NASA Office of Aeronautics and Space Technology Summer Workshop. Volume 10: Basic research panel

NASA Technical Reports Server (NTRS)

1975-01-01

Possible research experiments using the space transportation system are identified based on user requirements. Opportunity driven research areas include quantum electronics, cryogenics system technology, superconducting devices and detectors, and photo-induced reactions. Mission driven research requirements were examined and ranked based on inputs from the user group.

Quality in the Basic Grant Delivery System: Volume 3, Methodology.

ERIC Educational Resources Information Center

Advanced Technology, Inc., McLean, VA.

The research methodology of a study to assess 1980-1981 award accuracy of the Basic Educational Opportunity Grants (BEOG), or Pell grants, is described. The study is the first stage of a three-stage quality control project. During the spring of 1981 a nationally representative sample of 305 public, private, and proprietary institutions was…

75 FR 27782 - Federal Acquisition Regulation; Submission for OMB Review; Rights in Data and Copyrights

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-18

... experimental, developmental, research, or demonstration work (other than basic or applied research to be... fully evaluate the research in order to ascertain future activities and to insure that the research was completed and fully reported, as well as to give the public an opportunity to assess the research results...

Opportunities for research in space life sciences aboard commercial suborbital flights.

PubMed

Wagner, Erika B; Charles, John B; Cuttino, Charles Marsh

2009-11-01

The emergence of commercial suborbital spaceflight offers a wide range of new research and development opportunities for those in the space life sciences. Large numbers of diverse flyers, frequent re-flights, and flexible operations provide a fertile ground for both basic and applied science, as well as technology demonstrations. This commentary explores some of the unique features available to the space life science community and encourages engagement with commercial developers and operators during the design phase to help optimize platform designs and operations for future research.

Summer Undergraduate Research Program: Environmental studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

McMillan, J.

1994-12-31

The purpose of the summer undergraduate internship program for research in environmental studies is to provide an opportunity for well-qualified students to undertake an original research project as an apprentice to an active research scientist in basic environmental research. The students are offered research topics at the Medical University in the scientific areas of pharmacology and toxicology, epidemiology and risk assessment, environmental microbiology, and marine sciences. Students are also afforded the opportunity to work with faculty at the University of Charleston, SC, on projects with an environmental theme. Ten well-qualified students from colleges and universities throughout the eastern United Statesmore » were accepted into the program.« less

Town Meeting on Plasma Physics at the National Science Foundation

NASA Astrophysics Data System (ADS)

2015-11-01

We invite you to the Town Meeting on the role of the National Science Foundation (NSF) in supporting basic and applied research in Plasma Physics in the U.S. The overarching goal of NSF is to promote the progress of science and to enable training of the next generation of scientists and engineers at US colleges and universities. In this context, the role of the NSF Physics Division in leading the nearly 20 year old NSF/DOE Partnership in Basic Plasma Science and Engineering serves as an example of the long history of NSF support for basic plasma physics research. Yet, the NSF interest in maintaining a healthy university research base in plasma sciences extends across the Foundation. A total of five NSF Divisions are participating in the most recent Partnership solicitation, and a host of other multi-disciplinary and core programs provide opportunities for scientists to perform research on applications of plasma physics to Space & Solar Physics, Astrophysics, Accelerator Science, Material Science, Plasma Medicine, and many sub-disciplines within Engineering. This Town Meeting will provide a chance to discuss the full range of relevant NSF funding opportunities, and to begin a conversation on the present and future role of NSF in stewarding basic plasma science and engineering research at US colleges and universities. We would like to particularly encourage early career scientists and graduate students to participate in this Town Meeting, though everyone is invited to join what we hope to be a lively discussion.

Reinventing Biostatistics Education for Basic Scientists

PubMed Central

Weissgerber, Tracey L.; Garovic, Vesna D.; Milin-Lazovic, Jelena S.; Winham, Stacey J.; Obradovic, Zoran; Trzeciakowski, Jerome P.; Milic, Natasa M.

2016-01-01

Numerous studies demonstrating that statistical errors are common in basic science publications have led to calls to improve statistical training for basic scientists. In this article, we sought to evaluate statistical requirements for PhD training and to identify opportunities for improving biostatistics education in the basic sciences. We provide recommendations for improving statistics training for basic biomedical scientists, including: 1. Encouraging departments to require statistics training, 2. Tailoring coursework to the students’ fields of research, and 3. Developing tools and strategies to promote education and dissemination of statistical knowledge. We also provide a list of statistical considerations that should be addressed in statistics education for basic scientists. PMID:27058055

Japanese medical students' interest in basic sciences: a questionnaire survey of a medical school in Japan.

PubMed

Yamazaki, Yuka; Uka, Takanori; Shimizu, Haruhiko; Miyahira, Akira; Sakai, Tatsuo; Marui, Eiji

2013-02-01

The number of physicians engaged in basic sciences and teaching is sharply decreasing in Japan. To alleviate this shortage, central government has increased the quota of medical students entering the field. This study investigated medical students' interest in basic sciences in efforts to recruit talent. A questionnaire distributed to 501 medical students in years 2 to 6 of Juntendo University School of Medicine inquired about sex, grade, interest in basic sciences, interest in research, career path as a basic science physician, faculties' efforts to encourage students to conduct research, increases in the number of lectures, and practical training sessions on research. Associations between interest in basic sciences and other variables were examined using χ(2) tests. From among the 269 medical students (171 female) who returned the questionnaire (response rate 53.7%), 24.5% of respondents were interested in basic sciences and half of them considered basic sciences as their future career. Obstacles to this career were their original aim to become a clinician and concerns about salary. Medical students who were likely to be interested in basic sciences were fifth- and sixth-year students, were interested in research, considered basic sciences as their future career, considered faculties were making efforts to encourage medical students to conduct research, and wanted more research-related lectures. Improving physicians' salaries in basic sciences is important for securing talent. Moreover, offering continuous opportunities for medical students to experience research and encouraging advanced-year students during and after bedside learning to engage in basic sciences are important for recruiting talent.

Cancer Research Training Award Fellowship Opportunity Announcement | DCCPS/NCI/NIH

Cancer.gov

Cancer control science is the conduct of basic and applied research in the behavioral, social, and population sciences to create or enhance interventions that, independently or in combination with biomedical approaches, reduce cancer risk, incidence, morbidity and mortality, and improve quality of life.

Using the Balanced Scorecard to Enhance Undergraduate Education in a First Year Business Course: A Pilot Study

ERIC Educational Resources Information Center

Hunt, Irma; Taylor, Ronald K.; Winter, Anthony; Mackie, J. Jay; Fisher, Daniel

2016-01-01

Several research studies found that managers lacked a basic understanding of a balanced scorecard (BSC) approach to evaluate an organization. Because of this, the authors saw an opportunity to reorganize a course in order to provide students with an opportunity to address this issue. Therefore, a recent pilot study was conducted to ascertain…

Basic Education in El Salvador: Consolidating the Foundations for Quality and Equal Opportunities

ERIC Educational Resources Information Center

Rincon, Hernan, Ed.; Sala, Mariella, Ed.; Sala, Fiorella, Ed.; Tarnapol Whitacre, Paula, Ed.; Lee, Thomas, Ed.

2005-01-01

This study of basic education in El Salvador was carried out between September and December of 2003 by a team of researchers. This publication has two parts: (1) The introduction which addresses the main findings of the study and proposes education policy priorities for the next reform effort; and (2) A summary of the original study of basic…

Research briefing on contemporary problems in plasma science

NASA Technical Reports Server (NTRS)

1991-01-01

An overview is presented of the broad perspective of all plasma science. Detailed discussions are given of scientific opportunities in various subdisciplines of plasma science. The first subdiscipline to be discussed is the area where the contemporary applications of plasma science are the most widespread, low temperature plasma science. Opportunities for new research and technology development that have emerged as byproducts of research in magnetic and inertial fusion are then highlighted. Then follows a discussion of new opportunities in ultrafast plasma science opened up by recent developments in laser and particle beam technology. Next, research that uses smaller scale facilities is discussed, first discussing non-neutral plasmas, and then the area of basic plasma experiments. Discussions of analytic theory and computational plasma physics and of space and astrophysical plasma physics are then presented.

Scientific Cooperation Between the U.S. and the Republic of South Africa Funds 7 Cancer-Specific Pro

Cancer.gov

The NIH has recently awarded its first round of grants in a parallel U.S.-South Africa funding opportunity. Initiatives funded through this program will advance biomedical research for tuberculosis and HIV/AIDS in not only the US and South Africa, but will contribute to the global wealth of knowledge of these diseases. The scope of this initiative includes HIV/AIDS co-morbidities, and resulting malignancies. This opportunity was further targeted at expanding basic, translational, behavioral and applied research that will stimulate scientific discovery, and engage U.S. and South African researcher collaboration.

Academic research opportunities at the National Geospatial-Intelligence Agency(NGA)

NASA Astrophysics Data System (ADS)

Loomer, Scott A.

2006-05-01

The vision of the National Geospatial-Intelligence Agency (NGA) is to "Know the Earth...Show the Way." To achieve this vision, the NGA provides geospatial intelligence in all its forms and from whatever source-imagery, imagery intelligence, and geospatial data and information-to ensure the knowledge foundation for planning, decision, and action. Academia plays a key role in the NGA research and development program through the NGA Academic Research Program. This multi-disciplinary program of basic research in geospatial intelligence topics provides grants and fellowships to the leading investigators, research universities, and colleges of the nation. This research provides the fundamental science support to NGA's applied and advanced research programs. The major components of the NGA Academic Research Program are: *NGA University Research Initiatives (NURI): Three-year basic research grants awarded competitively to the best investigators across the US academic community. Topics are selected to provide the scientific basis for advanced and applied research in NGA core disciplines. *Historically Black College and University - Minority Institution Research Initiatives (HBCU-MI): Two-year basic research grants awarded competitively to the best investigators at Historically Black Colleges and Universities, and Minority Institutions across the US academic community. *Intelligence Community Post-Doctoral Research Fellowships: Fellowships providing access to advanced research in science and technology applicable to the intelligence community's mission. The program provides a pool of researchers to support future intelligence community needs and develops long-term relationships with researchers as they move into career positions. This paper provides information about the NGA Academic Research Program, the projects it supports and how researchers and institutions can apply for grants under the program. In addition, other opportunities for academia to engage with NGA through training programs and recruitment are discussed.

The Area IV Soil Conservation Districts Cooperative Research Farm: Thirty years of collaborative research to improve cropping system sustainability in the Northern Plains

USDA-ARS?s Scientific Manuscript database

Findings and interpretations generated from long-term cropping system studies serve to inform the status and trajectory of ecosystem services, while concurrently providing opportunities for further inquiry related to basic/fundamental research. Recent calls for increased investment in long-term cro...

Optimising Translational Research Opportunities: A Systematic Review and Narrative Synthesis of Basic and Clinician Scientists' Perspectives of Factors Which Enable or Hinder Translational Research

PubMed Central

Sadler, Euan; Fisher, Helen R.; Maher, John; Wolfe, Charles D. A.; McKevitt, Christopher

2016-01-01

Introduction Translational research is central to international health policy, research and funding initiatives. Despite increasing use of the term, the translation of basic science discoveries into clinical practice is not straightforward. This systematic search and narrative synthesis aimed to examine factors enabling or hindering translational research from the perspective of basic and clinician scientists, a key stakeholder group in translational research, and to draw policy-relevant implications for organisations seeking to optimise translational research opportunities. Methods and Results We searched SCOPUS and Web of Science from inception until April 2015 for papers reporting scientists’ views of the factors they perceive as enabling or hindering the conduct of translational research. We screened 8,295 papers from electronic database searches and 20 papers from hand searches and citation tracking, identifying 26 studies of qualitative, quantitative or mixed method designs. We used a narrative synthesis approach and identified the following themes: 1) differing concepts of translational research 2) research processes as a barrier to translational research; 3) perceived cultural divide between research and clinical care; 4) interdisciplinary collaboration as enabling translation research, but dependent on the quality of prior and current social relationships; 5) translational research as entrepreneurial science. Across all five themes, factors enabling or hindering translational research were largely shaped by wider social, organisational, and structural factors. Conclusion To optimise translational research, policy could consider refining translational research models to better reflect scientists’ experiences, fostering greater collaboration and buy in from all types of scientists. Organisations could foster cultural change, ensuring that organisational practices and systems keep pace with the change in knowledge production brought about by the translational research agenda. PMID:27490373

Optimising Translational Research Opportunities: A Systematic Review and Narrative Synthesis of Basic and Clinician Scientists' Perspectives of Factors Which Enable or Hinder Translational Research.

PubMed

Fudge, Nina; Sadler, Euan; Fisher, Helen R; Maher, John; Wolfe, Charles D A; McKevitt, Christopher

2016-01-01

Translational research is central to international health policy, research and funding initiatives. Despite increasing use of the term, the translation of basic science discoveries into clinical practice is not straightforward. This systematic search and narrative synthesis aimed to examine factors enabling or hindering translational research from the perspective of basic and clinician scientists, a key stakeholder group in translational research, and to draw policy-relevant implications for organisations seeking to optimise translational research opportunities. We searched SCOPUS and Web of Science from inception until April 2015 for papers reporting scientists' views of the factors they perceive as enabling or hindering the conduct of translational research. We screened 8,295 papers from electronic database searches and 20 papers from hand searches and citation tracking, identifying 26 studies of qualitative, quantitative or mixed method designs. We used a narrative synthesis approach and identified the following themes: 1) differing concepts of translational research 2) research processes as a barrier to translational research; 3) perceived cultural divide between research and clinical care; 4) interdisciplinary collaboration as enabling translation research, but dependent on the quality of prior and current social relationships; 5) translational research as entrepreneurial science. Across all five themes, factors enabling or hindering translational research were largely shaped by wider social, organisational, and structural factors. To optimise translational research, policy could consider refining translational research models to better reflect scientists' experiences, fostering greater collaboration and buy in from all types of scientists. Organisations could foster cultural change, ensuring that organisational practices and systems keep pace with the change in knowledge production brought about by the translational research agenda.

Introduction to the Special Section on Epigenetics.

PubMed

Lester, Barry M; Conradt, Elisabeth; Marsit, Carmen

2016-01-01

Epigenetics provides the opportunity to revolutionize our understanding of the role of genetics and the environment in explaining human behavior, although the use of epigenetics to study human behavior is just beginning. In this introduction, the authors present the basics of epigenetics in a way that is designed to make this exciting field accessible to a wide readership. The authors describe the history of human behavioral epigenetic research in the context of other disciplines and graphically illustrate the burgeoning of research in the application of epigenetic methods and principles to the study of human behavior. The role of epigenetics in normal embryonic development and the influence of biological and environmental factors altering behavior through epigenetic mechanisms and developmental programming are discussed. Some basic approaches to the study of epigenetics are reviewed. The authors conclude with a discussion of challenges and opportunities, including intervention, as the field of human behavioral epigenetics continue to grow. © 2016 The Authors. Child Development © 2016 Society for Research in Child Development, Inc.

Division of energy biosciences: Annual report and summaries of FY 1995 activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1996-04-01

The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanisms affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicalsmore » by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes.« less

Transportation research methods : a guide to searching for funding opportunities.

DOT National Transportation Integrated Search

2017-03-01

This project developed a training methodology focused on external funding. This hands-on training presented the basics of external funding identification, teambuilding and collaborative partners, and proposal element design. Real-time searches and tu...

Translating Alcohol Research: Opportunities and Challenges.

PubMed

Batman, Angela M; Miles, Michael F

2015-01-01

Alcohol use disorder (AUD) and its sequelae impose a major burden on the public health of the United States, and adequate long-term control of this disorder has not been achieved. Molecular and behavioral basic science research findings are providing the groundwork for understanding the mechanisms underlying AUD and have identified multiple candidate targets for ongoing clinical trials. However, the translation of basic research or clinical findings into improved therapeutic approaches for AUD must become more efficient. Translational research is a multistage process of stream-lining the movement of basic biomedical research findings into clinical research and then to the clinical target populations. This process demands efficient bidirectional communication across basic, applied, and clinical science as well as with clinical practitioners. Ongoing work suggests rapid progress is being made with an evolving translational framework within the alcohol research field. This is helped by multiple interdisciplinary collaborative research structures that have been developed to advance translational work on AUD. Moreover, the integration of systems biology approaches with collaborative clinical studies may yield novel insights for future translational success. Finally, appreciation of genetic variation in pharmacological or behavioral treatment responses and optimal communication from bench to bedside and back may strengthen the success of translational research applications to AUD.

Confessions of a fungal systematist

Treesearch

D. Jean Lodge

2016-01-01

1. The Long-Term Ecological Research (LTER) program has not influenced my basic approach to science. 2. The LTER program has reinforced my approach to mentoring, and it has increased my opportunities to mentor students through the LTER-associated Research Experiences for Undergraduates Program. 3. LTER program has greatly enriched my collaborative network and expanded...

Of Mice and Meth: A New Media-Based Neuropsychopharmacology Lab to Teach Research Methods

ERIC Educational Resources Information Center

Hatch, Daniel L.; Zschau, Tony; Hays, Arthur; McAllister, Kristin; Harrison, Michelle; Cate, Kelly L.; Shanks, Ryan A.; Lloyd, Steven A.

2014-01-01

This article describes an innovative neuropsychopharmacology laboratory that can be incorporated into any research methods class. The lab consists of a set of interconnected modules centered on observations of methamphetamine-induced behavioral changes in mice and is designed to provide students with an opportunity to acquire basic skills…

Students Become Scientists at Science Skills Boot Camp | Poster

Cancer.gov

At the 2016 Science Skills Boot Camp (SSBC), a one-day training program designed for NIH summer interns with little or no prior research experience, students gathered to learn about basic research and laboratory skills. The boot camp provided a unique opportunity for interns to expand their knowledge of simple bench techniques, scientific papers, and ways to communicate their research.

Tenure Track Investigator | Center for Cancer Research

Cancer.gov

The Neuro-Oncology Branch (NOB), Center for Cancer Research (CCR) of the National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (HHS), Bethesda, MD, is actively recruiting for a tenure-track principal investigator to work in the area of immunology and/or immunotherapy.  The NOB Immunology/Immunotherapy Investigator will be tasked with forming and leading an independent research program.  This position will build the basic immunology program in the NOB and complement ongoing and planned translational research and clinical trials evaluating the effects of immunotherapy in patients with primary brain tumors.  This program will be able to access biospecimens generated from ongoing and planned immunotherapy protocols within the NOB, thus creating an opportunity to perform correlative studies to interrogate the complex biology of immunologic response, toxicity, and treatment resistance.  Demonstrated expertise in scientific inquiries in immunotherapy and/or immunology are essential, but prior work in brain tumors is not required.  This is an exciting opportunity to join a growing trans-institutional research team that promotes and supports collaborations across the basic, translational, and clinical research spectrum to develop novel therapeutics for individuals with primary central nervous system malignancies that will globally influence the field.

An opportunity: improving client services during disaster relief.

PubMed

Helferich, Omar Keith; Griggs, John E

2006-11-01

Access to current, accurate, and relevant information is mandatory for effective disaster response. In-field observations, reviews of after-action reports, and basic research indicate that this most basic of requirements is not being met. Participating disaster recovery parties, in particular environmental health agencies, lack clarity about their exact roles and lack the most basic of technological solutions that could support any given role definition. There is a need, from both cost and training perspectives, for a single, integrated solution covering risk-based routine inspections, abnormalities, and major incidents.

Preface: Sight Restoration Through Stem Cell Therapy.

PubMed

Chader, Gerald J; Young, Michael

2016-04-01

This publication presents chapters based on a meeting entitled "Sight Restoration Through Stem Cell Therapy" held on June 13, 2015, in Santa Monica, CA, sponsored by the Ocular Research Symposia Foundation (ORSF). It was chaired by Michael Young, PhD, Harvard Medical School, and Gerald Chader, PhD, University of Southern California. The mission of this publication and of the ORSF in general is to focus attention on unmet medical needs and current research opportunities in eye research with the objective of accelerating translation of research findings to effective clinical care. In the meeting, new research advances on stem cells and opportunities for their clinical application were highlighted and are recounted in the following chapters of this publication. By identifying "low-hanging fruit" (i.e., the best opportunities for successful transition of laboratory research to prevention and new treatments and cures for ocular diseases), we seek to spur funding at both the basic research and clinical levels, resulting in sight-saving and sight-restoration measures in the near future.

Microgravity: A New Tool for Basic and Applied Research in Space

NASA Technical Reports Server (NTRS)

1985-01-01

This brochure highlights selected aspects of the NASA Microgravity Science and Applications program. So that we can expand our understanding and control of physical processes, this program supports basic and applied research in electronic materials, metals, glasses and ceramics, biological materials, combustion and fluids and chemicals. NASA facilities that provide weightless environments on the ground, in the air, and in space are available to U.S. and foreign investigators representing the academic and industrial communities. After a brief history of microgravity research, the text explains the advantages and methods of performing microgravity research. Illustrations follow of equipment used and experiments preformed aboard the Shuttle and of prospects for future research. The brochure concludes be describing the program goals and the opportunities for participation.

Encouraging minority undergraduates to choose science careers: career paths survey results.

PubMed

Villarejo, Merna; Barlow, Amy E L; Kogan, Deborah; Veazey, Brian D; Sweeney, Jennifer K

2008-01-01

To explore the reasons for the dearth of minorities in Ph.D.-level biomedical research and identify opportunities to increase minority participation, we surveyed high-achieving alumni of an undergraduate biology enrichment program for underrepresented minorities. Respondents were asked to describe their career paths and to reflect on the influences that guided their career choices. We particularly probed for attitudes and experiences that influenced students to pursue a research career, as well as factors relevant to their choice between medicine (the dominant career choice) and basic science. In agreement with earlier studies, alumni strongly endorsed supplemental instruction as a mechanism for achieving excellence in basic science courses. Undergraduate research was seen as broadening by many and was transformative for half of the alumni who ultimately decided to pursue Ph.D.s in biomedical research. That group had expressed no interest in research careers at college entry and credits their undergraduate research experience with putting them on track toward a research career. A policy implication of these results is that making undergraduate research opportunities widely available to biology students (including "premed" students) in the context of a structured educational enrichment program should increase the number of minority students who choose to pursue biomedical Ph.D.s.

Transparent Conducting Oxides: Status and Opportunities in Basic Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Coutts, T. J.; Perkins, J. D.; Ginley, D.S.

1999-08-01

In this paper, we begin by discussing the historical background of transparent conducting oxides and then make some general remarks about their typical properties. This is followed by a short discussion of the desired properties for future applications (particularly photovoltaic devices). These are ambitious objectives but they provide targets for future basic research and development. Although it may be possible to obtain these properties in the laboratory, it is vital to ensure that account is taken of industrial perceptions to the development of the next generation of materials. Hence, we spend some time discussing industrial criteria. Next, we discuss keymore » physical properties that determine the macroscopic physical properties that, in turn, affect the performance of devices. Finally, we select several key topics that ought to be included in future basic research programs.« less

Back to the Basics: Cnidarians Start to Fire

PubMed Central

Bosch, Thomas C. G.; Klimovich, Alexander; Domazet-Lošo, Tomislav; Gründer, Stefan; Holstein, Thomas W.; Jékely, Gáspár; Miller, David J.; Murillo-Rincon, Andrea P.; Rentzsch, Fabian; Richards, Gemma S.; Schröder, Katja; Technau, Ulrich; Yuste, Rafael

2016-01-01

The nervous systems of cnidarians, pre-bilaterian animals that diverged close to the base of the metazoan radiation, are structurally simple and thus have great potential to inform us about basic structural and functional principles of neural circuits. Unfortunately, cnidarians have thus far been relatively intractable to electrophysiological and genetic techniques and consequently have been largely passed over by neurobiologists. However, recent advances in molecular and imaging methods are fueling a renaissance of interest in and research into cnidarians nervous systems. Here, we review current knowledge on the nervous systems of some cnidarian species and propose that researchers should seize this opportunity and undertake the study of this phylum as strategic experimental systems with great basic and translational relevance for neuroscience. PMID:28041633

The FCC: A Research Tool.

ERIC Educational Resources Information Center

Wilson, Paul

The numerous forms filed with the Federal Communications Commission (FCC) provide information about a variety of topics. Basic licensing information that is available concerns engineering, ownership, and equal employment opportunity. The FCC's broadcast bureau collects information about programing, the ascertainment of community needs, public…

Equality of Educational Opportunity: A Handbook for Research.

ERIC Educational Resources Information Center

Miller, LaMar P., Ed.; Gordon, Edmund W., Ed.

The content of this book is embedded in two historical frameworks. The first is the history of American education in which the basic underlying premise is that education is a means of achieving equality in our society. The other is the development of educational research in the United States which was founded on a deep conviction that one could…

Applying Research in Reading Instruction for Adults: First Steps for Teachers

ERIC Educational Resources Information Center

McShane, Susan

2005-01-01

Reading is the most basic of skills. Reading provides access to other skills and knowledge, facilitates life-long learning, and opens doors to opportunity. The National Institute for Literacy is authorized by the U.S. Congress to collect and disseminate information on the components of reading and the findings from scientific research. The…

New Funding Opportunity: Tissue Purchase Order Acquisitions | Office of Cancer Clinical Proteomics Research

Cancer.gov

The National Cancer Institute (NCI) is expanding its basic and translational research programs that rely heavily on sufficient availability of high quality, well annotated biospecimens suitable for use in genomic and proteomic studies.  The NCI’s overarching goal with such programs is to improve the ability to diagnose, treat, and prevent cancer.

The State of Melanoma: Challenges and Opportunities

PubMed Central

Merlino, Glenn; Herlyn, Meenhard; Fisher, David E.; Bastian, Boris C.; Flaherty, Keith T.; Davies, Michael A.; Wargo, Jennifer A.; Curiel-Lewandrowski, Clara; Weber, Michael J.; Leachman, Sancy A.; Soengas, Maria S.; McMahon, Martin; Harbour, J. William; Swetter, Susan M.; Aplin, Andrew E.; Atkins, Michael B.; Bosenberg, Marcus W.; Dummer, Reinhard; Gershenwald, Jeff; Halpern, Allan C.; Herlyn, Dorothee; Karakousis, Giorgos C.; Kirkwood, John M.; Krauthammer, Michael; Lo, Roger S.; Long, Georgina V.; McArthur, Grant; Ribas, Antoni; Schuchter, Lynn; Sosman, Jeffrey A.; Smalley, Keiran S.; Steeg, Patricia; Thomas, Nancy E.; Tsao, Hensin; Tueting, Thomas; Weeraratna, Ashani; Xu, George; Lomax, Randy; Martin, Alison; Silverstein, Steve; Turnham, Tim; Ronai, Ze’ev A.

2017-01-01

The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas—diagnosis/early detection, prevention, tumor cell dormancy (including metastasis) and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November. Each of the four groups has outlined their thoughts per the current status, challenges and opportunities in the four respective areas. The current state and immediate and long-term needs of the melanoma field, from basic research to clinical management, are presented in the following report. PMID:27087480

Clinical research: business opportunities for pharmacy-based investigational drug services.

PubMed

Marnocha, R M

1999-02-01

The application by an academic health center of business principles to the conduct of clinical research is described. Re-engineering of the infrastructure for clinical research at the University of Wisconsin and University of Wisconsin Hospital and Clinics began in 1990 with the creation of the Center for Clinical Trials (CCT) and the restructuring of the investigational drug services (IDS). Strategies to further improve the institution's clinical research activities have been continually assessed and most recently have centered on the adaptation of a business philosophy within the institution's multidisciplinary research infrastructure. Toward that end, the CCT and IDS have introduced basic business principles into operational activities. Four basic business concepts have been implemented: viewing the research protocol as a commodity, seeking payment for services rendered, tracking investments, and assessing performance. It is proposed that incorporation of these basic business concepts is not only compatible with the infrastructure for clinical research but beneficial to that infrastructure. The adaptation of a business mindset is likely to enable an academic health center to reach its clinical research goals.

Expansion of Economic Base Analysis: Labor Availability in North-Central New Mexico. Research Report No. 264.

ERIC Educational Resources Information Center

Carruthers, Garrey E.; And Others

Estimates of the number of persons willing to commute, at alternative wage rates, to job opportunities in north-central New Mexico have been based on results of basic research in the region and 1970 census data. Expressed willingness to commute and socio-economic characteristics data were accumulated from a regional survey of 643 households. The…

Students Become Scientists at Science Skills Boot Camp | Poster

Cancer.gov

At the 2016 Science Skills Boot Camp (SSBC), a one-day training program designed for NIH summer interns with little or no prior research experience, students gathered to learn about basic research and laboratory skills. The boot camp provided a unique opportunity for interns to expand their knowledge of simple bench techniques, scientific papers, and ways to communicate their

The poverty-related neglected diseases: Why basic research matters.

PubMed

Hotez, Peter J

2017-11-01

Together, malaria and the neglected tropical diseases (NTDs) kill more than 800,000 people annually, while creating long-term disability in millions more. International support for mass drug administration, bed nets, and other preventive measures has resulted in huge public health gains, while support for translational research is leading to the development of some new neglected disease drugs, diagnostics, and vaccines. However, funding for basic science research has not kept up, such that we are missing opportunities to create a more innovative pipeline of control tools for parasitic and related diseases. There is an urgent need to expand basic science approaches for neglected diseases, especially in the areas of systems biology and immunology; ecology, evolution, and mathematical biology; functional and comparative OMICs; gene editing; expanded use of model organisms; and a new single-cell combinatorial indexing RNA sequencing approach. The world's poor deserve access to innovation for neglected diseases. It should be considered a fundamental human right.

Qualitative Research in Palliative Care: Applications to Clinical Trials Work.

PubMed

Lim, Christopher T; Tadmor, Avia; Fujisawa, Daisuke; MacDonald, James J; Gallagher, Emily R; Eusebio, Justin; Jackson, Vicki A; Temel, Jennifer S; Greer, Joseph A; Hagan, Teresa; Park, Elyse R

2017-08-01

While vast opportunities for using qualitative methods exist within palliative care research, few studies provide practical advice for researchers and clinicians as a roadmap to identify and utilize such opportunities. To provide palliative care clinicians and researchers descriptions of qualitative methodology applied to innovative research questions relative to palliative care research and define basic concepts in qualitative research. Body: We describe three qualitative projects as exemplars to describe major concepts in qualitative analysis of early palliative care: (1) a descriptive analysis of clinician documentation in the electronic health record, (2) a thematic content analysis of palliative care clinician focus groups, and (3) a framework analysis of audio-recorded encounters between patients and clinicians as part of a clinical trial. This study provides a foundation for undertaking qualitative research within palliative care and serves as a framework for use by other palliative care researchers interested in qualitative methodologies.

Patient Engagement in Kidney Research: Opportunities and Challenges Ahead

PubMed Central

Molnar, Amber O.; Barua, Moumita; Konvalinka, Ana; Schick-Makaroff, Kara

2017-01-01

Purpose of Review: Patient engagement in research is increasingly recognized as an important component of the research process and may facilitate translation of research findings. To heighten awareness on this important topic, this review presents opportunities and challenges of patient engagement in research, drawing on specific examples from 4 areas of Canadian kidney research conducted by New Investigators in the Kidney Research Scientist Core Education and National Training (KRESCENT) Program. Sources of Information: Research expertise, published reports, peer-reviewed articles, and research funding body websites. Methods: In this review, the definition, purpose, and potential benefits of patient engagement in research are discussed. Approaches toward patient engagement that may help with translation and uptake of research findings into clinical practice are highlighted. Opportunities and challenges of patient engagement are presented in both basic science and clinical research with the following examples of kidney research: (1) precision care in focal and segmental glomerulosclerosis, (2) systems biology approaches to improve management of chronic kidney disease and enhance kidney graft survival, (3) reducing the incidence of suboptimal dialysis initiation, and (4) use of patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) in kidney practice. Key Findings: Clinical research affords more obvious opportunities for patient engagement. The most obvious step at which to engage patients is in the setting of research priorities. Engagement at all stages of the research cycle may prove to be more challenging, and requires a detailed plan, along with funds and infrastructure to ensure that it is not merely tokenistic. Basic science research is several steps removed from the clinical application and involves complex scientific concepts, which makes patient engagement inherently more difficult. Limitations: This is a narrative review of the literature that has been partly influenced by the perspectives and experiences of the authors and focuses on research conducted by the authors. The evidence base to support the suggested benefits of patient engagement in research is currently limited. Implications: The formal incorporation of patients’ priorities, perspectives, and experiences is now recognized as a key component of the research process. If patients and researchers are able to effectively work together, this could enhance research quality and efficiency. To effectively engage patients, proper infrastructure and dedicated funding are needed. Going forward, a rigorous evaluation of patient engagement strategies and their effectiveness will be needed. PMID:29225906

Patient Engagement in Kidney Research: Opportunities and Challenges Ahead.

PubMed

Molnar, Amber O; Barua, Moumita; Konvalinka, Ana; Schick-Makaroff, Kara

2017-01-01

Patient engagement in research is increasingly recognized as an important component of the research process and may facilitate translation of research findings. To heighten awareness on this important topic, this review presents opportunities and challenges of patient engagement in research, drawing on specific examples from 4 areas of Canadian kidney research conducted by New Investigators in the Kidney Research Scientist Core Education and National Training (KRESCENT) Program. Research expertise, published reports, peer-reviewed articles, and research funding body websites. In this review, the definition, purpose, and potential benefits of patient engagement in research are discussed. Approaches toward patient engagement that may help with translation and uptake of research findings into clinical practice are highlighted. Opportunities and challenges of patient engagement are presented in both basic science and clinical research with the following examples of kidney research: (1) precision care in focal and segmental glomerulosclerosis, (2) systems biology approaches to improve management of chronic kidney disease and enhance kidney graft survival, (3) reducing the incidence of suboptimal dialysis initiation, and (4) use of patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) in kidney practice. Clinical research affords more obvious opportunities for patient engagement. The most obvious step at which to engage patients is in the setting of research priorities. Engagement at all stages of the research cycle may prove to be more challenging, and requires a detailed plan, along with funds and infrastructure to ensure that it is not merely tokenistic. Basic science research is several steps removed from the clinical application and involves complex scientific concepts, which makes patient engagement inherently more difficult. This is a narrative review of the literature that has been partly influenced by the perspectives and experiences of the authors and focuses on research conducted by the authors. The evidence base to support the suggested benefits of patient engagement in research is currently limited. The formal incorporation of patients' priorities, perspectives, and experiences is now recognized as a key component of the research process. If patients and researchers are able to effectively work together, this could enhance research quality and efficiency. To effectively engage patients, proper infrastructure and dedicated funding are needed. Going forward, a rigorous evaluation of patient engagement strategies and their effectiveness will be needed.

Collaborating and sharing data in epilepsy research.

PubMed

Wagenaar, Joost B; Worrell, Gregory A; Ives, Zachary; Dümpelmann, Matthias; Matthias, Dümpelmann; Litt, Brian; Schulze-Bonhage, Andreas

2015-06-01

Technological advances are dramatically advancing translational research in Epilepsy. Neurophysiology, imaging, and metadata are now recorded digitally in most centers, enabling quantitative analysis. Basic and translational research opportunities to use these data are exploding, but academic and funding cultures prevent this potential from being realized. Research on epileptogenic networks, antiepileptic devices, and biomarkers could progress rapidly if collaborative efforts to digest this "big neuro data" could be organized. Higher temporal and spatial resolution data are driving the need for novel multidimensional visualization and analysis tools. Crowd-sourced science, the same that drives innovation in computer science, could easily be mobilized for these tasks, were it not for competition for funding, attribution, and lack of standard data formats and platforms. As these efforts mature, there is a great opportunity to advance Epilepsy research through data sharing and increase collaboration between the international research community.

FY 2014 LDRD Annual Report Project Summaries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tomchak, Dena

The FY 2014 Laboratory Directed Research and Development (LDRD) Annual Report is a compendium of the diverse research performed to develop and ensure the INL's technical capabilities can support future DOE missions and national research priorities. LDRD is essential to INL - it provides a means for the laboratory to pursue novel scientific and engineering research in areas that are deemed too basic or risky for programmatic investments. This research enahnces technical capabilities at the laboratory, providing scientific and engineering staff with opportunities for skill building and partnership development.

The Rural School Principalship: Unique Challenges, Opportunities.

ERIC Educational Resources Information Center

Hill, Jonathan

1993-01-01

Presents findings based on author's research and experience as principal in California's Mojave Desert. Five basic characteristics distinguish the rural principalship: lack of an assistant principal or other support staff; assumption of other duties, including central office tasks, teaching, or management of another site; less severe student…

New Skills for a New Economy: Adult Education's Key Role in Sustaining Economic Growth and Expanding Opportunity.

ERIC Educational Resources Information Center

Comings, John; Sum, Andrew; Uvin, Johan

The role of adult education in sustaining economic growth and expanding opportunity in Massachusetts was explored. The analysis focused on the new basic skills needed for a new economy, groups lacking the new basic skills, the demand for adult basic education (ABE), funding for ABE, building basic skills through adult education, ABE's costs and…

Industrial applications of the microgravity environment

NASA Technical Reports Server (NTRS)

1988-01-01

Opportunities for commercialization of the microgravity environment will depend upon the success of basic research projects performed in space. Significant demands for manufacturing opportunities are unlikely in the near term. The microgravity environment is to be considered primarily as a tool for research and secondarily as a manufacturing site. This research tool is unique, valuable, and presently available to U.S. investigators only through resources provided by NASA. The United States has an obligation to facilitate corporate research, maintain a flexible international policy, foster use of and assure access to a wide variety of facilities, and develop a posture of national and international leadership in and stewardship of research and materials processing in the microgravity environment. The National Research Council's Committee on Industrial Applications of the Microgravity Environment recommends six actions that strengthen this posture, including the formation of an authoritative organization to oversee the implementation of a program of microgravity research and its industrial applications.

Soil science and geology: Connects, disconnects and new opportunities in geoscience education

USGS Publications Warehouse

Landa, E.R.

2004-01-01

Despite historical linkages, the fields of geology and soil science have developed along largely divergent paths in the United States during much of the mid- to late- twentieth century. The shift in recent decades within both disciplines to greater emphasis on environmental quality issues and a systems approach has created new opportunities for collaboration and cross-training. Because of the importance of the soil as a dynamic interface between the hydrosphere, biosphere, atmosphere, and lithosphere, introductory and advanced soil science classes are now being taught in a number of earth and environmental science departments. The National Research Council's recent report, Basic Research Opportunities in Earth Science, highlights the soil zone as part of the land surface-to-groundwater "critical zone" requiring additional investigation. To better prepare geology undergraduates to deal with complex environmental problems, their training should include a fundamental understanding of the nature and properties of soils. Those undergraduate geology students with an interest in this area should be encouraged to view soil science as a viable earth science specialty area for graduate study. Summer internships such as those offered by the National Science Foundation-funded Integrative Graduate Education, Research, and Training (IGERT) programs offer geology undergraduates the opportunity to explore research and career opportunities in soil science.

Chinese health care system and clinical epidemiology

PubMed Central

Sun, Yuelian; Gregersen, Hans; Yuan, Wei

2017-01-01

China has gone through a comprehensive health care insurance reform since 2003 and achieved universal health insurance coverage in 2011. The new health care insurance system provides China with a huge opportunity for the development of health care and medical research when its rich medical resources are fully unfolded. In this study, we review the Chinese health care system and its implication for medical research, especially within clinical epidemiology. First, we briefly review the population register system, the distribution of the urban and rural population in China, and the development of the Chinese health care system after 1949. In the following sections, we describe the current Chinese health care delivery system and the current health insurance system. We then focus on the construction of the Chinese health information system as well as several existing registers and research projects on health data. Finally, we discuss the opportunities and challenges of the health care system in regard to clinical epidemiology research. China now has three main insurance schemes. The Urban Employee Basic Medical Insurance (UEBMI) covers urban employees and retired employees. The Urban Residence Basic Medical Insurance (URBMI) covers urban residents, including children, students, elderly people without previous employment, and unemployed people. The New Rural Cooperative Medical Scheme (NRCMS) covers rural residents. The Chinese Government has made efforts to build up health information data, including electronic medical records. The establishment of universal health care insurance with linkage to medical records will provide potentially huge research opportunities in the future. However, constructing a complete register system at a nationwide level is challenging. In the future, China will demand increased capacity of researchers and data managers, in particular within clinical epidemiology, to explore the rich resources. PMID:28356772

An organismal view of dendrochronology

Treesearch

Kevin T. Smith

2008-01-01

An organism is the most basic unit of independent life. The tree-ring record is defined by organismal processes. Dendrochronology contributes to investigations far removed from organismal biology, e.g., archeology, climatology, disturbance ecology, etc. The increasing integration of dendrochronology into a diverse research community suggests an opportunity for a brief...

Fundulus as the Premier Teleost Model in Environmental Biology: Opportunities for New Insights Using Genomics

EPA Science Inventory

A strong foundation of basic and applied research documents that the estuarine fish Fundulus heteroclitus and related species are unique laboratory and field models for understanding how individuals and populations interact with their environment. In this paper we summarize an ex...

Teaching Data Sampling in the Communication Theory Course.

ERIC Educational Resources Information Center

Cassella, Michele; Mason, Gail

The basic communication theory course offered at Central Michigan University is designed to provide students with an understanding of fundamental concepts and terminology, and to expose them to theory and research in communication. The course gives students the opportunity to engage in simulations and other in-class activities, thus making…

Centers and Institutes for the "Resource-Challenged" Catholic University

ERIC Educational Resources Information Center

Sanders, Susan M.; Clough, Joy

2011-01-01

Founded in 2001, the Center for Religion and Public Discourse at Saint Xavier University, Chicago, illustrates how centers and institutes can express Catholic identity and serve the university community and society by providing opportunities for thoughtful and civil discourse. Although the Center does not currently support basic research or fund…

49 CFR Appendix to Part 380 - LCV Driver Training Programs, Required Knowledge and Skills

Code of Federal Regulations, 2012 CFR

2012-10-01

...-wheel training designed to provide an opportunity to develop the skills outlined under the Proficiency... Maneuvers; and Turning, Steering and Tracking units. A series of basic exercises is practiced at off-highway... Security, Transportation Security Administration; the U.S. Department of Transportation, Research and...

49 CFR Appendix to Part 380 - LCV Driver Training Programs, Required Knowledge and Skills

Code of Federal Regulations, 2011 CFR

2011-10-01

...-wheel training designed to provide an opportunity to develop the skills outlined under the Proficiency... Maneuvers; and Turning, Steering and Tracking units. A series of basic exercises is practiced at off-highway... Security, Transportation Security Administration; the U.S. Department of Transportation, Research and...

49 CFR Appendix to Part 380 - LCV Driver Training Programs, Required Knowledge and Skills

Code of Federal Regulations, 2010 CFR

2010-10-01

...-wheel training designed to provide an opportunity to develop the skills outlined under the Proficiency... Maneuvers; and Turning, Steering and Tracking units. A series of basic exercises is practiced at off-highway... Security, Transportation Security Administration; the U.S. Department of Transportation, Research and...

Promoting Healthy Behaviors in Children: Applying Ignatian Values in Schools

ERIC Educational Resources Information Center

Schwartz, Misty; Lauglin, Ann; Connelly, Susan; Potthoff, Meghan; Synowiecki, Barbara; Yager, Amy

2013-01-01

An innovative partnership between a college of nursing and local parochial schools provided opportunities for nursing students to offer basic health promotion and disease prevention services, provide health education, and participate in a service-learning, research endeavor. This partnership provided the nursing school with the ability to…

High School Students' Learning and Perceptions of Phylogenetics of Flowering Plants

ERIC Educational Resources Information Center

Bokor, Julie R.; Landis, Jacob B.; Crippen, Kent J.

2014-01-01

Basic phylogenetics and associated "tree thinking" are often minimized or excluded in formal school curricula. Informal settings provide an opportunity to extend the K-12 school curriculum, introducing learners to new ideas, piquing interest in science, and fostering scientific literacy. Similarly, university researchers participating in…

Postdoctoral Positions and Career Growth

NASA Astrophysics Data System (ADS)

Manka, R. H.

2001-12-01

Career choices begin to diverge at the time the doctorate is received. A variety of career options are available to pursue including positions in academia, government, and industry as well as non-traditional services. A postdoctoral appointment is worth considering as preparation for a career in academia or basic research. The postdoctoral appointment can expand the recent graduate's background and broaden their scientific perspective and reputation. Postdoctoral experience may even be essential to be competitive for some faculty and research laboratory appointments. However, there is a wide range of postdoctoral choices to consider. There are many opportunities for postdoctoral appointments in universities, and emerging opportunities in some corporate laboratories. We will mention opportunities in federal laboratories such as the National Research Council programs in NASA, NOAA, EPA, and the Dept. of Defense, which are open to U.S. citizens and in some cases to non-U.S. applicants, to pursue research in all areas of the Earth and space sciences. And there are exciting new interdisciplinary programs such as the NASA Astrobiology Institute, as well as international opportunities including the von Humboldt fellowships in Germany and similar programs elsewhere in Europe, Japan, and other countries.

Laboratory Directed Research and Development FY-10 Annual Report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dena Tomchak

2011-03-01

The FY 2010 Laboratory Directed Research and Development (LDRD) Annual Report is a compendium of the diverse research performed to develop and ensure the INL's technical capabilities can support the future DOE missions and national research priorities. LDRD is essential to the INL -- it provides a means for the laboratory to pursue novel scientific and engineering research in areas that are deemed too basic or risky for programmatic investments. This research enhances technical capabilities at the laboratory, providing scientific and engineering staff with opportunities for skill building and partnership development.

malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication

PubMed Central

2017-01-01

Basic science holds enormous power for revealing the biological mechanisms of disease and, in turn, paving the way toward new, effective interventions. Recognizing this power, the 2011 Research Agenda for Malaria Eradication included key priorities in fundamental research that, if attained, could help accelerate progress toward disease elimination and eradication. The Malaria Eradication Research Agenda (malERA) Consultative Panel on Basic Science and Enabling Technologies reviewed the progress, continuing challenges, and major opportunities for future research. The recommendations come from a literature of published and unpublished materials and the deliberations of the malERA Refresh Consultative Panel. These areas span multiple aspects of the Plasmodium life cycle in both the human host and the Anopheles vector and include critical, unanswered questions about parasite transmission, human infection in the liver, asexual-stage biology, and malaria persistence. We believe an integrated approach encompassing human immunology, parasitology, and entomology, and harnessing new and emerging biomedical technologies offers the best path toward addressing these questions and, ultimately, lowering the worldwide burden of malaria. PMID:29190277

Incorporation of Novel MRI and Biomarkers into Prostate Cancer Active Surveillance Risk Assessment

DTIC Science & Technology

2016-09-01

that are integral in the preparation for a career in clinical research. These goals are 1) training in T1 translational research; 2) training in the...Texas. In addition to basic mentoring tasks, we have identified four sources of mentorship in particular to my career , which include opportunities at...clinical schedule for protected time to ensure I meet the goals of my grant and career development. Research: We have successfully implemented

Extremity war injuries: collaborative efforts in research, host nation care, and disaster preparedness.

PubMed

Pollak, Andrew N; Ficke, Col James R

2010-01-01

The fourth annual Extremity War Injuries (EWI) Symposium addressed ongoing challenges and opportunities in the management of combat-related musculoskeletal injury. The symposium, which also examined host-nation care and disaster preparedness and response, defined opportunities for synergy between several organizations with similar missions and goals. Within the Department of Defense, the Orthopaedic Extremity Trauma Research Program (OETRP) has funded basic research related to a series of protocols first identified and validated at prior EWI symposia. A well-funded clinical research arm of OETRP has been developed to help translate and validate research advances from each of the protocols. The Armed Forces Institute for Regenerative Medicine, a consortium of academic research institutions, employs a tissue-engineering approach to EWI challenges, particularly with regard to tissue loss. Programs within the National Institute of Arthritis and Musculoskeletal and Skin Diseases and throughout the National Institutes of Health have also expanded tissue-engineering efforts by emphasizing robust mechanistic basic science programs. Much of the clinical care delivered by US military medical personnel and nongovernmental agencies has been to host-nation populations; coordinating delivery to maximize the number of injured who receive care requires understanding of the breadth and scope of resources available within the war zone. Similarly, providing the most comprehensive care to the greatest number of injured in the context of domestic mass casualty requires discussion and planning by all groups involved.

Currency arbitrage detection using a binary integer programming model

NASA Astrophysics Data System (ADS)

Soon, Wanmei; Ye, Heng-Qing

2011-04-01

In this article, we examine the use of a new binary integer programming (BIP) model to detect arbitrage opportunities in currency exchanges. This model showcases an excellent application of mathematics to the real world. The concepts involved are easily accessible to undergraduate students with basic knowledge in Operations Research. Through this work, students can learn to link several types of basic optimization models, namely linear programming, integer programming and network models, and apply the well-known sensitivity analysis procedure to accommodate realistic changes in the exchange rates. Beginning with a BIP model, we discuss how it can be reduced to an equivalent but considerably simpler model, where an efficient algorithm can be applied to find the arbitrages and incorporate the sensitivity analysis procedure. A simple comparison is then made with a different arbitrage detection model. This exercise helps students learn to apply basic Operations Research concepts to a practical real-life example, and provides insights into the processes involved in Operations Research model formulations.

Training fellows in paediatric cardiology: the Harvard experience.

PubMed

Brown, David W; Allan, Catherine K; Newburger, Jane W

2016-12-01

The Fellowship Program of the Department of Cardiology at Boston Children's Hospital seeks to train academically oriented leaders in clinical care and laboratory and clinical investigation of cardiovascular disease in the young. The core clinical fellowship involves 3 years in training, comprising 24 months of clinical rotations and 12 months of elective and research experience. Trainees have access to a vast array of research opportunities - clinical, basic, and translational. Clinical fellows interested in basic science may reverse the usual sequence and start their training in the laboratory, deferring clinical training for 1 or more years. An increasing number of clinical trainees apply to spend a fourth year as a senior fellow in one of the subspecialty areas of paediatric cardiology. From the founding of the Department to the present, we have maintained a fundamental and unwavering commitment to training and education in clinical care and research in basic science and clinical investigation, as well as to the training of outstanding young clinicians and investigators.

Beyond 100 Tesla: Scientific experiments using single-turn coils

NASA Astrophysics Data System (ADS)

Portugall, Oliver; Solane, Pierre Yves; Plochocka, Paulina; Maude, Duncan K.; Nicholas, Robin J.

2013-01-01

Current opportunities and recent examples for research in magnetic fields well above 100 T using single-turn coils are discussed. After a general introduction into basic principles and technical constraints associated with the generation of Megagauss fields we discuss data obtained at the LNCMI Toulouse, where such fields are routinely used for scientific applications.

Opportunities for joint FPL and VTT research.

Treesearch

Theodore Wegner

2010-01-01

Openness, collaboration and sharing of information in developing the basic underlying, precompetitive science and technology for areas of emerging importance to the forest products sectors of the US and Finland are expected to provide synergistic benefits and allow for more creative problem solving. There appear to be a number of common interests with respect to...

Non-Formal Education for Rural Development: Strengthening Learning Opportunities for Children and Youth. Interim Report.

ERIC Educational Resources Information Center

United Nations Economic and Social Council, New York, NY.

This interim report, commissioned by UNICEF, emphasizes the value of nonformal educational programs to educationally deprived rural children and youth in developing countries. The first set of basic findings and recommendations arising from this extensive international research study is presented. Organized into five chapters, the text includes…

Young Children's Drawings as Related to Basic Communication Skills. Research Monograph No. 31.

ERIC Educational Resources Information Center

de Kane, Frances Pizzini-Zepeda

The influence of graphic expression activities on kindergarten children's oral language expression was investigated. It was hypothesized that, regardless of the sex, race, or socioeconomic status (SES) of the subjects, children provided with an opportunity to express themselves graphically would talk more about a prior experience than children who…

High Tech, Low Tech and Education. Sociology of the School.

ERIC Educational Resources Information Center

Watkins, Peter

Designed to provide a link between academic thought and research and the practice of teaching, this monograph explores the appropriate educational response to technological change. The central argument of this study is that future job opportunities will lie essentially with low tech jobs, i.e., traditional, basic, industrial jobs, rather than the…

The Role of Professional Development in Bridging Research and Practice in Adult Literacy and Basic Education

ERIC Educational Resources Information Center

Smith, Cristine

2016-01-01

In this brief article, Cristine Smith discusses the development and use of professional development activities at the national, state and local program level. Professional development systems and funding exist in every state, and the Workforce Innovation and Opportunity Act (WIOA) has prioritized high-quality professional development for…

Currency Arbitrage Detection Using a Binary Integer Programming Model

ERIC Educational Resources Information Center

Soon, Wanmei; Ye, Heng-Qing

2011-01-01

In this article, we examine the use of a new binary integer programming (BIP) model to detect arbitrage opportunities in currency exchanges. This model showcases an excellent application of mathematics to the real world. The concepts involved are easily accessible to undergraduate students with basic knowledge in Operations Research. Through this…

Next Generation Scientists - Creating opportunities for high school students through astronomical research

NASA Astrophysics Data System (ADS)

Kelly, Madeline; Cebulla, Hannah; Powers, Lynn

2015-01-01

Through various opportunities and experiences with extracurricular scientific research, primarily astronomical research with programs like NASA/IPAC Teacher Archive Research Project (NITARP), and the Mars Exploration Student Data Teams (MESDT), we have noticed a change in our learning style, career path, and general outlook on the scientific community that we strongly believe could also be added to the lives of many other high school students given similar opportunities. The purpose of our poster is to emphasize the importance of granting high school students opportunities to explore different styles and methods of learning. We believe that although crucial, a basic high school education is not enough to expose young adults to the scientific community and create enough interest for a career path. As a result, we wish to show that more of these programs and opportunities should be offered to a greater number of students of all ages, allowing them to explore their passions, develop their understanding of different fields, and determine the paths best suited to their interests. Within our poster, we will emphasize how these programs have specifically impacted our lives, what we hope to see in the future, and how we hope to attain the growth of such opportunities. We include such proposals as; increasing outreach programs, expanding the exposure of young students to the sciences, both in the classroom and out, allowing high school students to participate in active scientific research, and involving students in hands-on activities/experiments within school clubs, the classroom, at home, or at local events. Spreading these opportunities to directly interact with the sciences in similar manners as that of professional scientists will allow students to discover their interests, realize what being a scientist truly entails, and allow them to take the first steps into following their career paths.

Opportunities and challenges of current electrophysiology research: a plea to establish 'translational electrophysiology' curricula.

PubMed

Lau, Dennis H; Volders, Paul G A; Kohl, Peter; Prinzen, Frits W; Zaza, Antonio; Kääb, Stefan; Oto, Ali; Schotten, Ulrich

2015-05-01

Cardiac electrophysiology has evolved into an important subspecialty in cardiovascular medicine. This is in part due to the significant advances made in our understanding and treatment of heart rhythm disorders following more than a century of scientific discoveries and research. More recently, the rapid development of technology in cellular electrophysiology, molecular biology, genetics, computer modelling, and imaging have led to the exponential growth of knowledge in basic cardiac electrophysiology. The paradigm of evidence-based medicine has led to a more comprehensive decision-making process and most likely to improved outcomes in many patients. However, implementing relevant basic research knowledge in a system of evidence-based medicine appears to be challenging. Furthermore, the current economic climate and the restricted nature of research funding call for improved efficiency of translation from basic discoveries to healthcare delivery. Here, we aim to (i) appraise the broad challenges of translational research in cardiac electrophysiology, (ii) highlight the need for improved strategies in the training of translational electrophysiologists, and (iii) discuss steps towards building a favourable translational research environment and culture. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

Communication training for centre-based carers of children with severe or profound disabilities in the Western Cape, South Africa.

PubMed

Geiger, Martha

2012-01-01

The purpose of this paper is to provide a preliminary, qualitative review of an approach to training centre-based carers in supporting basic communication development and providing communication opportunities for the children with severe and profound disabilities in their care. In South Africa, these children are often the most neglected in terms of planning and providing appropriate interventions. For those with severe communication disabilities, an additional lack is in the area of the basic human right to meaningful interactions and communication. Sustainable strategies to provide opportunities for basic communication development of these children are urgently sought. Several effective international and local parent training programmes have been developed, but the urgent need remains to train centre-based carers who are taking care of groups of diversely disabled children in severely under-resourced settings . Non-profit organisations (NPOs) have been exploring practical centre-based approaches to skills sharing in physical rehabilitation, activities for daily living, feeding and support for basic communication development. As a freelance speech therapist contracted by four NPOs to implement hands-on training in basic communication for centre-based carers of non-verbal children, the author describes a training approach that evolved over three years, in collaboration with the carers and centre managements. Implications for training (for speech therapists and for community-based rehabilitation workers) and for further research are identified.

Independent Research and Independent Exploratory Development at the Navy Personnel Research and Development Center--Fiscal Year 1984.

DTIC Science & Technology

1985-04-01

decision aids consider the cognitive skills of human operators. Data are required on the kinds of decision strategies they invoke, their limitations in...basic electronics, memory for procedural tasks, and career-role learning by officers. Computerized decision aids for surveillance tasks and opportunities...of Navy retention incentives. Computerized aids for plain English in military documents and for tactical action officer training were also developed in

RECOPE: How to succeed in bringing ideas from academia to market without compromising ingenuity.

PubMed

Gaymalov, Zagit; Kabanov, Alexander

2017-04-01

Translation of biomedical technology originated in academia to the market is hindered by lack of consideration of market needs and commercialization pathways that leads academic research away from the market, leaving the public without long-awaited cures. Here we describe Reverse Conceptual Product Engineering (RECOPE), an approach applied in academic setting early in the course of the research project to facilitate biomedical research translation from bench to bedside. By using expertise of diverse set of biomedical professionals and trainees to solve a problem, RECOPE helps to make research goals more relevant to the society needs and translatable in a long-term perspective. Through the use of RECOPE one can critically reassess research design and translational potential and identify new market opportunities. RECOPE also provides for considerable educational opportunities to pre- and post-doctoral trainees. Adoption of RECOPE as a basic to for research design education will have a noticeable impact on academic research. Copyright © 2016 Elsevier Inc. All rights reserved.

Preface: The aging eye: normal changes, age-related diseases, and sight-saving approaches.

PubMed

Chader, Gerald J; Taylor, Allen

2013-12-13

This volume presents articles based on a workshop held June 14 to 16, 2013 in Rancho Palos Verde, CA sponsored by the Ocular Research Symposia Foundation (ORSF). The mission of the ORSF is to focus attention on unmet needs and current research opportunities in eye research with the objective of accelerating translation of research findings to effective clinical care. In this workshop, the subject of the "The Aging Eye" was addressed, including the prevalence of eye diseases in aging and the economic burden imposed by these diseases. New research work was highlighted on the genetics, biology, biochemistry, neurochemistry, and the impact of nutrition and the environment on function in the older eye. By identifying "low-hanging fruit" (i.e., the best opportunities for successful transition of laboratory research for the prevention of and new treatments and cures for ocular diseases), we seek to spur funding at both the basic research and clinical levels, resulting in sight-saving and sight-restoration measures in the near future.

Challenges and Opportunities for Exploring Patient-Level Data

PubMed Central

Lopes, Pedro; Silva, Luis Bastião; Oliveira, José Luis

2015-01-01

The proper exploration of patient-level data will pave the way towards personalised medicine. To better assess the state of the art in this field we identify the challenges and uncover the opportunities for the exploration of patient-level data through the review of well-known initiatives and projects focusing on the exploration of patient-level data. These cover a broad array of topics, from genomics to patient registries up to rare diseases research, among others. For each, we identified basic goals, involved partners, defined strategies and key technological and scientific outcomes, establishing the foundation for our analysis framework with four pillars: control, sustainability, technology, and science. Substantial research outcomes have been produced towards the exploration of patient-level data. The potential behind these data will be essential to realise the personalised medicine premise in upcoming years. Hence, relevant stakeholders continually push forward new developments in this domain, bringing novel opportunities that are ripe for exploration. Despite last decade's translational research advances, personalised medicine is still far from being a reality. Patients' data underlying potential goes beyond daily clinical practice. There are miscellaneous challenges and opportunities open for the exploration of these data by academia and business stakeholders. PMID:26504779

Future Directions of Supersonic Combustion Research: Air Force/NASA Workshop on Supersonic Combustion

NASA Technical Reports Server (NTRS)

Tishkoff, Julian M.; Drummond, J. Philip; Edwards, Tim; Nejad, Abdollah S.

1997-01-01

The Air Force Office of Scientific Research, the Air Force Wright Laboratory Aero Propulsion and Power Directorate, and the NASA Langley Research Center held a joint supersonic combustion workshop on 14-16 May 1996. The intent of this meeting was to: (1) examine the current state-of-the-art in hydrocarbon and/or hydrogen fueled scramjet research; (2) define the future direction and needs of basic research in support of scramjet technology; and (3) when appropriate, help transition basic research findings to solve the needs of developmental engineering programs in the area of supersonic combustion and fuels. A series of topical sessions were planned. Opening presentations were designed to focus and encourage group discussion and scientific exchange. The last half-day of the workshop was set aside for group discussion of the issues that were raised during the meeting for defining future research opportunities and directions. The following text attempts to summarize the discussions that took place at the workshop.

Challenges and Opportunities in Interdisciplinary Materials Research Experiences for Undergraduates

NASA Astrophysics Data System (ADS)

Vohra, Yogesh; Nordlund, Thomas

2009-03-01

The University of Alabama at Birmingham (UAB) offer a broad range of interdisciplinary materials research experiences to undergraduate students with diverse backgrounds in physics, chemistry, applied mathematics, and engineering. The research projects offered cover a broad range of topics including high pressure physics, microelectronic materials, nano-materials, laser materials, bioceramics and biopolymers, cell-biomaterials interactions, planetary materials, and computer simulation of materials. The students welcome the opportunity to work with an interdisciplinary team of basic science, engineering, and biomedical faculty but the challenge is in learning the key vocabulary for interdisciplinary collaborations, experimental tools, and working in an independent capacity. The career development workshops dealing with the graduate school application process and the entrepreneurial business activities were found to be most effective. The interdisciplinary university wide poster session helped student broaden their horizons in research careers. The synergy of the REU program with other concurrently running high school summer programs on UAB campus will also be discussed.

Benefits of an inclusive US education system.

PubMed

Gantt, Elisabeth

2013-01-01

Presented is a historical perspective of one scientist's journey from war-torn Europe to the opportunities presented by a flexible US educational system. It celebrates the opening of the science establishment that began in the 1950s and its fostering of basic research, and recognizes individuals who were instrumental in guiding the author's education as well as those with whom she later participated in collaborative algal plant research. The initial discovery and later elucidation of phycobilisome structure are elaborated, including the structural connection with photosystem II. Furthermore, she summarizes some of her laboratory's results on carotenoids and its exploration of the isoprenoid pathway in cyanobacteria. Finally, she comments on the gender gap and how her generation benefited when opportunities for women scientists were enlarged.

Back to the Basics: Cnidarians Start to Fire.

PubMed

Bosch, Thomas C G; Klimovich, Alexander; Domazet-Lošo, Tomislav; Gründer, Stefan; Holstein, Thomas W; Jékely, Gáspár; Miller, David J; Murillo-Rincon, Andrea P; Rentzsch, Fabian; Richards, Gemma S; Schröder, Katja; Technau, Ulrich; Yuste, Rafael

2017-02-01

The nervous systems of cnidarians, pre-bilaterian animals that diverged close to the base of the metazoan radiation, are structurally simple and thus have great potential to reveal fundamental principles of neural circuits. Unfortunately, cnidarians have thus far been relatively intractable to electrophysiological and genetic techniques and consequently have been largely passed over by neurobiologists. However, recent advances in molecular and imaging methods are fueling a renaissance of interest in and research into cnidarians nervous systems. Here, we review current knowledge on the nervous systems of cnidarian species and propose that researchers should seize this opportunity and undertake the study of members of this phylum as strategic experimental systems with great basic and translational relevance for neuroscience. Copyright © 2016 Elsevier Ltd. All rights reserved.

The Politics, Policies and Progress of Basic Education in Sri Lanka. CREATE Pathways to Access. Research Monograph No. 38

ERIC Educational Resources Information Center

Little, Angela W.

2010-01-01

Sri Lanka is hailed internationally for her achievements in literacy, access to education and equality of educational opportunity. However, progress has not been straightforward due to the complex interactions between politics, policy formulation, and the implementation of reforms. This dynamic process has often led to contradictory outcomes. This…

The Cooperative Approach in Rural Development. A National Strategy and Program Design.

ERIC Educational Resources Information Center

Kelly, Rita Mae

Building upon the body of knowledge re: rural cooperatives generated by the Office of Economic Opportunity and its research and demonstration programs, this paper proposes a design for a national program of Federal support for cooperatives serving the rural poor. Specifically, this paper presents: (1) the basic situation of the rural poor and the…

The Teaching of the Code of Ethics and Standard Practices for Texas Educator Preparation Programs

ERIC Educational Resources Information Center

Davenport, Marvin; Thompson, J. Ray; Templeton, Nathan R.

2015-01-01

The purpose of this descriptive quantitative research study was to answer three basic informational questions: (1) To what extent ethics training, as stipulated in Texas Administrative Code Chapter 247, was included in the EPP curriculum; (2) To what extent Texas public universities with approved EPP programs provided faculty opportunities for…

Basic science faculty in surgical departments: advantages, disadvantages and opportunities.

PubMed

Chinoy, Mala R; Moskowitz, Jay; Wilmore, Douglas W; Souba, Wiley W

2005-01-01

The number of Ph.D. faculty in clinical departments now exceeds the number of Ph.D. faculty in basic science departments. Given the escalating pressures on academic surgeons to produce in the clinical arena, the recruitment and retention of high-quality Ph.D.s will become critical to the success of an academic surgical department. This success will be as dependent on the surgical faculty understanding the importance of the partnership as the success of the Ph.D. investigator. Tighter alignment among the various clinical and research programs and between surgeons and basic scientists will facilitate the generation of new knowledge that can be translated into useful products and services (thus improving care). To capitalize on what Ph.D.s bring to the table, surgery departments may need to establish a more formal research infrastructure that encourages the ongoing exchange of ideas and resources. Physically removing barriers between the research groups, encouraging the open exchange of techniques and observations and sharing core laboratories is characteristic of successful research teams. These strategies can meaningfully contribute to developing successful training program grants, program projects and bringing greater research recognition to the department of surgery.

100 years of occupational safety research: From basic protections and work analysis to a multilevel view of workplace safety and risk.

PubMed

Hofmann, David A; Burke, Michael J; Zohar, Dov

2017-03-01

Starting with initiatives dating back to the mid-1800s, we provide a high-level review of the key trends and developments in the application of applied psychology to the field of occupational safety. Factory laws, basic worker compensation, and research on accident proneness comprised much of the early work. Thus, early research and practice very much focused on the individual worker, the design of their work, and their basic protection. Gradually and over time, the focus began to navigate further into the organizational context. One of the early efforts to broaden beyond the individual worker was a significant focus on safety-related training during the middle of the 20th century. Toward the latter years of the 20th century and continuing the move from the individual worker to the broader organizational context, there was a significant increase in leadership and organizational climate (safety climate) research. Ultimately, this resulted in the development of a multilevel model of safety culture/climate. After discussing these trends, we identify key conclusions and opportunities for future research. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

The Neurolab mission and biomedical engineering: a partnership for the future.

PubMed

Liskowsky, D R; Frey, M A; Sulzman, F M; White, R J; Likowsky, D R

1996-01-01

Over the last five years, with the advent of flights of U.S. Shuttle/Spacelab missions dedicated entirely to life sciences research, the opportunities for conducting serious studies that use a fully outfitted space laboratory to better understand basic biological processes have increased. The last of this series of Shuttle/Spacelab missions, currently scheduled for 1998, is dedicated entirely to neuroscience and behavioral research. The mission, named Neurolab, includes a broad range of experiments that build on previous research efforts, as well as studies related to less mature areas of space neuroscience. The Neurolab mission provides the global scientific community with the opportunity to use the space environment for investigations that exploit microgravity to increase our understanding of basic processes in neuroscience. The results from this premier mission should lead to a significant advancement in the field as a whole and to the opening of new lines of investigation for future research. Experiments under development for this mission will utilize human subjects as well as a variety of other species. The capacity to carry out detailed experiments on both human and animal subjects in space allows a diverse complement of studies that investigate functional changes and their underlying molecular, cellular, and physiological mechanisms. In order to conduct these experiments, a wide array of biomedical instrumentation will be used, including some instruments and devices being developed especially for the mission.

The Neurolab mission and biomedical engineering: a partnership for the future

NASA Technical Reports Server (NTRS)

Liskowsky, D. R.; Frey, M. A.; Sulzman, F. M.; White, R. J.; Likowsky, D. R.

1996-01-01

Over the last five years, with the advent of flights of U.S. Shuttle/Spacelab missions dedicated entirely to life sciences research, the opportunities for conducting serious studies that use a fully outfitted space laboratory to better understand basic biological processes have increased. The last of this series of Shuttle/Spacelab missions, currently scheduled for 1998, is dedicated entirely to neuroscience and behavioral research. The mission, named Neurolab, includes a broad range of experiments that build on previous research efforts, as well as studies related to less mature areas of space neuroscience. The Neurolab mission provides the global scientific community with the opportunity to use the space environment for investigations that exploit microgravity to increase our understanding of basic processes in neuroscience. The results from this premier mission should lead to a significant advancement in the field as a whole and to the opening of new lines of investigation for future research. Experiments under development for this mission will utilize human subjects as well as a variety of other species. The capacity to carry out detailed experiments on both human and animal subjects in space allows a diverse complement of studies that investigate functional changes and their underlying molecular, cellular, and physiological mechanisms. In order to conduct these experiments, a wide array of biomedical instrumentation will be used, including some instruments and devices being developed especially for the mission.

A model for integrating clinical care and basic science research, and pitfalls of performing complex research projects for addressing a clinical challenge.

PubMed

Steck, R; Epari, D R; Schuetz, M A

2010-07-01

The collaboration of clinicians with basic science researchers is crucial for addressing clinically relevant research questions. In order to initiate such mutually beneficial relationships, we propose a model where early career clinicians spend a designated time embedded in established basic science research groups, in order to pursue a postgraduate qualification. During this time, clinicians become integral members of the research team, fostering long term relationships and opening up opportunities for continuing collaboration. However, for these collaborations to be successful there are pitfalls to be avoided. Limited time and funding can lead to attempts to answer clinical challenges with highly complex research projects characterised by a large number of "clinical" factors being introduced in the hope that the research outcomes will be more clinically relevant. As a result, the complexity of such studies and variability of its outcomes may lead to difficulties in drawing scientifically justified and clinically useful conclusions. Consequently, we stress that it is the basic science researcher and the clinician's obligation to be mindful of the limitations and challenges of such multi-factorial research projects. A systematic step-by-step approach to address clinical research questions with limited, but highly targeted and well defined research projects provides the solid foundation which may lead to the development of a longer term research program for addressing more challenging clinical problems. Ultimately, we believe that it is such models, encouraging the vital collaboration between clinicians and researchers for the work on targeted, well defined research projects, which will result in answers to the important clinical challenges of today. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Translational physiology: from molecules to public health.

PubMed

Seals, Douglas R

2013-07-15

The term 'translational research' was coined 20 years ago and has become a guiding influence in biomedical research. It refers to a process by which the findings of basic research are extended to the clinical research setting (bench to bedside) and then to clinical practice and eventually health policy (bedside to community). It is a dynamic, multidisciplinary research approach. The concept of translational physiology applies the translational research model to the physiological sciences. It differs from the traditional areas of integrative and clinical physiology by its broad investigative scope of basic research to community health. Translational physiology offers exciting opportunities, but presently is under-developed and -utilized. A key challenge will be to expand physiological research by extending investigations to communities of patients and healthy (or at risk) individuals. This will allow bidirectional physiological investigation throughout the translational continuum: basic research observations can be studied up to the population level, and mechanisms can be assessed by 'reverse translation' in clinical research settings and preclinical models based on initial observations made in populations. Examples of translational physiology questions, experimental approaches, roadblocks and strategies for promotion are discussed. Translational physiology provides a novel framework for physiology programs and an investigational platform for physiologists to study function from molecular events to public health. It holds promise for enhancing the completeness and societal impact of our work, while further solidifying the critical role of physiology in the biomedical research enterprise.

A Lifetime of Learning

ERIC Educational Resources Information Center

Office of Education (DHEW), Washington, DC.

This booklet discusses three Federal programs for the continuing education of adults: Adult Basic Education; Community Service and Continuing Education; and Civil Defense Education. Initiated through the Economic Opportunity Act of 1964, Adult Basic Education began operation in 1965, financed by the Office of Economic Opportunity and administered…

Translational physiology: from molecules to public health

PubMed Central

Seals, Douglas R

2013-01-01

The term ‘translational research’ was coined 20 years ago and has become a guiding influence in biomedical research. It refers to a process by which the findings of basic research are extended to the clinical research setting (bench to bedside) and then to clinical practice and eventually health policy (bedside to community). It is a dynamic, multidisciplinary research approach. The concept of translational physiology applies the translational research model to the physiological sciences. It differs from the traditional areas of integrative and clinical physiology by its broad investigative scope of basic research to community health. Translational physiology offers exciting opportunities, but presently is under-developed and -utilized. A key challenge will be to expand physiological research by extending investigations to communities of patients and healthy (or at risk) individuals. This will allow bidirectional physiological investigation throughout the translational continuum: basic research observations can be studied up to the population level, and mechanisms can be assessed by ‘reverse translation’ in clinical research settings and preclinical models based on initial observations made in populations. Examples of translational physiology questions, experimental approaches, roadblocks and strategies for promotion are discussed. Translational physiology provides a novel framework for physiology programs and an investigational platform for physiologists to study function from molecular events to public health. It holds promise for enhancing the completeness and societal impact of our work, while further solidifying the critical role of physiology in the biomedical research enterprise. PMID:23732641

Report of the Office of Science and Technology Policy Working Group on Basic Research in the Department of Energy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1978-06-01

The OSTP Working Group was commissioned to advise on the scope and quality of basic research conducted by and on behalf of DOE. The Group formed Subgroups in these areas: large-scale solar, fossil, fusion, small technology, and geothermal, environment and life sciences, social sciences, transportation, and fission. Work of the Subgroups forms the basis of much of this report, which has five sections. Following the introduction, preface, and executive summary (Section II), there is discussion of broad problem areas as they pertain to research (Section III). Section IV consists of general recommendations regarding policies for, as well as management andmore » scope of, research within the DOE: this section has four parts: Part A pertains to research in programmatic areas under the aegis of the Assistant Secretaries; Part B deals with the role and structure of the Office of Energy Research; Part C is concerned with broad research issues; and Part D addresses DOE Laboratories and Energy Research Centers. In Section V, research needs and opportunities for selected programs are discussed.« less

Translational Epidemiology in Psychiatry

PubMed Central

Weissman, Myrna M.; Brown, Alan S.; Talati, Ardesheer

2012-01-01

Translational research generally refers to the application of knowledge generated by advances in basic sciences research translated into new approaches for diagnosis, prevention, and treatment of disease. This direction is called bench-to-bedside. Psychiatry has similarly emphasized the basic sciences as the starting point of translational research. This article introduces the term translational epidemiology for psychiatry research as a bidirectional concept in which the knowledge generated from the bedside or the population can also be translated to the benches of laboratory science. Epidemiologic studies are primarily observational but can generate representative samples, novel designs, and hypotheses that can be translated into more tractable experimental approaches in the clinical and basic sciences. This bedside-to-bench concept has not been explicated in psychiatry, although there are an increasing number of examples in the research literature. This article describes selected epidemiologic designs, providing examples and opportunities for translational research from community surveys and prospective, birth cohort, and family-based designs. Rapid developments in informatics, emphases on large sample collection for genetic and biomarker studies, and interest in personalized medicine—which requires information on relative and absolute risk factors—make this topic timely. The approach described has implications for providing fresh metaphors to communicate complex issues in interdisciplinary collaborations and for training in epidemiology and other sciences in psychiatry. PMID:21646577

Natural History Dioramas: An Opportunity for Children to Observe Science in Action in a Moment of Time

ERIC Educational Resources Information Center

Gkouskou, Eirini; Tunnicliffe, Sue Dale

2017-01-01

?he nature of scientific research goes beyond the learning of concepts and basic manipulation to the key factors of engaging students in identifying relevant evidence and reflecting on its interpretation. It is argued that young children have the ability to acquire viable, realistic concepts of the living world when involved in relevant activities…

Big Data in the Campus Landscape: Basic Infrastructure Support. ECAR Working Group Paper

ERIC Educational Resources Information Center

Almes, Guy T.; Zottola, Ralph J.

2014-01-01

This paper is part of series of the EDUCAUSE Center for Analysis and Research Campus Cyberinfrastructure (ECAR-CCI) Working Group. The topic of big data continues to receive a great deal of publicity because of its promise for opening new avenues of scholarly discovery and commercial opportunity. The ability to sift rapidly through massive amounts…

Accelerating the pace of discovery in orthopaedic research: A vision toward team science.

PubMed

Bahney, Chelsea S; Bruder, Scott P; Cain, Jarrett D; Keyak, Joyce H; Killian, Megan L; Shapiro, Irving M; Jones, Lynne C

2016-10-01

The landscape of basic science in the United States and around the world is changing, and the field of orthopaedic research is positioned to lead by embracing a culture of collaborative, team science that reflects our field's interdisciplinary nature. In this article we hope to address some of the cultural challenges and programmatic barriers that impede a team science approach in the US and suggest opportunities for change. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1673-1679, 2016. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

Photovoltaic Research in the Small Business Innovative Research Program

NASA Astrophysics Data System (ADS)

Bower, Ward I.; Bulawka, Alec

1997-02-01

The Small Business Innovative Research Program (SBIR) is currently authorized to be funded through September 30, 2000. The National Photovoltaics Program is a contributor to the Department of Energy (DOE) SBIR program. The small business photovoltaic industry has been benefiting from the SBIR program through awards that have funded basic research, new processes and products that have PV and other commercial applications. This paper provides information on SBIR opportunities, selected details of the SBIR program, statistics from the 1995 and 1996 DOE SBIR program, and methods for improving PV industry participation and success in the SBIR program.

Future directions in research on sexual minority adolescent mental, behavioral, and sexual health

PubMed Central

Mustanski, Brian

2015-01-01

This article describes current knowledge on sexual, mental, and behavioral health of sexual minority (SM) youth and identifies gaps that would benefit from future research. A translational sciences framework is used to conceptualize the article, discussing findings and gaps along the spectrum from basic research on prevalence and mechanisms, to intervention development and testing, to implementation. Relative to adults, there has been much less research on adolescents and very few studies that had longitudinal follow-up beyond one year. Due to historical changes in the social acceptance of the SM community, new cohorts are needed to represent contemporary life experiences and associated health consequences. Important theoretical developments have occurred in conceptualizing mechanisms that drive SM health disparities and mechanistic research is underway, including studies that identify individual and structural risk/protective factors. Research opportunities exist in the utilization of sibling-comparison designs, inclusion of parents, and studying romantic relationships. Methodological innovation is needed in sampling SM populations. There has been less intervention research and approaches should consider natural resiliencies, life-course frameworks, prevention science, multiple levels of influence, and the importance of implementation. Regulatory obstacles are created when ethics boards elect to require parental permission and ethics research is needed. There has been inconsistent inclusion of SM populations in the definition of “health disparity population,” which impacts funding and training opportunities. There are incredible opportunities for scholars to make substantial and foundational contributions to help address the health of SM youth, and new funding opportunities to do so. PMID:25575125

Anatomy teaching assistants: facilitating teaching skills for medical students through apprenticeship and mentoring.

PubMed

Lachman, Nirusha; Christensen, Kevin N; Pawlina, Wojciech

2013-01-01

Significant increase in the literature regarding "residents as teachers" highlights the importance of providing opportunities and implementing guidelines for continuing medical education and professional growth. While most medical students are enthusiastic about their future role as resident-educators, both students and residents feel uncomfortable teaching their peers due to the lack of necessary skills. However, whilst limited and perhaps only available to select individuals, opportunities for developing good teaching practice do exist and may be identified in courses that offer basic sciences. The Department of Anatomy, College of Medicine, Mayo Clinic offers a teaching assistant (TA) elective experience to third- and fourth-year medical students through integrated apprenticeship and mentoring during the human structure didactic block. This article, aims to describe a curriculum for a TA elective within the framework of a basic science course through mentoring and apprenticeship. Opportunities for medical students to become TAs, process of TAs' recruitment, mentoring and facilitation of teaching and education research skills, a method for providing feedback and debriefing are described. Developing teaching practice based on apprenticeship and mentoring lends to more accountability to both TA's and course faculty by incorporating universal competencies to facilitate the TA experience.

Opportunities for Epidemiologists in Implementation Science: A Primer.

PubMed

Neta, Gila; Brownson, Ross C; Chambers, David A

2018-05-01

The field of epidemiology has been defined as the study of the spread and control of disease. However, epidemiology frequently focuses on studies of etiology and distribution of disease at the cost of understanding the best ways to control disease. Moreover, only a small fraction of scientific discoveries are translated into public health practice, and the process from discovery to translation is exceedingly slow. Given the importance of translational science, the future of epidemiologic training should include competency in implementation science, whose goal is to rapidly move evidence into practice. Our purpose in this paper is to provide epidemiologists with a primer in implementation science, which includes dissemination research and implementation research as defined by the National Institutes of Health. We describe the basic principles of implementation science, highlight key components for conducting research, provide examples of implementation studies that encompass epidemiology, and offer resources and opportunities for continued learning. There is a clear need for greater speed, relevance, and application of evidence into practice, programs, and policies and an opportunity to enable epidemiologists to conduct research that not only will inform practitioners and policy-makers of risk but also will enhance the likelihood that evidence will be implemented.

Characterizing job satisfaction and intent to leave among nationally registered emergency medical technicians: an analysis of the 2005 LEADS survey.

PubMed

Patterson, P Daniel; Moore, Charity G; Sanddal, Nels D; Wingrove, Gary; LaCroix, Brian

2009-01-01

The primary purpose of this study was to characterize job satisfaction with opportunities for advancement, job satisfaction with pay and benefits, and intent to leave the EMS profession among Nationally Registered EMT-Basics and EMT-Paramedics. A secondary data analysis was performed on the National Registry of EMTs Longitudinal Emergency Medical Technician Attributes and Demographic Study Project (LEADS) 2005 core survey. We used chi-square and multiple logistic regression analyses to test for differences in job satisfaction with opportunities for advancement, job satisfaction with pay and benefits, and intent to leave the EMS profession across years of experience and work location. Among 11 measures of job satisfaction, NREMT-Basics and NREMT-Paramedics were least satisfied with opportunities for advancement and pay and benefits (67.8 and 55.2%, respectively). Nearly 6% of respondents reported intentions of leaving the profession within 12 months. In univariate analyses, job satisfaction with advancement opportunities varied across years of experience and work location. Job satisfaction with pay and benefits varied across years of experience and work location. The proportion reporting intentions of leaving the profession did not vary across the two independent variables of interest. In multivariable logistic regression, statistical differences observed in univariate analyses were attenuated to non-significance across all outcome models. Income, personal health, level of EMS certification, and type of EMS work were significant in several outcome models. EMS workforce research is at its infancy, thus our study adds to a limited but growing body of knowledge. In future and replicated research, one will need to consider different person and organizational variables in predicting different measures of job satisfaction among EMS personnel.

The Transition of Acute Postoperative Pain to Chronic Pain: An Integrative Overview of Research on Mechanisms.

PubMed

Chapman, C Richard; Vierck, Charles J

2017-04-01

The nature of the transition from acute to chronic pain still eludes explanation, but chronic pain resulting from surgery provides a natural experiment that invites clinical epidemiological investigation and basic scientific inquiry into the mechanisms of this transition. The primary purpose of this article is to review current knowledge and hypotheses on the transition from acute to persistent postsurgical pain, summarizing literature on clinical epidemiological studies of persistent postsurgical pain development, as well as basic neurophysiological studies targeting mechanisms in the periphery, spinal cord, and brain. The second purpose of this article is to integrate theory, information, and causal reasoning in these areas. Conceptual mapping reveals 5 classes of hypotheses pertaining to pain. These propose that chronic pain results from: 1) persistent noxious signaling in the periphery; 2) enduring maladaptive neuroplastic changes at the spinal dorsal horn and/or higher central nervous system structures reflecting a multiplicity of factors, including peripherally released neurotrophic factors and interactions between neurons and microglia; 3) compromised inhibitory modulation of noxious signaling in medullary-spinal pathways; 4) descending facilitatory modulation; and 5) maladaptive brain remodeling in function, structure, and connectivity. The third purpose of this article is to identify barriers to progress and review opportunities for advancing the field. This review reveals a need for a concerted, strategic effort toward integrating clinical epidemiology, basic science research, and current theory about pain mechanisms to hasten progress toward understanding, managing, and preventing persistent postsurgical pain. The development of chronic pain after surgery is a major clinical problem that provides an opportunity to study the transition from acute to chronic pain at epidemiologic and basic science levels. Strategic, coordinated, multidisciplinary research efforts targeting mechanisms of pain chronification can to help minimize or eliminate persistent postsurgical pain. Copyright © 2016 American Pain Society. Published by Elsevier Inc. All rights reserved.

Young Investigator Research Program (YIP)

NASA Astrophysics Data System (ADS)

Robinson, Ellen

The Air Force YIP supports scientists and engineers who have received Ph.D. or equivalent degrees in the last five years and show exceptional ability and promise for conducting basic research. The objective of this program is to foster creative basic research in science and engineering; enhance early career development of outstanding young investigators; and increase opportunities for the young investigator to recognize the Air Force mission and related challenges in science and engineering. Individual awards will be made to U.S. institutions of higher education, industrial laboratories or non-profit research organizations where the principal investigator is a U.S. citizen, national or permanent resident; employed on a full-time basis and hold a regular position. Researchers working at the Federally Funded Research and Development Centers and DoD Laboratories will not be considered for the YIP competition. Each award will be funded at the 120K level for three years. Exceptional proposals will be considered individually for higher funding levels and longer duration. http://www.wpafb.af.mil/Welcome/Fact-Sheets/Display/Article/842100#anchor2 I will brief Air Force Office Of Scientific Research Young Investigator Research Program.

Determinants of corporate dividend policy in Indonesia

NASA Astrophysics Data System (ADS)

Lestari, H. S.

2018-01-01

This study aims to investigate the determinants factors that effect the dividend policy. The sample used in this research is manufacture companies listed in Indonesia Stock Exchange (IDX) and the period 2011 - 2015. There are independent variables such as earning, cash flow, free cash flow, debt, growth opportunities, investment opportunities, firm size, largest shareholder, firm risk, lagged dividend and dividend policy used as dependent variable. The study examines a total of 32 manufacture companies. After analyzing the data using the program software Eviews 9.0 by multiples regression analysis reveal that earning, cash flow, free cash flow, firm size, and lagged dividend have significant effect on dividend policy, whereas debt, growth opportunities, investment opportunities, largest shareholder, and firm risk have no significant effect on dividend policy. The results of this study are expected to be implemented by the financial managers in improving corporate profits and basic information as return on investment decisions.

[Incentives and disincentives for research and development of new drugs by the pharmaceutical industry].

PubMed

Curcio, Pasqualina Curcio

2008-10-01

The authors present a model with factors that influence research and development decisions by the pharmaceutical industry: risk of disease transmission and possibility of control; case-fatality and the presence of cure or treatments; income; number of persons who demand the medicine; and opportunity costs for the company. Companies tend to invest in markets with inelastic demand (highly contagious diseases with no possibility of controlling transmission and/or very lethal diseases without treatment) and/or where there is a large population or high per capita income. Companies tend not to invest in markets where marginal costs exceed marginal income, particularly when costs increase permanently as a consequence of rising opportunity costs generated by foregoing profit in other markets. In such cases, policies to subsidize R&D are not effective, and policies must be orientated towards strengthening basic and applied research by public institutions.

Synergistic use of adult and embryonic stem cells to study human hematopoiesis.

PubMed

Martin, Colin H; Kaufman, Dan S

2005-10-01

Embryonic stem cells (ESCs) and adult stem cells both provide important resources to define the mechanisms of hematopoietic cell development. To date, studies that utilize hematopoietic stem cells (HSCs) isolated from sites such as bone marrow or umbilical cord blood have been the primary means to identify molecular and phenotypic characteristics of blood cell populations able to mediate long-term hematopoietic engraftment. Although these HSCs are very useful clinically, they are difficult to expand in culture. Now, basic research on human ESCs provides opportunities for novel investigations into the mechanisms of HSC self-renewal. Eventually, the long history of basic and clinical research with adult hematopoietic cell transplantation could translate to establish human ESCs as a suitable alternative starting cell source for clinical hematopoietic reconstitution.

Science Educational Outreach Programs That Benefit Students and Scientists

PubMed Central

Enyeart, Peter; Gracia, Brant; Wessel, Aimee; Jarmoskaite, Inga; Polioudakis, Damon; Stuart, Yoel; Gonzalez, Tony; MacKrell, Al; Rodenbusch, Stacia; Stovall, Gwendolyn M.; Beckham, Josh T.; Montgomery, Michael; Tasneem, Tania; Jones, Jack; Simmons, Sarah; Roux, Stanley

2016-01-01

Both scientists and the public would benefit from improved communication of basic scientific research and from integrating scientists into education outreach, but opportunities to support these efforts are limited. We have developed two low-cost programs—"Present Your PhD Thesis to a 12-Year-Old" and "Shadow a Scientist”—that combine training in science communication with outreach to area middle schools. We assessed the outcomes of these programs and found a 2-fold benefit: scientists improve their communication skills by explaining basic science research to a general audience, and students' enthusiasm for science and their scientific knowledge are increased. Here we present details about both programs, along with our assessment of them, and discuss the feasibility of exporting these programs to other universities. PMID:26844991

Propulsion System Airframe Integration Issues and Aerodynamic Database Development for the Hyper-X Flight Research Vehicle

NASA Technical Reports Server (NTRS)

Engelund, Walter C.; Holland, Scott D.; Cockrell, Charles E., Jr.; Bittner, Robert D.

1999-01-01

NASA's Hyper-X Research Vehicle will provide a unique opportunity to obtain data on an operational airframe integrated scramjet propulsion system at true flight conditions. The airframe integrated nature of the scramjet engine with the Hyper-X vehicle results in a strong coupling effect between the propulsion system operation and the airframe s basic aerodynamic characteristics. Comments on general airframe integrated scramjet propulsion system effects on vehicle aerodynamic performance, stability, and control are provided, followed by examples specific to the Hyper-X research vehicle. An overview is provided of the current activities associated with the development of the Hyper-X aerodynamic database, including wind tunnel test activities and parallel CFD analysis efforts. A brief summary of the Hyper-X aerodynamic characteristics is provided, including the direct and indirect effects of the airframe integrated scramjet propulsion system operation on the basic airframe stability and control characteristics.

Open Science: a first step towards Science Communication

NASA Astrophysics Data System (ADS)

Grigorov, Ivo; Tuddenham, Peter

2015-04-01

As Earth Science communicators gear up to adopt the new tools and captivating approaches to engage citizen scientists, budding entrepreneurs, policy makers and the public in general, researchers have the responsibility, and opportunity, to fully adopt Open Science principles and capitalize on its full societal impact and engagement. Open Science is about removing all barriers to basic research, whatever its formats, so that it can be freely used, re-used and re-hashed, thus fueling discourse and accelerating generation of innovative ideas. The concept is central to EU's Responsible Research and Innovation philosophy, and removing barriers to basic research measurably contributes to engaging citizen scientists into the research process, it sets the scene for co-creation of solutions to societal challenges, and raises the general science literacy level of the public. Despite this potential, only 50% of today's basic research is freely available. Open Science can be the first passive step of communicating marine research outside academia. Full and unrestricted access to our knowledge including data, software code and scientific publications is not just an ethical obligation, but also gives solid credibility to a more sophisticated communication strategy on engaging society. The presentation will demonstrate how Open Science perfectly compliments a coherent communication strategy for placing Marine Research in societal context, and how it underpin an effective integration of Ocean & Earth Literacy principles in standard educational, as well mobilizing citizen marine scientists, thus making marine science Open Science.

Herbert Woodson: encouraging exploration in research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Whitaker, R.; Woodson, H.

A profile of Herbert Woodson, an electrical engineering professor, describes his loyalty to fundamental research while consulting and committee activities keep him in touch with the practical end of electricity. He stresses the need to find innovative ways to use electricity that will keep the US competitive. This means focusing at the consumption rather than the production side. As a working member of the Electric Power Research Institute's Advisory Council, he cites learning opportunities from other members and satisfaction with the advisory apparatus. Fundamental research requires adequate funding to pursue an identified problem. Successful industries earmark 5% or more formore » basic research.« less

[The Academy of Ideas - second edition 2014].

PubMed

2014-01-01

The Academy of Ideas is an initiative of the Italian Society of Nephrology, dedicated to young people who work in nephrology. The 2014 edition wants to foster innovative ideas at different levels of maturity along the research and innovation process, through two distinct sections meant for people who present basic or applied research ideas and for people who submit proofs of concepts transferable to products or services in a relatively short time period. The proposal aims to enhance grant application skills, giving to young researchers the opportunity of collaborating with multi-disciplinary groups of professionals; help young researchers to exploit ideas arising from clinical research and showing a Technology Readiness Level that allows immediate or close in time applicability; foster the understanding of the business perspective in the nephrology sector: giving to young scientists the opportunity to have in-hand experience on challenges related to bringing to the market research results; create a network of knowledge and collaboration among young researchers to facilitate the establishment of collaborative relationships and promote the creation of new projects and publications of high scientific impact.

Thin film bioreactors in space

NASA Technical Reports Server (NTRS)

Hughes-Fulford, M.; Scheld, H. W.

1989-01-01

Studies from the Skylab, SL-3 and D-1 missions have demonstrated that biological organisms grown in microgravity have changes in basic cellular functions such as DNA, mRNA and protein synthesis, cytoskeleton synthesis, glucose utilization, and cellular differentiation. Since microgravity could affect prokaryotic and eukaryotic cells at a subcellular and molecular level, space offers an opportunity to learn more about basic biological systems with one inmportant variable removed. The thin film bioreactor will facilitate the handling of fluids in microgravity, under constant temperature and will allow multiple samples of cells to be grown with variable conditions. Studies on cell cultures grown in microgravity would make it possible to identify and quantify changes in basic biological function in microgravity which are needed to develop new applications of orbital research and future biotechnology.

Unique aspects of Colorado State University`s REU Program in Radar and Remote Sensing

NASA Astrophysics Data System (ADS)

Hefner, E.; Chandrasekar, V.

2005-12-01

The primary mission for CSU`s REU program on radars is to create a real-life research experience for the undergraduates participating during the summer. The students are provided with a basic description of their unique research project and paired with a graduate mentor and/or faculty member. Even though the students are paired with a graduate mentor that has extensive knowledge of the assigned topic, the students are responsible for developing the project through their own efforts. Each student is also required to obtain a fundamental grasp of radar basics through independent study and a series of small lectures put on by researchers at CSU. As part of the real-life research each student is exposed to, every student has to develop and hone his or her presentation and writing skills with weekly presentations and mandatory proposal and report submittals. The program is structured such that each student has access to a vast resource of technical knowledge in the form of published documents and other researchers. This allows students that learn through different mediums to have all the necessary resources available to them. While the students are performing research in areas that have not been explored before, they are also given the opportunity to explore the differences between undergraduate and graduate school. Each student is given the ability to participate in GRE prep courses. Students are given the opportunity to assess their educations, and if they find through their research that they enjoy a specific topic or are lacking necessary background information, then they can choose to register for specific courses in the upcoming fall semester. Along with influencing course selection among the REU students, the students bring their experiences and newly developed research skills back to school with them.

Effective Classroom Management. The Basic Element of Effective Teaching. A Module for Undergraduate Instruction in Teacher Education in the RAFT Program at Mississippi State University.

ERIC Educational Resources Information Center

Handley, Herbert M., Ed.

This module, developed by the Research Applications for Teaching (RAFT) project, introduces the undergraduate student to practices of teachers in effective schools which facilitate the climate for learning in the classroom. Used with Canter's materials on assertive discipline, the preservice teachers should have an opportunity to reflect carefully…

Engaging local industry in the development of basic research infrastructure and instrumentation – The case of HIE-ISOLDE and ESS Scandinavia

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fahlander, Claes, E-mail: claes.fahlander@nuclear.lu.se

Two world-class research facilities, the European Spallation Source, ESS, and the light-source facility MAX-IV, are being built in southern Sweden. They will primarily, when completed, be used for research in the fields of material sciences, life sciences, medicine and pharmacology. Their construction and the operation and maintenance of them for many years will create new business opportunities for companies in Europe in general and in Sweden, Denmark and Norway in particular in many different sectors. A project, CATE, Cluster for Accelerator Technology, was set up with the aim to strengthen the skills of companies in the Öresund-Kattegat-Skagerrak region in Scandinaviamore » in the field of accelerator technology such that they will become competitive and be able to take advantage of the potential of these two research facilities. CATE was strategically important and has helped to create partnerships between companies and new business opportunities in the region.« less

Engaging local industry in the development of basic research infrastructure and instrumentation - The case of HIE-ISOLDE and ESS Scandinavia

NASA Astrophysics Data System (ADS)

Fahlander, Claes

2016-07-01

Two world-class research facilities, the European Spallation Source, ESS, and the light-source facility MAX-IV, are being built in southern Sweden. They will primarily, when completed, be used for research in the fields of material sciences, life sciences, medicine and pharmacology. Their construction and the operation and maintenance of them for many years will create new business opportunities for companies in Europe in general and in Sweden, Denmark and Norway in particular in many different sectors. A project, CATE, Cluster for Accelerator Technology, was set up with the aim to strengthen the skills of companies in the Öresund-Kattegat-Skagerrak region in Scandinavia in the field of accelerator technology such that they will become competitive and be able to take advantage of the potential of these two research facilities. CATE was strategically important and has helped to create partnerships between companies and new business opportunities in the region.

Data Crosscutting Requirements Review

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kleese van Dam, Kerstin; Shoshani, Arie; Plata, Charity

2013-04-01

In April 2013, a diverse group of researchers from the U.S. Department of Energy (DOE) scientific community assembled to assess data requirements associated with DOE-sponsored scientific facilities and large-scale experiments. Participants in the review included facilities staff, program managers, and scientific experts from the offices of Basic Energy Sciences, Biological and Environmental Research, High Energy Physics, and Advanced Scientific Computing Research. As part of the meeting, review participants discussed key issues associated with three distinct aspects of the data challenge: 1) processing, 2) management, and 3) analysis. These discussions identified commonalities and differences among the needs of varied scientific communities.more » They also helped to articulate gaps between current approaches and future needs, as well as the research advances that will be required to close these gaps. Moreover, the review provided a rare opportunity for experts from across the Office of Science to learn about their collective expertise, challenges, and opportunities. The "Data Crosscutting Requirements Review" generated specific findings and recommendations for addressing large-scale data crosscutting requirements.« less

A case study in innovative outreach--combining training, research, and technology transfer to address real-world problems.

PubMed Central

Chang, D P

1998-01-01

Outreach, training, technology transfer, and research are often treated as programmatically distinct activities. The interdisciplinary and applied aspects of the Superfund Basic Research Program offer an opportunity to explore different models. A case study is presented that describes a collaborative outreach effort that combines all of the above. It involves the University of California's Davis and Berkeley program projects, the University of California Systemwide Toxic Substances Research and Teaching Program, the U.S. Navy's civilian workforce at the former Mare Island Naval Shipyard, Vallejo, California (MINSY), a Department of Defense (DoD) Environmental Education Demonstration Grant program, and the Private Industry Council of Napa and Sonoma counties in California. The effort applied a Superfund-developed technology to a combined waste, radium and polychlorinated biphenyl contamination, stemming from a problematic removal action at an installation/restoration site at MINSY. The effort demonstrates that opportunities for similar collaborations are possible at DoD installations. PMID:9703494

Evolutionary ethnobiology and cultural evolution: opportunities for research and dialog.

PubMed

Santoro, Flávia Rosa; Nascimento, André Luiz Borba; Soldati, Gustavo Taboada; Ferreira Júnior, Washington Soares; Albuquerque, Ulysses Paulino

2018-01-09

The interest in theoretical frameworks that improve our understanding of social-ecological systems is growing within the field of ethnobiology. Several evolutionary questions may underlie the relationships between people and the natural resources that are investigated in this field. A new branch of research, known as evolutionary ethnobiology (EE), focuses on these questions and has recently been formally conceptualized. The field of cultural evolution (CE) has significantly contributed to the development of this new field, and it has introduced the Darwinian concepts of variation, competition, and heredity to studies that focus on the dynamics of local knowledge. In this article, we introduce CE as an important theoretical framework for evolutionary ethnobiological research. We present the basic concepts and assumptions of CE, along with the adjustments that are necessary for its application in EE. We discuss different ethnobiological studies in the context of this new framework and the new opportunities for research that exist in this area. We also propose a dialog that includes our findings in the context of cultural evolution.

Optical Coherence Tomography: Basic Concepts and Applications in Neuroscience Research

PubMed Central

2017-01-01

Optical coherence tomography is a micrometer-scale imaging modality that permits label-free, cross-sectional imaging of biological tissue microstructure using tissue backscattering properties. After its invention in the 1990s, OCT is now being widely used in several branches of neuroscience as well as other fields of biomedical science. This review study reports an overview of OCT's applications in several branches or subbranches of neuroscience such as neuroimaging, neurology, neurosurgery, neuropathology, and neuroembryology. This study has briefly summarized the recent applications of OCT in neuroscience research, including a comparison, and provides a discussion of the remaining challenges and opportunities in addition to future directions. The chief aim of the review study is to draw the attention of a broad neuroscience community in order to maximize the applications of OCT in other branches of neuroscience too, and the study may also serve as a benchmark for future OCT-based neuroscience research. Despite some limitations, OCT proves to be a useful imaging tool in both basic and clinical neuroscience research. PMID:29214158

Memory Reconsolidation Interference as an Emerging Treatment for Emotional Disorders: Strengths, Limitations, Challenges and Opportunities

PubMed Central

Beckers, Tom; Kindt, Merel

2016-01-01

Experimental research on emotional memory reconsolidation interference, or the induction of amnesia for previously established emotional memory, has a long tradition, but the potential of that research for the development of novel interventions to treat psychological disorders has been recognized only recently. Here we provide an overview of basic research and clinical studies on emotional memory reconsolidation interference. We point out specific advantages of interventions based on memory reconsolidation interference over traditional treatment for emotional disorders. We also explain how findings from basic research suggest limitations and challenges to clinical translation that may help to understand why clinical trials have met with mixed success so far and how their success can be increased. In closing, we preview new intervention approaches beyond the induction of amnesia that the phenomenon of memory reconsolidation may afford for alleviating the burden imposed by emotional memories and comment on theoretical controversies regarding the nature of memory reconsolidation. PMID:28375725

Division of Energy Biosciences annual report and summaries of FY 1996 activities

DOE Office of Scientific and Technical Information (OSTI.GOV)

NONE

1997-04-01

The mission of the Division of Energy Biosciences is to support research that advances the fundamental knowledge necessary for the future development of biotechnologies related to the Department of Energy`s mission. The departmental civilian objectives include effective and efficient energy production, energy conservation, environmental restoration, and waste management. The Energy Biosciences program emphasizes research in the microbiological and plant sciences, as these understudied areas offer numerous scientific opportunities to dramatically influence environmentally sensible energy production and conservation. The research supported is focused on the basic mechanism affecting plant productivity, conversion of biomass and other organic materials into fuels and chemicalsmore » by microbial systems, and the ability of biological systems to replace energy-intensive or pollutant-producing processes. The Division also addresses the increasing number of new opportunities arising at the interface of biology with other basic energy-related sciences such as biosynthesis of novel materials and the influence of soil organisms on geological processes. This report gives summaries on 225 projects on photosynthesis, membrane or ion transport, plant metabolism and biosynthesis, carbohydrate metabolism lipid metabolism, plant growth and development, plant genetic regulation and genetic mechanisms, plant cell wall development, lignin-polysaccharide breakdown, nitrogen fixation and plant-microbial symbiosis, mechanism for plant adaptation, fermentative microbial metabolism, one and two carbon microbial metabolism, extremophilic microbes, microbial respiration, nutrition and metal metabolism, and materials biosynthesis.« less

The National Institute of Environmental Health Sciences Superfund Research Program: a model for multidisciplinary training of the next generation of environmental health scientists.

PubMed

Carlin, Danielle J; Henry, Heather; Heacock, Michelle; Trottier, Brittany; Drew, Christina H; Suk, William A

2018-03-28

The National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program (SRP) funds university-based, multidisciplinary research on human health and environmental science and engineering with the central goals to understand how hazardous substances contribute to disease and how to prevent exposures to these environmental chemicals. This multi-disciplinary approach allows early career scientists (e.g. graduate students and postdoctoral researchers) to gain experience in problem-based, solution-oriented research and to conduct research in a highly collaborative environment. Training the next generation of environmental health scientists has been an important part of the SRP since its inception. In addition to basic research, the SRP has grown to include support of broader training experiences such as those in research translation and community engagement activities that provide opportunities to give new scientists many of the skills they will need to be successful in their field of research. Looking to the future, the SRP will continue to evolve its training component by tracking and analyzing outcomes from its trainees by using tools such as the NIEHS CareerTrac database system, by increasing opportunities for trainees interested in research that goes beyond US boundaries, and in the areas of bioinformatics and data integration. These opportunities will give them the skills needed to be competitive and successful no matter which employment sector they choose to enter after they have completed their training experience.

Basic research needs and opportunities on interfaces in solar materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Czanderna, A. W.; Gottschall, R. J.

1981-04-01

The workshop on research needs and recommended research programs on interfaces in solar energy conversion devices was held June 30-July 3, 1980. The papers deal mainly with solid-solid, solid-liquid, and solid-gas interfaces, sometimes involving multilayer solid-solid interfaces. They deal mainly with instrumental techniques of studying these interfaces so they can be optimized, so they can be fabricated with quality control and so changes with time can be forecast. The latter is required because a long lifetime (20 yrs is suggested) is necessary for economic reasons. Fifteen papers have been entered individually into EDB and ERA. (LTN)

Biophysics at the Boundaries: The Next Problem Sets

NASA Astrophysics Data System (ADS)

Skolnick, Malcolm

2009-03-01

The interface between physics and biology is one of the fastest growing subfields of physics. As knowledge of such topics as cellular processes and complex ecological systems advances, researchers have found that progress in understanding these and other systems requires application of more quantitative approaches. Today, there is a growing demand for quantitative and computational skills in biological research and the commercialization of that research. The fragmented teaching of science in our universities still leaves biology outside the quantitative and mathematical culture that is the foundation of physics. This is particularly inopportune at a time when the needs for quantitative thinking about biological systems are exploding. More physicists should be encouraged to become active in research and development in the growing application fields of biophysics including molecular genetics, biomedical imaging, tissue generation and regeneration, drug development, prosthetics, neural and brain function, kinetics of nonequilibrium open biological systems, metabolic networks, biological transport processes, large-scale biochemical networks and stochastic processes in biochemical systems to name a few. In addition to moving into basic research in these areas, there is increasing opportunity for physicists in industry beginning with entrepreneurial roles in taking research results out of the laboratory and in the industries who perfect and market the inventions and developments that physicists produce. In this talk we will identify and discuss emerging opportunities for physicists in biophysical and biotechnological pursuits ranging from basic research through development of applications and commercialization of results. This will include discussion of the roles of physicists in non-traditional areas apart from academia such as patent law, financial analysis and regulatory science and the problem sets assigned in education and training that will enable future biophysicists to fill these roles.

The value of biomedical research training for veterinary anatomic and clinical pathologists.

PubMed

Sharkey, L C; Simpson, R M; Wellman, M L; Craig, L E; Birkebak, T A; Kock, N D; Miller, M A; Harris, R K; Munson, L

2012-07-01

Veterinary pathologists traditionally have been actively engaged in research as principal investigators and as collaborators. Pathologists frequently obtain advanced training in research; however, it appears that in the last 10 years there has been a reversal of a previous trend toward increasing numbers of pathologists obtaining PhD degrees. This has arisen despite an established shortage of veterinarians engaged in research. This article evaluates the benefits of research training for individual pathologists, including a wide spectrum of professional opportunities and additional skill development beyond that usually provided by diagnostic pathology training alone. Various training models are discussed, including combined and sequential diagnostic residency and research degree training as well as the nondegree research fellowship programs more commonly pursued in human medicine. Best-practice recommendations for program infrastructure, mentorship, time management, and a team approach to research and research training are advocated to facilitate the development of successful programs and to encourage a continued emphasis on integrated training for pathologists as both clinical diagnosticians and experimentalists. This article is intended to help prospective and active pathology trainees, their mentors, and educational administrators optimize opportunities to ensure the future vitality of veterinary pathologists, and their contributions, in basic and applied research.

Global justice, capabilities approach and commercial surrogacy in India.

PubMed

Saravanan, Sheela

2015-08-01

Inequalities, ineffective governance, unclear surrogacy regulations and unethical practices make India an ideal environment for global injustice in the process of commercial surrogacy. This article aims to apply the 'capabilities approach' to find possibilities of global justice through human fellowship in the context of commercial surrogacy. I draw primarily on my research findings supplemented by other relevant empirical research and documentary films on surrogacy. The paper reveals inequalities and inadequate basic entitlements among surrogate mothers as a consequence of which they are engaged in unjust contracts. Their limited entitlements also limit their opportunities to engage in enriching goals. It is the role of the state to provide all its citizens with basic entitlements and protect their basic human rights. Individuals in India evading their basic duty also contribute to the existing inequalities. Individual responsibilities of the medical practitioners and the intended parents are in question here as they are more inclined towards self-interest rather than commitment towards human fellowship. At the global level, the injustice in transnational commercial surrogacy practices in developing countries calls for an international declaration of women and child rights in third party reproduction with a normative vision of mutual fellowship and human dignity.

The opportunities for space biology research on the Space Station

NASA Technical Reports Server (NTRS)

Ballard, Rodney W.; Souza, Kenneth A.

1987-01-01

The life sciences research facilities for the Space Station are being designed to accommodate both animal and plant specimens for long durations studies. This will enable research on how living systems adapt to microgravity, how gravity has shaped and affected life on earth, and further the understanding of basic biological phenomena. This would include multigeneration experiments on the effects of microgravity on the reproduction, development, growth, physiology, behavior, and aging of organisms. To achieve these research goals, a modular habitat system and on-board variable gravity centrifuges, capable of holding various animal, plant, cells and tissues, is proposed for the science laboratory.

Reference Mission Operational Analysis Document (RMOAD) for the Life Sciences Research Facilities

NASA Technical Reports Server (NTRS)

1987-01-01

The space station will be constructed during the next decade as an orbiting, low-gravity, permanent facility. The facility will provide a multitude of research opportunities for many different users. The pressurized research laboratory will allow life scientists to study the effects of long-term exposure to microgravity on humans, animals, and plants. The results of these studies will increase our understanding of this foreign environment on basic life processes and ensure the safety of man's long-term presence in space. This document establishes initial operational requirements for the use of the Life Sciences Research Facility (LSRF) during its construction.

Extending Basic Learning Opportunities: Challenge and Response. UNESCO-UNICEF Co-operative Programme Digest No. 16.

ERIC Educational Resources Information Center

Prakasha, Veda; And Others

This digest focuses on problems encountered in the expansion of facilities for universal primary education and responses being developed to overcome these problems. The central message of the document is that nonformal structures of learning and community involvement play a key role in the expansion of basic learning opportunities in the…

Concept Similarity in Publications Precedes Cross-disciplinary Collaboration

PubMed Central

Post, Andrew R.; Harrison, James H.

2008-01-01

Innovative science frequently occurs as a result of cross-disciplinary collaboration, the importance of which is reflected by recent NIH funding initiatives that promote communication and collaboration. If shared research interests between collaborators are important for the formation of collaborations, methods for identifying these shared interests across scientific domains could potentially reveal new and useful collaboration opportunities. MEDLINE represents a comprehensive database of collaborations and research interests, as reflected by article co-authors and concept content. We analyzed six years of citations using information retrieval-based methods to compute articles’ conceptual similarity, and found that articles by basic and clinical scientists who later collaborated had significantly higher average similarity than articles by similar scientists who did not collaborate. Refinement of these methods and characterization of found conceptual overlaps could allow automated discovery of collaboration opportunities that are currently missed. PMID:18999254

Summary report of a workshop on research opportunities in plant biochemistry, December 11--13, 1992, Kona, Hawaii

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1992-12-31

A DOE-sponsored workshop was held December 11--13, 1992 in Kona, Hawaii to discuss those aspects of fundamental research in plant biochemistry deemed essential to provide the basic information base necessary for exploiting plant biotechnology to meet future societal needs. Twenty nine scientists, with interests representing many of the various areas of plant biochemistry, participated. The workshop was intended to define in both broad and specific terms the current state of knowledge in the general area of metabolic biochemistry, and to identify those areas that afford unusual opportunity or that are relatively underdeveloped in comparison with other areas of plant biology.more » Participants provided critiques of the state of knowledge of the major areas of metabolic biochemistry in relation to a series of questions that are presented herein.« less

Toward Evidence-Based Chinese Medicine: Status Quo, Opportunities and Challenges.

PubMed

Chen, Yao-Long; Zhao, Chen; Zhang, Li; Li, Bo; Wu, Chuan-Hong; Mu, Wei; Wang, Jia-Ying; Yang, Ke-Hu; Li, You-Ping; Chen, Chiehfeng; Wang, Yong-Yan; Wang, Chen; Bian, Zhao-Xiang; Shang, Hong-Cai

2018-03-01

How to test the treatments of Chinese medicine (CM) and make them more widely accepted by practitioners of Western medicine and the international healthcare community is a major concern for practitioners and researchers of CM. For centuries, various approaches have been used to identify and measure the efficacy and safety of CM. However, the high-quality evidence related to CM that produced in China is still rare. Over the recent years, evidence-based medicine (EBM) has been increasingly applied to CM, strengthening its theoretical basis. This paper reviews the past and present state of CM, analyzes the status quo, challenges and opportunities of basic research, clinical trials, systematic reviews, clinical practice guidelines and clinical pathways and evidence-based education developed or conducted in China, pointing out how EBM can help to make CM more widely used and recognized worldwide.

Concept similarity in publications precedes cross-disciplinary collaboration.

PubMed

Post, Andrew R; Harrison, James H

2008-11-06

Innovative science frequently occurs as a result of cross-disciplinary collaboration, the importance of which is reflected by recent NIH funding initiatives that promote communication and collaboration. If shared research interests between collaborators are important for the formation of collaborations,methods for identifying these shared interests across scientific domains could potentially reveal new and useful collaboration opportunities. MEDLINE represents a comprehensive database of collaborations and research interests, as reflected by article co-authors and concept content. We analyzed six years of citations using information retrieval based methods to compute articles conceptual similarity, and found that articles by basic and clinical scientists who later collaborated had significantly higher average similarity than articles by similar scientists who did not collaborate.Refinement of these methods and characterization of found conceptual overlaps could allow automated discovery of collaboration opportunities that are currently missed.

Basic Science for a Secure Energy Future

NASA Astrophysics Data System (ADS)

Horton, Linda

2010-03-01

Anticipating a doubling in the world's energy use by the year 2050 coupled with an increasing focus on clean energy technologies, there is a national imperative for new energy technologies and improved energy efficiency. The Department of Energy's Office of Basic Energy Sciences (BES) supports fundamental research that provides the foundations for new energy technologies and supports DOE missions in energy, environment, and national security. The research crosses the full spectrum of materials and chemical sciences, as well as aspects of biosciences and geosciences, with a focus on understanding, predicting, and ultimately controlling matter and energy at electronic, atomic, and molecular levels. In addition, BES is the home for national user facilities for x-ray, neutron, nanoscale sciences, and electron beam characterization that serve over 10,000 users annually. To provide a strategic focus for these programs, BES has held a series of ``Basic Research Needs'' workshops on a number of energy topics over the past 6 years. These workshops have defined a number of research priorities in areas related to renewable, fossil, and nuclear energy -- as well as cross-cutting scientific grand challenges. These directions have helped to define the research for the recently established Energy Frontier Research Centers (EFRCs) and are foundational for the newly announced Energy Innovation Hubs. This overview will review the current BES research portfolio, including the EFRCs and user facilities, will highlight past research that has had an impact on energy technologies, and will discuss future directions as defined through the BES workshops and research opportunities.

Energy systems equipment market research in the Philippines. Foreign market survey report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1979-05-01

The market research was undertaken to study the present and potential US share of the market in the Philippines for energy systems equipment; to examine growth trends in the Philippines end-user industries over the next few years; to identify specific product categories that offer the most promising export potential for US companies; and to provide basic data which will assist US suppliers in determining current and potential sales and marketing opportunities. The trade promotional and marketing techniques which are likely to suceed in the Philippines were also reviewed.

Complex Plasma Physics and Rising Above the Gathering Storm

NASA Astrophysics Data System (ADS)

Hyde, Truell

2008-11-01

Research in complex plasma is prevalent across a variety of regimes ranging from the majority of plasma processing environments to many astrophysical settings. Dust particles suspended within such plasmas acquire a charge from collisions with electrons and ions in the plasma. Depending upon the ratio of their interparticle potential energy to their average kinetic energy, once charged these particles can form a gaseous, liquid or crystalline structure with short to longer range ordering. The field of complex plasmas thus offers research opportunities across a wide range of academic disciplines including physics, chemistry, biology, mathematics, electrical engineering and nanoscience. The field of complex plasmas also offers unique educational research opportunities for combating many of the issues raised in Rising Above the Gathering Storm, recently published by the National Academies Press. CASPER's Educational Outreach programs, supported by the National Science Foundation, the Department of Education and the Department of Labor takes advantage of these opportunities through a variety of avenues including a REU / RET program, a High School Scholars Program, integrated curriculum development and the CASPER Physics Circus. Together, these programs impact thousands of students and parents while providing K-12 teachers with curriculum, supporting hands-on material and support for introducing plasma and basic physical science concepts into the classroom. Both research results and educational outreach concepts from the above will be discussed.

Transdisciplinary translational behavioral (TDTB) research: opportunities, barriers, and innovations.

PubMed

Czajkowski, Susan M; Lynch, Minda R; Hall, Kara L; Stipelman, Brooke A; Haverkos, Lynne; Perl, Harold; Scott, Marcia S; Shirley, Mariela C

2016-03-01

The translation of basic behavioral science discoveries into practical strategies represents a promising approach to developing more effective preventive interventions to improve health. Since translational research inevitably involves making use of diverse perspectives from multiple disciplines, it is best conducted as a transdisciplinary enterprise. In this paper, we discuss current strategies used by NIH to support transdisciplinary translational behavioral (TDTB) research, summarize successful efforts, and highlight challenges encountered in conducting such work (ranging from conceptual to organizational to methodological). Using examples from NIH-funded projects we illustrate the potential benefits of, and barriers to, pursuing this type of research and discuss next steps and potential future directions for NIH-supported TDTB research.

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

Research is organized around two major programs: thermal and aquatic stress and mineral cycling. These programs are strengthened by a previously established foundation of basic ecological knowledge. Research in basic ecology continues to be a major component of all SREL environmental programs. Emphasis in all programs has been placed upon field-oriented research relating to regional and local problems having broad ecological significance. For example, extensive research has been conducted in the Par Pond reservoir system and the Savannah River swamp, both of which have received thermal effluent, heavy metals, and low levels of radioisotopes. Furthermore, the availability of low levelsmore » of plutonium and uranium in both terrestrial and aquatic environments on the Savannah River Plant (SRP) has provided an unusual opportunity for field research in this area. The studies seek to document the effects, to determine the extent of local environmental problems, and to establish predictable relationships which have general applicability. In order to accomplish this objective it has been imperative that studies be carried out in the natural, environmentally unaffected areas on the SRP as a vital part of the overall program. Progress is reported in forty-nine studies.« less

Behavioral and Social Sciences at the National Institutes of Health: adoption of research findings in health research and practice as a scientific priority.

PubMed

Riley, William T

2017-06-01

The National Institutes of Health's Office of Behavioral and Social Sciences Research (OBSSR) recently released its Strategic Plan for 2017 to 2021. This plan highlights three scientific priorities: (1) improve the synergy of basic and applied behavioral and social sciences research, (2) enhance and promote the research infrastructure, methods, and measures needed to support a more cumulative and integrated approach to behavioral and social sciences research, and (3) facilitate the adoption of behavioral and social sciences research findings in health research and in practice. This commentary focuses on the challenges and opportunities to facilitate the adoption of research findings in health research and in practice. In addition to the ongoing NIH support for dissemination and implementation (D&I) research, we must address transformative challenges and opportunities such as better disseminating and implementing D&I research, merging research and practice, adopting more rigorous and diverse methods and measures for both D&I and clinical trials research, evaluating technological-based delivery of interventions, and transitioning from minimally adaptable intervention packages to planned adaptations rooted in behavior change principles. Beyond translation into practice and policy, the OBSSR Strategic Plan also highlights the need for translation of behavioral and social science findings into the broader biomedical research enterprise.

From Nonclinical Research to Clinical Trials and Patient-registries: Challenges and Opportunities in Biomedical Research

PubMed Central

de la Torre Hernández, José M.; Edelman, Elazer R.

2018-01-01

The most important challenge faced by human beings is health. The only way to provide better solutions for health care is innovation, true innovation. The only source of true innovation is research, good research indeed. The pathway from a basic science study to a randomized clinical trial is long and not free of bumps and even landmines. These are all the obstacles and barriers that limit the availability of resources, entangle administrative-regulatory processes, and restrain investigators’ initiatives. There is increasing demand for evidence to guide clinical practice but, paradoxically, biomedical research has become increasingly complex, expensive, and difficult to integrate into clinical care with increased barriers to performing the practical aspects of investigation. We face the challenge of increasing the volume of biomedical research and simultaneously improving the efficiency and output of this research. In this article, we review the main stages and methods of biomedical research, from nonclinical studies with animal and computational models to randomized trials and clinical registries, focusing on their limitations and challenges, but also providing alternative solutions to overcome them. Fortunately, challenges are always opportunities in disguise. PMID:28838647

The relationships among three factors affecting the financial decision-making abilities of adults with mild intellectual disabilities.

PubMed

Suto, W M I; Clare, I C H; Holland, A J; Watson, P C

2005-03-01

Among adults with intellectual disabilities (IDs), there is a need not only to assess financial decision-making capacity, but also to understand how it can be maximized. Although increased financial independence is a goal for many people, it is essential that individuals' decision-making abilities are sufficient, and many factors may affect the development of such abilities. As part of a wider project on financial decision-making, we analysed previous data from a group of 30 adults with mild IDs, identifying correlations among four variables: (i) financial decision-making abilities; (ii) intellectual ability; (iii) understanding of some basic concepts relevant to finance; and (iv) decision-making opportunities in everyday life. The analysis indicated a direct relationship between ID and basic financial understanding. Strong relationships of a potentially reciprocal nature were identified between basic financial understanding and everyday decision-making opportunities, and between such opportunities and financial decision-making abilities. The findings suggest that the role of intellectual ability in determining financial decision-making abilities is only indirect, and that access to both basic skills education and everyday decision-making opportunities is crucial for maximizing capacity. The implications of this are discussed.

Forty years of progress.

PubMed

Löe, H

1989-05-01

The celebration of the 40th anniversary of the National Institute of Dental Research (NIDR) provides an opportunity for reviewing the growth of dental research over the decades. The Institute owes its origin to public and professional concern over the dental health of Americans and the prospect that a Federal investment in dental research could pay off. The early years of the Institute were devoted to studies of fluoride and dental caries, with notable achievements in clinical trials of water fluoridation and caries microbiology. During the 1960s came the discovery that the periodontal diseases, like dental caries, were bacterial infections that could be prevented. Basic and clinical research expanded, and the research manpower pool grew with the addition of microbiologists, immunologists, salivary gland investigators, and other basic biomedical and behavioral scientists. The Institute created special broad-based Dental Research Institutes and Centers to foster interdisciplinary research, and continued to expand its research base. A national survey undertaken by NIDR in the late 1970s showed major declines in caries prevalence in schoolchildren. Recent NIDR surveys of adults and older Americans as well as a second children's survey have demonstrated overall improvements in oral health and a continued decline in childhood caries.(ABSTRACT TRUNCATED AT 250 WORDS)

Genomics pipelines and data integration: challenges and opportunities in the research setting

PubMed Central

Davis-Turak, Jeremy; Courtney, Sean M.; Hazard, E. Starr; Glen, W. Bailey; da Silveira, Willian; Wesselman, Timothy; Harbin, Larry P.; Wolf, Bethany J.; Chung, Dongjun; Hardiman, Gary

2017-01-01

Introduction The emergence and mass utilization of high-throughput (HT) technologies, including sequencing technologies (genomics) and mass spectrometry (proteomics, metabolomics, lipids), has allowed geneticists, biologists, and biostatisticians to bridge the gap between genotype and phenotype on a massive scale. These new technologies have brought rapid advances in our understanding of cell biology, evolutionary history, microbial environments, and are increasingly providing new insights and applications towards clinical care and personalized medicine. Areas covered The very success of this industry also translates into daunting big data challenges for researchers and institutions that extend beyond the traditional academic focus of algorithms and tools. The main obstacles revolve around analysis provenance, data management of massive datasets, ease of use of software, interpretability and reproducibility of results. Expert Commentary The authors review the challenges associated with implementing bioinformatics best practices in a large-scale setting, and highlight the opportunity for establishing bioinformatics pipelines that incorporate data tracking and auditing, enabling greater consistency and reproducibility for basic research, translational or clinical settings. PMID:28092471

KSC-2011-6855

NASA Image and Video Library

2011-09-09

CAPE CANAVERAL, Fla. – Panelists conduct a question and answer session with news media after NASA awards a cooperative agreement with the Center for the Advancement of Science in Space (CASIS) to manage the portion of the International Space Station that operates as a U.S. national laboratory. From left are: Waleed Abdalati, NASA chief scientist; Mark Uhran, NASA assistant associate administrator for the International Space Station; and Jeanne Becker, CASIS executive director. CASIS will be located at the Space Life Sciences Laboratory at NASA’s Kennedy Space Center in Florida. The organization will increase station use to maximize the public’s return on its investment by managing its diversified research and development portfolio based on needs for basic and applied research in a variety of fields. CASIS will identify opportunities for non-NASA uses linking scientific review and economic value, and will match potential research and development opportunities with funding sources. The organization also will increase awareness among schools and students about using the station as a learning platform. Photo credit: NASA/Kim Shiflett

Genomics pipelines and data integration: challenges and opportunities in the research setting.

PubMed

Davis-Turak, Jeremy; Courtney, Sean M; Hazard, E Starr; Glen, W Bailey; da Silveira, Willian A; Wesselman, Timothy; Harbin, Larry P; Wolf, Bethany J; Chung, Dongjun; Hardiman, Gary

2017-03-01

The emergence and mass utilization of high-throughput (HT) technologies, including sequencing technologies (genomics) and mass spectrometry (proteomics, metabolomics, lipids), has allowed geneticists, biologists, and biostatisticians to bridge the gap between genotype and phenotype on a massive scale. These new technologies have brought rapid advances in our understanding of cell biology, evolutionary history, microbial environments, and are increasingly providing new insights and applications towards clinical care and personalized medicine. Areas covered: The very success of this industry also translates into daunting big data challenges for researchers and institutions that extend beyond the traditional academic focus of algorithms and tools. The main obstacles revolve around analysis provenance, data management of massive datasets, ease of use of software, interpretability and reproducibility of results. Expert commentary: The authors review the challenges associated with implementing bioinformatics best practices in a large-scale setting, and highlight the opportunity for establishing bioinformatics pipelines that incorporate data tracking and auditing, enabling greater consistency and reproducibility for basic research, translational or clinical settings.

Meeting the need for regenerative therapies I: target-based incidence and its relationship to U.S. spending, productivity, and innovation.

PubMed

Parenteau, Nancy; Hardin-Young, Janet; Shannon, William; Cantini, Patrick; Russell, Alan

2012-04-01

Regenerative therapies possess high theoretical potential for medical advance yet their success as commercial therapeutics is still open to debate. Appropriate data on target opportunities that provide perspective and enable strategic decision making is necessary for both efficient and effective translation. Up until now, this data have been out of reach to research scientists and many start-up companies-the very groups currently looked to for the critical advance of these therapies. The target-based estimate of opportunity presented in this report demonstrates its importance in evaluating medical need and technology feasibility. In addition, analysis of U.S. research spending, productivity, and innovation reveals that U.S. basic research in this field would benefit from greater interdisciplinarity. Overcoming the barriers that currently prevent translation into high value therapies that are quickly clinically adopted requires simultaneous integration of engineering, science, business, and clinical practice. Achieving this integration is nontrivial.

Integrating utilization-focused evaluation with business process modeling for clinical research improvement.

PubMed

Kagan, Jonathan M; Rosas, Scott; Trochim, William M K

2010-10-01

New discoveries in basic science are creating extraordinary opportunities to design novel biomedical preventions and therapeutics for human disease. But the clinical evaluation of these new interventions is, in many instances, being hindered by a variety of legal, regulatory, policy and operational factors, few of which enhance research quality, the safety of study participants or research ethics. With the goal of helping increase the efficiency and effectiveness of clinical research, we have examined how the integration of utilization-focused evaluation with elements of business process modeling can reveal opportunities for systematic improvements in clinical research. Using data from the NIH global HIV/AIDS clinical trials networks, we analyzed the absolute and relative times required to traverse defined phases associated with specific activities within the clinical protocol lifecycle. Using simple median duration and Kaplan-Meyer survival analysis, we show how such time-based analyses can provide a rationale for the prioritization of research process analysis and re-engineering, as well as a means for statistically assessing the impact of policy modifications, resource utilization, re-engineered processes and best practices. Successfully applied, this approach can help researchers be more efficient in capitalizing on new science to speed the development of improved interventions for human disease.

Supporting Latino communities' natural helpers: a case study of promotoras in a research capacity building course.

PubMed

Otiniano, Angie Denisse; Carroll-Scott, Amy; Toy, Peggy; Wallace, Steven P

2012-08-01

Promotores have unique access to underserved and hard-to-reach Latino communities facing health disparities. Although promotores are involved in community change, they rarely receive training that gives them the skills to be partners in research. We present a case study of promotoras who participated in a research capacity building course focused on assessing community health needs. Data comes from course application surveys, follow-up notes, and narratives from qualitative phone interviews of eight promotoras. Content analysis drawing from grounded theory was conducted to identify and describe emerging themes. Four themes emerged as promotoras discussed their experience learning basic research skills and teaching others: (1) challenges, (2) support, (3) building capacity, and (4) using research. Promotores play an important role in the health of Latino communities and are increasingly asked to participate in research processes; however they have few opportunities for training and professional development in this area. Capacity building opportunities for promotores need to be tailored to their needs and provide them with support. Fostering collaboration between promotores and partnering with local community-based organizations can help facilitate needed research skill-building among promotores.

Get Involved in the Job Opportunities and Basic Skills Training Program (JOBS). What Local Areas Need To Know.

ERIC Educational Resources Information Center

JTPA Issues, 1989

1989-01-01

This Job Training Partnership Act (JTPA) Update provides a quick primer of some of the key areas where states have flexibility to develop their own programs and processes in the new Job Opportunities and Basic Skills (JOBS) program. This guide is organized in seven sections that cover the following topics: (1) introduction; (2) why local areas…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pierce, Eric M.; Freshley, Mark D.; Hubbard, Susan S.

In this report, we start by examining previous efforts at linking science and DOE EM research with cleanup activities. Many of these efforts were initiated by creating science and technology roadmaps. A recurring feature of successfully implementing these roadmaps into EM applied research efforts and successful cleanup is the focus on integration. Such integration takes many forms, ranging from combining information generated by various scientific disciplines, to providing technical expertise to facilitate successful application of novel technology, to bringing the resources and creativity of many to address the common goal of moving EM cleanup forward. Successful projects identify and focusmore » research efforts on addressing the problems and challenges that are causing “failure” in actual cleanup activities. In this way, basic and applied science resources are used strategically to address the particular unknowns that are barriers to cleanup. The brief descriptions of the Office of Science basic (Environmental Remediation Science Program [ERSP]) and EM’s applied (Groundwater and Soil Remediation Program) research programs in subsurface science provide context to the five “crosscutting” themes that have been developed in this strategic planning effort. To address these challenges and opportunities, a tiered systematic approach is proposed that leverages basic science investments with new applied research investments from the DOE Office of Engineering and Technology within the framework of the identified basic science and applied research crosscutting themes. These themes are evident in the initial portfolio of initiatives in the EM groundwater and soil cleanup multi-year program plan. As stated in a companion document for tank waste processing (Bredt et al. 2008), in addition to achieving its mission, DOE EM is experiencing a fundamental shift in philosophy from driving to closure to enabling the long-term needs of DOE and the nation.« less

Research opportunities with compact accelerator-driven neutron sources

NASA Astrophysics Data System (ADS)

Anderson, I. S.; Andreani, C.; Carpenter, J. M.; Festa, G.; Gorini, G.; Loong, C.-K.; Senesi, R.

2016-10-01

Since the discovery of the neutron in 1932 neutron beams have been used in a very broad range of applications, As an aging fleet of nuclear reactor sources is retired the use of compact accelerator-driven neutron sources (CANS) is becoming more prevalent. CANS are playing a significant and expanding role in research and development in science and engineering, as well as in education and training. In the realm of multidisciplinary applications, CANS offer opportunities over a wide range of technical utilization, from interrogation of civil structures to medical therapy to cultural heritage study. This paper aims to provide the first comprehensive overview of the history, current status of operation, and ongoing development of CANS worldwide. The basic physics and engineering regarding neutron production by accelerators, target-moderator systems, and beam line instrumentation are introduced, followed by an extensive discussion of various evolving applications currently exploited at CANS.

Microgravity research in plant biological systems: Realizing the potential of molecular biology

NASA Technical Reports Server (NTRS)

Lewis, Norman G.; Ryan, Clarence A.

1993-01-01

The sole all-pervasive feature of the environment that has helped shape, through evolution, all life on Earth is gravity. The near weightlessness of the Space Station Freedom space environment allows gravitational effects to be essentially uncoupled, thus providing an unprecedented opportunity to manipulate, systematically dissect, study, and exploit the role of gravity in the growth and development of all life forms. New and exciting opportunities are now available to utilize molecular biological and biochemical approaches to study the effects of microgravity on living organisms. By careful experimentation, we can determine how gravity perception occurs, how the resulting signals are produced and transduced, and how or if tissue-specific differences in gene expression occur. Microgravity research can provide unique new approaches to further our basic understanding of development and metabolic processes of cells and organisms, and to further the application of this new knowledge for the betterment of humankind.

Multidisciplinary Techniques and Novel Aircraft Control Systems

NASA Technical Reports Server (NTRS)

Padula, Sharon L.; Rogers, James L.; Raney, David L.

2000-01-01

The Aircraft Morphing Program at NASA Langley Research Center explores opportunities to improve airframe designs with smart technologies. Two elements of this basic research program are multidisciplinary design optimization (MDO) and advanced flow control. This paper describes examples where MDO techniques such as sensitivity analysis, automatic differentiation, and genetic algorithms contribute to the design of novel control systems. In the test case, the design and use of distributed shape-change devices to provide low-rate maneuvering capability for a tailless aircraft is considered. The ability of MDO to add value to control system development is illustrated using results from several years of research funded by the Aircraft Morphing Program.

Multidisciplinary Techniques and Novel Aircraft Control Systems

NASA Technical Reports Server (NTRS)

Padula, Sharon L.; Rogers, James L.; Raney, David L.

2000-01-01

The Aircraft Morphing Program at NASA Langley Research Center explores opportunities to improve airframe designs with smart technologies. Two elements of this basic research program are multidisciplinary design optimization (MDO) and advanced flow control. This paper describes examples where MDO techniques such as sensitivity analysis, automatic differentiation, and genetic algorithms contribute to the design of novel control systems. In the test case, the design and use of distributed shapechange devices to provide low-rate maneuvering capability for a tailless aircraft is considered. The ability of MDO to add value to control system development is illustrated using results from several years of research funded by the Aircraft Morphing Program.

The impact of choice on retributive reactions: how observers' autonomy concerns shape responses to criminal offenders.

PubMed

van Prooijen, Jan-Willem; Kerpershoek, Emiel F P

2013-06-01

The present research examined the psychological origins of retributive reactions, which are defined as independent observers' anger-based emotions, demonized perceptions, and punishment intentions in response to criminal offenders. Based on the idea that society's justice system has an autonomy-protective function, we reason that chronic autonomy interacts with situational autonomy cues (i.e., opportunities to make choices) to predict retributive reactions to criminal offenders. More specifically, we hypothesized that choice opportunities in an unrelated decision-making context would prompt people to display stronger retributive reactions to offenders than no-choice opportunities, and that these effects of choice would be particularly pronounced among people who chronically experience deprivation of autonomy needs. Results from two experiments supported this hypothesis. It is concluded that retributive reactions to criminal offenders originate from a desire to regulate basic autonomy needs. © 2011 The British Psychological Society.

Keeping the exotic pet mentally healthy.

PubMed

Clayton, Leigh Ann; Tynes, Valarie V

2015-05-01

When basic needs are not met, captive animal health and welfare will be compromised by physical and psychological stressors. These basic needs include more than just appropriate food, water, and shelter; they should include environments that provide the animal with opportunities to thrive. These opportunities to thrive can be categorized as opportunity for a well-balanced diet (including how it is provided), to self-maintain, for optimal health, to express species-specific behaviors, and for choice and control. Adequate planning and knowledge are critical to creating environments in which animals can thrive. Copyright © 2015 Elsevier Inc. All rights reserved.

Basic research for the future: Opportunities in microbiology for the coming decade

DOE Office of Scientific and Technical Information (OSTI.GOV)

Payne, W.J.

1996-12-31

Not since Leeuwenhoek reported finding {open_quotes}animalcules{close_quotes} in a variety of natural materials have research opportunities in microbiology looked so promising. Researchers have developed methods to analyze the historic and evolutionary progression of bacteria, fungi, and viruses. The significance of the remarkable diversity found in the microbial realm is just beginning to emerge. Biotechnology companies are exploiting microorganisms in remarkable ways. Seemingly new, devastating pathogens have appeared and {open_quotes}old{close_quotes} pathogens have become resistant to antiobiotics. All these factors serve to invigorate interest in microbiology. Seldom have the challenges seemed more intense or more exciting. Recognizing the significance of these issues, themore » American Academy of Microbiology convened a colloquium of experts in the microbiological sciences May 4-7, 1996, in Washington, D.C. The colloquim sought primarily to identify those research areas most clearly deserving future attention, those most likely to provide optimal return on scientific and monetary investment, and those offering the greatest promise for solving critical problems over the coming decade.« less

SSERVI Analog Regolith Simulant Testbed Facility

NASA Astrophysics Data System (ADS)

Minafra, J.; Schmidt, G. K.

2016-12-01

SSERVI's goals include supporting planetary researchers within NASA, other government agencies; private sector and hardware developers; competitors in focused prize design competitions; and academic sector researchers. The SSERVI Analog Regolith Simulant Testbed provides opportunities for research scientists and engineers to study the effects of regolith analog testbed research in the planetary exploration field. This capability is essential to help to understand the basic effects of continued long-term exposure to a simulated analog test environment. The current facility houses approximately eight tons of JSC-1A lunar regolith simulant in a test bin consisting of a 4 meter by 4 meter area. SSERVI provides a bridge between several groups, joining together researchers from: 1) scientific and exploration communities, 2) multiple disciplines across a wide range of planetary sciences, and 3) domestic and international communities and partnerships. This testbed provides a means of consolidating the tasks of acquisition, storage and safety mitigation in handling large quantities of regolith simulant Facility hardware and environment testing scenarios include, but are not limited to the following; Lunar surface mobility, Dust exposure and mitigation, Regolith handling and excavation, Solar-like illumination, Lunar surface compaction profile, Lofted dust, Mechanical properties of lunar regolith, and Surface features (i.e. grades and rocks) Numerous benefits vary from easy access to a controlled analog regolith simulant testbed, and planetary exploration activities at NASA Research Park, to academia and expanded commercial opportunities in California's Silicon Valley, as well as public outreach and education opportunities.

Primary care research--a blueprint for action for Singapore.

PubMed

Chuan, T N; Gan, G L

2001-01-01

Primary care research, hitherto overshadowed by research in the tertiary institutions, lacks impetus due to image, limitations of resources and poor infrastructure. This article looks into the current state of research development and the barriers. These hurdles can be overcome by a paradigm shift through the initiation of regular research meetings, training, infrastructure support and a collaborative research network to optimize time and resources. This will open the door to a wide field of primary care research, from basic, clinical research to health service and health system analysis and evaluation. Family physicians can tap on this opportunity to sharpen their critical appraisal skills through research, which can form an integral part of their continuous professional development. A network of pro-research family physicians will foster a vibrant research culture and pave the way to a renaissance of primary care research.

Opportunities Unlimited: Minnesota Indians Adult Basic Education; Narrative and Statistical Evaluation Third Year 1971-72, with a Review of the First and Second Years.

ERIC Educational Resources Information Center

Vizenor, Gerald

Opportunities Unlimited is a State-wide program to provide adult basic education (ABE) and training for Indians on Minnesota reservations and in Indian communities. An administrative center in Bemidji serves communities on the Red Lake, White Earth, and Leech Lake Reservations, and a Duluth center provides ABE and training for communities on the…

Garrison Institute on Aging: A New Hope for Elderly Individuals and Patients with Alzheimer's Disease.

PubMed

Reddy, P Hemachandra; Blackmon, Joan; Molinar-Lopez, Veronica; Ament, Clay; Manczak, Maria; Kandimalla, Ramesh; Yin, Xianglin; Pandey, Akhilesh; Kuruva, Chandra Sekhar; Wang, Rui; Fry, David; Osborn, Carrah; Stonum, Kathleen; Quesada, Kandi; Gonzales, Ruben; Boles, Annette

2015-01-01

The Garrison Institute on Aging (GIA) is an established institute within Texas Tech University Health Sciences Center, whose mission is to promote healthy aging through cutting-edge research on Alzheimer's disease (AD) and other diseases of aging through innovative educational opportunities for students, clinicians, researchers, health care professionals, and the public. The GIA has multiple programs, including both research and education on healthy aging and AD, community outreach, caregiving, the Retired Senior Volunteer Program, Healthy Lubbock, the GIA Brain Bank, healthy aging seminars, research seminars, and collaborations and scholarships. The GIA programs connect basic and clinical researchers and health care professionals, and provide a unique environment to help our growing elderly population and patients with AD and their families.

OBPR Product Lines, Human Research Initiative, and Physics Roadmap for Exploration

NASA Technical Reports Server (NTRS)

Israelsson, Ulf

2004-01-01

The pace of change has increased at NASA. OBPR s focus is now on the Human interface as it relates to the new Exploration vision. The fundamental physics community must demonstrate how we can contribute. Many opportunities exist for physicists to participate in addressing NASA's cross-disciplinary exploration challenges: a) Physicists can contribute to elucidating basic operating principles for complex biological systems; b) Physics technologies can contribute to developing miniature sensors and systems required for manned missions to Mars. NASA Codes other than OBPR may be viable sources of funding for physics research.

Analysis of live cell images: Methods, tools and opportunities.

PubMed

Nketia, Thomas A; Sailem, Heba; Rohde, Gustavo; Machiraju, Raghu; Rittscher, Jens

2017-02-15

Advances in optical microscopy, biosensors and cell culturing technologies have transformed live cell imaging. Thanks to these advances live cell imaging plays an increasingly important role in basic biology research as well as at all stages of drug development. Image analysis methods are needed to extract quantitative information from these vast and complex data sets. The aim of this review is to provide an overview of available image analysis methods for live cell imaging, in particular required preprocessing image segmentation, cell tracking and data visualisation methods. The potential opportunities recent advances in machine learning, especially deep learning, and computer vision provide are being discussed. This review includes overview of the different available software packages and toolkits. Copyright © 2017. Published by Elsevier Inc.

The development of motor behavior

PubMed Central

Adolph, Karen E.; Franchak, John M.

2016-01-01

This article reviews research on the development of motor behavior from a developmental systems perspective. We focus on infancy when basic action systems are acquired. Posture provides a stable base for locomotion, manual actions, and facial actions. Experience facilitates improvements in motor behavior and infants accumulate immense amounts of experience with all of their basic action systems. At every point in development, perception guides motor behavior by providing feedback about the results of just prior movements and information about what to do next. Reciprocally, the development of motor behavior provides fodder for perception. More generally, motor development brings about new opportunities for acquiring knowledge about the world, and burgeoning motor skills can instigate cascades of developmental changes in perceptual, cognitive, and social domains. PMID:27906517

Population Disparities in Mental Health: Insights From Cultural Neuroscience

PubMed Central

Blizinsky, Katherine D.

2013-01-01

By 2050, nearly 1 in 5 Americans (19%) will be an immigrant, including Hispanics, Blacks, and Asians, compared to the 1 in 8 (12%) in 2005. They will vary in the extent to which they are at risk for mental health disorders. Given this increase in cultural diversity within the United States and costly population health disparities across cultural groups, it is essential to develop a more comprehensive understanding of how culture affects basic psychological and biological mechanisms. We examine these basic mechanisms that underlie population disparities in mental health through cultural neuroscience. We discuss the challenges to and opportunities for cultural neuroscience research to determine sociocultural and biological factors that confer risk for and resilience to mental health disorders across the globe. PMID:23927543

Population disparities in mental health: insights from cultural neuroscience.

PubMed

Chiao, Joan Y; Blizinsky, Katherine D

2013-10-01

By 2050, nearly 1 in 5 Americans (19%) will be an immigrant, including Hispanics, Blacks, and Asians, compared to the 1 in 8 (12%) in 2005. They will vary in the extent to which they are at risk for mental health disorders. Given this increase in cultural diversity within the United States and costly population health disparities across cultural groups, it is essential to develop a more comprehensive understanding of how culture affects basic psychological and biological mechanisms. We examine these basic mechanisms that underlie population disparities in mental health through cultural neuroscience. We discuss the challenges to and opportunities for cultural neuroscience research to determine sociocultural and biological factors that confer risk for and resilience to mental health disorders across the globe.

ENHANCING RESEARCH ETHICS REVIEW SYSTEMS IN EGYPT: THE FOCUS OF AN INTERNATIONAL TRAINING PROGRAM INFORMED BY AN ECOLOGICAL DEVELOPMENTAL APPROACH TO ENHANCING RESEARCH ETHICS CAPACITY

PubMed Central

Edwards, Hillary Anne; Hifnawy, Tamer; Silverman, Henry

2014-01-01

Recently, training programs in research ethics have been established to enhance individual and institutional capacity in research ethics in the developing world. However, commentators have expressed concern that the efforts of these training programs have placed “too great an emphasis on guidelines and research ethics review”, which will have limited effect on ensuring ethical conduct in research. What is needed instead is a culture of ethical conduct supported by national and institutional commitment to ethical practices that are reinforced by upstream enabling conditions (strong civil society, public accountability, and trust in basic transactional processes), which are in turn influenced by developmental conditions (basic freedoms of political freedoms, economic facilities, social opportunities, transparency guarantees, and protective security). Examining this more inclusive understanding of the determinants of ethical conduct enhances at once both an appreciation of the limitations of current efforts of training programs in research ethics and an understanding of what additional training elements are needed to enable trainees to facilitate national and institutional policy changes that enhance research practices. We apply this developmental model to a training program focused in Egypt to describe examples of such additional training activities. PMID:24894063

Enhancing Research Ethics Review Systems in Egypt: The Focus of an International Training Program Informed by an Ecological Developmental Approach to Enhancing Research Ethics Capacity.

PubMed

Edwards, Hillary Anne; Hifnawy, Tamer; Silverman, Henry

2015-12-01

Recently, training programs in research ethics have been established to enhance individual and institutional capacity in research ethics in the developing world. However, commentators have expressed concern that the efforts of these training programs have placed 'too great an emphasis on guidelines and research ethics review', which will have limited effect on ensuring ethical conduct in research. What is needed instead is a culture of ethical conduct supported by national and institutional commitment to ethical practices that are reinforced by upstream enabling conditions (strong civil society, public accountability, and trust in basic transactional processes), which are in turn influenced by developmental conditions (basic freedoms of political freedoms, economic facilities, social opportunities, transparency guarantees, and protective security). Examining this more inclusive understanding of the determinants of ethical conduct enhances at once both an appreciation of the limitations of current efforts of training programs in research ethics and an understanding of what additional training elements are needed to enable trainees to facilitate national and institutional policy changes that enhance research practices. We apply this developmental model to a training program focused in Egypt to describe examples of such additional training activities. © 2014 John Wiley & Sons Ltd.

Mixed methods in gerontological research: Do the qualitative and quantitative data “touch”?

PubMed Central

Happ, Mary Beth

2010-01-01

This paper distinguishes between parallel and integrated mixed methods research approaches. Barriers to integrated mixed methods approaches in gerontological research are discussed and critiqued. The author presents examples of mixed methods gerontological research to illustrate approaches to data integration at the levels of data analysis, interpretation, and research reporting. As a summary of the methodological literature, four basic levels of mixed methods data combination are proposed. Opportunities for mixing qualitative and quantitative data are explored using contemporary examples from published studies. Data transformation and visual display, judiciously applied, are proposed as pathways to fuller mixed methods data integration and analysis. Finally, practical strategies for mixing qualitative and quantitative data types are explicated as gerontological research moves beyond parallel mixed methods approaches to achieve data integration. PMID:20077973

Progress in the Utilization of High-Fidelity Simulation in Basic Science Education

ERIC Educational Resources Information Center

Helyer, Richard; Dickens, Peter

2016-01-01

High-fidelity patient simulators are mainly used to teach clinical skills and remain underutilized in teaching basic sciences. This article summarizes our current views on the use of simulation in basic science education and identifies pitfalls and opportunities for progress.

NHLBI workshop: respiratory medicine-related research training for adult and pediatric fellows.

PubMed

Choi, Augustine M K; Reynolds, Herbert Y; Colombini-Hatch, Sandra; Rothgeb, Ann; Blaisdell, Carol J; Gail, Dorothy B

2009-01-01

The pulmonary physician-scientist has a special niche to generate basic research findings and apply them to a clinical disease and perhaps impact its medical care. The availability of new high throughput-based scientific technologies in the "omics era" has made this an opportune time for physician scientists to prepare and embark on an academic career in respiratory disease research. However, maintaining an adequate flow through the research pipeline of physician-scientist investigators studying respiratory system diseases is currently a challenge. There may not be a sufficient workforce emerging to capitalize on current research opportunities. The National Heart, Lung, and Blood Institute (NHLBI) organized a workshop to assess ways to attract and properly train advanced fellows to pursue research careers in adult and pediatric lung diseases. Participants included representatives from the various pulmonary training programs, respiratory-related professional societies, and NHLBI staff. Deliberation centered on present barriers that might affect interest in pursuing research training, devising better incentives to attract more trainees, and how current research support offered by the NHLBI and the Professional Societies (in partnership with Industry and Patient Support groups) might be better coordinated and optimized to ensure a continued pipeline of pulmonary investigators. Major recommendations offered are: (1) Attract trainees to pulmonary/critical care medicine-based research careers by increasing research exposure and opportunities for high school, college, and medical students. (2) Increase awareness of the outstanding physician-scientist role models in the lung community for trainees. (3) Facilitate mechanisms by which the lung community (NHLBI, professional societies, and partners) can better support and bridge senior fellows as they transition from Institutional Training Grants (T32) to Career Series (K) awards in their early faculty career development.

Opportunities for Multidisciplinary Research in Partnership with Rock Engineers at the Deep Underground Science and Engineering Laboratory

NASA Astrophysics Data System (ADS)

Laughton, C.

2008-12-01

For the last half century the physics community has increasingly turned to the use of underground space to conduct basic research. The community is currently planning to conduct a new generation of underground experiments at the Deep Underground Science and Engineering Laboratory (DUSEL). DUSEL will be constructed within the footprint of the defunct Homestake Gold Mine, located in Lead, South Dakota. Physics proposals call for the construction of new caverns in which to conduct major new experiments. Some of the proposed laboratory facilities will be significantly larger and deeper than any previously constructed. The talk will highlight possible opportunities for integrating multi-disciplinary research in to the cavern construction program, and will stress the need to work closely with design and construction contractors to ensure that research goals can be achieve with minimal impact on project work. The constructors of large caverns should be particularly receptive to, and encouraging of geoscience research that could improve the engineering characterization of the rock mass. An improved understanding of the rock mass, as the host construction material, would result in a more reliable cavern design and construction process, and a reduced construction risk to the Project.

Translational genetics: advancing fronts for craniofacial health.

PubMed

D'Souza, R N; Dunnwald, M; Dunnvald, M; Frazier-Bowers, S; Polverini, P J; Wright, J T; de Rouen, T; Vieira, A R

2013-12-01

Scientific opportunities have never been better than today! The completion of the Human Genome project has sparked hope and optimism that cures for debilitating conditions can be achieved and tailored to individuals and communities. The availability of reference genome sequences and genetic variations as well as more precise correlations between genotype and phenotype have facilitated the progress made in finding solutions to clinical problems. While certain craniofacial and oral diseases previously deemed too difficult to tackle have benefited from basic science and technological advances over the past decade, there remains a critical need to translate the fruits of several decades' worth of basic and clinical research into tangible therapies that can benefit patients. The fifth Annual Fall Focused Symposium, "Translational Genetics - Advancing Fronts for Craniofacial Health", was created by the American Association for Dental Research (AADR) to foster its mission to advance interdisciplinary research that is directed toward improving oral health. The symposium showcased progress made in identifying molecular targets that are potential therapeutics for common and rare dental diseases and craniofacial disorders. Speakers focused on translational and clinical applications of their research and, where applicable, on strategies for new technologies and therapeutics. The critical needs to transfer new knowledge to the classroom and for further investment in the field were also emphasized. The symposium underscored the importance of basic research, chairside clinical observations, and population-based studies in driving the new translational connections needed for the development of cures for the most common and devastating diseases involving the craniofacial complex.

An Analysis of Future Publications, Career Choices, and Practice Characteristics of Research Presenters at an American College of Surgeons State Conference: A 15-Year Review.

PubMed

Ahmad, Humera F; Jarman, Benjamin T; Kallies, Kara J; Shapiro, Stephen B

The Accreditation Council for Graduate Medical Education requires scholarly activity within general surgery residency programs. The association between in-training research presentations and postgraduation publications is unknown. We hypothesized that surgical trainee presentations at an American College of Surgeons (ACS) state chapter meeting resulted in peer-reviewed publications and future scholarly activity. The ACS Wisconsin state chapter meeting agendas from 2000 to 2014 were reviewed to identify all trainees who delivered podium presentations. A literature search was completed for subsequent publications. Program coordinators were queried and an electronic search was performed to determine practice location and type for each residency graduate. Wisconsin state chapter ACS meeting. General surgery residents, fellows, and medical students in Wisconsin. There were 288 podium presentations by trainees (76% residents, 20% medical students, and 4% fellows). Presentations were clinical (79.5%) and basic science (20.5%). There were 204 unique presenters; 25% presented at subsequent meetings. Of these unique presenters, 46% published their research and 31% published additional research after residency. Among presenters who completed residency or fellowship (N = 119), 34% practiced in a university setting, and 61% practiced in a community setting; 31% practiced in Wisconsin. When comparing clinical vs basic science presenters, there was no difference in fellowship completion (37% vs 44%; p = 0.190) or practice type (38% vs 46% in a university setting; p = 0.397). Repeat presenters were more likely to pursue a fellowship vs those presenting once (76% vs 37%; p = 0.001). Research presentations by surgical trainees at an ACS state chapter meeting frequently led to peer-reviewed publications. Presenters were likely to pursue research opportunities after residency. Repeat presenters were more likely to pursue a fellowship. ACS Wisconsin chapter meetings provide an excellent opportunity for scholarly activity. These outcomes should encourage ACS chapters and ACS members to support trainee research. Copyright © 2017 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

Curriculum Development of a Research Laboratory Methodology Course for Complementary and Integrative Medicine Students

PubMed Central

Vasilevsky, Nicole; Schafer, Morgan; Tibbitts, Deanne; Wright, Kirsten; Zwickey, Heather

2015-01-01

Training in fundamental laboratory methodologies is valuable to medical students because it enables them to understand the published literature, critically evaluate clinical studies, and make informed decisions regarding patient care. It also prepares them for research opportunities that may complement their medical practice. The National College of Natural Medicine's (NCNM) Master of Science in Integrative Medicine Research (MSiMR) program has developed an Introduction to Laboratory Methods course. The objective of the course it to train clinical students how to perform basic laboratory skills, analyze and manage data, and judiciously assess biomedical studies. Here we describe the course development and implementation as it applies to complementary and integrative medicine students. PMID:26500806

Introduction to Welding.

ERIC Educational Resources Information Center

Fortney, Clarence; Gregory, Mike

This curriculum guide provides six units of instruction on basic welding. Addressed in the individual units of instruction are the following topics: employment opportunities for welders, welding safety and first aid, welding tools and equipment, basic metals and metallurgy, basic math and measuring, and procedures for applying for a welding job.…

An Opportunity to Learn US History: What NAEP Data Suggest Regarding the Opportunity Gap

ERIC Educational Resources Information Center

Heafner, Tina L.; Fitchett, Paul G.

2015-01-01

The purpose of this study is to determine the degree to which Opportunity to Learn (OTL), is associated with students' achievement in US History. Opportunity to Learn stems from the basic premise that there is an important relationship between the quality and frequency of classroom instruction and students' levels of academic success. The authors…

[Organization of clinical research: in general and visceral surgery].

PubMed

Schneider, M; Werner, J; Weitz, J; Büchler, M W

2010-04-01

The structural organization of research facilities within a surgical university center should aim at strengthening the department's research output and likewise provide opportunities for the scientific education of academic surgeons. We suggest a model in which several independent research groups within a surgical department engage in research projects covering various aspects of surgically relevant basic, translational or clinical research. In order to enhance the translational aspects of surgical research, a permanent link needs to be established between the department's scientific research projects and its chief interests in clinical patient care. Importantly, a focus needs to be placed on obtaining evidence-based data to judge the efficacy of novel diagnostic and treatment concepts. Integration of modern technologies from the fields of physics, computer science and molecular medicine into surgical research necessitates cooperation with external research facilities, which can be strengthened by coordinated support programs offered by research funding institutions.

Opportunity Cost and the Intelligence of Economists: A Comment

ERIC Educational Resources Information Center

Arce, Daniel G.

2016-01-01

In "Opportunity Cost: A Reexamination," Professor Parkin contrasts forgone physical quantities with forgone values as measures of the opportunity cost of basic economic decisions. The impetus for his study stems from an experiment conducted by Ferraro and Taylor (2005), in which professional economists could not reach a consensus over…

Lessons Learned from Accelerating Opportunity. Lessons Learned Series

ERIC Educational Resources Information Center

Wilson, Randall

2015-01-01

The Accelerating Opportunity initiative helps our nation's lowest-skilled adults earn college credentials and enter higher-wage jobs faster by combining the Adult Basic Education and career and technical training they need into one integrated curriculum. Based on four years of designing and managing Accelerating Opportunity, Jobs for the Future…

34 CFR 200.31 - Opportunity to review school-level data.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Opportunity to review school-level data. 200.31 Section... Improving Basic Programs Operated by Local Educational Agencies Lea and School Improvement § 200.31 Opportunity to review school-level data. (a) Before identifying a school for school improvement, corrective...

34 CFR 200.31 - Opportunity to review school-level data.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false Opportunity to review school-level data. 200.31 Section... Improving Basic Programs Operated by Local Educational Agencies Lea and School Improvement § 200.31 Opportunity to review school-level data. (a) Before identifying a school for school improvement, corrective...

Garrison Institute on Aging: A New Hope for Elderly Individuals and Patients with Alzheimer’s Disease

PubMed Central

Reddy, P. Hemachandra; Blackmon, Joan; Molinar-Lopez, Veronica; Ament, Clay; Manczak, Maria; Kandimalla, Ramesh; Yin, Xianglin; Pandey, Akhilesh; Kuruva, Chandra Sekhar; Wang, Rui; Fry, David; Osborn, Carrah; Stonum, Kathleen; Quesada, Kandi; Gonzales, Ruben; Boles, Annette

2016-01-01

The Garrison Institute on Aging (GIA) is an established institute within Texas Tech University Health Sciences Center, whose mission is to promote healthy aging through cutting-edge research on Alzheimer’s disease (AD) and other diseases of aging through innovative educational opportunities for students, clinicians, researchers, health care professionals, and the public. The GIA has multiple programs, including both research and education on healthy aging and AD, community outreach, caregiving, the Retired Senior Volunteer Program, Healthy Lubbock, the GIA Brain Bank, healthy aging seminars, research seminars, and collaborations and scholarships. The GIA programs connect basic and clinical researchers and health care professionals, and provide a unique environment to help our growing elderly population and patients with AD and their families. PMID:26402018

Donor Financing of Basic Education: Opportunities and Constraints

ERIC Educational Resources Information Center

Steer, Liesbet; Wathne, Cecilie

2010-01-01

Much progress has been made in improving access to basic education in recent years, but international support has been less than promised and the "funding gap" to achieve universal primary education remains stubbornly present. This article identifies six interrelated factors that constrain such donor financing. Prioritization of basic education,…

Profiles of 1975-76 Supplemental Basic Grant Applicants.

ERIC Educational Resources Information Center

Walters, Pamela Barnhouse

The nature and extent of misreporting by applicants for the Basic Educational Opportunity Grant program was investigated. Types of potential program abuse were assessed, along with the accuracy of income estimates that students make on Supplemental Basic Grant applications, which are the basis for determining a student's eligibility. Attention was…

[Environmental Hazards Assessment Program annual report, June 1992--June 1993]. Summer undergraduate research program: Environmental studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

McMillan, J.

1993-12-01

The purpose of the summer undergraduate internship program for research in environmental studies is to provide an opportunity for well-qualified students to undertake an original research project as an apprentice to an active research scientist in basic environmental research. Ten students from throughout the midwestern and eastern areas of the country were accepted into the program. These students selected projects in the areas of marine sciences, biostatistics and epidemiology, and toxicology. The research experience for all these students and their mentors was very positive. The seminars were well attended and the students showed their interest in the presentations and environmentalmore » sciences as a whole by presenting the speakers with thoughtful and intuitive questions. This report contains the research project written presentations prepared by the student interns.« less

New opportunities at the frontiers of spintronics

DOE PAGES

Hoffmann, Axel; Bader, Sam D.

2015-10-05

The field of spintronics, or magnetic electronics, is maturing and giving rise to new subfields. These new directions involve the study of collective spin excitations and couplings of the spin system to additional degrees of freedom of a material, as well as metastable phenomena due to perturbations that drive the system far from equilibrium. The interactions lead to possibilities for future applications within the realm of energy-efficient information technologies. Examples discussed herein include research opportunities associated with (i) various spin-orbit couplings, such as spin Hall effects, (ii) couplings to the thermal bath of a system, such as in spin Seebeckmore » effects, (iii) spin-spin couplings, such as via induced and interacting magnon excitations, and (iv) spin-photon couplings, such as in ultra-fast magnetization switching due to coherent photon pulses. These four basic frontier areas of research are giving rise to new applied disciplines known as spin-orbitronics, spin-caloritronics, magnonics, and spin-photonics, respectively. These topics are highlighted in order to stimulate interest in the new directions that spintronics research is taking, and to identify open issues to pursue.« less

Work-based Project Overcomes Basic Skills Stigma.

ERIC Educational Resources Information Center

Wallis, Emma

2002-01-01

A project to provide steel workers in North Wales with guidance about learning opportunities and to promote lifelong learning in the workplace focused on the development of basic information technology skills. (JOW)

Competition Overview Presentation: The basics on competing for EPA assistance programs

EPA Pesticide Factsheets

The basics on competing for EPA assistance programs. Finding EPA Competitive Opportunities and contact the Officer of Grants and Debarment competition staff should you have any additional questions or concerns.

Research in image management and access

NASA Technical Reports Server (NTRS)

Vondran, Raymond F.; Barron, Billy J.

1993-01-01

Presently, the problem of over-all library system design has been compounded by the accretion of both function and structure to a basic framework of requirements. While more device power has led to increased functionality, opportunities for reducing system complexity at the user interface level have not always been pursued with equal zeal. The purpose of this book is therefore to set forth and examine these opportunities, within the general framework of human factors research in man-machine interfaces. Human factors may be viewed as a series of trade-off decisions among four polarized objectives: machine resources and user specifications; functionality and user requirements. In the past, a limiting factor was the availability of systems. However, in the last two years, over one hundred libraries supported by many different software configurations have been added to the Internet. This document includes a statistical analysis of human responses to five Internet library systems by key features, development of the ideal online catalog system, and ideal online catalog systems for libraries and information centers.

Problems encountered by BA Cur graduates and recommendations for enhancing learner support.

PubMed

Ehlers, V

2000-12-01

Distance education is becoming ever more important in providing continuing post basic, and especially postgraduate, education to practising professional persons, including nurses. As more and more institutions in the Republic of South Africa offer distance education courses to nurses, it is essential to take note of the positive and negative experiences of successful graduates of these programmes, in order to enhance the learning opportunities, and the success rate of nurses pursuing such distance education courses. A brief historical overview is provided about the University of South Africa (Unisa) and about the Department of Advanced Nursing Sciences at this distance education university. This background information should assist the reader in contextualising the research findings. Questionnaires were posted to all Unisa's 1998 BA Cur graduates. The research report focuses on the 1998 BA Cur (nursing) graduates' biographic data, their experiences of pursuing distance education post basic nursing courses, their positive and negative perceptions of these experiences and their recommendations for enhancing other students' success.

Between Industry and Academia: A Physicist's Experiences at The Aerospace Corporation

NASA Astrophysics Data System (ADS)

Camparo, James

2005-03-01

The Aerospace Corporation is a nonprofit company whose purposes are exclusively scientific: to provide research, development, and advisory services for space programs that serve the national interest, primarily the Air Force's Space and Missile Systems Center and the National Reconnaissance Office. The corporation's laboratory has a staff of about 150 scientists who conduct research in fields ranging from Space Sciences to Material Sciences and from Analytical Chemistry to Atomic Physics. As a consequence, Aerospace stands midway between an industrial research laboratory, focused on product development, and academic/national laboratories focused on basic science. Drawing from Dr. Camparo's personal experiences, the presentation will discuss advantages and disadvantages of a career at Aerospace, including the role of publishing in peer-reviewed journals and the impact of work on family life. Additionally, the presentation will consider the balance between basic physics, applied physics, and engineering in the work at Aerospace. Since joining Aerospace in 1981, Dr. Camparo has worked as an atomic physicist specializing in the area of atomic clocks, and has had the opportunity to experiment and publish on a broad range of research topics including: the stochastic-field/atom interaction, radiation effects on semiconductor materials, and stellar scintillation.

Cooperative Education Is a Superior Strategy for Using Basic Learning Processes.

ERIC Educational Resources Information Center

Reed, V. Gerald

Cooperative education is a learning strategy that fits very well with basic laws of learning. In fact, several basic important learning processes are far better adapted to the cooperative education strategy than to methods that lean entirely on classroom instruction. For instance, cooperative education affords more opportunities for reinforcement,…

[Private medical education in Germany].

PubMed

Schwörer, Beatrix; Wissing, Frank

2018-02-01

Through the years, a range of privately funded medical training opportunities has been established in Germany. Only a few of them operate along the German Medical Licensure Act and thus underlie quality assurance regulations in Germany. Most of the courses are a result of German hospitals cooperating with universities from other EU countries. The content of the courses and the examinations underlie the regulations of the university's home country. This article aims to give an overview of the private medical training opportunities offered in Germany and to show differences compared to state funded German medical schools. The authors discuss the opportunities of private medical training as well as its challenges and risks. Basic principles concerning finances and quality assurance of national and international private medical training are provided. Regardless of their mode of financing, the superior goal of the training, according to the German Medical Licensure Act, should always be to enable young doctors to pursue further professional training, so that they can maintain the best possible quality in patient care, research, and medical education.

First-year engineering students' use of their mathematics textbook - opportunities and constraints

NASA Astrophysics Data System (ADS)

Randahl, Mira

2012-09-01

The role of the mathematics textbook at tertiary level has received limited exposure in previous research although it is likely that students work individually and that some of this work depends on the use of the textbook. The aim of this study was to investigate the process of approaching the textbook from epistemological, cognitive, and didactical perspectives. The focus was on identifying and discussing the opportunities and constraints in the process. The study was an explorative case study and the participants were first-year engineering students taking a basic calculus course. The data were collected through questionnaires, observations, and interviews. Results showed that the textbook was used to a very low degree and mainly perceived as a source of tasks. Different opportunities and constraints are pointed out and some didactical implications are suggested. The results and discussion indicate that a need for greater awareness about the use of mathematical textbooks in meaningful ways at tertiary level.

The career goals of nurses in some health care settings in Gauteng.

PubMed

Jooste, K

2005-08-01

In nursing, purposeful career planning is essential if nurse practitioners want to make the right decisions about their work in order to strive towards and accomplish a meaningful quality of working life. Nurses should identify their career goals to be able to investigate their different career opportunities in their field of interest and direct their work according to a work strategy for years ahead. The purpose of this study was to explore and describe the career goals of post-basic nursing students with the aim of describing management strategies to guide the future career of post-basic nursing students in climbing the career ladder effectively and obtaining their set career goals. An explorative, descriptive, qualitative design was selected where the researcher worked inductively to explore and describe the needs (goals) and future planned actions of the participants regarding their career management as viewed for a period of five years. The researcher purposively and conveniently identified the sample as all the post-basic nursing students, namely 250 students, who were registered for the first, second and third year of nursing management courses in that period at a South African residential university. Two structured, open questions were developed. Each participant received the questions in writing and was asked to answer them. The QSR NUD*IST program was used for the qualitative management (categorization) of data. The results of the research questions related to five categories, namely becoming empowered, being promoted, being educated and professionally developed, partaking in research and taking up new projects.

Health- and Disease-Related Biomarkers in Aging Research

PubMed Central

Thompson, Hilaire J.; Voss, Joachim G.

2011-01-01

This article focuses on a synthesis of knowledge about healthy aging research in human beings and then synthesized nurse-led research in gerontology and geriatrics that use biomarkers. Healthy aging research has attracted considerable attention in the biomedical and basic sciences within the context of four major areas: (a) genetic variations as an expression of successful or unsuccessful aging; (b) caloric restriction as an intervention to slow the progression of aging; (c) immunological aging; (d) neurobiology of the aging brain. A systematic review of the literature was performed to identify nurse-led geriatric-related biomarker research. Nurse researchers who have chosen to integrate biomarkers as part of their research studies have been working in six focal areas, which are reviewed: health promotion within risk populations, cancer, vascular disease, Alzheimer’s disease, caregiving, and complementary therapies. The article provides a discussion of contributions to date, identifying existing gaps and future research opportunities. PMID:20077975

Organisational aspects and benchmarking of e-learning initiatives: a case study with South African community health workers.

PubMed

Reisach, Ulrike; Weilemann, Mitja

2016-06-01

South Africa desperately needs a comprehensive approach to fight HIV/AIDS. Education is crucial to reach this goal and Internet and e-learning could offer huge opportunities to broaden and deepen the knowledge basis. But due to the huge societal and digital divide between rich and poor areas, e-learning is difficult to realize in the townships. Community health workers often act as mediators and coaches for people seeking medical and personal help. They could give good advice regarding hygiene, nutrition, protection of family members in case of HIV/AIDS and finding legal ways to earn one's living if they were trained to do so. Therefore they need to have a broader general knowledge. Since learning opportunities in the townships are scarce, a system for e-learning has to be created in order to overcome the lack of experience with computers or the Internet and to enable them to implement a network of expertise. The article describes how the best international resources on basic medical knowledge, HIV/AIDS as well as on basic economic and entrepreneurial skills were benchmarked to be integrated into an e-learning system. After tests with community health workers, researchers developed recommendations on building a self-sustaining system for learning, including a network of expertise and best practice sharing. The article explains the opportunities and challenges for community health workers, which could provide information for other parts of the world with similar preconditions of rural poverty. © The Author(s) 2015.

An Attempt to Improve Students' Presentation Skills via Course of Graduation Research and its Educational Effects

NASA Astrophysics Data System (ADS)

Yamaguchi, Kenji; Ohtuka, Sigeru; Morita, Shinichi; Matsumoto, Itaru; Yakabe, Masaki; Hayamizu, Yasutaka; Ohtuka, Kouichi

The importance of presentation skills rapidly increases in engineering education in Japan. The authors have applied various teaching-method of presentation skills to the course of graduation research for the fifth-grade students of the mechanical engineering program in Yonago National College of Technology. The lectures including teachers' demonstration and basic skills in presentation have resulted in improvement of students' skills. The meeting for announcing the results of graduation research has been opened to the public in cooperation with the Yonago Chamber of Commerce and Industry to give the students incentives to graduation research as well as presentation. The students have mutually evaluated their presentation to get good opportunities for even self-evaluation. This paper discusses the effects and problems of our educational practice.

Department of Energy - Office of Science Early Career Research Program

NASA Astrophysics Data System (ADS)

Horwitz, James

The Department of Energy (DOE) Office of Science Early Career Program began in FY 2010. The program objectives are to support the development of individual research programs of outstanding scientists early in their careers and to stimulate research careers in the disciplines supported by the DOE Office of Science. Both university and DOE national laboratory early career scientists are eligible. Applicants must be within 10 years of receiving their PhD. For universities, the PI must be an untenured Assistant Professor or Associate Professor on the tenure track. DOE laboratory applicants must be full time, non-postdoctoral employee. University awards are at least 150,000 per year for 5 years for summer salary and expenses. DOE laboratory awards are at least 500,000 per year for 5 years for full annual salary and expenses. The Program is managed by the Office of the Deputy Director for Science Programs and supports research in the following Offices: Advanced Scientific and Computing Research, Biological and Environmental Research, Basic Energy Sciences, Fusion Energy Sciences, High Energy Physics, and Nuclear Physics. A new Funding Opportunity Announcement is issued each year with detailed description on the topical areas encouraged for early career proposals. Preproposals are required. This talk will introduce the DOE Office of Science Early Career Research program and describe opportunities for research relevant to the condensed matter physics community. http://science.energy.gov/early-career/

The New Commercial Suborbital Vehicles: An Opportunity for Scientific and Microgravity Research

NASA Astrophysics Data System (ADS)

Moro-Aguilar, Rafael

2014-11-01

As of 2013, a number of companies had announced their intention to start flying suborbital vehicles, capable of transporting people to high altitudes out of any airport or launch site, on a commercial and regular basis. According to several studies, a market for suborbital "space tourism" exists. Another very promising application of suborbital flight is scientific research. The present paper provides an overview of the potential of commercial suborbital flight for science, including microgravity research. Suborbital flight provides a much-needed intermediate-duration opportunity between research performed in Earth orbit and more affordable but shorter duration alternatives, such as drop towers and zero-g parabolic flights. Moreover, suborbital flight will be less expensive and more frequent than both orbital flight and sounding rockets, and it has the capability to fly into sub-orbit the researcher together with the payload, and thus enable on-site interaction with the experiment. In the United States, both the National Aeronautics and Space Administration (NASA) and a number of private institutions have already shown interest in conducting scientific experiments, particularly microgravity research, aboard these new platforms. Researchers who intend to participate in future suborbital flights as payload specialists will need training, given the physical challenges posed by the flight. Finally, suborbital researchers may also want to have a basic knowledge of the legal status that will apply to them as passengers of such flights.

Female Sex and Gender in Lung/Sleep Health and Disease: Increased Understanding of Basic Biological, Pathophysiological and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease.

PubMed

Han, MeiLan K; Arteaga-Solis, Emilio; Blenis, John; Bourjeily, Ghada; Clegg, Deborah J; DeMeo, Dawn; Duffy, Jeanne; Gaston, Ben; Heller, Nicola M; Hemnes, Anna; Henske, Elizabeth Petri; Jain, Raksha; Lahm, Tim; Lancaster, Lisa H; Lee, Joyce; Legato, Marianne J; McKee, Sherry; Mehra, Reena; Morris, Alison; Prakash, Y S; Stampfli, Martin R; Gopal-Srivastava, Rashmi; Laposky, Aaron D; Punturieri, Antonello; Reineck, Lora; Tigno, Xenia; Clayton, Janine

2018-05-10

Female sex/gender is an under-characterized variable in studies related to lung development and disease. Notwithstanding, many aspects of lung and sleep biology and pathobiology are impacted by female sex and female reproductive transitions. These may manifest as differential gene expression or peculiar organ development. Some conditions are more prevalent in women, such as asthma and insomnia, or in the case of LAM, are seen almost exclusively in women. In other diseases, presentation differs such as the higher frequency of exacerbations experienced by women with COPD or greater cardiac morbidity among women with sleep disordered breathing. Recent advances in -omics and behavioral science provide an opportunity to specifically address sex-based differences and explore research needs and opportunities that will elucidate biochemical pathways, thus enabling more targeted/personalized therapies. To explore the status of and opportunities for research in this area, the National Heart, Lung, and Blood Institute (NHLBI), in partnership with the National Institutes of Health (NIH) Office of Research on Women's Health (ORWH) and the Office of Rare Diseases Research (ORDR), convened a workshop of investigators in Bethesda, (MD) on September 18-19, 2017. At the workshop the participants reviewed the current understanding of the biological, behavioral, and clinical implications of female sex and gender on lung and sleep health and disease, and formulated recommendations that address research gaps, with a view of achieving better health outcomes through more precise management of female patients with non-neoplastic lung disease were proposed. This report summarizes those discussions.

Rethinking the Way We Do Research: The Benefits of Community-Engaged, Citizen Science Approaches and Nontraditional Collaborators.

PubMed

Dick, Danielle M

2017-11-01

There is tremendous opportunity for basic scientists to enhance the impact of our research by engaging more deeply with nontraditional partners and expanding the way we think about interdisciplinary research teams. These efforts can include more deeply engaging our participants, and the broader public, in our research; working with individuals from other fields to take a more active role in the dissemination and translation of our research; and working with collaborators from the arts and communication sciences to make our research more engaging and understandable. In this review, I provide an overview of our efforts along these lines in a project called Spit for Science (https://spit4science.vcu.edu/). This project draws from concepts central to community-engaged participatory research and citizen science. Although conducting research in this way involves a considerable time commitment, it has many potential benefits, including raising awareness about our research areas and findings; creating a public that is more connected to and aware of the importance of research, which can have potential implications for funding for science; creating new job opportunities for students; and increasing participation rates in our studies. By thinking creatively about how we conduct our research, and more broadly engaging diverse groups of individuals in the research process, we have the potential to significantly increase the reach and impact of our science. Copyright © 2017 by the Research Society on Alcoholism.

FY2010 Supplemental for Wars, Disaster Assistance, Haiti Relief, and Other Programs

DTIC Science & Technology

2010-06-30

development; • Private sector development: $60.4 million; and • Economic opportunity : $8.6 million to expand credit union services, including Islamic... opportunities outside of Port-au- Prince. The Haitian government and donors agree that the current crisis provides an opportunity to correct what had become...report directs U.S. agencies to reestablish and strengthen basic and secondary educational opportunities , and to ensure that displaced children in

Commercial biotechnology processing thermal control for transfer payloads to/from the International Space Station

NASA Astrophysics Data System (ADS)

Jennings, William M.; Vellinger, John C.; Deuser, Mark S.

2000-01-01

Biotechnology is undergoing a period of rapid and sustained growth, a trend which is expected to continue as the general population ages and as new medical treatments and products are conceived. As pharmaceutical and biomedical companies continue to search for improved methods of production and, for answers to basic research questions, they will seek out new avenues of research. Space processing on the International Space Station (ISS) offers such an opportunity! Space is rapidly becoming an industrial laboratory for biotechnology research and processing. Space bioprocessing offers exciting possibilities for developing new pharmaceuticals and medical treatments which can be used to benefit mankind on Earth. It also represents a new economic frontier for the private sector. .

PREFACE: 2nd International Conference and Young Scientist School ''Magnetic resonance imaging in biomedical research''

NASA Astrophysics Data System (ADS)

Naumova, A. V.; Khodanovich, M. Y.; Yarnykh, V. L.

2016-02-01

The Second International Conference and Young Scientist School ''Magnetic resonance imaging in biomedical research'' was held on the campus of the National Research Tomsk State University (Tomsk, Russia) on September 7-9, 2015. The conference was focused on magnetic resonance imaging (MRI) applications for biomedical research. The main goal was to bring together basic scientists, clinical researchers and developers of new MRI techniques to bridge the gap between clinical/research needs and advanced technological solutions. The conference fostered research and development in basic and clinical MR science and its application to health care. It also had an educational purpose to promote understanding of cutting-edge MR developments. The conference provided an opportunity for researchers and clinicians to present their recent theoretical developments, practical applications, and to discuss unsolved problems. The program of the conference was divided into three main topics. First day of the conference was devoted to educational lectures on the fundamentals of MRI physics and image acquisition/reconstruction techniques, including recent developments in quantitative MRI. The second day was focused on developments and applications of new contrast agents. Multinuclear and spectroscopic acquisitions as well as functional MRI were presented during the third day of the conference. We would like to highlight the main developments presented at the conference and introduce the prominent speakers. The keynote speaker of the conference Dr. Vasily Yarnykh (University of Washington, Seattle, USA) presented a recently developed MRI method, macromolecular proton fraction (MPF) mapping, as a unique tool for modifying image contrast and a unique tool for quantification of the myelin content in neural tissues. Professor Yury Pirogov (Lomonosov Moscow State University) described development of new fluorocarbon compounds and applications for biomedicine. Drs. Julia Velikina and Alexey Samsonov (University of Wisconsin-Madison, USA) demonstrated new image reconstruction methods for accelerated quantitative parameter mapping and magnetic resonance angiography. Finally, we would like to thank the scientific committee, the local organizing committee and the National Research Tomsk State University for giving an opportunity to share scientific ideas and new developments at the conference and the Russian Science Foundation (project № 14-45-00040) for financial support.

[Cut a long story too short: Challenges in clinical research].

PubMed

Stallmach, A; Hagel, S; Bruns, T; Bauer, M

2012-03-01

Clinical research reflects a mandatory prerequisite to translate basic research into clinical practice. While a lack of available qualified doctors to fill positions in hospitals as well as in the ambulant sector has prompted political decisions to counteract, Germany has witnessed an insidious deterioration of clinical research over time and compared to other industrialized countries. Measures to prevent an increasing loss of academic profile have to tackle all aspects from undergraduate to postgraduate training to attract highly skilled doctors in sustainable structures to reflourish academic medicine. Cornerstones to achieve these goals involve establishing of structured graduate programs, acknowledgment of time spend in clinical research in residency programs, extra occupational opportunities to achieve dual qualification (e. g. Master programs in clinical research) as well as independent positions with inherent carrier perspectives in academic medicine for doctors interested in clinical and translational research. © Georg Thieme Verlag KG Stuttgart · New York.

A multifaceted program to encourage medical students' research.

PubMed

Zier, K; Stagnaro-Green, A

2001-07-01

Clinician-scientists are important members of a research community that has more opportunities than ever before to solve problems important to patients. Nevertheless, the number of physicians applying for and receiving grants from the National Institutes of Health (NIH) has dropped. Introducing medical students to research and relevant support mechanisms early in their education may help to reverse this trend. In 1995, the Mount Sinai School of Medicine created its Office of Student Research Opportunities (OSRO) to stimulate students to engage in research. It also appointed a new dean to direct the OSRO; the person who filled this new position was a senior faculty member involved in patient-oriented research. The OSRO advises students, identifies faculty who want to mentor students, sponsors the Distinction in Research program, organizes an annual research day, helps fund summer and full-time research, and has created an endowment to support student travel to national meetings. Between 1997 and 2000 the number of students who participated in the research day increased from 18 to 74, and the number of publications by the graduating classes increased from 34 to 58 between 1997 and 1999. Participants have presented both basic and clinical projects. The authors' experience has shown that medical students can be motivated to carry out research with appropriate encouragement from the administration and the faculty, something that may help to reverse a troubling national trend. Based upon these early successes, Mount Sinai is developing a novel five-year program to provide medical students with research training.

One Size Will Never Fit All: Clinical and Translational Research Gaps in Pediatric Transfusion Medicine

PubMed Central

Josephson, Cassandra D.; Mondoro, Traci Heath; Ambruso, Daniel R.; Sanchez, Rosa; Sloan, Steven R.; Luban, Naomi L.C.; Widness, John A.

2015-01-01

There is concern at the National Heart, Lung, and Blood Institute (NHLBI) and among transfusion medicine specialists regarding the small number of investigators and studies in the field of pediatric transfusion medicine (PTM). Accordingly, the objective of this article is to provide a snapshot of the clinical and translational PTM research considered to be of high priority by pediatricians, neonatologists, and transfusion medicine specialists. Included is a targeted review of three research areas of importance: 1) transfusion strategies, 2) short- and long-term clinical consequences, and 3) transfusion-transmitted infectious diseases. The recommendations by PTM and transfusion medicine specialists represent opportunities and innovative strategies to execute translational research, observational studies, and clinical trials of high relevance to PTM. With the explosion of new biomedical knowledge and increasingly sophisticated methodologies over the past decade, this is an exciting time to consider transfusion medicine as a paradigm for addressing questions related to fields such as cell biology, immunology, neurodevelopment, outcomes research and many others. Increased awareness of PTM as an, important, fertile field and the promotion of accompanying opportunities will help establish PTM as a viable career option and advance basic and clinical investigation to improve the health and wellbeing of children. PMID:25119336

Cancer Treatment–Related Cardiotoxicity: Current State of Knowledge and Future Research Priorities

PubMed Central

Adhikari, Bishow; Brell, Joanna; Davis, Myrtle; Desvigne-Nickens, Patrice; Freedman, Andrew; Minasian, Lori; Force, Thomas; Remick, Scot C.

2014-01-01

Cardiotoxicity resulting from direct myocyte damage has been a known complication of cancer treatment for decades. More recently, the emergence of hypertension as a clinically significant side effect of several new agents has been recognized as adversely affecting cancer treatment outcomes. With cancer patients living longer, in part because of treatment advances, these adverse events have become increasingly important to address. However, little is known about the cardiovascular pathogenic mechanisms associated with cancer treatment and even less about how to optimally prevent and manage short- and long-term cardiovascular complications, leading to improved patient safety and clinical outcomes. To identify research priorities, allocate resources, and establish infrastructure required to address cardiotoxicity associated with cancer treatment, the National Cancer Institute (NCI) and National Heart, Lung and Blood Institute (NHLBI) sponsored a two-day workshop, “Cancer treatment–related cardiotoxicity: Understanding the current state of knowledge and future research priorities,” in March 2013 in Bethesda, MD. Participants included leading oncology and cardiology researchers and health professionals, patient advocates and industry representatives, with expertise ranging from basic to clinical science. Attendees were charged with identifying research opportunities to advance the understanding of cancer treatment–related cardiotoxicity across basic and clinical science. This commentary highlights the key discussion points and overarching recommendations from that workshop. PMID:25210198

National policies for technical change: Where are the increasing returns to economic research?

PubMed Central

Pavitt, Keith

1996-01-01

Improvements over the past 30 years in statistical data, analysis, and related theory have strengthened the basis for science and technology policy by confirming the importance of technical change in national economic performance. But two important features of scientific and technological activities in the Organization for Economic Cooperation and Development countries are still not addressed adequately in mainstream economics: (i) the justification of public funding for basic research and (ii) persistent international differences in investment in research and development and related activities. In addition, one major gap is now emerging in our systems of empirical measurement—the development of software technology, especially in the service sector. There are therefore dangers of diminishing returns to the usefulness of economic research, which continues to rely completely on established theory and established statistical sources. Alternative propositions that deserve serious consideration are: (i) the economic usefulness of basic research is in the provision of (mainly tacit) skills rather than codified and applicable information; (ii) in developing and exploiting technological opportunities, institutional competencies are just as important as the incentive structures that they face; and (iii) software technology developed in traditional service sectors may now be a more important locus of technical change than software technology developed in “high-tech” manufacturing. PMID:8917481

Using a Thyroid Case Study and Error Plausibility to Introduce Basic Lab Skills

ERIC Educational Resources Information Center

Browning, Samantha; Urschler, Margaret; Meidl, Katherine; Peculis, Brenda; Milanick, Mark

2017-01-01

We describe a 3-hour session that provides students with the opportunity to review basic lab concepts and important techniques using real life scenarios. We began with two separate student-engaged discussions to remind/reinforce some basic concepts in physiology and review calculations with respect to chemical compounds. This was followed by…

The Prevalence of Anxiety and Pro-Social Behaviors in Child-Centered and Basic Skills Preschool Classrooms.

ERIC Educational Resources Information Center

Reio, Thomas G., Jr.; Maciolek, C. Lynn; Weiss, Erin M.

Although there is considerable evidence that kindergartners in child-centered programs have more opportunities to increase prosocial behavior and are more internally motivated than children in basic skills programs, the efficacy of child-centered versus basic skills programs with regard to prosocial behavior has not been examined among preschool…

Revisiting the destination ranking procedure in development of an Intervening Opportunities Model for public transit trip distribution

NASA Astrophysics Data System (ADS)

Nazem, Mohsen; Trépanier, Martin; Morency, Catherine

2015-01-01

An Enhanced Intervening Opportunities Model (EIOM) is developed for Public Transit (PT). This is a distribution supply dependent model, with single constraints on trip production for work trips during morning peak hours (6:00 a.m.-9:00 a.m.) within the Island of Montreal, Canada. Different data sets, including the 2008 Origin-Destination (OD) survey of the Greater Montreal Area, the 2006 Census of Canada, GTFS network data, along with the geographical data of the study area, are used. EIOM is a nonlinear model composed of socio-demographics, PT supply data and work location attributes. An enhanced destination ranking procedure is used to calculate the number of spatially cumulative opportunities, the basic variable of EIOM. For comparison, a Basic Intervening Opportunities Model (BIOM) is developed by using the basic destination ranking procedure. The main difference between EIOM and BIOM is in the destination ranking procedure: EIOM considers the maximization of a utility function composed of PT Level Of Service and number of opportunities at the destination, along with the OD trip duration, whereas BIOM is based on a destination ranking derived only from OD trip durations. Analysis confirmed that EIOM is more accurate than BIOM. This study presents a new tool for PT analysts, planners and policy makers to study the potential changes in PT trip patterns due to changes in socio-demographic characteristics, PT supply, and other factors. Also it opens new opportunities for the development of more accurate PT demand models with new emergent data such as smart card validations.

Glenn's Strategic Partnerships With HBCUs and OMUs

NASA Technical Reports Server (NTRS)

Kankam, M. David

2003-01-01

NASA senior management has identified the need to develop a strategy for increased contracting with the historically black colleges and universities (HBCUs) and other minority universities (OMUs). The benefits to the institutions, by partnering with NASA, include developing their industrial base via NASA-industry partnerships, strong competitive advantage in technology-based research opportunities, and improved research capabilities. NASA gains increased contributed value to the Agency missions and programs as well as potential future recruits from technology-trained students who also constitute a pool for the nation s workforce. This report documents synergistic links between Glenn Research Center research and technology programs and faculty expertise at HBCUs and OMUs. The links are derived, based on Glenn technologies in the various directorates, program offices, and project offices. Such links readily identify universities with faculty members who are knowledgeable or have backgrounds in the listed technologies for possible collaboration. Recommendations are made to use the links as opportunities for Glenn and NASA, as well as industry collaborators, to cultivate stronger partnerships with the universities. It is concluded that Glenn and its partners and collaborators can expect to mutually benefit from leveraging NASA s cutting-edge and challenging research and technologies; industry's high technology development, research and development facilities, system design capabilities and market awareness; and academia s expertise in basic research and relatively low overhead cost. Reduced cost, accelerated technology development, technology transfer, and infrastructure development constitute some of the derived benefits.

A new vision for the study of benign prostate disease: the NIDDK Prostate Research Strategic Plan.

PubMed

Mullins, Chris; Kaplan, Steven A

2009-03-01

The American population continues to enjoy a steady increase in life expectancy. A major goal for this population is to maintain and improve quality of life as it ages. For men a major source of age related health burden is benign disorders of the prostate which, despite much research, remain poorly defined and require greater advancement in prevention and treatment. Thus, there is a substantial need to develop a long-range vision to focus and promote efforts to better understand and manage benign prostate disease. In response the National Institute of Diabetes and Digestive and Kidney Diseases convened a panel of key opinion leaders including basic researchers, translational scientists, epidemiologists, and clinicians and clinical researchers to develop a comprehensive strategic plan to advance research in benign prostate disease. The overall mission statement of this effort is "To discuss, evaluate, and propose research needs and a long-range research agenda (ie a strategic plan) for NIDDK grant portfolios related to research into benign prostate disease." Implementation and practical application of this strategic plan will require a partnership of the scientific community, the Federal Government, and other public and private organizations and institutions. This focused group of research and thought leaders identified 4 major areas of key significance for future investigation: basic science, epidemiology/population based studies, translational opportunities and clinical sciences. Great opportunities are identified within these 4 areas to develop new insights, and translate findings for benign prostate diseases and related syndromes between the research laboratory and the clinical setting. The product of these efforts, the National Institute of Diabetes and Digestive and Kidney Diseases Prostate Research Strategic Plan, represents a blueprint that researchers and Federal Government can use to review where the field has been, define where the field is and, most importantly, identify where and how future research efforts should be directed. To accomplish this goal many priorities must be addressed, including the need to create more effective lines of communication among scientific disciplines to improve translation of research findings and ultimately advance patient treatment. The overall goals and missions of the National Institute of Diabetes and Digestive and Kidney Diseases Prostate Research Strategic Plan, along with key scientific recommendations and priorities for the major areas of focus, are summarized.

Opportunity for academic research in a low-gravity environment - Crystal growth

NASA Technical Reports Server (NTRS)

Matthiesen, D. H.; Wargo, M. J.; Witt, A. F.

1986-01-01

The history of basic and applied research on crystal growth (CG), especially of semiconductor materials, is reviewed, stressing the dominance (at least in the U.S.) of industrial R&D projects over academic programs and the need for more extensive fundamental investigations. The NASA microgravity research program and the recommendations of the University Space Research Association are examined as they affect the availability of space facilities for academic CG research. Also included is a report on ground experiments on the effectiveness of magnetic fields in controlling vertical Bridgman CG and melt stability, using the apparatus employed in the Apollo-Soyuz experiments (Witt et al., 1978); the results are presented in graphs and briefly characterized. The role of NASA's microgravity CG program in stimulating academic work on CG, the importance of convection effects, CG work on materials other than semiconductors, and NSF support of CG research are discussed in a comment by R. F. Sekerka.

[Precision medicine: new opportunities and challenges for molecular epidemiology].

PubMed

Song, Jing; Hu, Yonghua

2016-04-01

Since the completion of the Human Genome Project in 2003 and the announcement of the Precision Medicine Initiative by U.S. President Barack Obama in January 2015, human beings have initially completed the " three steps" of " genomics to biology, genomics to health as well as genomics to society". As a new inter-discipline, the emergence and development of precision medicine have relied on the support and promotion from biological science, basic medicine, clinical medicine, epidemiology, statistics, sociology and information science, etc. Meanwhile, molecular epidemiology is considered to be the core power to promote precision medical as a cross discipline of epidemiology and molecular biology. This article is based on the characteristics and research progress of medicine and molecular epidemiology respectively, focusing on the contribution and significance of molecular epidemiology to precision medicine, and exploring the possible opportunities and challenges in the future.

75 FR 39953 - Modification to the Basic Center Program Funding Opportunity Announcement

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-13

.... Announcement Type: Modification. Funding Opportunity Number: HHS-2010-ACF-ACYF-CY-0002. CFDA Number: 93.623... points. Margins less than \\1/2\\ inch: Deduction of 3 points. Font is not at least 12-point size or Times...

Towards large-scale, human-based, mesoscopic neurotechnologies.

PubMed

Chang, Edward F

2015-04-08

Direct human brain recordings have transformed the scope of neuroscience in the past decade. Progress has relied upon currently available neurophysiological approaches in the context of patients undergoing neurosurgical procedures for medical treatment. While this setting has provided precious opportunities for scientific research, it also has presented significant constraints on the development of new neurotechnologies. A major challenge now is how to achieve high-resolution spatiotemporal neural recordings at a large scale. By narrowing the gap between current approaches, new directions tailored to the mesoscopic (intermediate) scale of resolution may overcome the barriers towards safe and reliable human-based neurotechnology development, with major implications for advancing both basic research and clinical translation. Copyright © 2015 Elsevier Inc. All rights reserved.

Dyads and triads at 35,000 feet - Factors affecting group process and aircrew performance

NASA Technical Reports Server (NTRS)

Foushee, H. C.

1984-01-01

The task of flying a multipilot transport aircraft is a classic small-group performance situation where a number of social, organizational, and personality factors are relevant to important outcome variables such as safety. The aviation community is becoming increasingly aware of the importance of these factors but is hampered in its efforts to improve the system because of research psychology's problems in defining the nature of the group process. This article identifies some of the problem areas as well as methods used to address these issues. It is argued that high fidelity flight simulators provide an environment that offers unique opportunities for work meeting both basic and applied research criteria.

Dyads and triads at 35,000 feet: Factors affecting group process and aircrew performance

NASA Technical Reports Server (NTRS)

Foushee, H. Clayton

1987-01-01

The task of flying a multipilot transport aircraft is a classic small-group performance situation where a number of social, organizational, and personality factors are relevant to important outcome variables such as safety. The aviation community is becoming increasingly aware of the importance of these factors but is hampered in its efforts to improve the system because of research psychology's problems in defining the nature of the group process. This article identifies some of the problem areas as well as methods used to address these issues. It is argued that high fidelity flight simulators provide an environment that offers unique opportunities for work meeting both basic and applied research criteria.

Research opportunities in salt hydrates for thermal energy storage

NASA Astrophysics Data System (ADS)

Braunstein, J.

1983-11-01

The state of the art of salt hydrates as phase change materials for low temperature thermal energy storage is reviewed. Phase equilibria, nucleation behavior and melting kinetics of the commonly used hydrate are summarized. The development of efficient, reliable inexpensive systems based on phase change materials, especially salt hydrates for the storage (and retrieval) of thermal energy for residential heating is outlined. The use of phase change material thermal energy storage systems is not yet widespread. Additional basic research is needed in the areas of crystallization and melting kinetics, prediction of phase behavior in ternary systems, thermal diffusion in salt hydrate systems, and in the physical properties pertinent to nonequilibrium and equilibrium transformations in these systems.

Medical Physics Panel Discussion

NASA Astrophysics Data System (ADS)

Guèye, Paul; Avery, Steven; Baird, Richard; Soares, Christopher; Amols, Howard; Tripuraneni, Prabhakar; Majewski, Stan; Weisenberger, Drew

2006-03-01

The panel discussion will explore opportunities and vistas in medical physics research and practice, medical imaging, teaching medical physics to undergraduates, and medical physics curricula as a recruiting tool for physics departments. Panel members consist of representatives from NSBP (Paul Guèye and Steven Avery), NIH/NIBIB (Richard Baird), NIST (Christopher Soares), AAPM (Howard Amols), ASTRO (Prabhakar Tripuraneni), and Jefferson Lab (Stan Majewski and Drew Weisenberger). Medical Physicists are part of Departments of Radiation Oncology at hospitals and medical centers. The field of medical physics includes radiation therapy physics, medical diagnostic and imaging physics, nuclear medicine physics, and medical radiation safety. It also ranges from basic researcher (at college institutions, industries, and laboratories) to applications in clinical environments.

Reengineering Translational Science: The Time Is Right

PubMed Central

Collins, Francis S.

2011-01-01

Despite dramatic advances in the molecular pathogenesis of disease, translation of basic biomedical research into safe and effective clinical applications remains a slow, expensive, and failure-prone endeavor. To pursue opportunities for disruptive translational innovation, the U.S. National Institutes of Health (NIH) intends to establish a new entity, the National Center for Advancing Translational Sciences (NCATS). The mission of NCATS is to catalyze the generation of innovative methods and technologies that will enhance the development, testing, and implementation of diagnostics and therapeutics across a wide range of diseases and conditions. The new center’s activities will complement, and not compete with, translational research being carried out at NIH and elsewhere in the public and private sectors. PMID:21734173

Implementing Communication Studies into General Education: The Basic Course as General Education (Or, How We Made It Work for Us).

ERIC Educational Resources Information Center

Buckrop, Jacquelyn J.

At Ball State University in Indiana, the basic course (COMM 210) focuses communication concepts and skills with the goals of helping students understand basic communication principles, providing them with the opportunity to improve their communication skills, and enhancing their awareness of communication's role in culture. Special emphasis is…

SSERVI Analog Regolith Simulant Testbed Facility

NASA Astrophysics Data System (ADS)

Minafra, Joseph; Schmidt, Gregory; Bailey, Brad; Gibbs, Kristina

2016-10-01

The Solar System Exploration Research Virtual Institute (SSERVI) at NASA's Ames Research Center in California's Silicon Valley was founded in 2013 to act as a virtual institute that provides interdisciplinary research centered on the goals of its supporting directorates: NASA Science Mission Directorate (SMD) and the Human Exploration & Operations Mission Directorate (HEOMD).Primary research goals of the Institute revolve around the integration of science and exploration to gain knowledge required for the future of human space exploration beyond low Earth orbit. SSERVI intends to leverage existing JSC1A regolith simulant resources into the creation of a regolith simulant testbed facility. The purpose of this testbed concept is to provide the planetary exploration community with a readily available capability to test hardware and conduct research in a large simulant environment.SSERVI's goals include supporting planetary researchers within NASA, other government agencies; private sector and hardware developers; competitors in focused prize design competitions; and academic sector researchers.SSERVI provides opportunities for research scientists and engineers to study the effects of regolith analog testbed research in the planetary exploration field. This capability is essential to help to understand the basic effects of continued long-term exposure to a simulated analog test environment.The current facility houses approximately eight tons of JSC-1A lunar regolith simulant in a test bin consisting of a 4 meter by 4 meter area, including dust mitigation and safety oversight.Facility hardware and environment testing scenarios could include, Lunar surface mobility, Dust exposure and mitigation, Regolith handling and excavation, Solar-like illumination, Lunar surface compaction profile, Lofted dust, Mechanical properties of lunar regolith, Surface features (i.e. grades and rocks)Numerous benefits vary from easy access to a controlled analog regolith simulant testbed, and planetary exploration activities at NASA Research Park, to academia and expanded commercial opportunities, as well as public outreach and education opportunities.

Biotechnology Facility: An ISS Microgravity Research Facility

NASA Technical Reports Server (NTRS)

Gonda, Steve R.; Tsao, Yow-Min

2000-01-01

The International Space Station (ISS) will support several facilities dedicated to scientific research. One such facility, the Biotechnology Facility (BTF), is sponsored by the Microgravity Sciences and Applications Division (MSAD) and developed at NASA's Johnson Space Center. The BTF is scheduled for delivery to the ISS via Space Shuttle in April 2005. The purpose of the BTF is to provide: (1) the support structure and integration capabilities for the individual modules in which biotechnology experiments will be performed, (2) the capability for human-tended, repetitive, long-duration biotechnology experiments, and (3) opportunities to perform repetitive experiments in a short period by allowing continuous access to microgravity. The MSAD has identified cell culture and tissue engineering, protein crystal growth, and fundamentals of biotechnology as areas that contain promising opportunities for significant advancements through low-gravity experiments. The focus of this coordinated ground- and space-based research program is the use of the low-gravity environment of space to conduct fundamental investigations leading to major advances in the understanding of basic and applied biotechnology. Results from planned investigations can be used in applications ranging from rational drug design and testing, cancer diagnosis and treatments and tissue engineering leading to replacement tissues.

Strategic alliances in healthcare: opportunities for the Veterans Affairs healthcare system.

PubMed

Halverson, P K; Kaluzny, A D; Young, G J

1997-01-01

Strategic alliances are proving to be effective strategies for responding and adapting to changing environments, and as such they offer the U.S. Department of Veterans Affairs (VA) healthcare system valuable opportunities for accomplishing the goals of its major reorganization effort. This article begins with an examination of basic strategic-alliance structures that are employed across many different types of industries. Next, consideration is given to the ways in which these basic alliance structures may be adapted to the unique organizations and individuals that serve as providers, purchasers, and consumers of health services. Finally, this article explores how models of strategic alliance in healthcare can be tailored to the specific needs and constraints of the VA healthcare system through an examination of existing and potential alliance opportunities.

Life Sciences Space Station planning document: A reference payload for the Life Sciences Research Facility

NASA Technical Reports Server (NTRS)

1986-01-01

The Space Station, projected for construction in the early 1990s, will be an orbiting, low-gravity, permanently manned facility providing unprecedented opportunities for scientific research. Facilities for Life Sciences research will include a pressurized research laboratory, attached payloads, and platforms which will allow investigators to perform experiments in the crucial areas of Space Medicine, Space Biology, Exobiology, Biospherics and Controlled Ecological Life Support System (CELSS). These studies are designed to determine the consequences of long-term exposure to space conditions, with particular emphasis on assuring the permanent presence of humans in space. The applied and basic research to be performed, using humans, animals, and plants, will increase our understanding of the effects of the space environment on basic life processes. Facilities being planned for remote observations from platforms and attached payloads of biologically important elements and compounds in space and on other planets (Exobiology) will permit exploration of the relationship between the evolution of life and the universe. Space-based, global scale observations of terrestrial biology (Biospherics) will provide data critical for understanding and ultimately managing changes in the Earth's ecosystem. The life sciences community is encouraged to participate in the research potential the Space Station facilities will make possible. This document provides the range and scope of typical life sciences experiments which could be performed within a pressurized laboratory module on Space Station.

Do we need to know more about the effects of hormones on lower urinary tract dysfunction? ICI-RS 2014.

PubMed

Hanna-Mitchell, Ann T; Robinson, Dudley; Cardozo, Linda; Everaert, Karel; Petkov, Georgi V

2016-02-01

This review article reflects the presentations and subsequent discussions during a think tank at the 5th International Consultation on Incontinence Research Society's annual meeting, held in Bristol, UK (September 22-24, 2014). It reviews the current state of knowledge on the role of hormones in lower urinary tract dysfunction (LUTD) and overactive bladder (OAB) and in particular: highlights some specific basic research findings from discussion participants; reviews future research topics; and discusses potential new therapeutic opportunities for LUTD and OAB. The role of the large conductance voltage- and Ca(2+) -activated K(+) (BK) channels, as novel therapeutic targets for OAB was discussed, in particular as recent studies on human detrusor smooth muscle suggest that estradiol exerts a direct non-genomic activation of the BK channels. Recent developments on the roles of sex hormones on diuresis, as well as the roles of melatonin and vitamin D on LUTD were also discussed. It was concluded that further basic science and translational studies are needed to better understand hormonal regulatory mechanisms of the lower urinary tract and the implications for novel treatment options for LUTD and OAB. © 2016 Wiley Periodicals, Inc.

Important role of translational science in rare disease innovation, discovery, and drug development.

PubMed

Pariser, Anne R; Gahl, William A

2014-08-01

Rare diseases play a leading role in innovation and the advancement of medical and pharmaceutical science. Most rare diseases are genetic disorders or atypical manifestations of infectious, immunologic, or oncologic diseases; they all provide opportunities to study extremes of human pathology and provide insight into both normal and aberrant physiology. Recently, drug development has become increasingly focused on classifying diseases largely on genetic grounds; this has allowed the identification of molecularly defined targets and the development of targeted therapies. Clinical trials are now focusing on progressively smaller subgroups within both common and rare disease populations, often based on genetic tests or biomarkers. Drug developers, researchers, and regulatory agencies face a variety of challenges throughout the life cycle of drug research and development for rare diseases. These include the small numbers of patients available for study, lack of knowledge of the disease's natural history, incomplete understanding of the basic mechanisms causing the disorder, and variability in disease severity, expression, and course. Traditional approaches to rare disease clinical research have not kept pace with advances in basic science, and increased attention to translational science is needed to address these challenges, especially diagnostic testing, registries, and novel trial designs.

Multidisciplinary Design Optimization Techniques: Implications and Opportunities for Fluid Dynamics Research

NASA Technical Reports Server (NTRS)

Zang, Thomas A.; Green, Lawrence L.

1999-01-01

A challenge for the fluid dynamics community is to adapt to and exploit the trend towards greater multidisciplinary focus in research and technology. The past decade has witnessed substantial growth in the research field of Multidisciplinary Design Optimization (MDO). MDO is a methodology for the design of complex engineering systems and subsystems that coherently exploits the synergism of mutually interacting phenomena. As evidenced by the papers, which appear in the biannual AIAA/USAF/NASA/ISSMO Symposia on Multidisciplinary Analysis and Optimization, the MDO technical community focuses on vehicle and system design issues. This paper provides an overview of the MDO technology field from a fluid dynamics perspective, giving emphasis to suggestions of specific applications of recent MDO technologies that can enhance fluid dynamics research itself across the spectrum, from basic flow physics to full configuration aerodynamics.

Effect of gravity on vestibular neural development

NASA Technical Reports Server (NTRS)

Ross, M. D.; Tomko, D. L.

1998-01-01

The timing, molecular basis, and morphophysiological and behavioral consequences of the interaction between external environment and the internal genetic pool that shapes the nervous system over a lifetime remain important questions in basic neuroscientific research. Space station offers the opportunity to study this interaction over several life cycles in a variety of organisms. This short review considers past work in altered gravity, particularly on the vestibular system, as the basis for proposing future research on space station, and discusses the equipment necessary to achieve goals. It is stressed that, in keeping with the international investment being made in this research endeavor, both the questions asked and the technologies to be developed should be bold. Advantage must be taken of this unique research environment to expand the frontiers of neuroscience. Copyright 1998 Published by Elsevier Science B.V.

Boosting Low-Income Children's Opportunities to Succeed Through Direct Income Support.

PubMed

Sherman, Arloc; DeBot, Brandon; Huang, Chye-Ching

2016-04-01

Direct income supports have long been known to substantially reduce the extent and depth of poverty. Evidence suggests that they can also bolster children's opportunities to succeed and enhance long-term mobility. A growing body of research, for example, links income from 2 related tax credits for working families-the Earned Income Tax Credit and the Child Tax Credit-to benefits for children in those families, such as improved birth weight, better school outcomes, and increased rates of employment in adulthood. Similarly, the introduction of food stamps has been found to improve not only the birth weight of infants given access to the program but also their educational achievement, as well as indicators of health, well-being, and self-sufficiency decades later. These are striking research results for income support that is not typically thought of as improving children's health or education. The mechanisms through which these income supports lead to such benefits are likely varied and complex, but emerging research suggests that helping families with children afford basic necessities can reduce the added stress of financial difficulties, preventing downstream neuroendocrine and biochemical changes that affect children's longer-term outcomes. These findings have important implications for policy makers. Research suggests that potential weakening of the safety net would not only substantially increase poverty, but also have damaging long-term effects on children. Policy makers should reject funding cuts and instead strengthen the safety net, which this analysis suggests could reduce poverty further and also enhance children's opportunities to succeed. Copyright © 2016. Published by Elsevier Inc.

The triple helix--NIH, industry, and the academic world.

PubMed Central

Lowe, C. U.

1982-01-01

Spectacular accomplishments in biomedical research have given birth to what is now perceived as a biological revolution, an epoch in which man has acquired the skill to manipulate the fundamental unit of heredity, the gene. This revolution carries with it the prospect of remarkable opportunities to improve the quality of life and to probe with increasing precision the mysteries of cellular organization and function. It comes, however, at a time when the opportunity to exploit this new knowledge may be limited by a significant reduction in federal support of basic research, and a situation which prompts universities and other centers of scientific activity to seek funding from industrial patrons. This trend has generated a new constellation of institutional challenges, for one apparent result of industrial sponsorship of university-based biomedical research is a threat to university governance as altered allegiances emerge and as the potential for financial gain appears almost limitless. This essay explores background issues leading to these new alliances, seeks to identify some of the central problems emerging for university administrators, faculty, and students, and then poses a key question: Can industrial support for university-based biomedical research fill the apparent short-fall in federal dollars in the foreseeable future? An analysis of available data indicates that this outcome is unlikely either now or in the years ahead. PMID:7180024

[Actual state and problems in neurology training at graduate school].

PubMed

Kira, Jun-ichi; Ohyagi, Yasumasa; Taniwaki, Takayuki; Inuzuka, Takashi; Yoshii, Fumihito; Aoki, Masashi; Amano, Takahiro; Toyoshima, Itaru; Fukutake, Toshio; Hashimoto, Yoichiro

2014-01-01

To understand the status of postgraduate education in neurology in Japan, the Committee for the Education of Undergraduate Students and Junior Residents within the Japanese Society of Neurology investigated the four-year trend at 80 medical schools from 2009 to 2012. The mean number of new students to each postgraduate school increased from 1.24 to 1.67 during these four years. After training clinical neurology, more than half of the neurological residents entered the postgraduate schools. Students in the postgraduate schools seemed to be researching major neurological diseases using various methods at each neurology laboratory. However, some problems were suggested. First, the mean number of newcomers to the neurology departments of the universities decreased gradually from 2.29/year to 1.96/year. Second, many of the postgraduate students were working in patient services at university hospitals or as part-time workers at other hospitals, and may not have sufficient time for their research projects. Third, many of the postgraduate students were carrying out research at each affiliated department of neurology, and may not have the opportunity to work in laboratories specializing in basic science. Finally, there may not be sufficient opportunities for further research at other laboratories in Japan or overseas after they finished their work at postgraduate school.

Integrating the dimensions of sex and gender into basic life sciences research: methodologic and ethical issues.

PubMed

Holdcroft, Anita

2007-01-01

The research process -- from study design and selecting a species and its husbandry, through the experiment, analysis, peer review, and publication -- is rarely subject to questions about sex or gender differences in mainstream life sciences research. However, the impact of sex and gender on these processes is important in explaining biological variations and presentation of symptoms and diseases. This review aims to challenge assumptions and to develop opportunities to mainstream sex and gender in basic scientific research. Questions about the mechanisms of sex and gender effects were reviewed in relation to biological, environmental, social, and psychological interactions. Gender variations, in respect to aging, socializing, and reproduction, that are present in human populations but are rarely featured in laboratory research were considered to more effectively translate animal research into clinical health care. Methodologic approaches to address the present lack of a gender dimension in research include actively reducing variations through attention to physical factors, biological rhythms, and experimental design. In addition, through genomic and acute nongenomic activity, hormones may compound effects through multiple small sex differences that occur during the course of an acute pathologic event. Furthermore, the many exogenous sex steroid hormones and their congeners used in medicine (eg, in contraception and cancer therapies) may add to these effects. The studies reviewed provide evidence that sex and gender are determinants of many outcomes in life science research. To embed the gender dimension into basic scientific research, a broad approach -- gender mainstreaming -- is warranted. One example is the use of review boards (eg, animal ethical review boards and journal peer-review boards) in which gender-related standardized questions can be asked about study design and analysis. A more fundamental approach is to question the relevance of present-day laboratory models to design methods to best represent the age-related changes, comorbidity, and variations experienced by each sex in clinical medicine.

Systems Based Approaches for Conversion of Biomass to Bioenergy and Bioproducts

DOE Office of Scientific and Technical Information (OSTI.GOV)

Taylor, Steve; McDonald, Timothy; Adhikari, Sushil

The research provided data on applicability of agricultural energy crops and forest biomass production and logistics models. While much of the overall research effort was focused on lignocellulosic feedstocks, the research also recognized that there are important opportunities for the production and use of starch-based agricultural crops to serve as alternative regionally-appropriate biofuel feedstocks. Also, the research identified fractionation techniques that can be used to separate biomass feedstocks into their basic chemical constituents and then streamline the biorefining industry by developing commodity products for cellulose, hemicellulose, and lignin. Finally, models and techniques were developed to determine economically feasible technologies formore » production of biomass-derived synthesis gases that can be used for clean, renewable power generation and for production of liquid transportation fuels through Fischer-Tropsch Synthesis. Moreover, this research program educated the next generation of engineers and scientists needed to implement these technologies.« less

Current Status of Sperm Cryopreservation in Biomedical Research Fish Models: Zebrafish, Medaka, and Xiphophorus*

PubMed Central

Yang, Huiping; Tiersch, Terrence R.

2009-01-01

Aquarium fishes are becoming increasingly important because of their value in biomedical research and the ornamental fish trade, and because many have become threatened or endangered in the wild. This review summarizes the current status of sperm cryopreservation in three fishes widely used in biomedical research: zebrafish, medaka, and live-bearing fishes of the genus Xiphophorus, and will focus on the needs and opportunities for future research and application of cryopreservation in aquarium fish. First, we summarize the basic biological characteristics regarding natural habitat, testis structure, spermatogenesis, sperm morphology, and sperm physiology. Second, we compare protocol development of sperm cryopreservation. Third, we emphasize the importance of artificial fertilization in sperm cryopreservation to evaluate the viability of thawed sperm. We conclude with a look to future research directions for sperm cryopreservation and the application of this technique in aquarium species. PMID:18691673

Being a Scientist While Teaching Science: Implementing Undergraduate Research Opportunities for Elementary Educators

NASA Astrophysics Data System (ADS)

Hock, Emily; Sharp, Zoe

2016-03-01

Aspiring teachers and current teachers can gain insight about the scientific community through hands-on experience. As America's standards for elementary school and middle school become more advanced, future and current teachers must gain hands-on experience in the scientific community. For a teacher to be fully capable of teaching all subjects, they must be comfortable in the content areas, equipped to answer questions, and able to pass on their knowledge. Hands-on research experiences, like the Summer Astronomy Research Experience at California Polytechnic University, pair liberal studies students with a cooperative group of science students and instructors with the goal of doing research that benefits the scientific community and deepens the team members' perception of the scientific community. Teachers are then able to apply the basic research process in their classrooms, inspire students to do real life science, and understand the processes scientists' undergo in their workplace.

Establishing a successful clinical research program.

PubMed

Scoglio, Daniele; Fichera, Alessandro

2014-06-01

Clinical research (CR) is a natural corollary to clinical surgery. It gives an investigator the opportunity to critically review their results and develop new strategies. This article covers the critical factors and the important components of a successful CR program. The first and most important step is to build a dedicated research team to overcome time constraints and enable a surgical practice to make CR a priority. With the research team in place, the next step is to create a program on the basis of an original idea and new clinical hypotheses. This often comes from personal experience supported by a review of the available evidence. Randomized controlled (clinical) trials are the most stringent way of determining whether a cause-effect relationship exists between the intervention and the outcome. In the proper setting, translational research may offer additional avenues allowing clinical application of basic science discoveries.

Equal Educational Opportunity. The Status of Black Americans in Higher Education, 1975-1977. ISEP Third Status Report.

ERIC Educational Resources Information Center

Howard Univ., Washington, DC. Inst. for the Study of Educational Policy.

This report analyzes the status of black Americans in higher education from 1975-1977. The book opens with a review of basic concepts of equal educational opportunity and the Federal role in guaranteeing equal opportunity. The social and economic context for higher education is then examined with a focus on the national commitment to higher…

Careers Guide: Opportunities in the Professions, Industry and Commerce.

ERIC Educational Resources Information Center

Central Youth Employment Executive, London (England).

This directory contains basic occupational information about 100 career opportunities in business, industry, and the professions in Great Britain. Entry-level employment qualifications, brief job descriptions, salary ranges, employment projections, and resource addresses are provided for each career. Educational and training requirements are…

Women--Their Access to Education and Employment

ERIC Educational Resources Information Center

Literacy Discussion, 1975

1975-01-01

The Unesco National Commissions carried out a series of studies simultaneously in Argentina, the Ivory Coast, Lebanon, Sierra Leone, and Sri Lanka regarding the relationship between the educational opportunities and the opportunities of employment open to women. Basic conclusions of international scope are presented. (LH)

3 CFR 8913 - Proclamation 8913 of December 3, 2012. International Day of Persons With Disabilities, 2012

Code of Federal Regulations, 2013 CFR

2013-01-01

... shot at opportunity, all of us do better. For more than two decades, our country has upheld those basic... by the belief that equal access and equal opportunity are common principles that unite us as one...

Engage: The Science Speaker Series - A novel approach to improving science outreach and communication

NASA Astrophysics Data System (ADS)

Mitchell, R.; Hilton, E.; Rosenfield, P.

2011-12-01

Communicating the results and significance of basic research to the general public is of critical importance. Federal funding and university budgets are under substantial pressure, and taxpayer support of basic research is critical. Public outreach by ecologists is an important vehicle for increasing support and understanding of science in an era of anthropogenic global change. At present, very few programs or courses exist to allow young scientists the opportunity to hone and practice their public outreach skills. Although the need for science outreach and communication is recognized, graduate programs often fail to provide any training in making science accessible. Engage: The Science Speaker Series represents a unique, graduate student-led effort to improve public outreach skills. Founded in 2009, Engage was created by three science graduate students at the University of Washington. The students developed a novel, interdisciplinary curriculum to investigate why science outreach often fails, to improve graduate student communication skills, and to help students create a dynamic, public-friendly talk. The course incorporates elements of story-telling, improvisational arts, and development of analogy, all with a focus on clarity, brevity and accessibility. This course was offered to graduate students and post-doctoral researchers from a wide variety of sciences in the autumn of 2010. Students who participated in the Engage course were then given the opportunity to participate in Engage: The Science Speaker Series. This free, public-friendly speaker series is hosted on the University of Washington campus and has had substantial public attendance and participation. The growing success of Engage illustrates the need for such programs throughout graduate level science curricula. We present the impetus for the development of the program, elements of the curriculum covered in the Engage course, the importance of an interdisciplinary approach, and discuss strategies for implementing similar programs at research institutions nationally.

Engage: The Science Speaker Series - A novel approach to improving science outreach and communication

NASA Astrophysics Data System (ADS)

Mitchell, R.; Hilton, E.; Rosenfield, P.

2012-12-01

Communicating the results and significance of basic research to the general public is of critical importance. Federal funding and university budgets are under substantial pressure, and taxpayer support of basic research is critical. Public outreach by ecologists is an important vehicle for increasing support and understanding of science in an era of anthropogenic global change. At present, very few programs or courses exist to allow young scientists the opportunity to hone and practice their public outreach skills. Although the need for science outreach and communication is recognized, graduate programs often fail to provide any training in making science accessible. Engage: The Science Speaker Series represents a unique, graduate student-led effort to improve public outreach skills. Founded in 2009, Engage was created by three science graduate students at the University of Washington. The students developed a novel, interdisciplinary curriculum to investigate why science outreach often fails, to improve graduate student communication skills, and to help students create a dynamic, public-friendly talk. The course incorporates elements of story-telling, improvisational arts, and development of analogy, all with a focus on clarity, brevity and accessibility. This course was offered to graduate students and post-doctoral researchers from a wide variety of sciences in the autumn of 2010 and 2011, and will be retaught in 2012. Students who participated in the Engage course were then given the opportunity to participate in Engage: The Science Speaker Series. This free, public-friendly speaker series has been hosted at the University of Washington campus and Seattle Town Hall, and has had substantial public attendance and participation. The growing success of Engage illustrates the need for such programs throughout graduate level science curricula. We present the impetus for the development of the program, elements of the curriculum covered in the Engage course, the importance of an interdisciplinary approach, and discuss strategies for implementing similar programs at research institutions nationally.

Opportunities for Undergraduate Research in Nuclear Physics

DOE PAGES

Hicks, S. F.; Nguyen, T. D.; Jackson, D. T.; ...

2017-10-26

University of Dallas (UD) physics majors are offered a variety of undergraduate research opportunities in nuclear physics through an established program at the University of Kentucky Accelerator Laboratory (UKAL). The 7-MV Model CN Van de Graaff accelerator and the neutron production and detection facilities located there are used by UD students to investigate how neutrons scatter from materials that are important in nuclear energy production and for our basic understanding of how neutrons interact with matter. Recent student projects include modeling of the laboratory using the neutron transport code MCNP to investigate the effectiveness of laboratory shielding, testing the long-termmore » gain stability of C 6D 6 liquid scintillation detectors, and deducing neutron elastic and inelastic scattering cross sections for 12C. Finally, results of these student projects are presented that indicate the pit below the scattering area reduces background by as much as 30%; the detectors show no significant gain instabilities; and new insights into existing 12C neutron inelastic scattering cross-section discrepancies near a neutron energy of 6.0 MeV are obtained.« less

The Grand Challenges of Organ Banking: Proceedings from the first global summit on complex tissue cryopreservation.

PubMed

Lewis, Jedediah K; Bischof, John C; Braslavsky, Ido; Brockbank, Kelvin G M; Fahy, Gregory M; Fuller, Barry J; Rabin, Yoed; Tocchio, Alessandro; Woods, Erik J; Wowk, Brian G; Acker, Jason P; Giwa, Sebastian

2016-04-01

The first Organ Banking Summit was convened from Feb. 27 - March 1, 2015 in Palo Alto, CA, with events at Stanford University, NASA Research Park, and Lawrence Berkeley National Labs. Experts at the summit outlined the potential public health impact of organ banking, discussed the major remaining scientific challenges that need to be overcome in order to bank organs, and identified key opportunities to accelerate progress toward this goal. Many areas of public health could be revolutionized by the banking of organs and other complex tissues, including transplantation, oncofertility, tissue engineering, trauma medicine and emergency preparedness, basic biomedical research and drug discovery - and even space travel. Key remaining scientific sub-challenges were discussed including ice nucleation and growth, cryoprotectant and osmotic toxicities, chilling injury, thermo-mechanical stress, the need for rapid and uniform rewarming, and ischemia/reperfusion injury. A variety of opportunities to overcome these challenge areas were discussed, i.e. preconditioning for enhanced stress tolerance, nanoparticle rewarming, cyroprotectant screening strategies, and the use of cryoprotectant cocktails including ice binding agents. Copyright © 2015.

Smartphones Offer New Opportunities in Clinical Voice Research.

PubMed

Manfredi, C; Lebacq, J; Cantarella, G; Schoentgen, J; Orlandi, S; Bandini, A; DeJonckere, P H

2017-01-01

Smartphone technology provides new opportunities for recording standardized voice samples of patients and sending the files by e-mail to the voice laboratory. This drastically improves the collection of baseline data, as used in research on efficiency of voice treatments. However, the basic requirement is the suitability of smartphones for recording and digitizing pathologic voices (mainly characterized by period perturbations and noise) without significant distortion. In this experiment, two smartphones (a very inexpensive one and a high-level one) were tested and compared with direct microphone recordings in a soundproof room. The voice stimuli consisted in synthesized deviant voice samples (median of fundamental frequency: 120 and 200 Hz) with three levels of jitter and three levels of added noise. All voice samples were analyzed using PRAAT software. The results show high correlations between jitter, shimmer, and noise-to-harmonics ratio measured on the recordings via both smartphones, the microphone, and measured directly on the sound files from the synthesizer. Smartphones thus appear adequate for reliable recording and digitizing of pathologic voices. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

From agricultural geology to hydropedology: Forging links within the twenty-first-century geoscience community

USGS Publications Warehouse

Landa, E.R.; ,

2006-01-01

Despite historical linkages, the fields of geology and soil science have developed along largely divergent paths in the United States during much of the mid- to late-twentieth century. The shift in recent decades within both disciplines, towards greater emphasis on environmental-quality issues and a systems approach, has created new opportunities for collaboration and cross-training. Because of the importance of the soil as a dynamic interface between the hydrosphere, biosphere, atmosphere and lithosphere, introductory and advanced soil-science classes are now taught in a number of Earth and environmental science departments. The National Research Council's recent report, Basic Research Opportunities in Earth Science, highlights the soil zone as part of the land surface to groundwater 'critical zone' requiring additional investigation. To better prepare geology undergraduates to deal with complex environmental problems, their training should include a fundamental understanding of the nature and properties of soils. Those undergraduate geology students with an interest in this area should be encouraged to view soil science as a viable Earth-science specialty area for graduate study. ?? The Geological Society of London 2006.

Opportunities for Undergraduate Research in Nuclear Physics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hicks, S. F.; Nguyen, T. D.; Jackson, D. T.

University of Dallas (UD) physics majors are offered a variety of undergraduate research opportunities in nuclear physics through an established program at the University of Kentucky Accelerator Laboratory (UKAL). The 7-MV Model CN Van de Graaff accelerator and the neutron production and detection facilities located there are used by UD students to investigate how neutrons scatter from materials that are important in nuclear energy production and for our basic understanding of how neutrons interact with matter. Recent student projects include modeling of the laboratory using the neutron transport code MCNP to investigate the effectiveness of laboratory shielding, testing the long-termmore » gain stability of C 6D 6 liquid scintillation detectors, and deducing neutron elastic and inelastic scattering cross sections for 12C. Finally, results of these student projects are presented that indicate the pit below the scattering area reduces background by as much as 30%; the detectors show no significant gain instabilities; and new insights into existing 12C neutron inelastic scattering cross-section discrepancies near a neutron energy of 6.0 MeV are obtained.« less

Investigation of the High Latitude Magnetosphere and its Response to the Solar Wind

NASA Technical Reports Server (NTRS)

Taylor, William W. L.

1996-01-01

INSPIRE is a non-profit scientific, educational corporation whose objective is to bring the excitement of observing natural and manmade radio waves in the audio region to high school students. Stimulating students to learn and understand science and technology is the key to them fulfilling their potential in the best interests of our society. INSPIRE also is an innovative, unique opportunity for students to actively gather data that might be used in a basic research project. INSPIRE began with a test bed project, ACTIVE/HSGS, which involved 100 high schools, with a centerpiece of making observations of 10.5 kHz transmissions from the Soviet ACTIVE satellite. A large number of ground receiving sites was needed, both to enhance the probability of receiving the radio waves from ACTIVE, and to determine the propagation paths to the ground. The second major project was support to SEPAC (Space Experiments using Particle ACcelerators), a payload on the ATLAS I Spacelab mission, flown in March/April 1992. With its electron accelerator SEPAC performed many experiments in the ionosphere, including producing an artificial aurora and the electromagnetic waves produced by pulsing the electron beam. INSPIRE/SEPAC provided more than 1000 ground stations to receive the radio waves, and, at the same time, allowed high school students the opportunity to take data that would be used in a published basic research project. The third major project is to make observations of the effects of a pulsed electron beam and plasma generator on the MIR Space Station. On request, these instruments are operated over INSPIRE observers.

Moving Toward Integrative, Multidimensional Research in Modern Psychiatry: Lessons Learned From Fragile X Syndrome.

PubMed

Fung, Lawrence K; Reiss, Allan L

2016-07-15

The field of psychiatry is approaching a major inflection point. The basic science behind cognition, emotion, behavior, and social processes has been advancing rapidly in the past 20 years. However, clinical research supporting the classification system in psychiatry has not kept up with these scientific advances. To begin organizing the basic science of psychiatry in a comprehensive manner, we begin by selecting fragile X syndrome, a neurogenetic disease with cognitive-behavioral manifestations, to illustrate key concepts in an integrative, multidimensional model. Specifically, we describe key genetic and molecular mechanisms (e.g., gamma-aminobutyric acidergic dysfunction and metabotropic glutamate receptor 5-associated long-term depression) relevant to the pathophysiology of fragile X syndrome as well as neural correlates of cognitive-behavioral symptoms. We then describe what we have learned from fragile X syndrome that may be applicable to other psychiatric disorders. We conclude this review by discussing current and future opportunities in diagnosing and treating psychiatric diseases. Copyright © 2016 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Global Security, Medical Isotopes, and Nuclear Science

NASA Astrophysics Data System (ADS)

Ahle, Larry

2007-10-01

Over the past century basic nuclear science research has led to the use of radioactive isotopes into a wide variety of applications that touch our lives everyday. Some are obvious, such as isotopes for medical diagnostics and treatment. Others are less so, such as National/Global security issues. And some we take for granted, like the small amount of 241 Am that is in every smoke detector. At the beginning of this century, we are in a position where the prevalence and importance of some applications of nuclear science are pushing the basic nuclear science community for improved models and nuclear data. Yet, at the same time, the push by the basic nuclear science community to study nuclei that are farther and farther away from stability also offer new opportunities for many applications. This talk will look at several global security applications of nuclear science, summarizing current R&D and need for improved nuclear data It will also look at how applications of nuclear science, such as to medicine, will benefit from the push for more and more powerful radioactive ion beam facilities.

Educational Opportunities for Clinical Counseling Simulations in Second Life

ERIC Educational Resources Information Center

Walker, Victoria L.; Rockinson-Szapkiw, Amanda

2009-01-01

Counseling students must learn and practice basic counseling skills, including attending, listening, empathizing, and demonstrating warmth and respect. For online educators, providing opportunities for students to develop these skills in realistic counseling situations can be difficult. Victoria L. Walker and Amanda Rockinson-Szapkiw describe how…

NASA's Universe of Learning: The Integral Role of Research Astronomers and Other Subject Matter Experts

NASA Astrophysics Data System (ADS)

Lee, Janice; Universe of Learning Team

2018-01-01

Astronomy seeks to understand the workings of the Universe on its largest scales, and to answer fundamental questions about the story of our origins. The science of astronomy thus naturally lends itself to informal education and public outreach activities, as it broadly captures the human imagination. There are at least three overall goals for investment of resources in Astronomy E/PO: to interest students in pursuing STEM education and careers; to develop Astronomy as context for teaching more basic physical and computer science in service of US National Education Goals; to help motivate continued public support of federally funded Astronomy research and technology development. Providing a full spectrum of opportunities for the public to learn about recent Astronomy discoveries is key to achieving these societal goals. Thus, the E/PO professional community must have an understanding of recent scientific/technological results, and engage with the researchers who are creating new knowledge to explicate that knowledge to the public. It stands to reason that researchers (or “subject matter experts, SMEs”) must be involved in and remain connected to the E/PO endeavor. In this talk, I will describe how research astronomers and other SMEs play an integral role in a full range of informal education programming developed by the NASA Universe of Learning collaboration, and opportunities to get involved.

Financial anatomy of biomedical research.

PubMed

Moses, Hamilton; Dorsey, E Ray; Matheson, David H M; Thier, Samuel O

2005-09-21

Public and private financial support of biomedical research have increased over the past decade. Few comprehensive analyses of the sources and uses of funds are available. This results in inadequate information on which to base investment decisions because not all sources allow equal latitude to explore hypotheses having scientific or clinical importance and creates a barrier to judging the value of research to society. To quantify funding trends from 1994 to 2004 of basic, translational, and clinical biomedical research by principal sponsors based in the United States. Publicly available data were compiled for the federal, state, and local governments; foundations; charities; universities; and industry. Proprietary (by subscription but openly available) databases were used to supplement public sources. Total actual research spending, growth rates, and type of research with inflation adjustment. Biomedical research funding increased from 37.1 billion dollars in 1994 to 94.3 billion dollars in 2003 and doubled when adjusted for inflation. Principal research sponsors in 2003 were industry (57%) and the National Institutes of Health (28%). Relative proportions from all public and private sources did not change. Industry sponsorship of clinical trials increased from 4.0 dollars to 14.2 billion dollars (in real terms) while federal proportions devoted to basic and applied research were unchanged. The United States spent an estimated 5.6% of its total health expenditures on biomedical research, more than any other country, but less than 0.1% for health services research. From an economic perspective, biotechnology and medical device companies were most productive, as measured by new diagnostic and therapeutic devices per dollar of research and development cost. Productivity declined for new pharmaceuticals. Enhancing research productivity and evaluation of benefit are pressing challenges, requiring (1) more effective translation of basic scientific knowledge to clinical application; (2) critical appraisal of rapidly moving scientific areas to guide investment where clinical need is greatest, not only where commercial opportunity is currently perceived; and (3) more specific information about sources and uses of research funds than is generally available to allow informed investment decisions. Responsibility falls on industry, government, and foundations to bring these changes about with a longer-term view of research value.

Drafting--Basic, Drafting--Intermediate: 9255.01.

ERIC Educational Resources Information Center

Dade County Public Schools, Miami, FL.

The course has no prerequisites, offers instruction in basic drafting room techniques and procedures, and also covers job opportunities and industrial methods in engineering. The student is introduced to and asked to perform fundamental drafting problems with working drawings, using multiview and auxiliary views and sections. The course also…

[Aims and core contents of basic and post basic courses of nursing management].

PubMed

Saiani, Luisa; Brugnolli, Anna

2006-01-01

The second part of the issue, dedicated to the nursing management offers a discussion on some of the relevant areas of debate for the organization of nursing care. A reflection on the core contents and main aims of basic and post basic (master, advanced level, specialistic degree) nursing courses is proposed in the first contribution. Then a selection of topics is presented, focusing on the main research contributions available in the literature and on the ongoing debate for the following areas: the role of communication at the inter-shift handover and the new model of bedside reporting; the problems and challenges of doctors nurses collaboration in the health care team; the problems and expectations of new nurses joining the health care team and the process of development of practical skills; the hot debate on nursing roles and level of practice and the difficulties in differentiating between elementary, specialist and advanced nursing practice; the new emerging roles: the characteristics and achievements of Nurse Consultant; the new challenges of coordinators of the health care teams with the management of the multigenerational nursing team. For each topic a definition of the problem is presented, an example of relevant study, a critical debate and suggestions for further studies and areas of research. A list of the main journals that deal with nursing management is proposed with comments on the main characteristics of each journal. A study protocol that aims at describing the outcomes of the different styles and models of organization of medical wards on patients and nurses is presented as an example of organizative research; an experience of, and a model for, participation of the nurses to health policy planning is proposed. Nurses were, asked to identify health care problems encountered in their daily practice, their causes and propose solutions at basic and policy level. The session of International Observatory explores the main problems and difficulties of the research on the organization of care, focusing more on opportunities than on the challenges and drawbacks of the available literature.

Research Associate | Center for Cancer Research

Cancer.gov

The Basic Science Program (BSP) at the Frederick National Laboratory for Cancer Research (FNLCR) pursues independent, multidisciplinary research programs in basic or applied molecular biology, immunology, retrovirology, cancer biology or human genetics. As part of the BSP, the Microbiome and Genetics Core (the Core) characterizes microbiomes by next-generation sequencing to determine their composition and variation, as influenced by immune, genetic, and host health factors. The Core provides support across a spectrum of processes, from nucleic acid isolation through bioinformatics and statistical analysis. KEY ROLES/RESPONSIBILITIES The Research Associate II will provide support in the areas of automated isolation, preparation, PCR and sequencing of DNA on next generation platforms (Illumina MiSeq and NextSeq). An opportunity exists to join the Core’s team of highly trained experimentalists and bioinformaticians working to characterize microbiome samples. The following represent requirements of the position: A minimum of five (5) years related of biomedical experience. Experience with high-throughput nucleic acid (DNA/RNA) extraction. Experience in performing PCR amplification (including quantitative real-time PCR). Experience or familiarity with robotic liquid handling protocols (especially on the Eppendorf epMotion 5073 or 5075 platforms). Experience in operating and maintaining benchtop Illumina sequencers (MiSeq and NextSeq). Ability to evaluate experimental quality and to troubleshoot molecular biology protocols. Experience with sample tracking, inventory management and biobanking. Ability to operate and communicate effectively in a team-oriented work environment.

Sustainability in care through an ethical practice model.

PubMed

Nyholm, Linda; Salmela, Susanne; Nyström, Lisbet; Koskinen, Camilla

2018-03-01

While sustainability is a key concept in many different domains today, it has not yet been sufficiently emphasized in the healthcare sector. Earlier research shows that ethical values and evidence-based care models create sustainability in care practice. The aim of this study was to gain further understanding of the ethical values central to the realization of sustainability in care and to create an ethical practice model whereby these basic values can be made perceptible and active in care practice. Part of the ongoing "Ethical Sustainable Caring Cultures" research project, a hermeneutical application research design was employed in this study. Dialogues were used, where scientific researchers and co-researchers were given the opportunity to reflect on ethical values in relation to sustainability in care. An ethical practice model with ethos as its core was created from the results of the dialogues. In the model, ethos is encircled by the ethical values central to sustainability: dignity, responsibility, respect, invitation, and vows. The model can be used as a starting point for ethical conversations that support carers' reflections on the ethical issues seen in day-to-day care work and the work community, allowing ethical values to become visible throughout the entire care culture. It is intended as a tool whereby carers can more deeply understand an organization's common basic values and what they entail in regard to sustainability in care.

State of the art: dual-energy CT of the abdomen.

PubMed

Marin, Daniele; Boll, Daniel T; Mileto, Achille; Nelson, Rendon C

2014-05-01

Recent technologic advances in computed tomography (CT)--enabling the nearly simultaneous acquisition of clinical images using two different x-ray energy spectra--have sparked renewed interest in dual-energy CT. By interrogating the unique characteristics of different materials at different x-ray energies, dual-energy CT can be used to provide quantitative information about tissue composition, overcoming the limitations of attenuation-based conventional single-energy CT imaging. In the past few years, intensive research efforts have been devoted to exploiting the unique and powerful opportunities of dual-energy CT for a variety of clinical applications. This has led to CT protocol modifications for radiation dose reduction, improved diagnostic performance for detection and characterization of diseases, as well as image quality optimization. In this review, the authors discuss the basic principles, instrumentation and design, examples of current clinical applications in the abdomen and pelvis, and future opportunities of dual-energy CT.

New research opportunities for roadside safety barriers improvement

NASA Astrophysics Data System (ADS)

Cantisani, Giuseppe; Di Mascio, Paola; Polidori, Carlo

2017-09-01

Among the major topics regarding the protection of roads, restraint systems still represent a big opportunity in order to increase safety performances. When accidents happen, in fact, the infrastructure can substantially contribute to the reduction of consequences if its marginal spaces are well designed and/or effective restraint systems are installed there. Nevertheless, basic concepts and technology of road safety barriers have not significantly changed for the last two decades. The paper proposes a new approach to the study aimed to define possible enhancements of restraint safety systems performances, by using new materials and defining innovative design principles. In particular, roadside systems can be developed with regard to vehicle-barrier interaction, vehicle-oriented design (included low-mass and extremely low-mass vehicles), traffic suitability, user protection, working width reduction. In addition, thanks to sensors embedded into the barriers, it is also expected to deal with new challenges related to the guidance of automatic vehicles and I2V communication.

Cell and molecular mechanics of biological materials

NASA Astrophysics Data System (ADS)

Bao, G.; Suresh, S.

2003-11-01

Living cells can sense mechanical forces and convert them into biological responses. Similarly, biological and biochemical signals are known to influence the abilities of cells to sense, generate and bear mechanical forces. Studies into the mechanics of single cells, subcellular components and biological molecules have rapidly evolved during the past decade with significant implications for biotechnology and human health. This progress has been facilitated by new capabilities for measuring forces and displacements with piconewton and nanometre resolutions, respectively, and by improvements in bio-imaging. Details of mechanical, chemical and biological interactions in cells remain elusive. However, the mechanical deformation of proteins and nucleic acids may provide key insights for understanding the changes in cellular structure, response and function under force, and offer new opportunities for the diagnosis and treatment of disease. This review discusses some basic features of the deformation of single cells and biomolecules, and examines opportunities for further research.

Physics Education in a Multidisciplinary Materials Research Environment

NASA Astrophysics Data System (ADS)

Doyle, W. D.

1997-03-01

The MINT Center, an NSF Materials Research Science and Engineering Center, is a multidisciplinary research program focusing on materials information storage. It involves 17 faculty, 10 post-doctoral fellows and 25 graduate students from six academic programs including Physics, Chemistry, Materials Science, Metallurgical and Materials Engineering, Electric al Engineering and Chemical Engineering, whose research is supported by university, federal and industrial funds. The research facilities (15,000 ft^2) which include faculty and student offices are located in one building and are maintained by the university and the Center at no cost to participating faculty. The academic requirements for the students are determined by the individual departments along relatively rigid, traditional grounds although several materials and device courses are offered for students from all departments. Within the Center, participants work in teams assigning responsibilities and sharing results at regularly scheduled meetings. Bi-weekly research seminars for all participants provide excellent opportunities for students to improve their communication skills and to receive critical input from a large, diverse audience. Strong collaboration with industrial partners in the storage industry supported by workshops, research reviews, internships, industrial visitors and participation in industry consortia give students a broader criteria for self-evaluation, higher motivation and excellent career opportunities. Physics students, because of their rigorous basic training, are an important element in a strong materials sciences program, but they often are deficient in the behavior and characterization of real materials. The curriculum for physics students should be broadened to prepare them fully for a rewarding career in this emerging discipline.

National Institutes of Health Funding for Obstructive Sleep Apnea: An Opportunity for Otolaryngologists.

PubMed

Gouveia, Christopher J; Qureshi, Hannan A; Kern, Robert C; Shintani Smith, Stephanie

2015-10-01

To describe current levels and trends of funding for the National Institutes of Health (NIH) in obstructive sleep apnea (OSA) and to recognize the current status of otolaryngologists in OSA research. Scientometric analysis. The NIH RePORTER database was queried for the search term "obstructive sleep apnea" for all available years. Sex, degree, academic department, NIH funding source, geography, funding totals and years, and h-index of principal investigators (PIs) were collected and summarized. A total of 397 projects spanning 1242 total funding years were funded. Of the 273 individual PIs, 33.3% (91/273) were female. Regarding credentials, 52.4% of PIs (143/273) were MD or MD/PhD, and 41.0% (112/273) were PhD alone. Academic departments of PIs were most often medicine (34.1%), pediatrics (12.1%), cell biology/physiology (10.6%), and psychiatry (7.7%). Seven otolaryngology faculty members had received NIH funding for OSA research (2.6% of total PIs) since 2000. They accounted for 8 grants (0.25% of total grants) and $7,235,729 (1.5% of total dollars) of research funding. Despite studies showing increasing levels of OSA surgery being performed and major areas of research and clinical opportunity, otolaryngologists represent a small minority of OSA research funding. This information may help direct our specialty when setting priorities regarding research funding, as research into the basic science and clinical management of OSA represents a broad and interdisciplinary pursuit. © American Academy of Otolaryngology-Head and Neck Surgery Foundation 2015.

Developing a heart institute: the execution of a strategic plan.

PubMed

Krawczeski, Catherine D; McDonald, Mark B

2013-01-01

The Heart Institute at Cincinnati Children's Hospital Medical Center was chartered in July 2008 with the purpose of integrating clinical cardiovascular medicine with basic science research to foster innovations in care of patients with congenital heart problems. The initial administrative steering committee included representation from a basic scientist, a cardiologist, and a cardiothoracic surgeon and was charged with the development of a strategic plan for the evolution of the Institute over a five-year horizon. Using structured focus groups and staff interviews, the vision, mission, and goals were identified and refined. An integrated implementation plan addressing recruitment, capitalization, infrastructure, and market opportunities was created and executed. The preliminary results demonstrated clinical outcome improvements, increased scientific and academic productivity, and financial sustainability. All of the goals identified in the initial planning sequence were achieved within the five-year time frame, prompting an early evaluation and revision of the strategic plan.

NIH Roundtable on Opportunities to Advance Research on Neurologic and Psychiatric Emergencies.

PubMed

D'Onofrio, Gail; Jauch, Edward; Jagoda, Andrew; Allen, Michael H; Anglin, Deirdre; Barsan, William G; Berger, Rachel P; Bobrow, Bentley J; Boudreaux, Edwin D; Bushnell, Cheryl; Chan, Yu-Feng; Currier, Glenn; Eggly, Susan; Ichord, Rebecca; Larkin, Gregory L; Laskowitz, Daniel; Neumar, Robert W; Newman-Toker, David E; Quinn, James; Shear, Katherine; Todd, Knox H; Zatzick, Douglas

2010-11-01

The Institute of Medicine Committee on the Future of Emergency Care in the United States Health System (2003) identified a need to enhance the research base for emergency care. As a result, a National Institutes of Health (NIH) Task Force on Research in Emergency Medicine was formed to enhance NIH support for emergency care research. Members of the NIH Task Force and academic leaders in emergency care participated in 3 Roundtable discussions to prioritize current opportunities for enhancing and conducting emergency care research. We identify key research questions essential to advancing the science of emergency care and discuss the barriers and strategies to advance research by exploring the collaboration between NIH and the emergency care community. Experts from emergency medicine, neurology, psychiatry, and public health assembled to review critical areas in need of investigation, current gaps in knowledge, barriers, and opportunities. Neurologic emergencies included cerebral resuscitation, pain, stroke, syncope, traumatic brain injury, and pregnancy. Mental health topics included suicide, agitation and delirium, substances, posttraumatic stress, violence, and bereavement. Presentations and group discussion firmly established the need for translational research to bring basic science concepts into the clinical arena. A coordinated continuum of the health care system that ensures rapid identification and stabilization and extends through discharge is necessary to maximize overall patient outcomes. There is a paucity of well-designed, focused research on diagnostic testing, clinical decisionmaking, and treatments in the emergency setting. Barriers include the limited number of experienced researchers in emergency medicine, limited dedicated research funding, and difficulties of conducting research in chaotic emergency environments stressed by crowding and limited resources. Several themes emerged during the course of the roundtable discussion, including the need for development of (1) a research infrastructure for the rapid identification, consent, and tracking of research subjects that incorporates innovative informatics technologies, essential for future research; (2) diagnostic strategies and tools necessary to understand key populations and the process of medical decisionmaking, including the investigation of the pathobiology of symptoms and symptom-oriented therapies; (3) collaborative research networks to provide unique opportunities to form partnerships, leverage patient cohorts and clinical and financial resources, and share data; (4) formal research training programs integral for creating new knowledge and advancing the science and practice of emergency medicine; and (5) recognition that emergency care is part of an integrated system from emergency medical services dispatch to discharge. The NIH Roundtable "Opportunities to Advance Research on Neurological and Psychiatric Emergencies" created a framework to guide future emergency medicine-based research initiatives. Emergency departments provide the portal of access to the health care system for most patients with acute neurologic and psychiatric illness. Emergency physicians and colleagues are primed to investigate neurologic and psychiatric emergencies that will directly improve the delivery of care and patient outcomes. Copyright © 2010. Published by Mosby, Inc.

AGRICULTURE IS MORE THAN FARMING, A LOOK AT OPPORTUNITIES AND EDUCATIONAL NEEDS.

ERIC Educational Resources Information Center

National Association of Agricultural Education Supervisors.

FARMING, INCLUDING RANCHING, IS AMERICA'S LARGEST AND MOST BASIC INDUSTRY. AGRICULTURE IS MORE THAN FARMING, INVOLVING MILLIONS OF PERSONS IN FARM-RELATED OCCUPATIONS WHO FURNISH SUPPLIES AND SERVICES TO FARMERS AND WHO MARKET, TRANSPORT, PROCESS, AND SELL FARM PRODUCED GOODS. OCCUPATIONAL OPPORTUNITIES FOR AGRICULTURALLY-TRAINED PERSONS EXTEND…

Teaching Health in a Natural History Museum.

ERIC Educational Resources Information Center

Newman, Ian M.

The opportunities offered by a natural history museum to enhance and expand classroom instruction in health are discussed. A basic constellation of typical natural history museum exhibit concepts and an array of health-related opportunities that are easily developed around these displays is outlined. The natural history concept provides an…

Emerging Applications of Liquid Crystals Based on Nanotechnology

PubMed Central

Sohn, Jung Inn; Hong, Woong-Ki; Choi, Su Seok; Coles, Harry J.; Welland, Mark E.; Cha, Seung Nam; Kim, Jong Min

2014-01-01

Diverse functionalities of liquid crystals (LCs) offer enormous opportunities for their potential use in advanced mobile and smart displays, as well as novel non-display applications. Here, we present snapshots of the research carried out on emerging applications of LCs ranging from electronics to holography and self-powered systems. In addition, we will show our recent results focused on the development of new LC applications, such as programmable transistors, a transparent and active-type two-dimensional optical array and self-powered display systems based on LCs, and will briefly discuss their novel concepts and basic operating principles. Our research will give insights not only into comprehensively understanding technical and scientific applications of LCs, but also developing new discoveries of other LC-based devices. PMID:28788555

California Basic Skills Initiative (BSI) Regional Networks as Self-Sustaining Communities of Practice

ERIC Educational Resources Information Center

Mullen, Adrienne Ann

2011-01-01

The Basic Skills Report for California Community Colleges (2007) stresses the importance of comprehensive training and development opportunities for all faculty (tenured and part-time), administrators and staff members who work with underprepared students. With such a large number of academically underprepared students entering the community…

A Survey of Basic Instructional Program Graduate Teaching Assistant Development and Support Processes

ERIC Educational Resources Information Center

Russell, Jared A.

2009-01-01

For over 100 years, basic instructional programs (BIP) have played a pivotal role in providing undergraduates with opportunities to acquire sport-related skills and conceptual knowledge relevant to promoting their involvement in lifelong physical activity and establishing healthy lifestyle habits. Critical to delivering this instructional content…

The Emerging Field of Human Social Genomics

PubMed Central

Slavich, George M.; Cole, Steven W.

2013-01-01

Although we generally experience our bodies as being biologically stable across time and situations, an emerging field of research is demonstrating that external social conditions, especially our subjective perceptions of those conditions, can influence our most basic internal biological processes—namely, the expression of our genes. This research on human social genomics has begun to identify the types of genes that are subject to social-environmental regulation, the neural and molecular mechanisms that mediate the effects of social processes on gene expression, and the genetic polymorphisms that moderate individual differences in genomic sensitivity to social context. The molecular models resulting from this research provide new opportunities for understanding how social and genetic factors interact to shape complex behavioral phenotypes and susceptibility to disease. This research also sheds new light on the evolution of the human genome and challenges the fundamental belief that our molecular makeup is relatively stable and impermeable to social-environmental influence. PMID:23853742

Space Rocks Tell Their Secrets: Space Science Applications of Physics and Chemistry for High School and College Classes: Update

NASA Technical Reports Server (NTRS)

Lindstrom, M. M.; Tobola, K. W.; Stocco, K.; Henry, M.; Allen, J. S.; McReynolds, Julie; Porter, T. Todd; Veile, Jeri

2004-01-01

As the scientific community studies Mars remotely for signs of life and uses Martian meteorites as its only available samples, teachers, students, and the general public continue to ask, How do we know these meteorites are from Mars? This question sets the stage for a six-lesson instructional package Space Rocks Tell Their Secrets. Expanding on the short answer It s the chemistry of the rock , students are introduced to the research that reveals the true identities of the rocks. Since few high school or beginning college students have the opportunity to participate in this level of research, a slide presentation introduces them to the labs, samples, and people involved with the research. As they work through the lessons and interpret authentic data, students realize that the research is an application of two basic science concepts taught in the classroom, the electromagnetic spectrum and isotopes.

Translational study of microRNAs and its application in kidney disease and hypertension research

PubMed Central

KRIEGEL, Alison J.; MLADINOV, Domagoj; LIANG, Mingyu

2015-01-01

MicroRNA research in humans and mammalian model organisms is in a crucial stage of development. Diagnostic and therapeutic values of microRNAs appear promising, but remain to be established. The physiological and pathophysiological significance of microRNAs is generally recognized, but much better understood in some organ systems and disease areas than others. In the present paper, we review several translational studies of microRNAs, including those showing the potential value of therapeutic agents targeting microRNAs and diagnostic or prognostic microRNA markers detectable in body fluids. We discuss the lessons learned and the experience gained from these studies. Several recent studies have begun to explore translational microRNA research in kidney disease and hypertension. Translational research of microRNAs in the kidney faces unique challenges, but provides many opportunities to develop and apply new methods, and to merge complementary basic and clinical approaches. PMID:22283365

Research information knowledge, perceived adequacy, and understanding in cancer clinical trial participants.

PubMed

Biedrzycki, Barbara A

2011-07-01

To describe the adequacy of research information among people with cancer at the time they accept or decline participation in a cancer clinical trial. Cross-sectional, descriptive. An urban, academic, National Cancer Institute-designated comprehensive cancer center. 197 patients with advanced gastrointestinal cancer. Mailed survey; self-reported data. Adequacy of research information (actual knowledge, perceived adequacy of information, and perceived understanding), cancer clinical trial participation, and satisfaction with the decision to participate. Most respondents (88%) perceived themselves as having adequate information to make an informed decision regarding cancer clinical trial participation. In addition, 35% demonstrated adequate knowledge of basic clinical research. Patients decide to accept or decline cancer clinical trials without having adequate knowledge. Nurses have an important role in educating patients regarding cancer clinical trials. The ideal teachable moment may not occur at the time of diagnosis; other less stressful opportunities may present when the patient is more receptive.

Morbidity management and disability prevention for lymphatic filariasis in Sri Lanka: Current status and future prospects

PubMed Central

Premaratna, Ranjan; Gunaratna, Indeewarie. E.; de Silva, Nilanthi R.

2018-01-01

Background Sri Lanka was acknowledged to have eliminated lymphatic filariasis (LF) as a public health problem in 2016, largely due to its success in Mass Drug Administration (MDA) to interrupt disease transmission. Analysis of the Strengths, Weaknesses, Opportunities and Threats (SWOT) of the national Morbidity Management and Disability Prevention (MMDP) program, the other pillar of the LF control program, was carried out with the objective of evaluating it and providing recommendations to optimize the use of available resources. Methodology A situation analysis of the MMDP activities provided by the state health sector was carried out using published records, in-depth interviews with key informants of the Anti Filariasis Campaign, site-visits to filariasis clinics with informal discussions with clinic workforce and personal communications to identify strengths and weaknesses; and opportunities to overcome weaknesses and perceived threats to the program were explored. The principal strength of the MMDP program was the filariasis clinics operational in most endemic districts of Sri Lanka, providing free health care and health education to clinic attendees. The weaknesses identified were the low accessibility of clinics, incomplete coverage of the endemic region and lack of facilities for rehabilitation. The perceived threats were diversion of staff and resources for control of other vector-borne infections, under-utilization of clinics and non-compliance with recommended treatment. Enhanced high level commitment for MMDP, wider publicity and referral systems, integration of MMDP with other disease management services and collaboration with welfare organizations and research groups were identified as opportunities to overcome weaknesses and challenges. Conclusions The recommended basic package of MMDP was functional in most of the LF-endemic region. The highlighted weaknesses and challenges, unless addressed, may threaten program sustainability. The identified opportunities for improvement of the programme could ensure better attainment of the goal of the MMDP program, namely access to basic care for all affected by lymphatic filarial disease. PMID:29746479

Morbidity management and disability prevention for lymphatic filariasis in Sri Lanka: Current status and future prospects.

PubMed

Chandrasena, Nilmini; Premaratna, Ranjan; Gunaratna, Indeewarie E; de Silva, Nilanthi R

2018-05-01

Sri Lanka was acknowledged to have eliminated lymphatic filariasis (LF) as a public health problem in 2016, largely due to its success in Mass Drug Administration (MDA) to interrupt disease transmission. Analysis of the Strengths, Weaknesses, Opportunities and Threats (SWOT) of the national Morbidity Management and Disability Prevention (MMDP) program, the other pillar of the LF control program, was carried out with the objective of evaluating it and providing recommendations to optimize the use of available resources. A situation analysis of the MMDP activities provided by the state health sector was carried out using published records, in-depth interviews with key informants of the Anti Filariasis Campaign, site-visits to filariasis clinics with informal discussions with clinic workforce and personal communications to identify strengths and weaknesses; and opportunities to overcome weaknesses and perceived threats to the program were explored. The principal strength of the MMDP program was the filariasis clinics operational in most endemic districts of Sri Lanka, providing free health care and health education to clinic attendees. The weaknesses identified were the low accessibility of clinics, incomplete coverage of the endemic region and lack of facilities for rehabilitation. The perceived threats were diversion of staff and resources for control of other vector-borne infections, under-utilization of clinics and non-compliance with recommended treatment. Enhanced high level commitment for MMDP, wider publicity and referral systems, integration of MMDP with other disease management services and collaboration with welfare organizations and research groups were identified as opportunities to overcome weaknesses and challenges. The recommended basic package of MMDP was functional in most of the LF-endemic region. The highlighted weaknesses and challenges, unless addressed, may threaten program sustainability. The identified opportunities for improvement of the programme could ensure better attainment of the goal of the MMDP program, namely access to basic care for all affected by lymphatic filarial disease.

Mixed methods research in music therapy research.

PubMed

Bradt, Joke; Burns, Debra S; Creswell, John W

2013-01-01

Music therapists have an ethical and professional responsibility to provide the highest quality care possible to their patients. Much of the time, high quality care is guided by evidence-based practice standards that integrate the most current, available research in making decisions. Accordingly, music therapists need research that integrates multiple ways of knowing and forms of evidence. Mixed methods research holds great promise for facilitating such integration. At this time, there have not been any methodological articles published on mixed methods research in music therapy. The purpose of this article is to introduce mixed methods research as an approach to address research questions relevant to music therapy practice. This article describes the core characteristics of mixed methods research, considers paradigmatic issues related to this research approach, articulates major challenges in conducting mixed methods research, illustrates four basic designs, and provides criteria for evaluating the quality of mixed methods articles using examples of mixed methods research from the music therapy literature. Mixed methods research offers unique opportunities for strengthening the evidence base in music therapy. Recommendations are provided to ensure rigorous implementation of this research approach.

A survey of application: genomics and genetic programming, a new frontier.

PubMed

Khan, Mohammad Wahab; Alam, Mansaf

2012-08-01

The aim of this paper is to provide an introduction to the rapidly developing field of genetic programming (GP). Particular emphasis is placed on the application of GP to genomics. First, the basic methodology of GP is introduced. This is followed by a review of applications in the areas of gene network inference, gene expression data analysis, SNP analysis, epistasis analysis and gene annotation. Finally this paper concluded by suggesting potential avenues of possible future research on genetic programming, opportunities to extend the technique, and areas for possible practical applications. Copyright © 2012 Elsevier Inc. All rights reserved.

Human Factors and the International Space Station

NASA Technical Reports Server (NTRS)

Peacock, Brian; Rajulu, Sudhakar; Novak, Jennifer; Rathjen, Thomas; Whitmore, Mihriban; Maida, James; Woolford, Barbara

2001-01-01

The purposes of this panel are to inform the human factors community regarding the challenges of designing the International Space Station (ISS) and to stimulate the broader human factors community into participating in the various basic and applied research opportunities associated with the ISS. This panel describes the variety of techniques used to plan and evaluate human factors for living and working in space. The panel members have contributed to many different aspects of the ISS design and operations. Architecture, equipment, and human physical performance requirements for various tasks have all been tailored to the requirements of operating in microgravity.

Machine Learning, deep learning and optimization in computer vision

NASA Astrophysics Data System (ADS)

Canu, Stéphane

2017-03-01

As quoted in the Large Scale Computer Vision Systems NIPS workshop, computer vision is a mature field with a long tradition of research, but recent advances in machine learning, deep learning, representation learning and optimization have provided models with new capabilities to better understand visual content. The presentation will go through these new developments in machine learning covering basic motivations, ideas, models and optimization in deep learning for computer vision, identifying challenges and opportunities. It will focus on issues related with large scale learning that is: high dimensional features, large variety of visual classes, and large number of examples.

The Resilience of Women in Higher Education in Afghanistan. Study No 1: Obstacles and Opportunities in Women's Enrollment and Graduation; Study No. 2: The Human, Social and Institutional Resilience of Female Doctors and Postgraduate Residency Programs. Resilience in Education Settings (RES)-Research Studies Series

ERIC Educational Resources Information Center

Kosha, Afifa; Oriya, Spozhmay; Nabi, Tahira; Halim, Sabera; Hofyani, Sohaila; Liwal, Abida; Safi, Najibullah; Sahak, Mohamad Nadir; Noormal, Bashir

2014-01-01

Female access to higher education in Afghanistan has been and continues to be limited. At the basic education level, the country has made great advances since 2000; it increased access from 900,000 students in 2000, almost all boys, to 6.7 million students in 2009, and girl's enrollment increased from 5,000 under the Taliban to 2.4 million in the…

Accounting for reciprocal host-microbiome interactions in experimental science.

PubMed

Stappenbeck, Thaddeus S; Virgin, Herbert W

2016-06-09

Mammals are defined by their metagenome, a combination of host and microbiome genes. This knowledge presents opportunities to further basic biology with translation to human diseases. However, the now-documented influence of the metagenome on experimental results and the reproducibility of in vivo mammalian models present new challenges. Here we provide the scientific basis for calling on all investigators, editors and funding agencies to embrace changes that will enhance reproducible and interpretable experiments by accounting for metagenomic effects. Implementation of new reporting and experimental design principles will improve experimental work, speed discovery and translation, and properly use substantial investments in biomedical research.

NASA Office of Aeronautical and Space Technology Summer Workshop. Volume 7: Materials panel

NASA Technical Reports Server (NTRS)

1975-01-01

Materials technology requirements pertinent to structures, power, and propulsion for future space missions are identified along with candidate space flight experiments. Most requirements are mission driven, only four (all relating to space processing of materials) are considered to be opportunity driven. Exploitation of the space environment in performing basic research to improve the understanding of materials phenomena (such as solidification) and manufacturing and assembly in space to support missions such as solar energy stations which require the forming, erection, joining, and repair of structures in space are among the topics discussed.

Decade of the Brain 1990--2000: Maximizing human potential

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1991-04-01

The US Decade of the Brain offers scientists throughout the Federal Government a unique opportunity to advance and apply scientific knowledge about the brain and nervous system. During the next 10 years, scientists hope to maximize human potential through studies of human behavior, senses and communication, learning and memory, genetic/chemical alterations, and environmental interactions. Progress in these areas should lead to reductions in mortality from brain and nervous system disorders and to improvements in the quality of life. This report identifies nine research areas that could form the basis of an integrated program in the brain and behavioral sciences. Amore » chart summarizing the Federal activities in these nine areas may be found at the back of the report. In addition, three areas that span the nine research areas -- basic research, technology and international activities -- are considered.« less

Biomedical research, a tool to address the health issues that affect African populations

PubMed Central

2013-01-01

Traditionally, biomedical research endeavors in low to middle resources countries have focused on communicable diseases. However, data collected over the past 20 years by the World Health Organization (WHO) show a significant increase in the number of people suffering from non-communicable diseases (e.g. heart disease, diabetes, cancer and pulmonary diseases). Within the coming years, WHO predicts significant decreases in communicable diseases while non-communicable diseases are expected to double in low and middle income countries in sub-Saharan Africa. The predicted increase in the non-communicable diseases population could be economically burdensome for the basic healthcare infrastructure of countries that lack resources to address this emerging disease burden. Biomedical research could stimulate development of healthcare and biomedical infrastructure. If this development is sustainable, it provides an opportunity to alleviate the burden of both communicable and non-communicable diseases through diagnosis, prevention and treatment. In this paper, we discuss how research using biomedical technology, especially genomics, has produced data that enhances the understanding and treatment of both communicable and non-communicable diseases in sub-Saharan Africa. We further discuss how scientific development can provide opportunities to pursue research areas responsive to the African populations. We limit our discussion to biomedical research in the areas of genomics due to its substantial impact on the scientific community in recent years however, we also recognize that targeted investments in other scientific disciplines could also foster further development in African countries. PMID:24143865

Education programs of the Institute for Optical Sciences at the University of Toronto

NASA Astrophysics Data System (ADS)

Istrate, Emanuel; Miller, R. J. Dwayne

2009-06-01

The Institute for Optical Sciences at the University of Toronto is an association of faculty members from various departments with research interests in optics. The institute has an extensive program of academic activities, for graduate and undergraduate students, as well as public outreach. For undergraduate students, we have a course on holography. We provide opportunities for students to gain optics experience through research by providing access to summer research positions and by enrolling them in the Research Skills Program, a summer course teaching the basic skills needed in research. For graduate students, we offer the Distinguished Visiting Scientists program, where world-renowned researchers come for a week, giving a series of 3 lectures and interacting closely with students and professors. The extended stay allows the program to run like a mini-course. We launched a Collaborative Master's Program in Optics, where students earn a degree from their home department, along with a certification of participation in the collaborative program. Physics, Chemistry and Engineering students attending together are exposed to the various points of view on optics, ranging from the pure to the applied sciences. For the general public, we offer the Stoicheff Lecture, a yearly public lecture on optics, organized with the Royal Canadian Institute. Our institute also initiated Science Rendezvous, a yearly public celebration of science across the Greater Toronto Area, with lab tours, demonstrations, and other opportunities to learn about science and those who are actively advancing it. This year, this event attracted over 20,000 attendees.

Application of the Recreation Opportunity Spectrum for Outdoor Recreation Planning on Army Installations.

DTIC Science & Technology

1982-03-01

to preference types, and uses capacity estimation; therefore, it is basically a good system for recreation and resource inventory and classification...quan- tity, and distribution of recreational resources. Its basic unit of inventory is landform, or the homogeneity of physical features used to...by Clark and Stankey, "the basic assumption underlying the ROS is that quality recreational experiences are best assured by providing a diverse set of

Geropsychology training in a specialist geropsychology doctoral program.

PubMed

Qualls, Sara Honn; Segal, Daniel L; Benight, Charles C; Kenny, Michael P

2005-01-01

The first PhD specialty program in Geropsychology that launched in fall, 2004 at CU-Colorado Springs is described. Consistent with a scientist-practitioner model, the curriculum sequence builds systematically from basic to complex knowledge and skills across the domains of scientific psychology, research methodology, general clinical, geropsychology science, and clinical geropsychology. Practicum experiences also build skills in core clinical competencies needed by geropsychologists, including assessment, psychotherapy, neuropsychological evaluations, caregiver consultation and counseling, health psychology, and outreach/prevention. Research mentoring prepares students with the skills needed to conduct independent research useful to the clinical practice of geropsychology. Challenges faced in the process of developing the program include the development of a training clinic, balancing specialty and generalized training, building a specialty culture while maintaining faculty integration, attracting faculty and students during a start-up phase, and defining an identity within the field. The mental health services center that was launched to meet training needs while addressing a services niche in the community contributes substantially to the essence of this program, and is described in some detail. Future opportunities and challenges include program funding, heavy demands of specialty training on top of generalist training, maintaining congruence between expectations of clinical and non-clinical faculty, providing interdisciplinary experience, and expansion of practicum opportunities.

How to Design a Genetic Mating Scheme: A Basic Training Package for Drosophila Genetics

PubMed Central

Roote, John; Prokop, Andreas

2013-01-01

Drosophila melanogaster is a powerful model organism for biological research. The essential and common instrument of fly research is genetics, the art of applying Mendelian rules in the specific context of Drosophila with its unique classical genetic tools and the breadth of modern genetic tools and strategies brought in by molecular biology, transgenic technologies and the use of recombinases. Training newcomers to fly genetics is a complex and time-consuming task but too important to be left to chance. Surprisingly, suitable training resources for beginners currently are not available. Here we provide a training package for basic Drosophila genetics, designed to ensure that basic knowledge on all key areas is covered while reducing the time invested by trainers. First, a manual introduces to fly history, rationale for mating schemes, fly handling, Mendelian rules in fly, markers and balancers, mating scheme design, and transgenic technologies. Its self-study is followed by a practical training session on gender and marker selection, introducing real flies under the dissecting microscope. Next, through self-study of a PowerPoint presentation, trainees are guided step-by-step through a mating scheme. Finally, to consolidate knowledge, trainees are asked to design similar mating schemes reflecting routine tasks in a fly laboratory. This exercise requires individual feedback but also provides unique opportunities for trainers to spot weaknesses and strengths of each trainee and take remedial action. This training package is being successfully applied at the Manchester fly facility and may serve as a model for further training resources covering other aspects of fly research. PMID:23390611

Fueling Chemical Engineering Concepts with Biodiesel Production: A Professional Development Experience for High School Pre-Service Teachers

ERIC Educational Resources Information Center

Gupta, Anju

2015-01-01

This one-day workshop for pre-service teachers was aimed at implementing a uniquely designed and ready-to-implement chemical engineering curriculum in high school coursework. This educational and professional development opportunity introduced: 1) chemical engineering curriculum and career opportunities, 2) basic industrial processes and flow…

Orientation, Shop Tools and Equipment; Appliance Repair--Basic: 9023.01.

ERIC Educational Resources Information Center

Dade County Public Schools, Miami, FL.

Presented as an introduction to appliance repair, the course is intended as an orientation in the duties, responsibilities, and career opportunities of the major appliances service technician. It also introduces the learner to the various types of tools and equipment used in this trade, and provides him an opportunity for instruction and practice…

Opportunity Knocked Out: Reducing Cheating by Teachers on Student Tests.

ERIC Educational Resources Information Center

Ligon, Glynn

Careful management of a testing program can greatly limit a teacher's opportunity to cheat while administering standardized tests to students and can increase the likelihood that such cheating will be detected. The Austin Independent School District's systemwide testing staff's plan for controlling cheating has three basic premises: (1) plan and…

Alternate Jobs for Aerospace Workers. Examples of Civil Service Employment Opportunities.

ERIC Educational Resources Information Center

Draper, A. M. Leslie

Based on a survey of the characteristics of unemployed aerospace workers, this is the first of two reports developed to suggest alternate job opportunities in government agencies for unemployed aerospace engineers and scientists. Included in the brief summaries of 70 government job titles are general, basic qualifications and the government agency…

State of Maine Student Financial Aid Guide to Post-Secondary Education. 1979-1980.

ERIC Educational Resources Information Center

Maine State Post-Secondary Education Commission, Augusta.

Financial aid information for residents of the State of Maine is presented in this booklet. Instructions for completing the College Scholarship Service Financial Aid Form are presented. The Basic Educational Opportunity Grants Program, the Supplemental Educational Opportunity Grant Program, Maine State Incentive Scholarship Program, and the New…

Building Integrated Pathways to Sustainable Careers: An Introduction to the Accelerated Opportunity Initiative

ERIC Educational Resources Information Center

Pleasants, Rachel

2011-01-01

"Accelerating Opportunity" responds to the nation's growing need for improved pathways from Adult Basic Education (ABE) to credentials of value in the labor market. It builds on promising practices developed in "Breaking Through," an initiative of Jobs for the Future and the National Council for Workforce Education, and…

Proposal for research and education: joint lectures and practicals on central nervous system anatomy and physiology.

PubMed

Kageyama, Ikuo; Yoshimura, Ken; Satoh, Yoshihide; Nanayakkara, Chinthani D; Pallegama, Ranjith W; Iwasaki, Shin-Ichi

2016-07-01

We coordinated anatomy and physiology lectures and practicals to facilitate an integrated understanding of morphology and function in a basic medical science program for dental students and to reduce the time spent on basic science education. This method is a means to provide the essential information and skills in less time. The overall impression was that the practice of joint central nervous system lectures and practicals was an efficient method for students, which suggests that joint lectures might also be useful for clinical subjects. About two-thirds of students felt that the joint anatomy and physiology lecture on the central nervous system was useful and necessary in understanding the relationship between morphology and function, at least for this subject. One-third of students were neutral on the effectiveness of this method. However, the survey results suggest that improvements are needed in the method and timing of joint lectures and practicals. The present teaching approach can be further improved by conducting combined lectures in which the form and function of anatomic structures are presented by the relevant departments during the same lecture. Finally, joint lecturers and practicals offer an opportunity to increase student understanding of the importance of new research findings by the present authors and other researchers.

Genome resource banking for wildlife research, management, and conservation.

PubMed

Wildt, D E

2000-01-01

Cryobiology offers an important opportunity to assist in the management and study of wildlife, including endangered species. The benefits of developing genome resource banks for wildlife are profound, perhaps more so than for traditional uses in terms of livestock and human fertility. In addition to preserving heterozygosity and assisting in the genetic management of rare populations held in captivity, frozen repositories help insure wild populations against natural and human-induced catastrophes. Such banks also are an invaluable source of new knowledge (for basic and applied research) from thousands of species that have yet to be studied. However, it is crucial that genome resource banks for wildlife species be developed in a coordinated fashion that first benefits the conservation of biodiversity. Spurious collections will be of no advantage to genuine conservation. The Conservation Breeding Specialist Group (CBSG; of the International Union for the Conservation of Nature and Natural Resources' Species Survival Commission) has promoted international dialogue on this topic. CBSG working groups have recognized that such repositories be developed according to specific, scientific guidelines consistent with an international standard that ensures practicality, high-quality ethics, and cost-effectiveness. Areas requiring priority attention also are reviewed, including the need for more basic research, advocacy, and support for developing organized repositories of biomaterials representing the world's diverse biota.

Project BEST-PAL (Basic Education Skills Through-Parenting Affective Learning): Level I Modules.

ERIC Educational Resources Information Center

Brevard Community Coll., Cocoa, FL.

These eight learning modules were prepared for parents participating in Brevard Community College's Project BEST-PAL (Basic Education Skills Through-Parenting Affective Learning), which was designed for low socioeconomic parents who are in need of an opportunity to explore effective parenting. First, materials for the BEST-PAL volunteer sponsors…

Project BEST-PAL (Basic Education Skills Through-Parenting Affective Learning): Level II Modules.

ERIC Educational Resources Information Center

Brevard Community Coll., Cocoa, FL.

These eight learning modules were prepared for parents participating in Brevard Community College's Project BEST-PAL (Basic Education Skills Through-Parenting Affective Learning), which was designed for low socioeconomic parents who are in need of an opportunity to explore effective parenting. First, materials for the BEST-PAL volunteer sponsors…

Project BEST-PAL (Basic Education Skills Through-Parenting Affective Learning): Volunteer Sponsor's Leader's Guide.

ERIC Educational Resources Information Center

Brevard Community Coll., Cocoa, FL.

This handbook was developed for volunteer group leaders participating in Brevard Community College's Project BEST-PAL (Basic Education Skills Through-Parenting Affective Learning). Project BEST-PAL was developed especially for low socioeconomic parents who are in need of an opportunity to explore effective parenting, with a primary objective being…

Development and Optimisation of an In-Service Teacher Training Programme on Motivational Assessment in Physical Education

ERIC Educational Resources Information Center

Slingerland, Menno; Borghouts, Lars; Jans, Liesbeth; Weeldenburg, Gwen; van Dokkum, Gertjan; Vos, Steven; Haerens, Leen

2017-01-01

Although assessment practices are commonly part of the physical education (PE) curriculum they may often frustrate rather than support students' basic needs for autonomy, competence and relatedness. Nevertheless, assessment also provides various promising opportunities to support these basic needs and enhance learning in students. In order to…

The Risks and Opportunities Associated with Weak Arithmatic Skills of Accounting Students

ERIC Educational Resources Information Center

Kerr, Stephen; Krull, George

2017-01-01

This paper explored the authors' concerns about students enrolled in their introductory accounting course. Anecdotal evidence suggested that students struggle with basic arithmetic concepts that underlie basic business transactions even though their math placement and ACT scores are high. A survey of 125 students in a first accounting course was…

Basic Hemorheology Advan Physiology Ed v37 n2 p129-134 Usingclassic.pdfC

ERIC Educational Resources Information Center

Toksvang, Linea Natalie; Berg, Ronan M.G.

2013-01-01

"The viscosity of the blood in narrow capillary tubes" by Robin Fahraeus and Torsten Lindqvist ("Am J Physiol" 96: 562--568, 1931) can be a valuable opportunity for teaching basic hemorheological principles in undergraduate cardiovascular physiology. This classic paper demonstrates that a progressive decline in apparent…

Quality in the Basic Grant Delivery System: Volume 1, Findings.

ERIC Educational Resources Information Center

Advanced Technology, Inc., McLean, VA.

Detailed findings from the first stage of the Basic Educational Opportunity Grant (BEOG) quality control project are presented. For the 4,500 students selected as representative of the BEOG, or Pell Grant, recipient population as of Fall 1980, data were collected from: federal tax returns, interviews with student recipients and their parents, tax…

Zero Income Basic Grant Applicants. Phase II Report.

ERIC Educational Resources Information Center

Applied Management Sciences, Inc., Silver Spring, MD.

The nature and extent of corrections made to their records by zero/low income applicants to the Basic Educational Opportunity Grant (BEOG) program was investigated. Behaviors of zero/low income applicants and the total pool of applicants were also compared. It was found that zero/low income applicants and all applicants who were rejected displayed…

Exercise Self-Efficacy and Perceived Wellness among College Students in a Basic Studies Course

ERIC Educational Resources Information Center

Sidman, Cara L.; D'Abundo, Michelle Lee; Hritz, Nancy

2009-01-01

University basic studies courses provide a valuable opportunity for facilitating the knowledge, skills, and beliefs that develop healthy behaviors to last a lifetime. Belief in one's ability to participate in physical activity, exercise self-efficacy, is a psychological construct that has had a documented impact on physical activity. Although…

The Changing Fabric of Adult Basic Education in Kansas

ERIC Educational Resources Information Center

Zacharakis, Jeff

2007-01-01

This article discusses the changing cultural fabric in Kansas. The author sees this change as an opportunity to strengthen and expand the Adult Basic Education and English as a Second Language programming. By taking this approach, adult education will appeal not only to best practices where authentic community-based approaches are indeed more…

Training and career development in clinical and translational science: an opportunity for rehabilitation scientists.

PubMed

Kelly, Thomas H; Mattacola, Carl G

2010-11-01

The National Institutes of Health's Clinical and Translational Science Award initiative is designed to establish and promote academic centers of clinical and translational science (CTS) that are empowered to train and advance multi- and interdisciplinary investigators and research teams to apply new scientific knowledge and techniques to enhance patient care. Among the key components of a full-service center for CTS is an educational platform to support research training in CTS. Educational objectives and resources available to support the career development of the clinical and translational scientists, including clinical research education, mentored research training, and career development support, are described. The purpose of the article is to provide an overview of the CTS educational model so that rehabilitation specialists can become more aware of potential resources that are available and become more involved in the delivery and initiation of the CTS model in their own workplace. Rehabilitation clinicians and scientists are well positioned to play important leadership roles in advancing the academic mission of CTS. Rigorous academic training in rehabilitation science serves as an effective foundation for supporting the translation of basic scientific discovery into improved health care. Rehabilitation professionals are immersed in patient care, familiar with interdisciplinary health care delivery, and skilled at working with multiple health care professionals. The NIH Clinical and Translational Science Award initiative is an excellent opportunity to advance the academic development of rehabilitation scientists.

A research education program model to prepare a highly qualified workforce in biomedical and health-related research and increase diversity.

PubMed

Crockett, Elahé T

2014-09-24

The National Institutes of Health has recognized a compelling need to train highly qualified individuals and promote diversity in the biomedical/clinical sciences research workforce. In response, we have developed a research-training program known as REPID (Research Education Program to Increase Diversity among Health Researchers) to prepare students/learners to pursue research careers in these fields and address the lack of diversity and health disparities. By inclusion of students/learners from minority and diverse backgrounds, the REPID program aims to provide a research training and enrichment experience through team mentoring to inspire students/learners to pursue research careers in biomedical and health-related fields. Students/learners are recruited from the University campus from a diverse population of undergraduates, graduates, health professionals, and lifelong learners. Our recruits first enroll into an innovative on-line introductory course in Basics and Methods in Biomedical Research that uses a laboratory Tool-Kit (a lab in a box called the My Dr. ET Lab Tool-Kit) to receive the standard basics of research education, e.g., research skills, and lab techniques. The students/learners will also learn about the responsible conduct of research, research concept/design, data recording/analysis, and scientific writing/presentation. The course is followed by a 12-week hands-on research experience during the summer. The students/learners also attend workshops and seminars/conferences. The students/learners receive scholarship to cover stipends, research related expenses, and to attend a scientific conference. The scholarship allows the students/learners to gain knowledge and seize opportunities in biomedical and health-related careers. This is an ongoing program, and during the first three years of the program, fifty-one (51) students/learners have been recruited. Thirty-six (36) have completed their research training, and eighty percent (80%) of them have continued their research experiences beyond the program. The combination of carefully providing standard basics of research education and mentorship has been successful and instrumental for training these students/learners and their success in finding biomedical/health-related jobs and/or pursuing graduate/medical studies. All experiences have been positive and highly promoted. This approach has the potential to train a highly qualified workforce, change lives, enhance biomedical research, and by extension, improve national health-care.

Earth System Science Education Interdisciplinary Partnerships

NASA Astrophysics Data System (ADS)

Ruzek, M.; Johnson, D. R.

2002-05-01

Earth system science in the classroom is the fertile crucible linking science with societal needs for local, national and global sustainability. The interdisciplinary dimension requires fruitful cooperation among departments, schools and colleges within universities and among the universities and the nation's laboratories and agencies. Teaching and learning requires content which brings together the basic and applied sciences with mathematics and technology in addressing societal challenges of the coming decades. Over the past decade remarkable advances have emerged in information technology, from high bandwidth Internet connectivity to raw computing and visualization power. These advances which have wrought revolutionary capabilities and resources are transforming teaching and learning in the classroom. With the launching of NASA's Earth Observing System (EOS) the amount and type of geophysical data to monitor the Earth and its climate are increasing dramatically. The challenge remains, however, for skilled scientists and educators to interpret this information based upon sound scientific perspectives and utilize it in the classroom. With an increasing emphasis on the application of data gathered, and the use of the new technologies for practical benefit in the lives of ordinary citizens, there comes the even more basic need for understanding the fundamental state, dynamics, and complex interdependencies of the Earth system in mapping valid and relevant paths to sustainability. Technology and data in combination with the need to understand Earth system processes and phenomena offer opportunities for new and productive partnerships between researchers and educators to advance the fundamental science of the Earth system and in turn through discovery excite students at all levels in the classroom. This presentation will discuss interdisciplinary partnership opportunities for educators and researchers at the undergraduate and graduate levels.

Research as a standard of care in PICU

PubMed Central

Zimmerman, Jerry J.; Anand, Kanwaljeet J. S.; Meert, Kathleen L.; Willson, Douglas F.; Newth, Christopher J. L.; Harrison, Rick; Carcillo, Joseph A.; Berger, John; Jenkins, Tammara L.; Nicholson, Carol; Dean, J. Michael

2016-01-01

Background Excellence in clinical care coupled with basic and applied research reflects the maturation of a medical subspecialty, advances that field, and provides objective data for identifying best practices. Pediatric intensive care units (PICU) are uniquely suited for conducting translational and clinical research. Moreover, multiple investigations have reported that a majority of parents are interested in their children’s participation in clinical research, even when the research offers no direct benefit to their child. However, such activity may generate ethical conflict with bedside care providers trying to acutely identify the best approach for an individual critically ill child. Ultimately, this conflict may diminish enthusiasm for the generation of scientific evidence that supports application of evidence-based medicine into PICU clinical standard work. Objective Provide an overview of current state PICU clinical research strengths, liabilities, opportunities, and barriers, and contrast this with an established pediatric hematology-oncology iterative research model that constitutes a learning healthcare system. Design Narrative review of medical literature published in English. Conclusions Currently most PICU therapy is not evidence-based. Developing a learning healthcare system in the PICU integrates clinical research into usual practice and fosters a culture of evidence-based learning and continual care improvement. As PICU mortality has significantly decreased, identification and validation of patient-centered, clinically relevant research outcome measures other than mortality is essential for future clinical trial design. Because most pediatric critical illness may be classified as rare diseases, participation in research networks will facilitate iterative, collaborative, multi-institutional investigations that over time identify best practices to improve PICU outcomes. Despite real ethical challenges, critically ill children and their families should have the opportunity to participate in translational/clinical research whenever feasible. PMID:26513203

Current status of integrating information technologies into the clinical research enterprise within US academic health centers: strategic value and opportunities for investment.

PubMed

Turisco, Fran; Keogh, Diane; Stubbs, Connie; Glaser, John; Crowley, William F

2005-12-01

Little information exists about the incorporation of information technologies (ITs) into clinical research processes within US academic health centers (AHCs). Therefore, we queried a group of 37 leading AHCs regarding their current status and future plans in clinical research IT. The survey specifically inquired about the presence or absence of basic infrastructure and IT support requirements; individual applications needed to support study preparation, study conduct, and its administrative support; and integration of data from basic research, clinical trials, and the clinical information systems increasingly used in health care delivery. Of the 37 AHCs, 78% responded. All strongly agreed that a "state-of-the-art" clinical research IT program would be ideal today and will be essential tomorrow. Nonetheless, no AHC currently has an IT solution that even approached this ideal. No AHC reported having all of the essential management foundations (ie, a coherent vision, an overall strategy, a governance structure, and a dedicated budget) necessary to launch and sustain a truly successful implementation of a cohesive clinical research IT platform. Many had achieved breakthroughs in individual aspects of clinical research IT, for example, adverse event reporting systems or consent form templates. However, overall implementation of IT to support clinical research is uneven and insufficient. These data document a substantial gap in clinical research IT investments in leading US AHCs. Linking the clinical research IT enterprise with its clinical operations in a meaningful fashion remains a crucial strategic goal of AHCs. If they are to continue to serve as the "translational research engines" that our society expects, AHCs must recognize this gap and allocate substantial resource deployment to remedying this situation.

Medical research and audit skills training for undergraduates: an international analysis and student-focused needs assessment.

PubMed

2018-01-01

Interpreting, performing and applying research is a key part of evidence-based medical practice, however, incorporating these within curricula is challenging. This study aimed to explore current provision of research skills training within medical school curricula, provide a student-focused needs assessment and prioritise research competencies. A international, cross-sectional survey of final year UK and Irish medical students was disseminated at each participating university. The questionnaire investigated research experience, and confidence in the Medical Education in Europe (MEDINE) 2 consensus survey research competencies. Fully completed responses were received from 521 final year medical students from 32 medical schools (43.4% male, mean age 24.3 years). Of these, 55.3% had an additional academic qualification (49.5% Bachelor's degree), and 38.8% had been a named author on an academic publication. Considering audit and research opportunities and teaching experience, 47.2% reported no formal audit training compared with 27.1% who reported no formal research training. As part of their medical school course, 53.4% had not performed an audit, compared with 29.9% who had not participated in any clinical or basic science research. Nearly a quarter of those who had participated in research reported doing so outside of their medical degree course. Low confidence areas included selecting and performing the appropriate statistical test, selecting the appropriate research method, and critical appraisal. Following adjustment, several factors were associated with increased confidence including previous clinical research experience (OR 4.21, 2.66 to 6.81, P<0.001), additional degrees (OR 2.34, 1.47 to 3.75, P<0.001), and male gender (OR 1.90, 1.25 to 2.09, P=0.003). Factors associated with an increase in perceived opportunities included formal research training in the curriculum (OR 1.66, 1.12 to 2.46, P=0.012), audit skills training in the curriculum (OR 1.52, 1.03 to 2.26, P= 0.036) and research methods taught in a student selected component (OR 1.75, 1.21 to 2.54, P=0.003). Nearly one-third of students lacked formal training on undertaking research, and half of students lacked formal audit training and opportunities to undertake audit as part of their medical school course. The presence of research training in the cirriculum was associated with an increase in perceived opportunities to participate in MEDINE2 research competencies. Female gender and a lack of previous research experience were significant factors influencing confidence and participation in research. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Basic Research Needs for Advanced Nuclear Systems. Report of the Basic Energy Sciences Workshop on Basic Research Needs for Advanced Nuclear Energy Systems, July 31-August 3, 2006

DOE Office of Scientific and Technical Information (OSTI.GOV)

Roberto, J.; Diaz de la Rubia, T.; Gibala, R.

2006-10-01

The global utilization of nuclear energy has come a long way from its humble beginnings in the first sustained nuclear reaction at the University of Chicago in 1942. Today, there are over 440 nuclear reactors in 31 countries producing approximately 16% of the electrical energy used worldwide. In the United States, 104 nuclear reactors currently provide 19% of electrical energy used nationally. The International Atomic Energy Agency projects significant growth in the utilization of nuclear power over the next several decades due to increasing demand for energy and environmental concerns related to emissions from fossil plants. There are 28 newmore » nuclear plants currently under construction including 10 in China, 8 in India, and 4 in Russia. In the United States, there have been notifications to the Nuclear Regulatory Commission of intentions to apply for combined construction and operating licenses for 27 new units over the next decade. The projected growth in nuclear power has focused increasing attention on issues related to the permanent disposal of nuclear waste, the proliferation of nuclear weapons technologies and materials, and the sustainability of a once-through nuclear fuel cycle. In addition, the effective utilization of nuclear power will require continued improvements in nuclear technology, particularly related to safety and efficiency. In all of these areas, the performance of materials and chemical processes under extreme conditions is a limiting factor. The related basic research challenges represent some of the most demanding tests of our fundamental understanding of materials science and chemistry, and they provide significant opportunities for advancing basic science with broad impacts for nuclear reactor materials, fuels, waste forms, and separations techniques. Of particular importance is the role that new nanoscale characterization and computational tools can play in addressing these challenges. These tools, which include DOE synchrotron X-ray sources, neutron sources, nanoscale science research centers, and supercomputers, offer the opportunity to transform and accelerate the fundamental materials and chemical sciences that underpin technology development for advanced nuclear energy systems. The fundamental challenge is to understand and control chemical and physical phenomena in multi-component systems from femto-seconds to millennia, at temperatures to 1000?C, and for radiation doses to hundreds of displacements per atom (dpa). This is a scientific challenge of enormous proportions, with broad implications in the materials science and chemistry of complex systems. New understanding is required for microstructural evolution and phase stability under relevant chemical and physical conditions, chemistry and structural evolution at interfaces, chemical behavior of actinide and fission-product solutions, and nuclear and thermomechanical phenomena in fuels and waste forms. First-principles approaches are needed to describe f-electron systems, design molecules for separations, and explain materials failure mechanisms. Nanoscale synthesis and characterization methods are needed to understand and design materials and interfaces with radiation, temperature, and corrosion resistance. Dynamical measurements are required to understand fundamental physical and chemical phenomena. New multiscale approaches are needed to integrate this knowledge into accurate models of relevant phenomena and complex systems across multiple length and time scales.« less

Preparing medical students for future learning using basic science instruction.

PubMed

Mylopoulos, Maria; Woods, Nicole

2014-07-01

The construct of 'preparation for future learning' (PFL) is understood as the ability to learn new information from available resources, relate new learning to past experiences and demonstrate innovation and flexibility in problem solving. Preparation for future learning has been proposed as a key competence of adaptive expertise. There is a need for educators to ensure that opportunities are provided for students to develop PFL ability and that assessments accurately measure the development of this form of competence. The objective of this research was to compare the relative impacts of basic science instruction and clinically focused instruction on performance on a PFL assessment (PFLA). This study employed a 'double transfer' design. Fifty-one pre-clerkship students were randomly assigned to either basic science instruction or clinically focused instruction to learn four categories of disease. After completing an initial assessment on the learned material, all participants received clinically focused instruction for four novel diseases and completed a PFLA. The data from the initial assessment and the PFLA were submitted to independent-sample t-tests. Mean ± standard deviation [SD] scores on the diagnostic cases in the initial assessment were similar for participants in the basic science (0.65 ± 0.11) and clinical learning (0.62 ± 0.11) conditions. The difference was not significant (t[42] = 0.90, p = 0.37, d = 0.27). Analysis of the diagnostic cases on the PFLA revealed significantly higher mean ± SD scores for participants in the basic science learning condition (0.72 ± 0.14) compared with those in the clinical learning condition (0.63 ± 0.15) (t[42] = 2.02, p = 0.05, d = 0.62). Our results show that the inclusion of basic science instruction enhanced the learning of novel related content. We discuss this finding within the broader context of research on basic science instruction, development of adaptive expertise and assessment in medical education. © 2014 John Wiley & Sons Ltd.

Basic Energy Sciences Exascale Requirements Review. An Office of Science review sponsored jointly by Advanced Scientific Computing Research and Basic Energy Sciences, November 3-5, 2015, Rockville, Maryland

DOE Office of Scientific and Technical Information (OSTI.GOV)

Windus, Theresa; Banda, Michael; Devereaux, Thomas

Computers have revolutionized every aspect of our lives. Yet in science, the most tantalizing applications of computing lie just beyond our reach. The current quest to build an exascale computer with one thousand times the capability of today’s fastest machines (and more than a million times that of a laptop) will take researchers over the next horizon. The field of materials, chemical reactions, and compounds is inherently complex. Imagine millions of new materials with new functionalities waiting to be discovered — while researchers also seek to extend those materials that are known to a dizzying number of new forms. Wemore » could translate massive amounts of data from high precision experiments into new understanding through data mining and analysis. We could have at our disposal the ability to predict the properties of these materials, to follow their transformations during reactions on an atom-by-atom basis, and to discover completely new chemical pathways or physical states of matter. Extending these predictions from the nanoscale to the mesoscale, from the ultrafast world of reactions to long-time simulations to predict the lifetime performance of materials, and to the discovery of new materials and processes will have a profound impact on energy technology. In addition, discovery of new materials is vital to move computing beyond Moore’s law. To realize this vision, more than hardware is needed. New algorithms to take advantage of the increase in computing power, new programming paradigms, and new ways of mining massive data sets are needed as well. This report summarizes the opportunities and the requisite computing ecosystem needed to realize the potential before us. In addition to pursuing new and more complete physical models and theoretical frameworks, this review found that the following broadly grouped areas relevant to the U.S. Department of Energy (DOE) Office of Advanced Scientific Computing Research (ASCR) would directly affect the Basic Energy Sciences (BES) mission need. Simulation, visualization, and data analysis are crucial for advances in energy science and technology. Revolutionary mathematical, software, and algorithm developments are required in all areas of BES science to take advantage of exascale computing architectures and to meet data analysis, management, and workflow needs. In partnership with ASCR, BES has an emerging and pressing need to develop new and disruptive capabilities in data science. More capable and larger high-performance computing (HPC) and data ecosystems are required to support priority research in BES. Continued success in BES research requires developing the next-generation workforce through education and training and by providing sustained career opportunities.« less

1.4 Research and the dental student.

PubMed

DePaola, Dominick; Howell, Howard; Baker, Charles G; Boy-Lefevre, Marie Laure; Hull, Peter; Holmstrup, Palle; Jerolimov, Vjekoslav; Hardwick, Kevin; Lamster, Ira B; Lopez, Nestor J; Rifkin, Barry

2002-01-01

There has been significant concern that the dental curriculum and system of clinical education, in particular, is not designed to take advantage of the explosion in knowledge in biomedical science and its application to the health of the public. Although there are some examples of innovations in dental education on a global scale that have the capacity to increase the assimilation of basic and clinical knowledge, most of the dental education models are mired in the traditional '2 + 2' approach to education. This can be seen in North America and the European '2 + 3' model or the stomatological '4 + 2' approach. In each of these systems, the basic and behavioural science courses continue to be perceived as hurdles over which students must leap in order to reach the clinical programmes where there is little opportunity to use basic science information to advance patient care and treatment. Examples of issues that are not well represented include: innovations in imaging; diagnosis; bio-materials; science-based approaches to clinical practice; novel approaches to therapeutics; interactions between the oral, dental and craniofacial complex and systemic health and disorders; the role of oral infections and systemic disease; the increasing appreciation of chronic diseases and disorders such as osteoporosis and diabetes that affect oral tissues; the promise of bioengineering, tissue engineering and biomimetics; the potential use of saliva as a diagnostic tool; the understanding of oral complications of cancer treatment; the treatments of HIV/AIDS diseases and hepatitis; the use of dental and dental hygiene staff on health-care teams to deal with issues such as birth defects, orofacial trauma, head and neck cancer, chronic pain management and so on. There seems to be an excessive emphasis on restorative dentistry and, to a lesser extent, on the more biological approaches to diagnosis, prevention and therapeutics. This continued lack of integration of basic and clinical sciences in the curriculum continues to foster a dental workforce that is highly technically competent to provide specific clinical services but poorly equipped to evaluate and implement new biological approaches to diagnosis, therapeutics and intervention. Unfortunately, after many attempts by organized dental symposia aimed at the integration of basic and clinical sciences, there has been little discernible curricular change. It appears that there is an opportunity through this global congress to identify the best practices in the various global curricula that could change this paradigm in dental education and lead us toward the education of a more scientifically orientated practitioner-one who can take advantage of innovations in new and emerging technologies in their application to patient care. It is the challenge of this section to try to ascertain the best method or methods by which dental education promotes research to the dental student and what research represents in terms of critical thinking and evidence-based approaches to dental education and clinical practice.

Neuromas

MedlinePlus

... and Reimbursement Basics APMA Career Center Your APMA Leadership Opportunities Early Career Resources Academic and Scientific Resources Practice Management & Reimbursement Coding Resources Coding Resource Center Reimbursement Resources ...

Microgravity Combustion Science: 1995 Program Update

NASA Technical Reports Server (NTRS)

Ross, Howard D. (Editor); Gokoglu, Suleyman A. (Editor); Friedman, Robert (Editor)

1995-01-01

Microgravity greatly benefits the study of fundamental combustion processes. In this environment, buoyancy-induced flow is nearly eliminated, weak or normally obscured forces and flows can be isolated, gravitational settling or sedimentation is nearly eliminated, and temporal and spatial scales can be expanded. This document reviews the state of knowledge in microgravity combustion science with the emphasis on NASA-sponsored developments in the current period of 1992 to early 1995. The subjects cover basic research in gaseous premixed and diffusion-flame systems, flame structure and sooting, liquid droplets and pools, and solid-surface ignition and flame spread. They also cover applied research in combustion synthesis of ceramic-metal composites, advanced diagnostic instrumentation, and on-orbit fire safety. The review promotes continuing research by describing the opportunities for Principal Investigator participation through the NASA Research Announcement program and the available NASA Lewis Research Center ground-based facilities and spaceflight accommodations. This review is compiled by the members and associates of the NASA Lewis Microgravity Combustion Branch, and it serves as an update of two previous overview reports.

Developing Geosciences Research Partnerships With Colleagues from SOPAC

NASA Astrophysics Data System (ADS)

Edsall, D. W.

2003-12-01

Members of the AGU have an opportunity to become involved in cooperative research with scientists from the Cook Islands, Fiji, Guam, Federated States of Micronesia, Kiribati, Marshall Islands, Papua New Guinea, Solomon Islands, Tonga, Tuvalu, Vanuatu, Western Samoa as well as Australia and New Zealand. Governmental officials and scientists from the member countries of the South Pacific Applied Geoscience Commission (SOPAC) and its Science Technology and Resources Network (STAR) are looking for individuals, academic and research organizations, foundations, private industry, governmental agencies and professional societies to assist with important research efforts. Involvement would include: promoting; training; funding; equipping, facilitating; coordinating; advising; monitoring; collaborating; interpreting; evaluating and reporting. Studies in all onshore, coastal and offshore environments are needed. Topics include: development of natural resources; reduction of environmental vulnerability; support of sustainable development; development of potable water supplies; protecting coral reef environments; and basic investigations of local weather, climatology, biology, geology, geophysics and oceanography. This paper addresses ways to create such research partnerships.

Space Rocks Tell Their Secrets: Space Science Applications of Physics and Chemistry for High School and College Classes

NASA Technical Reports Server (NTRS)

Lindstrom, M. M.; Tobola, K. W.; Stocco, K.; Henry, M.; Allen, J. S.

2003-01-01

As the scientific community studies Mars remotely for signs of life and uses Martian meteorites as its only available samples, teachers, students, and the general public continue to ask, "How do we know these meteorites are from Mars?" This question sets the stage for a three-lesson instructional package Space Rocks Tell Their Secrets. Expanding on the short answer "It's the chemistry of the rock", students are introduced to the research that reveals the true identities of the rocks. Since few high school or beginning college students have the opportunity to participate in this level of research, a slide presentation introduces them to the labs, samples, and people involved with the research. As they work through the lessons and interpret real data, students realize that the research is an application of basic science concepts they should know, the electromagnetic spectrum and isotopes. They can understand the results without knowing how to do the research or operate the instruments.

Harnessing neuroplasticity for clinical applications

PubMed Central

Sur, Mriganka; Dobkin, Bruce H.; O'Brien, Charles; Sanger, Terence D.; Trojanowski, John Q.; Rumsey, Judith M.; Hicks, Ramona; Cameron, Judy; Chen, Daofen; Chen, Wen G.; Cohen, Leonardo G.; deCharms, Christopher; Duffy, Charles J.; Eden, Guinevere F.; Fetz, Eberhard E.; Filart, Rosemarie; Freund, Michelle; Grant, Steven J.; Haber, Suzanne; Kalivas, Peter W.; Kolb, Bryan; Kramer, Arthur F.; Lynch, Minda; Mayberg, Helen S.; McQuillen, Patrick S.; Nitkin, Ralph; Pascual-Leone, Alvaro; Reuter-Lorenz, Patricia; Schiff, Nicholas; Sharma, Anu; Shekim, Lana; Stryker, Michael; Sullivan, Edith V.; Vinogradov, Sophia

2011-01-01

Neuroplasticity can be defined as the ability of the nervous system to respond to intrinsic or extrinsic stimuli by reorganizing its structure, function and connections. Major advances in the understanding of neuroplasticity have to date yielded few established interventions. To advance the translation of neuroplasticity research towards clinical applications, the National Institutes of Health Blueprint for Neuroscience Research sponsored a workshop in 2009. Basic and clinical researchers in disciplines from central nervous system injury/stroke, mental/addictive disorders, paediatric/developmental disorders and neurodegeneration/ageing identified cardinal examples of neuroplasticity, underlying mechanisms, therapeutic implications and common denominators. Promising therapies that may enhance training-induced cognitive and motor learning, such as brain stimulation and neuropharmacological interventions, were identified, along with questions of how best to use this body of information to reduce human disability. Improved understanding of adaptive mechanisms at every level, from molecules to synapses, to networks, to behaviour, can be gained from iterative collaborations between basic and clinical researchers. Lessons can be gleaned from studying fields related to plasticity, such as development, critical periods, learning and response to disease. Improved means of assessing neuroplasticity in humans, including biomarkers for predicting and monitoring treatment response, are needed. Neuroplasticity occurs with many variations, in many forms, and in many contexts. However, common themes in plasticity that emerge across diverse central nervous system conditions include experience dependence, time sensitivity and the importance of motivation and attention. Integration of information across disciplines should enhance opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies. PMID:21482550

Musculoskeletal discipline science plan

NASA Technical Reports Server (NTRS)

1991-01-01

Life sciences research in the musculoskeletal discipline must identify possible consequences of weightlessness on this system, understand the mechanisms of these effects, and develop effective and operationally practical countermeasures to protect crewmembers. The musculoskeletal system is highly plastic in that is possesses the inherent capability to adapt its structural and functional properties in accordance with the type and degree of stimuli imposed on it. Prolonged space travel is essentially a period of significant unloading of the musculoskeletal system. This results in adaptive responses in the structure and function of this system, placing it on the low end of a continuum from one of complete disuse to one of maximal use. There is a high probability that the musculoskeletal system is functionally impaired with increasing duration of weightlessness. The purpose of this Discipline Science Plan is to provide a conceptual strategy for NASA's Life Sciences division research and development activities in the area of musculoskeletal function. This document summarizes the current status of the program, outlines available knowledge, establishes goals and objectives, identifies science priorities, and defines research opportunities, which encompass critical questions in the subdiscipline areas (e.g., muscle, bone, and other musculoskeletal connective tissues). These science activities include ground-based and flight; basic, applied, and operational; and animal and human research and development. This document contains a general plan that will be used by both NASA Headquarters Program Offices and the field centers to review and plan basic, applied, and operational intramural and extramural research and development activities in this area.

Genome Engineering with TALE and CRISPR Systems in Neuroscience

PubMed Central

Lee, Han B.; Sundberg, Brynn N.; Sigafoos, Ashley N.; Clark, Karl J.

2016-01-01

Recent advancement in genome engineering technology is changing the landscape of biological research and providing neuroscientists with an opportunity to develop new methodologies to ask critical research questions. This advancement is highlighted by the increased use of programmable DNA-binding agents (PDBAs) such as transcription activator-like effector (TALE) and RNA-guided clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated (Cas) systems. These PDBAs fused or co-expressed with various effector domains allow precise modification of genomic sequences and gene expression levels. These technologies mirror and extend beyond classic gene targeting methods contributing to the development of novel tools for basic and clinical neuroscience. In this Review, we discuss the recent development in genome engineering and potential applications of this technology in the field of neuroscience. PMID:27092173

Genome Engineering with TALE and CRISPR Systems in Neuroscience.

PubMed

Lee, Han B; Sundberg, Brynn N; Sigafoos, Ashley N; Clark, Karl J

2016-01-01

Recent advancement in genome engineering technology is changing the landscape of biological research and providing neuroscientists with an opportunity to develop new methodologies to ask critical research questions. This advancement is highlighted by the increased use of programmable DNA-binding agents (PDBAs) such as transcription activator-like effector (TALE) and RNA-guided clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated (Cas) systems. These PDBAs fused or co-expressed with various effector domains allow precise modification of genomic sequences and gene expression levels. These technologies mirror and extend beyond classic gene targeting methods contributing to the development of novel tools for basic and clinical neuroscience. In this Review, we discuss the recent development in genome engineering and potential applications of this technology in the field of neuroscience.

Status and opportunities for genomics research with rainbow trout

USGS Publications Warehouse

Thorgaard, G.H.; Bailey, G.S.; Williams, D.; Buhler, D.R.; Kaattari, S.L.; Ristow, S.S.; Hansen, J.D.; Winton, J.R.; Bartholomew, J.L.; Nagler, J.J.; Walsh, P.J.; Vijayan, M.M.; Devlin, R.H.; Hardy, R.W.; Overturf, K.E.; Young, W.P.; Robison, B.D.; Rexroad, C.; Palti, Y.

2002-01-01

The rainbow trout (Oncorhynchus mykiss) is one of the most widely studied of model fish species. Extensive basic biological information has been collected for this species, which because of their large size relative to other model fish species are particularly suitable for studies requiring ample quantities of specific cells and tissue types. Rainbow trout have been widely utilized for research in carcinogenesis, toxicology, comparative immunology, disease ecology, physiology and nutrition. They are distinctive in having evolved from a relatively recent tetraploid event, resulting in a high incidence of duplicated genes. Natural populations are available and have been well characterized for chromosomal, protein, molecular and quantitative genetic variation. Their ease of culture, and experimental and aquacultural significance has led to the development of clonal lines and the widespread application of transgenic technology to this species. Numerous microsatellites have been isolated and two relatively detailed genetic maps have been developed. Extensive sequencing of expressed sequence tags has begun and four BAC libraries have been developed. The development and analysis of additional genomic sequence data will provide distinctive opportunities to address problems in areas such as evolution of the immune system and duplicate genes. ?? 2002 Elsevier Science Inc. All rights reserved.

Self-definition of women experiencing a nontraditional graduate fellowship program

NASA Astrophysics Data System (ADS)

Buck, Gayle A.; Leslie-Pelecky, Diandra L.; Lu, Yun; Plano Clark, Vicki L.; Creswell, John W.

2006-10-01

Women continue to be underrepresented in the fields of science, technology, engineering, and mathematics (STEM). One factor contributing to this underrepresentation is the graduate school experience. Graduate programs in STEM fields are constructed around assumptions that ignore the reality of women's lives; however, emerging opportunities may lead to experiences that are more compatible for women. One such opportunity is the Graduate Teaching Fellows in K-12 Education (GK-12) Program, which was introduced by the National Science Foundation in 1999. Although this nontraditional graduate program was not designed explicitly for women, it provided an unprecedented context in which to research how changing some of the basic assumptions upon which a graduate school operates may impact women in science. This exploratory case study examines the self-definition of 8 women graduate students who participated in a GK-12 program at a major research university. The findings from this case study contribute to higher education's understanding of the terrain women graduate students in the STEM areas must navigate as they participate in programs that are thought to be more conducive to their modes of self-definition while they continue to seek to be successful in the historically Eurocentric, masculine STEM fields.

Certifying Functional Literacy: Competency Testing and Implications for Due Process and Equal Educational Opportunity.

ERIC Educational Resources Information Center

Lewis, Donald Marion

1979-01-01

Demonstrates the role the guarantee of due process can play in ensuring that vital interests in public education not be lost through erroneous assessments of a student's proficiency in basic skills, and describes the limits constitutional and statutory guarantees of equal educational opportunity place on the use of competency testing. (Author/IRT)

OIO [Oklahomans for Indian Opportunity, Inc.] Indian Youth Council Manual.

ERIC Educational Resources Information Center

Oklahomans for Indian Opportunity, Inc., Norman, OK.

The Oklahomans for Indian Opportunity (OIO) Youth Council Manual is divided into 5 parts. The first gives some basic information about the OIO Youth Councils, covering what a Youth Council is, who can join, the organization of the Councils, who runs them and how they work, the sponsor's role, recognition by local schools, initiating new Councils,…

Physical Education Opportunity Program for Exceptional Learners (PEOPEL): A Teacher's Guide for Secondary Schools. Second Edition.

ERIC Educational Resources Information Center

Irmer, Larry D.; And Others

The instructional guide for PEOPEL (Physical Education Opportunity Program for Exceptional Learners) contains 36 units of instruction for use with handicapped junior and senior high school students. The units contain basic performance objectives which have been task analyzed in an effort to individualize instruction. Each unit is divided into four…

Alternate Jobs for Aerospace Workers. Examples of Employment Opportunities in Private Industry.

ERIC Educational Resources Information Center

Draper, A. M. Leslie

Based on a survey of the characteristics of unemployed aerospace workers, this is the second of two reports developed to suggest alternate job opportunities in private industry for unemployed aerospace engineers and scientists. Included in the brief summaries of 70 jobs found in private industry are general, basic requirements and kinds of…

Project GOLD: Growth Opportunities through Learning & Doing, Performance Reporting Period, November 1, 1996-February 28, 1998. National Workplace Literacy Program.

ERIC Educational Resources Information Center

Seminole Community Coll., Sanford, FL.

Project "Growth Opportunities through Learning and Doing" (GOLD), Seminole Community College's basic skills update program, enrolled 107 students at 2 manufacturing facilities from April 1995-February 1998. Employees from Siemens Telecom Network (formerly known as Siemens Stromberg-Carlson) studied offsite in a classroom equipped with 10 computers…

Accelerating Opportunity: A Portrait of Students and Their Program Experiences from the 2014 Student Survey

ERIC Educational Resources Information Center

Spaulding, Shayne; Martin-Caughey, Ananda

2015-01-01

This report presents findings from a survey of students enrolled in Accelerating Opportunity (AO) career pathways in spring 2014. AO provides grants to help community colleges create career pathway programs to enroll students with low basic skills into for-credit career and technical education courses to improve educational and employment…

Inconsistencies in Awarding Financial Aid to Students Under Four Federal Programs. Report to the Congress of the United States by the Comptroller General.

ERIC Educational Resources Information Center

Comptroller General of the U.S., Washington, DC.

Four federal programs were investigated for inconsistencies in awarding financial aid to college students: the Supplemental Educational Opportunity Grants, Basic Educational Opportunity Grants, College Work-Study Program, and National Direct Student Loan Program. Their methods for determining student need and their legislative histories are…

Linking neuroimaging signals to behavioral responses in single cases: Challenges and opportunities.

PubMed

Sander, Tilmann H; Zhou, Bin

2016-09-01

Despite rapid progress both in psychology and neuroimaging, there is still a convergence gap between the results of these two scientific disciplines. This is particularly unsatisfactory, as the variability between single subjects needs to be understood both for basic science and for patient diagnostics in, for example, the field of age-related cognitive changes. Active and passive behaviors are the observables in psychology and can be studied alone or in combination with the neuroimaging approach. Various physical signatures of brain activity are the observables in neuroimaging and can be measured concurrent with behaviors. Despite the intrinsic relationship between behaviors and the corresponding neuroimaging patterns and the obvious advantages in integrating behavioral and neuroimaging measurements, the results of combined studies can be difficult to interpret. Experiments are often optimized to yield either a novel behavioral or a novel physiological result, but rarely designed for a better match between the two. Since integrating the results is probably a key to future progress in clinical psychology and basic research, an attempt is made here to identify some difficulties and to provide some ideas for future research. © 2016 The Institute of Psychology, Chinese Academy of Sciences and John Wiley & Sons Australia, Ltd.

Barrier Busting: Leapfrogging Zombie Science Arguments to Get to Solutions

NASA Astrophysics Data System (ADS)

Hassol, S. J.

2015-12-01

Climate literacy certainly requires a basic understanding of the causes and impacts of climate change, and this has motivated our community to focus on ever better ways to communicate this knowledge. This has been very worthwhile. But continuing to dwell on refuting climate myths that seem impossible to put to rest has often kept us mired in the framing of those who reject the science and seek to stall action. Moving past misconceptions and barriers may require added emphasis on responses to climate change. Research focused on the American public has revealed a broader acceptance of the reality of climate change than many people think. In particular, there is broad support for solutions, such as clean energy, even among those who say they do not accept that human activity is the primary driver of climate change. This presents an opportunity to open a side door to understanding that avoids unproductive confrontation with ideological barriers. Research is also revealing effective models for behavioral change that tap into social norms. Leapfrogging basic science arguments and going straight to solutions that most agree on can help us clear some of the barriers to understanding and the hurdles to action.

Implications of learning theory for developing programs to decrease overeating

PubMed Central

Boutelle, Kerri N.; Bouton, Mark E.

2015-01-01

Childhood obesity is associated with medical and psychological comorbidities, and interventions targeting overeating could be pragmatic and have a significant impact on weight. Calorically dense foods are easily available, variable, and tasty which allows for effective opportunities to learn to associate behaviors and cues in the environment with food through fundamental conditioning processes, resulting in measurable psychological and physiological food cue reactivity in vulnerable children. Basic research suggests that initial learning is difficult to erase, and that it is vulnerable to a number of phenomena that will allow the original learning to re-emerge after it is suppressed or replaced. These processes may help explain why it may be difficult to change food cue reactivity and overeating over the long term. Extinction theory may be used to develop effective cue-exposure treatments to decrease food cue reactivity through inhibitory learning, although these processes are complex and require an integral understanding of the theory and individual differences. Additionally, learning theory can be used to develop other interventions that may prove to be useful. Through an integration of learning theory, basic and translational research, it may be possible to develop interventions that can decrease the urges to overeat, and improve the weight status of children. PMID:25998235

Clusters and Factors Associated with Complementary Basic Education in Tanzania Mainland

ERIC Educational Resources Information Center

Edwin, Paul; Amina, Msengwa S.; Godwin, Naimani M.

2017-01-01

Complimentary Basic Education in Tanzania (COBET) is a community-based programme initiated in 1999 to provide formal education system opportunity to over aged children or children above school age. The COBET program was analyzed using secondary data collected from 21 regions from 2008 to 2012. Cluster analysis was applied to classify the 21…

Strategies and Policies for Basic Education in Cambodia: Historical Perspectives

ERIC Educational Resources Information Center

Dy, Sideth S.

2004-01-01

This article examines the process of development and change in the state of education in Cambodia over four decades preceding the 1990 Jomtien World Conference on Education for All. The author argues that during the 1950s and 1960s, efforts to enhance basic education opportunities for all Cambodians were largely unsuccessful due to the lack of…

Statistical Match of the VA 1979-1980 Recipient File against the 1979-1980 Basic Grant Recipient File. Revised.

ERIC Educational Resources Information Center

Applied Management Sciences, Inc., Silver Spring, MD.

The amount of misreporting of Veterans Administration (VA) benefits was assessed, along with the impact of misreporting on the Basic Educational Opportunity Grant (BEOG) program. Accurate financial information is need to determine appropriate awards. The analysis revealed: over 97% of VA beneficiaries misreported benefits; the total net loss to…

Quality in the Basic Grant Delivery System: Volume 2, Corrective Actions.

ERIC Educational Resources Information Center

Advanced Technology, Inc., McLean, VA.

Alternative management procedures are recommended that may lower the rate and magnitude of errors in the award of the Basic Educational Opportunity Grants (BEOGs), or Pell Grants. The recommendations are part of the BEOG quality control project and are based on a review of current (1980-1981) levels, distribution, and significance of error in the…

Quality in the Basic Grant Delivery System: Executive Summary.

ERIC Educational Resources Information Center

Advanced Technology, Inc., McLean, VA.

Findings of a study of 1980-1981 award accuracy of the Basic Educational Opportunity Grants (BEOGs), or Pell Grants, are summarized. The study is the first stage of a three-stage quality control project and includes recommended corrective actions to reduce inaccuracies in the grant awards. A sample of 4,500 students were selected as representative…

Validation of Student and Parent Reported Data on the Basic Grant Application Form. Project Summary.

ERIC Educational Resources Information Center

Applied Management Sciences, Inc., Silver Spring, MD.

Results of studies to assess accuracy of information reported by applicants to the Basic Educational Opportunity Grant (BEOG) program are summarized. Attention is also focused on applicant characteristics and corrective actions taken as a result of the studies. Overall, the studies found that the majority of BEOG applicants reported income…

Validation, Edits, and Application Processing System Report: Phase I.

ERIC Educational Resources Information Center

Gray, Susan; And Others

Findings of phase 1 of a study of the 1979-1980 Basic Educational Opportunity Grants validation, edits, and application processing system are presented. The study was designed to: assess the impact of the validation effort and processing system edits on the correct award of Basic Grants; and assess the characteristics of students most likely to…

Foot Surgery

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Athlete's Foot

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Heel Pain

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Collection and analysis of remotely sensed data from the Rhode River Estuary Watershed. [ecological parameters of Chesapeake Bay

NASA Technical Reports Server (NTRS)

Jenkins, D. W.

1972-01-01

NASA chose the watershed of Rhode River, a small sub-estuary of the Bay, as a representative test area for intensive studies of remote sensing, the results of which could be extrapolated to other estuarine watersheds around the Bay. A broad program of ecological research was already underway within the watershed, conducted by the Smithsonian Institution's Chesapeake Bay Center for Environmental Studies (CBCES) and cooperating universities. This research program offered a unique opportunity to explore potential applications for remote sensing techniques. This led to a joint NASA-CBCES project with two basic objectives: to evaluate remote sensing data for the interpretation of ecological parameters, and to provide essential data for ongoing research at the CBCES. A third objective, dependent upon realization of the first two, was to extrapolate photointerpretive expertise gained at the Rhode River watershed to other portions of the Chesapeake Bay.

Children's Interstitial and Diffuse Lung Disease. Progress and Future Horizons.

PubMed

Deterding, Robin R

2015-10-01

Children's interstitial and diffuse lung disease (chILD) is a term that encompasses a large and diverse group of rare pediatric diseases and disorders. Significant progress has been made over the last 2 decades in classification, clinical care, research, and organizational structure to enhance the care of children with these high-morbidity and -mortality diseases. New diseases have been defined clinically and genetically, classification systems developed and applied, organizations formed such as the chILD Research Network (chILDRN) and chILD Foundation, and basic and translational science expanded to focus on chILD diseases. Multidisciplinary collaborations and efforts to advance understanding and treatment of chILD have been extended worldwide. The future horizon holds great promise to expand scientific discoveries, collaborate more broadly, and bring new treatment to these children. An overview of key historical past developments, major clinical and research updates, and opportunities for the future in chILD is reviewed in this Perspective.

An ion accelerator for undergraduate research and teaching

NASA Astrophysics Data System (ADS)

Monce, Michael

1997-04-01

We have recently upgraded our 400kV, single beam line ion accelerator to a 1MV, multiple beam line machine. This upgrade has greatly expanded the opportunities for student involvement in the laboratory. We will describe four areas of work in which students now participate. The first is the continuing research being conducted in excitations produced in ion-molecule collisions, which recently involved the use of digital imaging. The second area of research now opened up by the new accelerator involves PIXE. We are currently beginning a cross disciplinary study of archaeological specimens using PIXE and involving students from both anthropology and physics. Finally, two beam lines from the accelerator will be used for basic work in nuclear physics: Rutherford scattering and nuclear resonances. These two nuclear physics experiments will be integrated into our sophomore-junior level, year-long course in experimental physics.

PV opportunities in India

NASA Astrophysics Data System (ADS)

Stone, Jack L.; Ullal, Harin S.

1996-01-01

The growing middle class in India, coupled with a need for electricity to provide basic services to the masses, provides an opportunity to deploy photovoltaic systems in cost-effective applications ranging from grid-connected to isolated location requirements. This need is being satisfied by aggressive government programs, the availability of funds from agencies such as the World Bank, and the desire of Indian industries to form joint ventures for in-country manufacturing. The relaxed restrictions on doing business in India makes today's opportunities timely indeed.

Human behavioral research in space: quandaries for research subjects and researchers

NASA Technical Reports Server (NTRS)

Shepanek, Marc

2005-01-01

With the advent of long-duration spaceflight on board the International Space Station (ISS) and possible future missions beyond low Earth orbit (LEO) such as Mars, it is critical that those at NASA have a realistic assessment of the challenges that will face individuals on long-duration missions so that they can develop preventive and real-time countermeasures to behavioral health issues. While space travellers are very interested in having countermeasures to the deleterious effects of space missions, they have a powerful disincentive to participate in this research if they feel it could in any way negatively affect their flight status. The behavioral issues of isolation and confinement for extended-duration space missions are reviewed. Areas of basic and clinical behavioral research are listed. And the classical clinical model for research is not considered appropriate for the current configuration of the space program. The use of analogue environments and advanced statistical analysis are suggested as ways to address the limited spaceflight research opportunities. The challenge of research subject or patient confidentiality vs. mission safety and issues of personal flight status are addressed.

U.S. Environmental Protection Agency national network of research centers: A case study in socio-political influences on research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morehouse, K.

1995-12-01

During the 15 years that the U.S. Environmental Protection Agency (EPA) has supported university-based research centers, there have been many changes in mission, operating style, funding level, eligibility, and selection process. Even the definition of the term {open_quotes}research center{close_quotes} is open to debate. Shifting national priorities, political realities, and funding uncertainties have powered the evolution of research centers in EPA, although the agency`s basic philosophy on the purpose and value of this approach to research remains essentially unchanged. Today, EPA manages 28 centers, through the Office of Exploratory Research. These centers are administered under three distinct programs. Each program hasmore » its own mission and goals which guide the way individual centers are selected and operated. This paper will describe: (1) EPA`s philosophy of reserach centers, (2) the complicated history of EPA research centers, (3) coordination and interaction among EPA centers and others, (4) opportunities for collaboration, and (5) plans for the future.« less

Human behavioral research in space: quandaries for research subjects and researchers.

PubMed

Shepanek, Marc

2005-06-01

With the advent of long-duration spaceflight on board the International Space Station (ISS) and possible future missions beyond low Earth orbit (LEO) such as Mars, it is critical that those at NASA have a realistic assessment of the challenges that will face individuals on long-duration missions so that they can develop preventive and real-time countermeasures to behavioral health issues. While space travellers are very interested in having countermeasures to the deleterious effects of space missions, they have a powerful disincentive to participate in this research if they feel it could in any way negatively affect their flight status. The behavioral issues of isolation and confinement for extended-duration space missions are reviewed. Areas of basic and clinical behavioral research are listed. And the classical clinical model for research is not considered appropriate for the current configuration of the space program. The use of analogue environments and advanced statistical analysis are suggested as ways to address the limited spaceflight research opportunities. The challenge of research subject or patient confidentiality vs. mission safety and issues of personal flight status are addressed.

Improving Motor and Drive System Performance – A Sourcebook for Industry

DOE Office of Scientific and Technical Information (OSTI.GOV)

None

This sourcebook outlines opportunities to improve motor and drive systems performance. The sourcebook is divided into four main sections: (1) Motor and Drive System Basics: Summarizes important terms, relationships, and system design considerations relating to motor and drive systems. (2) Performance Opportunity Road Map: Details the key components of well-functioning motor and drive systems and opportunities for energy performance opportunities. (3) Motor System Economics: Offers recommendations on how to propose improvement projects based on corporate priorities, efficiency gains, and financial payback periods. (4) Where to Find Help: Provides a directory of organizations associated with motors and drives, as well asmore » resources for additional information, tools, software, videos, and training opportunities.« less

Rutgers Young Horse Teaching and Research Program: undergraduate student outcomes.

PubMed

Ralston, Sarah L

2012-12-01

Equine teaching and research programs are popular but expensive components of most land grant universities. External funding for equine research, however, is limited and restricts undergraduate research opportunities that enhance student learning. In 1999, a novel undergraduate teaching and research program was initiated at Rutgers University, New Brunswick, NJ. A unique aspect of this program was the use of young horses generally considered "at risk" and in need of rescue but of relatively low value. The media interest in such horses was utilized to advantage to obtain funding for the program. The use of horses from pregnant mare urine (PMU) ranches and Bureau of Land Management (BLM) mustangs held the risks of attracting negative publicity, potential of injury while training previously unhandled young horses, and uncertainty regarding re-sale value; however, none of these concerns were realized. For 12 years the Young Horse Teaching and Research Program received extensive positive press and provided invaluable learning opportunities for students. Over 500 students, at least 80 of which were minorities, participated in not only horse management and training but also research, event planning, public outreach, fund-raising, and website development. Public and industry support provided program sustainability with only basic University infrastructural support despite severe economic downturns. Student research projects generated 25 research abstracts presented at national and international meetings and 14 honors theses. Over 100 students went on to veterinary school or other higher education programs, and more than 100 others pursued equine- or science-related careers. Laudatory popular press articles were published in a wide variety of breed/discipline journals and in local and regional newspapers each year. Taking the risk of using "at risk" horses yielded positive outcomes for all, especially the undergraduate students.

Sweaty Feet (Hyperhidrosis)

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Corns and Calluses

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Diabetic Wound Care

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Toenail Fungus (Onychomycosis)

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Chromatin regulation at the frontier of synthetic biology.

PubMed

Keung, Albert J; Joung, J Keith; Khalil, Ahmad S; Collins, James J

2015-03-01

As synthetic biology approaches are extended to diverse applications throughout medicine, biotechnology and basic biological research, there is an increasing need to engineer yeast, plant and mammalian cells. Eukaryotic genomes are regulated by the diverse biochemical and biophysical states of chromatin, which brings distinct challenges, as well as opportunities, over applications in bacteria. Recent synthetic approaches, including 'epigenome editing', have allowed the direct and functional dissection of many aspects of physiological chromatin regulation. These studies lay the foundation for biomedical and biotechnological engineering applications that could take advantage of the unique combinatorial and spatiotemporal layers of chromatin regulation to create synthetic systems of unprecedented sophistication.

Electric load management and energy conservation

NASA Technical Reports Server (NTRS)

Kheir, N. A.

1976-01-01

Electric load management and energy conservation relate heavily to the major problems facing power industry at present. The three basic modes of energy conservation are identified as demand reduction, increased efficiency and substitution for scarce fuels. Direct and indirect load management objectives are to reduce peak loads and have future growth in electricity requirements in such a manner to cause more of it to fall off the system's peak. In this paper, an overview of proposed and implemented load management options is presented. Research opportunities exist for the evaluation of socio-economic impacts of energy conservation and load management schemes specially on the electric power industry itself.

Scientific bases of human-machine communication by voice.

PubMed Central

Schafer, R W

1995-01-01

The scientific bases for human-machine communication by voice are in the fields of psychology, linguistics, acoustics, signal processing, computer science, and integrated circuit technology. The purpose of this paper is to highlight the basic scientific and technological issues in human-machine communication by voice and to point out areas of future research opportunity. The discussion is organized around the following major issues in implementing human-machine voice communication systems: (i) hardware/software implementation of the system, (ii) speech synthesis for voice output, (iii) speech recognition and understanding for voice input, and (iv) usability factors related to how humans interact with machines. PMID:7479802

Chromatin regulation at the frontier of synthetic biology

PubMed Central

Keung, Albert J.; Joung, J. Keith; Khalil, Ahmad S.; Collins, James J.

2016-01-01

As synthetic biology approaches are extended to diverse applications throughout medicine, biotechnology and basic biological research, there is an increasing need to engineer yeast, plant and mammalian cells. Eukaryotic genomes are regulated by the diverse biochemical and biophysical states of chromatin, which brings distinct challenges, as well as opportunities, over applications in bacteria. Recent synthetic approaches, including `epigenome editing', have allowed the direct and functional dissection of many aspects of physiological chromatin regulation. These studies lay the foundation for biomedical and biotechnological engineering applications that could take advantage of the unique combinatorial and spatiotemporal layers of chromatin regulation to create synthetic systems of unprecedented sophistication. PMID:25668787

Crowdsourcing biomedical research: leveraging communities as innovation engines

PubMed Central

Saez-Rodriguez, Julio; Costello, James C.; Friend, Stephen H.; Kellen, Michael R.; Mangravite, Lara; Meyer, Pablo; Norman, Thea; Stolovitzky, Gustavo

2018-01-01

The generation of large-scale biomedical data is creating unprecedented opportunities for basic and translational science. Typically, the data producers perform initial analyses, but it is very likely that the most informative methods may reside with other groups. Crowdsourcing the analysis of complex and massive data has emerged as a framework to find robust methodologies. When the crowdsourcing is done in the form of collaborative scientific competitions, known as Challenges, the validation of the methods is inherently addressed. Challenges also encourage open innovation, create collaborative communities to solve diverse and important biomedical problems, and foster the creation and dissemination of well-curated data repositories. PMID:27418159

Crowdsourcing biomedical research: leveraging communities as innovation engines.

PubMed

Saez-Rodriguez, Julio; Costello, James C; Friend, Stephen H; Kellen, Michael R; Mangravite, Lara; Meyer, Pablo; Norman, Thea; Stolovitzky, Gustavo

2016-07-15

The generation of large-scale biomedical data is creating unprecedented opportunities for basic and translational science. Typically, the data producers perform initial analyses, but it is very likely that the most informative methods may reside with other groups. Crowdsourcing the analysis of complex and massive data has emerged as a framework to find robust methodologies. When the crowdsourcing is done in the form of collaborative scientific competitions, known as Challenges, the validation of the methods is inherently addressed. Challenges also encourage open innovation, create collaborative communities to solve diverse and important biomedical problems, and foster the creation and dissemination of well-curated data repositories.

The neurosurgeon as innovator and entrepreneur.

PubMed

Firlik, A D; Lowry, D W; Levy, A J; Hirsch, R C

2000-07-01

INNOVATION IS THE driving force behind progress in neurosurgery. Most significant innovations require commercialization to ensure appropriate development and ultimate distribution to patients. There are several key factors that determine whether a particular innovation is likely to be commercially successful. Relationships between academic neurosurgeons and industry are likely to increase in the future. Stronger and more productive relationships between academic neurosurgeons and commercial ventures will provide new opportunities for neurosurgeons to bring innovations to patients more effectively and efficiently. The transfer of innovation from the academic environment to the commercial setting is consistent with the academic mission and can increase funding for basic and clinical neuroscience research.

Focusing on Cause or Cure?: Priorities and Stakeholder Presence in Childhood Psychiatry Research.

PubMed

Milner, Lauren C; Cho, Mildred K

2014-01-01

Biomedical research is influenced by many factors, including the involvement of stakeholder groups invested in research outcomes. Stakeholder involvement in research efforts raise questions of justice as their specific interests and motivations play a role in directing research resources that ultimately produce knowledge shaping how different conditions (and affected individuals) are understood and treated by society. This issue is highly relevant to child psychiatry research where diagnostic criteria and treatment strategies are often controversial. Biological similarities and stakeholder differences between attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) provide an opportunity to explore this issue by comparing research foci and stakeholder involvement in these conditions. A subset of ADHD and ASD research articles published between 1970-2010 were randomly selected from the PubMed database and coded for research focus, funding source(s), and author-reported conflicts of interest (COIs). Chi-square analyses were performed to identify differences between and within ADHD and ASD research across time. The proportion of ADHD research dedicated to basic, description, and treatment research was roughly similar and remained stable over time, while ASD research showed a significant increase in basic research over the past decade. Government was the primary research funder for both conditions, but for-profit funders were a notable presence in ADHD research, while joint-funding efforts between non-profit and government funders were a notable presence in ASD research. Lastly, COIs were noted more frequently in ADHD than in ASD research. Our study shows significant differences in research foci and funding sources between the conditions, and identifies the specific involvement of for-profit and non-profit groups in ADHD and ASD, respectively. Our findings highlight the relationship between stakeholders outside the research community and research trajectories and suggest that examinations of these relationships must be included in broader considerations of biomedical research ethics.

Why the American public supports twenty-first century learning.

PubMed

Sacconaghi, Michele

2006-01-01

Aware that constituent support is essential to any educational endeavor, the AOL Time Warner Foundation (now the Time Warner Foundation), in conjunction with two respected national research firms, measured Americans' attitudes toward the implementation of twenty-first century skills. The foundation's national research survey was intended to explore public perceptions of the need for changes in the educational system, in school and after school, with respect to the teaching of twenty-first century skills. The author summarizes the findings of the survey, which were released by the foundation in June 2003. One thousand adults were surveyed by telephone, including African Americans, Latinos, teachers, and business executives. In general, the survey found that Americans believe today's students need a "basics-plus" education, meaning communication, technology, and critical thinking skills in addition to the traditional basics of reading, writing, and math. In fact, 92 percent of respondents stated that students today need different skills from those of ten to twenty years ago. Also, after-school programs were found to be an appropriate vehicle to teach these skills. Furthermore, the survey explored how well the public perceives schools to be preparing youth for the workforce and postsecondary education, which twenty-first century skills are seen as being taught effectively, and the level of need for after-school and summer programs. The survey results provide conclusive evidence of national support for basics-plus education. Thus, a clear opportunity exists to build momentum for a new model of education for the twenty-first century.

Sprains, Strains and Fractures

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Arthritis and the Feet

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The integration of FMEA with other problem solving tools: A review of enhancement opportunities

NASA Astrophysics Data System (ADS)

Ng, W. C.; Teh, S. Y.; Low, H. C.; Teoh, P. C.

2017-09-01

Failure Mode Effect Analysis (FMEA) is one the most effective and accepted problem solving (PS) tools for most of the companies in the world. Since FMEA was first introduced in 1949, practitioners have implemented FMEA in various industries for their quality improvement initiatives. However, studies have shown that there are drawbacks that hinder the effectiveness of FMEA for continuous quality improvement from product design to manufacturing. Therefore, FMEA is integrated with other PS tools such as inventive problem solving methodology (TRIZ), Quality Function Deployment (QFD), Root Cause Analysis (RCA) and seven basic tools of quality to address the drawbacks. This study begins by identifying the drawbacks in FMEA. A comprehensive literature review on the integration of FMEA with other tools is carried out to categorise the integrations based on the drawbacks identified. The three categories are inefficiency of failure analysis, psychological inertia and neglect of customers’ perspective. This study concludes by discussing the gaps and opportunities in the integration for future research.

Training for Leadership Roles in Academic Medicine: Opportunities for Psychologists in the AAMC LEAD Program.

PubMed

LaPaglia, Donna; Thompson, Britta; Hafler, Janet; Chauvin, Sheila

2017-06-01

Psychologists' roles within academic medicine have expanded well beyond research and scholarship. They are active as providers of patient care, medical education, and clinical supervision. Although the number of psychologists in academic health centers continues to grow, they represent a small portion of total medical school faculties. However, with the movement toward collaborative care models, emphasis on interprofessional teams, and increased emphasis on psychological science topics in medical curricula, psychologists are well-positioned to make further contributions. Another path through which psychologists can further increase their contributions and value within academic health centers is to aspire to leadership roles. This article describes the first author's reflections on her experiences in a two-year, cohort-based, educational leadership development certificate program in academic medicine. The cohort was comprised largely of physicians and basic scientists, and a small number of non-physician participants of which the first author was the only clinical psychologist. The insights gained from this experience provide recommendations for psychologists interested in leadership opportunities in academic medicine.

A Survey of Basic Educational Opportunities Available to Members of the Church of Jesus Christ of Latter-Day Saints.

ERIC Educational Resources Information Center

Cameron, J. Elliot

To examine the historical background of educational programs of the Church of Jesus Christ of Latter-Day Saints, the Church population, and educational opportunities available to Church members, a questionnaire was sent to presidents of Church missions outside the United States. It was found that Church membership has increased rapidly and could…

The current state of basic medical education in Israel: implications for a new medical school.

PubMed

Reis, Shmuel; Borkan, Jeffrey M; Weingarten, Michael

2009-11-01

The recent government decision to establish a new medical school, the fifth in Israel, is an opportune moment to reflect on the state of Basic Medical Education (BME) in the country and globally. It provides a rare opportunity for planning an educational agenda tailored to local needs. This article moves from a description of the context of Israeli health care and the medical education system to a short overview of two existing Israeli medical schools where reforms have recently taken place. This is followed by an assessment of Israeli BME and an effort to use the insights from this assessment to inform the fifth medical school blueprint. The fifth medical school presents an opportunity for further curricular reforms and educational innovations. Reforms and innovations include: fostering self-directed professional development methods; emphasis on teaching in the community; use of appropriate educational technology; an emphasis on patient safety and simulation training; promoting the humanities in medicine; and finally the accountability to the community that the graduates will serve.

Lifelong Learning: A New Momentum and a New Opportunity for Adult Basic Learning and Education (ABLE) in the South

ERIC Educational Resources Information Center

Torres, Rosa-Maria

2004-01-01

This article is based on a broad study commissioned by Sida (Swedish International Development Agency) on the status and current trends in adult basic education in Africa, Asia, Latin America, and the Caribbean. The study included a review of relevant documentation in several languages, an electronic survey with key respondents throughout the…

Reports and Testimony: March 1992

DTIC Science & Technology

1992-03-01

pesticide data needs, it is essential that an interaigency strategy guide the progrmn. Otherwise, USDA may be jeopardizing a significant federal...assess the effectiveness of Job Opportunities and Basic Skills Training (JoBs) programs run by Indian Tribes and Alaska Native groups or determine...contractor reporting requirements. irr’s efforts to develop automation systems continue to disappoint. Major systems are plagued by basic problems, including

Validation of Student and Parent Reported Data on the Basic Grant Application Form: Corrections Analysis Study. Final Report, Volume 4.

ERIC Educational Resources Information Center

Vogel, Ronald J.

A study was conducted in 1976 of applicants who submitted corrections or amendments to their Student Eligibility Reports (SERs) for the Basic Educational Opportunity Grant (BEOG) Program. The objective was to review the applications corrections process and to determine factors linked to applicants' use of correction procedures. Attention was…

Financing Education: Opportunities for Global Action

ERIC Educational Resources Information Center

Steer, Liesbet; Smith, Katie

2015-01-01

It is hoped that this year will be marked in history as the year when the world agreed on an ambitious global plan to eradicate poverty and ensure that all children have access to a high-quality basic education. This report focuses on how a subset of the targets related to basic education--that is, that all children should complete high-quality…

TRIENNIAL REPRODUCTION SYMPOSIUM: American Society of Animal Science L. E. Casida Award for Excellence in Graduate Education: Thoughts on mentoring graduate students in reproductive biology.

PubMed

Smith, M F

2016-07-01

Programs in animal science are particularly well suited for graduate education because students can receive comprehensive training in the laboratory as well as with the whole animal. Furthermore, graduate students in animal science have the opportunity to understand how their research relates to a real world problem. Graduate students need to take ownership of their education by identifying training goals, choosing a mentor who will help them achieve their goals, and becoming engaged in research as soon as possible. In my own graduate program, I emphasize concepts more than techniques and I believe that graduate course work should focus on the basic areas of science that underlie reproductive biology (e.g., endocrinology, biochemistry, physiology, immunology, and statistics). Based on the increase in technology available for scientific investigation and the diversity of expertise required to address important research problems, graduate students need to learn the importance of establishing productive collaborations and begin building a scientific network. Preparation for graduate school frequently begins early with a curiosity and passion for understanding how biology works. Undergraduate courses can facilitate scientific thinking by providing opportunities in lectures and laboratories for students to transition from passive learners to thinking of themselves as animal scientists. There is a profound difference between individuals who view themselves as practitioners of a discipline and those who are simply trying to complete a course requirement. Teachers of undergraduate courses should incorporate experiential learning exercises into their lectures and laboratories to provide undergraduate students the opportunity to function as animal scientists and to embrace their scientific education. Graduate training has been the most enjoyable aspect of my career and it has been a joy to witness the achievements of students following completion of their degree!

Turbulence in laboratory and natural plasmas: Connecting the dots

NASA Astrophysics Data System (ADS)

Jenko, Frank

2015-11-01

It is widely recognized that turbulence is an important and fascinating frontier topic of both basic and applied plasma physics. Numerous aspects of this paradigmatic example of self-organization in nonlinear systems far from thermodynamic equilibrium remain to be better understood. Meanwhile, for both laboratory and natural plasmas, an impressive combination of new experimental and observational data, new theoretical concepts, and new computational capabilities (on the brink of the exascale era) have become available. Thus, it seems fair to say that we are currently facing a golden age of plasma turbulence research, characterized by fundamental new insights regarding the role and nature of turbulent processes in phenomena like cross-field transport, particle acceleration and propagation, plasma heating, magnetic reconnection, or dynamo action. At the same time, there starts to emerge a more unified view of this key topic of basic plasma physics, putting it into the much broader context of complex systems research and connecting it, e.g., to condensed matter physics and biophysics. I will describe recent advances and future challenges in this vibrant area of plasma physics, highlighting novel insights into the redistribution and dissipation of energy in turbulent plasmas at kinetic scales, using gyrokinetic, hybrid, and fully kinetic approaches in a complementary fashion. In this context, I will discuss, among other things, the influence of damped eigenmodes, the importance of nonlocal interactions, the origin and nature of non-universal power law spectra, as well as the role of coherent structures. Moreover, I will outline exciting new research opportunities on the horizon, combining extreme scale simulations with basic plasma and fusion experiments as well as with observations from satellites.

Skin Cancers of the Feet

MedlinePlus

... and Reimbursement Basics APMA Career Center Your APMA Leadership Opportunities Early Career Resources Academic and Scientific Resources Practice Management & Reimbursement Coding Resources Coding Resource Center Reimbursement Resources ...

Cutting power costs starts with basic analyses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Paik, M.

1996-10-07

Oil and gas production departments should already be reducing their power costs. Regardless of how US deregulation of electricity finally shakes out, power costs are a large portion of total operating expense. Much has been written in recent months about the rosy days, ahead, when electric utilities will be fully deregulated. But this will only be an extension of the opportunities available today; although, after deregulation, many new options will add both opportunities along with complexities. There is no magic to reducing power costs. It is simply a matter of working at it. Recommended steps for lowering power costs ismore » shown. The paper discusses electricity basics, power bills, managing power cost, field equipment changes, electrical equipment changes and deregulation.« less

Space Rocks Tell Their Secrets: Space Science Applications of Physics and Chemistry for High School and College Classes. Update.

NASA Technical Reports Server (NTRS)

Lindstrom, M. M.; Tobola, K. W.; Allen, J. S.; Stocco, K.; Henry, M.; Allen, J. S.; McReynolds, Julie; Porter, T. Todd; Veile, Jeri

2005-01-01

As the scientific community studies Mars remotely for signs of life and uses Martian meteorites as its only available samples, teachers, students, and the general public continue to ask, "How do we know these meteorites are from Mars?" This question sets the stage for a six-lesson instructional package Space Rocks Tell Their Secrets. Expanding on the short answer "It's the chemistry of the rock", students are introduced to the research that reveals the true identities of the rocks. Since few high school or beginning college students have the opportunity to participate in this level of research, a slide presentation introduces them to the labs, samples, and people involved with the research. As they work through the lessons and interpret authentic data, students realize that the research is an application of two basic science concepts taught in the classroom, the electromagnetic spectrum and isotopes. Additional information is included in the original extended abstract.

The e-Poster Conference: An Online Nursing Research Course Learning Activity.

PubMed

Pierce, Linda L

2016-09-01

Posters have become one of the most important types of scientific communication. This article describes an e-poster conference as an online learning activity for professional nursing students. Research and evidence-based practice (EBP) project posters from colleagues across the country were placed on a university research course Web site, along with an evaluation tool and discussion prompts. During one semester, students experienced a range of activities focused on understanding research and EBP basic processes in preparation for evaluation and discussion of the layout and content of these e-posters. From all accounts, the conference was rated as positive, providing nursing students with opportunities to (a) view studies and projects from a wider nursing science audience, (b) foster the development of important evaluation and communication skills, and (c) be exposed to evidence that could be translated into their practice. Other schools and organizations may adopt this e-poster conference activity to stimulate professional nurses' critical thinking ability. [J Nurs Educ. 2016;55(9):533-535.]. Copyright 2016, SLACK Incorporated.

Neuroimaging in mental health care: voices in translation

PubMed Central

Borgelt, Emily L.; Buchman, Daniel Z.; Illes, Judy

2012-01-01

Images of brain function, popularly called “neuroimages,” have become a mainstay of contemporary communication about neuroscience and mental health. Paralleling media coverage of neuroimaging research and the high visibility of clinics selling scans is pressure from sponsors to move basic research about brain function along the translational pathway. Indeed, neuroimaging may offer benefits to mental health care: early or tailored intervention, opportunities for education and planning, and access to resources afforded by objectification of disorder. However, risks of premature technology transfer, such as misinterpretation, misrepresentation, and increased stigmatization, could compromise patient care. The insights of stakeholder groups about neuroimaging for mental health care are a largely untapped resource of information and guidance for translational efforts. We argue that the insights of key stakeholders—including researchers, healthcare providers, patients, and families—have an essential role to play upstream in professional, critical, and ethical discourse surrounding neuroimaging in mental health. Here we integrate previously orthogonal lines of inquiry involving stakeholder research to describe the translational landscape as well as challenges on its horizon. PMID:23097640

Psychiatry chief resident opinions toward basic and clinical neuroscience training and practice.

PubMed

Bennett, Jeffrey I; Handa, Kamna; Mahajan, Aman; Deotale, Pravesh

2014-04-01

The authors queried attendees to a chief resident conference on whether program education and training in neuroscience or in translating neuroscience research into practice is sufficient and what changes are needed. The authors developed and administered a 26-item voluntary questionnaire to each attendee at the Chief Residents' Leadership Conference at the American Psychiatric Association 2013 annual meeting in San Francisco, CA. Out of 94 attendees, 55 completed and returned questionnaires (58.5%). A majority of respondents stated that their program provided adequate training in neuroscience (61.8%); opportunities for neuroscience research existed for them (78.2%), but that their program did not prepare them for translating future neuroscience research findings into clinical practice (78.9%) or educate them on the NIMH Research Domain Criteria (83.3%). A majority of respondents stated that the ACGME should require a specific neuroscience curriculum (79.6%). Chief residents believe that curricular and cultural change is needed in psychiatry residency neuroscience education.

32 CFR 272.3 - Definition of basic research.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Definition of basic research. 272.3 Section 272...) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.3 Definition of basic research. Basic research is systematic study directed toward greater knowledge or understanding of...

32 CFR 272.3 - Definition of basic research.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Definition of basic research. 272.3 Section 272...) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.3 Definition of basic research. Basic research is systematic study directed toward greater knowledge or understanding of...

Comparision of alternatively certified and traditionally certified Missouri high school science teachers' perceptions of self-efficacy during the induction period

NASA Astrophysics Data System (ADS)

Gaither, Linda

Sixty percent of America's teachers choose traditional baccalaureate programs while the remaining choose one of several alternative pathways. While certification/training is certainly important to preparing effective teachers, other research indicates that teacher efficacy serves as the foundation of teacher behaviors and classroom practice. The purpose of this study ( N = 94 induction high school science teachers) was to determine the relationships between certification pathway and opportunities to observe modeling; between years of experience and personal teaching efficacy; and teachers' perceptions of what characteristics/ experiences best explain personal teaching efficacy. The Teacher Sense of Efficacy Scale was used in an on-line survey for Phase 1 (n = 91), to measure teacher self-efficacy. In Phase 2, a basic qualitative study was conducted using telephone interviews ( n = 2) and a focus group (n = 4) along with a series of short essay questions from the online survey (n = 91). The findings indicate a significant relationship (p = 0.01) between years of teaching and overall personal teaching-efficacy, student engagement, and instructional strategies; a relationship between opportunities to see modeling and certification pathway, where traditionally certified teachers had significantly more opportunities (p = 0.000); and a relationship between classroom management and opportunities to see modeling (p = 0.005). Qualitative analyses confirmed that traditionally-prepared teachers saw a range of "modeling" and model teachers; respondents related such opportunities to more effective teaching, especially in the realm of classroom management. As more teachers choose alternative certification, it is imperative that adequate opportunities to observe teaching strategies are modeled during the certification process and once teachers enter the classroom; they must have intrinsic and extrinsic support to be successful.

Medical Research Volunteer Program (MRVP): innovative program promoting undergraduate research in the medical field.

PubMed

Dagher, Michael M; Atieh, Jessica A; Soubra, Marwa K; Khoury, Samia J; Tamim, Hani; Kaafarani, Bilal R

2016-06-06

Most educational institutions lack a structured system that provides undergraduate students with research exposure in the medical field. The objective of this paper is to describe the structure of the Medical Research Volunteer Program (MRVP) which was established at the American University of Beirut, Lebanon, as well as to assess the success of the program. The MRVP is a program that targets undergraduate students interested in becoming involved in the medical research field early on in their academic career. It provides students with an active experience and the opportunity to learn from and support physicians, clinical researchers, basic science researchers and other health professionals. Through this program, students are assigned to researchers and become part of a research team where they observe and aid on a volunteer basis. This paper presents the MRVP's four major pillars: the students, the faculty members, the MRVP committee, and the online portal. Moreover, details of the MRVP process are provided. The success of the program was assessed by carrying out analyses using information gathered from the MRVP participants (both students and faculty). Satisfaction with the program was assessed using a set of questions rated on a Likert scale, ranging from 1 (lowest satisfaction) to 5 (highest satisfaction). A total of 211 students applied to the program with a total of 164 matches being completed. Since the beginning of the program, three students have each co-authored a publication in peer-reviewed journals with their respective faculty members. The majority of the students rated the program positively. Of the total number of students who completed the program period, 35.1 % rated the effectiveness of the program with a 5, 54.8 % rated 4, and 8.6 % rated 3. A small number of students gave lower ratings of 2 and 1 (1.1 % and 0.4 %, respectively). The MRVP is a program that provides undergraduate students with the opportunity to learn about research firsthand as they volunteer and aid in different research projects. This program also provides faculty members with the help to conduct their research projects and opportunity to influence future generations. It was shown that so far the MRVP has been successful in reaching its goals, for both students and faculty.

Prescription Custom Orthotics and Shoe Inserts

MedlinePlus

... and Reimbursement Basics APMA Career Center Your APMA Leadership Opportunities Early Career Resources Academic and Scientific Resources Practice Management & Reimbursement Coding Resources Coding Resource Center Reimbursement Resources ...

Simulation Research in Gastrointestinal and Urologic Care-Challenges and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Biomedical Imaging and Bioengineering Workshop.

PubMed

Aggarwal, Rajesh; Brown, Kimberly M; de Groen, Piet C; Gallagher, Anthony G; Henriksen, Kerm; Kavoussi, Louis R; Peng, Grace C Y; Ritter, E Matthew; Silverman, Elliott; Wang, Kenneth K; Andersen, Dana K

2018-01-01

: A workshop on "Simulation Research in Gastrointestinal and Urologic Care: Challenges and Opportunities" was held at the National Institutes of Health in June 2016. The purpose of the workshop was to examine the extent to which simulation approaches have been used by skilled proceduralists (not trainees) caring for patients with gastrointestinal and urologic diseases. The current status of research findings in the use and effectiveness of simulation applications was reviewed, and numerous knowledge gaps and research needs were identified by the faculty and the attendees. The paradigm of "deliberate practice," rather than mere repetition, and the value of coaching by experts was stressed by those who have adopted simulation in music and sports. Models that are most useful for the adoption of simulation by expert clinicians have yet to be fully validated. Initial studies on the impact of simulation on safety and error reduction have demonstrated its value in the training domain, but the role of simulation as a strategy for increased procedural safety remains uncertain in the world of the expert practitioner. Although the basic requirements for experienced physicians to acquire new skills have been explored, the widespread availability of such resources is an unrealized goal, and there is a need for well-designed outcome studies to establish the role of simulation in improving the quality of health care.

Integrated Research and Capacity Building in Geophysics

NASA Astrophysics Data System (ADS)

Willemann, R. J.; Lerner-Lam, A.; Nyblade, A.

2008-05-01

There have been special opportunities over the past several years to improve the ways that newly-constructed geophysical observatories in Southeast Asia and the Americas are linked with educational and civil institutions. Because these opportunities have been only partially fulfilled, there remains the possibility that new networks will not fully address desired goals or even lose operational capabilities. In contrast, the AfricaArray project continues to progress towards goals for linkages among education, research, mitigation and observatories. With support from the Office of International Science and Education at the US National Science Foundation, we convened a workshop to explore lessons learned from the AfricaArray experience and their relevance to network development opportunities in other regions. We found closer parallels than we expected between geophysical infrastructure in the predominantly low income countries of Africa with low risk of geophysical disasters and the mostly middle-income countries of Southeast Asia and the Americas with high risk of geophysical disasters. Except in larger countries of South America, workshop participants reported that there are very few geophysicists engaged in research and observatory operations, that geophysical education programs are nearly non-existent even at the undergraduate university level, and that many monitoring agencies continue to focus on limited missions even though closer relationships researchers could facilitate new services that would make important contributions to disaster mitigation and sustainable operations. Workshop participants began discussing plans for international research collaborations that, unlike many projects of even the recent past, would include long-term capacity building and disaster mitigation among their goals. Specific project objectives would include national or regional hazard mapping, development of indigenous education programs, training to address the needs of local monitoring agencies, strategic international university partnerships, commitments to open data, and installation of permanent analysis systems that include open- source software. Such projects are intrinsically more complex than pure research - partly because they require funding from multiple sources to address diverse goals - but experience in Africa suggests that integrated programs contribute to long-term capacity building in ways that projects founded on basic research questions may not.

Vulnerability as a key to authenticity.

PubMed

Daniel, L E

1998-01-01

Vulnerability is explored as a human trait that gives nurses an opportunity to engage in authentic nursing. Vulnerability in both nurse and patient is necessary for the practice of nursing with caring as its basic premise. Philosophic discourse. Vulnerability is explored in terms of its traditional connotation and existential meaning. To be authentic, nurses must be aware of their own vulnerability, recognize themselves in others, and be willing to enter into mutual vulnerability. If nurses deny the opportunity to be vulnerable, they deny the opportunity to participate in humanness and are more likely to dehumanize others.

Breast Cancer Subtypes: Morphologic and Biologic Characterization

PubMed Central

2016-01-01

Advances in basic science, technology and translational research have created a revolution in breast cancer diagnosis and therapy. Researchers' discoveries of genes defining variability in response to therapy and heterogeneity in clinical presentations and tumor biology are the foundation of the path to personalized medicine. The success of personalized breast cancer care depends on access to pertinent clinical information and risk factors, optimal imaging findings, well-established morphologic features, and traditional and contemporary prognostic/predictive testing. The integration of these entities provides an opportunity to identify patients who can benefit from specific therapies, and demonstrates the link between breast cancer subtypes and their association with different tumor biology. It is critical to recognize specific types of breast cancer in individual patients and design optimal personalized therapy. This article will highlight the roles of morphologic features and established tumor biomarkers on patient outcome. PMID:26756229

Designing Interventions Informed by Scientific Knowledge About Effects of Early Adversity: A Translational Neuroscience Agenda for Next Generation Addictions Research

PubMed Central

Fisher, Philip A.; Berkman, Elliot T.

2015-01-01

In spite of extensive scientific knowledge about the neurobiological systems and neural pathways underlying addictions, only limited progress has been made to reduce the population-level incidence of addictions by using prevention and treatment programs. In this area of research the translation of basic neuroscience of causal mechanisms to effective interventions has not been fully realized. In this article we describe how an understanding of the effects of early adverse experiences on brain and biological development may provide new opportunities to achieve impact at scale with respect to reduction of addictions. We propose four categories of new knowledge that translational neuroscience investigations of addictions should incorporate to be successful. We then describe a translational neuroscience-informed smoking cessation intervention based on this model. PMID:26985399

Challenges and New Opportunities for Clinical Nutrition Interventions in the Aged123

PubMed Central

Johnson, Mary Ann; Dwyer, Johanna T.; Jensen, Gordon L.; Miller, Joshua W.; Speakman, John R.; Starke-Reed, Pamela; Volpi, Elena

2011-01-01

Nutritional status plays a critical role in the prevention and management of many chronic health conditions that are common in the elderly and are likely to become more prevalent as the population ages. This paper highlights several aspects of nutrition that require additional basic science and clinical application research to improve the health and well-being of older adults. Topics addressed are selected demographic and health indices, the uncertain benefits of energy restriction in aged humans compared with other species, the impact of food insecurity on health, the relationship between dietary protein and sarcopenia, the prevention and management of obesity while maintaining muscle mass and functional status, and controversy regarding high intakes of folic acid. Research needs regarding the safety, efficacy, and application of clinical interventions related to these topics also are discussed. PMID:21270372

Mission Possible: BioMedical Experiments on the Space Shuttle

NASA Technical Reports Server (NTRS)

Bopp, E.; Kreutzberg, K.

2011-01-01

Biomedical research, both applied and basic, was conducted on every Shuttle mission from 1981 to 2011. The Space Shuttle Program enabled NASA investigators and researchers from around the world to address fundamental issues concerning living and working effectively in space. Operationally focused occupational health investigations and tests were given priority by the Shuttle crew and Shuttle Program management for the resolution of acute health issues caused by the rigors of spaceflight. The challenges of research on the Shuttle included: limited up and return mass, limited power, limited crew time, and requirements for containment of hazards. The sheer capacity of the Shuttle for crew and equipment was unsurpassed by any other launch and entry vehicle and the Shuttle Program provided more opportunity for human research than any program before or since. To take advantage of this opportunity, life sciences research programs learned how to: streamline the complicated process of integrating experiments aboard the Shuttle, design experiments and hardware within operational constraints, and integrate requirements between different experiments and with operational countermeasures. We learned how to take advantage of commercial-off-the-shelf hardware and developed a hardware certification process with the flexibility to allow for design changes between flights. We learned the importance of end-to-end testing for experiment hardware with humans-in-the-loop. Most importantly, we learned that the Shuttle Program provided an excellent platform for conducting human research and for developing the systems that are now used to optimize research on the International Space Station. This presentation will include a review of the types of experiments and medical tests flown on the Shuttle and the processes that were used to manifest and conduct the experiments. Learning Objective: This paper provides a description of the challenges related to launching and implementing biomedical experiments aboard the Space Shuttle.

Digital and social media opportunities for dietary behaviour change.

PubMed

McGloin, Aileen F; Eslami, Sara

2015-05-01

The way that people communicate, consume media and seek and receive information is changing. Forty per cent of the world's population now has an internet connection, the average global social media penetration is 39% and 1·5 billion people have internet access via mobile phone. This large-scale move in population use of digital, social and mobile media presents an unprecedented opportunity to connect with individuals on issues concerning health. The present paper aims to investigate these opportunities in relation to dietary behaviour change. Several aspects of the digital environment could support behaviour change efforts, including reach, engagement, research, segmentation, accessibility and potential to build credibility, trust, collaboration and advocacy. There are opportunities to influence behaviour online using similar techniques to traditional health promotion programmes; to positively affect health-related knowledge, skills and self-efficacy. The abundance of data on citizens' digital behaviours, whether through search behaviour, global positioning system tracking, or via demographics and interests captured through social media profiles, offer exciting opportunities for effectively targeting relevant health messages. The digital environment presents great possibilities but also great challenges. Digital communication is uncontrolled, multi-way and co-created and concerns remain in relation to inequalities, privacy, misinformation and lack of evaluation. Although web-based, social-media-based and mobile-based studies tend to show positive results for dietary behaviour change, methodologies have yet to be developed that go beyond basic evaluation criteria and move towards true measures of behaviour change. Novel approaches are necessary both in the digital promotion of behaviour change and in its measurement.

COLORADO STATE PLAN FOR ADULT BASIC EDUCATION UNDER PROVISIONS OF ADULT EDUCATION ACT OF 1966 (PL 89-750, NOV 3, 1966).

ERIC Educational Resources Information Center

Colorado State Dept. of Education, Denver.

LACK OF FINANCES, QUALIFIED PERSONNEL, AND TRAINING OPPORTUNITIES IN INSTITUTIONS OF HIGHER LEARNING MADE THE PROBLEMS OF EDUCATING THE 250,000 COLORADO ADULTS WITH LESS THAN EIGHT YEARS OF FORMAL SCHOOLING DIFFICULT TO ATTACK. UNDER THE ECONOMIC OPPORTUNITY ACT OF 1964, A COOPERATIVE EFFORT WAS BEGUN BY SCHOOL DISTRICTS AND OTHER AGENCIES TO…

Opportunities to Learn in School and at Home: How Can They Predict Students' Understanding of Basic Science Concepts and Principles?

ERIC Educational Resources Information Center

Wang, Su; Liu, Xiufeng; Zhao, Yandong

2012-01-01

As the breadth and depth of economic reforms increase in China, growing attention is being paid to equalities in opportunities to learn science by students of various backgrounds. In early 2009, the Chinese Ministry of Education and Ministry of Science and Technology jointly sponsored a national survey of urban eighth-grade students' science…

Changing Perspectives and Opportunities and Their Impact on Careers and Aspirations: The Case of Women Lawyers.

ERIC Educational Resources Information Center

Epstein, Cynthia Fuchs

Change in the roles of women in American society during the past 15 years provides an opportunity to evaluate basic theories dealing with life course, the impact of early socialization, and trait analysis. The case of women in the legal profession is of particular value in exploring these issues since law, an exclusively male domain for more than…

Comments on "Opportunity Cost: A Reexamination": A Case in Point of No Free Lunch

ERIC Educational Resources Information Center

Stone, Daniel F.

2016-01-01

Ferraro and Taylor (2005) and Potter and Sanders (2012) have sparked a debate about the definition of opportunity cost (OC). This is, of course, ostensibly a very basic term, but Ferraro and Taylor said that most economists do not readily know its correct definition, and Potter and Sanders argued that this can be explained by the fact that there…

The Potential of Community Colleges as Bridges to Opportunity for the Disadvantaged: Can It Be Achieved on a Large Scale?

ERIC Educational Resources Information Center

Jenkins, Davis

This paper analyzes the role the community college plays as a bridge to opportunity for the working poor and economically disadvantaged. Because educating the disadvantaged is expensive and often under-funded--particularly in the area of basic or remedial education--many community colleges opt to focus on educating more advantaged students in…

Bundling Logging Residues with a Modified John Deere B-380 Slash Bundler

Treesearch

Dana Mitchell

2011-01-01

A basic problem with processing biomass in the woods is that the machinery must be matched to the final product. If a logging business owner invests in a machine to produce a specific type of biomass product for a limited market, the opportunity for that logging business owner to diversify products to take advantage of market opportunities may also be limited. When...

Stage I Final Report for the Study of Program Management Procedures in the Campus-Based and Basic Grant Programs. (Volume I).

ERIC Educational Resources Information Center

Puma, Michael J.; And Others

The third phase of SISFAP (Study on the Impact of Student Financial Aid Programs), the primary purpose of this study is to evaluate federal and institutional management policies and practices for Basic Educational Opportunity Grant (BEOG) and campus-based programs as they impact on the extent to which the programs are meeting their legislative…

Validation of Student and Parent Reported Data on the Basic Grant Application Form. Pre-Award Validation Analysis Study: Phases I and II Report.

ERIC Educational Resources Information Center

Applied Management Sciences, Inc., Silver Spring, MD.

A Pre-Award Validation Analysis was conducted in 1978-1979 to provide the federal government information about the accuracy of data provided by applicants for Basic Educational Opportunity Grants. New procedures involved: validation of selected applications by college financial aid officers using documentation such as Federal Income Tax forms;…

Will the Pell Grant Have the Ability To Provide Access and Choice to Low-Income Students in the Future?

ERIC Educational Resources Information Center

Lechuga, Vicente M.

This paper provides a basic understanding of the Pell Grant program and summarizes the evidence regarding its effectiveness. The Basic Educational Opportunities Program, known as the Pell Grant program, began in 1973 as a means of providing disadvantaged students access to a postsecondary education. The Pell Grant program has tried to keep up with…

Five strategies for accelerating the war on cancer in an era of budget deficits.

PubMed

Doroshow, James H; Croyle, Robert T; Niederhuber, John E

2009-02-01

In recent years, the National Institutes of Health's largest institute, the National Cancer Institute (NCI), has adapted to difficult economic conditions by leveraging its robust infrastructure -- which includes risk factor surveillance and population monitoring, research centers (focused on basic, translation, clinical, and behavioral sciences), clinical trials and health care research networks, and rigorously validated statistical models -- to maximize the impact of scientific progress on the public health. To continue advancement and realize the opportunity of significant, population-level changes in cancer mortality, the NCI recommends that five national-level actions be taken: (1) significantly increase enrollment of Medicare patients into cancer clinical trials through adequate physician reimbursement, (2) increase NCI/Centers for Medicare and Medicaid Services collaboration on clinical trials research to evaluate the therapeutic efficacy of anticancer drugs, (3) establish a national outcomes research demonstration project to test strategies for measuring and improving health care quality and provide an evidence base for public policy, (4) leverage existing tobacco-control collaborations and possible new authorities at the U.S. Food and Drug Administration to realize the outstanding health gains possible from a reduction in tobacco use, and (5) increase colorectal cancer screening rates though intensified collaboration between federal agencies working to address barriers to access and use of screening. These cost-effective strategies provide the opportunity for extraordinary results in an era of budget deficits. Of the chronic diseases, cancer has the strongest national research infrastructure that can be leveraged to produce rapid results to inform budget prioritization and public policy, as well as mobilize new projects to answer critical public health questions.

Evaluating the federal role in financing health-related research

PubMed Central

Garber, Alan M.; Romer, Paul M.

1996-01-01

This paper considers the appropriate role for government in the support of scientific and technological progress in health care; the information the federal government needs to make well-informed decisions about its role; and the ways that federal policy toward research and development should respond to scientific advances, technology trends, and changes in the political and social environment. The principal justification for government support of research rests upon economic characteristics that lead private markets to provide inappropriate levels of research support or to supply inappropriate quantities of the products that result from research. The federal government has two basic tools for dealing with these problems: direct subsidies for research and strengthened property rights that can increase the revenues that companies receive for the products that result from research. In the coming years, the delivery system for health care will continue to undergo dramatic changes, new research opportunities will emerge at a rapid pace, and the pressure to limit discretionary federal spending will intensify. These forces make it increasingly important to improve the measurement of the costs and benefits of research and to recognize the tradeoffs among alternative policies for promoting innovation in health care. PMID:8917484

Opportunities for electricity storage in deregulating markets

DOE Office of Scientific and Technical Information (OSTI.GOV)

Graves, F.; Jenkin, T.; Murphy, D.

1999-10-01

This article addresses the value of electricity storage and its ability to take advantage of emerging energy arbitrage opportunities: buying power when it is inexpensive, and reselling it at a higher price. The focus of this article is on electricity markets and the opportunities they present for a merchant storage device, rather than on storage technologies themselves. There are a number of existing and emerging storage technologies: pumped hydro, various batteries, compressed air energy storage (CAES), superconducting magnetic energy storage (SMES), flywheels--even conventional hydro has storage-like properties. However, all these technologies operated on the same basic principle of exploiting short-termmore » differentials in electricity prices: buy low, sell high (a strategy that is actually meaningful in electricity markets, unlike in financial markets). The object of this article is to develop and demonstrate a means for assessing the potential value of storage in different electricity markets, rather than to attempt to assess the prospects of a particular technology. The approach taken here is to look at price data from a number of actual electricity markets to determine what opportunities they might offer to a generic storage device. A storage technology is described here by its basic performance parameters--charge and generate capacity, energy inventory limits, and efficiency--which are sufficient to assess the basic economic potential of storage in a given market. The authors look primarily at US markets, but also compare and contrast findings with the situation in foreign markets in the U.K., Norway, Canada, and Australia, and discuss how market structure can influence the value of storage. Moreover, the authors use empirically observed relationships between hourly and 5 x 16 blocked prices to infer a rule for adjusting the value of storage assets in regions where only blocked price information is available.« less

Physicists in the Wild

NASA Astrophysics Data System (ADS)

Miller, Michael L.

2017-09-01

Startups and large corporations are full of physicists, many hiding in plain sight. Why? I will discuss the strong parallels between basic research in nuclear/particle physics, founding teams at great startups, and leaders at some of the world's largest corporations. How big are these opportunities (mission and capital), and what can we do to help prepare more physicists for such roles? I will provide lessons learned from my winding career that began at the NSCL as a philosophy undergrad, proceeded through a PhD, postdoc and brief stint as faculty, and continued through the founding of an early cloud computing startup, a sale to IBM, and the founding of one of Silicon Valley's most active venture capital firms.

Past, present and future of spike sorting techniques

PubMed Central

Rey, Hernan Gonzalo; Pedreira, Carlos; Quian Quiroga, Rodrigo

2015-01-01

Spike sorting is a crucial step to extract information from extracellular recordings. With new recording opportunities provided by the development of new electrodes that allow monitoring hundreds of neurons simultaneously, the scenario for the new generation of algorithms is both exciting and challenging. However, this will require a new approach to the problem and the development of a common reference framework to quickly assess the performance of new algorithms. In this work, we review the basic concepts of spike sorting, including the requirements for different applications, together with the problems faced by presently available algorithms. We conclude by proposing a roadmap stressing the crucial points to be addressed to support the neuroscientific research of the near future. PMID:25931392

Determining The Various Perspectives And Consensus Within A Classroom Using Q Methodology

NASA Astrophysics Data System (ADS)

Ramlo, Susan E.

2008-10-01

Q methodology was developed by PhD physicist and psychologist William Stevenson 73 years ago as a new way of investigating people's views of any topic. Yet its application has primarily been in the fields of marketing, psychology, and political science. Still, Q offers an opportunity for the physics education research community to determine the perspectives and consensus within a group, such as a classroom, related to topics of interest such as the nature of science and epistemology. This paper presents the basics of using Q methodology with a classroom application as an example and subsequent comparisons of this example's results to similar studies using qualitative and survey methods.

SWOT analysis of Banff: strengths, weaknesses, opportunities and threats of the international Banff consensus process and classification system for renal allograft pathology.

PubMed

Mengel, M; Sis, B; Halloran, P F

2007-10-01

The Banff process defined the diagnostic histologic lesions for renal allograft rejection and created a standardized classification system where none had existed. By correcting this deficit the process had universal impact on clinical practice and clinical and basic research. All trials of new drugs since the early 1990s benefited, because the Banff classification of lesions permitted the end point of biopsy-proven rejection. The Banff process has strengths, weaknesses, opportunities and threats (SWOT). The strength is its self-organizing group structure to create consensus. Consensus does not mean correctness: defining consensus is essential if a widely held view is to be proved wrong. The weaknesses of the Banff process are the absence of an independent external standard to test the classification; and its almost exclusive reliance on histopathology, which has inherent limitations in intra- and interobserver reproducibility, particularly at the interface between borderline and rejection, is exactly where clinicians demand precision. The opportunity lies in the new technology such as transcriptomics, which can form an external standard and can be incorporated into a new classification combining the elegance of histopathology and the objectivity of transcriptomics. The threat is the degree to which the renal transplant community will participate in and support this process.

32 CFR Appendix A to Part 272 - Principles for the Conduct and Support of Basic Research

Code of Federal Regulations, 2010 CFR

2010-07-01

... Research A Appendix A to Part 272 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE... Research 1. Basic research is an investment. The DoD Components are to view and manage basic research...

Light Activated Escape Circuits: A Behavior and Neurophysiology Lab Module using Drosophila Optogenetics

PubMed Central

Titlow, Josh S.; Johnson, Bruce R.; Pulver, Stefan R.

2015-01-01

The neural networks that control escape from predators often show very clear relationships between defined sensory inputs and stereotyped motor outputs. This feature provides unique opportunities for researchers, but it also provides novel opportunities for neuroscience educators. Here we introduce new teaching modules using adult Drosophila that have been engineered to express csChrimson, a red-light sensitive channelrhodopsin, in specific sets of neurons and muscles mediating visually guided escape behaviors. This lab module consists of both behavior and electrophysiology experiments that explore the neural basis of flight escape. Three preparations are described that demonstrate photo-activation of the giant fiber circuit and how to quantify these behaviors. One of the preparations is then used to acquire intracellular electrophysiology recordings from different flight muscles. The diversity of action potential waveforms and firing frequencies observed in the flight muscles make this a rich preparation to study the ionic basic of cellular excitability. By activating different cells within the giant fiber pathway we also demonstrate principles of synaptic transmission and neural circuits. Beyond conveying core neurobiological concepts it is also expected that using these cutting edge techniques will enhance student motivation and attitudes towards biological research. Data collected from students and educators who have been involved in development of the module are presented to support this notion. PMID:26240526

Planetary Nebulae: Reviews and Previews of a Rapidly Evolving Field

NASA Astrophysics Data System (ADS)

Balick, Bruce

2015-01-01

Observational results from the ground and space in the past decade and covering the entire spectrum have jolted and energized research into the nature, the formation, and the evolution of planetary nebulae (PNs). The 101-level bubble structure of PNs turned out to be a pleasant but misleading fantasy as observations by HST and ALMA revealed basic details of their infancy. Some combination of close geriatric binary stars (the precusrors of SN Ia's) and magnetic fields dredged into the dusty winds appear to play vital roles in the ejection and collimation of AGB atmospheres. As a result, PNe and their antecedents, AGB stars and prePNs, are providing an array of new opportunities to study asymmetric wind formation, complex gas dynamics, CNO production rates in various galactic environments, and galaxy structure and evolution. I shall review the highlights of recent results, summarize their interpretations, and show some of the observational opportunities to monitor in the next decade, many of which couple strongly to research to related fields.This talk is dedicated to the career of Olivier Chesneau (1972-2014) who pioneered new high-resolution imaging methods that peered into the deep inner cores of nascent planetary nebulae. We remember Olivier as everyone's enthusiastic friend and colleague whose career ended in full stride.

XXV IUPAP Conference on Computational Physics (CCP2013): Preface

NASA Astrophysics Data System (ADS)

2014-05-01

XXV IUPAP Conference on Computational Physics (CCP2013) was held from 20-24 August 2013 at the Russian Academy of Sciences in Moscow, Russia. The annual Conferences on Computational Physics (CCP) present an overview of the most recent developments and opportunities in computational physics across a broad range of topical areas. The CCP series aims to draw computational scientists from around the world and to stimulate interdisciplinary discussion and collaboration by putting together researchers interested in various fields of computational science. It is organized under the auspices of the International Union of Pure and Applied Physics and has been in existence since 1989. The CCP series alternates between Europe, America and Asia-Pacific. The conferences are traditionally supported by European Physical Society and American Physical Society. This year the Conference host was Landau Institute for Theoretical Physics. The Conference contained 142 presentations, and, in particular, 11 plenary talks with comprehensive reviews from airbursts to many-electron systems. We would like to take this opportunity to thank our sponsors: International Union of Pure and Applied Physics (IUPAP), European Physical Society (EPS), Division of Computational Physics of American Physical Society (DCOMP/APS), Russian Foundation for Basic Research, Department of Physical Sciences of Russian Academy of Sciences, RSC Group company. Further conference information and images from the conference are available in the pdf.

Summer Schools in Nuclear and Radiochemistry

DOE Office of Scientific and Technical Information (OSTI.GOV)

Silber, Herbert B.

The ACS Summer Schools in Nuclear and Radiochemistry (herein called “Summer Schools”) were funded by the U.S. Department of Energy and held at San Jose State University (SJSU) and Brookhaven National Laboratory (BNL). The Summer Schools offer undergraduate students with U.S. citizenship an opportunity to complete coursework through ACS accredited chemistry degree programs at SJSU or the State University of New York at Stony Brook (SBU). The courses include lecture and laboratory work on the fundamentals and applications of nuclear and radiochemistry. The number of students participating at each site is limited to 12, and the low student-to-instructor ratio ismore » needed due to the intense nature of the six-week program. To broaden the students’ perspectives on nuclear science, prominent research scientists active in nuclear and/or radiochemical research participate in a Guest Lecture Series. Symposia emphasizing environmental chemistry, nuclear medicine, and career opportunities are conducted as a part of the program. The Department of Energy’s Office of Basic Energy Sciences (BES) renewed the five-year proposal for the Summer Schools starting March 1, 2007, with contributions from Biological and Environmental Remediation (BER) and Nuclear Physics (NP). This Final Technical Report covers the Summer Schools held in the years 2007-2011.« less

Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: Formulation development, stability issues, basic considerations and applications.

PubMed

Rai, Vineet Kumar; Mishra, Nidhi; Yadav, Kuldeep Singh; Yadav, Narayan Prasad

2018-01-28

The use of nanoemulsion in augmenting dermal and transdermal effectiveness of drugs has now well established. The development of nanoemulsion based semisolid dosage forms is an active area of present research. However, thickening or liquid-to-semisolid conversion of the nanoemulsions provides opportunities to the formulation scientist to explore novel means of solving instability issues during transformation. Extending knowledge about the explicit role of nature/magnitude of zeta potential, types of emulsifiers and selection of appropriate semisolid bases could place these versatile carriers from laboratory to industrial scale. This article reviews the progressive advancement in the delivery of medicament via nanoemulsion with special reference to the dermal and transdermal administration. It is attempted to explore the most suitable semi solid dosage form for the particular type of nanoemulsion (o/w, w/o and others) and effect of particle size and zeta potential on the delivery of drugs through dermal or transdermal route. Finally, this review also highlights the basic principles and fundamental considerations of nanoemulsion manufacture, application of nanoemulsion based semisolid dosage forms in the dermal/transdermal administration and basic considerations during the nanoemulsion absorption into and through skin. Copyright © 2017 Elsevier B.V. All rights reserved.

Conference Comments by the Editors

NASA Astrophysics Data System (ADS)

Novotny, Rainer; Nikl, Martin; Williams, Richard T.; Auffray, Etiennette; Dorenbos, Pieter; Dujardin, Christophe; era, Miroslav Ku c.˘; Mihóková, Eva; Wojtowicz, Andrzej J.

2012-10-01

The SCINT series of conferences on Inorganic Scintillators and their Applications has provided, beginning in 1992, a regular platform for researchers from all over the world working in this field. This conference merges the aspects of basic science with application-related issues in the field of inorganic scintillators and phosphors and provides unique opportunities for both scientists and engineers to exchange their new results and ideas. Previous SCINT conferences were held first in Chamonix in 1992 and then in San Francisco, Delft, Shanghai, Moscow, Chamonix, Valencia, Alushta, Winston- Salem, and Jeju Island in Korea in 2009. The most recent, the 11th International Conference on Inorganic Scintillators and their Applications (SCINT 2011), was held at the Science Campus of Justus Liebig University, Giessen, Germany, September 11¿16, 2011. There were a total 187 scientific contributions, 82 oral presentations, 19 invited talks, and 105 poster exhibitions presented by 235 participants from 24 different countries. For the first time, a pre-conference tutorial was organized, which covered the basic physics of scintillation mechanisms as well as the wide field of applications. The purpose was mainly to educate students and newcomers in the field. This special issue of the IEEE TRANSACTIONS ON NUCLEAR SCIENCE comprises the refereed proceedings of SCINT 2011, containing 61 papers on the research presentations.

Implications of learning theory for developing programs to decrease overeating.

PubMed

Boutelle, Kerri N; Bouton, Mark E

2015-10-01

Childhood obesity is associated with medical and psychological comorbidities, and interventions targeting overeating could be pragmatic and have a significant impact on weight. Calorically dense foods are easily available, variable, and tasty which allows for effective opportunities to learn to associate behaviors and cues in the environment with food through fundamental conditioning processes, resulting in measurable psychological and physiological food cue reactivity in vulnerable children. Basic research suggests that initial learning is difficult to erase, and that it is vulnerable to a number of phenomena that will allow the original learning to re-emerge after it is suppressed or replaced. These processes may help explain why it may be difficult to change food cue reactivity and overeating over the long term. Extinction theory may be used to develop effective cue-exposure treatments to decrease food cue reactivity through inhibitory learning, although these processes are complex and require an integral understanding of the theory and individual differences. Additionally, learning theory can be used to develop other interventions that may prove to be useful. Through an integration of learning theory, basic and translational research, it may be possible to develop interventions that can decrease the urges to overeat, and improve the weight status of children. Copyright © 2015 Elsevier Ltd. All rights reserved.

An investigation of bacterial protein interactions as a primary research project in a sophomore-level molecular biology course.

PubMed

Cardinale, Jean A

2011-01-01

Longer term research activities that may be incorporated in undergraduate courses are a powerful tool for promoting student interest and learning, developing cognitive process skills, and allowing undergraduates to experience real research activities in which they may not otherwise have the opportunity to participate. The challenge to doing so in lower-level courses is that students may have not fully grasped the scientific concepts needed to undertake such research endeavors, and that they may be discouraged if activities are perceived to be too challenging. The paper describes how a bacterial protein:protein interaction detection system was adapted and incorporated into the laboratory component of a sophomore-level Molecular Cell Biology course. The project was designed to address multiple learning objectives connecting course content to the laboratory activities, as well as teach basic molecular biology laboratory skills and procedures in the context of a primary research activity. Pre- and posttesting and student surveys both suggest that the laboratory curriculum resulted in significant learning gains, as well as being well received and valued by the students.

Assessment of programs in space biology and medicine

NASA Technical Reports Server (NTRS)

1991-01-01

Over the past 30 or more years, the National Research Council Space Studies Board and its various committees have published hundreds of recommendations concerning life sciences research. Several particularly noteworthy themes appear consistently: (1) Balance - the need for a well-balanced research program in terms of ground versus flight, basic versus clinical, and internal versus extramural; (2) Excellence - because of the extremely limited number of flight opportunities (as well as their associated relative costs), the need for absolute excellence in the research that is conducted, in terms of topic, protocol, and investigator, and (3) Facilities - the single most important facility for life sciences research in space, an on-board, variable force centrifuge. In this first assessment report, the Committee on Space Biology and Medicine emphasizes that these long-standing themes remain as essential today as when first articulated. On the brink of the twenty-first century, the nation is contemplating the goal of human space exploration; consequently, the themes bear repeating. Each is a critical component of what will be necessary to successfully achieve such a goal.

Think globally, research locally: paradigms and place in agroecological research.

PubMed

Reynolds, Heather L; Smith, Alex A; Farmer, James R

2014-10-01

Conducting science for practical ends implicates scientists, whether they wish it or not, as agents in social-ecological systems, raising ethical, economic, environmental, and political issues. Considering these issues helps scientists to increase the relevance and sustainability of research outcomes. As we rise to the worthy call to connect basic research with food production, scientists have the opportunity to evaluate alternative food production paradigms and consider how our research funds and efforts are best employed. In this contribution, we review some of the problems produced by science conducted in service of industrial agriculture and its associated economic growth paradigm. We discuss whether the new concept of "ecological intensification" can rescue the industrial agriculture/growth paradigm and present an emerging alternative paradigm of decentralized, localized, biodiversity-promoting agriculture for a steady-state economy. This "custom fit" agriculture engages constructively with complex and highly localized ecosystems, and we draw from examples of published work to demonstrate how ecologists can contribute by using approaches that acknowledge local agricultural practices and draw on community participation. © 2014 Botanical Society of America, Inc.

Animal coloration research: why it matters

PubMed Central

2017-01-01

While basic research on animal coloration is the theme of this special edition, here we highlight its applied significance for industry, innovation and society. Both the nanophotonic structures producing stunning optical effects and the colour perception mechanisms in animals are extremely diverse, having been honed over millions of years of evolution for many different purposes. Consequently, there is a wealth of opportunity for biomimetic and bioinspired applications of animal coloration research, spanning colour production, perception and function. Fundamental research on the production and perception of animal coloration is contributing to breakthroughs in the design of new materials (cosmetics, textiles, paints, optical coatings, security labels) and new technologies (cameras, sensors, optical devices, robots, biomedical implants). In addition, discoveries about the function of animal colour are influencing sport, fashion, the military and conservation. Understanding and applying knowledge of animal coloration is now a multidisciplinary exercise. Our goal here is to provide a catalyst for new ideas and collaborations between biologists studying animal coloration and researchers in other disciplines. This article is part of the themed issue ‘Animal coloration: production, perception, function and application’. PMID:28533451

Animal coloration research: why it matters.

PubMed

Caro, Tim; Stoddard, Mary Caswell; Stuart-Fox, Devi

2017-07-05

While basic research on animal coloration is the theme of this special edition, here we highlight its applied significance for industry, innovation and society. Both the nanophotonic structures producing stunning optical effects and the colour perception mechanisms in animals are extremely diverse, having been honed over millions of years of evolution for many different purposes. Consequently, there is a wealth of opportunity for biomimetic and bioinspired applications of animal coloration research, spanning colour production, perception and function. Fundamental research on the production and perception of animal coloration is contributing to breakthroughs in the design of new materials (cosmetics, textiles, paints, optical coatings, security labels) and new technologies (cameras, sensors, optical devices, robots, biomedical implants). In addition, discoveries about the function of animal colour are influencing sport, fashion, the military and conservation. Understanding and applying knowledge of animal coloration is now a multidisciplinary exercise. Our goal here is to provide a catalyst for new ideas and collaborations between biologists studying animal coloration and researchers in other disciplines.This article is part of the themed issue 'Animal coloration: production, perception, function and application'. © 2017 The Author(s).

Reducing neurodevelopmental disorders and disability through research and interventions.

PubMed

Boivin, Michael J; Kakooza, Angelina M; Warf, Benjamin C; Davidson, Leslie L; Grigorenko, Elena L

2015-11-19

We define neurodevelopment as the dynamic inter-relationship between genetic, brain, cognitive, emotional and behavioural processes across the developmental lifespan. Significant and persistent disruption to this dynamic process through environmental and genetic risk can lead to neurodevelopmental disorders and disability. Research designed to ameliorate neurodevelopmental disorders in low- and middle-income countries, as well as globally, will benefit enormously from the ongoing advances in understanding their genetic and epigenetic causes, as modified by environment and culture. We provide examples of advances in the prevention and treatment of, and the rehabilitation of those with, neurodevelopment disorders in low- and middle-income countries, along with opportunities for further strategic research initiatives. Our examples are not the only possibilities for strategic research, but they illustrate problems that, when solved, could have a considerable impact in low-resource settings. In each instance, research in low- and middle-income countries led to innovations in identification, surveillance and treatment of a neurodevelopmental disorder. These innovations have also been integrated with genotypic mapping of neurodevelopmental disorders, forming important preventative and rehabilitative interventions with the potential for high impact. These advances will ultimately allow us to understand how epigenetic influences shape neurodevelopmental risk and resilience over time and across populations. Clearly, the most strategic areas of research opportunity involve cross-disciplinary integration at the intersection between the environment, brain or behaviour neurodevelopment, and genetic and epigenetic science. At these junctions a robust integrative cross-disciplinary scientific approach is catalysing the creation of technologies and interventions for old problems. Such approaches will enable us to achieve and sustain the United Nations moral and legal mandate for child health and full development as a basic global human right.

Yeast culture collections in the twenty-first century: new opportunities and challenges.

PubMed

Boundy-Mills, Kyria L; Glantschnig, Ewald; Roberts, Ian N; Yurkov, Andrey; Casaregola, Serge; Daniel, Heide-Marie; Groenewald, Marizeth; Turchetti, Benedetta

2016-07-01

The twenty-first century has brought new opportunities and challenges to yeast culture collections, whether they are long-standing or recently established. Basic functions such as archiving, characterizing and distributing yeasts continue, but with expanded responsibilities and emerging opportunities. In addition to a number of well-known, large public repositories, there are dozens of smaller public collections that differ in the range of species and strains preserved, field of emphasis and services offered. Several collections have converted their catalogues to comprehensive databases and synchronize them continuously through public services, making it easier for users worldwide to locate a suitable source for specific yeast strains and the data associated with these yeasts. In-house research such as yeast taxonomy continues to be important at culture collections. Because yeast culture collections preserve a broad diversity of species and strains within a species, they are able to make discoveries in many other areas as well, such as biotechnology, functional, comparative and evolution genomics, bioprocesses and novel products. Due to the implementation of the Convention of Biological Diversity (CBD) and the Nagoya Protocol (NP), there are new requirements for both depositors and users to ensure that yeasts were collected following proper procedures and to guarantee that the country of origin will be considered if benefits arise from a yeast's utilization. Intellectual property rights (IPRs) are extremely relevant to the current access and benefit-sharing (ABS) mechanisms; most research and development involving genetic resources and associated traditional knowledge will be subject to this topic. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Students' Constitutional Right to a Sound Basic Education: New York State's Unfinished Agenda. Part 1. A Roadmap to Constitutional Compliance Ten Years after "CFE v. State"

ERIC Educational Resources Information Center

Rebell, Michael A.; Wolff, Jessica R.

2016-01-01

Ten years have passed since New York's highest court ruled in the landmark school-funding and educational-rights case, "Campaign for Fiscal Equity (CFE) v. State of New York," that the state was violating students' constitutional right to the "opportunity for a sound basic education" and ordered significant reforms of the…

Fuel age and fire spread: Natural conditions versus opportunities for fire suppression

USGS Publications Warehouse

Halsey, Richard W.; Keeley, Jon E.; Wilson, Kit

2009-01-01

Wildfires are driven and restrained by an interplay of variables that can lead to many potential outcomes. As every wildland firefighter learns in basic training, the ability of a fire to spread is determined by three basic variables: fuel type and condition, weather, and topography. Fire suppression obviously plays a significant role in determining fire spread as well, so firefighter activity becomes an additional variable.

Validation of Student and Parent Reported Data on the Basic Grant Application Form: Pre-Award Validation Analysis Study. Revised Final Report.

ERIC Educational Resources Information Center

Applied Management Sciences, Inc., Silver Spring, MD.

The 1978-1979 pre-award institution validation process for the Basic Educational Opportunity Grant (BEOG) program was studied, based on applicant and grant recipient files as of the end of February 1979. The objective was to assess the impact of the validation process on the proper award of BEOGs, and to determine whether the criteria for…

Validation of Student and Parent Report Data on the Basic Grant Application Form. Final Report. Volume I, Individual Validation Studies: Institution Referral Study, Pre-established Criteria Study.

ERIC Educational Resources Information Center

Vogel, Ronald J.

Errors made on applications to the Basic Educational Opportunity Grant (BEOG) program were studied to determine the scope and nature of misreporting and misuse of the BEOG program. Characteristics of applicants who misreport personal and/or family financial circumstances were identified, and procedures were established to regularly screen and…

Evaluation of the state water-resources research institutes

USGS Publications Warehouse

Ertel, M.O.

1988-01-01

Water resources research institutes, as authorized by the Water Resources Research Act of 1984 (Public Law 98-242), are located in each state and in the District of Columbia, Guam, Puerto Rico , and the Virgin Islands. Public Law 98-242 mandated an onsite evaluation of each of these institutes to determine whether ' . . .the quality and relevance of its water resources research and its effectiveness as an institution for planning, conducting, and arranging for research warrant its continued support in the national interest. ' The results of these evaluations, which were conducted between September 1985 and June 1987, are summarized. The evaluation teams found that all 54 institutes are meeting the basic objectives of the authorizing legislation in that they: (1) use the grant funds to support research that addresses water problems of state and regional concern; (2) provide opportunities for training of water scientists through student involvement on research projects; and (3) promote the application of research results through preparation of technical reports and contributions to the technical literature. The differences among institutes relate primarily to degrees of effectiveness, and most often are determined by the financial, political, and geographical contexts in which the institutes function and by the quality of their leadership. (Lantz-PTT)

A case study in the use of community-based participatory research in public health nursing.

PubMed

Savage, Christine L; Xu, Yin; Lee, Rebecca; Rose, Barbara L; Kappesser, Mary; Anthony, Jean Spann

2006-01-01

There is growing demand for research using a community-based participatory (CBPR) approach. CBPR requires that the academic research team actively partner with community members and stakeholders in the entire research process. The community members are full partners with the researchers in relation to the development and implementation of the study, analysis of the data, and dissemination of the findings. The purpose of this article is to review four basic principles of CBPR and provide an example of how these CBPR principles were used in an ethnographic study related to the culture of African American infant health. In the pilot study, CBPR provided the framework for recruitment and retention of participants, ongoing data analysis, and dissemination of findings. Using CBPR provided the researchers an introduction into the selected community. Community members served as key informants about the culture of the community and provided access to potential participants. The community partners contributed to analysis of emerging themes and in the dissemination of findings to the community, stakeholders, and the scientific community. CBPR provides opportunities for community health nurse researchers to conduct research with vulnerable populations and sets the stage for implementing evidenced-based nursing interventions in the community.

An Undergraduate Course to Bridge the Gap between Textbooks and Scientific Research

PubMed Central

Wiegant, Fred; Scager, Karin; Boonstra, Johannes

2011-01-01

This article reports on a one-semester Advanced Cell Biology course that endeavors to bridge the gap between gaining basic textbook knowledge about cell biology and learning to think and work as a researcher. The key elements of this course are 1) learning to work with primary articles in order to get acquainted with the field of choice, to learn scientific reasoning, and to identify gaps in our current knowledge that represent opportunities for further research; 2) formulating a research project with fellow students; 3) gaining thorough knowledge of relevant methodology and technologies used within the field of cell biology; 4) developing cooperation and leadership skills; and 5) presenting and defending research projects before a jury of experts. The course activities were student centered and focused on designing a genuine research program. Our 5-yr experience with this course demonstrates that 1) undergraduate students are capable of delivering high-quality research designs that meet professional standards, and 2) the authenticity of the learning environment in this course strongly engages students to become self-directed and critical thinkers. We hope to provide colleagues with an example of a course that encourages and stimulates students to develop essential research thinking skills. PMID:21364103

Outcomes associated with 12 years of grant funding: the Pediatric Endocrinology Nursing Society grant program.

PubMed

Keil, Margaret F; Lipman, Terri H

2007-06-01

In 1990, the Pediatric Endocrinology Nursing Society (PENS) developed a grant program to provide funding to advance pediatric endocrinology nursing practice through basic and applied research. Minimal data exist regarding the effect of grant funding on professional development and research dissemination. The purpose of this study was to determine the extent that PENS' grant funding has resulted in professional presentations, publications, and further research funding. Nineteen grants that received funding were identified. Survey questions included whether the results of the PENS-funded study were presented, published, and resulted in subsequent funding from other sources. Outcome data were available for 11 of 18 grants (61%). All funded studies were presented at PENS conference; 55% were presented at other national or international conferences. Sixteen publications resulted from seven funded studies; 64% of PENS' funded studies led to additional funding, and 18% resulted in additional research studies. In summary, the research grant program of PENS funded 19 grants, which resulted in numerous publications, presentations, and, in some cases, additional research funding from other sources. Many grant recipients acknowledged that PENS was their first source of research funding and gave them the opportunity to become experienced in their role as clinical researchers.

An undergraduate course to bridge the gap between textbooks and scientific research.

PubMed

Wiegant, Fred; Scager, Karin; Boonstra, Johannes

2011-01-01

This article reports on a one-semester Advanced Cell Biology course that endeavors to bridge the gap between gaining basic textbook knowledge about cell biology and learning to think and work as a researcher. The key elements of this course are 1) learning to work with primary articles in order to get acquainted with the field of choice, to learn scientific reasoning, and to identify gaps in our current knowledge that represent opportunities for further research; 2) formulating a research project with fellow students; 3) gaining thorough knowledge of relevant methodology and technologies used within the field of cell biology; 4) developing cooperation and leadership skills; and 5) presenting and defending research projects before a jury of experts. The course activities were student centered and focused on designing a genuine research program. Our 5-yr experience with this course demonstrates that 1) undergraduate students are capable of delivering high-quality research designs that meet professional standards, and 2) the authenticity of the learning environment in this course strongly engages students to become self-directed and critical thinkers. We hope to provide colleagues with an example of a course that encourages and stimulates students to develop essential research thinking skills.

Synthetic biology: An emerging research field in China

PubMed Central

Pei, Lei; Schmidt, Markus; Wei, Wei

2011-01-01

Synthetic biology is considered as an emerging research field that will bring new opportunities to biotechnology. There is an expectation that synthetic biology will not only enhance knowledge in basic science, but will also have great potential for practical applications. Synthetic biology is still in an early developmental stage in China. We provide here a review of current Chinese research activities in synthetic biology and its different subfields, such as research on genetic circuits, minimal genomes, chemical synthetic biology, protocells and DNA synthesis, using literature reviews and personal communications with Chinese researchers. To meet the increasing demand for a sustainable development, research on genetic circuits to harness biomass is the most pursed research within Chinese researchers. The environmental concerns are driven force of research on the genetic circuits for bioremediation. The research on minimal genomes is carried on identifying the smallest number of genomes needed for engineering minimal cell factories and research on chemical synthetic biology is focused on artificial proteins and expanded genetic code. The research on protocells is more in combination with the research on molecular-scale motors. The research on DNA synthesis and its commercialisation are also reviewed. As for the perspective on potential future Chinese R&D activities, it will be discussed based on the research capacity and governmental policy. PMID:21729747

Medical student service learning program teaches secondary students about career opportunities in health and medical fields.

PubMed

Karpa, Kelly; Vakharia, Kavita; Caruso, Catherine A; Vechery, Colin; Sipple, Lanette; Wang, Adrian

2015-12-01

Engagement of academic medical centers in community outreach provides the public with a better understanding of basic terms and concepts used in biomedical sciences and increases awareness of important health information. Medical students at one academic medical center initiated an educational outreach program, called PULSE, that targets secondary students to foster their interest in healthcare and medicine. High school student participants are engaged in a semester-long course that relies on interactive lectures, problem-based learning sessions, mentoring relationships with medical students, and opportunities for shadowing healthcare providers. To date, the curriculum has been offered for 7 consecutive years. To determine the impact that participation in the curriculum has had on college/career choices and to identify areas for improvement, an electronic questionnaire was sent to former participants. Based on a 32% response rate, 81% of former participants indicated that participation in the course influenced their decision to pursue a medical/science-related career. More than half (67%) of respondents indicated intent to pursue a MD/PhD or other postgraduate degree. Based on responses obtained, additional opportunities to incorporate laboratory-based research and simulation sessions should be explored. In addition, a more formalized mentoring component has been added to the course to enhance communication between medical students and mentees. Health/medicine-related educational outreach programs targeting high school students may serve as a pipeline to introduce or reinforce career opportunities in healthcare and related sciences. Copyright © 2015 The American Physiological Society.

Basic science right, not basic science lite: medical education at a crossroad.

PubMed

Fincher, Ruth-Marie E; Wallach, Paul M; Richardson, W Scott

2009-11-01

This perspective is a counterpoint to Dr. Brass' article, Basic biomedical sciences and the future of medical education: implications for internal medicine. The authors review development of the US medical education system as an introduction to a discussion of Dr. Brass' perspectives. The authors agree that sound scientific foundations and skill in critical thinking are important and that effective educational strategies to improve foundational science education should be implemented. Unfortunately, many students do not perceive the relevance of basic science education to clinical practice.The authors cite areas of disagreement. They believe it is unlikely that the importance of basic sciences will be diminished by contemporary directions in medical education and planned modifications of USMLE. Graduates' diminished interest in internal medicine is unlikely from changes in basic science education.Thoughtful changes in education provide the opportunity to improve understanding of fundamental sciences, the process of scientific inquiry, and translation of that knowledge to clinical practice.

Is the use of sentient animals in basic research justifiable?

PubMed Central

2010-01-01

Animals can be used in many ways in science and scientific research. Given that society values sentient animals and that basic research is not goal oriented, the question is raised: "Is the use of sentient animals in basic research justifiable?" We explore this in the context of funding issues, outcomes from basic research, and the position of society as a whole on using sentient animals in research that is not goal oriented. We conclude that the use of sentient animals in basic research cannot be justified in light of society's priorities. PMID:20825676

Is the use of sentient animals in basic research justifiable?

PubMed

Greek, Ray; Greek, Jean

2010-09-08

Animals can be used in many ways in science and scientific research. Given that society values sentient animals and that basic research is not goal oriented, the question is raised: "Is the use of sentient animals in basic research justifiable?" We explore this in the context of funding issues, outcomes from basic research, and the position of society as a whole on using sentient animals in research that is not goal oriented. We conclude that the use of sentient animals in basic research cannot be justified in light of society's priorities.

Contextualizing the relevance of basic sciences: small-group simulation with debrief for first- and second-year medical students in an integrated curriculum.

PubMed

Ginzburg, Samara B; Brenner, Judith; Cassara, Michael; Kwiatkowski, Thomas; Willey, Joanne M

2017-01-01

There has been a call for increased integration of basic and clinical sciences during preclinical years of undergraduate medical education. Despite the recognition that clinical simulation is an effective pedagogical tool, little has been reported on its use to demonstrate the relevance of basic science principles to the practice of clinical medicine. We hypothesized that simulation with an integrated science and clinical debrief used with early learners would illustrate the importance of basic science principles in clinical diagnosis and management of patients. Small groups of first- and second-year medical students were engaged in a high-fidelity simulation followed by a comprehensive debrief facilitated by a basic scientist and clinician. Surveys including anchored and open-ended questions were distributed at the conclusion of each experience. The majority of the students agreed that simulation followed by an integrated debrief illustrated the clinical relevance of basic sciences (mean ± standard deviation: 93.8% ± 2.9% of first-year medical students; 96.7% ± 3.5% of second-year medical students) and its importance in patient care (92.8% of first-year medical students; 90.4% of second-year medical students). In a thematic analysis of open-ended responses, students felt that these experiences provided opportunities for direct application of scientific knowledge to diagnosis and treatment, improving student knowledge, simulating real-world experience, and developing clinical reasoning, all of which specifically helped them understand the clinical relevance of basic sciences. Small-group simulation followed by a debrief that integrates basic and clinical sciences is an effective means of demonstrating the relationship between scientific fundamentals and patient care for early learners. As more medical schools embrace integrated curricula and seek opportunities for integration, our model is a novel approach that can be utilized.

Fundulus as the Premier Teleost Model in Environmental Biology: Opportunities for New Insights Using Genomics

PubMed Central

Burnett, Karen G.; Bain, Lisa J.; Baldwin, William S.; Callard, Gloria V.; Cohen, Sarah; Di Giulio, Richard T.; Evans, David H.; Gómez-Chiarri, Marta; Hahn, Mark E.; Hoover, Cindi A.; Karchner, Sibel I.; Katoh, Fumi; MacLatchy, Deborah L.; Marshall, William S.; Meyer, Joel N.; Nacci, Diane E.; Oleksiak, Marjorie F.; Rees, Bernard B.; Singer, Thomas D.; Stegeman, John J.; Towle, David W.; Van Veld, Peter A.; Vogelbein, Wolfgang K.; Whitehead, Andrew; Winn, Richard N.; Crawford, Douglas L.

2007-01-01

A strong foundation of basic and applied research documents that the estuarine fish Fundulus heteroclitus and related species are unique laboratory and field models for understanding how individuals and populations interact with their environment. In this paper we summarize an extensive body of work examining the adaptive responses of Fundulus species to environmental conditions, and describe how this research has contributed importantly to our understanding of physiology, gene regulation, toxicology, and ecological and evolutionary genetics of teleosts and other vertebrates. These explorations have reached a critical juncture at which advancement is hindered by the lack of genomic resources for these species. We suggest that a more complete genomics toolbox for F. heteroclitus and related species will permit researchers to exploit the power of this model organism to rapidly advance our understanding of fundamental biological and pathological mechanisms among vertebrates, as well as ecological strategies and evolutionary processes common to all living organisms. PMID:18071578

A Career at a Small Liberal Arts College.

PubMed

Punt, Jennifer

2017-10-03

A career as a tenure-track professor at a liberal arts college provides the opportunity to combine serious interests in teaching with research. The basic goals of the liberal arts institution are to educate the student broadly while encouraging mastery of a particular area of interest. Preparing for such a career requires not only a commitment to teaching but also a productive PhD and postdoctoral experience, regardless of the expectations for active research within the job. The application and interview processes require one to be informed, flexible, energetic, and clear-in writing and in speaking. Establishing an invigorating teaching and research program will allow you to balance realism and ambition as you find a way to bring the best science to the undergraduate setting. The exposure to students whose thinking is often more unfettered and creative, and to colleagues whose scholarships span many disciplines, makes a position at a liberal arts college one of the most intellectually stimulating careers available to a scientist. Copyright © 2017 Cold Spring Harbor Laboratory Press; all rights reserved.

A Guide for the Design of Pre-clinical Studies on Sex Differences in Metabolism.

PubMed

Mauvais-Jarvis, Franck; Arnold, Arthur P; Reue, Karen

2017-06-06

In animal models, the physiological systems involved in metabolic homeostasis exhibit a sex difference. Investigators often use male rodents because they show metabolic disease better than females. Thus, females are not used precisely because of an acknowledged sex difference that represents an opportunity to understand novel factors reducing metabolic disease more in one sex than the other. The National Institutes of Health (NIH) mandate to consider sex as a biological variable in preclinical research places new demands on investigators and peer reviewers who often lack expertise in model systems and experimental paradigms used in the study of sex differences. This Perspective discusses experimental design and interpretation in studies addressing the mechanisms of sex differences in metabolic homeostasis and disease, using animal models and cells. We also highlight current limitations in research tools and attitudes that threaten to delay progress in studies of sex differences in basic animal research. Copyright © 2017 Elsevier Inc. All rights reserved.

Building up careers in translational neuroscience and mental health research: Education and training in the Centre for Biomedical Research in Mental Health.

PubMed

Rapado-Castro, Marta; Pazos, Ángel; Fañanás, Lourdes; Bernardo, Miquel; Ayuso-Mateos, Jose Luis; Leza, Juan Carlos; Berrocoso, Esther; de Arriba, Jose; Roldán, Laura; Sanjuán, Julio; Pérez, Victor; Haro, Josep M; Palomo, Tomás; Valdizan, Elsa M; Micó, Juan Antonio; Sánchez, Manuel; Arango, Celso

2015-01-01

The number of large collaborative research networks in mental health is increasing. Training programs are an essential part of them. We critically review the specific implementation of a research training program in a translational Centre for Biomedical Research in Mental Health in order to inform the strategic integration of basic research into clinical practice to have a positive impact in the mental health system and society. Description of training activities, specific educational programs developed by the research network, and challenges on its implementation are examined. The Centre for Biomedical Research in Mental Health has focused on training through different activities which have led to the development of an interuniversity master's degree postgraduate program in mental health research, certified by the National Spanish Agency for Quality Evaluation and Accreditation. Consolidation of training programs within the Centre for Biomedical Research in Mental Health has considerably advanced the training of researchers to meet competency standards on research. The master's degree constitutes a unique opportunity to accomplish neuroscience and mental health research career-building within the official framework of university programs in Spain. Copyright © 2014 SEP y SEPB. Published by Elsevier España. All rights reserved.

Learner-Adaptive Educational Technology for Simulation in Healthcare: Foundations and Opportunities.

PubMed

Lineberry, Matthew; Dev, Parvati; Lane, H Chad; Talbot, Thomas B

2018-06-01

Despite evidence that learners vary greatly in their learning needs, practical constraints tend to favor ''one-size-fits-all'' educational approaches, in simulation-based education as elsewhere. Adaptive educational technologies - devices and/or software applications that capture and analyze relevant data about learners to select and present individually tailored learning stimuli - are a promising aid in learners' and educators' efforts to provide learning experiences that meet individual needs. In this article, we summarize and build upon the 2017 Society for Simulation in Healthcare Research Summit panel discussion on adaptive learning. First, we consider the role of adaptivity in learning broadly. We then outline the basic functions that adaptive learning technologies must implement and the unique affordances and challenges of technology-based approaches for those functions, sharing an illustrative example from healthcare simulation. Finally, we consider future directions for accelerating research, development, and deployment of effective adaptive educational technology and techniques in healthcare simulation.

The tuskegee experiment: an introduction in ethics for pre-healthcare professional students.

PubMed

Miranda, Daniel; Sanchez, David Jesse

2014-12-01

Over the past years, professional students have had extensive exposure to clinical cases during basic science classes. With this in mind, we have taken this clinical case exposure moment to be an opportune time to introduce the ethics of working with patients during biomedical research. Our goal is to present a straightforward assignment that allows for active student research into the facts of the Tuskegee Experiment of the 1900s. The assignment provides the necessary background to allow for a student-centered discussion on the ethical issues of the events and ramifications of what happened. Thus, in educating a class on the event's happenings, one concomitantly creates a platform for meaningful discussion on the principles and ethics of patient care. We have found that an ethics-infused event such as the Tuskegee Experiment is an excellent way to introduce students to these topics.

Challenges to Superfund Community Nutrition Programs in Kentucky

PubMed Central

Gaetke, Lisa; Gaetke, Kara; Bowen, Christa

2008-01-01

Since 2000, the University of Kentucky's (UK's) Superfund Basic Research Program (SBRP) Community Outreach Core has provided support and guidance through Superfund Community Action through Nutrition (SCAN) programs, which meet the needs of individuals and communities affected by environmental contaminants. It has been shown that nutrition may modulate the toxicity of Superfund chemicals. SCAN programs integrate nutrition education, nutrition science research, and health communication to increase understanding of health risks associated with residing near Superfund sites. Two critical tasks must be accomplished. SCAN personnel must identify and recruit affected community members, and then, offer meaningful programs. Certain quantitative outcome measures and legal issues presented both challenges and opportunities. Community members preferred qualitative evaluation discussions, which showed increased knowledge and improved attitudes following SCAN programs. SCAN, in full partnership with affected communities, translates safe, effective nutrition information to reduce health risks associated with exposure to Superfund pollutants. PMID:18443657

Challenges to superfund community nutrition programs in kentucky.

PubMed

Gaetke, Lisa; Gaetke, Kara; Bowen, Christa

2008-03-01

Since 2000, the University of Kentucky's (UK's) Superfund Basic Research Program (SBRP) Community Outreach Core has provided support and guidance through Superfund Community Action through Nutrition (SCAN) programs, which meet the needs of individuals and communities affected by environmental contaminants. It has been shown that nutrition may modulate the toxicity of Superfund chemicals. SCAN programs integrate nutrition education, nutrition science research, and health communication to increase understanding of health risks associated with residing near Superfund sites. Two critical tasks must be accomplished. SCAN personnel must identify and recruit affected community members, and then, offer meaningful programs. Certain quantitative outcome measures and legal issues presented both challenges and opportunities. Community members preferred qualitative evaluation discussions, which showed increased knowledge and improved attitudes following SCAN programs. SCAN, in full partnership with affected communities, translates safe, effective nutrition information to reduce health risks associated with exposure to Superfund pollutants.

Energy Security: From Deal Killers to Game Changers

NASA Astrophysics Data System (ADS)

Orbach, Raymond L.

2010-03-01

Five ``deal killers'' for achieving energy security will be addressed: 1) Global warming and CO2 emissions from fossil fuel combustion, 2) Intermittent energy sources (wind, solar) and the presence and stability of the grid, 3) Penetration of plant defenses to produce transportation fuels from biomass, 4) Mimicking nature: artificial photosynthesis for solar energy-to-fuels, and 5) Spent fuel from nuclear power reactors. Basic research can lead to ``game changers'' for these five fields: 1) Carbon capture and storage through enhanced oil and gas recovery, 2) Electrical energy storage for base-load electricity through batteries and supercapacitors, 3) Genetic modification of the plant cell wall, and catalytic methods for conversion of plant sugars to fuels, 4) Separation of solar-induced electrons from holes, and catalysis to produce fuels, and 5) Closing the nuclear fuel cycle. The present state for each of these game changers will be summarized, and future research opportunities discussed.

The Tuskegee Experiment: An Introduction in Ethics for Pre-Healthcare Professional Students†

PubMed Central

Miranda, Daniel; Sanchez, David Jesse

2014-01-01

Over the past years, professional students have had extensive exposure to clinical cases during basic science classes. With this in mind, we have taken this clinical case exposure moment to be an opportune time to introduce the ethics of working with patients during biomedical research. Our goal is to present a straightforward assignment that allows for active student research into the facts of the Tuskegee Experiment of the 1900s. The assignment provides the necessary background to allow for a student-centered discussion on the ethical issues of the events and ramifications of what happened. Thus, in educating a class on the event’s happenings, one concomitantly creates a platform for meaningful discussion on the principles and ethics of patient care. We have found that an ethics-infused event such as the Tuskegee Experiment is an excellent way to introduce students to these topics. PMID:25574286

Mitochondrial Function in Sepsis

PubMed Central

Arulkumaran, Nishkantha; Deutschman, Clifford S.; Pinsky, Michael R.; Zuckerbraun, Brian; Schumacker, Paul T.; Gomez, Hernando; Gomez, Alonso; Murray, Patrick; Kellum, John A.

2015-01-01

Mitochondria are an essential part of the cellular infrastructure, being the primary site for high energy adenosine triphosphate (ATP) production through oxidative phosphorylation. Clearly, in severe systemic inflammatory states, like sepsis, cellular metabolism is usually altered and end organ dysfunction not only common but predictive of long term morbidity and mortality. Clearly, interest is mitochondrial function both as a target for intracellular injury and response to extrinsic stress have been a major focus of basic science and clinical research into the pathophysiology of acute illness. However, mitochondria have multiple metabolic and signaling functions that may be central in both the expression of sepsis and its ultimate outcome. In this review, the authors address five primary questions centered on the role of mitochondria in sepsis. This review should be used as both a summary source in placing mitochondrial physiology within the context of acute illness and as a focal point for addressing new research into diagnostic and treatment opportunities these insights provide. PMID:26871665

MITOCHONDRIAL FUNCTION IN SEPSIS.

PubMed

Arulkumaran, Nishkantha; Deutschman, Clifford S; Pinsky, Michael R; Zuckerbraun, Brian; Schumacker, Paul T; Gomez, Hernando; Gomez, Alonso; Murray, Patrick; Kellum, John A

2016-03-01

Mitochondria are an essential part of the cellular infrastructure, being the primary site for high-energy adenosine triphosphate production through oxidative phosphorylation. Clearly, in severe systemic inflammatory states, like sepsis, cellular metabolism is usually altered, and end organ dysfunction is not only common, but also predictive of long-term morbidity and mortality. Clearly, interest is mitochondrial function both as a target for intracellular injury and response to extrinsic stress have been a major focus of basic science and clinical research into the pathophysiology of acute illness. However, mitochondria have multiple metabolic and signaling functions that may be central in both the expression of sepsis and its ultimate outcome. In this review, the authors address five primary questions centered on the role of mitochondria in sepsis. This review should be used both as a summary source in placing mitochondrial physiology within the context of acute illness and as a focal point for addressing new research into diagnostic and treatment opportunities these insights provide.

Reflections on biomedical informatics: from cybernetics to genomic medicine and nanomedicine.

PubMed

Maojo, Victor; Kulikowski, Casimir A

2006-01-01

Expanding on our previous analysis of Biomedical Informatics (BMI), the present perspective ranges from cybernetics to nanomedicine, based on its scientific, historical, philosophical, theoretical, experimental, and technological aspects as they affect systems developments, simulation and modelling, education, and the impact on healthcare. We then suggest that BMI is still searching for strong basic scientific principles around which it can crystallize. As -omic biological knowledge increasingly impacts the future of medicine, ubiquitous computing and informatics become even more essential, not only for the technological infrastructure, but as a part of the scientific enterprise itself. The Virtual Physiological Human and investigations into nanomedicine will surely produce yet more unpredictable opportunities, leading to significant changes in biomedical research and practice. As a discipline involved in making such advances possible, BMI is likely to need to re-define itself and extend its research horizons to meet the new challenges.

Optimal design in pediatric pharmacokinetic and pharmacodynamic clinical studies.

PubMed

Roberts, Jessica K; Stockmann, Chris; Balch, Alfred; Yu, Tian; Ward, Robert M; Spigarelli, Michael G; Sherwin, Catherine M T

2015-03-01

It is not trivial to conduct clinical trials with pediatric participants. Ethical, logistical, and financial considerations add to the complexity of pediatric studies. Optimal design theory allows investigators the opportunity to apply mathematical optimization algorithms to define how to structure their data collection to answer focused research questions. These techniques can be used to determine an optimal sample size, optimal sample times, and the number of samples required for pharmacokinetic and pharmacodynamic studies. The aim of this review is to demonstrate how to determine optimal sample size, optimal sample times, and the number of samples required from each patient by presenting specific examples using optimal design tools. Additionally, this review aims to discuss the relative usefulness of sparse vs rich data. This review is intended to educate the clinician, as well as the basic research scientist, whom plan on conducting a pharmacokinetic/pharmacodynamic clinical trial in pediatric patients. © 2015 John Wiley & Sons Ltd.

Watershed Landscape Ecology: Interdisciplinary and Field-based Learning in the Northeast Creek Watershed, Mount Desert Island, Maine

NASA Astrophysics Data System (ADS)

Hall, S. R.; Anderson, J.; Rajakaruna, N.; Cass, D.

2014-12-01

At the College of the Atlantic, Bar Harbor, Maine, undergraduate students have the opportunity to design their own curriculum within a major of "Human Ecology." To enable students to have early research experiences, we developed a field-based interdisciplinary program for students to learn and practice field methods in a variety of disciplines, Earth Science, Botany, Chemistry, and Wildlife Biology at three specific field sites within a single watershed on Mt. Desert Island. As the Northeast Creek watershed was the site of previous water quality studies, this program of courses enabled continued monitoring of portions of the watershed. The program includes 4 new courses: Critical Zone 1, Critical Zone 2, Wildlife Biology, and Botany. In Critical Zone 1 students are introduced to general topics in Earth Science and learn to use ArcGIS to make basic maps. In Critical Zone 2, Wildlife Biology, and Botany, students are in the field every week using classic field tools and methods. All three of these courses use the same three general field areas: two with working farms at the middle and lower portion of the watershed and one uninhabited forested property in the higher relief headwaters of the watershed. Students collect daily surface water chemistry data at five stream sites within the watershed, complete basic geologic bedrock and geomorphic mapping, conduct wildlife surveys, botanical surveys, and monitor weather patterns at each of the main sites. Beyond the class data collected and synthesized, students also complete group independent study projects at focused field sites, some of which have turned into much larger research projects. This program is an opportunity for students and faculty with varied interests and expertise to work together to study a specific field locality over multiple years. We see this model as enhancing a number of positive education components: field-based learning, teamwork, problem solving, interdisciplinary discussion, multiple faculty interaction, student mentoring, and original research. In the future we see the possibility of welcoming even more interdisciplinary work including rigorous studies spanning the arts and humanities.

Citizen Science: Broadening Access and Engagement Through Community Partnerships, Aerospace Education and Water Quality Research

NASA Astrophysics Data System (ADS)

Johnson, M. A.

2016-12-01

We applied a new approach to the design and development of citizen science learning opportunities to enhance outreach to diverse student populations, while advancing water quality research and aerospace education. This collaborative approach to informal science, technology, engineering, and math (STEM) and aerospace education required innovative partnerships between private general aviation pilots, researchers, teachers, and students. This research explored the development of active partnerships required to facilitate community engaged science, with an emphasis on increased participation of women and girls and people of color, while creating new exploratory pathways for broadening access to and engagement in STEM learning experiences. We developed an outreach program through collaborative planning with local schools to create new STEM learning experiences based upon basic aerospace education concepts and an existing water quality research project designed to track harmful algal blooms (HAB) that can produce toxins called cyanobacteria, also known as blue-green algae, which can impact drinking, fishing, and recreational waters. General aviation pilots functioning as citizen scientists obtained high-resolution aerial images while flying over potentially impacted waters. Aerial data was made available to teachers and students, as well as researchers participating in the existing water quality program lead by NASA Glenn Research Center. Teachers used the images and results to educate in climate change and the dangers of HAB. Students were able to compare aerial data with their own observations, and also gained experience in aeronautical science through field trips to local airports, hands-on experience with private research aircraft, specialized equipment used for data collection, and advanced ground instruction from research pilots. As a result of reaching out to local educators serving diverse student populations and facilitating collaborative planning, we successfully created new educational opportunities with active partnerships between formal educational institutions and informal citizen science research programs, which broadened access to and engagement in aerospace education and STEM learning experiences in our local community.

Overcoming research barriers in Chagas disease-designing effective implementation science.

PubMed

Henao-Martínez, Andrés F; Colborn, Kathryn; Parra-Henao, Gabriel

2017-01-01

Chagas disease is a complex tropical parasitic infection. It affects a significant portion of the population in Latin America, especially in areas of poverty and poor access to health care. It also affects immigrants in high-income countries who lack access to health care due to their legal status. Millions of people are at risk of contracting the disease, and approximately 30 % of chronically infected patients will develop cardiomyopathy. The cost of caring for patients that have been infected is substantial. Basic science research has introduced new concepts and knowledge for the parasite and vector biology as well as better understanding of the pathophysiology of the disease. These research findings nevertheless require effective and timely translation into clinical practice. Likewise, the design of new research projects should account for the multiple system-based barriers. Implementation science facilitates the applicability of research findings and identifies barriers to its execution. Creation of implementation science measures to reach and sustain research programs with greater potential to impact Chagas disease are lacking. This point of view proposes opportunities for implementation science in Chagas disease and strategies for researching effective interventions for preventing and treating the disease.

Future Directions in Idiopathic Pulmonary Fibrosis Research. An NHLBI Workshop Report

PubMed Central

Blackwell, Timothy S.; Tager, Andrew M.; Borok, Zea; Moore, Bethany B.; Schwartz, David A.; Anstrom, Kevin J.; Bar-Joseph, Ziv; Bitterman, Peter; Blackburn, Michael R.; Bradford, William; Brown, Kevin K.; Chapman, Harold A.; Collard, Harold R.; Cosgrove, Gregory P.; Deterding, Robin; Doyle, Ramona; Flaherty, Kevin R.; Garcia, Christine Kim; Hagood, James S.; Henke, Craig A.; Herzog, Erica; Hogaboam, Cory M.; Horowitz, Jeffrey C.; King, Talmadge E.; Loyd, James E.; Lawson, William E.; Marsh, Clay B.; Noble, Paul W.; Noth, Imre; Sheppard, Dean; Olsson, Julie; Ortiz, Luis A.; O’Riordan, Thomas G.; Oury, Tim D.; Raghu, Ganesh; Roman, Jesse; Sime, Patricia J.; Sisson, Thomas H.; Tschumperlin, Daniel; Violette, Shelia M.; Weaver, Timothy E.; Wells, Rebecca G.; White, Eric S.; Kaminski, Naftali; Martinez, Fernando J.; Wynn, Thomas A.; Thannickal, Victor J.

2014-01-01

The median survival of patients with idiopathic pulmonary fibrosis (IPF) continues to be approximately 3 years from the time of diagnosis, underscoring the lack of effective medical therapies for this disease. In the United States alone, approximately 40,000 patients die of this disease annually. In November 2012, the NHLBI held a workshop aimed at coordinating research efforts and accelerating the development of IPF therapies. Basic, translational, and clinical researchers gathered with representatives from the NHLBI, patient advocacy groups, pharmaceutical companies, and the U.S. Food and Drug Administration to review the current state of IPF research and identify priority areas, opportunities for collaborations, and directions for future research. The workshop was organized into groups that were tasked with assessing and making recommendations to promote progress in one of the following six critical areas of research: (1) biology of alveolar epithelial injury and aberrant repair; (2) role of extracellular matrix; (3) preclinical modeling; (4) role of inflammation and immunity; (5) genetic, epigenetic, and environmental determinants; (6) translation of discoveries into diagnostics and therapeutics. The workshop recommendations provide a basis for directing future research and strategic planning by scientific, professional, and patient communities and the NHLBI. PMID:24160862

Research and development needs in the Department of Energy. Interim report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1980-09-05

In April 1980, the Deputy Secretary requested that the Board participate in the Department's review of the technology base component of DOE's R and D programs and that the Board address the following broad concerns: (1) The adequacy of the research underpinning for technology development programs; (2) Possible gaps or duplications of effort; (3) The balance among research performers (universities, laboratories, industry); (4) Significant R and D opportunities that DOE's programs may be missing. The Board offered the following recommendations to the Secretary: (1) Place greater research emphasis on environmental and health issues to ensure the success of the nationalmore » synfuels program. (2) Provide more research in energy use and productivity projects. (3) Increase the level of effort in basic research. (4) Place higher priority for high-level radioactive waste disposal R and D. (5) Evaluate the various energy technology options on a common comparison basis to clearly identify the costs, benefits and risks of each option. (6) Develop more effective DOE procurement practices. Additional recommendations were directed to the Under Secretary and Assistant Secretaries of Energy reviewing specific issues in conservation, fossil, nuclear and solar energy, resource applications, environment, and energy research.« less

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.

PubMed

Blackwell, Timothy S; Tager, Andrew M; Borok, Zea; Moore, Bethany B; Schwartz, David A; Anstrom, Kevin J; Bar-Joseph, Ziv; Bitterman, Peter; Blackburn, Michael R; Bradford, William; Brown, Kevin K; Chapman, Harold A; Collard, Harold R; Cosgrove, Gregory P; Deterding, Robin; Doyle, Ramona; Flaherty, Kevin R; Garcia, Christine Kim; Hagood, James S; Henke, Craig A; Herzog, Erica; Hogaboam, Cory M; Horowitz, Jeffrey C; King, Talmadge E; Loyd, James E; Lawson, William E; Marsh, Clay B; Noble, Paul W; Noth, Imre; Sheppard, Dean; Olsson, Julie; Ortiz, Luis A; O'Riordan, Thomas G; Oury, Tim D; Raghu, Ganesh; Roman, Jesse; Sime, Patricia J; Sisson, Thomas H; Tschumperlin, Daniel; Violette, Shelia M; Weaver, Timothy E; Wells, Rebecca G; White, Eric S; Kaminski, Naftali; Martinez, Fernando J; Wynn, Thomas A; Thannickal, Victor J; Eu, Jerry P

2014-01-15

The median survival of patients with idiopathic pulmonary fibrosis (IPF) continues to be approximately 3 years from the time of diagnosis, underscoring the lack of effective medical therapies for this disease. In the United States alone, approximately 40,000 patients die of this disease annually. In November 2012, the NHLBI held a workshop aimed at coordinating research efforts and accelerating the development of IPF therapies. Basic, translational, and clinical researchers gathered with representatives from the NHLBI, patient advocacy groups, pharmaceutical companies, and the U.S. Food and Drug Administration to review the current state of IPF research and identify priority areas, opportunities for collaborations, and directions for future research. The workshop was organized into groups that were tasked with assessing and making recommendations to promote progress in one of the following six critical areas of research: (1) biology of alveolar epithelial injury and aberrant repair; (2) role of extracellular matrix; (3) preclinical modeling; (4) role of inflammation and immunity; (5) genetic, epigenetic, and environmental determinants; (6) translation of discoveries into diagnostics and therapeutics. The workshop recommendations provide a basis for directing future research and strategic planning by scientific, professional, and patient communities and the NHLBI.

The NASA Materials Science Research Program: It's New Strategic Goals and Opportunities

NASA Technical Reports Server (NTRS)

Schlagheck, Ronald A.; Stagg, Elizabeth

2004-01-01

In the past year, the NASA s Office of Biological and Physical Research (OBPR) has formulated a long term plan to perform strategical and fundamental research bringing together physics, chemistry, biology, and engineering to solve problems needed for current and future agency mission goals. Materials Science is one of basic disciplines within the Enterprise s Division of Physical Sciences Research. The Materials Science Program participates to utilize effective use of International Space Station (ISS) and various world class ground laboratory facilities to solve new scientific and technology questions and transfer these results for public and agency benefits. The program has recently targeted new investigative research in strategic areas necessary to expand NASA knowledge base for exploration of the universe and some of these experiments will need access to the microgravity of space. The program is implementing a wide variety of traditional ground and flight based research related types of fundamental science related to materials crystallization, fundamental processing, and properties characterization in order to obtain basic understanding of various phenomena effects and relationships to the structures, processing, and properties of materials. , In addition new initiatives in radiation protection, materials for propulsion and In-space fabrication and repair focus on research helping the agency solve problems needed for future transportation into the solar system. A summary of the types and sources for this research is presented including those experiments planned for a low gravity environment. Areas to help expand the science basis for NASA future missions are described. An overview of the program is given including the scope of the current and future NASA Research Announcements with emphasis on new materials science initiatives. A description of the planned flight experiments to be conducted on the International Space Station program along with the planned facility class Materials Science Research Rack (MSRR) and Microgravity Glovebox (MSG) type investigations. Some initial results from the first three materials experiments are given.

Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society.

PubMed

Akbani, Rehan; Becker, Karl-Friedrich; Carragher, Neil; Goldstein, Ted; de Koning, Leanne; Korf, Ulrike; Liotta, Lance; Mills, Gordon B; Nishizuka, Satoshi S; Pawlak, Michael; Petricoin, Emanuel F; Pollard, Harvey B; Serrels, Bryan; Zhu, Jingchun

2014-07-01

Reverse phase protein array (RPPA) technology introduced a miniaturized "antigen-down" or "dot-blot" immunoassay suitable for quantifying the relative, semi-quantitative or quantitative (if a well-accepted reference standard exists) abundance of total protein levels and post-translational modifications across a variety of biological samples including cultured cells, tissues, and body fluids. The recent evolution of RPPA combined with more sophisticated sample handling, optical detection, quality control, and better quality affinity reagents provides exquisite sensitivity and high sample throughput at a reasonable cost per sample. This facilitates large-scale multiplex analysis of multiple post-translational markers across samples from in vitro, preclinical, or clinical samples. The technical power of RPPA is stimulating the application and widespread adoption of RPPA methods within academic, clinical, and industrial research laboratories. Advances in RPPA technology now offer scientists the opportunity to quantify protein analytes with high precision, sensitivity, throughput, and robustness. As a result, adopters of RPPA technology have recognized critical success factors for useful and maximum exploitation of RPPA technologies, including the following: preservation and optimization of pre-analytical sample quality, application of validated high-affinity and specific antibody (or other protein affinity) detection reagents, dedicated informatics solutions to ensure accurate and robust quantification of protein analytes, and quality-assured procedures and data analysis workflows compatible with application within regulated clinical environments. In 2011, 2012, and 2013, the first three Global RPPA workshops were held in the United States, Europe, and Japan, respectively. These workshops provided an opportunity for RPPA laboratories, vendors, and users to share and discuss results, the latest technology platforms, best practices, and future challenges and opportunities. The outcomes of the workshops included a number of key opportunities to advance the RPPA field and provide added benefit to existing and future participants in the RPPA research community. The purpose of this report is to share and disseminate, as a community, current knowledge and future directions of the RPPA technology. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

Implementing Cancer Prevention into Clinical Practice

PubMed Central

Sabado, Parichart; Bernstein, Leslie; Bispeck, M. Katherine; Hawk, Ernest; Krawiec, Virginia; O'Donnell, Joseph F.; Silverman, Sol

2014-01-01

Cancer prevention has been associated with decreased rates of cancer incidence and increased survival. Cancer prevention, however, can have a greater impact if barriers to implementing cancer prevention into practice are removed and opportunities are both fostered and seized. The purpose of this article is to identify barriers and opportunities to cancer prevention in clinical practice and provide recommendations for the future. A multidisciplinary team participated in “The Future Directions Cancer Prevention and Control: Workforce Implications for Training, Practice and Policy” workshop on October 17-18, 2009 at The University of Texas MD Anderson Cancer Center in Houston, TX. During the meeting, the team discussed barriers and opportunities for the implementation of cancer prevention into clinical practice. Further data were collected from peer-reviewed journals and published government and cancer agencies reports. Several issues were identified: 1) The funding allocated to basic cancer prevention research and application is not optimal and less than that for cancer treatment; 2) Participation in cancer prevention behaviors and screening practices are lower than desired, especially among the uninsured; 3) A shortage in healthcare professionals is a major challenge in meeting the future needs of cancer prevention; 4) Demands on medical schools to balance increased enrollment, incorporate cancer prevention in an already crowded curriculum, and develop faculty are daunting; and 5) Healthcare reforms in 2010 provide both opportunities and additional challenges for cancer prevention. Based on the current state of cancer prevention, we formed six recommendations: 1) Additional funding for cancer prevention research with a focus on implementation into practice; 2) Improved tracking of cancer prevention research funding and the outcomes associated with it; 3) Continued monitoring of cancer prevention services participation with emphasis on closing the gap in health disparities; 4) Financial and technical assistance to healthcare professional schools for incorporating cancer prevention into curricula; 5) Assessment of the current state of technology in cancer prevention care; and 6) The use of effective multidisciplinary teams in cancer prevention care. Improved delivery of cancer prevention services can have a tremendous impact on cancer incidence and survival rates. PMID:22367592

Evaluation of a mid-career investigator career development award: Assessing the ability of OppNet K18 awardees to obtain NIH follow-on research funding.

PubMed

Pomeroy-Carter, Cassidy A; Williams, Sharon R; Han, Xueying; Elwood, William N; Zuckerman, Brian L

2018-01-01

The National Institutes of Health (NIH) K18 award mechanism provides funded opportunities for established investigators to gain knowledge in fields outside of their primary disciplines, but outcomes associated with these awards have not been evaluated to date. NIH's Basic Behavioral and Social Sciences Opportunity Network (OppNet) is one of the few initiatives that has used this award mechanism. We explored how the unique features of K18 awards affect the ability of recipients to obtain follow-on NIH research funding. We compared outcomes (ability to obtain follow-on funding and interval between receipt of the primary award and receipt of the first follow-on award) associated with OppNet K18 awards to findings from evaluations of other NIH career development (K) awards, which usually target early-career investigators. We hypothesized that K18 award recipients might be (1) more successful than are other K award recipients in obtaining follow-on NIH research funding due to their career experience or (2) less successful due to the competing demands of other projects. By analyzing follow-on NIH research awards and interview data, we found that OppNet K18 award recipients were at least as successful as were other K award recipients in obtaining follow-on funding and may have been more successful by certain measures. K18 awards produce their outcomes with a lower investment per investigator than do other K awards, suggesting continued or enhanced use of the mechanism.