Questions and Answers about Treating Arterial Stenosis and Preventing Stroke

MedlinePlus

... Strategy Current Research Research Funded by NINDS Basic Neuroscience Clinical Research Translational Research Research at NINDS Focus ... Diversity Resources Jobs at NINDS Director, Division of Neuroscience Director, NIH BRAIN Initiative® Health Scientist Administrator Channels ...

Bridging Policy Implementation Gaps in Nigerian Education System: A Case Study of Universal Basic Education Programme in Cross River State, Nigeria

ERIC Educational Resources Information Center

Ogbiji, Joseph Etiongbie; Ogbiji, Sylvanus Achua

2016-01-01

This research focuses on identifying policy gaps in the implementation of Universal Basic Education (UBE) programme in Nigeria, with Cross River State being the study area. The three research questions used for the research center on the extent of the freeness of the UBE, the extent to which the programme has stimulated educational consciousness…

How Asking a Very Basic Research Question Led Us to a Model for at Least Three Diseases | Poster

Cancer.gov

By Howard Young Editor’s note: This article is adapted from Dr. Young’s January 12, 2015, post to the I am Intramural Blog of the Intramural Research Program. When I started this project, it was not my objective to develop a model for any specific disease, nor did I even suspect that the ultimate result would be some insight into autoimmune disease. The basic research question I was asking was why there are sequences in the 3? untranslated region (3?UTR) of the interferon-gamma (IFN-gamma) mRNA that are more highly conserved than in the coding region of the gene.

Electronic Data Interchange in U.S. Navy Contracting Activities

DTIC Science & Technology

1992-12-01

the basic research question, the following subsidiary questions were asked: 1. How is EDI being used in the private sector and within the Department of...eliminated by using EDI transactions. According to a DoD small business EDI Guide , (DLA Partnership, 1991, p.15) in financial management applications, a...and to place orders against basic ordering agreements (BOA). The ASO is currently transmitting the ASC X12 850 [Purchase Order] to approximately 25

Questions and Issues in Basic Writing and Computing (Computers and Controversy).

ERIC Educational Resources Information Center

Gay, Pamela

1991-01-01

Presents findings from 18 reviewed studies with regard to attitude and the quality of writing performance. Discusses pedagogy and the problem of defining basic writers. Suggests research directions that can help move educators toward a new pedagogy. (MG)

Within-Case and Cross-Case Analyses of Questions Posed by Fifth-Grade Students Working in Small Groups to Investigate Pendulum Motion

NASA Astrophysics Data System (ADS)

Tisel, James Michael

The focus of this basic qualitative research is student questions in an unstructured inquiry setting. Case and cross-case analyses were conducted (Miles and Huberman, 1984) of the questions posed by fifth grade students working in laboratory groups of size three to five students as they investigated pendulum motion. To establish the conceptual framework for the study, literature was reviewed in the areas of cognitive theory (constructivism, conceptual change, and other theories), approaches to science, and the importance of student questions in the learning process. A review of group work, related studies of student questions and activities and relevant methods of qualitative research was also undertaken. The current study occupies the relatively unique position of being about the questions students posed to each other (not the teacher) at the outset of and throughout an unstructured inquiry activity with a minimum of teacher initiation or intervention. The focus is on finding out what questions students ask, when they ask them, what categories the questions fall into in relation to possible models of the scientific method, student motivation, and what role the questions play as the students take part in an inquiry activity. Students were video and/or audio-recorded as they did the investigation. They wrote down their questions during one-minute pauses that occurred at roughly eight-minute intervals. The groups were interviewed the next day about their experience. The recordings, question sheets, and interview accounts and recordings were analyzed by the researcher. Accounts of the experience of each group were prepared, and reiterated attempts were made to classify the questions as the main themes and categories emerged. It was found that students posed their key research question (most typically related to pendulum damping effects) midway through the first half of their activity, after having first met some competence and other needs in relation to measurement procedures and basic information. The main research question typically emerged gradually in an implicitly shared form. It was found that Deci and Ryan's self-determination theory (2000) with the core needs of competence, autonomy, and relatedness, served as a useful tool for categorizing and understanding the role of the questions. Basic questions about procedures in relation to gaining competence with measurement were considered by the researcher to be most prevalent. When compared to, for instance, Lawson's hypothetico-predictive model of doing science (2003a) it was noted that puzzling observations were not necessarily made at the outset, and key questions took place much later in the investigative process than what typical scientific models might suggest. Further, more focused research in the areas of self-determination theory in relation to student questions as they engage in inquiry could be of benefit in determining the motivations behind student questions. Educational programs that have, as their goal, authentic student inquiry should take into account that student research questions evolve over time as they meet various needs in the process of initiating their investigations.

Internal Interest or External Performing? A Qualitative Study on Motivation and Learning of 9th Graders in Thailand Basic Education

ERIC Educational Resources Information Center

Loima, Jyrki; Vibulphol, Jutarat

2014-01-01

This qualitative research was the first academic attempt to study and discuss the internal and external motivation in learning of students in basic education schools in Thailand. The study addressed two research questions to analyze similarities and differences in learning motivation or interest and teachers' enhancement or discouragement. 1) What…

malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication

PubMed Central

2017-01-01

Basic science holds enormous power for revealing the biological mechanisms of disease and, in turn, paving the way toward new, effective interventions. Recognizing this power, the 2011 Research Agenda for Malaria Eradication included key priorities in fundamental research that, if attained, could help accelerate progress toward disease elimination and eradication. The Malaria Eradication Research Agenda (malERA) Consultative Panel on Basic Science and Enabling Technologies reviewed the progress, continuing challenges, and major opportunities for future research. The recommendations come from a literature of published and unpublished materials and the deliberations of the malERA Refresh Consultative Panel. These areas span multiple aspects of the Plasmodium life cycle in both the human host and the Anopheles vector and include critical, unanswered questions about parasite transmission, human infection in the liver, asexual-stage biology, and malaria persistence. We believe an integrated approach encompassing human immunology, parasitology, and entomology, and harnessing new and emerging biomedical technologies offers the best path toward addressing these questions and, ultimately, lowering the worldwide burden of malaria. PMID:29190277

Research in the perianesthesia setting: the basics of getting started.

PubMed

Myers, Gina; Kosinski, Michele

2005-02-01

Research can be defined as a process that systematically investigates a situation with the objective of expanding the existing knowledge of a profession. Research asks the question "Does what we do as nurses help or hinder?" The purpose of this article is to provide a brief history of nursing research and to review basic research methods. In addition, examples of potential research projects focused in the perianesthesia practice arena will be explored. Practical steps will be outlined to guide novice nurse researchers in their early endeavors.

Back to the Basics: An Investigation of School- and District-Level Remediation Efforts Associated with Minnesota's Basic Standards for High School Graduation.

ERIC Educational Resources Information Center

Schleisman, Jane L.; Peterson, Kristin A.; Davison, Mark L.

This report describes an investigation of the types of additional instructional opportunities and remediation efforts provided by Minnesota schools and districts for students who do not initially meet basic skill requirements in reading and/or mathematics in eighth grade. Primary research questions included: What additional instructional…

Evaluation of Some Approved Basic Science and Technology Textbooks in Use in Junior Secondary Schools in Nigeria

ERIC Educational Resources Information Center

Nwafor, C. E.; Umoke, C. C.

2016-01-01

This study was designed to evaluate the content adequacy and readability of approved basic science and technology textbooks in use in junior secondary schools in Nigeria. Eight research questions guided the study. The sample of the study consisted of six (6) approved basic science and technology textbooks, 30 Junior Secondary Schools randomly…

Establishing health benefits of bioactive food components: a basic research scientist's perspective

USDA-ARS?s Scientific Manuscript database

Bioactive food components or functional foods have recently received significant attention because of their widely touted positive effects beyond basic nutrition. However, a question continues to lurk: are these 'super foods' backed by sound science or simply an exaggerated portrayal of very small '...

Integrating the dimensions of sex and gender into basic life sciences research: methodologic and ethical issues.

PubMed

Holdcroft, Anita

2007-01-01

The research process -- from study design and selecting a species and its husbandry, through the experiment, analysis, peer review, and publication -- is rarely subject to questions about sex or gender differences in mainstream life sciences research. However, the impact of sex and gender on these processes is important in explaining biological variations and presentation of symptoms and diseases. This review aims to challenge assumptions and to develop opportunities to mainstream sex and gender in basic scientific research. Questions about the mechanisms of sex and gender effects were reviewed in relation to biological, environmental, social, and psychological interactions. Gender variations, in respect to aging, socializing, and reproduction, that are present in human populations but are rarely featured in laboratory research were considered to more effectively translate animal research into clinical health care. Methodologic approaches to address the present lack of a gender dimension in research include actively reducing variations through attention to physical factors, biological rhythms, and experimental design. In addition, through genomic and acute nongenomic activity, hormones may compound effects through multiple small sex differences that occur during the course of an acute pathologic event. Furthermore, the many exogenous sex steroid hormones and their congeners used in medicine (eg, in contraception and cancer therapies) may add to these effects. The studies reviewed provide evidence that sex and gender are determinants of many outcomes in life science research. To embed the gender dimension into basic scientific research, a broad approach -- gender mainstreaming -- is warranted. One example is the use of review boards (eg, animal ethical review boards and journal peer-review boards) in which gender-related standardized questions can be asked about study design and analysis. A more fundamental approach is to question the relevance of present-day laboratory models to design methods to best represent the age-related changes, comorbidity, and variations experienced by each sex in clinical medicine.

Modeling a hierarchical structure of factors influencing exploitation policy for water distribution systems using ISM approach

NASA Astrophysics Data System (ADS)

Jasiulewicz-Kaczmarek, Małgorzata; Wyczółkowski, Ryszard; Gładysiak, Violetta

2017-12-01

Water distribution systems are one of the basic elements of contemporary technical infrastructure of urban and rural areas. It is a complex engineering system composed of transmission networks and auxiliary equipment (e.g. controllers, checkouts etc.), scattered territorially over a large area. From the water distribution system operation point of view, its basic features are: functional variability, resulting from the need to adjust the system to temporary fluctuations in demand for water and territorial dispersion. The main research questions are: What external factors should be taken into account when developing an effective water distribution policy? Does the size and nature of the water distribution system significantly affect the exploitation policy implemented? These questions have shaped the objectives of research and the method of research implementation.

R and D Evaluation Workshop report, U.S. Department of Energy, Office of Energy Research, September 7--8, 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jordan, G.

1995-10-30

The objective of the workshop was to promote discussions between experts and research managers on developing approaches for assessing the impact of DOE`s basic energy research upon the energy mission, applied research, technology transfer, the economy, and society. The purpose of this impact assessment is to demonstrate results and improve ER research programs in this era when basic research is expected to meet changing national economic and social goals. The questions addressed were: (1) By what criteria and metrics does Energy Research measure performance and evaluate its impact on the DOE mission and society while maintaining an environment that fostersmore » basic research? (2) What combination of evaluation methods best applies to assessing the performance and impact of OBES basic research? The focus will be upon the following methods: Case studies, User surveys, Citation analysis, TRACES approach, Return on DOE investment (ROI)/Econometrics, and Expert panels. (3) What combination of methods and specific rules of thumb can be applied to capture impacts along the spectrum from basic research to products and societal impacts?« less

Basic Skills Achievement, 1981-82.

ERIC Educational Resources Information Center

Austin Independent School District, TX. Office of Research and Evaluation.

The Austin Independent School District (AISD) office of Research and Evaluation presents Basic Skills Achievement, 1981-82 (BSA). The BSA answers the following questions: (1) How does AISD student achievement compare to student achievement nationwide? (2) How does AISD's 1981-82 student achievement compare to the achievement of students in past…

Conceptual and methodological issues in research on mindfulness and meditation.

PubMed

Davidson, Richard J; Kaszniak, Alfred W

2015-10-01

Both basic science and clinical research on mindfulness, meditation, and related constructs have dramatically increased in recent years. However, interpretation of these research results has been challenging. The present article addresses unique conceptual and methodological problems posed by research in this area. Included among the key topics is the role of first-person experience and how it can be best studied, the challenges posed by intervention research designs in which true double-blinding is not possible, the nature of control and comparison conditions for research that includes mindfulness or other meditation-based interventions, issues in the adequate description of mindfulness and related trainings and interventions, the question of how mindfulness can be measured, questions regarding what can and cannot be inferred from self-report measures, and considerations regarding the structure of study design and data analyses. Most of these topics are germane to both basic and clinical research studies and have important bearing on the future scientific understanding of mindfulness and meditation. (c) 2015 APA, all rights reserved).

Conceptual and Methodological Issues in Research on Mindfulness and Meditation

PubMed Central

Davidson, Richard J.; Kaszniak, Alfred W.

2015-01-01

Both basic science and clinical research on mindfulness, meditation, and related constructs has dramatically increased in recent years. However, interpretation of these research results has been challenging. The present article addresses unique conceptual and methodological problems posed by research in this area. Included among the key topics is the role of first person experience and how it can be best studied; the challenges posed by intervention research designs in which true double-blinding is not possible; the nature of control and comparison conditions for research that includes mindfulness or other meditation-based interventions; issues in the adequate description of mindfulness and related trainings and interventions; the question of how mindfulness can be measured; questions regarding what can and cannot be inferred from self-report measures; and considerations regarding the structure of study design and data analyses. Most of these topics are germane to both basic and clinical research studies and have important bearing on the future scientific understanding of mindfulness and meditation. PMID:26436310

ECOSYSTEM RESTORATION: MANAGEMENT PRACTICES FOR PROTECTING AND ENHANCING AQUATIC RESOURCES

EPA Science Inventory

This poster describes research that addresses the question: Which management practices are most successful for protection and restoration of ecological resources? The Ecosystem Restoration Research Program of EPA/ORD is designed to conduct basic and applied field research to eva...

Those Responsible for Approving Research Studies Have Poor Knowledge of Research Study Design: a Knowledge Assessment of Institutional Review Board Members.

PubMed

Mhaskar, Rahul; Pathak, Elizabeth Barnett; Wieten, Sarah; Guterbock, Thomas M; Kumar, Ambuj; Djulbegovic, Benjamin

2015-08-01

Institutional Review Board (IRB) members have a duty to protect the integrity of the research process, but little is known about their basic knowledge of clinical research study designs. A nationwide sample of IRB members from major US research universities completed a web-based questionnaire consisting of 11 questions focusing on basic knowledge about clinical research study designs. It included questions about randomized controlled trials (RCTs) and other observational research study designs. Potential predictors (age, gender, educational attainment, type of IRB, current IRB membership, years of IRB service, clinical research experience, and self-identification as a scientist) of incorrect answers were evaluated using multivariate logistic regression models. 148 individuals from 36 universities participated. The majority of participants, 68.9% (102/148), were holding a medical or doctoral degree. Overall, only 26.5% (39/148) of participants achieved a perfect score of 11. On the six-question subset addressing RCTs, 46.6% (69/148) had a perfect score. Most individual questions, and the summary model of overall quiz score (perfect vs. not perfect), revealed no significant predictors - indicating that knowledge deficits were not limited to specific subgroups of IRB members. For the RCT knowledge score there was one significant predictor: compared with MDs, IRB members without a doctoral degree were three times as likely to answer at least one RCT question incorrectly (Odds Ratio: 3.00, 95% CI 1.10-8.20). However, even among MD IRB members, 34.1% (14/41) did not achieve a perfect score on the six RCT questions. This first nationwide study of IRB member knowledge about clinical research study designs found significant knowledge deficits. Knowledge deficits were not limited to laypersons or community advocate members of IRBs, as previously suggested. Akin to widespread ethical training requirements for clinical researchers, IRB members should undergo systematic training on clinical research designs.

Using mixed methods research in medical education: basic guidelines for researchers.

PubMed

Schifferdecker, Karen E; Reed, Virginia A

2009-07-01

Mixed methods research involves the collection, analysis and integration of both qualitative and quantitative data in a single study. The benefits of a mixed methods approach are particularly evident when studying new questions or complex initiatives and interactions, which is often the case in medical education research. Basic guidelines for when to use mixed methods research and how to design a mixed methods study in medical education research are not readily available. The purpose of this paper is to remedy that situation by providing an overview of mixed methods research, research design models relevant for medical education research, examples of each research design model in medical education research, and basic guidelines for medical education researchers interested in mixed methods research. Mixed methods may prove superior in increasing the integrity and applicability of findings when studying new or complex initiatives and interactions in medical education research. They deserve an increased presence and recognition in medical education research.

A model for integrating clinical care and basic science research, and pitfalls of performing complex research projects for addressing a clinical challenge.

PubMed

Steck, R; Epari, D R; Schuetz, M A

2010-07-01

The collaboration of clinicians with basic science researchers is crucial for addressing clinically relevant research questions. In order to initiate such mutually beneficial relationships, we propose a model where early career clinicians spend a designated time embedded in established basic science research groups, in order to pursue a postgraduate qualification. During this time, clinicians become integral members of the research team, fostering long term relationships and opening up opportunities for continuing collaboration. However, for these collaborations to be successful there are pitfalls to be avoided. Limited time and funding can lead to attempts to answer clinical challenges with highly complex research projects characterised by a large number of "clinical" factors being introduced in the hope that the research outcomes will be more clinically relevant. As a result, the complexity of such studies and variability of its outcomes may lead to difficulties in drawing scientifically justified and clinically useful conclusions. Consequently, we stress that it is the basic science researcher and the clinician's obligation to be mindful of the limitations and challenges of such multi-factorial research projects. A systematic step-by-step approach to address clinical research questions with limited, but highly targeted and well defined research projects provides the solid foundation which may lead to the development of a longer term research program for addressing more challenging clinical problems. Ultimately, we believe that it is such models, encouraging the vital collaboration between clinicians and researchers for the work on targeted, well defined research projects, which will result in answers to the important clinical challenges of today. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

Research Designs and Special Education Research: Different Designs Address Different Questions

ERIC Educational Resources Information Center

Cook, Bryan G.; Cook, Lysandra

2016-01-01

The aim of this article is to provide practitioners and other nonresearchers a basic understanding of research designs to aid in appropriately interpreting and applying research findings in special education. Research design provides the blueprint for conducting a research study and shapes what kind of knowledge is generated by the study. We…

Approaches to the Nature of Educational Sloyd and Craft. Sloyd Competence in Nordic Culture. Part III. Research in Sloyd Education and Crafts Science B:2.

ERIC Educational Resources Information Center

Lindfors, Linnea, Ed.; Peltonen, Juhani, Ed.; Porko, Mia, Ed.

These nine articles deal with basic philosophical questions concerned with the general nature of sloyd or with the educational aspect of sloyd. (Sloyd, derived from a Swedish word, is an umbrella term for making or crafting things by hand.) They report research on cultural questions related to goals and contents, ranging from sociocultural…

Commercialization of basic research from within the university and return of value to the public

PubMed Central

Hammerstedt, Roy H; Blach, Edward L

2008-01-01

The responsibility to return “value” to those who support basic research is an obligatory part of accepting funds to support the research. This reality should, but now does not, impact planning and execution of all basic research from its earliest stages. Universities are becoming ever more important in their role in the accelerating quest of a national goal of transition to a “knowledge based economy.” As such, the complex organizational format of a university, laden with entrenched procedures of questionable utility, should be adjusted to identify the means to commercialize the small subset of projects that appear suitable for further development. Of special concern is the growing tendency to encourage academic “innovators” to develop spin-out companies “on the side.” While seductive in perceived simplicity, this is a difficult step and we believe that most such individuals are ill-suited to these activities. Not because of technical ability but because of lack of relevant management experience. We attempt to address that situation through a brief listing of some reasons why people “do research” and outline phases (steps) in moving from concept to application, including an overview of start-up and funding early-stage spin-outs. A discussion of the limits to applying results of basic research to enhancing sperm fertility in commodity and companion animals and humans is provided. Hurdles are so daunting that there is concern as to why anyone would attempt to translate basic observations into practical solutions; which in turn raises the question of why funding agencies should fund basic studies in the first place. PMID:18164880

What is Basic Research? Insights from Historical Semantics.

PubMed

Schauz, Désirée

2014-01-01

For some years now, the concept of basic research has been under attack. Yet although the significance of the concept is in doubt, basic research continues to be used as an analytical category in science studies. But what exactly is basic research? What is the difference between basic and applied research? This article seeks to answer these questions by applying historical semantics. I argue that the concept of basic research did not arise out of the tradition of pure science. On the contrary, this new concept emerged in the late 19th and early 20th centuries, a time when scientists were being confronted with rising expectations regarding the societal utility of science. Scientists used the concept in order to try to bridge the gap between the promise of utility and the uncertainty of scientific endeavour. Only after 1945, when United States science policy shaped the notion of basic research, did the concept revert to the older ideals of pure science. This revival of the purity discourse was caused by the specific historical situation in the US at that time: the need to reform federal research policy after the Second World War, the new dimension of ethical dilemmas in science and technology during the atomic era, and the tense political climate during the Cold War.

The Applied Behavior Analysis Research Paradigm and Single-Subject Designs in Adapted Physical Activity Research.

PubMed

Haegele, Justin A; Hodge, Samuel Russell

2015-10-01

There are basic philosophical and paradigmatic assumptions that guide scholarly research endeavors, including the methods used and the types of questions asked. Through this article, kinesiology faculty and students with interests in adapted physical activity are encouraged to understand the basic assumptions of applied behavior analysis (ABA) methodology for conducting, analyzing, and presenting research of high quality in this paradigm. The purposes of this viewpoint paper are to present information fundamental to understanding the assumptions undergirding research methodology in ABA, describe key aspects of single-subject research designs, and discuss common research designs and data-analysis strategies used in single-subject studies.

Learning Biology through Research Papers: A Stimulus for Question-Asking by High-School Students

PubMed Central

Brill, Gilat; Yarden, Anat

2003-01-01

Question-asking is a basic skill, required for the development of scientific thinking. However, the way in which science lessons are conducted does not usually stimulate question-asking by students. To make students more familiar with the scientific inquiry process, we developed a curriculum in developmental biology based on research papers suitable for high-school students. Since a scientific paper poses a research question, demonstrates the events that led to the answer, and poses new questions, we attempted to examine the effect of studying through research papers on students' ability to pose questions. Students were asked before, during, and after instruction what they found interesting to know about embryonic development. In addition, we monitored students' questions, which were asked orally during the lessons. Questions were scored according to three categories: properties, comparisons, and causal relationships. We found that before learning through research papers, students tend to ask only questions of the properties category. In contrast, students tend to pose questions that reveal a higher level of thinking and uniqueness during or following instruction with research papers. This change was not observed during or following instruction with a textbook. We suggest that learning through research papers may be one way to provide a stimulus for question-asking by high-school students and results in higher thinking levels and uniqueness. PMID:14673492

The career goals of nurses in some health care settings in Gauteng.

PubMed

Jooste, K

2005-08-01

In nursing, purposeful career planning is essential if nurse practitioners want to make the right decisions about their work in order to strive towards and accomplish a meaningful quality of working life. Nurses should identify their career goals to be able to investigate their different career opportunities in their field of interest and direct their work according to a work strategy for years ahead. The purpose of this study was to explore and describe the career goals of post-basic nursing students with the aim of describing management strategies to guide the future career of post-basic nursing students in climbing the career ladder effectively and obtaining their set career goals. An explorative, descriptive, qualitative design was selected where the researcher worked inductively to explore and describe the needs (goals) and future planned actions of the participants regarding their career management as viewed for a period of five years. The researcher purposively and conveniently identified the sample as all the post-basic nursing students, namely 250 students, who were registered for the first, second and third year of nursing management courses in that period at a South African residential university. Two structured, open questions were developed. Each participant received the questions in writing and was asked to answer them. The QSR NUD*IST program was used for the qualitative management (categorization) of data. The results of the research questions related to five categories, namely becoming empowered, being promoted, being educated and professionally developed, partaking in research and taking up new projects.

Cystic fibrosis research topics featured at the 14th ECFS Basic Science Conference: Chairman's summary.

PubMed

Mall, Marcus A; Hwang, Tzyh-Chang; Braakman, Ineke

2018-03-01

In recent years, tremendous progress has been made in the development of novel drugs targeting the basic defect in patients with cystic fibrosis (CF). This breakthrough is based on a solid foundation of knowledge on CFTR's function in health and how mutations in CFTR cause CF multi-organ disease. This knowledge has been collected and continuously expanded by an active and persistent CF research community and has paved the way for precision medicine for CF. Since 2004, the European Cystic Fibrosis Society (ECFS) has held an annual Basic Science Conference that has evolved as an international forum for interdisciplinary discussion of hot topics and unsolved questions related to CF research. This Special Issue reviews CF research topics featured at the 14th ECFS Basic Science Conference and provides an up-to-date overview of recent progress in our understanding of CFTR structure and function, disease mechanisms implicated in airway mucus plugging, inflammation and abnormal host-pathogen interactions, and advancements with enhanced cell and animal model systems and breakthrough therapies directed at mutant CFTR or alternative targets. In addition, this Special Issue also identifies a number of fundamental questions and hurdles that still have to be overcome to realize the full potential of precision medicine and develop transformative therapies for all patients with CF. Copyright © 2017 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Cognitive Research and Elementary Science Instruction: From the Laboratory, to the Classroom, and Back

ERIC Educational Resources Information Center

Klahr, David; Li, Junlei

2005-01-01

Can cognitive research generate usable knowledge for elementary science instruction? Can issues raised by classroom practice drive the agenda of laboratory cognitive research? Answering yes to both questions, we advocate building a reciprocal interface between basic and applied research. We discuss five studies of the teaching, learning, and…

Research projects in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016): a cohort study.

PubMed

Goldenberg, Neil M; Steinberg, Benjamin E; Rutka, James T; Chen, Robert; Cabral, Val; Rosenblum, Norman D; Kapus, Andras; Lee, Warren L

2016-01-01

Physicians have traditionally been at the forefront of medical research, bringing clinical questions to the laboratory and returning with ideas for treatment. However, we have anecdotally observed a decline in the popularity of basic science research among trainees. We hypothesized that fewer resident physicians have been pursuing basic science research training over time. We examined records from residents in the Surgeon-Scientist and Clinician-Investigator programs at the University of Toronto (1987-2016). Research by residents was categorized independently by 2 raters as basic science, clinical epidemiology or education-related based on the title of the project, the name of the supervisor and Pubmed searches. The study population was divided into quintiles of time, and the proportion pursuing basic science training in each quintile was calculated. Agreement between the raters was 100%; the categorization of the research topic remained unclear in 9 cases. The proportion of trainees pursuing basic science training dropped by 60% from 1987 to 2016 ( p = 0.005). Significantly fewer residents in the Surgeon-Scientist and Clinician-Investigator Programs at the University of Toronto are pursuing training in the basic sciences as compared with previous years.

The Utility of Single Subject Design Research

ERIC Educational Resources Information Center

Bennett, Kyle D.

2016-01-01

Single subject design (SSD) research is a quantitative approach used to investigate basic and applied research questions. It has been used for decades to examine issues of social importance such as those related to general and special education strategies, therapeutic approaches in mental health, community health practices, safety, and business…

Are Online Quizzes an Effective Tool for Mastering Basic Algebra?

ERIC Educational Resources Information Center

Read, Wayne; Higgins, Patrick

2012-01-01

On-line quizzes are used to help first year University Mathematics students identify weaknesses in their basic skills and improve them. Quizzes developed as a formative tool have been utilised at JCU [James Cook University] for eight years. However, before this research no-one has questioned the effectiveness of quizzes for this task. We present a…

The Not So Common Sense: Differences in How People Judge Social and Political Life.

ERIC Educational Resources Information Center

Rosenberg, Shawn W.

This interdisciplinary book challenges two basic assumptions that orient much contemporary social scientific thinking. Offering theory and empirical research, the book rejects the classic liberal view that people share a basic common sense or rationality; while at the same time, it questions the view of contemporary social theory that meaning is…

Visual Basic Programming Impact on Cognitive Style of College Students: Need for Prerequisites

ERIC Educational Resources Information Center

White, Garry L.

2012-01-01

This research investigated the impact learning a visual programming language, Visual Basic, has on hemispheric cognitive style, as measured by the Hemispheric Mode Indicator (HMI). The question to be answered is: will a computer programming course help students improve their cognitive abilities in order to perform well? The cognitive styles for…

The Universal Basic Education Programme and Female Trafficking in South-South, Nigeria

ERIC Educational Resources Information Center

Ogonor, Bridget O.; Osunde, Austin U.

2007-01-01

The study investigated the impact of the Universal Basic Education (UBE) programme on the phenomenon of female trafficking in South-South Nigeria. To this end, six research questions were raised. These revolved around: (i) resource situation and adequacy of training provided for repatriated trafficked victims in the service provider centre; (ii)…

[Research on basic questions of intellectual property rights of acupuncture and moxibustion].

PubMed

Dong, Guo-Feng; Wu, Xiao-Dong; Han, Yan-Jing; Meng, Hong; Wang, Xin

2011-12-01

Along with the modernization and internationalization of acupuncture-moxibustion (acu-moxibustion), the issue of intellectual property rights has been becoming prominent and remarkable increasingly. In the present paper, the authors explain the basic issues of acu-moxibustion learning from the concept, scope, subject, object, contents and acquisition way of intellectual property rights. To make clear these questions will help us inherit and carry forward the existing civilization achievements of acu-moxibustion, and unceasingly bring forth new ideas and further improvement in clinical application, so as to serve the people's health in a better way.

Basic research needed for stimulating the development of behavioral technologies

PubMed Central

Mace, F. Charles

1994-01-01

The costs of disconnection between the basic and applied sectors of behavior analysis are reviewed, and some solutions to these problems are proposed. Central to these solutions are collaborations between basic and applied behavioral scientists in programmatic research that addresses the behavioral basis and solution of human behavior problems. This kind of collaboration parallels the deliberate interactions between basic and applied researchers that have proven to be so profitable in other scientific fields, such as medicine. Basic research questions of particular relevance to the development of behavioral technologies are posed in the following areas: response allocation, resistance to change, countercontrol, formation and differentiation/discrimination of stimulus and response classes, analysis of low-rate behavior, and rule-governed behavior. Three interrelated strategies to build connections between the basic and applied analysis of behavior are identified: (a) the development of nonhuman animal models of human behavior problems using operations that parallel plausible human circumstances, (b) replication of the modeled relations with human subjects in the operant laboratory, and (c) tests of the generality of the model with actual human problems in natural settings. PMID:16812734

Analysis of the basic science section of the orthopaedic in-training examination.

PubMed

Sheibani-Rad, Shahin; Arnoczky, Steven Paul; Walter, Norman E

2012-08-01

Since 1963, the Orthopaedic In-Training Examination (OITE) has been administered to orthopedic residents to assess residents' knowledge and measure the quality of teaching within individual programs. The OITE currently consists of 275 questions divided among 12 domains. This study analyzed all OITE basic science questions between 2006 and 2010. The following data were recorded: number of questions, question taxonomy, category of question, type of imaging modality, and recommended journal and book references. Between 2006 and 2010, the basic science section constituted 12.2% of the OITE. The assessment of taxonomy classification showed that recall-type questions were the most common, at 81.4%. Imaging modalities typically involved questions on radiographs and constituted 6.2% of the OITE basic science section. The majority of questions were basic science questions (eg, genetics, cell replication, and bone metabolism), with an average of 26.4 questions per year. The Journal of Bone & Joint Surgery (American Volume) and the American Academy of Orthopaedic Surgeons' Orthopaedic Basic Science were the most commonly and consistently cited journal and review book, respectively. This study provides the first review of the question content and recommended references of the OITE basic science section. This information will provide orthopedic trainees, orthopedic residency programs, and the American Academy of Orthopaedic Surgeons Evaluation Committee valuable information related to improving residents' knowledge and performance and optimizing basic science educational curricula. Copyright 2012, SLACK Incorporated.

Design Requirements for a Decision Support System for the Dynamic Retasking of Electronic Combat Assets.

DTIC Science & Technology

1988-03-01

primary mission was not pursued. The question of the *t employment and retasking of EC assets is basically a question of command and control, though...The] primary function of command is deploying and maneuvering forces or other sources of potential power to be in the best possible position to...unstructured, and multivariable problem. Research Objective The primary objective of this research is to develop an initial set requirements for a decision

Children's Perceptions of Health and Illness: Images and Lay Concepts in Preadolescence

ERIC Educational Resources Information Center

Piko, Bettina F.; Bak, Judit

2006-01-01

Despite a growing body of research into children's concepts of illness, many basic questions still remain. This study aims to describe 8- to 11-year olds' lay beliefs of health, illness, health promotion and disease prevention. Children responded to open-ended questions about health and illness by drawing and writing their responses. Two primary…

From the Laboratory to the Classroom: The Effects of Equivalence-Based Instruction on Neuroanatomy Competencies

ERIC Educational Resources Information Center

Fienup, Daniel M.; Mylan, Sanaa E.; Brodsky, Julia; Pytte, Carolyn

2016-01-01

Equivalence-based instruction (EBI) has been used to successfully teach college-level concepts in research laboratories, but few studies have examined the results of such instruction on classroom performance. The current study answered a basic question about the ordering of training stimuli as well as an applied question regarding the effects of…

Website for the Space Science Division

NASA Technical Reports Server (NTRS)

Schilling, James; DeVincenzi, Donald (Technical Monitor)

2002-01-01

The Space Science Division at NASA Ames Research Center is dedicated to research in astrophysics, exobiology, advanced life support technologies, and planetary science. These research programs are structured around Astrobiology (the study of life in the universe and the chemical and physical forces and adaptions that influence life's origin, evolution, and destiny), and address some of the most fundamental questions pursued by science. These questions examine the origin of life and our place in the universe. Ames is recognized as a world leader in Astrobiology. In pursuing our mission in Astrobiology, Space Science Division scientists perform pioneering basic research and technology development.

Research, the lifeline of medicine.

PubMed

Kornberg, A

1976-05-27

Advances in medicine spring from discoveries in physics, chemistry and biology. Among key contributions to the diagnosis, treatment and prevention of cardiovascular and pulmonary diseases, a recent Comroe-Dripps analysis shows two thirds to have been basic rather than applied research. Without a firm foundation in basic knowledge innovations perceived as advances prove hollow and collapse. Strong social, economic and political pressures now threaten acquisition of basic knowledge. Scientists feel driven to undertake excessively complex problems and gamble against the historical record that science generally progresses by tackling discrete and well defined questions. Regardless of circumstances, professional standards require the physician and scientist to be creative and enlarge the fund of knowledge.

Power and Method: Political Activism and Educational Research. Critical Social Thought Series.

ERIC Educational Resources Information Center

Gitlin, Andrew, Ed.

This book scrutinizes some basic assumptions about educational research with the aim that such research may act more powerfully on those persistent and important problems of our schools surrounding issues of race, class, and gender. In particular, the 13 essays in this book examine how power is infused in research by addressing such questions as…

Enhancing Education for Deaf Children: Research into Practice and Back Again

ERIC Educational Resources Information Center

Swanwick, Ruth; Marschark, Marc

2010-01-01

Decades of research on educational and basic scientific questions relating to deaf children have yielded a wealth of knowledge about how they learn and develop as thinking, social, problem-solving individuals. However, we currently lack channels for communication from teachers to researchers about the priorities in education and from researchers…

A Framework for the Ethics of Open Education

ERIC Educational Resources Information Center

Farrow, Robert

2016-01-01

What difference does openness make to the ethics of teaching and research? This paper approaches this question both from the perspective of research into the use of open educational resources (OER) in teaching and learning. An outline of the nature and importance of ethics in education research is provided before the basic principles of research…

The Role of School Culture and Basic Psychological Needs on Iranian Adolescents' Academic Alienation: A Multi-Level Examination

ERIC Educational Resources Information Center

Mahmoudi, Hojjat; Brown, Monica R.; Amani Saribagloo, Javad; Dadashzadeh, Shiva

2018-01-01

This aim of this current research was a multi-level analysis of the relationship between school culture, basic psychological needs, and adolescents' academic alienation. One thousand twenty-nine (N = 1,029) high school students from Qom City were randomly selected through a multi-phase cluster sampling method and answered questions regarding…

Evaluating the Effects of Basic Skills Mathematics Placement on Academic Outcomes of Community College Students

ERIC Educational Resources Information Center

Melguizo, Tatiana; Bo, Hans; Prather, George; Kim, Bo

2011-01-01

The main objective of the authors' proposed study is to evaluate the effectiveness of math placement policies for entering community college students on these students' academic success in math, and their transfer and graduation rates. The main research question that guides the proposed study is: What are the effects of various basic skills…

Evaluation of Achievement of Universal Basic Education (UBE) in Delta State

ERIC Educational Resources Information Center

Osadebe, P. U.

2014-01-01

The study evaluated the objectives of the Universal Basic Education (UBE) programme in Delta State. It considered the extent to which each objective was achieved. A research question on the extent to which the UBE objectives were achieved guided the study. Two hypotheses were tested. A sample of 300 students was randomly drawn through the use of…

The Practice and Challenges of Implementing Critical Thinking Skills in Omani Post-Basic EFL Classrooms

ERIC Educational Resources Information Center

Al-Kindi, Naeema Saleh; AL-Mekhlafi, Abdo Mohammed

2017-01-01

The purpose of the current study is to investigate post-basic English teachers' practice of critical thinking skills and the challenges they face while teaching skills in EFL classrooms. Three research questions were investigated to achieve this purpose: 1--To what extent do EFL teachers use classroom behaviors that nurture critical thinking at…

Effect of Improvised Instructional Materials on Students' Achievement in Geometry at the Upper Basic Education Level in Makurdi Metropolis, Benue State, Nigeria

ERIC Educational Resources Information Center

Iji, C. O.; Ogbole, P. O.; Uka, N. K.

2014-01-01

Among all approaches aimed at reducing poor mathematics achievement among the students, adoption of appropriate methods of teaching appears to be more rewarding. In this study, improvised instructional materials were used to ascertain students' geometry achievement at the upper basic education one. Two research questions were asked with associated…

Adequacy of Material Resources Required for Effective Implementation of Upper Basic Education Business Studies Curriculum in Nigeria

ERIC Educational Resources Information Center

Okoli, B. E.; Okorie, Ogbonnaya

2015-01-01

This work is a descriptive survey of the adequacy of the material resources required for effective implementation of upper basic education business studies curriculum in Ebonyi State. Two research questions and two hypotheses guided the study. The entire population of two hundred and forty-one (241) business studies teachers were used for the…

34 CFR 97.103 - Assuring compliance with this policy-research conducted or supported by any Federal Department or...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Subjects (Basic ED Policy for Protection of Human Research Subjects) § 97.103 Assuring compliance with this..., appropriate for the research in question, on file with the Office for Human Research Protections, HHS, or any... Human Research Protections, (HHS), or any successor office. (b) Departments and agencies will conduct or...

Origin of life. The role of experiments, basic beliefs, and social authorities in the controversies about the spontaneous generation of life and the subsequent debates about synthesizing life in the laboratory.

PubMed

Deichmann, Ute

2012-01-01

For centuries the question of the origin of life had focused on the question of the spontaneous generation of life, at least primitive forms of life, from inanimate matter, an idea that had been promoted most prominently by Aristotle. The widespread belief in spontaneous generation, which had been adopted by the Church, too, was finally abandoned at the beginning of the twentieth century, when the question of the origin of life became related to that of the artificial generation of life in the laboratory. This paper examines the role of social authorities, researchers' basic beliefs, crucial experiments, and scientific advance in the controversies about spontaneous generation from the seventeenth to the nineteenth centuries and analyzes the subsequent debates about the synthesis of artificial life in the changing scientific contexts of the nineteenth and early-twentieth centuries. It shows that despite the importance of social authorities, basic beliefs, and crucial experiments scientific advances, especially those in microbiology, were the single most important factor in the stepwise abandoning of the doctrine of spontaneous generation. Research on the origin of life and the artificial synthesis of life became scientifically addressed only when it got rid of the idea of constant smooth transitions between inanimate matter and life and explored possible chemical and physical mechanisms of the specificity of basic molecules and processes of life.

[Basic research during residency in Israel: is change needed?].

PubMed

Fishbain, Dana; Shoenfeld, Yehuda; Ashkenazi, Shai

2013-10-01

A six-month research period is a mandatory part of the residency training program in most basic specialties in Israel and is named: the "basic science period". This is the only period in an Israeli physician's medical career which is dedicated strictly to research, accentuating the importance of medical research to the quality of training and level of medicine in Israel. From another point of view, one may argue that in an era of shortage of physicians on the one hand and the dizzying rate of growth in medical knowledge on the other hand, every moment spent training in residency is precious, therefore, making the decision of whether to dedicate six months for research becomes ever more relevant. This question is currently raised for discussion once again by the Scientific Council of the Israeli Medical Association. The Scientific Council lately issued a call for comments sent to all Israeli physicians, asking their opinion on several key questions regarding basic science research. Learning the public's opinion will serve as a background for discussion. A total of 380 physicians responded to the call and specified their standpoint on the subject, among them heads of departments, units and clinics, senior physicians and residents. The findings pointed to strong support in maintaining the research period as part of residency training due to its importance to medical training and medicine, although half the respondents supported the use of various alternative formats for research together with the existing format. Those alternative format suggestions will be thoroughly reviewed. A smaller group of respondents supported allowing residents a choice between two tracks--with or without a research period, and only a few were in favor of canceling the research requirement altogether. The writers maintain that the "basic science period" of research during residency training is vital and its contribution to the high level of specialists and high level of medicine requires its conservation. Nevertheless, alternative formats which might be suitable for some residents should be considered, and auxiliary tools to help residents fulfill their potential in research and raise the quality of written research papers should be constructed.

78 FR 75353 - Agency Information Collection Activities: Proposed Collection: Public Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-11

... cognitive interviews, focus groups, usability tests, field tests/pilot interviews, and experimental research... as more basic research on response errors in surveys. HRSA staff use various techniques to evaluate... interview structure consists of respondents first answering a draft survey question and then providing...

Feminism, Communication and the Politics of Knowledge.

ERIC Educational Resources Information Center

Gallagher, Margaret

Recent retrieval of pre-nineteenth century feminist thought provides a telling lesson in the politics of knowledge creation and control. From a feminist perspective, very little research carried out within the critical research paradigm questions the "basic assumptions, conventional wisdom, media myths and the accepted way of doing…

The Development and Evaluation of Software to Foster Professional Development in Educational Assessment

ERIC Educational Resources Information Center

Benton, Morgan C.

2008-01-01

This dissertation sought to answer the question: Is it possible to build a software tool that will allow teachers to write better multiple-choice questions? The thesis proceeded from the finding that the quality of teaching is very influential in the amount that students learn. A basic premise of this research, then, is that improving teachers…

Arthropod genomics research in the United States Department of Agriculture-Agricultural Research Service: Applications of RNA interference and CRISPR gene editing technologies in pest control

USDA-ARS?s Scientific Manuscript database

The Agricultural Research Service (ARS) is the intramural research agency of the United States Department of Agriculture (USDA) which addresses basic scientific questions and develops applied solutions to a range of agricultural problems, and in doing so protects national food security and supports ...

Creativity and Education: An American Retrospective

ERIC Educational Resources Information Center

Feldman, David Henry; Benjamin, Ann C.

2006-01-01

Although early childhood education in America has always had the creative child at the core of its approach, the field itself has generated little systematic research on the topic. In contrast, the scholarly field of creativity studies, with its focus on basic research and theoretical questions, has impacted education only slightly. Creativity and…

Analysis and Interpretation of Findings Using Multiple Regression Techniques

ERIC Educational Resources Information Center

Hoyt, William T.; Leierer, Stephen; Millington, Michael J.

2006-01-01

Multiple regression and correlation (MRC) methods form a flexible family of statistical techniques that can address a wide variety of different types of research questions of interest to rehabilitation professionals. In this article, we review basic concepts and terms, with an emphasis on interpretation of findings relevant to research questions…

Innovation Learning in Comprehensive Education?

ERIC Educational Resources Information Center

Lindfors, Eila; Hilmola, Antti

2016-01-01

The goal of this article is to clarify the concept of innovation and by presenting a research on the basic education outcome assessment data from an innovation learning perspective, answer to a question: Do students learn innovation in comprehensive education? The empirical information in this research is based on data collected in the national…

21 CFR 50.25 - Elements of informed consent.

Code of Federal Regulations, 2010 CFR

2010-04-01

... Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROTECTION OF HUMAN SUBJECTS Informed Consent of Human Subjects § 50.25 Elements of informed consent. (a) Basic... pertinent questions about the research and research subjects' rights, and whom to contact in the event of a...

[Methodologic developmental principles of standardized surveys within the scope of social gerontologic studies].

PubMed

Bansemir, G

1987-01-01

The conception and evaluation of standardized oral or written questioning as quantifying instruments of research orientate by the basic premises of Marxist-Leninist theory of recognition and general scientific logic. In the present contribution the socio-gerontological research process is outlined in extracts. By referring to the intrinsic connection between some of its essential components--problem, formation of hypotheses, obtaining indicators/measurement, preliminary examination, evaluation-as well as to typical errors and (fictitious) examples of practical research, this contribution contrasts the natural, apparently uncomplicated course of structured questioning with its qualitative methodological fundamentals and demands.

The qualitative orientation in medical education research.

PubMed

Cleland, Jennifer Anne

2017-06-01

Qualitative research is very important in educational research as it addresses the "how" and "why" research questions and enables deeper understanding of experiences, phenomena and context. Qualitative research allows you to ask questions that cannot be easily put into numbers to understand human experience. Getting at the everyday realities of some social phenomenon and studying important questions as they are really practiced helps extend knowledge and understanding. To do so, you need to understand the philosophical stance of qualitative research and work from this to develop the research question, study design, data collection methods and data analysis. In this article, I provide an overview of the assumptions underlying qualitative research and the role of the researcher in the qualitative process. I then go on to discuss the type of research objectives which are common in qualitative research, then introduce the main qualitative designs, data collection tools, and finally the basics of qualitative analysis. I introduce the criteria by which you can judge the quality of qualitative research. Many classic references are cited in this article, and I urge you to seek out some of these further reading to inform your qualitative research program.

The qualitative orientation in medical education research

PubMed Central

2017-01-01

Qualitative research is very important in educational research as it addresses the “how” and “why” research questions and enables deeper understanding of experiences, phenomena and context. Qualitative research allows you to ask questions that cannot be easily put into numbers to understand human experience. Getting at the everyday realities of some social phenomenon and studying important questions as they are really practiced helps extend knowledge and understanding. To do so, you need to understand the philosophical stance of qualitative research and work from this to develop the research question, study design, data collection methods and data analysis. In this article, I provide an overview of the assumptions underlying qualitative research and the role of the researcher in the qualitative process. I then go on to discuss the type of research objectives which are common in qualitative research, then introduce the main qualitative designs, data collection tools, and finally the basics of qualitative analysis. I introduce the criteria by which you can judge the quality of qualitative research. Many classic references are cited in this article, and I urge you to seek out some of these further reading to inform your qualitative research program. PMID:28597869

Identification of translational dermatology research priorities in the U.K.: results of an electronic Delphi exercise.

PubMed

Healy, E; Brown, S J; Langan, S M; Nicholls, S G; Shams, K; Reynolds, N J

2015-11-01

Translational research is the direct application of basic and applied research to patient care. It is estimated that there are at least 2000 different skin diseases; thus, there are considerable challenges in seeking to undertake research on each of these disorders. This electronic Delphi (e-Delphi) exercise was conducted in order to generate a list of translational dermatology research questions that are regarded as a priority for further investigations. During the first phase of the e-Delphi exercise, 228 research questions were generated by an expert panel that included clinical academic dermatologists, clinical dermatologists, nonclinical scientists, dermatology trainees and representatives from patient support groups. Following completion of the second and third phases, 40 questions on inflammatory skin disease, 20 questions on structural skin disorders/genodermatoses, 37 questions on skin cancer and eight miscellaneous questions were designated as priority translational dermatology research questions (PRQs). In addition to PRQs on a variety of disease areas (including multiple PRQs on psoriasis, eczema, squamous cell carcinoma and melanoma), there were a number of cross-cutting themes that identified a need to investigate mechanisms/pathogenesis of disease and the necessity to improve treatments for patients with skin disease. It is predicted that this list of PRQs will help to provide a strategic direction for translational dermatology research in the U.K. and that addressing this list of questions will ultimately provide clinical benefit for substantial numbers of patients with skin disorders. © 2015 British Association of Dermatologists.

Identification of Translational Dermatology Research Priorities in the UK; Results of an e-Delphi Exercise

PubMed Central

Healy, E.; Reynolds, N.J.

2016-01-01

Summary Background Translational research is the direct application of basic and applied research to patient care. It is estimated that there are at least 2,000 different skin diseases, thus there are considerable challenges in seeking to undertake research on each of these disorders. Objective This eDelphi exercise was conducted in order to generate a list of translational dermatology research questions which are regarded as a priority for further investigations. Results During the first phase of the eDelphi, 228 research questions were generated by an expert panel which included clinical academic dermatologists, clinical dermatologists, non-clinical scientists, dermatology trainees and representatives from patient support groups. Following completion of the second and third phases, 40 questions on inflammatory skin disease, 20 questions on structural skin disorders / genodermatoses, 37 questions on skin cancer and 8 miscellaneous questions were designated as priority translational dermatology research questions (PRQs). In addition to PRQs on a variety of disease areas (including multiple PRQs on psoriasis, eczema, squamous cell carcinoma (SCC) and melanoma), there were a number of cross-cutting themes which identified a need to investigate mechanisms / pathogenesis of disease and the necessity to improve treatments for patients with skin disease. Conclusion It is predicted that this list of PRQs will help to provide a strategic direction for translational dermatology research in the UK and that addressing this list of questions will ultimately provide clinical benefit for substantial numbers of subjects with skin disorders. PMID:26149834

A Question-Answer System for Mobile Devices in Lecture-Based Instruction: A Qualitative Analysis of Student Engagement and Learning

ERIC Educational Resources Information Center

Hatun Atas, Amine; Delialioglu, Ömer

2018-01-01

The aim of this study was to explore the opinions, perceptions and evaluations of students about their experiences with a question-answer system used on mobile devices in a lecture-based course. Basic qualitative research method was employed in this study to understand how students made sense of their experiences during the instruction. The…

The Dispositions of Elementary School Children of Individualistic and Collectivist Cultures Who Are Intrinsically Motivated to Seek Information

ERIC Educational Resources Information Center

Crow, Sherry R.; Kastello, Lisa

2016-01-01

This paper is based on two studies conducted in Colorado Springs, Colorado, in 2008 and in Kampala, Uganda, in 2014. The basic research question addressed in both studies was: "What are the experiences in the lives of upper elementary-aged children that foster an intrinsic motivation to seek information?" The secondary question was:…

Design of Chemical Literacy Assessment by Using Model of Educational Reconstruction (MER) on Solubility Topic

NASA Astrophysics Data System (ADS)

Yusmaita, E.; Nasra, Edi

2018-04-01

This research aims to produce instrument for measuring chemical literacy assessment in basic chemistry courses with solubility topic. The construction of this measuring instrument is adapted to the PISA (Programme for International Student Assessment) problem’s characteristics and the Syllaby of Basic Chemistry in KKNI-IndonesianNational Qualification Framework. The PISA is a cross-country study conducted periodically to monitor the outcomes of learners' achievement in each participating country. So far, studies conducted by PISA include reading literacy, mathematic literacy and scientific literacy. Refered to the scientific competence of the PISA study on science literacy, an assessment designed to measure the chemical literacy of the chemistry department’s students in UNP. The research model used is MER (Model of Educational Reconstruction). The validity and reliability values of discourse questions is measured using the software ANATES. Based on the acquisition of these values is obtained a valid and reliable chemical literacy questions.There are seven question items limited response on the topic of solubility with valid category, the acquisition value of test reliability is 0,86, and has a difficulty index and distinguishing good

Values in translation: how asking the right questions can move translational science toward greater health impact.

PubMed

Kelley, Maureen; Edwards, Kelly; Starks, Helene; Fullerton, Stephanie M; James, Rosalina; Goering, Sara; Holland, Suzanne; Disis, Mary L; Burke, Wylie

2012-12-01

The speed and effectiveness of current approaches to research translation are widely viewed as disappointing given small gains in real population health outcomes despite huge investments in basic and translational science. We identify critical value questions-ethical, social, economic, and cultural-that arise at moments throughout the research pathway. By making these questions visible, and promoting discussion of them with diverse stakeholders, we can facilitate handoffs along the translational pathway and increase uptake of effective interventions. Who is involved with those discussions will determine which research projects, populations, and methods get prioritized. We argue that some upfront investment in community and interdisciplinary engagement, shaped by familiar questions in ethics, social justice, and cultural knowledge, can save time and resources in the long run because interventions and strategies will be aimed in the right direction, that is, toward health improvements for all. © 2012 Wiley Periodicals, Inc.

A research agenda for gastrointestinal and endoscopic surgery.

PubMed

Urbach, D R; Horvath, K D; Baxter, N N; Jobe, B A; Madan, A K; Pryor, A D; Khaitan, L; Torquati, A; Brower, S T; Trus, T L; Schwaitzberg, S

2007-09-01

Development of a research agenda may help to inform researchers and research-granting agencies about the key research gaps in an area of research and clinical care. The authors sought to develop a list of research questions for which further research was likely to have a major impact on clinical care in the area of gastrointestinal and endoscopic surgery. A formal group process was used to conduct an iterative, anonymous Web-based survey of an expert panel including the general membership of the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES). In round 1, research questions were solicited, which were categorized, collapsed, and rewritten in a common format. In round 2, the expert panel rated all the questions using a priority scale ranging from 1 (lowest) to 5 (highest). In round 3, the panel re-rated the 40 questions with the highest mean priority score in round 2. A total of 241 respondents to round 1 submitted 382 questions, which were reduced by a review panel to 106 unique questions encompassing 33 topics in gastrointestinal and endoscopic surgery. In the two successive rounds, respectively, 397 and 385 respondents ranked the questions by priority, then re-ranked the 40 questions with the highest mean priority score. High-priority questions related to antireflux surgery, the oncologic and immune effects of minimally invasive surgery, and morbid obesity. The question with the highest mean priority ranking was: "What is the best treatment (antireflux surgery, endoluminal therapy, or medication) for GERD?" The second highest-ranked question was: "Does minimally invasive surgery improve oncologic outcomes as compared with open surgery?" Other questions covered a broad range of research areas including clinical research, basic science research, education and evaluation, outcomes measurement, and health technology assessment. An iterative, anonymous group survey process was used to develop a research agenda for gastrointestinal and endoscopic surgery consisting of the 40 most important research questions in the field. This research agenda can be used by researchers and research-granting agencies to focus research activity in the areas most likely to have an impact on clinical care, and to appraise the relevance of scientific contributions.

Characteristics of physicians engaged in basic science: a questionnaire survey of physicians in basic science departments of a medical school in Japan.

PubMed

Yamazaki, Yuka; Uka, Takanori; Shimizu, Haruhiko; Miyahira, Akira; Sakai, Tatsuo; Marui, Eiji

2012-09-01

The number of physicians engaged in basic science and teaching is sharply decreasing in Japan. To alleviate this shortage, central government has increased the quota of medical students entering the field. This study aimed to determine the characteristics of physicians who are engaged in basic science in efforts to recruit talent. A questionnaire was distributed to all 30 physicians in the basic science departments of Juntendo University School of Medicine. Question items inquired about sex, years since graduation, years between graduation and time entering basic science, clinical experience, recommending the career to medical students, expected obstacles to students entering basic science, efforts to inspire students in research, increased number of lectures and practical training sessions on research, and career choice satisfaction. Correlations between the variables were examined using χ(2) tests. Overall, 26 physicians, including 7 female physicians, returned the questionnaire (response rate 86.7%). Most physicians were satisfied with their career choice. Medical students were deemed not to choose basic science as their future career, because they aimed to become clinicians and because they were concerned about salary. Women physicians in basic science departments were younger than men. Women physicians also considered themselves to make more efforts in inspiring medical students to be interested in research. Moreover, physicians who became basic scientists earlier in their career wanted more research-related lectures in medical education. Improving physicians' salaries in basic science is important to securing talent. In addition, basic science may be a good career path for women physicians to follow.

PhysioNet: physiologic signals, time series and related open source software for basic, clinical, and applied research.

PubMed

Moody, George B; Mark, Roger G; Goldberger, Ary L

2011-01-01

PhysioNet provides free web access to over 50 collections of recorded physiologic signals and time series, and related open-source software, in support of basic, clinical, and applied research in medicine, physiology, public health, biomedical engineering and computing, and medical instrument design and evaluation. Its three components (PhysioBank, the archive of signals; PhysioToolkit, the software library; and PhysioNetWorks, the virtual laboratory for collaborative development of future PhysioBank data collections and PhysioToolkit software components) connect researchers and students who need physiologic signals and relevant software with researchers who have data and software to share. PhysioNet's annual open engineering challenges stimulate rapid progress on unsolved or poorly solved questions of basic or clinical interest, by focusing attention on achievable solutions that can be evaluated and compared objectively using freely available reference data.

What Coping Strategies and Support Mechanisms Have Elementary Teachers Found Most Effective?

ERIC Educational Resources Information Center

Byrd, Kristie M.

2017-01-01

This basic qualitative research study explored the lives of 14 elementary teachers in their classroom environment to answer two central research questions which are: what coping strategies do teachers find most effective and what coping mechanisms provided by administration helps them cope with classroom stress? Data were collected through…

Diversity Recruiting: Overview of Practices and Benchmarks. CERI Research Brief 4-2013

ERIC Educational Resources Information Center

Gardner, Phil

2013-01-01

Little information exists on the basic elements of diversity recruiting on college campuses. A set of questions was developed for the Collegiate Employment Research Institute's (CERI's) annual college hiring survey that attempted to capture the current practices and benchmarks being employed by organizations in their diversity recruiting programs.…

Designing Structured Interviews for Educational Research. ERIC/AE Digest.

ERIC Educational Resources Information Center

ERIC Clearinghouse on Assessment and Evaluation, Washington, DC.

This digest reviews the basic building blocks of a structured interview, points out some of the pitfalls in interviewing, and suggests ways for researchers to avoid these difficulties to produce questions that have the best possibility of generating reliable and accurate data on the topics of interest. The data collection instrument is a document…

The Effects of POWERSOURCE[C] Intervention on Student Understanding of Basic Mathematical Principles. CRESST Report 763

ERIC Educational Resources Information Center

Phelan, Julia; Choi, Kilchan; Vendlinski, Terry; Baker, Eva L.; Herman, Joan L.

2009-01-01

This report describes results from field-testing of POWERSOURCE[C] formative assessment alongside professional development and instructional resources. The researchers at the National Center for Research, on Evaluation, Standards, & Student Testing (CRESST) employed a randomized, controlled design to address the following question: Does the…

Educational Quality in Music Teacher Education: Components of a Foundation for Research

ERIC Educational Resources Information Center

Johansen, Geir

2007-01-01

Increasing demands for educational quality in higher education affect both higher music education and music teacher education. A theoretical framework is needed if we are to question what is meant by "educational quality" in the latter. To establish programs for quality development and assessment requires basic subject-specific research on the…

"Research-Based" and "Profession-Oriented" as Prominent Knowledge Discourses in Curriculum Restructuring of Professional Programs

ERIC Educational Resources Information Center

Afdal, Hilde W.

2017-01-01

This article questions what kind of actors become involved and analyzes what forms of knowledge are activated, when discourses such as "research-based" and "profession-oriented" become basic preconditions in national curriculum change processes in Norway. A "mapping" is conducted, comprised of actors and ideas, played…

Exploring Attractiveness of the Basic Sciences for Female Physicians.

PubMed

Yamazaki, Yuka; Fukushima, Shinji; Kozono, Yuki; Uka, Takanori; Marui, Eiji

2018-01-01

In Japan, traditional gender roles of women, especially the role of motherhood, may cause early career resignations in female physicians and a shortage of female researchers. Besides this gender issue, a general physician shortage is affecting basic science fields. Our previous study suggested that female physicians could be good candidates for the basic sciences because such work offers good work-life balance. However, the attractiveness for female physicians of working in the basic sciences, including work-life balance, is not known. In a 2012 nationwide cross-sectional questionnaire survey, female physicians holding tenured positions in the basic sciences at Japan's medical schools were asked an open-ended question about positive aspects of basic sciences that clinical medicine lacks, and we analyzed 58 respondents' comments. Qualitative analysis using the Kawakita Jiro method revealed four positive aspects: research attractiveness, priority on research productivity, a healthy work-life balance, and exemption from clinical duties. The most consistent positive aspect was research attractiveness, which was heightened by medical knowledge and clinical experience. The other aspects were double-edged swords; for example, while the priority on research productivity resulted in less gender segregation, it sometimes created tough competition, and while exemption from clinical duties contributed to a healthy work-life balance, it sometimes lowered motivation as a physician and provided unstable income. Overall, if female physicians lack an intrinsic interest in research and seek good work-life balance, they may drop out of research fields. Respecting and cultivating students' research interest is critical to alleviating the physician shortage in the basic sciences.

Basic Sciences Fertilizing Clinical Microbiology and Infection Management

PubMed Central

2017-01-01

Abstract Basic sciences constitute the most abundant sources of creativity and innovation, as they are based on the passion of knowing. Basic knowledge, in close and fertile contact with medical and public health needs, produces distinct advancements in applied sciences. Basic sciences play the role of stem cells, providing material and semantics to construct differentiated tissues and organisms and enabling specialized functions and applications. However, eventually processes of “practice deconstruction” might reveal basic questions, as in de-differentiation of tissue cells. Basic sciences, microbiology, infectious diseases, and public health constitute an epistemological gradient that should also be an investigational continuum. The coexistence of all these interests and their cross-fertilization should be favored by interdisciplinary, integrative research organizations working simultaneously in the analytical and synthetic dimensions of scientific knowledge. PMID:28859345

Multifunctional Thermal Structures Using Cellular Contact-Aided Complaint Mechanisms

DTIC Science & Technology

2016-10-31

control . During this research effort, designs of increasing sophistication consistently outstripped the ability to fabricate them. Basic questions...using   non -­dimensional  models   In continuing design research , a topology optimization approach was crafted to maximize the thermal performance of the...methods could conceivably produce the elegant but complex material and geometric designs contemplated. Continued research is needed to improve the

Multifunctional Thermal Structures Using Cellular Contract-Aided Complaint Mechanisms

DTIC Science & Technology

2017-01-26

control . During this research effort, designs of increasing sophistication consistently outstripped the ability to fabricate them. Basic questions...using   non -­dimensional  models   In continuing design research , a topology optimization approach was crafted to maximize the thermal performance of the...methods could conceivably produce the elegant but complex material and geometric designs contemplated. Continued research is needed to improve the

Assessment of Translational and Interdisciplinary Clinical Research at an Oklahoma Health Sciences Center

PubMed Central

Dao, Hanh Dung; Kota, Pravina; James, Judith A.; Stoner, Julie A.; Akins, Darrin R.

2015-01-01

Purpose In response to National Institutes of Health initiatives to improve translation of basic science discoveries we surveyed faculty to assess patterns of and barriers to translational research in Oklahoma. Methods An online survey was administered to University of Oklahoma Health Sciences Center, College of Medicine faculty, which included demographic and research questions. Results Responses were received from 126 faculty members (24%). Two-thirds spent ≥20% time on research; among these, 90% conduct clinical and translational research. Identifying funding; recruiting research staff and participants; preparing reports and agreements; and protecting research time were commonly perceived as at least moderate barriers to conducting research. While respondents largely collaborated within their discipline, clinical investigators were more likely than basic science investigators to engage in interdisciplinary research. Conclusion While engagement in translational research is common, specific barriers impact the research process. This could be improved through an expanded interdisciplinary collaboration and research support structure. PMID:26242016

The Sun to the Earth - and Beyond: A Decadal Research Strategy in Solar and Space Physics

NASA Technical Reports Server (NTRS)

2003-01-01

The sun is the source of energy for life on earth and is the strongest modulator of the human physical environment. In fact, the Sun's influence extends throughout the solar system, both through photons, which provide heat, light, and ionization, and through the continuous outflow of a magnetized, supersonic ionized gas known as the solar wind. While the accomplishments of the past decade have answered important questions about the physics of the Sun, the interplanetary medium, and the space environments of Earth and other solar system bodies, they have also highlighted other questions, some of which are long-standing and fundamental. The Sun to the Earth--and Beyond organizes these questions in terms of five challenges that are expected to be the focus of scientific investigations in solar and space physics during the coming decade and beyond. While the accomplishments of the past decades have answered important questions about the physics of the Sun, the interplanetary medium, and the space environments of Earth and other solar system bodies, they have also highlighted other questions, some of which are long-standing and fundamental. This report organizes these questions in terms of five challenges that are expected to be the focus of scientific investigations in solar and space physics during the coming decade and beyond: Challenge 1: Understanding the structure and dynamics of the Sun's interior, the generation of solar magnetic fields, the origin of the solar cycle, the causes of solar activity, and the structure and dynamics of the corona. Challenge 2: Understanding heliospheric structure, the distribution of magnetic fields and matter throughout the solar system, and the interaction of the solar atmosphere with the local interstellar medium. Challenge 3: Understanding the space environments of Earth and other solar system bodies and their dynamical response to external and internal influences. Challenge 4: Understanding the basic physical principles manifest in processes observed in solar and space plasmas. Challenge 5: Developing a near-real-time predictive capability for understanding and quantifying the impact on human activities of dynamical processes at the Sun, in the interplanetary medium, and in Earth's magnetosphere and ionosphere. This report summarizes the state of knowledge about the total heliospheric system, poses key scientific questions for further research, and presents an integrated research strategy, with prioritized initiatives, for the next decade. The recommended strategy embraces both basic research programs and targeted basic research activities that will enhance knowledge and prediction of space weather effects on Earth. The report emphasizes the importance of understanding the Sun, the heliosphere, and planetary magnetospheres and ionospheres as astrophysical objects and as laboratories for the investigation of fundamental plasma physics phenomena.

Moral Development and Behavior: Theory, Research, and Social Issues.

ERIC Educational Resources Information Center

Lickona, Thomas, Ed.

This book contains selections from psychologists, social scientists, and educators on the origins and nature of moral reasoning and behavior. Part one is an introduction and is intended to help the reader organize the wealth of theory and research in the field around eight basic questions confronting a science of morality. Part two sets forth…

A Qualitative Study of Undergraduate International Students' Everyday Experiences with Cross-Cultural Interactions and the Student Adjustment Process

ERIC Educational Resources Information Center

Burkhardt, Joan Wilkinson

2013-01-01

The purpose of this basic qualitative study was to understand how everyday cross-cultural interactions affected the adjustment of undergraduate international students attending a private research university in the northeastern United States. To fulfill this purpose, three research questions were formulated as a foundation for this investigation:…

Microfluidic tools for cell biological research

PubMed Central

Velve-Casquillas, Guilhem; Le Berre, Maël; Piel, Matthieu; Tran, Phong T.

2010-01-01

Summary Microfluidic technology is creating powerful tools for cell biologists to control the complete cellular microenvironment, leading to new questions and new discoveries. We review here the basic concepts and methodologies in designing microfluidic devices, and their diverse cell biological applications. PMID:21152269

34 CFR 668.146 - Criteria for approving tests.

Code of Federal Regulations, 2010 CFR

2010-07-01

... approved under this subpart, a test shall— (1) Assess secondary school level basic verbal and quantitative... verbal and quantitative skills with sufficient numbers of questions to— (i) Adequately represent each... the American Educational Research Association, the American Psychological Association, and the...

Translational research in behavior analysis: historical traditions and imperative for the future.

PubMed

Mace, F Charles; Critchfield, Thomas S

2010-05-01

"Pure basic" science can become detached from the natural world that it is supposed to explain. "Pure applied" work can become detached from fundamental processes that shape the world it is supposed to improve. Neither demands the intellectual support of a broad scholarly community or the material support of society. Translational research can do better by seeking innovation in theory or practice through the synthesis of basic and applied questions, literatures, and methods. Although translational thinking has always occurred in behavior analysis, progress often has been constrained by a functional separation of basic and applied communities. A review of translational traditions in behavior analysis suggests that innovation is most likely when individuals with basic and applied expertise collaborate. Such innovation may have to accelerate for behavior analysis to be taken seriously as a general-purpose science of behavior. We discuss the need for better coordination between the basic and applied sectors, and argue that such coordination compromises neither while benefiting both.

Qualitative research methods for medical educators.

PubMed

Hanson, Janice L; Balmer, Dorene F; Giardino, Angelo P

2011-01-01

This paper provides a primer for qualitative research in medical education. Our aim is to equip readers with a basic understanding of qualitative research and prepare them to judge the goodness of fit between qualitative research and their own research questions. We provide an overview of the reasons for choosing a qualitative research approach and potential benefits of using these methods for systematic investigation. We discuss developing qualitative research questions, grounding research in a philosophical framework, and applying rigorous methods of data collection, sampling, and analysis. We also address methods to establish the trustworthiness of a qualitative study and introduce the reader to ethical concerns that warrant special attention when planning qualitative research. We conclude with a worksheet that readers may use for designing a qualitative study. Medical educators ask many questions that carefully designed qualitative research would address effectively. Careful attention to the design of qualitative studies will help to ensure credible answers that will illuminate many of the issues, challenges, and quandaries that arise while doing the work of medical education. Copyright © 2011 Academic Pediatric Association. All rights reserved.

Structural marsh management research priorities

USGS Publications Warehouse

Cahoon, Donald R.; Groat, Charles G.

1989-01-01

The paper presents a prioritized list of research issues related to structural marsh management developed by a multidisciplinary panel of regulatory agency representatives, landowners, and scientists. More than 75 issues were identified concerning landscape changes, influence on ecological processes (i.e., hydrologic, biologic, and edaphic factors), habitat quality, cumulative impacts, and management approach. These issues were prioritized and organized around six basic questions regulatory personnel must try to answer for each marsh management plan application. The six questions deal with the influence of marsh management on, in order of most immediate need, marsh loss and health, fisheries, wildlife, habitat change, water quality, and cumulative effects.

Basic statistics (the fundamental concepts).

PubMed

Lim, Eric

2014-12-01

An appreciation and understanding of statistics is import to all practising clinicians, not simply researchers. This is because mathematics is the fundamental basis to which we base clinical decisions, usually with reference to the benefit in relation to risk. Unless a clinician has a basic understanding of statistics, he or she will never be in a position to question healthcare management decisions that have been handed down from generation to generation, will not be able to conduct research effectively nor evaluate the validity of published evidence (usually making an assumption that most published work is either all good or all bad). This article provides a brief introduction to basic statistical methods and illustrates its use in common clinical scenarios. In addition, pitfalls of incorrect usage have been highlighted. However, it is not meant to be a substitute for formal training or consultation with a qualified and experienced medical statistician prior to starting any research project.

Investigation of technical problems related to deployment and retrieval of spinning satellites

NASA Technical Reports Server (NTRS)

Kaplan, M. H.

1973-01-01

Results of a three-year research effort on retrieval and deployment problems associated with orbiting payloads are summarized. Answers to several basic questions about rendezvous, docking, and deployment dynamics and controls were obtained. A basic retrieval mission profile was formulated in order to develop relevant technology. A remotely controlled retrieval package was conceived. Special deployment dynamics problems associated with high altitude deployment were investigated, and new knowledge of payload spin reorientation was obtained.

A Slice of Advice.

ERIC Educational Resources Information Center

Glass, Gene V.

1992-01-01

Questions that beginning educational researchers and evaluators will have to answer are discussed concerning: (1) which intellectual tradition to select; (2) the roles of basic and theoretical inquiry; (3) qualitative and quantitative distinctions; (4) the theory-practice relationship; (5) political influences; and (6) the correct emphasis on…

A Qualitative Study of How Cultural Capital Affects Low-Income Undergraduate Students' Decisions to Participate in Highly Ranked Research Institutions in the State of Texas

ERIC Educational Resources Information Center

Walker, Gloria Jean

2014-01-01

The purpose of this basic qualitative study was to understand how cultural capital affected low-income undergraduate students' decisions to participate in higher education at highly ranked research institutions in the State of Texas. To fulfill this purpose, four research questions were formulated as the foundation for this investigation: a/ What…

Library Catalogs: Their Preservation and Maintenance by Photographic and Automated Techniques.

ERIC Educational Resources Information Center

Henderson, James W., Ed.; Rosenthal, Joseph A., Ed.

The report deals with one basic question: what does a large research library do when its catalog shows signs of serious deterioration? The catalog under consideration in this report was the Main Public Catalog of The Research Libraries of The New York Public Library. The catalog has nine million cards, some of which date back to 1857. A 1965…

Teachers' Improvisation of Instructional Materials for Nigerian Home Economics Curriculum Delivery: Challenges and Strategies

ERIC Educational Resources Information Center

Olibie, Eyiuche Ifeoma; Nwabunwanne, Chinyere; Ezenwanne, Dorothy Nkem

2013-01-01

This study was designed to ascertain the challenges of improvising instructional materials by Home Economics teachers at the Upper Basic education level in Nigeria, and as a result identify strategies for enhancing improvisation. The study used survey research design based on two research questions. The sample was four hundred and thirty-one Home…

A Question of Control? Examining the Role of Control Conditions in Experimental Psychopathology using the Example of Cognitive Bias Modification Research.

PubMed

Blackwell, Simon E; Woud, Marcella L; MacLeod, Colin

2017-10-26

While control conditions are vitally important in research, selecting the optimal control condition can be challenging. Problems are likely to arise when the choice of control condition is not tightly guided by the specific question that a given study aims to address. Such problems have become increasingly apparent in experimental psychopathology research investigating the experimental modification of cognitive biases, particularly as the focus of this research has shifted from theoretical questions concerning mechanistic aspects of the association between cognitive bias and emotional vulnerability, to questions that instead concern the clinical efficacy of 'cognitive bias modification' (CBM) procedures. We discuss the kinds of control conditions that have typically been employed in CBM research, illustrating how difficulties can arise when changes in the types of research questions asked are not accompanied by changes in the control conditions employed. Crucially, claims made on the basis of comparing active and control conditions within CBM studies should be restricted to those conclusions allowed by the specific control condition employed. CBM studies aiming to establish clinical utility are likely to require quite different control conditions from CBM studies aiming to illuminate mechanisms. Further, conclusions concerning the clinical utility of CBM interventions cannot necessarily be drawn from studies in which the control condition has been chosen to answer questions concerning mechanisms. Appreciating the need to appropriately alter control conditions in the transition from basic mechanisms-focussed investigations to applied clinical research could greatly facilitate the translational process.

Simplification: A Viewpoint in Outline. Appendix.

ERIC Educational Resources Information Center

Tickoo, Makhan L.

This essay examines language simplification for second language learners as a linguistic and a pedagogic phenomenon, posing questions for further study by considering past research. It discusses linguistic simplification (LS) in relation to the development of artificial languages, such as Esperanto, "pidgin" languages, Basic English,…

Google Search Mastery Basics

ERIC Educational Resources Information Center

Hill, Paul; MacArthur, Stacey; Read, Nick

2014-01-01

Effective Internet search skills are essential with the continually increasing amount of information available on the Web. Extension personnel are required to find information to answer client questions and to conduct research on programs. Unfortunately, many lack the skills necessary to effectively navigate the Internet and locate needed…

78 FR 55299 - Agency Information Collection Activities: Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-10

... to address the effects of question design on survey estimates of public science knowledge and the...: Title: Experimentation with Factual Knowledge of Science Survey Items. OMB Approval Number: 3145-NEW.... 1862) authorizes the National Science foundation to ``initiate and support basic scientific research...

34 CFR 668.146 - Criteria for approving tests.

Code of Federal Regulations, 2011 CFR

2011-07-01

... basic verbal and quantitative skills and general learned abilities; (2) Sample the major content domains of secondary school level verbal and quantitative skills with sufficient numbers of questions to— (i... Educational and Psychological Testing, prepared by a joint committee of the American Educational Research...

34 CFR 668.146 - Criteria for approving tests.

Code of Federal Regulations, 2013 CFR

2013-07-01

... basic verbal and quantitative skills and general learned abilities; (2) Sample the major content domains of secondary school level verbal and quantitative skills with sufficient numbers of questions to— (i... Educational and Psychological Testing, prepared by a joint committee of the American Educational Research...

34 CFR 668.146 - Criteria for approving tests.

Code of Federal Regulations, 2014 CFR

2014-07-01

... basic verbal and quantitative skills and general learned abilities; (2) Sample the major content domains of secondary school level verbal and quantitative skills with sufficient numbers of questions to— (i... Educational and Psychological Testing, prepared by a joint committee of the American Educational Research...

34 CFR 668.146 - Criteria for approving tests.

Code of Federal Regulations, 2012 CFR

2012-07-01

... basic verbal and quantitative skills and general learned abilities; (2) Sample the major content domains of secondary school level verbal and quantitative skills with sufficient numbers of questions to— (i... Educational and Psychological Testing, prepared by a joint committee of the American Educational Research...

Regenerative endodontics and tissue engineering: what the future holds?

PubMed

Goodis, Harold E; Kinaia, Bassam Michael; Kinaia, Atheel M; Chogle, Sami M A

2012-07-01

The work performed by researchers in regenerative endodontics and tissue engineering over the last decades has been superb; however, many questions remain to be answered. The basic biologic mechanisms must be elucidated that will allow the development of dental pulp and dentin in situ. Stress must be placed on the many questions that will lead to the design of effective, safe treatment options and therapies. This article discusses those questions, the answers to which may become the future of regenerative endodontics. The future remains bright, but proper support and patience are required. Copyright © 2012 Elsevier Inc. All rights reserved.

Medical education research for radiologists: a road map for developing a project.

PubMed

Gaetke-Udager, Kara; Yablon, Corrie M

2015-04-01

Medical education research is challenging to do well, but researchers can develop a robust project with knowledge of basic principles. Thoughtful creation of a study question, development of a conceptual framework, and attention to study design are crucial to developing a successful project. A thorough understanding of research methods and elements of survey design is necessary. Projects that result in changes to behavior, clinical practice, and patient outcomes have the most potential for success.

Tendon basic science: Development, repair, regeneration, and healing.

PubMed

Andarawis-Puri, Nelly; Flatow, Evan L; Soslowsky, Louis J

2015-06-01

Tendinopathy and tendon rupture are common and disabling musculoskeletal conditions. Despite the prevalence of these injuries, a limited number of investigators are conducting fundamental, basic science studies focused on understanding processes governing tendinopathies and tendon healing. Development of effective therapeutics is hindered by the lack of fundamental guiding data on the biology of tendon development, signal transduction, mechanotransduction, and basic mechanisms underlying tendon pathogenesis and healing. To propel much needed progress, the New Frontiers in Tendon Research Conference, co-sponsored by NIAMS/NIH, the Orthopaedic Research Society, and the Icahn School of Medicine at Mount Sinai, was held to promote exchange of ideas between tendon researchers and basic science experts from outside the tendon field. Discussed research areas that are underdeveloped and represent major hurdles to the progress of the field will be presented in this review. To address some of these outstanding questions, conference discussions and breakout sessions focused on six topic areas (Cell Biology and Mechanics, Functional Extracellular Matrix, Development, Mechano-biology, Scarless Healing, and Mechanisms of Injury and Repair), which are reviewed in this special issue and briefly presented in this review. Review articles in this special issue summarize the progress in the field and identify essential new research directions. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

A Basic Experiment on the Aerodynamics of Sniffing

NASA Astrophysics Data System (ADS)

Settles, Gary S.; Kester, Douglas A.

1999-11-01

Our previous work (APS/DFD97:Ii1 and 98:FA10) used flow visualization to observe canine olfaction. The results raised some basic questions about the aerodynamics of sniffing, e.g. what flow rate is required, as a function of distance from a scent source, to acquire a detectable scent? Commercial sampler technology does not address such questions. A basic experiment was thus designed to investigate the aerodynamic phenomena and performance of sniffing. A stable thermal layer on a horizontal plane was used as a "scent" source per Reynolds Analogy. The detector was a thermocouple inside a sniffer tube. Flow patterns were observed by schlieren. Results show the importance of sniffer proximity to localize a scent source. A transient scent spike occurs at the sniff onset, followed by signal decline due to source depletion. Sniffing shows extreme sensitivity to disruptive air currents. Unstably-stratified scent sources (thermal plumes) are also considered. These results help us understand evolved sniffing behavior, and they suggest sampler design criteria for electronic-nose devices. (Research supported by DARPA.)

Heuristic and algorithmic processing in English, mathematics, and science education.

PubMed

Sharps, Matthew J; Hess, Adam B; Price-Sharps, Jana L; Teh, Jane

2008-01-01

Many college students experience difficulties in basic academic skills. Recent research suggests that much of this difficulty may lie in heuristic competency--the ability to use and successfully manage general cognitive strategies. In the present study, the authors evaluated this possibility. They compared participants' performance on a practice California Basic Educational Skills Test and on a series of questions in the natural sciences with heuristic and algorithmic performance on a series of mathematics and reading comprehension exercises. Heuristic competency in mathematics was associated with better scores in science and mathematics. Verbal and algorithmic skills were associated with better reading comprehension. These results indicate the importance of including heuristic training in educational contexts and highlight the importance of a relatively domain-specific approach to questions of cognition in higher education.

Unanswered questions in ecology.

PubMed Central

May, R

1999-01-01

This is very much a personal view of what I think are some of the most important unanswered questions in ecology. That is, these are the questions that I expect will be high on the research agenda over the coming century. The list is organized hierarchically, beginning with questions at the level of individual populations, and progressing through interacting populations to entire communities or ecosystems. I will try to guess both at possible advances in basic knowledge and at potential applications. The only thing that is certain about this view of the future is that much of it will surely turn out to be wrong, and many of the most interesting future developments will be quite unforeseen. PMID:10670015

School Discipline Disproportionality: Culturally Competent Interventions for African American Males

ERIC Educational Resources Information Center

Simmons-Reed, Evette A.; Cartledge, Gwendolyn

2014-01-01

Exclusionary policies are practiced widely in schools despite being associated with extremely poor outcomes for culturally and linguistically diverse students, particularly African American males with and without disabilities. This article discusses zero tolerance policies, the related research questioning their basic assumptions, and the negative…

Optically stimulated luminescence (OSL) dosimetry in medicine.

PubMed

Yukihara, E G; McKeever, S W S

2008-10-21

This paper reviews fundamental and practical aspects of optically stimulated luminescence (OSL) dosimetry pertaining to applications in medicine, having particularly in mind new researchers and medical physicists interested in gaining familiarity with the field. A basic phenomenological model for OSL is presented and the key processes affecting the outcome of an OSL measurement are discussed. Practical aspects discussed include stimulation modalities (continuous-wave OSL, pulsed OSL and linear modulation OSL), basic experimental setup, available OSL readers, optical fiber systems and basic properties of available OSL dosimeters. Finally, results from the recent literature on applications of OSL in radiotherapy, radiodiagnostics and heavy charged particle dosimetry are discussed in light of the theoretical and practical framework presented in this review. Open questions and future challenges in OSL dosimetry are highlighted as a guide to the research needed to further advance the field.

Survey research: it's just a few questions, right?

PubMed

Tait, Alan R; Voepel-Lewis, Terri

2015-07-01

While most anesthesiologists and other physician- or nurse-scientists are familiar with traditional descriptive, observational, and interventional study design, survey research has typically remained the preserve of the social scientists. To that end, this article provides a basic overview of the elements of good survey design and offers some rules of thumb to help guide investigators through the survey process. © 2015 John Wiley & Sons Ltd.

The Answer Is in the Question: A Guide for Describing and Investigating the Conceptual Foundations and Statistical Properties of Cognitive Psychometric Models

ERIC Educational Resources Information Center

Rupp, Andre A.

2007-01-01

One of the most revolutionary advances in psychometric research during the last decades has been the systematic development of statistical models that allow for cognitive psychometric research (CPR) to be conducted. Many of the models currently available for such purposes are extensions of basic latent variable models in item response theory…

Thermodynamics and Diffusion Coupling in Alloys—Application-Driven Science

NASA Astrophysics Data System (ADS)

Ågren, John

2012-10-01

As emphasized by Stokes (1997), the common assumption of a linear progression from basic research (science), via applied research, to technological innovations (engineering) should be questioned. In fact, society would gain much by supporting long-term research that stems from practical problems and has usefulness as a key word. Such research may be fundamental, and often, it cannot be distinguished from "basic" research if it were not for its different motivation. The development of the Calphad method and the more recent development of accompanying kinetic approaches for diffusion serve as excellent examples and are the themes of this symposium. The drivers are, e.g., the development of new materials, processes, and lifetime predictions. Many challenges of the utmost practical importance require long-term fundamental research. This presentation will address some of them, e.g., the effect of various ordering phenomena on activation barriers, and the strength and practical importance of correlation effects.

Basic Sciences Fertilizing Clinical Microbiology and Infection Management.

PubMed

Baquero, Fernando

2017-08-15

Basic sciences constitute the most abundant sources of creativity and innovation, as they are based on the passion of knowing. Basic knowledge, in close and fertile contact with medical and public health needs, produces distinct advancements in applied sciences. Basic sciences play the role of stem cells, providing material and semantics to construct differentiated tissues and organisms and enabling specialized functions and applications. However, eventually processes of "practice deconstruction" might reveal basic questions, as in de-differentiation of tissue cells. Basic sciences, microbiology, infectious diseases, and public health constitute an epistemological gradient that should also be an investigational continuum. The coexistence of all these interests and their cross-fertilization should be favored by interdisciplinary, integrative research organizations working simultaneously in the analytical and synthetic dimensions of scientific knowledge. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.

Summary: The natural history and immunobiology of Chlamydia trachomatis genital infection and implications for Chlamydia control.

PubMed

Gottlieb, Sami L; Martin, David H; Xu, Fujie; Byrne, Gerald I; Brunham, Robert C

2010-06-15

In 2008, the US Centers for Disease Control and Prevention held the Chlamydia Immunology and Control Expert Advisory Meeting to foster a dialogue among basic scientists, clinical researchers, and epidemiologists studying genital Chlamydia trachomatis infection. The objectives of the meeting were to determine key questions related to C. trachomatis natural history and immunobiology, with implications for control programs;to review existing data on these key questions; and to delineate research needs to address remaining gaps in knowledge. The 9 articles in this supplement to The Journal of Infectious Diseases describe salient findings presented at the 2008 meeting, and this commentary summarizes and synthesizes these articles and discusses implications for chlamydia control efforts and future research priorities.

Is basic self-disturbance in ultra-high risk for psychosis ('prodromal') patients associated with borderline personality pathology?

PubMed

Nelson, Barnaby; Thompson, Andrew; Chanen, Andrew M; Amminger, Günther Paul; Yung, Alison R

2013-08-01

Research in the phenomenological tradition suggests that the schizophrenia spectrum is characterized by disturbance of the 'basic' self, whereas borderline personality disorder involves disturbance of the 'narrative' self. The current study investigated this proposal in an ultra-high risk for psychosis sample. The sample consisted of 42 ultra-high-risk participants with a mean age of 19.22 years. Basic self-disturbance was measured using the Examination of Anomalous Self-Experience. Borderline personality pathology was measured using the borderline personality disorder items from the structured clinical interview for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition) Axis II Personality Questionnaire. No correlation was found between the measures of basic self-disturbance and borderline personality pathology. The finding is consistent with the proposal that different (although not mutually exclusive) types of self-disturbance characterize the schizophrenia spectrum and borderline personality disorder. Further research should further examine the question of basic self-disturbance in patients with established borderline personality disorder. © 2013 Wiley Publishing Asia Pty Ltd.

Analysis of Prospective Mathematics Teachers’ Basic Teaching Skills (a Study of Mathematics Education Departement Students’ Field Experience Program at STKIP Garut)

NASA Astrophysics Data System (ADS)

Rahayu, D. V.

2017-02-01

This study was intended to figure out basic teaching skills of Mathematics Department Students of STKIP Garut at Field Experience Program in academic year 2014/2015. This study was qualitative research with analysis descriptive technique. Instrument used in this study was observation sheet to measure basic teaching mathematics skills. The result showed that ability of content mastery and explaining skill were in average category. Questioning skill, conducting variations skill and conducting assessment skill were in good category. Managing classroom skill and giving motivation skill were in poor category. Based on the result, it can be concluded that the students’ basic teaching skills weren’t optimal. It is recommended for the collegians to get lesson with appropriate strategy so that they can optimize their basic teaching skills.

Estimated Full Scale IQ in an Adult Heroin Addict Population.

ERIC Educational Resources Information Center

Chastain, Robert L.; And Others

The research concerning intellectual functioning in addict populations has not addressed basic questions concerning why and how intelligence quotients (IQ) might be related to drug addiction. A study was undertaken to estimate intellectual functioning based upon a demographic profile for Wechsler Adult Intelligence Scale-Revised (WAIS-R) Full…

Public's Knowledge of Science and Technology

ERIC Educational Resources Information Center

Pew Research Center, 2013

2013-01-01

The public's knowledge of science and technology varies widely across a range of questions on current topics and basic scientific concepts, according to a new quiz by the Pew Research Center and "Smithsonian" magazine. About eight-in-ten Americans (83%) identify ultraviolet as the type of radiation that sunscreen protects against. Nearly…

Sex Differences in Mental and Behavioral Traits.

ERIC Educational Resources Information Center

Garai, Josef E.; Scheinfeld, Amram

1968-01-01

This review of research conducted on sex differences attempts to answer the following questions: (1) Do the sexes differ in their basic capacities for specific types of mental performance and occupational achievement? (2) If such differences exist, to what extent are they genetically determined? (3) Are sex differences in abilities, interests, and…

Nursing Job Satisfaction: Three Basic Questions.

ERIC Educational Resources Information Center

Black, F. S.; Black, Ruby Lindsey

The theoretical relationships between employee job satisfaction and employee behavior, and the factors that influence job satisfaction among nurses are considered, along with the type of research that should be conducted on this topic. Although major contributions to the theory of human needs have been made by Maslow and by Herzberg, the…

Why AD Graduates Choose Their First Jobs.

ERIC Educational Resources Information Center

Smokvina, Gloria J.; Bratt, Ellen M.

Reasons for the job selections of 64 associate degree nursing graduates were examined in a pilot study at Purdue University. The basic research question was whether nursing graduates initially view "maintenance" or motivational factors as more important. Based on Herzberg's theory of motivation, information is provided on maintenance or hygiene…

The Development of Preschoolers' Living Kinds Concept: A Longitudinal Study

ERIC Educational Resources Information Center

Margett-Jordan, Tessa; Falcon, Rachael G.; Witherington, David C.

2017-01-01

Given limitations in the integrative scope of past research, basic questions about the organization and development of preschoolers' living kinds concept remain open to debate. This study was designed to address past limitations through use of a longitudinal design, extensive stimulus set, and alternate indices of understanding. Thirty-five…

Individual Differences in Dual Task Performance. Final Report.

ERIC Educational Resources Information Center

Lansman, Marcy; Hunt, Earl

This report summarizes the research results and provides a reference. The basic question addressed was, "Is performance on multi-component tasks predicted by performance on the individual components performed separately?" In the first series of experiments, a dual task involving memory and verbal processing components to predict a…

Ethnicity, Denomination and Inequality.

ERIC Educational Resources Information Center

Greeley, Andrew M.

This report relies on a composite sample of 12 National Opinion Research Center surveys (with a total sample of 17,700) to trace out the basic outlines of the achievements of American denominational and ethnic groups. There are three fundamental questions addressed in this analysis: (1) whether there are inequalities of achievement among the…

Measuring School Climate: Questions and Considerations.

ERIC Educational Resources Information Center

Wilson, Bruce L.; McGrail, Janet

School climate is an elusive but powerful concept that has captured the attention of both researchers and practitioners, but choosing an instrument to assess climate can be very complicated. This monograph accordingly discusses four basic issues that should be considered prior to selecting an instrument to measure school climate: purpose, choice…

Children and Adolescents: Should We Teach Them or Let Them Learn?

ERIC Educational Resources Information Center

Rohwer, William D., Jr.

Research to date has provided too few answers for vital educational questions concerning teaching children or letting them learn. A basic problem is that experimentation usually begins by accepting conventional assumptions about schooling, ignoring experiments that would entail disturbing the ordering of current educational priorities.…

Space human factors discipline science plan

NASA Technical Reports Server (NTRS)

1991-01-01

The purpose of this Discipline Science Plan is to provide a conceptual strategy for NASA's Life Sciences Division research and development activities in the comprehensive areas of behavior, performance, and human factors. This document summarizes the current status of the program, outlines available knowledge, establishes goals and objectives, defines critical questions in the subdiscipline areas, and identifies technological priorities. It covers the significant research areas critical to NASA's programmatic requirements for the Extended Duration Orbiter, Space Station Freedom, and Exploration mission science activities. These science activities include ground-based and flight; basic, applied and operational; and animal and human research and development. This document contains a general plan that will be used by both NASA Headquarters program offices and the field centers to review and plan basic, applied, and operational research and development activities, both intramural and extramural, in this area.

The Life Sciences program at the NASA Ames Research Center - An overview

NASA Technical Reports Server (NTRS)

Vernikos-Danellis, Joan; Sharp, Joseph C.

1989-01-01

The research projects planned for the Life Sciences program have a goal of answering basic questions concerning the nature of life itself and its evolution in the universe from basic elements, as well as the search for extraterrestrial intelligence. The program also includes studies of the evolution and development of life on the planet earth, and the global changes occurring today that affect life on the earth. The paper describes the simulation models developed to study the effects of space, the flight projects of the program, and the biomedical program, which currently focuses on the physiological changes in the human body that are associated with space flights and the interactions among these changes.

How to design and write a clinical research protocol in Cosmetic Dermatology*

PubMed Central

Bagatin, Ediléia; Miot, Helio A.

2013-01-01

Cosmetic Dermatology is a growing subspecialty. High-quality basic science studies have been published; however, few double-blind, randomized controlled clinical trials, which are the major instrument for evidence-based medicine, have been conducted in this area. Clinical research is essential for the discovery of new knowledge, improvement of scientific basis, resolution of challenges, and good clinical practice. Some basic principles for a successful researcher include interest, availability, persistence, and honesty. It is essential to learn how to write a protocol research and to know the international and national regulatory rules. A complete clinical trial protocol should include question, background, objectives, methodology (design, variable description, sample size, randomization, inclusion and exclusion criteria, intervention, efficacy and safety measures, and statistical analysis), consent form, clinical research form, and references. Institutional ethical review board approval and financial support disclosure are necessary. Publication of positive or negative results should be an authors' commitment. PMID:23539006

Girls' Access to Education in China: Actors, Cultures and the Windmill of Development Management. CREATE Pathways to Access. Research Monograph No. 39

ERIC Educational Resources Information Center

Wang, Xiaojun Grace

2010-01-01

The world has a mixed record towards achieving EFA [Education for All] and the MDGs [Millennium Development Goals] in relation to the targets on gender equity in basic education. For researchers and practitioners, this raises the question of which factors influence the processes leading to the improvement of access and quality of girls' education…

What Do We Know about Students' Learning and How Do We Know It? Research & Occasional Paper Series: CSHE.7.05

ERIC Educational Resources Information Center

Cross, K. Patricia

2005-01-01

The instruction that we provide, the intellectual climate that we create, and the policy decisions that we make should all start with the question, "But will it improve students' learning?" Basic to any answer is the state of our knowledge about learning. A spate of recent research has resulted in comprehensive and lengthy reviews of surveys of…

Periprosthetic Joint Infections: Clinical and Bench Research

PubMed Central

Legout, Laurence; Senneville, Eric

2013-01-01

Prosthetic joint infection is a devastating complication with high morbidity and substantial cost. The incidence is low but probably underestimated. Despite a significant basic and clinical research in this field, many questions concerning the definition of prosthetic infection as well the diagnosis and the management of these infections remained unanswered. We review the current literature about the new diagnostic methods, the management and the prevention of prosthetic joint infections. PMID:24288493

Favouring more rigour when investigating human eating behaviour is like supporting motherhood and apple pie: A response to Robinson, Bevelander, Field, and Jones (2018).

PubMed

Hetherington, Marion M; Rolls, Barbara J

2018-05-11

In a 1987 paper, addressing questions about factors that influence the initiation, maintenance, and termination of food intake, we wrote, "development of systematic procedures to measure eating behaviour is essential if descriptive and inferential statistics are to be applied to answering such questions, giving them power and replicability" (Hetherington & Rolls, 1987 page 77). Therefore, as longstanding advocates of rigorous procedures in laboratory-based investigations of food intake, we welcome Robinson et al.'s (2018) clear recommendations for laboratory studies. However, this is akin to voting for "motherhood and apple pie", and few would argue against deployment of improved procedures for these studies. What then can we contribute to the debate in order to refine the recommendations made or add to them? Our most important message for researchers is that the central hypothesis or main research question will determine the most appropriate methods for any study. If a laboratory-based study is planned, then there are basic methodological questions that must be answered before proceeding to a final protocol. While such guidelines are needed to ensure basic methodological rigour, these should not be so prescriptive as to inhibit creativity. Here we provide several thoughts on how to advance studies of ingestive behaviour, including the need to apply appropriate controls, encouragement to move beyond convenience samples, and to remember the value of exploratory, observational, and naturalistic studies to complement laboratory-based studies. Copyright © 2018. Published by Elsevier Ltd.

Conducting high-value secondary dataset analysis: an introductory guide and resources.

PubMed

Smith, Alexander K; Ayanian, John Z; Covinsky, Kenneth E; Landon, Bruce E; McCarthy, Ellen P; Wee, Christina C; Steinman, Michael A

2011-08-01

Secondary analyses of large datasets provide a mechanism for researchers to address high impact questions that would otherwise be prohibitively expensive and time-consuming to study. This paper presents a guide to assist investigators interested in conducting secondary data analysis, including advice on the process of successful secondary data analysis as well as a brief summary of high-value datasets and online resources for researchers, including the SGIM dataset compendium ( www.sgim.org/go/datasets ). The same basic research principles that apply to primary data analysis apply to secondary data analysis, including the development of a clear and clinically relevant research question, study sample, appropriate measures, and a thoughtful analytic approach. A real-world case description illustrates key steps: (1) define your research topic and question; (2) select a dataset; (3) get to know your dataset; and (4) structure your analysis and presentation of findings in a way that is clinically meaningful. Secondary dataset analysis is a well-established methodology. Secondary analysis is particularly valuable for junior investigators, who have limited time and resources to demonstrate expertise and productivity.

Lunar interferometric astronomy: Some basic questions

NASA Technical Reports Server (NTRS)

Woolf, Neville

1992-01-01

The author examines some basic questions as to why there should be astronomical facilities on the far side of the moon. The questions are ones of appropriateness, i.e., is this a proper use for human resources, what the real goals are, and are the present concepts the best match for the goals.

Translating basic research into clinical practice or what else do we have to learn about olfactory ensheathing cells?

PubMed

Radtke, Christine; Wewetzer, Konstantin

2009-06-12

Olfactory ensheathing cells (OECs) are Schwann cell-like glial cells of the olfactory system that have been shown to promote axonal regeneration and remyelination in a variety of different lesion paradigms. It is still a matter of debate in how far OECs differ from Schwann cells regarding their regenerative potential and molecular setup. The fact that OECs have been already used for transplantation in humans may imply that the need of the hour is the fine-tuning of clinical application details rather than to cross the bridge between laboratory animal and man. Considering the therapeutic transplantation of OECs, however, the basic question to date is not 'how' to translate but rather 'what' to translate into clinical practice. The aim of the present article is to provide a summary of the current literature and to define the open issues relevant for translating basic research on OECs into clinical practice.

Basic Science Research and the Protection of Human Research Participants

NASA Astrophysics Data System (ADS)

Eiseman, Elisa

2001-03-01

Technological advances in basic biological research have been instrumental in recent biomedical discoveries, such as in the understanding and treatment of cancer, HIV/AIDS, and heart disease. However, many of these advances also raise several new ethical challenges. For example, genetic research may pose no physical risk beyond that of obtaining the initial blood sample, yet it can pose significant psychological and economic risks to research participants, such as stigmatization, discrimination in insurance and employment, invasion of privacy, or breach of confidentiality. These harms may occur even when investigators do not directly interact with the person whose DNA they are studying. Moreover, this type of basic research also raises broader questions, such as what is the definition of a human subject, and what kinds of expertise do Institutional Review Boards (IRBs) need to review the increasingly diverse types of research made possible by these advances in technology. The National Bioethics Advisory Commission (NBAC), a presidentially appointed federal advisory committee, has addressed these and other ethical, scientific and policy issues that arise in basic science research involving human participants. Two of its six reports, in particular, have proposed recommendations in this regard. "Research Involving Human Biological Materials: Ethical and Policy Guidance" addresses the basic research use of human tissues, cells and DNA and the protection of human participants in this type of research. In "Ethical and Policy Issues in the Oversight of Human Research" NBAC proposes a definition of research involving human participants that would apply to all scientific disciplines, including physical, biological, and social sciences, as well as the humanities and related professions, such as business and law. Both of these reports make it clear that the protection of research participants is key to conducting ethically sound research. By ensuring that all participants in research are protected and by educating everyone involved in research with human participants, including the public, investigators, IRB members, institutions, and federal agencies, NBAC’s goal is to develop guidelines by which important basic research can proceed while making sure that the rights and welfare of human research participants are not compromised.

Are we working towards global research priorities for management and conservation of sea turtles?

USGS Publications Warehouse

Rees, A.F.; Alfaro-Shigueto, J.; Barata, P.C.R.; Bjorndal, K.A.; Bolten, A.B.; Bourjea, J.; Broderick, A.C.; Campbell, L.M.; Cardona, L.; Carreras, C.; Casale, P.; Ceriani, S.A.; Dutton, P.H.; Eguchi, T.; Formia, A.; Fuentes, M.M.P.B.; Fuller, W.J.; Girondot, M.; Godfrey, M.H.; Hamann, M.; Hart, Kristen M.; Hays, G.C.; Hochscheid, S.; Kaska, Y.; Jensen, M.P.; Mangel, J.C.; Mortimer, J.A.; Naro-Maciel, E.; Ng, C.K.Y.; Nichols, W.J.; Phillott, A.D.; Reina, R.D.; Revuelta, O.; Schofield, G.; Seminoff, J.A.; Shanker, K.; Tomás, J.; van de Merwe, J.P.; Van Houtan, K.S.; Vander Zanden, H.B.; Wallace, B.P.; Wedemeyer-Strombel, K.R.; Work, Thierry M.; Godley, B.J.

2016-01-01

In 2010, an international group of 35 sea turtle researchers refined an initial list of more than 200 research questions into 20 metaquestions that were considered key for management and conservation of sea turtles. These were classified under 5 categories: reproductive biology, biogeography, population ecology, threats and conservation strategies. To obtain a picture of how research is being focused towards these key questions, we undertook a systematic review of the peer-reviewed literature (2014 and 2015) attributing papers to the original 20 questions. In total, we reviewed 605 articles in full and from these 355 (59%) were judged to substantively address the 20 key questions, with others focusing on basic science and monitoring. Progress to answering the 20 questions was not uniform, and there were biases regarding focal turtle species, geographic scope and publication outlet. Whilst it offers some meaningful indications as to effort, quantifying peer-reviewed literature output is obviously not the only, and possibly not the best, metric for understanding progress towards informing key conservation and management goals. Along with the literature review, an international group based on the original project consortium was assigned to critically summarise recent progress towards answering each of the 20 questions. We found that significant research is being expended towards global priorities for management and conservation of sea turtles. Although highly variable, there has been significant progress in all the key questions identified in 2010. Undertaking this critical review has highlighted that it may be timely to undertake one or more new prioritizing exercises. For this to have maximal benefit we make a range of recommendations for its execution. These include a far greater engagement with social sciences, widening the pool of contributors and focussing the questions, perhaps disaggregating ecology and conservation.

Effect of gravity on vestibular neural development

NASA Technical Reports Server (NTRS)

Ross, M. D.; Tomko, D. L.

1998-01-01

The timing, molecular basis, and morphophysiological and behavioral consequences of the interaction between external environment and the internal genetic pool that shapes the nervous system over a lifetime remain important questions in basic neuroscientific research. Space station offers the opportunity to study this interaction over several life cycles in a variety of organisms. This short review considers past work in altered gravity, particularly on the vestibular system, as the basis for proposing future research on space station, and discusses the equipment necessary to achieve goals. It is stressed that, in keeping with the international investment being made in this research endeavor, both the questions asked and the technologies to be developed should be bold. Advantage must be taken of this unique research environment to expand the frontiers of neuroscience. Copyright 1998 Published by Elsevier Science B.V.

Development of a research ethics knowledge and analytical skills assessment tool.

PubMed

Taylor, Holly A; Kass, Nancy E; Ali, Joseph; Sisson, Stephen; Bertram, Amanda; Bhan, Anant

2012-04-01

The goal of this project was to develop and validate a new tool to evaluate learners' knowledge and skills related to research ethics. A core set of 50 questions from existing computer-based online teaching modules were identified, refined and supplemented to create a set of 74 multiple-choice, true/false and short answer questions. The questions were pilot-tested and item discrimination was calculated for each question. Poorly performing items were eliminated or refined. Two comparable assessment tools were created. These assessment tools were administered as a pre-test and post-test to a cohort of 58 Indian junior health research investigators before and after exposure to a new course on research ethics. Half of the investigators were exposed to the course online, the other half in person. Item discrimination was calculated for each question and Cronbach's α for each assessment tool. A final version of the assessment tool that incorporated the best questions from the pre-/post-test phase was used to assess retention of research ethics knowledge and skills 3 months after course delivery. The final version of the REKASA includes 41 items and had a Cronbach's α of 0.837. The results illustrate, in one sample of learners, the successful, systematic development and use of a knowledge and skills assessment tool in research ethics capable of not only measuring basic knowledge in research ethics and oversight but also assessing learners' ability to apply ethics knowledge to the analytical task of reasoning through research ethics cases, without reliance on essay or discussion-based examination. These promising preliminary findings should be confirmed with additional groups of learners.

Loci of Difficulty in Learning to Program. Technical Report 86-6.

ERIC Educational Resources Information Center

Perkins, David; And Others

To learn more about the specific nature of the teaching and learning problems involved, researchers conducted a clinical study of 20 high school students enrolled a BASIC course. Investigators presented each student with a sequence of eight programming problems, ranging from easy to difficult. They asked questions to track student thinking and…

School Resources and Student Achievement: Data from Rural India

ERIC Educational Resources Information Center

Chudgar, Amita; Chandra, Madhur; Iyengar, Radhika; Shanker, Rishikesh

2015-01-01

In addition to basic infrastructure, what school resources are important to improve learning? This question is hard to answer due to lack of availability of appropriate data. Collaboration between researchers at US universities and a large, well-established educational foundation in India enabled this study to overcome the challenge of data…

Perceptions of Students towards ICT Competencies at the University

ERIC Educational Resources Information Center

Torres-Gastelú, Carlos Arturo; Kiss, Gábor

2016-01-01

The purpose of this study is to identify the perceptions of university students towards their ICT Competencies from two universities, one in Mexico and the other in Hungary. The research type is quantitative and exploratory. The instrument consists of 14 questions related to three types of competencies: Basic, Application and Ethical. The sample…

Designing Evaluations. 2012 Revision. Applied Research and Methods. GAO-12-208G

ERIC Educational Resources Information Center

US Government Accountability Office, 2012

2012-01-01

GAO assists congressional decision makers in their deliberations by furnishing them with analytical information on issues and options. Many diverse methodologies are needed to develop sound and timely answers to the questions the Congress asks. To provide GAO evaluators with basic information about the more commonly used methodologies, GAO's…

Research Findings on Neurolinguistic Programming: Nonsupportive Data or an Untestable Theory?

ERIC Educational Resources Information Center

Sharpley, Christopher F.

1987-01-01

Examines the experimental literature on neurolinguistic programming (NLP). Sharpley (l984) and Einspruch and Forman (l985) concluded that the effectiveness of this therapy was yet to be demonstrated. Presents data from seven recent studies that further question the basic tenets of NLP and their application in counseling situations. (Author/KS)

Physician as Scientist: Preparation, Performance, and Prospects

ERIC Educational Resources Information Center

Castle, William B.

1976-01-01

Greatly modifying the present medical curriculum for the future physician-scientist is not recommended. The value of his having a PhD is questioned and the importance of his working in a hospital-based clinical department is stressed. The author contends that emphasizing the interrelationship between basic and applied research will increase public…

An Odyssey: The Course of Perceptual Development.

ERIC Educational Resources Information Center

Walker-Andrews, Arlene S.

1993-01-01

Reviews "An Odyssey in Learning and Perception" (E. J. Gibson), a volume of collected works that present a first-hand account of many advances in psychology over the past 60 years. A discussion of the two basic questions that capture the essence of Gibson's research, "What is learned" and "What is information" is…

Financial Inequity in Basic Education in Selected OECD Countries

ERIC Educational Resources Information Center

Zhang, Yu; Mizunoya, Suguru; You, You; Tsang, Mun

2011-01-01

This is a study of financial disparities in primary and secondary education in OECD countries that have a relatively large population and a school finance system with decentralized features. These countries include the United States, Britain, Australia, Spain, Canada, and Japan. There are two major research questions: What are the trends in…

Entrepreneurial Training Needs of Illiterate Women in Cross River State, Nigeria

ERIC Educational Resources Information Center

Ingwu, Emmanuel U.; Okey, Stella-Maris A.

2013-01-01

In order to improve on the curriculum and participation rate of adult learners in the current Adult Basic Education (ABE) program in Nigeria, this explorative study investigated the entrepreneurial (or vocational) training needs of illiterate women in Cross River State (CRS). Three research questions were posed to elicit from the participants…

Some Implications of Award Restructure Proposals for Adult Literacy and Basic Education Provision.

ERIC Educational Resources Information Center

Gribble, Helen; Bottomley, John

Award restructure poses questions about appropriate response to the retraining and education needs of workers in Australia who have literacy difficulties. The following actions should be taken: (1) the government should fund a research project that will evaluate workplace efficiency outcomes for employers who have participated in the Workplace…

Quantitative and qualitative methods in medical education research: AMEE Guide No 90: Part II.

PubMed

Tavakol, Mohsen; Sandars, John

2014-10-01

Abstract Medical educators need to understand and conduct medical education research in order to make informed decisions based on the best evidence, rather than rely on their own hunches. The purpose of this Guide is to provide medical educators, especially those who are new to medical education research, with a basic understanding of how quantitative and qualitative methods contribute to the medical education evidence base through their different inquiry approaches and also how to select the most appropriate inquiry approach to answer their research questions.

Quantitative and qualitative methods in medical education research: AMEE Guide No 90: Part I.

PubMed

Tavakol, Mohsen; Sandars, John

2014-09-01

Medical educators need to understand and conduct medical education research in order to make informed decisions based on the best evidence, rather than rely on their own hunches. The purpose of this Guide is to provide medical educators, especially those who are new to medical education research, with a basic understanding of how quantitative and qualitative methods contribute to the medical education evidence base through their different inquiry approaches and also how to select the most appropriate inquiry approach to answer their research questions.

Environmental health discipline science plan

NASA Technical Reports Server (NTRS)

1991-01-01

The purpose of this plan is to provide a conceptual strategy for NASA's Life Sciences Division research and development activities in environmental health. It covers the significant research areas critical to NASA's programmatic requirements for the Extended Duration Orbiter, Space Station Freedom, and exploration mission science activities. These science activities include ground-based and flight; basic, applied, and operational; animal and human subjects; and research and development. This document summarizes the history and current status of the program elements, outlines available knowledge, establishes goals and objectives, identifies scientific priorities, and defines critical questions in the three disciplines: (1) Barophysiology, (2) Toxicology, and (3) Microbiology. This document contains a general plan that will be used by both NASA Headquarters Program Officers and the field centers to review and plan basic, applied, and operational research and development activities, both intramural and extramural, in this area. The document is divided into sections addressing these three disciplines.

Your Genes, Your Choices: Exploring the Issues Raised by Genetic Research

DOE Office of Scientific and Technical Information (OSTI.GOV)

Baker, C.

1999-05-31

Your Genes, Your Choices provides accurate information about the ethical, legal, and social implications of the Human Genome Project and genetic research in an easy-to-read style and format. Each chapter in the book begins with a brief vignette, which introduces an issue within a human story, and raises a question for the reader to think about as the basic science and information are presented in the rest of the chapter.

Ideas, Concepts, Doctrine: Basic Thinking in the United States Air Force, 1961-1984. Volume 2

DTIC Science & Technology

1989-12-01

followed in this new second volume. Dr David MacIsaac, a$sociate director for research, Airpower Research Institute, stimulated much ofthe thinking...us a capability to observe and report the physical evidence of an enemy’s situation . This information is a vital requirement for the conduct of war...asking questions, suggesting alternatives, proposing objectives, stimulating progress .»79 As has been seen, McNamara immediately implemented

Towards shared patient records: an architecture for using routine data for nationwide research.

PubMed

Knaup, Petra; Garde, Sebastian; Merzweiler, Angela; Graf, Norbert; Schilling, Freimut; Weber, Ralf; Haux, Reinhold

2006-01-01

Ubiquitous information is currently one of the most challenging slogans in medical informatics research. An adequate architecture for shared electronic patient records is needed which can use data for multiple purposes and which is extensible for new research questions. We introduce eardap as architecture for using routine data for nationwide clinical research in a multihospital environment. eardap can be characterized as terminology-based. Main advantage of our approach is the extensibility by new items and new research questions. Once the definition of items for a research question is finished, a consistent, corresponding database can be created without any informatics skills. Our experiences in pediatric oncology in Germany have shown the applicability of eardap. The functions of our core system were in routine clinical use in several hospitals. We validated the terminology management system (TMS) and the module generation tool with the basic data set of pediatric oncology. The multiple usability depends mainly on the quality of item planning in the TMS. High quality harmonization will lead to a higher amount of multiply used data. When using eardap, special emphasis is to be placed on interfaces to local hospital information systems and data security issues.

Tobacco counter-advertising: a review of the literature and a conceptual model for understanding effects.

PubMed

Agostinelli, Gina; Grube, Joel W

2003-01-01

The tobacco counter-advertising literature is reviewed as it relates to basic process questions concerning what makes counter-advertisements effective. Limitations in addressing (a) counter-advertisement content and the psychological mediators targeted, (b) counter-advertisement style and the affective reactions targeted, (c) prior smoking experience, and (d) other audience factors are enumerated. A theoretical model based on alcohol advertising research is presented to address those limitations. The model addresses the practical research question of predicting when tobacco counter-advertising will work by examining the independent influence of each of these enumerated factors, as well as how these factors operate in concert, qualifying each other. The model also addresses the process question of explaining how counter-advertising works by identifying affective and cognitive processes as mediators. By understanding the processes that underlie the qualified findings, one can better advise the designers of tobacco counter-advertisements how to be more effective.

Translational physiology: from molecules to public health.

PubMed

Seals, Douglas R

2013-07-15

The term 'translational research' was coined 20 years ago and has become a guiding influence in biomedical research. It refers to a process by which the findings of basic research are extended to the clinical research setting (bench to bedside) and then to clinical practice and eventually health policy (bedside to community). It is a dynamic, multidisciplinary research approach. The concept of translational physiology applies the translational research model to the physiological sciences. It differs from the traditional areas of integrative and clinical physiology by its broad investigative scope of basic research to community health. Translational physiology offers exciting opportunities, but presently is under-developed and -utilized. A key challenge will be to expand physiological research by extending investigations to communities of patients and healthy (or at risk) individuals. This will allow bidirectional physiological investigation throughout the translational continuum: basic research observations can be studied up to the population level, and mechanisms can be assessed by 'reverse translation' in clinical research settings and preclinical models based on initial observations made in populations. Examples of translational physiology questions, experimental approaches, roadblocks and strategies for promotion are discussed. Translational physiology provides a novel framework for physiology programs and an investigational platform for physiologists to study function from molecular events to public health. It holds promise for enhancing the completeness and societal impact of our work, while further solidifying the critical role of physiology in the biomedical research enterprise.

Analysis of Critical Thinking Skills on The Topic of Static Fluid

NASA Astrophysics Data System (ADS)

Puspita, I.; Kaniawati, I.; Suwarma, I. R.

2017-09-01

This study aimed to know the critical thinking skills profil of senior high school students. This research using a descriptive study to analysis student test results of critical thinking skill of 40 students XI grade in one of the senior high school in Bogor District. The method used is survey research with sample determined by purposive sampling technique. The instrument used is test of critical thinking skill by 5 indicators on static fluid topics. Questions consist of 11 set. It is has been developed by researcher and validated by experts. The results showed students critical thinking skills are still low. Is almost every indicator of critical thinking skills only reaches less than 30%. 28% for elementary clarification, 10% for the basic for decisions/basic support, 6% for inference, 6% for advanced clarification, 4% for strategies and tactics.

Can science be a business? Lessons from biotech.

PubMed

Pisano, Gary P

2006-10-01

In 1976, Genentech, the first biotechnology company, was founded by a young venture capitalist and a university professor to exploit recombinant DNA technology. Thirty years and more than 300 billion dollars in investments later, only a handful of biotech firms have matched Genentech's success or even shown a profit. No avalanche of new drugs has hit the market, and the long-awaited breakthrough in R&D productivity has yet to materialize. This disappointing performance raises a question: Can organizations motivated by the need to make profits and please shareholders successfully conduct basic scientific research as a core activity? The question has largely been ignored, despite intense debate over whether business's invasion of basic science-long the domain of universities and nonprofit research institutions- is limiting access to discoveries, thereby slowing advances in science. Biotech has not lived up to its promise, says the author, because its anatomy, which has worked well in other high-tech sectors, can't handle the fundamental challenges facing drug R&D: profound, persistent uncertainty and high risks rooted in the limited knowledge of human biology; the need for the diverse disciplines involved in drug discovery to work together in an integrated fashion; and barriers to learning, including tacit knowledge and murky intellectual property rights, which can slow the pace of scientific advance. A more suitable anatomy would include increased vertical integration; a smaller number of closer, longer collaborations; an emphasis by universities on sharing rather than patenting scientific discoveries; more cross-disciplinary academic research; and more federal and private funding for translational research, which bridges basic and applied science. With such modifications, science can be a business.

An outline of planetary geoscience. [philosophy

NASA Technical Reports Server (NTRS)

1977-01-01

A philosophy for planetary geoscience is presented to aid in addressing a number of major scientific questions; answers to these questions should constitute the basic geoscientific knowledge of the solar system. However, any compilation of major questions or basic knowledge in planetary geoscience involves compromises and somewhat arbitrary boundaries that reflect the prevalent level of understanding at the time.

Analyzing Dyadic Sequence Data—Research Questions and Implied Statistical Models

PubMed Central

Fuchs, Peter; Nussbeck, Fridtjof W.; Meuwly, Nathalie; Bodenmann, Guy

2017-01-01

The analysis of observational data is often seen as a key approach to understanding dynamics in romantic relationships but also in dyadic systems in general. Statistical models for the analysis of dyadic observational data are not commonly known or applied. In this contribution, selected approaches to dyadic sequence data will be presented with a focus on models that can be applied when sample sizes are of medium size (N = 100 couples or less). Each of the statistical models is motivated by an underlying potential research question, the most important model results are presented and linked to the research question. The following research questions and models are compared with respect to their applicability using a hands on approach: (I) Is there an association between a particular behavior by one and the reaction by the other partner? (Pearson Correlation); (II) Does the behavior of one member trigger an immediate reaction by the other? (aggregated logit models; multi-level approach; basic Markov model); (III) Is there an underlying dyadic process, which might account for the observed behavior? (hidden Markov model); and (IV) Are there latent groups of dyads, which might account for observing different reaction patterns? (mixture Markov; optimal matching). Finally, recommendations for researchers to choose among the different models, issues of data handling, and advises to apply the statistical models in empirical research properly are given (e.g., in a new r-package “DySeq”). PMID:28443037

Translational physiology: from molecules to public health

PubMed Central

Seals, Douglas R

2013-01-01

The term ‘translational research’ was coined 20 years ago and has become a guiding influence in biomedical research. It refers to a process by which the findings of basic research are extended to the clinical research setting (bench to bedside) and then to clinical practice and eventually health policy (bedside to community). It is a dynamic, multidisciplinary research approach. The concept of translational physiology applies the translational research model to the physiological sciences. It differs from the traditional areas of integrative and clinical physiology by its broad investigative scope of basic research to community health. Translational physiology offers exciting opportunities, but presently is under-developed and -utilized. A key challenge will be to expand physiological research by extending investigations to communities of patients and healthy (or at risk) individuals. This will allow bidirectional physiological investigation throughout the translational continuum: basic research observations can be studied up to the population level, and mechanisms can be assessed by ‘reverse translation’ in clinical research settings and preclinical models based on initial observations made in populations. Examples of translational physiology questions, experimental approaches, roadblocks and strategies for promotion are discussed. Translational physiology provides a novel framework for physiology programs and an investigational platform for physiologists to study function from molecular events to public health. It holds promise for enhancing the completeness and societal impact of our work, while further solidifying the critical role of physiology in the biomedical research enterprise. PMID:23732641

Periodontal Research: Basics and beyond – Part II (Ethical issues, sampling, outcome measures and bias)

PubMed Central

Avula, Haritha

2013-01-01

A good research beginning refers to formulating a well-defined research question, developing a hypothesis and choosing an appropriate study design. The first part of the review series has discussed these issues in depth and this paper intends to throw light on other issues pertaining to the implementation of research. These include the various ethical norms and standards in human experimentation, the eligibility criteria for the participants, sampling methods and sample size calculation, various outcome measures that need to be defined and the biases that can be introduced in research. PMID:24174747

[The gender debate from the pedagogic perspective].

PubMed

Forster, Johanna

2004-09-01

The question of form and extent of biological and/or cultural influences on female and male behaviour and performance is marking a major focus in present scientific research. Accordingly, a broad spectrum of approaches in research and interpretations of results is available. The recent debate on sex and gender is offering two basic objectives for research in education science: First, the critical review of the data and results on sex specifics presented in respect to the articulation of educational aims, topics and methods. Second, the intensified research focus on the developmental consequences of gender and gender roles for boys and girls, women and men. The pedagogical focus is discussed regarding the following three objectives: 1. developmental conditions in early ontogeny, 2. the question of sex specific differences in cognitive abilities in respect to school performance of adolescents, and 3. teaching knowledge on "sex" and "gender" in schools.

Symbolic Interaction and Applied Social Research: A FOCUS ON TRANSLATIONAL SCIENCE RESEARCH1.

PubMed

Kotarba, Joseph A

2014-08-01

In symbolic interaction, a traditional yet unfortunate and unnecessary distinction has been made between basic and applied research. The argument has been made that basic research is intended to generate new knowledge, whereas applied research is intended to apply knowledge to the solution of practical (social and organizational) problems. I will argue that the distinction between basic and applied research in symbolic interaction is outdated and dysfunctional. The masters of symbolic interactionist thought have left us a proud legacy of shaping their scholarly thinking and inquiry in response to and in light of practical issues of the day (e.g., Znaniecki, and Blumer). Current interactionist work continues this tradition in topical areas such as social justice studies. Applied research, especially in term of evaluation and needs assessment studies, can be designed to serve both basic and applied goals. Symbolic interaction provides three great resources to do this. The first is its orientation to dynamic sensitizing concepts that direct research and ask questions instead of supplying a priori and often impractical answers. The second is its orientation to qualitative methods, and appreciation for the logic of grounded theory. The third is interactionism's overall holistic approach to interfacing with the everyday life world. The primary illustrative case here is the qualitative component of the evaluation of an NIH-funded, translational medical research program. The qualitative component has provided interactionist-inspired insights into translational research, such as examining cultural change in medical research in terms of changes in the form and content of formal and informal discourse among scientists; delineating the impact of significant symbols such as "my lab" on the social organization of science; and appreciating the essence of the self-concept "scientist" on the increasingly bureaucratic and administrative identities of medical researchers. This component has also contributed to the basic social scientific literature on complex organizations and the self.

General Secondary Educators' Experiences in Meeting the Needs of Students with High Functioning Autism Spectrum Disorders

ERIC Educational Resources Information Center

Simien, Ki Eisha

2017-01-01

The purpose of this basic qualitative study was to uncover and understand secondary general school educators' experiences and perspectives in readiness in meeting the needs of high functioning autism spectrum disorder (HFASD) learners within the inclusive teaching environment. The research question served as the foundational premise of the…

The Future of Food Service: A Basis for Planning.

ERIC Educational Resources Information Center

Powers, Thomas F., Ed.; Swinton, John R., Ed.

Designed as a basic reference document, the report has mapped the economic and technological territory of the food service industry, examined the dynamics shaping the industry today, and examined questions in need of further research. It is a volume that might be useful to food service teachers and curriculum planners as well as a volume which…

Experimentation and Research in The Birkman Program of the Austin College Total Institutional Project, 1972-1975.

ERIC Educational Resources Information Center

Austin Coll., Sherman, TX.

The Birkman Method is proprietary, and consists of a battery of psychological instruments, an occupational interest survey, and associated reports, a self-awareness seminar based on the questionnaire, and the supporting computer software and data banks. The questions and occupations are designed to explore basic areas of a person's values,…

Relationships between Readiness Characteristics and Basic Skills Achievement of Rural First Graders.

ERIC Educational Resources Information Center

Liu, Jeanne M.; Brinlee, Patricia S.

The exploratory investigation was guided by four research questions: (1) what are the similarities and differences in the readiness status between rural and urban first graders; (2) what is the relationship between the readiness status and socioeconomic status of rural and urban first graders; (3) what are the similarities and differences in the…

Young Children's Reasoning in Games of Nonsocial and Social Logic: "Tic Tac Toe" and a "Guessing Game".

ERIC Educational Resources Information Center

Fernie, David E.; DeVries, Rheta

This research study tests Selman's (1980) hypothesis that different games pull players toward particular kinds of reasoning through a developmental comparison of children's reasoning in two games, Tic Tac Toe and the Guessing Game. The present study focuses on two basic questions and their educational implications: (1) What differences and…

Where Cognitive Conflict Arises from?: The Structure of Creating Cognitive Conflict

ERIC Educational Resources Information Center

Lee, Gyoungho; Yi, Jinseog

2013-01-01

In this study, our basic contention was that it is essential for researchers to answer the question, "Where does cognitive conflict really arise from?" with more precision than has heretofore been attempted. First, we examined how the term "cognitive conflict" has been treated in the existing literature and try to pinpoint some difficulties,…

Examining the Validity of Self-Reports on Scales Measuring Students' Strategic Processing

ERIC Educational Resources Information Center

Samuelstuen, Marit S.; Braten, Ivar

2007-01-01

Background: Self-report inventories trying to measure strategic processing at a global level have been much used in both basic and applied research. However, the validity of global strategy scores is open to question because such inventories assess strategy perceptions outside the context of specific task performance. Aims: The primary aim was to…

The Information-Seeking Behavior of Intrinsically Motivated Elementary School Children of a Collectivist Culture

ERIC Educational Resources Information Center

Crow, Sherry R.

2015-01-01

This study, conducted in June 2014 in Kampala, Uganda, is a follow-up to a similar study conducted in Colorado Springs, Colorado, in 2008. The basic research question addressed is: "What are the experiences in the lives of upper elementary-aged Ugandan children that foster an intrinsic motivation to seek information?" A secondary…

Picture Books and the Digital World: Educators Making Informed Choices

ERIC Educational Resources Information Center

Yokota, Junko; Teale, William H.

2014-01-01

The book publishing industry in general and picture book materials for children in particular have undergone rapid and profound changes in recent years with the developments in the digital realm. As a result, teachers, school librarians, and literacy researchers have been largely left to their own devices to figure out basic questions related to…

"What's in a Name?": Institutional Critique, Writing Program Archives, and the Problem of Administrator Identity

ERIC Educational Resources Information Center

Lamos, Steve

2009-01-01

When scholars write about their research in writing programs' archives, they often face the ethical question of whether to name the administrators who were involved in documents. The author identifies and provides examples of three basic orientations to this issue, which he calls overt-historical, covert-qualitative, and hybrid-institutional.…

The Teaching of the Code of Ethics and Standard Practices for Texas Educator Preparation Programs

ERIC Educational Resources Information Center

Davenport, Marvin; Thompson, J. Ray; Templeton, Nathan R.

2015-01-01

The purpose of this descriptive quantitative research study was to answer three basic informational questions: (1) To what extent ethics training, as stipulated in Texas Administrative Code Chapter 247, was included in the EPP curriculum; (2) To what extent Texas public universities with approved EPP programs provided faculty opportunities for…

The Characteristics of an Effective Performance Appraisal Interview: A Rules Approach.

ERIC Educational Resources Information Center

Williams, Sheryl L.

A study was conducted to answer the following research questions: (1) to what extent is there consensus in the organizational culture on basic rules for an effective performance; (2) to what extent are there variations in rule consensus for an effective performance appraisal interview among groups within the organization; and (3) to what extent do…

Lighting New Fires: Catholic Schooling in America 25 Years after Vatican II.

ERIC Educational Resources Information Center

Guerra, Michael J.

Two basic questions about Catholic schools are addressed: (1) what is the current status of Catholic schooling in the United States? and (2) what does an analysis of recent trends suggest about the prospects for Catholic schools in the future? Recent research about Catholic schools can be divided into three categories. The first category is…

While it is not deliberate, much of today's biomedical research contains logical and technical flaws, showing a need for corrective action

PubMed Central

He, Yan; Yuan, Chengfu; Chen, Lichan; Liu, Yanjie; Zhou, Haiyan; Xu, Ningzhi; Liao, Dezhong Joshua

2018-01-01

Biomedical research has advanced swiftly in recent decades, largely due to progress in biotechnology. However, this rapid spread of new, and not always-fully understood, technology has also created a lot of false or irreproducible data and artifacts, which sometimes have led to erroneous conclusions. When describing various scientific issues, scientists have developed a habit of saying “on one hand… but on the other hand…”, because discrepant data and conclusions have become omnipresent. One reason for this problematic situation is that we are not always thoughtful enough in study design, and sometimes lack enough philosophical contemplation. Another major reason is that we are too rushed in introducing new technology into our research without assimilating technical details. In this essay, we provide examples in different research realms to justify our points. To help readers test their own weaknesses, we raise questions on technical details of RNA reverse transcription, polymerase chain reactions, western blotting and immunohistochemical staining, as these methods are basic and are the base for other modern biotechnologies. Hopefully, after contemplation and reflection on these questions, readers will agree that we indeed know too little about these basic techniques, especially about the artifacts they may create, and thus many conclusions drawn from the studies using those ever-more-sophisticated techniques may be even more problematic. PMID:29511367

While it is not deliberate, much of today's biomedical research contains logical and technical flaws, showing a need for corrective action.

PubMed

He, Yan; Yuan, Chengfu; Chen, Lichan; Liu, Yanjie; Zhou, Haiyan; Xu, Ningzhi; Liao, Dezhong Joshua

2018-01-01

Biomedical research has advanced swiftly in recent decades, largely due to progress in biotechnology. However, this rapid spread of new, and not always-fully understood, technology has also created a lot of false or irreproducible data and artifacts, which sometimes have led to erroneous conclusions. When describing various scientific issues, scientists have developed a habit of saying "on one hand… but on the other hand…", because discrepant data and conclusions have become omnipresent. One reason for this problematic situation is that we are not always thoughtful enough in study design, and sometimes lack enough philosophical contemplation. Another major reason is that we are too rushed in introducing new technology into our research without assimilating technical details. In this essay, we provide examples in different research realms to justify our points. To help readers test their own weaknesses, we raise questions on technical details of RNA reverse transcription, polymerase chain reactions, western blotting and immunohistochemical staining, as these methods are basic and are the base for other modern biotechnologies. Hopefully, after contemplation and reflection on these questions, readers will agree that we indeed know too little about these basic techniques, especially about the artifacts they may create, and thus many conclusions drawn from the studies using those ever-more-sophisticated techniques may be even more problematic.

Symbolic Interaction and Applied Social Research

PubMed Central

Kotarba, Joseph A.

2014-01-01

In symbolic interaction, a traditional yet unfortunate and unnecessary distinction has been made between basic and applied research. The argument has been made that basic research is intended to generate new knowledge, whereas applied research is intended to apply knowledge to the solution of practical (social and organizational) problems. I will argue that the distinction between basic and applied research in symbolic interaction is outdated and dysfunctional. The masters of symbolic interactionist thought have left us a proud legacy of shaping their scholarly thinking and inquiry in response to and in light of practical issues of the day (e.g., Znaniecki, and Blumer). Current interactionist work continues this tradition in topical areas such as social justice studies. Applied research, especially in term of evaluation and needs assessment studies, can be designed to serve both basic and applied goals. Symbolic interaction provides three great resources to do this. The first is its orientation to dynamic sensitizing concepts that direct research and ask questions instead of supplying a priori and often impractical answers. The second is its orientation to qualitative methods, and appreciation for the logic of grounded theory. The third is interactionism’s overall holistic approach to interfacing with the everyday life world. The primary illustrative case here is the qualitative component of the evaluation of an NIH-funded, translational medical research program. The qualitative component has provided interactionist-inspired insights into translational research, such as examining cultural change in medical research in terms of changes in the form and content of formal and informal discourse among scientists; delineating the impact of significant symbols such as "my lab" on the social organization of science; and appreciating the essence of the self-concept "scientist" on the increasingly bureaucratic and administrative identities of medical researchers. This component has also contributed to the basic social scientific literature on complex organizations and the self. PMID:25221375

Variation of SNOMED CT coding of clinical research concepts among coding experts.

PubMed

Andrews, James E; Richesson, Rachel L; Krischer, Jeffrey

2007-01-01

To compare consistency of coding among professional SNOMED CT coders representing three commercial providers of coding services when coding clinical research concepts with SNOMED CT. A sample of clinical research questions from case report forms (CRFs) generated by the NIH-funded Rare Disease Clinical Research Network (RDCRN) were sent to three coding companies with instructions to code the core concepts using SNOMED CT. The sample consisted of 319 question/answer pairs from 15 separate studies. The companies were asked to select SNOMED CT concepts (in any form, including post-coordinated) that capture the core concept(s) reflected in the question. Also, they were asked to state their level of certainty, as well as how precise they felt their coding was. Basic frequencies were calculated to determine raw level agreement among the companies and other descriptive information. Krippendorff's alpha was used to determine a statistical measure of agreement among the coding companies for several measures (semantic, certainty, and precision). No significant level of agreement among the experts was found. There is little semantic agreement in coding of clinical research data items across coders from 3 professional coding services, even using a very liberal definition of agreement.

Mobility disorders and pain, interrelations that need new research concepts and advanced clinical commitments

PubMed Central

Sajer, Sascha

2017-01-01

This Perspective will discuss topics recently suggested by Prof. Helmut Kern, Vienna, Austria, to advance the research activities of his team, that is: Topic A, 10 years post RISE; Topic B, New research for new solutions on old research questions; Topic C, Working groups on nerve regeneration, training-parameters of seniors in different ages, muscle adaptation; and studies of connective tissue and cartilage. This Perspective summarizes some of the basic concepts and of the evidence-based tools for developing further translational research activities. Clinically relevant results will ask for continuous interests of Basic and Applied Myologists and for the support during the next five to ten years of public and private granting agencies. All together, they will end in protocols, devices and multidisciplinary managements for persons suffering with muscle denervation, neuromuscular-related or non-related pain and for the increasing population of old, older and oldest senior citizens in Europe and beyond. PMID:29299226

Alport syndrome--insights from basic and clinical research.

PubMed

Kruegel, Jenny; Rubel, Diana; Gross, Oliver

2013-03-01

In 1927, Arthur C. Alport first published his description of a triad of symptoms in a family with hereditary congenital haemorrhagic nephritis, deafness and ocular changes. A few years after his death, this group of symptoms was renamed Alport syndrome. To this day, Alport syndrome still inevitably leads to end-stage renal disease and the need for renal replacement therapy, starting in young adulthood. During the past two decades, research into this rare disease has focused on the effects of mutations in collagen type IV and the role of changes in podocytes and the glomerular basement membrane that lead to early kidney fibrosis. Animal models of Alport syndrome also demonstrate the pathogenetic importance of interactions between podocytes and the extracellular matrix. Such models might also help researchers to answer basic questions about podocyte function and the development of fibrosis, and to develop new therapeutic approaches that might be of use in other kidney diseases. In this Review, we discuss the latest basic and clinical research on Alport syndrome, focusing on the roles of podocyte pathology and the extracellular matrix. We also highlight early diagnosis and treatment options for young patients with this disorder.

Variations on the Game of Life

NASA Astrophysics Data System (ADS)

Peper, Ferdinand; Adachi, Susumu; Lee, Jia

The Game of Life is defined in the framework of Cellular Automata with discrete states that are updated synchronously. Though this in itself has proven to be fertile ground for research, it leaves open questions regarding the robustness of the model with respect to variations in updating methods, cell state representations, neighborhood definitions, etc. These questions may become important when the ideal conditions under which the Game of Life is supposed to operate cannot be satisfied, like in physical realizations. This chapter describes three models in which Game of Life-like behavior is obtained, even though some basic tenets are violated.

A research agenda for the European Association for Endoscopic Surgeons (EAES).

PubMed

Francis, Nader; Kazaryan, Airazat M; Pietrabissa, Andrea; Goitein, David; Yiannakopoulou, Eugenia; Agresta, Ferdinando; Khatkov, Igor; Schulze, Svend; Arulampalam, Tan; Tomulescu, Victor; Kim, Young-Woo; Targarona, Eduardo Mª; Zaninotto, Giovanni

2017-05-01

The European Association of Endoscopic Surgeons (EAES) conducted this study aiming to identify the top research questions which are relevant to surgeons in Minimal Access Surgery (MAS). This is in order to promote and link research questions to the current clinical practice in MAS in Europe. Using a systematic methodology, (modified Delphi), the EAES members and leadership teams were surveyed to obtain consensus on the top research priorities in MAS. The responses were categorized and redistributed to the membership to rate the level of importance of each research question. The data were reported as the weighted average score with a scale from 1 (lowest agreement) to 5 (highest agreement). In total, 324 of 2580 (12.5%) of the EAES members and the leaders responded to the survey and contributed to the final consensus. The ranked responses over the 80th percentile identified 39 research priorities with rating ranged from 4.22 to 3.67. The top five highest ranking research priorities in the EAES were centered on improving training in MAS, laparoscopic surgery for benign upper gastrointestinal conditions, integration of novel technology in OR, translational and basic science research in bariatric surgery and investigating the role of MAS in rectal cancer. An EAES research agenda was developed using a systematic methodology and can be used to focus MAS research. This study was commissioned by the European Association for Endoscopic Surgery (EAES).

Moonshot Science-Risks and Benefits.

PubMed

Casadevall, Arturo; Fang, Ferric C

2016-08-30

Ever since the successful Apollo 11 Moon landing in 1969, a "moonshot" has come to signify a bold effort to achieve a seemingly impossible task. The Obama administration recently called for a moonshot to cure cancer, an initiative that has elicited mixed responses from researchers who welcome additional funding but worry about raising expectations. We suggest that a successful moonshot requires a sufficient understanding of the basic science underlying a problem in question so that efforts can be focused on engineering a solution. Current gaps in our basic knowledge of cancer biology make the cancer moonshot a uniquely challenging endeavor. Nevertheless, history has shown that intensive research efforts have frequently yielded conceptual and technological breakthroughs with unanticipated benefits for society. We expect that this effort will be no different. Copyright © 2016 Casadevall and Fang.

Leading Technological Change: A Qualitative Study of High School Leadership in the Implementation of One-To-One Computing

ERIC Educational Resources Information Center

Cohen, Maureen McCallion

2017-01-01

The purpose of this basic qualitative study was to identify and understand the leadership strategies used by Massachusetts high school administrators during the early implementation (first four years) of one-to-one computing. The study was guided by two research questions: (1) How do high school administrators describe their experience leading the…

The Evolution of Vocational Psychology: Questions for a Postmodern Applied Discipline

ERIC Educational Resources Information Center

Krieshok, Thomas S.; Motl, Thomas C.; Rutt, Benjamin T.

2011-01-01

Vocational psychology has a long history of acting as a lens that focuses research in basic sciences on the particular experience of work in people's lives. This article presents several areas on the ascendancy in the broader scientific literature and ask how vocational psychology might apply them to issues of work in people's lives. The authors'…

The Research and Evaluation of Drug-Use Habits of People in North Cyprus

ERIC Educational Resources Information Center

Gürman, Mustafa; Demirdamar, Rümeysa; Basgut, Bilgen

2017-01-01

The purpose of this study is to determine the drug-use habits in North Cyprus and to prepare a demographic study of drug wastage. A total of 450 questionnaires containing 36 questions were handed out in 5 major cities of North Cyprus. Participants' pharmaceutical consumption habits and basic knowledge on rational use were compared with respect to…

Professor Ann De Vaney and a Good Conversation.

ERIC Educational Resources Information Center

Nichols, Randall G.

The author begins this paper by explaining that in examining 10 works by Ann De Vaney his goal is to see what her writing generally reveals about her playing close attention to people-to research subjects, to subjects otherwise addressed in the works, to readers of her works. The author attempts to address each by asking basic questions: (1) What…

Quality Assurance and Evaluation through Brazilian Lenses: An Exploration into the Validity of Umbrella Concepts

ERIC Educational Resources Information Center

Centeno, Vera G.; Kauko, Jaakko; Candido, Helena H. D.

2018-01-01

In our present research we address the question of whether it is valid to apply the Quality Assurance and Evaluation (QAE) umbrella concept, which was formulated to explain new phenomena in European educational governance, to similar developments in Brazilian basic education. This led us to reflect on the possible pitfalls and potential strengths…

Young Children Learn Geometric Concepts Using Logo with a Screen Turtle and a Floor Turtle.

ERIC Educational Resources Information Center

Weaver, Constance L.

This research was designed to investigate several primary questions in comparing the Logo floor turtle to the Logo screen turtle: (1) Do young children gain different geometric concepts from experiences with the floor turtle than they do with the screen turtle? (2) Do young children learn to use the four basic Logo commands more efficiently with…

Implications of Biomedical Technology. Harvard University Program on Technology and Society; Research Review Number One.

ERIC Educational Resources Information Center

Taviss, Irene, Ed.; Koivumaki, Judith, Ed.

A small number of books and articles devoted to the social, political, ethical, and legal implications of the biomedical field and technology have been abstracted for this document. A basic criterion for selection was the focus on questions of overall organization and public policy rather than on more specialized concerns. Topics covered include…

Language Proficiency in Native and Nonnative Speakers: An Agenda for Research and Suggestions for Second-Language Assessment

ERIC Educational Resources Information Center

Hulstijn, Jan H.

2011-01-01

This article addresses the question of what language proficiency (LP) is, both theoretically and empirically. It does so by making a distinction, on one hand, between "basic" and "higher language cognition" and, on the other hand, between "core" and "peripheral components" of LP. The article furthermore critically examines the notion of "level" in…

Learning from Children: Mathematics from a Classroom Perspective. ACER Research Monograph No. 52.

ERIC Educational Resources Information Center

Doig, Brian; Lokan, Jan

This volume has been assembled to show what can be learned about learning from large groups of children's responses to well-constructed assessment questions. The wide range of information gathered through the Basic Skills Testing Program (BSTP) has been divided into chapters that focus either on key aspects of mathematics or the major concerns of…

Challenges and Solutions to Assisting Older Adults in Completing the GED: A Study of What the Experts Say

ERIC Educational Resources Information Center

Brinkley-Etzkorn, Karen E.

2016-01-01

The purpose of this study was to investigate the challenges and solutions encountered by Adult Basic Education (ABE) programs currently serving older adults seeking a GED credential in states where this is the only high school equivalency option available. The following questions guided this research: (1) what are the perceived characteristics and…

Role of basic biological sciences in clinical orthodontics: a case series.

PubMed

Davidovitch, Ze'ev; Krishnan, Vinod

2009-02-01

Orthodontic therapy is based on interaction between mechanics and biology. Basic biologic research aims at developing a better understanding of the mechanism of transformation of mechanical energy into biologic reactions, and exposing the reasons for iatrogenic tissue damage in orthodontics. Previous research has shown that inflammation is a major part of the biologic response to orthodontic forces. In inflammation, signal molecules that originate in remote diseased organs can reach strained paradental tissues and exacerbate the inflammatory process, leading to tissue damage. Our case series includes 3 patients, each having had systemic diseases and malocclusion. One had diabetes mellitus, Hashimoto's thyroiditis, and depression. Concern about the possible effect of these conditions on the well-being of the teeth and their surrounding tissues compelled the orthodontist to choose not to treat this patient. The other 2 patients had allergies, and 1 also had bronchial asthma and bruises. Although these conditions are thought to be risk factors for root resorption, these patients received orthodontic treatment for 2 and 3.5 years, respectively. At the end of treatment, both had excessive root resorption of many teeth. In 1 patient, this damage led to the loss of most maxillary teeth. Basic research should continue to address questions related to the biologic mechanisms of tooth movement on tissue, cellular, and molecular levels. Moreover, this research should continue to identify risk factors that might jeopardize the longevity of treated teeth. Such basic research should promote the development of new tissue-friendly and patient-friendly therapeutic methods.

FOSS Tools for Research Infrastructures - A Success Story?

NASA Astrophysics Data System (ADS)

Stender, V.; Schroeder, M.; Wächter, J.

2015-12-01

Established initiatives and mandated organizations, e.g. the Initiative for Scientific Cyberinfrastructures (NSF, 2007) or the European Strategy Forum on Research Infrastructures (ESFRI, 2008), promote and foster the development of sustainable research infrastructures. The basic idea behind these infrastructures is the provision of services supporting scientists to search, visualize and access data, to collaborate and exchange information, as well as to publish data and other results. Especially the management of research data is gaining more and more importance. In geosciences these developments have to be merged with the enhanced data management approaches of Spatial Data Infrastructures (SDI). The Centre for GeoInformationTechnology (CeGIT) at the GFZ German Research Centre for Geosciences has the objective to establish concepts and standards of SDIs as an integral part of research infrastructure architectures. In different projects, solutions to manage research data for land- and water management or environmental monitoring have been developed based on a framework consisting of Free and Open Source Software (FOSS) components. The framework provides basic components supporting the import and storage of data, discovery and visualization as well as data documentation (metadata). In our contribution, we present our data management solutions developed in three projects, Central Asian Water (CAWa), Sustainable Management of River Oases (SuMaRiO) and Terrestrial Environmental Observatories (TERENO) where FOSS components build the backbone of the data management platform. The multiple use and validation of tools helped to establish a standardized architectural blueprint serving as a contribution to Research Infrastructures. We examine the question of whether FOSS tools are really a sustainable choice and whether the increased efforts of maintenance are justified. Finally it should help to answering the question if the use of FOSS for Research Infrastructures is a success story.

Software engineering from a Langley perspective

NASA Technical Reports Server (NTRS)

Voigt, Susan

1994-01-01

A brief introduction to software engineering is presented. The talk is divided into four sections beginning with the question 'What is software engineering', followed by a brief history of the progression of software engineering at the Langley Research Center in the context of an expanding computing environment. Several basic concepts and terms are introduced, including software development life cycles and maturity levels. Finally, comments are offered on what software engineering means for the Langley Research Center and where to find more information on the subject.

Biological research on a Space Station

NASA Technical Reports Server (NTRS)

Krikorian, A. D.; Johnson, Catherine C.

1990-01-01

A Space Station can provide reliable, long duration access to ug environments for basic and applied biological research. The uniqueness of access to near-weightless environments to probe fundamental questions of significance to gravitational and Space biologists can be exploited from many vantage points. Access to centrifuge facilities that can provide 1 g and hypo-g controls will permit identification of gravity-dependent or primary effects. Understanding secondary effects of the ug environment as well will allow a fuller exploitation of the Space environment.

Proceedings of an AAAS Symposium on January 8, 1980: How Much does the Defense Department Advance Science?

DTIC Science & Technology

1980-09-24

DEFENSE OF FREEDOM 18 Edward Teller DANGERS OF USING SCIENCE FOR THE ARMS BUSINESS IN A CORPORATE STATE 21 George Wald DISCUSSION . 25...many other questions. Does the Don’s basic-research program oversupport research which is oriented to the solution of applied problems? Has DOD...long-range goal of being technologically superior in the world. We would be very short-sighted if our program was directed only to the solution of

Muscle Satellite Cells: Exploring the Basic Biology to Rule Them.

PubMed

Almeida, Camila F; Fernandes, Stephanie A; Ribeiro Junior, Antonio F; Keith Okamoto, Oswaldo; Vainzof, Mariz

2016-01-01

Adult skeletal muscle is a postmitotic tissue with an enormous capacity to regenerate upon injury. This is accomplished by resident stem cells, named satellite cells, which were identified more than 50 years ago. Since their discovery, many researchers have been concentrating efforts to answer questions about their origin and role in muscle development, the way they contribute to muscle regeneration, and their potential to cell-based therapies. Satellite cells are maintained in a quiescent state and upon requirement are activated, proliferating, and fusing with other cells to form or repair myofibers. In addition, they are able to self-renew and replenish the stem pool. Every phase of satellite cell activity is highly regulated and orchestrated by many molecules and signaling pathways; the elucidation of players and mechanisms involved in satellite cell biology is of extreme importance, being the first step to expose the crucial points that could be modulated to extract the optimal response from these cells in therapeutic strategies. Here, we review the basic aspects about satellite cells biology and briefly discuss recent findings about therapeutic attempts, trying to raise questions about how basic biology could provide a solid scaffold to more successful use of these cells in clinics.

Mixed-methods research in pharmacy practice: basics and beyond (part 1).

PubMed

Hadi, Muhammad Abdul; Alldred, David Phillip; Closs, S José; Briggs, Michelle

2013-10-01

This is the first of two papers which explore the use of mixed-methods research in pharmacy practice. In an era of evidence-based medicine and policy, high-quality research evidence is essential for the development of effective pharmacist-led services. Over the past decade, the use of mixed-methods research has become increasingly common in healthcare, although to date its use has been relatively limited in pharmacy practice research. In this article, the basic concepts of mixed-methods research including its definition, typologies and advantages in relation to pharmacy practice research are discussed. Mixed-methods research brings together qualitative and quantitative methodologies within a single study to answer or understand a research problem. There are a number of mixed-methods designs available, but the selection of an appropriate design must always be dictated by the research question. Importantly, mixed-methods research should not be seen as a 'tool' to collect qualitative and quantitative data, rather there should be some degree of 'integration' between the two data sets. If conducted appropriately, mixed-methods research has the potential to generate quality research evidence by combining strengths and overcoming the respective limitations of qualitative and quantitative methodologies. © 2012 Royal Pharmaceutical Society.

Animal models of human anxiety disorders: reappraisal from a developmental psychopathology vantage point.

PubMed

Lampis, Valentina; Maziade, Michel; Battaglia, Marco

2011-05-01

We are witnessing a tremendous expansion of strategies and techniques that derive from basic and preclinical science to study the fine genetic, epigenetic, and proteomic regulation of behavior in the laboratory animal. In this endeavor, animal models of psychiatric illness are becoming the almost exclusive domain of basic researchers, with lesser involvement of clinician researchers in their conceptual design, and transfer into practice of new paradigms. From the side of human behavioral research, the growing interest in gene-environment interplay and the fostering of valid endophenotypes are among the few substantial innovations in the effort of linking common mental disorders to cutting-edge clinical research questions. We argue that it is time for cross-fertilization between these camps. In this article, we a) observe that the "translational divide" can-and should-be crossed by having investigators from both the basic and the clinical sides cowork on simpler, valid "endophenotypes" of neurodevelopmental relevance; b) emphasize the importance of unambiguous physiological readouts, more than behavioral equivalents of human symptoms/syndromes, for animal research; c) indicate and discuss how this could be fostered and implemented in a developmental framework of reference for some common anxiety disorders and ultimately lead to better animal models of human mental disorders.

A high arctic experience of uniting research and monitoring

NASA Astrophysics Data System (ADS)

Schmidt, Niels Martin; Christensen, Torben R.; Roslin, Tomas

2017-07-01

Monitoring is science keeping our thumb on the pulse of the environment to detect any changes of concern for societies. Basic science is the question-driven search for fundamental processes and mechanisms. Given the firm root of monitoring in human interests and needs, basic sciences have often been regarded as scientifically "purer"—particularly within university-based research communities. We argue that the dichotomy between "research" and "monitoring" is an artificial one, and that this artificial split clouds the definition of scientific goals and leads to suboptimal use of resources. We claim that the synergy between the two scientific approaches is well distilled by science conducted under extreme logistic constraints, when scientists are forced to take full advantage of both the data and the infrastructure available. In evidence of this view, we present our experiences from two decades of uniting research and monitoring at the remote research facility Zackenberg in High Arctic Greenland. For this site, we show how the combination of insights from monitoring with the mechanistic understanding obtained from basic research has yielded the most complete understanding of the system—to the benefit of all, and as an example to follow. We therefore urge scientists from across the continuum from monitoring to research to come together, to disregard old division lines, and to work together to expose a comprehensive picture of ecosystem change and its consequences.

Dirt and diarrhoea: formative research in hygiene promotion programmes.

PubMed

Curtis, V; Kanki, B; Cousens, S; Sanou, A; Diallo, I; Mertens, T

1997-06-01

Investment in the promotion of better hygiene for the prevention of diarrhoeal diseases and as a component of water and sanitation programmes is increasing. Before designing programmes capable of sustainably modifying hygiene behaviour in large populations, valid answers to a number of basic questions concerning the site and the intended beneficiaries have to be obtained. Such questions include 'what practices favour the transmission of enteric pathogens?', 'what advantages will be perceived by those who adopt safe practices?' and 'what channels of communication are currently employed by the target population?' A study of hygiene and diarrhoea in Bobo-Dioulasso, Burkina Faso, used a mixture of methods to address such questions. This paper draws on that experience to propose a plan of preliminary research using a variety of techniques which could be implemented over a period of a few months by planners of hygiene promotion programmes. The techniques discussed include structured observation, focus group discussions and behavioural trials. Modest investment in such systematic formative research with clear and limited goals is likely to be repaid many times over in the increased effectiveness of hygiene promotion programmes.

What do international ethics guidelines say in terms of the scope of medical research ethics?

PubMed

Bernabe, Rosemarie D L C; van Thiel, Ghislaine J M W; van Delden, Johannes J M

2016-04-26

In research ethics, the most basic question would always be, "which is an ethical issue, which is not?" Interestingly, depending on which ethics guideline we consult, we may have various answers to this question. Though we already have several international ethics guidelines for biomedical research involving human participants, ironically, we do not have a harmonized document which tells us what these various guidelines say and shows us the areas of consensus (or lack thereof). In this manuscript, we attempted to do just that. We extracted the imperatives from five internationally-known ethics guidelines and took note where the imperatives came from. In doing so, we gathered data on how many guidelines support a specific imperative. We found that there is no consensus on the majority of the imperatives and that in only 8.2% of the imperatives were there at least moderate consensus (i.e., consensus of at least 3 of the 5 ethics guidelines). Of the 12 clusters (Basic Principles; Research Collaboration; Social Value; Scientific Validity; Participant Selection; Favorable Benefit/Risk Ratio; Independent Review; Informed Consent; Respect for Participants; Publication and Registration; Regulatory Sanctions; and Justified Research on the Vulnerable Population), Informed Consent has the highest level of consensus and Research Collaboration and Regulatory Sanctions have the least. There was a lack of consensus in the majority of imperatives from the five internationally-known ethics guidelines. This may be partly explained by the differences among the guidelines in terms of their levels of specification as well as conceptual/ideological differences.

Appraising Quantitative Research in Health Education: Guidelines for Public Health Educators

PubMed Central

Hayes, Sandra C.; Scharalda, Jeanfreau G.; Stetson, Barbara; Jones-Jack, Nkenge H.; Valliere, Matthew; Kirchain, William R.; Fagen, Michael; LeBlanc, Cris

2010-01-01

Many practicing health educators do not feel they possess the skills necessary to critically appraise quantitative research. This publication is designed to help provide practicing health educators with basic tools helpful to facilitate a better understanding of quantitative research. This article describes the major components—title, introduction, methods, analyses, results and discussion sections—of quantitative research. Readers will be introduced to information on the various types of study designs and seven key questions health educators can use to facilitate the appraisal process. Upon reading, health educators will be in a better position to determine whether research studies are well designed and executed. PMID:20400654

2015 Proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine Symposium

PubMed Central

Spitalnik, Steven L.; Triulzi, Darrell; Devine, Dana V.; Dzik, Walter H.; Eder, Anne F.; Gernsheimer, Terry; Josephson, Cassandra D.; Kor, Daryl J.; Luban, Naomi L. C.; Roubinian, Nareg H.; Mondoro, Traci; Welniak, Lisbeth A.; Zou, Shimian; Glynn, Simone

2015-01-01

On March 25-26, 2015, the National Heart, Lung, and Blood Institute sponsored a meeting on the State of the Science in Transfusion Medicine on the NIH campus in Bethesda, MD, which was attended by a diverse group of 330 registrants. The meeting's goal was to identify important research questions that could be answered in the next 5-10 years, and which would have the potential to transform the clinical practice of transfusion medicine. These questions could be addressed by basic, translational, and/or clinical research studies and were focused on four areas: the three “classical” transfusion products (i.e., red blood cells, platelets, and plasma) and blood donor issues. Prior to the meeting, four Working Groups, one for each area, prepared five major questions for discussion along with a list of 5-10 additional questions for consideration. At the meeting itself, all of these questions, and others, were discussed in Keynote lectures, small group breakout sessions, and large group sessions with open discourse involving all meeting attendees. In addition to the final lists of questions, provided herein, the meeting attendees identified multiple overarching, cross-cutting themes that addressed issues common to all four areas; the latter are also provided. It is anticipated that addressing these scientific priorities, with careful attention to the overarching themes, will inform funding priorities developed by the NIH and provide a solid research platform for transforming the future practice of transfusion medicine. PMID:26260861

Interpretation of Genomic Data Questions and Answers

PubMed Central

Simon, Richard

2008-01-01

Using a question and answer format we describe important aspects of using genomic technologies in cancer research. The main challenges are not managing the mass of data, but rather the design, analysis and accurate reporting of studies that result in increased biological knowledge and medical utility. Many analysis issues address the use of expression microarrays but are also applicable to other whole genome assays. Microarray based clinical investigations have generated both unrealistic hyperbole and excessive skepticism. Genomic technologies are tremendously powerful and will play instrumental roles in elucidating the mechanisms of oncogenesis and in devlopingan era of predictive medicine in which treatments are tailored to individual tumors. Achieving these goals involves challenges in re-thinking many paradigms for the conduct of basic and clinical cancer research and for the organization of interdisciplinary collaboration. PMID:18582627

Alternatives to animal experimentation in basic research.

PubMed

Gruber, Franz P; Hartung, Thomas

2004-01-01

In contrast to animal testing required by law to guarantee minimum safety standards for the licensing of drugs and chemicals, there are no regulations in basic research forcing scientists to perform animal tests. By (usually) free choice, questions are posed and hypotheses are examined which, in many cases, can only be answered by means of animal tests. Just as easily, different questions could be asked or different hypotheses could be examined which do not require animal tests. The only criterion for the choice of a topic is its relevance which cannot necessarily be judged in the short-term. Thus, it is up to the individual scientist to judge what is worth studying and therefore worth animal consumption. The educated mind will consider ethical aspects of this choice. However, on the other hand, this decision is largely influenced by questions of efficacy or (in a negative sense) by the obstacles posed to an animal consuming approach. Here, peer review and general attitude will strongly influence the methodology chosen. Availability and awareness of adequate in vitro techniques represent the prerequisites for the use of alternative methods. The least one can do in basic research is to avoid tests which cause severe suffering to animals, as is required in Switzerland and other European countries by binding ethical principles and guidelines. The increasing standard of approval and control procedures has improved the situation over the years. There are many examples of successful alternative methods in basic research. But, the application of such methods is in most cases limited to the laboratories in which they were developed, calling for technology transfer. Exceptions are procedures that are used worldwide, like the production of monoclonal antibodies, which instead of using the ascites mouse can also be performed in vitro with some good will. In these cases, commercialisation of the techniques has aided their spread within the scientific community. Sadly, many methods, even if published in the scientific literature, are little standardised and reproducible. The suggestion is put forward that publicly accessible databases should make available more detailed descriptions of methodologies. Due to limitations in space, many scientific journals cannot publish detailed methodological descriptions. However, nowadays a supplementary central deposit of methods could easily be linked to the respective article. In numerous cases though, there is simply a lack of will to change procedures to methods without animal tests or to pose questions differently in order to avoid the use of animals or to reduce their number or, at least, to reduce stress. In other cases, researchers are simply not aware of the limitations of the animal experiment as such. A thorough review of the validity of critical animal experiments should be carried out and made available publicly. For example, many animal experiments are dramatically "under-powered", i.e. carried out with groups that are too small to allow conclusions to be drawn from the outcome. This stands in marked contrast to in vitro experiments where replicate experiments usually represent no major problem. Since in vitro models are generally more prone to artefacts due to the numerous variables, e.g. of cell culture, the key requirement for their application is their validation and quality control. Guided by the experience from validation studies for alternative methods in toxicology, concepts of a Good Cell Culture Practice (GCCP) are currently being developed which aim to define minimum quality standards for in vitro techniques. This initiative aiming to increase quality must be complemented by a concept to systematically assess the relevance of the tests in order to finally achieve an evidence-based biomedical research. A change in this direction is only possible if those public funds, which were previously assigned predominantly to alternatives to the animal tests required by law, are now channelled increasingly into developing those for basic research. A financial incentive is necessary to change procedures in basic research to animal free procedures. Ethical considerations alone will bring little movement or change. It is unacceptable that, while numbers of animal tests decrease in development and notification of drugs and chemicals, they are increasing in basic research. Due to the central role of publishing scientific results, the key options for control are the respective rules of journals for the acceptance of articles. By demanding certain standards in the instructions for authors, e.g. of quality (GCCP), relevance and in case of animal experiments proof that no alternative is available, pressure could be dramatically increased. It is suggested to hold a consensus conference of journals in the life sciences on this topic.

Dialog on a country path: the qualitative research journey.

PubMed

Sorrell, Jeanne M; Cangelosi, Pamela R; Dinkins, Christine S

2014-03-01

There is little information in the literature describing how students learn qualitative research. This article describes an approach to learning that is based on the pedagogical approach of Dinkins' Socratic-Hermeneutic Shared Inquiry. This approach integrates shared dialog as an essential aspect of learning. The qualitative pedagogy described in this article focused on three questions: What is knowing in qualitative research? How do we come to know qualitative research? What can we do with qualitative research? Students learned the basics of qualitative research within a context that fostered interpretive inquiry. In this way, the course framework mirrored the combination of interviewing, storytelling, and journeying toward understanding that constitute qualitative research. © 2013.

Making Basic Science Studies in Glaucoma More Clinically Relevant: The Need for a Consensus.

PubMed

Toris, Carol B; Gelfman, Claire; Whitlock, Andy; Sponsel, William E; Rowe-Rendleman, Cheryl L

2017-09-01

Glaucoma is a chronic, progressive, and debilitating optic neuropathy that causes retinal damage and visual defects. The pathophysiologic mechanisms of glaucoma remain ill-defined, and there is an indisputable need for contributions from basic science researchers in defining pathways for translational research. However, glaucoma researchers today face significant challenges due to the lack of a map of integrated pathways from bench to bedside and the lack of consensus statements to guide in choosing the right research questions, techniques, and model systems. Here, we present the case for the development of such maps and consensus statements, which are critical for faster development of the most efficacious glaucoma therapy. We underscore that interrogating the preclinical path of both successful and unsuccessful clinical programs is essential to defining future research. One aspect of this is evaluation of available preclinical research tools. To begin this process, we highlight the utility of currently available animal models for glaucoma and emphasize that there is a particular need for models of glaucoma with normal intraocular pressure. In addition, we outline a series of discoveries from cell-based, animal, and translational research that begin to reveal a map of glaucoma from cell biology to physiology to disease pathology. Completion of these maps requires input and consensus from the global glaucoma research community. This article sets the stage by outlining various approaches to such a consensus. Together, these efforts will help accelerate basic science research, leading to discoveries with significant clinical impact for people with glaucoma.

Global justice, capabilities approach and commercial surrogacy in India.

PubMed

Saravanan, Sheela

2015-08-01

Inequalities, ineffective governance, unclear surrogacy regulations and unethical practices make India an ideal environment for global injustice in the process of commercial surrogacy. This article aims to apply the 'capabilities approach' to find possibilities of global justice through human fellowship in the context of commercial surrogacy. I draw primarily on my research findings supplemented by other relevant empirical research and documentary films on surrogacy. The paper reveals inequalities and inadequate basic entitlements among surrogate mothers as a consequence of which they are engaged in unjust contracts. Their limited entitlements also limit their opportunities to engage in enriching goals. It is the role of the state to provide all its citizens with basic entitlements and protect their basic human rights. Individuals in India evading their basic duty also contribute to the existing inequalities. Individual responsibilities of the medical practitioners and the intended parents are in question here as they are more inclined towards self-interest rather than commitment towards human fellowship. At the global level, the injustice in transnational commercial surrogacy practices in developing countries calls for an international declaration of women and child rights in third party reproduction with a normative vision of mutual fellowship and human dignity.

The American Indian Digest.

ERIC Educational Resources Information Center

Russell, George

This guide provides a basic source of historical and contemporary Indian information from an American Indian perspective and includes study questions at the end of each section. The primary function of this guide is to be a quick-study reference handbook. Basic questions essential to understanding current problems and issues of American Indians…

Cross Curriculum: Awakening and Building Prior Knowledge with Primary Sources: See, Think, Wonder

ERIC Educational Resources Information Center

Fontichiaro, Kristin

2010-01-01

The basics of this lesson can be used with students at different levels, helping them to identify what they already know and to build interest in and curiosity for the inquiry work to come. It also guides them to develop questions about things they are curious about and want to know before they begin the research process. In this activity, the…

A Workshop on Family Impact Analysis for the Research Forum of the White House Conference on Families.

ERIC Educational Resources Information Center

Hubbell, Ruth

Family impact analyses are focused on one basic question: What will a given law, policy or practice do to families? There are two major activities in the process of analyzing family impact that has been developed by participants in the Family Impact Seminar: the first involves figuring out exactly how a law, policy, or system under study actually…

Remaking Career and Technical Education for the 21st Century: What Role for High School Programs?

ERIC Educational Resources Information Center

Kazis, Richard

2005-01-01

As part of the broader policy debate on how to reform K-12 education, particularly high schools, basic questions about career and technical education are on the table. "Remaking Career and Technical Education for the 21st Century" begins with a summary of what researchers know--and do not know--about the value of high school…

Properties of Life: Toward a Coherent Understanding of the Organism.

PubMed

Rosslenbroich, Bernd

2016-09-01

The question of specific properties of life compared to nonliving things accompanied biology throughout its history. At times this question generated major controversies with largely diverging opinions. Basically, mechanistic thinkers, who tried to understand organismic functions in terms of nonliving machines, were opposed by those who tried to describe specific properties or even special forces being active within living entities. As this question included the human body, these controversies always have been of special relevance to our self-image and also touched practical issues of medicine. During the second half of the twentieth century, it seemed to be resolved that organisms are explainable basically as physicochemical machines. Especially from the perspective of molecular biology, it seemed to be clear that organisms need to be explained solely by the chemical functions of their component parts, although some resistance to this view never ceased. This research program has been working quite successfully, so that science today knows a lot about the physiological and chemical processes within organisms. However, again new doubts arise questioning whether the mere continuation of this analytical approach will finally generate a fundamental understanding of living entities. At the beginning of the twenty-first century the quest for a new synthesis actually comes from analytical empiricists themselves. The hypothesis of the present paper is that empirical research has been developed far enough today, that it reveals by itself the materials and the prerequisites to understand more of the specific properties of life. Without recourse to mysterious forces, it is possible to generate answers to this age-old question, just using recent, empirically generated knowledge. This view does not contradict the results of reductionistic research, but rather grants them meaning within the context of organismic systems and also may increase their practical usefulness. Although several of these properties have been discussed before, different authors usually concentrated on a single one or some of them. The paper describes ten specific properties of living entities as they can be deduced from contemporary science. The aim is to demonstrate that the results of empirical research show both the necessity as well as the possibility of the development of a new conception of life to build a coherent understanding of organismic functions.

The evolving role of health care organizations in research.

PubMed

Tuttle, W C; Piland, N F; Smith, H L

1988-01-01

Many hospitals and health care organizations are contending with fierce financial and competitive pressures. Consequently, programs that do not make an immediate contribution to master strategy are often overlooked in the strategic management process. Research programs are a case in point. Basic science, clinical, and health services research programs may help to create a comprehensive and fundamentally sound master strategy. This article discusses the evolving role of health care organizations in research relative to strategy formulation. The primary costs and benefits from participating in research programs are examined. An agenda of questions is presented to help health care organizations determine whether they should incorporate health-related research as a key element in their strategy.

Distinguishing treatment from research: a functional approach

PubMed Central

Lewens, T

2006-01-01

The best way to distinguish treatment from research is by their functions. This mode of distinction fits well with the basic ethical work that needs to be carried out. The distinction needs to serve as an ethical flag, highlighting areas in which the goals of doctors and patients are more likely than usual to diverge. The distinction also allows us to illuminate and understand some otherwise puzzling elements of debates on research ethics: it shows the peculiarity of exclusive conceptions of the distinction between research and treatment; it allows us to frame questions about therapeutic obligations in the research context, and it allows us to consider whether there may be research obligations in the therapeutic context. PMID:16816045

Conceptual planning for Space Station life sciences human research project

NASA Technical Reports Server (NTRS)

Primeaux, Gary R.; Miller, Ladonna J.; Michaud, Roger B.

1986-01-01

The Life Sciences Research Facility dedicated laboratory is currently undergoing system definition within the NASA Space Station program. Attention is presently given to the Humam Research Project portion of the Facility, in view of representative experimentation requirement scenarios and with the intention of accommodating the Facility within the Initial Operational Capability configuration of the Space Station. Such basic engineering questions as orbital and ground logistics operations and hardware maintenance/servicing requirements are addressed. Biospherics, calcium homeostasis, endocrinology, exercise physiology, hematology, immunology, muscle physiology, neurosciences, radiation effects, and reproduction and development, are among the fields of inquiry encompassed by the Facility.

Bridging the Gap Between Research and Practice: Implementation Science.

PubMed

Olswang, Lesley B; Prelock, Patricia A

2015-12-01

This article introduces implementation science, which focuses on research methods that promote the systematic application of research findings to practice. The narrative defines implementation science and highlights the importance of moving research along the pipeline from basic science to practice as one way to facilitate evidence-based service delivery. This review identifies challenges in developing and testing interventions in order to achieve widespread adoption in practice settings. A framework for conceptualizing implementation research is provided, including an example to illustrate the application of principles in speech-language pathology. Last, the authors reflect on the status of implementation research in the discipline of communication sciences and disorders. The extant literature highlights the value of implementation science for reducing the gap between research and practice in our discipline. While having unique principles guiding implementation research, many of the challenges and questions are similar to those facing any investigators who are attempting to design valid and reliable studies. This article is intended to invigorate interest in the uniqueness of implementation science among those pursuing both basic and applied research. In this way, it should help ensure the discipline's knowledge base is realized in practice and policy that affects the lives of individuals with communication disorders.

Moving It Along: A study of healthcare professionals' experience with ethics consultations.

PubMed

Crigger, Nancy; Fox, Maria; Rosell, Tarris; Rojjanasrirat, Wilaiporn

2017-05-01

Ethics consultation is the traditional way of resolving challenging ethical questions raised about patient care in the United States. Little research has been published on the resolution process used during ethics consultations and on how this experience affects healthcare professionals who participate in them. The purpose of this qualitative research was to uncover the basic process that occurs in consultation services through study of the perceptions of healthcare professionals. The researchers in this study used a constructivist grounded theory approach that represents how one group of professionals experienced ethics consultations in their hospital in the United States. The results were sufficient to develop an initial theory that has been named after the core concept: Moving It Along. Three process stages emerged from data interpretation: moral questioning, seeing the big picture, and coming together. It is hoped that this initial work stimulates additional research in describing and understanding the complex social process that occurs for healthcare professionals as they address the difficult moral issues that arise in clinical practice.

Evolutionary ethnobiology and cultural evolution: opportunities for research and dialog.

PubMed

Santoro, Flávia Rosa; Nascimento, André Luiz Borba; Soldati, Gustavo Taboada; Ferreira Júnior, Washington Soares; Albuquerque, Ulysses Paulino

2018-01-09

The interest in theoretical frameworks that improve our understanding of social-ecological systems is growing within the field of ethnobiology. Several evolutionary questions may underlie the relationships between people and the natural resources that are investigated in this field. A new branch of research, known as evolutionary ethnobiology (EE), focuses on these questions and has recently been formally conceptualized. The field of cultural evolution (CE) has significantly contributed to the development of this new field, and it has introduced the Darwinian concepts of variation, competition, and heredity to studies that focus on the dynamics of local knowledge. In this article, we introduce CE as an important theoretical framework for evolutionary ethnobiological research. We present the basic concepts and assumptions of CE, along with the adjustments that are necessary for its application in EE. We discuss different ethnobiological studies in the context of this new framework and the new opportunities for research that exist in this area. We also propose a dialog that includes our findings in the context of cultural evolution.

Key Questions Related To Building Collaborative and Inclusive Schools.

ERIC Educational Resources Information Center

Idol, Lorna

1997-01-01

Provides 15 key questions that educators should consider in developing collaborative and inclusive schools. The questions are organized into three categories: general and philosophical questions pertaining to inclusion, questions about the basic mechanics of developing inclusion programs, and questions about the practical implementation of…

Vision Science and Adaptive Optics, The State of the Field

PubMed Central

Marcos, Susana; Werner, John S.; Burns, Stephen A; Merigan, William H.; Artal, Pablo; Atchison, David A.; Hampson, Karen M.; Legras, Richard; Lundstrom, Linda; Yoon, Geungyoung; Carroll, Joseph; Choi, Stacey S.; Doble, Nathan; Dubis, Adam M.; Dubra, Alfredo; Elsner, Ann; Jonnal, Ravi; Miller, Donald T.; Paques, Michel; Smithson, Hannah E.; Young, Laura K.; Zhang, Yuhua; Campbell, Melanie; Hunter, Jennifer; Metha, Andrew; Palczewska, Grazyna; Schallek, Jesse; Sincich, Lawrence C.

2017-01-01

Adaptive optics is a relatively new field, yet it is spreading rapidly and allows new questions to be asked about how the visual system is organized. The editors of this feature issue have posed a series of question to scientists involved in using adaptive optics in vision science. The questions are focused on three main areas. In the first we investigate the use of adaptive optics for psychophysical measurements of visual system function and for improving the optics of the eye. In the second, we look at the applications and impact of adaptive optics on retinal imaging and its promise for basic and applied research. In the third, we explore how adaptive optics is being used to improve our understanding of the neurophysiology of the visual system. PMID:28212982

Commentary on Sommer et al. 'A randomized experiment of the effects of including alternative medicine in the mandatory benefit package of health insurance.

PubMed

Heusser, P

2000-03-01

The study by Sommer et al. recently reported in Complementary Therapies in Medicine has been heavily criticised in Switzerland since its original publication. Its major problems are an inadequate reflection of real practice, an inadequate study design relative to the central research objective, questionable value of the applied instrument and procedure for health assessment, methodological and statistical problems, and failure to consider literature relevant to the topic. For these reasons, this experimental study does not allow an answer to its central questions as to costs and effectiveness of complementary medicine made available within Switzerland's mandatory basic health insurance provisions. We propose more practice-related, non-experimental prospective study designs to realistically answer these questions.

Cloning: can it be good for us? An overview of cloning technology and its moral implications.

PubMed

FitzGerald, K

2001-01-01

Adequate answers to moral questions about cloning require a working knowledge of the science and technology involved, both present and anticipated. This essay presents an overview of the current state of somatic cell nuclear transfer technology (SCNT), the type of cloning that now permits whole organism reproduction from adult DNA. This essay explains the basic science and technology of SCNT and explores its potential uses. Next, this essay notes remaining scientific obstacles and unanswered moral questions that must be resolved before SCNT can be used for human reproduction. Attention is given to aspects related to cloning for therapeutic and research purposes.

Conceptual versus Algorithmic Learning in High School Chemistry: The Case of Basic Quantum Chemical Concepts--Part 2. Students' Common Errors, Misconceptions and Difficulties in Understanding

ERIC Educational Resources Information Center

Papaphotis, Georgios; Tsaparlis, Georgios

2008-01-01

Part 2 of the findings are presented of a quantitative study (n = 125) on basic quantum chemical concepts taught at twelfth grade (age 17-18 years) in Greece. A paper-and-pencil test of fourteen questions was used that were of two kinds: five questions that tested recall of knowledge or application of algorithmic procedures (type-A questions);…

Who's Asking?

ERIC Educational Resources Information Center

Kohn, Alfie

2015-01-01

In this article, Alfie Kohn discusses four questions about questioning--starting with questions that are more basic, and progressing to some that are "deeper and potentially more subversive of traditional schooling." He begins by considering what questions we should ask students, and encourages teachers to keep questions with…

Backward Dependencies and in-Situ wh-Questions as Test Cases on How to Approach Experimental Linguistics Research That Pursues Theoretical Linguistics Questions

PubMed Central

Pablos, Leticia; Doetjes, Jenny; Cheng, Lisa L.-S.

2018-01-01

The empirical study of language is a young field in contemporary linguistics. This being the case, and following a natural development process, the field is currently at a stage where different research methods and experimental approaches are being put into question in terms of their validity. Without pretending to provide an answer with respect to the best way to conduct linguistics related experimental research, in this article we aim at examining the process that researchers follow in the design and implementation of experimental linguistics research with a goal to validate specific theoretical linguistic analyses. First, we discuss the general challenges that experimental work faces in finding a compromise between addressing theoretically relevant questions and being able to implement these questions in a specific controlled experimental paradigm. We discuss the Granularity Mismatch Problem (Poeppel and Embick, 2005) which addresses the challenges that research that is trying to bridge the representations and computations of language and their psycholinguistic/neurolinguistic evidence faces, and the basic assumptions that interdisciplinary research needs to consider due to the different conceptual granularity of the objects under study. To illustrate the practical implications of the points addressed, we compare two approaches to perform linguistic experimental research by reviewing a number of our own studies strongly grounded on theoretically informed questions. First, we show how linguistic phenomena similar at a conceptual level can be tested within the same language using measurement of event-related potentials (ERP) by discussing results from two ERP experiments on the processing of long-distance backward dependencies that involve coreference and negative polarity items respectively in Dutch. Second, we examine how the same linguistic phenomenon can be tested in different languages using reading time measures by discussing the outcome of four self-paced reading experiments on the processing of in-situ wh-questions in Mandarin Chinese and French. Finally, we review the implications that our findings have for the specific theoretical linguistics questions that we originally aimed to address. We conclude with an overview of the general insights that can be gained from the role of structural hierarchy and grammatical constraints in processing and the existing limitations on the generalization of results. PMID:29375417

Backward Dependencies and in-Situ wh-Questions as Test Cases on How to Approach Experimental Linguistics Research That Pursues Theoretical Linguistics Questions.

PubMed

Pablos, Leticia; Doetjes, Jenny; Cheng, Lisa L-S

2017-01-01

The empirical study of language is a young field in contemporary linguistics. This being the case, and following a natural development process, the field is currently at a stage where different research methods and experimental approaches are being put into question in terms of their validity. Without pretending to provide an answer with respect to the best way to conduct linguistics related experimental research, in this article we aim at examining the process that researchers follow in the design and implementation of experimental linguistics research with a goal to validate specific theoretical linguistic analyses. First, we discuss the general challenges that experimental work faces in finding a compromise between addressing theoretically relevant questions and being able to implement these questions in a specific controlled experimental paradigm. We discuss the Granularity Mismatch Problem (Poeppel and Embick, 2005) which addresses the challenges that research that is trying to bridge the representations and computations of language and their psycholinguistic/neurolinguistic evidence faces, and the basic assumptions that interdisciplinary research needs to consider due to the different conceptual granularity of the objects under study. To illustrate the practical implications of the points addressed, we compare two approaches to perform linguistic experimental research by reviewing a number of our own studies strongly grounded on theoretically informed questions. First, we show how linguistic phenomena similar at a conceptual level can be tested within the same language using measurement of event-related potentials (ERP) by discussing results from two ERP experiments on the processing of long-distance backward dependencies that involve coreference and negative polarity items respectively in Dutch. Second, we examine how the same linguistic phenomenon can be tested in different languages using reading time measures by discussing the outcome of four self-paced reading experiments on the processing of in-situ wh -questions in Mandarin Chinese and French. Finally, we review the implications that our findings have for the specific theoretical linguistics questions that we originally aimed to address. We conclude with an overview of the general insights that can be gained from the role of structural hierarchy and grammatical constraints in processing and the existing limitations on the generalization of results.

Intelligent tutoring systems as tools for investigating individual differences in learning

NASA Technical Reports Server (NTRS)

Shute, Valerie J.

1987-01-01

The ultimate goal of this research is to build an improved model-based selection and classification system for the United States Air Force. Researchers are developing innovative approaches to ability testing. The Learning Abilities Measurement Program (LAMP) examines individual differences in learning abilities, seeking answers to the questions of why some people learn more and better than others and whether there are basic cognitive processes applicable across tasks and domains that are predictive of successful performance (or whether there are more complex problem solving behaviors involved).

The NASA Materials Science Research Program - It's New Strategic Goals and Plans

NASA Technical Reports Server (NTRS)

Schlagheck, Ronald A.

2003-01-01

In 2001, the NASA created a separate science enterprise, the Office of Biological and Physical Research (OBPR), to perform strategical and fundamental research bringing together physics, chemistry, biology, and engineering to solve problems needed for future agency mission goals. The Materials Science Program is one of basic research disciplines within this new Enterprise's Division of Physical Sciences Research. The Materials Science Program participates to utilize effective use of International Space Station (ISS) experimental facilities, target new scientific and technology questions, and transfer results for Earth benefits. The program has recently pursued new investigative research in areas necessary to expand NASA knowledge base for exploration of the universe, some of which will need access to the microgravity of space. The program has a wide variety of traditional ground and flight based research related types of basic science related to materials crystallization, fundamental processing, and properties characterization in order to obtain basic understanding of various phenomena effects and relationships to the structures, processing, and properties of materials. A summary of the types and sources for this research is presented and those experiments planned for the space. Areas to help expand the science basis for NASA future missions are described. An overview of the program is given including the scope of the current and future NASA Research Announcements with emphasis on new materials science initiatives. A description of the planned flight experiments to be conducted on the International Space Station program along with the planned facility class Materials Science Research Rack (MSRR) and Microgravity Glovebox (MSG) type investigations.

Thirty-sixth Lauriston S. Taylor Lecture on radiation protection and measurements--from the field to the laboratory and back: the what ifs, wows, and who cares of radiation biology.

PubMed

Brooks, Antone L

2013-11-01

My scientific journey started at the University of Utah chasing fallout. It was on everything, in everything, and was distributed throughout the ecosystem. This resulted in radiation doses to humans and caused me great concern. From this concern I asked the question, "Are there health effects from these radiation doses and levels of radioactive contamination?" I have invested my scientific career trying to address this basic question. While conducting research, I got acquainted with many of the What ifs of radiation biology. The major What if in my research was, "What if we have underestimated the radiation risk for internally-deposited radioactive material?" While conducting research to address this important question, many other What ifs came up related to dose, dose rate, and dose distribution. I also encountered a large number of Wows. One of the first was when I went from conducting environmental fallout studies to research in a controlled laboratory. The activity in fallout was expressed as pCi L⁻¹, whereas it was necessary to inject laboratory animals with μCi g⁻¹ body weight to induce measurable biological changes, chromosome aberrations, and cancer. Wow! That is seven to nine orders of magnitude above the activity levels found in the environment. Other Wows have made it necessary for the field of radiation biology to make important paradigm shifts. For example, one shift involved changing from "hit theory" to total tissue responses as the result of bystander effects. Finally, Who cares? While working at U.S. Department of Energy headquarters and serving on many scientific committees, I found that science does not drive regulatory and funding decisions. Public perception and politics seem to be major driving forces. If scientific data suggested that risk had been underestimated, everyone cared. When science suggested that risk had been overestimated, no one cared. This result-dependent Who cares? was demonstrated as we tried to generate interactions by holding meetings with individuals involved in basic low-dose research, regulators, and the news media. As the scientists presented their "exciting data" that suggested that risk was overestimated, many of the regulators simply said, "We cannot use such data." The newspaper people said, "It is not possible to get such information by my editors." In spite of these difficulties, research results from basic science must be made available and considered by members of the public as well as by those that make regulatory recommendations. Public outreach of the data is critical and must continue to be a future focus to address properly the question of, "Who cares?" My journey in science, like many of yours, has been a mixture of chasing money, beatings, and the joys of unique and interesting research results. Perhaps through our experiences, we can improve research environments, funding, and use of the valuable information that is generated. Scientists that study at all levels of biological organization, from the environment to the laboratory and human epidemiology, must share expertise and data to address the What Ifs, Wows, and Who Cares of radiation biology.

Evaluation of Cross River State Access of Matching Grants for the Implementation of UBE Policies between 2010 and 2014

ERIC Educational Resources Information Center

Enu, Donald Bette; Opoh, Fredrick Awhen; Esu, A. E. O.

2016-01-01

This study focused on the evaluation of access of matching grants for the implementation of UBE policies in upper basic in Cross River State, Nigeria. To achieve the purpose of this study, a research question was posed to guide the study. Data were generated from SUBEB office and downloaded from UBE web site (www.ubec.com). The result was…

From "does it work?" to "what is 'it'?": implications for voodoo, psychotherapy, pop-psychology, regular, and alternative medicine.

PubMed

Mommaerts, Jean-Luc; Devroey, Dirk

2013-01-01

In this article, a "healing method" (HM) is defined as any method intended to improve health through non-somatic means. For many healing methods, especially within the realm of complementary and alternative medicine (CAM), there is mounting debate over the question "Does it work?" Indeed, this seems to be the primary question for most stakeholders. Yet in light of the well-documented effects of nonspecific factors, particularly empathy and placebo (EP), we contend that the basic question is: "What is 'it'?" Without answering this question, scientific progress is impossible, and research costs will spiral upwards without producing tangible results. Furthermore, it is impossible to characterize the potential side effects of healing methods without a full understanding of the underlying mechanisms through which they act. It is generally acknowledged that many healing methods are sociohistorical artifacts, based on underlying theoretical models that are divorced from established science. There is a need for healing method research that is accommodating of such methods' fluid nature while being congruent with accepted scientific practices. "It works" is no longer an adequate justification for any healing method, as "it" often turns out to be a combination of nonspecific factors.

Stem Cell Niche, the Microenvironment and Immunological Crosstalk

PubMed Central

Sujata, Law; Chaudhuri, S

2008-01-01

The concept of stem cells, their physiological existence, the intricate anatomical localization, the known and the unknown functions, and their exclusive utility for the purpose of regenerative medicine, are all now encompassed within an emergent question, ‘how compatible these cells are immunologically?' Indeed, the medical aspects of stem cells are dependent on a large number of queries based on the basic properties of the cells. It has greatly been emphasized to probe into the basic research on stem cells before any successful therapeutic attempts are made. One of the intricate aspects of the adult stem cells is its immunological behavior in relation to the microenvironmental associates, the stromal cells in the presence of a suitable target. PMID:18445340

Stem cell niche, the microenvironment and immunological crosstalk.

PubMed

Sujata, Law; Chaudhuri, S

2008-04-01

The concept of stem cells, their physiological existence, the intricate anatomical localization, the known and the unknown functions, and their exclusive utility for the purpose of regenerative medicine, are all now encompassed within an emergent question, 'how compatible these cells are immunologically?' Indeed, the medical aspects of stem cells are dependent on a large number of queries based on the basic properties of the cells. It has greatly been emphasized to probe into the basic research on stem cells before any successful therapeutic attempts are made. One of the intricate aspects of the adult stem cells is its immunological behavior in relation to the microenvironmental associates, the stromal cells in the presence of a suitable target.

[Memorandum IV: Theoretical and Normative Grounding of Health Services Research].

PubMed

Baumann, W; Farin, E; Menzel-Begemann, A; Meyer, T

2016-05-01

With Memoranda and other initiatives, the German Network for Health Service Research [Deutsches Netzwerk Versorgungsforschung e.V. (DNVF)] is fostering the methodological quality of care research studies for years. Compared to the standards of empirical research, questions concerning the role and function of theories, theoretical approaches and scientific principles have not been taken up on its own. Therefore, the DNVF e.V. has set up a working group in 2013, which was commissioned to prepare a memorandum on "theories in health care research". This now presented memorandum will primarily challenge scholars in health care services research to pay more attention to questions concerning the theoretical arsenal and the background assumptions in the research process. The foundation in the philosophy of science, the reference to normative principles and the theory-bases of the research process are addressed. Moreover, the memorandum will call on to advance the theorizing in health services research and to strengthen not empirical approaches, research on basic principles or studies with regard to normative sciences and to incorporate these relevant disciplines in health services research. Research structures and funding of health services research needs more open space for theoretical reflection and for self-observation of their own, multidisciplinary research processes. © Georg Thieme Verlag KG Stuttgart · New York.

Ludwig von Bertalanffy's organismic view on the theory of evolution.

PubMed

Drack, Manfred

2015-03-01

Ludwig von Bertalanffy was a key figure in the advancement of theoretical biology. His early considerations already led him to recognize the necessity of considering the organism as a system, as an organization of parts and processes. He termed the resulting research program organismic biology, which he extended to all basic questions of biology and almost all areas of biology, hence also to the theory of evolution. This article begins by outlining the rather unknown (because often written in German) research of Bertalanffy in the field of theoretical biology. The basics of the organismic approach are then described. This is followed by Bertalanffy's considerations on the theory of evolution, in which he used methods from theoretical biology and then introduced his own, organismic, view on evolution, leading to the demand for finding laws of evolution. Finally, his view on the concept of homology is presented. © 2015 Wiley Periodicals, Inc.

A general approach-avoidance hypothesis of oxytocin: accounting for social and non-social effects of oxytocin.

PubMed

Harari-Dahan, Osnat; Bernstein, Amit

2014-11-01

We critically reexamine extant theory and empirical study of Oxytocin. We question whether OT is, in fact, a "social neuropeptide" as argued in dominant theories of OT. We critically review human and animal research on the social and non-social effects of Oxytocin, including behavioral, psychophysiological, neurobiological, and neuroimaging studies. We find that extant (social) theories of Oxytocin do not account for well-documented non-social effects of Oxytocin. Furthermore, we find a range of evidence that social and non-social effects of Oxytocin may be mediated by core approach-avoidance motivational processes. We propose a General Approach-avoidance Hypothesis of Oxytocin (GAAO). We argue that the GAAO may provide a parsimonious account of established social and non-social effects of Oxytocin. We thus re-conceptualize the basic function(s) and mechanism(s) of action of Oxytocin. Finally, we highlight implications of the GAAO for basic and clinical research in humans

Vision science and adaptive optics, the state of the field.

PubMed

Marcos, Susana; Werner, John S; Burns, Stephen A; Merigan, William H; Artal, Pablo; Atchison, David A; Hampson, Karen M; Legras, Richard; Lundstrom, Linda; Yoon, Geungyoung; Carroll, Joseph; Choi, Stacey S; Doble, Nathan; Dubis, Adam M; Dubra, Alfredo; Elsner, Ann; Jonnal, Ravi; Miller, Donald T; Paques, Michel; Smithson, Hannah E; Young, Laura K; Zhang, Yuhua; Campbell, Melanie; Hunter, Jennifer; Metha, Andrew; Palczewska, Grazyna; Schallek, Jesse; Sincich, Lawrence C

2017-03-01

Adaptive optics is a relatively new field, yet it is spreading rapidly and allows new questions to be asked about how the visual system is organized. The editors of this feature issue have posed a series of question to scientists involved in using adaptive optics in vision science. The questions are focused on three main areas. In the first we investigate the use of adaptive optics for psychophysical measurements of visual system function and for improving the optics of the eye. In the second, we look at the applications and impact of adaptive optics on retinal imaging and its promise for basic and applied research. In the third, we explore how adaptive optics is being used to improve our understanding of the neurophysiology of the visual system. Copyright © 2017 Elsevier Ltd. All rights reserved.

Measuring social science concepts in pharmacy education research: From definition to item analysis of self-report instruments.

PubMed

Cor, M Ken

Interpreting results from quantitative research can be difficult when measures of concepts are constructed poorly, something that can limit measurement validity. Social science steps for defining concepts, guidelines for limiting construct-irrelevant variance when writing self-report questions, and techniques for conducting basic item analysis are reviewed to inform the design of instruments to measure social science concepts in pharmacy education research. Based on a review of the literature, four main recommendations emerge: These include: (1) employ a systematic process of conceptualization to derive nominal definitions; (2) write exact and detailed operational definitions for each concept, (3) when creating self-report questionnaires, write statements and select scales to avoid introducing construct-irrelevant variance (CIV); and (4) use basic item analysis results to inform instrument revision. Employing recommendations that emerge from this review will strengthen arguments to support measurement validity which in turn will support the defensibility of study finding interpretations. An example from pharmacy education research is used to contextualize the concepts introduced. Copyright © 2017 Elsevier Inc. All rights reserved.

Activities of the Space Studies Board

NASA Technical Reports Server (NTRS)

1994-01-01

This 1993 annual report of the Space Studies Board of the National research Council (NRC) describes the activities of the Board during a year filled with questions and change in the nation's civil space program. The accounts contained in this report briefly describe the activities of the Board and its committees and sketch out major space research issues. Two major reports are summarized, and the full text of three letter reports is included. Items considered include: (1) robotic missions to explore the Earth, the solar system, and the far reaches of the universe; (2) instability in the human flight program; (3) the redesign of the International Space Station; and (4) federal funding of research in all fields, especially basic research.

Aura Science and Validation

NASA Technical Reports Server (NTRS)

Hilsenrath, E.; Schoeberl, M.; Douglass, A.; Anderson, J.; Bhartia, P. K. (Technical Monitor)

2002-01-01

The EOS-Aura Mission is designed to answer three basic questions concerning the Earth's atmosphere: 1) Is ozone recovering as predicted, 2) is air quality getting worse, and 3) how is climate changing? Aura's four instruments work synergistically and are dedicated to answering these questions. These questions relate to NASA Earth Science Enterprise's overall strategic questions, which seek to understand the consequences of climate change for human civilization and determine if these changes can be predicted. NASA supports an ongoing research and analysis program, which is conducted independently and in support of satellite missions. The research program conducts several on-going field campaigns employing aircraft, balloons, and ground based systems. These campaigns have focused on exploring processes in the tropics, high latitudes, and continental outflow to explain the chemistry and transport in the troposphere and stratosphere and how these regions interact. NASA is now studying how the Aura mission and requirements of the research and analysis program might be merged to achieve its strategic goals related to global atmospheric chemistry changes. In addition, NASA field campaign resources will be folded into Aura's validation requirements. Aura validation requires correlative measurements throughout the troposphere and stratosphere under a range of observing and geophysical conditions. Because of the recent launches of Envisat and other smaller international chemistry satellites, the NASA program plans to collaborate with European space agencies in developing a series of campaigns that will provide continuity between those satellites missions and Aura.

Carrier rockets

NASA Astrophysics Data System (ADS)

Aleksandrov, V. A.; Vladimirov, V. V.; Dmitriev, R. D.; Osipov, S. O.

This book takes into consideration domestic and foreign developments related to launch vehicles. General information concerning launch vehicle systems is presented, taking into account details of rocket structure, basic design considerations, and a number of specific Soviet and American launch vehicles. The basic theory of reaction propulsion is discussed, giving attention to physical foundations, the various types of forces acting on a rocket in flight, basic parameters characterizing rocket motion, the effectiveness of various approaches to obtain the desired velocity, and rocket propellants. Basic questions concerning the classification of launch vehicles are considered along with construction and design considerations, aspects of vehicle control, reliability, construction technology, and details of structural design. Attention is also given to details of rocket motor design, the basic systems of the carrier rocket, and questions of carrier rocket development.

Designing a grounded theory study: some practicalities.

PubMed

McCallin, Antoinette M

2003-01-01

Grounded theory is an interpretative research methodology frequently used by social science researchers seeking to discover the underlying social processes shaping interaction. The methodology is useful to create knowledge about the behavioural patterns of a group. The aim of this paper was to discuss some practical issues that the prospective grounded theory researcher planning a small-scale project may consider. Discussion focuses on the basic premises, choosing a version of grounded theory, the research problem, the purpose of study, the research question and the place of the literature in a study. The specific skills required of the grounded theory researcher are considered and some cautions are exercised. The paper may assist student researchers in a critical care setting and may be of interest to their supervisors and experienced. grounded theory researchers.

Choosing Open Source ERP Systems: What Reasons Are There For Doing So?

NASA Astrophysics Data System (ADS)

Johansson, Björn; Sudzina, Frantisek

Enterprise resource planning (ERP) systems attract a high attention and open source software does it as well. The question is then if, and if so, when do open source ERP systems take off. The paper describes the status of open source ERP systems. Based on literature review of ERP system selection criteria based on Web of Science articles, it discusses reported reasons for choosing open source or proprietary ERP systems. Last but not least, the article presents some conclusions that could act as input for future research. The paper aims at building up a foundation for the basic question: What are the reasons for an organization to adopt open source ERP systems.

The future of ageing.

PubMed

Hayflick, L

2000-11-09

Advances in our knowledge of age-associated diseases have far outpaced advances in our understanding of the fundamental ageing processes that underlie the vulnerability to these pathologies. If we are to increase human life expectancy beyond the fifteen-year limit that would result if today's leading causes of death were resolved, more attention must be paid to basic research on ageing. Determination of longevity must be distinguished from ageing to take us from the common question of why we age to a more revealing question that is rarely posed: why do we live as long as we do? But if the ability to intervene in ageing ever becomes a reality, it will be rife with unintended and undesirable consequences.

Big Science and the Large Hadron Collider

NASA Astrophysics Data System (ADS)

Giudice, Gian Francesco

2012-03-01

The Large Hadron Collider (LHC), the particle accelerator operating at CERN, is probably the most complex and ambitious scientific project ever accomplished by humanity. The sheer size of the enterprise, in terms of financial and human resources, naturally raises the question whether society should support such costly basic-research programs. I address this question by first reviewing the process that led to the emergence of Big Science and the role of large projects in the development of science and technology. I then compare the methodologies of Small and Big Science, emphasizing their mutual linkage. Finally, after examining the cost of Big Science projects, I highlight several general aspects of their beneficial implications for society.

The Pashtun Behavior Economy: An Analysis of Decision Making in Tribal Society

DTIC Science & Technology

2011-06-01

SUB-SAHARAN AFRICA ) from the NAVAL POSTGRADUATE SCHOOL June 2011 Author: Jeremy W. Holton Approved by: Thomas H. Johnson...push up the market values of their own opium production farms .6 A. MAJOR RESEARCH QUESTION The anecdotes above reflect some of the most basic...Yet another proof has been given of the wave of fanaticism which is sweeping along the North -West frontier of India. Malakand was the scene last

Dynamics and control of detumbling a disabled spacecraft during rescue operations

NASA Technical Reports Server (NTRS)

Kaplan, M. H.

1973-01-01

Results of a two-year research effort on dynamics and control of detumbling a disabled spacecraft during rescue operations are summarized. Answers to several basic questions about associated techniques and hardware requirements were obtained. Specifically, efforts have included development of operational procedures, conceptual design of remotely controlled modules, feasibility of internal moving mass for stabilization, and optimal techniques for minimum-time detumbling. Results have been documented in several reports and publications.

Unifying theory for terrestrial research infrastructures

NASA Astrophysics Data System (ADS)

Mirtl, Michael

2016-04-01

The presentation will elaborate on basic steps needed for building a common theoretical base between Research Infrastructures focusing on terrestrial ecosystems. This theoretical base is needed for developing a better cooperation and integrating in the near future. An overview of different theories will be given and ways to a unifying approach explored. In the second step more practical implications of a theory-guided integration will be developed alongside the following guiding questions: • How do the existing and planned European environmental RIs map on a possible unifying theory on terrestrial ecosystems (covered structures and functions, scale; overlaps and gaps) • Can a unifying theory improve the consistent definition of RÍs scientific scope and focal science questions? • How could a division of tasks between RIs be organized in order to minimize parallel efforts? • Where concretely do existing and planned European environmental RIs need to interact to respond to overarching questions (top down component)? • What practical fora and mechanisms (across RIs) would be needed to bridge the gap between PI driven (bottom up) efforts and the centralistic RI design and operations?

[Peculiarity of consumer preference shaping in pharmaceutical market in azerbaijan].

PubMed

Mansurova, L

2011-01-01

Pharmaceutical market researches in terms of consumer behavior are topical in current social-economical conditions. Thereby the goal of these researches is studying of particular properties of consumer behavior on the drug market and identifying of factors affect on its formation. The method of questioning was used. The questionnaire has been completed from the point of view of possibilities and interests of common consumer. One part of questions was concerned to demographical and personal characteristics of customers. For the analysis of consumer behavior have been used parameters such as frequency of visits to definite pharmacy, attraction of pharmacy, types of purchases. The survey had been determined the basic factors of pharmacy visitors' consumer behavior. According to the consumers opinion the main criteria of choice of pharmacy were professional knowledge and experience of pharmacy's workers. Some of economical factors, such as affordability and etc. have been analyzed.

Improved knowledge gain and retention for third-year medical students during surgical journal club using basic science review: A pilot study.

PubMed

Williams, Austin D; Mann, Barry D

2017-02-01

As they enter the clinical years, medical students face large adjustments in the acquisition of medical knowledge. We hypothesized that basic science review related to the topic of journal club papers would increase the educational benefit for third-year medical students. Students were randomized either to participation in a review session about basic science related to the journal club paper, or to no review. After one day, and after three months, students were given a 10-question quiz encompassing the basic science and the clinical implications of the paper. Twenty-six of 50 students were randomized to basic science review. These students scored better on both sections of the quiz one day after journal club, but only on basic science questions after three months. Students who participated in basic science review had better knowledge gain and retention. Educational activities building upon foundational knowledge improves learning on clinical rotations. Copyright © 2016 Elsevier Inc. All rights reserved.

Numeracy skills of undergraduate entry level nurse, midwife and pharmacy students.

PubMed

Arkell, Sharon; Rutter, Paul M

2012-07-01

The ability of healthcare professionals to perform basic numeracy and therefore dose calculations competently is without question. Research has primarily focused on nurses, and to a lesser extent doctors, ability to perform this function with findings highlighting poor aptitude. Studies involving pharmacists are few but findings are more positive than other healthcare staff. To determine first year nursing, midwifery and pharmacy students ability to perform basic numeracy calculations. All new undergraduate entrants to nursing, midwifery and pharmacy sat a formative numeracy test within the first two weeks of their first year of study. Test results showed that pharmacy students significantly outperformed midwifery and nursing students on all questions. In turn midwifery students outperformed nurses, although this did not achieve significance. When looking at each cohorts general attitude towards mathematics, pharmacy students were more positive and confident compared to midwifery and nursing students. Pharmacy students expressed greater levels of enjoyment and confidence in performing mathematics and correspondingly showed the greatest proficiency. In contrast nurse, and to a lesser extent midwifery students showed poor performance and low confidence levels. Copyright © 2012 Elsevier Ltd. All rights reserved.

Rethinking intractable conflict: the perspective of dynamical systems.

PubMed

Vallacher, Robin R; Coleman, Peter T; Nowak, Andrzej; Bui-Wrzosinska, Lan

2010-01-01

Intractable conflicts are demoralizing. Beyond destabilizing the families, communities, or international regions in which they occur, they tend to perpetuate the very conditions of misery and hate that contributed to them in the first place. Although the common factors and processes associated with intractable conflicts have been identified through research, they represent an embarrassment of riches for theory construction. Thus, the current task in this area is integrating these diverse factors into an account that provides a coherent perspective yet allows for prediction and a basis for conflict resolution in specific conflict settings. We suggest that the perspective of dynamical systems provides such an account. This article outlines the key concepts and hypotheses associated with this approach. It is organized around a set of basic questions concerning intractable conflict for which the dynamical perspective offers fresh insight and testable propositions. The questions and answers are intended to provide readers with basic concepts and principles of complexity and dynamical systems that are useful for rethinking the nature of intractable conflict and the means by which such conflict can be transformed. Copyright 2010 APA, all rights reserved.

Bridging basic and clinical science with policy studies: The Partners with Transdisciplinary Tobacco Use Research Centers experience.

PubMed

Kobus, Kimberly; Mermelstein, Robin

2009-05-01

The Partners with Transdisciplinary Tobacco Use Research Centers (TTURCs) initiative was a transdisciplinary team-building program, funded by the Robert Wood Johnson Foundation, to expand the policy research capacity of the TTURCs. EXPANSION INTO POLICY RESEARCh: Policy research activities at the TTURCs fell into four broad domains: (a) health services research, (b) examination of the business case for cessation treatment and funding, (c) collaborative teams with key stakeholders, and (d) direct assessment of smoking-related policies. Examples of each domain are presented. Goals of the initiative included efforts to foster collaborative, transdisciplinary research, to bring new investigators into the field, to develop programs of policy research, to answer next-step translational questions, and to enhance awareness of policy relevance. Success at meeting each of these goals is discussed. We offer recommendations for incorporating programs of policy research into full-spectrum transdisciplinary research initiatives, including the roles of research teams, senior researchers, infrastructure, stakeholders, and communications activities. The TTURC Partners initiative represented a first-generation effort to fill the gap between scientific discovery and research translation through expansion into policy studies. While all aspects of the effort were not equally successful, the effort demonstrated that it is possible to develop successful collaborations that extend more basic and applied research into studies that examine their policy and practice implications.

To stress or not to stress: a question of models.

PubMed

Gray, J Megan; Chaouloff, Francis; Hill, Matthew N

2015-01-05

Stress research is a rapidly evolving field that encompasses numerous disciplines ranging from neuroscience to metabolism. With many new researchers migrating into the field, navigating the hows and whys of specific research questions can sometimes be enigmatic given the availability of so many models in the stress field. Additionally, as with every field, there are many seemingly minor experimental details that can have dramatic influences on data interpretation, although many of these are unknown to those not familiar with the field. The aim of this overview is to provide some suggestions and points to guide researchers moving into the stress field and highlight relevant methodological points that they should consider when choosing a model for stress and deciding how to structure a study. We briefly provide a primer on the basics of endpoint measurements in the stress field, factors to consider when choosing a model for acute stress, the difference between repeated and chronic stress, and importantly, influencing variables that modulate endpoints of analysis in stress work. Copyright © 2015 John Wiley & Sons, Inc.

Computer literacy for life sciences: helping the digital-era biology undergraduates face today's research.

PubMed

Smolinski, Tomasz G

2010-01-01

Computer literacy plays a critical role in today's life sciences research. Without the ability to use computers to efficiently manipulate and analyze large amounts of data resulting from biological experiments and simulations, many of the pressing questions in the life sciences could not be answered. Today's undergraduates, despite the ubiquity of computers in their lives, seem to be largely unfamiliar with how computers are being used to pursue and answer such questions. This article describes an innovative undergraduate-level course, titled Computer Literacy for Life Sciences, that aims to teach students the basics of a computerized scientific research pursuit. The purpose of the course is for students to develop a hands-on working experience in using standard computer software tools as well as computer techniques and methodologies used in life sciences research. This paper provides a detailed description of the didactical tools and assessment methods used in and outside of the classroom as well as a discussion of the lessons learned during the first installment of the course taught at Emory University in fall semester 2009.

The Application of Intensive Longitudinal Methods to Investigate Change: Stimulating the Field of Applied Family Research.

PubMed

Bamberger, Katharine T

2016-03-01

The use of intensive longitudinal methods (ILM)-rapid in situ assessment at micro timescales-can be overlaid on RCTs and other study designs in applied family research. Particularly, when done as part of a multiple timescale design-in bursts over macro timescales-ILM can advance the study of the mechanisms and effects of family interventions and processes of family change. ILM confers measurement benefits in accurately assessing momentary and variable experiences and captures fine-grained dynamic pictures of time-ordered processes. Thus, ILM allows opportunities to investigate new research questions about intervention effects on within-subject (i.e., within-person, within-family) variability (i.e., dynamic constructs) and about the time-ordered change process that interventions induce in families and family members beginning with the first intervention session. This paper discusses the need and rationale for applying ILM to family intervention evaluation, new research questions that can be addressed with ILM, example research using ILM in the related fields of basic family research and the evaluation of individual-based interventions. Finally, the paper touches on practical challenges and considerations associated with ILM and points readers to resources for the application of ILM.

How to conduct a high-quality original study on a diagnostic research topic.

PubMed

Yao, Xiaomei; Vella, Emily

2017-09-01

As health research methodologists and journal reviewers, we noticed that the methodological rigor of many publications on diagnostic or prognostic topics in the medical literature could be improved. We present a concise and clear series of reviews to help clinicians and health researchers to master the basic key components of how to conduct a high-quality original study or systematic review on a diagnostic or prognostic research topic from a methodological perspective. This is the first review of the series, which focuses on how to conduct a high-quality diagnostic study. We are introducing four aspects: clarifying the objectives; generating an appropriate research question; planning the study design; and reporting and analyzing data. This review highlights that diagnostic test accuracy outcomes are surrogates for patient outcomes, a diagnostic test has three roles, the "PIRO" components should be included in a diagnostic research question, a new study should be registered, multiple index tests can be compared in one study, and prevalence affects test accuracy outcomes. This review also emphasizes reporting any thresholds, calculating sample size, and performing a two-by-three table to calculate diagnostic outcomes. Copyright © 2017 Elsevier Ltd. All rights reserved.

The Application of Intensive Longitudinal Methods to Investigate Change: Stimulating the Field of Applied Family Research

PubMed Central

Bamberger, Katharine T.

2015-01-01

The use of intensive longitudinal methods (ILM)—rapid in situ assessment at micro timescales—can be overlaid on RCTs and other study designs in applied family research. Especially when done as part of a multiple timescale design—in bursts over macro timescales, ILM can advance the study of the mechanisms and effects of family interventions and processes of family change. ILM confers measurement benefits in accurately assessing momentary and variable experiences and captures fine-grained dynamic pictures of time-ordered processes. Thus, ILM allows opportunities to investigate new research questions about intervention effects on within-subject (i.e., within-person, within-family) variability (i.e., dynamic constructs) and about the time-ordered change process that interventions induce in families and family members beginning with the first intervention session. This paper discusses the need and rationale for applying ILM to intervention evaluation, new research questions that can be addressed with ILM, example research using ILM in the related fields of basic family research and the evaluation of individual-based (rather than family-based) interventions. Finally, the paper touches on practical challenges and considerations associated with ILM and points readers to resources for the application of ILM. PMID:26541560

Towards the XML schema measurement based on mapping between XML and OO domain

NASA Astrophysics Data System (ADS)

Rakić, Gordana; Budimac, Zoran; Heričko, Marjan; Pušnik, Maja

2017-07-01

Measuring quality of IT solutions is a priority in software engineering. Although numerous metrics for measuring object-oriented code already exist, measuring quality of UML models or XML Schemas is still developing. One of the research questions in the overall research leaded by ideas described in this paper is whether we can apply already defined object-oriented design metrics on XML schemas based on predefined mappings. In this paper, basic ideas for mentioned mapping are presented. This mapping is prerequisite for setting the future approach to XML schema quality measuring with object-oriented metrics.

Moral instability: the upsides for nursing practice.

PubMed

McCarthy, Joan

2010-04-01

This article briefly outlines some of the key problems with the way in which the moral realm has traditionally been understood and analysed. I propose two alternative views of what is morally interesting and applicable to nursing practice and I indicate that instability has its upsides. I begin with a moral tale - a 'Good Samaritan' story - which raises fairly usual questions about the nature of morality but also the more philosophically fundamental question about the relationship between subjectivity and moral agency. I then consider this relationship from the perspectives of two twentieth century philosophers: Emmanuel Levinas and Michel Foucault. Levinas' basic point is that the experience of ethical subjectivity is made possible through others: the demand to respond to the existence of others is the basic social structure that precedes individual freedom. If Levinas posits intersubjectivity as a fundamental or primitive feature of the moral realm, Foucault poses an even more basic question: how have moral subjects and relations of obligation been constituted? The aim of ethical inquiry, for Foucault, is to describe the network of discourses, institutions, relations, and practices through which certain kinds of subjects are constituted and constitute themselves, e.g. as a kind of person who can act morally. Finally, I consider some recent research in philosophy of nursing which illustrates how Levinasian and/or Foucauldian perspectives can deepen understanding of nurses' moral practices, specifically, the work of Norwegian public health nurses, Canadian pediatric nurses, and Irish midwives. I suggest that in spite of the instability of morality in general and the particular ethical challenges that face nurses, there are grounds for hope and possible strategies for living in unstable times.

Membrane Fluidity Changes, A Basic Mechanism of Interaction of Gravity with Cells?

NASA Astrophysics Data System (ADS)

Kohn, Florian; Hauslage, Jens; Hanke, Wolfgang

2017-10-01

All life on earth has been established under conditions of stable gravity of 1g. Nevertheless, in numerous experiments the direct gravity dependence of biological processes has been shown on all levels of organization, from single molecules to humans. According to the underlying mechanisms a variety of questions, especially about gravity sensation of single cells without specialized organelles or structures for gravity sensing is being still open. Biological cell membranes are complex structures containing mainly lipids and proteins. Functional aspects of such membranes are usually attributed to membrane integral proteins. This is also correct for the gravity dependence of cells and organisms which is well accepted since long for a wide range of biological systems. However, it is as well established that parameters of the lipid matrix are directly modifying the function of proteins. Thus, the question must be asked, whether, and how far plain lipid membranes are affected by gravity directly. In principle it can be said that up to recently no real basic mechanism for gravity perception in single cells has been presented or verified. However, it now has been shown that as a basic membrane parameter, membrane fluidity, is significantly dependent on gravity. This finding might deliver a real basic mechanism for gravity perception of living organisms on all scales. In this review we summarize older and more recent results to demonstrate that the finding of membrane fluidity being gravity dependent is consistent with a variety of published laboratory experiments. We additionally point out to the consequences of these recent results for research in the field life science under space condition.

Internet delivered question and answer column for patients with schizophrenia.

PubMed

Maijala, Riikka; Anttila, Minna; Koivunen, Marita; Pitkänen, Anneli; Kuosmanen, Lauri; Välimäki, Maritta

2015-01-01

The purpose of this study was to describe the use of an Internet delivered question and answer column among patients with schizophrenia. The column was developed for research purposes. The study sample consisted of patients (N = 100) admitted to acute inpatient psychiatric care in two hospital districts. Descriptive data were collected from the column to which a nurse replied within 3 days and analysed using qualitative content analysis. The column had four to five questions weekly. The most common age of users was 18-24 years, and the gender distribution was almost equal. Column use was heaviest among students (44%) and least among unemployed people (19%). Out of 85 questions or comments sent to the column, 25 (29%) were related to program training and the remaining 60 (71%) were related to medication (31%), illness and tests (25%), other questions or comments (9%), daily life and coping with it (4%), and places to receive treatment (2%). An Internet delivered question and answer column can be included in the care of patients with schizophrenia. However, it requires a new type of basic and additional education in the field of mental health care in order for nurses to be able to provide nursing via the Internet forum.

Descriptive Statistics: Reporting the Answers to the 5 Basic Questions of Who, What, Why, When, Where, and a Sixth, So What?

PubMed

Vetter, Thomas R

2017-11-01

Descriptive statistics are specific methods basically used to calculate, describe, and summarize collected research data in a logical, meaningful, and efficient way. Descriptive statistics are reported numerically in the manuscript text and/or in its tables, or graphically in its figures. This basic statistical tutorial discusses a series of fundamental concepts about descriptive statistics and their reporting. The mean, median, and mode are 3 measures of the center or central tendency of a set of data. In addition to a measure of its central tendency (mean, median, or mode), another important characteristic of a research data set is its variability or dispersion (ie, spread). In simplest terms, variability is how much the individual recorded scores or observed values differ from one another. The range, standard deviation, and interquartile range are 3 measures of variability or dispersion. The standard deviation is typically reported for a mean, and the interquartile range for a median. Testing for statistical significance, along with calculating the observed treatment effect (or the strength of the association between an exposure and an outcome), and generating a corresponding confidence interval are 3 tools commonly used by researchers (and their collaborating biostatistician or epidemiologist) to validly make inferences and more generalized conclusions from their collected data and descriptive statistics. A number of journals, including Anesthesia & Analgesia, strongly encourage or require the reporting of pertinent confidence intervals. A confidence interval can be calculated for virtually any variable or outcome measure in an experimental, quasi-experimental, or observational research study design. Generally speaking, in a clinical trial, the confidence interval is the range of values within which the true treatment effect in the population likely resides. In an observational study, the confidence interval is the range of values within which the true strength of the association between the exposure and the outcome (eg, the risk ratio or odds ratio) in the population likely resides. There are many possible ways to graphically display or illustrate different types of data. While there is often latitude as to the choice of format, ultimately, the simplest and most comprehensible format is preferred. Common examples include a histogram, bar chart, line chart or line graph, pie chart, scatterplot, and box-and-whisker plot. Valid and reliable descriptive statistics can answer basic yet important questions about a research data set, namely: "Who, What, Why, When, Where, How, How Much?"

Planning for Parent Choice: A Guide to Parent Surveys and Parent Involvement in Planning for Parent and Professional Choice in the Public Schools. [Parent Choice and the Public Schools: Volume 2].

ERIC Educational Resources Information Center

Clinchy, Evans

This guide, second in a series of four volumes, offers a method of surveying parents' attitudes about choosing schools for their children and provides a survey instrument used over a period of 5 years in four Massachusetts urban school districts. Section 1 introduces the basic research questions pursued in the survey. Section 2, "The Parent…

Attitudinal survey component of the study Quantity, quality, and support for research in the U.S. Fish and Wildlife Service: An organizational assessment: Report of methods and frequencies

USGS Publications Warehouse

Neilson, Jennifer R.; Lamb, Berton Lee; Swann, Earlene M.; Ratz, Joan; Ponds, Phadrea D.; Liverca, Joyce

2005-01-01

The findings presented in this report represent the basic results derived from the attitude assessment survey conducted in the last quarter of 2004. The findings set forth in this report are the frequency distributions for each question in the survey instrument for all respondents. The only statistics provided are descriptive in character - namely, means and associated standard deviations.

Is mandatory research ethics reviewing ethical?

PubMed

Dyck, Murray; Allen, Gary

2013-08-01

Review boards responsible for vetting the ethical conduct of research have been criticised for their costliness, unreliability and inappropriate standards when evaluating some non-medical research, but the basic value of mandatory ethical review has not been questioned. When the standards that review boards use to evaluate research proposals are applied to review board practices, it is clear that review boards do not respect researchers or each other, lack merit and integrity, are not just and are not beneficent. The few benefits of mandatory ethical review come at a much greater, but mainly hidden, social cost. It is time that responsibility for the ethical conduct of research is clearly transferred to researchers, except possibly in that small proportion of cases where prospective research participants may be so intrinsically vulnerable that their well-being may need to be overseen.

Panel on Graduate Education in Science

NASA Astrophysics Data System (ADS)

Strom, S.; Edwards, S.; Gallagher, J. S.; Levy, E.; York, D.; van Horn, H.; Wyckoff, S.

1995-12-01

As a result of the shifting emphasis for public investment in basic research and higher education, opportunities for new PhDs to follow traditional academic research careers are expected to decrease. Given these realities, it is both essential and timely to re-examine the role of graduate schools in serving our discipline, our students, and the society which supports us. Central to the discussion are the questions: (1) What should be the goals and content of an astronomy graduate education in view of (a) the discipline's need to continue a tradition of carrying out world class research, and (b) our nation's need for imaginative, scientifically capable and adaptable young people, both in the technical workforce and as teachers in the nation's schools? (2) Should we consider changing our admissions policies, graduate curricula, funding patterns or academic culture to meet the needs of (a) our discipline, and (b) our nation? The panelists will share their current perspectives on these very challenging questions. A follow-up open discussion on these issues will be held on Tuesday evening. A detailed outline of the questions regarding the goals of graduate education in astronomy formulated by the AAS Education Policy Board may be found through the Education link on the AAS World Wide Web homepage.

Ethical issues related to epilepsy care in the developing world.

PubMed

Tan, Chong-Tin; Avanzini, Giuliano

2009-05-01

There are three major issues of ethical concern related to epilepsy care in the developing world. First, is it ethical for a developing country to channel its limited resources from direct epilepsy care to research? The main considerations in addressing this question are the particular research questions to be addressed and whether such research will bring direct benefits to the local community. Second, in a country with limited resources, when does ignoring the high treatment gap become an ethical issue? This question is of particular concern when the community has enough resources to afford treatment for its poor, yet is not providing such care because of gross wastage and misallocation of the national resources. Third, do countries with plentiful resources have an ethical responsibility to help relieve the high epilepsy treatment gap of poor countries? Indeed, we believe that reasonable health care is a basic human right, and that human rights transcend national boundaries. Although health care is usually the responsibility of the nation-state, many modern states in the developing world are arbitrary creations of colonization. There is often a long process from the establishment of a political-legal state to a mature functional nation. During the long process of nation building, help from neighboring countries is often required.

Alternative management and funding options for aeronautics programs, Task 1

NASA Technical Reports Server (NTRS)

1975-01-01

Research and technology will be at lower program levels with basic military research for aviation decreasing as fewer aircraft programs are initiated and the present new aircraft programs move into the prototype and production status. The key question is can industry take on the management and financing role and meet the criteria and characteristics considered essential for a viable research and technology program. The criteria for evaluating alternative approaches include an examination of the nature of the product to be provided, responsiveness to changing needs, efficiency in terms of costs, ability to provide leadership, and to provide impartial and independent evaluation of approaches, and to provide technological inputs for regulating functions.

Mina Shaughnessy in the 1990s: Some Changing Answers in Basic Writing.

ERIC Educational Resources Information Center

McAlexander, Patricia J.

Although Mina Shaughnessy remains influential in the basic writing field, her answers to the vital questions of who basic writers are and why they underachieve as writers are changing. Whether she intended to or not, Shaughnessy's book "Errors and Expectations" (published in 1977) was a major force in forming an image of basic writers as…

Ethnic Differences and Motivation Based on Maslow's Theory on Iranian Employees.

PubMed

Mousavi, Seyed Hadi; Dargahi, Hossein

2013-01-01

The aim of this study was to assess the levels of Maslow's hierarchy of needs theory had been fulfilled and to compare the Maslow's hierarchy of needs among Iranian different ethnic groups at Tehran University of Medical Sciences (TUMS). This research was a descriptive-analytical study which conducted among administrative employees of Tehran University of Medical Sciences; Tehran, Iran. The structured questionnaire consisted of 20 questions and demographic details. Each question had 4 parts to measure Maslow's hierarchy of needs. The questionnaire was distributed randomly among 133 employees to fill-up the demographic details and the other questions. Data was collected and analyzed by SPSS software, and One Way ANOVA, T-test, Spearman and Mann Whitney statistical methods. TUMS ethnic groups of the employees placed most importance on Basic, Self-esteem and Self-actualization. In addition, we found that Persians, Mazandaranians, and Turks ethnic groups, scored the most mean for Maslow's hierarchical needs compared to the other ethnic groups. Basic needs and safety needs is available amongst the different ethnic groups in Iran. As though, self-actualization needs are ultimate human goal, Iranian employees' ethnic groups pay emphasis on these needs. We believe that new structures and work practices such as prevailing cultural values and beliefs of the society or the organizations must be explored if Iranian-based organizations want to remain responsive to the needs of the workplace.

A policy analysis of adult literacy promotion in the Third World: An accounting of promises made and promises fulfilled

NASA Astrophysics Data System (ADS)

Bhola, H. S.

1985-09-01

To the individual, literacy has promised a new mentality, a new social definition, and new economic capacities. At the collective level, literacy has promised modernization of institutions, democratization of political systems, and cultural renewal of societies in the Third World. Have the promises of literacy been fulfilled? The processes of policy formulation, policy analysis and policy assessment are essentially social processes and a search for `proof' of the effects of literacy is naive, to say the least. What we need is a position on literacy promotion that is plausible, credible and probable, and thereby compelling for action. While both the enthusiasts for literacy and the sceptics continue to draw different conclusions from the same research and experience, a consensus is emerging that the question `Why Literacy?' should now be laid to rest. The question to ask now should be: `How Literacy?' In regard to the question of `How Literacy?', there are two basic positions: Should literacy be taught within the specific small-frame of the selective and intensive approach to literacy, with the provision of basic needs? Or, should literacy be taught within a large-frame of literacy as a `potential added', on a mass-scale and with the political orientation? This paper clearly opts for literacy as generative rather than merely instrumental.

The role of pediatricians as innovators in pediatric nutrition.

PubMed

Greer, Frank R

2010-01-01

Innovation is about making changes. When it comes to health care, innovations, though they may be something 'new', may not be beneficial if not demonstrated to be an improvement over what is current practice. Innovations in pediatric nutrition sometimes fall into this category. The establishment of safe water and milk supplies at the end of the 19th and beginning of the 20th centuries is viewed as one of the greatest advances in preventative medicine and truly was an 'innovation', with its dramatic impact on infant mortality. Other innovations in pediatric nutrition included the development of the caloric method of infant feeding which led to the large-scale adoption of a single infant formula. This required cooperation with industry and ultimately led to the development of life-saving specialty formulas for various disease states including inborn errors of metabolism. Over the last 50 years there have been further modifications of term infant formula that have included taurine, carnitine, nucleotides, whey proteins, PUFAs including decosahexenoic acid (DHA) and arachidonic acid, probiotics, and prebiotics. Many of these additions are of questionable benefit and are questioned as true innovations. Though the addition of novel nutrients to infant formula has been an area of great interest, more basic research (including randomized controlled trial) is needed to determine many pediatric nutrient requirements including the lower and upper limits of nutrients added to infant formula. Such research could be facilitated by institutions such as the US National Institute of Child Health whose establishment in 1962 was a significant 'innovation' as it led to advances in pediatric nutritional research. Much more research is needed to determine basic pediatric nutritional requirements and pediatricians should strive for such true innovations. Copyright © 2010 S. Karger AG, Basel.

Research Gaps in Wilderness Medicine.

PubMed

Tritz, Daniel; Dormire, Kody; Brachtenbach, Travis; Gordon, Joshua; Sanders, Donald; Gearheart, David; Crawford, Julia; Vassar, Matt

2018-05-18

Wilderness medicine involves the treatment of individuals in remote, austere environments. Given the high potential for injuries as well as the unique treatment modalities required in wilderness medicine, evidence-based clinical practice guidelines are necessary to provide optimal care. In this study, we identify evidence gaps from low-quality recommendations in wilderness medicine clinical practice guidelines and identify new/ongoing research addressing them. We included relevant clinical practice guidelines from the Wilderness Medical Society and obtained all 1C or 2C level recommendations. Patient/Problem/Population, intervention, comparison, outcome (PICO) questions were created to address each recommendation. Using 24 search strings, we extracted titles, clinical trial registry number, and recruitment status for 8899 articles. We categorized the articles by trial design to infer the effect they may have on future recommendations. Twelve clinical practice guidelines met inclusion criteria. From these we located 275 low-quality recommendations and used them to create 275 PICO questions. Thirty-three articles were relevant to the PICO questions. Heat-related illness had the highest number of relevant articles (n=9), but acute pain and altitude sickness had the most randomized clinical trials (n=6). Overall, few studies were being conducted to address research gaps in wilderness medicine. Heat-related illness had the most new or ongoing research, whereas no studies were being conducted to address gaps in eye injuries, basic wound management, or spine immobilization. Animals, cadavers, and mannequin research are useful in cases in which human evidence is difficult to obtain. Establishing research priorities is recommended for addressing research gaps identified by guideline panels. Copyright © 2018 Wilderness Medical Society. Published by Elsevier Inc. All rights reserved.

Translational atherosclerosis research: From experimental models to coronary artery disease in humans.

PubMed

Gleissner, Christian A

2016-05-01

Atherosclerosis is the leading cause of death worldwide. Research on the pathophysiological mechanisms of atherogenesis has made tremendous progress over the past two decades. However, despite great advances there is still a lack of therapies that reduce adverse cardiovascular events to an acceptable degree. This review addresses successes, but also questions, challenges, and chances regarding the translation of basic science results into clinical practice, i.e. the capability to apply the results of basic and/or clinical research in order to design therapies suitable to improve patient outcome. Specifically, it discusses problems in translating findings from the most broadly used murine models of atherosclerosis into clinically feasible therapies and strategies potentially improving the results of clinical trials. Most likely, the key to success will be a multimodal approach employing novel imaging methods as well as large scale screening tools-summarized as "omics" approach. Using individually tailored therapies, plaque stabilization and regression could prevent adverse cardiovascular events thereby improving outcome of a large number of patients. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Visualization: a tool for enhancing students' concept images of basic object-oriented concepts

NASA Astrophysics Data System (ADS)

Cetin, Ibrahim

2013-03-01

The purpose of this study was twofold: to investigate students' concept images about class, object, and their relationship and to help them enhance their learning of these notions with a visualization tool. Fifty-six second-year university students participated in the study. To investigate his/her concept images, the researcher developed a survey including open-ended questions, which was administered to the participants. Follow-up interviews with 12 randomly selected students were conducted to explore their answers to the survey in depth. The results of the first part of the research were utilized to construct visualization scenarios. The students used these scenarios to develop animations using Flash software. The study found that most of the students experienced difficulties in learning object-oriented notions. Overdependence on code-writing practice and examples and incorrectly learned analogies were determined to be the sources of their difficulties. Moreover, visualization was found to be a promising approach in facilitating students' concept images of basic object-oriented notions. The results of this study have implications for researchers and practitioners when designing programming instruction.

[Impacts of cross-habitat resource subsidies on ecosystems: A review.

PubMed

Zhang, Yi Xin; Xiang, Hong Yong

2017-02-01

The flux of matter, energy and nutrients across ecosystems, i.e., resource subsidy, is a fundamental attribute of ecosystems, as well as one of basic research questions in ecology. Common subsidies include leaf litter and terrestrial insects that fall into waters, the adults of aquatic insects, spawning salmon. The allocthonous input of resource subsidy can influence individual organisms, populations, communities, biodiversity and ecosystem functioning, such as enhancing individual growth, increasing species abundance and diversity, affecting community structure, enhancing secondary productivity, influencing food-chain length and food web. Due to increased human impacts on environments, especially at aspects of land use, climate change and invasive species, the influence of anthropogenic disturbance on cross-ecosystem resource subsidies will be intensified at both spacial and temporary scales, so that ecosystems will face severer threats. Accordingly, future ecological researches in this field should emphasize the following aspects: impacts of single and multiple stressors on subsidies and ecosystems, implementation of dynamic resource subsidies on ecosystem restoration and management, the dark sides of subsidy relating with pollutants, and basic ecological research on cross-ecosystem resource subsidy in tropics and sub-tropics, as well in China.

[Environmental Hazards Assessment Program annual report, June 1992--June 1993]. Summer undergraduate research program: Environmental studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

McMillan, J.

1993-12-01

The purpose of the summer undergraduate internship program for research in environmental studies is to provide an opportunity for well-qualified students to undertake an original research project as an apprentice to an active research scientist in basic environmental research. Ten students from throughout the midwestern and eastern areas of the country were accepted into the program. These students selected projects in the areas of marine sciences, biostatistics and epidemiology, and toxicology. The research experience for all these students and their mentors was very positive. The seminars were well attended and the students showed their interest in the presentations and environmentalmore » sciences as a whole by presenting the speakers with thoughtful and intuitive questions. This report contains the research project written presentations prepared by the student interns.« less

Thrombosis in Cancer: Research Priorities Identified by a National Cancer Institute/National Heart, Lung, and Blood Institute Strategic Working Group.

PubMed

Key, Nigel S; Khorana, Alok A; Mackman, Nigel; McCarty, Owen J T; White, Gilbert C; Francis, Charles W; McCrae, Keith R; Palumbo, Joseph S; Raskob, Gary E; Chan, Andrew T; Sood, Anil K

2016-07-01

The risk for venous thromboembolism (VTE) is increased in cancer and particularly with chemotherapy, and it portends poorer survival among patients with cancer. However, many fundamental questions about cancer-associated VTE, or Trousseau syndrome, remain unanswered. This report summarizes the proceedings of a working group assembled by the NCI and NHLBI in August 2014 to explore the state of the science in cancer-associated VTE, identify clinically important research gaps, and develop consensus on priorities for future research. Representing a convergence of research priorities between the two NIH Institutes, the workshop addressed epidemiologic, basic science, clinical, and translational issues in cancer-associated VTE. Cancer Res; 76(13); 3671-5. ©2016 AACR. ©2016 American Association for Cancer Research.

Questions of Brain Hemispheric Specialization and Gender Difference in Spatial Tests.

ERIC Educational Resources Information Center

McWhinnie, Harold J.

This paper presents a review of selected literature relevant to a general question of hemispheric specialization (right or left brain) and questions of gender differences in spatial abilities among a group of art students. Three basic questions for discussion are proposed: (1) is there a relationship between hemispheric dominance and spatial…

Proceedings From the Turner Resource Network Symposium: The Crossroads of Health Care Research and Health Care Delivery

PubMed Central

Backeljauw, Philippe F.; Bondy, Carolyn; Chernausek, Steven D.; Cernich, Joseph T.; Cole, David A.; Fasciano, Laura P.; Foodim, Joan; Hawley, Scott; Hong, David S.; Knickmeyer, Rebecca C.; Kruszka, Paul; Lin, Angela E.; Lippe, Barbara M.; Lorigan, Gary A.; Maslen, Cheryl L.; Mauras, Nelly; Page, David C.; Pemberton, Victoria L.; Prakash, Siddharth K.; Quigley, Charmian A.; Ranallo, Kelly C.; Reiss, Allan L.; Sandberg, David E.; Scurlock, Cindy; Silberbach, Michael

2016-01-01

Turner syndrome, a congenital condition that affects ∼1/2,500 births, results from absence or structural alteration of the second sex chromosome. There has been substantial effort by numerous clinical and genetic research groups to delineate the clinical, pathophysiological, cytogenetic, and molecular features of this multisystem condition. Questions about the molecular-genetic and biological basis of many of the clinical features remain unanswered, and health care providers and families seek improved care for affected individuals. The inaugural “Turner Resource Network (TRN) Symposium” brought together individuals with Turner syndrome and their families, advocacy group leaders, clinicians, basic scientists, physician-scientists, trainees and other stakeholders with interest in the well-being of individuals and families living with the condition. The goal of this symposium was to establish a structure for a TRN that will be a patient-powered organization involving those living with Turner syndrome, their families, clinicians, and scientists. The TRN will identify basic and clinical questions that might be answered with registries, clinical trials, or through bench research to promote and advocate for best practices and improved care for individuals with Turner syndrome. The symposium concluded with the consensus that two rationales justify the creation of a TRN: inadequate attention has been paid to the health and psychosocial issues facing girls and women who live with Turner syndrome;investigations into the susceptibility to common disorders such as cardiovascular or autoimmune diseases caused by sex chromosome deficiencies will increase understanding of disease susceptibilities in the general population. PMID:25920614

Conceptual versus Algorithmic Learning in High School Chemistry: The Case of Basic Quantum Chemical Concepts--Part 1. Statistical Analysis of a Quantitative Study

ERIC Educational Resources Information Center

Papaphotis, Georgios; Tsaparlis, Georgios

2008-01-01

Part 1 of the findings are presented of a quantitative study (n = 125) on basic quantum chemical concepts taught in the twelfth grade (age 17-18 years) in Greece. A paper-and-pencil test of fourteen questions was used. The study compared performance in five questions that tested recall of knowledge or application of algorithmic procedures (type-A…

Impact of Hearing Aid Technology on Outcomes in Daily Life I: the Patients’ Perspective

PubMed Central

Cox, Robyn M; Johnson, Jani A; Xu, Jingjing

2016-01-01

Objectives One of the challenges facing hearing care providers when recommending hearing aids is the choice of device technology level. Major manufacturers market families of hearing aids that are described as spanning the range from basic technology to premium technology. Premium technology hearing aids include acoustical processing capabilities (features) that are not found in basic technology instruments. These premium features are intended to yield improved hearing in daily life compared to basic-feature devices. However, independent research that establishes the incremental effectiveness of premium-feature devices compared to basic-feature devices is lacking. This research was designed to explore reported differences in hearing abilities for adults using premium-feature and basic-feature hearing aids in their daily lives. Design This was a single-blinded, repeated, crossover trial in which the participants were blinded. All procedures were carefully controlled to limit researcher bias. Forty-five participants used carefully fitted bilateral hearing aids for one month and then provided data to describe the hearing improvements or deficiencies noted in daily life. Typical participants were 70 years old with mild to moderate adult-onset hearing loss bilaterally. Each participant used 4 pairs of hearing aids: premium- and basic-feature devices from brands marketed by each of two major manufacturers. Participants were blinded about the devices they used and about the research questions. Results All of the outcomes were designed to capture the participant’s point of view about the benefits of the hearing aids. Three types of data were collected: change in hearing-related quality of life, extent of agreement with six positively worded statements about everyday hearing with the hearing aids, and reported preferences between the premium- and basic-feature devices from each brand as well as across all four research hearing aids combined. None of these measures yielded a statistically significant difference in outcomes between premium- and basic-feature devices. Participants did not report better outcomes with premium processing with any measure. Conclusions It could reasonably be asserted that the patient’s perspective is the gold standard for hearing aid effectiveness. While the acoustical processing provided by premium features can potentially improve scores on tests conducted in contrived conditions in a laboratory, or on specific items in a questionnaire, this does not ensure that the processing will be of noteworthy benefit when the hearing aid is used in the real world challenges faced by the patient. If evidence suggests the patient cannot detect that premium features yield improvements over basic features in daily life, what is the responsibility of the provider in recommending hearing aid technology level? In the current research, there was no evidence to suggest that premium-feature devices yielded better outcomes than basic-feature devices from the patient’s point of view. All of the research hearing aids were substantially, but equally, helpful. Further research is needed on this topic with other hearing aids and other manufacturers. In the meantime, providers should insist on scientifically credible independent evidence to support effectiveness claims for any hearing help devices. PMID:26881981

Viewpoint: Back to the Basics in Social Studies? Personal Statements by Three Canadian Educators

ERIC Educational Resources Information Center

Sutherland, Neil; And Others

1977-01-01

Neil Sutherland discusses the historical context of the back to basics movement in social studies. Ken Osborne points out that the movement is stifling innovation. Max van Manen addresses the question of what curricula should be considered basic. (Author/RM)

MAD Submission Form

Science.gov Websites

best answered by professional advice/consulting. Questions concerning the development of commercial products or the operation of a commercial organization. Questions answered by basic references, such as

PREFACE: Ferrofluids

NASA Astrophysics Data System (ADS)

Odenbach, Professor Stefan

2006-09-01

This issue of Journal of Physics: Condensed Matter is dedicated to results in the field of ferrofluid research. Ferrofluids—suspensions of magnetic nanoparticles—exhibit as a specific feature the magnetic control of their physical parameters and of flows appearing in such fluids. This magnetic control can be achieved by means of moderate magnetic fields with a strength of the order of 10 mT. This sort of magnetic control also enables the design of a wide variety of technical applications such as the use of the magnetic forces for basic research in fluid dynamics. The overall field of ferrofluid research is already about 40 years old. Starting with the first patent on the synthesis of magnetic nanoparticle suspensions by S Papell in 1964, a vivid field of research activities has been established. Looking at the long time in which ferrofluids have been the focus of scientific interest, one can ask the question, what kind of recent developments justify a special issue of a scientific journal? New developments in a field, which depends strongly on a certain material class and which opens research possibilities in different scientific fields will nowadays usually require an interdisciplinary approach. This kind of approach starting from the synthesis of magnetic suspensions, including research concerning their basic properties and flow behaviour and focusing on new applications has been the core of a special research programme funded by the Deutsche Forschungsgemeinschaft (DFG) over the past 6 years. Within this programme—entitled `Colloidal Magnetic Fluids: Basics, Synthesis and Applications of New Ferrofluids'—more than 30 different research groups have been coordinated to achieve new results in various fields related to ferrofluid research. The basic approach of the program has been the assumption that new applications well beyond the typical ferrofluid techniques, for example loud speaker cooling or sealing of rotary shafts, will require tailored magnetic suspensions with properties clearly focused towards the need of the application. While such tailoring of fluids to certain well defined properties sounds like a straightforward approach one has to face the fact that it requires a clear definition of the required properties. This definition itself has to be based on a fundamental physical knowledge of the processes determining certain magnetically controlled phenomena in ferrofluids. To make this point concrete one can look into the detailed aims of the mentioned research program. The application areas identified for the future development of research and application of suspensions of magnetic nanoparticles have been on the one hand the biomedical application—especially with respect to cancer treatment—and on the other hand the use of magnetically controlled rheological properties of ferrofluids for new active technical devices. Both directions require, as mentioned, as a basis for success the synthesis of new ferrofluids with dedicated properties. While the medical applications have to rely on biocompatibility as well as on stability of the suspensions in a biomedical environment, the use of ferrofluids in technical devices employing their magnetically controlled rheological properties will depend on an enhancement of the changes of the fluid's viscous properties in the presence of moderate magnetic fields. For both requirements ferrofluids with a make up clearly different from the usual magnetite based fluids have to be synthesized. The question of how the detailed microscopic make up of the fluids would have to look has to be answered on the basis of basic research results defining the physics background of the respective phenomena. Taking these aspects together it becomes obvious that the aforementioned research program had goals aiming far beyond the state of the art of classical ferrofluid research. These goals as well as the basic strategy to achieve them is in a way reflected by the structure of this issue of Journal of Physics: Condensed Matter. The issue contains results emerging from the research programme as well as invited papers from researchers not participating in the programme but working in closely related areas. The issue is subdivided into five main sections dealing with synthesis, basic physical description, rheology, and both the medical and technical applications of ferrofluids. As can be expected from work done within an interdisciplinary context many of the papers would fit into more than one of these sections and catagorization is thus sometimes difficult. We have therefore tried to place them into the section reflecting the main field of research to which the respective results belong. The first section is on synthesis and characterization of magnetic suspensions. The first paper in this section is dedicated partly to magnetite ferrofluids but with special aspects concerning the particle size tailoring them for applications especially in the field of magnetic hyperthermia. After this, three different types of `new' ferrofluids are presented. Fluids based on pure metal particles exhibiting much stronger magnetic properties than the common magnetite fluids, fluids with a temperature sensitive surfactant shell allowing a change of the particle’s hydrodynamic diameter by variation of the fluid’s temperature and fluids containing spheres of nonmagnetic material with embedded magnetic particles which are already used in new medical applications. The second section is dedicated to the basic physics of ferrofluids and highlights three different topics. First the question of magnetization dynamics is discussed and different aspects of this fundamental problem, which determines the basic description of ferrofluids, are highlighted. The second topic is the well known surface instability appearing in ferrofluids in a homogeneous magnetic field perpendicular to the fluid surface. This part shows clearly how many undiscovered phenomena can be found, even in an area which is as old as the whole research field, if an appropriate measuring technique is used and fresh ideas help to find unexpected effects. The last part of this section deals with the question of dynamics and structure of ferrofluids and shows the experimental possibilities of scattering techniques in this field. Within the third section the question of field dependent changes of the rheological behaviour of ferrofluids is discussed. The first three papers provide theoretical approaches for the understanding of the connection between the rheological properties and shear and field induced changes in the fluid’s microstructure. The fourth paper provides the related experimental results showing the combination of microstructural and rheological measurements under well defined conditions. The last paper of this section does not directly belong to ferrofluid research but to a closely related field—so called magneto-rheological (MR) suspensions, which differ from ferrofluids mainly by the size of the suspended particles and the strength of the rheological effects. As modern theoretical approaches, like the one discussed by Liu et al in the second section have shown, the relation between the effects in ferrofluids and those in MR fluids is so close that it could probably be described in a common theory. Sections four and five contain the application orientated results. In the fourth section the medical applications are the focus of interest. The section starts with a paper which could have also been placed in the synthesis section—the growth of magnetotactic bacteria and the extraction of the magnetic particles produced by these bacteria. The paper also contains information about the characterization of the particles especially with respect to their application. The characterization aspect is then continued in two papers outlining new diagnostic techniques with close relation to future biomedical application of magnetic fluids. Next in vitro applications, especially questions of cell separation using magnetic forces, are highlighted before the final papers address the therapeutic aspects of magnetic drug targeting and magnetic hyperthermia. Finally the fifth section describes three different new approaches for the technical use of ferrofluids. Again, the specialized design of the fluids themselves is an important step towards the new application goals. Altogether the papers within this issue outline the unique potential of magnetically controlled suspensions, the interdisciplinary nature of the related research and the prospects of strongly networked and interdisciplinary activities in the field. I hope that it will give an insight into the fascination of ferrofluid research and a feeling for the advances made in the past years.

Breastfeed Your Baby

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... Basics: Health Benefits What are the benefits of breastfeeding? Breastfeeding gives you and your baby time to ... Basics: Common Questions If you are worried about breastfeeding, you aren't alone. It's normal to have ...

Phase-Transition-Induced Pattern Formation Applied to Basic Research on Homeopathy: A Systematic Review.

PubMed

Kokornaczyk, Maria Olga; Scherr, Claudia; Bodrova, Natalia Borisovna; Baumgartner, Stephan

2018-05-16

 Methods based on phase-transition-induced pattern formation (PTPF) are increasingly used in medical research. Frequent application fields are medical diagnosis and basic research in homeopathy. Here, we present a systematic review of experimental studies concerning PTPF-based methods applied to homeopathy research. We also aimed at categorizing the PTPF methods included in this review.  Experimental studies were collected from scientific databases (PubMed, Web of Science, Russian eLibrary) and from experts in the research field in question, following the PRISMA guidelines. The studies were rated according to pre-defined scientific criteria.  The review included 15 experimental studies. We identified seven different PTPF methods applied in 12 experimental models. Among these methods, phase-transition was triggered through evaporation, freezing, or solution, and in most cases led to the formation of crystals. First experimental studies concerning the application of PTPF methods in homeopathic research were performed in the first half of the 20th century; however, they were not continued in the following years. Only in the last decade, different research groups re-launched the idea, introducing new experimental approaches and computerized pattern evaluation techniques. The here-identified PTPF methods are for the first time proposed to be classified as one group of methods based on the same basic physical phenomenon.  Although the number of experimental studies in the area is still rather limited, the long tradition in the application of PTPF methods and the dynamics of the present developments point out the high potential of these methods and indicate that they might meet the demand for scientific methods to study potentized preparations. The Faculty of Homeopathy.

Qualitative Research in Palliative Care: Applications to Clinical Trials Work.

PubMed

Lim, Christopher T; Tadmor, Avia; Fujisawa, Daisuke; MacDonald, James J; Gallagher, Emily R; Eusebio, Justin; Jackson, Vicki A; Temel, Jennifer S; Greer, Joseph A; Hagan, Teresa; Park, Elyse R

2017-08-01

While vast opportunities for using qualitative methods exist within palliative care research, few studies provide practical advice for researchers and clinicians as a roadmap to identify and utilize such opportunities. To provide palliative care clinicians and researchers descriptions of qualitative methodology applied to innovative research questions relative to palliative care research and define basic concepts in qualitative research. Body: We describe three qualitative projects as exemplars to describe major concepts in qualitative analysis of early palliative care: (1) a descriptive analysis of clinician documentation in the electronic health record, (2) a thematic content analysis of palliative care clinician focus groups, and (3) a framework analysis of audio-recorded encounters between patients and clinicians as part of a clinical trial. This study provides a foundation for undertaking qualitative research within palliative care and serves as a framework for use by other palliative care researchers interested in qualitative methodologies.

Grass buffers for playas in agricultural landscapes: A literature synthesis

USGS Publications Warehouse

Melcher, Cynthia P.; Skagen, Susan K.

2005-01-01

Future research should entail multiple-scale approaches at regional, wetland-complex, and individual watershed scales. Information needs include direct measures of buffer effectiveness in ‘real-world’ systems, refinement and field tests of buffer-effectiveness models, how buffers may affect floral and faunal communities of playas, and basic ecological information on playa function and playa wildlife ecology. Understanding how wildlife communities respond to patch size and habitat fragmentation is crucial for addressing questions regarding habitat quality of grass buffers in playa systems.

Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics.

PubMed

Puré, Ellen; Blomberg, Rachel

2018-05-03

Fibroblast activation protein (FAP) is a cell-surface serine protease that acts on various hormones and extracellular matrix components. FAP is highly upregulated in a wide variety of cancers, and is often used as a marker for pro-tumorigenic stroma. It has also been proposed as a molecular target of cancer therapies, and, especially in recent years, a great deal of research has gone into design and testing of diverse FAP-targeted treatments. Yet despite this growing field of research, our knowledge of FAP's basic biology and functional roles in various cancers has lagged behind its use as a tumor-stromal marker. In this review, we summarize and analyze recent advances in understanding the functions of FAP in cancer, most notably its prognostic value in various tumor types, cellular effects on various cell types, and potential as a therapeutic target. We highlight outstanding questions in the field, the answers to which could shape preclinical and clinical studies of FAP.

Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity.

PubMed

Epel, Elissa S; Lithgow, Gordon J

2014-06-01

The rate of biological aging is modulated in part by genes interacting with stressor exposures. Basic research has shown that exposure to short-term stress can strengthen cellular responses to stress ("hormetic stress"). Hormetic stress promotes longevity in part through enhanced activity of molecular chaperones and other defense mechanisms. In contrast, prolonged exposure to stress can overwhelm compensatory responses ("toxic stress") and shorten lifespan. One key question is whether the stressors that are well understood in basic models of aging can help us understand psychological stressors and human health. The psychological stress response promotes regulatory changes important in aging (e.g., increases in stress hormones, inflammation, oxidative stress, insulin). The negative effects of severe stress are well documented in humans. Potential positive effects of acute stress (stress resistance) are less studied, especially at the cellular level. Can stress resistance slow the rate of aging in humans, as it does in model organisms? If so, how can we promote stress resistance in humans? We urge a new research agenda embracing the continuum from cellular stress to psychological stress, using basic and human research in tandem. This will require interdisciplinary novel approaches that hold much promise for understanding and intervening in human chronic disease. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Information processing as a paradigm for decision making.

PubMed

Oppenheimer, Daniel M; Kelso, Evan

2015-01-03

For decades, the dominant paradigm for studying decision making--the expected utility framework--has been burdened by an increasing number of empirical findings that question its validity as a model of human cognition and behavior. However, as Kuhn (1962) argued in his seminal discussion of paradigm shifts, an old paradigm cannot be abandoned until a new paradigm emerges to replace it. In this article, we argue that the recent shift in researcher attention toward basic cognitive processes that give rise to decision phenomena constitutes the beginning of that replacement paradigm. Models grounded in basic perceptual, attentional, memory, and aggregation processes have begun to proliferate. The development of this new approach closely aligns with Kuhn's notion of paradigm shift, suggesting that this is a particularly generative and revolutionary time to be studying decision science.

[Basic concepts for network meta-analysis].

PubMed

Catalá-López, Ferrán; Tobías, Aurelio; Roqué, Marta

2014-12-01

Systematic reviews and meta-analyses have long been fundamental tools for evidence-based clinical practice. Initially, meta-analyses were proposed as a technique that could improve the accuracy and the statistical power of previous research from individual studies with small sample size. However, one of its main limitations has been the fact of being able to compare no more than two treatments in an analysis, even when the clinical research question necessitates that we compare multiple interventions. Network meta-analysis (NMA) uses novel statistical methods that incorporate information from both direct and indirect treatment comparisons in a network of studies examining the effects of various competing treatments, estimating comparisons between many treatments in a single analysis. Despite its potential limitations, NMA applications in clinical epidemiology can be of great value in situations where there are several treatments that have been compared against a common comparator. Also, NMA can be relevant to a research or clinical question when many treatments must be considered or when there is a mix of both direct and indirect information in the body of evidence. Copyright © 2013 Elsevier España, S.L.U. All rights reserved.

Characterizing the Quality Workforce in Private U.S. Child and Family Behavioral Health Agencies.

PubMed

McMillen, J Curtis; Raffol, Matthew

2016-09-01

Behavioral health agencies have been encouraged to monitor performance and improve service quality. This paper characterizes the workforce charged with these tasks through a national survey of 238 behavioral health quality professionals. A latent class analysis suggests only 30 % of these workers report skills in both basic research and quality-specific skills. Respondents wanted to learn a variety of research and data analytic skills. The results call into question the quality of data collected in behavioral health agencies and the conclusions agencies are drawing from their data. Professional school and continuing education programs are needed to prepare this workforce.

The need for targeted implementation research to improve coverage of basic vaccines and introduction of new vaccines.

PubMed

Arora, Narendra K; Lal, Altaf A; Hombach, Joachim M; Santos, Jose I; Bhutta, Zulfiqar A; Sow, Samba O; Greenwood, Brian

2013-04-18

The Decade of Vaccines Collaboration (DoVC) Research and Development (R&D) Working Group identified implementation research as an important step toward achieving high vaccine coverage and the uptake of desirable new vaccines. The R&D Working Group noted that implementation research is highly complex and requires participation of stakeholders from diverse backgrounds to ensure effective planning, execution, interpretation, and adoption of research outcomes. Unlike other scientific disciplines, implementation research is highly contextual and depends on social, cultural, geographic, and economic factors to make the findings useful for local, national, and regional applications. This paper presents the broad framework for implementation research in support of immunization and sets out a series of research questions developed through a Delphi process (during a DoVC-supported workshop in Sitges, Spain) and a literature review. Copyright © 2013 Elsevier Ltd. All rights reserved.

Educational Intervention in a Medically Underserved Area.

PubMed

Atance, Joel; Mickalis, Morgan; Kincade, Brianna

2018-04-01

Medical students from rural and medically underserved areas (MUAs) are more likely than their peers to practice medicine in rural areas and MUAs. However, students from MUAs are also more likely to face socioeconomic barriers to a career in medicine. To determine whether a week-long summer enrichment experience (SEE) at Edward Via College of Osteopathic Medicine-Carolinas could successfully teach high school students from MUAs basic biomedical concepts and foster an interest in medicine and the health sciences. The SEE program is open to high school students in the Spartanburg, South Carolina, area. The program includes interactive lectures, laboratories, demonstrations on gross anatomy prosections, demonstrations on medical simulation models, tours of emergency vehicles, an introduction to osteopathic manipulative medicine, and student-led research projects. Participants were asked to complete a 15-question quiz that assessed their knowledge of basic biomedical concepts and a 10-question survey that assessed their attitudes toward careers in medicine and health sciences. Both the quiz and the survey were completed on both the first and final days of the program. The data were analyzed using paired t tests. Participant knowledge of basic biomedical concepts, as determined by the quiz scores, increased after completion of the program (9.1 average correct answers vs 12.6 average correct answers) (P<.001). Participant attitude toward medicine and the health sciences improved in 9 of the 10 items surveyed after completion of the program (P<.05). Participant knowledge of basic biomedical concepts and their knowledge of and interest in careers in the health sciences improved after completing the SEE program. These findings suggest that educational interventions for high school students could help to develop primary care physicians for rural areas and MUAs and that there is a role for osteopathic medical schools to nurture these students as early as possible.

Expanding the basic science debate: the role of physics knowledge in interpreting clinical findings.

PubMed

Goldszmidt, Mark; Minda, John Paul; Devantier, Sarah L; Skye, Aimee L; Woods, Nicole N

2012-10-01

Current research suggests a role for biomedical knowledge in learning and retaining concepts related to medical diagnosis. However, learning may be influenced by other, non-biomedical knowledge. We explored this idea using an experimental design and examined the effects of causal knowledge on the learning, retention, and interpretation of medical information. Participants studied a handout about several respiratory disorders and how to interpret respiratory exam findings. The control group received the information in standard "textbook" format and the experimental group was presented with the same information as well as a causal explanation about how sound travels through lungs in both the normal and disease states. Comprehension and memory of the information was evaluated with a multiple-choice exam. Several questions that were not related to the causal knowledge served as control items. Questions related to the interpretation of physical exam findings served as the critical test items. The experimental group outperformed the control group on the critical test items, and our study shows that a causal explanation can improve a student's memory for interpreting clinical details. We suggest an expansion of which basic sciences are considered fundamental to medical education.

The ergonomics of learning: educational design and learning performance.

PubMed

Smith, T J

2007-10-01

The application of ergonomics/human factors (E/HF) principles and practices, and the implementation of ergonomics programmes, have achieved proven success in improving performance, productivity, competitiveness, and safety and health in most occupational sectors. However, the benefits that the application of E/HF science might bring to promoting student learning have yet to be widely recognized. This paper deals with the fundamental purpose of education - student learning - and with the question of how the ergonomic design of the learning environment influences learning performance. The underlying premise, embodied in the quote below, is that student learning performance to a substantial degree is context specific - influenced and specialized in relation to specific design factors in the learning environment. The basic scientific question confronting learning ergonomics is which design characteristics in the learning environment have the greatest influence on variability in learning performance. Practically, the basic challenge is to apply this scientific understanding to ergonomic interventions directed at design improvements of learning environments to benefit learning. This paper expands upon these themes by addressing the origins and scope of learning ergonomics, differing perspectives on the nature of learning, evidence for context specificity in learning and conclusions and research implications regarding an ergonomics perspective on learning.

Raising public awareness of aphasia in southern Ontario, Canada: A survey.

PubMed

Patterson, Ruth; Robert, Amélie; Berry, Richard; Cain, Mallory; Iqbal, Maryam; Code, Chris; Rochon, Elizabeth; Leonard, Carol

2015-04-01

Despite the relatively high prevalence of aphasia, research indicates that, world-wide, public awareness of aphasia is lacking. Of the surveys that have been conducted internationally, none has studied the Canadian public's awareness of aphasia. The purpose of the present survey was to assess public awareness and basic knowledge of aphasia of individuals in southern Ontario, Canada. Using the same questionnaire that has been used in other countries, face-to-face surveys were conducted in public places (e.g. parks) at various locations in southern Ontario. Respondents were asked questions pertaining to their awareness and knowledge of aphasia. The number of surveys retained for analysis was 831. In addition to an evaluation of public awareness and knowledge of aphasia, the potential influences of age, gender, and occupation were analysed. For those who had heard of aphasia, questions were asked to determine how or where they had heard of aphasia. Consistent with the literature, overall public awareness and basic knowledge of aphasia in southern Ontario was found to be limited. The factors of age, gender and occupation were found to influence the results. This investigation supports the need for better promotion of aphasia awareness to the public in southern Ontario and, by extension, in Canada.

Advanced Placement Economics. Macroeconomics: Student Activities.

ERIC Educational Resources Information Center

Morton, John S.

This book is designed to help advanced placement students better understand macroeconomic concepts through various activities. The book contains 6 units with 64 activities, sample multiple-choice questions, sample short essay questions, and sample long essay questions. The units are entitled: (1) "Basic Economic Concepts"; (2) "Measuring Economic…

Basic Information about Lead in Drinking Water

MedlinePlus

... Water and Drinking Water Contact Us Share Basic Information about Lead in Drinking Water Have a question ... Related Information from Other Federal Government Agencies General Information about Lead in Drinking Water How Lead Gets ...

Competition Overview Presentation: The basics on competing for EPA assistance programs

EPA Pesticide Factsheets

The basics on competing for EPA assistance programs. Finding EPA Competitive Opportunities and contact the Officer of Grants and Debarment competition staff should you have any additional questions or concerns.

The Style As a Factor of Office Building Concentration Locations in European Cities

NASA Astrophysics Data System (ADS)

Bocian, Anna

2017-03-01

Where should office building concentrations be located in cities? What kind of factors has an influence on its locations? The aim of the research is to examine factors of office locations in cities. Selected office building concentrations in European cities were investigated as case studies. The research method was the spatial decision paradigm. The style, one of the main elements of the paradigm, was selected to answer the research question. The style was defined a composition of existing urban structures. Basic elements of urban composition in selected European cities were examined closely. Research results are conditions of office building concentration locations in European cities in term of urban composition. Such knowledge should be a base of decision-making processe during preparing master plans and city development plans.

Moving Between Discourses: From Learning-As-Acquisition To Learning-As-Participation

NASA Astrophysics Data System (ADS)

Sfard, Anna

2009-11-01

In this paper I address the question of how to talk about learning so as to be able to cope with at least some of the longstanding quandaries and to arrive at new insights. After a very brief historical review, I concentrate on two basic metaphors for learning in which current educational research seems to be grounded: the metaphors of learning-as-acquisition and of learning-as-participation. After stating the importance of both of these approaches and arguing that researches should be adjusting their leading metaphors to the questions they ask, I present my own choice: a brand of participationist discourse which is grounded in the vision of thinking as a form of communication and of physics and mathematics as types of discourses. The usefulness of the proposed way of talking about learning is then illustrated with the help of empirical materials taken from my recent study on a 7th grade class just introduced to negative numbers.

Seeing responsibility: can neuroimaging teach us anything about moral and legal responsibility?

PubMed

Wasserman, David; Johnston, Josephine

2014-01-01

As imaging technologies help us understand the structure and function of the brain, providing insight into human capabilities as basic as vision and as complex as memory, and human conditions as impairing as depression and as fraught as psychopathy, some have asked whether they can also help us understand human agency. Specifically, could neuroimaging lead us to reassess the socially significant practice of assigning and taking responsibility? While responsibility itself is not a psychological process open to investigation through neuroimaging, decision-making is. Over the past decade, different researchers and scholars have sought to use neuroimaging (or the results of neuroimaging studies) to investigate what is going on in the brain when we make decisions. The results of this research raise the question whether neuroscience-especially now that it includes neuroimaging-can and should alter our understandings of responsibility and our related practice of holding people responsible. It is this question that we investigate here. © 2014 by The Hastings Center.

An IACUC Perspective on Songbirds and Their Use in Neurobiological Research

PubMed Central

Schmidt, Marc F.

2011-01-01

Laboratory research using songbirds as a model system for investigating basic questions of neurobiological function has expanded rapidly and recently, with approximately 120 laboratories working with songbirds worldwide. In the United States alone, of the approximately 80 such laboratories nearly a third have been established in the past 10 years. Yet many animal facilities are not outfitted to manage these animals, and as a consequence laboratories often use alternative housing arrangements established by institutional animal care and use committees (IACUCs). These committees invariably differ in their expertise level with birds and thus guidelines also vary considerably from one institution to another. In this article I address a number of factors to consider for effective oversight of research involving songbirds. PMID:21131718

Commercial biotechnology processing thermal control for transfer payloads to/from the International Space Station

NASA Astrophysics Data System (ADS)

Jennings, William M.; Vellinger, John C.; Deuser, Mark S.

2000-01-01

Biotechnology is undergoing a period of rapid and sustained growth, a trend which is expected to continue as the general population ages and as new medical treatments and products are conceived. As pharmaceutical and biomedical companies continue to search for improved methods of production and, for answers to basic research questions, they will seek out new avenues of research. Space processing on the International Space Station (ISS) offers such an opportunity! Space is rapidly becoming an industrial laboratory for biotechnology research and processing. Space bioprocessing offers exciting possibilities for developing new pharmaceuticals and medical treatments which can be used to benefit mankind on Earth. It also represents a new economic frontier for the private sector. .

Short-Term Research Experiences with Teachers in Earth and Planetary Sciences and a Model for Integrating Research into Classroom Inquiry

NASA Astrophysics Data System (ADS)

Morgan, P.; Bloom, J. W.

2006-12-01

For the past three summers, we have worked with in-service teachers on image processing, planetary geology, and earthquake and volcano content modules using inquiry methods that ended with mini-research experiences. Although almost all were science teachers, very few could give a reasonable definition of science at the start of the modules, and very few had a basic grasp of the processes of scientific research and could not include substantive scientific inquiry into their lessons. To build research understanding and confidence, an instructor-student interaction model was used in the modules. Studies have shown that children who participate in classrooms as learning and inquiry communities develop more complex understandings. The same patterns of complex understandings have resulted in similarly structured professional communities of teachers. The model is based on professional communities, emphasizing from the beginning that inquiry is a form of research. Although the actual "research" component of the modules was short, the teachers were identified as professionals and researchers from the start. Research/inquiry participation is therefore an excellent example by which to allow their teachers to learn. Initially the teachers were very reluctant to pose questions. As they were encouraged to share, collaborate, and support each other, the role of the instructor became less of a leader and more of a facilitator, and the confidence of the teachers as professionals and researchers grew. One teacher even remarked, "This is how we should be teaching our kids!' Towards the end of the modules the teachers were ready for their mini- research projects and collaborated in teams of 2-4. They selected their own research topics, but were guided toward research questions that required data collection (from existing studies), some data manipulation, interpretation, and drawing conclusions with respect to the original question. The teachers were enthusiastic about all of their research experiences and overall expressed a new understanding of science and research.

The Role of the Clinical and Translational Science Awards Program in Improving the Quality and Efficiency of Clinical Research

PubMed Central

Rosenblum, Daniel

2011-01-01

Recognizing the need to increase the efficiency and quality of translating basic discovery into treatment and prevention strategies for patients and the public, the National Institutes of Health (NIH) announced the Clinical and Translational Science Awards (CTSAs) in 2006. Academic health centers that competed successfully for these awards agreed to work as a consortium and in cooperation with the NIH to improve the translation process by training the next generation of investigators to work in interdisciplinary teams, developing public-private partnerships in the movement of basic discovery to preclinical and clinical studies and trials, improving clinical research management, and engaging with communities to ensure their involvement in shaping research questions and in implementing research results. The CTSAs have addressed the crucial need to improve the quality and efficiency of clinical research by (1) providing training for clinical investigators and for bench researchers to facilitate their participation in the clinical and translational research environment, (2) developing more systematic approaches to clinical research management, and (3) engaging communities as active participants in the design and conduct of clinical research studies and trials and as leaders in implementing health advances that are of high importance to them. We provide an overview of the CTSA activities with attention to these three areas, which are essential to developing efficient clinical research efforts and effective implementation of research results on a national level. PMID:21896519

Adult Basic Education Materials Evaluation Guide.

ERIC Educational Resources Information Center

Harrison, David

This guide is intended for use by adult basic education practitioners in the screening of basic reading textbooks prior to their adoption for classroom use. The guide is in the form of a questionnaire and consists of dichotomous-choice questions arranged into three sections that relate to the product design, adult learning, and reading instruction…

Basic Relationships among Scale, Quality, and Benefits in Sino-Foreign Cooperative Education

ERIC Educational Resources Information Center

Lin, Jinhui

2016-01-01

The basic relationships among scale, quality, and benefits in Sino-foreign cooperative education are key to the development of cooperative education. It is necessary to construct a theoretical framework for the basic relationships among scale, quality, and benefits in Sino-foreign cooperative education and analyze the questions faced in…

The Importance of Incorporating Multiculturalism in Basic Communication Courses.

ERIC Educational Resources Information Center

Funkhouser, Edward T.

Multiculturalism has a place in basic communication courses. At a personal level, cross-cultural communication is concerned with the way a person chooses to treat another--it is a question of communication ethics, a subject that should be introduced in any basic communication course because communicators must consider how to deal fairly and…

Operational Research during the Ebola Emergency.

PubMed

Fitzpatrick, Gabriel; Decroo, Tom; Draguez, Bertrand; Crestani, Rosa; Ronsse, Axelle; Van den Bergh, Rafael; Van Herp, Michel

2017-07-01

Operational research aims to identify interventions, strategies, or tools that can enhance the quality, effectiveness, or coverage of programs where the research is taking place. Médecins Sans Frontières admitted ≈5,200 patients with confirmed Ebola virus disease during the Ebola outbreak in West Africa and from the beginning nested operational research within its emergency response. This research covered critical areas, such as understanding how the virus spreads, clinical trials, community perceptions, challenges within Ebola treatment centers, and negative effects on non-Ebola healthcare. Importantly, operational research questions were decided to a large extent by returning volunteers who had first-hand knowledge of the immediate issues facing teams in the field. Such a method is appropriate for an emergency medical organization. Many challenges were also identified while carrying out operational research across 3 different countries, including the basic need for collecting data in standardized format to enable comparison of findings among treatment centers.

Sexual Violence and HIV Transmission: Summary Proceedings of a Scientific Research Planning Meeting

PubMed Central

Klot, Jennifer F.; Auerbach, Judith D.; Berry, Miranda R.

2013-01-01

This summarizes proceedings of a Scientific Research Planning Meeting on Sexual Violence and HIV transmission, convened by the Social Science Research Council on 19–20 March 2012 at the Greentree Foundation in New York. The Meeting brought together an interdisciplinary group of basic, clinical, epidemiological and social science researchers and policy makers with the aim of: (1) examining what is known about the physiology of sexual violence and its role in HIV transmission, acquisition and pathogenesis; (2) specifying factors that distinguish risks throughout the maturation of the female genital tract, the reproductive cycle and among post-menopausal women; and (3) developing a research agenda to explore unanswered questions. The Meeting resulted in a consensus Research Agenda and White Paper that identify priorities for HIV research, policy and practice as it pertains to the role of sexual violence and genital injury in HIV transmission, acquisition and pathogenesis, particularly among women and girls. PMID:23157400

A Trait-Based Approach to Advance Coral Reef Science.

PubMed

Madin, Joshua S; Hoogenboom, Mia O; Connolly, Sean R; Darling, Emily S; Falster, Daniel S; Huang, Danwei; Keith, Sally A; Mizerek, Toni; Pandolfi, John M; Putnam, Hollie M; Baird, Andrew H

2016-06-01

Coral reefs are biologically diverse and ecologically complex ecosystems constructed by stony corals. Despite decades of research, basic coral population biology and community ecology questions remain. Quantifying trait variation among species can help resolve these questions, but progress has been hampered by a paucity of trait data for the many, often rare, species and by a reliance on nonquantitative approaches. Therefore, we propose filling data gaps by prioritizing traits that are easy to measure, estimating key traits for species with missing data, and identifying 'supertraits' that capture a large amount of variation for a range of biological and ecological processes. Such an approach can accelerate our understanding of coral ecology and our ability to protect critically threatened global ecosystems. Copyright © 2016 Elsevier Ltd. All rights reserved.

Basic Principles of Magnetic Resonance Imaging—An Update

PubMed Central

Scherzinger, Ann L.; Hendee, William R.

1985-01-01

Magnetic resonance (MR) imaging technology has undergone many technologic advances over the past few years. Many of these advances were stimulated by the wealth of information emerging from nuclear magnetic resonance research in the areas of new and optimal scanning methods and radio-frequency coil design. Other changes arose from the desire to improve image quality, ease siting restrictions and generally facilitate the clinical use of MR equipment. Many questions, however, remain unanswered. Perhaps the most controversial technologic question involves the optimal field strength required for imaging or spectroscopic applications or both. Other issues include safety and clinical efficacy. Technologic issues affect all aspects of MR use including the choice of equipment, examination procedure and image interpretation. Thus, an understanding of recent changes and their theoretic basis is necessary. ImagesFigure 9. PMID:3911591

Ethical issues in nanomedicine: Tempest in a teapot?

PubMed

Allon, Irit; Ben-Yehudah, Ahmi; Dekel, Raz; Solbakk, Jan-Helge; Weltring, Klaus-Michael; Siegal, Gil

2017-03-01

Nanomedicine offers remarkable options for new therapeutic avenues. As methods in nanomedicine advance, ethical questions conjunctly arise. Nanomedicine is an exceptional niche in several aspects as it reflects risks and uncertainties not encountered in other areas of medical research or practice. Nanomedicine partially overlaps, partially interlocks and partially exceeds other medical disciplines. Some interpreters agree that advances in nanotechnology may pose varied ethical challenges, whilst others argue that these challenges are not new and that nanotechnology basically echoes recurrent bioethical dilemmas. The purpose of this article is to discuss some of the ethical issues related to nanomedicine and to reflect on the question whether nanomedicine generates ethical challenges of new and unique nature. Such a determination should have implications on regulatory processes and professional conducts and protocols in the future.

Unequal brothers : are homeopathy and hormesis linked?

PubMed

Oberbaum, Menachem; Frass, Michael; Gropp, Cornelius

2015-04-01

The debate between those who believe homeopathy and hormesis derive from the same root and those who believe the two are different phenomena is as old as hormesis. It is an emotionally loaded discussion, with both sides fielding arguments which are far from scientific. Careful analysis of the basic paradigms of the two systems questions the claim of the homeopaths, who find similarities between them. The authors discuss these paradigms, indicating the differences between the claims of homeopathy and hormesis. It is time for thorough and serious research to lay this question to rest. One possible approach is to compare the activity of a hormetic agent, prepared in the usual way, with that of the same agent in the same concentration prepared homeopathically by serial dilution and succussion. Copyright © 2015. Published by Elsevier Ltd.

Cardiopulmonary discipline science plan

NASA Technical Reports Server (NTRS)

1991-01-01

Life sciences research in the cardiopulmonary discipline must identify possible consequences of space flight on the cardiopulmonary system, understand the mechanisms of these effects, and develop effective and operationally practical countermeasures to protect crewmembers inflight and upon return to a gravitational environment. The long-range goal of the NASA Cardiopulmonary Discipline Research Program is to foster research to better understand the acute and long-term cardiovascular and pulmonary adaptation to space and to develop physiological countermeasures to ensure crew health in space and on return to Earth. The purpose of this Discipline Plan is to provide a conceptual strategy for NASA's Life Sciences Division research and development activities in the comprehensive area of cardiopulmonary sciences. It covers the significant research areas critical to NASA's programmatic requirements for the Extended-Duration Orbiter, Space Station Freedom, and exploration mission science activities. These science activities include ground-based and flight; basic, applied, and operational; and animal and human research and development. This document summarizes the current status of the program, outlines available knowledge, establishes goals and objectives, identifies science priorities, and defines critical questions in the subdiscipline areas of both cardiovascular and pulmonary function. It contains a general plan that will be used by both NASA Headquarters Program Offices and the field centers to review and plan basic, applied, and operational (intramural and extramural) research and development activities in this area.

An extensible and successful method of identifying collaborators for National Library of Medicine informationist projects

PubMed Central

Williams, Jeff D.; Rambo, Neil H.

2015-01-01

Question/Purpose The New York University (NYU) Health Sciences Library used a new method to arrange in-depth discussions with basic science researchers. The objective was to identify collaborators for a new National Library of Medicine administrative supplement. Setting The research took place at the NYU Health Sciences Library. Methods Using the National Institutes of Health (NIH) RePORTER, forty-four researchers were identified and later contacted through individualized emails. Results Nine researchers responded to the email followed by six in-person or phone discussions. At the conclusion of this process, two researchers submitted applications for supplemental funding, and both of these applications were successful. Conclusions This method confirmed these users could benefit from the skills and knowledge of health sciences librarians, but they are largely unaware of this. PMID:26213507

The Basic Epistemological Questions--Are There Also Valid Answers?

ERIC Educational Resources Information Center

Oderman, Dale B.

Epistemology is the branch of philosophy that seeks answers to two main questions: How do we know? and How do we know we know? This paper is concerned with how four major schools of thought have addressed these questions and the implications that their answers to these questions have for education. The paper begins by discussing how four major…

The American Indians: Answers to 101 Questions.

ERIC Educational Resources Information Center

Bureau of Indian Affairs (Dept. of Interior), Washington, DC.

Presented in a simple and straightforward manner, this publication answers questions basic to an understanding of the American Indian and his socioeconomic position in the United States. The following identify major areas covered and representative questions: (1) The Indian People (Who is an Indian?); (2) The Legal Status of Indians (Are Indians…

Intellectual and Physical Disabilities in Prehistory and Early Civilization

ERIC Educational Resources Information Center

Berkson, Gershon

2004-01-01

This paper is focused on three basic questions: The first concerns when specific disabilities first appeared during human evolution. The second question has to do with causes of disabilities. The third question concerns social responses to people with disabilities. Discussions on each of the issues are presented.

Human Brains Engaged in Rat Brains: Student-driven Neuroanatomy Research in an Introductory Biology Lab Course.

PubMed

Gardner, Stephanie M; Adedokun, Omolola A; Weaver, Gabriela C; Bartlett, Edward L

2011-01-01

Inquiry-based laboratory instruction has been shown to actively engage students in the content and skills being taught. These courses are further intended to teach students not only what is known, but also the process by which investigators come to know it. We sought to take this approach one step further and incorporate novel research questions into an inquiry-based laboratory model early in the undergraduate course of study. In this research-based introductory laboratory course, first-year students acquired basic lab skills not just for their own sake, but rather within the context of a research question of a member of the faculty. Student projects investigated potential neuroanatomical changes in animal models of dyslexia and aging and included measurements of neuron numbers and levels and distribution of neuronal proteins. Students played an active role in designing and implementing an experimental plan, explored data analysis techniques, and reflected on the results that they obtained in scholarly forms such as research papers and a departmental poster session. Student feedback on this approach has been extremely positive, and the data collected were research quality preliminary data that are being actively pursued for further study. Based on our encouraging experiences, we conclude that designing an introductory course around novel research, including some assessments modeled after scholarly practices, provides motivation and excitement for the students, instills good scientific habits, and can potentially benefit departmental research.

Ethnic Differences and Motivation Based on Maslow’s Theory on Iranian Employees

PubMed Central

MOUSAVI, Seyed Hadi; DARGAHI, Hossein

2013-01-01

Background The aim of this study was to assess the levels of Maslow’s hierarchy of needs theory had been fulfilled and to compare the Maslow’s hierarchy of needs among Iranian different ethnic groups at Tehran University of Medical Sciences (TUMS). Methods: This research was a descriptive-analytical study which conducted among administrative employees of Tehran University of Medical Sciences; Tehran, Iran. The structured questionnaire consisted of 20 questions and demographic details. Each question had 4 parts to measure Maslow’s hierarchy of needs. The questionnaire was distributed randomly among 133 employees to fill-up the demographic details and the other questions. Data was collected and analyzed by SPSS software, and One Way ANOVA, T-test, Spearman and Mann Whitney statistical methods. Results: TUMS ethnic groups of the employees placed most importance on Basic, Self-esteem and Self-actualization. In addition, we found that Persians, Mazandaranians, and Turks ethnic groups, scored the most mean for Maslow’s hierarchical needs compared to the other ethnic groups. Conclusion: Basic needs and safety needs is available amongst the different ethnic groups in Iran. As though, self-actualization needs are ultimate human goal, Iranian employees’ ethnic groups pay emphasis on these needs. We believe that new structures and work practices such as prevailing cultural values and beliefs of the society or the organizations must be explored if Iranian-based organizations want to remain responsive to the needs of the workplace. PMID:23802110

Critical Review of Technical Questions Facing Low Impact Development and Green Infrastructure: A Perspective from the Great Plains.

PubMed

Vogel, Jason R; Moore, Trisha L; Coffman, Reid R; Rodie, Steven N; Hutchinson, Stacy L; McDonough, Kelsey R; McLemore, Alex J; McMaine, John T

2015-09-01

Since its inception, Low Impact Development (LID) has become part of urban stormwater management across the United States, marking progress in the gradual transition from centralized to distributed runoff management infrastructure. The ultimate goal of LID is full, cost-effective implementation to maximize watershed-scale ecosystem services and enhance resilience. To reach that goal in the Great Plains, the multi-disciplinary author team presents this critical review based on thirteen technical questions within the context of regional climate and socioeconomics across increasing complexities in scale and function. Although some progress has been made, much remains to be done including continued basic and applied research, development of local LID design specifications, local demonstrations, and identifying funding mechanisms for these solutions. Within the Great Plains and beyond, by addressing these technical questions within a local context, the goal of widespread acceptance of LID can be achieved, resulting in more effective and resilient stormwater management.

Abortion politics and the production of knowledge.

PubMed

Harris, Lisa H

2013-08-01

It is common to think of scientific research and the knowledge it generates as neutral and value free. Indeed, the scientific method is designed to produce "objective" data. However, there are always values built into science, as historians of science and technology have shown over and over. The relevant question is not how to rid science of values but, instead, to ask which values and whose values belong? Currently, antiabortion values consistently determine US research policy. Abortion research is declared illegitimate in covert and overt ways, at the level of individual researchers and research policy broadly. Most importantly, federal policy impedes conduct of both basic and clinical research in abortion. However, it is not just research in abortion that is deemed "illegitimate;" research in infertility and in vitro fertilization is as well. Federal funding of any reproductive health research agenda that would pose more than minimal risk to a fetus or embryo is banned. This leaves unanswered scientific questions about abortion, infertility, miscarriage and contraception among other areas. Since moral ground is occupied not just by abortion opponents but also by people who support abortion rights, there is at the very least a competing moral claim to consider changing federal research funding policy. Women and families deserve access to knowledge across the spectrum of reproductive health issues, whether they seek to end or start a pregnancy. Thus, research funding is an issue of reproductive justice. Copyright © 2013 Elsevier Inc. All rights reserved.

Meeting Basic Learning Needs through Programmes of Early Childhood Care and Development.

ERIC Educational Resources Information Center

Consultative Group on Early Childhood Care and Development, Haydenville, MA.

Noting that early childhood development is the foundation for basic education across the life span, the first chapter of this report discusses the benefits of early interventions for individuals and society and justifies the basis for programs which aim at meeting the basic learning needs of young children. It also suggests several questions which…

The Alpha Mu Study: A Report on the Survey of Basic Business Survival Skills.

ERIC Educational Resources Information Center

Whitney, Eugene P.

A study was conducted to secure information relating to the following questions: (1) Are high school graduates leaving school with sufficient basic business skills to adequately manage their personal business affairs? and (2) what role is the business education department playing to provide all students with these basic business skills? A list of…

[Concept and results of the German Research Network on Schizophrenia].

PubMed

Gaebel, W; Buchkremer, G; Häfner, H; Klosterkötter, J; Maier, W; Möller, H-J; Wölwer, W

2016-04-01

The German Research Network on Schizophrenia (GRNS) was funded by the Federal Ministry of Education and Research (BMBF) from 1999 to 2011. The aim was to obtain a better horizontal and vertical networking of German research and care facilities on schizophrenia, in order to investigate open research questions, to transfer the results into clinical practice and improve care and quality of life in patients with schizophrenia. This paper describes the concept and operations of the GRNS as well as its results on the basis of selected research projects. The GRNS comprised about 25 clinical trials of high practical relevance, which were closely interrelated regarding content, methodology and organization. The trials primarily served the development and evaluation of new and established diagnostic and therapeutic approaches, the assessment of the status quo of clinical care, as well as its improvements, together with the investigation of basic scientific questions. Many substantial results to highly relevant issues were obtained, which led or will lead to an improvement in mental health care. Quantitative and qualitative evaluation parameters, such as scientific publications and obtaining additional grants, as well as promotion of young scientists, public relations activities, congress activities and the foundation of a European Schizophrenia Association, document the successful work of the network. Successful funding requests will allow us to continue cooperative schizophrenia research in Germany as initiated by the GRNS, without necessarily always binding these activities formally to the GRNS.

Governing boards and profound organizational change in hospitals.

PubMed

Fennell, M L; Alexander, J A

1989-01-01

Over the past decade the importance of governing boards as policy-making setting and oversight units within organizations has increased dramatically. Although this is true for both corporate- and private-sector organizations (Bacon and Brown 1977; Gelman 1988), it is particularly relevant to the health sector. Hospital governing boards, long considered inconsequential in hospital management, have recently become subject to closer scrutiny. The role of governing boards in decisions affecting hospital strategy and hospital performance is once again a topic of some interest in boardrooms and hospital trade journals. Impressive evidence of the renewed interest in governance is provided by the funding of an instructional consortium by the S.K. Kellogg Foundation to help strengthen trusteeship and governing board decision making, and to improve education for health services managers in the area of governance. Members of the consortium include the Hospital Research and Educational Trust, the American Hospital Association, the American College of Healthcare Executives, and the Association for University Programs in Health Administration. Among the activities being undertaken by this consortium is the development of a self-assessment tool/methodology for boards, a bibliography and reference guide on effective governance for practicing trustees, research workshops for faculty in health administration programs, and a teaching guide on governance and trustee leadership. Despite this interest, the question with which we began this article persists. Do governing boards make a difference? In the course of our review of previous work on governance we found that, more often than not, that question has been transformed into: how do boards influence hospital performance? And very often that question has been further narrowed into: which board structure leads to better hospital performance? We have argued for a respecification of the initial question. Rather than pursuing a definition of the maximally performing governing board, we should perhaps shift our focus back to a fuller understanding of board structure and function, and its influence on hospital change. The model developed here combines four essential, and very basic, questions: 1. What are the basic dimensions that underlie structural variation in different types of governing boards? 2. How do these board types influence structural change in hospitals? 3. How is the effect of board influence on change itself likely to change over time as a function of the hospital's general pattern of growth, decline, stability, or instability?(ABSTRACT TRUNCATED AT 400 WORDS)

Breastfeeding-Basics

Cancer.gov

Breastfeeding is a great way to give your baby a healthy start. Here we cover some of the most common questions new moms have. There are also people in your community who can answer other, more specific questions you may have.

[Tracking study to improve basic academic ability in chemistry for freshmen].

PubMed

Sato, Atsuko; Morone, Mieko; Azuma, Yutaka

2010-08-01

The aims of this study were to assess the basic academic ability of freshmen with regard to chemistry and implement suitable educational guidance measures. At Tohoku Pharmaceutical University, basic academic ability examinations are conducted in chemistry for freshmen immediately after entrance into the college. From 2003 to 2009, the examination was conducted using the same questions, and the secular changes in the mean percentage of correct response were statistically analyzed. An experience survey was also conducted on 2007 and 2009 freshmen regarding chemical experiments at senior high school. Analysis of the basic academic ability examinations revealed a significant decrease in the mean percentage of correct responses after 2007. With regard to the answers for each question, there was a significant decrease in the percentage of correct answers for approximately 80% of questions. In particular, a marked decrease was observed for calculation questions involving percentages. A significant decrease was also observed in the number of students who had experiences with chemical experiments in high school. However, notable results have been achieved through the implementation of practice incorporating calculation problems in order to improve calculation ability. Learning of chemistry and a lack of experimental experience in high school may be contributory factors in the decrease in chemistry academic ability. In consideration of the professional ability demanded of pharmacists, the decrease in calculation ability should be regarded as a serious issue and suitable measures for improving calculation ability are urgently required.

Keys to Success: School Facilities Primer, Questions & Answers 101.

ERIC Educational Resources Information Center

Brady, Jim

This publication provides answers to basic questions to help school board members more fully address the complexities of the planning, design, and construction process in order to maximize the goal of student success. The 101 questions and answers are in the areas of: facility planning; learning environment; information technology; safe schools;…

Strengthening research capacity through the medical education partnership initiative: the Mozambique experience

PubMed Central

2013-01-01

Background Since Mozambique’s independence, the major emphasis of its higher educational institutions has been on didactic education. Because of fiscal and human resource constraints, basic and applied research activities have been relatively modest in scope, and priorities have often been set primarily by external collaborators. These factors have compromised the scope and the relevance of locally conducted research and have limited the impact of Mozambique’s universities as major catalysts for national development. Case description We developed a multi-institutional partnership to undertake a comprehensive analysis of the research environment at Mozambique’s major public universities to identify factors that have served as barriers to the development of a robust research enterprise. Based on this analysis, we developed a multifaceted plan to reduce the impact of these barriers and to enhance research capacity within Mozambique. Interventions On the basis of our needs assessment, we have implemented a number of major initiatives within participating institutions to facilitate basic and applied research activities. These have included specialized training programmes, a reorganization of the research administration infrastructure, the development of multiple collaborative research projects that have emphasized local research priorities and a substantial investment in bioinformatics. We have established a research support centre that provides grant development and management services to Mozambique’s public universities and have developed an independent Institutional Review Board for the review of research involving human research subjects. Multiple research projects involving both communicable and non-communicable diseases have been developed and substantial external research support has been obtained to undertake these projects. A sizable investment in biomedical informatics has enhanced both connectivity and access to digital reference material. Active engagement with relevant entities within the Government of Mozambique has aligned institutional development with national priorities. Conclusions Although multiple challenges remain, over the past 3 years significant progress has been made towards establishing conditions within which a broad range of basic, translational and clinical and public health research can be undertaken. Ongoing development of this research enterprise will enhance capacity to address critical locally relevant research questions and will leverage resources to accelerate the development of Mozambique’s national universities. PMID:24304706

Feminism and psychology: analysis of a half-century of research on women and gender.

PubMed

Eagly, Alice H; Eaton, Asia; Rose, Suzanna M; Riger, Stephanie; McHugh, Maureen C

2012-04-01

Starting in the 1960s, feminists argued that the discipline of psychology had neglected the study of women and gender and misrepresented women in its research and theories. Feminists also posed many questions worthy of being addressed by psychological science. This call for research preceded the emergence of a new and influential body of research on gender and women that grew especially rapidly during the period of greatest feminist activism. The descriptions of this research presented in this article derive from searches of the journal articles cataloged by PsycINFO for 1960-2009. These explorations revealed (a) a concentration of studies in basic research areas investigating social behavior and individual dispositions and in many applied areas, (b) differing trajectories of research on prototypical topics, and (c) diverse theoretical orientations that authors have not typically labeled as feminist. The considerable dissemination of this research is evident in its dispersion beyond gender-specialty journals into a wide range of other journals, including psychology's core review and theory journals, as well as in its coverage in introductory psychology textbooks. In this formidable body of research, psychological science has reflected the profound changes in the status of women during the last half-century and addressed numerous questions that these changes have posed. Feminism served to catalyze this research area, which grew beyond the bounds of feminist psychology to incorporate a very large array of theories, methods, and topics.

Political legitimacy and approval of political protest and violence among children and adolescents.

PubMed

Funderburk, C

1975-06-01

A question of general theoretical relevance for political socialization research concerns the role played by basic political orientations in structuring specific political opinions. This report investigates the relationship between beliefs in the legitimacy of political objects and approval of political protest and violence among a sample of children and adolescents. The setting for the research was a Florida town. Four aspects of political legitimacy are defined and measured. Measures of approval of political protest and political violence are distinguished conceptually and empirically. Beliefs in political legitimacy are shown to be of considerable importance in structuring opinions about political violence but have little impact on opinions about protest.

Mechanistic systems modeling to guide drug discovery and development

PubMed Central

Schmidt, Brian J.; Papin, Jason A.; Musante, Cynthia J.

2013-01-01

A crucial question that must be addressed in the drug development process is whether the proposed therapeutic target will yield the desired effect in the clinical population. Pharmaceutical and biotechnology companies place a large investment on research and development, long before confirmatory data are available from human trials. Basic science has greatly expanded the computable knowledge of disease processes, both through the generation of large omics data sets and a compendium of studies assessing cellular and systemic responses to physiologic and pathophysiologic stimuli. Given inherent uncertainties in drug development, mechanistic systems models can better inform target selection and the decision process for advancing compounds through preclinical and clinical research. PMID:22999913

Mechanistic systems modeling to guide drug discovery and development.

PubMed

Schmidt, Brian J; Papin, Jason A; Musante, Cynthia J

2013-02-01

A crucial question that must be addressed in the drug development process is whether the proposed therapeutic target will yield the desired effect in the clinical population. Pharmaceutical and biotechnology companies place a large investment on research and development, long before confirmatory data are available from human trials. Basic science has greatly expanded the computable knowledge of disease processes, both through the generation of large omics data sets and a compendium of studies assessing cellular and systemic responses to physiologic and pathophysiologic stimuli. Given inherent uncertainties in drug development, mechanistic systems models can better inform target selection and the decision process for advancing compounds through preclinical and clinical research. Copyright © 2012 Elsevier Ltd. All rights reserved.

Science ethics education: effects of a short lecture on plagiarism on the knowledge of young medical researchers.

PubMed

Brkic, S; Bogdanovic, G; Vuckovic-Dekic, Lj; Gavrilovic, D; Kezic, I

2012-01-01

Plagiarism is the most common form of scientific fraud. It is agreed that the best preventive measure is education of young scientists on basic principles of responsible conduct of research and writing. The purpose of this article was to contribute to the students' knowledge and adoption of the rules of scientific writing. A 45 min lecture was delivered to 98 attendees during 3 courses on science ethics. Before and after the course the attendees fulfilled an especially designed questionnaire with 13 questions, specifically related to the definition and various types of plagiarism and self-plagiarism. Although considering themselves as insufficiently educated in science ethics, the majority of the attendees responded correctly to almost all questions even before the course, with percentages of correct responses to the specific question varying from 45.9-85.7%. After completion of the course, these percentages were significantly (p<0.01) higher, ranging from 66.3-98.8%. The percentage of improvement of the knowledge about plagiarism ranged from 9.18- 42.86%. The percentage of impairment ranged from 1.02- 16.33%, the latter being related to the question on correct citing unpublished materials of other people; only for this question the percentage of impairment (16.33%) was greater than the percentage of improvement (11.22%). Even a short lecture focused on plagiarism contributed to the students' awareness that there are many forms of plagiarism, and that plagiarism is a serious violation of science ethics. This result confirms the largely accepted opinion that education is the best means in preventing plagiarism.

The Event Related Brain Potential as an Index of Information Processing, Cognitive Activity, and Skill Acquisition: A Program of Basic Research.

DTIC Science & Technology

1985-02-28

psychophysiological function in question. For example, for most measurements of the cardiovascular system, data are available only at each heart beat ...function of the duration of the charging period, *i . and hence will be proportional to the inter- beat interval (and inversely °°. • .*~* 14 information (0... beat interval. Thus, the output will lag the input. 2.3 Computer Access to Voltage x Time Functions 2.3.1 Digital Input and Analog-to-Digital Conversion

Update on the genomics and basic biology of Brachypodium: International Brachypodium Initiative (IBI).

PubMed

Catalan, Pilar; Chalhoub, Boulos; Chochois, Vincent; Garvin, David F; Hasterok, Robert; Manzaneda, Antonio J; Mur, Luis A J; Pecchioni, Nicola; Rasmussen, Søren K; Vogel, John P; Voxeur, Aline

2014-07-01

The scientific presentations at the First International Brachypodium Conference (abstracts available at http://www.brachy2013.unimore.it) are evidence of the widespread adoption of Brachypodium distachyon as a model system. Furthermore, the wide range of topics presented (genome evolution, roots, abiotic and biotic stress, comparative genomics, natural diversity, and cell walls) demonstrates that the Brachypodium research community has achieved a critical mass of tools and has transitioned from resource development to addressing biological questions, particularly those unique to grasses. Copyright © 2014 Elsevier Ltd. All rights reserved.

An Algebraic Approach to the Study and Optimization of the Set of Rules of a Conditional Rewrite System

NASA Astrophysics Data System (ADS)

Makhortov, S. D.

2018-03-01

An algebraic system containing the semantics of a set of rules of the conditional equational theory (or the conditional term rewriting system) is introduced. The following basic questions are considered for the given model: existence of logical closure, structure of logical closure, possibility of equivalent transformations, and construction of logical reduction. The obtained results can be applied to the analysis and automatic optimization of the corresponding set of rules. The basis for the given research is the theory of lattices and binary relations.

Seizures and Epilepsy: An Overview for Neuroscientists

PubMed Central

Stafstrom, Carl E.; Carmant, Lionel

2015-01-01

Epilepsy is one of the most common and disabling neurologic conditions, yet we have an incomplete understanding of the detailed pathophysiology and, thus, treatment rationale for much of epilepsy. This article reviews the clinical aspects of seizures and epilepsy with the goal of providing neuroscientists an introduction to aspects that might be amenable to scientific investigation. Seizures and epilepsy are defined, diagnostic methods are reviewed, various clinical syndromes are discussed, and aspects of differential diagnosis, treatment, and prognosis are considered to enable neuroscientists to formulate basic and translational research questions. PMID:26033084

Methodology Series Module 9: Designing Questionnaires and Clinical Record Forms - Part II.

PubMed

Setia, Maninder Singh

2017-01-01

This article is a continuation of the previous module on designing questionnaires and clinical record form in which we have discussed some basic points about designing the questionnaire and clinical record forms. In this section, we will discuss the reliability and validity of questionnaires. The different types of validity are face validity, content validity, criterion validity, and construct validity. The different types of reliability are test-retest reliability, inter-rater reliability, and intra-rater reliability. Some of these parameters are assessed by subject area experts. However, statistical tests should be used for evaluation of other parameters. Once the questionnaire has been designed, the researcher should pilot test the questionnaire. The items in the questionnaire should be changed based on the feedback from the pilot study participants and the researcher's experience. After the basic structure of the questionnaire has been finalized, the researcher should assess the validity and reliability of the questionnaire or the scale. If an existing standard questionnaire is translated in the local language, the researcher should assess the reliability and validity of the translated questionnaire, and these values should be presented in the manuscript. The decision to use a self- or interviewer-administered, paper- or computer-based questionnaire depends on the nature of the questions, literacy levels of the target population, and resources.

Methodology Series Module 9: Designing Questionnaires and Clinical Record Forms – Part II

PubMed Central

Setia, Maninder Singh

2017-01-01

This article is a continuation of the previous module on designing questionnaires and clinical record form in which we have discussed some basic points about designing the questionnaire and clinical record forms. In this section, we will discuss the reliability and validity of questionnaires. The different types of validity are face validity, content validity, criterion validity, and construct validity. The different types of reliability are test-retest reliability, inter-rater reliability, and intra-rater reliability. Some of these parameters are assessed by subject area experts. However, statistical tests should be used for evaluation of other parameters. Once the questionnaire has been designed, the researcher should pilot test the questionnaire. The items in the questionnaire should be changed based on the feedback from the pilot study participants and the researcher's experience. After the basic structure of the questionnaire has been finalized, the researcher should assess the validity and reliability of the questionnaire or the scale. If an existing standard questionnaire is translated in the local language, the researcher should assess the reliability and validity of the translated questionnaire, and these values should be presented in the manuscript. The decision to use a self- or interviewer-administered, paper- or computer-based questionnaire depends on the nature of the questions, literacy levels of the target population, and resources. PMID:28584367

Biliary atresia and other cholestatic childhood diseases: Advances and future challenges.

PubMed

Verkade, Henkjan J; Bezerra, Jorge A; Davenport, Mark; Schreiber, Richard A; Mieli-Vergani, Georgina; Hulscher, Jan B; Sokol, Ronald J; Kelly, Deirdre A; Ure, Benno; Whitington, Peter F; Samyn, Marianne; Petersen, Claus

2016-09-01

Biliary Atresia and other cholestatic childhood diseases are rare conditions affecting the function and/or anatomy along the canalicular-bile duct continuum, characterised by onset of persistent cholestatic jaundice during the neonatal period. Biliary atresia (BA) is the most common among these, but still has an incidence of only 1 in 10-19,000 in Europe and North America. Other diseases such as the genetic conditions, Alagille syndrome (ALGS) and Progressive Familial Intrahepatic Cholestasis (PFIC), are less common. Choledochal malformations are amenable to surgical correction and require a high index of suspicion. The low incidence of such diseases hinder patient-based studies that include large cohorts, while the limited numbers of animal models of disease that recapitulate the spectrum of disease phenotypes hinders both basic research and the development of new treatments. Despite their individual rarity, collectively BA and other cholestatic childhood diseases are the commonest indications for liver transplantation during childhood. Here, we review the recent advances in basic research and clinical progress in these diseases, as well as the research needs. For the various diseases, we formulate current key questions and controversies and identify top priorities to guide future research. Copyright © 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

Public Awareness Survey Recommendations of the NHTSA-GHSA Working Group

DOT National Transportation Integrated Search

2011-07-01

The Governors Highway Safety Association (GHSA) and the National Highway Traffic Safety Administration (NHTSA) developed a basic set of survey questions including information on seat belt use, impaired driving, and speeding. These core questions can ...

Preparing future teachers to anticipate student difficulties in physics in a graduate-level course in physics, pedagogy, and education research

NASA Astrophysics Data System (ADS)

Thompson, John R.; Christensen, Warren M.; Wittmann, Michael C.

2011-06-01

We describe courses designed to help future teachers reflect on and discuss both physics content and student knowledge thereof. We use three kinds of activities: reading and discussing the literature, experiencing research-based curricular materials, and learning to use the basic research methods of physics education research. We present a general overview of the two courses we have designed as well as a framework for assessing student performance on physics content knowledge and one aspect of pedagogical content knowledge—knowledge of student ideas—about one particular content area: electric circuits. We find that the quality of future teachers’ responses, especially on questions dealing with knowledge of student ideas, can be successfully categorized and may be higher for those with a nonphysics background than those with a physics background.

Research priorities to reduce the global burden of dementia by 2025.

PubMed

Shah, Hiral; Albanese, Emiliano; Duggan, Cynthia; Rudan, Igor; Langa, Kenneth M; Carrillo, Maria C; Chan, Kit Yee; Joanette, Yves; Prince, Martin; Rossor, Martin; Saxena, Shekhar; Snyder, Heather M; Sperling, Reisa; Varghese, Mathew; Wang, Huali; Wortmann, Marc; Dua, Tarun

2016-11-01

At the First WHO Ministerial Conference on Global Action Against Dementia in March, 2015, 160 delegates, including representatives from 80 WHO Member States and four UN agencies, agreed on a call for action to reduce the global burden of dementia by fostering a collective effort to advance research. To drive this effort, we completed a globally representative research prioritisation exercise using an adapted version of the Child Health and Nutrition Research Initiative method. We elicited 863 research questions from 201 participants and consolidated these questions into 59 thematic research avenues, which were scored anonymously by 162 researchers and stakeholders from 39 countries according to five criteria. Six of the top ten research priorities were focused on prevention, identification, and reduction of dementia risk, and on delivery and quality of care for people with dementia and their carers. Other priorities related to diagnosis, biomarkers, treatment development, basic research into disease mechanisms, and public awareness and understanding of dementia. Research priorities identified by this systematic international process should be mapped onto the global dementia research landscape to identify crucial gaps and inform and motivate policy makers, funders, and researchers to support and conduct research to reduce the global burden of dementia. Efforts are needed by all stakeholders, including WHO, WHO Member States, and civil society, to continuously monitor research investments and progress, through international platforms such as a Global Dementia Observatory. With established research priorities, an opportunity now exists to translate the call for action into a global dementia action plan to reduce the global burden of dementia. Copyright © 2016 Elsevier Ltd. All rights reserved.

Adult Basic Education and Self-Esteem: Practical Strategies for Addressing Self-Esteem Problems among Basic Skills Students.

ERIC Educational Resources Information Center

Kirstein, Kurt D.

The strategies used by practicing adult basic education (ABE) teachers to retain students with poor self-esteem were examined through an Internet survey that was sent to 115 ABE instructors at community colleges in Washington. The survey, which contained questions about the prevalence of poor self-esteem among ABE dropouts, specific behaviors…

An Introductory "How-to" Guide for Incorporating Microbiome Research into Integrative and Comparative Biology.

PubMed

Kohl, Kevin D

2017-10-01

Research on host-associated microbial communities has grown rapidly. Despite the great body of work, inclusion of microbiota-related questions into integrative and comparative biology is still lagging behind other disciplines. The purpose of this paper is to offer an introduction into the basic tools and techniques of host-microbe research. Specifically, what considerations should be made before embarking on such projects (types of samples, types of controls)? How is microbiome data analyzed and integrated with data measured from the hosts? How can researchers experimentally manipulate the microbiome? With this information, integrative and comparative biologists should be able to include host-microbe studies into their research and push the boundaries of both fields. © The Author 2017. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

Being a Scientist While Teaching Science: Implementing Undergraduate Research Opportunities for Elementary Educators

NASA Astrophysics Data System (ADS)

Hock, Emily; Sharp, Zoe

2016-03-01

Aspiring teachers and current teachers can gain insight about the scientific community through hands-on experience. As America's standards for elementary school and middle school become more advanced, future and current teachers must gain hands-on experience in the scientific community. For a teacher to be fully capable of teaching all subjects, they must be comfortable in the content areas, equipped to answer questions, and able to pass on their knowledge. Hands-on research experiences, like the Summer Astronomy Research Experience at California Polytechnic University, pair liberal studies students with a cooperative group of science students and instructors with the goal of doing research that benefits the scientific community and deepens the team members' perception of the scientific community. Teachers are then able to apply the basic research process in their classrooms, inspire students to do real life science, and understand the processes scientists' undergo in their workplace.

Climate Change: On Scientists and Advocacy

NASA Technical Reports Server (NTRS)

Schmidt, Gavin A.

2014-01-01

Last year, I asked a crowd of a few hundred geoscientists from around the world what positions related to climate science and policy they would be comfortable publicly advocating. I presented a list of recommendations that included increased research funding, greater resources for education, and specific emission reduction technologies. In almost every case, a majority of the audience felt comfortable arguing for them. The only clear exceptions were related to geo-engineering research and nuclear power. I had queried the researchers because the relationship between science and advocacy is marked by many assumptions and little clarity. This despite the fact that the basic question of how scientists can be responsible advocates on issues related to their expertise has been discussed for decades most notably in the case of climate change by the late Stephen Schneider.

Toward functional classification of neuronal types.

PubMed

Sharpee, Tatyana O

2014-09-17

How many types of neurons are there in the brain? This basic neuroscience question remains unsettled despite many decades of research. Classification schemes have been proposed based on anatomical, electrophysiological, or molecular properties. However, different schemes do not always agree with each other. This raises the question of whether one can classify neurons based on their function directly. For example, among sensory neurons, can a classification scheme be devised that is based on their role in encoding sensory stimuli? Here, theoretical arguments are outlined for how this can be achieved using information theory by looking at optimal numbers of cell types and paying attention to two key properties: correlations between inputs and noise in neural responses. This theoretical framework could help to map the hierarchical tree relating different neuronal classes within and across species. Copyright © 2014 Elsevier Inc. All rights reserved.

Altered DNA methylation: a secondary mechanism involved in carcinogenesis.

PubMed

Goodman, Jay I; Watson, Rebecca E

2002-01-01

This review focuses on the role that DNA methylation plays in the regulation of normal and aberrant gene expression and on how, in a hypothesis-driven fashion, altered DNA methylation may be viewed as a secondary mechanism involved in carcinogenesis. Research aimed at discerning the mechanisms by which chemicals can transform normal cells into frank carcinomas has both theoretical and practical implications. Through an increased understanding of the mechanisms by which chemicals affect the carcinogenic process, we learn more about basic biology while, at the same time, providing the type of information required to make more rational safety assessment decisions concerning their actual potential to cause cancer under particular conditions of exposure. One key question is: does the mechanism of action of the chemical in question involve a secondary mechanism and, if so, what dose may be below its threshold?

Teaching Research Skills to Student Pharmacists in One Semester: An Applied Research Elective.

PubMed

Perez, Alexandra; Rabionet, Silvia; Bleidt, Barry

2017-02-25

Objectives. To implement and assess the effectiveness of a 15-week applied research elective that introduced students to secondary database analysis in clinical pharmacy. Design. In small groups, students learned, planned, developed and completed a secondary database study to answer an original research question. During one semester, they completed a basic research proposal and Institutional Review Board application, created and analyzed a National Health and Nutrition Examination Survey (NHANES) sample dataset, and reported the results in an abstract and poster presentation. Assessment. All deliverables resulted in high grades. Mean scores on a survey conducted following completion of the course revealed that students strongly agreed or agreed that they had high levels of confidence about performing research-related tasks. Eight student groups delivered poster presentations at professional conferences. Conclusions. Within one semester, student pharmacists with no or little research experience completed original research projects that contributed to pharmacy practice knowledge. They felt highly confident doing research-related tasks, and successfully disseminated their studies beyond the classroom.

Analysis of Questions Used in the Teaching of Non-Narrative Poetry.

ERIC Educational Resources Information Center

McBride, William Gilbert

The purposes of this study were to analyze questions used in the teaching of non-narrative poetry and to ascertain whether it is possible to establish any generally useful, basic pattern of question asking that would provide the student some fundamental guidelines for the study of this type of literature. First, a detailed examination of Robert…

The Effects of Different Feedback Strategies Using Computer-Administered Multiple-Choice Questions as Instruction.

ERIC Educational Resources Information Center

Clariana, Roy B.; And Others

The present study investigated the effects of using different forms of material with 100 eleventh grade students enrolled in a 5-week CBI (computer based instruction) summer enrichment program in Memphis, Tennessee. The basic design consisted of two conditions of instructional support (text and questions vs. questions only), two testings…

Growth Impacts on Public Service Expenditures: Some Questions for the Community. Coping with Growth.

ERIC Educational Resources Information Center

Rimbey, Neil R.

Defining public services as the basic community/regional services which are provided to residents through tax receipts and service charges, this publication identifies variables for each service group and presents them in the form of questions that communities should find useful when analyzing impacts of growth. After listing questions dealing…

Five Years of NASA Research on ISS: A Continuing Saga

NASA Technical Reports Server (NTRS)

Uri, John J.

2005-01-01

The first NASA experiments reached ISS in September 2000, a very modest beginning to what later became a more robust, diverse and overall highly successful research program, continuing essentially uninterrupted since March 2001. Along the way, several major challenges had to be overcome. First, there were delays in the initial construction of the station. Second, maintenance of the station exceeded earlier assumptions resulting in less crew time being available for research. Third, the lengthy interruption of Shuttle flights after the Columbia accident significantly, but temporarily, reduced the research traffic to and from ISS. And fourth, the Vision of Space Exploration as caused a refocusing of NASA's research efforts on ISS from a multi-disciplinary basic and applied science program to one dedicated to solving the critical questions to enable exploration missions. The principal factors that allowed these challenges to be overcome have been flexibility and cooperation. Flexibility on the part of the ISS Program to minimize impacts to research from delays and resource bottlenecks, flexibility on the part of researchers to adapt their research to changing environments, and flexibility to be able to use existing and planned facilities not only for their original basic science purpose but also for new applications. And cooperation not only between the ISS Program and the research community, but also among NASA and its International Partners to continually strive to optimize the research conducted aboard ISS. Once the challenges were overcome, the research program has been remarkably successful, with an expanding on-orbit capability. Over 80 investigations have been completed, many resulting in publications.

What kind of memory has evolution wrought? Introductory article for the special issue of memory: adaptive memory: the emergence and nature of proximate mechanisms.

PubMed

Otgaar, Henry; Howe, Mark L

2014-01-01

It is without question that our memory system evolved through a process of natural selection. However, basic research into the evolutionary foundations of memory has begun in earnest only recently. This is quite peculiar as the majority, perhaps even all, of memory research relates to whether memory is adaptive or not. In this Special Issue of Memory we have assembled a variety of papers that represent the cutting edge in research on the evolution of memory. These papers are centred on issues about the ultimate and proximate explanations of memory, the development of the adaptive functions of memory, as well as the positive consequences that arise from the current evolutionary form that our memory has taken. In this introductory article we briefly outline these different areas and indicate why they are vital for a more complete theory of memory. Further we argue that, by adopting a more applied stance in the area of the evolution of memory, one of the many future directions in this field could be a new branch of psychology that addresses questions in evolutionary legal psychology.

Ludwig von Bertalanffy's Organismic View on the Theory of Evolution

PubMed Central

Drack, Manfred

2015-01-01

Ludwig von Bertalanffy was a key figure in the advancement of theoretical biology. His early considerations already led him to recognize the necessity of considering the organism as a system, as an organization of parts and processes. He termed the resulting research program organismic biology, which he extended to all basic questions of biology and almost all areas of biology, hence also to the theory of evolution. This article begins by outlining the rather unknown (because often written in German) research of Bertalanffy in the field of theoretical biology. The basics of the organismic approach are then described. This is followed by Bertalanffy's considerations on the theory of evolution, in which he used methods from theoretical biology and then introduced his own, organismic, view on evolution, leading to the demand for finding laws of evolution. Finally, his view on the concept of homology is presented. J. Exp. Zool. (Mol. Dev. Evol.) 324B: 77–90, 2015. © 2015 The Authors. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution published by Wiley Periodicals, Inc. PMID:25727202

Concepts of Dhatu Siddhanta (theory of tissues formation and differentiation) and Rasayana; probable predecessor of stem cell therapy.

PubMed

Sharma, Vinamra; Chaudhary, Anand Kumar

2014-01-01

To maintain health and to cure diseases through Rasayana (rejuvenation) therapy along with main treatment is the unique approach of Ayurveda. The basic constituent unit of a living being is always a functional cell. Question arises from where it is generated? How it attains its final specific differentiation form? As age progresses, various changes occur at every cell level and cell undergoes to adaptation accordingly. Microenvironment for cell nourishment diminishes with age or as disease condition persists. In this context, Acharyas had contributed and documented various facts and theories through their insight wisdom. Hidden secretes in the basic principles of any medical system are needed to be explained in terms of contemporary knowledge. Contemporary research areas should be opened to include various explanations of different fields of ancient thoughts to support these new doctrines, if any. This review may be helpful to open the door of future research area in the field of reverse scientific approach of Ayurveda in the context of Dhatu Siddhanta (theory of tissues formation and differentiation) and theory of stem cell.

Highlights of the advances in basic immunology in 2011.

PubMed

Liu, Juan; Liu, Shuxun; Cao, Xuetao

2012-05-01

In this review, we summarize the major fundamental advances in immunological research reported in 2011. The highlights focus on the improved understanding of key questions in basic immunology, including the initiation and activation of innate responses as well as mechanisms for the development and function of various T-cell subsets. The research includes the identification of novel cytosolic RNA and DNA sensors as well as the identification of the novel regulators of the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling pathway. Moreover, remarkable advances have been made in the developmental and functional properties of innate lymphoid cells (ILCs). Helper T cells and regulatory T (Treg) cells play indispensable roles in orchestrating adaptive immunity. There have been exciting discoveries regarding the regulatory mechanisms of the development of distinct T-cell subsets, particularly Th17 cells and Treg cells. The emerging roles of microRNAs (miRNAs) in T cell immunity are discussed, as is the recent identification of a novel T-cell subset referred to as follicular regulatory T (TFR) cells.

Highlights of the advances in basic immunology in 2011

PubMed Central

Liu, Juan; Liu, Shuxun; Cao, Xuetao

2012-01-01

In this review, we summarize the major fundamental advances in immunological research reported in 2011. The highlights focus on the improved understanding of key questions in basic immunology, including the initiation and activation of innate responses as well as mechanisms for the development and function of various T-cell subsets. The research includes the identification of novel cytosolic RNA and DNA sensors as well as the identification of the novel regulators of the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling pathway. Moreover, remarkable advances have been made in the developmental and functional properties of innate lymphoid cells (ILCs). Helper T cells and regulatory T (Treg) cells play indispensable roles in orchestrating adaptive immunity. There have been exciting discoveries regarding the regulatory mechanisms of the development of distinct T-cell subsets, particularly Th17 cells and Treg cells. The emerging roles of microRNAs (miRNAs) in T cell immunity are discussed, as is the recent identification of a novel T-cell subset referred to as follicular regulatory T (TFR) cells. PMID:22522654

[Empowerment in prevention and health promotion--a critical conceptual evaluation of basic understanding, dimensions and assessment problems].

PubMed

Kliche, T; Kröger, G

2008-12-01

Empowerment is an important concept in health care, but despite its prevalence it seems to be more of a buzz word. Thus, a conceptual review on empowerment in prevention and health promotion was carried out. 62 German and international theoretical contributions, reviews and studies were incorporated, covering the fields of prevention, care and therapy, rehabilitation, health-care research, nursing and work-related stress. The analysis revealed eight main dimensions of empowerment: (1) shared decision-making, (2) self-efficacy, (3) social support and social capital, (4) skills and competences, (5) health care utilisation, (6) goal setting and attainment, (7) reflexive thought and (8) innovation. Their empirical assessment can be carried out on a micro-, meso-, or macro-level. Three distinct basic conceptual notions emerged from the analysis, each applying its own specific research questions and measurement instruments: clinical, organizational-professional and political understanding of "empowerment". Therefore, these three specific conceptual notions should each be developed and tested separately, in particular in reviews, and empirical studies should embrace all eight subdimensions.

Colour thresholding and objective quantification in bioimaging

NASA Technical Reports Server (NTRS)

Fermin, C. D.; Gerber, M. A.; Torre-Bueno, J. R.

1992-01-01

Computer imaging is rapidly becoming an indispensable tool for the quantification of variables in research and medicine. Whilst its use in medicine has largely been limited to qualitative observations, imaging in applied basic sciences, medical research and biotechnology demands objective quantification of the variables in question. In black and white densitometry (0-256 levels of intensity) the separation of subtle differences between closely related hues from stains is sometimes very difficult. True-colour and real-time video microscopy analysis offer choices not previously available with monochrome systems. In this paper we demonstrate the usefulness of colour thresholding, which has so far proven indispensable for proper objective quantification of the products of histochemical reactions and/or subtle differences in tissue and cells. In addition, we provide interested, but untrained readers with basic information that may assist decisions regarding the most suitable set-up for a project under consideration. Data from projects in progress at Tulane are shown to illustrate the advantage of colour thresholding over monochrome densitometry and for objective quantification of subtle colour differences between experimental and control samples.

Concepts of Dhatu Siddhanta (theory of tissues formation and differentiation) and Rasayana; probable predecessor of stem cell therapy

PubMed Central

Sharma, Vinamra; Chaudhary, Anand Kumar

2014-01-01

To maintain health and to cure diseases through Rasayana (rejuvenation) therapy along with main treatment is the unique approach of Ayurveda. The basic constituent unit of a living being is always a functional cell. Question arises from where it is generated? How it attains its final specific differentiation form? As age progresses, various changes occur at every cell level and cell undergoes to adaptation accordingly. Microenvironment for cell nourishment diminishes with age or as disease condition persists. In this context, Acharyas had contributed and documented various facts and theories through their insight wisdom. Hidden secretes in the basic principles of any medical system are needed to be explained in terms of contemporary knowledge. Contemporary research areas should be opened to include various explanations of different fields of ancient thoughts to support these new doctrines, if any. This review may be helpful to open the door of future research area in the field of reverse scientific approach of Ayurveda in the context of Dhatu Siddhanta (theory of tissues formation and differentiation) and theory of stem cell. PMID:26664231

Neuroscience discipline science plan

NASA Technical Reports Server (NTRS)

1991-01-01

Over the past two decades, NASA's efforts in the neurosciences have developed into a program of research directed at understanding the acute changes that occur in the neurovestibular and sensorimotor systems during short-duration space missions. However, the proposed extended-duration flights of up to 28 days on the Shuttle orbiter and 6 months on Space Station Freedom, a lunar outpost, and Mars missions of perhaps 1-3 years in space, make it imperative that NASA's Life Sciences Division begin to concentrate research in the neurosciences on the chronic effects of exposure to microgravity on the nervous system. Major areas of research will be directed at understanding (1) central processing, (2) motor systems, (3) cognitive/spatial orientation, and (4) sensory receptors. The purpose of the Discipline Science Plan is to provide a conceptual strategy for NASA's Life Sciences Division research and development activities in the comprehensive area of neurosciences. It covers the significant research areas critical to NASA's programmatic requirements for the Extended-Duration Orbiter, Space Station Freedom, and exploration mission science activities. These science activities include ground-based and flight; basic, applied, and operational; and animal and human research and development. This document summarizes the current status of the program, outlines available knowledge, establishes goals and objectives, identifies science priorities, and defines critical questions in the subdiscipline areas of nervous system function. It contains a general plan that will be used by NASA Headquarters Program Offices and the field centers to review and plan basic, applied, and operational intramural and extramural research and development activities in this area.

From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases

PubMed Central

Czajkowski, Susan M.; Powell, Lynda H.; Adler, Nancy; Naar-King, Sylvie; Reynolds, Kim D.; Hunter, Christine M.; Laraia, Barbara; Olster, Deborah H.; Perna, Frank M.; Peterson, Janey C.; Epel, Elissa; Boyington, Josephine E.; Charlson, Mary E.

2015-01-01

Objective Given the critical role of behavior in preventing and treating chronic diseases, it is important to accelerate the development of behavioral treatments that can improve chronic disease prevention and outcomes. Findings from basic behavioral and social science research hold great promise for addressing behaviorally-based clinical health problems, yet there is currently no established pathway for translating fundamental behavioral science discoveries into health-related treatments ready for Phase III efficacy testing. This article provides a systematic framework for guiding efforts to translate basic behavioral science findings into behavioral treatments for preventing and treating chronic illness. Methods The ORBIT model for behavioral treatment development is described as involving a flexible and progressive process, pre-specified clinically significant milestones for forward movement, and return to earlier stages for refinement and optimization. Results This article presents the background and rationale for the ORBIT model, a summary of key questions for each phase, a selection of study designs and methodologies well-suited to answering these questions, and pre-specified milestones for forward or backward movement across phases. Conclusions The ORBIT model provides a progressive, clinically-relevant approach to increasing the number of evidence-based behavioral treatments available to prevent and treat chronic diseases. PMID:25642841

Human Brains Engaged in Rat Brains: Student-driven Neuroanatomy Research in an Introductory Biology Lab Course

PubMed Central

Gardner, Stephanie M.; Adedokun, Omolola A.; Weaver, Gabriela C.; Bartlett, Edward L.

2011-01-01

Inquiry-based laboratory instruction has been shown to actively engage students in the content and skills being taught. These courses are further intended to teach students not only what is known, but also the process by which investigators come to know it. We sought to take this approach one step further and incorporate novel research questions into an inquiry-based laboratory model early in the undergraduate course of study. In this research-based introductory laboratory course, first-year students acquired basic lab skills not just for their own sake, but rather within the context of a research question of a member of the faculty. Student projects investigated potential neuroanatomical changes in animal models of dyslexia and aging and included measurements of neuron numbers and levels and distribution of neuronal proteins. Students played an active role in designing and implementing an experimental plan, explored data analysis techniques, and reflected on the results that they obtained in scholarly forms such as research papers and a departmental poster session. Student feedback on this approach has been extremely positive, and the data collected were research quality preliminary data that are being actively pursued for further study. Based on our encouraging experiences, we conclude that designing an introductory course around novel research, including some assessments modeled after scholarly practices, provides motivation and excitement for the students, instills good scientific habits, and can potentially benefit departmental research. PMID:23626490

Using Astrobiology case studies to bring science decision making into the classroom: Mars sample return, exobiology and SETI

NASA Astrophysics Data System (ADS)

Race, Margaret

As citizens and decision makers of the future, today's students need to understand the nature of science and the implications of scientific discoveries and activities in a broad societal context. Astrobiology provides an opportunity to introduce students to real world decision-making involving cutting edge, multidisciplinary research topics that involve Earth, the solar system and beyond. Although textbooks and curricular materials may take years to develop, teachers can easily bring the latest astrobiological discoveries and hypotheses into the classroom in the form of case studies to complement science classes. For example, using basic biological, geological and chemical information from Earth and other planets, students can discuss the same questions that experts consider when planning a Mars Sample Return mission. How would you recognize extraterrestrial life? What would be the impact of bringing martian life to Earth? How should martian samples be handled and tested to determine whether they pose hazards to Earth's biota and ecosystems? If truly martian life exists, what are the implications for future human missions or colonies on the planet? What are the ethical and societal implications of discovering extraterrestrial life, whether in the solar system or beyond? What difference world it make if the extraterrestrial life is microbial and simple vs. intelligent and advanced? By integrating basic science concepts, up-to-date research findings, and information about laws, societal concerns, and public decision making, students can experience first-hand the kind of questions and challenges we're likely to face in the years ahead.

The NIE Conference on Basic Mathematical Skills and Learning (Euclid, Ohio, October 4-6, 1975). Volume I: Contributed Position Papers.

ERIC Educational Resources Information Center

National Inst. of Education (DHEW), Washington, DC.

In October 1975 a conference was convened in Euclid, Ohio, by the Basic Skills Group of the National Institute of Education (NIE). Thirty-three participants presented position papers addressing two major questions: (1) What are basic mathematical skills and learning? (2) What are the major problems related to children's acquisition of basic…

So, You Think You Have an Idea: A Practical Risk Reduction-Conceptual Model for Academic Translational Research

PubMed Central

Schwartz, John; Macomber, Christopher

2017-01-01

Translational research for new drugs, medical devices, and diagnostics encompasses aspects of both basic science and clinical research, requiring multidisciplinary skills and resources that are not all readily available in either a basic laboratory or clinical setting alone. We propose that, to be successful, “translational” research ought to be understood as a defined process from basic science through manufacturing, regulatory, clinical testing all the way to market. The authors outline a process which has worked well for them to identify and commercialize academic innovation. The academic environment places a high value on novelty and less value on whether, among other things, data are reproducible, scalable, reimbursable, or have commercial freedom to operate. In other words, when investors, strategic companies, or other later stage stakeholders evaluate academic efforts at translational research the relative lack of attention to clinical, regulatory, reimbursement, and manufacturing and intellectual property freedom to operate almost universally results in more questions and doubts about the potential of the proposed product, thereby inhibiting further interest. This contrasts with industry-based R&D, which often emphasizes manufacturing, regulatory and commercial factors. Academics do not so much choose to ignore those necessary and standard elements of translation development, but rather, they are not built into the culture or incentive structure of the university environment. Acknowledging and addressing this mismatch of approach and lack of common language in a systematic way facilitates a more effective “translation” handoffs of academic project concepts into meaningful clinical solutions help translational researchers more efficiently develop and progress new and better medical products which address validated needs. The authors provide an overview and framework for academic researchers to use which will help them define the elements of a market-driven translational program (1) problem identification and validation; (2) defining the conceptual model of disease; and (3) risk evaluation and mitigation strategies. PMID:28952508

Health communication: lessons from research.

PubMed

Shanmugam, A V

1981-01-01

In discussing the lessons learned from research in the area of health communication, focus is on basic strategic issues; the scope of health communications in terms of audience, information, education and motivation approaces and India's satellite Instructional Television Experiment (SITE). Health communication is the process by which a health idea is transferred from a source, such as a primary health center, to a receiver, community, with the intention of changing the community's behavior. This involves the formulation of specific strategies for the conduct of health and family welfare communication. In the processs of health communication, it has been a common practice in India as well as in other developing countries to depend upon a plethora of communication media. Yet, despite maximum utilization of the mass media and interpersonal channels of communication, questions remain about the efficacy of the system in bringing about change. Thus, the need to draw upon lessons from research becomes obvious. Communication effectiveness researches have concentrated on 3 basic strategic issues: the question of physical reception of messages by the audience; interpretation or understanding of messages on the part of the audience in accordance with the intention of the communicator; and effectiveness of communication on the cognitive, affective and behavioral dimensions of the audience. Innumberable researches in communication have provided several lessons which have expanded the scope of health communication. This expansion can be observed in terms of audiences reached, information disseminated, education undertaken, and motivation provided. Research has identified several distinct groups to whom specific health messages have to be addressed. These include government and political elites, health and family welfare program administrators, and the medical profession and clinical staff. Information on health needs to include both the concept of health and the pertinent ideas and facts about various health measures and available services. The innovative approach is more functional, and it tries to consider the values and attitudes of the audience that it hopes to reach. The health programs on SITE have been very well received by the rural audience in India according to several studies conducted by the various agencies.

Conceptual Astronomy Knowledge among Amateur Astronomers

NASA Astrophysics Data System (ADS)

Berendsen, Margaret L.

Amateur astronomers regularly serve as informal astronomy educators for their communities. This research inquires into the level of knowledge of basic astronomy concepts among amateur astronomers and examines factors related to amateur astronomy that affect that knowledge. Using the concept questions from the Astronomy Diagnostic Test Version 2, an online survey was developed as an assessment. In particular, astronomy club members with at least some college-level astronomy education score substantially higher on the assessment (mean score: 85) than do college undergraduates after taking their first astronomy course (mean score: 47). Astronomy club members scored up to 17% higher than unaffiliated amateurs, an indication that regular contact with like-minded hobbyists improves basic knowledge. Proportionally more astronomy club members report doing outreach than do unaffiliated amateurs (87% vs. 46%). It appears that those who are likely to be more knowledgeable are also those doing more outreach.

Basics of PD-1 in self-tolerance, infection, and cancer immunity.

PubMed

Chikuma, Shunsuke

2016-06-01

Successful cancer treatment requires understanding host immune response against tumor cells. PD-1 belongs to the CD28 superfamily of receptors that work as "checkpoints" of immune activation. PD-1 maintains immune self-tolerance to prevent autoimmunity and controls T-cell reaction during infection to prevent excessive tissue damage. Tumor cells that arise from normal tissue acquire mutations that can be targeted by lymphocytes. Accumulating lines of evidence suggest that tumor cells evade host immune attack by expressing physiological PD-1 ligands and stimulating PD-1 on the lymphocytes. Based on this idea, researchers have successfully demonstrated that systemic administration of monoclonal antibodies that inhibit the binding of PD-1 to the ligands reactivated T cells and augmented the anti-cancer immune response. In this review, I summarize the basics of T-cell biology and its regulation by PD-1 and discuss the current understanding and questions about this multifaceted molecule.

STEM integration in middle school career and technical education programs: A Delphi design study

NASA Astrophysics Data System (ADS)

Wu-Rorrer, Billy Ray

The purpose of this qualitative method study with a Delphi research design sought to determine how STEM programs can be effectively integrated into middle school career and technical education programs by local, state, and national educators, administrators, directors, specialists, and curriculum writers. The significance of the study is to provide leaders in CTE with a greater awareness, insight, and strategies about how CTE programs can more effectively integrate academics into career and technical education programs through STEM-related programming. The findings will increase the limited amount of available literature providing best practice strategies for the integration of STEM curriculum into middle school CTE programs. One basic question has guided this research: How can STEM programs be effectively integrated into middle school career and technical education programs? A total of twelve strategies were identified. The strategies of real-world applications and administrative buy-in were the two predominant strategies consistently addressed throughout the review of literature and all three sub-questions in the research study. The Delphi design study consisted of pilot round and three rounds of data collection on barriers, strategies, and professional development for STEM integration in middle school career and technical education programs. Four panelists participated in the pilot round, and 16 panel members not involved in the pilot round participated in the three rounds of questioning and consensus building. In the future, more comprehensive studies can build upon this foundational investigation of middle school CTE programs.

A meeting of minds: interdisciplinary research in the health sciences in Canada

PubMed Central

Hall, Judith G.; Bainbridge, Lesley; Buchan, Alison; Cribb, Alastair; Drummond, Jane; Gyles, Carlton; Hicks, T. Philip; McWilliam, Carol; Paterson, Barbara; Ratner, Pamela A.; Skarakis-Doyle, Elizabeth; Solomon, Patty

2006-01-01

Brought together by the newly formed Canadian Academy of Health Sciences (CAHS), recognized national leaders in the 6 health sciences disciplines consider the environment for conducting interdisciplinary health research (IDHR) in Canada. Based on first-hand knowledge and thoughtful reflection, the authors argue that although much progress has been made in support of IDHR in Canada, the practical experience of researchers does not always bear this out. This article examines government, industry and academia to identify the cultural and structural characteristics that demand, promote or prevent IDHR in each sector. At its heart is the question, How can universities best support and enhance IDHR, not only for the benefit of science, but also to meet the growing needs of industry and government for intellectual capital? Focusing on the predominant health sciences disciplines, the authors define IDHR as a team of researchers, solidly grounded in their respective disciplines, who come together around an important and challenging health issue, the research question for which is determined by a shared understanding in an interactive and iterative process. In addition, they suggest that IDHR is directly linked to translational research, which is the application of basic science to clinical practice and the generation of scientific questions through clinical observation. This analysis of academic, industry and government sectors is not intended to offer rigorous data on the current state of IDHR in Canada. Rather, the goal is to stimulate research-policy dialogue by suggesting a number of immediate measures that can help promote IDHR in Canada. Recommended measures to support IDHR are aimed at better resourcing and recognition (by universities and granting agencies), along with novel approaches to training, such as government- and industry-based studentships. In addition, we recommend that professional organizations reconsider their policies on publication and governance. Although intended to maintain professional scopes of practice, these policies also serve to entrench disciplinary boundaries in research. We conclude by suggesting a number of research questions for a more rigorous assessment of the climate for IDHR in Canada. We call for an inventory and comparative analysis of academic centres, institutes and consortiums in Canada that strive to facilitate IDHR; an examination of the impact of professional organizations on health research, and on IDHR in particular; and a systematic review of research training opportunities that promote IDHR, with a view to identifying and replicating proven models. PMID:17001059

HIV/AIDS Information Needs of Sexually Transmitted Infection Clinic Patients: Content Analysis of Questions Asked during Prevention Counseling

ERIC Educational Resources Information Center

Kalichman, Seth C.; Cain, Demetria; Knecht, Joanna; Hill, Justin

2008-01-01

Basic factual information about disease is the cornerstone of health promotion and disease prevention interventions. Previous studies have shown that content analysis of the questions asked of service providers can elucidate the information needs of service consumers. Questions asked by individuals at known high risk for HIV infection have not…

Initiatives in biological research in Indian psychiatry

PubMed Central

Shrivatava, Amresh

2010-01-01

Biological psychiatry is an exploratory science for mental health. These biological changes provide some explicit insight into the complex area of ‘brain-mind and behavior’. One major achievement of research in biological field is the finding to explain how biological factors cause changes in behavior. In India, we have a clear history of initiatives in research from a biological perspective, which goes back to 1958. In the last 61 years, this field has seen significant evolution, precision and effective utilization of contemporary technological advances. It is a matter of great pride to see that in spite of difficult times in terms of challenges of practice and services, administration, resource, funding and manpower the zest for research was very forthcoming. There was neither dedicated time nor any funding for conducting research. It came from the intellectual insight of our fore fathers in the field of mental health to gradually grow to the state of strategic education in research, training in research, international research collaborations and setting up of internationally accredited centers. During difficult economic conditions in the past, the hypothesis tested and conclusions derived have not been so important. It is more important how it was done, how it was made possible and how robust traditions were established. Almost an entire spectrum of biological research has been touched upon by Indian researchers. Some of these are electroconvulsive therapy, biological markers, neurocognition, neuroimaging, neuroendocrine, neurochemistry, electrophysiology and genetics. A lot has been published given the limited space in the Indian Journal of Psychiatry and other medical journals published in India. A large body of biological research conducted on Indian patients has also been published in International literature (which I prefer to call non-Indian journals). Newer research questions in biological psychiatry, keeping with trend of international standards are currently being investigated by the younger generation with great enthusiasm. What we have achieved so far is the foundation work in last 60 years. Our main challenge in development of biological psychiatry research in India remains resources in terms of manpower, funding and dedicated time for research psychiatrists. Developing basic sciences laboratories, discrete research questions, high quality methodology, and logistical support are some of the essentials. In the present time the culture of research has changed. It is specific and evidence-based. We have time-tested examples of International collaborative research. We need to get more resources, develop education, collaboration and effective leadership. In times to come, India will provide international leadership in basic and clinical biological psychiatry. There is hope. PMID:21836666

Stable Isotope Applications for Understanding Shark Ecology in the Northeast Pacific Ocean.

PubMed

Reum, Jonathan C P; Williams, Gregory D; Harvey, Chris J

Stable isotopes are used to address a wide range of ecological questions and can help researchers and managers better understand the movement and trophic ecology of sharks. Here, we review how shark studies from the Northeast Pacific Ocean (NEP) have employed stable isotopes to estimate trophic level and diet composition and infer movement and habitat-use patterns. To date, the number of NEP shark studies that have used stable isotopes is limited, suggesting that the approach is underutilized. To aid shark researchers in understanding the strengths and limitations of the approach, we provide a brief overview of carbon and nitrogen stable isotope trophic discrimination properties (e.g., change in δ 15 N between predator and prey), tissue sample preparation methods specific to elasmobranchs, and methodological considerations for the estimation of trophic level and diet composition. We suggest that stable isotopes are a potentially powerful tool for addressing basic questions about shark ecology and are perhaps most valuable when combined and analysed with other data types (e.g., stomach contents, tagging data, or other intrinsic biogeochemical markers). © 2017 Elsevier Ltd. All rights reserved.

Self-assessment of current knowledge in nuclear medicine (second edition)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Selby, J.B.; Frey, G.D.; Cooper, J.F.

1981-01-01

In this updated second edition, the order of contents of the textbook has been reorganized. It has been divided into main parts: Basic Science and Clinical Nuclear Medicine. Basic Science, Part I, encompasses basic physics, radiation protection, interaction of radiation with matter and radiation detection, imaging, nuclear pharmacy, and radiation biology. Part II, Clinical Nuclear Medicine, covers the central nervous system, bone, gastroenterology (liver/spleen), cardiovascular system, pulmonary system, genitourinary system, thyroid and endocrine systems, gallium studies, radioassay, hematology, and therapy. The total number of pages of the current edition is increased to 250 from the 213 of the first editionmore » but there are fewer questions because those in the basic science area have been carefully selected to 60 of the original 98 questions. Compared with the previous edition, there are two advantages in the current one: (1) the addition of explanatory answers; and (2) the inclusion of up-to-date scintiphotos replacing rectilinear scan illustrations.« less

Recovery concept in a Norwegian setting to be examined by the assertive community treatment model and mixed methods.

PubMed

Lofthus, Ann-Mari; Westerlund, Heidi; Bjørgen, Dagfinn; Lindstrøm, Jonas Christoffer; Lauveng, Arnhild; Rose, Diana; Ruud, Torleif; Heiervang, Kristin

2018-02-01

Recovery is a crucial concept in the mental health field. The research of recovery is split into the categories of personal, social and clinical recovery. The purpose of this study was to explore the fragmented concept of recovery in light of assertive community treatment (ACT) in Norway. The study has a mixed methods design with a pragmatic approach. The Questionnaire about the Process of Recovery and open-ended questions posed to 70 participants from 12 ACT teams in Norway, gathered by the "Users interview users" method, are combined with interviews or focus groups with eight of these participants. Surprisingly those under a community treatment order (CTO) report the highest degree of personal recovery. The qualitative material shows that the service users interpreted the concept of recovery differently than researchers and professionals. The ACT service users highlighted three important elements: flexible treatment, medication and access to a car. They emphasized the necessity for basic needs to be met in order to experience a meaningful recovery process, and these basic needs may be of even greater importance to those under CTOs. Their experiences should imply a greater emphasis on securing basic needs such as secure housing, sounder finances and access to the normal benefits offered by society. © 2016 Australian College of Mental Health Nurses Inc.

Clinical caring science as a scientific discipline.

PubMed

Rehnsfeldt, Arne; Arman, Maria; Lindström, Unni Å

2017-09-01

Clinical caring science will be described from a theory of science perspective. The aim of this theoretical article to give a comprehensive overview of clinical caring science as a human science-based discipline grounded in a theory of science argumentation. Clinical caring science seeks idiographic or specific variations of the ontology, concepts and theories, formulated by caring science. The rationale is the insight that the research questions do not change when they are addressed in different contexts. The academic subject contains a concept order with ethos concepts, core and basic concepts and practice concepts that unites systematic caring science with clinical caring science. In accordance with a hermeneutic tradition, the idea of the caring act is based on the degree to which the theory base is hermeneutically appropriated by the caregiver. The better the ethos, essential concepts and theories are understood, the better the caring act can be understood. In order to understand the concept order related to clinical caring science, an example is given from an ongoing project in a disaster context. The concept order is an appropriate way of making sense of the essence of clinical caring science. The idea of the concept order is that concepts on all levels need to be united with each other. A research project in clinical caring science can start anywhere on the concept order, either in ethos, core concepts, basic concepts, practice concepts or in concrete clinical phenomena, as long as no parts are locked out of the concept order as an entity. If, for example, research on patient participation as a phenomenon is not related to core and basic concepts, there is a risqué that the research becomes meaningless. © 2016 Nordic College of Caring Science.

Mixed methods research in music therapy research.

PubMed

Bradt, Joke; Burns, Debra S; Creswell, John W

2013-01-01

Music therapists have an ethical and professional responsibility to provide the highest quality care possible to their patients. Much of the time, high quality care is guided by evidence-based practice standards that integrate the most current, available research in making decisions. Accordingly, music therapists need research that integrates multiple ways of knowing and forms of evidence. Mixed methods research holds great promise for facilitating such integration. At this time, there have not been any methodological articles published on mixed methods research in music therapy. The purpose of this article is to introduce mixed methods research as an approach to address research questions relevant to music therapy practice. This article describes the core characteristics of mixed methods research, considers paradigmatic issues related to this research approach, articulates major challenges in conducting mixed methods research, illustrates four basic designs, and provides criteria for evaluating the quality of mixed methods articles using examples of mixed methods research from the music therapy literature. Mixed methods research offers unique opportunities for strengthening the evidence base in music therapy. Recommendations are provided to ensure rigorous implementation of this research approach.

Dissolution-modulating mechanism of pH modifiers in solid dispersion containing weakly acidic or basic drugs with poor water solubility.

PubMed

Tran, Phuong Ha-Lien; Tran, Thao Truong-Dinh; Lee, Kyoung-Ho; Kim, Dong-Jin; Lee, Beom-Jin

2010-05-01

Although the solid dispersion method has been known to increase the dissolution rate of poorly water-soluble drugs by dispersing them in hydrophilic carriers, one obstacle of the solid dispersion method is its limited solubilization capacity, especially for pH-dependent soluble drugs. pH-modified solid dispersion, in which pH modifiers are incorporated, may be a useful method for increasing the dissolution rate of weakly acidic or basic drugs. Sufficient research, including the most recent reports, was undertaken in this review. How could the inclusion of the pH the pH modifiers in the solid dispersion system change drug structural behaviors, molecular interactions, microenvironmental pH, and/or release rate of pH modifiers, relating with the enhanced dissolution of weakly acidic or weakly basic drugs with poor water solubility? These questions have been investigated to determine the dissolution-modulating mechanism of pH modifiers in solid dispersion containing weakly acidic or basic drugs. It is believed that step-by-step mechanistic approaches could provide the ultimate solution for solubilizing several poorly water-soluble drugs with pH-dependent solubility from a solid dispersion system, as well as provide ideas for developing future dosage systems.

Ethical and Clinical Considerations at the Intersection of Functional Neuroimaging and Disorders of Consciousness.

PubMed

Byram, Adrian C; Lee, Grace; Owen, Adrian M; Ribary, Urs; Stoessl, A Jon; Townson, Andrea; Illes, Judy

2016-10-01

Recent neuroimaging research on disorders of consciousness provides direct evidence of covert consciousness otherwise not detected clinically in a subset of severely brain-injured patients. These findings have motivated strategic development of binary communication paradigms, from which researchers interpret voluntary modulations in brain activity to glean information about patients' residual cognitive functions and emotions. The discovery of such responsiveness raises ethical and legal issues concerning the exercise of autonomy and capacity for decisionmaking on matters such as healthcare, involvement in research, and end of life. These advances have generated demands for access to the technology against a complex background of continued scientific advancement, questions about just allocation of healthcare resources, and unresolved legal issues. Interviews with professionals whose work is relevant to patients with disorders of consciousness reveal priorities concerning further basic research, legal and policy issues, and clinical considerations.

Research, science and technology parks: A global comparison of best practices

NASA Astrophysics Data System (ADS)

Ruiz Villacres, Hugo D.

The purpose of this study was to determine if significant differences exist in the evaluation of effectiveness and efficiency between North American, European, and Asian research parks (RPs). Park directors and staff responded to 25 questions from the Survey for Research, Science and Technology Parks. Effectiveness was measured by director's perception of the RP's contribution to economic growth and job creation. Efficiency was evaluated by the interactions between local universities and research parks, assessment of the ecosystem's basic characteristics, and the culture of innovation in the ecosystem. A stratified sampling procedure from a population of 793 parks was used; analysis of variance (ANOVA) and multivariate analysis of variance (MANOVA) were used to test for significance. 130 RPs from three continents participated in this study. No significant differences were found in the evaluation of RPs' directors on effectiveness and efficiency of RPs.

Space Rocks Tell Their Secrets: Space Science Applications of Physics and Chemistry for High School and College Classes: Update

NASA Technical Reports Server (NTRS)

Lindstrom, M. M.; Tobola, K. W.; Stocco, K.; Henry, M.; Allen, J. S.; McReynolds, Julie; Porter, T. Todd; Veile, Jeri

2004-01-01

As the scientific community studies Mars remotely for signs of life and uses Martian meteorites as its only available samples, teachers, students, and the general public continue to ask, How do we know these meteorites are from Mars? This question sets the stage for a six-lesson instructional package Space Rocks Tell Their Secrets. Expanding on the short answer It s the chemistry of the rock , students are introduced to the research that reveals the true identities of the rocks. Since few high school or beginning college students have the opportunity to participate in this level of research, a slide presentation introduces them to the labs, samples, and people involved with the research. As they work through the lessons and interpret authentic data, students realize that the research is an application of two basic science concepts taught in the classroom, the electromagnetic spectrum and isotopes.

Overview and research agenda arising from the 7th World Workshop on Oral Health and Disease in AIDS.

PubMed

Tappuni, A R; Shiboski, C

2016-04-01

The Research Agenda generated by the 7th World Workshop on Oral Health and Disease in AIDS (WW7) is delivered in this paper. Panels of international experts presided over nine workshops that constituted the conference held in November 2014 in Hyderabad, India. The main goal of the Workshop was to bring together clinician and scientists interested in the subject to debate with world-wide perspectives current issues related to the oral manifestations in HIV/AIDS. The workshops were structured around three themes; basic science, clinical/translational science and social science and were attended by 135 participants from 31 countries. The research questions debated at the workshops are presented in nine consensus papers published in this issue and are summarised in this paper along with an outline of the identified research needs in the field. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Remote sensing research in geographic education: An alternative view

NASA Technical Reports Server (NTRS)

Wilson, H.; Cary, T. K.; Goward, S. N.

1981-01-01

It is noted that within many geography departments remote sensing is viewed as a mere technique a student should learn in order to carry out true geographic research. This view inhibits both students and faculty from investigation of remotely sensed data as a new source of geographic knowledge that may alter our understanding of the Earth. The tendency is for geographers to accept these new data and analysis techniques from engineers and mathematicians without questioning the accompanying premises. This black-box approach hinders geographic applications of the new remotely sensed data and limits the geographer's contribution to further development of remote sensing observation systems. It is suggested that geographers contribute to the development of remote sensing through pursuit of basic research. This research can be encouraged, particularly among students, by demonstrating the links between geographic theory and remotely sensed observations, encouraging a healthy skepticism concerning the current understanding of these data.

A basic recursion concept inventory

NASA Astrophysics Data System (ADS)

Hamouda, Sally; Edwards, Stephen H.; Elmongui, Hicham G.; Ernst, Jeremy V.; Shaffer, Clifford A.

2017-04-01

Recursion is both an important and a difficult topic for introductory Computer Science students. Students often develop misconceptions about the topic that need to be diagnosed and corrected. In this paper, we report on our initial attempts to develop a concept inventory that measures student misconceptions on basic recursion topics. We present a collection of misconceptions and difficulties encountered by students when learning introductory recursion as presented in a typical CS2 course. Based on this collection, a draft concept inventory in the form of a series of questions was developed and evaluated, with the question rubric tagged to the list of misconceptions and difficulties.

Zero/zero rotorcraft certification issues. Volume 2: Plenary session presentations

NASA Technical Reports Server (NTRS)

Adams, Richard J.

1988-01-01

This report analyzes the Zero/Zero Rotorcraft Certification Issues from the perspectives of manufacturers, operators, researchers and the FAA. The basic premise behind this analysis is that zero/zero, or at least extremely low visibility, rotorcraft operations are feasible today from both a technological and an operational standpoint. The questions and issues that need to be resolved are: What certification requirements do we need to ensure safety. Can we develop procedures which capitalize on the performance and maneuvering capabilities unique to rotorcraft. Will extremely low visibility operations be economically feasible. This is Volume 2 of three. It presents the operator perspectives (system needs), applicable technology and zero/zero concepts developed in the first 12 months of research of this project.

Network architecture test-beds as platforms for ubiquitous computing.

PubMed

Roscoe, Timothy

2008-10-28

Distributed systems research, and in particular ubiquitous computing, has traditionally assumed the Internet as a basic underlying communications substrate. Recently, however, the networking research community has come to question the fundamental design or 'architecture' of the Internet. This has been led by two observations: first, that the Internet as it stands is now almost impossible to evolve to support new functionality; and second, that modern applications of all kinds now use the Internet rather differently, and frequently implement their own 'overlay' networks above it to work around its perceived deficiencies. In this paper, I discuss recent academic projects to allow disruptive change to the Internet architecture, and also outline a radically different view of networking for ubiquitous computing that such proposals might facilitate.

A Computerized Content Analysis of the Perceived Criterion Categories for the "Speech to Inform" of Inexperienced and Experienced Basic Course Students.

ERIC Educational Resources Information Center

Jones, Tom; Di Salvo, Vince

A computerized content analysis of the "theory input" for a basic speech course was conducted. The questions to be answered were (1) What does the inexperienced basic speech student hold as a conceptual perspective of the "speech to inform" prior to his being subjected to a college speech class? and (2) How does that inexperienced student's…

Participatory assessment of the environment from children's viewpoints: development of a method and its trial.

PubMed

Moriyama, M; Suwa, T; Kabuto, M; Fukushima, T

2001-02-01

To understand the actual viewpoints of children about daily life and the environment, the authors, adopting a participatory strategy, visited 21 classes of Japanese school children, improved in a stepwise process their ways of question-asking, and developed "WIFY"(what is important for you); a set of interactive questions composed of a basic question and three accompanying instructions. In applying WIFY, 59 fourth graders, 22 in Nagasaki, Japan and 37 in Beijing, China, reported their viewpoints in each of classroom settings. In both settings, when children were allowed to communicate with each other by the use of WIFY answering sheet, spontaneous exchanges arose and continued. WIFY itself is supposed to bring out and enhance mutual collaboration and spontaneous networking. In this instance, WIFY functioned as a communication tool. When answering sheets were collected and obtained responses were analyzed as cases, a rather materialistic view was suggested among Japanese children and a more disciplined view, which put much value on school and home, was suggested among Chinese children. Further studies are needed to confirm the changing environmental views of children from the collaborative research framework.

The Ethical Challenges of Socially Responsible Science

PubMed Central

Resnik, David B.; Elliott, Kevin C.

2015-01-01

Social responsibility is an essential part of the responsible conduct of research that presents difficult ethical questions for scientists. Recognizing one’s social responsibilities as a scientist is an important first step toward exercising social responsibility, but it is only the beginning, since scientists may confront difficult value questions when deciding how to act responsibly. Ethical dilemmas related to socially responsible science fall into at least three basic categories: 1) dilemmas related to problem selection, 2) dilemmas related to publication and data sharing, and 3) dilemmas related to engaging society. In responding to these dilemmas, scientists must decide how to balance their social responsibilities against other professional commitments and how to avoid compromising their objectivity. In this article, we will examine the philosophical and ethical basis of social responsibility in science, discuss some of the ethical dilemmas related to exercising social responsibility, and make five recommendations to help scientists deal with these issues. PMID:26193168

Gravitropic responses of plants in the absence of a complicating G-force (6-IML-1)

NASA Technical Reports Server (NTRS)

Brown, Allan H.

1992-01-01

On the Earth it is patently impossible to measure any tropistic, physiologic, or morphogenic reactions to environmental stimuli without taking into account our planet's gravitational influence on the time course of the test subject's response. It follows that all published reports of quantitative measurements of such responses must have been contaminated by an additional gravity dependent component which probably was not trivial. Our research effort has as its principal scientific objective, the acquisition of experimental data from tests in a microgravity environment that will address a number of basic questions about plants' gravitropic responses to the perception of transversely applied g forces in the hypogravity range, from essentially zero to unit g. Comparable tests on Earth but in the same flight hardware, referred to as the Gravitational Plant Physiology Facility (GPPF), will provide 1 g data for various useful comparisons. Four specific scientific questions are addressed.

Styles and Style-Stretching: How are They Related to Successful Learning?

PubMed

Griffiths, Carol; İnceçay, Görsev

2016-06-01

Although the learning style construct has aroused much interest over the years, questions remain regarding basic issues such as definition, the validity and/or reliability of various measurement instruments, and the relationship between learning style and successful learning. Furthermore, although maintaining stylistic flexibility is recommended by many authors, few studies have attempted to relate the style-stretching concept to successful learning. This study therefore attempted to address these questions. According to results, conducted among 106 Turkish university students, using an original instrument constructed using elements from established questionnaires, a small group of styles was significantly correlated with exam results, accounting for about a quarter of the variance (considered a large effect size in social science). In addition, higher-scoring students reported a more eclectic range of styles, suggesting more willingness to style-stretch, while lower-scoring students reported a more limited range. Pedagogical implications as well as areas for ongoing research are suggested.

The Ethical Challenges of Socially Responsible Science.

PubMed

Resnik, David B; Elliott, Kevin C

2016-01-01

Social responsibility is an essential part of the responsible conduct of research that presents difficult ethical questions for scientists. Recognizing one's social responsibilities as a scientist is an important first step toward exercising social responsibility, but it is only the beginning, since scientists may confront difficult value questions when deciding how to act responsibly. Ethical dilemmas related to socially responsible science fall into at least three basic categories: 1) dilemmas related to problem selection, 2) dilemmas related to publication and data sharing, and 3) dilemmas related to engaging society. In responding to these dilemmas, scientists must decide how to balance their social responsibilities against other professional commitments and how to avoid compromising their objectivity. In this article, we will examine the philosophical and ethical basis of social responsibility in science, discuss some of the ethical dilemmas related to exercising social responsibility, and make five recommendations to help scientists deal with these issues.

Improving School Bus Driver Performance.

ERIC Educational Resources Information Center

Farmer, Ernest

This reference source is intended to assist the school bus driver training instructor in course preparation. Instructional units for program planning each contain pertinent course questions, a summary, and evaluation questions. Unit 1, "Introduction to the School Bus Driver Training Program," focuses on basic course objectives and…

Student concepts of Natural Selection from a resource-based perspective

NASA Astrophysics Data System (ADS)

Benjamin, Scott Shawn

The past two decades have produced a substantial amount of research about the teaching and learning of evolution; however, recent research often lacks a theoretical foundation. Application of a new theoretical framework could help fill the void and improve research about student concepts of evolution. This study seeks to show that a resource-based framework (Hammer et al., 2005) can improve research into student concepts of natural selection. Concepts of natural selection from urban community college students were assessed via qualitative (interviews, written open-response questions, and write/think aloud procedures) and quantitative methods (coded open response analysis, Concept Inventory for Natural Selection (CINS)(Anderson, Fisher, & Norman, 2002). Results showed that students demonstrate four important aspects of resource-based framework: the multi-faceted construction of concepts, context sensitivity/ concept flexibility, at-the-moment activation of resources, and perceptual frames. In open response assessment, evolutionary-gain responses produced significantly different responses than evolutionary-loss questions with: 1) significantly more correct answers for the gain than loss question (Wilcoxon signed rank test, z = -3.68, p=0.0002); 2) more Lamarckian responses to loss than the gain question (Fisher exact, p=0.0039); and significantly different distributions in expanded need vs basic need answers (Fishers exact, p = 0.02). Results from CINS scores showed significant differences in post activity scores between students that held different naive concepts associated with origin of variation, origin of species, differential reproduction, and limited survival suggesting that some naive ideas facilitate learning. Outcomes also suggest that an everyday or self-experience typological perceptual frame is an underlying source of many incorrect ideas about evolution. Interview and write/think aloud assessments propose four process resources applied by students as they explain evolutionary change: list what I know, why story, compare past to present, mapping self-experience. The study concludes that a resource-based framework is a valuable tool to advance the study student concepts of natural selection.

Taking the cooking out of food: nutrition & the national curriculum.

PubMed

Stitt, S; Jepson, M; Paulson-Box, E

1995-01-01

This is a discussion paper which generates some important research questions for educationalists. The teaching of food skills are at danger of being lost from the school cirriculum by changes imposed by the National Curriculum. This sinister (i.e., unexplained/undefined) development generates potential problems for the teaching of cookery and for the food and eating traditions of British society. The central concern for nutrition educationalists is that cooking is becoming more and more de-domesticated and consequently will become more systemised, more mass produced; in which case, young people need not be educated in basic cooking skills.

Student opinion in England about science and technology

NASA Astrophysics Data System (ADS)

Jenkins, Edgar W.

2006-05-01

An earlier paper in this Journal (Jenkins & Nelson, 2005) drew upon the findings of the Relevance of Science Education Project (ROSE) to report the attitudes of students in England towards their secondary school science education. The present paper draws upon the same project to explore what the same students, almost all in their penultimate year of compulsory schooling, think about science and technology. It suggests that several basic research questions need to be addressed and answered if the present widespread decline in the industrialised world in the popularity of the physical sciences as subjects of advanced study is to be halted.

PACE team response shows a disregard for the principles of science.

PubMed

Edwards, Jonathan

2017-08-01

The PACE trial of cognitive behavioural therapy and graded exercise therapy for chronic fatigue syndrome/myalgic encephalomyelitis has raised serious questions about research methodology. An editorial article by Geraghty gives a fair account of the problems involved, if anything understating the case. The response by White et al. fails to address the key design flaw, of an unblinded study with subjective outcome measures, apparently demonstrating a lack of understanding of basic trial design requirements. The failure of the academic community to recognise the weakness of trials of this type suggests that a major overhaul of quality control is needed.

Alternatives for jet engine control

NASA Technical Reports Server (NTRS)

Sain, M. K.

1981-01-01

Research centered on basic topics in the modeling and feedback control of nonlinear dynamical systems is reported. Of special interest were the following topics: (1) the role of series descriptions, especially insofar as they relate to questions of scheduling, in the control of gas turbine engines; (2) the use of algebraic tensor theory as a technique for parameterizing such descriptions; (3) the relationship between tensor methodology and other parts of the nonlinear literature; (4) the improvement of interactive methods for parameter selection within a tensor viewpoint; and (5) study of feedback gain representation as a counterpart to these modeling and parameterization ideas.

Electrochemical characterization of nanodimensional metal oxide materials

NASA Astrophysics Data System (ADS)

Tang, Paul Enle

Energy storage devices have become a bottleneck in performance improvements for portable electronics. This research seeks to answer basic science questions that may lead to the necessary improvements. First, this work demonstrates that insertion of multivalent ions into vanadium oxide greatly exceeds the storage capacity of materials presently used. Second, this work demonstrates that potassium ferrate exhibits a uniquely large pseudocapacitive effect. This effect can be used to great advantage when high power density and high energy density are required. Lastly, this work proposes a model of pseudocapacitance that has a greater descriptive power than that of previous models.

32 CFR 272.3 - Definition of basic research.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 2 2014-07-01 2014-07-01 false Definition of basic research. 272.3 Section 272...) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.3 Definition of basic research. Basic research is systematic study directed toward greater knowledge or understanding of...

32 CFR 272.3 - Definition of basic research.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 2 2012-07-01 2012-07-01 false Definition of basic research. 272.3 Section 272...) MISCELLANEOUS ADMINISTRATION AND SUPPORT OF BASIC RESEARCH BY THE DEPARTMENT OF DEFENSE § 272.3 Definition of basic research. Basic research is systematic study directed toward greater knowledge or understanding of...

Toxic red tides and harmful algal blooms: A practical challenge in coastal oceanography

NASA Astrophysics Data System (ADS)

Anderson, Donald M.

1995-07-01

The debate over the relative value of practical or applied versus fundamental research has heated up considerably in recent years, and oceanography has not been spared this re-evaluation of science funding policy. Some federal agencies with marine interests have always focused their resources on practical problems, but those with a traditional commitment to basic research such as the National Science Foundation have increasingly had to fight to maintain their freedom to fund quality science without regard to practical or commercial applications. Within this context, it is instructive to highlight the extent to which certain scientific programs can satisfy both sides of this policy dilemma—i.e. address important societal issues through advances in fundamental or basic research. One clear oceanographic example of such a program involves the phenomena called "red tides" or "harmful algal blooms". This paper describes the nature and extent of the problems caused by these outbreaks, emphasizing the alarming expansion in their incidence and their impacts in recent years, both in the U.S. and worldwide. The objective is to highlight fundamental physical, biological, and chemical oceanographic question that must be addressed if we are to achieve the practical goal of scientifically based management of fisheries resources, public health, and ecosystem health in regions threatened by toxic and harmful algae.

A Transparent Window into Biology: A Primer on Caenorhabditis elegans.

PubMed

Corsi, Ann K; Wightman, Bruce; Chalfie, Martin

2015-06-01

A little over 50 years ago, Sydney Brenner had the foresight to develop the nematode (round worm) Caenorhabditis elegans as a genetic model for understanding questions of developmental biology and neurobiology. Over time, research on C. elegans has expanded to explore a wealth of diverse areas in modern biology including studies of the basic functions and interactions of eukaryotic cells, host-parasite interactions, and evolution. C. elegans has also become an important organism in which to study processes that go awry in human diseases. This primer introduces the organism and the many features that make it an outstanding experimental system, including its small size, rapid life cycle, transparency, and well-annotated genome. We survey the basic anatomical features, common technical approaches, and important discoveries in C. elegans research. Key to studying C. elegans has been the ability to address biological problems genetically, using both forward and reverse genetics, both at the level of the entire organism and at the level of the single, identified cell. These possibilities make C. elegans useful not only in research laboratories, but also in the classroom where it can be used to excite students who actually can see what is happening inside live cells and tissues. Copyright © 2015 Corsi, Wightman, and Chalfie.

[SONG's theory on mast cells and meridian-acupoint and its research prospect].

PubMed

Li, Yongming

2016-10-12

The historical origin of researches regarding acupuncture and mast cells (MCs) is reviewed, and the hypothesis that dermal MCs might be correlated with the acupuncture phenomena proposed by SONG Jimei in 1977 is introduced. This hypothesis, for the first time, suggests MCs could be the cellular basis of meridian sensation and arrival of qi ( deqi ) of acupoints. With independent tests of several research institutes, currently sufficient evidences prove the scientific values of SONG 's theory as well as its potential values for the basic research and clinical practice of acupuncture. It is reported recently that MCs might receive signals from central nerve system and acupoint stimulation, showing cross-talk effects, therefore, MCs can be sensitized at acupoints. In this paper, with a review of 40-year research evidence, 15 biological characteristics regarding mast cells and acupuncture phenomena are identified, in the meanwhile, 10 key questions and research direction, including the distribution of MCs in skin and its general relationship with meridian-acupoint, etc. are proposed.

Establishing a Twin Register: An Invaluable Resource for (Behavior) Genetic, Epidemiological, Biomarker, and 'Omics' Studies.

PubMed

Odintsova, Veronika V; Willemsen, Gonneke; Dolan, Conor V; Hottenga, Jouke-Jan; Martin, Nicholas G; Slagboom, P Eline; Ordoñana, Juan R; Boomsma, Dorret I

2018-06-01

Twin registers are wonderful research resources for research applications in medical and behavioral genetics, epidemiology, psychology, molecular genetics, and other areas of research. New registers continue to be launched all over the world as researchers from different disciplines recognize the potential to boost and widen their research agenda. In this article, we discuss multiple aspects that need to be taken into account when initiating a register, from its preliminary sketch to its actual development. This encompasses aspects related to the strategic planning and key elements of research designs, promotion and management of a twin register, including recruitment and retaining of twins and family members of twins, phenotyping, database organization, and collaborations between registers. We also present information on questions unique to twin registers and twin-biobanks, such as the assessment of zygosity by SNP arrays, the design of (biomarker) studies involving related participants, and the analyses of clustered data. Altogether, we provide a number of basic guidelines and recommendations for reflection when planning a twin register.

Regulatory physiology discipline science plan

NASA Technical Reports Server (NTRS)

1991-01-01

The focus of the Regulatory Physiology discipline of the Space Physiology and Countermeasures Program is twofold. First, to determine and study how microgravity and associated factors of space flight affect the regulatory mechanisms by which humans adapt and achieve homeostasis and thereby regulate their ability to respond to internal and external signals; and, second, to study selected physiological systems that have been demonstrated to be influenced by gravity. The Regulatory Physiology discipline, as defined here, is composed of seven subdisciplines: (1) Circadian Rhythms, (2) Endocrinology, (3) Fluid and Electrolyte Regulation, (4) Hematology, (5) Immunology, (6) Metabolism and Nutrition, and (7) Temperature Regulation. The purpose of this Discipline Science Plan is to provide a conceptual strategy for NASA's Life Sciences Division research and development activities in the area of regulatory physiology. It covers the research areas critical to NASA's programmatic requirements for the Extended-Duration Orbiter, Space Station Freedom, and exploration mission science activities. These science activities include ground-based and flight; basic, applied, and operational; and animal and human research and development. This document summarizes the current status of the program, outlines available knowledge, establishes goals and objectives, identifies science priorities, and defines critical questions in regulatory physiology. It contains a general plan that will be used by both NASA Headquarters Program Offices and the field centers to review and plan basic, applied, and operational intramural and extramural research and development activities in this area.

Empirical studies of clinical supervision in psychiatric nursing: A systematic literature review and methodological critique.

PubMed

Buus, Niels; Gonge, Henrik

2009-08-01

The objective of this paper was to systematically review and critically evaluate all English language research papers reporting empirical studies of clinical supervision in psychiatric nursing. The first part of the search strategy was a combination of brief and building block strategies in the PubMed, CINAHL, and PsycINFO databases. The second part was a citation pearl growing strategy with reviews of 179 reference lists. In total, the search strategy demonstrated a low level of precision and a high level of recall. Thirty four articles met the criteria of the review and were systematically evaluated using three checklists. The findings were summarized by using a new checklist with nine overall questions regarding the studies' design, methods, findings, and limitations. The studies were categorized as: (i) effect studies; (ii) survey studies; (iii) interview studies; and (iv) case studies. In general, the studies were relatively small scale; they used relatively new and basic methods for data collection and analysis, and rarely included sufficient strategies for identifying confounding factors or how the researchers' preconceptions influenced the analyses. Empirical research of clinical supervision in psychiatric nursing was characterized by a basic lack of agreement about which models and instruments to use. Challenges and recommendations for future research are discussed. Clinical supervision in psychiatric nursing was commonly perceived as a good thing, but there was limited empirical evidence supporting this claim.

Portuguese Basic Courses.

ERIC Educational Resources Information Center

Defense Language Inst., Washington, DC.

This basic course in Brazilian Portuguese consists of 75 lessons in six volumes. Volume I is in two parts, with the dialogs, questions and exercises presented in Portuguese in the first part, and the intonation patterns and English translations presented in the second. The general format follows the Defense Language Institute format, employing…

Using Every Pupil Response in Mathematics Instruction.

ERIC Educational Resources Information Center

Lauritzen, Carol

1985-01-01

Discusses the "Every Pupil Response" (EPR) strategy and its use in teaching basic facts, problem-solving, place value, and fractions. Basically, the technique involves children responding simultaneously to a question by holding up a card, using parts of their bodies, or stick figures. Advantages of EPR are noted. (JN)

HEALTH AND NUTRITION LESSON PLANS AND STUDENT WORKSHEETS, ADULT BASIC EDUCATION.

ERIC Educational Resources Information Center

New York State Education Dept., Albany.

THIS MANUAL PROVIDES ADULT BASIC EDUCATION TEACHERS WITH LESSON PLANS IN HEALTH AND NUTRITION. EACH LESSON CONTAINS BACKGROUND MATERIAL OFFERING SPECIFIC INFORMATION ON THE SUBJECT OF EACH LESSON, AIMS, LESSON DEVELOPMENT, AND TWO STUDENT WORKSHEETS. DISCUSSION QUESTIONS ARE SUGGESTED TO ENCOURAGE THE GREATEST POSSIBLE STUDENT INVOLVEMENT. THE TEN…

Econosense: A Common Sense Approach to the Study of Economics.

ERIC Educational Resources Information Center

McPheron, Linda

This student activity book and teacher's guide address specific economic terms and concepts correlated to specific student learning objectives. The concepts presented are those essential to any student developing a basic understanding of economics. Each lesson follows a specific format with a basic core of information, comprehension questions,…

Manpower information and the community mental health system.

PubMed

Kamis-Gould, E; Staines, G L

1986-10-01

The lack of knowledge about basic manpower issues in the community mental health system led the authors to devise five questions that address manpower issues of general interest to community mental health system managers. The questions concern the ratio of staff to population, the types of professionals on staff and their demographic characteristics, the amount of time staff spend on various activities, the cost of the work force, and the outcomes of services. The authors discuss how these questions have been considered in the literature, and they illustrate with analyses of data from a survey of staff of New Jersey's mental health agencies how the issues of number, type, and cost of staff can be explored. The authors believe that basic manpower information can contribute directly to the decisions of managers of mental health service systems.

Soft Skills for Hard Impact

NASA Astrophysics Data System (ADS)

Grigorov, Ivo; Davidson, Joy; Knoth, Petr; Kuchma, Iryna; Schmidt, Birgit; Rettberg, Najla; Rogrigues, Eloy

2015-04-01

Marine and Earth Science graduates will be under increasing pressure in future to delve into research questions of relevance to societal challenges. Even fundamental research focused on basic processes of the environment and universe will in the coming decade need to justify their societal impact. As the Research Excellence Frameworks (REF) for research evaluation shift more and more away from the classical Impact Factor and number of peer-reviewed publications to "societal impact", the question remains whether the current graduates, and future researchers, are sufficiently prepared to deal with this reality. The essential compliment of skills beyond research excellence, rigor and method are traditionally described as "soft skills". This includes how to formulate an argument, how to construct a scientific publication, how to communicate such publications to non-experts, place them in context of societal challenges and relevant policies, how to write a competitive proposal and "market" one's research idea to build a research group around an interesting research topic. Such "soft skills" can produce very measurable and concrete impact for career development, but are rarely provided systematically and coherently by graduate schools in general. The presentation will focus on Open Science as a set of "soft skills", and demonstrate why graduate schools should train Open Science competencies alongside research excellence by default. Open Science is about removing all barriers to research process and outputs, both published and unpublished, and directly supports transparency and reproducibility of the research process. Open Science as a set of news competencies can also foster unexpected collaborations, engage citizen scientists into co-creation of solutions to societal challenges, as well as use concepts of Open Science to transfer new knowledge to the knowledge-based private sector, and help them with formulating more competitive research proposals in future.

On Productive Knowledge and Levels of Questions.

ERIC Educational Resources Information Center

Andre, Thomas

A model is proposed for memory that stresses a distinction between episodic memory for encoded personal experience and semantic memory for abstractors and generalizations. Basically, the model holds that questions influence the nature of memory representations formed during instruction, and that memory representation controls the way in which…

Delayed Reinforcement of Operant Behavior

ERIC Educational Resources Information Center

Lattal, Kennon A.

2010-01-01

The experimental analysis of delay of reinforcement is considered from the perspective of three questions that seem basic not only to understanding delay of reinforcement but also, by implication, the contributions of temporal relations between events to operant behavior. The first question is whether effects of the temporal relation between…

Attention Deficit Disorder. NICHCY Briefing Paper.

ERIC Educational Resources Information Center

Fowler, Mary

This briefing paper uses a question-and-answer format to provide basic information about children with attention deficit disorder (ADD). Questions address the following concerns: nature and incidence of ADD; causes of ADD; signs of ADD (impulsivity, hyperactivity, disorganization, social skill deficits); the diagnostic ADD assessment; how to get…

Psychology, the Population Explosion, and the Question of Freedom and Dignity.

ERIC Educational Resources Information Center

Platzek, Donna Brown

This paper examines the question of why women want children from several disciplinary viewpoints including psychoanalysis; role learning; and economic, political, and religious aspects. Basically, however, childbearing motivations can be divided into four categories: altruistic, fatalistic, narcissistic, and instrumental. Children can fulfill a…

Basic Questions for Introductory Sociology.

ERIC Educational Resources Information Center

Parmley, Ingram C.

1980-01-01

Looks at five questions that serve as the core of an introductory sociology course, presenting the essence of sociology without inundating the student with information: What is sociology? How do societies develop rules for living? What if the rules don't work? How are new rules developed? So what? (AYC)

Growth of a Species, an Association, a Science: 80 Years of Growth and Development Research

PubMed Central

Sherwood, Richard J.; Duren, Dana L.

2014-01-01

Physical anthropological research was codified in the United States with the creation of the American Association of Physical Anthropology (AAPA) in 1929. That same year, a study began in yellow springs, Ohio, with a goal of identifying “what makes people different.” The approach used to answer that question was to study the growth and development of Homo sapiens. The resulting study, the Fels Longitudinal Study, is currently the longest continuous study of human growth and development in the world. Although the AAPA and the Fels Longitudinal Study have existed as separate entities for more than 80 years now, it is not surprising, given the relationship between anatomical and developmental research, there has been considerable overlap between the two. As the field of physical anthropology has blossomed to include subdisciplines such as forensics, genetics, primatology, as well as sophisticated statistical methodologies, the importance of growth and development research has escalated. Although current Fels Longitudinal Study research is largely directed at biomedical questions, virtually all findings are relevant to physical anthropology, providing insights into basic biological processes and life history parameters. Some key milestones from the early years of the AAPA and the Fels Longitudinal Study are highlighted here that address growth and development research in physical anthropology. These are still held as fundamental concepts that underscore the importance of this line of inquiry, not only across the subdisciplines of physical anthropology, but also among anthropological, biological, and biomedical inquiries. PMID:23283658

Growth of a species, an association, a science: 80 years of growth and development research.

PubMed

Sherwood, Richard J; Duren, Dana L

2013-01-01

Physical anthropological research was codified in the United States with the creation of the American Association of Physical Anthropology (AAPA) in 1929. That same year, a study began in yellow springs, Ohio, with a goal of identifying "what makes people different." The approach used to answer that question was to study the growth and development of Homo sapiens. The resulting study, the Fels Longitudinal Study, is currently the longest continuous study of human growth and development in the world. Although the AAPA and the Fels Longitudinal Study have existed as separate entities for more than 80 years now, it is not surprising, given the relationship between anatomical and developmental research, there has been considerable overlap between the two. As the field of physical anthropology has blossomed to include subdisciplines such as forensics, genetics, primatology, as well as sophisticated statistical methodologies, the importance of growth and development research has escalated. Although current Fels Longitudinal Study research is largely directed at biomedical questions, virtually all findings are relevant to physical anthropology, providing insights into basic biological processes and life history parameters. Some key milestones from the early years of the AAPA and the Fels Longitudinal Study are highlighted here that address growth and development research in physical anthropology. These are still held as fundamental concepts that underscore the importance of this line of inquiry, not only across the subdisciplines of physical anthropology, but also among anthropological, biological, and biomedical inquiries. Copyright © 2012 Wiley Periodicals, Inc.

Increase in counselling communication skills after basic and advanced microskills training.

PubMed

Kuntze, Jeroen; van der Molen, Henk T; Born, Marise P

2009-03-01

Mastering counselling communication skills is one of the requirements that lead to the diploma of a registered European psychologist. The microcounseling method proves to be effective in training these skills. Research into the effectiveness of the microcounseling method often reports overall effect sizes only. The aim of this study was to investigate the adequate use of separate counselling communication skills (seven basic skills: minimal encouragements; asking questions; paraphrasing; reflection of feeling; concreteness; summarizing; and situation clarification and five advanced skills: advanced accurate empathy; confrontation; positive relabelling; examples of one's own; and directness) after respectively a basic and an advanced training in these skills. Participants were 583 first year or second year bachelor students in psychology who took the counselling communication skills progress test (CSPT). The participants are divided in a group of freshmen, who had not received any training in counselling communication skills; first year students, who had received a training in basic skills; second year students who had followed a training in advanced skills and a control group. A between-subject design, a within-subject design and a pre-test-post-test-control group design were used to examine the scores on these skills. Seven basic skills and four advanced skills had large effect sizes. One advanced skill had a moderate effect size. The microcounseling method is very effective on the level of separate microskills. However, students perform better on the basic skills than on the advanced skills. More training seems to be needed in the latter to achieve the same level of mastery.

Your Scores in Basic Skills: Iowa Tests of Basic Skills. AISD Junior High Schools, School Year 1981-82. AISD Senior High Schools, School Year 1981-82.

ERIC Educational Resources Information Center

Austin Independent School District, TX.

Designed for junior high and high school students and their parents, this brochure explains the structure, function, and method for interpretation of the Iowa Tests of Basic Skills and the Sequential Tests of Educational Progress. A question and answer format is used to provide information on scope and purposes of the tests, meaning and accuracy…

Your Child's Scores in Basic Skills: Iowa Tests of Basic Skills. AISD Kindergarten, School Year 1981-82. AISD Elementary Schools, School Year 1981-82.

ERIC Educational Resources Information Center

Austin Independent School District, TX.

Designed for parents of kindergarten and elementary school children in Austin, Texas, this brochure explains the structure and function of the Iowa Tests of Basic Skills. A question and answer format is used to provide information on the scope and purposes of the tests, grade level differences in testing, meaning and accuracy of the scores, and…

Physiological effects of oral glucosamine on joint health: current status and consensus on future research priorities

PubMed Central

2013-01-01

The aim of this paper was to provide an overview of the current knowledge and understanding of the potential beneficial physiological effects of glucosamine (GlcN) on joint health. The objective was to reach a consensus on four critical questions and to provide recommendations for future research priorities. To this end, nine scientists from Europe and the United States were selected according to their expertise in this particular field and were invited to participate in the Hohenheim conference held in August 2011. Each expert was asked to address a question that had previously been posed by the chairman of the conference. Based on a systematic review of the literature and the collection of recent data, the experts documented the effects of GlcN on cartilage ageing, metabolic/kinetic and maintenance of joint health as well as reduction of risk of OA development. After extensive debate and discussion the expert panel addressed each question and a general consensus statement was developed, agreeing on the current state-of-the-art and future areas for basic and clinical studies. This paper summarizes the available evidence for beneficial effects of GlcN on joint health and proposes new insight into the design of future clinical trials aimed at identifying beneficial physiological effect of GlcN on joint tissues. PMID:23531101

Spontaneous ultraweak photon emission from biological systems and the endogenous light field.

PubMed

Schwabl, Herbert; Klima, Herbert

2005-04-01

Still one of the most astonishing biological electromagnetic phenomena is the ultraweak photon emission (UPE) from living systems. Organisms and tissues spontaneously emit measurable intensities of light, i.e. photons in the visible part of the electromagnetic spectrum (380-780 nm), in the range from 1 to 1,000 photons x s-1 x cm-2, depending on their condition and vitality. It is important not to confuse UPE from living systems with other biogenic light emitting processes such as bioluminescence or chemiluminescence. This article examines with basic considerations from physics on the quantum nature of photons the empirical phenomenon of UPE. This leads to the description of the non-thermal origin of this radiation. This is in good correspondence with the modern understanding of life phenomena as dissipative processes far from thermodynamic equilibrium. UPE also supports the understanding of life sustaining processes as basically driven by electromagnetic fields. The basic features of UPE, like intensity and spectral distribution, are known in principle for many experimental situations. The UPE of human leukocytes contributes to an endogenous light field of about 1011 photons x s-1 which can be influenced by certain factors. Further research is needed to reveal the statistical properties of UPE and in consequence to answer questions about the underlying mechanics of the biological system. In principle, statistical properties of UPE allow to reconstruct phase-space dynamics of the light emitting structures. Many open questions remain until a proper understanding of the electromagnetic interaction of the human organism can be achieved: which structures act as receptors and emitters for electromagnetic radiation? How is electromagnetic information received and processed within cells?

Querying Provenance Information: Basic Notions and an Example from Paleoclimate Reconstruction

NASA Astrophysics Data System (ADS)

Stodden, V.; Ludaescher, B.; Bocinsky, K.; Kintigh, K.; Kohler, T.; McPhillips, T.; Rush, J.

2016-12-01

Computational models are used to reconstruct and explain past environments and to predict likely future environments. For example, Bocinsky and Kohler have performed a 2,000-year reconstruction of the rain-fed maize agricultural niche in the US Southwest. The resulting academic publications not only contain traditional method descriptions, figures, etc. but also links to code and data for basic transparency and reproducibility. Examples include ResearchCompendia.org and the new project "Merging Science and Cyberinfrastructure Pathways: The Whole Tale." Provenance information provides a further critical element to understand a published study and to possibly extend or challenge the findings of the original authors. We present different notions and uses of provenance information using a computational archaeology example, e.g., the common use of "provenance for others" (for transparency and reproducibility), but also the more elusive but equally important use of "provenance for self". To this end, we distinguish prospective provenance (a.k.a. workflow) from retrospective provenance (a.k.a. data lineage) and show how combinations of both forms of provenance can be used to answer different kinds of important questions about a workflow and its execution. Since many workflows are developed using scripting or special purpose languages such as Python and R, we employ an approach and toolkit called YesWorkflow that brings provenance modeling, capture, and querying into the realm of scripting. YesWorkflow employs the basic W3C PROV standard, as well as the ProvONE extension for sharing and exchanging retrospective and prospective provenance information, respectively. Finally, we argue that the utility of provenance information should be maximized by developing different kinds provenance questions and queries during the early phases of computational workflow design and implementation.

Research priorities in the field of HIV and AIDS in Iran

PubMed Central

Haghdoost, AliAkbar; Sadeghi, Masoomeh; Nasirian, Maryam; Mirzazadeh, Ali; Navadeh, Soodabeh

2012-01-01

Background: HIV is a multidimensional problem. Therefore, prioritization of research topics in this field is a serious challenge. We decided to prioritize the major areas of research on HIV/AIDS in Iran. Materials ans Methods: In a brain-storming session with the main national and provincial stakeholders and experts from different relevant fields, the direct and indirect dimensions of HIV/AIDS and its related research issues were explored. Afterward, using the Delphi method, we sent questionnaires to 20 experts (13 respondents) from different sectors. In this electronic based questioner, we requested experts to evaluate main topics and their subtopics. The ranges of scores were between 0 and 100. Results: The score of priorities of main themes were preventive activities (43.2), large scale planning (25.4), the estimation of the HIV/AIDS burden (20.9), and basic scientific research (10.5). The most important priority in each main theme was education particularly in high risk groups (52.5), developing the national strategy to address the epidemic (31.8), estimation of the incidence and prevalence among high-risk groups (59.5) and developing new preventive methods (66.7), respectively. Conclusions: The most important priorities of researches on HIV/AIDS were preventive activities and developing national strategy. As high risk groups are the most involved people in the epidemic, and they are also the most hard-to-reach sub-populations, a national well designated comprehensive strategy is essential. However, we believe with a very specific and directed scheme, special attention to research in basic sciences is necessary, at least in limited number of institutes. PMID:23626616

The linguistic and interactional factors impacting recognition and dispatch in emergency calls for out-of-hospital cardiac arrest: a mixed-method linguistic analysis study protocol

PubMed Central

Riou, Marine; Ball, Stephen; Williams, Teresa A; Whiteside, Austin; O’Halloran, Kay L; Bray, Janet; Perkins, Gavin D; Cameron, Peter; Fatovich, Daniel M; Inoue, Madoka; Bailey, Paul; Brink, Deon; Smith, Karen; Della, Phillip; Finn, Judith

2017-01-01

Introduction Emergency telephone calls placed by bystanders are crucial to the recognition of out-of-hospital cardiac arrest (OHCA), fast ambulance dispatch and initiation of early basic life support. Clear and efficient communication between caller and call-taker is essential to this time-critical emergency, yet few studies have investigated the impact that linguistic factors may have on the nature of the interaction and the resulting trajectory of the call. This research aims to provide a better understanding of communication factors impacting on the accuracy and timeliness of ambulance dispatch. Methods and analysis A dataset of OHCA calls and their corresponding metadata will be analysed from an interdisciplinary perspective, combining linguistic analysis and health services research. The calls will be transcribed and coded for linguistic and interactional variables and then used to answer a series of research questions about the recognition of OHCA and the delivery of basic life-support instructions to bystanders. Linguistic analysis of calls will provide a deeper understanding of the interactional dynamics between caller and call-taker which may affect recognition and dispatch for OHCA. Findings from this research will translate into recommendations for modifications of the protocols for ambulance dispatch and provide directions for further research. Ethics and dissemination The study has been approved by the Curtin University Human Research Ethics Committee (HR128/2013) and the St John Ambulance Western Australia Research Advisory Group. Findings will be published in peer-reviewed journals and communicated to key audiences, including ambulance dispatch professionals. PMID:28694349

The use of self-determination theory to foster environmental motivation in an environmental biology course

NASA Astrophysics Data System (ADS)

Darner, Rebekka

A scientifically literate person is one who understands the nature of science, its processes, products, and their appropriate application to decision-making contexts. The impetus to make informed decisions about environmental issues is environmental motivation. I examined students' environmental motivation, its relationship to scientific knowledge, and how environmental motivation can be fostered in a science classroom. This study took place in a college-level environmental biology course in which the instructor attempted to support students' basic psychological needs, as defined by self-determination theory (SDT). The first question was to what extent does an SDT-guided environmental biology course differ from a non-SDT-guided course in the degree to which it fostered self-determined motivation toward the environment. The administration of a well-validated scale to two sections before, after, and six months following the end of the course indicated that SDT-guided instruction is a plausible way to foster environmental motivation in the classroom. The second question was what are the multiple influences on fostering self-determined motivation toward the environment in an SDT-guided course. Path analysis indicated that environmental motivation can be partially accomplished in an environmental biology course by conveying to students that they are cared for, are connected to others, and can trust others while solving environmental problems. The third question sought to characterize students' scientific conceptualizations as they solve environmental problems and the extent to which their conceptualizations relate to the satisfaction of their need for competence. Students were videotaped during in-class problem-solving, after which stimulated-recall interviews were conducted. Grounded theory and an established coding scheme were combined to analyze these data, which resulted in three grounded hypotheses about what characterizes students' scientific knowledge when they feel highly competent about solving environmental problems. The final research question sought to identify which classroom features students cite when they indicate that their basic psychological needs are being fulfilled or undermined. Grounded analysis resulted in seven features of the instructional environment. This dissertation marks the first application of SDT to a formal environmental education setting in which a goal was to foster environmental motivation. Several research prospects and a learning cycle based on findings are proposed.

The past is the key to the future

USGS Publications Warehouse

Doe, B.R.

1983-01-01

A new major frontier of geological research, which was initiated in the 1970's, involves predicting future geologic trends or events through study of the present and past, rather than trying to understand the past, often using what one knows about the present. Like most scientific frontiers, this one began from practical considerations-environmental concerns. The lack of formal recognition of this frontier results from fragmentation among many Federal agencies and highly focused mission-oriented programs (e.g., earthquake prediction, CO2, nuclear-energy safety, etc.). Most programs aim to predict only the next 50-100 years, but much longer periods of the past need to be studied to do this. Nuclear-waste disposal has sometimes been considered in terms of the next million years, a period of time permitting significant and broad geologic changes. Decreasing public interest in environmental concerns relegates many questions from the realm of applied research back to that of basic research. Most of these questions are so fascinating, however, that the frontier is still worth pursuing. Such questions include whether a phenomenon will or will not take place and the rates at which it can develop (e.g., how fast do rifts form, how fast can a caldera event begin, and how quickly can a glacial maximum arrive?). Common elements of all studies include the historic record, trends in the Quaternary, analogues in various periods of the geologic time scale, and allowance for phenomena never experienced before. Other examples of studies include the Cretaceous as a period of a climatic extreme, an especially interesting time period; establishing the amount of paleocloudiness, a particularly challenging and important research area; acid rain as a possible new phenomenon. Geochemistry has much to contribute to this frontier science. ?? 1983.

Patient-derived Xenograft (PDX) Models In Basic and Translational Breast Cancer Research

PubMed Central

Dobrolecki, Lacey E.; Airhart, Susie D.; Alferez, Denis G.; Aparicio, Samuel; Behbod, Fariba; Bentires-Alj, Mohamed; Brisken, Cathrin; Bult, Carol J.; Cai, Shirong; Clarke, Robert B.; Dowst, Heidi; Ellis, Matthew J.; Gonzalez-Suarez, Eva; Iggo, Richard D.; Kabos, Peter; Li, Shunqiang; Lindeman, Geoffrey J.; Marangoni, Elisabetta; McCoy, Aaron; Meric-Bernstam, Funda; Piwnica-Worms, Helen; Poupon, Marie-France; Reis-Filho, Jorge; Sartorius, Carol A.; Scabia, Valentina; Sflomos, George; Tu, Yizheng; Vaillant, François; Visvader, Jane E.; Welm, Alana; Wicha, Max S.

2017-01-01

Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational pre-clinical research. In breast cancer, to complement the now curated collection of approximately 45 long-established human breast cancer cell lines, a newly formed consortium of academic laboratories, currently from Europe, Australia, and North America, herein summarizes data on over 500 stably transplantable PDX models representing all three clinical subtypes of breast cancer (ER+, HER2+, and “Triple-negative” (TNBC)). Many of these models are well-characterized with respect to genomic, transcriptomic, and proteomic features, metastatic behavior, and treatment response to a variety of standard-of-care and experimental therapeutics. These stably transplantable PDX lines are generally available for dissemination to laboratories conducting translational research, and contact information for each collection is provided. This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, efforts to develop complementary data standards for annotation of PDX characteristics and biology, and progress toward “credentialing” of PDX models as surrogates to represent individual patients for use in pre-clinical and co-clinical translational research. In addition, this review highlights important unresolved questions, as well as current limitations, that have hampered more efficient generation of PDX lines and more rapid adoption of PDX use in translational breast cancer research. PMID:28025748

Harnessing neuroplasticity for clinical applications

PubMed Central

Sur, Mriganka; Dobkin, Bruce H.; O'Brien, Charles; Sanger, Terence D.; Trojanowski, John Q.; Rumsey, Judith M.; Hicks, Ramona; Cameron, Judy; Chen, Daofen; Chen, Wen G.; Cohen, Leonardo G.; deCharms, Christopher; Duffy, Charles J.; Eden, Guinevere F.; Fetz, Eberhard E.; Filart, Rosemarie; Freund, Michelle; Grant, Steven J.; Haber, Suzanne; Kalivas, Peter W.; Kolb, Bryan; Kramer, Arthur F.; Lynch, Minda; Mayberg, Helen S.; McQuillen, Patrick S.; Nitkin, Ralph; Pascual-Leone, Alvaro; Reuter-Lorenz, Patricia; Schiff, Nicholas; Sharma, Anu; Shekim, Lana; Stryker, Michael; Sullivan, Edith V.; Vinogradov, Sophia

2011-01-01

Neuroplasticity can be defined as the ability of the nervous system to respond to intrinsic or extrinsic stimuli by reorganizing its structure, function and connections. Major advances in the understanding of neuroplasticity have to date yielded few established interventions. To advance the translation of neuroplasticity research towards clinical applications, the National Institutes of Health Blueprint for Neuroscience Research sponsored a workshop in 2009. Basic and clinical researchers in disciplines from central nervous system injury/stroke, mental/addictive disorders, paediatric/developmental disorders and neurodegeneration/ageing identified cardinal examples of neuroplasticity, underlying mechanisms, therapeutic implications and common denominators. Promising therapies that may enhance training-induced cognitive and motor learning, such as brain stimulation and neuropharmacological interventions, were identified, along with questions of how best to use this body of information to reduce human disability. Improved understanding of adaptive mechanisms at every level, from molecules to synapses, to networks, to behaviour, can be gained from iterative collaborations between basic and clinical researchers. Lessons can be gleaned from studying fields related to plasticity, such as development, critical periods, learning and response to disease. Improved means of assessing neuroplasticity in humans, including biomarkers for predicting and monitoring treatment response, are needed. Neuroplasticity occurs with many variations, in many forms, and in many contexts. However, common themes in plasticity that emerge across diverse central nervous system conditions include experience dependence, time sensitivity and the importance of motivation and attention. Integration of information across disciplines should enhance opportunities for the translation of neuroplasticity and circuit retraining research into effective clinical therapies. PMID:21482550

Musculoskeletal discipline science plan

NASA Technical Reports Server (NTRS)

1991-01-01

Life sciences research in the musculoskeletal discipline must identify possible consequences of weightlessness on this system, understand the mechanisms of these effects, and develop effective and operationally practical countermeasures to protect crewmembers. The musculoskeletal system is highly plastic in that is possesses the inherent capability to adapt its structural and functional properties in accordance with the type and degree of stimuli imposed on it. Prolonged space travel is essentially a period of significant unloading of the musculoskeletal system. This results in adaptive responses in the structure and function of this system, placing it on the low end of a continuum from one of complete disuse to one of maximal use. There is a high probability that the musculoskeletal system is functionally impaired with increasing duration of weightlessness. The purpose of this Discipline Science Plan is to provide a conceptual strategy for NASA's Life Sciences division research and development activities in the area of musculoskeletal function. This document summarizes the current status of the program, outlines available knowledge, establishes goals and objectives, identifies science priorities, and defines research opportunities, which encompass critical questions in the subdiscipline areas (e.g., muscle, bone, and other musculoskeletal connective tissues). These science activities include ground-based and flight; basic, applied, and operational; and animal and human research and development. This document contains a general plan that will be used by both NASA Headquarters Program Offices and the field centers to review and plan basic, applied, and operational intramural and extramural research and development activities in this area.

Tooth wear and erosion: methodological issues in epidemiological and public health research and the future research agenda.

PubMed

Ganss, C; Young, A; Lussi, A

2011-09-01

This paper addresses methodological issues in the field of tooth wear and erosion research including the epidemiological indices, and identifies future work that is needed to improve knowledge about tooth wear and erosion. The paper is result of the work done at the meetings of the Special Interest Group "Tooth Surface Loss and Erosion" at the 2008, 2009 and 2010 conferences of the European Association for Dental Public Health, and the Workshop "Current Erosion indices- flawed or valid" which took place in Basel in 2007. Although there is consensus about the definition and the diagnostic criteria of various forms of tooth wear, gaps in research strategies have been identified. A basic problem is that fundamental concepts of wear and erosion as an oral health problem, have not yet been sufficiently defined. To a certain extent, tooth wear is a physiological condition, and there is no consensus as to whether it can be regarded as a disease. Furthermore, the multitude of indices and flaws in existing indices, make published data difficult to interpret. Topics for the research agenda are: the initiation of a consensus process towards an internationally accepted index, and the initiation of data collection on the prevalence of various forms of wear on a population-based level. There should be an emphasis on promoting communication between basic and clinical sciences, and the area of Public Health Dentistry. Furthermore, the question of whether tooth wear is a public health problem remains open for debate.

Incorporation of basic research and service components in a field environmental geochemistry course

NASA Astrophysics Data System (ADS)

Senko, J.

2015-12-01

"Application-based service learning" (ABSL) refers to an approach to formal course instruction that integrates service and research components into the course. An ABSL approach was employed in a field-based environmental chemistry course, whose goal was to evaluate and monitor the aqueous geochemistry of coal mine-derived acid mine drainage (AMD) in the Appalachia basin. In this course, students conducted literature reviews on the geochemistry and environmental impacts of AMD, participated in a field sampling campaign of several AMD treatment systems, and conducted chemical analyses of the samples that they retrieved. The remainder of the course was dedicated to "lab meetings," during which data was analyzed, conclusions were drawn from the data, and a manuscript was drafted that described the findings of the field analyses, and made recommendations regarding the performance of the AMD treatment systems. The service component of the course focused on socioeconomic impacts of coal mining and the Appalachian region, with the final manuscript distributed to AMD treatment practitioners and state regulatory agencies. A comparison of pre- and post-course questionnaires that included Likert scale questions revealed that students' attitudes toward basic research improved over the period or the course. Based on the questionnaires attitudes toward service diminished, but "open-ended" questionnaires indicated an improved attitude toward both research and service, with an emphasis on the benefits of research that serves the community. Ultimately, we hope to develop approaches to compare the effectiveness of ABSL-based across disciplines.

Conceptual Mobility and Entrenchment in Introductory Geoscience Courses: New Questions Regarding Physics' and Chemistry's Role in Learning Earth Science Concepts

ERIC Educational Resources Information Center

Anderson, Steven W.; Libarkin, Julie C.

2016-01-01

Nationwide pre- and posttesting of introductory courses with the Geoscience Concept Inventory (GCI) shows little gain for many of its questions. Analysis of more than 3,500 tests shows that 22 of the 73 GCI questions had gains of <0.03, and nearly half of these focused on basic physics and chemistry. We also discovered through an assessment of…

Basic Training for Skill Development.

ERIC Educational Resources Information Center

B.T.S.D. Review, 1974

1974-01-01

Profound changes in our socioeconomic structure seem to question the relevance of both "institutional" as well as "open school" forms of education. The educator is faced with the challenge of selecting a model, combining models, or devising a new one. Dealing with these fundamental questions, 10 articles have been selected for their potential…

Unionizing: A Guide for Child Care Workers.

ERIC Educational Resources Information Center

Whitebook, Marcy; And Others

Including excerpts from contracts protecting unionized child care workers, this booklet explains basic terminology and facts about unionizing and addresses child care workers' concerns. Section 1 answers commonly asked questions about unions and offers advice about how to answer parents' questions about workers' attempts to organize. Section 2…

A Not so Trivial Pursuit.

ERIC Educational Resources Information Center

Magahay-Johnson, Wendy

1985-01-01

Describes procedures for designing trivia games to be used in teaching English as a second language. The students participate in designing the games, thereby gaining practice in the four basic language skills and the formation of yes-no questions, information questions, and statements. Provides examples for young intermediate ESL students. (SED)

The Semantic-Pragmatics Interface and Island Constraints in Chinese

ERIC Educational Resources Information Center

Jin, Dawei

2016-01-01

This thesis is about strong island effects and intervention effects. Strong island effects are contexts where operator-variable dependencies cannot be established. The paradigmatic cases of strong island violations in Chinese occur in "why"-questions. This thesis explores a basic contrast: "why"-questions fail to be interpreted…

Science 101: Can Electromagnetic Waves Affect Emotions?

ERIC Educational Resources Information Center

Robertson, Bill

2017-01-01

The answer to this month's question, "Can electromagnetic waves affect emotions," is yes. Wherever there are electromagnetic (EM) waves (basically everywhere!), there is the potential for them directly or indirectly to affect the emotions. But what about the likely motivation behind the originally-posed question? Can EM waves affect your…

Accessing Programs for Infants, Toddlers, and Preschoolers with Disabilities.

ERIC Educational Resources Information Center

Horne, Richard, Ed.

1990-01-01

Intended for use by parents of infants, toddlers and preschoolers, this guide presents, in question and answer format, basic information about early intervention and special education services. Questions about services for the period from birth through 2 years include the following: "What are early intervention services?""What is an…

Exploring Undergraduates' Understanding of Photosynthesis Using Diagnostic Question Clusters

ERIC Educational Resources Information Center

Parker, Joyce M.; Anderson, Charles W.; Heidemann, Merle; Merrill, John; Merritt, Brett; Richmond, Gail; Urban-Lurain, Mark

2012-01-01

We present a diagnostic question cluster (DQC) that assesses undergraduates' thinking about photosynthesis. This assessment tool is not designed to identify individual misconceptions. Rather, it is focused on students' abilities to apply basic concepts about photosynthesis by reasoning with a coordinated set of practices based on a few scientific…

Evaluation of the Triple Code Model of numerical processing-Reviewing past neuroimaging and clinical findings.

PubMed

Siemann, Julia; Petermann, Franz

2018-01-01

This review reconciles past findings on numerical processing with key assumptions of the most predominant model of arithmetic in the literature, the Triple Code Model (TCM). This is implemented by reporting diverse findings in the literature ranging from behavioral studies on basic arithmetic operations over neuroimaging studies on numerical processing to developmental studies concerned with arithmetic acquisition, with a special focus on developmental dyscalculia (DD). We evaluate whether these studies corroborate the model and discuss possible reasons for contradictory findings. A separate section is dedicated to the transfer of TCM to arithmetic development and to alternative accounts focusing on developmental questions of numerical processing. We conclude with recommendations for future directions of arithmetic research, raising questions that require answers in models of healthy as well as abnormal mathematical development. This review assesses the leading model in the field of arithmetic processing (Triple Code Model) by presenting knowledge from interdisciplinary research. It assesses the observed contradictory findings and integrates the resulting opposing viewpoints. The focus is on the development of arithmetic expertise as well as abnormal mathematical development. The original aspect of this article is that it points to a gap in research on these topics and provides possible solutions for future models. Copyright © 2017 Elsevier Ltd. All rights reserved.

Disturbed soil characterization workshop: post-meeting summary

NASA Astrophysics Data System (ADS)

Cathcart, J. Michael

2010-04-01

Disturbance of ground surfaces can arise from a variety of processes, both manmade and natural. Burying landmines, vehicle movement, and walking are representative examples of processes that disturb ground surfaces. The nature of the specific disturbance process can lead to the observables that can aid the detection and identification of that process. While much research has been conducted in this area, fundamental questions related to the remote detection and characterization of disturbed soil surfaces remain unanswered. Under the sponsorship of the Army Research Office (ARO), the Night Vision and Electronic Sensors Directorate (NVESD), and the U.S. Army Corps of Engineers (USACE) Engineering Research and Development Center (ERDC), Georgia Tech hosted a workshop to address Remote Sensing Methods for Disturbed Soil Characterization. The workshop was held January 15-17, 2008 in Atlanta. The primary objective of this workshop was to take a new look at the disturbed soil problem in general as well as its relation to buried explosive detection and other manmade disturbances. In particular, the participants sought to outline the basic science and technology questions that need to be addressed across the full spectrum of military applications to fully exploit this phenomenon. This presentation will outline the approach taken during the workshop and provide a summary of the conclusions.

Small watershed-scale research and the challenges ahead

NASA Astrophysics Data System (ADS)

Larsen, M. C.; Glynn, P. D.

2008-12-01

For the past century, Federal mission science agencies (eg. USFS, NRCS, ARS, USGS) have had the long- term agency goals, infrastructure, and research staff to conduct research and data collection in small watersheds as well as support these activities for non-Federal partners. The National Science Foundation has been a strong partner with the Federal mission science agencies, through the LTER network, which is dependent on Federally supported research sites, and more recently with the emerging CUAHSI, WATERS, CZEN, and NEON initiatives. Much of the NSF-supported research builds on the foundations provided by their Federally supported partners, who sustain the long-term, extensive monitoring activity and research sites, including making long-term data available to all users via public interfaces. The future of these programs, and their enhancement/expansion to face the intensifying concurrent challenges of population growth, land-use change, and climate change, is dependent on a well-funded national commitment to basic science. Such a commitment will allow the scientific community to advance our understanding of these scientific challenges and to synthesize our understanding among research sites and at the national scale. Small watersheds serve as essential platforms where hypotheses can be tested, as sentinels for climate change, and as a basis for comparing and scaling up local information and syntheses to regional and continental scales. The science guides resource management and mitigation decisions and is fundamental to the development of predictive models. Furthermore, small-watershed research and monitoring programs are generally undervalued because many research questions that can be addressed now or in the future were not anticipated when the sites were initiated. Some examples include: 1) the quantification, characterization, and understanding of how emerging contaminants, personal care products, and endocrine disruptors affect organisms - substances that could not be detected until the recent increased sensitivity of modern techniques; 2) the recognition of changing climate and its effects on already-stressed water resources and ecosystems; 3) more integrated monitoring and modeling of ecosystem processes and quantification of ecosystem services. Historical hydrological and biogeochemical information available at USGS and other watershed-research and -monitoring sites can now be used in conjunction with active monitoring of biota and biological processes (especially those involving plants, invertebrates and microbes). The results will help provide a more nationally consistent framework for evaluating ecosystem health, and assessing ecosystem services, in the face of changing climate and land-use. These, and related science questions and societal issues are complex and require strong collaborations across disciplinary and organizational boundaries. Along with a well-funded national commitment to basic watershed research, the USGS continually seeks to strengthen its small-watershed and ecosystem-science programs through partnerships with NSF, State, and Federal agencies. Given the growing U.S. population, continual development in water-scarce regions, and general water- and soil-resource stress under competing national interests and priorities, the role of basic watershed-scale research and monitoring is essential because of its unique niche in the development of the improved environmental understanding and predictive models needed by resource managers.

Use of olivine and plagioclase saturation surfaces for the petrogenetic modeling of recrystallized basic plutonic systems

NASA Technical Reports Server (NTRS)

Hanson, G. N.

1983-01-01

During petrogenetic studies of basic plutonic rocks, there are at least three major questions to be considered: (1) what were the relative proportions of cumulate crystals and intercumulus melt in a given sample? (2) what is the composition and variation in composition of the melts within the pluton? and (3) what is the original composition of the liquids, their source and evolution prior to the time of emplacement? Use of both saturation surfaces can place strong limits on the compositions of potential cumulate phases and intercumulus melts. Consideration of appropriate trace elements can indicate whether a sample is an orthocumulate, adcumulate or mesocumulate. Thus, when trace element and petrographic data are considered together with the saturation surfaces, it should be possible to begin to answer the three major questions given above, even for strongly recrystallized basic plutons.

The ethics of complexity. Genetics and autism, a literature review.

PubMed

Hens, Kristien; Peeters, Hilde; Dierickx, Kris

2016-04-01

It is commonly believed that the etiology of autism is at least partly explained through genetics. Given the complexity of autism and the variability of the autistic phenotype, genetic research and counseling in this field are also complex and associated with specific ethical questions. Although the ethics of autism genetics, especially with regard to reproductive choices, has been widely discussed on the public fora, an in depth philosophical or bioethical reflection on all aspects of the theme seems to be missing. With this literature review we wanted to map the basic questions and answers that exist in the bioethical literature on autism genetics, research, counseling and reproduction, and provide suggestions as to how the discussion can proceed. We found 19 papers that fitted the description of "bioethics literature focusing on autism genetics," and analyzed their content to distill arguments and themes. We concluded that because of the complexity of autism, and the uncertainty with regard to its status, more ethical reflection is needed before definite conclusions and recommendations can be drawn. Moreover, there is a dearth of bioethical empirical studies querying the opinions of all parties, including people with autism themselves. Such empirical bioethical studies should be urgently done before bioethical conclusions regarding the aims and desirability of research into autism genes can be done. Also, fundamental philosophical reflection on concepts of disease should accompany research into the etiology of autism. © 2016 Wiley Periodicals, Inc.

"The NASA Solar System Exploration n Research Vistula Institute: Year 1 with New Teams with New and Old Partners!"

NASA Astrophysics Data System (ADS)

Daou, Doris

2015-08-01

Recognizing that science enables exploration, and exploration enables science, NASA created the Solar System Exploration Research Virtual Institute (SSERVI) to address basic and applied scientific questions fundamental to understanding the Moon, Near Earth Asteroids, and the moons of Mars. Primarily using virtual tools to communicate has eliminated the need for a traditional bricks and mortar institute, allowing the hundreds of researchers across the U.S. and the eight international partners to easily communicate and collaborate, from wherever they are. The small, central office located at NASA Ames Research Center in the heart of Silicon Valley, coordinates the institute activities. Newly found synergies across the teams, the sharing of data and facilities, and the ease of communication increase the efficiencies of scientific discovery. More importantly, the birth of ideas formed at the intersection of disparate disciplines can readily be pursued by groups that might not otherwise have formed, or even met! SSERVI follows on the heels of the highly successful NASA Lunar Science Institute (NLSI), a virtual institute dedicated solely to studies of the Moon. The creation of SSERVI has not only expanded our knowledge of the Earth’s nearest neighbor to include other stepping-stones to Mars, but also furthered our ability to address the scientific and technological questions we need to know…before we go!

Cleft Palate-Craniofacial Journal 50th anniversary editorial board commentary: anatomy, basic sciences, and genetics--then and now.

PubMed

Mooney, Mark P; Cooper, Gregory M; Marazita, Mary L

2014-05-01

To celebrate the 50th year of the Cleft Palate-Craniofacial Journal we look back to where we started in 1964 and where we are now, and we speculate about directions for the future in a "Then and Now" editorial series. This editorial examines changing trends and perspectives in anatomical, basic science, and genetic studies published in this 50-year interval. In volume 1 there were 45 total papers, seven (16%) of which were peer-reviewed basic science and genetic articles published: four in anatomy, three in craniofacial biology, and none in genetics. In contrast, in volume 50, of 113 articles there were 47 (42%) peer-reviewed basic science and genetic articles published: 30 in anatomy, five in craniofacial biology, and 12 in genetics. Topical analysis of published manuscripts then and now reveal that similar topics in anatomy and craniofacial biology are still being researched today (e.g., phenotypic variability, optimal timing of surgery, presurgical orthopedics, bone grafting); whereas, most of the more recent papers use advanced technology to address old questions. In contrast, genetic publications have clearly increased in frequency during the last 50 years, which parallels advances in the field during this time. However, all of us have noticed that the more "cutting-edge" papers in these areas are not being submitted for publication to the journal, but instead to discipline-specific journals. Concerted efforts are therefore indicated to attract and publish these cutting-edge papers in order to keep the Cleft Palate-Craniofacial Journal in the forefront of orofacial cleft and craniofacial anomaly research and to provide a valuable service to American Cleft Palate-Craniofacial Association members.

Space Rocks Tell Their Secrets: Space Science Applications of Physics and Chemistry for High School and College Classes

NASA Technical Reports Server (NTRS)

Lindstrom, M. M.; Tobola, K. W.; Stocco, K.; Henry, M.; Allen, J. S.

2003-01-01

As the scientific community studies Mars remotely for signs of life and uses Martian meteorites as its only available samples, teachers, students, and the general public continue to ask, "How do we know these meteorites are from Mars?" This question sets the stage for a three-lesson instructional package Space Rocks Tell Their Secrets. Expanding on the short answer "It's the chemistry of the rock", students are introduced to the research that reveals the true identities of the rocks. Since few high school or beginning college students have the opportunity to participate in this level of research, a slide presentation introduces them to the labs, samples, and people involved with the research. As they work through the lessons and interpret real data, students realize that the research is an application of basic science concepts they should know, the electromagnetic spectrum and isotopes. They can understand the results without knowing how to do the research or operate the instruments.