42 CFR 65a.6 - How will applications be evaluated?

Code of Federal Regulations, 2014 CFR

2014-10-01

..., INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES HAZARDOUS SUBSTANCES BASIC RESEARCH... that purpose, including review by the National Advisory Environmental Health Sciences Council in... Environmental Health Sciences Council. ...

42 CFR 65a.6 - How will applications be evaluated?

Code of Federal Regulations, 2012 CFR

2012-10-01

..., INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES HAZARDOUS SUBSTANCES BASIC RESEARCH... that purpose, including review by the National Advisory Environmental Health Sciences Council in... Environmental Health Sciences Council. ...

42 CFR 65a.6 - How will applications be evaluated?

Code of Federal Regulations, 2013 CFR

2013-10-01

..., INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES HAZARDOUS SUBSTANCES BASIC RESEARCH... that purpose, including review by the National Advisory Environmental Health Sciences Council in... Environmental Health Sciences Council. ...

42 CFR 65a.6 - How will applications be evaluated?

Code of Federal Regulations, 2010 CFR

2010-10-01

... that purpose, including review by the National Advisory Environmental Health Sciences Council in..., INTERNSHIPS, TRAINING NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES HAZARDOUS SUBSTANCES BASIC RESEARCH... Environmental Health Sciences Council. ...

Theoretical models for application in school health education research.

PubMed

Parcel, G S

1984-01-01

Theoretical models that may be useful to research studies in school health education are reviewed. Selected, well-defined theories include social learning theory, problem-behavior theory, theory of reasoned action, communications theory, coping theory, social competence, and social and family theories. Also reviewed are multiple theory models including models of health related-behavior, the PRECEDE Framework, social-psychological approaches and the Activated Health Education Model. Two major reviews of teaching models are also discussed. The paper concludes with a brief outline of the general applications of theory to the field of school health education including applications to basic research, development and design of interventions, program evaluation, and program utilization.

Research progress in Asia on methods of processing laser-induced breakdown spectroscopy data

NASA Astrophysics Data System (ADS)

Guo, Yang-Min; Guo, Lian-Bo; Li, Jia-Ming; Liu, Hong-Di; Zhu, Zhi-Hao; Li, Xiang-You; Lu, Yong-Feng; Zeng, Xiao-Yan

2016-10-01

Laser-induced breakdown spectroscopy (LIBS) has attracted much attention in terms of both scientific research and industrial application. An important branch of LIBS research in Asia, the development of data processing methods for LIBS, is reviewed. First, the basic principle of LIBS and the characteristics of spectral data are briefly introduced. Next, two aspects of research on and problems with data processing methods are described: i) the basic principles of data preprocessing methods are elaborated in detail on the basis of the characteristics of spectral data; ii) the performance of data analysis methods in qualitative and quantitative analysis of LIBS is described. Finally, a direction for future development of data processing methods for LIBS is also proposed.

Alternative Modes of Evaluation and Their Application to Rural Development.

ERIC Educational Resources Information Center

Wetherill, G. Richard; Buttram, Joan L.

In order to "cut through the jargon of the multifaceted field of evaluative research", 21 evaluation models representing a range of possibilities were identified (via literature review) and compared in terms of purpose and five basic phases applicable to rural development. Evaluation was defined as "the systematic examination of a…

34 CFR 97.118 - Applications and proposals lacking definite plans for involvement of human subjects.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Education PROTECTION OF HUMAN SUBJECTS Federal Policy for the Protection of Human Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.118 Applications and proposals lacking definite plans..., or contracts are submitted to departments or agencies with the knowledge that subjects may be...

On applying cognitive psychology.

PubMed

Baddeley, Alan

2013-11-01

Recent attempts to assess the practical impact of scientific research prompted my own reflections on over 40 years worth of combining basic and applied cognitive psychology. Examples are drawn principally from the study of memory disorders, but also include applications to the assessment of attention, reading, and intelligence. The most striking conclusion concerns the many years it typically takes to go from an initial study, to the final practical outcome. Although the complexity and sheer timescale involved make external evaluation problematic, the combination of practical satisfaction and theoretical stimulation make the attempt to combine basic and applied research very rewarding. © 2013 The British Psychological Society.

[Some worries about Dendrobium officinale industry].

PubMed

Li, Guang; Lu, Juan; Chen, Xi

2013-02-01

In recent years, with the continuous development of the industry of Dendrobium officinale, the technological alliance on CEEUSRO has been established. However, many problems also exposed with the rapid expansion of the industry, such as weak basic research, single species of the product, lack of in-depth studies and difficult to guarantee the quality. Industrial foam was gradually formed. To guard against the D. officinale becoming another "Puer Tea" , the authors believe that the key to sustainable development of the industry is enterprises and research institutes should strengthen basic research, speed up development of application of integrated innovations, government should strengthen guidance, regulate the operation of the market, then protect the quality of D. officinale in the market.

A Student's Guide to Navigating the IRB: How to Successfully Navigate a Potentially Overwhelming Process

ERIC Educational Resources Information Center

Murphy, Corinne M.; Verden, Claire

2011-01-01

Graduate students must complete a research project to receive their degree. In addition to this basic requirement, the student may be required to submit a research proposal and application to the governing Institutional Review Board (IRB) for approval prior to beginning the research project. This article describes the IRB process and offers tips…

Translational genetics: advancing fronts for craniofacial health.

PubMed

D'Souza, R N; Dunnwald, M; Dunnvald, M; Frazier-Bowers, S; Polverini, P J; Wright, J T; de Rouen, T; Vieira, A R

2013-12-01

Scientific opportunities have never been better than today! The completion of the Human Genome project has sparked hope and optimism that cures for debilitating conditions can be achieved and tailored to individuals and communities. The availability of reference genome sequences and genetic variations as well as more precise correlations between genotype and phenotype have facilitated the progress made in finding solutions to clinical problems. While certain craniofacial and oral diseases previously deemed too difficult to tackle have benefited from basic science and technological advances over the past decade, there remains a critical need to translate the fruits of several decades' worth of basic and clinical research into tangible therapies that can benefit patients. The fifth Annual Fall Focused Symposium, "Translational Genetics - Advancing Fronts for Craniofacial Health", was created by the American Association for Dental Research (AADR) to foster its mission to advance interdisciplinary research that is directed toward improving oral health. The symposium showcased progress made in identifying molecular targets that are potential therapeutics for common and rare dental diseases and craniofacial disorders. Speakers focused on translational and clinical applications of their research and, where applicable, on strategies for new technologies and therapeutics. The critical needs to transfer new knowledge to the classroom and for further investment in the field were also emphasized. The symposium underscored the importance of basic research, chairside clinical observations, and population-based studies in driving the new translational connections needed for the development of cures for the most common and devastating diseases involving the craniofacial complex.

Developments in laser Doppler blood perfusion monitoring

NASA Astrophysics Data System (ADS)

Leahy, Martin J.; de Mul, Frits F. M.; Nilsson, Gert E.; Maniewski, Roman; Liebert, Adam

2003-03-01

This paper reviews the development and use of laser Doppler perfusion monitors and imagers. Despite their great success and almost universal applicability in microcirculation research, they have had great difficulty in converting to widespread clinical application. The enormous interest in microvascular blood perfusion coupled with the 'ease of use' of the technique has led to 2000+ publications citing its use. However, useful results can only be achieved with an understanding of the basic principles of the instrumentation and its application in the various clinical disciplines. The basic technical background is explored and definitions of blood perfusion and laser Doppler perfusion are established. The calibration method is then described together with potential routes to standardisation. A guide to the limitations in application of the technique gives the user a clear indication of what can be achieved in new studies as well as possible inadequacy in some published investigations. Finally some clinical applications have found acceptability and these will be explored.

PREFACE: Ferrofluids

NASA Astrophysics Data System (ADS)

Odenbach, Professor Stefan

2006-09-01

This issue of Journal of Physics: Condensed Matter is dedicated to results in the field of ferrofluid research. Ferrofluids—suspensions of magnetic nanoparticles—exhibit as a specific feature the magnetic control of their physical parameters and of flows appearing in such fluids. This magnetic control can be achieved by means of moderate magnetic fields with a strength of the order of 10 mT. This sort of magnetic control also enables the design of a wide variety of technical applications such as the use of the magnetic forces for basic research in fluid dynamics. The overall field of ferrofluid research is already about 40 years old. Starting with the first patent on the synthesis of magnetic nanoparticle suspensions by S Papell in 1964, a vivid field of research activities has been established. Looking at the long time in which ferrofluids have been the focus of scientific interest, one can ask the question, what kind of recent developments justify a special issue of a scientific journal? New developments in a field, which depends strongly on a certain material class and which opens research possibilities in different scientific fields will nowadays usually require an interdisciplinary approach. This kind of approach starting from the synthesis of magnetic suspensions, including research concerning their basic properties and flow behaviour and focusing on new applications has been the core of a special research programme funded by the Deutsche Forschungsgemeinschaft (DFG) over the past 6 years. Within this programme—entitled `Colloidal Magnetic Fluids: Basics, Synthesis and Applications of New Ferrofluids'—more than 30 different research groups have been coordinated to achieve new results in various fields related to ferrofluid research. The basic approach of the program has been the assumption that new applications well beyond the typical ferrofluid techniques, for example loud speaker cooling or sealing of rotary shafts, will require tailored magnetic suspensions with properties clearly focused towards the need of the application. While such tailoring of fluids to certain well defined properties sounds like a straightforward approach one has to face the fact that it requires a clear definition of the required properties. This definition itself has to be based on a fundamental physical knowledge of the processes determining certain magnetically controlled phenomena in ferrofluids. To make this point concrete one can look into the detailed aims of the mentioned research program. The application areas identified for the future development of research and application of suspensions of magnetic nanoparticles have been on the one hand the biomedical application—especially with respect to cancer treatment—and on the other hand the use of magnetically controlled rheological properties of ferrofluids for new active technical devices. Both directions require, as mentioned, as a basis for success the synthesis of new ferrofluids with dedicated properties. While the medical applications have to rely on biocompatibility as well as on stability of the suspensions in a biomedical environment, the use of ferrofluids in technical devices employing their magnetically controlled rheological properties will depend on an enhancement of the changes of the fluid's viscous properties in the presence of moderate magnetic fields. For both requirements ferrofluids with a make up clearly different from the usual magnetite based fluids have to be synthesized. The question of how the detailed microscopic make up of the fluids would have to look has to be answered on the basis of basic research results defining the physics background of the respective phenomena. Taking these aspects together it becomes obvious that the aforementioned research program had goals aiming far beyond the state of the art of classical ferrofluid research. These goals as well as the basic strategy to achieve them is in a way reflected by the structure of this issue of Journal of Physics: Condensed Matter. The issue contains results emerging from the research programme as well as invited papers from researchers not participating in the programme but working in closely related areas. The issue is subdivided into five main sections dealing with synthesis, basic physical description, rheology, and both the medical and technical applications of ferrofluids. As can be expected from work done within an interdisciplinary context many of the papers would fit into more than one of these sections and catagorization is thus sometimes difficult. We have therefore tried to place them into the section reflecting the main field of research to which the respective results belong. The first section is on synthesis and characterization of magnetic suspensions. The first paper in this section is dedicated partly to magnetite ferrofluids but with special aspects concerning the particle size tailoring them for applications especially in the field of magnetic hyperthermia. After this, three different types of `new' ferrofluids are presented. Fluids based on pure metal particles exhibiting much stronger magnetic properties than the common magnetite fluids, fluids with a temperature sensitive surfactant shell allowing a change of the particle’s hydrodynamic diameter by variation of the fluid’s temperature and fluids containing spheres of nonmagnetic material with embedded magnetic particles which are already used in new medical applications. The second section is dedicated to the basic physics of ferrofluids and highlights three different topics. First the question of magnetization dynamics is discussed and different aspects of this fundamental problem, which determines the basic description of ferrofluids, are highlighted. The second topic is the well known surface instability appearing in ferrofluids in a homogeneous magnetic field perpendicular to the fluid surface. This part shows clearly how many undiscovered phenomena can be found, even in an area which is as old as the whole research field, if an appropriate measuring technique is used and fresh ideas help to find unexpected effects. The last part of this section deals with the question of dynamics and structure of ferrofluids and shows the experimental possibilities of scattering techniques in this field. Within the third section the question of field dependent changes of the rheological behaviour of ferrofluids is discussed. The first three papers provide theoretical approaches for the understanding of the connection between the rheological properties and shear and field induced changes in the fluid’s microstructure. The fourth paper provides the related experimental results showing the combination of microstructural and rheological measurements under well defined conditions. The last paper of this section does not directly belong to ferrofluid research but to a closely related field—so called magneto-rheological (MR) suspensions, which differ from ferrofluids mainly by the size of the suspended particles and the strength of the rheological effects. As modern theoretical approaches, like the one discussed by Liu et al in the second section have shown, the relation between the effects in ferrofluids and those in MR fluids is so close that it could probably be described in a common theory. Sections four and five contain the application orientated results. In the fourth section the medical applications are the focus of interest. The section starts with a paper which could have also been placed in the synthesis section—the growth of magnetotactic bacteria and the extraction of the magnetic particles produced by these bacteria. The paper also contains information about the characterization of the particles especially with respect to their application. The characterization aspect is then continued in two papers outlining new diagnostic techniques with close relation to future biomedical application of magnetic fluids. Next in vitro applications, especially questions of cell separation using magnetic forces, are highlighted before the final papers address the therapeutic aspects of magnetic drug targeting and magnetic hyperthermia. Finally the fifth section describes three different new approaches for the technical use of ferrofluids. Again, the specialized design of the fluids themselves is an important step towards the new application goals. Altogether the papers within this issue outline the unique potential of magnetically controlled suspensions, the interdisciplinary nature of the related research and the prospects of strongly networked and interdisciplinary activities in the field. I hope that it will give an insight into the fascination of ferrofluid research and a feeling for the advances made in the past years.

Current advances in research and clinical applications of PLGA-based nanotechnology

PubMed Central

Lü, Jian-Ming; Wang, Xinwen; Marin-Muller, Christian; Wang, Hao; Lin, Peter H; Yao, Qizhi; Chen, Changyi

2009-01-01

Co-polymer poly(lactic-co-glycolic acid) (PLGA) nanotechnology has been developed for many years and has been approved by the US FDA for the use of drug delivery, diagnostics and other applications of clinical and basic science research, including cardiovascular disease, cancer, vaccine and tissue engineering. This article presents the more recent successes of applying PLGA-based nanotechnologies and tools in these medicine-related applications. It focuses on the possible mechanisms, diagnosis and treatment effects of PLGA preparations and devices. This updated information will benefit to both new and established research scientists and clinical physicians who are interested in the development and application of PLGA nanotechnology as new therapeutic and diagnostic strategies for many diseases. PMID:19435455

Metabolomics and Type 2 Diabetes: Translating Basic Research into Clinical Application.

PubMed

Klein, Matthias S; Shearer, Jane

2016-01-01

Type 2 diabetes (T2D) and its comorbidities have reached epidemic proportions, with more than half a billion cases expected by 2030. Metabolomics is a fairly new approach for studying metabolic changes connected to disease development and progression and for finding predictive biomarkers to enable early interventions, which are most effective against T2D and its comorbidities. In metabolomics, the abundance of a comprehensive set of small biomolecules (metabolites) is measured, thus giving insight into disease-related metabolic alterations. This review shall give an overview of basic metabolomics methods and will highlight current metabolomics research successes in the prediction and diagnosis of T2D. We summarized key metabolites changing in response to T2D. Despite large variations in predictive biomarkers, many studies have replicated elevated plasma levels of branched-chain amino acids and their derivatives, aromatic amino acids and α-hydroxybutyrate ahead of T2D manifestation. In contrast, glycine levels and lysophosphatidylcholine C18:2 are depressed in both predictive studies and with overt disease. The use of metabolomics for predicting T2D comorbidities is gaining momentum, as are our approaches for translating basic metabolomics research into clinical applications. As a result, metabolomics has the potential to enable informed decision-making in the realm of personalized medicine.

Metabolomics and Type 2 Diabetes: Translating Basic Research into Clinical Application

PubMed Central

Klein, Matthias S.; Shearer, Jane

2016-01-01

Type 2 diabetes (T2D) and its comorbidities have reached epidemic proportions, with more than half a billion cases expected by 2030. Metabolomics is a fairly new approach for studying metabolic changes connected to disease development and progression and for finding predictive biomarkers to enable early interventions, which are most effective against T2D and its comorbidities. In metabolomics, the abundance of a comprehensive set of small biomolecules (metabolites) is measured, thus giving insight into disease-related metabolic alterations. This review shall give an overview of basic metabolomics methods and will highlight current metabolomics research successes in the prediction and diagnosis of T2D. We summarized key metabolites changing in response to T2D. Despite large variations in predictive biomarkers, many studies have replicated elevated plasma levels of branched-chain amino acids and their derivatives, aromatic amino acids and α-hydroxybutyrate ahead of T2D manifestation. In contrast, glycine levels and lysophosphatidylcholine C18:2 are depressed in both predictive studies and with overt disease. The use of metabolomics for predicting T2D comorbidities is gaining momentum, as are our approaches for translating basic metabolomics research into clinical applications. As a result, metabolomics has the potential to enable informed decision-making in the realm of personalized medicine. PMID:26636104

Apply for a Research Grant

Cancer.gov

The NCI Grants Process provides an overview of the end-to-end lifecycle of grant funding. Learn about the types of funding available and the basics for application, review, award, and on-going administration within the NCI.

77 FR 30327 - Manufacturer of Controlled Substances; Notice Of Application; Research Triangle Institute

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-22

... the following basic classes of controlled substances: Drug Schedule Marihuana (7360) I Cocaine (9041) II The Institute will manufacture marihuana, and cocaine derivatives for use by their customers in...

Mechanisms, applications, and perspectives of antiviral RNA silencing in plants

PubMed Central

Garcia-Ruiz, Hernan; Ruiz, Mayra Teresa Garcia; Peralta, Sergio Manuel Gabriel; Gabriel, Cristina Betzabeth Miravel; El-Mounadi, Kautar

2017-01-01

Viral diseases of plants cause important economic losses due to reduction in crop quality and quantity to the point of threatening food security in some countries. Given the reduced availability of natural sources, genetic resistance to viruses has been successfully engineered for some plant-virus combinations. A sound understanding of the basic mechanisms governing plant-virus interactions, including antiviral RNA silencing, is the foundation to design better management strategies and biotechnological approaches to engineer and implement antiviral resistance in plants. In this review, we present current molecular models to explain antiviral RNA silencing and its application in basic plant research, biotechnology and genetic engineering. PMID:28890589

The Potential of Artificial Intelligence in Aids for the Disabled.

ERIC Educational Resources Information Center

Boyer, John J.

The paper explores the possibilities for applying the knowledge of artificial intelligence (AI) research to aids for the disabled. Following a definition of artificial intelligence, the paper reviews areas of basic AI research, such as computer vision, machine learning, and planning and problem solving. Among application areas relevant to the…

Pain Control Research in the Terminally Ill.

ERIC Educational Resources Information Center

Levy, Michael H.

1988-01-01

Two main goals in the care of the terminally ill are to optimize the quality of their remaining life and to alleviate the distress of their survivors. Pain control research has contributed significantly to meeting those goals, but continued progress is needed in both basic studies and expanded applications of new techniques. (Author/NB)

45 CFR 46.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2010 CFR

2010-10-01

... Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROTECTION OF HUMAN SUBJECTS Basic HHS Policy for Protection of Human Research Subjects § 46.120 Evaluation and disposition of... will take into consideration the risks to the subjects, the adequacy of protection against these risks...

Information Warehouse – A Comprehensive Informatics Platform for Business, Clinical, and Research Applications

PubMed Central

Kamal, Jyoti; Liu, Jianhua; Ostrander, Michael; Santangelo, Jennifer; Dyta, Ravi; Rogers, Patrick; Mekhjian, Hagop S.

2010-01-01

Since its inception in 1997, the IW (Information Warehouse) at the Ohio State University Medical Center (OSUMC) has gradually transformed itself from a single purpose business decision support system to a comprehensive informatics platform supporting basic, clinical, and translational research. The IW today is the combination of four integrated components: a clinical data repository containing over a million patients; a research data repository housing various research specific data; an application development platform for building business and research enabling applications; a business intelligence environment assisting in reporting in all function areas. The IW is structured and encoded using standard terminologies such as SNOMED-CT, ICD, and CPT. The IW is an important component of OSUMC’s Clinical and Translational Science Award (CTSA) informatics program. PMID:21347019

White Paper on Nuclear Data Needs and Capabilities for Basic Science

DOE Office of Scientific and Technical Information (OSTI.GOV)

Batchelder, J.; Kawano, T.; Kelley, J.

Reliable nuclear structure and reaction data represent the fundamental building blocks of nuclear physics and astrophysics research, and are also of importance in many applications. There is a continuous demand for high-quality updates of the main nuclear physics databases via the prompt compilation and evaluation of the latest experimental and theoretical results. The nuclear physics research community benefits greatly from comprehensive, systematic and up-to-date reviews of the experimentally determined nuclear properties and observables, as well as from the ability to rapidly access these data in user-friendly forms. Such credible databases also act as a bridge between science, technology, and societymore » by making the results of basic nuclear physics research available to a broad audience of users, and hence expand the societal utilization of nuclear science. Compilation and evaluation of nuclear data has deep roots in the history of nuclear science research, as outlined in Appendix 1. They have an enormous impact on many areas of science and applications, as illustrated in Figure 2 for the Evaluated Nuclear Structure Data File (ENSDF) database. The present workshop concentrated on the needs of the basic nuclear science community for data and capabilities. The main role of this community is to generate and use data in order to understand the basic nuclear forces and interactions that are responsible for the existence and the properties of all nuclides and, as a consequence, to gain knowledge about the origins, evolution and structure of the universe. Thus, the experiments designed to measure a wealth of nuclear properties towards these fundamental scientific goals are typically performed from within this community.« less

Electronic Data Interchange in U.S. Navy Contracting Activities

DTIC Science & Technology

1992-12-01

the basic research question, the following subsidiary questions were asked: 1. How is EDI being used in the private sector and within the Department of...eliminated by using EDI transactions. According to a DoD small business EDI Guide , (DLA Partnership, 1991, p.15) in financial management applications, a...and to place orders against basic ordering agreements (BOA). The ASO is currently transmitting the ASC X12 850 [Purchase Order] to approximately 25

Analysis of Decision Factors for the Application of Information Access Controls within the Organization

ERIC Educational Resources Information Center

Foerster, Carl A.

2013-01-01

The application of access controls on internal information necessarily impacts the availability of that information for sharing inside the enterprise. The decisions establishing the degree of control are a crucial first step to balance the requirements to protect and share. This research develops a set of basic decision factors and examines other…

Plasma Processing of Materials

DTIC Science & Technology

1985-02-22

inert gas or in a reduced pressure environment) one can obtain rapidly solidified metastable (i.e., amorphous, microcrystalline, and supersaturated...integrated circuits dnd thus is an area of’vital : importance to our electronics industry. Applications utilizing noble gas plasmas, such as ion-plating...phenomena and probably will not benefit -ubstantially from acditional basic research. Applications utilizing molecular gas plasmas, where reactive species

Introduction to polymer-based solid-contact ion-selective electrodes-basic concepts, practical considerations, and current research topics.

PubMed

Bieg, Christoph; Fuchsberger, Kai; Stelzle, Martin

2017-01-01

This review aims at providing an introductory overview for researchers new to the field of ion-selective electrodes. Both state of the art technology and novel developments towards solid-contact reference (sc-RE) and solid-contact ion selective electrodes (sc-ISE) are discussed. This technology has potentially widespread and important applications provided certain performance criteria can be met. We present basic concepts, operation principles, and theoretical considerations with regard to their function. Analytical performance and suitability of sc-RE and sc-ISE for a given application depend on critical parameters, which are discussed in this review. Comprehensive evaluation of sensor performance along this set of parameters is considered indispensable to allow for a well-founded comparison of different technologies. Methods and materials employed in the construction of sc-RE and sc-ISE, in particular the solid contact and the polymer membrane composite, are presented and discussed in detail. Operation principles beyond potentiometry are mentioned, which would further extend the field of ISE application. Finally, we conclude by directing the reader to important areas for further scientific research and development work considered particularly critical and promising for advancing this field in sensor R&D. Graphical Abstract ᅟ.

[Medical application of nano-materials].

PubMed

Jiang, Hui-qing; Chen, Yi-fei

2002-11-01

To review the research progress and medical application of nano-materials. The literature review and comprehensive analysis, methods were used in this study. The Nanotechnology is a typical crossing knowledge. It could be extensively applied in the fields of novel biomaterials, effective transmission of bioactive factor; the detection of functions for all vital organ systems, vascular circulation condition, the control of repair of burn trauma wounds will be monitored by the varied methods of nano technology combined with molecular biological engineering. The application of Nanotechnology will play important roles in clinical medicine, wound repair and basic research for the traditional Chinese medicine.

Commercialization of basic research from within the university and return of value to the public

PubMed Central

Hammerstedt, Roy H; Blach, Edward L

2008-01-01

The responsibility to return “value” to those who support basic research is an obligatory part of accepting funds to support the research. This reality should, but now does not, impact planning and execution of all basic research from its earliest stages. Universities are becoming ever more important in their role in the accelerating quest of a national goal of transition to a “knowledge based economy.” As such, the complex organizational format of a university, laden with entrenched procedures of questionable utility, should be adjusted to identify the means to commercialize the small subset of projects that appear suitable for further development. Of special concern is the growing tendency to encourage academic “innovators” to develop spin-out companies “on the side.” While seductive in perceived simplicity, this is a difficult step and we believe that most such individuals are ill-suited to these activities. Not because of technical ability but because of lack of relevant management experience. We attempt to address that situation through a brief listing of some reasons why people “do research” and outline phases (steps) in moving from concept to application, including an overview of start-up and funding early-stage spin-outs. A discussion of the limits to applying results of basic research to enhancing sperm fertility in commodity and companion animals and humans is provided. Hurdles are so daunting that there is concern as to why anyone would attempt to translate basic observations into practical solutions; which in turn raises the question of why funding agencies should fund basic studies in the first place. PMID:18164880

Applied Multiple Linear Regression: A General Research Strategy

ERIC Educational Resources Information Center

Smith, Brandon B.

1969-01-01

Illustrates some of the basic concepts and procedures for using regression analysis in experimental design, analysis of variance, analysis of covariance, and curvilinear regression. Applications to evaluation of instruction and vocational education programs are illustrated. (GR)

Teaching Reinforcement of Stochastic Behavior Using Monte Carlo Simulation.

ERIC Educational Resources Information Center

Fox, William P.; And Others

1996-01-01

Explains a proposed block of instruction that would give students in industrial engineering, operations research, systems engineering, and applied mathematics the basic understanding required to begin more advanced courses in simulation theory or applications. (DDR)

A critical review of the field application of a mathematical model of malaria eradication

PubMed Central

Nájera, J. A.

1974-01-01

A malaria control field research trial in northern Nigeria was planned with the aid of a computer simulation based on Macdonald's mathematical model of malaria epidemiology. Antimalaria attack was based on a combination of mass drug administration (chloroquine and pyrimethamine) and DDT house spraying. The observed results were at great variance with the predictions of the model. The causes of these discrepancies included inadequate estimation of the model's basic variables, and overestimation, in planning the simulation, of the effects of the attack measures and of the degree of perfection attainable by their application. The discrepancies were to a great extent also due to deficiencies in the model. An analysis is made of those considered to be the most important. It is concluded that research efforts should be encouraged to increase our knowledge of the basic epidemiological factors, their variation and correlations, and to formulate more realistic and useful theoretical models. PMID:4156197

Photonics and terahertz tchnologies: part 1

NASA Astrophysics Data System (ADS)

Romaniuk, Ryszard S.

2011-10-01

This digest paper debates basic features of the terahertz band of frequencies. There are presented fundamental characteristics of the basic terahertz system consisting of a THz source, propagation media, transmission lines, THz signal processing, and detectors. Such a system finds research application, but also practical in two main areas: terahertz imaging - transmissive and reflective, and as a close range THz radar, but also as sensory systems mainly for molecular sensing. There were launched in this country a few THz research projects concerning the THz sources, detectors and their applications. Among these projects there is an infrastructural one called FOTEH, opened at the WUT. The details of this project are debated and the consequences of its realization in this country. The first part of the paper is an introduction debating THz band and comparing it with the photonics one. The second part presents the assumptions of the infrastructural FOTEH project on Photonics and Terahertz Technologies.

Thermodynamics and Diffusion Coupling in Alloys—Application-Driven Science

NASA Astrophysics Data System (ADS)

Ågren, John

2012-10-01

As emphasized by Stokes (1997), the common assumption of a linear progression from basic research (science), via applied research, to technological innovations (engineering) should be questioned. In fact, society would gain much by supporting long-term research that stems from practical problems and has usefulness as a key word. Such research may be fundamental, and often, it cannot be distinguished from "basic" research if it were not for its different motivation. The development of the Calphad method and the more recent development of accompanying kinetic approaches for diffusion serve as excellent examples and are the themes of this symposium. The drivers are, e.g., the development of new materials, processes, and lifetime predictions. Many challenges of the utmost practical importance require long-term fundamental research. This presentation will address some of them, e.g., the effect of various ordering phenomena on activation barriers, and the strength and practical importance of correlation effects.

Basic Sciences Fertilizing Clinical Microbiology and Infection Management.

PubMed

Baquero, Fernando

2017-08-15

Basic sciences constitute the most abundant sources of creativity and innovation, as they are based on the passion of knowing. Basic knowledge, in close and fertile contact with medical and public health needs, produces distinct advancements in applied sciences. Basic sciences play the role of stem cells, providing material and semantics to construct differentiated tissues and organisms and enabling specialized functions and applications. However, eventually processes of "practice deconstruction" might reveal basic questions, as in de-differentiation of tissue cells. Basic sciences, microbiology, infectious diseases, and public health constitute an epistemological gradient that should also be an investigational continuum. The coexistence of all these interests and their cross-fertilization should be favored by interdisciplinary, integrative research organizations working simultaneously in the analytical and synthetic dimensions of scientific knowledge. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

Introduction to Pharmaceutical Biotechnology, Volume 1; Basic techniques and concepts

NASA Astrophysics Data System (ADS)

Bhatia, Saurabh; Goli, Divakar

2018-05-01

Animal biotechnology is a broad field including polarities of fundamental and applied research, as well as DNA science, covering key topics of DNA studies and its recent applications. In Introduction to Pharmaceutical Biotechnology, DNA isolation procedures followed by molecular markers and screening methods of the genomic library are explained. Interesting areas like isolation, sequencing and synthesis of genes, with the broader coverage on synthesis of genes, are also described. The book begins with an introduction to biotechnology and its main branches, explaining both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It then moves on to historical development and scope of biotechnology with an overall review of early applications that scientists employed long before the field was defined.

24 CFR 599.203 - Basic application submission requirements.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Basic application submission... Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND DEVELOPMENT, DEPARTMENT OF... Renewal Communities § 599.203 Basic application submission requirements. The basic application submission...

Proteomic approaches and their application to plant gravitropism.

PubMed

Basu, Proma; Luesse, Darron R; Wyatt, Sarah E

2015-01-01

Proteomics is a powerful technique that allows researchers a window into how an organism responds to a mutation, a specific environment, or at a distinct point during development by quantifying relative protein abundance and posttranslational modifications. Here, we describe methods for the proteomic analysis of Arabidopsis thaliana tissue. Extraction protocols are provided for isolation of soluble, plasma membrane, and tonoplast proteins. In addition, basic analysis and quality metrics for MS/MS data are discussed. The protocols outlined have the potential to unlock new avenues of research that are not possible through basic genetics or transcriptomic approaches. By combining proteomic information with known gene regulatory patterns, researchers can gain a complete picture of how molecular pathways, such as those required for gravitropism, are initiated, regulated, and terminated.

Industrial applications of the microgravity environment

NASA Technical Reports Server (NTRS)

1988-01-01

Opportunities for commercialization of the microgravity environment will depend upon the success of basic research projects performed in space. Significant demands for manufacturing opportunities are unlikely in the near term. The microgravity environment is to be considered primarily as a tool for research and secondarily as a manufacturing site. This research tool is unique, valuable, and presently available to U.S. investigators only through resources provided by NASA. The United States has an obligation to facilitate corporate research, maintain a flexible international policy, foster use of and assure access to a wide variety of facilities, and develop a posture of national and international leadership in and stewardship of research and materials processing in the microgravity environment. The National Research Council's Committee on Industrial Applications of the Microgravity Environment recommends six actions that strengthen this posture, including the formation of an authoritative organization to oversee the implementation of a program of microgravity research and its industrial applications.

Large space structures controls research and development at Marshall Space Flight Center: Status and future plans

NASA Technical Reports Server (NTRS)

Buchanan, H. J.

1983-01-01

Work performed in Large Space Structures Controls research and development program at Marshall Space Flight Center is described. Studies to develop a multilevel control approach which supports a modular or building block approach to the buildup of space platforms are discussed. A concept has been developed and tested in three-axis computer simulation utilizing a five-body model of a basic space platform module. Analytical efforts have continued to focus on extension of the basic theory and subsequent application. Consideration is also given to specifications to evaluate several algorithms for controlling the shape of Large Space Structures.

Donald J. Cram, Host-Guest Chemistry, Cram's Rule of Asymmetric Induction

Science.gov Websites

across organic chemistry, with applications in both basic research as well as specific fields, such as for life and science have forever changed "teaching in organic chemistry, and altered the shape organic chemistry; his research affects the many ways organic chemistry now appears in our daily lives

The Science Workbook of Student Research Projects in Food - Agriculture - Natural Resources.

ERIC Educational Resources Information Center

Darrow, Edward E., Ed.

This workbook provides descriptions of research projects for high school and middle school science teachers and students. The projects can be used as demonstrations in the laboratory or classroom to help teachers illustrate the practical application of basic science principles. They can also be used by students, under the guidance of the teachers,…

40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Section 26.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Evaluation and disposition of...

40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2012 CFR

2012-07-01

... Section 26.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Evaluation and disposition of...

40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2013 CFR

2013-07-01

... Section 26.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Evaluation and disposition of...

40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2014 CFR

2014-07-01

... Section 26.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Evaluation and disposition of...

40 CFR 26.120 - Evaluation and disposition of applications and proposals for research to be conducted or...

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Evaluation and disposition of... Section 26.120 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL PROTECTION OF HUMAN SUBJECTS Basic EPA Policy for Protection of Subjects in Human Research Conducted or Supported by EPA § 26...

Currency arbitrage detection using a binary integer programming model

NASA Astrophysics Data System (ADS)

Soon, Wanmei; Ye, Heng-Qing

2011-04-01

In this article, we examine the use of a new binary integer programming (BIP) model to detect arbitrage opportunities in currency exchanges. This model showcases an excellent application of mathematics to the real world. The concepts involved are easily accessible to undergraduate students with basic knowledge in Operations Research. Through this work, students can learn to link several types of basic optimization models, namely linear programming, integer programming and network models, and apply the well-known sensitivity analysis procedure to accommodate realistic changes in the exchange rates. Beginning with a BIP model, we discuss how it can be reduced to an equivalent but considerably simpler model, where an efficient algorithm can be applied to find the arbitrages and incorporate the sensitivity analysis procedure. A simple comparison is then made with a different arbitrage detection model. This exercise helps students learn to apply basic Operations Research concepts to a practical real-life example, and provides insights into the processes involved in Operations Research model formulations.

Synthesis of cell-penetrating peptides and their application in neurobiology.

PubMed

Dietz, Gunnar P H; Bähr, Mathias

2007-01-01

Short basic amino acid sequences, often called cell-penetrating peptides (CPPs), allow the delivery of proteins and other molecules into cells and across the blood-brain barrier (BBB). Although the ability of basic proteins to facilitate such trafficking is known for a long time, only the application of genetic methods and overexpression of fusion proteins in Escherichia coli has lead to a wide application of CPP in many research areas, including signal transduction, cancer, angiogenesis, apoptosis, bone development, cardioprotection, cell cycle, neurobiology, and many others. For the neuroscientist, CPPs are particularly attractive, as a number of articles in the last 5 years have reported their use for neuronal rescue in a number of models for neurodegenerative diseases in vitro and in vivo in rats, mice, or gerbils. Here, we give a detailed description of the protein purification methodology and applications in neuroscience.

Baseline Skills Assessment of the US Army Research Laboratory

DTIC Science & Technology

2015-01-01

level definitions Level Definition 1 Basic understanding, minimal experience 2 More specific understanding, some level of application 3 Expertise...polymers 1 Energy absorbers 2 Computational material modeling 1 Powder metallurgy 1 Tribology 1 Non-destructive inspection 1 Advanced

Feasibility and applications of RFID technologies to support Right-of-Way functions : technical report

DOT National Transportation Integrated Search

2010-08-01

Radio frequency identification device (RFID) technology provides the capability to store a unique identification : number and some basic attribute information, which can be retrieved wirelessly. This research project studied : the feasibility of usin...

POLLUTION PREVENTION RESEARCH ONGOING - EPA'S RISK REDUCTION ENGINEERING LABORATORY

EPA Science Inventory

The mission of the Risk Reduction Engineering Laboratory is to advance the understanding, development and application of engineering solutions for the prevention or reduction of risks from environmental contamination. This mission is accomplished through basic and applied researc...

Emerging Applications of Liquid Crystals Based on Nanotechnology

PubMed Central

Sohn, Jung Inn; Hong, Woong-Ki; Choi, Su Seok; Coles, Harry J.; Welland, Mark E.; Cha, Seung Nam; Kim, Jong Min

2014-01-01

Diverse functionalities of liquid crystals (LCs) offer enormous opportunities for their potential use in advanced mobile and smart displays, as well as novel non-display applications. Here, we present snapshots of the research carried out on emerging applications of LCs ranging from electronics to holography and self-powered systems. In addition, we will show our recent results focused on the development of new LC applications, such as programmable transistors, a transparent and active-type two-dimensional optical array and self-powered display systems based on LCs, and will briefly discuss their novel concepts and basic operating principles. Our research will give insights not only into comprehensively understanding technical and scientific applications of LCs, but also developing new discoveries of other LC-based devices. PMID:28788555

Learning theories 101: application to everyday teaching and scholarship.

PubMed

Kay, Denise; Kibble, Jonathan

2016-03-01

Shifts in educational research, in how scholarship in higher education is defined, and in how funding is appropriated suggest that educators within basic science fields can benefit from increased understanding of learning theory and how it applies to classroom practice. This article uses a mock curriculum design scenario as a framework for the introduction of five major learning theories. Foundational constructs and principles from each theory and how they apply to the proposed curriculum designs are described. A summative table that includes basic principles, constructs, and classroom applications as well as the role of the teacher and learner is also provided for each theory. Copyright © 2016 The American Physiological Society.

National Geospatial-Intelligence Agency Academic Research Program

NASA Astrophysics Data System (ADS)

Loomer, S. A.

2004-12-01

"Know the Earth.Show the Way." In fulfillment of its vision, the National Geospatial-Intelligence Agency (NGA) provides geospatial intelligence in all its forms and from whatever source-imagery, imagery intelligence, and geospatial data and information-to ensure the knowledge foundation for planning, decision, and action. To achieve this, NGA conducts a multi-disciplinary program of basic research in geospatial intelligence topics through grants and fellowships to the leading investigators, research universities, and colleges of the nation. This research provides the fundamental science support to NGA's applied and advanced research programs. The major components of the NGA Academic Research Program (NARP) are: - NGA University Research Initiatives (NURI): Three-year basic research grants awarded competitively to the best investigators across the US academic community. Topics are selected to provide the scientific basis for advanced and applied research in NGA core disciplines. - Historically Black College and University - Minority Institution Research Initiatives (HBCU-MI): Two-year basic research grants awarded competitively to the best investigators at Historically Black Colleges and Universities, and Minority Institutions across the US academic community. - Director of Central Intelligence Post-Doctoral Research Fellowships: Fellowships providing access to advanced research in science and technology applicable to the intelligence community's mission. The program provides a pool of researchers to support future intelligence community needs and develops long-term relationships with researchers as they move into career positions. This paper provides information about the NGA Academic Research Program, the projects it supports and how other researchers and institutions can apply for grants under the program.

Application of Platelet-Rich Plasma to Disorders of the Knee Joint

PubMed Central

Mandelbaum, Bert R.; McIlwraith, C. Wayne

2013-01-01

Importance. The promising therapeutic potential and regenerative properties of platelet-rich plasma (PRP) have rapidly led to its widespread clinical use in musculoskeletal injury and disease. Although the basic scientific rationale surrounding PRP products is compelling, the clinical application has outpaced the research. Objective. The purpose of this article is to examine the current concepts around the basic science of PRP application, different preparation systems, and clinical application of PRP in disorders in the knee. Evidence Acquisition. A systematic search of PubMed for studies that evaluated the basic science, preparation and clinical application of platelet concentrates was performed. The search used terms, including platelet-rich plasma or PRP preparation, activation, use in the knee, cartilage, ligament, and meniscus. Studies found in the initial search and related studies were reviewed. Results. A comprehensive review of the literature supports the potential use of PRP both nonoperatively and intraoperatively, but highlights the absence of large clinical studies and the lack of standardization between method, product, and clinical efficacy. Conclusions and Relevance. In addition to the call for more randomized, controlled clinical studies to assess the clinical effect of PRP, at this point, it is necessary to investigate PRP product composition and eventually have the ability to tailor the therapeutic product for specific indications. PMID:26069674

A team public health research project for first-year pharmacy students to apply content from didactic courses.

PubMed

Fuentes, David; Deguire, Nancy; Patel, Rajul; Boyce, Eric

2010-08-10

To implement and assess a first-year pharmacy student group research project that provided practical hands-on application and reinforced the curricula of concurrent didactic courses. Groups of 6 to 7 students chose a public health topic based on the Healthy People 2010 Priority Areas and created a survey instrument. Faculty facilitated mock institutional review board (IRB) review sessions which provided teams with ongoing feedback and refinement recommendations before each team administered their survey instrument to a predefined population. Data analysis, formal written reports, and oral presentations were presented to peers and project faculty members. Teams complied with the requirements of the mock IRB, effectively applied basic research principles learned in class, collected survey data, performed inferential statistical analyses on the data, , and presented their project findings. Two-hundred six of 210 students (98%) reported feeling satisfied with both the results of their project and the accomplishments of their team. Teams applied a varied skill set including primary literature evaluation, basic research principles, statistics, public speaking, and peer collaboration in conducting a public health research project. First-year pharmacy students may benefit from participation in a collaborative research project that provides hands-on application of material being taught in didactic courses.

General purpose optimization software for engineering design

NASA Technical Reports Server (NTRS)

Vanderplaats, G. N.

1990-01-01

The author has developed several general purpose optimization programs over the past twenty years. The earlier programs were developed as research codes and served that purpose reasonably well. However, in taking the formal step from research to industrial application programs, several important lessons have been learned. Among these are the importance of clear documentation, immediate user support, and consistent maintenance. Most important has been the issue of providing software that gives a good, or at least acceptable, design at minimum computational cost. Here, the basic issues developing optimization software for industrial applications are outlined and issues of convergence rate, reliability, and relative minima are discussed. Considerable feedback has been received from users, and new software is being developed to respond to identified needs. The basic capabilities of this software are outlined. A major motivation for the development of commercial grade software is ease of use and flexibility, and these issues are discussed with reference to general multidisciplinary applications. It is concluded that design productivity can be significantly enhanced by the more widespread use of optimization as an everyday design tool.

Evaluation of research in biomedical ontologies

PubMed Central

Dumontier, Michel; Gkoutos, Georgios V.

2013-01-01

Ontologies are now pervasive in biomedicine, where they serve as a means to standardize terminology, to enable access to domain knowledge, to verify data consistency and to facilitate integrative analyses over heterogeneous biomedical data. For this purpose, research on biomedical ontologies applies theories and methods from diverse disciplines such as information management, knowledge representation, cognitive science, linguistics and philosophy. Depending on the desired applications in which ontologies are being applied, the evaluation of research in biomedical ontologies must follow different strategies. Here, we provide a classification of research problems in which ontologies are being applied, focusing on the use of ontologies in basic and translational research, and we demonstrate how research results in biomedical ontologies can be evaluated. The evaluation strategies depend on the desired application and measure the success of using an ontology for a particular biomedical problem. For many applications, the success can be quantified, thereby facilitating the objective evaluation and comparison of research in biomedical ontology. The objective, quantifiable comparison of research results based on scientific applications opens up the possibility for systematically improving the utility of ontologies in biomedical research. PMID:22962340

Review of Development Survey of Phase Change Material Models in Building Applications

PubMed Central

Akeiber, Hussein J.; Wahid, Mazlan A.; Hussen, Hasanen M.; Mohammad, Abdulrahman Th.

2014-01-01

The application of phase change materials (PCMs) in green buildings has been increasing rapidly. PCM applications in green buildings include several development models. This paper briefly surveys the recent research and development activities of PCM technology in building applications. Firstly, a basic description of phase change and their principles is provided; the classification and applications of PCMs are also included. Secondly, PCM models in buildings are reviewed and discussed according to the wall, roof, floor, and cooling systems. Finally, conclusions are presented based on the collected data. PMID:25313367

100 years of occupational safety research: From basic protections and work analysis to a multilevel view of workplace safety and risk.

PubMed

Hofmann, David A; Burke, Michael J; Zohar, Dov

2017-03-01

Starting with initiatives dating back to the mid-1800s, we provide a high-level review of the key trends and developments in the application of applied psychology to the field of occupational safety. Factory laws, basic worker compensation, and research on accident proneness comprised much of the early work. Thus, early research and practice very much focused on the individual worker, the design of their work, and their basic protection. Gradually and over time, the focus began to navigate further into the organizational context. One of the early efforts to broaden beyond the individual worker was a significant focus on safety-related training during the middle of the 20th century. Toward the latter years of the 20th century and continuing the move from the individual worker to the broader organizational context, there was a significant increase in leadership and organizational climate (safety climate) research. Ultimately, this resulted in the development of a multilevel model of safety culture/climate. After discussing these trends, we identify key conclusions and opportunities for future research. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Behavioral economics and empirical public policy.

PubMed

Hursh, Steven R; Roma, Peter G

2013-01-01

The application of economics principles to the analysis of behavior has yielded novel insights on value and choice across contexts ranging from laboratory animal research to clinical populations to national trends of global impact. Recent innovations in demand curve methods provide a credible means of quantitatively comparing qualitatively different reinforcers as well as quantifying the choice relations between concurrently available reinforcers. The potential of the behavioral economic approach to inform public policy is illustrated with examples from basic research, pre-clinical behavioral pharmacology, and clinical drug abuse research as well as emerging applications to public transportation and social behavior. Behavioral Economics can serve as a broadly applicable conceptual, methodological, and analytical framework for the development and evaluation of empirical public policy. © Society for the Experimental Analysis of Behavior.

Basic Visual Disciplines in Heritage Conservation: Outline of Selected Perspectives in Teaching and Learning

NASA Astrophysics Data System (ADS)

Lobovikov-Katz, A.

2017-08-01

Acknowledgement of the value of a basic freehand sketch by the information and communication community of researchers and developers brought about the advanced developments for the use of sketches as free input to complicated processes of computerized visualization, so as to make them more widely accessible. However, a sharp reduction and even exclusion of this and other basic visual disciplines from education in sciences, technology, engineering and architecture dramatically reduces the number of future users of such applications. The unique needs of conservation of cultural heritage pose specific challenges as well as encourage the formulation of innovative development tasks in related areas of information and communication technologies (ICT). This paper claims that the introduction of basic visual disciplines to both communities is essential to the effectiveness of integration of heritage conservation needs and the advanced ICT development of conservation value, and beyond. It provides an insight into the challenges and advantages of introducing these subjects in a relevant educational context, presents some examples of their teaching and learning in the modern environment, including e-learning, and sketches perspectives to their application.

Microfluidic tools for cell biological research

PubMed Central

Velve-Casquillas, Guilhem; Le Berre, Maël; Piel, Matthieu; Tran, Phong T.

2010-01-01

Summary Microfluidic technology is creating powerful tools for cell biologists to control the complete cellular microenvironment, leading to new questions and new discoveries. We review here the basic concepts and methodologies in designing microfluidic devices, and their diverse cell biological applications. PMID:21152269

Translating basic research into clinical practice or what else do we have to learn about olfactory ensheathing cells?

PubMed

Radtke, Christine; Wewetzer, Konstantin

2009-06-12

Olfactory ensheathing cells (OECs) are Schwann cell-like glial cells of the olfactory system that have been shown to promote axonal regeneration and remyelination in a variety of different lesion paradigms. It is still a matter of debate in how far OECs differ from Schwann cells regarding their regenerative potential and molecular setup. The fact that OECs have been already used for transplantation in humans may imply that the need of the hour is the fine-tuning of clinical application details rather than to cross the bridge between laboratory animal and man. Considering the therapeutic transplantation of OECs, however, the basic question to date is not 'how' to translate but rather 'what' to translate into clinical practice. The aim of the present article is to provide a summary of the current literature and to define the open issues relevant for translating basic research on OECs into clinical practice.

College Students Perceptions of Web-Based Leaning in Basic Mathematics Subject

NASA Astrophysics Data System (ADS)

Husna, H.; Septia, T.; Cesaria, A.

2018-04-01

With the emergence of the Internet, e-learning has increasingly become the promising solution that continues to grow day after day. Considering students’ perception toward e-learning is important in successful development of e-learning in higher education, since attitude of user towards application of information technology is one of the most effective factors. This study aims to determine students' perceptions of using basic math textbook for physics with web-based. Students' perceptions are closely related to their achievement. The learning media in accordance with the desire of students will make them motivated. This research is qualitative data analysis was done descriptively. The data obtained in this study comes from researchers as the main instrument, the data questionnaire and interview data is unstructured. The results are students' perceptions of using basic math textbook for physics with web-based are in the positive category.

When cloud computing meets bioinformatics: a review.

PubMed

Zhou, Shuigeng; Liao, Ruiqi; Guan, Jihong

2013-10-01

In the past decades, with the rapid development of high-throughput technologies, biology research has generated an unprecedented amount of data. In order to store and process such a great amount of data, cloud computing and MapReduce were applied to many fields of bioinformatics. In this paper, we first introduce the basic concepts of cloud computing and MapReduce, and their applications in bioinformatics. We then highlight some problems challenging the applications of cloud computing and MapReduce to bioinformatics. Finally, we give a brief guideline for using cloud computing in biology research.

The development of photoemission spectroscopy and its application to the study of semiconductor interfaces Observations on the interplay between basic and applied research (Welch Memorial Lecture)

NASA Technical Reports Server (NTRS)

Spicer, W. E.

1985-01-01

A sketch is given of the development of photoemission electron spectroscopy (PES) with emphasis on the author's own experience. Emphasis is placed: (1) on the period between 1958-1970; (2) on the various developments which were required for PES to emerge; and (3) on the strong interactions between applied/fundamental and knowledge/empirically based research. A more detailed discussion is given of the recent (1975-present) application of PES to study the interfaces of III-V semiconductors.

LANDSAT-4 TM image data quality analysis for energy-related applications

NASA Technical Reports Server (NTRS)

Wukelic, G. E.; Foote, H. P.

1983-01-01

LANDSAT-4 Thematic Mapper (TM) data performance and utility characteristics from an energy research and technology perspective is evaluated. The program focuses on evaluating applicational implications of using such data, in combination with other digital data, for current and future energy research and technology activities. Prime interest is in using TM data for siting, developing and operating federal energy facilities. Secondary interests involve the use of such data for resource exploration, environmental monitoring and basic scientific initiatives such as in support of the Continental Scientific Drilling Program.

Research relative to weather radar measurement techniques

NASA Technical Reports Server (NTRS)

Smith, Paul L.

1992-01-01

Research relative to weather radar measurement techniques, which involves some investigations related to measurement techniques applicable to meteorological radar systems in Thailand, is reported. A major part of the activity was devoted to instruction and discussion with Thai radar engineers, technicians, and meteorologists concerning the basic principles of radar meteorology and applications to specific problems, including measurement of rainfall and detection of wind shear/microburst hazards. Weather radar calibration techniques were also considered during this project. Most of the activity took place during two visits to Thailand, in December 1990 and February 1992.

A Dodecalogue of Basic Didactics from Applications of Abstract Differential Geometry to Quantum Gravity

NASA Astrophysics Data System (ADS)

Raptis, Ioannis

2007-12-01

We summarize the twelve most important in our view novel concepts that have arisen, based on results that have been obtained, from various applications of Abstract Differential Geometry (ADG) to Quantum Gravity (QG). The present document may be used as a concise, yet informal, discursive and peripatetic conceptual guide- cum-terminological glossary to the voluminous technical research literature on the subject. In a bonus section at the end, we dwell on the significance of introducing new conceptual terminology in future QG research by means of ‘poetic language’.

[Application of basic research to development of diagnostics and therapeutic agents against inflammatory diseases].

PubMed

Izuhara, Kenji; Ohta, Shoichiro; Arima, Kazuhiko; Suzuki, Shoichi; Inamitsu, Masako; Yamamoto, Ken-ichi

2013-10-01

Biomarkers are generally important for the treatment of patients from the points of diagnosis of disease, assessment of cure, assessment of prognosis such as metastasis or recurrence, prevention of disease, and prediction of drug efficacy. Currently it is well accepted that allergic diseases such as bronchial asthma and atopic dermatitis are not single diseases, but syndromes encompassing different diseases entities. Therefore, it is important to cluster allergic disease patients to assess prognosis or the choice of therapeutic drugs, and useful biomarkers are required for these purposes. Periostin, an extracellular matrix protein, has recently emerged as a biomarker useful for clustering asthma patients. We further found that periostin plays an important role in allergic inflammation and based on this finding we are now developing therapeutic agents targeting periostin against allergic diseases. Since periostin is involved in the pathogenesis of various inflammatory diseases in addition to allergic diseases, such diagnostics and therapeutic agents can be applied to many inflammatory diseases. In this article, we describe the history of periostin research and our application of basic research to the development of diagnostics and therapeutic agents against inflammatory diseases.

Applications of artificial intelligence to scientific research

NASA Technical Reports Server (NTRS)

Prince, Mary Ellen

1986-01-01

Artificial intelligence (AI) is a growing field which is just beginning to make an impact on disciplines other than computer science. While a number of military and commercial applications were undertaken in recent years, few attempts were made to apply AI techniques to basic scientific research. There is no inherent reason for the discrepancy. The characteristics of the problem, rather than its domain, determines whether or not it is suitable for an AI approach. Expert system, intelligent tutoring systems, and learning programs are examples of theoretical topics which can be applied to certain areas of scientific research. Further research and experimentation should eventurally make it possible for computers to act as intelligent assistants to scientists.

Future applications of artificial intelligence to Mission Control Centers

NASA Technical Reports Server (NTRS)

Friedland, Peter

1991-01-01

Future applications of artificial intelligence to Mission Control Centers are presented in the form of the viewgraphs. The following subject areas are covered: basic objectives of the NASA-wide AI program; inhouse research program; constraint-based scheduling; learning and performance improvement for scheduling; GEMPLAN multi-agent planner; planning, scheduling, and control; Bayesian learning; efficient learning algorithms; ICARUS (an integrated architecture for learning); design knowledge acquisition and retention; computer-integrated documentation; and some speculation on future applications.

ICASE semiannual report, April 1 - September 30, 1989

NASA Technical Reports Server (NTRS)

1990-01-01

The Institute conducts unclassified basic research in applied mathematics, numerical analysis, and computer science in order to extend and improve problem-solving capabilities in science and engineering, particularly in aeronautics and space. The major categories of the current Institute for Computer Applications in Science and Engineering (ICASE) research program are: (1) numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; (2) control and parameter identification problems, with emphasis on effective numerical methods; (3) computational problems in engineering and the physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and (4) computer systems and software, especially vector and parallel computers. ICASE reports are considered to be primarily preprints of manuscripts that have been submitted to appropriate research journals or that are to appear in conference proceedings.

Genome elimination: translating basic research into a future tool for plant breeding.

PubMed

Comai, Luca

2014-06-01

During the course of our history, humankind has been through different periods of agricultural improvement aimed at enhancing our food supply and the performance of food crops. In recent years, it has become apparent that future crop improvement efforts will require new approaches to address the local challenges of farmers while empowering discovery across industry and academia. New plant breeding approaches are needed to meet this challenge to help feed a growing world population. Here I discuss how a basic research discovery is being translated into a potential future tool for plant breeding, and share the story of researcher Simon Chan, who recognized the potential application of this new approach--genome elimination--for the breeding of staple food crops in Africa and South America.

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis.

PubMed

Heijman, Jordi; Algalarrondo, Vincent; Voigt, Niels; Melka, Jonathan; Wehrens, Xander H T; Dobrev, Dobromir; Nattel, Stanley

2016-04-01

Atrial fibrillation (AF) is an extremely common clinical problem associated with increased morbidity and mortality. Current antiarrhythmic options include pharmacological, ablation, and surgical therapies, and have significantly improved clinical outcomes. However, their efficacy remains suboptimal, and their use is limited by a variety of potentially serious adverse effects. There is a clear need for improved therapeutic options. Several decades of research have substantially expanded our understanding of the basic mechanisms of AF. Ectopic firing and re-entrant activity have been identified as the predominant mechanisms for arrhythmia initiation and maintenance. However, it has become clear that the clinical factors predisposing to AF and the cellular and molecular mechanisms involved are extremely complex. Moreover, all AF-promoting and maintaining mechanisms are dynamically regulated and subject to remodelling caused by both AF and cardiovascular disease. Accordingly, the initial presentation and clinical progression of AF patients are enormously heterogeneous. An understanding of arrhythmia mechanisms is widely assumed to be the basis of therapeutic innovation, but while this assumption seems self-evident, we are not aware of any papers that have critically examined the practical contributions of basic research into AF mechanisms to arrhythmia management. Here, we review recent insights into the basic mechanisms of AF, critically analyse the role of basic research insights in the development of presently used anti-AF therapeutic options and assess the potential value of contemporary experimental discoveries for future therapeutic innovation. Finally, we highlight some of the important challenges to the translation of basic science findings to clinical application. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

Co-authorship network analysis in health research: method and potential use.

PubMed

Fonseca, Bruna de Paula Fonseca E; Sampaio, Ricardo Barros; Fonseca, Marcus Vinicius de Araújo; Zicker, Fabio

2016-04-30

Scientific collaboration networks are a hallmark of contemporary academic research. Researchers are no longer independent players, but members of teams that bring together complementary skills and multidisciplinary approaches around common goals. Social network analysis and co-authorship networks are increasingly used as powerful tools to assess collaboration trends and to identify leading scientists and organizations. The analysis reveals the social structure of the networks by identifying actors and their connections. This article reviews the method and potential applications of co-authorship network analysis in health. The basic steps for conducting co-authorship studies in health research are described and common network metrics are presented. The application of the method is exemplified by an overview of the global research network for Chikungunya virus vaccines.

[Prospect and application of microsatellite population genetics in study of geoherbs].

PubMed

Zhang, Wen-Jing; Zhang, Yong-Qing; Yuan, Qing-Jun; Huang, Lu-Qi; Jiang, Dan; Jing, Li

2013-12-01

The author introduces the basic concepts of microsatellite and population genetics and its characteristics, expounds the application of these theories for population genetic structure and genetic diversity, gene flow and evolutionary significant unit ESU division research. This paper discuss its applicationin study of genetic causes, origin of cultivation, different regional origins of geoherbs, aiming at providing a new theory and method for geoherbs.

From School to Tertiary Study: Transition to College and University in Victoria. ACER Research Monograph No. 14.

ERIC Educational Resources Information Center

Elsworth, Gerald; And Others

A study of the transition of students to higher education in Victoria, Australia, is reported based on data supplied by the Victorian Universities Admissions Committee (VUAC), a mail survey of 1,300 applicants in 1980, and a series of extended interviews with a small number of applicants. A basic causal model for enrollment decisions (college…

Plasma medicine—current state of research and medical application

NASA Astrophysics Data System (ADS)

Weltmann, K.-D.; von Woedtke, Th

2017-01-01

Plasma medicine means the direct application of cold atmospheric plasma (CAP) on or in the human body for therapeutic purposes. Further, the field interacts strongly with results gained for biological decontamination. Experimental research as well as first practical application is realized using two basic principles of CAP sources: dielectric barrier discharges (DBD) and atmospheric pressure plasma jets (APPJ). Originating from the fundamental insights that the biological effects of CAP are most probably caused by changes of the liquid environment of cells, and are dominated by reactive oxygen and nitrogen species (ROS, RNS), basic mechanisms of biological plasma activity are identified. It was demonstrated that there is no increased risk of cold plasma application and, above all, there are no indications for genotoxic effects. The most important biological effects of cold atmospheric pressure plasma were identified: (1) inactivation of a broad spectrum of microorganisms including multidrug resistant ones; (2) stimulation of cell proliferation and tissue regeneration with lower plasma treatment intensity (treatment time); (3) inactivation of cells by initialization of programmed cell death (apoptosis) with higher plasma treatment intensity (treatment time). In recent years, the main focus of clinical applications was in the field of wound healing and treatment of infective skin diseases. First CAP sources are CE-certified as medical devices now which is the main precondition to start the introduction of plasma medicine into clinical reality. Plasma application in dentistry and, above all, CAP use for cancer treatment are becoming more and more important research fields in plasma medicine. A further in-depth knowledge of control and adaptation of plasma parameters and plasma geometries is needed to obtain suitable and reliable plasma sources for the different therapeutic indications and to open up new fields of medical application.

A Primer for Agent-Based Simulation and Modeling in Transportation Applications

DOT National Transportation Integrated Search

2013-11-01

Agent-based modeling and simulation (ABMS) methods have been applied in a spectrum of research domains. This primer focuses on ABMS in the transportation interdisciplinary domain, describes the basic concepts of ABMS and the recent progress of ABMS i...

Identification and application of criteria for determining National Register eligibility of roads in Virginia.

DOT National Transportation Integrated Search

2003-01-01

At present, there are no clear standards for applying National Register criteria to roads and for objectively researching and determining the National Register eligibility of roadways in Virginia. Basic historic documentation of Virginia roads is oft...

Modulation of intra- and inter-sheet interactions in short peptide self-assembly by acetonitrile in aqueous solution

NASA Astrophysics Data System (ADS)

Deng, Li; Zhao, Yurong; Zhou, Peng; Xu, Hai; Wang, Yanting

2016-12-01

Not Available Project supported by the National Basic Research Program of China (Grant No. 2013CB932804), the National Natural Science Foundation of China (Grant Nos. 91227115, 11421063, 11504431, and 21503275), the Fundamental Research Funds for Central Universities of China (Grant No. 15CX02025A), and the Application Research Foundation for Post-doctoral Scientists of Qingdao City, China (Grant No. T1404096).

Nuclear Reactor Physics

NASA Astrophysics Data System (ADS)

Stacey, Weston M.

2001-02-01

An authoritative textbook and up-to-date professional's guide to basic and advanced principles and practices Nuclear reactors now account for a significant portion of the electrical power generated worldwide. At the same time, the past few decades have seen an ever-increasing number of industrial, medical, military, and research applications for nuclear reactors. Nuclear reactor physics is the core discipline of nuclear engineering, and as the first comprehensive textbook and reference on basic and advanced nuclear reactor physics to appear in a quarter century, this book fills a large gap in the professional literature. Nuclear Reactor Physics is a textbook for students new to the subject, for others who need a basic understanding of how nuclear reactors work, as well as for those who are, or wish to become, specialists in nuclear reactor physics and reactor physics computations. It is also a valuable resource for engineers responsible for the operation of nuclear reactors. Dr. Weston Stacey begins with clear presentations of the basic physical principles, nuclear data, and computational methodology needed to understand both the static and dynamic behaviors of nuclear reactors. This is followed by in-depth discussions of advanced concepts, including extensive treatment of neutron transport computational methods. As an aid to comprehension and quick mastery of computational skills, he provides numerous examples illustrating step-by-step procedures for performing the calculations described and chapter-end problems. Nuclear Reactor Physics is a useful textbook and working reference. It is an excellent self-teaching guide for research scientists, engineers, and technicians involved in industrial, research, and military applications of nuclear reactors, as well as government regulators who wish to increase their understanding of nuclear reactors.

Recent trends in humanoid robotics research: scientific background, applications, and implications.

PubMed

Solis, Jorge; Takanishi, Atsuo

2010-11-01

Even though the market size is still small at this moment, applied fields of robots are gradually spreading from the manufacturing industry to the others as one of the important components to support an aging society. For this purpose, the research on human-robot interaction (HRI) has been an emerging topic of interest for both basic research and customer application. The studies are especially focused on behavioral and cognitive aspects of the interaction and the social contexts surrounding it. As a part of these studies, the term of "roboethics" has been introduced as an approach to discuss the potentialities and the limits of robots in relation to human beings. In this article, we describe the recent research trends on the field of humanoid robotics. Their principal applications and their possible impact are discussed.

Translational Epidemiology in Psychiatry

PubMed Central

Weissman, Myrna M.; Brown, Alan S.; Talati, Ardesheer

2012-01-01

Translational research generally refers to the application of knowledge generated by advances in basic sciences research translated into new approaches for diagnosis, prevention, and treatment of disease. This direction is called bench-to-bedside. Psychiatry has similarly emphasized the basic sciences as the starting point of translational research. This article introduces the term translational epidemiology for psychiatry research as a bidirectional concept in which the knowledge generated from the bedside or the population can also be translated to the benches of laboratory science. Epidemiologic studies are primarily observational but can generate representative samples, novel designs, and hypotheses that can be translated into more tractable experimental approaches in the clinical and basic sciences. This bedside-to-bench concept has not been explicated in psychiatry, although there are an increasing number of examples in the research literature. This article describes selected epidemiologic designs, providing examples and opportunities for translational research from community surveys and prospective, birth cohort, and family-based designs. Rapid developments in informatics, emphases on large sample collection for genetic and biomarker studies, and interest in personalized medicine—which requires information on relative and absolute risk factors—make this topic timely. The approach described has implications for providing fresh metaphors to communicate complex issues in interdisciplinary collaborations and for training in epidemiology and other sciences in psychiatry. PMID:21646577

The Empirical Foundations of Telepathology: Evidence of Feasibility and Intermediate Effects

PubMed Central

Krupinski, Elizabeth A.; Weinstein, Ronald S.; Dunn, Matthew R.; Bashshur, Noura

2017-01-01

Abstract Introduction: Telepathology evolved from video microscopy (i.e., “television microscopy”) research in the early 1950s to video microscopy used in basic research in the biological sciences to a basic diagnostic tool in telemedicine clinical applications. Its genesis can be traced to pioneering feasibility studies regarding the importance of color and other image-based parameters for rendering diagnoses and a series of studies assessing concordance of virtual slide and light microscopy diagnoses. This article documents the empirical foundations of telepathology. Methods: A selective review of the research literature during the past decade (2005–2016) was conducted using robust research design and adequate sample size as criteria for inclusion. Conclusions: The evidence regarding feasibility/acceptance of telepathology and related information technology applications has been well documented for several decades. The majority of evidentiary studies focused on intermediate outcomes, as indicated by comparability between telepathology and conventional light microscopy. A consistent trend of concordance between the two modalities was observed in terms of diagnostic accuracy and reliability. Additional benefits include use of telepathology and whole slide imaging for teaching, research, and outreach to resource-limited countries. Challenges still exist, however, in terms of use of telepathology as an effective diagnostic modality in clinical practice. PMID:28170313

General Motors and the University of Michigan smart materials and structures collaborative research laboratory

NASA Astrophysics Data System (ADS)

Brei, Diann; Luntz, Jonathan; Shaw, John; Johnson, Nancy L.; Browne, Alan L.; Alexander, Paul W.; Mankame, Nilesh D.

2007-04-01

The field of Smart Materials and Structures is evolving from high-end, one-of-a-kind products for medical, military and aerospace applications to the point of viability for mainstream affordable high volume products for automotive applications. For the automotive industry, there are significant potential benefits to be realized including reduction in vehicle mass, added functionality and design flexibility and decrease in component size and cost. To further accelerate the path from basic research and development to launched competitive products, General Motors (GM) has teamed with the College of Engineering at the University of Michigan (UM) to establish a $2.9 Million Collaborative Research Laboratory (CRL) in Smart Materials and Structures. Researchers at both GM and UM are working closely together to create leap-frog technologies which start at conceptualization and proceed all the way through demonstration and handoff to product teams, thereby bridging the traditional technology gap between industry and academia. In addition to Smart Device Technology Innovation, other thrust areas in the CRL include Smart Material Maturity with a basic research focus on overcoming material issues that form roadblocks to commercialism and Mechamatronic System Design Methodology with an applied focus on development tools (synthesis and analysis) to aid the engineer in application of smart materials to system engineering. This CRL is a global effort with partners across the nation and world from GM's Global Research Network such as HRL Laboratories in California and GM's India Science Lab in Bangalore, India. This paper provides an overview of this new CRL and gives examples of several of the projects underway.

The 2013 Clusters, Nanocrystals & Nanostructures Gordon Research Conference/Gordon Research Seminar

DOE Office of Scientific and Technical Information (OSTI.GOV)

Krauss, Todd D.

The fundamental properties of small particles and their potential for groundbreaking applications are among the most exciting areas of study in modern physics, chemistry, and materials science. The Clusters, Nanocrystals & Nanostructures Gordon ResearchConference and Gordon Research Seminar synthesize contributions from these inter-related fields that reflect the pivotal role of nano-particles at the interface between these disciplines. Size-dependent optical, electronic, magnetic and catalytic properties offer prospects for applications in many fields, and possible solutions for many of the grand challenges facing energy generation, consumption, delivery, and storage in the 21st century. The goal of the 2013 Clusters, Nanocrystals & Nanostructuresmore » Gordon Research Conference and Gordon Research Seminar is to continue the historical interdisciplinary tradition of this series and discuss the most recent advances, basic scientific questions, and emerging applications of clusters, nanocrystals, and nanostructures. The Clusters, Nanocrystals & Nanostructures GRC/GRS traditionally brings together the leading scientific groups that have made significant recent advances in one or more fundamental nanoscience or nanotechnology areas. Broad interests of the DOE BES and Solar Photochemistry Program addressed by this meeting include the areas of solar energy to fuels conversion, new photovoltaic systems, fundamental characterization of nanomaterials, magnetism, catalysis, and quantum physics. The vast majority of speakers and attendees will address either directly the topic of nanotechnology for photoinduced charge transfer, charge transport, and catalysis, or will have made significant contributions to related areas that will impact these fields indirectly. These topics have direct relevance to the mission of the DOE BES since it is this cutting-edge basic science that underpins our energy future.« less

FRED 2: an immunoinformatics framework for Python

PubMed Central

Schubert, Benjamin; Walzer, Mathias; Brachvogel, Hans-Philipp; Szolek, András; Mohr, Christopher; Kohlbacher, Oliver

2016-01-01

Summary: Immunoinformatics approaches are widely used in a variety of applications from basic immunological to applied biomedical research. Complex data integration is inevitable in immunological research and usually requires comprehensive pipelines including multiple tools and data sources. Non-standard input and output formats of immunoinformatics tools make the development of such applications difficult. Here we present FRED 2, an open-source immunoinformatics framework offering easy and unified access to methods for epitope prediction and other immunoinformatics applications. FRED 2 is implemented in Python and designed to be extendable and flexible to allow rapid prototyping of complex applications. Availability and implementation: FRED 2 is available at http://fred-2.github.io Contact: schubert@informatik.uni-tuebingen.de Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27153717

FRED 2: an immunoinformatics framework for Python.

PubMed

Schubert, Benjamin; Walzer, Mathias; Brachvogel, Hans-Philipp; Szolek, András; Mohr, Christopher; Kohlbacher, Oliver

2016-07-01

Immunoinformatics approaches are widely used in a variety of applications from basic immunological to applied biomedical research. Complex data integration is inevitable in immunological research and usually requires comprehensive pipelines including multiple tools and data sources. Non-standard input and output formats of immunoinformatics tools make the development of such applications difficult. Here we present FRED 2, an open-source immunoinformatics framework offering easy and unified access to methods for epitope prediction and other immunoinformatics applications. FRED 2 is implemented in Python and designed to be extendable and flexible to allow rapid prototyping of complex applications. FRED 2 is available at http://fred-2.github.io schubert@informatik.uni-tuebingen.de Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

Application of a Novel Laser-Doppler Velocimeter for Turbulence: Structural Measurements in Turbulent Boundary Layers

DTIC Science & Technology

2006-10-18

Research of the Nat. Bur. of Standards, Research Papaer RP2388, pp. 51-62. Tennekes H and Lumley JL. 1972 A First Course in Turbulence, The MIT Press...24061-0203 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSORING/MONITORING AGENCY Air Force Office of Scientific Research REPORT NUMBER...complex and difficult to predict, even for the most basic situations. Fundamental turbulence research continues to be necessary in order to advance our

CRC Clinical Trials Management System (CTMS): An Integrated Information Management Solution for Collaborative Clinical Research

PubMed Central

Payne, Philip R.O.; Greaves, Andrew W.; Kipps, Thomas J.

2003-01-01

The Chronic Lymphocytic Leukemia (CLL) Research Consortium (CRC) consists of 9 geographically distributed sites conducting a program of research including both basic science and clinical components. To enable the CRC’s clinical research efforts, a system providing for real-time collaboration was required. CTMS provides such functionality, and demonstrates that the use of novel data modeling, web-application platforms, and management strategies provides for the deployment of an extensible, cost effective solution in such an environment. PMID:14728471

Research progress on laser crystals in China

NASA Astrophysics Data System (ADS)

Yingxia, Z.

1985-01-01

Current Chinese research on laser crystals is now quite extensive and involves more than 30 research teams with nearly 1,000 technicians and workers actively engaged in the study of more than 20 types of laser cyrstals. Neodymium-doped yttrium aluminum garnet (Nd:YAG) and ruby (Cr:Al2O3) lasers have been manufactured and are widely employed. There are several new and promising crystals now under study which will find applications, and both basic and exploratory research have given rise to new developments.

PREFACE: 2nd International Conference and Young Scientist School ''Magnetic resonance imaging in biomedical research''

NASA Astrophysics Data System (ADS)

Naumova, A. V.; Khodanovich, M. Y.; Yarnykh, V. L.

2016-02-01

The Second International Conference and Young Scientist School ''Magnetic resonance imaging in biomedical research'' was held on the campus of the National Research Tomsk State University (Tomsk, Russia) on September 7-9, 2015. The conference was focused on magnetic resonance imaging (MRI) applications for biomedical research. The main goal was to bring together basic scientists, clinical researchers and developers of new MRI techniques to bridge the gap between clinical/research needs and advanced technological solutions. The conference fostered research and development in basic and clinical MR science and its application to health care. It also had an educational purpose to promote understanding of cutting-edge MR developments. The conference provided an opportunity for researchers and clinicians to present their recent theoretical developments, practical applications, and to discuss unsolved problems. The program of the conference was divided into three main topics. First day of the conference was devoted to educational lectures on the fundamentals of MRI physics and image acquisition/reconstruction techniques, including recent developments in quantitative MRI. The second day was focused on developments and applications of new contrast agents. Multinuclear and spectroscopic acquisitions as well as functional MRI were presented during the third day of the conference. We would like to highlight the main developments presented at the conference and introduce the prominent speakers. The keynote speaker of the conference Dr. Vasily Yarnykh (University of Washington, Seattle, USA) presented a recently developed MRI method, macromolecular proton fraction (MPF) mapping, as a unique tool for modifying image contrast and a unique tool for quantification of the myelin content in neural tissues. Professor Yury Pirogov (Lomonosov Moscow State University) described development of new fluorocarbon compounds and applications for biomedicine. Drs. Julia Velikina and Alexey Samsonov (University of Wisconsin-Madison, USA) demonstrated new image reconstruction methods for accelerated quantitative parameter mapping and magnetic resonance angiography. Finally, we would like to thank the scientific committee, the local organizing committee and the National Research Tomsk State University for giving an opportunity to share scientific ideas and new developments at the conference and the Russian Science Foundation (project № 14-45-00040) for financial support.

TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge.

PubMed

Casas, Caty; Codogno, Patrice; Pinti, Marcello; Batoko, Henri; Morán, María; Proikas-Cezanne, Tassula; Reggiori, Fulvio; Sirko, Agnieszka; Soengas, María S; Velasco, Guillermo; Lafont, Frank; Lane, Jon; Faure, Mathias; Cossarizza, Andrea

2016-01-01

A collaborative consortium, named "TRANSAUTOPHAGY," has been created among European research groups, comprising more than 150 scientists from 21 countries studying diverse branches of basic and translational autophagy. The consortium was approved in the framework of the Horizon 2020 Program in November 2015 as a COST Action of the European Union (COST means: CO-operation in Science and Technology), and will be sponsored for 4 years. TRANSAUTOPHAGY will form an interdisciplinary platform for basic and translational researchers, enterprises and stakeholders of diverse disciplines (including nanotechnology, bioinformatics, physics, chemistry, biology and various medical disciplines). TRANSAUTOPHAGY will establish 5 different thematic working groups, formulated to cooperate in research projects, share ideas, and results through workshops, meetings and short term exchanges of personnel (among other initiatives). TRANSAUTOPHAGY aims to generate breakthrough multidisciplinary knowledge about autophagy regulation, and to boost translation of this knowledge into biomedical and biotechnological applications.

TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge

PubMed Central

Casas, Caty; Codogno, Patrice; Pinti, Marcello; Batoko, Henri; Morán, María; Proikas-Cezanne, Tassula; Reggiori, Fulvio; Sirko, Agnieszka; Soengas, María S; Velasco, Guillermo; Lafont, Frank; Lane, Jon; Faure, Mathias; Cossarizza, Andrea

2016-01-01

abstract A collaborative consortium, named “TRANSAUTOPHAGY,” has been created among European research groups, comprising more than 150 scientists from 21 countries studying diverse branches of basic and translational autophagy. The consortium was approved in the framework of the Horizon 2020 Program in November 2015 as a COST Action of the European Union (COST means: CO-operation in Science and Technology), and will be sponsored for 4 years. TRANSAUTOPHAGY will form an interdisciplinary platform for basic and translational researchers, enterprises and stakeholders of diverse disciplines (including nanotechnology, bioinformatics, physics, chemistry, biology and various medical disciplines). TRANSAUTOPHAGY will establish 5 different thematic working groups, formulated to cooperate in research projects, share ideas, and results through workshops, meetings and short term exchanges of personnel (among other initiatives). TRANSAUTOPHAGY aims to generate breakthrough multidisciplinary knowledge about autophagy regulation, and to boost translation of this knowledge into biomedical and biotechnological applications. PMID:27046256

Town Meeting on Plasma Physics at the National Science Foundation

NASA Astrophysics Data System (ADS)

2015-11-01

We invite you to the Town Meeting on the role of the National Science Foundation (NSF) in supporting basic and applied research in Plasma Physics in the U.S. The overarching goal of NSF is to promote the progress of science and to enable training of the next generation of scientists and engineers at US colleges and universities. In this context, the role of the NSF Physics Division in leading the nearly 20 year old NSF/DOE Partnership in Basic Plasma Science and Engineering serves as an example of the long history of NSF support for basic plasma physics research. Yet, the NSF interest in maintaining a healthy university research base in plasma sciences extends across the Foundation. A total of five NSF Divisions are participating in the most recent Partnership solicitation, and a host of other multi-disciplinary and core programs provide opportunities for scientists to perform research on applications of plasma physics to Space & Solar Physics, Astrophysics, Accelerator Science, Material Science, Plasma Medicine, and many sub-disciplines within Engineering. This Town Meeting will provide a chance to discuss the full range of relevant NSF funding opportunities, and to begin a conversation on the present and future role of NSF in stewarding basic plasma science and engineering research at US colleges and universities. We would like to particularly encourage early career scientists and graduate students to participate in this Town Meeting, though everyone is invited to join what we hope to be a lively discussion.

Positron Emission Tomography: Principles, Technology, and Recent Developments

NASA Astrophysics Data System (ADS)

Ziegler, Sibylle I.

2005-04-01

Positron emission tomography (PET) is a nuclear medical imaging technique for quantitative measurement of physiologic parameters in vivo (an overview of principles and applications can be found in [P.E. Valk, et al., eds. Positron Emission Tomography. Basic Science and Clinical Practice. 2003, Springer: Heidelberg]), based on the detection of small amounts of posi-tron-emitter-labelled biologic molecules. Various radiotracers are available for neuro-logical, cardiological, and oncological applications in the clinic and in research proto-cols. This overview describes the basic principles, technology, and recent develop-ments in PET, followed by a section on the development of a tomograph with ava-lanche photodiodes dedicated for small animal imaging as an example of efforts in the domain of high resolution tomographs.

Recent advances in basic and clinical nanomedicine.

PubMed

Morrow, K John; Bawa, Raj; Wei, Chiming

2007-09-01

Nanomedicine is a global business enterprise. Industry and governments clearly are beginning to envision nanomedicine's enormous potential. A clear definition of nanotechnology is an issue that requires urgent attention. This problem exists because nanotechnology represents a cluster of technologies, each of which may have different characteristics and applications. Although numerous novel nanomedicine-related applications are under development or nearing commercialization, the process of converting basic research in nanomedicine into commercially viable products will be long and difficult. Although realization of the full potential of nanomedicine may be years or decades away, recent advances in nanotechnology-related drug delivery, diagnosis, and drug development are beginning to change the landscape of medicine. Site-specific targeted drug delivery and personalized medicine are just a few concepts that are on the horizon.

Constructing an ethical framework for embryo donation to research: is it time for a restricted consent policy?

PubMed

Ehrich, Kathryn; Farsides, Bobbie; Williams, Clare; Scott, Rosamund

2011-06-01

An Ethics & Policy Workshop was held with 20 invited UK stakeholders to consider whether embryo donors should be able to restrict the future use of human embryonic stem cells (hESCs) created from their embryos. Participants cited tensions between pure altruism and a more reciprocal basis for donation; and between basic research (in which genetic material would never form part of another living being) and treatment applications. Two restriction models were suggested to acknowledge specific ethical issues raised by hESCs' use in research and treatments: (1) a two tier system: hESCs with unrestricted consent could go to the UK Stem Cell Bank; those with restricted consent could be used in individual labs which could guarantee to honour the restrictions, and Bank deposit would not be required. (2) a three category system: restrictions could include (i) basic hESC research; (ii) hESC research and treatment; no gamete derivation (iii) 'unrestricted' hESC research and treatment.

Application for certification 1988 model year light-duty vehicles - US Technical Research Company (Peugeot)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

Every year, each manufacturer of passenger cars, light-duty trucks, motorcycles, or heavy-duty engines submits to EPA an application for certification. In the application, the manufacturer gives a detailed technical description of the vehicles or engines he intends to market during the upcoming model year. These engineering data include explanations and/or drawings that describe engine/vehicle parameters such as basic engine design, fuel systems, ignition systems, and exhaust and evaporative emission control systems.

[Analysis of master degree thesis of otolaryngology head and neck surgery in Xinjiang].

PubMed

Ayiheng, Qukuerhan; Niliapaer, Alimu; Yalikun, Yasheng

2010-12-01

To understand the basic situation and development of knowledge structure and ability of master degree of Otolaryngology Head and Neck Surgery in Xinjiang region in order to provide reference to further improve the quality of postgraduate students. Fourty-six papers of Otolaryngology master degree thesis were reviewed at randomly in terms of types, subject selection ranges as well as statistical methods during 1998-2009 in Xinjiang region in order to analyze and explore its advantages and characteristics and suggest a solution for its disadvantages. In 46 degree thesis, nine of them are scientific dissertations accounting for 19.57%, 37 are clinical professional degree thesis, accounting for 80.43%. Five are Experimental research papers, 30 are clinical research papers, 10 are clinical and experimental research papers, 1 of them is experimental epidemiology research paper; in this study, the kinds of diseases including every subject of ENT, various statistical methods are involved; references are 37.46 in average, 19.55 of them are foreign literatures references in nearly 5 years are 13.57; four ethnic groups are exist in postgraduate students with high teaching professional level of tutors. The clinical research should be focused in order to further research on ENT common diseases, the application of advanced research methods, the full application of the latest literature, tutors with high-level, training of students of various nationalities, basic research needs to be innovative and should be focus the subject characteristics, to avoid excessive duplication of research.

Cosmological Entropy Bounds

NASA Astrophysics Data System (ADS)

Brustein, R.

I review some basic facts about entropy bounds in general and about cosmological entropy bounds. Then I review the causal entropy bound, the conditions for its validity and its application to the study of cosmological singularities. This article is based on joint work with Gabriele Veneziano and subsequent related research.

Cape Wind: A Public Policy Debate for the Physical Sciences

ERIC Educational Resources Information Center

Mayer, Shannon

2007-01-01

Since the industrial revolution, technological innovation and the application of basic scientific research have transformed society. Increasingly, critical conversations and legislation regarding national and international public policy have sophisticated scientific underpinnings. It is crucial that we prepare scientists and engineers with an…

Reflectiveness/Impulsiveness and Mathematics Achievement

ERIC Educational Resources Information Center

Cathcart, W. George; Liedtke, Werner

1969-01-01

Report of research to test the hypothesis that reflective students would be higher achievers in mathematics than impulsive pupils. An achievement test was developed to measure understanding of mathematical concepts and applications, ability to solve verbal problems and recall basic facts. Data suggest that reflective students obtain better…

Basic and applied research related to the technology of space energy conversion systems, 1982 - 1983

NASA Technical Reports Server (NTRS)

Hertzberg, A.

1983-01-01

Topics on solar energy conversion concepts and applications are discussed. An overview of the current status and future utilization of radiation receivers for electrical energy generation, liquid droplet radiation systems, and liquid droplet heat exchangers is presented.

APPLICATION OF GENOMIC AND PROTEOMIC INDICATORS TO CHARACTERIZE EXPOSURE OF AQUATIC ORGANISMS TO ENVIRONMENTAL CONTAMINANTS

EPA Science Inventory

Advances in molecular biological methods are continually being brought to bear on human health research, from a basic understanding of systems biology to identification of toxicity pathways for environmental stressors and to correlations of molecular indicators with physiological...

Basic and Applied Algal Life Support System Research on Board the Deep Space Gateway

NASA Astrophysics Data System (ADS)

Niederwieser, T.; Zea, L.; Anthony, J.; Stodieck, L.

2018-02-01

We study the effect of long-term preservation methods on DNA damage of algal cultures for BLSS applications. In a secondary step, the Deep Space Gateway serves as a technology demonstration platform for algal photobioreactors in intermittently occupied habitats.

Federal Aviation Administration Small Business Innovation Research 5- Year Project Summaries

DTIC Science & Technology

1990-02-01

Completed Project: The project’s two primary objectives were to further develop the technology base for the Slaved Tandem Freewing (STF) Airplance and...margins than conventional airplances , and can meet all applicable airworthiness requirements. Adaitionally, basic design parameters were developed

Composition for Critical Thinking: A Course Description.

ERIC Educational Resources Information Center

Lazere, Donald

Intended for college or secondary school teachers of courses beyond the basic level in freshman English and composition, this course description treats components of composition for critical thinking, including semantics, tone, logic, and argumentation, and their application to writing critical, argumentative, and research papers. The introduction…

Nanotechnology and bone healing.

PubMed

Harvey, Edward J; Henderson, Janet E; Vengallatore, Srikar T

2010-03-01

Nanotechnology and its attendant techniques have yet to make a significant impact on the science of bone healing. However, the potential benefits are immediately obvious with the result that hundreds of researchers and firms are performing the basic research needed to mature this nascent, yet soon to be fruitful niche. Together with genomics and proteomics, and combined with tissue engineering, this is the new face of orthopaedic technology. The concepts that orthopaedic surgeons recognize are fabrication processes that have resulted in porous implant substrates as bone defect augmentation and medication-carrier devices. However, there are dozens of applications in orthopaedic traumatology and bone healing for nanometer-sized entities, structures, surfaces, and devices with characteristic lengths ranging from 10s of nanometers to a few micrometers. Examples include scaffolds, delivery mechanisms, controlled modification of surface topography and composition, and biomicroelectromechanical systems. We review the basic science, clinical implications, and early applications of the nanotechnology revolution and emphasize the rich possibilities that exist at the crossover region between micro- and nanotechnology for developing new treatments for bone healing.

XML, Ontologies, and Their Clinical Applications.

PubMed

Yu, Chunjiang; Shen, Bairong

2016-01-01

The development of information technology has resulted in its penetration into every area of clinical research. Various clinical systems have been developed, which produce increasing volumes of clinical data. However, saving, exchanging, querying, and exploiting these data are challenging issues. The development of Extensible Markup Language (XML) has allowed the generation of flexible information formats to facilitate the electronic sharing of structured data via networks, and it has been used widely for clinical data processing. In particular, XML is very useful in the fields of data standardization, data exchange, and data integration. Moreover, ontologies have been attracting increased attention in various clinical fields in recent years. An ontology is the basic level of a knowledge representation scheme, and various ontology repositories have been developed, such as Gene Ontology and BioPortal. The creation of these standardized repositories greatly facilitates clinical research in related fields. In this chapter, we discuss the basic concepts of XML and ontologies, as well as their clinical applications.

From the basics to application of cell therapy, a steppingstone to the conquest of neurodegeneration: a meeting report.

PubMed

Park, Dong-Hyuk; Eve, David J; Borlongan, Cesario V; Klasko, Stephen K; Cruz, L Eduardo; Sanberg, Paul R

2009-02-01

The annual meeting of the American Society for Neural Therapy and Repair (ASNTR) showcases the latest research trends in neurodegenerative disease and the related medical regenerative science. The 2008 ASNTR meeting covered a variety of different topics ranging from basic research to exploration of currently unknown pathogenesis and mechanisms for specific neurodegenerative disease such as Parkinson's disease, Alzheimer's disease, or stroke. This included studies to characterize stem cells, such as neural stem cells, embryonic stem cells, bone marrow mesenchymal stem cells, and human umbilical cord blood cells, for transplantation and the conditions necessary to maximize the efficacy of endogenous and exogenous stem cells, such as isolation, purification, differentiation, and migration. Moreover, a number of studies looked at methods for more advanced application of transplantation of cells or specific factors, through tissue engineering or manipulation beyond simple injection. Finally, well-known or previously un-known dietary supplementation or pharmacological materials that can affect the nervous system positively or negatively, were also important topics.

Access Based Cost Estimation for Beddown Analysis

DTIC Science & Technology

2006-03-23

logic. This research expands upon the existing research by using Visual Basic for Applications ( VBA ) to further customize and streamline the...methods with the use of VBA . Calculations are completed in either underlying Form VBA code or through global modules accessible throughout the...query and SQL referencing. Attempts were made where possible to align data structures with possible external sources to minimize import errors and

Study of airborne science experiment management concepts for application to space shuttle, volume 2

NASA Technical Reports Server (NTRS)

Mulholland, D. R.; Reller, J. O., Jr.; Neel, C. B.; Haughney, L. C.

1973-01-01

Airborne research management and shuttle sortie planning at the Ames Research Center are reported. Topics discussed include: basic criteria and procedures for the formulation and approval of airborne missions; ASO management structure and procedures; experiment design, development, and testing aircraft characteristics and experiment interfaces; information handling for airborne science missions; mission documentation requirements; and airborne science methods and shuttle sortie planning.

Indo-US Workshop on Nanotechnology: Applications and Implications, November 10-12, 2009

DTIC Science & Technology

2009-11-12

the copyright holder. 14. ABSTRACT This is the proceedings of a conference basic and applied research on nanotechnology with a focus on the ...wish the workshop a grand success. — V ( K.ROSAIAH ) Dr.Paramjit Grover, Organising Secretary, Indo-US Workshop on Nanotechnology: Applications...environmental impact of Nanomaterials and their potential effects on global economics. There is an urgent need for a debate among the concerned

Design of wireless communication system for environmental monitoring

NASA Astrophysics Data System (ADS)

Jiang, Li; Zhang, Xiaoyang; Sun, Zhixiang; Tian, Youcheng; Wang, Juan; Guo, Jianghua

2017-05-01

This paper introduces the basic principle and advantages of GPRS data transmission, and discusses in detail about the hardware structure of the GPRS module, the connection mode and the research process of GPRS application in the device. The feasibility and superiority of GPRS data transmission in wireless water quality monitoring device have been tested and proved, which provides great convenience for water quality monitoring, and has good application prospect.

Conference Comments by the Editors

NASA Astrophysics Data System (ADS)

Novotny, Rainer; Nikl, Martin; Williams, Richard T.; Auffray, Etiennette; Dorenbos, Pieter; Dujardin, Christophe; era, Miroslav Ku c.˘; Mihóková, Eva; Wojtowicz, Andrzej J.

2012-10-01

The SCINT series of conferences on Inorganic Scintillators and their Applications has provided, beginning in 1992, a regular platform for researchers from all over the world working in this field. This conference merges the aspects of basic science with application-related issues in the field of inorganic scintillators and phosphors and provides unique opportunities for both scientists and engineers to exchange their new results and ideas. Previous SCINT conferences were held first in Chamonix in 1992 and then in San Francisco, Delft, Shanghai, Moscow, Chamonix, Valencia, Alushta, Winston- Salem, and Jeju Island in Korea in 2009. The most recent, the 11th International Conference on Inorganic Scintillators and their Applications (SCINT 2011), was held at the Science Campus of Justus Liebig University, Giessen, Germany, September 11¿16, 2011. There were a total 187 scientific contributions, 82 oral presentations, 19 invited talks, and 105 poster exhibitions presented by 235 participants from 24 different countries. For the first time, a pre-conference tutorial was organized, which covered the basic physics of scintillation mechanisms as well as the wide field of applications. The purpose was mainly to educate students and newcomers in the field. This special issue of the IEEE TRANSACTIONS ON NUCLEAR SCIENCE comprises the refereed proceedings of SCINT 2011, containing 61 papers on the research presentations.

NASA Glenn Research Center Electrochemistry Branch Battery Overview

NASA Technical Reports Server (NTRS)

Manzo, Michelle A.

2010-01-01

This presentation covers an overview of NASA Glenn s history and heritage in the development of electrochemical systems for aerospace applications. Specific areas of focus are Li-ion batteries and their development for future Exploration missions. Current component development efforts for high energy and ultra high energy Li-ion batteries are addressed. Electrochemical systems are critical to the success of Exploration, Science and Space Operations missions. NASA Glenn has a long, successful heritage with batteries and fuel cells for aerospace applications. GRC Battery capabilities and expertise span basic research through flight hardware development and implementation. There is a great deal of synergy between energy storage system needs for aerospace and terrestrial applications.

Biophysics at the Boundaries: The Next Problem Sets

NASA Astrophysics Data System (ADS)

Skolnick, Malcolm

2009-03-01

The interface between physics and biology is one of the fastest growing subfields of physics. As knowledge of such topics as cellular processes and complex ecological systems advances, researchers have found that progress in understanding these and other systems requires application of more quantitative approaches. Today, there is a growing demand for quantitative and computational skills in biological research and the commercialization of that research. The fragmented teaching of science in our universities still leaves biology outside the quantitative and mathematical culture that is the foundation of physics. This is particularly inopportune at a time when the needs for quantitative thinking about biological systems are exploding. More physicists should be encouraged to become active in research and development in the growing application fields of biophysics including molecular genetics, biomedical imaging, tissue generation and regeneration, drug development, prosthetics, neural and brain function, kinetics of nonequilibrium open biological systems, metabolic networks, biological transport processes, large-scale biochemical networks and stochastic processes in biochemical systems to name a few. In addition to moving into basic research in these areas, there is increasing opportunity for physicists in industry beginning with entrepreneurial roles in taking research results out of the laboratory and in the industries who perfect and market the inventions and developments that physicists produce. In this talk we will identify and discuss emerging opportunities for physicists in biophysical and biotechnological pursuits ranging from basic research through development of applications and commercialization of results. This will include discussion of the roles of physicists in non-traditional areas apart from academia such as patent law, financial analysis and regulatory science and the problem sets assigned in education and training that will enable future biophysicists to fill these roles.

Experiments in autonomous robotics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hamel, W.R.

1987-01-01

The Center for Engineering Systems Advanced Research (CESAR) is performing basic research in autonomous robotics for energy-related applications in hazardous environments. The CESAR research agenda includes a strong experimental component to assure practical evaluation of new concepts and theories. An evolutionary sequence of mobile research robots has been planned to support research in robot navigation, world sensing, and object manipulation. A number of experiments have been performed in studying robot navigation and path planning with planar sonar sensing. Future experiments will address more complex tasks involving three-dimensional sensing, dexterous manipulation, and human-scale operations.

A Review of Particle Swarm Optimization

NASA Astrophysics Data System (ADS)

Jain, N. K.; Nangia, Uma; Jain, Jyoti

2018-03-01

This paper presents an overview of the research progress in Particle Swarm Optimization (PSO) during 1995-2017. Fifty two papers have been reviewed. They have been categorized into nine categories based on various aspects. This technique has attracted many researchers because of its simplicity which led to many improvements and modifications of the basic PSO. Some researchers carried out the hybridization of PSO with other evolutionary techniques. This paper discusses the progress of PSO, its improvements, modifications and applications.

Wide Band-Gap Semiconductors. 1991 Materials Research Society Symposium Proceedings

DTIC Science & Technology

1992-09-01

attention of many research groups bccause the instrumental simplicity and high growth rate (1,2). One of the basic problems with this technique, other than...solution with group 1a element as a dopant under controlled Zn vapor pressure. p-n junction diodes are also prepared by the Ga diffusion from Zn solution...stoichiometric composition catl be controlled by the application of the vapor pressure. Mat. Res. Soc. Symp. Proc. Vol. 242. 1992 Materials Research Society 180

ESN (European Science Notes) Information Bulletin Reports on Current European/Middle Eastern Science

DTIC Science & Technology

1988-10-01

about 35 institutes. tion method for technical alcohol, a modified upflow The quality of research carried out at the various fermenter was constructed in...developed for research with this fermenter whereby suc- application. It is beyond the scope of this report to de- rose, glucose, fructose, and...that lactobacilli in Food Research. Among the important aspects of the di- foods such as yogurt , cheese, sausage, and sauerkraut vision’s work on basic

An ontologically founded architecture for information systems in clinical and epidemiological research.

PubMed

Uciteli, Alexandr; Groß, Silvia; Kireyev, Sergej; Herre, Heinrich

2011-08-09

This paper presents an ontologically founded basic architecture for information systems, which are intended to capture, represent, and maintain metadata for various domains of clinical and epidemiological research. Clinical trials exhibit an important basis for clinical research, and the accurate specification of metadata and their documentation and application in clinical and epidemiological study projects represents a significant expense in the project preparation and has a relevant impact on the value and quality of these studies.An ontological foundation of an information system provides a semantic framework for the precise specification of those entities which are presented in this system. This semantic framework should be grounded, according to our approach, on a suitable top-level ontology. Such an ontological foundation leads to a deeper understanding of the entities of the domain under consideration, and provides a common unifying semantic basis, which supports the integration of data and the interoperability between different information systems.The intended information systems will be applied to the field of clinical and epidemiological research and will provide, depending on the application context, a variety of functionalities. In the present paper, we focus on a basic architecture which might be common to all such information systems. The research, set forth in this paper, is included in a broader framework of clinical research and continues the work of the IMISE on these topics.

Hydrogen Flame Imaging System Soars to New, Different Heights

NASA Technical Reports Server (NTRS)

2002-01-01

When Judy and Dave Duncan of Auburn, Calif.-based Duncan Technologies Inc. (DTI) developed their color hydrogen flame imaging system in the early 1990's, their market prospects were limited. 'We talked about commercializing the technology in the hydrogen community, but we also looked at commercialization on a much broader aspect. While there were some hydrogen applications, the market was not large enough to suppport an entire company; also, safety issues were a concern,' said Judy Duncan, owner and CEO of Duncan Technologies. Using the basic technology developed under the Small Business Innovation Research Program (SBIR); DTI conducted market research, identified other applications, formulated a plan for next generation development, and implemented a far-reaching marketing strategy. 'We took that technology; reinvested our own funds and energy into a second-generation design on the overall camera electronics and deployed that basic technology intially in a series of what we call multi-spectral cameras; cameras that could image in both the visible range and the infrared,' explains Duncan. 'The SBIR program allowed us to develop the technology to do a 3CCD camera, which very few compaines in the world do, particularly not small companies. The fact that we designed our own prism and specked the coding as we had for the hydrogen application, we were able to create a custom spectral configuration which could support varying types of research and applications.' As a result, Duncan Technologies Inc. of Auburn, Ca., has achieved a milestone $ 1 million in sales.

Obama address touches on research, energy, and environmental issues

NASA Astrophysics Data System (ADS)

Showstack, Randy

2012-02-01

President Barack Obama's State of the Union message, delivered on 24 January, touched on the need for basic research, energy production, support for clean energy, and environmental protection, but it included just one passing reference to climate change. In addition, the speech made no note of the Administration's recent denial of a controversial application for the Keystone XL pipeline to transport crude oil from Canada to the United States and made just an elliptical reference regarding the bankrupt Solyndra Corporation, which the administration had touted as a clean energy company. Innovation "demands basic research," Obama said, adding that Congress should not "gut these investments in our budget." Noting that one promise for innovation is American-made energy, Obama said he is directing the administration to "open more than 75% of our potential offshore oil and gas resources."

EDITORIAL: Cluster issue on microplasmas

NASA Astrophysics Data System (ADS)

Chao, Chih C.; Liao, Jiunn-Der; Chang, Juu-En

2008-10-01

Ever since the first Workshop on Microplasmas, held in Japan in 2003, plasma scientists and engineers worldwide have been meeting approximately every 18 months to exchange and discuss the results of scientific research and technical applications of this unique type of plasma. Microplasmas are generally described as stable plasmas confined to spatial dimensions below about 1 mm that can be operated at pressures up to and exceeding atmospheric pressure. By their nature, this presents a wide range of opportunities and many advantages in practical applications, just a few examples being low energy consumption, small size, flexibility of use and ease of assembly into a user-friendly package. Nevertheless, there still remain several unanswered basic science questions and a largely untapped potential for environmental, biomedical and industrial applications. The fourth International Workshop on Microplasmas, held during 28-31 October 2007 in Tainan, Taiwan, continued the trend of previous Workshops with an orientation towards industrial and environmental applications. Many high-quality papers on microplasmas and microdischarges were presented and selected full papers were submitted to Journal of Physics D: Applied Physics for assessment by the editors and reviewers in accordance with the usual standards of quality and novelty. This Cluster Issue contains twelve accepted papers, covering four categories: fundamentals and basics, and environmental, biomedical and industrial applications. Fundamentals and basics includes coverage of the physics and microstructure of electrode discharge (Yu A Lebedev et al), the characteristics of low current discharge (Z Lj Petrović et al), plasma ignition (R Gesche et al), novel optical diagnostics (Schulz-von der Gathen et al), plasma generation and micronozzle flow (T Takahashi et al) and the relation between RF-power and atomic oxygen density distribution (N Knake et al). Environmental applications are represented by vapour-phase discharges in liquid capillaries (P Bruggeman et al) and biomedical applications by antibacterial treatment (K D Weltmann et al). Industrial applications include on-chip microplasma reactors (A Agiral et al), miniaturized atmospheric pressure plasma jets (J Schäfer et al and A V Pipa et al) and microplasma stamps (N Lucas et al). All of these represent important findings and advances in microplasma research and applications. We would like to thank the Publisher of the journal, Sarah Quin, and the editorial staff for their support and management of the publication. It is sincerely hoped that the contents of this Cluster Issue will promote understanding of microplasmas and microdischarges, and inspire further research towards industrial applications.

An extensible and successful method of identifying collaborators for National Library of Medicine informationist projects.

PubMed

Williams, Jeff D; Rambo, Neil H

2015-07-01

The New York University (NYU) Health Sciences Library used a new method to arrange in-depth discussions with basic science researchers. The objective was to identify collaborators for a new National Library of Medicine administrative supplement. The research took place at the NYU Health Sciences Library. Using the National Institutes of Health (NIH) RePORTER, forty-four researchers were identified and later contacted through individualized emails. Nine researchers responded to the email followed by six in-person or phone discussions. At the conclusion of this process, two researchers submitted applications for supplemental funding, and both of these applications were successful. This method confirmed these users could benefit from the skills and knowledge of health sciences librarians, but they are largely unaware of this.

[Implementation of the International Health Regulations in Cuba: evaluation of basic capacities of the health sector in selected provinces].

PubMed

Gala, Ángela; Toledo, María Eugenia; Arias, Yanisnubia; Díaz González, Manuel; Alvarez Valdez, Angel Manuel; Estévez, Gonzalo; Abreu, Rolando Miyar; Flores, Gustavo Kourí

2012-09-01

Obtain baseline information on the status of the basic capacities of the health sector at the local, municipal, and provincial levels in order to facilitate identification of priorities and guide public policies that aim to comply with the requirements and capacities established in Annex 1A of the International Health Regulations 2005 (IHR-2005). A descriptive cross-sectional study was conducted by application of an instrument of evaluation of basic capacities referring to legal and institutional autonomy, the surveillance and research process, and the response to health emergencies in 36 entities involved in international sanitary control at the local, municipal, and provincial levels in the provinces of Havana, Cienfuegos, and Santiago de Cuba. The polyclinics and provincial centers of health and epidemiology in the three provinces had more than 75% of the basic capacities required. Twelve out of 36 units had implemented 50% of the legal and institutional framework. There was variable availability of routine surveillance and research, whereas the entities in Havana had more than 40% of the basic capacities in the area of events response. The provinces evaluated have integrated the basic capacities that will allow implementation of IHR-2005 within the period established by the World Health Organization. It is necessary to develop and establish effective action plans to consolidate surveillance as an essential activity of national and international security in terms of public health.

Application of communications satellites to educational development. [technology utilization/information systems - bibliographies

NASA Technical Reports Server (NTRS)

Morgan, R. P.

1975-01-01

A summary of research is presented. The broad objectives of this interdisciplinary research effort were: (1) to assess the role of satellite communications as a means of improving education in the United States, as well as in less-developed areas of the world; (2) to generate basic knowledge which will aid in making rational decisions about satellite application in the field of education in the years ahead; (3) to devise systems and strategies for improving education; and (4) to educate individuals who will be knowledgeable about aspects of satellite communications policy which transcend any single discipline.

Applications of patient-specific induced pluripotent stem cells; focused on disease modeling, drug screening and therapeutic potentials for liver disease.

PubMed

Chun, Yong Soon; Chaudhari, Pooja; Jang, Yoon-Young

2010-12-14

The recent advances in the induced pluripotent stem cell (iPSC) research have significantly changed our perspectives on regenerative medicine by providing researchers with a unique tool to derive disease-specific stem cells for study. In this review, we describe the human iPSC generation from developmentally diverse origins (i.e. endoderm-, mesoderm-, and ectoderm- tissue derived human iPSCs) and multistage hepatic differentiation protocols, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening/drug discovery, gene therapy and cell replacement therapy.

3D Bio-Printing Review

NASA Astrophysics Data System (ADS)

Du, Xianbin

2018-01-01

Ultimate goal of tissue engineering is to replace pathological or necrotic body tissue or organ by artificial tissue or organ and tissue engineering is a very promising research field. 3D bio-printing is a kind of emerging technologies and a branch of tissue engineering. It has made significant progress in the past decade. 3D bio-printing can realize tissue and organ construction in vitro and has wide application in basic research and pharmacy. This paper is to make an analysis and review on 3D bio-printing from the perspectives of bioink, printing technology and technology application.

Research and technology

NASA Technical Reports Server (NTRS)

1984-01-01

The role of the Langley Research Center is to engage in the basic and applied research necessary for the advancement of aeronautics and space flight, to enerate new and advanced concepts for the accomplishment of related national goals, and to provide research advice, technological support, and assistance to other NASA installations, other government agencies, and industry. Highlights of the major accomplishments and applications made during the past year are described. The highlights illustrate both the broad range of the research and technology activities at the Langley Research Center and the contributions of this work toward maintaining United States leadership in aeronautics and space research.

76 FR 21387 - National Institute of Environmental Health Sciences; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-15

... applications. Place: Hilton Garden Inn Durham Southpoint, 7007 Fayetteville Road, Durham, NC 27713. Contact....142, NIEHS Hazardous Waste Worker Health and Safety Training; 93.143, NIEHS Superfund Hazardous Substances--Basic Research and Education; 93.894, Resources and Manpower Development in the Environmental...

78 FR 26793 - National Institute of Environmental Health Sciences; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-08

... evaluate grant applications. Place: Hilton Garden Inn Durham Southpoint Hotel, 7007 Fayetteville Road...--Health Risks from Environmental Exposures; 93.142, NIEHS Hazardous Waste Worker Health and Safety Training; 93.143, NIEHS Superfund Hazardous Substances--Basic Research and Education; 93.894, Resources and...

Computer Mediated Communication: Online Instruction and Interactivity.

ERIC Educational Resources Information Center

Lavooy, Maria J.; Newlin, Michael H.

2003-01-01

Explores the different forms and potential applications of computer mediated communication (CMC) for Web-based and Web-enhanced courses. Based on their experiences with three different Web courses (Research Methods in Psychology, Statistical Methods in Psychology, and Basic Learning Processes) taught repeatedly over the last five years, the…

Demasking Wall Street's Influence on Stock Prices.

ERIC Educational Resources Information Center

Saban, Kenneth A.

1987-01-01

Presents an in-depth review of the market research approach of a comprehensive financial community. Discusses the applied corporate findings when author was Vice President, Corporate Communications, Midland-Ross Corporation. Suggests that the basic concept is applicable to any publicly traded company whose senior management desires a more…

Chem I Supplement: Liquid Crystals--The Chameleon Chemicals.

ERIC Educational Resources Information Center

Brown, Glenn H.

1983-01-01

Presents information relevant to everyday life so as to stimulate student interest in the properties of the two basic types of liquid crystals: thermotropic and lyotropic. Describes the applications of liquid crystals to electronics, biomedicine, and polymer science and appraises the future of liquid crystal research. (JM)

75 FR 64744 - Manufacturer of Controlled Substances; Notice of Application

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-20

... manufacturer of the basic classes of controlled substances listed in schedule I: Drug Schedule Marihuana (7360) I Tetrahydrocannabinols (7370) I The company plans to manufacture small quantities of marihuana derivatives for research purposes. In reference to drug code 7360 (Marihuana), the company plans to bulk...

Observing Ben Wyckoff: From Basic Research to Programmed Instruction and Social Issues

PubMed Central

Escobar, Rogelio; Lattal, Kennon A

2011-01-01

L. Benjamin Wyckoff's seminal contributions to both psychological theory and application are the subject of this review. Wyckoff started his academic career as a graduate student at Indiana University, where he developed the observing-response procedure under the guidance of B. F. Skinner and C. J. Burke. At the University of Wisconsin–Madison, Wyckoff refined his mathematical theory of secondary reinforcement. This theory was the impetus for his creation of an electronic simulation of a rat running a T maze, one of the first “computer models” of learning. Wyckoff next went to Emory University, leaving there to help create two of the most successful companies dedicated to the advancement of programmed instruction and teaching machines: Teaching Machines, Inc. and the Human Development Institute. Wyckoff's involvement in these companies epitomizes the application of basic behavior-analytic principles in the development of technology to improve education and human relationships. The emergent picture of Wyckoff is that of a man who, through his research, professional work in educational applications of behavioral principles, and active involvement in the civil rights movement of the 1960s, was strongly committed to applying behavioral science to positively influence human behavior change. PMID:22532737

Mobile health use in low- and high-income countries: an overview of the peer-reviewed literature

PubMed Central

Bastawrous, Andrew; Armstrong, Matthew J

2013-01-01

The evolution of mobile phone technology has introduced new possibilities to the field of medicine. Combining technological advances with medical expertise has led to the use of mobile phones in all healthcare areas including diagnostics, telemedicine, research, reference libraries and interventions. This article provides an overview of the peer-reviewed literature, published between 1 August 2006 and 1 August 2011, for the application of mobile/cell phones (from basic text-messaging systems to smartphones) in healthcare in both resource-poor and high-income countries. Smartphone use is paving the way in high-income countries, while basic text-messaging systems of standard mobile phones are proving to be of value in low- and middle-income countries. Ranging from infection outbreak reporting, anti-HIV therapy adherence to gait analysis, resuscitation training and radiological imaging, the current uses and future possibilities of mobile phone technology in healthcare are endless. Multiple mobile phone based applications are available for healthcare workers and healthcare consumers; however, the absolute majority lack an evidence base. Therefore, more rigorous research is required to ensure that healthcare is not flooded with non-evidence based applications and is maximized for patient benefit. PMID:23564897

From bench to bedside and to health policies (and back): ethics in translational research.

PubMed

Petrini, Carlo

2014-01-01

The medical aim of translational research is to smooth the transition of discoveries made through basic research from the laboratory bench to their diagnostic or therapeutic applications for patients. These applications may be extended to current clinical practice and to health policies. The converse is also important: health policies should provide a point of departure when identifying research priorities. Translational research poses the same ethical problems as trials with human subjects - albeit in different ways. One of the more significant problems is the risk for participants in trials: it is thus necessary to ensure that the risks to which these subjects are exposed are not out of proportion to the expected benefits. Translational research does not require new ethical principles, but existing biomedical principles need to be adjusted to the specific context. The well-being of participants should always be the primary objective; these persons should never be considered as means for the advancement of knowledge or for the improvement of applications.

CFD code evaluation for internal flow modeling

NASA Technical Reports Server (NTRS)

Chung, T. J.

1990-01-01

Research on the computational fluid dynamics (CFD) code evaluation with emphasis on supercomputing in reacting flows is discussed. Advantages of unstructured grids, multigrids, adaptive methods, improved flow solvers, vector processing, parallel processing, and reduction of memory requirements are discussed. As examples, researchers include applications of supercomputing to reacting flow Navier-Stokes equations including shock waves and turbulence and combustion instability problems associated with solid and liquid propellants. Evaluation of codes developed by other organizations are not included. Instead, the basic criteria for accuracy and efficiency have been established, and some applications on rocket combustion have been made. Research toward an ultimate goal, the most accurate and efficient CFD code, is in progress and will continue for years to come.

History and trends of bioactive glass-ceramics.

PubMed

Montazerian, Maziar; Dutra Zanotto, Edgar

2016-05-01

The interest around bioactive glass-ceramics (GCs) has grown significantly over the last two decades due to their appropriate biochemical and mechanical properties. The intense research effort in this field has led to some new commercial products for biomedical applications. This review article begins with the basic concepts of GC processing and development via controlled heat treatments of monolithic pieces or sinter-crystallization of powdered glasses. We then go on to describe the processing, properties, and applications of some commercial bioactive GCs and discuss selected valuable reported researches on several promising types of bioactive GCs. The article finishes with a section on open relevant research directions for bioactive GC development. © 2016 Wiley Periodicals, Inc.

CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells

PubMed Central

Kim, Eun Ji; Kang, Ki Ho; Ju, Ji Hyeon

2017-01-01

Recent advances in genome editing with programmable nucleases have opened up new avenues for multiple applications, from basic research to clinical therapy. The ease of use of the technology—and particularly clustered regularly interspaced short palindromic repeats (CRISPR)—will allow us to improve our understanding of genomic variation in disease processes via cellular and animal models. Here, we highlight the progress made in correcting gene mutations in monogenic hereditary disorders and discuss various CRISPR-associated applications, such as cancer research, synthetic biology, and gene therapy using induced pluripotent stem cells. The challenges, ethical issues, and future prospects of CRISPR-based systems for human research are also discussed. PMID:28049282

Research on Service Platform of Internet of Things for Smart City

NASA Astrophysics Data System (ADS)

Wang, W.; He, Z.; Huang, D.; Zhang, X.

2014-04-01

The application of Internet of Things in surveying and mapping industry basically is at the exploration stage, has not formed a unified standard. Chongqing Institute of Surveying and Mapping (CQISM) launched the research p roject "Research on the Technology of Internet of Things for Smart City". The project focuses on the key technologies of information transmission and exchange on the Internet of Things platform. The data standards of Internet of Things are designed. The real-time acquisition, mass storage and distributed data service of mass sensors are realized. On this basis, CQISM deploys the prototype platform of Internet of Things. The simulation application in Connected Car proves that the platform design is scientific and practical.

CRISPR-Cas9: a promising tool for gene editing on induced pluripotent stem cells.

PubMed

Kim, Eun Ji; Kang, Ki Ho; Ju, Ji Hyeon

2017-01-01

Recent advances in genome editing with programmable nucleases have opened up new avenues for multiple applications, from basic research to clinical therapy. The ease of use of the technology-and particularly clustered regularly interspaced short palindromic repeats (CRISPR)-will allow us to improve our understanding of genomic variation in disease processes via cellular and animal models. Here, we highlight the progress made in correcting gene mutations in monogenic hereditary disorders and discuss various CRISPR-associated applications, such as cancer research, synthetic biology, and gene therapy using induced pluripotent stem cells. The challenges, ethical issues, and future prospects of CRISPR-based systems for human research are also discussed.

Concepts for the clinical use of stem cells in equine medicine

PubMed Central

Koch, Thomas G.; Berg, Lise C.; Betts, Dean H.

2008-01-01

Stem cells from various tissues hold great promise for their therapeutic use in horses, but so far efficacy or proof-of-principle has not been established. The basic characteristics and properties of various equine stem cells remain largely unknown, despite their increasingly widespread experimental and empirical commercial use. A better understanding of equine stem cell biology and concepts is needed in order to develop and evaluate rational clinical applications in the horse. Controlled, well-designed studies of the basic biologic characteristics and properties of these cells are needed to move this new equine research field forward. Stem cell research in the horse has exciting equine specific and comparative perspectives that will most likely benefit the health of horses and, potentially, humans. PMID:19119371

32 CFR 272.3 - Definition of basic research.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Definition of basic research. 272.3 Section 272...) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.3 Definition of basic research. Basic research is systematic study directed toward greater knowledge or understanding of...

32 CFR 272.3 - Definition of basic research.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Definition of basic research. 272.3 Section 272...) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.3 Definition of basic research. Basic research is systematic study directed toward greater knowledge or understanding of...

Academic research opportunities at the National Geospatial-Intelligence Agency(NGA)

NASA Astrophysics Data System (ADS)

Loomer, Scott A.

2006-05-01

The vision of the National Geospatial-Intelligence Agency (NGA) is to "Know the Earth...Show the Way." To achieve this vision, the NGA provides geospatial intelligence in all its forms and from whatever source-imagery, imagery intelligence, and geospatial data and information-to ensure the knowledge foundation for planning, decision, and action. Academia plays a key role in the NGA research and development program through the NGA Academic Research Program. This multi-disciplinary program of basic research in geospatial intelligence topics provides grants and fellowships to the leading investigators, research universities, and colleges of the nation. This research provides the fundamental science support to NGA's applied and advanced research programs. The major components of the NGA Academic Research Program are: *NGA University Research Initiatives (NURI): Three-year basic research grants awarded competitively to the best investigators across the US academic community. Topics are selected to provide the scientific basis for advanced and applied research in NGA core disciplines. *Historically Black College and University - Minority Institution Research Initiatives (HBCU-MI): Two-year basic research grants awarded competitively to the best investigators at Historically Black Colleges and Universities, and Minority Institutions across the US academic community. *Intelligence Community Post-Doctoral Research Fellowships: Fellowships providing access to advanced research in science and technology applicable to the intelligence community's mission. The program provides a pool of researchers to support future intelligence community needs and develops long-term relationships with researchers as they move into career positions. This paper provides information about the NGA Academic Research Program, the projects it supports and how researchers and institutions can apply for grants under the program. In addition, other opportunities for academia to engage with NGA through training programs and recruitment are discussed.

Physics through the 1990s: Scientific interfaces and technological applications

NASA Technical Reports Server (NTRS)

1986-01-01

The volume examines the scientific interfaces and technological applications of physics. Twelve areas are dealt with: biological physics-biophysics, the brain, and theoretical biology; the physics-chemistry interface-instrumentation, surfaces, neutron and synchrotron radiation, polymers, organic electronic materials; materials science; geophysics-tectonics, the atmosphere and oceans, planets, drilling and seismic exploration, and remote sensing; computational physics-complex systems and applications in basic research; mathematics-field theory and chaos; microelectronics-integrated circuits, miniaturization, future trends; optical information technologies-fiber optics and photonics; instrumentation; physics applications to energy needs and the environment; national security-devices, weapons, and arms control; medical physics-radiology, ultrasonics, MNR, and photonics. An executive summary and many chapters contain recommendations regarding funding, education, industry participation, small-group university research and large facility programs, government agency programs, and computer database needs.

Infrastructure dynamics: A selected bibliography

NASA Technical Reports Server (NTRS)

Dajani, J. S.; Bencosme, A. J.

1978-01-01

The term infrastructure is used to denote the set of life support and public service systems which is necessary for the development of growth of human settlements. Included are some basic references in the field of dynamic simulation, as well as a number of relevant applications in the area of infrastructure planning. The intent is to enable the student or researcher to quickly identify such applications to the extent necessary for initiating further work in the field.

77 FR 43849 - National Institute of Environmental Health Sciences; Notice of Closed Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-26

... applications. Place: Hilton Garden Inn Durham Southpoint, 7007 Fayetteville Road, Durham, NC 27713. Contact... Waste Worker Health and Safety Training; 93.143, NIEHS Superfund Hazardous Substances--Basic Research and Education; 93.894, Resources and Manpower Development in the Environmental Health Sciences; 93.113...

Introduction to the Application of Web-Based Surveys.

ERIC Educational Resources Information Center

Timmerman, Annemarie

This paper discusses some basic assumptions and issues concerning web-based surveys. Discussion includes: assumptions regarding cost and ease of use; disadvantages of web-based surveys, concerning the inability to compensate for four common errors of survey research: coverage error, sampling error, measurement error and nonresponse error; and…

The Command and Control Reference Model for Modeling, Simulations, and Technology Applications

DTIC Science & Technology

1994-01-20

NUMBER Basic Research Group (BRG), Technical Panel for C3 (TPC3) Joint Directors of Laboratories (JDL) JDL TPC3 BRG NRaD, San Diego , CA 92152; RADC...wind, ionization, pressure, pollution, ... mesofeature (weather, man-made) cloud, storm, fog, smog, dust, fire, jet stream, smoke, aurora borealis

Latin American space activities based on different infrastructures

NASA Astrophysics Data System (ADS)

Gall, Ruth

The paper deals with recent basic space research and space applications in several Latin-American countries. It links space activities with national scientific and institutional infrastructures and stresses the importance of interdisciplinary space programs, that can play a major role in the developing countries achievement of self reliance in space matters.

Bringing Science Research into Secondary Schools

ERIC Educational Resources Information Center

Allwood, Dan A.; Dean, Julian; Bryan, Matthew T.; Baker, Alan

2009-01-01

Finite element modelling software has been used to allow secondary school students to study nanoscale magnetic materials for hard drive recording applications. The students were introduced to the basic concepts of finite element modelling using a freely available internet game before modelling the magnetization reversal of single magnetic grains.…

Photonic Diagnostic Technique For Thin Photoactive Films

NASA Technical Reports Server (NTRS)

Thakoor, Sarita

1996-01-01

Photonic diagnostic technique developed for use in noninvasive, rapid evaluation of thin paraelectric/ferroelectric films. Method proves useful in basic research, on-line monitoring for quality control at any stage of fabrication, and development of novel optoelectronic systems. Used to predict imprint-prone memory cells, and to study time evolution of defects in ferroelectric memories during processing. Plays vital role in enabling high-density ferroelectric memory manufacturing. One potential application lies in use of photoresponse for nondestructive readout of polarization memory states in high-density, high-speed memory devices. In another application, extension of basic concept of method makes possible to develop specially tailored ferrocapacitor to act as programmable detector, wherein remanent polarization used to modulate photoresponse. Large arrays of such detectors useful in optoelectronic processing, computing, and communication.

Conceptual design project: Accelerator complex for nuclear physics studies and boron neutron capture therapy application at the Yerevan Physics Institute (YerPhI) Yerevan, Armenia

NASA Astrophysics Data System (ADS)

Avagyan, R. H.; Kerobyan, I. A.

2015-07-01

The final goal of the proposed project is the creation of a Complex of Accelerator Facilities at the Yerevan Physics Institute (CAF YerPhI) for nuclear physics basic researches, as well as for applied programs including boron neutron capture therapy (BNCT). The CAF will include the following facilities: Cyclotron C70, heavy material (uranium) target/ion source, mass-separator, LINAC1 (0.15-1.5 MeV/u) and LINAC2 (1.5-10 MeV/u). The delivered by C70 proton beams with energy 70 MeV will be used for investigations in the field of basic nuclear physics and with energy 30 MeV for use in applications.

Summaries of FY 1993 Engineering Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1993-09-01

This report documents the BES Engineering Research Program for fiscal year 1993; it provides a summary for each of the program projects in addition to a brief program overview. The report is intended to provide staff of Congressional committees, other executive departments, and other DOE offices with substantive program information so as to facilitate governmental overview and coordination of Federal research programs. Of equal importance, its availability facilitates communication of program information to interested research engineers and scientists. The organizational chart for the DOE Office of Energy Research (OER) on the next page delineates the six Divisions within the OERmore » Office of Basic Energy Sciences (BES). Each BES Division administers basic, mission oriented research programs in the area indicated by its title. The BES Engineering Research Program is one such program; it is administered by the Engineering and Geosciences Division of BES. In preparing this report we asked the principal investigators to submit summaries for their projects that were specifically applicable to fiscal year 1993. The summaries received have been edited if necessary.« less

Gravitational biology on the space station

NASA Technical Reports Server (NTRS)

Keefe, J. R.; Krikorian, A. D.

1983-01-01

The current status of gravitational biology is summarized, future areas of required basic research in earth-based and spaceflight projects are presented, and potential applications of gravitational biology on a space station are demonstrated. Topics covered include vertebrate reproduction, prenatal/postnatal development, a review of plant space experiments, the facilities needed for growing plants, gravimorphogenesis, thigmomorphogenesis, centrifuges, maintaining a vivarium, tissue culture, and artificial human organ generation. It is proposed that space stations carrying out these types of long-term research be called the National Space Research Facility.

Research in applied mathematics, numerical analysis, and computer science

NASA Technical Reports Server (NTRS)

1984-01-01

Research conducted at the Institute for Computer Applications in Science and Engineering (ICASE) in applied mathematics, numerical analysis, and computer science is summarized and abstracts of published reports are presented. The major categories of the ICASE research program are: (1) numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; (2) control and parameter identification; (3) computational problems in engineering and the physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and (4) computer systems and software, especially vector and parallel computers.

Institute for Sustainable Energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agrawal, Ajay

2016-03-28

Alternate fuels offer unique challenges and opportunities as energy source for power generation, vehicular transportation, and industrial applications. Institute for Sustainable Energy (ISE) at UA conducts innovative research to utilize the complex mix of domestically-produced alternate fuels to achieve low-emissions, high energy-efficiency, and fuel-flexibility. ISE also provides educational and advancement opportunities to students and researchers in the energy field. Basic research probing the physics and chemistry of alternative fuels has generated practical concepts investigated in a burner and engine test platforms.

Hermeneutic application research - finding a common understanding and consensus on care and caring.

PubMed

Koskinen, Camilla; Nyström, Lisbet

2017-03-01

To clinically and contextually implement the theoretical and factual knowledge of care and caring that has been developed in the last 30 years is seen as a great challenge in caring science research. Emphasis has been put on problem-solving research methodologies and action research in hopes of narrowing the divide between caring theory and clinical practice. Thus, the intention is now to further action research towards a hermeneutic approach and to put emphasis on hermeneutic application where theory and praxis become one through human dialogue. This article highlights hermeneutic application research as an alternative methodology within participatory-oriented research which presents a new opportunity to unite clinical practice and caring theory. The aim is to contribute to the development of the hermeneutical application research design in its epistemological, ontological and ethical perspective, by articulating and clarifying the central foundations in the application. On the basis of Gadamer's hermeneutical thinking and Levinas ethical thinking, the central foundations in the application research are ethics, creation of a hermeneutical room, dialogue and common understanding and appropriation and action. When theoretical understanding turns into praxis, knowledge also becomes activity and theory and practice become one. Application thus realises the basic idea that praxis and theory are one, and thus, theory of caring can only become evident and implemented in a clinical practice through moments when the participants find a common understanding and consensus on the knowledge of care and caring. © 2015 Nordic College of Caring Science.

Freely available compound data sets and software tools for chemoinformatics and computational medicinal chemistry applications

PubMed Central

Bajorath, Jurgen

2012-01-01

We have generated a number of  compound data sets and programs for different types of applications in pharmaceutical research. These data sets and programs were originally designed for our research projects and are made publicly available. Without consulting original literature sources, it is difficult to understand specific features of data sets and software tools, basic ideas underlying their design, and applicability domains. Currently, 30 different entries are available for download from our website. In this data article, we provide an overview of the data and tools we make available and designate the areas of research for which they should be useful. For selected data sets and methods/programs, detailed descriptions are given. This article should help interested readers to select data and tools for specific computational investigations. PMID:24358818

Stem-Cell Work Yielding New Approach to Disease: Induced Pluripotent Stem-Cell Research Soars, Spurring Dreams of Clinical Applications.

PubMed

Mertz, Leslie

2016-01-01

Interest in stem cells escalated in 2006 when scientists figured out how to reprogram some specialized adult cells to assume a stem-cell-like state. Called induced pluripotent stem cells (iPSCs), these cells opened the door to a range of potential applications, including generating cells and tissues to replace those that are faulty or missing in patients with cancer, diabetes, cardiovascular disease, or other maladies (Figure 1). Visions of new treatments and even cures for debilitating and fatal illnesses proliferated, and some of that work is well under way (see "A Wealth of Research"). Now, ten years later, those visions are looking more like real possibilities as research moves from the lab to the clinic and expands toward a greater understanding of the basic science behind stem cells and its applications.

Biomass to Liquid Fuels and Electrical Power

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, Steven; McDonald, Timothy; Gallagher, Thomas

This research program provided data on immediate applicability of forest biomass production and logistics models. Also, the research further developed and optimized fractionation techniques that can be used to separate biomass feedstocks into their basic chemical constituents. Finally, additional research established systematic techniques to determine economically feasible technologies for production of biomass-derived synthesis gases that will be used for clean, renewable power generation and for production of liquid transportation fuels. Moreover, this research program continued our efforts to educate the next generation of engineers and scientists needed to implement these technologies.

Applications of Piezoelectric Materials in Structural Health Monitoring and Repair: Selected Research Examples

PubMed Central

Duan, Wen Hui; Wang, Quan; Quek, Ser Tong

2010-01-01

The paper reviews the recent applications of piezoelectric materials in structural health monitoring and repair conducted by the authors. First, commonly used piezoelectric materials in structural health monitoring and structure repair are introduced. The analysis of plain piezoelectric sensors and actuators and interdigital transducer and their applications in beam, plate and pipe structures for damage detection are reviewed in detail. Second, an overview is presented on the recent advances in the applications of piezoelectric materials in structural repair. In addition, the basic principle and the current development of the technique are examined. PMID:28883375

A survey of application: genomics and genetic programming, a new frontier.

PubMed

Khan, Mohammad Wahab; Alam, Mansaf

2012-08-01

The aim of this paper is to provide an introduction to the rapidly developing field of genetic programming (GP). Particular emphasis is placed on the application of GP to genomics. First, the basic methodology of GP is introduced. This is followed by a review of applications in the areas of gene network inference, gene expression data analysis, SNP analysis, epistasis analysis and gene annotation. Finally this paper concluded by suggesting potential avenues of possible future research on genetic programming, opportunities to extend the technique, and areas for possible practical applications. Copyright © 2012 Elsevier Inc. All rights reserved.

Applications of geographic information systems (GIS) data and methods in obesity-related research.

PubMed

Jia, P; Cheng, X; Xue, H; Wang, Y

2017-04-01

Geographic information systems (GIS) data/methods offer good promise for public health programs including obesity-related research. This study systematically examined their applications and identified gaps and limitations in current obesity-related research. A systematic search of PubMed for studies published before 20 May 2016, utilizing synonyms for GIS in combination with synonyms for obesity as search terms, identified 121 studies that met our inclusion criteria. We found primary applications of GIS data/methods in obesity-related research included (i) visualization of spatial distribution of obesity and obesity-related phenomena, and basic obesogenic environmental features, and (ii) construction of advanced obesogenic environmental indicators. We found high spatial heterogeneity in obesity prevalence/risk and obesogenic environmental factors. Also, study design and characteristics varied considerably across studies because of lack of established guidance and protocols in the field, which may also have contributed to the mixed findings about environmental impacts on obesity. Existing findings regarding built environment are more robust than those regarding food environment. Applications of GIS data/methods in obesity research are still limited, and related research faces many challenges. More and better GIS data and more friendly analysis methods are needed to expand future GIS applications in obesity-related research. © 2017 World Obesity Federation.

Cellular Therapies Clinical Research Roadmap: Lessons learned on how to move a cellular therapy into a clinical trial

PubMed Central

Ouseph, Stacy; Tappitake, Darah; Armant, Myriam; Wesselschmidt, Robin; Derecho, Ivy; Draxler, Rebecca; Wood, Deborah; Centanni, John M.

2014-01-01

A clinical research roadmap has been developed as a resource for researchers to identify critical areas and potential pitfalls when transitioning a cellular therapy product from the research laboratory, via and Investigational New Drug (IND) application, into early phase clinical trials. The roadmap describes four key areas; basic and preclinical research, resource development, translational research and good manufacturing practice (GMP), and IND assembly and submission. Basic and preclinical research identifies a new therapeutic concept and demonstrates its potential value using a model of the relevant disease. During resource development the appropriate specialists and the required expertise to bring this product into the clinic are identified (e.g., researchers, regulatory specialists, GMP manufacturing staff, clinicians, and clinical trials staff, etc.). Additionally, the funds required to achieve this goal (or a plan to procure them) are identified. In the next phase the plan to translate the research product into a clinical grade therapeutic is developed. Finally regulatory approval to start the trial must be obtained. In the United States this is done by filing an IND application with the Food and Drug Administration. The NHLBI-funded Production Assistance for Cellular Therapies (PACT) program has facilitated the transition of a variety of cellular therapy products from the laboratory into Phase1/2 trials. The five PACT facilities have assisted investigators by performing translational studies and GMP manufacturing to ensure that cellular products met release specifications and were manufactured safely, reproducibly, and at the appropriate scale. The roadmap resulting from this experience is the focus of this article. PMID:25484311

Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data

PubMed Central

Kearse, Matthew; Moir, Richard; Wilson, Amy; Stones-Havas, Steven; Cheung, Matthew; Sturrock, Shane; Buxton, Simon; Cooper, Alex; Markowitz, Sidney; Duran, Chris; Thierer, Tobias; Ashton, Bruce; Meintjes, Peter; Drummond, Alexei

2012-01-01

Summary: The two main functions of bioinformatics are the organization and analysis of biological data using computational resources. Geneious Basic has been designed to be an easy-to-use and flexible desktop software application framework for the organization and analysis of biological data, with a focus on molecular sequences and related data types. It integrates numerous industry-standard discovery analysis tools, with interactive visualizations to generate publication-ready images. One key contribution to researchers in the life sciences is the Geneious public application programming interface (API) that affords the ability to leverage the existing framework of the Geneious Basic software platform for virtually unlimited extension and customization. The result is an increase in the speed and quality of development of computation tools for the life sciences, due to the functionality and graphical user interface available to the developer through the public API. Geneious Basic represents an ideal platform for the bioinformatics community to leverage existing components and to integrate their own specific requirements for the discovery, analysis and visualization of biological data. Availability and implementation: Binaries and public API freely available for download at http://www.geneious.com/basic, implemented in Java and supported on Linux, Apple OSX and MS Windows. The software is also available from the Bio-Linux package repository at http://nebc.nerc.ac.uk/news/geneiousonbl. Contact: peter@biomatters.com PMID:22543367

Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data.

PubMed

Kearse, Matthew; Moir, Richard; Wilson, Amy; Stones-Havas, Steven; Cheung, Matthew; Sturrock, Shane; Buxton, Simon; Cooper, Alex; Markowitz, Sidney; Duran, Chris; Thierer, Tobias; Ashton, Bruce; Meintjes, Peter; Drummond, Alexei

2012-06-15

The two main functions of bioinformatics are the organization and analysis of biological data using computational resources. Geneious Basic has been designed to be an easy-to-use and flexible desktop software application framework for the organization and analysis of biological data, with a focus on molecular sequences and related data types. It integrates numerous industry-standard discovery analysis tools, with interactive visualizations to generate publication-ready images. One key contribution to researchers in the life sciences is the Geneious public application programming interface (API) that affords the ability to leverage the existing framework of the Geneious Basic software platform for virtually unlimited extension and customization. The result is an increase in the speed and quality of development of computation tools for the life sciences, due to the functionality and graphical user interface available to the developer through the public API. Geneious Basic represents an ideal platform for the bioinformatics community to leverage existing components and to integrate their own specific requirements for the discovery, analysis and visualization of biological data. Binaries and public API freely available for download at http://www.geneious.com/basic, implemented in Java and supported on Linux, Apple OSX and MS Windows. The software is also available from the Bio-Linux package repository at http://nebc.nerc.ac.uk/news/geneiousonbl.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pierce, Eric M.; Freshley, Mark D.; Hubbard, Susan S.

In this report, we start by examining previous efforts at linking science and DOE EM research with cleanup activities. Many of these efforts were initiated by creating science and technology roadmaps. A recurring feature of successfully implementing these roadmaps into EM applied research efforts and successful cleanup is the focus on integration. Such integration takes many forms, ranging from combining information generated by various scientific disciplines, to providing technical expertise to facilitate successful application of novel technology, to bringing the resources and creativity of many to address the common goal of moving EM cleanup forward. Successful projects identify and focusmore » research efforts on addressing the problems and challenges that are causing “failure” in actual cleanup activities. In this way, basic and applied science resources are used strategically to address the particular unknowns that are barriers to cleanup. The brief descriptions of the Office of Science basic (Environmental Remediation Science Program [ERSP]) and EM’s applied (Groundwater and Soil Remediation Program) research programs in subsurface science provide context to the five “crosscutting” themes that have been developed in this strategic planning effort. To address these challenges and opportunities, a tiered systematic approach is proposed that leverages basic science investments with new applied research investments from the DOE Office of Engineering and Technology within the framework of the identified basic science and applied research crosscutting themes. These themes are evident in the initial portfolio of initiatives in the EM groundwater and soil cleanup multi-year program plan. As stated in a companion document for tank waste processing (Bredt et al. 2008), in addition to achieving its mission, DOE EM is experiencing a fundamental shift in philosophy from driving to closure to enabling the long-term needs of DOE and the nation.« less

Semiconductor Radiation Detectors: Basic principles and some uses of a recent tool that has revolutionized nuclear physics are described.

PubMed

Goulding, F S; Stone, Y

1970-10-16

The past decade has seen the rapid development and exploitation of one of the most significant tools of nuclear physics, the semiconductor radiation detector. Applications of the device to the analysis of materials promises to be one of the major contributions of nuclear research to technology, and may even assist in some aspects of our environmental problems. In parallel with the development of these applications, further developments in detectors for nuclear research are taking place: the use of very thin detectors for heavyion identification, position-sensitive detectors for nuclear-reaction studies, and very pure germanium for making more satisfactory detectors for many applications suggest major future contributions to physics.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Osmanlioglu, Ahmet Erdal

Pre-treatment of radioactive waste is the first step in waste management program that occurs after waste generation from various applications in Turkey. Pre-treatment and characterization practices are carried out in Radioactive Waste Management Unit (RWMU) at Cekmece Nuclear Research and Training Center (CNRTC) in Istanbul. This facility has been assigned to take all low-level radioactive wastes generated by nuclear applications in Turkey. The wastes are generated from research and nuclear applications mainly in medicine, biology, agriculture, quality control in metal processing and construction industries. These wastes are classified as low- level radioactive wastes. Pre-treatment practices cover several steps. In thismore » paper, main steps of pre-treatment and characterization are presented. Basically these are; collection, segregation, chemical adjustment, size reduction and decontamination operations. (author)« less

[NEW PROGRESS OF ACELLULAR FISH SKIN AS NOVEL TISSUE ENGINEERED SCAFFOLD].

PubMed

Wei, Xiaojuan; Wang, Nanping; He, Lan; Guo, Xiuyu; Gu, Qisheng

2016-11-08

To review the recent research progress of acellular fish skin as a tissue engineered scaffold, and to analyze the feasibility and risk management in clinical application. The research and development, application status of acellular fish skin as a tissue engineered scaffold were comprehensively analyzed, and then several key points were put forward. Acellular fish skin has a huge potential in clinical practice as novel acellular extracellular matrix, but there have been no related research reports up to now in China. As an emerging point of translational medicine, investigation of acellular fish skin is mainly focused on artificial skin, surgical patch, and wound dressings. Development of acellular fish skin-based new products is concerned to be clinical feasible and necessary, but a lot of applied basic researches should be carried out.

An extensible and successful method of identifying collaborators for National Library of Medicine informationist projects

PubMed Central

Williams, Jeff D.; Rambo, Neil H.

2015-01-01

Question/Purpose The New York University (NYU) Health Sciences Library used a new method to arrange in-depth discussions with basic science researchers. The objective was to identify collaborators for a new National Library of Medicine administrative supplement. Setting The research took place at the NYU Health Sciences Library. Methods Using the National Institutes of Health (NIH) RePORTER, forty-four researchers were identified and later contacted through individualized emails. Results Nine researchers responded to the email followed by six in-person or phone discussions. At the conclusion of this process, two researchers submitted applications for supplemental funding, and both of these applications were successful. Conclusions This method confirmed these users could benefit from the skills and knowledge of health sciences librarians, but they are largely unaware of this. PMID:26213507

Applications of Light Emitting Diodes in Health Care.

PubMed

Dong, Jianfei; Xiong, Daxi

2017-11-01

Light emitting diodes (LEDs) have become the main light sources for general lighting, due to their high lumen efficiency and long life time. Moreover, their high bandwidth and the availability of diverse wavelength contents ranging from ultraviolet to infrared empower them with great controllability in tuning brightness, pulse durations and spectra. These parameters are the essential ingredients of the applications in medical imaging and therapies. Despite the fast advances in both LED technologies and their applications, few reviews have been seen to link the controllable emission properties of LEDs to these applications. The objective of this paper is to bridge this gap by reviewing the main control techniques of LEDs that enable creating enhanced lighting patterns for imaging and generating effective photon doses for photobiomodulation. This paper also provides the basic mechanisms behind the effective LED therapies in treating cutaneous and neurological diseases. The emerging field of optogenetics is also discussed with a focus on the application of LEDs. The multidisciplinary topics reviewed in this paper can help the researchers in LEDs, imaging, light therapy and optogenetics better understand the basic principles in each other's field; and hence to stimulate the application of LEDs in health care.

Quality control of human tissues--experience from the Indiana University Cancer Center-Lilly Research Labs human tissue bank.

PubMed

Sandusky, George E; Teheny, Katie Heinz; Esterman, Mike; Hanson, Jeff; Williams, Stephen D

2007-01-01

The success of molecular research and its applications in both the clinical and basic research arenas is strongly dependent on the collection, handling, storage, and quality control of fresh human tissue samples. This tissue bank was set up to bank fresh surgically obtained human tissue using a Clinical Annotated Tissue Database (CATD) in order to capture the associated patient clinical data and demographics using a one way patient encryption scheme to protect patient identification. In this study, we determined that high quality of tissue samples is imperative for both genomic and proteomic molecular research. This paper also contains a brief compilation of the literature involved in the patient ethics, patient informed consent, patient de-identification, tissue collection, processing, and storage as well as basic molecular research generated from the tissue bank using good clinical practices. The current applicable rules, regulations, and guidelines for handling human tissues are briefly discussed. More than 6,610 cancer patients have been consented (97% of those that were contacted by the consenter) and 16,800 tissue specimens have been banked from these patients in 9 years. All samples collected in the bank were QC'd by a pathologist. Approximately 1,550 tissue samples have been requested for use in basic, clinical, and/or biomarker cancer research studies. Each tissue aliquot removed from the bank for a research study were evaluated by a second H&E, if the samples passed the QC, they were submitted for genomic and proteomic molecular analysis/study. Approximately 75% of samples evaluated were of high histologic quality and used for research studies. Since 2003, we changed the patient informed consent to allow the tissue bank to gather more patient clinical follow-up information. Ninety two percent of the patients (1,865 patients) signed the new informed consent form and agreed to be re-contacted for follow-up information on their disease state. In addition, eighty five percent of patients (1,584) agreed to be re-contacted to provide a biological fluid sample to be used for biomarker research.

Construction of databases: advances and significance in clinical research.

PubMed

Long, Erping; Huang, Bingjie; Wang, Liming; Lin, Xiaoyu; Lin, Haotian

2015-12-01

Widely used in clinical research, the database is a new type of data management automation technology and the most efficient tool for data management. In this article, we first explain some basic concepts, such as the definition, classification, and establishment of databases. Afterward, the workflow for establishing databases, inputting data, verifying data, and managing databases is presented. Meanwhile, by discussing the application of databases in clinical research, we illuminate the important role of databases in clinical research practice. Lastly, we introduce the reanalysis of randomized controlled trials (RCTs) and cloud computing techniques, showing the most recent advancements of databases in clinical research.

Quarterly progress report for the Chemical and Energy Research Section of the Chemical Technology Division, April--June 1997

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jubin, R.T.

The Chemical and Energy Research Section conducts basic and applied research and development in chemical engineering, applied chemistry, and bioprocessing, with an emphasis on energy-driven technologies and advanced chemical separations for nuclear and waste applications. The report describes the various tasks performed within six major areas of research: Hot Cell Operations, Process Chemistry and thermodynamics, Separations and Materials Synthesis, Solution Thermodynamics, biotechnology Research, and Molecular Studies. The name of a technical contact is included with each task described, and readers are encouraged to contact these individuals if they need additional information.

Basic research and data analysis for the earth and ocean physics applications program and for the National Geodetic Satellite Program

NASA Technical Reports Server (NTRS)

1976-01-01

Data analysis and supporting research in connection with the following objectives are discussed: (1) provide a precise and accurate geometric description of the earth's surface, (2) provide a precise and accurate mathematical description of the earth's gravitational field, and (3) determine time variations of the geometry of the ocean surface, the solid earth, the gravity field and other geophysical parameters.

Semiannual report, 1 April - 30 September 1991

NASA Technical Reports Server (NTRS)

1991-01-01

The major categories of the current Institute for Computer Applications in Science and Engineering (ICASE) research program are: (1) numerical methods, with particular emphasis on the development and analysis of basic numerical algorithms; (2) control and parameter identification problems, with emphasis on effective numerical methods; (3) computational problems in engineering and the physical sciences, particularly fluid dynamics, acoustics, and structural analysis; and (4) computer systems and software for parallel computers. Research in these areas is discussed.

Biological imaging with coherent Raman scattering microscopy: a tutorial

PubMed Central

Alfonso-García, Alba; Mittal, Richa; Lee, Eun Seong; Potma, Eric O.

2014-01-01

Abstract. Coherent Raman scattering (CRS) microscopy is gaining acceptance as a valuable addition to the imaging toolset of biological researchers. Optimal use of this label-free imaging technique benefits from a basic understanding of the physical principles and technical merits of the CRS microscope. This tutorial offers qualitative explanations of the principles behind CRS microscopy and provides information about the applicability of this nonlinear optical imaging approach for biological research. PMID:24615671

Modeling Visual, Vestibular and Oculomotor Interactions in Self-Motion Estimation

NASA Technical Reports Server (NTRS)

Perrone, John

1997-01-01

A computational model of human self-motion perception has been developed in collaboration with Dr. Leland S. Stone at NASA Ames Research Center. The research included in the grant proposal sought to extend the utility of this model so that it could be used for explaining and predicting human performance in a greater variety of aerospace applications. This extension has been achieved along with physiological validation of the basic operation of the model.

Drosophila Genetic Resource and Stock Center; The National BioResource Project.

PubMed

Yamamoto, Masa-Toshi

2010-01-01

The fruit fly, Drosophila melanogaster, is not categorized as a laboratory animal, but it is recognised as one of the most important model organisms for basic biology, life science, and biomedical research. This tiny fly continues to occupy a core place in genetics and genomic approaches to studies of biology and medicine. The basic principles of genetics, including the variations of phenotypes, mutations, genetic linkage, meiotic chromosome segregation, chromosome aberrations, recombination, and precise mapping of genes by genetic as well as cytological means, were all derived from studies of Drosophila. Recombinant DNA technology was developed in the 1970s and Drosophila DNA was the first among multicellular organisms to be cloned. It provided a detailed characterization of genes in combination of classical cytogenetic data. Drosophila thus became the pioneering model organism for various fields of life science research into multicellular organisms. Here, I briefly describe the history of Drosophila research and provide a few examples of the application of the abundant genetic resources of Drosophila to basic biology and medical investigations. A Japanese national project, the National BioResource Project (NBRP) for collection, maintainance, and provision of Drosophila resources, that is well known and admired by researchers in other countries as an important project, is also briefly described.

Applications of artificial neural networks (ANNs) in food science.

PubMed

Huang, Yiqun; Kangas, Lars J; Rasco, Barbara A

2007-01-01

Artificial neural networks (ANNs) have been applied in almost every aspect of food science over the past two decades, although most applications are in the development stage. ANNs are useful tools for food safety and quality analyses, which include modeling of microbial growth and from this predicting food safety, interpreting spectroscopic data, and predicting physical, chemical, functional and sensory properties of various food products during processing and distribution. ANNs hold a great deal of promise for modeling complex tasks in process control and simulation and in applications of machine perception including machine vision and electronic nose for food safety and quality control. This review discusses the basic theory of the ANN technology and its applications in food science, providing food scientists and the research community an overview of the current research and future trend of the applications of ANN technology in the field.

Teaching ethical aptitude to graduate student researchers.

PubMed

Weyrich, Laura S; Harvill, Eric T

2013-01-01

Limited time dedicated to each training areas, irrelevant case-studies, and ethics "checklists" have resulted in bare-bones Responsible Conduct of Research (RCR) training for present biomedical graduate student researchers. Here, we argue that science graduate students be taught classical ethical theory, such as virtue ethics, consequentialist theory, and deontological theory, to provide a basic framework to guide researchers through ethically complex situations and examine the applicability, implications, and societal ramifications of their research. Using a relevant biomedical research example to illustrate this point, we argue that proper ethics training for graduate student researchers not only will enhance current RCR training, but train more creative, responsible scientists.

Basic research planning in mathematical pattern recognition and image analysis

NASA Technical Reports Server (NTRS)

Bryant, J.; Guseman, L. F., Jr.

1981-01-01

Fundamental problems encountered while attempting to develop automated techniques for applications of remote sensing are discussed under the following categories: (1) geometric and radiometric preprocessing; (2) spatial, spectral, temporal, syntactic, and ancillary digital image representation; (3) image partitioning, proportion estimation, and error models in object scene interference; (4) parallel processing and image data structures; and (5) continuing studies in polarization; computer architectures and parallel processing; and the applicability of "expert systems" to interactive analysis.

A guideline for analyzing circadian wheel-running behavior in rodents under different lighting conditions

PubMed Central

Jud, Corinne; Schmutz, Isabelle; Hampp, Gabriele; Oster, Henrik

2005-01-01

Most behavioral experiments within circadian research are based on the analysis of locomotor activity. This paper introduces scientists to chronobiology by explaining the basic terminology used within the field. Furthermore, it aims to assist in designing, carrying out, and evaluating wheel-running experiments with rodents, particularly mice. Since light is an easily applicable stimulus that provokes strong effects on clock phase, the paper focuses on the application of different lighting conditions. PMID:16136228

Material design and structural color inspired by biomimetic approach

PubMed Central

Saito, Akira

2011-01-01

Generation of structural color is one of the essential functions realized by living organisms, and its industrial reproduction can result in numerous applications. From this viewpoint, the mechanisms, materials, analytical methods and fabrication technologies of the structural color are reviewed in this paper. In particular, the basic principles of natural photonic materials, the ideas developed from these principles, the directions of applications and practical industrial realizations are presented by summarizing the recent research results. PMID:27877459

Non-invasive electrical and magnetic stimulation of the brain, spinal cord, roots and peripheral nerves: Basic principles and procedures for routine clinical and research application. An updated report from an I.F.C.N. Committee.

PubMed

Rossini, P M; Burke, D; Chen, R; Cohen, L G; Daskalakis, Z; Di Iorio, R; Di Lazzaro, V; Ferreri, F; Fitzgerald, P B; George, M S; Hallett, M; Lefaucheur, J P; Langguth, B; Matsumoto, H; Miniussi, C; Nitsche, M A; Pascual-Leone, A; Paulus, W; Rossi, S; Rothwell, J C; Siebner, H R; Ugawa, Y; Walsh, V; Ziemann, U

2015-06-01

These guidelines provide an up-date of previous IFCN report on "Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application" (Rossini et al., 1994). A new Committee, composed of international experts, some of whom were in the panel of the 1994 "Report", was selected to produce a current state-of-the-art review of non-invasive stimulation both for clinical application and research in neuroscience. Since 1994, the international scientific community has seen a rapid increase in non-invasive brain stimulation in studying cognition, brain-behavior relationship and pathophysiology of various neurologic and psychiatric disorders. New paradigms of stimulation and new techniques have been developed. Furthermore, a large number of studies and clinical trials have demonstrated potential therapeutic applications of non-invasive brain stimulation, especially for TMS. Recent guidelines can be found in the literature covering specific aspects of non-invasive brain stimulation, such as safety (Rossi et al., 2009), methodology (Groppa et al., 2012) and therapeutic applications (Lefaucheur et al., 2014). This up-dated review covers theoretical, physiological and practical aspects of non-invasive stimulation of brain, spinal cord, nerve roots and peripheral nerves in the light of more updated knowledge, and include some recent extensions and developments. Copyright © 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Advanced fabrication techniques for hydrogen-cooled engine structures

NASA Technical Reports Server (NTRS)

Buchmann, O. A.; Arefian, V. V.; Warren, H. A.; Vuigner, A. A.; Pohlman, M. J.

1985-01-01

Described is a program for development of coolant passage geometries, material systems, and joining processes that will produce long-life hydrogen-cooled structures for scramjet applications. Tests were performed to establish basic material properties, and samples constructed and evaluated to substantiate fabrication processes and inspection techniques. Results of the study show that the basic goal of increasing the life of hydrogen-cooled structures two orders of magnitude relative to that of the Hypersonic Research Engine can be reached with available means. Estimated life is 19000 cycles for the channels and 16000 cycles for pin-fin coolant passage configurations using Nickel 201. Additional research is required to establish the fatigue characteristics of dissimilar-metal coolant passages (Nickel 201/Inconel 718) and to investigate the embrittling effects of the hydrogen coolant.

Basic Science and Clinical Application of Stem Cells in Veterinary Medicine

NASA Astrophysics Data System (ADS)

Ribitsch, I.; Burk, J.; Delling, U.; Geißler, C.; Gittel, C.; Jülke, H.; Brehm, W.

Stem cells play an important role in veterinary medicine in different ways. Currently several stem cell therapies for animal patients are being developed and some, like the treatment of equine tendinopathies with mesenchymal stem cells (MSCs), have already successfully entered the market. Moreover, animal models are widely used to study the properties and potential of stem cells for possible future applications in human medicine. Therefore, in the young and emerging field of stem cell research, human and veterinary medicine are intrinsically tied to one another. Many of the pioneering innovations in the field of stem cell research are achieved by cooperating teams of human and veterinary medical scientists.

Low cost heterogenous catalyst from (Achatina Fulica) snail shell and its application for biodiesel conversion via microwave irradiation

NASA Astrophysics Data System (ADS)

Fatimah, Is; Kurniastuti, E. A.; Basthiani, I. A.; Fakhri, A.

2017-11-01

Research on preparation of heterogenous catalyst from Achatina Fulica snail shell and its application biodiesel conversion has been investigation. Research aimed to obtain low cost and reusable catalyst for biodiesel production. The catalyst was prepared by grinding and calcining the snail shell at 900°C for 2 hours. The obtained solid was analysed by using XRD, SEM-EDX. FTIR, and also basicity measurement. Catalyst was used in the cenvertion of rice bran oil transesterification at varied volume of oil methanol ratio of 20-80 under microwave and reflux methode. The transesterification result were analyzed by using GCMS.

Engineering Data Compendium. Human Perception and Performance, Volume 2

NASA Technical Reports Server (NTRS)

Boff, Kenneth R. (Editor); Lincoln, Janet E. (Editor)

1988-01-01

The concept underlying the Engineering Data Compendium was the product of a Research and Development program (Integrated Perceptual Information for Designers project) aimed at facilitating the application of basic research findings in human performance to the design of military crew systems. The principal objective was to develop a workable strategy for: (1) identifying and distilling information of potential value to system design from existing research literature, and (2) presenting this technical information in a way that would aid its accessibility, interpretability, and applicability by system designers. The present volumes of the Engineering Data Compendium represent the first implementation of this strategy. This is Volume 2, which contains sections on Information Storage and Retrieval, Spatial Awareness, Perceptual Organization, and Attention and Allocation of Resources.

Engineering data compendium. Human perception and performance, volume 3

NASA Technical Reports Server (NTRS)

Boff, Kenneth R. (Editor); Lincoln, Janet E. (Editor)

1988-01-01

The concept underlying the Engineering Data Compendium was the product of a research and development program (Integrated Perceptual Information for Designers project) aimed at facilitating the application of basic research findings in human performance to the design of military crew systems. The principal objective was to develop a workable strategy for: (1) identifying and distilling information of potential value to system design from existing research literature, and (2) presenting this technical information in a way that would aid its accessibility, interpretability, and applicability by system designers. The present four volumes of the Engineering Data Compendium represent the first implementation of this strategy. This is Volume 3, containing sections on Human Language Processing, Operator Motion Control, Effects of Environmental Stressors, Display Interfaces, and Control Interfaces (Real/Virtual).

Engineering data compendium. Human perception and performance. User's guide

NASA Technical Reports Server (NTRS)

Boff, Kenneth R. (Editor); Lincoln, Janet E. (Editor)

1988-01-01

The concept underlying the Engineering Data Compendium was the product of a research and development program (Integrated Perceptual Information for Designers project) aimed at facilitating the application of basic research findings in human performance to the design and military crew systems. The principal objective was to develop a workable strategy for: (1) identifying and distilling information of potential value to system design from the existing research literature, and (2) presenting this technical information in a way that would aid its accessibility, interpretability, and applicability by systems designers. The present four volumes of the Engineering Data Compendium represent the first implementation of this strategy. This is the first volume, the User's Guide, containing a description of the program and instructions for its use.

32 CFR Appendix A to Part 272 - Principles for the Conduct and Support of Basic Research

Code of Federal Regulations, 2010 CFR

2010-07-01

... Research A Appendix A to Part 272 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE... Research 1. Basic research is an investment. The DoD Components are to view and manage basic research...

Applications of HCMM satellite data to the study of urban heating patterns

NASA Technical Reports Server (NTRS)

Carlson, T. N. (Principal Investigator)

1980-01-01

A research summary is presented and is divided into two major areas, one developmental and the other basic science. In the first three sub-categories are discussed: image processing techniques, especially the method whereby surface temperature image are converted to images of surface energy budget, moisture availability and thermal inertia; model development; and model verification. Basic science includes the use of a method to further the understanding of the urban heat island and anthropogenic modification of the surface heating, evaporation over vegetated surfaces, and the effect of surface heat flux on plume spread.

[Research on basic questions of intellectual property rights of acupuncture and moxibustion].

PubMed

Dong, Guo-Feng; Wu, Xiao-Dong; Han, Yan-Jing; Meng, Hong; Wang, Xin

2011-12-01

Along with the modernization and internationalization of acupuncture-moxibustion (acu-moxibustion), the issue of intellectual property rights has been becoming prominent and remarkable increasingly. In the present paper, the authors explain the basic issues of acu-moxibustion learning from the concept, scope, subject, object, contents and acquisition way of intellectual property rights. To make clear these questions will help us inherit and carry forward the existing civilization achievements of acu-moxibustion, and unceasingly bring forth new ideas and further improvement in clinical application, so as to serve the people's health in a better way.

The VELA Program. A Twenty-Five Year Review of Basic Research

DTIC Science & Technology

1985-01-01

Z7 - db -gP W- -~ g F 7 f. -t-4? - Un~imue h 9 * so :;-. 6 do. 0AAA3LO C Best Available Copy I@ The VELA Program A Twenty-Five Vear Review of Basic...Modeling in the Inelastic Region of Underground Nuclear Explosions L.I. Burdick, I.S. Barker, D. V. Helmbewr, and D. G . Harkridff 130 Spall Contribution to...Contas Xiii In-Situ Strain Paths and Stress Bounds with Application to Desert Alit iviutm. JG. Truio 344 Model ",- g L. Codas of P-SV and SH by Vertical

Profiles of 1975-76 Supplemental Basic Grant Applicants.

ERIC Educational Resources Information Center

Walters, Pamela Barnhouse

The nature and extent of misreporting by applicants for the Basic Educational Opportunity Grant program was investigated. Types of potential program abuse were assessed, along with the accuracy of income estimates that students make on Supplemental Basic Grant applications, which are the basis for determining a student's eligibility. Attention was…

Learning Theories 101: Application to Everyday Teaching and Scholarship

ERIC Educational Resources Information Center

Kay, Denise; Kibble, Jonathan

2016-01-01

Shifts in educational research, in how scholarship in higher education is defined, and in how funding is appropriated suggest that educators within basic science fields can benefit from increased understanding of learning theory and how it applies to classroom practice. This article uses a mock curriculum design scenario as a framework for the…

Regulatory Implications of Using Constructed Wetlands to Treat Selenium-Laden Wastewater

Treesearch

A. Dennis Lemly; Harry M. Ohlendorf

2002-01-01

The practice of using constructed wetlands to treat selenium-laden wastewater is gaining popularity in the linited States and elsewhere. However, proponents of treatment wetlands often overlook important ecological liabilities and regulatory implications when developing new methods and applications. Their research studies typically seek to answer a basic performance...

Beyond 100 Tesla: Scientific experiments using single-turn coils

NASA Astrophysics Data System (ADS)

Portugall, Oliver; Solane, Pierre Yves; Plochocka, Paulina; Maude, Duncan K.; Nicholas, Robin J.

2013-01-01

Current opportunities and recent examples for research in magnetic fields well above 100 T using single-turn coils are discussed. After a general introduction into basic principles and technical constraints associated with the generation of Megagauss fields we discuss data obtained at the LNCMI Toulouse, where such fields are routinely used for scientific applications.

Supporting Information Governance through Records and Information Management. Research Bulletin

ERIC Educational Resources Information Center

Kaczmarek, Joanne

2014-01-01

The expanding scope of IT initiatives in higher education institutions now goes well beyond basic desktop and enterprise applications. IT is often asked to focus on efforts to establish good information-governance practices. The many aspects of information governance are often found in a records and information management (RIM) program, but not…

Perceptions of Students towards ICT Competencies at the University

ERIC Educational Resources Information Center

Torres-Gastelú, Carlos Arturo; Kiss, Gábor

2016-01-01

The purpose of this study is to identify the perceptions of university students towards their ICT Competencies from two universities, one in Mexico and the other in Hungary. The research type is quantitative and exploratory. The instrument consists of 14 questions related to three types of competencies: Basic, Application and Ethical. The sample…

Production of germline ablated male pigs via Crispr/Cas editing of the NANOS2 gene

USDA-ARS?s Scientific Manuscript database

The availability of alternative models to flies, worms, and mice for studying germ cell biology is important for translating findings to higher order mammals. In this context, investigations in pigs and other livestock species can also serve to find applications for both basic biomedical research ...

Research Findings on Neurolinguistic Programming: Nonsupportive Data or an Untestable Theory?

ERIC Educational Resources Information Center

Sharpley, Christopher F.

1987-01-01

Examines the experimental literature on neurolinguistic programming (NLP). Sharpley (l984) and Einspruch and Forman (l985) concluded that the effectiveness of this therapy was yet to be demonstrated. Presents data from seven recent studies that further question the basic tenets of NLP and their application in counseling situations. (Author/KS)

78 FR 65343 - Center for Scientific Review; Amended Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-31

...; Amended Notice of Meeting Notice is hereby given of a change in the meeting of the Center for Scientific Review Special Emphasis Panel, Revision Applications for Basic, Social and Behavioral Research on the Social, Cultural, Biological and Psychological Mechanisms of Stigma, October 20, 2013, 6:00 p.m. to...

Application of an Online Reference for Reviewing Basic Statistical Principles of Operating Room Management

ERIC Educational Resources Information Center

Dexter, Franklin; Masursky, Danielle; Wachtel, Ruth E.; Nussmeier, Nancy A.

2010-01-01

Operating room (OR) management differs from clinical anesthesia in that statistical literacy is needed daily to make good decisions. Two of the authors teach a course in operations research for surgical services to anesthesiologists, anesthesia residents, OR nursing directors, hospital administration students, and analysts to provide them with the…

Fast ion transport in solids: electrolytes and electrodes. Program and abstracts. [Lake Geneva, Wisconsin, May 21-25, 1979

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

1979-01-01

Abstracts for the 47 invited papers and 111 contributed papers (presented in poster sessions) are given in this publication, along with the program schedule. Papers deal with both basic research and applications, the most important of the latter being electric batteries. (RWR)

Open Source for Knowledge and Learning Management: Strategies beyond Tools

ERIC Educational Resources Information Center

Lytras, Miltiadis, Ed.; Naeve, Ambjorn, Ed.

2007-01-01

In the last years, knowledge and learning management have made a significant impact on the IT research community. "Open Source for Knowledge and Learning Management: Strategies Beyond Tools" presents learning and knowledge management from a point of view where the basic tools and applications are provided by open source technologies.…

Using case-mix information in strategic hospital marketing. Deriving market research from patient data.

PubMed

Little, A

1992-01-01

Hospital survival requires adaptation, adaptation requires understanding, and understanding requires information. These are the basic equations behind hospital strategic marketing, and one of the answers may lie in hospitals' own patient-data systems. Marketers' and administrators' enlightened application of case-mix information could become one more hospital survival tool.

Currency Arbitrage Detection Using a Binary Integer Programming Model

ERIC Educational Resources Information Center

Soon, Wanmei; Ye, Heng-Qing

2011-01-01

In this article, we examine the use of a new binary integer programming (BIP) model to detect arbitrage opportunities in currency exchanges. This model showcases an excellent application of mathematics to the real world. The concepts involved are easily accessible to undergraduate students with basic knowledge in Operations Research. Through this…

Journal of the Society for Accelerative Learning and Teaching; Volume 12, Number 1-4.

ERIC Educational Resources Information Center

Schuster, Don, Ed.

1987-01-01

The basic focus on this journal, which publishes a wide variety of articles on suggestive and accelerative learning, is Suggestopedia theory, research, and application. Articles in the volume presented here include: "The Effects of Superlearning on Retention/Hypermnesia of Rare English Words in College Students" (Lynn D. Anderson);…

Flipped Classrooms and Student Learning: Not Just Surface Gains

ERIC Educational Resources Information Center

McLean, Sarah; Attardi, Stefanie M.; Faden, Lisa; Goldszmidt, Mark

2016-01-01

The flipped classroom is a relatively new approach to undergraduate teaching in science. This approach repurposes class time to focus on application and discussion; the acquisition of basic concepts and principles is done on the students' own time before class. While current flipped classroom research has focused on student preferences and…

Perspectives and methods of scaling

Treesearch

Jianguo Wu; Harbin Li

2006-01-01

Transferring information between or across scales or organizational levels is inevitable in both basic research and its applications, a process generally known as "scaling" (Wu and Li, Chapter 1). Scaling is the essence of prediction and understanding both of which require cross-scale translation of information, and is at the core of ecological theory and...

Photonics and terahertz technologies: part 2

NASA Astrophysics Data System (ADS)

Romaniuk, Ryszard S.

2011-10-01

This digest paper debates basic features of the terahertz band of frequencies and compares it to the classical photonics. There are presented fundamental characteristics of the basic terahertz system consisting of a THz source, propagation media, transmission lines, THz signal processing, and detectors. Such a system finds research application, but also practical in two main areas: terahertz imaging - transmission and reflective, and as a close range THz radar, but also as sensory systems mainly for molecular sensing. There were launched in this country a few THz research projects concerning the THz sources, detectors and their applications. Among these projects there is an infrastructural one called FOTEH, opened at the WUT. The details of this project are debated and the consequences of its realization in this country. The first part of the paper is an introduction debating THz band and comparing it with the photonics one. The second part presents the assumptions of the infrastructural FOTEH project on Photonics and Terahertz Technologies. The project is expected to have impact on the development of photonics and relate fields in Poland.

From Bioengineering to CRISPR/Cas9 – A Personal Retrospective of 20 Years of Research in Programmable Genome Targeting

PubMed Central

Jeltsch, Albert

2018-01-01

Genome targeting of restriction enzymes and DNA methyltransferases has many important applications including genome and epigenome editing. 15–20 years ago, my group was involved in the development of approaches for programmable genome targeting, aiming to connect enzymes with an oligodeoxynucleotide (ODN), which could form a sequence-specific triple helix at the genomic target site. Importantly, the target site of such enzyme-ODN conjugate could be varied simply by altering the ODN sequence promising great applicative values. However, this approach was facing many problems including the preparation and purification of the enzyme-ODN conjugates, their efficient delivery into cells, slow kinetics of triple helix formation and the requirement of a poly-purine target site sequence. Hence, for several years genome and epigenome editing approaches mainly were based on Zinc fingers and TAL proteins as targeting devices. More recently, CRISPR/Cas systems were discovered, which use a bound RNA for genome targeting that forms an RNA/DNA duplex with one DNA strand of the target site. These systems combine all potential advantages of the once imagined enzyme-ODN conjugates and avoid all main disadvantageous. Consequently, the application of CRISPR/Cas in genome and epigenome editing has exploded in recent years. We can draw two important conclusions from this example of research history. First, evolution still is the better bioengineer than humans and, whenever tested in parallel, natural solutions outcompete engineered ones. Second, CRISPR/Cas system were discovered in pure, curiosity driven, basic research, highlighting that it is basic, bottom-up research paving the way for fundamental innovation. PMID:29434619

National Science and Technology Institute for Translational Medicine (INCT-TM): advancing the field of translational medicine and mental health.

PubMed

Hallak, Jaime E C; Crippa, José Alexandre S; Quevedo, João; Roesler, Rafael; Schröder, Nadja; Nardi, Antonio Egidio; Kapczinski, Flávio

2010-03-01

Translational medicine has been described as the integrated application of innovative pharmacology tools, biomarkers, clinical methods, clinical technologies and study designs to improve the understanding of medical disorders. In medicine, translational research offers an opportunity for applying the findings obtained from basic research to every-day clinical applications. The National Science and Technology Institute for Translational Medicine is comprised of six member institutions (Universidade Federal do Rio Grande do Sul, Universidade de São Paulo-Ribeirão Preto, Universidade Federal do Rio de Janeiro, Pontifícia Universidade Católica do Rio Grande do Sul, Universidade Estadual de Santa Catarina and a core facility that serves all centers). The objectives of the project are divided into four areas: Institutional, Research, Human Resources and Technology for the Community and Productive Sector. In this manuscript, we describe some of the approaches used to attain the main objectives of the National Science and Technology Institute for Translational Medicine, which include the development of 1) animal models for bipolar disorder; 2) strategies to investigate neurobehavioral function and cognitive dysfunction associated with brain disorders; 3) experimental models of brain function and behavior, neuropsychiatric disorders, cell proliferation, and cancer; 4) Simulated Public Speaking and 5) Virtual reality simulation for inducing panic disorder and agoraphobia. The main focus of the National Science and Technology Institute for Translational Medicine is the development of more useful methods that allow for a better application of basic research-based knowledge to the medical field.

R 5T 4 compounds - unique multifunctional intermetallics for basic research and applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mudryk, Yaroslav

The unique properties of the rare-earth elements and their alloys have brought them from relative obscurity to high profile use in common high-tech applications. The broad technological impact of these remarkable materials may have never been known by the general public if not for the supply concerns that placed the rare-earth materials on the front page of newspapers and magazines. Neodymium and dysprosium, two essential components of Nd 2Fe 14B-based high-performance permanent magnets, have drawn much attention and have been deemed critical materials for many energy-related applications. Ironically, the notoriety of rare-earth elements and their alloys is the result ofmore » a global movement to reduce their use in industrial applications and, thus, ease concerns about their supply and ultimately to reduce their position in high-tech supply chains. Research into the applications of lanthanide alloys has been de-emphasized recently due to the perception that industry is moving away from the use of rare-earth elements in new products. While lanthanide supply challenges justify efforts to diversify the supply chain, a strategy to completely replace the materials overlooks the reasons rare earths became important in the first place -- their unique properties are too beneficial to ignore. Rare-earth alloys and compounds possess truly exciting potential for basic science exploration and application development such as solid-state caloric cooling. In this brief review, we touch upon several promising systems containing lanthanide elements that show important and interesting magnetism-related phenomena.« less

[The development of molecular human genetics and its significance for perspectives of modern medicine].

PubMed

Coutelle, C; Speer, A; Grade, K; Rosenthal, A; Hunger, H D

1989-01-01

The introduction of molecular human genetics has become a paradigma for the application of genetic engineering in medicine. The main principles of this technology are the isolation of molecular probes, their application in hybridization reactions, specific gene-amplification by the polymerase chain reaction, and DNA sequencing reactions. These methods are used for the analysis of monogenic diseases by linkage studies and the elucidation of the molecular defect causing these conditions, respectively. They are also the basis for genomic diagnosis of monogenic diseases, introduced into the health care system of the GDR by a national project on Duchenne/Becker muscular dystrophy, Cystic Fibrosis and Phenylketonuria. The rapid development of basic research on the molecular analysis of the human genome and genomic diagnosis indicates, that human molecular genetics is becoming a decisive basic discipline of modern medicine.

Off-target Effects in CRISPR/Cas9-mediated Genome Engineering

PubMed Central

Zhang, Xiao-Hui; Tee, Louis Y; Wang, Xiao-Gang; Huang, Qun-Shan; Yang, Shi-Hua

2015-01-01

CRISPR/Cas9 is a versatile genome-editing technology that is widely used for studying the functionality of genetic elements, creating genetically modified organisms as well as preclinical research of genetic disorders. However, the high frequency of off-target activity (≥50%)—RGEN (RNA-guided endonuclease)-induced mutations at sites other than the intended on-target site—is one major concern, especially for therapeutic and clinical applications. Here, we review the basic mechanisms underlying off-target cutting in the CRISPR/Cas9 system, methods for detecting off-target mutations, and strategies for minimizing off-target cleavage. The improvement off-target specificity in the CRISPR/Cas9 system will provide solid genotype–phenotype correlations, and thus enable faithful interpretation of genome-editing data, which will certainly facilitate the basic and clinical application of this technology. PMID:26575098

A review of gradient stiffness hydrogels used in tissue engineering and regenerative medicine.

PubMed

Xia, Tingting; Liu, Wanqian; Yang, Li

2017-06-01

Substrate stiffness is known to impact characteristics including cell differentiation, proliferation, migration and apoptosis. Hydrogels are polymeric materials distinguished by high water content and diverse physical properties. Gradient stiffness hydrogels are designed by the need to develop biologically friendly materials as extracellular matrix (ECM) alternatives to replace the separated and narrow-ranged hydrogel substrates. Important new discoveries in cell behaviors have been realized with model gradient stiffness hydrogel systems from the two-dimensional (2D) to three-dimensional (3D) scale. Basic and clinical applications for gradient stiffness hydrogels in tissue engineering and regenerative medicine continue to drive the development of stiffness and structure varied hydrogels. Given the importance of gradient stiffness hydrogels in basic research and biomedical applications, there is a clear need for systems for gradient stiffness hydrogel design strategies and their applications. This review will highlight past work in the field of gradient stiffness hydrogels fabrication methods, mechanical property test, applications as well as areas for future study. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1799-1812, 2017. © 2017 Wiley Periodicals, Inc.

Shear Model Development of Limestone Joints with Incorporating Variations of Basic Friction Coefficient and Roughness Components During Shearing

NASA Astrophysics Data System (ADS)

Mehrishal, Seyedahmad; Sharifzadeh, Mostafa; Shahriar, Korosh; Song, Jae-Jon

2017-04-01

In relation to the shearing of rock joints, the precise and continuous evaluation of asperity interlocking, dilation, and basic friction properties has been the most important task in the modeling of shear strength. In this paper, in order to investigate these controlling factors, two types of limestone joint samples were prepared and CNL direct shear tests were performed on these joints under various shear conditions. One set of samples were travertine and another were onyx marble with slickensided surfaces, surfaces ground to #80, and rough surfaces were tested. Direct shear experiments conducted on slickensided and ground surfaces of limestone indicated that by increasing the applied normal stress, under different shearing rates, the basic friction coefficient decreased. Moreover, in the shear tests under constant normal stress and shearing rate, the basic friction coefficient remained constant for the different contact sizes. The second series of direct shear experiments in this research was conducted on tension joint samples to evaluate the effect of surface roughness on the shear behavior of the rough joints. This paper deals with the dilation and roughness interlocking using a method that characterizes the surface roughness of the joint based on a fundamental combined surface roughness concept. The application of stress-dependent basic friction and quantitative roughness parameters in the continuous modeling of the shear behavior of rock joints is an important aspect of this research.

Thin film bioreactors in space

NASA Technical Reports Server (NTRS)

Hughes-Fulford, M.; Scheld, H. W.

1989-01-01

Studies from the Skylab, SL-3 and D-1 missions have demonstrated that biological organisms grown in microgravity have changes in basic cellular functions such as DNA, mRNA and protein synthesis, cytoskeleton synthesis, glucose utilization, and cellular differentiation. Since microgravity could affect prokaryotic and eukaryotic cells at a subcellular and molecular level, space offers an opportunity to learn more about basic biological systems with one inmportant variable removed. The thin film bioreactor will facilitate the handling of fluids in microgravity, under constant temperature and will allow multiple samples of cells to be grown with variable conditions. Studies on cell cultures grown in microgravity would make it possible to identify and quantify changes in basic biological function in microgravity which are needed to develop new applications of orbital research and future biotechnology.

Twenty-first century macro-trends in the institutional fabric of science: bibliometric monitoring and analysis.

PubMed

Tijssen, Robert J W; Winnink, Jos

Some say that world science has become more 'applied', or at least more 'application-oriented', in recent years. Replacing the ill-defined distinction between 'basic research' and 'applied research', we introduce 'research application orientation' domains as an alternative conceptual and analytical framework for examining research output growth patterns. To distinguish possible developmental trajectories we define three institutional domains: 'university', 'industry', 'hospitals'. Our macro-level bibliometric analysis takes a closer look at general trends within and across some 750 of the world's largest research-intensive universities. To correct for database changes, our time-series analysis was applied to both a fixed journal set (same research journals and conference proceedings over time) and a dynamic journal set (changing set of publication outlets). We find that output growth in the 'hospital research orientation' has significantly outpaced the other two application domains, especially since 2006/2007. This happened mainly because of the introduction of new publication outlets in the WoS, but also partially because some universities-especially in China-seem to have become more visible in this domain. Our analytical approach needs further broadening and deepening to provide a more definitive answer whether hospitals and the medical sector are becoming increasingly dominant as a domain of scientific knowledge production and an environment for research applications.

Ion Beam Facility at the University of Chile; Applications and Basic Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Miranda, P. A.; Morales, J. R.; Cancino, S.

2010-08-04

The main characteristics of the ion beam facility based on a 3.75 MeV Van de Graaff accelerator at the University of Chile are described at this work. Current activities are mainly focused on the application of the Ion Beam Analysis techniques for environmental, archaeological, and material science analysis. For instance, Rutherford Backscattering Spectrometry (RBS) is applied to measure thin gold film thickness which are used to determine their resistivity and other electrical properties. At this laboratory the Proton Induced X-Ray Emission (PIXE) and Proton Elastic Scattering Analysis (PESA) methodologies are extensively used for trace element analysis of urban aerosols (Santiago,more » Ciudad de Mexico). A similar study is being carried out at the Antarctica Peninsula. Characterization studies on obsidian and vitreous dacite samples using PIXE has been also perform allowing to match some of these artifacts with geological source sites in Chile.Basic physics research is being carried out by measuring low-energy cross section values for the reactions {sup 63}Cu(d,p){sup 64}Cu and {sup Nat}Zn(p,x){sup 67}Ga. Both radionuclide {sup 64}Cu and {sup 67}Ga are required for applications in medicine. Ongoing stopping power cross section measurements of proton and alphas on Pd, Cu, Bi and Mylar are briefly discussed.« less

Ion Beam Facility at the University of Chile; Applications and Basic Research

NASA Astrophysics Data System (ADS)

Miranda, P. A.; Morales, J. R.; Cancino, S.; Dinator, M. I.; Donoso, N.; Sepúlveda, A.; Ortiz, P.; Rojas, S.

2010-08-01

The main characteristics of the ion beam facility based on a 3.75 MeV Van de Graaff accelerator at the University of Chile are described at this work. Current activities are mainly focused on the application of the Ion Beam Analysis techniques for environmental, archaeological, and material science analysis. For instance, Rutherford Backscattering Spectrometry (RBS) is applied to measure thin gold film thickness which are used to determine their resistivity and other electrical properties. At this laboratory the Proton Induced X-Ray Emission (PIXE) and Proton Elastic Scattering Analysis (PESA) methodologies are extensively used for trace element analysis of urban aerosols (Santiago, Ciudad de Mexico). A similar study is being carried out at the Antarctica Peninsula. Characterization studies on obsidian and vitreous dacite samples using PIXE has been also perform allowing to match some of these artifacts with geological source sites in Chile. Basic physics research is being carried out by measuring low-energy cross section values for the reactions 63Cu(d,p)64Cu and NatZn(p,x)67Ga. Both radionuclide 64Cu and 67Ga are required for applications in medicine. Ongoing stopping power cross section measurements of proton and alphas on Pd, Cu, Bi and Mylar are briefly discussed.

Multilayer scaffolds in orthopaedic tissue engineering.

PubMed

Atesok, Kivanc; Doral, M Nedim; Karlsson, Jon; Egol, Kenneth A; Jazrawi, Laith M; Coelho, Paulo G; Martinez, Amaury; Matsumoto, Tomoyuki; Owens, Brett D; Ochi, Mitsuo; Hurwitz, Shepard R; Atala, Anthony; Fu, Freddie H; Lu, Helen H; Rodeo, Scott A

2016-07-01

The purpose of this study was to summarize the recent developments in the field of tissue engineering as they relate to multilayer scaffold designs in musculoskeletal regeneration. Clinical and basic research studies that highlight the current knowledge and potential future applications of the multilayer scaffolds in orthopaedic tissue engineering were evaluated and the best evidence collected. Studies were divided into three main categories based on tissue types and interfaces for which multilayer scaffolds were used to regenerate: bone, osteochondral junction and tendon-to-bone interfaces. In vitro and in vivo studies indicate that the use of stratified scaffolds composed of multiple layers with distinct compositions for regeneration of distinct tissue types within the same scaffold and anatomic location is feasible. This emerging tissue engineering approach has potential applications in regeneration of bone defects, osteochondral lesions and tendon-to-bone interfaces with successful basic research findings that encourage clinical applications. Present data supporting the advantages of the use of multilayer scaffolds as an emerging strategy in musculoskeletal tissue engineering are promising, however, still limited. Positive impacts of the use of next generation scaffolds in orthopaedic tissue engineering can be expected in terms of decreasing the invasiveness of current grafting techniques used for reconstruction of bone and osteochondral defects, and tendon-to-bone interfaces in near future.

Particle and nuclear physics instrumentation and its broad connections

NASA Astrophysics Data System (ADS)

Demarteau, M.; Lipton, R.; Nicholson, H.; Shipsey, I.

2016-10-01

Subatomic physics shares with other basic sciences the need to innovate, invent, and develop tools, techniques, and technologies to carry out its mission to explore the nature of matter, energy, space, and time. In some cases, entire detectors or technologies developed specifically for particle physics research have been adopted by other fields of research or in commercial applications. In most cases, however, the development of new devices and technologies by particle physics for its own research has added value to other fields of research or to applications beneficial to society by integrating them in the existing technologies. Thus, detector research and development has not only advanced the current state of technology for particle physics, but has often advanced research in other fields of science and has underpinned progress in numerous applications in medicine and national security. At the same time particle physics has profited immensely from developments in industry and applied them to great benefit for the use of particle physics detectors. This symbiotic relationship has seen strong mutual benefits with sometimes unexpected far reach.

On the Edge of Research and Technological Application: A Critical Review of Electromethanogenesis

PubMed Central

Blasco-Gómez, Ramiro; Batlle-Vilanova, Pau; Villano, Marianna; Balaguer, Maria Dolors; Colprim, Jesús; Puig, Sebastià

2017-01-01

The conversion of electrical current into methane (electromethanogenesis) by microbes represents one of the most promising applications of bioelectrochemical systems (BES). Electromethanogenesis provides a novel approach to waste treatment, carbon dioxide fixation and renewable energy storage into a chemically stable compound, such as methane. This has become an important area of research since it was first described, attracting different research groups worldwide. Basics of the process such as microorganisms involved and main reactions are now much better understood, and recent advances in BES configuration and electrode materials in lab-scale enhance the interest in this technology. However, there are still some gaps that need to be filled to move towards its application. Side reactions or scaling-up issues are clearly among the main challenges that need to be overcome to its further development. This review summarizes the recent advances made in the field of electromethanogenesis to address the main future challenges and opportunities of this novel process. In addition, the present fundamental knowledge is critically reviewed and some insights are provided to identify potential niche applications and help researchers to overcome current technological boundaries. PMID:28425974

On the Edge of Research and Technological Application: A Critical Review of Electromethanogenesis.

PubMed

Blasco-Gómez, Ramiro; Batlle-Vilanova, Pau; Villano, Marianna; Balaguer, Maria Dolors; Colprim, Jesús; Puig, Sebastià

2017-04-20

The conversion of electrical current into methane (electromethanogenesis) by microbes represents one of the most promising applications of bioelectrochemical systems (BES). Electromethanogenesis provides a novel approach to waste treatment, carbon dioxide fixation and renewable energy storage into a chemically stable compound, such as methane. This has become an important area of research since it was first described, attracting different research groups worldwide. Basics of the process such as microorganisms involved and main reactions are now much better understood, and recent advances in BES configuration and electrode materials in lab-scale enhance the interest in this technology. However, there are still some gaps that need to be filled to move towards its application. Side reactions or scaling-up issues are clearly among the main challenges that need to be overcome to its further development. This review summarizes the recent advances made in the field of electromethanogenesis to address the main future challenges and opportunities of this novel process. In addition, the present fundamental knowledge is critically reviewed and some insights are provided to identify potential niche applications and help researchers to overcome current technological boundaries.

Is the use of sentient animals in basic research justifiable?

PubMed Central

2010-01-01

Animals can be used in many ways in science and scientific research. Given that society values sentient animals and that basic research is not goal oriented, the question is raised: "Is the use of sentient animals in basic research justifiable?" We explore this in the context of funding issues, outcomes from basic research, and the position of society as a whole on using sentient animals in research that is not goal oriented. We conclude that the use of sentient animals in basic research cannot be justified in light of society's priorities. PMID:20825676

Is the use of sentient animals in basic research justifiable?

PubMed

Greek, Ray; Greek, Jean

2010-09-08

Animals can be used in many ways in science and scientific research. Given that society values sentient animals and that basic research is not goal oriented, the question is raised: "Is the use of sentient animals in basic research justifiable?" We explore this in the context of funding issues, outcomes from basic research, and the position of society as a whole on using sentient animals in research that is not goal oriented. We conclude that the use of sentient animals in basic research cannot be justified in light of society's priorities.

Informatics Support for Basic Research in Biomedicine

PubMed Central

Rindflesch, Thomas C.; Blake, Catherine L.; Fiszman, Marcelo; Kilicoglu, Halil; Rosemblat, Graciela; Schneider, Jodi; Zeiss, Caroline J.

2017-01-01

Abstract Informatics methodologies exploit computer-assisted techniques to help biomedical researchers manage large amounts of information. In this paper, we focus on the biomedical research literature (MEDLINE). We first provide an overview of some text mining techniques that offer assistance in research by identifying biomedical entities (e.g., genes, substances, and diseases) and relations between them in text. We then discuss Semantic MEDLINE, an application that integrates PubMed document retrieval, concept and relation identification, and visualization, thus enabling a user to explore concepts and relations from within a set of retrieved citations. Semantic MEDLINE provides a roadmap through content and helps users discern patterns in large numbers of retrieved citations. We illustrate its use with an informatics method we call “discovery browsing,” which provides a principled way of navigating through selected aspects of some biomedical research area. The method supports an iterative process that accommodates learning and hypothesis formation in which a user is provided with high level connections before delving into details. As a use case, we examine current developments in basic research on mechanisms of Alzheimer’s disease. Out of the nearly 90 000 citations returned by the PubMed query “Alzheimer’s disease,” discovery browsing led us to 73 citations on sortilin and that disorder. We provide a synopsis of the basic research reported in 15 of these. There is wide-spread consensus among researchers working with a range of animal models and human cells that increased sortilin expression and decreased receptor expression are associated with amyloid beta and/or amyloid precursor protein. PMID:28838071

Electrospun Polymer Fibers for Electronic Applications

PubMed Central

Luzio, Alessandro; Canesi, Eleonora Valeria; Bertarelli, Chiara; Caironi, Mario

2014-01-01

Nano- and micro- fibers of conjugated polymer semiconductors are particularly interesting both for applications and for fundamental research. They allow an investigation into how electronic properties are influenced by size confinement and chain orientation within microstructures that are not readily accessible within thin films. Moreover, they open the way to many applications in organic electronics, optoelectronics and sensing. Electro-spinning, the technique subject of this review, is a simple method to effectively form and control conjugated polymer fibers. We provide the basics of the technique and its recent advancements for the formation of highly conducting and high mobility polymer fibers towards their adoption in electronic applications. PMID:28788493

Introduction to metabolomics and its applications in ophthalmology

PubMed Central

Tan, S Z; Begley, P; Mullard, G; Hollywood, K A; Bishop, P N

2016-01-01

Metabolomics is the study of endogenous and exogenous metabolites in biological systems, which aims to provide comparative semi-quantitative information about all metabolites in the system. Metabolomics is an emerging and potentially powerful tool in ophthalmology research. It is therefore important for health professionals and researchers involved in the speciality to understand the basic principles of metabolomics experiments. This article provides an overview of the experimental workflow and examples of its use in ophthalmology research from the study of disease metabolism and pathogenesis to identification of biomarkers. PMID:26987591

Software Engineering Laboratory (SEL) relationships, models, and management rules

NASA Technical Reports Server (NTRS)

Decker, William; Hendrick, Robert; Valett, Jon D.

1991-01-01

Over 50 individual Software Engineering Laboratory (SEL) research results, extracted from a review of published SEL documentation, that can be applied directly to managing software development projects are captured. Four basic categories of results are defined and discussed - environment profiles, relationships, models, and management rules. In each category, research results are presented as a single page that summarizes the individual result, lists potential uses of the result by managers, and references the original SEL documentation where the result was found. The document serves as a concise reference summary of applicable research for SEL managers.

Molecular mechanism-based model to enhance outcomes of dietary intervention studies for disease prevention

PubMed Central

Dey, Moul

2014-01-01

Advances in “omics”-based fields have produced an explosion of new information, fueling high expectations for improved public and individualized health. Unfortunately, there exists a widening gap between basic biochemistry and “omics”-based population research, with both disciplines failing to translate their full potential impact to human health applications. A paucity of comprehensive study systems is one of the many roadblocks faced by translational research today. This commentary will highlight the current status of such research, particularly emphasizing the role of nutrigenomics. PMID:25364700

Fuzzy logic

NASA Technical Reports Server (NTRS)

Zadeh, Lofti A.

1988-01-01

The author presents a condensed exposition of some basic ideas underlying fuzzy logic and describes some representative applications. The discussion covers basic principles; meaning representation and inference; basic rules of inference; and the linguistic variable and its application to fuzzy control.

Translational progress on tumor biomarkers

PubMed Central

Guo, Hongwei; Zhou, Xiaolin; Lu, Yi; Xie, Liye; Chen, Qian; Keller, Evan T; Liu, Qian; Zhou, Qinghua; Zhang, Jian

2015-01-01

There is an urgent need to apply basic research achievements to the clinic. In particular, mechanistic studies should be developed by bench researchers, depending upon clinical demands, in order to improve the survival and quality of life of cancer patients. To date, translational medicine has been addressed in cancer biology, particularly in the identification and characterization of novel tumor biomarkers. This review focuses on the recent achievements and clinical application prospects in tumor biomarkers based on translational medicine. PMID:26557902

Biobased Carbon Fibers and Thermosetting Resins for Use in DoD Composites Applications

DTIC Science & Technology

2017-03-01

organizations. SERDP invests across a broad spectrum of basic and applied research , as well as advanced development. SERDP focuses on cross-service...carbonization steps. To avoid the use of solvents, prior research has focused on the development of carbon fibers from melt- spinnable PAN precursor...bacteria. In this study , the goal is to find organisms that can break one or more of the different linkages in lignin. A bacterium will not

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Research is organized around two major programs: thermal and aquatic stress and mineral cycling. These programs are strengthened by a previously established foundation of basic ecological knowledge. Research in basic ecology continues to be a major component of all SREL environmental programs. Emphasis in all programs has been placed upon field-oriented research relating to regional and local problems having broad ecological significance. For example, extensive research has been conducted in the Par Pond reservoir system and the Savannah River swamp, both of which have received thermal effluent, heavy metals, and low levels of radioisotopes. Furthermore, the availability of low levelsmore » of plutonium and uranium in both terrestrial and aquatic environments on the Savannah River Plant (SRP) has provided an unusual opportunity for field research in this area. The studies seek to document the effects, to determine the extent of local environmental problems, and to establish predictable relationships which have general applicability. In order to accomplish this objective it has been imperative that studies be carried out in the natural, environmentally unaffected areas on the SRP as a vital part of the overall program. Progress is reported in forty-nine studies.« less

Boehringer Mannheim award lecture 1995. La conference Boehringer Mannheim 1995. De novo design of alpha-helical proteins: basic research to medical applications.

PubMed

Hodges, R S

1996-01-01

The two-stranded alpha-helical coiled-coil is a universal dimerization domain used by nature in a diverse group of proteins. The simplicity of the coiled-coil structure makes it an ideal model system to use in understanding the fundamentals of protein folding and stability and in testing the principles of de novo design. The issues that must be addressed in the de novo design of coiled-coils for use in research and medical applications are (i) controlling parallel versus antiparallel orientation of the polypeptide chains, (ii) controlling the number of helical strands in the assembly (iii) maximizing stability of homodimers or heterodimers in the shortest possible chain length that may require the engineering of covalent constraints, and (iv) the ability to have selective heterodimerization without homodimerization, which requires a balancing of selectivity versus affinity of the dimerization strands. Examples of our initial inroads in using this de novo design motif in various applications include: heterodimer technology for the detection and purification of recombinant peptides and proteins; a universal dimerization domain for biosensors; a two-stage targeting and delivery system; and coiled-coils as templates for combinatorial helical libraries for basic research and drug discovery and as synthetic carrier molecules. The universality of this dimerization motif in nature suggests an endless number of possibilities for its use in de novo design, limited only by the creativity of peptide-protein engineers.

[Recent researching progress of Lepidium meyenii (Maca)].

PubMed

Zhou, Yan-yan; Zhao, Hai-yu; Si, Nan; Wang, Hong-jie; Gian, Bao-lin

2015-12-01

Maca as one of the star products in the international health care market in recent years, had a wide range of application value and promoted to all over the world. However, the basic research of Maca was not deep, lack of systematic and clear efficacy studies. Market products hype its aphrodisiac effect, which greatly impact more systematic in-depth research and exploration. Therefore, this paper briefly summarizes advance research in recent years including the status quo of the resources, growth cultivation, phytochemical, pharmacological effect and other aspects, which can provide reference for rational development and utilization of Maca.

Training Under-Represented Students in Biological Research at Fisk University

NASA Technical Reports Server (NTRS)

Gunasekaran, Muthukumaran

1999-01-01

The objectives of our training and research project in biology at Fisk are to motivate and train our African-American undergraduate and graduate students by (a) teaching the basic principles and applications of different biological, biochemical and biophysical research techniques; (b) providing a "hands on experience" with laboratory instrumentation (c) requiring the students to participate in the proposed research project entitled "Cyanobacterial Bioreactors for Oxygen and Ammonia Production under "CELSS" Conditions" to gain confidence in independently conducting experiments and (d) providing training in scientific data collection and presentation to peers in scientific conferences or meetings.

Photovoltaic Research in the Small Business Innovative Research Program

NASA Astrophysics Data System (ADS)

Bower, Ward I.; Bulawka, Alec

1997-02-01

The Small Business Innovative Research Program (SBIR) is currently authorized to be funded through September 30, 2000. The National Photovoltaics Program is a contributor to the Department of Energy (DOE) SBIR program. The small business photovoltaic industry has been benefiting from the SBIR program through awards that have funded basic research, new processes and products that have PV and other commercial applications. This paper provides information on SBIR opportunities, selected details of the SBIR program, statistics from the 1995 and 1996 DOE SBIR program, and methods for improving PV industry participation and success in the SBIR program.

Current Status of Sperm Cryopreservation in Biomedical Research Fish Models: Zebrafish, Medaka, and Xiphophorus*

PubMed Central

Yang, Huiping; Tiersch, Terrence R.

2009-01-01

Aquarium fishes are becoming increasingly important because of their value in biomedical research and the ornamental fish trade, and because many have become threatened or endangered in the wild. This review summarizes the current status of sperm cryopreservation in three fishes widely used in biomedical research: zebrafish, medaka, and live-bearing fishes of the genus Xiphophorus, and will focus on the needs and opportunities for future research and application of cryopreservation in aquarium fish. First, we summarize the basic biological characteristics regarding natural habitat, testis structure, spermatogenesis, sperm morphology, and sperm physiology. Second, we compare protocol development of sperm cryopreservation. Third, we emphasize the importance of artificial fertilization in sperm cryopreservation to evaluate the viability of thawed sperm. We conclude with a look to future research directions for sperm cryopreservation and the application of this technique in aquarium species. PMID:18691673

A system-level approach to automation research

NASA Technical Reports Server (NTRS)

Harrison, F. W.; Orlando, N. E.

1984-01-01

Automation is the application of self-regulating mechanical and electronic devices to processes that can be accomplished with the human organs of perception, decision, and actuation. The successful application of automation to a system process should reduce man/system interaction and the perceived complexity of the system, or should increase affordability, productivity, quality control, and safety. The expense, time constraints, and risk factors associated with extravehicular activities have led the Automation Technology Branch (ATB), as part of the NASA Automation Research and Technology Program, to investigate the use of robots and teleoperators as automation aids in the context of space operations. The ATB program addresses three major areas: (1) basic research in autonomous operations, (2) human factors research on man-machine interfaces with remote systems, and (3) the integration and analysis of automated systems. This paper reviews the current ATB research in the area of robotics and teleoperators.

[Preliminarily application of content analysis to qualitative nursing data].

PubMed

Liang, Shu-Yuan; Chuang, Yeu-Hui; Wu, Shu-Fang

2012-10-01

Content analysis is a methodology for objectively and systematically studying the content of communication in various formats. Content analysis in nursing research and nursing education is called qualitative content analysis. Qualitative content analysis is frequently applied to nursing research, as it allows researchers to determine categories inductively and deductively. This article examines qualitative content analysis in nursing research from theoretical and practical perspectives. We first describe how content analysis concepts such as unit of analysis, meaning unit, code, category, and theme are used. Next, we describe the basic steps involved in using content analysis, including data preparation, data familiarization, analysis unit identification, creating tentative coding categories, category refinement, and establishing category integrity. Finally, this paper introduces the concept of content analysis rigor, including dependability, confirmability, credibility, and transferability. This article elucidates the content analysis method in order to help professionals conduct systematic research that generates data that are informative and useful in practical application.

[Analysis of the application and funding projects of National Natural Science Foundation of China in the field of burns and plastic surgery from 2010 to 2016].

PubMed

Zhang, Z C; Dou, D; Wang, X Y; Xie, D H; Yan, Z C

2017-02-20

We analyzed the data of application and funding projects of the National Natural Science Foundation of China (NSFC) during 2010-2016 in the field of burns and plastic surgery and summarized the NSFC funding pattern, the research hotspots, and weaknesses in this field. The NSFC has funded 460 projects in the field of burns and plastic surgery, with total funding of RMB 227.96 million. The scientific issues involved in the funding projects include orthotherapy against malformations, wound repair, basic research of burns, skin grafting, scars prevention, and regeneration of hair follicle and sweat glands. The research techniques involved in the funding projects are diversified. NSFC plays an important role in the scientific research and talents training in the field of burns and plastic surgery.

Antimicrobial Photodynamic Inactivation and Antitumor Photodynamic Therapy with Fullerenes

NASA Astrophysics Data System (ADS)

de Freitas, Lucas F.

2016-04-01

This book provides detailed and current information on using fullerenes (bucky-balls) in photodynamic therapy (PDT), one of the most actively studied applications of photonic science in healthcare. This will serve as a useful source for researchers working in photomedicine and nanomedicine, especially those who are investigating PDT for cancer treatment and infectious disease treatment. The book runs the gamut from an introduction to the history and chemistry of fullerenes and some basic photochemistry, to the application of fullerenes as photosensitizers for cancer and antimicrobial inactivation.

Application of reverse osmosis in purifying drinking water

NASA Astrophysics Data System (ADS)

Jiang, Lei; Tu, Yue; Li, Xiangmin; Li, Haixiang

2018-06-01

In view of the shortage of water resources and the pollution of water environment, the development of efficient water purification technology is one of the effective ways to ensure the safety of drinking water. The technology of reverse osmosis has attracted much attention in the application of drinking water security for its advantages of no phase change and simple equipment. This paper briefly introduces the research progress at home and abroad, basic principles, process flow diagram, advantages and disadvantages and development direction of the technology.

Impact of research investment on scientific productivity of junior researchers.

PubMed

Farrokhyar, Forough; Bianco, Daniela; Dao, Dyda; Ghert, Michelle; Andruszkiewicz, Nicole; Sussman, Jonathan; Ginsberg, Jeffrey S

2016-12-01

There is a demand for providing evidence on the effectiveness of research investments on the promotion of novice researchers' scientific productivity and production of research with new initiatives and innovations. We used a mixed method approach to evaluate the funding effect of the New Investigator Fund (NIF) by comparing scientific productivity between award recipients and non-recipients. We reviewed NIF grant applications submitted from 2004 to 2013. Scientific productivity was assessed by confirming the publication of the NIF-submitted application. Online databases were searched, independently and in duplicate, to locate the publications. Applicants' perceptions and experiences were collected through a short survey and categorized into specified themes. Multivariable logistic regression was performed. Odds ratios (OR) with 95 % confidence intervals (CI) are reported. Of 296 applicants, 163 (55 %) were awarded. Gender, affiliation, and field of expertise did not affect funding decisions. More physicians with graduate education (32.0 %) and applicants with a doctorate degree (21.5 %) were awarded than applicants without postgraduate education (9.8 %). Basic science research (28.8 %), randomized controlled trials (24.5 %), and feasibility/pilot trials (13.3 %) were awarded more than observational designs (p   <  0.001). Adjusting for applicants and application factors, awardees published the NIF application threefold more than non-awardees (OR = 3.4, 95 %, CI = 1.9, 5.9). The survey response rate was 90.5 %, and only 58 % commented on their perceptions, successes, and challenges of the submission process. These findings suggest that research investments as small as seed funding are effective for scientific productivity and professional growth of novice investigators and production of research with new initiatives and innovations. Further efforts are recommended to enhance the support of small grant funding programs.

The road for nanomaterials industry: a review of carbon nanotube production, post-treatment, and bulk applications for composites and energy storage.

PubMed

Zhang, Qiang; Huang, Jia-Qi; Qian, Wei-Zhong; Zhang, Ying-Ying; Wei, Fei

2013-04-22

The innovation on the low dimensional nanomaterials brings the rapid growth of nano community. Developing the controllable production and commercial applications of nanomaterials for sustainable society is highly concerned. Herein, carbon nanotubes (CNTs) with sp(2) carbon bonding, excellent mechanical, electrical, thermal, as well as transport properties are selected as model nanomaterials to demonstrate the road of nanomaterials towards industry. The engineering principles of the mass production and recent progress in the area of CNT purification and dispersion are described, as well as its bulk application for nanocomposites and energy storage. The environmental, health, and safety considerations of CNTs, and recent progress in CNT commercialization are also included. With the effort from the CNT industry during the past 10 years, the price of multi-walled CNTs have decreased from 45 000 to 100 $ kg(-1) and the productivity increased to several hundred tons per year for commercial applications in Li ion battery and nanocomposites. When the prices of CNTs decrease to 10 $ kg(-1) , their applications as composites and conductive fillers at a million ton scale can be anticipated, replacing conventional carbon black fillers. Compared with traditional bulk chemicals, the controllable synthesis and applications of CNTs on a million ton scale are still far from being achieved due to the challenges in production, purification, dispersion, and commercial application. The basic knowledge of growth mechanisms, efficient and controllable routes for CNT production, the environmental and safety issues, and the commercialization models are still inadequate. The gap between the basic scientific research and industrial development should be bridged by multidisciplinary research for the rapid growth of CNT nano-industry. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

GSTARS computer models and their applications, Part II: Applications

USGS Publications Warehouse

Simoes, F.J.M.; Yang, C.T.

2008-01-01

In part 1 of this two-paper series, a brief summary of the basic concepts and theories used in developing the Generalized Stream Tube model for Alluvial River Simulation (GSTARS) computer models was presented. Part 2 provides examples that illustrate some of the capabilities of the GSTARS models and how they can be applied to solve a wide range of river and reservoir sedimentation problems. Laboratory and field case studies are used and the examples show representative applications of the earlier and of the more recent versions of GSTARS. Some of the more recent capabilities implemented in GSTARS3, one of the latest versions of the series, are also discussed here with more detail. ?? 2008 International Research and Training Centre on Erosion and Sedimentation and the World Association for Sedimentation and Erosion Research.

Cellular Therapies Clinical Research Roadmap: lessons learned on how to move a cellular therapy into a clinical trial.

PubMed

Ouseph, Stacy; Tappitake, Darah; Armant, Myriam; Wesselschmidt, Robin; Derecho, Ivy; Draxler, Rebecca; Wood, Deborah; Centanni, John M

2015-04-01

A clinical research roadmap has been developed as a resource for researchers to identify critical areas and potential pitfalls when transitioning a cellular therapy product from the research laboratory, by means of an Investigational New Drug (IND) application, into early-phase clinical trials. The roadmap describes four key areas: basic and preclinical research, resource development, translational research and Good Manufacturing Practice (GMP) and IND assembly and submission. Basic and preclinical research identifies a new therapeutic concept and demonstrates its potential value with the use of a model of the relevant disease. During resource development, the appropriate specialists and the required expertise to bring this product into the clinic are identified (eg, researchers, regulatory specialists, GMP manufacturing staff, clinicians and clinical trials staff, etc). Additionally, the funds required to achieve this goal (or a plan to procure them) are identified. In the next phase, the plan to translate the research product into a clinical-grade therapeutic is developed. Finally regulatory approval to start the trial must be obtained. In the United States, this is done by filing an IND application with the Food and Drug Administration. The National Heart, Lung and Blood Institute-funded Production Assistance for Cellular Therapies program has facilitated the transition of a variety of cellular therapy products from the laboratory into Phase1/2 trials. The five Production Assistance for Cellular Therapies facilities have assisted investigators by performing translational studies and GMP manufacturing to ensure that cellular products met release specifications and were manufactured safely, reproducibly and at the appropriate scale. The roadmap resulting from this experience is the focus of this article. Copyright © 2015 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Transputer parallel processing at NASA Lewis Research Center

NASA Technical Reports Server (NTRS)

Ellis, Graham K.

1989-01-01

The transputer parallel processing lab at NASA Lewis Research Center (LeRC) consists of 69 processors (transputers) that can be connected into various networks for use in general purpose concurrent processing applications. The main goal of the lab is to develop concurrent scientific and engineering application programs that will take advantage of the computational speed increases available on a parallel processor over the traditional sequential processor. Current research involves the development of basic programming tools. These tools will help standardize program interfaces to specific hardware by providing a set of common libraries for applications programmers. The thrust of the current effort is in developing a set of tools for graphics rendering/animation. The applications programmer currently has two options for on-screen plotting. One option can be used for static graphics displays and the other can be used for animated motion. The option for static display involves the use of 2-D graphics primitives that can be called from within an application program. These routines perform the standard 2-D geometric graphics operations in real-coordinate space as well as allowing multiple windows on a single screen.

Harnessing neuroplasticity for clinical applications

PubMed Central

Sur, Mriganka; Dobkin, Bruce H.; O'Brien, Charles; Sanger, Terence D.; Trojanowski, John Q.; Rumsey, Judith M.; Hicks, Ramona; Cameron, Judy; Chen, Daofen; Chen, Wen G.; Cohen, Leonardo G.; deCharms, Christopher; Duffy, Charles J.; Eden, Guinevere F.; Fetz, Eberhard E.; Filart, Rosemarie; Freund, Michelle; Grant, Steven J.; Haber, Suzanne; Kalivas, Peter W.; Kolb, Bryan; Kramer, Arthur F.; Lynch, Minda; Mayberg, Helen S.; McQuillen, Patrick S.; Nitkin, Ralph; Pascual-Leone, Alvaro; Reuter-Lorenz, Patricia; Schiff, Nicholas; Sharma, Anu; Shekim, Lana; Stryker, Michael; Sullivan, Edith V.; Vinogradov, Sophia

2011-01-01

Neuroplasticity can be defined as the ability of the nervous system to respond to intrinsic or extrinsic stimuli by reorganizing its structure, function and connections. Major advances in the understanding of neuroplasticity have to date yielded few established interventions. To advance the translation of neuroplasticity research towards clinical applications, the National Institutes of Health Blueprint for Neuroscience Research sponsored a workshop in 2009. Basic and clinical researchers in disciplines from central nervous system injury/stroke, mental/addictive disorders, paediatric/developmental disorders and neurodegeneration/ageing identified cardinal examples of neuroplasticity, underlying mechanisms, therapeutic implications and common denominators. Promising therapies that may enhance training-induced cognitive and motor learning, such as brain stimulation and neuropharmacological interventions, were identified, along with questions of how best to use this body of information to reduce human disability. Improved understanding of adaptive mechanisms at every level, from molecules to synapses, to networks, to behaviour, can be gained from iterative collaborations between basic and clinical researchers. Lessons can be gleaned from studying fields related to plasticity, such as development, critical periods, learning and response to disease. Improved means of assessing neuroplasticity in humans, including biomarkers for predicting and monitoring treatment response, are needed. Neuroplasticity occurs with many variations, in many forms, and in many contexts. However, common themes in plasticity that emerge across diverse central nervous system conditions include experience dependence, time sensitivity and the importance of motivation and attention. Integration of information across disciplines should enhance opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies. PMID:21482550

REVIEWS OF TOPICAL PROBLEMS: Application of cybernetic methods in physics

NASA Astrophysics Data System (ADS)

Fradkov, Aleksandr L.

2005-02-01

Basic aspects of the subject and methodology for a new and rapidly developing area of research that has emerged at the intersection of physics and control theory (cybernetics) and emphasizes the application of cybernetic methods to the study of physical systems are reviewed. Speed-gradient and Hamiltonian solutions for energy control problems in conservative and dissipative systems are presented. Application examples such as the Kapitza pendulum, controlled overcoming of a potential barrier, and controlling coupled oscillators and molecular systems are presented. A speed-gradient approach to modeling the dynamics of physical systems is discussed.

Behavioural science at work for Canada: National Research Council laboratories.

PubMed

Veitch, Jennifer A

2007-03-01

The National Research Council is Canada's principal research and development agency. Its 20 institutes are structured to address interdisciplinary problems for industrial sectors, and to provide the necessary scientific infrastructure, such as the national science library. Behavioural scientists are active in five institutes: Biological Sciences, Biodiagnostics, Aerospace, Information Technology, and Construction. Research topics include basic cellular neuroscience, brain function, human factors in the cockpit, human-computer interaction, emergency evacuation, and indoor environment effects on occupants. Working in collaboration with NRC colleagues and with researchers from universities and industry, NRC behavioural scientists develop knowledge, designs, and applications that put technology to work for people, designed with people in mind.

Genome sequence of Clostridium tunisiense TJ, isolated from drain sediment from a pesticide factory.

PubMed

Sun, Lili; Wang, Yu; Yu, Chunyan; Zhao, Yongqin; Gan, Yinbo

2012-12-01

Clostridium tunisiense is a Gram-positive, obligate anaerobe that was first isolated in an anaerobic environment under eutrophication. Here we report the first genome sequence of the Clostridium tunisiense TJ isolated from drain sediment of a pesticide factory in Tianjin, China. The genome is of great importance for both basic and application research.

Differential Reinforcement of Alternative Behavior Increases Resistance to Extinction: Clinical Demonstration, Animal Modeling, and Clinical Test of One Solution

ERIC Educational Resources Information Center

Mace, F. Charles; McComas, Jennifer J.; Mauro, Benjamin C.; Progar, Patrick R.; Taylor, Bridget; Ervin, Ruth; Zangrillo, Amanda N.

2010-01-01

Basic research with pigeons on behavioral momentum suggests that differential reinforcement of alternative behavior (DRA) can increase the resistance of target behavior to change. This finding suggests that clinical applications of DRA may inadvertently increase the persistence of target behavior even as it decreases its frequency. We conducted…

Hubble Space Telescope cycle 5 call for proposals

NASA Technical Reports Server (NTRS)

Bond, Howard E. (Editor)

1994-01-01

This document invites and supports participation by the international astronomical community in the HST General Observer and Archival Research programs. These documents contain the basic procedural and technical information required for HST proposal preparation and submission, including applicable deadlines. The telescope and its instruments were built under the auspices of the NASA and the European Space Agency.

Community Satisfaction: Implications for Army Communities

DTIC Science & Technology

1990-08-01

1954) hierarchical theory of motivation, hypothesize that a hierarchy of community services exists, such that basic human needs must be provided for...help in an emergency (Ahlbrandt, 1984). Neighbors 13 may provide socioemotional support, which is positively associated with neighborhood satisfaction...Saroson & B. R. Sarason (Eds.), Social .support: Theory , research and applications. Boston: Martinus Nijhoff. Baldassare, M. (1979). Residential crowding

Proceedings of the Speech Communication Association Summer Conference: Mini Courses in Speech Communication (7th, Chicago, July 8-10, 1971).

ERIC Educational Resources Information Center

Jeffrey, Robert C., Ed.

The Speech Communication Association's 1971 summer conference provided instruction in the application of basic research and innovative practices in communication. It was designed to assist elementary, secondary, and college teachers in the enrichment of content and procedures. The proceedings include syllabi, course units, and bibliographic…

An overview of computer vision

NASA Technical Reports Server (NTRS)

Gevarter, W. B.

1982-01-01

An overview of computer vision is provided. Image understanding and scene analysis are emphasized, and pertinent aspects of pattern recognition are treated. The basic approach to computer vision systems, the techniques utilized, applications, the current existing systems and state-of-the-art issues and research requirements, who is doing it and who is funding it, and future trends and expectations are reviewed.

Computer Systems for Urban School Administrators: A Guide for Decision Making. ERIC/CUE Urban Diversity Series, Number 78.

ERIC Educational Resources Information Center

Vigilante, Richard P.

This monograph introduces educational administrators at a variety of levels to the basic concepts and procedures in the successful implementation of educational computer systems. In the first section, the units and functions of the computer are defined, and the administrative, research, and instructional applications of educational computing are…

The Perception of Time: Basic Research and Some Potential Links to the Study of Language

ERIC Educational Resources Information Center

Wearden, J. H.

2008-01-01

The article first discusses some recent work in time perception--in particular the distinction among prospective timing, retrospective timing, and passage of time judgments. The history and application of an "internal clock" model as an explanation of prospective timing performance is reviewed and contrasted with the different mechanisms needed…

Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells.

PubMed

Hong, So Gun; Dunbar, Cynthia E; Winkler, Thomas

2013-02-01

Induced pluripotent stem cells (iPSCs) have great potential for regenerative medicine as well as for basic and translational research. However, following the initial excitement over the enormous prospects of this technology, several reports uncovered serious concerns regarding its safety for clinical applications and reproducibility for laboratory applications such as disease modeling or drug screening. In particular, the genomic integrity of iPSCs is the focus of extensive research. Epigenetic remodeling, aberrant expression of reprogramming factors, clonal selection, and prolonged in vitro culture are potential pathways for acquiring genomic alterations. In this review, we will critically discuss current reprogramming technologies particularly in the context of genotoxicity, and the consequences of these alternations for the potential applications of reprogrammed cells. In addition, current strategies of genetic modification of iPSCs, as well as applicable suicide strategies to control the risk of iPSC-based therapies will be introduced.

Medical Applications of Synchrotron Radiation

DOE R&D Accomplishments Database

Thomlinson, W.

1991-10-01

Ever since the first diagnostic x-ray was done in the United States on February 3, 1896, the application of ionizing radiation to the field of medicine has become increasingly important. Both in clinical medicine and basic research the use of x-rays for diagnostic imaging and radiotherapy is now widespread. Radiography, angiography, CAT and PETT scanning, mammography, and nuclear medicine are all examples of technologies developed to image the human anatomy. In therapeutic applications, both external and internal sources of radiation are applied to the battle against cancer. The development of dedicated synchrotron radiation sources has allowed exciting advances to take place in many of these applications. The new sources provide tunable, high-intensity monochromatic beams over a wide range of energies which can be tailored to specific programmatic needs. This paper surveys those areas of medical research in which synchrotron radiation facilities are actively involved.

Emerging technology: applications of Raman spectroscopy for prostate cancer.

PubMed

Kast, Rachel E; Tucker, Stephanie C; Killian, Kevin; Trexler, Micaela; Honn, Kenneth V; Auner, Gregory W

2014-09-01

There is a need in prostate cancer diagnostics and research for a label-free imaging methodology that is nondestructive, rapid, objective, and uninfluenced by water. Raman spectroscopy provides a molecular signature, which can be scaled from micron-level regions of interest in cells to macroscopic areas of tissue. It can be used for applications ranging from in vivo or in vitro diagnostics to basic science laboratory testing. This work describes the fundamentals of Raman spectroscopy and complementary techniques including surface enhanced Raman scattering, resonance Raman spectroscopy, coherent anti-Stokes Raman spectroscopy, confocal Raman spectroscopy, stimulated Raman scattering, and spatially offset Raman spectroscopy. Clinical applications of Raman spectroscopy to prostate cancer will be discussed, including screening, biopsy, margin assessment, and monitoring of treatment efficacy. Laboratory applications including cell identification, culture monitoring, therapeutics development, and live imaging of cellular processes are discussed. Potential future avenues of research are described, with emphasis on multiplexing Raman spectroscopy with other modalities.

Life sciences and environmental sciences

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-02-01

The DOE laboratories play a unique role in bringing multidisciplinary talents -- in biology, physics, chemistry, computer sciences, and engineering -- to bear on major problems in the life and environmental sciences. Specifically, the laboratories utilize these talents to fulfill OHER's mission of exploring and mitigating the health and environmental effects of energy use, and of developing health and medical applications of nuclear energy-related phenomena. At Lawrence Berkeley Laboratory (LBL) support of this mission is evident across the spectrum of OHER-sponsored research, especially in the broad areas of genomics, structural biology, basic cell and molecular biology, carcinogenesis, energy and environment,more » applications to biotechnology, and molecular, nuclear and radiation medicine. These research areas are briefly described.« less

Research progress about chemical energy storage of solar energy

NASA Astrophysics Data System (ADS)

Wu, Haifeng; Xie, Gengxin; Jie, Zheng; Hui, Xiong; Yang, Duan; Du, Chaojun

2018-01-01

In recent years, the application of solar energy has been shown obvious advantages. Solar energy is being discontinuity and inhomogeneity, so energy storage technology becomes the key to the popularization and utilization of solar energy. Chemical storage is the most efficient way to store and transport solar energy. In the first and the second section of this paper, we discuss two aspects about the solar energy collector / reactor, and solar energy storage technology by hydrogen production, respectively. The third section describes the basic application of solar energy storage system, and proposes an association system by combining solar energy storage and power equipment. The fourth section briefly describes several research directions which need to be strengthened.

Particle and nuclear physics instrumentation and its broad connections

DOE PAGES

Demarteau, Marcel; Lipton, Ron; Nicholson, Howard; ...

2016-12-20

Subatomic physics shares with other basic sciences the need to innovate, invent, and develop tools, techniques, and technologies to carry out its mission to explore the nature of matter, energy, space, and time. In some cases, entire detectors or technologies developed specifically for particle physics research have been adopted by other fields of research or in commercial applications. In most cases, however, the development of new devices and technologies by particle physics for its own research has added value to other fields of research or to applications beneficial to society by integrating them in the existing technologies. Thus, detector researchmore » and development has not only advanced the current state of technology for particle physics, but has often advanced research in other fields of science and has underpinned progress in numerous applications in medicine and national security. At the same time particle physics has profited immensely from developments in industry and applied them to great benefit for the use of particle physics detectors. Finally, this symbiotic relationship has seen strong mutual benefits with sometimes unexpected far reach.« less

Particle and nuclear physics instrumentation and its broad connections

DOE Office of Scientific and Technical Information (OSTI.GOV)

Demarteau, Marcel; Lipton, Ron; Nicholson, Howard

Subatomic physics shares with other basic sciences the need to innovate, invent, and develop tools, techniques, and technologies to carry out its mission to explore the nature of matter, energy, space, and time. In some cases, entire detectors or technologies developed specifically for particle physics research have been adopted by other fields of research or in commercial applications. In most cases, however, the development of new devices and technologies by particle physics for its own research has added value to other fields of research or to applications beneficial to society by integrating them in the existing technologies. Thus, detector researchmore » and development has not only advanced the current state of technology for particle physics, but has often advanced research in other fields of science and has underpinned progress in numerous applications in medicine and national security. At the same time particle physics has profited immensely from developments in industry and applied them to great benefit for the use of particle physics detectors. Finally, this symbiotic relationship has seen strong mutual benefits with sometimes unexpected far reach.« less

32 CFR Appendix C to Part 110 - Application of Basic Course Formula (Male and Female Members) (Sample)

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 1 2011-07-01 2011-07-01 false Application of Basic Course Formula (Male and Female Members) (Sample) C Appendix C to Part 110 National Defense Department of Defense OFFICE OF THE... Appendix C to Part 110—Application of Basic Course Formula (Male and Female Members) (Sample) Zone I Zone...

The full translational spectrum of prevention science: facilitating the transfer of knowledge to practices and policies that prevent behavioral health problems.

PubMed

Fishbein, Diana H; Ridenour, Ty A; Stahl, Mindy; Sussman, Steve

2016-03-01

A broad-span, six-stage translational prevention model is presented, extending from the basic sciences-taking a multi-level systems approach, including the neurobiological sciences-through to globalization. The application of a very wide perspective of translation research from basic scientific discovery to international policy change promises to elicit sustainable, population-level reductions in behavioral health disorders. To illustrate the conceptualization and actualization of a program of translational prevention research, we walk through each stage of research to practice and policy using an exemplar, callous-unemotional (CU) traits. Basic science has identified neurobiological, psychophysiological, behavioral, contextual, and experiential differences in this subgroup, and yet, these findings have not been applied to the development of more targeted intervention. As a result, there are currently no programs considered especially effective for CU traits, likely because they do not specifically target underlying mechanisms. To prevent/reduce the prevalence of conduct disorder, it is critical that we transfer existing knowledge to subsequent translational stages, including intervention development, implementation, and scaling. And eventually, once resulting programs have been rigorously evaluated, replicated, and adapted across cultural, ethnic, and gender groups, there is potential to institutionalize them as well as call attention to the special needs of this population. In this paper, we begin to consider what resources and changes in research perspectives are needed to move along this translational spectrum.

[Nuclear transfer and therapeutic cloning].

PubMed

Xu, Xiao-Ming; Lei, An-Min; Hua, Jin-Lian; Dou, Zhong-Ying

2005-03-01

Nuclear transfer and therapeutic cloning have widespread and attractive prospects in animal agriculture and biomedical applications. We reviewed that the quality of oocytes and nuclear reprogramming of somatic donor cells were the main reasons of the common abnormalities in cloned animals and the low efficiency of cloning and showed the problems and outlets in therapeutic cloning, such as some basic problems in nuclear transfer affected clinical applications of therapeutic cloning. Study on isolation and culture of nuclear transfer embryonic stem (ntES) cells and specific differentiation of ntES cells into important functional cells should be emphasized and could enhance the efficiency. Adult stem cells could help to cure some great diseases, but could not replace therapeutic cloning. Ethics also impeded the development of therapeutic cloning. It is necessary to improve many techniques and reinforce the research of some basic theories, then somatic nuclear transfer and therapeutic cloning may apply to agriculture reproduction and benefit to human life better.

Basic nursing care: The most provided, the least evidence based - A discussion paper.

PubMed

Zwakhalen, Sandra M G; Hamers, Jan P H; Metzelthin, Silke F; Ettema, Roelof; Heinen, Maud; de Man-Van Ginkel, Janneke M; Vermeulen, Hester; Huisman-de Waal, Getty; Schuurmans, Marieke J

2018-06-01

To describe and discuss the "Basic Care Revisited" (BCR) research programme, a collaborative initiative that contributes to evidence-based basic nursing care and raises awareness about the importance of basic nursing care activities. While basic nursing care serves nearly all people at some point in their lifetime, it is poorly informed by evidence. There is a need to prioritise and evaluate basic nursing care activities to improve patient outcomes and improve the quality of care. Discussion paper METHOD: The discussion presented in this paper is based on nursing literature and theory and supported by the authors' clinical and research experiences. We present the developmental process and content of a research programme called "Basic Care Revisited" (BCR) as a solution to move forward and improve basic nursing care. To prioritise basic nursing care, we propose a research programme entitled "Basic Care Revisited" that aims to create awareness and expand knowledge on evidence-based basic nursing care by addressing four basic nursing care themes (bathing and dressing, communication, mobility, and nutrition) in different settings. The paper discusses a pathway to create a sustainable and productive research collaborative on basic nursing care and addresses issues to build research capacity. Revaluation of these important nursing activities will not only positively influence patient outcomes, but also have an impact on staff outcomes and organisational outcomes. © 2018 John Wiley & Sons Ltd.

Grid-independent residential power systems

NASA Astrophysics Data System (ADS)

Nelson, Robert E.

1996-02-01

A self-powered, gas-fired, warm air furnace is evaluated as a candidate for the autonomous generation of electrical power. A popular, commercial residential furnace is analyzed for electrical power requirements. Available energy conversion concepts are considered for this application, and the thermophotovoltaic (TPV) option is selected due to reliability and cost. The design and the internal components peculiar to the TPV converter will be covered. Operating results, including NOx emission, will be summarized. This work was sponsored by the Basic Research Group, Gas Research Institute, Chicago, IL.

Captain upgrade CRM training: A new focus for enhanced flight operations

NASA Technical Reports Server (NTRS)

Taggart, William R.

1993-01-01

Crew Resource Management (CRM) research has resulted in numerous payoffs of applied applications in flight training and standardization of air carrier flight operations. This paper describes one example of how basic research into human factors and crew performance was used to create a specific training intervention for upgrading new captains for a major United States air carrier. The basis for the training is examined along with some of the specific training methods used, and several unexpeced results.

IMAGESEER - IMAGEs for Education and Research

NASA Technical Reports Server (NTRS)

Le Moigne, Jacqueline; Grubb, Thomas; Milner, Barbara

2012-01-01

IMAGESEER is a new Web portal that brings easy access to NASA image data for non-NASA researchers, educators, and students. The IMAGESEER Web site and database are specifically designed to be utilized by the university community, to enable teaching image processing (IP) techniques on NASA data, as well as to provide reference benchmark data to validate new IP algorithms. Along with the data and a Web user interface front-end, basic knowledge of the application domains, benchmark information, and specific NASA IP challenges (or case studies) are provided.

SNP_tools: A compact tool package for analysis and conversion of genotype data for MS-Excel

PubMed Central

Chen, Bowang; Wilkening, Stefan; Drechsel, Marion; Hemminki, Kari

2009-01-01

Background Single nucleotide polymorphism (SNP) genotyping is a major activity in biomedical research. Scientists prefer to have a facile access to the results which may require conversions between data formats. First hand SNP data is often entered in or saved in the MS-Excel format, but this software lacks genetic and epidemiological related functions. A general tool to do basic genetic and epidemiological analysis and data conversion for MS-Excel is needed. Findings The SNP_tools package is prepared as an add-in for MS-Excel. The code is written in Visual Basic for Application, embedded in the Microsoft Office package. This add-in is an easy to use tool for users with basic computer knowledge (and requirements for basic statistical analysis). Conclusion Our implementation for Microsoft Excel 2000-2007 in Microsoft Windows 2000, XP, Vista and Windows 7 beta can handle files in different formats and converts them into other formats. It is a free software. PMID:19852806

SNP_tools: A compact tool package for analysis and conversion of genotype data for MS-Excel.

PubMed

Chen, Bowang; Wilkening, Stefan; Drechsel, Marion; Hemminki, Kari

2009-10-23

Single nucleotide polymorphism (SNP) genotyping is a major activity in biomedical research. Scientists prefer to have a facile access to the results which may require conversions between data formats. First hand SNP data is often entered in or saved in the MS-Excel format, but this software lacks genetic and epidemiological related functions. A general tool to do basic genetic and epidemiological analysis and data conversion for MS-Excel is needed. The SNP_tools package is prepared as an add-in for MS-Excel. The code is written in Visual Basic for Application, embedded in the Microsoft Office package. This add-in is an easy to use tool for users with basic computer knowledge (and requirements for basic statistical analysis). Our implementation for Microsoft Excel 2000-2007 in Microsoft Windows 2000, XP, Vista and Windows 7 beta can handle files in different formats and converts them into other formats. It is a free software.

Application of phase-trafficking methods to natural products research.

PubMed

Araya, Juan J; Montenegro, Gloria; Mitscher, Lester A; Timmermann, Barbara N

2010-09-24

A novel simultaneous phase-trafficking approach using spatially separated solid-supported reagents for rapid separation of neutral, basic, and acidic compounds from organic plant extracts with minimum labor is reported. Acidic and basic ion-exchange resins were physically separated into individual sacks ("tea bags") for trapping basic and acidic compounds, respectively, leaving behind in solution neutral components of the natural mixtures. Trapped compounds were then recovered from solid phase by appropriate suspension in acidic or basic solutions. The feasibility of the proposed separation protocol was demonstrated and optimized with an "artificial mixture" of model compounds. In addition, the utility of this methodology was illustrated with the successful separation of the alkaloid skytanthine from Skytanthus acutus Meyen and the main catechins and caffeine from Camellia sinensis L. (Kuntze). This novel approach offers multiple advantages over traditional extraction methods, as it is not labor intensive, makes use of only small quantities of solvents, produces fractions in adequate quantities for biological assays, and can be easily adapted to field conditions for bioprospecting activities.

Application of Phase-Trafficking Methods to Natural Products Research

PubMed Central

Araya, Juan J.; Montenegro, Gloria; Mitscher, Lester A.; Timmermann, Barbara N.

2010-01-01

A novel simultaneous phase-trafficking approach using spatially separated solid-supported reagents (SSR) for rapid separation of neutral, basic, and acidic compounds from organic plant extracts with minimum labor is reported. Acidic and basic ion exchange resins were physically separated into individual sacks (“teabags”) for trapping basic and acidic compounds respectively, leaving behind in solution neutral components of the natural mixtures. Trapped compounds were then recovered from solid phase by appropriate suspension in acidic or basic solutions. The feasibility of the proposed separation protocol was demonstrated and optimized with an “artificial mixture” of model compounds. In addition, the utility of this methodology was illustrated with the successful separation of the alkaloid skytanthine from Skytanthus acutus Meyen and the main catechins and caffeine from Camellia sinensis L. (Kuntze). This novel approach offers multiple advantages over traditional extraction methods, as it is not labor intensive, makes use of only small quantities of solvents, produces fractions in adequate quantities for biological assays, and can be easily adapted to field conditions for bioprospecting activities. PMID:20704309

The Solar-Terrestrial Environment

NASA Astrophysics Data System (ADS)

Hargreaves, John Keith

1995-05-01

The book begins with three introductory chapters that provide some basic physics and explain the principles of physical investigation. The principal material contained in the main part of the book covers the neutral and ionized upper atmosphere, the magnetosphere, and structures, dynamics, disturbances, and irregularities. The concluding chapter deals with technological applications. The account is introductory, at a level suitable for readers with a basic background in engineering or physics. The intent is to present basic concepts, and for that reason, the mathematical treatment is not complex. SI units are given throughout, with helpful notes on cgs units where these are likely to be encountered in the research literature. This book is suitable for advanced undergraduate and graduate students who are taking introductory courses on upper atmospheric, ionospheric, or magnetospheric physics. This is a successor to The Upper Atmosphere and Solar-Terrestrial Relations, published in 1979.

Zero Income Basic Grant Applicants. Phase II Report.

ERIC Educational Resources Information Center

Applied Management Sciences, Inc., Silver Spring, MD.

The nature and extent of corrections made to their records by zero/low income applicants to the Basic Educational Opportunity Grant (BEOG) program was investigated. Behaviors of zero/low income applicants and the total pool of applicants were also compared. It was found that zero/low income applicants and all applicants who were rejected displayed…

WE-B-BRD-01: Innovation in Radiation Therapy Planning II: Cloud Computing in RT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Moore, K; Kagadis, G; Xing, L

As defined by the National Institute of Standards and Technology, cloud computing is “a model for enabling ubiquitous, convenient, on-demand network access to a shared pool of configurable computing resources (e.g., networks, servers, storage, applications, and services) that can be rapidly provisioned and released with minimal management effort or service provider interaction.” Despite the omnipresent role of computers in radiotherapy, cloud computing has yet to achieve widespread adoption in clinical or research applications, though the transition to such “on-demand” access is underway. As this transition proceeds, new opportunities for aggregate studies and efficient use of computational resources are set againstmore » new challenges in patient privacy protection, data integrity, and management of clinical informatics systems. In this Session, current and future applications of cloud computing and distributed computational resources will be discussed in the context of medical imaging, radiotherapy research, and clinical radiation oncology applications. Learning Objectives: Understand basic concepts of cloud computing. Understand how cloud computing could be used for medical imaging applications. Understand how cloud computing could be employed for radiotherapy research.4. Understand how clinical radiotherapy software applications would function in the cloud.« less

26 CFR 1.41-5A - Basic research for taxable years beginning before January 1, 1987.

Code of Federal Regulations, 2010 CFR

2010-04-01

... was for basic research performed in the United States). (2) Research in the social sciences or humanities. Basic research does not include research in the social sciences or humanities, within the meaning...

26 CFR 1.41-5A - Basic research for taxable years beginning before January 1, 1987.

Code of Federal Regulations, 2011 CFR

2011-04-01

... was for basic research performed in the United States). (2) Research in the social sciences or humanities. Basic research does not include research in the social sciences or humanities, within the meaning...

26 CFR 1.41-5A - Basic research for taxable years beginning before January 1, 1987.

Code of Federal Regulations, 2014 CFR

2014-04-01

... was for basic research performed in the United States). (2) Research in the social sciences or humanities. Basic research does not include research in the social sciences or humanities, within the meaning...

26 CFR 1.41-5A - Basic research for taxable years beginning before January 1, 1987.

Code of Federal Regulations, 2013 CFR

2013-04-01

... was for basic research performed in the United States). (2) Research in the social sciences or humanities. Basic research does not include research in the social sciences or humanities, within the meaning...

26 CFR 1.41-5A - Basic research for taxable years beginning before January 1, 1987.

Code of Federal Regulations, 2012 CFR

2012-04-01

... was for basic research performed in the United States). (2) Research in the social sciences or humanities. Basic research does not include research in the social sciences or humanities, within the meaning...

Nanotechnology research: applications in nutritional sciences.

PubMed

Srinivas, Pothur R; Philbert, Martin; Vu, Tania Q; Huang, Qingrong; Kokini, Josef L; Saltos, Etta; Saos, Etta; Chen, Hongda; Peterson, Charles M; Friedl, Karl E; McDade-Ngutter, Crystal; Hubbard, Van; Starke-Reed, Pamela; Miller, Nancy; Betz, Joseph M; Dwyer, Johanna; Milner, John; Ross, Sharon A

2010-01-01

The tantalizing potential of nanotechnology is to fabricate and combine nanoscale approaches and building blocks to make useful tools and, ultimately, interventions for medical science, including nutritional science, at the scale of approximately 1-100 nm. In the past few years, tools and techniques that facilitate studies and interventions in the nanoscale range have become widely available and have drawn widespread attention. Recently, investigators in the food and nutrition sciences have been applying the tools of nanotechnology in their research. The Experimental Biology 2009 symposium entitled "Nanotechnology Research: Applications in Nutritional Sciences" was organized to highlight emerging applications of nanotechnology to the food and nutrition sciences, as well as to suggest ways for further integration of these emerging technologies into nutrition research. Speakers focused on topics that included the problems and possibilities of introducing nanoparticles in clinical or nutrition settings, nanotechnology applications for increasing bioavailability of bioactive food components in new food products, nanotechnology opportunities in food science, as well as emerging safety and regulatory issues in this area, and the basic research applications such as the use of quantum dots to visualize cellular processes and protein-protein interactions. The session highlighted several emerging areas of potential utility in nutrition research. Nutrition scientists are encouraged to leverage ongoing efforts in nanomedicine through collaborations. These efforts could facilitate exploration of previously inaccessible cellular compartments and intracellular pathways and thus uncover strategies for new prevention and therapeutic modalities.

Nanotechnology Research: Applications in Nutritional Sciences12

PubMed Central

Srinivas, Pothur R.; Philbert, Martin; Vu, Tania Q.; Huang, Qingrong; Kokini, Josef L.; Saos, Etta; Chen, Hongda; Peterson, Charles M.; Friedl, Karl E.; McDade-Ngutter, Crystal; Hubbard, Van; Starke-Reed, Pamela; Miller, Nancy; Betz, Joseph M.; Dwyer, Johanna; Milner, John; Ross, Sharon A.

2010-01-01

The tantalizing potential of nanotechnology is to fabricate and combine nanoscale approaches and building blocks to make useful tools and, ultimately, interventions for medical science, including nutritional science, at the scale of ∼1–100 nm. In the past few years, tools and techniques that facilitate studies and interventions in the nanoscale range have become widely available and have drawn widespread attention. Recently, investigators in the food and nutrition sciences have been applying the tools of nanotechnology in their research. The Experimental Biology 2009 symposium entitled “Nanotechnology Research: Applications in Nutritional Sciences” was organized to highlight emerging applications of nanotechnology to the food and nutrition sciences, as well as to suggest ways for further integration of these emerging technologies into nutrition research. Speakers focused on topics that included the problems and possibilities of introducing nanoparticles in clinical or nutrition settings, nanotechnology applications for increasing bioavailability of bioactive food components in new food products, nanotechnology opportunities in food science, as well as emerging safety and regulatory issues in this area, and the basic research applications such as the use of quantum dots to visualize cellular processes and protein-protein interactions. The session highlighted several emerging areas of potential utility in nutrition research. Nutrition scientists are encouraged to leverage ongoing efforts in nanomedicine through collaborations. These efforts could facilitate exploration of previously inaccessible cellular compartments and intracellular pathways and thus uncover strategies for new prevention and therapeutic modalities. PMID:19939997

Development of a Dynamically Configurable,Object-Oriented Framework for Distributed, Multi-modal Computational Aerospace Systems Simulation

NASA Technical Reports Server (NTRS)

Afjeh, Abdollah A.; Reed, John A.

2003-01-01

This research is aimed at developing a neiv and advanced simulation framework that will significantly improve the overall efficiency of aerospace systems design and development. This objective will be accomplished through an innovative integration of object-oriented and Web-based technologies ivith both new and proven simulation methodologies. The basic approach involves Ihree major areas of research: Aerospace system and component representation using a hierarchical object-oriented component model which enables the use of multimodels and enforces component interoperability. Collaborative software environment that streamlines the process of developing, sharing and integrating aerospace design and analysis models. . Development of a distributed infrastructure which enables Web-based exchange of models to simplify the collaborative design process, and to support computationally intensive aerospace design and analysis processes. Research for the first year dealt with the design of the basic architecture and supporting infrastructure, an initial implementation of that design, and a demonstration of its application to an example aircraft engine system simulation.

Introduction to the Special Section on Epigenetics.

PubMed

Lester, Barry M; Conradt, Elisabeth; Marsit, Carmen

2016-01-01

Epigenetics provides the opportunity to revolutionize our understanding of the role of genetics and the environment in explaining human behavior, although the use of epigenetics to study human behavior is just beginning. In this introduction, the authors present the basics of epigenetics in a way that is designed to make this exciting field accessible to a wide readership. The authors describe the history of human behavioral epigenetic research in the context of other disciplines and graphically illustrate the burgeoning of research in the application of epigenetic methods and principles to the study of human behavior. The role of epigenetics in normal embryonic development and the influence of biological and environmental factors altering behavior through epigenetic mechanisms and developmental programming are discussed. Some basic approaches to the study of epigenetics are reviewed. The authors conclude with a discussion of challenges and opportunities, including intervention, as the field of human behavioral epigenetics continue to grow. © 2016 The Authors. Child Development © 2016 Society for Research in Child Development, Inc.

Studies on morphology, electrical and optical characteristics of Al-doped ZnO thin films grown by atomic layer deposition

NASA Astrophysics Data System (ADS)

Chen, Li; Chen, Xinliang; Zhou, Zhongxin; Guo, Sheng; Zhao, Ying; Zhang, Xiaodan

2018-03-01

Al doped ZnO (AZO) films deposited on glass substrates through the atomic layer deposition (ALD) technique are investigated with various temperatures from 100 to 250 °C and different Zn : Al cycle ratios from 20 : 0 to 20 : 3. Surface morphology, structure, optical and electrical properties of obtained AZO films are studied in detail. The Al composition of the AZO films is varied by controlling the ratio of Zn : Al. We achieve an excellent AZO thin film with a resistivity of 2.14 × 10‑3 Ω·cm and high optical transmittance deposited at 150 °C with 20 : 2 Zn : Al cycle ratio. This kind of AZO thin films exhibit great potential for optoelectronics device application. Project supported by the State Key Development Program for Basic Research of China (Nos. 2011CBA00706, 2011CBA00707) and the Tianjin Applied Basic Research Project and Cutting-Edge Technology Research Plan (No. 13JCZDJC26900).

Electrophoresis experiments in microgravity

NASA Technical Reports Server (NTRS)

Snyder, Robert S.; Rhodes, Percy H.

1991-01-01

The use of the microgravity environment to separate and purify biological cells and proteins has been a major activity since the beginning of the NASA Microgravity Science and Applications program. Purified populations of cells are needed for research, transplantation and analysis of specific cell constituents. Protein purification is a necessary step in research areas such as genetic engineering where the new protein has to be separated from the variety of other proteins synthesized from the microorganism. Sufficient data are available from the results of past electrophoresis experiments in space to show that these experiments were designed with incomplete knowledge of the fluid dynamics of the process including electrohydrodynamics. However, electrophoresis is still an important separation tool in the laboratory and thermal convection does limit its performance. Thus, there is a justification for electrophoresis but the emphasis of future space experiments must be directed toward basic research with model experiments to understand the microgravity environment and fluid analysis to test the basic principles of the process.

Infrared spectroscopy and microscopy in cancer research and diagnosis

PubMed Central

Bellisola, Giuseppe; Sorio, Claudio

2012-01-01

Since the middle of 20th century infrared (IR) spectroscopy coupled to microscopy (IR microspectroscopy) has been recognized as a non destructive, label free, highly sensitive and specific analytical method with many potential useful applications in different fields of biomedical research and in particular cancer research and diagnosis. Although many technological improvements have been made to facilitate biomedical applications of this powerful analytical technique, it has not yet properly come into the scientific background of many potential end users. Therefore, to achieve those fundamental objectives an interdisciplinary approach is needed with basic scientists, spectroscopists, biologists and clinicians who must effectively communicate and understand each other's requirements and challenges. In this review we aim at illustrating some principles of Fourier transform (FT) Infrared (IR) vibrational spectroscopy and microscopy (microFT-IR) as a useful method to interrogate molecules in specimen by mid-IR radiation. Penetrating into basics of molecular vibrations might help us to understand whether, when and how complementary information obtained by microFT-IR could become useful in our research and/or diagnostic activities. MicroFT-IR techniques allowing to acquire information about the molecular composition and structure of a sample within a micrometric scale in a matter of seconds will be illustrated as well as some limitations will be discussed. How biochemical, structural, and dynamical information about the systems can be obtained by bench top microFT-IR instrumentation will be also presented together with some methods to treat and interpret IR spectral data and applicative examples. The mid-IR absorbance spectrum is one of the most information-rich and concise way to represent the whole “… omics” of a cell and, as such, fits all the characteristics for the development of a clinically useful biomarker. PMID:22206042

Basic Skills, Basic Writing, Basic Research.

ERIC Educational Resources Information Center

Trimmer, Joseph F.

1987-01-01

Overviews basic writing instruction and research by briefly discussing the history of remediation, results of a survey of basic writing programs in U.S. colleges and universities, and interviews with developmental textbook editors at major publishing houses. Finds that basic writing instruction continues to focus on sentence grammar. (MM)

Application of virtual reality methods to obesity prevention and management research.

PubMed

Persky, Susan

2011-03-01

There is a great need for empirical evidence to inform clinical prevention and management of overweight and obesity. Application of virtual reality (VR) methods to this research agenda could present considerable advantages. Use of VR methods in basic and applied obesity prevention and treatment research is currently extremely limited. However, VR has been employed for social and behavioral research in many other domains where it has demonstrated validity and utility. Advantages of VR technologies as research tools include the ability to situate hypothetical research scenarios in realistic settings, tight experimental control inherent in virtual environments, the ability to manipulate and control any and all scenario elements, and enhanced behavioral measurement opportunities. The means by which each of these features could enhance obesity prevention and management research is discussed and illustrated in the context of an example research study. Challenges associated with the application of VR methods, such as technological limitations and cost, are also considered. By employing experimental VR methods to interrogate clinical encounters and other health-related situations, researchers may be able to elucidate causal relationships, strengthen theoretical models, and identify potential targets for intervention. In so doing, researchers stand to make important contributions to evidence-based practice innovation in weight management and obesity prevention. © 2011 Diabetes Technology Society.

Application of Virtual Reality Methods to Obesity Prevention and Management Research

PubMed Central

Persky, Susan

2011-01-01

There is a great need for empirical evidence to inform clinical prevention and management of overweight and obesity. Application of virtual reality (VR) methods to this research agenda could present considerable advantages. Use of VR methods in basic and applied obesity prevention and treatment research is currently extremely limited. However, VR has been employed for social and behavioral research in many other domains where it has demonstrated validity and utility. Advantages of VR technologies as research tools include the ability to situate hypothetical research scenarios in realistic settings, tight experimental control inherent in virtual environments, the ability to manipulate and control any and all scenario elements, and enhanced behavioral measurement opportunities. The means by which each of these features could enhance obesity prevention and management research is discussed and illustrated in the context of an example research study. Challenges associated with the application of VR methods, such as technological limitations and cost, are also considered. By employing experimental VR methods to interrogate clinical encounters and other health-related situations, researchers may be able to elucidate causal relationships, strengthen theoretical models, and identify potential targets for intervention. In so doing, researchers stand to make important contributions to evidence-based practice innovation in weight management and obesity prevention. PMID:21527102

Translational research in genomics of Alzheimer's disease: a review of current practice and future perspectives.

PubMed

Mihaescu, Raluca; Detmar, Symone B; Cornel, Martina C; van der Flier, Wiesje M; Heutink, Peter; Hol, Elly M; Rikkert, Marcel G M Olde; van Duijn, Cornelia M; Janssens, A Cecile J W

2010-01-01

Alzheimer's disease (AD) is the most prevalent form of dementia and the number of cases is expected to increase exponentially worldwide. Three highly penetrant genes (AbetaPP, PSEN1, and PSEN2) explain only a small number of AD cases with a Mendelian transmission pattern. Many genes have been analyzed for association with non-Mendelian AD, but the only consistently replicated finding is APOE. At present, possibilities for prevention, early detection, and treatment of the disease are limited. Predictive and diagnostic genetic testing is available only in Mendelian forms of AD. Currently, APOE genotyping is not considered clinically useful for screening, presymptomatic testing, or clinical diagnosis of non-Mendelian AD. However, clinical management of the disease is expected to benefit from the rapid pace of discoveries in the genomics of AD. Following a recently developed framework for the continuum of translation research that is needed to move genetic discoveries to health applications, this paper reviews recent genetic discoveries as well as translational research on genomic applications in the prevention, early detection, and treatment of AD. The four phases of translation research include: 1) translation of basic genomics research into a potential health care application; 2) evaluation of the application for the development of evidence-based guidelines; 3) evaluation of the implementation and use of the application in health care practice; and 4) evaluation of the achieved population health impact. Most research on genome-based applications in AD is still in the first phase of the translational research framework, which means that further research is still needed before their implementation can be considered.

"The Dilemma That Still Counts": Basic Writing at a Political Crossroads.

ERIC Educational Resources Information Center

Harrington, Susanmarie; Adler-Kassner, Linda

1998-01-01

Reviews definitions of basic writers and basic writing over the last 20 years. Argues that basic writers are not defined only in terms of institutional convenience. Offers future directions for basic writing research, suggesting that to learn more about basic writers, researchers must return to studies of error informed by basic writing's rich…

T/BEST: Technology Benefit Estimator for Composites and Applications to Engine Structures

NASA Technical Reports Server (NTRS)

Chamis, Christos

1997-01-01

Progress in the field of aerospace propulsion has heightened the need to combine advanced technologies. These benefits will provide guidelines for identifying and prioritizing high-payoff research areas, will help manage research with limited resources, and will show the link between advanced and basic concepts. An effort was undertaken at the NASA Lewis Research Center to develop a formal computational method, T/BEST (Technology Benefit Estimator), to assess advanced aerospace technologies, such as fibrous composites, and credibly communicate the benefits of research. Fibrous composites are ideal for structural applications such as high-performance aircraft engine blades where high strength-to-weight and stiffness-to-weight ratios are required. These factors - along with the flexibility to select the composite system and layup, and to favorably orient fiber directions - reduce the displacements and stresses caused by large rotational speeds in aircraft engines.

Space Rocks Tell Their Secrets: Space Science Applications of Physics and Chemistry for High School and College Classes: Update

NASA Technical Reports Server (NTRS)

Lindstrom, M. M.; Tobola, K. W.; Stocco, K.; Henry, M.; Allen, J. S.; McReynolds, Julie; Porter, T. Todd; Veile, Jeri

2004-01-01

As the scientific community studies Mars remotely for signs of life and uses Martian meteorites as its only available samples, teachers, students, and the general public continue to ask, How do we know these meteorites are from Mars? This question sets the stage for a six-lesson instructional package Space Rocks Tell Their Secrets. Expanding on the short answer It s the chemistry of the rock , students are introduced to the research that reveals the true identities of the rocks. Since few high school or beginning college students have the opportunity to participate in this level of research, a slide presentation introduces them to the labs, samples, and people involved with the research. As they work through the lessons and interpret authentic data, students realize that the research is an application of two basic science concepts taught in the classroom, the electromagnetic spectrum and isotopes.

Clinical Use of Probiotics in Pediatric Allergy (cuppa): A World Allergy Organization Position Paper

PubMed Central

2012-01-01

Background Probiotic administration has been proposed for the prevention and treatment of specific allergic manifestations such as eczema, rhinitis, gastrointestinal allergy, food allergy, and asthma. However, published statements and scientific opinions disagree about the clinical usefulness. Objective A World Allergy Organization Special Committee on Food Allergy and Nutrition review of the evidence regarding the use of probiotics for the prevention and treatment of allergy. Methods A qualitative and narrative review of the literature on probiotic treatment of allergic disease was carried out to address the diversity and variable quality of relevant studies. This variability precluded systematization, and an expert panel group discussion method was used to evaluate the literature. In the absence of systematic reviews of treatment, meta-analyses of prevention studies were used to provide data in support of probiotic applications. Results Despite the plethora of literature, probiotic research is still in its infancy. There is a need for basic microbiology research on the resident human microbiota. Mechanistic studies from biology, immunology, and genetics are needed before we can claim to harness the potential of immune modulatory effects of microbiota. Meanwhile, clinicians must take a step back and try to link disease state with alterations of the microbiota through well-controlled long-term studies to identify clinical indications. Conclusions Probiotics do not have an established role in the prevention or treatment of allergy. No single probiotic supplement or class of supplements has been demonstrated to efficiently influence the course of any allergic manifestation or long-term disease or to be sufficient to do so. Further epidemiologic, immunologic, microbiologic, genetic, and clinical studies are necessary to determine whether probiotic supplements will be useful in preventing allergy. Until then, supplementation with probiotics remains empirical in allergy medicine. In the future, basic research should focus on homoeostatic studies, and clinical research should focus on preventive medicine applications, not only in allergy. Collaborations between allergo-immunologists and microbiologists in basic research and a multidisciplinary approach in clinical research are likely to be the most fruitful. PMID:23282383

Magnetic particle imaging: from proof of principle to preclinical applications

NASA Astrophysics Data System (ADS)

Knopp, T.; Gdaniec, N.; Möddel, M.

2017-07-01

Tomographic imaging has become a mandatory tool for the diagnosis of a majority of diseases in clinical routine. Since each method has its pros and cons, a variety of them is regularly used in clinics to satisfy all application needs. Magnetic particle imaging (MPI) is a relatively new tomographic imaging technique that images magnetic nanoparticles with a high spatiotemporal resolution in a quantitative way, and in turn is highly suited for vascular and targeted imaging. MPI was introduced in 2005 and now enters the preclinical research phase, where medical researchers get access to this new technology and exploit its potential under physiological conditions. Within this paper, we review the development of MPI since its introduction in 2005. Besides an in-depth description of the basic principles, we provide detailed discussions on imaging sequences, reconstruction algorithms, scanner instrumentation and potential medical applications.

An experimental study of potential residential and commercial applications of small-scale hybrid power systems

NASA Astrophysics Data System (ADS)

Acosta, Michael Anthony

The research presented in this thesis provides an understanding of small-scale hybrid power systems. Experiments were conducted to identify potential applications of renewable energy in residential and commercial applications in the Rio Grande Valley of Texas. Solar and wind energy converted into electric energy was stored in batteries and inverted to power common household and commercial appliances. Several small to medium size hybrid power systems were setup and utilized to conduct numerous tests to study renewable energy prospects and feasibility for various applications. The experimental results obtained indicate that carefully constructed solar power systems can provide people living in isolated communities with sufficient energy to consistently meet their basic power needs.

Microwave Tissue Ablation: Biophysics, Technology and Applications

PubMed Central

2010-01-01

Microwave ablation is an emerging treatment option for many cancers, cardiac arrhythmias and other medical conditions. During treatment, microwaves are applied directly to tissues to produce rapid temperature elevations sufficient to produce immediate coagulative necrosis. The engineering design criteria for each application differ, with individual consideration for factors such as desired ablation zone size, treatment duration, and procedural invasiveness. Recent technological developments in applicator cooling, power control and system optimization for specific applications promise to increase the utilization of microwave ablation in the future. This article will review the basic biophysics of microwave tissue heating, provide an overview of the design and operation of current equipment, and outline areas for future research for microwave ablation. PMID:21175404

Effect of Basicity on Basic Oxygen Furnace (BOF) Slag Solidification Microstructure and Mineralogy

NASA Astrophysics Data System (ADS)

Liu, Chunwei; Guo, Muxing; Pandelaers, Lieven; Blanpain, Bart; Huang, Shuigen

Slag valorization in added value construction applications can contribute substantially to the sustainability of steel industry. The present work aims to investigate the crystallization behavior of a typical industrial Basic Oxygen Furnace (BOF) slag (CaO-FeOx-SiO2-based slag) by varying the basicity through hot stage engineering. A sample of industry Basic Oxygen Slag (BOF) was mixed with different quantities of silica (SiO2) to modify basicity. The effect of basicity on solidification microstructure and mineralogy was studied. The results suggest that the mineralogy of the solidified slag can be manipulated to enhance its suitability as raw material for construction applications.

PREFACE: Synthesis and integration of nanowires

NASA Astrophysics Data System (ADS)

Samuelson, L.

2006-06-01

The field of semiconductor nanowires has attracted much attention in recent years, from the areas of basic materials science, advanced characterization and technology, as well as from the perspective of the applications of nanowires. Research on large-sized whiskers and wires had already begun in the 1960s with the pioneering work of Wagner, as well as by other researchers. It was, however, in the early 1990s that Kenji Hiruma at Hitachi Central Research Laboratories in Japan first succeeded in developing methods for the growth of nanowires with dimensions on the scale of 10-100 nm, thereby initiating the field of growth and applications of nanowires, with a strong emphasis on epitaxial nucleation of nanowires on a single-crystalline substrate. Starting from the mid-1990s, the field developed very rapidly with the number of papers on the subject growing from ten per year to several thousand papers on the subject published annually today, although with a rather generous definition of the concept of nanowires. With this rapid development we have seen many new and different approaches to the growth of nanowires, technological advances leading to a more well-controlled formation of nanowires, new innovative methods for the characterization of structures, as well as a wealth of approaches towards the use of nanowires in electronics, photonics and sensor applications. This issue contains contributions from many different laboratories, each adding significant detail to the development of the field of research. The contributions cover issues such as basic growth, advanced characterization and technology, and application of nanowires. I would like to acknowledge the shared responsibilities for this special issue of Nanotechnology on the synthesis and integration of nanowires with my co-Editors, S Tong Lee and M Sunkara, as well as the highly professional support from Dr Nina Couzin, Dr Ian Forbes and the Nanotechnology team from the Institute of Physics Publishing.

Manufacturing methods and applications of membranes in microfluidics.

PubMed

Chen, Xueye; Shen, Jienan; Hu, Zengliang; Huo, Xuyao

2016-12-01

Applications of membranes in microfluidics solved many thorny problems for analytical chemistry and bioscience, so that the use of membranes in microfluidics has been a topic of growing interest. Many different examples have been reported, demonstrating the versatile use of membranes. This work reviews a lot of applications of membranes in microfluidics. Membranes in microfluidics for applications including chemical reagents detection, gas detection, drug screening, cell, protein, microreactor, electrokinetical fluid, pump and valve and fluid transport control and so on, have been analyzed and discussed. In addition, the definition and basic concepts of membranes are summed up. And the methods of manufacturing membranes in microfluidics are discussed. This paper will provide a helpful reference to researchers who want to study applications of membranes in microfluidics.

Three-Dimensional Printing: Basic Principles and Applications in Medicine and Radiology.

PubMed

Kim, Guk Bae; Lee, Sangwook; Kim, Haekang; Yang, Dong Hyun; Kim, Young-Hak; Kyung, Yoon Soo; Kim, Choung-Soo; Choi, Se Hoon; Kim, Bum Joon; Ha, Hojin; Kwon, Sun U; Kim, Namkug

2016-01-01

The advent of three-dimensional printing (3DP) technology has enabled the creation of a tangible and complex 3D object that goes beyond a simple 3D-shaded visualization on a flat monitor. Since the early 2000s, 3DP machines have been used only in hard tissue applications. Recently developed multi-materials for 3DP have been used extensively for a variety of medical applications, such as personalized surgical planning and guidance, customized implants, biomedical research, and preclinical education. In this review article, we discuss the 3D reconstruction process, touching on medical imaging, and various 3DP systems applicable to medicine. In addition, the 3DP medical applications using multi-materials are introduced, as well as our recent results.

Opportunities for research in aerothermodynamics

NASA Technical Reports Server (NTRS)

Graham, R. W.

1983-01-01

"Aerothermodynamics' involves the disciplines of chemistry, thermodynamics, fluid mechanics and heat transfer which have collaborative importance in propulsion systems. There are growing opportunities for the further application of these disciplines to improve the methodology for the design of advanced gas turbines; particularly, the combustor and turbine. Design procedures follow empirical or cut and try guidelines. The tremendous advances in computational analysis and in instrumentation techniques hold promise for research answers to complex physical processes that are currently not well understood. The transfer of basic research understanding to engineering design should result in shorter, less expensive development commitments for engines. The status and anticipated opportunities in research topics relevant to combustors and turbines is reviewed.

Mediator and moderator effects in developmental and behavioral pediatric research.

PubMed

Rose, Brigid M; Holmbeck, Grayson N; Coakley, Rachael Millstein; Franks, Elizabeth A

2004-02-01

The terms mediation and moderation are defined and clarified with particular emphasis on the role of mediational and moderational analyses in developmental and behavioral pediatric research. The article highlights the applicability of mediational and moderational analyses to longitudinal, intervention, and risk and protective factor research, and it provides basic information about how these analyses might be conducted. Also included is a discussion of various ways that both mediator and moderator variables can be incorporated into a single model. The article concludes with extended examples of both types of analyses using a longitudinal pediatric study for illustration. The article provides recommendations for applying mediational and moderational research in clinical practice.

Modeling and Experiments with Carbon Nanotubes for Applications in High Performance Circuits

DTIC Science & Technology

2017-04-06

purchased and installed for experimental characterization of atomic layer deposited graphene on different substrates for radiation-hardened studies...72 3.6 Experimental Research in Graphene for Radiation Hardened Devices……………..73 4 Recommendations...physics for analysis and design of integrated circuits. The developed model is verified from published experimental data. Basic logic gates in

AFRL Nanoscience Technologies: Applications, Transitions and Innovations

DTIC Science & Technology

2010-01-01

other electromagnetic energy; they can interact with magnetic domains for improved superconductivity; they strengthen metals by resisting the motion of...thick platinum silicide (PtSi) layer on a silicon substrate. The basic research to establish the process of internal photoemission responsible for...pulses, saving 150 lbs per aircraft over the current metal shielding. Electrically conductive coatings using nickel nanostrands are now fielded in other

The Owner's Manual for the Brain: Everyday Applications from Mind-Brain Research. Second Edition.

ERIC Educational Resources Information Center

Howard, Pierce J.

This book discusses what is known about the brain and memory storage and how people can improve their recall of information. There are 10 parts with 37 chapters. Part 1, "Forming a Foundation: The Context for Using Your Owner's Manual," includes topics like brain basics and brain imaging. Part 2, "Wellness: Getting the Most Out of…

Structural Mass Spectrometry of Proteins Using Hydroxyl Radical Based Protein Footprinting

PubMed Central

Wang, Liwen; Chance, Mark R.

2011-01-01

Structural MS is a rapidly growing field with many applications in basic research and pharmaceutical drug development. In this feature article the overall technology is described and several examples of how hydroxyl radical based footprinting MS can be used to map interfaces, evaluate protein structure, and identify ligand dependent conformational changes in proteins are described. PMID:21770468

Application of the biosafety RAM and eProtocol software programs to streamline institutional biosafety committee processes at the USDA-National Animal Disease Center

USDA-ARS?s Scientific Manuscript database

The National Animal Disease Center (NADC) conducts basic and applied research on endemic animal diseases of high priority that adversely affect U.S. livestock production or trade. Experiments conducted at this Center vary in range and scope, with a subset involving synthetic or recombinant nucleic a...

Simple Estimators for the Simple Latent Class Mastery Testing Model. Twente Educational Memorandum No. 19.

ERIC Educational Resources Information Center

van der Linden, Wim J.

Latent class models for mastery testing differ from continuum models in that they do not postulate a latent mastery continuum but conceive mastery and non-mastery as two latent classes, each characterized by different probabilities of success. Several researchers use a simple latent class model that is basically a simultaneous application of the…

Watersheds in Baltimore, Maryland: understanding and application of integrated ecological and social processes

Treesearch

Steward T.A. Pickett; Kenneth T. Belt; Michael F. Galvin; Peter M. Groffman; J. Morgan Grove; Donald C. Outen; Richard V. Pouyat; William P. Stack; Mary L. Cadenasso

2007-01-01

The Water and Watersheds program has made significant and lasting contributions to the basic understanding of the complex ecological system of Baltimore, MD. Funded at roughly the same time as the urban Long- Term Ecological Research (LTER) project in Baltimore, the Water and Watersheds grant and the LTER grant together established the Baltimore Ecosystem Study (BES)...

A comparison of Freon- and water-based insecticidal aerosols for aircraft disinsection*

PubMed Central

Sullivan, W. N.; Cawley, B. M.; Schechter, M. S.; Hayes, D. K.; Staker, Kathleen; Pal, R.

1978-01-01

In Miami, USA, passenger compartments of wide-bodied jet aircraft were disinsected at ”blocks away” or while parked. The application of 2% Freon- and water-based formulations of (+)-phenothrin at about 35 g/100 m3 was highly effective against mosquitos and flies in all instances. More basic research is needed on water-based aerosols. PMID:307441

Bias in Research Grant Evaluation Has Dire Consequences for Small Universities.

PubMed

Murray, Dennis L; Morris, Douglas; Lavoie, Claude; Leavitt, Peter R; MacIsaac, Hugh; Masson, Michael E J; Villard, Marc-Andre

2016-01-01

Federal funding for basic scientific research is the cornerstone of societal progress, economy, health and well-being. There is a direct relationship between financial investment in science and a nation's scientific discoveries, making it a priority for governments to distribute public funding appropriately in support of the best science. However, research grant proposal success rate and funding level can be skewed toward certain groups of applicants, and such skew may be driven by systemic bias arising during grant proposal evaluation and scoring. Policies to best redress this problem are not well established. Here, we show that funding success and grant amounts for applications to Canada's Natural Sciences and Engineering Research Council (NSERC) Discovery Grant program (2011-2014) are consistently lower for applicants from small institutions. This pattern persists across applicant experience levels, is consistent among three criteria used to score grant proposals, and therefore is interpreted as representing systemic bias targeting applicants from small institutions. When current funding success rates are projected forward, forecasts reveal that future science funding at small schools in Canada will decline precipitously in the next decade, if skews are left uncorrected. We show that a recently-adopted pilot program to bolster success by lowering standards for select applicants from small institutions will not erase funding skew, nor will several other post-evaluation corrective measures. Rather, to support objective and robust review of grant applications, it is necessary for research councils to address evaluation skew directly, by adopting procedures such as blind review of research proposals and bibliometric assessment of performance. Such measures will be important in restoring confidence in the objectivity and fairness of science funding decisions. Likewise, small institutions can improve their research success by more strongly supporting productive researchers and developing competitive graduate programming opportunities.

Bias in Research Grant Evaluation Has Dire Consequences for Small Universities

PubMed Central

Murray, Dennis L.; Morris, Douglas; Lavoie, Claude; Leavitt, Peter R.; MacIsaac, Hugh; Masson, Michael E. J.; Villard, Marc-Andre

2016-01-01

Federal funding for basic scientific research is the cornerstone of societal progress, economy, health and well-being. There is a direct relationship between financial investment in science and a nation’s scientific discoveries, making it a priority for governments to distribute public funding appropriately in support of the best science. However, research grant proposal success rate and funding level can be skewed toward certain groups of applicants, and such skew may be driven by systemic bias arising during grant proposal evaluation and scoring. Policies to best redress this problem are not well established. Here, we show that funding success and grant amounts for applications to Canada’s Natural Sciences and Engineering Research Council (NSERC) Discovery Grant program (2011–2014) are consistently lower for applicants from small institutions. This pattern persists across applicant experience levels, is consistent among three criteria used to score grant proposals, and therefore is interpreted as representing systemic bias targeting applicants from small institutions. When current funding success rates are projected forward, forecasts reveal that future science funding at small schools in Canada will decline precipitously in the next decade, if skews are left uncorrected. We show that a recently-adopted pilot program to bolster success by lowering standards for select applicants from small institutions will not erase funding skew, nor will several other post-evaluation corrective measures. Rather, to support objective and robust review of grant applications, it is necessary for research councils to address evaluation skew directly, by adopting procedures such as blind review of research proposals and bibliometric assessment of performance. Such measures will be important in restoring confidence in the objectivity and fairness of science funding decisions. Likewise, small institutions can improve their research success by more strongly supporting productive researchers and developing competitive graduate programming opportunities. PMID:27258385

Production of Medical Isotopes with Electron Linacs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rotsch, D A; Alford, K.; Bailey, J. L.

Radioisotopes play important roles in numerous areas ranging from medical treatments to national security and basic research. Radionuclide production technology for medical applications has been pursued since the early 1900s both commercially and in nuclear science centers. Many medical isotopes are now in routine production and are used in day-to-day medical procedures. Despite these advancements, research is accelerating around the world to improve the existing production methodologies as well as to develop novel radionuclides for new medical appli-cations. Electron linear accelerators (linacs) represent a unique method for the production of radioisotopes. Even though the basic technology has been around formore » decades, only recently have electron linacs capable of producing photons with sufficient energy and flux for radioisotope production become available. Housed in Argonne Nation-al Laboratory’s Low Energy Accelerator Facility (LEAF) is a newly upgraded 55 MeV/25-kW electron linear ac-celerator, capable of producing a wide range of radioiso-topes. This talk will focus on the work being performed for the production of the medical isotopes 99Mo (99Mo/99mTc generator), 67Cu, and 47Sc.« less