering approach and present the diverse features of its application in biotechnology and protein production.

Digital design of scaffold for mandibular defect repair based on tissue engineering*

PubMed Central

Liu, Yun-feng; Zhu, Fu-dong; Dong, Xing-tao; Peng, Wei

2011-01-01

Mandibular defect occurs more frequently in recent years, and clinical repair operations via bone transplantation are difficult to be further improved due to some intrinsic flaws. Tissue engineering, which is a hot research field of biomedical engineering, provides a new direction for mandibular defect repair. As the basis and key part of tissue engineering, scaffolds have been widely and deeply studied in regards to the basic theory, as well as the principle of biomaterial, structure, design, and fabrication method. However, little research is targeted at tissue regeneration for clinic repair operations. Since mandibular bone has a special structure, rather than uniform and regular structure in existing studies, a methodology based on tissue engineering is proposed for mandibular defect repair in this paper. Key steps regarding scaffold digital design, such as external shape design and internal microstructure design directly based on triangular meshes are discussed in detail. By analyzing the theoretical model and the measured data from the test parts fabricated by rapid prototyping, the feasibility and effectiveness of the proposed methodology are properly verified. More works about mechanical and biological improvements need to be done to promote its clinical application in future. PMID:21887853

Digital design of scaffold for mandibular defect repair based on tissue engineering.

PubMed

Liu, Yun-feng; Zhu, Fu-dong; Dong, Xing-tao; Peng, Wei

2011-09-01

Mandibular defect occurs more frequently in recent years, and clinical repair operations via bone transplantation are difficult to be further improved due to some intrinsic flaws. Tissue engineering, which is a hot research field of biomedical engineering, provides a new direction for mandibular defect repair. As the basis and key part of tissue engineering, scaffolds have been widely and deeply studied in regards to the basic theory, as well as the principle of biomaterial, structure, design, and fabrication method. However, little research is targeted at tissue regeneration for clinic repair operations. Since mandibular bone has a special structure, rather than uniform and regular structure in existing studies, a methodology based on tissue engineering is proposed for mandibular defect repair in this paper. Key steps regarding scaffold digital design, such as external shape design and internal microstructure design directly based on triangular meshes are discussed in detail. By analyzing the theoretical model and the measured data from the test parts fabricated by rapid prototyping, the feasibility and effectiveness of the proposed methodology are properly verified. More works about mechanical and biological improvements need to be done to promote its clinical application in future.

Research reports: 1991 NASA/ASEE Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Karr, Gerald R. (Editor); Chappell, Charles R. (Editor); Six, Frank (Editor); Freeman, L. Michael (Editor)

1991-01-01

The basic objectives of the programs, which are in the 28th year of operation nationally, are: (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of the participants' institutions; and (4) to contribute to the research objectives of the NASA Centers. The faculty fellows spent 10 weeks at MSFC engaged in a research project compatible with their interests and background and worked in collaboration with a NASA/MSFC colleague. This is a compilation of their research reports for summer 1991.

Herbert Woodson: encouraging exploration in research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whitaker, R.; Woodson, H.

A profile of Herbert Woodson, an electrical engineering professor, describes his loyalty to fundamental research while consulting and committee activities keep him in touch with the practical end of electricity. He stresses the need to find innovative ways to use electricity that will keep the US competitive. This means focusing at the consumption rather than the production side. As a working member of the Electric Power Research Institute's Advisory Council, he cites learning opportunities from other members and satisfaction with the advisory apparatus. Fundamental research requires adequate funding to pursue an identified problem. Successful industries earmark 5% or more formore » basic research.« less

Fundamental research in artificial intelligence at NASA

NASA Technical Reports Server (NTRS)

Friedland, Peter

1990-01-01

This paper describes basic research at NASA in the field of artificial intelligence. The work is conducted at the Ames Research Center and the Jet Propulsion Laboratory, primarily under the auspices of the NASA-wide Artificial Intelligence Program in the Office of Aeronautics, Exploration and Technology. The research is aimed at solving long-term NASA problems in missions operations, spacecraft autonomy, preservation of corporate knowledge about NASA missions and vehicles, and management/analysis of scientific and engineering data. From a scientific point of view, the research is broken into the categories of: planning and scheduling; machine learning; and design of and reasoning about large-scale physical systems.

Marketing health services: the engineering of satisfaction.

PubMed

MacStravic, R S

1984-12-01

Service marketing is the engineering of satisfaction, and the key to success is to identify and influence potential customers' expectations and then to fulfill those expectations. Patient satisfaction largely determines both a program's revenues and expenditures and the effectiveness of care received by patients. A program's ability to satisfy patients rests upon three basic elements: research, design, and communication. Research should be on two levels. The first is basic market assessment and analysis, and should reveal overall market potential by focusing on consumers' expectations, unmet needs, and level of satisfaction. From this stage of research, the organization should be able to identify current programs that are secure and stable, those which have significant growth potential, those which are threatened by competition, and those which have little future. This research also should indicate the potential for new programs and for new markets for existing programs. The second level of research focuses on a specific program (whether current or proposed) and is the basis for program design. The organization can tailor the program to consumers' expectations in everything from services provided to price of parking and other amenities. Research also provides a basis for communications. Not only can communications influence a potential customer to try a provider, but also care providers can use communications during and after the service experience to reinforce what might have been a casual decision. Ideally, all communication that occurs between patients and providers should serve marketing as well as diagnostic and therapeutic purposes. It can shape patients' expectations, reinforce satisfaction when those expectations have been fulfilled, and convey the provider's caring and concern.

Detecting and (not) dealing with plagiarism in an engineering paper: beyond CrossCheck-a case study.

PubMed

Zhang, Xin-xin; Huo, Zhao-lin; Zhang, Yue-hong

2014-06-01

In papers in areas such as engineering and the physical sciences, figures, tables and formulae are the basic elements to communicate the authors' core ideas, workings and results. As a computational text-matching tool, CrossCheck cannot work on these non-textual elements to detect plagiarism. Consequently, when comparing engineering or physical sciences papers, CrossCheck may return a low similarity index even when plagiarism has in fact taken place. A case of demonstrated plagiarism involving engineering papers with a low similarity index is discussed, and editor's experiences and suggestions are given on how to tackle this problem. The case shows a lack of understanding of plagiarism by some authors or editors, and illustrates the difficulty of getting some editors and publishers to take appropriate action. Consequently, authors, journal editors, and reviewers, as well as research institutions all are duty-bound not only to recognize the differences between ethical and unethical behavior in order to protect a healthy research environment, and also to maintain consistent ethical publishing standards.

Functional Restoration for the Stroke Survivor: Informing the Efforts of Engineers

PubMed Central

Patton, James; Smal, Steven L.; Rymer, William Zev

2009-01-01

As bioengineers begin to notice the importance of therapy in the recovery from stroke and other brain injuries, new technologies will be increasingly conceived, adapted, and designed to improve the patient’s road to recovery. What is clear from engineering history, however, is that the best engineering efforts are often built on strong scientific foundations. In an effort to inform engineers with the necessary background on cutting edge research in the field of stroke and motor recovery, this article summarizes the views of several experts in the field as a result of a workshop held in 2006 on the topic. Here we elaborate on several areas relevant to this goal, including the pathophysiology of stroke and stroke recovery, the biomechanics, the secondary peripheral changes in muscle and other tissue, and the results of neuroimaging studies. One conclusion is that the current state of knowledge is now ripe for research using machines but that highly sophisticated robotic devices may not yet be needed. Instead, what may be needed is basic evidence that shows a difference in one therapeutic strategy over another. PMID:19158061

The upside of noise: engineered dissipation as a resource in superconducting circuits

NASA Astrophysics Data System (ADS)

Kapit, Eliot

2017-09-01

Historically, noise in superconducting circuits has been considered an obstacle to be removed. A large fraction of the research effort in designing superconducting circuits has focused on noise reduction, with great success, as coherence times have increased by four orders of magnitude in the past two decades. However, noise and dissipation can never be fully eliminated, and further, a rapidly growing body of theoretical and experimental work has shown that carefully tuned noise, in the form of engineered dissipation, can be a profoundly useful tool in designing and operating quantum circuits. In this article, I review important applications of engineered dissipation, including state generation, state stabilization, and autonomous quantum error correction, where engineered dissipation can mitigate the effect of intrinsic noise, reducing logical error rates in quantum information processing. Further, I provide a pedagogical review of the basic noise processes in superconducting qubits (photon loss and phase noise), and argue that any dissipative mechanism which can correct photon loss errors is very likely to automatically suppress dephasing. I also discuss applications for quantum simulation, and possible future research directions.

Summaries of FY 1982 research in the chemical sciences

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1982-09-01

The purpose of this booklet is to help those interested in research supported by the Department of Energy's Division of Chemical Sciences, which is one of six Divisions of the Office of Basic Energy Sciences in the Office of Energy Research. These summaries are intended to provide a rapid means for becoming acquainted with the Chemical Sciences program to members of the scientific and technological public and interested persons in the Legislative and Executive Branches of the Government. Areas of research supported by the Division are to be seen in the section headings, the index and the summaries themselves. Energymore » technologies which may be advanced by use of the basic knowledge discovered in this program can be seen in the index and again (by reference) in the summaries. The table of contents lists the following: photochemical and radiation sciences; chemical physics; atomic physics; chemical energy; separation and analysis; chemical engineering sciences; offsite contracts; equipment funds; special facilities; topical index; institutional index for offsite contracts; investigator index.« less

Photonics and web engineering in Poland, WILGA 2009

NASA Astrophysics Data System (ADS)

Romaniuk, Ryszard S.

2009-06-01

The paper is a digest of work presented during a cyclic Ph.D. student symposium on Photonics and Web Engineering WILGA 2009. Symposium is organized by ISE PW in cooperation with professional organizations IEEE, SPIE, PSP and KEiT PAN. There are presented mainly Ph.D. and M.Sc. theses as well as achievements of young researchers. These papers, presented in such a big number, more than 250 in some years, are in certain sense a good digest of the condition of academic research capabilities in this branch of science and technology. The undertaken research subjects for Ph.D. theses in electronics is determined by the interest and research capacity (financial, laboratory and intellectual) of the young researchers and their tutors. Basically, the condition of academic electronics research depends on financing coming from applications areas. During Wilga 2009 there were organized, and thus the paper debates, the following topical sessions concerning applications of advanced electronics and photonics systems: merging of electronic systems and photonics, Internet engineering, distributed measurement systems, security in information technology, astronomy and cosmic technology, HEP experiments, environment protection, image processing and biometry. The paper contains also more general remarks concerning the workshops organized by and for the Ph.D. students in advanced photonics and electronics systems.

Hybrid and conventional hydrogen engine vehicles that meet EZEV emissions

DOE Office of Scientific and Technical Information (OSTI.GOV)

Aceves, S.M.; Smith, J.R.

In this paper, a time-dependent engine model is used for predicting hydrogen engine efficiency and emissions. The model uses basic thermodynamic equations for the compression and expansion processes, along with an empirical correlation for heat transfer, to predict engine indicated efficiency. A friction correlation and a supercharger/turbocharger model are then used to calculate brake thermal efficiency. The model is validated with many experimental points obtained in a recent evaluation of a hydrogen research engine. A The validated engine model is then used to calculate fuel economy and emissions for three hydrogen-fueled vehicles: a conventional, a parallel hybrid, and a seriesmore » hybrid. All vehicles use liquid hydrogen as a fuel. The hybrid vehicles use a flywheel for energy storage. Comparable ultra capacitor or battery energy storage performance would give similar results. This paper analyzes the engine and flywheel sizing requirements for obtaining a desired level of performance. The results indicate that hydrogen lean-burn spark-ignited engines can provide a high fuel economy and Equivalent Zero Emission Vehicle (EZEV) levels in the three vehicle configurations being analyzed.« less

Some aspects of the CI engine modification aimed at operation on LPG with the application of spark ignition

NASA Astrophysics Data System (ADS)

Kaparuk, J.; Luft, S.; Skrzek, T.; Wojtyniak, M.

2016-09-01

A lot of investigation on modification of the compression ignition engine aimed at operation on LPG with the application of spark ignition has been carried out in the Laboratory of Vehicles and Combustion Engines at Kazimierz Pulaski University of Technology and Humanities in Radom. This paper presents results of investigation on establishment of the proper ignition advance angle in the modified engine. Within the framework of this investigation it was assessed the effect of this regulation on basic engine operating parameters, exhaust emission as well as basic combustion parameters.

Basic Solar Energy Research in Japan (2011 EFRC Forum)

ScienceCinema

Domen, Kazunari

2018-02-06

Kazunari Domen, Chemical System Engineering Professor at the University of Tokyo, was the second speaker in the May 26, 2011 EFRC Forum session, "Global Perspectives on Frontiers in Energy Research." In his presentation, Professor Domen talked about basic solar energy research in Japan. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss "Science for our Nation's Energy Future." In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several “grand challenges” and use-inspired “basic research needs” recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

Biomedical engineering education at Politecnico di Milano: development and recent changes.

PubMed

Baselli, G

2009-05-01

The biomedical engineering (BME) programme at the Politecnico di Milano (POLIMI) is characterized by a strong interdisciplinary background in a broad range of engineering subjects applied to biology and medicine. Accordingly, the undergraduate level (3 years) provides a general education, which includes mechanics, chemistry and materials, electronics, and information technology both in the context of general engineering and within BME foundations. In contrast, the postgraduate programme (2 years) offers a broad choice of specializations in BME fields in close connection with the BME research activities and laboratories of the campus and with active interchange with the other engineering disciplines. The history of BME development at POLIMI is briefly recalled, together with the characteristics of educational and research work, which is strongly biased by a large polytechnic university with no medical school within the same campus; points of strength and weakness due to this background are discussed. The introduction of a double cycle (undergraduate and postgraduate) according to the Bologna process (2000) and the effects on the programme structure is considered. An early phase in which professional education was emphasized at undergraduate level is recalled, which was followed by the actual revision fostering basic engineering and BME education at the first level while leaving in-depth specialization to postgraduate studies or to on-the-job training.

Nonlinear dissipative devices in structural vibration control: A review

NASA Astrophysics Data System (ADS)

Lu, Zheng; Wang, Zixin; Zhou, Ying; Lu, Xilin

2018-06-01

Structural vibration is a common phenomenon existing in various engineering fields such as machinery, aerospace, and civil engineering. It should be noted that the effective suppression of structural vibration is conducive to enhancing machine performance, prolonging the service life of devices, and promoting the safety and comfort of structures. Conventional linear energy dissipative devices (linear dampers) are largely restricted for wider application owing to their low performance under certain conditions, such as the detuning effect of tuned mass dampers subjected to nonstationary excitations and the excessively large forces generated in linear viscous dampers at high velocities. Recently, nonlinear energy dissipative devices (nonlinear dampers) with broadband response and high robustness are being increasingly used in practical engineering. At the present stage, nonlinear dampers can be classified into three groups, namely nonlinear stiffness dampers, nonlinear-stiffness nonlinear-damping dampers, and nonlinear damping dampers. Corresponding to each nonlinear group, three types of nonlinear dampers that are widely utilized in practical engineering are reviewed in this paper: the nonlinear energy sink (NES), particle impact damper (PID), and nonlinear viscous damper (NVD), respectively. The basic concepts, research status, engineering applications, and design approaches of these three types of nonlinear dampers are summarized. A comparison between their advantages and disadvantages in practical engineering applications is also conducted, to provide a reference source for practical applications and new research.

A CAL Program to Teach the Basic Principles of Genetic Engineering--A Change from the Traditional Approach.

ERIC Educational Resources Information Center

Dewhurst, D. G.; And Others

1989-01-01

An interactive computer-assisted learning program written for the BBC microcomputer to teach the basic principles of genetic engineering is described. Discussed are the hardware requirements software, use of the program, and assessment. (Author/CW)

Thermodynamics of a Simple Rubber-Band Heat Engine

ERIC Educational Resources Information Center

Mullen, J. G.; And Others

1975-01-01

Outlines the basic engine design and nomenclature, develops some relations between the state parameters of the rubber-band system, defines engine efficiency, and compares the Archibald engine with the Carnot engine. (GS)

Characterization of Nanophase Materials

NASA Astrophysics Data System (ADS)

Wang, Zhong Lin

2000-01-01

Engineering of nanophase materials and devices is of vital interest in electronics, semiconductors and optics, catalysis, ceramics and magnetism. Research associated with nanoparticles has widely spread and diffused into every field of scientific research, forming a trend of nanocrystal engineered materials. The unique properties of nanophase materials are entirely determined by their atomic scale structures, particularly the structures of interfaces and surfaces. Development of nanotechnology involves several steps, of which characterization of nanoparticles is indespensable to understand the behavior and properties of nanoparticles, aiming at implementing nanotechnolgy, controlling their behavior and designing new nanomaterials systems with super performance. The book will focus on structural and property characterization of nanocrystals and their assemblies, with an emphasis on basic physical approach, detailed techniques, data interpretation and applications. Intended readers of this comprehensive reference work are advanced graduate students and researchers in the field, who are specialized in materials chemistry, materials physics and materials science.

Barriers and paths to market for genetically engineered crops.

PubMed

Rommens, Caius M

2010-02-01

Each year, billions of dollars are invested in efforts to improve crops through genetic engineering (GE). These activities have resulted in a surge of publications and patents on technologies and genes: a momentum in basic research that, unfortunately, is not sustained throughout the subsequent phases of product development. After more than two decades of intensive research, the market for transgenic crops is still dominated by applications of just a handful of methods and genes. This discrepancy between research and development reflects difficulties in understanding and overcoming seven main barriers-to-entry: (1) trait efficacy in the field, (2) critical product concepts, (3) freedom-to-operate, (4) industry support, (5) identity preservation and stewardship, (6) regulatory approval and (7) retail and consumer acceptance. In this review, I describe the various roadblocks to market for transgenic crops and also discuss methods and approaches on how to overcome these, especially in the United States.

Engineers Jim Murray and Joe Pahle prepare a deployable, inflatable wing technology demonstrator exp

NASA Technical Reports Server (NTRS)

2001-01-01

Engineers Jim Murray and Joe Pahle prepare a deployable, inflatable wing technology demonstrator experiment flown by the NASA Dryden Flight Research Center, Edwards, California. The inflatable wing project represented a basic flight research effort by Dryden personnel. Three successful flights of the I2000 inflatable wing aircraft occurred. During the flights, the team air-launched the radio-controlled (R/C) I2000 from an R/C utility airplane at an altitude of 800-1000 feet. As the I2000 separated from the carrier aircraft, its inflatable wings 'popped-out,' deploying rapidly via an on-board nitrogen bottle. The aircraft remained stable as it transitioned from wingless to winged flight. The unpowered I2000 glided down to a smooth landing under complete control.

The Stability of Lubricant Oil Acidity of Biogas Fuelled Engine due to Biogas Desulfurization

NASA Astrophysics Data System (ADS)

Gde Tirta Nindhia, Tjokorda; Wayan Surata, I.; Wardana, Ari

2017-05-01

This research is established for the purpose of the understanding the stability of the acidity of lubricant oil in biogas fuelled engine due to the absence of hydrogen sulfide (H2S). As was recognized that other than Methane (CH4), there are also other gas impurities in the biogas such as carbon dioxide (CO2), hydrogen sulfide (H2S), moisture (H2O) and ammonia (NH3). Due to H2S contents in the biogas fuel, the engine was found failure. This is caused by corrosion in the combustion chamber due to increase of lubricant acidity. To overcome this problem in practical, the lubricant is increased the pH to basic level with the hope will be decrease to normal value after several time use. Other method is by installing pH measurement sensor in the engine lubricant so that when lubricant is known turn to be acid, then lubricant replacement should be done. In this research, the effect of biogas desulfurization down to zero level to the acidity of lubricant oil in the four stroke engine was carried out with the hope that neutral lubrication oil to be available during running the engine. The result indicates that by eliminating H2S due desulfurization process, effect on stability and neutrality of pH lubricant. By this method the engine safety can be obtained without often replacement the lubricant oil.

Anthropometry: Basic Studies ad Applications. Volume 1. 1964-1975

DTIC Science & Technology

1977-09-01

Human factors engineering. Cadavers, Moments of inertia, Mass, Aerospace medicine, Tables(Data), Responses IDENTIFIERS: DOT/5A, NTlSDOTHTS PB-241...muscles; head/neck response to low-level acceleration, voluntary isometric muscle force in the lateral direction; and three-dimensional range of motion...Prices: PC$7.50/MFS2.25 \\ 77 22 Whole Body Response Research Program Michigan Univ., Ann Arbor. Dept* of Biomechanics.*General Motors

Discussion and theoretical summarization of the experimental data. [psychophysiology in human factors engineering

NASA Technical Reports Server (NTRS)

Mileryan, Y. A.

1975-01-01

A summary of research on psychological factors that cause substantial changes in the reliability indicators of an operators work is followed by a conclusion that strong moral-volitional qualities are the basic factors that make the human behavior under conditions of stress effective; emotional subcortical subdominants affect a person's conscious organization and self control in a man machine environment.

The 1991 International Aerospace and Ground Conference on Lightning and Static Electricity, volume 2

NASA Technical Reports Server (NTRS)

1991-01-01

The proceedings of the conference are reported. The conference focussed on lightning protection, detection, and forecasting. The conference was divided into 26 sessions based on research in lightning, static electricity, modeling, and mapping. These sessions spanned the spectrum from basic science to engineering, concentrating on lightning prediction and detection and on safety for ground facilities, aircraft, and aerospace vehicles.

Security Engineering Project

DTIC Science & Technology

2015-01-31

from a wireless joystick console broadcasting at 2.4 GHz. Figure 6. GTRI Airborne Unmanned Sensor System As shown in Figure 7 the autopilot has a...generating wind turbines , and video reconnaissance systems on unmanned aerial vehicles (UAVs). The most basic decision problem in designing a...chosen test UAV case was the GTRI Aerial Unmanned Sensor System (GAUSS) aircraft. The GAUSS platform is a small research UAV with a widely used

A Software Technology Transition Entropy Based Engineering Model

DTIC Science & Technology

2002-03-01

Systems Basics, p273). (Prigogine 1997 p81). It is not the place of this research to provide a mathematical formalism with theorems and lemmas. Rather...science). The ancient philosophers, 27 Pythagoras , Protagoras, Socrates, and Plato start the first discourse (the message) that has continued...unpacking of the technology "message" from Pythagoras . This process is characterized by accumulation learning, modeled by learning curves in

Using trading zones and life cycle analysis to understand nanotechnology regulation.

PubMed

Wardak, Ahson; Gorman, Michael E

2006-01-01

This article reviews the public health and environmental regulations applicable to nanotechnology using a life cycle model from basic research through end-of-life for products. Given nanotechnology's immense promise and public investment, regulations are important, balancing risk with the public good. Trading zones and earth systems engineering management assist in explaining potential solutions to gaps in an otherwise complex, overlapping regulatory system.

Therapeutic Genome Editing and its Potential Enhancement through CRISPR Guide RNA and Cas9 Modifications.

PubMed

Batzir, Nurit Assia; Tovin, Adi; Hendel, Ayal

2017-06-01

Genome editing with engineered nucleases is a rapidly growing field thanks to transformative technologies that allow researchers to precisely alter genomes for numerous applications including basic research, biotechnology, and human gene therapy. The genome editing process relies on creating a site-specific DNA double-strand break (DSB) by engineered nucleases and then allowing the cell's repair machinery to repair the break such that precise changes are made to the DNA sequence. The recent development of CRISPR-Cas systems as easily accessible and programmable tools for genome editing accelerates the progress towards using genome editing as a new approach to human therapeutics. Here we review how genome editing using engineered nucleases works and how using different genome editing outcomes can be used as a tool set for treating human diseases. We then review the major challenges of therapeutic genome editing and we discuss how its potential enhancement through CRISPR guide RNA and Cas9 protein modifications could resolve some of these challenges. Copyright© of YS Medical Media ltd.

Generation of a conditional analog-sensitive kinase in human cells using CRISPR/Cas9-mediated genome engineering.

PubMed

Moyer, Tyler C; Holland, Andrew J

2015-01-01

The ability to rapidly and specifically modify the genome of mammalian cells has been a long-term goal of biomedical researchers. Recently, the clustered, regularly interspaced, short palindromic repeats (CRISPR)/Cas9 system from bacteria has been exploited for genome engineering in human cells. The CRISPR system directs the RNA-guided Cas9 nuclease to a specific genomic locus to induce a DNA double-strand break that may be subsequently repaired by homology-directed repair using an exogenous DNA repair template. Here we describe a protocol using CRISPR/Cas9 to achieve bi-allelic insertion of a point mutation in human cells. Using this method, homozygous clonal cell lines can be constructed in 5-6 weeks. This method can also be adapted to insert larger DNA elements, such as fluorescent proteins and degrons, at defined genomic locations. CRISPR/Cas9 genome engineering offers exciting applications in both basic science and translational research. Copyright © 2015 Elsevier Inc. All rights reserved.

Status of FAA Studies in Thermal Acoustics

NASA Astrophysics Data System (ADS)

Lively, John; Ouyang, Zhong; Brasche, Lisa; Holland, Steve; Eisenmann, David; Bantel, Tom; Hassan, Waled

2008-02-01

As with many aerospace applications, commercial jet engine components are operated in demanding environments, often at extreme temperature and stress conditions. The predominant used surface inspection method used on these components is fluorescent penetrant inspection. Research has been ongoing for a number of years on a new technology using a short burst of low frequency (˜20 KHz) ultrasound to "heat up" cracks and make them visible in the infrared range. The basic premise of the Thermal Acoustic method is to use an energy source with recent efforts using an ultrasonic horn originally intended for use in ultrasonic welding to excite the component. The energy source causes an increase in local heating, which is detectable with infrared cameras typically used in Thermographic inspection. While considerable research is underway, additional information on the sensitivity and applicability of this technique to engine components and alloys is needed prior to widespread use in the aviation industry. The purpose of this program is to provide additional data to determine applicability of this method to engine components.

Fundamentals of biomechanics in tissue engineering of bone.

PubMed

Athanasiou, K A; Zhu, C; Lanctot, D R; Agrawal, C M; Wang, X

2000-08-01

The objective of this review is to provide basic information pertaining to biomechanical aspects of bone as they relate to tissue engineering. The review is written for the general tissue engineering reader, who may not have a biomechanical engineering background. To this end, biomechanical characteristics and properties of normal and repair cortical and cancellous bone are presented. Also, this chapter intends to describe basic structure-function relationships of these two types of bone. Special emphasis is placed on salient classical and modern testing methods, with both material and structural properties described.

Increasing the reliability of labor of railroad engineers

NASA Technical Reports Server (NTRS)

Genes, V. S.; Madiyevskiy, Y. M.

1975-01-01

It has been shown that the group of problems related to temporary overloads still require serious development with respect to further automating the basic control operation - programmed selection of speed and braking. The problem of systems for warning the engineer about the condition of the unseen track segments remains a very serious one. Systems of hygenic support of the engineer also require constructive development. The problems of ensuring the reliability of work of engineers in periods of low information load, requiring motor acts, can basically be considered theoretically solved.

[GNU Pattern: open source pattern hunter for biological sequences based on SPLASH algorithm].

PubMed

Xu, Ying; Li, Yi-xue; Kong, Xiang-yin

2005-06-01

To construct a high performance open source software engine based on IBM SPLASH algorithm for later research on pattern discovery. Gpat, which is based on SPLASH algorithm, was developed by using open source software. GNU Pattern (Gpat) software was developped, which efficiently implemented the core part of SPLASH algorithm. Full source code of Gpat was also available for other researchers to modify the program under the GNU license. Gpat is a successful implementation of SPLASH algorithm and can be used as a basic framework for later research on pattern recognition in biological sequences.

Conceptual planning for Space Station life sciences human research project

NASA Technical Reports Server (NTRS)

Primeaux, Gary R.; Miller, Ladonna J.; Michaud, Roger B.

1986-01-01

The Life Sciences Research Facility dedicated laboratory is currently undergoing system definition within the NASA Space Station program. Attention is presently given to the Humam Research Project portion of the Facility, in view of representative experimentation requirement scenarios and with the intention of accommodating the Facility within the Initial Operational Capability configuration of the Space Station. Such basic engineering questions as orbital and ground logistics operations and hardware maintenance/servicing requirements are addressed. Biospherics, calcium homeostasis, endocrinology, exercise physiology, hematology, immunology, muscle physiology, neurosciences, radiation effects, and reproduction and development, are among the fields of inquiry encompassed by the Facility.

Virtual Collaborative Environments for System of Systems Engineering and Applications for ISAT

NASA Technical Reports Server (NTRS)

Dryer, David A.

2002-01-01

This paper describes an system of systems or metasystems approach and models developed to help prepare engineering organizations for distributed engineering environments. These changes in engineering enterprises include competition in increasingly global environments; new partnering opportunities caused by advances in information and communication technologies, and virtual collaboration issues associated with dispersed teams. To help address challenges and needs in this environment, a framework is proposed that can be customized and adapted for NASA to assist in improved engineering activities conducted in distributed, enhanced engineering environments. The approach is designed to prepare engineers for such distributed collaborative environments by learning and applying e-engineering methods and tools to a real-world engineering development scenario. The approach consists of two phases: an e-engineering basics phase and e-engineering application phase. The e-engineering basics phase addresses skills required for e-engineering. The e-engineering application phase applies these skills in a distributed collaborative environment to system development projects.

Basic Gasoline Engine Mechanics. Florida Vocational Program Guide.

ERIC Educational Resources Information Center

University of South Florida, Tampa. Dept. of Adult and Vocational Education.

This packet contains a program guide and Career Merit Achievement Plan (Career MAP) for the implementation of a basic gasoline engine mechanics program in Florida secondary and postsecondary schools. The program guide describes the program content and structure, provides a program description, lists job titles under the program, and includes a…

Basic Drafting: Book One.

ERIC Educational Resources Information Center

Davis, Ronald; And Others

The first of a two-book course in drafting, this manual consists of 13 topics in the following units: introduction to drafting, general safety, basic tools and lines, major equipment, applying for a job, media, lettering, reproduction, drawing sheet layout, architect's scale usage, civil engineer's scale usage, mechanical engineer's scale usage,…

Basic Engineer Equipment Mechanic.

ERIC Educational Resources Information Center

Marine Corps Inst., Washington, DC.

This student guide, one of a series of correspondence training courses designed to improve the job performance of members of the Marine Corps, deals with the skills needed by basic engineer equipment mechanics. Addressed in the four individual units of the course are the following topics: mechanics and their tools (mechanics, hand tools, and power…

Research Reports: 1989 NASA/ASEE Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Karr, Gerald R. (Editor); Six, Frank (Editor); Freeman, L. Michael (Editor)

1989-01-01

For the twenty-fifth consecutive year, a NASA/ASEE Summer Faculty Fellowship Program was conducted at the Marshall Space Flight Center (MSFC). The basic objectives of the programs are: (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of the participants' institutions; and (4) to contribute to the research objectives of the NASA Centers. The Faculty Fellows spent ten weeks at MSFC engaged in a research project compatible with their interests and background and worked in collaboration with a NASA/MSFC colleague.

Beam modulation: A novel ToF-technique for high resolution diffraction at the Beamline for European Materials Engineering Research (BEER)

NASA Astrophysics Data System (ADS)

Rouijaa, M.; Kampmann, R.; Šaroun, J.; Fenske, J.; Beran, P.; Müller, M.; Lukáš, P.; Schreyer, A.

2018-05-01

The Beamline for European Materials Engineering Research (BEER) is under construction at the European Spallation Source (ESS) in Lund, Sweden. A basic requirement on BEER is to make best use of the long ESS pulse (2.86 ms) for engineering investigations. High-resolution diffraction, however, demands timing resolution up to 0.1% corresponding to a pulse length down to about 70 μs for the case of thermal neutrons (λ ∼ 1.8 Å). Such timing resolution can be achieved by pulse shaping techniques cutting a short section out of the long pulse, and thus paying for resolution by strong loss of intensity. In contrast to this, BEER proposes a novel operation mode called pulse modulation technique based on a new chopper design, which extracts several short pulses out of the long ESS pulse, and hence leads to a remarkable gain of intensity compared to nowadays existing conventional pulse shaping techniques. The potential of the new technique can be used with full advantage for investigating strains and textures of highly symmetric materials. Due to its instrument design and the high brilliance of the ESS pulse, BEER is expected to become the European flagship for engineering research for strain mapping and texture analysis.

The Solar-Terrestrial Environment

NASA Astrophysics Data System (ADS)

Hargreaves, John Keith

1995-05-01

The book begins with three introductory chapters that provide some basic physics and explain the principles of physical investigation. The principal material contained in the main part of the book covers the neutral and ionized upper atmosphere, the magnetosphere, and structures, dynamics, disturbances, and irregularities. The concluding chapter deals with technological applications. The account is introductory, at a level suitable for readers with a basic background in engineering or physics. The intent is to present basic concepts, and for that reason, the mathematical treatment is not complex. SI units are given throughout, with helpful notes on cgs units where these are likely to be encountered in the research literature. This book is suitable for advanced undergraduate and graduate students who are taking introductory courses on upper atmospheric, ionospheric, or magnetospheric physics. This is a successor to The Upper Atmosphere and Solar-Terrestrial Relations, published in 1979.

Optoelectronics for electrical and computer engineering students

NASA Astrophysics Data System (ADS)

Chua, Soo-Jin; Jalil, Mansoor

2002-05-01

We describe the contents of an advanced undergraduate course on Optoelectronics at the Department of Electrical and Computer Engineering, National University of Singapore. The emphasis has changed over the years to keep abreast of the development in the field but the broad features remain the same. A multidisciplinary approach is taken, incorporating physics, materials science and engineering concepts to explain the operation of optoelectronic components, and their application in display, communications and consumer electronics. The course comprises of 36 hours of lectures and two experiments, and covers basic radiometry and photometry, photoemitters (LEDs and lasers), photodetectors, and liquid crystal displays. The main aim of the course is to equip the student with the requisite theoretical and practical knowledge for participation in the photonics industry and for postgraduate research for students who are so inclined.

A curriculum for real-time computer and control systems engineering

NASA Technical Reports Server (NTRS)

Halang, Wolfgang A.

1990-01-01

An outline of a syllabus for the education of real-time-systems engineers is given. This comprises the treatment of basic concepts, real-time software engineering, and programming in high-level real-time languages, real-time operating systems with special emphasis on such topics as task scheduling, hardware architectures, and especially distributed automation structures, process interfacing, system reliability and fault-tolerance, and integrated project development support systems. Accompanying course material and laboratory work are outlined, and suggestions for establishing a laboratory with advanced, but low-cost, hardware and software are provided. How the curriculum can be extended into a second semester is discussed, and areas for possible graduate research are listed. The suitable selection of a high-level real-time language and supporting operating system for teaching purposes is considered.

Technological innovation in the United States.

PubMed

Kilgour, F G

1965-01-01

This paper presents nearly three and a half centuries of American invention, and is particularly concerned with primary invention as distinct from development, production, and service engineering. One apparent but not real exception to this statement is that one section will be devoted to the American invention of production engineering. Various factors have stimulated, guided, and inhibited American inventiveness; indeed, colonial status during nearly half the historical period being examined all but stifled technological innovation. It will also become clear that American disenchantment with basic scientific activity diminished the relative magnitude of her innovations after the advent of the technique of applied research in Europe following the middle of the nineteenth century. This circumstance is particularly obvious in the cases of chemical and electrical engineering, the first of the applied sciences.

Systems biology solutions for biochemical production challenges.

PubMed

Hansen, Anne Sofie Lærke; Lennen, Rebecca M; Sonnenschein, Nikolaus; Herrgård, Markus J

2017-06-01

There is an urgent need to significantly accelerate the development of microbial cell factories to produce fuels and chemicals from renewable feedstocks in order to facilitate the transition to a biobased society. Methods commonly used within the field of systems biology including omics characterization, genome-scale metabolic modeling, and adaptive laboratory evolution can be readily deployed in metabolic engineering projects. However, high performance strains usually carry tens of genetic modifications and need to operate in challenging environmental conditions. This additional complexity compared to basic science research requires pushing systems biology strategies to their limits and often spurs innovative developments that benefit fields outside metabolic engineering. Here we survey recent advanced applications of systems biology methods in engineering microbial production strains for biofuels and -chemicals. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

Proven and novel strategies for efficient editing of the human genome.

PubMed

Mussolino, Claudio; Mlambo, Tafadzwa; Cathomen, Toni

2015-10-01

Targeted gene editing with designer nucleases has become increasingly popular. The most commonly used designer nuclease platforms are engineered meganucleases, zinc-finger nucleases, transcription activator-like effector nucleases and the clustered regularly interspaced short palindromic repeat/Cas9 system. These powerful tools have greatly facilitated the generation of plant and animal models for basic research, and harbor an enormous potential for applications in biotechnology and gene therapy. This review recapitulates proven concepts of targeted genome engineering in primary human cells and elaborates on novel concepts that became possible with the dawn of RNA-guided nucleases and RNA-guided transcription factors. Copyright © 2015 Elsevier Ltd. All rights reserved.

Chromatin regulation at the frontier of synthetic biology.

PubMed

Keung, Albert J; Joung, J Keith; Khalil, Ahmad S; Collins, James J

2015-03-01

As synthetic biology approaches are extended to diverse applications throughout medicine, biotechnology and basic biological research, there is an increasing need to engineer yeast, plant and mammalian cells. Eukaryotic genomes are regulated by the diverse biochemical and biophysical states of chromatin, which brings distinct challenges, as well as opportunities, over applications in bacteria. Recent synthetic approaches, including 'epigenome editing', have allowed the direct and functional dissection of many aspects of physiological chromatin regulation. These studies lay the foundation for biomedical and biotechnological engineering applications that could take advantage of the unique combinatorial and spatiotemporal layers of chromatin regulation to create synthetic systems of unprecedented sophistication.

Cumulative reports and publications through December 31, 1989

NASA Technical Reports Server (NTRS)

1990-01-01

A complete list of reports from the Institute for Computer Applications in Science and Engineering (ICASE) is presented. The major categories of the current ICASE research program are: numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; control and parameter identification problems, with emphasis on effectual numerical methods; computational problems in engineering and the physical sciences, particularly fluid dynamics, acoustics, structural analysis, and chemistry; computer systems and software, especially vector and parallel computers, microcomputers, and data management. Since ICASE reports are intended to be preprints of articles that will appear in journals or conference proceedings, the published reference is included when it is available.

Updating the biomedical engineering curriculum: Inclusion of Health Technology Assessment subjects.

PubMed

Martinez Licona, Fabiola; Urbina, Edmundo Gerardo; Azpiroz-Leehan, Joaquin

2010-01-01

This paper describes the work being carried out at Metropolitan Autonomous University (UAM) in Mexico City with regard to the continuous evaluation and updating of the Biomedical Engineering (BME) curriculum. In particular the courses regarded as part of the BME basic branch are reduced and new sets of elective subjects are proposed in order to bring closer the research work at UAM with the subjects in the BME curriculum. Special emphasis is placed on subjects dealing with Health Technology Assessment (HTA) and Health economics, as this branch of the BME discipline is quite promising in Mexico, but there are very few professionals in the field with adequate qualifications.

Chromatin regulation at the frontier of synthetic biology

PubMed Central

Keung, Albert J.; Joung, J. Keith; Khalil, Ahmad S.; Collins, James J.

2016-01-01

As synthetic biology approaches are extended to diverse applications throughout medicine, biotechnology and basic biological research, there is an increasing need to engineer yeast, plant and mammalian cells. Eukaryotic genomes are regulated by the diverse biochemical and biophysical states of chromatin, which brings distinct challenges, as well as opportunities, over applications in bacteria. Recent synthetic approaches, including `epigenome editing', have allowed the direct and functional dissection of many aspects of physiological chromatin regulation. These studies lay the foundation for biomedical and biotechnological engineering applications that could take advantage of the unique combinatorial and spatiotemporal layers of chromatin regulation to create synthetic systems of unprecedented sophistication. PMID:25668787

The NASA Materials Science Research Program - It's New Strategic Goals and Plans

NASA Technical Reports Server (NTRS)

Schlagheck, Ronald A.

2003-01-01

In 2001, the NASA created a separate science enterprise, the Office of Biological and Physical Research (OBPR), to perform strategical and fundamental research bringing together physics, chemistry, biology, and engineering to solve problems needed for future agency mission goals. The Materials Science Program is one of basic research disciplines within this new Enterprise's Division of Physical Sciences Research. The Materials Science Program participates to utilize effective use of International Space Station (ISS) experimental facilities, target new scientific and technology questions, and transfer results for Earth benefits. The program has recently pursued new investigative research in areas necessary to expand NASA knowledge base for exploration of the universe, some of which will need access to the microgravity of space. The program has a wide variety of traditional ground and flight based research related types of basic science related to materials crystallization, fundamental processing, and properties characterization in order to obtain basic understanding of various phenomena effects and relationships to the structures, processing, and properties of materials. A summary of the types and sources for this research is presented and those experiments planned for the space. Areas to help expand the science basis for NASA future missions are described. An overview of the program is given including the scope of the current and future NASA Research Announcements with emphasis on new materials science initiatives. A description of the planned flight experiments to be conducted on the International Space Station program along with the planned facility class Materials Science Research Rack (MSRR) and Microgravity Glovebox (MSG) type investigations.

Integrated design and manufacturing for the high speed civil transport

NASA Technical Reports Server (NTRS)

1993-01-01

In June 1992, Georgia Tech's School of Aerospace Engineering was awarded a NASA University Space Research Association (USRA) Advanced Design Program (ADP) to address 'Integrated Design and Manufacturing for the High Speed Civil Transport (HSCT)' in its graduate aerospace systems design courses. This report summarizes the results of the five courses incorporated into the Georgia Tech's USRA ADP program. It covers AE8113: Introduction to Concurrent Engineering, AE4360: Introduction to CAE/CAD, AE4353: Design for Life Cycle Cost, AE6351: Aerospace Systems Design One, and AE6352: Aerospace Systems Design Two. AE8113: Introduction to Concurrent Engineering was an introductory course addressing the basic principles of concurrent engineering (CE) or integrated product development (IPD). The design of a total system was not the objective of this course. The goal was to understand and define the 'up-front' customer requirements, their decomposition, and determine the value objectives for a complex product, such as the high speed civil transport (HSCT). A generic CE methodology developed at Georgia Tech was used for this purpose. AE4353: Design for Life Cycle Cost addressed the basic economic issues for an HSCT using a robust design technique, Taguchi's parameter design optimization method (PDOM). An HSCT economic sensitivity assessment was conducted using a Taguchi PDOM approach to address the robustness of the basic HSCT design. AE4360: Introduction to CAE/CAD permitted students to develop and utilize CAE/CAD/CAM knowledge and skills using CATIA and CADAM as the basic geometric tools. AE6351: Aerospace Systems Design One focused on the conceptual design refinement of a baseline HSCT configuration as defined by Boeing, Douglas, and NASA in their system studies. It required the use of NASA's synthesis codes FLOPS and ACSYNT. A criterion called the productivity index (P.I.) was used to evaluate disciplinary sensitivities and provide refinements of the baseline HSCT configuration. AE6352: Aerospace Systems Design Two was a continuation of Aerospace Systems Design One in which wing concepts were researched and analyzed in more detail. FLOPS and ACSYNT were again used at the system level while other off-the-shelf computer codes were used for more detailed wing disciplinary analysis and optimization. The culmination of all efforts and submission of this report conclude the first year's efforts of Georgia Tech's NASA USRA ADP. It will hopefully provide the foundation for next year's efforts concerning continuous improvement of integrated design and manufacturing for the HSCT.

Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study.

PubMed

Rulifson, Greg; Bielefeldt, Angela R

2018-03-20

Engineers should learn how to act on their responsibility to society during their education. At present, however, it is unknown what students think about the meaning of socially responsible engineering. This paper synthesizes 4 years of longitudinal interviews with engineering students as they progressed through college. The interviews revolved broadly around how students saw the connections between engineering and social responsibility, and what influenced these ideas. Using the Weidman Input-Environment-Output model as a framework, this research found that influences included required classes such as engineering ethics, capstone design, and some technical courses, pre-college volunteering and familial values, co-curricular groups such as Engineers Without Borders and the Society of Women Engineers, as well as professional experiences through internships. Further, some experiences such as technical courses and engineering internships contributed to confine students' understanding of an engineer's social responsibility. Overall, students who stayed in engineering tended to converge on basic responsibilities such as safety and bettering society as a whole, but tended to become less concerned with improving the lives of the marginalized and disadvantaged. Company loyalty also became important for some students. These results have valuable, transferable contributions, providing guidance to foster students' ideas on socially responsible engineering.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pierce, Eric M.; Freshley, Mark D.; Hubbard, Susan S.

In this report, we start by examining previous efforts at linking science and DOE EM research with cleanup activities. Many of these efforts were initiated by creating science and technology roadmaps. A recurring feature of successfully implementing these roadmaps into EM applied research efforts and successful cleanup is the focus on integration. Such integration takes many forms, ranging from combining information generated by various scientific disciplines, to providing technical expertise to facilitate successful application of novel technology, to bringing the resources and creativity of many to address the common goal of moving EM cleanup forward. Successful projects identify and focusmore » research efforts on addressing the problems and challenges that are causing “failure” in actual cleanup activities. In this way, basic and applied science resources are used strategically to address the particular unknowns that are barriers to cleanup. The brief descriptions of the Office of Science basic (Environmental Remediation Science Program [ERSP]) and EM’s applied (Groundwater and Soil Remediation Program) research programs in subsurface science provide context to the five “crosscutting” themes that have been developed in this strategic planning effort. To address these challenges and opportunities, a tiered systematic approach is proposed that leverages basic science investments with new applied research investments from the DOE Office of Engineering and Technology within the framework of the identified basic science and applied research crosscutting themes. These themes are evident in the initial portfolio of initiatives in the EM groundwater and soil cleanup multi-year program plan. As stated in a companion document for tank waste processing (Bredt et al. 2008), in addition to achieving its mission, DOE EM is experiencing a fundamental shift in philosophy from driving to closure to enabling the long-term needs of DOE and the nation.« less

Basic Study on Engine with Scroll Compressor and Expander

NASA Astrophysics Data System (ADS)

Morishita, Etsuo; Kitora, Yoshihisa; Nishida, Mitsuhiro

Scroll compressors are becoming popular in air conditioning and refrigeration. This is primarily due to their higher efficiency and low noise/vibration characteristics. The scroll principle can be applied also to the steam expander and the Brayton cycle engine,as shown in the past literature. The Otto cycle spark-ignition engine with a scroll compressor and expander is studied in this report. The principle and basic structure of the scroll engine are explained,and the engine characteristic are calculated based on the idealized cycles and processes. A prototype model has been proposed and constructed. The rotary type engine has always had a problem with sealing. The scroll engine might overcome this shortcoming with its much lower rubbing speed compared to its previous counterparts,and is therefore worth investigating.

Tissue engineering: state of the art in oral rehabilitation

PubMed Central

SCHELLER, E. L.; KREBSBACH, P. H.; KOHN, D. H.

2009-01-01

SUMMARY More than 85% of the global population requires repair or replacement of a craniofacial structure. These defects range from simple tooth decay to radical oncologic craniofacial resection. Regeneration of oral and craniofacial tissues presents a formidable challenge that requires synthesis of basic science, clinical science and engineering technology. Identification of appropriate scaffolds, cell sources and spatial and temporal signals (the tissue engineering triad) is necessary to optimize development of a single tissue, hybrid organ or interface. Furthermore, combining the understanding of the interactions between molecules of the extracellular matrix and attached cells with an understanding of the gene expression needed to induce differentiation and tissue growth will provide the design basis for translating basic science into rationally developed components of this tissue engineering triad. Dental tissue engineers are interested in regeneration of teeth, oral mucosa, salivary glands, bone and periodontium. Many of these oral structures are hybrid tissues. For example, engineering the periodontium requires growth of alveolar bone, cementum and the periodontal ligament. Recapitulation of biological development of hybrid tissues and interfaces presents a challenge that exceeds that of engineering just a single tissue. Advances made in dental interface engineering will allow these tissues to serve as model systems for engineering other tissues or organs of the body. This review will begin by covering basic tissue engineering principles and strategic design of functional biomaterials. We will then explore the impact of biomaterials design on the status of craniofacial tissue engineering and current challenges and opportunities in dental tissue engineering. PMID:19228277

Tissue engineering: state of the art in oral rehabilitation.

PubMed

Scheller, E L; Krebsbach, P H; Kohn, D H

2009-05-01

More than 85% of the global population requires repair or replacement of a craniofacial structure. These defects range from simple tooth decay to radical oncologic craniofacial resection. Regeneration of oral and craniofacial tissues presents a formidable challenge that requires synthesis of basic science, clinical science and engineering technology. Identification of appropriate scaffolds, cell sources and spatial and temporal signals (the tissue engineering triad) is necessary to optimize development of a single tissue, hybrid organ or interface. Furthermore, combining the understanding of the interactions between molecules of the extracellular matrix and attached cells with an understanding of the gene expression needed to induce differentiation and tissue growth will provide the design basis for translating basic science into rationally developed components of this tissue engineering triad. Dental tissue engineers are interested in regeneration of teeth, oral mucosa, salivary glands, bone and periodontium. Many of these oral structures are hybrid tissues. For example, engineering the periodontium requires growth of alveolar bone, cementum and the periodontal ligament. Recapitulation of biological development of hybrid tissues and interfaces presents a challenge that exceeds that of engineering just a single tissue. Advances made in dental interface engineering will allow these tissues to serve as model systems for engineering other tissues or organs of the body. This review will begin by covering basic tissue engineering principles and strategic design of functional biomaterials. We will then explore the impact of biomaterials design on the status of craniofacial tissue engineering and current challenges and opportunities in dental tissue engineering.

Internal combustion engine with thermochemical recuperation fed by ethanol steam reforming products - feasibility study

NASA Astrophysics Data System (ADS)

Cesana, O.; Gutman, M.; Shapiro, M.; Tartakovsky, L.

2016-08-01

This research analyses the performance of a spark ignition engine fueled by ethanol steam reforming products. The basic concept involves the use of the internal combustion engine's (ICE) waste heat to promote onboard reforming of ethanol. The reformer and the engine performance were simulated and analyzed using GT-Suite, Chem CAD and Matlab software. The engine performance with different compositions of ethanol reforming products was analyzed, in order to find the optimal working conditions of the ICE - reformer system. The analysis performed demonstrated the capability to sustain the endothermic reactions in the reformer and to reform the liquid ethanol to hydrogen-rich gaseous fuel using the heat of the exhaust gases. However, the required reformer's size is quite large: 39 x 89 x 73 cm, which makes a feasibility of its mounting on board a vehicle questionable. A comparison with ICE fed by gasoline or liquid ethanol doesn't show a potential of efficiency improvement, but can be considered as a tool of additional emissions reduction.

Skeletal Muscle Tissue Engineering: Methods to Form Skeletal Myotubes and Their Applications

PubMed Central

Ostrovidov, Serge; Hosseini, Vahid; Ahadian, Samad; Fujie, Toshinori; Parthiban, Selvakumar Prakash; Ramalingam, Murugan; Bae, Hojae; Kaji, Hirokazu

2014-01-01

Skeletal muscle tissue engineering (SMTE) aims to repair or regenerate defective skeletal muscle tissue lost by traumatic injury, tumor ablation, or muscular disease. However, two decades after the introduction of SMTE, the engineering of functional skeletal muscle in the laboratory still remains a great challenge, and numerous techniques for growing functional muscle tissues are constantly being developed. This article reviews the recent findings regarding the methodology and various technical aspects of SMTE, including cell alignment and differentiation. We describe the structure and organization of muscle and discuss the methods for myoblast alignment cultured in vitro. To better understand muscle formation and to enhance the engineering of skeletal muscle, we also address the molecular basics of myogenesis and discuss different methods to induce myoblast differentiation into myotubes. We then provide an overview of different coculture systems involving skeletal muscle cells, and highlight major applications of engineered skeletal muscle tissues. Finally, potential challenges and future research directions for SMTE are outlined. PMID:24320971

Integrated Curriculum Design Reform of Civil Engineering Management Discipline Based on Inter-disciplinary Professional Training

NASA Astrophysics Data System (ADS)

Yidong, Xu; Ping, Wu; Jian, Chen; Jiansheng, Shen

2018-05-01

In view of the shortcomings of the current civil engineering management discipline, this paper investigates the necessity of the course design reform. Based on the analysis of basic occupation requirements of civil engineering management discipline, the basic ideas and implementation strategies of the integrated reform of curriculum design system are proposed, which can not only improve the students’ overall understanding of knowledge and skills, but also enhance the system of student learning.

PREFACE: 6th EEIGM International Conference on Advanced Materials Research

NASA Astrophysics Data System (ADS)

Horwat, David; Ayadi, Zoubir; Jamart, Brigitte

2012-02-01

The 6th EEIGM Conference on Advanced Materials Research (AMR 2011) was held at the European School of Materials Engineering (EEIGM) on the 7-8 November 2011 in Nancy, France. This biennial conference organized by the EEIGM is a wonderful opportunity for all scientists involved in the EEIGM programme, in the 'Erasmus Mundus' Advanced Materials Science and Engineering Master programme (AMASE) and the 'Erasmus Mundus' Doctoral Programme in Materials Science and Engineering (DocMASE), to present their research in the various fields of Materials Science and Engineering. This conference is also open to other universities who have strong links with the EEIGM and provides a forum for the exchange of ideas, co-operation and future orientations by means of regular presentations, posters and a round-table discussion. This edition of the conference included a round-table discussion on composite materials within the Interreg IVA project '+Composite'. Following the publication of the proceedings of AMR 2009 in Volume 5 of this journal, it is with great pleasure that we present this selection of articles to the readers of IOP Conference Series: Materials Science and Engineering. Once again it represents the interdisciplinary nature of Materials Science and Engineering, covering basic and applicative research on organic and composite materials, metallic materials and ceramics, and characterization methods. The editors are indebted to all the reviewers for reviewing the papers at very short notice. Special thanks are offered to the sponsors of the conference including EEIGM-Université de Lorraine, AMASE, DocMASE, Grand Nancy, Ville de Nancy, Region Lorraine, Fédération Jacques Villermaux, Conseil Général de Meurthe et Moselle, Casden and '+Composite'. Zoubir Ayadi, David Horwat and Brigitte Jamart

United States Air Force Summer Research Program -- 1991. High School Apprenticeship Program (HSAP) Reports, Volume 12: Rome Laboratory, Arnold Engineering Development Plan

DTIC Science & Technology

1991-12-01

UNITED STATES AIR FORCE SUMMER RESEARCH PROGRAM -- 19k’ HIGH SCF-0)OL APPRENTICESHIP PROGRAM (HSAP) REtFOC2TS VOLUME 12 ROME LABORATORY ARNOLD...capacity requirements. In the United States and Japan, it has 1.544 Mbps channels (23B+D), and Europe has 2.048 Mbps channels (30B+D). Both are provided over...because of the standard 64 kbps and the layered protocols. Even though the United States and Europe have different primary access channels, the basic

Proceedings of the Meeting of the Coastal Engineering Research Board (44th) Held at Sausalito, California on 4-6 November 1985.

DTIC Science & Technology

1986-04-01

realism here, and I * need to have it from the Board. Federal basic research and development is *simply not a winner. That doesn’t mean we cannot find ways...CERC. The wave height across the surf zone was measured by a cinematic remote sensing technique developed in Japan (Hotta and 82 ....󈨌...8217’" ,’ 1. Mizuguchi, 1980). The cinematic wave measurement method is under study for in.•.. adaptation at CERC where it is called the "photo

Research relative to weather radar measurement techniques

NASA Technical Reports Server (NTRS)

Smith, Paul L.

1992-01-01

Research relative to weather radar measurement techniques, which involves some investigations related to measurement techniques applicable to meteorological radar systems in Thailand, is reported. A major part of the activity was devoted to instruction and discussion with Thai radar engineers, technicians, and meteorologists concerning the basic principles of radar meteorology and applications to specific problems, including measurement of rainfall and detection of wind shear/microburst hazards. Weather radar calibration techniques were also considered during this project. Most of the activity took place during two visits to Thailand, in December 1990 and February 1992.

Automobile Engine: Basic Ignition Timing. Fordson Bilingual Demonstration Project.

ERIC Educational Resources Information Center

Vick, James E.

These two vocational instructional modules on basic automobile ignition timing and on engine operation, four-stroke cycle, are two of eight such modules designed to assist recently arrived Arab students, limited in English proficiency (LEP), in critical instructional areas in a comprehensive high school. Goal stated for this module is for the…

Gasoline Engine Mechanics. Performance Objectives. Basic Course.

ERIC Educational Resources Information Center

Jones, Marion

Several intermediate performance objectives and corresponding criterion measures are listed for each of five terminal objectives presented in this curriculum guide for a basic gasoline engine mechanics course at the secondary level. (For the intermediate course guide see CE 010 946.) The materials were developed for a two semester (2 hours daily)…

1992 NASA/ASEE Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Freeman, L. Michael; Chappell, Charles R.; Six, Frank; Karr, Gerald R.

1992-01-01

For the 28th consecutive year, a NASA/ASEE Summer Faculty Fellowship Program was conducted at the Marshall Space Flight Center (MSFC). The program was conducted by the University of Alabama and MSFC during the period June 1, 1992 through August 7, 1992. Operated under the auspices of the American Society for Engineering Education, the MSFC program, was well as those at other centers, was sponsored by the Office of Educational Affairs, NASA Headquarters, Washington, DC. The basic objectives of the programs, which are the 29th year of operation nationally, are (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate and exchange ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of the participants' institutions; and (4) to contribute to the research objectives of the NASA centers.

Function evaluation of asphalt mixture with industrially produced BOF slag aggregate.

PubMed

Zhao, Meiling; Wu, Shaopeng; Chen, Zongwu; Li, Chao

2016-07-04

Laboratory research suggested that basic oxygen furnace (BOF) slag-based asphalt mixture was a functional material. However, the BOF slag aggregate's quality was difficult to control when it was heavily used in entity engineering. The primary objective of this research was to evaluate the functional performances of asphalt mixture containing BOF slag coarse aggregate (BSCA), which was from an industrialized production line. Limestone mixture was a control group. The Marshall method was first adopted to design asphalt mixtures. The performances of limestone asphalt mixture and BOF slag asphalt mixture including fatigue failure resistance and moisture stability were then evaluated and compared. Results showed that the asphalt mixture containing BSCA possessed better durability, which meant the quality of BSCA from industrialized production lines was well controlled and this BSCA can be heavily used in entity engineering.

Tissue-engineered vascularized bone grafts: basic science and clinical relevance to trauma and reconstructive microsurgery.

PubMed

Johnson, Elizabeth O; Troupis, Theodore; Soucacos, Panayotis N

2011-03-01

Bone grafts are an important part of orthopaedic surgeon's armamentarium. Despite well-established bone-grafting techniques, large bone defects still represent a challenge. Efforts have therefore been made to develop osteoconductive, osteoinductive, and osteogenic bone-replacement systems. The long-term clinical goal in bone tissue engineering is to reconstruct bony tissue in an anatomically functional three-dimensional morphology. Current bone tissue engineering strategies take into account that bone is known for its ability to regenerate following injury, and for its intrinsic capability to re-establish a complex hierarchical structure during regeneration. Although the tissue engineering of bone for the reconstruction of small to moderate sized bone defects technically feasible, the reconstruction of large defects remains a daunting challenge. The essential steps towards optimized clinical application of tissue-engineered bone are dependent upon recent advances in the area of neovascularization of the engineered construct. Despite these recent advances, however, a gap from bench to bedside remains; this may ultimately be bridged by a closer collaboration between basic scientists and reconstructive surgeons. The aim of this review is to introduce the basic principles of tissue engineering of bone, outline the relevant bone physiology, and discuss the recent concepts for the induction of vascularization in engineered bone tissue. Copyright © 2011 Wiley-Liss, Inc.

Development of a Dynamically Configurable,Object-Oriented Framework for Distributed, Multi-modal Computational Aerospace Systems Simulation

NASA Technical Reports Server (NTRS)

Afjeh, Abdollah A.; Reed, John A.

2003-01-01

This research is aimed at developing a neiv and advanced simulation framework that will significantly improve the overall efficiency of aerospace systems design and development. This objective will be accomplished through an innovative integration of object-oriented and Web-based technologies ivith both new and proven simulation methodologies. The basic approach involves Ihree major areas of research: Aerospace system and component representation using a hierarchical object-oriented component model which enables the use of multimodels and enforces component interoperability. Collaborative software environment that streamlines the process of developing, sharing and integrating aerospace design and analysis models. . Development of a distributed infrastructure which enables Web-based exchange of models to simplify the collaborative design process, and to support computationally intensive aerospace design and analysis processes. Research for the first year dealt with the design of the basic architecture and supporting infrastructure, an initial implementation of that design, and a demonstration of its application to an example aircraft engine system simulation.

Yang-Baxter deformations of supercoset sigma models with ℤ4m grading

NASA Astrophysics Data System (ADS)

Ke, San-Min; Yang, Wen-Li; Jang, Ke-Xia; Wang, Chun; Shuai, Xue-Min; Wang, Zhan-Yun; Shi, Gang

2017-11-01

We have studied Yang-Baxter deformations of supercoset sigma models with ℤ4m grading. The deformations are specified by a skew-symmetric classical r-matrix satisfying the classical Yang-Baxter equations. The deformed action is constructed and the Lax pair is also presented. When m=1, our results reduce to those of the type IIB Green-Schwarz superstring on AdS 5×S 5 background recently given by Kawaguchi, Matsumoto and Yoshida. Supported by National Natural Science Foundation of China (11375141, 11425522, 11547050), Natural Science Foundation of Shaanxi Province (2013JQ1011, 2017ZDJC-32, 2016JM1027), Special Foundation for Basic Scientific Research of Central Colleges (310812152001, 310812172001, 2013G1121082, CHD2012JC019), Scientific Research Program Funded by Shaanxi Provincial Education Department (2013JK0628), Xi’an Shiyou University Science and Technology Foundation (2010QN018) and partly supported by the Basic Research Foundation of Engineering University of CAPF (WJY-201506)

Fusion Studies in Japan

NASA Astrophysics Data System (ADS)

Ogawa, Yuichi

2016-05-01

A new strategic energy plan decided by the Japanese Cabinet in 2014 strongly supports the steady promotion of nuclear fusion development activities, including the ITER project and the Broader Approach activities from the long-term viewpoint. Atomic Energy Commission (AEC) in Japan formulated the Third Phase Basic Program so as to promote an experimental fusion reactor project. In 2005 AEC has reviewed this Program, and discussed on selection and concentration among many projects of fusion reactor development. In addition to the promotion of ITER project, advanced tokamak research by JT-60SA, helical plasma experiment by LHD, FIREX project in laser fusion research and fusion engineering by IFMIF were highly prioritized. Although the basic concept is quite different between tokamak, helical and laser fusion researches, there exist a lot of common features such as plasma physics on 3-D magnetic geometry, high power heat load on plasma facing component and so on. Therefore, a synergetic scenario on fusion reactor development among various plasma confinement concepts would be important.

Electrophoresis experiments in microgravity

NASA Technical Reports Server (NTRS)

Snyder, Robert S.; Rhodes, Percy H.

1991-01-01

The use of the microgravity environment to separate and purify biological cells and proteins has been a major activity since the beginning of the NASA Microgravity Science and Applications program. Purified populations of cells are needed for research, transplantation and analysis of specific cell constituents. Protein purification is a necessary step in research areas such as genetic engineering where the new protein has to be separated from the variety of other proteins synthesized from the microorganism. Sufficient data are available from the results of past electrophoresis experiments in space to show that these experiments were designed with incomplete knowledge of the fluid dynamics of the process including electrohydrodynamics. However, electrophoresis is still an important separation tool in the laboratory and thermal convection does limit its performance. Thus, there is a justification for electrophoresis but the emphasis of future space experiments must be directed toward basic research with model experiments to understand the microgravity environment and fluid analysis to test the basic principles of the process.

40 CFR 1048.205 - What must I include in my application?

Code of Federal Regulations, 2014 CFR

2014-07-01

... POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, LARGE NONROAD SPARK-IGNITION ENGINES Certifying Engine...'s specifications and other basic parameters of the engine's design and emission controls. List the... each distinguishable engine configuration in the engine family. (b) Explain how the emission control...

40 CFR 1048.205 - What must I include in my application?

Code of Federal Regulations, 2013 CFR

2013-07-01

... POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, LARGE NONROAD SPARK-IGNITION ENGINES Certifying Engine...'s specifications and other basic parameters of the engine's design and emission controls. List the... each distinguishable engine configuration in the engine family. (b) Explain how the emission control...

Seeing through the lens of social justice: A threshold for engineering

NASA Astrophysics Data System (ADS)

Kabo, Jens David

In recent times the need for educational research dedicated to engineering education has been recognised. This PhD project is a contribution to the development of engineering education scholarship and the growing body of engineering education research. In this project it was recognised that problem solving is a central activity to engineering. However, it was also recognised that the conditions for doing engineering are changing, especially in light of pressing issues of poverty and environmental sustainability that humanity currently faces, and as a consequence, engineering education needs to emphasise problem definition to a greater extent. One mechanism for achieving this, which has been adopted by some engineering educators in recent years, is through courses that explicitly relate engineering to social justice. However, creating this relationship requires critical interdisciplinary thinking that is alien to most engineering students. In this dissertation it is suggested that for engineering students, and more generally, engineers, looking at their practice and profession through a social justice lens might be seen as a threshold that needs to be crossed. By studying the variation present among students in three different courses at three different North American universities, the intention was to understand how students approach and internalise social justice as a perspective on engineering and/or develop their abilities to think critically. A conceptual model to frame the study was developed by combining elements of threshold concept theory and the educational research methodology, phenomenographic variation theory. All three of the courses studied operated on a similar basic pedagogical model, however, the courses were framed differently, with social justice in the foreground or in the background with the focus on, in one case, ethics and in the other, sustainability. All courses studied appeared to be successful in encouraging engineering students to engage in critical thinking and a similar general trend in the development of students' conceptions of social justice was observed in each of the three courses. However, it does appear that if one is interested in developing an articulated understanding of social justice, with respect to engineering, that an explicit focus on social justice is preferable.

Extending Cross-Generational Knowledge Flow Research in Edge Organizations

DTIC Science & Technology

2008-06-01

letting Protégé generate the basic user interface, and then gradually write widgets and plug-ins to customize its look-and- feel and behavior . 4 3.0...2007a) focused on cross-generational knowledge flows in edge organizations. We found that cross- generational biases affect tacit knowledge transfer...the software engineering field, many matured methodologies already exist, such as Rational Unified Process (Hunt, 2003) or Extreme Programming (Beck

A model for international border management systems.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Duggan, Ruth Ann

2008-09-01

To effectively manage the security or control of its borders, a country must understand its border management activities as a system. Using its systems engineering and security foundations as a Department of Energy National Security Laboratory, Sandia National Laboratories has developed such an approach to modeling and analyzing border management systems. This paper describes the basic model and its elements developed under Laboratory Directed Research and Development project 08-684.

Automatic satellite capture and berthing with robot arm (ASCABRA)

NASA Technical Reports Server (NTRS)

Inaba, Noriyasu; Wakabayashi, Yasufumi; Iijima, Takahiko

1994-01-01

The NASDA office of R&D is studying an automatic technique to capture and berth free-floating satellites using a robot arm on another satellite. A demonstration experiment plan with the Japanese engineering test satellite ETS-7 is being developed based on the basic research on the ground. The overview and key technologies of this experiment plan are presented, and future applications of the automatic capture technique are also reviewed.

Investigating the Fundamental Scientific Issues Affecting the Long-term Geologic Storage of Carbon Dioxide

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spangler, Lee; Cunningham, Alfred; Barnhart, Elliot

2014-12-19

The Zero Emissions Research and Technology (ZERT) collaborative was formed to address basic science and engineering knowledge gaps relevant to geologic carbon sequestration. The original funding round of ZERT (ZERT I) identified and addressed many of these gaps. ZERT II has focused on specific science and technology areas identified in ZERT I that showed strong promise and needed greater effort to fully develop.

On fundamentally new sources of energy for rockets in the early works of the pioneers of astronautics

NASA Technical Reports Server (NTRS)

Melkumov, T. M.

1977-01-01

The research for more efficient methods of propelling a spacecraft, than can be achieved with chemical energy, was studied. During a time when rockets for space flight had not actually been built pioneers in rocket technology were already concerned with this problem. Alternative sources proposed at that time, were nuclear and solar energy. Basic engineering problems of each source were investigated.

Magnetic Excitations and Geometric Confinement; Theory and simulations

NASA Astrophysics Data System (ADS)

Wysin, Gary Matthew

2015-12-01

In this book, author Gary Wysin provides an overview of model systems and their behaviour and effects, and is intended for advanced students and researchers in physics, chemistry and engineering interested in confined magnetics. It is also suitable as an auxiliary text in a class on magnetism or solid state physics. Previous physics knowledge is expected, along with some basic knowledge of classical electromagnetism and electromagnetic waves for the latter chapters.

A Novel Multi-Finger Gate Structure of AlGaN/GaN High Electron Mobility Transistor

NASA Astrophysics Data System (ADS)

Cui, Lei; Wang, Quan; Wang, Xiao-Liang; Xiao, Hong-Ling; Wang, Cui-Mei; Jiang, Li-Juan; Feng, Chun; Yin, Hai-Bo; Gong, Jia-Min; Li, Bai-Quan; Wang, Zhan-Guo

2015-05-01

Not Available Supported by the Knowledge Innovation Engineering of the Chinese Academy of Sciences under Grant No YYY-0701-02, the National Nature Science Foundation of China under Grant Nos 61106014, 61204017 and 61334002, the State Key Development Program for Basic Research of China under Grant No 2010CB327503, and the National Science and Technology Major Project of China.

Experimental characterization of a small custom-built double-acting gamma-type stirling engine

NASA Astrophysics Data System (ADS)

Intsiful, Peter; Mensah, Francis; Thorpe, Arthur

This paper investigates characterization of a small custom-built double-acting gamma-type stirling engine. Stirling-cycle engine is a reciprocating energy conversion machine with working spaces operating under conditions of oscillating pressure and flow. These conditions may be due to compressibility as wells as pressure and temperature fluctuations. In standard literature, research indicates that there is lack of basic physics to account for the transport phenomena that manifest themselves in the working spaces of reciprocating engines. Previous techniques involve governing equations: mass, momentum and energy. Some authors use engineering thermodynamics. None of these approaches addresses this particular engine. A technique for observing and analyzing the behavior of this engine via parametric spectral profiles has been developed, using laser beams. These profiles enabled the generation of pv-curves and other trajectories for investigating the thermos-physical and thermos-hydrodynamic phenomena that manifest in the exchangers. The engine's performance was examined. The results indicate that with current load of 35.78A, electric power of 0.505 kW was generated at a speed of 240 rpm and 29.50 percent efficiency was obtained. Nasa grants to Howard University NASA/HBCU-NHRETU & CSTEA.

Stratified charge rotary engine combustion studies

NASA Technical Reports Server (NTRS)

Shock, H.; Hamady, F.; Somerton, C.; Stuecken, T.; Chouinard, E.; Rachal, T.; Kosterman, J.; Lambeth, M.; Olbrich, C.

1989-01-01

Analytical and experimental studies of the combustion process in a stratified charge rotary engine (SCRE) continue to be the subject of active research in recent years. Specifically to meet the demand for more sophisticated products, a detailed understanding of the engine system of interest is warranted. With this in mind the objective of this work is to develop an understanding of the controlling factors that affect the SCRE combustion process so that an efficient power dense rotary engine can be designed. The influence of the induction-exhaust systems and the rotor geometry are believed to have a significant effect on combustion chamber flow characteristics. In this report, emphasis is centered on Laser Doppler Velocimetry (LDV) measurements and on qualitative flow visualizations in the combustion chamber of the motored rotary engine assembly. This will provide a basic understanding of the flow process in the RCE and serve as a data base for verification of numerical simulations. Understanding fuel injection provisions is also important to the successful operation of the stratified charge rotary engine. Toward this end, flow visualizations depicting the development of high speed, high pressure fuel jets are described. Friction is an important consideration in an engine from the standpoint of lost work, durability and reliability. MSU Engine Research Laboratory efforts in accessing the frictional losses associated with the rotary engine are described. This includes work which describes losses in bearing, seal and auxillary components. Finally, a computer controlled mapping system under development is described. This system can be used to map shapes such as combustion chamber, intake manifolds or turbine blades accurately.

Stratified charge rotary engine combustion studies

NASA Astrophysics Data System (ADS)

Shock, H.; Hamady, F.; Somerton, C.; Stuecken, T.; Chouinard, E.; Rachal, T.; Kosterman, J.; Lambeth, M.; Olbrich, C.

1989-07-01

Analytical and experimental studies of the combustion process in a stratified charge rotary engine (SCRE) continue to be the subject of active research in recent years. Specifically to meet the demand for more sophisticated products, a detailed understanding of the engine system of interest is warranted. With this in mind the objective of this work is to develop an understanding of the controlling factors that affect the SCRE combustion process so that an efficient power dense rotary engine can be designed. The influence of the induction-exhaust systems and the rotor geometry are believed to have a significant effect on combustion chamber flow characteristics. In this report, emphasis is centered on Laser Doppler Velocimetry (LDV) measurements and on qualitative flow visualizations in the combustion chamber of the motored rotary engine assembly. This will provide a basic understanding of the flow process in the RCE and serve as a data base for verification of numerical simulations. Understanding fuel injection provisions is also important to the successful operation of the stratified charge rotary engine. Toward this end, flow visualizations depicting the development of high speed, high pressure fuel jets are described. Friction is an important consideration in an engine from the standpoint of lost work, durability and reliability. MSU Engine Research Laboratory efforts in accessing the frictional losses associated with the rotary engine are described. This includes work which describes losses in bearing, seal and auxillary components. Finally, a computer controlled mapping system under development is described. This system can be used to map shapes such as combustion chamber, intake manifolds or turbine blades accurately.

Start Your Engines: Surfing with Search Engines for Kids.

ERIC Educational Resources Information Center

Byerly, Greg; Brodie, Carolyn S.

1999-01-01

Suggests that to be an effective educator and user of the Web it is essential to know the basics about search engines. Presents tips for using search engines. Describes several search engines for children and young adults, as well as some general filtered search engines for children. (AEF)

Fuel control for gas turbine engines

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stearns, C.F.; Tutherly, H.W.

1983-12-27

The basic gas turbine engine hydromechanical fuel control is adaptable to different engine configurations such as turbofan, turboprop and turboshaft engines by incorporating in the main housing those elements having a commonality to all engine configurations and providing a removable block for each configuration having the necessary control elements and flow passages required for that particular configuration. That is to say, a block with the elements peculiar to a turbofan engine could be replaced by a mating block that includes those elements peculiar to a turboshaft engine in adapting the control for a turboshaft configuration. Similarly another block with thosemore » elements peculiar to a turboprop engine could replace any of the other blocks in adapting the control to a turboprop configuration. Obviously the basic control has the necessary flow passages terminating at the interface with the block and these flow passages mate with corresponding passages in the block.« less

Multi-University Southeast INIE Consortium

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ayman Hawari; Nolan Hertel; Mohamed Al-Sheikhly

2 Project Summary: The Multi-University Southeast INIE Consortium (MUSIC) was established in response to the US Department of Energy’s (DOE) Innovations in Nuclear Infrastructure and Education (INIE) program. MUSIC was established as a consortium composed of academic members and national laboratory partners. The members of MUSIC are the nuclear engineering programs and research reactors of Georgia Institute of Technology (GIT), North Carolina State University (NCSU), University of Maryland (UMD), University of South Carolina (USC), and University of Tennessee (UTK). The University of Florida (UF), and South Carolina State University (SCSU) were added to the MUSIC membership in the second year.more » In addition, to ensure proper coordination between the academic community and the nation’s premier research and development centers in the fields of nuclear science and engineering, MUSIC created strategic partnerships with Oak Ridge National Laboratory (ORNL) including the Spallation Neutron Source (SNS) project and the Joint Institute for Neutron Scattering (JINS), and the National Institute of Standards and Technology (NIST). A partnership was also created with the Armed Forces Radiobiology Research Institute (AFRRI) with the aim of utilizing their reactor in research if funding becomes available. Consequently, there are three university research reactors (URRs) within MUSIC, which are located at NCSU (1-MW PULSTAR), UMD (0.25-MW TRIGA) and UF (0.10-MW Argonaut), and the AFRRI reactor (1-MW TRIGA MARK F). The overall objectives of MUSIC are: a) Demonstrate that University Research Reactors (URR) can be used as modern and innovative instruments of research in the basic and applied sciences, which include applications in fundamental physics, materials science and engineering, nondestructive examination, elemental analysis, and contributions to research in the health and medical sciences, b) Establish a strong technical collaboration between the nuclear engineering faculty and the MUSIC URRs. This will be achieved by involving the faculty in the development of state-of-the-art research facilities at the URRs and subsequently, in the utilization of these facilities, c) Facilitate the use of the URRs by the science and engineering faculty within the individual institutions and by the general community of science and engineering, d) Develop a far-reaching educational component that is capable of addressing the needs of the nuclear science and engineering community. Specifically, the aim of this component will be to perform public outreach activities, contribute to the active recruitment of the next generation of nuclear professionals, strengthen the education of nuclear engineering students, and promote nuclear engineering education for minority students.« less

Renewable energy technology from underpinning physics to engineering application

NASA Astrophysics Data System (ADS)

Infield, D. G.

2008-03-01

The UK Energy Research Centre (UKERC) in it's submission to the DTI's 2006 Energy Review reminded us that the ''UK has abundant wind, wave and tidal resources available; its mild climate lends itself to bio-energy production, and solar radiation levels are sufficient to sustain a viable solar industry''. These technologies are at different stages of development but they all draw on basic and applied Science and Engineering. The paper will briefly review the renewable energy technologies and their potential for contributing to a sustainable energy supply. Three research topics will be highlighted that bridge the gap between the physics underpinning the energy conversion, and the engineering aspects of development and deployment; all three are highly relevant to the Government's programme on micro-generation. Two are these are taken from field of thin film photovoltaics (PV), one related to novel device development and the other to a measurement technique for assessing the manufacturing quality of PV modules and their performance. The third topic concerns the development of small building integrated wind turbines and examines the complex flow associated with such applications. The paper will conclude by listing key research challenges that are central to the search for efficient and cost-effective renewable energy generation.

A Validity and Reliability Study of the Basic Electronics Skills Self-Efficacy Scale (BESS)

ERIC Educational Resources Information Center

Korkmaz, Ö.; Korkmaz, M. K.

2016-01-01

The aim of this study is to improve a measurement tool to evaluate the self-efficacy of Electrical-Electronics Engineering students through their basic electronics skills. The sample group is composed of 124 Electrical-Electronics engineering students. The validity of the scale is analyzed with two different methods through factor analysis and…

Coherent Teaching and Need-Based Learning in Science: An Approach to Teach Engineering Students in Basic Physics Courses

ERIC Educational Resources Information Center

Kurki-Suonio, T.; Hakola, A.

2007-01-01

In the present paper, we propose an alternative, based on constructivism, to the conventional way of teaching basic physics courses at the university level. We call this approach "coherent teaching" and the underlying philosophy of teaching science and engineering "need-based learning". We have been applying this philosophy in…

A Researcher's Guide to Mass Spectrometry-Based Proteomics

PubMed Central

Savaryn, John P.; Toby, Timothy K.; Kelleher, Neil L.

2016-01-01

Mass spectrometry (MS) is widely recognized as a powerful analytical tool for molecular research. MS is used by researchers around the globe to identify, quantify, and characterize biomolecules like proteins from any number of biological conditions or sample types. As instrumentation has advanced, and with the coupling of liquid chromatography (LC) for high-throughput LC-MS/MS, a proteomics experiment measuring hundreds to thousands of proteins/protein groups is now commonplace. While expert practitioners who best understand the operation of LC-MS systems tend to have strong backgrounds in physics and engineering, consumers of proteomics data and technology are not exposed to the physio-chemical principles underlying the information they seek. Since articles and reviews tend not to focus on bridging this divide, our goal here is to span this gap and translate MS ion physics into language intuitive to the general reader active in basic or applied biomedical research. Here, we visually describe what happens to ions as they enter and move around inside a mass spectrometer. We describe basic MS principles, including electric current, ion optics, ion traps, quadrupole mass filters, and Orbitrap FT-analyzers. PMID:27553853

NASA-UVA light aerospace alloy and structures technology program (LA2ST)

NASA Technical Reports Server (NTRS)

Gangloff, Richard P.

1992-01-01

The NASA-UVa Light Aerospace Alloy and Structure Technology (LAST) Program continues to maintain a high level of activity, with projects being conducted by graduate students and faculty advisors in the Departments of Materials Science and Engineering, Civil Engineering and Applied Mechanics, and Mechanical and Aerospace Engineering at the University of Virginia. This work is funded by the NASA-Langley Research Center under Grant NAG-1-745. Here, we report on progress achieved between January 1 and June 30, 1992. The objectives of the LA2ST Program is to conduct interdisciplinary graduate student research on the performance of the next generation, light weight aerospace alloys, composites and thermal gradient structures in collaboration with Langley researchers. Technical objectives are established for each research project. We aim to produce relevant data and basic understanding of material mechanical response, corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; new solid and fluid mechanics analyses; measurement advances; and critically, a pool of educated graduate students for aerospace technologies. The accomplishments presented in this report cover topics including: (1) Mechanical and Environmental Degradation Mechanisms in Advance Light Metals and Composites; (2) Aerospace Materials Science; (3) Mechanics of Materials and Composites for Aerospace Structures; and (4) Thermal Gradient Structures.

The use of fish models to study human neurological disorders.

PubMed

Matsui, Hideaki

2017-07-01

Small teleost fish including zebrafish and medaka have been used as animal models in basic science research due to the relative ease of handling and transparency during embryogenesis. Current advances in genetic engineering and progress in disease genetics allowed utilization of these fish to study neurological diseases and psychiatric disorders. This review summarizes the advantages and disadvantages of using fish for neuropsychiatric research using primarily our own studies as examples. We discuss how fish belong to a class of vertebrates, are feasible for imaging, and include diverse species with multiple research possibilities yet to be discovered. Copyright © 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.

Chemical research projects office functions accomplishments programs. [applied research in the fields of polymer chemistry and polymeric composites with emphasis on fire safety

NASA Technical Reports Server (NTRS)

Heimbuch, A. H.; Parker, J. A.

1975-01-01

Basic and applied research in the fields of polymer chemistry, polymeric composites, chemical engineering, and biophysical chemistry is summarized. Emphasis is placed on fire safety and human survivability as they relate to commercial and military aircraft, high-rise buildings, mines and rapid transit transportation. Materials systems and other fire control systems developed for aerospace applications and applied to national domestic needs are described along with bench-scale and full-scale tests conducted to demonstrate the improvements in performance obtained through the utilization of these materials and fire control measures.

Research progress on expansive soil cracks under changing environment.

PubMed

Shi, Bei-xiao; Zheng, Cheng-feng; Wu, Jin-kun

2014-01-01

Engineering problems shunned previously rise to the surface gradually with the activities of reforming the natural world in depth, the problem of expansive soil crack under the changing environment becoming a control factor of expansive soil slope stability. The problem of expansive soil crack has gradually become a research hotspot, elaborates the occurrence and development of cracks from the basic properties of expansive soil, and points out the role of controlling the crack of expansive soil strength. We summarize the existing research methods and results of expansive soil crack characteristics. Improving crack measurement and calculation method and researching the crack depth measurement, statistical analysis method, crack depth and surface feature relationship will be the future direction.

Nuclear fission: the interplay of science and technology.

PubMed

Stoneham, A M

2010-07-28

When the UK's Calder Hall nuclear power station was connected to the grid in 1956, the programmes that made this possible involved a powerful combination of basic and applied research. Both the science and the engineering were novel, addressing new and challenging problems. That the last Calder Hall reactor was shut down only in 2003 attests to the success of the work. The strengths of bringing basic science to bear on applications continued to be recognized until the 1980s, when government and management fashions changed. This paper identifies a few of the technology challenges, and shows how novel basic science emerged from them and proved essential in their resolution. Today, as the threat of climate change becomes accepted, it has become clear that there is no credible solution without nuclear energy. The design and construction of new fission reactors will need continuing innovation, with the interplay between the science and technology being a crucial component.

Research on rebuilding the data information environment for aeronautical manufacturing enterprise

NASA Astrophysics Data System (ADS)

Feng, Xilan; Jiang, Zhiqiang; Zong, Xuewen; Shi, Jinfa

2005-12-01

The data environment on integrated information system and the basic standard on information resource management are the key effectively of the remote collaborative designing and manufacturing for complex product. A study project on rebuilding the data information environment for aeronautical manufacturing enterprise (Aero-ME) is put forwarded. Firstly, the data environment on integrated information system, the basic standard on information resource management, the basic establishment on corporation's information, the development on integrated information system, and the information education are discussed profoundly based on the practical requirement of information resource and technique for contemporary Aero-ME. Then, the idea and method with the data environment rebuilding based on I-CASE in the corporation is put forward, and the effective method and implement approach for manufacturing enterprise information is brought forwards. It will also the foundation and assurance that rebuilding the corporation data-environment and promoting standardizing information resource management for the development of Aero-ME information engineering.

Dual-fuel, dual-throat engine preliminary analysis

NASA Technical Reports Server (NTRS)

Obrien, C. J.

1979-01-01

A propulsion system analysis of the dual fuel, dual throat engine for launch vehicle applications was conducted. Basic dual throat engine characterization data were obtained to allow vehicle optimization studies to be conducted. A preliminary baseline engine system was defined.

This photo shows a head-on view of NASA's SR-71B on the ramp at the Air Force's Plant 42 in Palmdale, California, shortly before delivery to DFRC

NASA Image and Video Library

1991-07-24

This photo shows a head-on view of NASA's SR-71B, used for pilot proficiency and training, on the ramp at the Air Force's Plant 42 in Palmdale, California, shortly before delivery to the Ames-Dryden Flight Research Facility (later, Dryden Flight Research Center) at Edwards, California. NASA operated two of these unique aircraft, an SR-71A, for high-speed, high altitude research, and this SR- 71B pilot trainer for most of the decade of the 1990s. The "B" model is special because of its raised rear cockpit, which provided a second pilot position so a trainer and an experienced pilot could both see what was going on during flights. The SR-71 was designed and built by the Lockheed Skunk Works, now the Lockheed Martin Skunk Works. Studies have shown that less than 20 percent of the total thrust used to fly at Mach 3 is produced by the basic engine itself. The balance of the total thrust is produced by the unique design of the engine inlet and "moveable spike" system at the front of the engine nacelles, and by the ejector nozzles at the exhaust which burn air compressed in the engine bypass system. Data from the SR-71 high speed research program will be used to aid designers of future supersonic/hypersonic aircraft and propulsion systems, including a high speed civil transport.

Using a Low Cost Flight Simulation Environment for Interdisciplinary Education

NASA Technical Reports Server (NTRS)

Khan, M. Javed; Rossi, Marcia; ALi, Syed F.

2004-01-01

A multi-disciplinary and inter-disciplinary education is increasingly being emphasized for engineering undergraduates. However, often the focus is on interaction between engineering disciplines. This paper discusses the experience at Tuskegee University in providing interdisciplinary research experiences for undergraduate students in both Aerospace Engineering and Psychology through the utilization of a low cost flight simulation environment. The environment, which is pc-based, runs a low-cost of-the-shelf software and is configured for multiple out-of-the-window views and a synthetic heads down display with joystick, rudder and throttle controls. While the environment is being utilized to investigate and evaluate various strategies for training novice pilots, students were involved to provide them with experience in conducting such interdisciplinary research. On the global inter-disciplinary level these experiences included developing experimental designs and research protocols, consideration of human participant ethical issues, and planning and executing the research studies. During the planning phase students were apprised of the limitations of the software in its basic form and the enhancements desired to investigate human factors issues. A number of enhancements to the flight environment were then undertaken, from creating Excel macros for determining the performance of the 'pilots', to interacting with the software to provide various audio/video cues based on the experimental protocol. These enhancements involved understanding the flight model and performance, stability & control issues. Throughout this process, discussions of data analysis included a focus from a human factors perspective as well as an engineering point of view.

Integrating utilization-focused evaluation with business process modeling for clinical research improvement.

PubMed

Kagan, Jonathan M; Rosas, Scott; Trochim, William M K

2010-10-01

New discoveries in basic science are creating extraordinary opportunities to design novel biomedical preventions and therapeutics for human disease. But the clinical evaluation of these new interventions is, in many instances, being hindered by a variety of legal, regulatory, policy and operational factors, few of which enhance research quality, the safety of study participants or research ethics. With the goal of helping increase the efficiency and effectiveness of clinical research, we have examined how the integration of utilization-focused evaluation with elements of business process modeling can reveal opportunities for systematic improvements in clinical research. Using data from the NIH global HIV/AIDS clinical trials networks, we analyzed the absolute and relative times required to traverse defined phases associated with specific activities within the clinical protocol lifecycle. Using simple median duration and Kaplan-Meyer survival analysis, we show how such time-based analyses can provide a rationale for the prioritization of research process analysis and re-engineering, as well as a means for statistically assessing the impact of policy modifications, resource utilization, re-engineered processes and best practices. Successfully applied, this approach can help researchers be more efficient in capitalizing on new science to speed the development of improved interventions for human disease.

Mass drivers. 3: Engineering

NASA Technical Reports Server (NTRS)

Arnold, W.; Bowen, S.; Cohen, S.; Fine, K.; Kaplan, D.; Kolm, M.; Kolm, H.; Newman, J.; Oneill, G. K.; Snow, W.

1979-01-01

The last of a series of three papers by the Mass-Driver Group of the 1977 Ames Summer Study is presented. It develops the engineering principles required to implement the basic mass-driver. Optimum component mass trade-offs are derived from a set of four input parameters, and the program used to design a lunar launcher. The mass optimization procedures is then incorporated into a more comprehensive mission optimization program called OPT-4, which evaluates an optimized mass-driver reaction engine and its performance in a range of specified missions. Finally, this paper discusses, to the extent that time permitted, certain peripheral problems: heating effects in buckets due to magnetic field ripple; an approximate derivation of guide force profiles; the mechanics of inserting and releasing payloads; the reaction mass orbits; and a proposed research and development plan for implementing mass drivers.

Engineering Large Animal Species to Model Human Diseases.

PubMed

Rogers, Christopher S

2016-07-01

Animal models are an important resource for studying human diseases. Genetically engineered mice are the most commonly used species and have made significant contributions to our understanding of basic biology, disease mechanisms, and drug development. However, they often fail to recreate important aspects of human diseases and thus can have limited utility as translational research tools. Developing disease models in species more similar to humans may provide a better setting in which to study disease pathogenesis and test new treatments. This unit provides an overview of the history of genetically engineered large animals and the techniques that have made their development possible. Factors to consider when planning a large animal model, including choice of species, type of modification and methodology, characterization, production methods, and regulatory compliance, are also covered. © 2016 by John Wiley & Sons, Inc. Copyright © 2016 John Wiley & Sons, Inc.

Boehringer Mannheim award lecture 1995. La conference Boehringer Mannheim 1995. De novo design of alpha-helical proteins: basic research to medical applications.

PubMed

Hodges, R S

1996-01-01

The two-stranded alpha-helical coiled-coil is a universal dimerization domain used by nature in a diverse group of proteins. The simplicity of the coiled-coil structure makes it an ideal model system to use in understanding the fundamentals of protein folding and stability and in testing the principles of de novo design. The issues that must be addressed in the de novo design of coiled-coils for use in research and medical applications are (i) controlling parallel versus antiparallel orientation of the polypeptide chains, (ii) controlling the number of helical strands in the assembly (iii) maximizing stability of homodimers or heterodimers in the shortest possible chain length that may require the engineering of covalent constraints, and (iv) the ability to have selective heterodimerization without homodimerization, which requires a balancing of selectivity versus affinity of the dimerization strands. Examples of our initial inroads in using this de novo design motif in various applications include: heterodimer technology for the detection and purification of recombinant peptides and proteins; a universal dimerization domain for biosensors; a two-stage targeting and delivery system; and coiled-coils as templates for combinatorial helical libraries for basic research and drug discovery and as synthetic carrier molecules. The universality of this dimerization motif in nature suggests an endless number of possibilities for its use in de novo design, limited only by the creativity of peptide-protein engineers.

NASA-UVA light aerospace alloy and structures technology program (LA2ST)

NASA Technical Reports Server (NTRS)

Starke, Edgar A., Jr.; Gangloff, Richard P.; Herakovich, Carl T.; Scully, John R.; Shiflet, Gary J.; Stoner, Glenn E.; Wert, John A.

1995-01-01

The NASA-UVa Light Aerospace Alloy and Structures Technology (LA2ST) Program was initiated in 1986 and continues with a high level of activity. Projects are being conducted by graduate students and faculty advisors in the Department of Materials Science and Engineering, as well as in the Department of Civil Engineering and Applied Mechanics, at the University of Virginia. Here, we report on progress achieved between July 1 and December 31, 1994. The objective of the LA2ST Program is to conduct interdisciplinary graduate student research on the performance of next generation, light-weight aerospace alloys, composites and thermal gradient structures in collaboration with NASA-Langley researchers. Specific technical objectives are presented for each research project. We generally aim to produce relevant data and basic understanding of material mechanical response, environmental/corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; new solid and fluid mechanics analyses; measurement and modeling advances; and a pool of educated graduate students for aerospace technologies.

The Shock and Vibration Bulletin. Part 3. Invited Papers, Pyrotechnic Shock, Pyrotechnic Shock Workshop

DTIC Science & Technology

1986-08-01

Technology Laboratory, Watertown, MA AIR FORCE BASIC RESEARCH IN DYNAMICS AND CONTROL OF LARGE SPACE STRUCTURES Anthony K. Amos, Boiling Air Force Base...Engineering, Watchun$, NJ TEMPERATURE SHIFT CONSIDERATIONS FOR DAMPING MATERIALS L. Rogers, Air Force Wright Aeronautictl Laboratories, Wright...INDUCED CAVITY ACOUSTICS L.L. Shaw,. Air Force Wr4ht Aeroaauical Laborawrics, Wri•ht-Paucswon AFB. OH i 4i SESSION CHAIRMEN AND COCHAIRMEN 56th Shock and

Building Bridges: Leveraging Interdisciplinary Collaborations in the Development of Biomaterials to Meet Clinical Needs

PubMed Central

Fong, Eliza L.S.; Watson, Brendan M.; Kasper, F. Kurtis

2013-01-01

Our laboratory at Rice University has forged numerous collaborations with clinicians and basic scientists over the years to advance the development of novel biomaterials and modification of existing materials to meet clinical needs. This review highlights collaborative advances in biomaterials research from our laboratory in the areas of scaffold development, drug delivery and gene therapy, especially as related to applications in bone and cartilage tissue engineering. PMID:22821772

Contributions from research on irradiated ferritic/martensitic steels to materials science and engineering

NASA Astrophysics Data System (ADS)

Gelles, D. S.

1990-05-01

Ferritic and martensitic steels are finding increased application for structural components in several reactor systems. Low-alloy steels have long been used for pressure vessels in light water fission reactors. Martensitic stainless steels are finding increasing usage in liquid metal fast breeder reactors and are being considered for fusion reactor applications when such systems become commercially viable. Recent efforts have evaluated the applicability of oxide dispersion-strengthened ferritic steels. Experiments on the effect of irradiation on these steels provide several examples where contributions are being made to materials science and engineering. Examples are given demonstrating improvements in basic understanding, small specimen test procedure development, and alloy development.

Fuel Aging in Storage and Transportation (FAST): Accelerated Characterization and Performance Assessment of the Used Nuclear Fuel Storage System

DOE Office of Scientific and Technical Information (OSTI.GOV)

McDeavitt, Sean

2016-08-02

This Integrated Research Project (IRP) was established to characterize key limiting phenomena related to the performance of used nuclear fuel (UNF) storage systems. This was an applied engineering project with a specific application in view (i.e., UNF dry storage). The completed tasks made use of a mixture of basic science and engineering methods. The overall objective was to create, or enable the creation of, predictive tools in the form of observation methods, phenomenological models, and databases that will enable the design, installation, and licensing of dry UNF storage systems that will be capable of containing UNF for extended period ofmore » time.« less

A practical teaching course in directed protein evolution using the green fluorescent protein as a model.

PubMed

Ruller, Roberto; Silva-Rocha, Rafael; Silva, Artur; Cruz Schneider, Maria Paula; Ward, Richard John

2011-01-01

Protein engineering is a powerful tool, which correlates protein structure with specific functions, both in applied biotechnology and in basic research. Here, we present a practical teaching course for engineering the green fluorescent protein (GFP) from Aequorea victoria by a random mutagenesis strategy using error-prone polymerase chain reaction. Screening of bacterial colonies transformed with random mutant libraries identified GFP variants with increased fluorescence yields. Mapping the three-dimensional structure of these mutants demonstrated how alterations in structural features such as the environment around the fluorophore and properties of the protein surface can influence functional properties such as the intensity of fluorescence and protein solubility. Copyright © 2011 Wiley Periodicals, Inc.

Translational research-the need of a new bioethics approach.

PubMed

Hostiuc, Sorin; Moldoveanu, Alin; Dascălu, Maria-Iuliana; Unnthorsson, Runar; Jóhannesson, Ómar I; Marcus, Ioan

2016-01-15

Translational research tries to apply findings from basic science to enhance human health and well-being. Many phases of the translational research may include non-medical tasks (information technology, engineering, nanotechnology, biochemistry, animal research, economy, sociology, psychology, politics, and so on). Using common bioethics principles to these areas might sometimes be not feasible, or even impossible. However, the whole process must respect some fundamental, moral principles. The purpose of this paper is to argument the need for a different approach to the morality in translational bioethics, and to suggest some directions that might be followed when constructing such a bioethics. We will show that a new approach is needed and present a few ethical issues that are specific to the translational research.

Research Reports: 1986 NASA/ASEE Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Freeman, L. Michael (Editor); Speer, Fridtjof A. (Editor); Cothran, Ernestine K. (Editor); Karr, Gerald R. (Editor)

1986-01-01

For the 22th consecutive year, a NASA/ASEE Summer Faculty Fellowship Program was conducted for the summer of 1986 by the University of Alabama and Marshall Space Flight Center. The basic objectives of the program are: (1)to further the professional knowledge of qualified engineering and science faculty members; (2)to stimulate an exchange of ideas between participants and NASA; (3)to enrich and refresh the research and teaching activities of the participants' institution; and (4)to contribute to the research objectives of the NASA center. The Faculty Fellows spent ten weeks at MSFC engaged in a research project compatible with their interest and background and worked in collaboration with a NASA/MSFC colleague. This is a compilation of Fellows' reports on their research.

The Improvement of the Learning Process of Basic Disciplines at the Engineering Design.

ERIC Educational Resources Information Center

de Oliveira, Vanderli Fava; Borges, Marcos Martins; Naveiro, Ricardo Manfredi

The goal of this paper is to reflect upon Engineering Education, starting from experiments that have been carried out at the Federal University of Juiz de Fora (UFJF), aiming to improve the learning process of the content of basic drawing disciplines concerned with graphic representation, which are subjects of the initial terms of the courses of…

Parameterizing the Supernova Engine and Its Effect on Remnants and Basic Yields

NASA Astrophysics Data System (ADS)

Fryer, Chris L.; Andrews, Sydney; Even, Wesley; Heger, Alex; Safi-Harb, Samar

2018-03-01

Core-collapse supernova science is now entering an era in which engine models are beginning to make both qualitative and, in some cases, quantitative predictions. Although the evidence in support of the convective engine for core-collapse supernova continues to grow, it is difficult to place quantitative constraints on this engine. Some studies have made specific predictions for the remnant distribution from the convective engine, but the results differ between different groups. Here we use a broad parameterization for the supernova engine to understand the differences between distinct studies. With this broader set of models, we place error bars on the remnant mass and basic yields from the uncertainties in the explosive engine. We find that, even with only three progenitors and a narrow range of explosion energies, we can produce a wide range of remnant masses and nucleosynthetic yields.

Project-oriented teaching model about specialized courses in the information age

NASA Astrophysics Data System (ADS)

Chen, Xiaodong; Wang, Jinjiang; Tian, Qingguo; Wang, Yi; Cai, Huaiyu

2017-08-01

Specialized courses play a significant role in the usage of basic knowledge in the practical application for engineering college students. The engineering data available has sharply increased since the beginning of the information age in the 20th century, providing much more approaches to study and practice. Therefore, how to guide students to make full use of resources for active engineering practice learning has become one of the key problems for specialized courses. This paper took the digital image processing course for opto-electronic information science and technology major as an example, discussed the teaching model of specialized course in the information age, put forward the "engineering resource oriented model", and fostered the ability of engineering students to use the basic knowledge to innovate and deal with specific project objectives. The fusion of engineering examples into practical training and teaching encourages students to practice independent engineering thinking.

Overview of rocket engine control

NASA Technical Reports Server (NTRS)

Lorenzo, Carl F.; Musgrave, Jeffrey L.

1991-01-01

The issues of Chemical Rocket Engine Control are broadly covered. The basic feedback information and control variables used in expendable and reusable rocket engines, such as Space Shuttle Main Engine, are discussed. The deficiencies of current approaches are considered and a brief introduction to Intelligent Control Systems for rocket engines (and vehicles) is presented.

Teacher-to-Teacher: An Annotated Bibliography on DNA and Genetic Engineering.

ERIC Educational Resources Information Center

Mertens, Thomas R., Comp.

1984-01-01

Presented is an annotated bibliography of 24 books on DNA and genetic engineering. Areas considered in these books include: basic biological concepts to help understand advances in genetic engineering; applications of genetic engineering; social, legal, and moral issues of genetic engineering; and historical aspects leading to advances in…

Human research ethics committees in technical universities.

PubMed

Koepsell, David; Brinkman, Willem-Paul; Pont, Sylvia

2014-07-01

Human research ethics has developed in both theory and practice mostly from experiences in medical research. Human participants, however, are used in a much broader range of research than ethics committees oversee, including both basic and applied research at technical universities. Although mandated in the United States, the United Kingdom, Canada, and Australia, non-medical research involving humans need not receive ethics review in much of Europe, Asia, Latin America, and Africa. Our survey of the top 50 technical universities in the world shows that, where not specifically mandated by law, most technical universities do not employ ethics committees to review human studies. As the domains of basic and applied sciences expand, ethics committees are increasingly needed to guide and oversee all such research regardless of legal requirements. We offer as examples, from our experience as an ethics committee in a major European technical university, ways in which such a committee provides needed services and can help ensure more ethical studies involving humans outside the standard medical context. We provide some arguments for creating such committees, and in our supplemental article, we provide specific examples of cases and concerns that may confront technical, engineering, and design research, as well as outline the general framework we have used in creating our committee. © The Author(s) 2014.

The 1993 NASA/ASEE Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Karr, Gerald R. (Editor); Chappell, Charles R. (Editor); Six, Frank (Editor); Freeman, L. Michael (Editor)

1993-01-01

For the 29th consecutive year, a NASA/ASEE Summer Faculty Fellowship Program was conducted at the Marshall Space Flight Center (MSFC). The program was conducted by the University of Alabama in Huntsville and MSFC during the period of 6-1-93 through 8-6-93. Operated under the auspices of the American Society for Engineering Education, the MSFC program, as well as those at other NASA centers, was sponsored by the Office of Educational Affairs, NASA Headquarters, Washington, DC. The basic objectives of the programs, which are in the 30th year of operation nationally, are (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of the participants' institution; and (4) to contribute to the research objectives of the NASA centers.

Research opportunities with compact accelerator-driven neutron sources

NASA Astrophysics Data System (ADS)

Anderson, I. S.; Andreani, C.; Carpenter, J. M.; Festa, G.; Gorini, G.; Loong, C.-K.; Senesi, R.

2016-10-01

Since the discovery of the neutron in 1932 neutron beams have been used in a very broad range of applications, As an aging fleet of nuclear reactor sources is retired the use of compact accelerator-driven neutron sources (CANS) is becoming more prevalent. CANS are playing a significant and expanding role in research and development in science and engineering, as well as in education and training. In the realm of multidisciplinary applications, CANS offer opportunities over a wide range of technical utilization, from interrogation of civil structures to medical therapy to cultural heritage study. This paper aims to provide the first comprehensive overview of the history, current status of operation, and ongoing development of CANS worldwide. The basic physics and engineering regarding neutron production by accelerators, target-moderator systems, and beam line instrumentation are introduced, followed by an extensive discussion of various evolving applications currently exploited at CANS.

Fundamentals of tribology at the atomic level

NASA Technical Reports Server (NTRS)

Ferrante, John; Pepper, Stephen V.

1989-01-01

Tribology, the science and engineering of solid surfaces in moving contact, is a field that encompasses many disciplines: solid state physics, chemistry, materials science, and mechanical engineering. In spite of the practical importance and maturity of the field, the fundamental understanding of basic phenomena has only recently been attacked. An attempt to define some of these problems and indicate some profitable directions for future research is presented. There are three broad classifications: (1) fluid properties (compression, rheology, additives and particulates); (2) material properties of the solids (deformation, defect formation and energy loss mechanisms); and (3) interfacial properties (adhesion, friction chemical reactions, and boundary films). Research in the categories has traditionally been approached by considering macroscopic material properties. Recent activity has shown that some issues can be approached at the atomic level: the atoms in the materials can be manipulated both experimentally and theoretically, and can produce results related to macroscopic phenomena.

A review of gradient stiffness hydrogels used in tissue engineering and regenerative medicine.

PubMed

Xia, Tingting; Liu, Wanqian; Yang, Li

2017-06-01

Substrate stiffness is known to impact characteristics including cell differentiation, proliferation, migration and apoptosis. Hydrogels are polymeric materials distinguished by high water content and diverse physical properties. Gradient stiffness hydrogels are designed by the need to develop biologically friendly materials as extracellular matrix (ECM) alternatives to replace the separated and narrow-ranged hydrogel substrates. Important new discoveries in cell behaviors have been realized with model gradient stiffness hydrogel systems from the two-dimensional (2D) to three-dimensional (3D) scale. Basic and clinical applications for gradient stiffness hydrogels in tissue engineering and regenerative medicine continue to drive the development of stiffness and structure varied hydrogels. Given the importance of gradient stiffness hydrogels in basic research and biomedical applications, there is a clear need for systems for gradient stiffness hydrogel design strategies and their applications. This review will highlight past work in the field of gradient stiffness hydrogels fabrication methods, mechanical property test, applications as well as areas for future study. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1799-1812, 2017. © 2017 Wiley Periodicals, Inc.

Development of a Course of Training Programs for Young Engineers at Work to Nurture the “Basic Competencies of Employees”

NASA Astrophysics Data System (ADS)

Itoh, Michiko; Jomura, Makoto; Hongo, Tetsuyuki; Chohji, Tetsuji

According to our feasibility study in 2005, many of small and medium-sized companies in and around Toyama city asked their young engineers for originality and strong will to try and solve problems positively in their workplaces. These skills have a lot in common with “Basic Competencies of Employees” advocated by the Ministry of Economy, Trade and Industry, Japan. Since Toyama National College of Technology has an accumulated educational know-how to nurture “Basic Competencies of Employees” , we have applied this to develop a course of training programs for young engineers. Through four year‧s practice and improvement, we have established and evaluated this training course. We show the details of our course in this report.

Some historical trends in the research and development of aircraft

NASA Technical Reports Server (NTRS)

Spearman, M. L.

1983-01-01

A survey of some trends in aircraft design was made in an effort to determine the relation between research, development, test, and evaluation (RDT and E) and aircraft mission capability, requirements, and objectives. Driving forces in the history of aircraft include the quest for speed which involved design concepts incorporating jet propulsion systems and low drag features. The study of high speed design concepts promoted new experimental and analytical research techniques. These research techniques, in turn, have lead to concepts offering new performance potential. Design trends were directed toward increased speed, efficiency, productivity, and safety. Generally speaking, the research and development effort has been evolutionary in nature and, with the exception of the transition to supersonic flight, little has occurred since the origin of flight that has drastically changed the basic design fundamentals of aircraft. However, this does not preclude the possibility of dramatic changes in the future since the products of research are frequently unpredictable. Advances should be expected and sought in improved aerodynamics (reduced drag, enhanced lift, flow field exploitation); propulsion (improved engine cycles, multimode engines, alternate fuels, alternate power sources); structures (new materials, manufacturing techniques); all with a view toward increased efficiency and utility.

Small gas turbine combustor experimental study - Compliant metal/ceramic liner and performance evaluation

NASA Technical Reports Server (NTRS)

Acosta, W. A.; Norgren, C. T.

1986-01-01

Combustor research relating to the development of fuel efficient small gas turbine engines capable of meeting future commercial and military aviation needs is currently underway at NASA Lewis. As part of this combustor research, a basic reverse-flow combustor has been used to investigate advanced liner wall cooling techniques. Liner temperature, performance, and exhaust emissions of the experimental combustor utilizing compliant metal/ceramic liners were determined and compared with three previously reported combustors that featured: (1)splash film-cooled liner walls; (2) transpiration cooled liner walls; and (3) counter-flow film cooled panels.

Small gas turbine combustor experimental study: Compliant metal/ceramic liner and performance evaluation

NASA Technical Reports Server (NTRS)

Acosta, W. A.; Norgren, C. T.

1986-01-01

Combustor research relating to the development of fuel efficient small gas turbine engines capable of meeting future commercial and military aviation needs is currently underway at NASA Lewis. As part of this combustor research, a basic reverse-flow combustor has been used to investigate advanced liner wall cooling techniques. Liner temperature, performance, and exhaust emissions of the experimental combustor utilizing compliant metal/ceramic liners were determined and compared with three previously reported combustors that featured: (1) splash film-cooled liner walls; (2) transpiration cooled liner walls; and (3) counter-flow film cooled panels.

Towards the XML schema measurement based on mapping between XML and OO domain

NASA Astrophysics Data System (ADS)

Rakić, Gordana; Budimac, Zoran; Heričko, Marjan; Pušnik, Maja

2017-07-01

Measuring quality of IT solutions is a priority in software engineering. Although numerous metrics for measuring object-oriented code already exist, measuring quality of UML models or XML Schemas is still developing. One of the research questions in the overall research leaded by ideas described in this paper is whether we can apply already defined object-oriented design metrics on XML schemas based on predefined mappings. In this paper, basic ideas for mentioned mapping are presented. This mapping is prerequisite for setting the future approach to XML schema quality measuring with object-oriented metrics.

Alternative Bio-Derived JP-8 Class Fuel and JP-8 Fuel: Flame Tube Combustor Test Results Compared using a GE TAPS Injector Configuration

NASA Technical Reports Server (NTRS)

Hicks, Yolanda R.; Anderson, Robert; Tedder, Sarah

2016-01-01

This paper presents results from tests in a NASA Glenn Research Center (GRC) flame tube facility, where a bio-derived alternate fuel was compared with JP-8 for emissions and general combustion performance. A research version of General Electric Aviation (GE) TAPS injector was used for the tests. Results include 2D, planar laser-based imaging as well as basic flow visualization of the flame. Four conditions were selected that simulate various engine power conditions relevant to NASA Fundamental Aeronautics Supersonics and Environmentally Responsible Aviation Projects were tested.

An overview of expert systems. [artificial intelligence

NASA Technical Reports Server (NTRS)

Gevarter, W. B.

1982-01-01

An expert system is defined and its basic structure is discussed. The knowledge base, the inference engine, and uses of expert systems are discussed. Architecture is considered, including choice of solution direction, reasoning in the presence of uncertainty, searching small and large search spaces, handling large search spaces by transforming them and by developing alternative or additional spaces, and dealing with time. Existing expert systems are reviewed. Tools for building such systems, construction, and knowledge acquisition and learning are discussed. Centers of research and funding sources are listed. The state-of-the-art, current problems, required research, and future trends are summarized.

[Medical application of nano-materials].

PubMed

Jiang, Hui-qing; Chen, Yi-fei

2002-11-01

To review the research progress and medical application of nano-materials. The literature review and comprehensive analysis, methods were used in this study. The Nanotechnology is a typical crossing knowledge. It could be extensively applied in the fields of novel biomaterials, effective transmission of bioactive factor; the detection of functions for all vital organ systems, vascular circulation condition, the control of repair of burn trauma wounds will be monitored by the varied methods of nano technology combined with molecular biological engineering. The application of Nanotechnology will play important roles in clinical medicine, wound repair and basic research for the traditional Chinese medicine.

NASA-UVA light aerospace alloy and structures technology program (LA2ST)

NASA Technical Reports Server (NTRS)

Gangloff, Richard P.; Scully, John R.; Starke, Edgar A., Jr.; Stoner, Glenn E.; Thornton, Earl A.; Wawner, Franklin E., Jr.; Wert, John A.

1994-01-01

The NASA-UVA Light Aerospace Alloy and Structures Technology (LA2ST) Program was initiated in 1986, and continues a high level of activity, with projects being conducted by graduate students and faculty advisors in the Departments of Materials Science and Engineering, and Mechanical and Aerospace Engineering at the University of Virginia. This work is funded by the NASA-Langley Research Center under Grant NAG-1-745. Here, we report on progress achieved between July 1 and December 31, 1993. The objective of the LA2ST Program is to conduct interdisciplinary graduate student research on the performance of next generation, light weight aerospace alloys, composites and thermal gradient structures in collaboration with NASA-Langley researchers. Specific technical objectives are presented for each research project. We generally aim to produce relevant data and basic understanding of material mechanical response, environmental/corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; new solid and fluid mechanics analyses; measurement and modeling advances; and critically, a pool of educated graduate students for aerospace technologies.

NASA-UVA light aerospace alloy and structures technology program (LA2ST)

NASA Astrophysics Data System (ADS)

Gangloff, Richard P.; Scully, John R.; Starke, Edgar A., Jr.; Stoner, Glenn E.; Thornton, Earl A.; Wawner, Franklin E., Jr.; Wert, John A.

1994-03-01

The NASA-UVA Light Aerospace Alloy and Structures Technology (LA2ST) Program was initiated in 1986, and continues a high level of activity, with projects being conducted by graduate students and faculty advisors in the Departments of Materials Science and Engineering, and Mechanical and Aerospace Engineering at the University of Virginia. This work is funded by the NASA-Langley Research Center under Grant NAG-1-745. Here, we report on progress achieved between July 1 and December 31, 1993. The objective of the LA2ST Program is to conduct interdisciplinary graduate student research on the performance of next generation, light weight aerospace alloys, composites and thermal gradient structures in collaboration with NASA-Langley researchers. Specific technical objectives are presented for each research project. We generally aim to produce relevant data and basic understanding of material mechanical response, environmental/corrosion behavior, and microstructure; new monolithic and composite alloys; advanced processing methods; new solid and fluid mechanics analyses; measurement and modeling advances; and critically, a pool of educated graduate students for aerospace technologies.

Turbojet-engine Starting and Acceleration

NASA Technical Reports Server (NTRS)

Mc Cafferty, R. J.; Straight, D. M.

1956-01-01

From considerations of safety and reliability in performance of gas-turbine aircraft, it is clear that engine starting and acceleration are of utmost importance. For this reason extensive efforts have been devoted to the investigation of the factors involved in the starting and acceleration of engines. In chapter III it is shown that certain basic combustion requirements must be met before ignition can occur; consequently, the design and operation of an engine must be tailored to provide these basic requirements in the combustion zone of the engine, particularly in the vicinity of the ignition source. It is pointed out in chapter III that ignition by electrical discharges is aided by high pressure, high temperature, low gas velocity and turbulence, gaseous fuel-air mixture, proper mixture strength, and-an optimum spark. duration. The simultaneous achievement of all these requirements in an actual turbojet-engine combustor is obviously impossible, yet any attempt to satisfy as many requirements as possible will result in lower ignition energies, lower-weight ignition systems, and greater reliability. These factors together with size and cost considerations determine the acceptability of the final ignition system. It is further shown in chapter III that the problem of wall quenching affects engine starting. For example, the dimensions of the volume to be burned must be larger than the quenching distance at the lowest pressure and the most adverse fuel-air ratio encountered. This fact affects the design of cross-fire tubes between adjacent combustion chambers in a tubular-combustor turbojet engine. Only two chambers in these engines contain spark plugs; therefore, the flame must propagate through small connecting tubes between the chambers. The quenching studies indicate that if the cross-fire tubes are too narrow the flame will not propagate from one chamber to another. In order to better understand the role of the basic factors in actual engine operation, many investigations have been conducted in single combustors from gas-turbine engines and in full-scale engines in altitude tanks and in flight. The purpose of the present chapter is to discuss the results of such studies and, where possible, to interpret these results qualitatively in terms of the basic requirements reported in chapter III. The discussion parallels the three phases of turbojet engine starting: (1) Ignition of the fuel-air mixture (2) Propagation of flame throughout the combustion zone (3) Acceleration of the engine to operating speed.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Looney, J.H.; Im, C.J.

The following report presents the technical progress achieved during the first quarter. The completion of this contract entails engineering evaluation in conjunction with basic laboratory research to determine overall process improvements, associated cost savings and the effect of these savings on product price as they relate to the UCC Physical Beneficiation Process for coal-water slurry manufacture. The technical effort for this quarter has concentrated on two basic areas of concern as they relate to the above-mentioned process. First, an engineering evaluation was carried out to examine the critical areas of improvement in the existing UCC Research Corporation single-stage cleaning circuitmore » (coarse coal, heavy media washer). When the plant runs for low ash coal product, at the specific gravity near 1.30, it was found that substantial product contamination resulted from magnetite carry over in the clean coal product. The reduction of the magnetite contamination would entail the application of more spray water to the clean coal drain and rinse screen, and the refinement of the existing dilute media handling system, to accept the increased quality of rinse water. It was also determined that a basic mechanical overhaul is needed on the washbox to ensure dependable operation during the future production of low-ash coal. The various cost elements involved with this renovation were determined by UCC personnel in the operational division. The second area of investigation was concerned with the laboratory evaluation of three separate source coals obtained from United Coal Company (UCC) and nearby mines to determine probable cleanability when using each seam of coal as a feed in the existing beneficiation process. Washability analyses were performed on each sample utilizing a specific gravity range from 1.25 to 1.50. 4 figures, 3 tables.« less

Hydrology for everyone: Share your knowledge

NASA Astrophysics Data System (ADS)

Dogulu, Nilay; Dogulu, Canay

2015-04-01

Hydrology, the science of water, plays a central role in understanding the function and behaviour of water on the earth. Given the increasingly complex, uncertain, and dynamic nature of this system, the study of hydrology presents challenges in solving water-related problems in societies. While researchers in hydrologic science and engineering embrace these challenges, it is important that we also realize our critical role in promoting the basic understanding of hydrology concepts among the general public. Hydrology is everywhere, yet, the general public often lacks the basic understanding of the hydrologic environment surrounding them. Essentially, we believe that a basic level of knowledge on hydrology is a must for everyone and that this knowledge might facilitate resilience of communities to hydrological extremes. For instance, in case of flood and drought conditions, which are the most frequent and widespread hydrological phenomena that societies live with, a key aspect of facilitating community resilience would be to create awareness on the hydrological, meteorological, and climatological processes behind floods and droughts, and also on their potential implications on water resources management. Such knowledge awareness can lead to an increase in individuals' awareness on their role in water-related problems which in turn can potentially motivate them to adopt preparedness behaviours. For these reasons, embracing an approach that will increase hydrologic literacy of the general public should be a common objective for the hydrologic community. This talk, hopefully, will motivate researchers in hydrologic science and engineering to share their knowledge with the general public. We, as early career hydrologists, should take this responsibility more than anybody else. Start teaching hydrology now and share your knowledge with people around you - friends, family, relatives, neighbours, and others. There is hydrology for everyone!

Environmental Management Science Program Workshop. Proceedings

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1998-07-01

The Department of Energy Office of Environmental Management (EM), in partnership with the Office of Energy Research (ER), designed, developed, and implemented the Environmental Management Science Program as a basic research effort to fund the scientific and engineering understanding required to solve the most challenging technical problems facing the government's largest, most complex environmental cleanup program. The intent of the Environmental Management Science Program is to: (1) Provide scientific knowledge that will revolutionize technologies and cleanup approaches to significantly reduce future costs, schedules, and risks. (2) Bridge the gap between broad fundamental research that has wide-ranging applications such as thatmore » performed in the Department's Office of Energy Research and needs-driven applied technology development that is conducted in Environmental Management's Office of Science and Technology. (3) Focus the nation's science infrastructure on critical Department of Energy environmental problems. In an effort to share information regarding basic research efforts being funded by the Environmental Management Science Program and the Environmental Management/Energy Research Pilot Collaborative Research Program (Wolf-Broido Program), this CD includes summaries for each project. These project summaries, available in portable document format (PDF), were prepared in the spring of 1998 by the principal investigators and provide information about their most recent project activities and accomplishments.« less

Effectiveness of E-Learning for Students Vocational High School Building Engineering Program

NASA Astrophysics Data System (ADS)

Soeparno; Muslim, Supari

2018-04-01

Implementation of vocational learning in accordance with the 2013 curriculum must meet the criteria, one of which is learning to be consistent with advances in technology and information. Technology-based learning in vocational commonly referred to as E-Learning, online (in the network) and WBL (Web-Based Learning). Facts on the ground indicate that based learning technology and information on Vocational High School of Building Engineering is still not going well. The purpose of this research is to know: advantages and disadvantages of learning with E-Learning, conformity of learning with E-Learning with characteristics of students on Vocational High School of Building Engineering and effective learning method based on E-Learning for students on Vocational High School of Building Engineering. Research done by literature method, get the following conclusion as follow: the advantages of E-Learning is learning can be done anywhere and anytime, efficient in accessing materials and tasks, ease of communication and discussion; while the shortage is the need for additional costs for good internet access and lack of social interaction between teachers and students. E-learning is appropriate to basic knowledge competencies, and not appropriate at the level of advanced competencies and skills. Effective E-Learning Based Learning Method on Vocational High School of Building Engineering is a Blended method that is a mix between conventional method and e-learning.

To what extent can theory account for the findings of road safety evaluation studies?

PubMed

Elvik, Rune

2004-09-01

This paper proposes a conceptual framework that can be used to assess to what extent the findings of road safety evaluation research make sense from a theoretical point of view. The effects of road safety measures are modelled as passing through two causal chains. One of these, termed the engineering effect, refers to the intended effects of a road safety measure on a set of risk factors related to accident occurrence or injury severity. The engineering effect of road safety measures is modelled in terms of nine basic risk factors, one or more of which any road safety measure needs to influence in order to have the intended effect on accidents or injuries. The other causal chain producing the effects of road safety measures is termed the behavioural effect, and refers to road user behavioural adaptations to road safety measures. The behavioural effect is related to the engineering effect, in the sense that certain properties of the engineering effect of a road safety measure influence the likelihood that behavioural adaptation will occur. The behavioural effect of a road safety measure is modelled in terms of six factors that influence the likelihood that behavioural adaptation will occur. The nine basic risk factors representing the engineering effect of a road safety measure, and the six factors influencing the likelihood of behavioural adaptation can be used as checklists in assessing whether or not the findings of road safety evaluation studies make sense from a theoretical point of view. At the current state of knowledge, a more stringent evaluation of the extent to which theory can explain the findings of road safety evaluation studies is, in most cases, not possible. Copyright 2003 Elsevier Ltd.

Management of Water Quality Data Within the Corps of Engineers, 1979.

DTIC Science & Technology

1980-12-01

integrated data base systems have been in the business area. SIR was developed for scientific researchers. 3. An evaluation of the system is as follows. a...of the UPGRADE system. 3. An evaluation of the system is as follows. a. Advanatges : (1) Anyone who understands the data and principles of anal- ysis...A BASIC UNDERSTANDING OF THE STRUCTURE OF THE UPGRADE SYSTEM START SINRTCOMPUTER ECET IE.ECUTE UPGRADE IA IDN IFY ERINAL TYPE SELECTION OF OPERATIONAL

Science and Technology; Message from the President of the United States Urging Action on his Proposal to Create a New Office of Science and Technology Policy and Approval of his 1977 Budget Requests for Science, Engineering and Technology; Ninety-Fourth Congress, Second Session.

ERIC Educational Resources Information Center

Ford, Gerald R.

This message from President Gerald R. Ford to the 94th Congress briefly explains the major points of his proposal and discusses the areas that would receive special consideration in the 1977 budget: energy, defense, basic research, agriculture, space, and health. (MLH)

Tribology of selected ceramics at temperatures to 900 C

NASA Technical Reports Server (NTRS)

Sliney, H. E.; Jacobson, T. P.; Deadmore, D.; Miyoshi, K.

1986-01-01

Results of fundamental and focused research on the tribological properties of ceramics are discussed. The basic friction and wear characteristics are given for ceramics of interest for use in gas turbine, adiabatic diesel, and Stirling engine applications. The importance of metal oxides in ceramic/metal sliding combinations is illustrated. The formulation and tribological additives are described. Friction and wear data are given for carbide and oxide-based composite coatings for temperatures to at least 900 C.

Basic Visual Disciplines in Heritage Conservation: Outline of Selected Perspectives in Teaching and Learning

NASA Astrophysics Data System (ADS)

Lobovikov-Katz, A.

2017-08-01

Acknowledgement of the value of a basic freehand sketch by the information and communication community of researchers and developers brought about the advanced developments for the use of sketches as free input to complicated processes of computerized visualization, so as to make them more widely accessible. However, a sharp reduction and even exclusion of this and other basic visual disciplines from education in sciences, technology, engineering and architecture dramatically reduces the number of future users of such applications. The unique needs of conservation of cultural heritage pose specific challenges as well as encourage the formulation of innovative development tasks in related areas of information and communication technologies (ICT). This paper claims that the introduction of basic visual disciplines to both communities is essential to the effectiveness of integration of heritage conservation needs and the advanced ICT development of conservation value, and beyond. It provides an insight into the challenges and advantages of introducing these subjects in a relevant educational context, presents some examples of their teaching and learning in the modern environment, including e-learning, and sketches perspectives to their application.

Job Prospects for Industrial Engineers.

ERIC Educational Resources Information Center

Basta, Nicholas

1988-01-01

Discusses 1987 statistics from the College Placement Council regarding new job offers to graduating industrial engineers. Identifies trends in hiring in the field. Describes several issues that will face industrial engineers. States that the industrial engineers most likely to win jobs are those with good basic mathematics and communications…

MO-DE-BRA-04: The CREATE Medical Physics Research Training Network: Training of New Generation Innovators

DOE Office of Scientific and Technical Information (OSTI.GOV)

Seuntjens, J; Collins, L; Devic, S

Purpose: Over the past century, physicists have played a major role in transforming scientific discovery into everyday clinical applications. However, with the increasingly stringent requirements to regulate medical physics as a health profession, the role of physicists as scientists and innovators has become at serious risk of erosion. These challenges trigger the need for a new, revolutionized training program at the graduate level that respects scientific rigor, attention for medical physics-relevant developments in basic sciences, innovation and entrepreneurship. Methods: A grant proposal was funded by the Collaborative REsearch and Training Experience program (CREATE) of the Natural Sciences and Engineering Researchmore » Council (NSERC) of Canada. This enabled the creation of the Medical Physics Research Training Network (MPRTN) around two CAMPEP-accredited medical physics programs. Members of the network consist of medical device companies, government (research and regulatory) and academia. The MPRTN/CREATE program proposes a curriculum with three main themes: (1) radiation physics, (2) imaging & image processing and (3) radiation response, outcomes and modeling. Results: The MPRTN was created mid 2013 (mprtn.com) and features (1) four new basic Ph.D. courses; (2) industry participation in research projects; (3) formal job-readiness training with involvement of guest faculty from academia, government and industry. MPRTN activities since 2013 include 22 conferences; 7 workshops and 4 exchange travels. Three patents were filed or issued, nine awards/best papers were won. Fifteen journal publications were accepted/published, 102 conference abstracts. There are now 13 industry partners. Conclusion: A medical physics research training network has been set up with the goal to harness graduate student’s job-readiness for industry, government and academia in addition to the conventional clinical role. Two years after inception, significant successes have been booked, but the true challenge will be to demonstrate that with this training philosophy CREATE scholars gain access to a much broader job market. Supported by the Natural Sciences and Engineering Research Council (NSERC) Canada.« less

Recent Progress in Genome Editing Approaches for Inherited Cardiovascular Diseases.

PubMed

Kaur, Balpreet; Perea-Gil, Isaac; Karakikes, Ioannis

2018-06-02

This review describes the recent progress in nuclease-based therapeutic applications for inherited heart diseases in vitro, highlights the development of the most recent genome editing technologies and discusses the associated challenges for clinical translation. Inherited cardiovascular disorders are passed from generation to generation. Over the past decade, considerable progress has been made in understanding the genetic basis of inherited heart diseases. The timely emergence of genome editing technologies using engineered programmable nucleases has revolutionized the basic research of inherited cardiovascular diseases and holds great promise for the development of targeted therapies. The genome editing toolbox is rapidly expanding, and new tools have been recently added that significantly expand the capabilities of engineered nucleases. Newer classes of versatile engineered nucleases, such as the "base editors," have been recently developed, offering the potential for efficient and precise therapeutic manipulation of the human genome.

Special issue on the "Consortium for Advanced Simulation of Light Water Reactors Research and Development Progress"

NASA Astrophysics Data System (ADS)

Turinsky, Paul J.; Martin, William R.

2017-04-01

In this special issue of the Journal of Computational Physics, the research and development completed at the time of manuscript submission by the Consortium for Advanced Simulation of Light Water Reactors (CASL) is presented. CASL is the first of several Energy Innovation Hubs that have been created by the Department of Energy. The Hubs are modeled after the strong scientific management characteristics of the Manhattan Project and AT&T Bell Laboratories, and function as integrated research centers that combine basic and applied research with engineering to accelerate scientific discovery that addresses critical energy issues. Lifetime of a Hub is expected to be five or ten years depending upon performance, with CASL being granted a ten year lifetime.

CSBB: synthetic biology research at Newcastle University.

PubMed

Goñi-Moreno, Angel; Wipat, Anil; Krasnogor, Natalio

2017-06-15

The Centre for Synthetic Biology and the Bioeconomy (CSBB) brings together a far-reaching multidisciplinary community across all Newcastle University's faculties - Medical Sciences, Science, Agriculture and Engineering, and Humanities, Arts and Social Sciences. The CSBB focuses on many different areas of Synthetic Biology, including bioprocessing, computational design and in vivo computation, as well as improving understanding of basic molecular machinery. Such breadth is supported by major national and international research funding, a range of industrial partners in the North East of England and beyond, as well as a large number of doctoral and post-doctoral researchers. The CSBB trains the next generation of scientists through a 1-year MSc in Synthetic Biology. © 2017 The Author(s).

Regenerative endodontics as a tissue engineering approach: past, current and future.

PubMed

Malhotra, Neeraj; Mala, Kundabala

2012-12-01

With the reported startling statistics of high incidence of tooth decay and tooth loss, the current interest is focused on the development of alternate dental tissue replacement therapies. This has led to the application of dental tissue engineering as a clinically relevant method for the regeneration of dental tissues and generation of bioengineered whole tooth. Although, tissue engineering approach requires the three main key elements of stem cells, scaffold and morphogens, a conductive environment (fourth element) is equally important for successful engineering of any tissue and/or organ. The applications of this science has evolved continuously in dentistry, beginning from the application of Ca(OH)(2) in vital pulp therapy to the development of a fully functional bioengineered tooth (mice). Thus, with advances in basic research, recent reports and studies have shown successful application of tissue engineering in the field of dentistry. However, certain practical obstacles are yet to be overcome before dental tissue regeneration can be applied as evidence-based approach in clinics. The article highlights on the past achievements, current developments and future prospects of tissue engineering and regenerative therapy in the field of endodontics and bioengineered teeth (bioteeth). © 2012 The Authors. Australian Endodontic Journal © 2012 Australian Society of Endodontology.

Genetically engineered pigs as models for human disease

PubMed Central

Perleberg, Carolin; Kind, Alexander

2018-01-01

ABSTRACT Genetically modified animals are vital for gaining a proper understanding of disease mechanisms. Mice have long been the mainstay of basic research into a wide variety of diseases but are not always the most suitable means of translating basic knowledge into clinical application. The shortcomings of rodent preclinical studies are widely recognised, and regulatory agencies around the world now require preclinical trial data from nonrodent species. Pigs are well suited to biomedical research, sharing many similarities with humans, including body size, anatomical features, physiology and pathophysiology, and they already play an important role in translational studies. This role is set to increase as advanced genetic techniques simplify the generation of pigs with precisely tailored modifications designed to replicate lesions responsible for human disease. This article provides an overview of the most promising and clinically relevant genetically modified porcine models of human disease for translational biomedical research, including cardiovascular diseases, cancers, diabetes mellitus, Alzheimer's disease, cystic fibrosis and Duchenne muscular dystrophy. We briefly summarise the technologies involved and consider the future impact of recent technical advances. PMID:29419487

Engine monitoring display study

NASA Technical Reports Server (NTRS)

Hornsby, Mary E.

1992-01-01

The current study is part of a larger NASA effort to develop displays for an engine-monitoring system to enable the crew to monitor engine parameter trends more effectively. The objective was to evaluate the operational utility of adding three types of information to the basic Boeing Engine Indicating and Crew Alerting System (EICAS) display formats: alphanumeric alerting messages for engine parameters whose values exceed caution or warning limits; alphanumeric messages to monitor engine parameters that deviate from expected values; and a graphic depiction of the range of expected values for current conditions. Ten training and line pilots each flew 15 simulated flight scenarios with five variants of the basic EICAS format; these variants included different combinations of the added information. The pilots detected engine problems more quickly when engine alerting messages were included in the display; adding a graphic depiction of the range of expected values did not affect detection speed. The pilots rated both types of alphanumeric messages (alert and monitor parameter) as more useful and easier to interpret than the graphic depiction. Integrating engine parameter messages into the EICAS alerting system appears to be both useful and preferred.

Building an experience factory for maintenance

NASA Technical Reports Server (NTRS)

Valett, Jon D.; Condon, Steven E.; Briand, Lionel; Kim, Yong-Mi; Basili, Victor R.

1994-01-01

This paper reports the preliminary results of a study of the software maintenance process in the Flight Dynamics Division (FDD) of the National Aeronautics and Space Administration/Goddard Space Flight Center (NASA/GSFC). This study is being conducted by the Software Engineering Laboratory (SEL), a research organization sponsored by the Software Engineering Branch of the FDD, which investigates the effectiveness of software engineering technologies when applied to the development of applications software. This software maintenance study began in October 1993 and is being conducted using the Quality Improvement Paradigm (QIP), a process improvement strategy based on three iterative steps: understanding, assessing, and packaging. The preliminary results represent the outcome of the understanding phase, during which SEL researchers characterized the maintenance environment, product, and process. Findings indicate that a combination of quantitative and qualitative analysis is effective for studying the software maintenance process, that additional measures should be collected for maintenance (as opposed to new development), and that characteristics such as effort, error rate, and productivity are best considered on a 'release' basis rather than on a project basis. The research thus far has documented some basic differences between new development and software maintenance. It lays the foundation for further application of the QIP to investigate means of improving the maintenance process and product in the FDD.

Stem cells in drug discovery, tissue engineering, and regenerative medicine: emerging opportunities and challenges.

PubMed

Nirmalanandhan, Victor Sanjit; Sittampalam, G Sitta

2009-08-01

Stem cells, irrespective of their origin, have emerged as valuable reagents or tools in human health in the past 2 decades. Initially, a research tool to study fundamental aspects of developmental biology is now the central focus of generating transgenic animals, drug discovery, and regenerative medicine to address degenerative diseases of multiple organ systems. This is because stem cells are pluripotent or multipotent cells that can recapitulate developmental paths to repair damaged tissues. However, it is becoming clear that stem cell therapy alone may not be adequate to reverse tissue and organ damage in degenerative diseases. Existing small-molecule drugs and biologicals may be needed as "molecular adjuvants" or enhancers of stem cells administered in therapy or adult stem cells in the diseased tissues. Hence, a combination of stem cell-based, high-throughput screening and 3D tissue engineering approaches is necessary to advance the next wave of tools in preclinical drug discovery. In this review, the authors have attempted to provide a basic account of various stem cells types, as well as their biology and signaling, in the context of research in regenerative medicine. An attempt is made to link stem cells as reagents, pharmacology, and tissue engineering as converging fields of research for the next decade.

B-29 Superfortress with Ramjet Missile

NASA Image and Video Library

1948-08-21

The NACA’s Lewis Flight Propulsion Laboratory used a Boeing B‒29 Superfortress as a testbed for ramjet investigations in the late 1940s. Lewis researchers conducted a wide variety of studies on ramjets to determine basic the operational data necessary to design missiles. Extensive wind tunnel and test stand studies were augmented by actual flight tests. Lewis engineers modified this B‒29 so that the ramjet could be stored in the bomb bay. Once the aircraft reached the desired altitude and speed, a mechanical arm suspended the ramjet 52 inches below the bomb bay. The ramjet’s angle-of-attack could be independently adjusted, and a periscope permitted a view of the test article from inside the aircraft. Researchers took measurements in free-stream conditions at speeds up to Mach 0.51 and at altitudes ranging from 5,000 to 30,000 feet. They then shut the ramjet down and retracted it into the aircraft. The researchers first determined that 14,000 feet was the maximum altitude at which the engine could be ignited by spark. They used flares to start the engine at altitudes up to 30,000 feet. They were able to determine maximum combustion efficiencies, response time to changes in fuel flow, and minimum fuel-air ratios. Overall the ramjet operated well at all speeds and altitudes.

UC Berkeley Nuclear Engineering Curriculum and Research Enhancement. Final report, February 14, 1993--February 14, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fowler, T.K.; Peterson, P.F.

1995-05-11

This is a report for the 2/14/93 to 2/14/95 period of the five-year program proposed and initiated in 1992, for curriculum and research enhancement for the Department of Nuclear Engineering at the University of California, Berkeley. The program is designed to strengthen the departmental academic infrastructure and improve the education breadth of nuclear engineering students. The DOE funds have supported scholarships and a novel educational program which includes summer coursework at the Diablo Canyon Nuclear Power Plant. The summer course provides an important introduction to reactor safety and operations to students who will in the future be responsible for runningmore » many of our existing nuclear power plants. The work was funded under DOE contract DE-FG0393ER75856, with a matching gift to the Department from the Pacific Gas and Electric Company (PG&E). The program described in the original grant proposal has been successful implemented with an enthusiastic response from our students and faculty. The program consisted of two parts, one for innovative additions to our curriculum funded by the DOE, and the other for distinguished lectureships and support for basic research funded by gifts from PG&E.« less

Training for Engineering Craftsmen: The Module System.

ERIC Educational Resources Information Center

Engineering Industry Training Board, London (England).

New arrangements for craft training in the British engineering industry call for a three stage structure: (1) a year of basic training in a wide variety of skills (welding, vehicle painting, electrical engineering, mechanical engineering, and others); (2) selected training in specialized skills under controlled conditions; (3) experience in using…

40 CFR 1042.840 - Application requirements for remanufactured engines.

Code of Federal Regulations, 2013 CFR

2013-07-01

... other basic parameters of the engine's design and emission controls. List the fuel type on which your engines are designed to operate (for example, ultra low-sulfur diesel fuel). List each distinguishable... and the range of values for maximum engine power resulting from production tolerances, as described in...

40 CFR 1042.840 - Application requirements for remanufactured engines.

Code of Federal Regulations, 2012 CFR

2012-07-01

... other basic parameters of the engine's design and emission controls. List the fuel type on which your engines are designed to operate (for example, ultra low-sulfur diesel fuel). List each distinguishable... and the range of values for maximum engine power resulting from production tolerances, as described in...

Custom Search Engines: Tools & Tips

ERIC Educational Resources Information Center

Notess, Greg R.

2008-01-01

Few have the resources to build a Google or Yahoo! from scratch. Yet anyone can build a search engine based on a subset of the large search engines' databases. Use Google Custom Search Engine or Yahoo! Search Builder or any of the other similar programs to create a vertical search engine targeting sites of interest to users. The basic steps to…

Engine Development Design Margins Briefing Charts

NASA Technical Reports Server (NTRS)

Bentz, Chuck

2006-01-01

New engines experience durability problems after entering service. The most prevalent and costly is the hot section, particularly the high-pressure turbine. The origin of durability problems can be traced back to: 1) the basic aero-mechanical design systems, assumptions, and design margins used by the engine designers, 2) the available materials systems, and 3) to a large extent, aggressive marketing in a highly competitive environment that pushes engine components beyond the demonstrated capability of the basic technology available for the hardware designs. Unfortunately the user must operate the engine in the service environment in order to learn the actual thrust loading and the time at max effort take-off conditions used in service are needed to determine the hot section life. Several hundred thousand hours of operational service will be required before the demonstrated reliability of a fleet of engines or the design deficiencies of the engine hot section parts can be determined. Also, it may take three to four engine shop visits for heavy maintenance on the gas path hardware to establish cost effective build standards. Spare parts drive the oerator's engine maintenance costs but spare parts also makes lots of money for the engine manufacturer during the service life of an engine. Unless competition prevails for follow-on engine buys, there is really no motivation for an OEM to spend internal money to improve parts durability and reduce earnings derived from a lucrative spare parts business. If the hot section life is below design goals or promised values, the OEM migh argue that the engine is being operated beyond its basic design intent. On the other hand, the airframer and the operator will continue to remind the OEM that his engine was selected based on a lot of promises to deliver spec thrust with little impact on engine service life if higher thrust is used intermittently. In the end, a standoff prevails and nothing gets fixed. This briefing will propose ways to hold competing engine manufacturers more accountable for engine hot section design margins during the entire Engine Development process as well as provide tools to assess the design temperature margins in the hot section parts of Service Engines.

Research reports: 1994 NASA/ASEE Summer Faculty Fellowship Program

NASA Technical Reports Server (NTRS)

Freeman, L. Michael (Editor); Chappell, Charles R. (Editor); Six, Frank (Editor); Karr, Gerald R. (Editor)

1994-01-01

For the 30th consecutive year, a NASA/ASEE Summer Faculty Fellowship Program was conducted at the Marshall Space Flight Center (MSFC). The basic objectives of the programs, which are in the 31st year of operation nationally, are (1) to further the professional knowledge of qualified engineering and science faculty members; (2) to stimulate an exchange of ideas between participants and NASA; (3) to enrich and refresh the research and teaching activities of participants' institutions; and (4) to contribute to the research objectives of the NASA centers. The Faculty Fellows spent 10 weeks at MSFC engaged in a research project compatible with their interests and background and worked in collaboration with a NASA/MSFC colleague. This document is a compilation of Fellows' reports on their research during the summer of 1994.

Dynamic Control of Aerodynamic Instabilities in Gas Turbine Engines

NASA Technical Reports Server (NTRS)

Greitzer, E. M.; Epstein, A. H.; Guenette, G. R.; Gysling, D. L.; Haynes, J.; Hendricks, G. J.; Paduano, J.; Simon, J. S.; Valavani, L.

1992-01-01

This lecture discusses the use of closed loop control at the component level to enhance the performance of gas turbine engines. The general theme is the suppression of flow instabilities (rotating stall and surge) through use of feedback, either actively or by means of the aeromechanical coupling provided by tailored structures. The basic concepts that underlie active control of turbomachinery instability, and their experimental demonstration, are first described for a centrifugal compressor. It is shown that the mechanism for stabilization is associated with damping of unsteady perturbations in the compression system, and the steady-state performance can thus remain virtually unaltered. Control of instability using a tailored structure is then discussed, along with experimental results illustrating the flow range extension achievable using this technique. A considerably more complex problem is presented by active control or rotating stall where the multi-dimensional features mean that distributed sensing and actuation are required. In addition, there are basic questions concerning unsteady fluid mechanics; these imply the need to resolve issues connected with identification of suitable signals as well as with definition of appropriate wave launchers for implementing the feedback. These issues are discussed and the results of initial successful demonstrations of active control of rotating stall in a single-stage and a three-stage axial compressor are presented. The lecture concludes with suggestions for future research on dynamic control of gas turbine engines.

Effect of Operating Conditions and Design on Afterburner Performance

NASA Technical Reports Server (NTRS)

Fleming, W. A.; Gabriel, D. S.; Lundin, B. T.

1956-01-01

Afterburners for turbojet engines have, within the past decade, found increasing application in service aircraft. Practically all engines manufactured today are equipped with some form of afterburner, and its use has increased from what was originally a short-period thrust-augmentation application to an essential feature of the turbojet propulsion system for flight at supersonic speeds. The design of these afterburners has been based on extensive research and development effort in expanded laboratory facilities by both the NACA and the American engine industry. Most of the work of the engine industry, however, has either not been published or is not generally available owing to its proprietary nature. Consequently, the main bulk of research information available for summary and discussion is of NACA origin. However, because industrial afterburner development has closely followed NACA research, the omission is more one of technical detail than method or concept. One principal difficulty encountered in summarizing the work in this field is that sufficient knowledge does not yet exist to rationally or directly integrate the available background of basic combustion principles into combustor design. A further difficulty is that most of the experimental investigations that have been conducted were directed chiefly toward the development of specific afterburners for various engines rather than to the accumulation of systematic data. This work has, nonetheless, provided not only substantial improvements in the performance of afterburners but also a large fund of experimental data and an extensive background of experience in the field. Consequently, it is the purpose of the present chapter to summarize the many, and frequently unrelated, experimental investigations that have been conducted rather than to formulate a set of design rules. In the treatment of this material an effort has been made, however, to convey to the reader the "know how" acquired by research engineers in the course of afterburner studies.

3D Acoustic Full Waveform Inversion for Engineering Purpose

NASA Astrophysics Data System (ADS)

Lim, Y.; Shin, S.; Kim, D.; Kim, S.; Chung, W.

2017-12-01

Seismic waveform inversion is the most researched data processing technique. In recent years, with an increase in marine development projects, seismic surveys are commonly conducted for engineering purposes; however, researches for application of waveform inversion are insufficient. The waveform inversion updates the subsurface physical property by minimizing the difference between modeled and observed data. Furthermore, it can be used to generate an accurate subsurface image; however, this technique consumes substantial computational resources. Its most compute-intensive step is the calculation of the gradient and hessian values. This aspect gains higher significance in 3D as compared to 2D. This paper introduces a new method for calculating gradient and hessian values, in an effort to reduce computational overburden. In the conventional waveform inversion, the calculation area covers all sources and receivers. In seismic surveys for engineering purposes, the number of receivers is limited. Therefore, it is inefficient to construct the hessian and gradient for the entire region (Figure 1). In order to tackle this problem, we calculate the gradient and the hessian for a single shot within the range of the relevant source and receiver. This is followed by summing up of these positions for the entire shot (Figure 2). In this paper, we demonstrate that reducing the area of calculation of the hessian and gradient for one shot reduces the overall amount of computation and therefore, the computation time. Furthermore, it is proved that the waveform inversion can be suitably applied for engineering purposes. In future research, we propose to ascertain an effective calculation range. This research was supported by the Basic Research Project(17-3314) of the Korea Institute of Geoscience and Mineral Resources(KIGAM) funded by the Ministry of Science, ICT and Future Planning of Korea.

40 projects in stem cell research, tissue engineering, tolerance induction and more (NRP46 "Implants and Transplants" 1999-2006).

PubMed

Thiel, Gilbert T

2007-03-02

Forty projects on stem cell research, tissue and matrix engineering, tolerance induction and other topics were supported by the Swiss National Research Program NRP46 (Implants, Transplants) from 1999-2006. The last project is devoted to developing stem cell lines from frozen surplus human embryos in Switzerland, which would otherwise have to be destroyed at the end of 2008. It is entitled JESP (Joint Embryonic Stem Cell Project) since it involves two Swiss universities, in vitro fertilisation centres and experts from the humanities (ethics and law) to handle this difficult problem. Over the years, stem cell transplantation and tissue/matrix engineering have drawn closer to each other and even developed synergies. Progress in stem cell research has been slower than anticipated, but a multitude of technical skills (phenotyping, isolation, transfection, induction of differentiation, labelling, expanding cells in culture, etc) were acquired. Understanding of stem cell biology has grown. The 7 projects on tissue and matrix engineering progressed closer to clinical applicability than the stem cell projects. Of 3 projects to implant encapsulated cells for the production of hormones (insulin, erythropoietin), one is close to clinical pilot studies with an advanced encapsulated device. Five projects were devoted to mechanisms of tolerance or the role of metzincins in chronic allograft nephropathy. Four studies in psychology and communication in transplantation were funded, as were 5 projects in ethics, law and the history of transplantation in Switzerland. The goal of NRP46 was to provide an impulse for research in these new fields and bring together experts from the humanities, biology and medicine to cope more effectively with the problems of regenerative medicine in the future. The majority of goals were attained, mainly in the basics.

Emerging trends and new developments in regenerative medicine: a scientometric update (2000 - 2014).

PubMed

Chen, Chaomei; Dubin, Rachael; Kim, Meen Chul

2014-09-01

Our previous scientometric review of regenerative medicine provides a snapshot of the fast-growing field up to the end of 2011. The new review identifies emerging trends and new developments appearing in the literature of regenerative medicine based on relevant articles and reviews published between 2000 and the first month of 2014. Multiple datasets of publications relevant to regenerative medicine are constructed through topic search and citation expansion to ensure adequate coverage of the field. Networks of co-cited references representing the literature of regenerative medicine are constructed and visualized based on a combined dataset of 71,393 articles published between 2000 and 2014. Structural and temporal dynamics are identified in terms of most active topical areas and cited references. New developments are identified in terms of newly emerged clusters and research areas. Disciplinary-level patterns are visualized in dual-map overlays. While research in induced pluripotent stem cells remains the most prominent area in the field of regenerative medicine, research related to clinical and therapeutic applications in regenerative medicine has experienced a considerable growth. In addition, clinical and therapeutic developments in regenerative medicine have demonstrated profound connections with the induced pluripotent stem cell research and stem cell research in general. A rapid adaptation of graphene-based nanomaterials in regenerative medicine is evident. Both basic research represented by stem cell research and application-oriented research typically found in tissue engineering are now increasingly integrated in the scientometric landscape of regenerative medicine. Tissue engineering is an interdisciplinary field in its own right. Advances in multiple disciplines such as stem cell research and graphene research have strengthened the connections between tissue engineering and regenerative medicine.

CRISPR/Cas9 Immune System as a Tool for Genome Engineering.

PubMed

Hryhorowicz, Magdalena; Lipiński, Daniel; Zeyland, Joanna; Słomski, Ryszard

2017-06-01

CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated) adaptive immune systems constitute a bacterial defence against invading nucleic acids derived from bacteriophages or plasmids. This prokaryotic system was adapted in molecular biology and became one of the most powerful and versatile platforms for genome engineering. CRISPR/Cas9 is a simple and rapid tool which enables the efficient modification of endogenous genes in various species and cell types. Moreover, a modified version of the CRISPR/Cas9 system with transcriptional repressors or activators allows robust transcription repression or activation of target genes. The simplicity of CRISPR/Cas9 has resulted in the widespread use of this technology in many fields, including basic research, biotechnology and biomedicine.

Using synthetic biology to interface with physical micro and nano-sized sensors (Conference Presentation)

NASA Astrophysics Data System (ADS)

Hanson, Russell; Fuller, Jason; Cheng, Andrew

2017-05-01

This talk will discuss the current goals and efforts of point of care and personal health monitoring systems: what they can do now and what is in the works. These interfaces can be used in a precision medicine context—making diagnoses and getting the right drugs to the right patients at the right time. Many of the same sensors and engineering are being prototyped now for neural interfaces and recording devices with applications in visual, auditory, and motor cortex, allowing basic research along with preliminary applications in actuation and sensing. While miniaturization and electronics development using established manufacturing protocols can provide the current engineering foundations, novel biochemical ligands and molecular detectors can provide the needed flexibility for next-generation devices.

Hack the Planet: What we Talk About When we Talk About Geoengineering

NASA Astrophysics Data System (ADS)

Kintisch, E.

2010-12-01

Hack the Planet (Wiley, 2010) explores how an idea once basically anathema to meetings like AGU has, in the space of a few years, become part of the geoscience mainstream. Through chapters involving researchers like David Battisti, Stephen Salter, Edward Teller and Brent Constanz the book documents the roots of this shift and how scientists are breaking new ground in the controversial field. And it shows how trying to engineer the planet's climate or manage its carbon poses novel scientific, geopolitical and moral risks and rewards. This session will cover how the topic of climate engineering has moved from something geoscientists don't talk about to something geoscientists can talk about, to something, in my view, that geoscientists must talk about.

Comparison of Engine/Inlet Distortion Measurements with MEMS and ESP Pressure Sensors

NASA Technical Reports Server (NTRS)

Soto, Hector L.; Hernandez, Corey D.

2004-01-01

A study of active-flow control in a small-scale boundary layer ingestion inlet was conducted at the NASA Langley Basic Aerodynamic Research Tunnel (BART). Forty MEMS pressure sensors, in a rake style configuration, were used to examine both the mean (DC) and high frequency (AC) components of the total pressure across the inlet/engine interface plane. The mean component was acquired and used to calculate pressure distortion. The AC component was acquired separately, at a high sampling rate, and is used to study the unsteady effects of the active-flow control. An identical total pressure rake, utilizing an Electronically Scanned Pressure (ESP) system, was also used to calculate distortion; a comparison of the results obtained using the two rakes is presented.

Plasma Physics at the National Science Foundation

NASA Astrophysics Data System (ADS)

Lukin, Vyacheslav

2017-10-01

The Town Meeting on Plasma Physics at the National Science Foundation will provide an opportunity for Q&A about the variety of NSF programs and solicitations relevant to a broad cross-section of the academic plasma science community, from graduating college seniors to senior leaders in the field, and from plasma astrophysics to basic physics to plasma engineering communities. We will discuss recent NSF-hosted events, research awards, and multi-agency partnerships aimed at enabling the progress of science in plasma science and engineering. Future outlook for plasma physics and broader plasma science support at NSF, with an emphasis on how you can help NSF to help the community, will be speculated upon within the uncertainty of the federal budgeting process.

Preparation of low viscosity epoxy acrylic acid photopolymer prepolymer in light curing system

NASA Astrophysics Data System (ADS)

Li, P.; Huang, J. Y.; Liu, G. Z.

2018-01-01

With the integration and development of materials engineering, applied mechanics, automatic control and bionics, light cured composite has become one of the most favourite research topics in the field of materials and engineering at home and abroad. In the UV curing system, the prepolymer and the reactive diluent form the backbone of the cured material together. And they account for more than 90% of the total mass. The basic properties of the cured product are mainly determined by the prepolymer. A low viscosity epoxy acrylate photosensitive prepolymer with a viscosity of 6800 mPa • s (25 °C ) was obtained by esterification of 5 hours with bisphenol A epoxy resin with high epoxy value and low viscosity.

Neurophysiology and neural engineering: a review.

PubMed

Prochazka, Arthur

2017-08-01

Neurophysiology is the branch of physiology concerned with understanding the function of neural systems. Neural engineering (also known as neuroengineering) is a discipline within biomedical engineering that uses engineering techniques to understand, repair, replace, enhance, or otherwise exploit the properties and functions of neural systems. In most cases neural engineering involves the development of an interface between electronic devices and living neural tissue. This review describes the origins of neural engineering, the explosive development of methods and devices commencing in the late 1950s, and the present-day devices that have resulted. The barriers to interfacing electronic devices with living neural tissues are many and varied, and consequently there have been numerous stops and starts along the way. Representative examples are discussed. None of this could have happened without a basic understanding of the relevant neurophysiology. I also consider examples of how neural engineering is repaying the debt to basic neurophysiology with new knowledge and insight. Copyright © 2017 the American Physiological Society.

Responsible innovation: a pilot study with the U.K. Engineering and Physical Sciences Research Council.

PubMed

Owen, Richard; Goldberg, Nicola

2010-11-01

Significant time lags between the development of novel innovations (e.g., nanotechnologies), understanding of their wider impacts, and subsequent governance (e.g., regulation) have led to repeated calls for more anticipatory and adaptive approaches that promote the responsible emergence of new technologies in democratic societies. A key challenge is implementation in a pragmatic way. Results are presented of a study with the Engineering and Physical Sciences Research Council, the largest public funder of basic innovation research in the United Kingdom who, for the first time, asked applicants to submit a risk register identifying the wider potential impacts and associated risks (environment, health, societal, and ethical) of their proposed research. This focused on nanoscience for carbon capture and utilization. Risk registers were completed conservatively, with most identified impacts concerning researchers' health associated with nanoparticle synthesis, handling, and prototype device fabrication, i.e., risks that could be identified and managed with a reasonable level of certainty. Few wider environmental impacts and no future impacts on society were identified, reflecting the often uncertain and unpredictable nature of innovation. However, some applicants addressed this by including investigators with expertise beyond engineering and nanosciences supporting integrated activities that included life cycle and real-time technology assessment, which in some cases were also framed by stakeholder and/or public engagement. Proposals underpinned by a strong commitment to responsible science and innovation promoted continuous reflexivity, embedding a suite of multidisciplinary approaches around the innovation research core to support decisions modulating the trajectory of their innovation research in real-time.

Construction and Analysis of Electronic circuits

NASA Technical Reports Server (NTRS)

Thomas, Ashley N.

2004-01-01

The Aviation Environmental Technical Branch produces many various types of aeronautical research that benefits the NASA mission for space exploration and in turn, produces new technology for our nation. One of the present goals of the Aviation Environmental Technical Branch is to create better engines for airplanes by testing supersonic jet propulsion and safe fuel combustion. During the summer of 2004, I was hired by Vincent Sattenvhite Chief executive of the Aviation Environmental Technical Branch to Assist Yves Lamothe with a fuel igniter circuit. Yves Lamothe is an electrical engineer who is currently working on safe fuel combustion testing. This testing is planned to determine the minimum ignition energy for fuel and air vapors of current and alternative fuels under simulated flight conditions. An air temperature bath will provide simulated flight profile temperatures and the heat fluxes to the test chamber. I was assigned with Yves to help complete the igniter circuit which consists of a 36k voltage supply an oscilloscope, and a high voltage transistor switch. During my tenure in the L.E.C.I.R.P. program I studied the basics of electricity and circuitry along with two other projects that I completed. In the beginning of my internship, I devote all of my time to research the aspects of circuitry so that I would be prepared for the projects that I was assigned to do. I read about lessons on; the basic physical concepts of electronics, Electrical units, Basic dc circuits, direct current circuit analysis, resistance and cell batteries, various types of magnetism , Alternating current basics, inductance, and power supplies. I received work sheets and math equations from my Mentor so that I could be able to apply these concepts into my work. After I complete my studies, I went on to construct a LED chaser circuit which displays a series of light patterns using a 555 timer. I incorporated a switch and motion detector into the circuit to create basic alarm system. This project challenged my ability to interpret a schematic and expand it. While I was still completing the LED chaser circuit I Also was given A Basic Stamp Toddler Robot to build and program. The Toddler robot can walk in 36 various styles using advanced robotics. I used many different programs to create movement and direction of the robot. Also the Toddler can use infrared vision to sense objects. This enables the robot to maneuver indefinitely without running into objects. During my tenure at the NASA Glen Research Center I definite utilized the NASA mission to educate. I learned valuable information to help in my up coming year as a freshman in college.

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

The Ames Laboratory conducts fundamental research in the physical, chemical, materials, and mathematical sciences and engineering which underlie energy generating, conversion, transmission and storage technologies, environmental improvement, and other technical areas essential to national needs. These efforts will be maintained so as to contribute to the achievement of the vision of DOE and, more specifically, to increase the general levels of knowledge and technical capabilities, to prepare engineering and physical sciences students for the future, both academia and industry, and to develop new technologies and practical applications from our basic scientific programs that will contribute to a strengthening of themore » US economy. The Laboratory approaches all its operations with the safety and health of all workers as a constant objective and with genuine concern for the environment. The Laboratory relies upon its strengths in materials synthesis and processing, materials reliability, chemical analysis, chemical sciences, photosynthesis, materials sciences, metallurgy, high-temperature superconductivity, and applied mathematical sciences to conduct the long term basic and intermediate range applied research needed to solve the complex problems encountered in energy production, and utilization as well as environmental restoration and waste management. Ames Laboratory will continue to maintain a very significant and highly beneficial pre-college math and science education program which currently serves both teachers and students at the middle school and high school levels. Our technology transfer program is aided by joint efforts with ISU`s technology development and commercialization enterprise and will sustain concerted efforts to implement Cooperative Research and Development Agreements, industrially sponsored Work for Others projects. and scientific personnel exchanges with our various customers.« less

Between Industry and Academia: A Physicist's Experiences at The Aerospace Corporation

NASA Astrophysics Data System (ADS)

Camparo, James

2005-03-01

The Aerospace Corporation is a nonprofit company whose purposes are exclusively scientific: to provide research, development, and advisory services for space programs that serve the national interest, primarily the Air Force's Space and Missile Systems Center and the National Reconnaissance Office. The corporation's laboratory has a staff of about 150 scientists who conduct research in fields ranging from Space Sciences to Material Sciences and from Analytical Chemistry to Atomic Physics. As a consequence, Aerospace stands midway between an industrial research laboratory, focused on product development, and academic/national laboratories focused on basic science. Drawing from Dr. Camparo's personal experiences, the presentation will discuss advantages and disadvantages of a career at Aerospace, including the role of publishing in peer-reviewed journals and the impact of work on family life. Additionally, the presentation will consider the balance between basic physics, applied physics, and engineering in the work at Aerospace. Since joining Aerospace in 1981, Dr. Camparo has worked as an atomic physicist specializing in the area of atomic clocks, and has had the opportunity to experiment and publish on a broad range of research topics including: the stochastic-field/atom interaction, radiation effects on semiconductor materials, and stellar scintillation.

VII International Congress of Engineering Physics

NASA Astrophysics Data System (ADS)

2015-01-01

In the frame of the fortieth anniversary celebration of the Universidad Autónoma Metropolitana and the Physics Engineering career, the Division of Basic Science and Engineering and its Departments organized the "VII International Congress of Physics Engineering". The Congress was held from 24 to 28 November 2014 in Mexico City, Mexico. This congress is the first of its type in Latin America, and because of its international character, it gathers experts on physics engineering from Mexico and all over the globe. Since 1999, this event has shown research, articles, projects, technological developments and vanguard scientists. These activities aim to spread, promote, and share the knowledge of Physics Engineering. The topics of the Congress were: • Renewable energies engineering • Materials technology • Nanotechnology • Medical physics • Educational physics engineering • Nuclear engineering • High precision instrumentation • Atmospheric physics • Optical engineering • Physics history • Acoustics This event integrates lectures on top trending topics with pre-congress workshops, which are given by recognized scientists with an outstanding academic record. The lectures and workshops allow the exchange of experiences, and create and strengthen research networks. The Congress also encourages professional mobility among all universities and research centres from all countries. CIIF2014 Organizing and Editorial Committee Dr. Ernesto Rodrigo Vázquez Cerón Universidad Autónoma Metropolitana - Azcapotzalco ervc@correo.azc.uam.mx Dr. Luis Enrique Noreña Franco Universidad Autónoma Metropolitana - Azcapotzalco lnf@correo.azc.uam.mx Dr. Alberto Rubio Ponce Universidad Autónoma Metropolitana - Azcapotzalco arp@correo.azc.uam.mx Dr. Óscar Olvera Neria Universidad Autónoma Metropolitana - Azcapotzalco oon@correo.azc.uam.mx Professor Jaime Granados Samaniego Universidad Autónoma Metropolitana - Azcapotzalco jgs@correo.azc.uam.mx Dr. Roberto Tito Hernández López Universidad Autónoma Metropolitana - Azcapotzalco hlrt@correo.azc.uam.mx Dr. Anatolio Martínez Jiménez Universidad Autónoma Metropolitana - Azcapotzalco amartinez@correo.azc.uam.mx Dr. Eusebio Guzmán Serrano Universidad Autónoma Metropolitana - Azcapotzalco gse@correo.azc.uam.mx

One more thing: Faculty response to increased emphasis on project teams in undergraduate engineering education

NASA Astrophysics Data System (ADS)

Hunter, Jane

Tenured and tenure-track faculty members at institutions of higher education, especially those at Research I institutions, are being asked to do more than ever before. With rapidly changing technology, significant decreases in public funding, the shift toward privately funded research, and the ever increasing expectations of students for an education that adequately prepares them for professional careers, engineering faculty are particularly challenged by the escalating demands on their time. In 1996, the primary accreditation organization for engineering programs (ABET) adopted new criteria that required, among other things, engineering programs to teach students to function on multidisciplinary teams and to communicate effectively. In response, most engineering programs utilize project teams as a strategy for teaching these skills. The purpose of this qualitative study of tenured and tenure track engineering faculty at a Research I institution in the southwestern United States was to explore the variety of ways in which the engineering faculty responded to the demands placed upon them as a result of the increased emphasis on project teams in undergraduate engineering education. Social role theory and organizational climate theory guided the study. Some faculty viewed project teams as an opportunity for students to learn important professional skills and to benefit from collaborative learning but many questioned the importance and feasibility of teaching teamwork skills and had concerns about taking time away from other essential fundamental material such as mathematics, basic sciences and engineering sciences. Although the administration of the College of Engineering articulated strong support for the use of project teams in undergraduate education, the prevailing climate did little to promote significant efforts related to effective utilization of project teams. Too often, faculty were unwilling to commit sufficient time or effort to make project teamwork a truly valuable learning opportunity because those efforts were not perceived to be valuable and were rarely rewarded. Few formal professional development opportunities were available and few incentives were in place to encourage other informal efforts to develop the necessary skills. Those who committed significant effort to project teams were challenged by concerns about team composition, student accountability and assigning individual grades for group teamwork.

Stan Butchart climbing into B-47

NASA Image and Video Library

1954-07-14

From December 10, 1966, until his retirement on February 27, 1976, Stanley P. Butchart served as Chief (later, Director) of Flight Operations at NASA's Flight Research Center (renamed on March 26, 1976, the Hugh L. Dryden Flight Research Center). Initially, his responsibilities in this position included the Research Pilots Branch, a Maintenance and Manufacturing Branch, and an Operations Engineering Branch, the last of which not only included propulsion and electrical/electronic sections but project engineers for the X-15 and lifting bodies. During his tenure, however, the responsibilities of his directorate came to include not only Flight Test Engineering Support but Flight Systems and Loads laboratories. Before becoming Chief of Flight Operations, Butchart had served since June of 1966 as head of the Research Pilots Branch (Chief Pilot) and then as acting chief of Flight Operations. He had joined the Center (then known as the National Advisory Committee for Aeronautics' High-Speed Flight Research Station) as a research pilot on May 10, 1951. During his career as a research pilot, he flew a great variety of research and air-launch aircraft including the D-558-I, D-558-II, B-29 (plus its Navy version, the P2B), X-4, X-5, KC-135, CV-880, CV-990, B-47, B-52, B-747, F-100A, F-101, F-102, F-104, PA-30 Twin Comanche, JetStar, F-111, R4D, B-720, and B-47. Although previously a single-engine pilot, he became the Center's principal multi-engine pilot during a period of air-launches in which the pilot of the air-launch aircraft (B-29 or P2B) basically directed the operations. It was he who called for the chase planes before each drop, directed the positioning of fire rescue vehicles, and released the experimental aircraft after ensuring that all was ready for the drop. As pilot of the B-29 and P2B, Butchart launched the X-1A once, the X-1B 13 times, the X-1E 22 times, and the D-558-II 102 times. In addition, he towed the M2-F1 lightweight lifting body 14 times behind an R4

Automotive Stirling engine development program

NASA Technical Reports Server (NTRS)

Farrell, R.; Hindes, C.; Battista, R.; Connelly, M.; Cronin, M.; Howarth, R.; Donahue, A.; Slate, E.; Stotts, R.; Lacy, R.

1988-01-01

The study of high power kinematic Stirling engines for transportation use, testing of Mod I and Mod II Stirling engines, and component development activities are summarized. Mod II development testing was performed to complete the development of the basic engine and begin characterization of performance. Mod I engines were used for Mod II component development and to obtain independent party (U.S. Air Force) evaluation of Stirling engine vehicle performance.

Lewis Research Center R and D Facilities

NASA Technical Reports Server (NTRS)

1991-01-01

The NASA Lewis Research Center (LeRC) defines and develops advanced technology for high priority national needs. The work of the Center is directed toward new propulsion, power, and communications technologies for application to aeronautics and space, so that U.S. leadership in these areas is ensured. The end product is knowledge, usually in a report, that is made fully available to potential users--the aircraft engine industry, the energy industry, the automotive industry, the space industry, and other NASA centers. In addition to offices and laboratories for almost every kind of physical research in such fields as fluid mechanics, physics, materials, fuels, combustion, thermodynamics, lubrication, heat transfer, and electronics, LeRC has a variety of engineering test cells for experiments with components such as compressors, pumps, conductors, turbines, nozzles, and controls. A number of large facilities can simulate the operating environment for a complete system: altitude chambers for aircraft engines; large supersonic wind tunnels for advanced airframes and propulsion systems; space simulation chambers for electric rockets or spacecraft; and a 420-foot-deep zero-gravity facility for microgravity experiments. Some problems are amenable to detection and solution only in the complete system and at essentially full scale. By combining basic research in pertinent disciplines and generic technologies with applied research on components and complete systems, LeRC has become one of the most productive centers in its field in the world. This brochure describes a number of the facilities that provide LeRC with its exceptional capabilities.

Nanotechnology and bone healing.

PubMed

Harvey, Edward J; Henderson, Janet E; Vengallatore, Srikar T

2010-03-01

Nanotechnology and its attendant techniques have yet to make a significant impact on the science of bone healing. However, the potential benefits are immediately obvious with the result that hundreds of researchers and firms are performing the basic research needed to mature this nascent, yet soon to be fruitful niche. Together with genomics and proteomics, and combined with tissue engineering, this is the new face of orthopaedic technology. The concepts that orthopaedic surgeons recognize are fabrication processes that have resulted in porous implant substrates as bone defect augmentation and medication-carrier devices. However, there are dozens of applications in orthopaedic traumatology and bone healing for nanometer-sized entities, structures, surfaces, and devices with characteristic lengths ranging from 10s of nanometers to a few micrometers. Examples include scaffolds, delivery mechanisms, controlled modification of surface topography and composition, and biomicroelectromechanical systems. We review the basic science, clinical implications, and early applications of the nanotechnology revolution and emphasize the rich possibilities that exist at the crossover region between micro- and nanotechnology for developing new treatments for bone healing.

New trends in articular cartilage repair.

PubMed

Cucchiarini, Magali; Henrionnet, Christel; Mainard, Didier; Pinzano, Astrid; Madry, Henning

2015-12-01

Damage to the articular cartilage is an important, prevalent, and unsolved clinical issue for the orthopaedic surgeon. This review summarizes innovative basic research approaches that may improve the current understanding of cartilage repair processes and lead to novel therapeutic options. In this regard, new aspects of cartilage tissue engineering with a focus on the choice of the best-suited cell source are presented. The importance of non-destructive cartilage imaging is highlighted with the recent availability of adapted experimental tools such as Second Harmonic Generation (SHG) imaging. Novel insights into cartilage pathophysiology based on the involvement of the infrapatellar fat pad in osteoarthritis are also described. Also, recombinant adeno-associated viral vectors are discussed as clinically adapted, efficient tools for potential gene-based medicines in a variety of articular cartilage disorders. Taken as a whole, such advances in basic research in diverse fields of articular cartilage repair may lead to the development of improved therapies in the clinics for an improved, effective treatment of cartilage lesions in a close future.

From the basics to application of cell therapy, a steppingstone to the conquest of neurodegeneration: a meeting report.

PubMed

Park, Dong-Hyuk; Eve, David J; Borlongan, Cesario V; Klasko, Stephen K; Cruz, L Eduardo; Sanberg, Paul R

2009-02-01

The annual meeting of the American Society for Neural Therapy and Repair (ASNTR) showcases the latest research trends in neurodegenerative disease and the related medical regenerative science. The 2008 ASNTR meeting covered a variety of different topics ranging from basic research to exploration of currently unknown pathogenesis and mechanisms for specific neurodegenerative disease such as Parkinson's disease, Alzheimer's disease, or stroke. This included studies to characterize stem cells, such as neural stem cells, embryonic stem cells, bone marrow mesenchymal stem cells, and human umbilical cord blood cells, for transplantation and the conditions necessary to maximize the efficacy of endogenous and exogenous stem cells, such as isolation, purification, differentiation, and migration. Moreover, a number of studies looked at methods for more advanced application of transplantation of cells or specific factors, through tissue engineering or manipulation beyond simple injection. Finally, well-known or previously un-known dietary supplementation or pharmacological materials that can affect the nervous system positively or negatively, were also important topics.

PREFACE: 7th EEIGM International Conference on Advanced Materials Research

NASA Astrophysics Data System (ADS)

Joffe, Roberts

2013-12-01

The 7th EEIGM Conference on Advanced Materials Research (AMR 2013) was held at Luleå University of Technology on the 21-22 March 2013 in Luleå, SWEDEN. This conference is intended as a meeting place for researchers involved in the EEIGM programme, in the 'Erasmus Mundus' Advanced Materials Science and Engineering Master programme (AMASE) and the 'Erasmus Mundus' Doctoral Programme in Materials Science and Engineering (DocMASE). This is great opportunity to present their on-going research in the various fields of Materials Science and Engineering, exchange ideas, strengthen co-operation as well as establish new contacts. More than 60 participants representing six countries attended the meeting, in total 26 oral talks and 19 posters were presented during two days. This issue of IOP Conference Series: Materials Science and Engineering presents a selection of articles from EEIGM-7 conference. Following tradition from previous EEIGM conferences, it represents the interdisciplinary nature of Materials Science and Engineering. The papers presented in this issue deal not only with basic research but also with applied problems of materials science. The presented topics include theoretical and experimental investigations on polymer composite materials (synthetic and bio-based), metallic materials and ceramics, as well as nano-materials of different kind. Special thanks should be directed to the senior staff of Division of Materials Science at LTU who agreed to review submitted papers and thus ensured high scientific level of content of this collection of papers. The following colleagues participated in the review process: Professor Lennart Walström, Professor Roberts Joffe, Professor Janis Varna, Associate Professor Marta-Lena Antti, Dr Esa Vuorinen, Professor Aji Mathew, Professor Alexander Soldatov, Dr Andrejs Purpurs, Dr Yvonne Aitomäki, Dr Robert Pederson. Roberts Joffe October 2013, Luleå Conference photograph EEIGM7 conference participants, 22 March 2013 The PDF contains the book of abstracts.

System safety engineering analysis handbook

NASA Technical Reports Server (NTRS)

Ijams, T. E.

1972-01-01

The basic requirements and guidelines for the preparation of System Safety Engineering Analysis are presented. The philosophy of System Safety and the various analytic methods available to the engineering profession are discussed. A text-book description of each of the methods is included.

Seismic Methods

EPA Pesticide Factsheets

Seismic methods are the most commonly conducted geophysical surveys for engineering investigations. Seismic refraction provides engineers and geologists with the most basic of geologic data via simple procedures with common equipment.

Exploration on the matching between Optical Comprehensive Design Experiment and Washington Accord

NASA Astrophysics Data System (ADS)

Cao, Yiping; Chen, Wenjing; Zhang, Qican; Liu, Yuankun; Li, Dahai; Zhou, Xinzhi; Wei, Jun

2017-08-01

Common problems faced in optical comprehensive design experiment and going against the Washington Accord are pointed out. For resolving these problems, an instructional and innovative teaching scheme for Optics Comprehensive Design Experiment is proposed. We would like to understand the student that can improve the hands-on practical ability, theory knowledge understanding ability, complex problem solving ability, engineering application ability, cooperative ability after tracking and researching the student who have attended the class about Optical Comprehensive Design Experiment, We found that there are some problems on the course such as the experiment content vague, the student beginning less time, phase separation theory and engineering application, the experiment content lack of selectivity and so on. So we have made some improvements reference to the Washington Accord for the class teaching plan about Optical Comprehensive Design Experiment. This class must relevant to the engineering basic courses, professional foundation course and the major courses, so far as to the future study and work that which can play a role in inheriting and continuity to the students. The Optical Comprehensive Design Experiment teaching program requires students learning this course to have learnt basic courses like analog electronics technique, digital electronic technique, applied optics and computer and other related courses which students are required to comprehensively utilize. This teaching scheme contains six practical complex engineering problems which are respectively optical system design, light energy meter design, illuminometer design, material refractive index measuring system design, light intensity measuring system design and open design. Establishing the optional experiment and open experiment can provide students with a greater choice and enhance the students' creativity, vivid teaching experimental teachers and enriching contents of experiment can make the experiment more interesting, providing students with more opportunities to conduct experiment and improving students' practical ability with long learning time, putting emphasis on student's understanding of complex engineering problems and the cognitive of the process to solve complex engineering problems with actual engineering problems. Applying the scheme in other courses and improving accordingly will be able to ensure the quality of engineering education. Look forward to offering useful reference for the curriculum system construction in colleges and universities.

[Genome editing ~Principle and possibility of a novel genetic engineering technology. Basic principles of genome editing.

PubMed

Yamamoto, Takashi

Programmable site-specific nuclease mediated-genome editing is an emerging biotechnology for precise manipulation of target genes. In genome editing, gene-knockout as well as gene-knockin are possible in various organisms and cultured cells. CRISPR-Cas9, which was developed in 2012, is a convenient and efficient programmable site-specific nuclease and the use spreads around the world rapidly. For this, it is important for the progress of life science research to introduce the genome editing technology.

Research in Electronic/Electrical Engineering at British Universities,

DTIC Science & Technology

1981-04-30

and Wales. There are basically two sets of examinations, the Ordinary and Advanced, known as Ŕ and A levels ." O levels are normally taken after 4 or 5...years of secondary school; A levels after 6 or 7 years. Admission to a professional school, such as one that trains nurses, for example, or...determined by the particular university, but 4 subjects is a common number. In addition, a "pass" in several A levels is required. Suppose a young man wishes

NASA/Howard University Large Space Structures Institute

NASA Technical Reports Server (NTRS)

Broome, T. H., Jr.

1984-01-01

Basic research on the engineering behavior of large space structures is presented. Methods of structural analysis, control, and optimization of large flexible systems are examined. Topics of investigation include the Load Correction Method (LCM) modeling technique, stabilization of flexible bodies by feedback control, mathematical refinement of analysis equations, optimization of the design of structural components, deployment dynamics, and the use of microprocessors in attitude and shape control of large space structures. Information on key personnel, budgeting, support plans and conferences is included.

Status and Direction of Tribology as a Science in the 80's. Understanding and Prediction

NASA Technical Reports Server (NTRS)

Tabor, D.

1984-01-01

The most challenging research problems in tribology for the next decade or beyond are classified horizontally into two categories: (1) understanding of basic mechanisms and (2) prediction of practical performance. Vertical classifications are in terms of particular themes or fields of interest. Areas where more fundamental work is required are: adhesion and friction of clean and contaminated surfaces; lubrication; new materials; surface characterization at the engineering level (topography) and at the atomic levels (various spectroscopies); and wear.

Advances in the Systems and Processes for the Production of Gamma Titanium Aluminide Bars and Powder

NASA Astrophysics Data System (ADS)

Haun, Robert E.

2017-12-01

A historical look at the melt processing of gamma titanium aluminides is presented first, followed by recent advances in melting equipment design by Retech to produce 50-mm and 100-mm-diameter ingots up to 1000 mm long. Equipment design for the economical production of gamma titanium aluminide powder is then discussed. The focus in industry has shifted away from basic research to cost-effective production of these titanium alloys for aerospace and automotive engine applications.