Science.gov

Sample records for basis entwicklung schneller

  1. Nutzergerechte Entwicklung der Mensch-Maschine-Interaktion von Fahrerassistenzsystemen

    NASA Astrophysics Data System (ADS)

    König, Winfried

    Durch langjährige Forschungen bei Kfz-Herstellern, Zulieferfirmen und an Hochschulen sind umfangreiche, aber dennoch lückenhafte Erkenntnisse über das Zusammenspiel zwischen FAS und Nutzer gewonnen worden. In deutschen und internationalen Projekten wie z. B. PROMETHEUS, DRIVE, MOTIV, INVENT, RESPONSE und AKTIV haben sich Kfz-Hersteller, Zulieferfirmen, Hochschulen und weitere staatliche und private Forschungseinrichtungen zusammengefunden, um die vorwettbewerbliche Forschung für derartige Systeme voranzutreiben. Im folgenden Kapitel sollen einige der gewonnenen Kenntnisse dargelegt werden, um die Entwicklung des HMI von FAS zu erleichtern.

  2. International Seminar on Curriculum Development for Basic Education Programmes. (Berlin, West Germany, June 12-21, 1978). Final Report. DSE [Deutsche Stiftung fur internationale Entwicklung] Report.

    ERIC Educational Resources Information Center

    Kahler, David, Ed.

    This report presents the proceedings of a 1978 international seminar held in Berlin which was convened by the German Foundation for International Development (Deutsche Stiftung fur internationale Entwicklung) in cooperation with Teheran's International Institute for Adult Literacy Methods. The designated purpose of the seminar was to examine…

  3. Die Kometen der Jahre 1531 bis 1539 und ihre Bedeutung für die spätere Entwicklung der Kometenforschung.

    NASA Astrophysics Data System (ADS)

    Kokott, W.

    Contents: 1. Historisches Umfeld und spätere Entwicklungen. 2. Kometen als Objekte quantitativer Beobachtung im geschlossenen Universum der Epoche. 3. Verlauf der Kometenerscheinungen der Jahre 1531 bis 1539. 4. Die Bedeutung der Kometen der Jahre 1531 bis 1539 für die Entwicklung der Astronomie bis Tycho Brahe und für die Kometentheorie späterer Jahrhunderte. 5. Neuere Literatur und Spezialprobleme.

  4. The Basis System

    SciTech Connect

    Dubois, P.F.

    1989-05-16

    This paper discusses the basis system. Basis is a program development system for scientific programs. It has been developed over the last five years at Lawrence Livermore National Laboratory (LLNL), where it is now used in about twenty major programming efforts. The Basis System includes two major components, a program development system and a run-time package. The run-time package provides the Basis Language interpreter, through which the user does input, output, plotting, and control of the program's subroutines and functions. Variables in the scientific packages are known to this interpreter, so that the user may arbitrarily print, plot, and calculate with, any major program variables. Also provided are facilities for dynamic memory management, terminal logs, error recovery, text-file i/o, and the attachment of non-Basis-developed packages.

  5. Safety Basis Report

    SciTech Connect

    R.J. Garrett

    2002-01-14

    As part of the internal Integrated Safety Management Assessment verification process, it was determined that there was a lack of documentation that summarizes the safety basis of the current Yucca Mountain Project (YMP) site characterization activities. It was noted that a safety basis would make it possible to establish a technically justifiable graded approach to the implementation of the requirements identified in the Standards/Requirements Identification Document. The Standards/Requirements Identification Documents commit a facility to compliance with specific requirements and, together with the hazard baseline documentation, provide a technical basis for ensuring that the public and workers are protected. This Safety Basis Report has been developed to establish and document the safety basis of the current site characterization activities, establish and document the hazard baseline, and provide the technical basis for identifying structures, systems, and components (SSCs) that perform functions necessary to protect the public, the worker, and the environment from hazards unique to the YMP site characterization activities. This technical basis for identifying SSCs serves as a grading process for the implementation of programs such as Conduct of Operations (DOE Order 5480.19) and the Suspect/Counterfeit Items Program. In addition, this report provides a consolidated summary of the hazards analyses processes developed to support the design, construction, and operation of the YMP site characterization facilities and, therefore, provides a tool for evaluating the safety impacts of changes to the design and operation of the YMP site characterization activities.

  6. Neuromechanical Basis of Kinesiology.

    ERIC Educational Resources Information Center

    Enoka, Roger M.

    This textbook provides a scientific basis for the study of human motion. The eight chapters are organized under three major sections. Part One--The Force-Motion Relationship--contains chapters on (1) motion; (2) force; (3) types of movement analysis. In Part Two--The Simple Joint System--chapters concern (4) simple joint system components; (5)…

  7. Neuromechanical Basis of Kinesiology.

    ERIC Educational Resources Information Center

    Enoka, Roger M.

    This textbook provides a scientific basis for the study of human motion. The eight chapters are organized under three major sections. Part One--The Force-Motion Relationship--contains chapters on (1) motion; (2) force; (3) types of movement analysis. In Part Two--The Simple Joint System--chapters concern (4) simple joint system components; (5)…

  8. Frauen, Bildung und Entwicklung

    NASA Astrophysics Data System (ADS)

    Nestvogel, Renate

    1987-12-01

    The author presents first steps towards a development-based concept of women's education in the industrialized countries. Some elements of this concept are: (1) planning and action in a global context, (2) the local or regional bias given to education, (3) promotion of an intercultural perspective, (4) reducing the power of structures that encourage oppression. The author's observations are based on the following propositions: the `development process' in the industrialized countries has had terrible effects all over the world and it is necessary that women also consider their roles in what the author considers to be a process of destruction. This is because women are part of the overall system and contribute to its perpetuation in the measure of their own socialization. Connections are established between the destruction of the environment and the individual, as also between the victims and assailants of racism and sexism with a view to clarifying unidentified parts of the female consciousness. Beyond this, the role of European women in the context of colonialism and the present contact between European women and their counterparts from other cultures are examined with particular attention being paid to the exercise of power and force in the family and society.

  9. Radioactive Waste Management Basis

    SciTech Connect

    Perkins, B K

    2009-06-03

    The purpose of this Radioactive Waste Management Basis is to describe the systematic approach for planning, executing, and evaluating the management of radioactive waste at LLNL. The implementation of this document will ensure that waste management activities at LLNL are conducted in compliance with the requirements of DOE Order 435.1, Radioactive Waste Management, and the Implementation Guide for DOE Manual 435.1-1, Radioactive Waste Management Manual. Technical justification is provided where methods for meeting the requirements of DOE Order 435.1 deviate from the DOE Manual 435.1-1 and Implementation Guide.

  10. Structural basis of aspartylglucosaminuria

    SciTech Connect

    Saito, Seiji; Ohno, Kazuki; Sugawara, Kanako; Suzuki, Toshihiro; Togawa, Tadayasu; Sakuraba, Hitoshi

    2008-12-26

    To elucidate the basis of aspartylglucosaminuria (AGU) from the viewpoint of enzyme structure, we constructed structural models of mutant aspartylglucosaminidase (AGA) proteins using molecular modeling software, TINKER. We classified the amino acid substitutions responsible for AGU and divided them into three groups based on the biochemical phenotype. Then, we examined the structural changes in the AGA protein for each group by calculating the solvent-accessible surface area (ASA), the number of atoms affected, and the root-mean-square deviation (RMSD). Our results revealed that the structural changes in group 1, which exhibits folding/transport defects and a complete deficiency of AGA activity, were generally large and located in the core region of the enzyme molecule. In group 2, exhibiting the mature AGA protein but no AGA activity, the functionally important region of the enzyme molecule was seriously affected. In group 3 exhibiting residual AGA activity, the structural changes in AGA were small and localized near the surface of the enzyme molecule. Coloring of affected atoms based on the distances between the wild-type and mutant ones revealed the characteristic structural changes in the AGA protein geographically and semi-quantitatively. Structural investigation provides us with a deeper insight into the basis of AGU.

  11. WEST Physics Basis

    NASA Astrophysics Data System (ADS)

    Bourdelle, C.; Artaud, J. F.; Basiuk, V.; Bécoulet, M.; Brémond, S.; Bucalossi, J.; Bufferand, H.; Ciraolo, G.; Colas, L.; Corre, Y.; Courtois, X.; Decker, J.; Delpech, L.; Devynck, P.; Dif-Pradalier, G.; Doerner, R. P.; Douai, D.; Dumont, R.; Ekedahl, A.; Fedorczak, N.; Fenzi, C.; Firdaouss, M.; Garcia, J.; Ghendrih, P.; Gil, C.; Giruzzi, G.; Goniche, M.; Grisolia, C.; Grosman, A.; Guilhem, D.; Guirlet, R.; Gunn, J.; Hennequin, P.; Hillairet, J.; Hoang, T.; Imbeaux, F.; Ivanova-Stanik, I.; Joffrin, E.; Kallenbach, A.; Linke, J.; Loarer, T.; Lotte, P.; Maget, P.; Marandet, Y.; Mayoral, M. L.; Meyer, O.; Missirlian, M.; Mollard, P.; Monier-Garbet, P.; Moreau, P.; Nardon, E.; Pégourié, B.; Peysson, Y.; Sabot, R.; Saint-Laurent, F.; Schneider, M.; Travère, J. M.; Tsitrone, E.; Vartanian, S.; Vermare, L.; Yoshida, M.; Zagorski, R.; Contributors, JET

    2015-06-01

    With WEST (Tungsten Environment in Steady State Tokamak) (Bucalossi et al 2014 Fusion Eng. Des. 89 907-12), the Tore Supra facility and team expertise (Dumont et al 2014 Plasma Phys. Control. Fusion 56 075020) is used to pave the way towards ITER divertor procurement and operation. It consists in implementing a divertor configuration and installing ITER-like actively cooled tungsten monoblocks in the Tore Supra tokamak, taking full benefit of its unique long-pulse capability. WEST is a user facility platform, open to all ITER partners. This paper describes the physics basis of WEST: the estimated heat flux on the divertor target, the planned heating schemes, the expected behaviour of the L-H threshold and of the pedestal and the potential W sources. A series of operating scenarios has been modelled, showing that ITER-relevant heat fluxes on the divertor can be achieved in WEST long pulse H-mode plasmas.

  12. CMAC with General Basis Functions.

    PubMed

    Chun-Shin, Lin; Ching-Tsan, Chiang

    1996-10-01

    The cerebellar model articulation controller (CMAC) is often used in learning control. It can be viewed as a basis function network (BFN). The conventional CMAC uses local constant basis functions. A disadvantage is that its output is constant within each quantized state and the derivative information is not preserved. If the constant basis functions are replaced by non-constant differentiable basis functions, the derivative information will be able to be stored into the structure as well. In this paper, the generalized scheme that uses general basis functions is investigated. The conventional CMAC is a special case of the generalized technique. The mathematical foundation for the modified scheme is derived and the convergence of learning is proved. Simulations for the CMAC with Gaussian basis functions (GBFs) are performed to demonstrate the improvement of accuracy in modeling, and the capability in providing derivative information. Copyright 1996 Elsevier Science Ltd

  13. GASB's Basis of Accounting Project.

    ERIC Educational Resources Information Center

    Kovlak, Daniel L.

    1986-01-01

    In July 1984, the Governmental Accounting Standards Board began its "Measurement Focus/Basis of Accounting" project, which addresses measurement issues and revenue and expenditure recognition problems involving governmental funds. This article explains the project's background, alternatives discussed by the board, and tentative…

  14. A Molecular Basis of Cancer.

    ERIC Educational Resources Information Center

    Weinberg, Robert A.

    1983-01-01

    Discusses the molecular basis of cancer, focusing on genetics of the disease. Indicates that human cancers are initiated by oncogenes (altered versions of normal genes) and that in one case the critical alteration is a single point mutation that changes one amino acid in the protein encoded by the gene. (JN)

  15. Grobner Basis Representations of Sudoku

    ERIC Educational Resources Information Center

    Taalman, Laura; Arnold, Elizabeth; Lucas, Stephen

    2010-01-01

    This paper uses Grobner bases to explore the inherent structure of Sudoku puzzles and boards. In particular, we develop three different ways of representing the constraints of Sudoku puzzles with a system of polynomial equations. In one case, we explicitly show how a Grobner basis can be used to obtain a more meaningful representation of the…

  16. A Molecular Basis of Cancer.

    ERIC Educational Resources Information Center

    Weinberg, Robert A.

    1983-01-01

    Discusses the molecular basis of cancer, focusing on genetics of the disease. Indicates that human cancers are initiated by oncogenes (altered versions of normal genes) and that in one case the critical alteration is a single point mutation that changes one amino acid in the protein encoded by the gene. (JN)

  17. Complete Basis Set Model Chemistries

    NASA Astrophysics Data System (ADS)

    Ochterski, Joseph Wallace

    1994-01-01

    The major source of error in most ab initio calculations of molecular energies is the truncation of the one-electron basis set. Extrapolation to the complete basis set second -order (CBS2) limit using the N^{-1 } asymptotic convergence of N-configuration pair natural orbital (PNO) expansions can be combined with the use of relatively small basis sets for the higher-order correlation energy to develop cost effective computational models. Following this strategy, four new computational models denoted CBS-4, CBS-q, CBS-Q, and CBS-QCI/APNO are introduced. The mean absolute deviations (MAD) from experiment for the 125 energies of the G2 test set are 2.0, 1.7, 1.0 and 0.5 kcal/mol, respectively. The error distributions for all six models are indistinguishable from Gaussian distribution functions. Calculations on the cyclopropenyl radical and cyclopropenylidene provide new dissociation energies which are in accord with an interpretation of the thermochemistry emphasizing aromaticity. Several levels of theory are examined as candidates for the routine calculation of molecular geometries. The very simple UHF/3-21G* model gives bond lengths to an accuracy of +/-0.027 A compared with experiment for a test set of 69 small molecules. The commonly used MP2/6-31G* model (RMS error 0.025 A) offers virtually no improvement and use of the considerably more expensive QCISD calculations with the same basis set provides only a modest reduction to 0.020 A. However, spin projected MP3 calculations with a modified basis set including f -functions on Si, P, S, and Cl, reduce the RMS error to 0.010 A. This PMP3/6-31Gdf* model is recommended as a general scheme of geometry optimization for small molecules. The equilibrium structure and binding energy of the water dimer have been determined for several levels of ab initio theory. The basis set convergence of the SCF energy, the intramolecular and intermolecular MP2 energy, and higher-order effects, are examined separately and realistic error

  18. Perceptual basis for reactive teleoperation

    NASA Astrophysics Data System (ADS)

    Park, Young S.; Ewing, Thomas F.; Boyle, James M.; Yule, Thomas J.

    2001-10-01

    To improve task performance in partially structured environments, enhancements to teleoperation have been proposed by introducing autonomous behaviors. Such autonomy is implemented based on a reactive robotic architecture, where reactive motor agents that directly couple sensory inputs and motor actions become the building blocks. To this end, a perceptual basis for the motor agents is presented in this paper. The perceptual basis consists of perceptual agents that extract environmental information from a structured light vision system and provide action-oriented perception for the corresponding motor agents. Rather than performing general scene reconstruction, a perceptual agent directly provides the motion reference for the motor behavior. Various sensory mechanisms - sensor fission, fusion, and fashion - become basic building blocks of the perception process. Since perception is a process deeply intertwined with the motor actions, active perception may also incorporate motor behaviors as an integral perceptual process.

  19. Perceptual basis for reactive teleoperation.

    SciTech Connect

    Park, Y. S.; Ewing, T. F.; Boyle, J. M.; Yule, T. J.

    2001-08-28

    To enhance task performance in partially structured environment, enhancement of teleoperation was proposed by introducing autonomous behaviors. Such autonomy is implemented based on reactive robotic architecture, where reactive motor agents that directly couples sensory inputs and motor actions become the building blocks. To this end, presented in this paper is a perceptual basis for the motor agents. The perceptual basis consists of perceptual agents that extracts environmental information from a structured light vision system and provide action oriented perception for the corresponding motor agents. Rather than performing general scene reconstruction, a perceptual agent directly provides the motion reference for the motor behavior. Various sensory mechanisms--sensor fission, fusion, and fashion--becomes basic building blocks of the perception process. Since perception is a process deeply intertwined with the motor actions, active perception may also incorporate motor behaviors as an integral perceptual process.

  20. Authorization basis requirements comparison report

    SciTech Connect

    Brantley, W.M.

    1997-08-18

    The TWRS Authorization Basis (AB) consists of a set of documents identified by TWRS management with the concurrence of DOE-RL. Upon implementation of the TWRS Basis for Interim Operation (BIO) and Technical Safety Requirements (TSRs), the AB list will be revised to include the BIO and TSRs. Some documents that currently form part of the AB will be removed from the list. This SD identifies each - requirement from those documents, and recommends a disposition for each to ensure that necessary requirements are retained when the AB is revised to incorporate the BIO and TSRs. This SD also identifies documents that will remain part of the AB after the BIO and TSRs are implemented. This document does not change the AB, but provides guidance for the preparation of change documentation.

  1. TCAP Aluminium Dissolution Flowsheet Basis

    SciTech Connect

    PIERCE, ROBERTA.

    2004-03-01

    The Actinide Technology Section has proposed the use of an nitric acid HNO3 and potassium fluoride KF flowsheet for stripping palladium Pd from palladium-coated kieselguhr Pd/K and removing aluminum (Al) metal foam from the TCAP coils. The basis for the HNO3-KF flowsheet is drawn from many sources. A brief review of the sources will be presented. The basic flowsheet involves three process steps, each with its own chemistry.

  2. Hanford Generic Interim Safety Basis

    SciTech Connect

    Lavender, J.C.

    1994-09-09

    The purpose of this document is to identify WHC programs and requirements that are an integral part of the authorization basis for nuclear facilities that are generic to all WHC-managed facilities. The purpose of these programs is to implement the DOE Orders, as WHC becomes contractually obligated to implement them. The Hanford Generic ISB focuses on the institutional controls and safety requirements identified in DOE Order 5480.23, Nuclear Safety Analysis Reports.

  3. Performance Basis for Airborne Separation

    NASA Technical Reports Server (NTRS)

    Wing, David J.

    2008-01-01

    Emerging applications of Airborne Separation Assistance System (ASAS) technologies make possible new and powerful methods in Air Traffic Management (ATM) that may significantly improve the system-level performance of operations in the future ATM system. These applications typically involve the aircraft managing certain components of its Four Dimensional (4D) trajectory within the degrees of freedom defined by a set of operational constraints negotiated with the Air Navigation Service Provider. It is hypothesized that reliable individual performance by many aircraft will translate into higher total system-level performance. To actually realize this improvement, the new capabilities must be attracted to high demand and complexity regions where high ATM performance is critical. Operational approval for use in such environments will require participating aircraft to be certified to rigorous and appropriate performance standards. Currently, no formal basis exists for defining these standards. This paper provides a context for defining the performance basis for 4D-ASAS operations. The trajectory constraints to be met by the aircraft are defined, categorized, and assessed for performance requirements. A proposed extension of the existing Required Navigation Performance (RNP) construct into a dynamic standard (Dynamic RNP) is outlined. Sample data is presented from an ongoing high-fidelity batch simulation series that is characterizing the performance of an advanced 4D-ASAS application. Data of this type will contribute to the evaluation and validation of the proposed performance basis.

  4. Entwicklung und Formulierung der Unternehmensstrategie

    NASA Astrophysics Data System (ADS)

    Crespo, Isabel; Bergmann, Lars; Lacker, Thomas

    Ursprünglich stammt der Begriff "Strategie“ aus dem Altgriechischen: "strategos“ bedeutete "Heer“, "Heeresmacht“ und damit auch "konzentrierte Kraft“; das Wort "agein“ bedeutete "tun, machen, treiben“. Ein Stratege war also eine Person, die ein Heer führte und damit Kraft, Macht und Stärke konzentrierte und einsetzen konnte. Strategie bezeichnete dementsprechend die Maßnahmen, die in dieser Funktion entwickelt wurden. Daher ist es leicht verständlich, dass der Begriff Strategie bis in die Mitte des letzten Jahrhunderts in erster Linie militärisch verstanden wurde. Anschließend wurde der Begriff in weiteren Bereichen, wie beispielsweise der Unternehmensführung, verwendet. Im betriebswirtschaftlichen Sinne bedeutet der Begriff Strategie die langfristig geplante Verhaltensweise eines Unternehmens zur Erreichung seiner Ziele.

  5. 14 CFR 400.1 - Basis.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Basis. 400.1 Section 400.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL BASIS AND SCOPE § 400.1 Basis. The basis for the regulations in this chapter is the...

  6. 14 CFR 400.1 - Basis.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Basis. 400.1 Section 400.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL BASIS AND SCOPE § 400.1 Basis. The basis for the regulations in this chapter is the...

  7. 14 CFR 400.1 - Basis.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Basis. 400.1 Section 400.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL BASIS AND SCOPE § 400.1 Basis. The basis for the regulations in this chapter is the...

  8. 14 CFR 400.1 - Basis.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Basis. 400.1 Section 400.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL BASIS AND SCOPE § 400.1 Basis. The basis for the regulations in this chapter is the...

  9. 14 CFR 400.1 - Basis.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Basis. 400.1 Section 400.1 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION GENERAL BASIS AND SCOPE § 400.1 Basis. The basis for the regulations in this chapter is the...

  10. 10 CFR 830.202 - Safety basis.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Safety basis. 830.202 Section 830.202 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.202 Safety basis. (a) The contractor responsible for a hazard category 1, 2, or 3 DOE nuclear facility must establish and maintain the safety basis...

  11. 10 CFR 830.202 - Safety basis.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Safety basis. 830.202 Section 830.202 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.202 Safety basis. (a) The contractor responsible for a hazard category 1, 2, or 3 DOE nuclear facility must establish and maintain the safety basis...

  12. 10 CFR 830.202 - Safety basis.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Safety basis. 830.202 Section 830.202 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.202 Safety basis. (a) The contractor responsible for a hazard category 1, 2, or 3 DOE nuclear facility must establish and maintain the safety basis...

  13. 10 CFR 830.202 - Safety basis.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Safety basis. 830.202 Section 830.202 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.202 Safety basis. (a) The contractor... in the safety basis any changes, conditions, or hazard controls directed by DOE....

  14. Genetic basis of cognitive disability

    PubMed Central

    Flint, Jonathan

    2001-01-01

    The importance of genetic influences on cognitive disability has been recognized for a long time, but molecular analysis has only recently begun to yield insights into the pathogenesis of this common and disabling condition. The availability of genome sequences has enabled the characterization of the chromosomal deletions and trisomies that result in cognitive disability, and mutations in rare single-gene conditions are being discovered. The molecular pathology of cognitive disability is turning out to be as heterogeneous as the condition itself, with unexpected complexities even in apparently simple gene-deletion syndromes. One remarkable finding from studies on X-linked mental retardation is that mutations in different small guanosine triphosphate (GTP)-binding proteins result in cognitive disability without other somatic features. Advances are also being made in cognitive disability with polygenic origins, such as dyslexia and autism. However, the genetic basis of mild intellectual disability has yet to be satisfactorily explained. PMID:22034445

  15. [Natural science basis of individuality].

    PubMed

    Simonov, P V

    1981-01-01

    Results of experiments on animals with ablation of different parts of the brain and analysis of published data suggest that the neurophysiological basis of temperaments, according to Hippocrates, of nervous system types, according to Pavlov, and of extra-introversion consists in individual peculiarities of interaction of four structures: the frontal neocortex, the hippocampus, the amygdala and the hypothalamus. Pathological disturbance of this interaction produces the basic varieties of neuroses: hysteria, neurasthenia, psychasthenia and obsessive states. The significance is discussed of individual features of sets and hierarchy of basal human needs: material-biological, social, ideal (with their variants: retention and development, "for oneself" and "for others") needs of overcoming (will) and of "fitness" - for the formation of individuality.

  16. Internal dosimetry technical basis manual

    SciTech Connect

    Not Available

    1990-12-20

    The internal dosimetry program at the Savannah River Site (SRS) consists of radiation protection programs and activities used to detect and evaluate intakes of radioactive material by radiation workers. Examples of such programs are: air monitoring; surface contamination monitoring; personal contamination surveys; radiobioassay; and dose assessment. The objectives of the internal dosimetry program are to demonstrate that the workplace is under control and that workers are not being exposed to radioactive material, and to detect and assess inadvertent intakes in the workplace. The Savannah River Site Internal Dosimetry Technical Basis Manual (TBM) is intended to provide a technical and philosophical discussion of the radiobioassay and dose assessment aspects of the internal dosimetry program. Detailed information on air, surface, and personal contamination surveillance programs is not given in this manual except for how these programs interface with routine and special bioassay programs.

  17. Molecular basis of oral cancer.

    PubMed

    Saiz-Rodriguez, A

    2001-01-01

    In this article we try to analyze the current knowledge on the molecular basis of the carcinogenesis and their application in the oral cancer. Molecular Biology, has contributed in a great manner, with the etiology of cancer, because it has allowed to explain the genetic mechanisms by which a cell becomes and acquires a malignant phenotype. In the chromosome of a cell exist genes (protooncogenes), that promote phenomes of growth, maturation and normal cellular proliferation. Sometimes, these protooncogenes can suffer mutations that cause an alteration in their normal function. These genes are called oncogenes. We described the most important protein products of oncogenes, as well as, the tumor-suppressor genes, with special attention in the p53 gene.

  18. The Chemical Basis of Pharmacology

    PubMed Central

    2010-01-01

    Molecular biology now dominates pharmacology so thoroughly that it is difficult to recall that only a generation ago the field was very different. To understand drug action today, we characterize the targets through which they act and new drug leads are discovered on the basis of target structure and function. Until the mid-1980s the information often flowed in reverse: investigators began with organic molecules and sought targets, relating receptors not by sequence or structure but by their ligands. Recently, investigators have returned to this chemical view of biology, bringing to it systematic and quantitative methods of relating targets by their ligands. This has allowed the discovery of new targets for established drugs, suggested the bases for their side effects, and predicted the molecular targets underlying phenotypic screens. The bases for these new methods, some of their successes and liabilities, and new opportunities for their use are described. PMID:21058655

  19. BASIS Set Exchange (BSE): Chemistry Basis Sets from the William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) Basis Set Library

    DOE Data Explorer

    Feller, D; Schuchardt, Karen L.; Didier, Brett T.; Elsethagen, Todd; Sun, Lisong; Gurumoorthi, Vidhya; Chase, Jared; Li, Jun

    The Basis Set Exchange (BSE) provides a web-based user interface for downloading and uploading Gaussian-type (GTO) basis sets, including effective core potentials (ECPs), from the EMSL Basis Set Library. It provides an improved user interface and capabilities over its predecessor, the EMSL Basis Set Order Form, for exploring the contents of the EMSL Basis Set Library. The popular Basis Set Order Form and underlying Basis Set Library were originally developed by Dr. David Feller and have been available from the EMSL webpages since 1994. BSE not only allows downloading of the more than 500 Basis sets in various formats; it allows users to annotate existing sets and to upload new sets. (Specialized Interface)

  20. Structural basis of spectrin elasticity

    SciTech Connect

    Shen, B.W.; Stevens, F.J.; Luthi, U.; Goldin, S.B.

    1991-10-17

    A new model of human erythrocyte {alpha}-spectrin is proposed. The secondary structure of human erythrocyte {alpha}-spectrin and its folding into a condensed structure that can convert reversibly in situ, into an elongated configuration is predicted from its deduced protein sequence. Results from conformational and amphipathicity analyses suggest that {alpha}-spectrin consists mainly of short amphipathicity helices interconnected by flexible turns and/or coils. The distribution of charges and amphipathicity of the helices can facilitate their folding into stable domains of 4 and 3 helices surrounding a hydrophobic core. The association between adjacent four- and three-helix domains further organize them into recurring seven-helix motifs that might constitute the basic structural units of the extended {alpha}-spectrin. The elongated spectrin molecule packs, in a sinusoidal fashion, through interactions between neighboring motifs into a compact structure. We suggest that the reversible extension and contraction of this sigmoidally packed structure is the molecular basis of the mechanism by which spectrin contributes to the elasticity of the red cell membrane.

  1. Advanced Fuel Cycle Cost Basis

    SciTech Connect

    D. E. Shropshire; K. A. Williams; W. B. Boore; J. D. Smith; B. W. Dixon; M. Dunzik-Gougar; R. D. Adams; D. Gombert; E. Schneider

    2009-12-01

    This report, commissioned by the U.S. Department of Energy (DOE), provides a comprehensive set of cost data supporting a cost analysis for the relative economic comparison of options for use in the Advanced Fuel Cycle Initiative (AFCI) Program. The report describes the AFCI cost basis development process, reference information on AFCI cost modules, a procedure for estimating fuel cycle costs, economic evaluation guidelines, and a discussion on the integration of cost data into economic computer models. This report contains reference cost data for 25 cost modules—23 fuel cycle cost modules and 2 reactor modules. The cost modules were developed in the areas of natural uranium mining and milling, conversion, enrichment, depleted uranium disposition, fuel fabrication, interim spent fuel storage, reprocessing, waste conditioning, spent nuclear fuel (SNF) packaging, long-term monitored retrievable storage, near surface disposal of low-level waste (LLW), geologic repository and other disposal concepts, and transportation processes for nuclear fuel, LLW, SNF, transuranic, and high-level waste.

  2. Structural basis for selectin mechanochemistry.

    PubMed

    Springer, Timothy A

    2009-01-06

    Selectins are adhesion molecules that resist large tensile forces applied by hydrodynamic forces to leukocytes binding to vessel walls. In crystals, the liganded (high-affinity) and unliganded (low-affinity) conformations differ in orientation between their tandem lectin and EGF domains. I examine how tensile force exerted on a selectin-ligand complex in vivo could favor the more extended, high-affinity conformation. Allostery is transmitted from the EGF-lectin domain interface to the ligand-binding interface on the lectin domain, 30 A away. Trp-1 of the lectin domain and the long axis of the EGF domain form an L-shaped prybar that is welded together by hydrogen bonds to the Trp-1 alpha-amino group. Pivoting of the prybar induced by force demolishes an interface between the Trp-1 side chain and the lectin domain at a switch1 region. These changes are transmitted by rigid body movement of the switch2 region to rearrangements in the switch3 region at the ligand binding site. Another switch region corresponds to a single residue in the EGF domain with large effects on ligand binding and rolling adhesion. Allostery in selectins, and the alignment of tensile force on a selectin-ligand complex with the transition pathway for conformational change, explain much of the structural basis for selectin mechanochemistry.

  3. Basis Document for Sludge Stabilization

    SciTech Connect

    RISENMAY, H.R.

    2001-06-18

    DOE-RL recently issued Safety Evaluation Report (SER) amendments to the PFP Final Safety Analysis Report, HNF-SD-CP-SAR-021 Rev. 2. The Justification for Continued Operations for 2736-ZB and plutonium oxides in BTCs Safety Basis change (letter DOE-RL ABD-074) was approved by one of the SERs. Also approved by SER was the revised accident analysis for Magnesium Hydroxide Precipitation Process (MHPP) gloveboxes HC-230C-3 and HC-230C-5 containing increased glovebox inventories and corresponding increases in seismic release consequence. Numerous implementing documents require revision and issuance to implement the SER approvals. The SER authorizing plutonium oxides into BTCs specifically limited the SER authorization scope to ''pure or clean oxides, i.e., 85 wt% or grater Pu, in this feed change'' (SER Section 3.0 Base Information paragraph 4 [page 11]). Comprehensive USQ Evaluation PFP-2001-12 addressed the packaging of Pu alloy metals into BTCs, and the packaging of Pu alloy oxides (powders) into food pack cans and determined that the activities did not represent an USQ. The same information used to make the PFP-2001-12 negative USQ determination is applicable to packaging Pu alloy powders (DOES NOT INCLUDE STABILIZED MHPP MATERIALS OR OXIDES OF MOLYBDATES) into BTCs. Information from USQ Evaluation PFP-2001-12 is included in this USQ Evaluation for packaging of relatively pure Pu oxides and Pu alloy oxides into BTCs.

  4. Advanced Fuel Cycle Cost Basis

    SciTech Connect

    D. E. Shropshire; K. A. Williams; W. B. Boore; J. D. Smith; B. W. Dixon; M. Dunzik-Gougar; R. D. Adams; D. Gombert

    2007-04-01

    This report, commissioned by the U.S. Department of Energy (DOE), provides a comprehensive set of cost data supporting a cost analysis for the relative economic comparison of options for use in the Advanced Fuel Cycle Initiative (AFCI) Program. The report describes the AFCI cost basis development process, reference information on AFCI cost modules, a procedure for estimating fuel cycle costs, economic evaluation guidelines, and a discussion on the integration of cost data into economic computer models. This report contains reference cost data for 26 cost modules—24 fuel cycle cost modules and 2 reactor modules. The cost modules were developed in the areas of natural uranium mining and milling, conversion, enrichment, depleted uranium disposition, fuel fabrication, interim spent fuel storage, reprocessing, waste conditioning, spent nuclear fuel (SNF) packaging, long-term monitored retrievable storage, near surface disposal of low-level waste (LLW), geologic repository and other disposal concepts, and transportation processes for nuclear fuel, LLW, SNF, and high-level waste.

  5. Advanced Fuel Cycle Cost Basis

    SciTech Connect

    D. E. Shropshire; K. A. Williams; W. B. Boore; J. D. Smith; B. W. Dixon; M. Dunzik-Gougar; R. D. Adams; D. Gombert; E. Schneider

    2008-03-01

    This report, commissioned by the U.S. Department of Energy (DOE), provides a comprehensive set of cost data supporting a cost analysis for the relative economic comparison of options for use in the Advanced Fuel Cycle Initiative (AFCI) Program. The report describes the AFCI cost basis development process, reference information on AFCI cost modules, a procedure for estimating fuel cycle costs, economic evaluation guidelines, and a discussion on the integration of cost data into economic computer models. This report contains reference cost data for 25 cost modules—23 fuel cycle cost modules and 2 reactor modules. The cost modules were developed in the areas of natural uranium mining and milling, conversion, enrichment, depleted uranium disposition, fuel fabrication, interim spent fuel storage, reprocessing, waste conditioning, spent nuclear fuel (SNF) packaging, long-term monitored retrievable storage, near surface disposal of low-level waste (LLW), geologic repository and other disposal concepts, and transportation processes for nuclear fuel, LLW, SNF, transuranic, and high-level waste.

  6. Cellular basis for QT dispersion.

    PubMed

    Antzelevitch, C; Shimizu, W; Yan, G X; Sicouri, S

    1998-01-01

    The cellular basis for the dispersion of the QT interval recorded at the body surface is incompletely understood. Contributing to QT dispersion are heterogeneities of repolarization time in the three-dimensional structure of the ventricular myocardium, which are secondary to regional differences in action potential duration (APD) and activation time. While differences in APD occur along the apicobasal and anteroposterior axes in both epicardium and endocardium of many species, transitions are usually gradual. Recent studies have also demonstrated important APD gradients along the transmural axis. Because transmural heterogeneities in repolarization time are more abrupt than those recorded along the surfaces of the heart, they may represent a more onerous substrate for the development of arrhythmias, and their quantitation may provide a valuable tool for evaluation of arrhythmia risk. Our data, derived from the arterially perfused canine left ventricular wedge preparation, suggest that transmural gradients of voltage during repolarization contribute importantly to the inscription of the T wave. The start of the T wave is caused by a more rapid decline of the plateau, or phase 2 of the epicardial action potential, creating a voltage gradient across the wall. The gradient increases as the epicardial action potential continues to repolarize, reaching a maximum with full repolarization of epicardium; this juncture marks the peak of the T wave. The next region to repolarize is endocardium, giving rise to the initial descending limb of the upright T wave. The last region to repolarize is the M region, contributing to the final segment of the T wave. Full repolarization of the M region marks the end of the T wave. The time interval between the peak and the end of the T wave therefore represents the transmural dispersion of repolarization. Conditions known to augment QTc dispersion, including acquired long QT syndrome (class IA or III antiarrhythmics) lead to augmentation

  7. Molecular basis for erythrocyte shape

    NASA Astrophysics Data System (ADS)

    Elgsaeter, A.; Mikkelsen, A.

    1991-05-01

    The isolated plasma membrane of the human erythrocytes displays the same shape and shape transformations as the intact cells. It is therefore generally believed that the plasma membrane plays a dominant role in determining erythrocyte shape. The plasma membrane consists of a fluid lipid bilayer to the surface of which is attached a protein skeleton. The two halves of the lipid bilayer and the protein network (gel) are tighly coupled, but at the same time elastically deformable and can slide relative to one another in the plane of the cell membrane. The equilibrium shape of such a structure is determined by the combined mechano-chemical properties of the individual layers and equals the cell shape that for the given cell volume corresponds to the lowest total elastic free energy. The elastic free energy of the lipid bilayer is mainly associated with bending and change in surface area for each of the two lipid monolayer. For the protein membrane skeleton the elastic free energy mainly equals the sum of the local contributions due to shear deformation and surface change. When the mechano-chemical properties of each of the layers are known, calculation of the equilibrium shape is in principle just an exercise in standard continuum mechanics. The elastic properties of pure lipid monolayers have long been qualitatively fairly well known. The changes in lipid bilayer elastic properties resulting from the presence of integral membrane proteins have just recently become better understood. The detailed molecular basis for the elastic properties of the protein membrane skeleton remains unresolved despite many attempts to elucidate the problem. It is widely agreed that the elastic properties are largely accounted for by the highly elongated spectrin molecules, but whether the membrane skelton elasticity is mainly of entropic or entalphic origin is still unsettled.

  8. Functional Brain Basis of Hypnotizability

    PubMed Central

    Hoeft, Fumiko; Gabrieli, John D.E.; Whitfield-Gabrieli, Susan; Haas, Brian W.; Bammer, Roland; Menon, Vinod; Spiegel, David

    2015-01-01

    Context Focused hypnotic concentration is a model for brain control over sensation and behavior. Pain and anxiety can be effectively alleviated by hypnotic suggestion, which modulates activity in brain regions associated with focused attention, but the specific neural network underlying this phenomenon is not known. Objective The main goal of the study was to investigate the brain basis of hypnotizability. Design Cross sectional, in-vivo neuroimaging study. Setting Academic medical center at Stanford University School of Medicine. Patients 12 adults with high and 12 adults with low hypnotizability. Main Outcome Measures (1) functional MRI (fMRI) to measure functional connectivity networks at rest including default-mode, salience and executive-control networks, (2) structural T1 MRI to measure regional grey and white matter volumes, and (3) diffusion tensor imaging (DTI) to measure white matter microstructural integrity. Results High-compared to low-hypnotizable individuals showed greater functional connectivity between left dorsolateral prefrontal cortex (DLPFC), an executive-control region of the brain, and the salience network composed of the dorsal anterior cingulate cortex (dACC), anterior insula, amygdala, and ventral striatum, involved in detecting, integrating, and filtering relevant somatic, autonomic, and emotional information, using independent component analysis (ICA). Seed based analysis confirmed elevated functional coupling between the dACC and the DLPFC in high, compared to low, hypnotizables. These functional differences were not due to variation in brain structure in these regions, including regional grey and white matter volumes and white matter microstructure. Conclusions Our results provide novel evidence that altered functional connectivity in DLPFC and dACC may underlie hypnotizability. Future studies focusing on how these functional networks change and interact during hypnosis are warranted. PMID:23026956

  9. Positive basis for surface skein algebras

    PubMed Central

    Thurston, Dylan Paul

    2014-01-01

    We show that the twisted SL2 skein algebra of a surface has a natural basis (the bracelets basis) that is positive, in the sense that the structure constants for multiplication are positive integers. PMID:24982193

  10. 10 CFR 830.202 - Safety basis.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Safety basis. 830.202 Section 830.202 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.202 Safety basis. (a) The contractor responsible for a hazard category 1, 2, or 3 DOE nuclear facility must establish and maintain the safety...

  11. System requirements and design description for the document basis database interface (DocBasis)

    SciTech Connect

    Lehman, W.J.

    1997-09-30

    This document describes system requirements and the design description for the Document Basis Database Interface (DocBasis). The DocBasis application is used to manage procedures used within the tank farms. The application maintains information in a small database to track the document basis for a procedure, as well as the current version/modification level and the basis for the procedure. The basis for each procedure is substantiated by Administrative, Technical, Procedural, and Regulatory requirements. The DocBasis user interface was developed by Science Applications International Corporation (SAIC).

  12. Authorization basis for the 209-E Building

    SciTech Connect

    TIFFANY, M.S.

    1999-02-23

    This Authorization Basis document is one of three documents that constitute the Authorization Basis for the 209-E Building. Per the U.S. Department of Energy, Richland Operations Office (RL) letter 98-WSD-074, this document, the 209-E Building Preliminary Hazards Analysis (WHC-SD-WM-TI-789), and the 209-E Building Safety Evaluation Report (97-WSD-074) constitute the Authorization Basis for the 209-E Building. This Authorization Basis and the associated controls and safety programs will remain in place until safety documentation addressing deactivation of the 209-E Building is developed by the contractor and approved by RL.

  13. Estimating the CCSD basis-set limit energy from small basis sets: basis-set extrapolations vs additivity schemes

    SciTech Connect

    Spackman, Peter R.; Karton, Amir

    2015-05-15

    Coupled cluster calculations with all single and double excitations (CCSD) converge exceedingly slowly with the size of the one-particle basis set. We assess the performance of a number of approaches for obtaining CCSD correlation energies close to the complete basis-set limit in conjunction with relatively small DZ and TZ basis sets. These include global and system-dependent extrapolations based on the A + B/L{sup α} two-point extrapolation formula, and the well-known additivity approach that uses an MP2-based basis-set-correction term. We show that the basis set convergence rate can change dramatically between different systems(e.g.it is slower for molecules with polar bonds and/or second-row elements). The system-dependent basis-set extrapolation scheme, in which unique basis-set extrapolation exponents for each system are obtained from lower-cost MP2 calculations, significantly accelerates the basis-set convergence relative to the global extrapolations. Nevertheless, we find that the simple MP2-based basis-set additivity scheme outperforms the extrapolation approaches. For example, the following root-mean-squared deviations are obtained for the 140 basis-set limit CCSD atomization energies in the W4-11 database: 9.1 (global extrapolation), 3.7 (system-dependent extrapolation), and 2.4 (additivity scheme) kJ mol{sup –1}. The CCSD energy in these approximations is obtained from basis sets of up to TZ quality and the latter two approaches require additional MP2 calculations with basis sets of up to QZ quality. We also assess the performance of the basis-set extrapolations and additivity schemes for a set of 20 basis-set limit CCSD atomization energies of larger molecules including amino acids, DNA/RNA bases, aromatic compounds, and platonic hydrocarbon cages. We obtain the following RMSDs for the above methods: 10.2 (global extrapolation), 5.7 (system-dependent extrapolation), and 2.9 (additivity scheme) kJ mol{sup –1}.

  14. 29 CFR 552.5 - Casual basis.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 3 2011-07-01 2011-07-01 false Casual basis. 552.5 Section 552.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS APPLICATION OF THE FAIR LABOR STANDARDS ACT TO DOMESTIC SERVICE General Regulations § 552.5 Casual basis. As used...

  15. 29 CFR 552.5 - Casual basis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Casual basis. 552.5 Section 552.5 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS APPLICATION OF THE FAIR LABOR STANDARDS ACT TO DOMESTIC SERVICE General Regulations § 552.5 Casual basis. As used...

  16. 42 CFR 418.1 - Statutory basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Statutory basis. 418.1 Section 418.1 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM HOSPICE CARE General Provision and Definitions § 418.1 Statutory basis. This part...

  17. 20 CFR 900.1 - Basis.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Basis. 900.1 Section 900.1 Employees' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES STATEMENT OF ORGANIZATION § 900.1 Basis. This statement is issued by the Joint Board for the Enrollment of Actuaries (the Joint Board) pursuant to...

  18. 47 CFR 10.1 - Basis.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Basis. 10.1 Section 10.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL WIRELESS EMERGENCY ALERTS General Information § 10.1 Basis. The... Network Act, Title VI of the Security and Accountability for Every Port Act of 2006, Public Law...

  19. 47 CFR 10.1 - Basis.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Basis. 10.1 Section 10.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL WIRELESS EMERGENCY ALERTS General Information § 10.1 Basis. The... Network Act, Title VI of the Security and Accountability for Every Port Act of 2006, Public Law...

  20. 42 CFR 488.800 - Statutory basis.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Statutory basis. 488.800 Section 488.800 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... Health Agencies With Deficiencies § 488.800 Statutory basis. Section 1891(e) through (f) of the...

  1. 42 CFR 488.800 - Statutory basis.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Statutory basis. 488.800 Section 488.800 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... Health Agencies With Deficiencies § 488.800 Statutory basis. Section 1891(e) through (f) of the...

  2. 41 CFR 105-70.001 - Basis.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false Basis. 105-70.001...-IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 105-70.001 Basis. This part implements the Program Fraud Civil Remedies Act of 1986, Pub. L. No. 99-509, 6101-6104, 100 Stat. 1874 (October 21,...

  3. 42 CFR 460.2 - Basis.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 4 2011-10-01 2011-10-01 false Basis. 460.2 Section 460.2 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Basis,...

  4. 42 CFR 460.2 - Basis.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Basis. 460.2 Section 460.2 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Basis,...

  5. 42 CFR 460.2 - Basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Basis. 460.2 Section 460.2 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Basis,...

  6. 42 CFR 460.2 - Basis.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Basis. 460.2 Section 460.2 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Basis,...

  7. 42 CFR 460.2 - Basis.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Basis. 460.2 Section 460.2 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) PROGRAMS OF ALL-INCLUSIVE CARE FOR THE ELDERLY (PACE) Basis,...

  8. 22 CFR 9.1 - Basis.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Basis. 9.1 Section 9.1 Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.1 Basis. These regulations, taken together with the Information Security Oversight Office Directive No. 1 dated September 22, 2003, and Volume 5 of the Department's Foreign Affairs Manual,...

  9. 22 CFR 9.1 - Basis.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Basis. 9.1 Section 9.1 Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.1 Basis. These regulations, taken together with the Information Security Oversight Office Directive No. 1 dated September 22, 2003, and Volume 5 of the Department's Foreign Affairs Manual,...

  10. 22 CFR 9.1 - Basis.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Basis. 9.1 Section 9.1 Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.1 Basis. These regulations, taken together with the Information Security Oversight Office Directive No. 1 dated September 22, 2003, and Volume 5 of the Department's Foreign Affairs Manual,...

  11. 22 CFR 9.1 - Basis.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Basis. 9.1 Section 9.1 Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.1 Basis. These regulations, taken together with the Information Security Oversight Office Directive No. 1 dated September 22, 2003, and Volume 5 of the Department's Foreign Affairs Manual,...

  12. Stimulus Overselectivity: Empirical Basis and Diagnostic Methods

    ERIC Educational Resources Information Center

    Cipani, Ennio

    2012-01-01

    This paper presents the empirical basis for the phenomena known as stimulus overselectivity. Stimulus overselectivity involves responding on the basis of a restricted range of elements or features that are discriminative for reinforcement. The manner in which such a response pattern impedes the skill acquisition in children is identified. A…

  13. 42 CFR 440.300 - Basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Basis. 440.300 Section 440.300 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL....300 Basis. This subpart implements section 1937 of the Act, which authorizes States to provide...

  14. 42 CFR 433.300 - Basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Basis. 433.300 Section 433.300 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... Providers § 433.300 Basis. This subpart implements— (a) Section 1903(d)(2)(A) of the Act, which directs...

  15. 42 CFR 433.300 - Basis.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Basis. 433.300 Section 433.300 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... Providers § 433.300 Basis. This subpart implements— (a) Section 1903(d)(2)(A) of the Act, which directs...

  16. Advanced Test Reactor Safety Basis Upgrade Lessons Learned Relative to Design Basis Verification and Safety Basis Management

    SciTech Connect

    G. L. Sharp; R. T. McCracken

    2004-05-01

    The Advanced Test Reactor (ATR) is a pressurized light-water reactor with a design thermal power of 250 MW. The principal function of the ATR is to provide a high neutron flux for testing reactor fuels and other materials. The reactor also provides other irradiation services such as radioisotope production. The ATR and its support facilities are located at the Test Reactor Area of the Idaho National Engineering and Environmental Laboratory (INEEL). An audit conducted by the Department of Energy's Office of Independent Oversight and Performance Assurance (DOE OA) raised concerns that design conditions at the ATR were not adequately analyzed in the safety analysis and that legacy design basis management practices had the potential to further impact safe operation of the facility.1 The concerns identified by the audit team, and issues raised during additional reviews performed by ATR safety analysts, were evaluated through the unreviewed safety question process resulting in shutdown of the ATR for more than three months while these concerns were resolved. Past management of the ATR safety basis, relative to facility design basis management and change control, led to concerns that discrepancies in the safety basis may have developed. Although not required by DOE orders or regulations, not performing design basis verification in conjunction with development of the 10 CFR 830 Subpart B upgraded safety basis allowed these potential weaknesses to be carried forward. Configuration management and a clear definition of the existing facility design basis have a direct relation to developing and maintaining a high quality safety basis which properly identifies and mitigates all hazards and postulated accident conditions. These relations and the impact of past safety basis management practices have been reviewed in order to identify lessons learned from the safety basis upgrade process and appropriate actions to resolve possible concerns with respect to the current ATR safety

  17. Maximal coherence in a generic basis

    NASA Astrophysics Data System (ADS)

    Yao, Yao; Dong, G. H.; Ge, Li; Li, Mo; Sun, C. P.

    2016-12-01

    Since quantum coherence is an undoubted characteristic trait of quantum physics, the quantification and application of quantum coherence has been one of the long-standing central topics in quantum information science. Within the framework of a resource theory of quantum coherence proposed recently, a fiducial basis should be preselected for characterizing the quantum coherence in specific circumstances, namely, the quantum coherence is a basis-dependent quantity. Therefore, a natural question is raised: what are the maximum and minimum coherences contained in a certain quantum state with respect to a generic basis? While the minimum case is trivial, it is not so intuitive to verify in which basis the quantum coherence is maximal. Based on the coherence measure of relative entropy, we indicate the particular basis in which the quantum coherence is maximal for a given state, where the Fourier matrix (or more generally, complex Hadamard matrices) plays a critical role in determining the basis. Intriguingly, though we can prove that the basis associated with the Fourier matrix is a stationary point for optimizing the l1 norm of coherence, numerical simulation shows that it is not a global optimal choice.

  18. 21 CFR 120.9 - Legal basis.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... CONSUMPTION HAZARD ANALYSIS AND CRITICAL CONTROL POINT (HACCP) SYSTEMS General Provisions § 120.9 Legal basis. Failure of a processor to have and to implement a Hazard Analysis and Critical Control Point...

  19. Wavelets, Fractals, and Radial Basis Functions

    DTIC Science & Technology

    2007-11-02

    of Signal Processing. San Diego, CA: Aca- demic, 1998. [13] G. Strang and T. Q. Nguyen, Wavelets and Filter Banks . Cambridge, MA: Wellesley-Cambridge...localization, multiresolution, radial basis functions, re- finement filter , scaling functions, self-similarity, splines, tempered distributions, two-scale...one linear constraint per basis function, and the corresponding linear system of equations is invertible under relatively mild conditions [11]. The

  20. Nanoplasmonics simulations at the basis set limit through completeness-optimized, local numerical basis sets

    SciTech Connect

    Rossi, Tuomas P. Sakko, Arto; Puska, Martti J.; Lehtola, Susi; Nieminen, Risto M.

    2015-03-07

    We present an approach for generating local numerical basis sets of improving accuracy for first-principles nanoplasmonics simulations within time-dependent density functional theory. The method is demonstrated for copper, silver, and gold nanoparticles that are of experimental interest but computationally demanding due to the semi-core d-electrons that affect their plasmonic response. The basis sets are constructed by augmenting numerical atomic orbital basis sets by truncated Gaussian-type orbitals generated by the completeness-optimization scheme, which is applied to the photoabsorption spectra of homoatomic metal atom dimers. We obtain basis sets of improving accuracy up to the complete basis set limit and demonstrate that the performance of the basis sets transfers to simulations of larger nanoparticles and nanoalloys as well as to calculations with various exchange-correlation functionals. This work promotes the use of the local basis set approach of controllable accuracy in first-principles nanoplasmonics simulations and beyond.

  1. Test Review: Schneller, J. (2005). "Psychosocial Evaluation and Threat Risk Assessment (PETRA)." Lutz, FL--Psychological Assessment Resources

    ERIC Educational Resources Information Center

    Sullivan, Jeremy R.; Holcomb, Michelle R.

    2010-01-01

    This article presents a review of the "Psychosocial Evaluation and Threat Risk Assessment" (PETRA), a 60-item self-report instrument "designed to address the psychosocial characteristics most commonly associated with acts of school violence" among middle school and high school students ages 11 to 18 years. The PETRA was…

  2. Boiling water reactor licensing basis transient

    SciTech Connect

    Cheng, H. S.; Lu, M. S.; Shier, W. G.; Diamond, D. J.; Levine, M. M.; Odar, F.

    1980-01-01

    An analysis is presented of the licensing basis transient for a boiling water reactor where a turbine trip occurs without steam bypass. The analysis was performed by means of the two-dimensional (R,Z) core dynamics code BNL-TWIGL in conjunction with the system transient code RELAP-3B. Two plant models were used and produced similar results for the analysis of the Peach Bottom turbine trip tests. The models differed in the representation of the steam separator. The analysis of the licensing basis transient produced somewhat different results. The results of sensitivity studies to help explain the differences are presented as well as an analysis of the licensing basis transient with recirculation pump trip. 2 refs., 17 figs., 1 tab.

  3. Heavy quarkonium in a holographic basis

    DOE PAGES

    Li, Yang; Maris, Pieter; Zhao, Xingbo; ...

    2016-05-04

    Here, we study the heavy quarkonium within the basis light-front quantization approach. We implement the one-gluon exchange interaction and a confining potential inspired by light-front holography. We adopt the holographic light-front wavefunction (LFWF) as our basis function and solve the non-perturbative dynamics by diagonalizing the Hamiltonian matrix. We obtain the mass spectrum for charmonium and bottomonium. With the obtained LFWFs, we also compute the decay constants and the charge form factors for selected eigenstates. The results are compared with the experimental measurements and with other established methods.

  4. The Q field, a variable quaternion basis

    SciTech Connect

    Efremov, A.P.

    1986-06-01

    The author introduces the concept of the Q field as a 2 x 2 matrix representation of the variable basis of vectors satisfying the rule of multiplication of quaternion imaginary numbers and as an element of the group of transformations of the basis preserving the invariance of this multiplication rule. The rule for projecting such matrices on a given direction is determined with the help of the characteristic functions of the matrices-vectors of the Q field. The differential structure of Q fields is studied and the theory developed is illustrated by an example of a model-topological classification of particles according to the magnitude of their spin.

  5. Reduced basis catalogs for gravitational wave templates.

    PubMed

    Field, Scott E; Galley, Chad R; Herrmann, Frank; Hesthaven, Jan S; Ochsner, Evan; Tiglio, Manuel

    2011-06-03

    We introduce a reduced basis approach as a new paradigm for modeling, representing and searching for gravitational waves. We construct waveform catalogs for nonspinning compact binary coalescences, and we find that for accuracies of 99% and 99.999% the method generates a factor of about 10-10(5) fewer templates than standard placement methods. The continuum of gravitational waves can be represented by a finite and comparatively compact basis. The method is robust under variations in the noise of detectors, implying that only a single catalog needs to be generated.

  6. Humanities--The Basis of University Education

    ERIC Educational Resources Information Center

    Stepanskaya, T. M.; Chernyaeva, I. V.; Naumova, V. I.

    2016-01-01

    The article analyzes the role of humanities in forming the worldview of modern person in the system of higher education. It emphasizes the idea that a graduate of the higher education institute, and especially the university, should not only be an expert (a professional), but above all, a person of culture. Humanities as the basis of university…

  7. 42 CFR 408.1 - Statutory basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Statutory basis. 408.1 Section 408.1 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM..., updated by a final rule published on January 5, 1987 (52 FR 260) set forth procedures for the exercise of...

  8. The neural basis of phantom limb pain.

    PubMed

    Flor, Herta; Diers, Martin; Andoh, Jamila

    2013-07-01

    A recent study suggests that brain changes in amputees may be pain-induced, questioning maladaptive plasticity as a neural basis of phantom pain. These findings add valuable information on cortical reorganization after amputation. We suggest further lines of research to clarify the mechanisms that underlie phantom pain.

  9. 42 CFR 436.2 - Basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Basis. 436.2 Section 436.2 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS ELIGIBILITY IN GUAM, PUERTO RICO, AND THE VIRGIN ISLANDS General Provisions and...

  10. The molecular basis of peanut allergy

    USDA-ARS?s Scientific Manuscript database

    Peanut allergens can trigger a potent and sometimes dangerous immune response in an increasing number of people. The molecular structures of these allergens form the basis for understanding this response. This review describes the currently known peanut allergen structures, and discusses how modif...

  11. On the optimization of Gaussian basis sets

    NASA Astrophysics Data System (ADS)

    Petersson, George A.; Zhong, Shijun; Montgomery, John A.; Frisch, Michael J.

    2003-01-01

    A new procedure for the optimization of the exponents, αj, of Gaussian basis functions, Ylm(ϑ,φ)rle-αjr2, is proposed and evaluated. The direct optimization of the exponents is hindered by the very strong coupling between these nonlinear variational parameters. However, expansion of the logarithms of the exponents in the orthonormal Legendre polynomials, Pk, of the index, j: ln αj=∑k=0kmaxAkPk((2j-2)/(Nprim-1)-1), yields a new set of well-conditioned parameters, Ak, and a complete sequence of well-conditioned exponent optimizations proceeding from the even-tempered basis set (kmax=1) to a fully optimized basis set (kmax=Nprim-1). The error relative to the exact numerical self-consistent field limit for a six-term expansion is consistently no more than 25% larger than the error for the completely optimized basis set. Thus, there is no need to optimize more than six well-conditioned variational parameters, even for the largest sets of Gaussian primitives.

  12. 42 CFR 483.100 - Basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Basis. 483.100 Section 483.100 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION REQUIREMENTS FOR STATES AND LONG TERM CARE FACILITIES Preadmission Screening...

  13. 42 CFR 483.200 - Statutory basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Statutory basis. 483.200 Section 483.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED..., Transfers, and Preadmission Screening and Annual Resident Review (PASARR) Determinations § 483.200...

  14. 42 CFR 483.200 - Statutory basis.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Statutory basis. 483.200 Section 483.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED..., Transfers, and Preadmission Screening and Annual Resident Review (PASARR) Determinations § 483.200...

  15. 42 CFR 483.100 - Basis.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Basis. 483.100 Section 483.100 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION REQUIREMENTS FOR STATES AND LONG TERM CARE FACILITIES Preadmission Screening...

  16. Developing a basis for moral thinking

    NASA Astrophysics Data System (ADS)

    Cowell, Barbara

    1995-01-01

    Writing from the standpoint of mother and teacher, the author asks from where we can start to find a basis of moral education. She rejects simply exchanging one basis for another. We need to agree upon principles which would enable us to judge what constitutes a right basis, rather than concentrating on the content of particular beliefs. She identifies four qualities that children need to be equipped with in order to act reasonably in situations where moral choice is required: recognition of the validity of others as equals; requisite emotional insight; factual knowledge; and a capacity to make, and act upon, principles formulated by using the above equipment. These "high-level" principles should take precedence over any creed — sacred or secular; to make this shift has become crucial on a national and international level. The general preconditions and practical possibilities for the implementation of moral education are then specified. Finally, the author questions why so few researchers and teachers are working on this basis — concluding that what hinders us is our tendency to see morality as derived from authority, instead of being "a form of thought in its own right'.

  17. 340 waste handling facility interim safety basis

    SciTech Connect

    VAIL, T.S.

    1999-04-01

    This document presents an interim safety basis for the 340 Waste Handling Facility classifying the 340 Facility as a Hazard Category 3 facility. The hazard analysis quantifies the operating safety envelop for this facility and demonstrates that the facility can be operated without a significant threat to onsite or offsite people.

  18. The Emotional and Moral Basis of Rationality

    ERIC Educational Resources Information Center

    Boostrom, Robert

    2013-01-01

    This chapter explores the basis of rationality, arguing that critical thinking tends to be taught in schools as a set of skills because of the failure to recognize that choosing to think critically depends on the prior development of stable sentiments or moral habits that nourish a rational self. Primary among these stable sentiments are the…

  19. 42 CFR 478.12 - Statutory basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Statutory basis. 478.12 Section 478.12 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS RECONSIDERATIONS AND APPEALS Utilization and Quality Control Quality...

  20. Salary basis of payment for overtime exemption.

    PubMed

    Gilliland, J C

    1994-07-01

    Often employers' problems in complying with the Fair Labor Standards Act salary basis of payment rules arise from their paid time off policies. Although it is possible to write policies that apply to both exempt and nonexempt employees, such policies are complex, and agencies may need to review their compliance with these rules.

  1. The Neuropsychological Basis of Childhood Psychopathology

    ERIC Educational Resources Information Center

    Davis, Andrew S.

    2006-01-01

    A clear link exists between neurological dysfunction and psychopathology in children, as evidenced by research on the sequelae of developmental childhood brain impairment, the neuropsychological investigation of children with psychiatric disorders, and neuroimaging research. Understanding the neuropsychological basis of a disorder helps teachers,…

  2. 42 CFR 406.1 - Statutory basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Statutory basis. 406.1 Section 406.1 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM..., 226A, 1818 and 1818A of the Social Security Act and section 103 of Public Law 89-97 establish...

  3. 45 CFR 160.201 - Statutory basis.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... this subpart implement section 1178 of the Act, section 262 of Public Law 104-191, section 264(c) of Public Law 104-191, and section 13421(a) of Public Law 111-5. ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Statutory basis. 160.201 Section 160.201...

  4. 45 CFR 164.102 - Statutory basis.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... specifications under part C of title XI of the Act, section 264 of Public Law 104-191, and section 13402 of Public Law 111-5. ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Statutory basis. 164.102 Section 164.102...

  5. 45 CFR 160.201 - Statutory basis.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... this subpart implement section 1178 of the Act, section 262 of Public Law 104-191, section 264(c) of Public Law 104-191, and section 13421(a) of Public Law 111-5. ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Statutory basis. 160.201 Section 160.201...

  6. 42 CFR 488.400 - Statutory basis.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Statutory basis. 488.400 Section 488.400 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... remedies are in addition to any other available under State or Federal law, and, except, for civil...

  7. 45 CFR 164.102 - Statutory basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... specifications under part C of title XI of the Act, section 264 of Public Law 104-191, and section 13402 of Public Law 111-5. ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Statutory basis. 164.102 Section 164.102...

  8. 42 CFR 406.1 - Statutory basis.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Statutory basis. 406.1 Section 406.1 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM..., 226A, 1818 and 1818A of the Social Security Act and section 103 of Public Law 89-97 establish...

  9. 41 CFR 105-70.001 - Basis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Basis. 105-70.001 Section 105-70.001 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services Administration...

  10. 14 CFR 1203.100 - Legal basis.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Legal basis. 1203.100 Section 1203.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Scope § 1203... that NASA has responsibility for safeguarding. (c) The National Aeronautics and Space Act. (1)...

  11. 14 CFR 1203.100 - Legal basis.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Legal basis. 1203.100 Section 1203.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Scope § 1203... that NASA has responsibility for safeguarding. (c) The National Aeronautics and Space Act. (1)...

  12. PRELIMINARY SELECTION OF MGR DESIGN BASIS EVENTS

    SciTech Connect

    J.A. Kappes

    1999-09-16

    The purpose of this analysis is to identify the preliminary design basis events (DBEs) for consideration in the design of the Monitored Geologic Repository (MGR). For external events and natural phenomena (e.g., earthquake), the objective is to identify those initiating events that the MGR will be designed to withstand. Design criteria will ensure that radiological release scenarios resulting from these initiating events are beyond design basis (i.e., have a scenario frequency less than once per million years). For internal (i.e., human-induced and random equipment failures) events, the objective is to identify credible event sequences that result in bounding radiological releases. These sequences will be used to establish the design basis criteria for MGR structures, systems, and components (SSCs) design basis criteria in order to prevent or mitigate radiological releases. The safety strategy presented in this analysis for preventing or mitigating DBEs is based on the preclosure safety strategy outlined in ''Strategy to Mitigate Preclosure Offsite Exposure'' (CRWMS M&O 1998f). DBE analysis is necessary to provide feedback and requirements to the design process, and also to demonstrate compliance with proposed 10 CFR 63 (Dyer 1999b) requirements. DBE analysis is also required to identify and classify the SSCs that are important to safety (ITS).

  13. The Biochemical Basis of Minimal Brain Dysfunction

    ERIC Educational Resources Information Center

    Shaywitz, Sally E.; And Others

    1978-01-01

    Available from: C. V. Mosby Company 11830 Westline Industrial Drive St. Louis, Missouri 63141 The research review examines evidence suggesting a biochemical basis for minimal brain dysfunction (MBD), which includes both a relationship between MBD and metabolic abnormalities and a significant genetic influence on the disorder in children. (IM)

  14. Conceptual Basis of Educational Service Resource Support

    ERIC Educational Resources Information Center

    Ledyankina, Olga V.; Akimova, Olga B.; Fomin, Evgenii P.

    2016-01-01

    Topicality of the issue researched is preconditioned by the need to describe the conceptual basis and significance of educational service resource support of at the current development stage of Russian vocational education, classification of its main components as well as significance of the need to transform resource support from the factor that…

  15. 14 CFR 1203.100 - Legal basis.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Legal basis. 1203.100 Section 1203.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Scope § 1203... that NASA has responsibility for safeguarding. (c) The National Aeronautics and Space Act. (1) Section...

  16. 14 CFR 1203.100 - Legal basis.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Legal basis. 1203.100 Section 1203.100 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Scope § 1203... that NASA has responsibility for safeguarding. (c) The National Aeronautics and Space Act. (1) Section...

  17. Analysis of radial basis function interpolation approach

    NASA Astrophysics Data System (ADS)

    Zou, You-Long; Hu, Fa-Long; Zhou, Can-Can; Li, Chao-Liu; Dunn, Keh-Jim

    2013-12-01

    The radial basis function (RBF) interpolation approach proposed by Freedman is used to solve inverse problems encountered in well-logging and other petrophysical issues. The approach is to predict petrophysical properties in the laboratory on the basis of physical rock datasets, which include the formation factor, viscosity, permeability, and molecular composition. However, this approach does not consider the effect of spatial distribution of the calibration data on the interpolation result. This study proposes a new RBF interpolation approach based on the Freedman's RBF interpolation approach, by which the unit basis functions are uniformly populated in the space domain. The inverse results of the two approaches are comparatively analyzed by using our datasets. We determine that although the interpolation effects of the two approaches are equivalent, the new approach is more flexible and beneficial for reducing the number of basis functions when the database is large, resulting in simplification of the interpolation function expression. However, the predicted results of the central data are not sufficiently satisfied when the data clusters are far apart.

  18. The Biological Basis of Learning and Individuality.

    ERIC Educational Resources Information Center

    Kandel, Eric R.; Hawkins, Robert D.

    1992-01-01

    Describes the biological basis of learning and individuality. Presents an overview of recent discoveries that suggest learning engages a simple set of rules that modify the strength of connection between neurons in the brain. The changes are cited as playing an important role in making each individual unique. (MCO)

  19. High Scores at BASIS Charter Schools

    ERIC Educational Resources Information Center

    Kronholz, June

    2014-01-01

    While U.S. schools struggled to reach even an average score on a key international exam for 15-year-olds in 2012, BASIS Tucson North, an economically modest, ethnically diverse charter school in Arizona, outperformed every country in the world, and left even Shanghai, China's academic gem in the dust. With the U.S. frantic about its place in the…

  20. 340 Waste handling facility interim safety basis

    SciTech Connect

    Stordeur, R.T.

    1996-10-04

    This document presents an interim safety basis for the 340 Waste Handling Facility classifying the 340 Facility as a Hazard Category 3 facility. The hazard analysis quantifies the operating safety envelop for this facility and demonstrates that the facility can be operated without a significant threat to onsite or offsite people.

  1. 42 CFR 411.200 - Basis.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM EXCLUSIONS FROM MEDICARE AND LIMITATIONS ON MEDICARE PAYMENT Special Rules: Disabled Beneficiaries Who Are Also Covered Under Large Group Health Plans § 411.200 Basis. (a) This subpart is based on...

  2. 42 CFR 411.200 - Basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM EXCLUSIONS FROM MEDICARE AND LIMITATIONS ON MEDICARE PAYMENT Special Rules: Disabled Beneficiaries Who Are Also Covered Under Large Group Health Plans § 411.200 Basis. (a) This subpart is based on...

  3. 29 CFR 541.605 - Fee basis.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...” within the meaning of these regulations if the employee is paid an agreed sum for a single job regardless... 29 Labor 3 2013-07-01 2013-07-01 false Fee basis. 541.605 Section 541.605 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING...

  4. 42 CFR 409.1 - Statutory basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HOSPITAL INSURANCE BENEFITS Hospital Insurance Benefits: General Provisions § 409.1 Statutory basis. This...) Sections 1812 and 1813 establish the scope of benefits of the hospital insurance program under Medicare... the critical access hospital program. (d) Section 1861 describes the services covered under Medicare...

  5. A reduced basis localized orthogonal decomposition

    NASA Astrophysics Data System (ADS)

    Abdulle, Assyr; Henning, Patrick

    2015-08-01

    In this work we combine the framework of the Reduced Basis method (RB) with the framework of the Localized Orthogonal Decomposition (LOD) in order to solve parametrized elliptic multiscale problems. The idea of the LOD is to split a high dimensional Finite Element space into a low dimensional space with comparably good approximation properties and a remainder space with negligible information. The low dimensional space is spanned by locally supported basis functions associated with the node of a coarse mesh obtained by solving decoupled local problems. However, for parameter dependent multiscale problems, the local basis has to be computed repeatedly for each choice of the parameter. To overcome this issue, we propose an RB approach to compute in an "offline" stage LOD for suitable representative parameters. The online solution of the multiscale problems can then be obtained in a coarse space (thanks to the LOD decomposition) and for an arbitrary value of the parameters (thanks to a suitable "interpolation" of the selected RB). The online RB-LOD has a basis with local support and leads to sparse systems. Applications of the strategy to both linear and nonlinear problems are given.

  6. The Emotional and Moral Basis of Rationality

    ERIC Educational Resources Information Center

    Boostrom, Robert

    2013-01-01

    This chapter explores the basis of rationality, arguing that critical thinking tends to be taught in schools as a set of skills because of the failure to recognize that choosing to think critically depends on the prior development of stable sentiments or moral habits that nourish a rational self. Primary among these stable sentiments are the…

  7. The Biological Basis of Learning and Individuality.

    ERIC Educational Resources Information Center

    Kandel, Eric R.; Hawkins, Robert D.

    1992-01-01

    Describes the biological basis of learning and individuality. Presents an overview of recent discoveries that suggest learning engages a simple set of rules that modify the strength of connection between neurons in the brain. The changes are cited as playing an important role in making each individual unique. (MCO)

  8. Alexia and the Neural Basis of Reading.

    ERIC Educational Resources Information Center

    Benson, D. Frank

    1984-01-01

    The historical background of alexia (loss or impairment of the ability to comprehend written or printed language based on damage to the brain) is reviewed, classification and symptomatology considered, theories on the involvement of right hemisphere reading are noted, and the neural basis of reading is postulated. (CL)

  9. A "Traditional" Linguistic Basis for Language Teaching

    ERIC Educational Resources Information Center

    Anthony, Edward M.

    1970-01-01

    Presents an essentially Bloomfieldian approach to language and language teaching; sees the concept of language as interplay between stimuli and reactions as the basis of a wholly creditable system of teaching, a tremendous number of textbooks, and a large number of language courses." (FB)

  10. 42 CFR 418.1 - Statutory basis.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PROGRAM (CONTINUED) HOSPICE CARE General Provision and Definitions § 418.1 Statutory basis. This part... services covered as hospice care and the conditions that a hospice program must meet in order to... for, inpatient hospice care. The following sections of the Act are also pertinent: (a) Sections...

  11. 42 CFR 418.1 - Statutory basis.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PROGRAM (CONTINUED) HOSPICE CARE General Provision and Definitions § 418.1 Statutory basis. This part... services covered as hospice care and the conditions that a hospice program must meet in order to... for, inpatient hospice care. The following sections of the Act are also pertinent: (a) Sections...

  12. 42 CFR 418.1 - Statutory basis.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PROGRAM (CONTINUED) HOSPICE CARE General Provision and Definitions § 418.1 Statutory basis. This part... services covered as hospice care and the conditions that a hospice program must meet in order to... for, inpatient hospice care. The following sections of the Act are also pertinent: (a) Sections...

  13. 42 CFR 418.1 - Statutory basis.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PROGRAM HOSPICE CARE General Provision and Definitions § 418.1 Statutory basis. This part implements... covered as hospice care and the conditions that a hospice program must meet in order to participate in the... hospice care. The following sections of the Act are also pertinent: (a) Sections 1812(a) (4) and (d)...

  14. THE METABOLIC BASIS OF ARSENIC TOXICITY

    EPA Science Inventory

    The Metabolic Basis of Arsenic Toxicity

    David J. Thomas, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC

    Methylati...

  15. 45 CFR 144.200 - Basis.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS REQUIREMENTS RELATING TO HEALTH INSURANCE COVERAGE Source: § 144.200 Basis. This subpart implements— (a) Section 1917(b)(1)(C) (iii)(VI) of the Social Security Act, (Act) which requires the issuer of a long-term care...

  16. 42 CFR 405.2400 - Basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Basis. 405.2400 Section 405.2400 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM FEDERAL HEALTH INSURANCE FOR THE AGED AND DISABLED Rural Health Clinic and Federally Qualified Health...

  17. 42 CFR 405.2400 - Basis.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Basis. 405.2400 Section 405.2400 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM FEDERAL HEALTH INSURANCE FOR THE AGED AND DISABLED Rural Health Clinic and Federally Qualified Health...

  18. 42 CFR 438.600 - Statutory basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS MANAGED CARE Certifications and Program Integrity § 438.600 Statutory basis... services are provided in a manner consistent with simplicity of administration and the best interests of...

  19. System Design and the Safety Basis

    SciTech Connect

    Ellingson, Darrel

    2008-05-06

    The objective of this paper is to present the Bechtel Jacobs Company, LLC (BJC) Lessons Learned for system design as it relates to safety basis documentation. BJC has had to reconcile incomplete or outdated system description information with current facility safety basis for a number of situations in recent months. This paper has relevance in multiple topical areas including documented safety analysis, decontamination & decommissioning (D&D), safety basis (SB) implementation, safety and design integration, potential inadequacy of the safety analysis (PISA), technical safety requirements (TSR), and unreviewed safety questions. BJC learned that nuclear safety compliance relies on adequate and well documented system design information. A number of PIS As and TSR violations occurred due to inadequate or erroneous system design information. As a corrective action, BJC assessed the occurrences caused by systems design-safety basis interface problems. Safety systems reviewed included the Molten Salt Reactor Experiment (MSRE) Fluorination System, K-1065 fire alarm system, and the K-25 Radiation Criticality Accident Alarm System. The conclusion was that an inadequate knowledge of system design could result in continuous non-compliance issues relating to nuclear safety. This was especially true with older facilities that lacked current as-built drawings coupled with the loss of 'historical knowledge' as personnel retired or moved on in their careers. Walkdown of systems and the updating of drawings are imperative for nuclear safety compliance. System design integration with safety basis has relevance in the Department of Energy (DOE) complex. This paper presents the BJC Lessons Learned in this area. It will be of benefit to DOE contractors that manage and operate an aging population of nuclear facilities.

  20. 78 FR 23116 - Basis Reporting by Securities Brokers and Basis Determination for Debt Instruments and Options...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-18

    ... broker and for an organizational action that affects the basis of a debt instrument or an option..., ``Report of Organizational Actions Affecting Basis of Securities,'' when revised to request the additional... Department and the IRS have concluded that the best way to balance certainty and flexibility is to require...

  1. 75 FR 6166 - Basis Reporting by Securities Brokers and Basis Determination for Stock

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR Parts, 1, 31, and 301 RIN 1545-Bl66 Basis Reporting by Securities Brokers and Basis Determination for Stock Correction In proposed rule document E9-29855 beginning on...

  2. 75 FR 75896 - Basis Reporting by Securities Brokers and Basis Determination for Stock

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY Internal Revenue Service 26 CFR 1 RIN 1545-BI66 Basis Reporting by Securities Brokers and Basis Determination for Stock Correction In rule document 2010-25504 beginning on page 64072 in the issue of...

  3. The molecular basis of human keratin disorders.

    PubMed

    Arin, Meral Julia

    2009-05-01

    Keratins are cytoskeletal proteins that provide structural support to epithelial cells and tissues. Perturbation causes cell and tissue fragility and accounts for a large number of genetic disorders in humans. In humans, 54 functional keratin genes exist and 21 different keratin genes including hair keratins and hair follicle-specific epithelial keratins have been associated with hereditary disorders. Moreover, keratins have been implicated in more complex traits such as liver disease and inflammatory bowel disease. Understanding the molecular basis of keratin disorders has been the basis for improved diagnosis with prognostic implications, genetic counseling and prenatal testing for severe disorders. Besides their mechanical role, keratins have newly identified functions in apoptosis, cell growth, tissue polarity, wound healing and tissue remodeling. Improved understanding of the regulatory functions of keratins may offer novel approaches to overcome current treatment limitations.

  4. Radioactive Waste Management BasisApril 2006

    SciTech Connect

    Perkins, B K

    2011-08-31

    This Radioactive Waste Management Basis (RWMB) documents radioactive waste management practices adopted at Lawrence Livermore National Laboratory (LLNL) pursuant to Department of Energy (DOE) Order 435.1, Radioactive Waste Management. The purpose of this Radioactive Waste Management Basis is to describe the systematic approach for planning, executing, and evaluating the management of radioactive waste at LLNL. The implementation of this document will ensure that waste management activities at LLNL are conducted in compliance with the requirements of DOE Order 435.1, Radioactive Waste Management, and the Implementation Guide for DOE Manual 435.1-1, Radioactive Waste Management Manual. Technical justification is provided where methods for meeting the requirements of DOE Order 435.1 deviate from the DOE Manual 435.1-1 and Implementation Guide.

  5. The biochemical basis of hereditary fructose intolerance.

    PubMed

    Bouteldja, Nadia; Timson, David J

    2010-04-01

    Hereditary fructose intolerance is a rare, but potentially lethal, inherited disorder of fructose metabolism, caused by mutation of the aldolase B gene. Treatment currently relies solely on dietary restriction of problematic sugars. Biochemical study of defective aldolase B enzymes is key to revealing the molecular basis of the disease and providing a stronger basis for improved treatment and diagnosis. Such studies have revealed changes in enzyme activity, stability and oligomerisation. However, linking these changes to disease phenotypes has not always been straightforward. This review gives a general overview of the features of hereditary fructose intolerance, then concentrates on the biochemistry of the AP variant (Ala149Pro variant of aldolase B) and molecular pathological consequences of mutation of the aldolase B gene.

  6. TECHNICAL BASIS DOCUMENT FOR NATURAL EVENT HAZARDS

    SciTech Connect

    KRIPPS, L.J.

    2006-07-31

    This technical basis document was developed to support the documented safety analysis (DSA) and describes the risk binning process and the technical basis for assigning risk bins for natural event hazard (NEH)-initiated accidents. The purpose of the risk binning process is to determine the need for safety-significant structures, systems, and components (SSC) and technical safety requirement (TSR)-level controls for a given representative accident or represented hazardous conditions based on an evaluation of the frequency and consequence. Note that the risk binning process is not applied to facility workers, because all facility worker hazardous conditions are considered for safety-significant SSCs and/or TSR-level controls.

  7. Minimal Basis for Gauge Theory Amplitudes

    SciTech Connect

    Bjerrum-Bohr, N. E. J.; Damgaard, Poul H.; Vanhove, Pierre

    2009-10-16

    Identities based on monodromy for integrations in string theory are used to derive relations between different color-ordered tree-level amplitudes in both bosonic and supersymmetric string theory. These relations imply that the color-ordered tree-level n-point gauge theory amplitudes can be expanded in a minimal basis of (n-3)exclamation amplitudes. This result holds for any choice of polarizations of the external states and in any number of dimensions.

  8. Component-Based Reduced Basis for Eigenproblems

    DTIC Science & Technology

    2013-07-17

    contributions consider several port economizations (or interface reduction strategies ): an eigenmode expansion (with subsequent truncation) for the port...loss in accuracy of the method. However, we can obtain better results by tailoring the port basis functions to a specific class of problems. A strategy ...for the construction of such empirical port modes is presented in [10]. We briefly describe this strategy here and refer the reader to [10] for further

  9. [Basis of art phonetics in biomedical engineering].

    PubMed

    Chen, Hui; Li, Gelin; Ouyang, Kai; Liu, Yongxiang

    2002-01-01

    Art phonetics' medicine, a new branch of traditional medicine, has not been developed perfectly, especially in the aspects of objective and scientific study. In this paper, the acoustical and anatiomical basis of art phonetics in viewpoint of biomedical engineering is explored, and then our work of quantitative measurement and analysis of art phonetic is introduced. The experiment data show further that quantitative measurement and analysis plays an important role in art phonetic medicine.

  10. Basis-neutral Hilbert-space analyzers

    PubMed Central

    Martin, Lane; Mardani, Davood; Kondakci, H. Esat; Larson, Walker D.; Shabahang, Soroush; Jahromi, Ali K.; Malhotra, Tanya; Vamivakas, A. Nick; Atia, George K.; Abouraddy, Ayman F.

    2017-01-01

    Interferometry is one of the central organizing principles of optics. Key to interferometry is the concept of optical delay, which facilitates spectral analysis in terms of time-harmonics. In contrast, when analyzing a beam in a Hilbert space spanned by spatial modes – a critical task for spatial-mode multiplexing and quantum communication – basis-specific principles are invoked that are altogether distinct from that of ‘delay’. Here, we extend the traditional concept of temporal delay to the spatial domain, thereby enabling the analysis of a beam in an arbitrary spatial-mode basis – exemplified using Hermite-Gaussian and radial Laguerre-Gaussian modes. Such generalized delays correspond to optical implementations of fractional transforms; for example, the fractional Hankel transform is the generalized delay associated with the space of Laguerre-Gaussian modes, and an interferometer incorporating such a ‘delay’ obtains modal weights in the associated Hilbert space. By implementing an inherently stable, reconfigurable spatial-light-modulator-based polarization-interferometer, we have constructed a ‘Hilbert-space analyzer’ capable of projecting optical beams onto any modal basis. PMID:28344331

  11. Biological basis for protection of the environment.

    PubMed

    Larsson, C-M

    2012-01-01

    The approach to protection of the environment may vary considerably depending on ethical basis, methodological approach, and identification of endpoints and protective targets. The International Commission on Radiological Protection (ICRP) reviewed these issues in Publication 91, 'A framework for assessing the impact of ionising radiation on non-human species', published in 2003. At the same time, ICRP proposed that a possible future ICRP system addressing environmental assessment and protection would focus on biota, that the system should be effect-based so that any reasoning about adequate protection would be derived from firm understanding of harm at different exposure levels, and that the system should be based on data sets for Reference Animals and Plants. ICRP has thus chosen to approach environmental protection on the basis of biology, and further developed the approach in Publications 103, 108 and 114. This paper explores the biological basis for the ICRP system of environmental protection from the viewpoints of: the effects endpoints of concern; the hierarchy of biological organisation; adequate and appropriate protective targets; and the derivation of benchmark dose (rates) to guide protective efforts.

  12. Neurobiologic basis of craving for carbohydrates.

    PubMed

    Ventura, Tamara; Santander, Jaime; Torres, Rafael; Contreras, Ana María

    2014-03-01

    There is a relationship between emotional disorders, obesity, and craving for carbohydrates. This relationship complicates the success of treatments aimed at combatting obesity, which is considered to be the epidemic of the twenty-first century. We conducted a review of the neurobiologic basis for carbohydrate craving, with the hope that this understanding will enable the design of more efficient therapeutic strategies. We conducted a non-systematic literature search in PubMed using MeSH. Research on the basis of carbohydrate craving is varied, but may be grouped into five main areas: the serotonergic system, palatability and hedonic response, the motivational system, stress response systems, and gene-environment interaction. The models that integrate motivational systems with palatability and hedonic response studies are the ones that we believe can best explain both craving for carbohydrates and related addictive phenomena. Research has contributed to a greater understanding of the neurobiologic basis of carbohydrate craving. The latter, in turn, contributes to an understanding of the implications, challenges, and possible therapies that might be put in place to cope with this phenomenon. Copyright © 2014 Elsevier Inc. All rights reserved.

  13. The genetic basis of pachyonychia congenita.

    PubMed

    Smith, Frances J D; Liao, Haihui; Cassidy, Andrew J; Stewart, Arlene; Hamill, Kevin J; Wood, Pamela; Joval, Iris; van Steensel, Maurice A M; Björck, Erik; Callif-Daley, Faith; Pals, Gerald; Collins, Paul; Leachman, Sancy A; Munro, Colin S; McLean, W H Irwin

    2005-10-01

    In 1994, the molecular basis of pachyonychia congenita (PC) was elucidated. Four keratin genes are associated with the major subtypes of PC: K6a or K16 defects cause PC-1; and mutations in K6b or K17 cause PC-2. Mutations in keratins, the epithelial-specific intermediate filament proteins, result in aberrant cytoskeletal networks which present clinically as a variety of epithelial fragility phenotypes. To date, mutations in 20 keratin genes are associated with human disorders. Here, we review the genetic basis of PC and report 30 new PC mutations. Of these, 25 mutations were found in PC-1 families and five mutations were identified in PC-2 kindreds. All mutations identified were heterozygous amino acid substitutions or small in-frame deletion mutations with the exception of an unusual mutation in a sporadic case of PC-1. The latter carried a 117 bp duplication resulting in a 39 amino acid insertion in the 2B domain of K6a. Also of note was mutation L388P in K17, which is the first genetic defect identified in the helix termination motif of this protein. Understanding the genetic basis of these disorders allows better counseling for patients and paves the way for therapy development.

  14. The molecular basis of intervertebral disc degeneration.

    PubMed

    Kepler, Christopher K; Ponnappan, Ravi K; Tannoury, Chadi A; Risbud, Marakand V; Anderson, David G

    2013-03-01

    Intervertebral disc (IVD) degeneration remains a clinically important condition for which treatment is costly and relatively ineffective. The molecular basis of degenerative disc disease has been an intense focus of research recently, which has greatly increased our understanding of the biology underlying this process. To review the current understanding of the molecular basis of disc degeneration. Review article. A literature review was performed to identify recent investigations and current knowledge regarding the molecular basis of IVD degeneration. The unique structural requirements and biochemical properties of the disc contribute to its propensity toward degeneration. Mounting evidence suggests that genetic factors account for up to 75% of individual susceptibility to IVD degeneration, far more than the environmental factors such as occupational exposure or smoking that were previously suspected to figure prominently in this process. Decreased extracellular matrix production, increased production of degradative enzymes, and increased expression of inflammatory cytokines contribute to the loss of structural integrity and accelerate IVD degeneration. Neurovascular ingrowth occurs, in part, because of the changing degenerative phenotype. A detailed understanding of the biology of IVD degeneration is essential to the design of therapeutic solutions to treat degenerative discs. Although significant advances have been made in explaining the biologic mediators of disc degeneration, the inhospitable biochemical environment of the IVD remains a challenging environment for biological therapies. Copyright © 2013 Elsevier Inc. All rights reserved.

  15. The molecular basis of frontotemporal dementia.

    PubMed

    Neumann, Manuela; Tolnay, Markus; Mackenzie, Ian R A

    2009-07-29

    Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular basis. Familial FTD has been linked to mutations in several genes, including those encoding the microtubule-associated protein tau (MAPT), progranulin (GRN), valosin-containing protein (VCP) and charged multivescicular body protein 2B (CHMP2B). The associated neuropathology is characterised by selective degeneration of the frontal and temporal lobes (frontotemporal lobar degeneration, FTLD), usually with the presence of abnormal intracellular protein accumulations. The current classification of FTLD neuropathology is based on the identity of the predominant protein abnormality, in the belief that this most closely reflects the underlying pathogenic process. Major subgroups include those characterised by the pathological tau, TDP-43, intermediate filaments and a group with cellular inclusions composed of an unidentified ubiquitinated protein. This review will focus on the current understanding of the molecular basis of each of the major FTLD subtypes. It is anticipated that this knowledge will provide the basis of future advances in the diagnosis and treatment of FTD.

  16. Accurate basis set truncation for wavefunction embedding

    NASA Astrophysics Data System (ADS)

    Barnes, Taylor A.; Goodpaster, Jason D.; Manby, Frederick R.; Miller, Thomas F.

    2013-07-01

    Density functional theory (DFT) provides a formally exact framework for performing embedded subsystem electronic structure calculations, including DFT-in-DFT and wavefunction theory-in-DFT descriptions. In the interest of efficiency, it is desirable to truncate the atomic orbital basis set in which the subsystem calculation is performed, thus avoiding high-order scaling with respect to the size of the MO virtual space. In this study, we extend a recently introduced projection-based embedding method [F. R. Manby, M. Stella, J. D. Goodpaster, and T. F. Miller III, J. Chem. Theory Comput. 8, 2564 (2012)], 10.1021/ct300544e to allow for the systematic and accurate truncation of the embedded subsystem basis set. The approach is applied to both covalently and non-covalently bound test cases, including water clusters and polypeptide chains, and it is demonstrated that errors associated with basis set truncation are controllable to well within chemical accuracy. Furthermore, we show that this approach allows for switching between accurate projection-based embedding and DFT embedding with approximate kinetic energy (KE) functionals; in this sense, the approach provides a means of systematically improving upon the use of approximate KE functionals in DFT embedding.

  17. Optimal ratio between phase basis and bit basis in quantum key distributions

    NASA Astrophysics Data System (ADS)

    Hayashi, Masahito

    2009-02-01

    In the original Bennett-Brassard 1984 protocol, the bit basis and the phase basis are used with equal probability. Lo [J. Cryptology 18, 133 (2005)] proposed modifying the ratio between the two bases by increasing the final key generation rate. However, the optimum ratio has not yet been derived. In this Rapid Communication, in order to examine this problem, the ratio between the two bases is optimized for exponential constraints, given Eve’s information distinguishability and the final error probability.

  18. Graph-state basis for Pauli channels

    SciTech Connect

    Chen Xiaoyu; Jiang Lizhen

    2011-05-15

    Quantum capacities of Pauli channels are not additive, a degenerate quantum code may improve the hashing bound of the capacity. The difficulty in approaching the capacity is how to calculate the coherent information of a generic degenerate quantum code. Using graph state basis, we greatly reduce the problem for the input of quantum error-correcting code. We show that for a graph diagonal state passing through a Pauli channel the output state is diagonalizable and the joint output state of the system and ancilla is block diagonalizable. When the input state is an equal probable mixture of codewords of a stabilizer code, the coherent information can be analytically obtained.

  19. The Molecular Basis of β-Thalassemia

    PubMed Central

    Thein, Swee Lay

    2013-01-01

    The β-thalassemias are characterized by a quantitative deficiency of β-globin chains underlaid by a striking heterogeneity of molecular defects. Although most of the molecular lesions involve the structural β gene directly, some down-regulate the gene through distal cis effects, and rare trans-acting mutations have also been identified. Most β-thalassemias are inherited in a Mendelian recessive fashion but there is a subgroup of β-thalassemia alleles that behave as dominant negatives. Unraveling the molecular basis of β-thalassemia has provided a paradigm for understanding of much of human genetics. PMID:23637309

  20. Chopped random-basis quantum optimization

    SciTech Connect

    Caneva, Tommaso; Calarco, Tommaso; Montangero, Simone

    2011-08-15

    In this work, we describe in detail the chopped random basis (CRAB) optimal control technique recently introduced to optimize time-dependent density matrix renormalization group simulations [P. Doria, T. Calarco, and S. Montangero, Phys. Rev. Lett. 106, 190501 (2011)]. Here, we study the efficiency of this control technique in optimizing different quantum processes and we show that in the considered cases we obtain results equivalent to those obtained via different optimal control methods while using less resources. We propose the CRAB optimization as a general and versatile optimal control technique.

  1. Neurobiological Basis of Language Learning Difficulties.

    PubMed

    Krishnan, Saloni; Watkins, Kate E; Bishop, Dorothy V M

    2016-09-01

    In this paper we highlight why there is a need to examine subcortical learning systems in children with language impairment and dyslexia, rather than focusing solely on cortical areas relevant for language. First, behavioural studies find that children with these neurodevelopmental disorders perform less well than peers on procedural learning tasks that depend on corticostriatal learning circuits. Second, fMRI studies in neurotypical adults implicate corticostriatal and hippocampal systems in language learning. Finally, structural and functional abnormalities are seen in the striatum in children with language disorders. Studying corticostriatal networks in developmental language disorders could offer us insights into their neurobiological basis and elucidate possible modes of compensation for intervention.

  2. Genomic basis of evolutionary change: evolving immunity

    PubMed Central

    Wertheim, Bregje

    2015-01-01

    Complex traits are manifestations of intricate gene interaction networks. Evolution of complex traits revolves around the genetic variation in such networks. Genomics has increased our ability to investigate the complex gene interaction networks, and characterize the extent of genetic variation in these networks. Immunity is a complex trait, for which the ecological drivers and molecular networks are fairly well understood in Drosophila. By characterizing the natural variation in immunity, and mapping how the genome changes during the evolution of immunity in Drosophila, we can integrate our knowledge on the complex genetic architecture of traits and the molecular basis of evolutionary processes. PMID:26150830

  3. New basis function distortion invariant detection filters

    NASA Astrophysics Data System (ADS)

    Iyer, Anand K.; Casasent, David P.

    1994-09-01

    New correlation filters for object detection are considered. Detection is the first step in general scene analysis. It requires locating the positions of all objects (regions of interest) in a scene. This involves recognizing objects in multiple classes with object distortion and contrast differences in the presence of clutter. To solve this problem, we use basis function descriptions of objects using new Gabor wavelet (CW) filter functions with new correlation plane optimization functions and employ degrees of freedom (DOFs) to satisfy the optimization functions in a controlled manner. We refer to these as DOF filters and to our specific versions as GW-DOF filters.

  4. Genetic Basis for Colorectal Cancer Disparities

    PubMed Central

    Nayani, Rahul; Ashktorab, Hassan; Brim, Hassan; Laiyemo, Adeyinka O.

    2015-01-01

    African Americans suffer the highest burden from colorectal cancer (CRC) in the USA. Studies have suggested that healthcare access and poorer utilization of preventive services may be playing more of a role in this disparity. However, African Americans also tend to develop CRC at younger ages and are more likely to have proximal cancers. This raises the possibility of higher genetic predisposition to CRC among African Americans and this has not been well studied. In this article, we reviewed possible genetic basis underpinning biological differences in CRC burden in the USA. PMID:26997937

  5. Technical basis for internal dosimetry at Hanford

    SciTech Connect

    Sula, M.J.; Carbaugh, E.H.; Bihl, D.E.

    1989-04-01

    The Hanford Internal Dosimetry Program, administered by Pacific Northwest Laboratory for the US Department of Energy, provides routine bioassay monitoring for employees who are potentially exposed to radionuclides in the workplace. This report presents the technical basis for routine bioassay monitoring and the assessment of internal dose at Hanford. The radionuclides of concern include tritium, corrosion products (/sup 58/Co, /sup 60/Co, /sup 54/Mn, and /sup 59/Fe), strontium, cesium, iodine, europium, uranium, plutonium, and americium. Sections on each of these radionuclides discuss the sources and characteristics; dosimetry; bioassay measurements and monitoring; dose measurement, assessment, and mitigation; and bioassay follow-up treatment. 64 refs., 42 figs., 118 tabs.

  6. Technical basis for internal dosimetry at Hanford

    SciTech Connect

    Sula, M.J.; Carbaugh, E.H.; Bihl, D.E.

    1991-07-01

    The Hanford Internal Dosimetry Program, administered by Pacific Northwest Laboratory for the US Department of Energy, provides routine bioassay monitoring for employees who are potentially exposed to radionuclides in the workplace. This report presents the technical basis for routine bioassay monitoring and the assessment of internal dose at Hanford. The radionuclides of concern include tritium, corrosion products ({sup 58}Co, {sup 60}Co, {sup 54}Mn, and {sup 59}Fe), strontium, cesium, iodine, europium, uranium, plutonium, and americium,. Sections on each of these radionuclides discuss the sources and characteristics; dosimetry; bioassay measurements and monitoring; dose measurement, assessment, and mitigation and bioassay follow-up treatment. 78 refs., 35 figs., 115 tabs.

  7. Reduced Basis Method for Nanodevices Simulation

    SciTech Connect

    Pau, George Shu Heng

    2008-05-23

    Ballistic transport simulation in nanodevices, which involves self-consistently solving a coupled Schrodinger-Poisson system of equations, is usually computationally intensive. Here, we propose coupling the reduced basis method with the subband decomposition method to improve the overall efficiency of the simulation. By exploiting a posteriori error estimation procedure and greedy sampling algorithm, we are able to design an algorithm where the computational cost is reduced significantly. In addition, the computational cost only grows marginally with the number of grid points in the confined direction.

  8. Modelling erosion on a daily basis

    NASA Astrophysics Data System (ADS)

    Pikha Shrestha, Dhruba; Jetten, Victor

    2016-04-01

    Effect of soil erosion causing negative impact on ecosystem services and food security is well known. To assess annual erosion rates various empirical models have been extensively used in all the climatic regions. While these models are simple to operate and do not require lot of input data, the effect of extreme rain is not taken into account in the annual estimations. For analysing the effects of extreme rain the event- based models become handy. These models can simulate detail erosional processes including particle detachment, transportation and deposition of sediments during a storm. But they are not applicable for estimating annual erosion rates. Moreover storm event data may not be available everywhere which prohibits their extensive use. In this paper we describe a method by adapting the revised MMF model to assess erosion on daily basis so that the effects of extreme rains are taken into account. We couple it to a simple surface soil moisture balance on a daily basis and include estimation of daily vegetation cover changes. Annual soil loss is calculated by adding daily erosion rates. We compare the obtained results with that obtained from applying the revised MMF model in a case study in the Mamora plateau in northwest Morocco which is affected by severe gully formation. The results show clearly the effects of exceptional rain in erosional processes which cannot be captured in an annual model.

  9. Flat parlog: a basis for comparison

    SciTech Connect

    Foster, I.; Taylor, S.

    1987-04-01

    Three similar parallel logic programming languages have been proposed; Parlog, Flat Concurrent Prolog, and Guarded Horn Clauses. Quantitative comparison of the languages has not previously been possible since they employ different execution models and implementation techniques. In order to uncover the effects of semantic differences on efficiency, a common basis is required for experimentation. This paper presents a subset of the language Parlog called Flat Parlog which provides a basis for quantitative comparison. The language combines the directional semantics of Parlog with the simple execution model of Flat Concurrent Prolog. A performance comparison between Flat Parlog and Flat Concurrent Prolog based on new implementations of both languages is presented. These new implementations are identical except for optimizations that are possible by virtue of semantic differences. Benchmark results indicate that Flat Parlog is more efficient; experiments have been able to quantify and explain this performance differential. A detailed description of the abstract machine for Flat Parlog is presented to illustrate the simplicity of the language.

  10. The entropic basis of collective behaviour

    PubMed Central

    Mann, Richard P.; Garnett, Roman

    2015-01-01

    We identify a unique viewpoint on the collective behaviour of intelligent agents. We first develop a highly general abstract model for the possible future lives these agents may encounter as a result of their decisions. In the context of these possibilities, we show that the causal entropic principle, whereby agents follow behavioural rules that maximize their entropy over all paths through the future, predicts many of the observed features of social interactions among both human and animal groups. Our results indicate that agents are often able to maximize their future path entropy by remaining cohesive as a group and that this cohesion leads to collectively intelligent outcomes that depend strongly on the distribution of the number of possible future paths. We derive social interaction rules that are consistent with maximum entropy group behaviour for both discrete and continuous decision spaces. Our analysis further predicts that social interactions are likely to be fundamentally based on Weber's law of response to proportional stimuli, supporting many studies that find a neurological basis for this stimulus–response mechanism and providing a novel basis for the common assumption of linearly additive ‘social forces’ in simulation studies of collective behaviour. PMID:25833243

  11. Molecular Basis of Actin Nucleation Factor Cooperativity

    PubMed Central

    Zeth, Kornelius; Pechlivanis, Markos; Samol, Annette; Pleiser, Sandra; Vonrhein, Clemens; Kerkhoff, Eugen

    2011-01-01

    The distinct actin nucleation factors of the Spir and formin subgroup families cooperate in actin nucleation. The Spir/formin cooperativity has been identified to direct two essential steps in mammalian oocyte maturation, the asymmetric spindle positioning and polar body extrusion during meiosis. Understanding the nature and regulation of the Spir/Fmn cooperation is an important requirement to comprehend mammalian reproduction. Recently we dissected the structural elements of the Spir and Fmn family proteins, which physically link the two actin nucleation factors. The trans-regulatory interaction is mediated by the Spir kinase non-catalytic C-lobe domain (KIND) and the C-terminal formin Spir interaction motif (FSI). The interaction inhibits formin nucleation activity and enhances the Spir activity. To get insights into the molecular mechanism of the Spir/Fmn interaction, we determined the crystal structure of the KIND domain alone and in complex with the C-terminal Fmn-2 FSI peptide. Together they confirm the proposed structural homology of the KIND domain to the protein kinase fold and reveal the basis of the Spir/formin interaction. The complex structure showed a large interface with conserved and positively charged residues of the Fmn FSI peptide mediating major contacts to an acidic groove on the surface of KIND. Protein interaction studies verified the electrostatic nature of the interaction. The data presented here provide the molecular basis of the Spir/formin interaction and give a first structural view into the mechanisms of actin nucleation factor cooperativity. PMID:21705804

  12. Technical Basis for PNNL Beryllium Inventory

    SciTech Connect

    Johnson, Michelle Lynn

    2014-07-09

    The Department of Energy (DOE) issued Title 10 of the Code of Federal Regulations Part 850, “Chronic Beryllium Disease Prevention Program” (the Beryllium Rule) in 1999 and required full compliance by no later than January 7, 2002. The Beryllium Rule requires the development of a baseline beryllium inventory of the locations of beryllium operations and other locations of potential beryllium contamination at DOE facilities. The baseline beryllium inventory is also required to identify workers exposed or potentially exposed to beryllium at those locations. Prior to DOE issuing 10 CFR 850, Pacific Northwest Nuclear Laboratory (PNNL) had documented the beryllium characterization and worker exposure potential for multiple facilities in compliance with DOE’s 1997 Notice 440.1, “Interim Chronic Beryllium Disease.” After DOE’s issuance of 10 CFR 850, PNNL developed an implementation plan to be compliant by 2002. In 2014, an internal self-assessment (ITS #E-00748) of PNNL’s Chronic Beryllium Disease Prevention Program (CBDPP) identified several deficiencies. One deficiency is that the technical basis for establishing the baseline beryllium inventory when the Beryllium Rule was implemented was either not documented or not retrievable. In addition, the beryllium inventory itself had not been adequately documented and maintained since PNNL established its own CBDPP, separate from Hanford Site’s program. This document reconstructs PNNL’s baseline beryllium inventory as it would have existed when it achieved compliance with the Beryllium Rule in 2001 and provides the technical basis for the baseline beryllium inventory.

  13. The genetic basis of white tigers.

    PubMed

    Xu, Xiao; Dong, Gui-Xin; Hu, Xue-Song; Miao, Lin; Zhang, Xue-Li; Zhang, De-Lu; Yang, Han-Dong; Zhang, Tian-You; Zou, Zheng-Ting; Zhang, Ting-Ting; Zhuang, Yan; Bhak, Jong; Cho, Yun Sung; Dai, Wen-Tao; Jiang, Tai-Jiao; Xie, Can; Li, Ruiqiang; Luo, Shu-Jin

    2013-06-03

    The white tiger, an elusive Bengal tiger (Panthera tigris tigris) variant with white fur and dark stripes, has fascinated humans for centuries ever since its discovery in the jungles of India. Many white tigers in captivity are inbred in order to maintain this autosomal recessive trait and consequently suffer some health problems, leading to the controversial speculation that the white tiger mutation is perhaps a genetic defect. However, the genetic basis of this phenotype remains unknown. Here, we conducted genome-wide association mapping with restriction-site-associated DNA sequencing (RAD-seq) in a pedigree of 16 captive tigers segregating at the putative white locus, followed by whole-genome sequencing (WGS) of the three parents. Validation in 130 unrelated tigers identified the causative mutation to be an amino acid change (A477V) in the transporter protein SLC45A2. Three-dimensional homology modeling suggests that the substitution may partially block the transporter channel cavity and thus affect melanogenesis. We demonstrate the feasibility of combining RAD-seq and WGS to rapidly map exotic variants in nonmodel organisms. Our results identify the basis of the longstanding white tiger mystery as the same gene underlying color variation in human, horse, and chicken and highlight its significance as part of the species' natural polymorphism that is viable in the wild. Copyright © 2013 Elsevier Ltd. All rights reserved.

  14. The Molecular Basis of Human Brain Evolution.

    PubMed

    Enard, Wolfgang

    2016-10-24

    Humans are a remarkable species, especially because of the remarkable properties of their brain. Since the split from the chimpanzee lineage, the human brain has increased three-fold in size and has acquired abilities for vocal learning, language and intense cooperation. To better understand the molecular basis of these changes is of great biological and biomedical interest. However, all the about 16 million fixed genetic changes that occurred during human evolution are fully correlated with all molecular, cellular, anatomical and behavioral changes that occurred during this time. Hence, as humans and chimpanzees cannot be crossed or genetically manipulated, no direct evidence for linking particular genetic and molecular changes to human brain evolution can be obtained. Here, I sketch a framework how indirect evidence can be obtained and review findings related to the molecular basis of human cognition, vocal learning and brain size. In particular, I discuss how a comprehensive comparative approach, leveraging cellular systems and genomic technologies, could inform the evolution of our brain in the future. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. A Neural Basis for Contagious Yawning.

    PubMed

    Brown, Beverley J; Kim, Soyoung; Saunders, Hannah; Bachmann, Clarissa; Thompson, Jessica; Ropar, Danielle; Jackson, Stephen R; Jackson, Georgina M

    2017-09-11

    Contagious yawning, in which yawning is triggered involuntarily when we observe another person yawn, is a common form of echophenomena-the automatic imitation of another's words (echolalia) or actions (echopraxia) [1]. The neural basis for echophenomena is unknown; however, it has been proposed that it is linked to disinhibition of the human mirror-neuron system [1-4] and hyper-excitability of cortical motor areas [1]. We investigated the neural basis for contagious yawning using transcranial magnetic stimulation (TMS). Thirty-six adults viewed video clips that showed another individual yawning and, in separate blocks, were instructed to either resist yawning or allow themselves to yawn. Participants were videoed throughout and their yawns or stifled yawns were counted. We used TMS to quantify motor cortical excitability and physiological inhibition for each participant, and these measures were then used to predict the propensity for contagious yawning across participants. We demonstrate that instructions to resist yawning increase the urge to yawn and alter how yawns are expressed (i.e., full versus stifled yawns) but do not alter the individual propensity for contagious yawning. By contrast, TMS measures of cortical excitability and physiological inhibition were significant predictors of contagious yawning and accounted for approximately 50% of the variability in contagious yawning. These data demonstrate that individual variability in the propensity for contagious yawning is determined by cortical excitability and physiological inhibition in the primary motor cortex. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  16. The Biological Basis to Personality Disorders.

    PubMed

    Perugula, Malathi L; Narang, Puneet D; Lippmann, Steven B

    2017-04-13

    To provide understanding into the biological basis of thinking and behavior in people with personality disorders, explain anatomic findings, and appraise therapeutic options. PubMed was searched with no date restrictions using the terms personality disorders DSM-5, cluster B personality disorders, biological psychiatry of personality disorders, neurobiology of personality disorders, and neurobiology of cluster B personality disorders. We identified 2,790 English-language articles and utilized 18 in this report. There are anatomic features typical to the brains of individuals with cluster B personality disorders, for example, abnormalities in the superior frontal cortex and amygdala and enlarged striatal volumes. Emotional dysregulation and impulsiveness are 2 prominent symptoms. Hereditary factors may contribute to the development of such conditions. Understanding the neurobiology of cluster B personality disorders expands knowledge that hopefully results in better clinical management and development of improved treatments. Psychotherapy is currently the most effective intervention for borderline personality disorders. Symptomatic pharmacotherapies may be prescribed adjunctively on an individualized basis if clinically indicated (eg, with a coexistant depression).

  17. Genetic Basis of Mitochondrial Optic Neuropathies.

    PubMed

    Maresca, A; Caporali, L; Strobbe, D; Zanna, C; Malavolta, D; La Morgia, C; Valentino, M L; Carelli, V

    2014-01-01

    Over two decades have elapsed since the first mtDNA point mutation was associated with Leber's hereditary optic neuropathy (LHON) in 1988. We have subsequently witnessed a substantial understanding of the molecular basis of hereditary optic neuropathies, as well as of their clinical features and pathogenic mechanisms. It became clear that the large majority of genetic optic neuropathies have a primary or an indirect involvement of mitochondrial functions, justifying the definition of "mitochondrial optic neuropathies". Despite this progress many unsolved features remain to be understood, such as incomplete penetrance and variable clinical expressivity in LHON and dominant optic atrophy (DOA), gender prevalence in LHON, and complex gene/environment interactions in both LHON and DOA. The most recent advancement in our understanding of the molecular basis of mitochondrial optic neuropathies is the topic of this review. In particular, we analyze the role that mitochondrial biogenesis may play in the compensatory mechanisms that underlie incomplete penetrance and clinical expressivity, a scenario relevant for the possible design of future therapeutic approaches. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  18. 26 CFR 1.737-3 - Basis adjustments; Recovery rules.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Basis adjustments; Recovery rules. 1.737-3...; Recovery rules. (a) Distributee partner's adjusted tax basis in the partnership interest. The distributee...) Recovery of increase to adjusted tax basis. Any increase to the adjusted tax basis of partnership...

  19. 26 CFR 1.737-3 - Basis adjustments; Recovery rules.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Basis adjustments; Recovery rules. 1.737-3... TAX (CONTINUED) INCOME TAXES Distributions by A Partnership § 1.737-3 Basis adjustments; Recovery...) Recovery of increase to adjusted tax basis. Any increase to the adjusted tax basis of partnership...

  20. The molecular basis of myelodysplastic syndromes.

    PubMed

    Gallagher, A; Darley, R L; Padua, R

    1997-01-01

    The myelodysplastic syndromes comprise a heterogeneous group of neoplastic disorders characterized by ineffective hematopoiesis with an increased tendency to evolve to acute leukemia. Clinically, the common manifestations include peripheral blood cytopenias of one or more lineages and a normal to hyperplastic marrow. MDS has been defined on the basis of morphological criteria, namely the percentage of blast cells in the bone marrow, by the French-American-British study group. Scoring systems have been developed to include such factors as hemoglobin, leukocyte count and age in the evaluation of MDS prognosis. Although useful in the prediction of clinical course and design of therapy regimens, our understanding of the basis of MDS has come from recent advances in molecular analysis of these disorders. This review describes some of the established and recent contributions to our understanding of the molecular basis of the myelodysplastic syndromes. The authors of the present review have been working in the field of myelodysplastic syndromes for several years and have contributed original papers on the molecular pathogenesis of these disorders. In addition, in the present review they have critically examined articles and abstracts published in journals covered by the Science Citation Index and Medline. Cytogenetic anomalies and proto-oncogene abnormalities point to new understanding of the pathogenesis of MDS as a sequence of DNA lesions leading to the evolution of the pre-malignant clone. The prognostic significance of these factors in predicting leukemic transformation and survival remains controversial. Characterization of MDS cells in vitro in response to combinations of exogenous growth factors have not only provided valuable information regarding ineffective hematopoiesis in MDS but have provided a new insight into treatment of MDS. One major development in our understanding of MDS is the possible explanation for the apparent paradox of a cellular marrow in

  1. FAUST: Entwicklung von Fahrerassistenz- und autonomen Systemen

    NASA Astrophysics Data System (ADS)

    Pareigis, Stephan; Schwarz, Bernd; Korf, Franz

    Der Beitrag beschreibt ein Ausbildungs- und Entwicklungsprojekt am Department Informatik der Hochschule für Angewandte Wissenschaften (HAW) Hamburg. Auf verschiedenen Fahrzeugplattformen werden Fahrerassistenz- und autonome Systeme entwickelt. Die zu erarbeitenden Inhalte umfassen die Themen verteilte Echtzeitsysteme, Sensordatenverarbeitung und Bildverarbeitung. Aus didaktischer Sicht wird durch die geforderte Teamarbeit ein hohes Motivationspotential der Studierenden erreicht, durch das neben den technologischen Kenntnissen auch Softskills vermittelt werden.

  2. Zur Entwicklung der medizinischen Wissenschaften in China

    NASA Astrophysics Data System (ADS)

    Müller, Hans Kurt

    1980-02-01

    Three periods or stages can be recognized in the development of medicine in China. The first one, being the indigenous medical practice, has its own philosophical approach and can therefore not simply be combined with Western medicine. The second period, in which medical missionaries introduced modern medicine was still a time of laissez-faire and pestilence. The third stage was ushered in by the liberation in 1949 and is characterized by the fact that the government no longer regards health as the private affair of the individual but as a task for the whole community. A number of endemic and epidemic diseases were conquered mainly through close cooperation between the population and medical workers. Success must be regarded as in an important part due to land reform and the eradication of famine. Further improvement in health care will depend to a great deal on improvement in living standards and a lessening of population pressure. As family planning meets resistance for economic and other reasons, only specific measures by the state can bring about a change in attitude. The progress in preventive measures is matched by advances in the technical aspects of medicine and especially too in medical education.

  3. The scientific basis for patient blood management.

    PubMed

    Murphy, M F; Goodnough, L T

    2015-08-01

    Patient blood management is an increasingly used term to describe an evidence-based, multidisciplinary approach to optimising the care of patients who might need transfusion. It encompasses measures to avoid transfusion such as anaemia management without transfusion, cell salvage and the use of anti-fibrinolytic drugs to reduce bleeding as well as restrictive transfusion. It ensures that patients receive the optimal treatment, and that avoidable, inappropriate use of blood and blood components is reduced. This paper provides an overview of the scientific basis for patient blood management with a focus on the increasing evidence for restrictive rather than liberal transfusion practice and the use of electronic blood ordering and decision support to facilitate its implementation. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  4. Height as a basis for interpersonal attraction.

    PubMed

    Hensley, W E

    1994-01-01

    Beginning with the observation of a male-taller basis in date/mate selection, this study investigated a complementary vs. a step function in choosing a dating partner. In addition, the relative advantages or disadvantages of height were examined for both genders in the dating marketplace. Our sample of college students (N = 594) indicated that while we may use a complementary standard in hypothetical date selection, the actual height of a chosen person is more likely to be made on a step function. Second, there appears to be no dating consequences for a female in a height-related sense, but taller males do enjoy a noticeable dating advantage. Finally, there appears to be a "ceiling effect" demonstrated here for the first time; the height advantage for a male seems to diminish when he is taller than six feet. Suggestions are offered which integrate the present findings into past research.

  5. Technical basis for chemical stockpile emergency planning

    SciTech Connect

    Newsom, D.E.; Madore, M.A.; Paddock, R.A.; Absil, M.J.G.

    1995-12-31

    As part of the Chemical Stockpile Emergency Preparedness Program, an Accident Planning Base Review Group (APBRG) was convened in December 1992. The APBRG`s mission was to update the accident basis for protective action strategy planning in the vicinity of eight US chemical agent stockpile sites. The results of the APBRG`s work are being issued as site-specific Emergency Planning Guides (EPGs). The EPGs give emergency planners -- Army, State, and local -- an updated assessment of the chemical hazard and guidance on how to plan for a broad range of accidents by planning for a manageable number of accident categories. This paper addresses: the rationale for updating the accident planning base, the modeling methodology used to assess the chemical hazard, and strategies that are advocated in the EPGs for the use of models by planners.

  6. Anatomical basis of pedicles in breast reduction

    PubMed Central

    Coscarelli, Leonardo; Rancati, Alberto

    2017-01-01

    The mammary gland is composed of multiple tubules acinar pockets in which the secretory layer, connective tissue stroma, and fatty tissue all respond to hormonal and systemic influences. These structures are irrigated by three vascular pedicle branches, from the axillary artery, internal mammary artery, and intercostal artery. This vascular anastomotic arrangement forms the anatomical basis of the flaps used in breast reduction techniques. The veins form a strong subdermal network, latticed with the arterial network. The lymph vessels have three well-defined pedicles, skin, glandular and milk ducts that drain into internal, external, and posterior ducts. The understanding of these anatomical structures determines the selection of different pedicles in breast volume reduction and preservation of the nipple-areola complex circulation. PMID:28497019

  7. Technical basis for chemical stockpile emergency planning

    SciTech Connect

    Newsom, D.E.; Madore, M.A.; Paddock, R.A.; Absil, M.J.G.

    1995-06-01

    As part of the Chemical Stockpile Emergency Preparedness Program, an Accident Planning Base Review Group (APBRG) was convened in December 1992. The APBRG`s mission was to update the accident basis for protective action strategy planning in the vicinity of eight US chemical agent stockpile sites. The results of the APBRG`s work are being issued as site-specific Emergency Planning Guides (EPGs). The EPGs give emergency planners--Army, State, and local--updated assessment of the chemical hazard and guidance on how to plan for a broad range of accidents by planning for a manageable number of accident categories. This paper addresses: (1) the rationale for updating the accident planning base; (2) the modeling methodology used to assess the chemical hazard; and (3) strategies that are advocated in the EPGs for the use of models by planners.

  8. Molecular basis of chloroplast photorelocation movement.

    PubMed

    Kong, Sam-Geun; Wada, Masamitsu

    2016-03-01

    Chloroplast photorelocation movement is an essential physiological response for sessile plant survival and the optimization of photosynthetic ability. Simple but effective experiments on the physiological, cell biological and molecular genetic aspects have been widely used to investigate the signaling components of chloroplast photorelocation movement in Arabidopsis for the past few decades. Although recent knowledge on chloroplast photorelocation movement has led us to a deeper understanding of its physiological and molecular basis, the biochemical roles of the downstream factors remain largely unknown. In this review, we briefly summarize recent advances regarding chloroplast photorelocation movement and propose that a new high-resolution approach is necessary to investigate the molecular mechanism underlying actin-based chloroplast photorelocation movement.

  9. The molecular basis of genetic dominance.

    PubMed Central

    Wilkie, A O

    1994-01-01

    Studies of mutagenesis in many organisms indicate that the majority (over 90%) of mutations are recessive to wild type. If recessiveness represents the 'default' state, what are the distinguishing features that make a minority of mutations give rise to dominant or semidominant characters? This review draws on the rapid expansion in knowledge of molecular and cellular biology to classify the molecular mechanisms of dominant mutation. The categories discussed include (1) reduced gene dosage, expression, or protein activity (haploinsufficiency); (2) increased gene dosage; (3) ectopic or temporally altered mRNA expression; (4) increased or constitutive protein activity; (5) dominant negative effects; (6) altered structural proteins; (7) toxic protein alterations; and (8) new protein functions. This provides a framework for understanding the basis of dominant genetic phenomena in humans and other organisms. Images PMID:8182727

  10. Attachment theory: a biological basis for psychotherapy?

    PubMed

    Holmes, J

    1993-10-01

    John Bowlby bemoaned the separation between the biological and psychological approaches in psychiatry, and hoped that attachment theory, which brings together psychoanalysis and the science of ethology, would help bridge the rift between them. Recent findings in developmental psychology have delineated features of parent-infant interaction, especially responsiveness, attunement, and modulation of affect, which lead to either secure or insecure attachment. Similar principles can be applied to the relationship between psychotherapist and patient--the provision of a secure base, the emergence of a shared narrative ('autobiographical competence'), the processing of affect, coping with loss--these are common to most effective psychotherapies and provide the basis for a new interpersonal paradigm within psychotherapy. Attachment theory suggests they rest on a sound ethological and hence biological foundation.

  11. The Metabolic Basis of Kidney Cancer

    PubMed Central

    Linehan, W. Marston; Ricketts, Christopher J.

    2012-01-01

    Kidney cancer is not a single disease; it is made up of a number of different types of cancer that occur in the kidney. Each of these different types of kidney cancer can have a different histology, have a different clinical course, can respond differently to therapy and is caused by a different gene. Kidney cancer is essentially a metabolic disease; each of the known genes for kidney cancer, VHL, MET, FLCN, TSC1, TSC2, TFE3, TFEB, MITF, fumarate hydratase (FH), succinate dehydrogenase B (SDHB), succinate dehydrogenase D (SDHD), and PTEN genes is involved in the cells ability to sense oxygen, iron, nutrients or energy. Understanding the metabolic basis of kidney cancer will hopefully provide the foundation for the development of effective forms of therapy for this disease. PMID:22705279

  12. Framing effects: behavioral dynamics and neural basis.

    PubMed

    Zheng, Hongming; Wang, X T; Zhu, Liqi

    2010-09-01

    This study examined the neural basis of framing effects using life-death decision problems framed either positively in terms of lives saved or negatively in terms of lives lost in large group and small group contexts. Using functional MRI we found differential brain activations to the verbal and social cues embedded in the choice problems. In large group contexts, framing effects were significant where participants were more risk seeking under the negative (loss) framing than under the positive (gain) framing. This behavioral difference in risk preference was mainly regulated by the activation in the right inferior frontal gyrus, including the homologue of the Broca's area. In contrast, framing effects diminished in small group contexts while the insula and parietal lobe in the right hemisphere were distinctively activated, suggesting an important role of emotion in switching choice preference from an indecisive mode to a more consistent risk-taking inclination, governed by a kith-and-kin decision rationality.

  13. Biochemical Basis of Sestrin Physiological Activities

    SciTech Connect

    Ho, Allison; Cho, Chun-Seok; Namkoong, Sim; Cho, Uhn-Soo; Lee, Jun Hee

    2016-05-10

    Excessive accumulation of reactive oxygen species (ROS) and chronic activation of mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) are well-characterized promoters of aging and age-associated degenerative pathologies. Sestrins, a family of highly conserved stress-inducible proteins, are important negative regulators of both ROS and mTORC1 signaling pathways; however, the mechanistic basis of how Sestrins suppress these pathways remains elusive. In the past couple of years, breakthrough discoveries about Sestrin signaling and its molecular nature have markedly increased our biochemical understanding of Sestrin function. These discoveries have also uncovered new potential therapeutic strategies that may eventually enable us to attenuate aging and age-associated diseases.

  14. Molecular basis of ancestral vertebrate electroreception.

    PubMed

    Bellono, Nicholas W; Leitch, Duncan B; Julius, David

    2017-03-16

    Elasmobranch fishes, including sharks, rays, and skates, use specialized electrosensory organs called ampullae of Lorenzini to detect extremely small changes in environmental electric fields. Electrosensory cells within these ampullae can discriminate and respond to minute changes in environmental voltage gradients through an unknown mechanism. Here we show that the voltage-gated calcium channel CaV1.3 and the big conductance calcium-activated potassium (BK) channel are preferentially expressed by electrosensory cells in little skate (Leucoraja erinacea) and functionally couple to mediate electrosensory cell membrane voltage oscillations, which are important for the detection of specific, weak electrical signals. Both channels exhibit unique properties compared with their mammalian orthologues that support electrosensory functions: structural adaptations in CaV1.3 mediate a low-voltage threshold for activation, and alterations in BK support specifically tuned voltage oscillations. These findings reveal a molecular basis of electroreception and demonstrate how discrete evolutionary changes in ion channel structure facilitate sensory adaptation.

  15. Structural basis of enzymatic benzene ring reduction.

    PubMed

    Weinert, Tobias; Huwiler, Simona G; Kung, Johannes W; Weidenweber, Sina; Hellwig, Petra; Stärk, Hans-Joachim; Biskup, Till; Weber, Stefan; Cotelesage, Julien J H; George, Graham N; Ermler, Ulrich; Boll, Matthias

    2015-08-01

    In chemical synthesis, the widely used Birch reduction of aromatic compounds to cyclic dienes requires alkali metals in ammonia as extremely low-potential electron donors. An analogous reaction is catalyzed by benzoyl-coenzyme A reductases (BCRs) that have a key role in the globally important bacterial degradation of aromatic compounds at anoxic sites. Because of the lack of structural information, the catalytic mechanism of enzymatic benzene ring reduction remained obscure. Here, we present the structural characterization of a dearomatizing BCR containing an unprecedented tungsten cofactor that transfers electrons to the benzene ring in an aprotic cavity. Substrate binding induces proton transfer from the bulk solvent to the active site by expelling a Zn(2+) that is crucial for active site encapsulation. Our results shed light on the structural basis of an electron transfer process at the negative redox potential limit in biology. They open the door for biological or biomimetic alternatives to a basic chemical synthetic tool.

  16. Conformal basis for flat space amplitudes

    NASA Astrophysics Data System (ADS)

    Pasterski, Sabrina; Shao, Shu-Heng

    2017-09-01

    We study solutions of the Klein-Gordon, Maxwell, and linearized Einstein equations in R1 ,d +1 that transform as d -dimensional conformal primaries under the Lorentz group S O (1 ,d +1 ). Such solutions, called conformal primary wavefunctions, are labeled by a conformal dimension Δ and a point in Rd, rather than an on-shell (d +2 )-dimensional momentum. We show that the continuum of scalar conformal primary wavefunctions on the principal continuous series Δ ∈d/2 +i R of S O (1 ,d +1 ) spans a complete set of normalizable solutions to the wave equation. In the massless case, with or without spin, the transition from momentum space to conformal primary wavefunctions is implemented by a Mellin transform. As a consequence of this construction, scattering amplitudes in this basis transform covariantly under S O (1 ,d +1 ) as d -dimensional conformal correlators.

  17. The Immunological Basis of Inflammatory Bowel Disease

    PubMed Central

    Silva, Francesca A. R.; Rodrigues, Bruno L.; Ayrizono, Maria de Lourdes S.

    2016-01-01

    Inflammatory bowel diseases (IBDs) are chronic ailments, Crohn's disease and ulcerative colitis being the most important. These diseases present an inflammatory profile and they differ according to pathophysiology, the affected area in the gastrointestinal tract, and the depth of the inflammation in the intestinal wall. The immune characteristics of IBD arise from abnormal responses of the innate and adaptive immune system. The number of Th17 cells increases in the peripheral blood of IBD patients, while Treg cells decrease, suggesting that the Th17/Treg proportion plays an important role in the development and maintenance of inflammation. The purpose of this review was to determine the current state of knowledge on the immunological basis of IBD. Many studies have shown the need for further explanation of the development and maintenance of the inflammatory process. PMID:28070181

  18. Structural basis for reversible photoswitching in Dronpa.

    PubMed

    Andresen, Martin; Stiel, Andre C; Trowitzsch, Simon; Weber, Gert; Eggeling, Christian; Wahl, Markus C; Hell, Stefan W; Jakobs, Stefan

    2007-08-07

    Dronpa is a novel GFP-like fluorescent protein with exceptional light-controlled switching properties. It may be reversibly switched between a fluorescent on-state and a nonfluorescent off-state by irradiation with light. To elucidate the molecular basis of the switching mechanism, we generated reversibly switchable Dronpa protein crystals. Using these crystals we determined the elusive dark-state structure of Dronpa at 1.95-A resolution. We found that the photoswitching results in a cis-trans isomerization of the chromophore accompanied by complex structural rearrangements of four nearby amino acid residues. Because of this cascade of intramolecular events, the chromophore is exposed to distinct electrostatic surface potentials, which are likely to influence the protonation equilibria at the chromophore. We suggest a comprehensive model for the light-induced switching mechanism, connecting a cascade of structural rearrangements with different protonation states of the chromophore.

  19. An empirical basis for Mach bands

    PubMed Central

    Lotto, R. Beau; Williams, S. Mark; Purves, Dale

    1999-01-01

    Mach bands, the illusory brightness maxima and minima perceived at the initiation and termination of luminance gradients, respectively, are generally considered a direct perceptual manifestation of lateral inhibitory interactions among retinal or other lower order visual neurons. Here we examine an alternative explanation, namely that Mach bands arise as a consequence of real-world luminance gradients. In this first of two companion papers, we analyze the natural sources of luminance gradients, demonstrating that real-world gradients arising from curved surfaces are ordinarily adorned by photometric highlights and lowlights in the position of the illusory bands. The prevalence of such gradients provides an empirical basis for the generation of this perceptual phenomenon. PMID:10220450

  20. Configuration management after design basis reconstitution

    SciTech Connect

    Purcell, J.J. ); Livingston, B.R. )

    1991-01-01

    Over the last few years, Fort Calhoun station (FCS) has implemented a number of programs to enhance plant operability and readiness. The design basis document (DBD) reconstitution project was the cornerstone of this effort. Vendor manual upgrade, operating procedures upgrade, plant equipment data-base verification, equipment labeling, and warehousing improvements were also implemented as part of this improvement program. With the completion of these programs, plant documentation was current to the baselines established by each program, and a configuration management program (CMP) was established to maintain this level of accuracy throughout the remaining life of FCS. Change control throughout the organization has been reviewed and upgraded to ensure that all changes are evaluated for impact to the design bases.

  1. Quantum Fourier transform in computational basis

    NASA Astrophysics Data System (ADS)

    Zhou, S. S.; Loke, T.; Izaac, J. A.; Wang, J. B.

    2017-03-01

    The quantum Fourier transform, with exponential speed-up compared to the classical fast Fourier transform, has played an important role in quantum computation as a vital part of many quantum algorithms (most prominently, Shor's factoring algorithm). However, situations arise where it is not sufficient to encode the Fourier coefficients within the quantum amplitudes, for example in the implementation of control operations that depend on Fourier coefficients. In this paper, we detail a new quantum scheme to encode Fourier coefficients in the computational basis, with fidelity 1 - δ and digit accuracy ɛ for each Fourier coefficient. Its time complexity depends polynomially on log (N), where N is the problem size, and linearly on 1/δ and 1/ɛ . We also discuss an application of potential practical importance, namely the simulation of circulant Hamiltonians.

  2. Molecular basis of human cerebral malaria development.

    PubMed

    Wah, Saw Thu; Hananantachai, Hathairad; Kerdpin, Usanee; Plabplueng, Chotiros; Prachayasittikul, Virapong; Nuchnoi, Pornlada

    2016-01-01

    Cerebral malaria is still a deleterious health problem in tropical countries. The wide spread of malarial drug resistance and the lack of an effective vaccine are obstacles for disease management and prevention. Parasite and human genetic factors play important roles in malaria susceptibility and disease severity. The malaria parasite exerted a potent selective signature on the human genome, which is apparent in the genetic polymorphism landscape of genes related to pathogenesis. Currently, much genomic data and a novel body of knowledge, including the identification of microRNAs, are being increasingly accumulated for the development of laboratory testing cassettes for cerebral malaria prevention. Therefore, understanding of the underlying complex molecular basis of cerebral malaria is important for the design of strategy for cerebral malaria treatment and control.

  3. Physiologic basis for understanding quantitative dehydration assessment.

    PubMed

    Cheuvront, Samuel N; Kenefick, Robert W; Charkoudian, Nisha; Sawka, Michael N

    2013-03-01

    Dehydration (body water deficit) is a physiologic state that can have profound implications for human health and performance. Unfortunately, dehydration can be difficult to assess, and there is no single, universal gold standard for decision making. In this article, we review the physiologic basis for understanding quantitative dehydration assessment. We highlight how phenomenologic interpretations of dehydration depend critically on the type (dehydration compared with volume depletion) and magnitude (moderate compared with severe) of dehydration, which in turn influence the osmotic (plasma osmolality) and blood volume-dependent compensatory thresholds for antidiuretic and thirst responses. In particular, we review new findings regarding the biological variation in osmotic responses to dehydration and discuss how this variation can help provide a quantitative and clinically relevant link between the physiology and phenomenology of dehydration. Practical measures with empirical thresholds are provided as a starting point for improving the practice of dehydration assessment.

  4. The molecular basis of inherited afibrinogenaemia.

    PubMed

    Neerman-Arbez, M

    2001-07-01

    This article reviews the substantial progress made in understanding the molecular basis of inherited afibrinogenaemia (or congenital afibrinogenaemia), an autosomal recessive disorder characterised by the complete absence of detectable fibrinogen. The identification in 1999 of the first genetic defect, recurrent homozygous deletions of approximately 11 kb of the fibrinogen alpha-chain (FGA) gene, revealed that the disease was caused by defective fibrinogen synthesis, and led to the subsequent analysis of the three fibrinogen genes in other affected individuals with the identification of numerous causative mutations. Combined analyses of more than thirty unrelated afibrinogenaemia families from various ethnic groups have shown that the majority of patients have truncating mutations in the FGA gene although intuitively all three fibrinogen genes might be equally implicated. These results will facilitate molecular diagnosis of the disorder, permit prenatal diagnosis for families who so desire, and pave the way for new therapeutic approaches such as gene therapy.

  5. The molecular basis of peanut allergy.

    PubMed

    Mueller, Geoffrey A; Maleki, Soheila J; Pedersen, Lars C

    2014-05-01

    Peanut allergens can trigger a potent and sometimes dangerous immune response in an increasing number of people. The molecular structures of these allergens form the basis for understanding this response. This review describes the currently known peanut allergen structures and discusses how modifications both enzymatic and non-enzymatic affect digestion, innate immune recognition, and IgE interactions. The allergen structures help explain cross-reactivity among allergens from different sources, which is useful in improving patient diagnostics. Surprisingly, it was recently noted that similar short peptide sequences among unrelated peanut allergens could also be a source of cross-reactivity. The molecular features of peanut allergens continue to inform predictions and provide new research directions in the study of allergic disease.

  6. A neural basis for social cooperation.

    PubMed

    Rilling, James; Gutman, David; Zeh, Thorsten; Pagnoni, Giuseppe; Berns, Gregory; Kilts, Clinton

    2002-07-18

    Cooperation based on reciprocal altruism has evolved in only a small number of species, yet it constitutes the core behavioral principle of human social life. The iterated Prisoner's Dilemma Game has been used to model this form of cooperation. We used fMRI to scan 36 women as they played an iterated Prisoner's Dilemma Game with another woman to investigate the neurobiological basis of cooperative social behavior. Mutual cooperation was associated with consistent activation in brain areas that have been linked with reward processing: nucleus accumbens, the caudate nucleus, ventromedial frontal/orbitofrontal cortex, and rostral anterior cingulate cortex. We propose that activation of this neural network positively reinforces reciprocal altruism, thereby motivating subjects to resist the temptation to selfishly accept but not reciprocate favors.

  7. Physiological basis for residual feed intake.

    PubMed

    Herd, R M; Arthur, P F

    2009-04-01

    Residual feed intake (RFI) is a measure of feed efficiency that is independent of level of production, such as size and growth rate in beef cattle, and thus is a useful new trait for studying the physiological mechanisms underlying variation in feed efficiency. Five major physiological processes are likely to contribute to variation in RFI, these being processes associated with intake of feed, digestion of feed, metabolism (anabolism and catabolism associated with and including variation in body composition), physical activity, and thermoregulation. Studies on Angus steers following divergent selection for RFI estimated that heat production from metabolic processes, body composition, and physical activity explained 73% of the variation in RFI. The proportions of variation in RFI that these processes explain are protein turnover, tissue metabolism and stress (37%); digestibility (10%); heat increment and fermentation (9%); physical activity (9%); body composition (5%); and feeding patterns (2%). Other studies in cattle and studies in poultry similarly found these processes to be important in explaining RFI. The physiological mechanisms identified so far are based on very few studies, some of which have small sample sizes. The genomic basis to variation in these physiological processes remains to be determined. Early studies have shown many hundred genes to be associated with differences in RFI, perhaps in hindsight not surprising given the diversity of physiological processes involved. Further research is required to better understand the mechanisms responsible for the variation in RFI in target populations and to marry the physiological information with molecular genetics information that will become the basis for commercial tests for genetically superior animals.

  8. The neural basis of human tool use.

    PubMed

    Orban, Guy A; Caruana, Fausto

    2014-01-01

    In this review, we propose that the neural basis for the spontaneous, diversified human tool use is an area devoted to the execution and observation of tool actions, located in the left anterior supramarginal gyrus (aSMG). The aSMG activation elicited by observing tool use is typical of human subjects, as macaques show no similar activation, even after an extensive training to use tools. The execution of tool actions, as well as their observation, requires the convergence upon aSMG of inputs from different parts of the dorsal and ventral visual streams. Non-semantic features of the target object may be provided by the posterior parietal cortex (PPC) for tool-object interaction, paralleling the well-known PPC input to anterior intraparietal (AIP) for hand-object interaction. Semantic information regarding tool identity, and knowledge of the typical manner of handling the tool, could be provided by inferior and middle regions of the temporal lobe. Somatosensory feedback and technical reasoning, as well as motor and intentional constraints also play roles during the planning of tool actions and consequently their signals likewise converge upon aSMG. We further propose that aSMG may have arisen though duplication of monkey AIP and invasion of the duplicate area by afferents from PPC providing distinct signals depending on the kinematics of the manipulative action. This duplication may have occurred when Homo Habilis or Homo Erectus emerged, generating the Oldowan or Acheulean Industrial complexes respectively. Hence tool use may have emerged during hominid evolution between bipedalism and language. We conclude that humans have two parietal systems involved in tool behavior: a biological circuit for grasping objects, including tools, and an artifactual system devoted specifically to tool use. Only the latter allows humans to understand the causal relationship between tool use and obtaining the goal, and is likely to be the basis of all technological developments.

  9. Molecular Basis of KELnull Phenotype in Brazilians

    PubMed Central

    Boturão-Neto, Edmir; Yamamoto, Mihoko; Chiba, Akemi Kuroda; Kimura, Elisa Yuriko Sugano; de Oliveira, Maria do Carmo Valgueiro Costa; do Monte Barretto, Cláudia Lumack; Nunes, Mércia Maria Alves; Albuquerque, Sérgio Roberto Lopes; de Deus Santos, Marcos Daniel; Bordin, José Orlando

    2015-01-01

    Summary Background KELnull (K0) persons can produce clinically significant anti-KEL5 antibody after transfusion and/or pregnancy, requiring K0 blood transfusion when indicated. 37 K0 alleles have been reported in studies over different populations, but none in Amerindian-Caucasian descendants from South America. The aim of this study was to identify the molecular basis of K0 phenotype in Brazilians. Methods We investigated three K0 samples from different Brazilian blood banks (Recife, Manaus, and Vila Velha) in women with anti-KEL5. KEL antigen typing was performed by serologic techniques, and the K0 status was confirmed by flow cytometry. PCR-RFLP and DNA sequencing of the KEL coding and exon-intron regions were also performed. Results RBCs of the 3 patients were phenotyped as KEL:-1,−2,−3,−4,−7. The 3 patients had the same KEL*02/02 genotype and were negative for KEL*02.03 and KEL*02.06 alleles. The Recife K0 patient was homozygous for IVS16 + 1g>a mutation (KEL*02N.31 allele). The flow cytometry with anti-KEL1, anti-KEL2, anti-KEL3, anti-KEL4, and anti-CD238 confirmed the K0 phenotype. In addition, we found the c.10423C>T mutation (KEL*02N.04 allele) in both the Manaus K0 and the Vila Velha K0 patients. Conclusion This report represents the first study of K0 molecular basis performed in Amerindian-Caucasian descendants from South America. PMID:25960716

  10. PREFACE: Progress in the ITER Physics Basis

    NASA Astrophysics Data System (ADS)

    Ikeda, K.

    2007-06-01

    I would firstly like to congratulate all who have contributed to the preparation of the `Progress in the ITER Physics Basis' (PIPB) on its publication and express my deep appreciation of the hard work and commitment of the many scientists involved. With the signing of the ITER Joint Implementing Agreement in November 2006, the ITER Members have now established the framework for construction of the project, and the ITER Organization has begun work at Cadarache. The review of recent progress in the physics basis for burning plasma experiments encompassed by the PIPB will be a valuable resource for the project and, in particular, for the current Design Review. The ITER design has been derived from a physics basis developed through experimental, modelling and theoretical work on the properties of tokamak plasmas and, in particular, on studies of burning plasma physics. The `ITER Physics Basis' (IPB), published in 1999, has been the reference for the projection methodologies for the design of ITER, but the IPB also highlighted several key issues which needed to be resolved to provide a robust basis for ITER operation. In the intervening period scientists of the ITER Participant Teams have addressed these issues intensively. The International Tokamak Physics Activity (ITPA) has provided an excellent forum for scientists involved in these studies, focusing their work on the high priority physics issues for ITER. Significant progress has been made in many of the issues identified in the IPB and this progress is discussed in depth in the PIPB. In this respect, the publication of the PIPB symbolizes the strong interest and enthusiasm of the plasma physics community for the success of the ITER project, which we all recognize as one of the great scientific challenges of the 21st century. I wish to emphasize my appreciation of the work of the ITPA Coordinating Committee members, who are listed below. Their support and encouragement for the preparation of the PIPB were

  11. 75 FR 64071 - Basis Reporting by Securities Brokers and Basis Determination for Stock

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-18

    ... provided to the taxpayer within a reasonable time after the sale or transfer. iii. Application of FIFO Rule... are the earliest acquired shares (FIFO rule). A commentator suggested that the final regulations clarify that the FIFO rule applies on an account by account basis. The account by account rule in...

  12. Reduced Order Model Basis Vector Generation: Generates Basis Vectors fro ROMs

    SciTech Connect

    Arrighi, Bill

    2016-03-03

    libROM is a library that implements order reduction via singular value decomposition (SVD) of sampled state vectors. It implements 2 parallel, incremental SVD algorithms and one serial, non-incremental algorithm. It also provides a mechanism for adaptive sampling of basis vectors.

  13. The anatomic basis of parathyroid surgery.

    PubMed

    Wang, C

    1976-03-01

    A study of 645 normal adult parathyroid glands in 160 cadavers revealed that there is a definite pattern of anatomic distribution on the basis of the embryologic development of the parathyroid, thyroid, and thymic glands. The sites of predilection of the upper gland (Parathyroid IV) are, in order of frequency, the cricothyroid junction; the dorsum of the upper pole of the thyroid; and the retropharyngeal space. Those of the lower gland (Parathyroid III) are at the lower pole of the thyroid and the thymic tongue; rarely in the upper, the lateral neck, or the mediastinum. An understanding of the developmental relationship of the parathyroid glands to the thyroid and the thymus is fundamental in the delineation of the embryologic origin of the parathyroid glands. The parathyroid gland, located within the surgical capsule of the thyroid (subcapsular), when diseased, remains in place locally. A gland outside of the capsule (extracapsular) is often displaced into the posterior or anterior mediastinum. A collective assessment of the size, weight, color, shape, and consistency of the parathyroid gland is mandatory in the determination of its normalcy. Frozen section examination for stromal and intracellular fatty content is an added assurance of normalcy. That parathyroid glands sink in saline solution, and fat globules float, may aid in differentiating the two types of tissue. Supernumerary, fused, and intrathyroidal parathyroids, albeit rare, are of surgical importance.

  14. Cellular and Molecular Basis of Liver Development

    PubMed Central

    Shin, Donghun; Singh Monga, Satdarshan Pal

    2015-01-01

    Liver is a prime organ responsible for synthesis, metabolism, and detoxification. The organ is endodermal in origin and its development is regulated by temporal, complex, and finely balanced cellular and molecular interactions that dictate its origin, growth, and maturation. We discuss the relevance of endoderm patterning, which truly is the first step toward mapping of domains that will give rise to specific organs. Once foregut patterning is completed, certain cells within the foregut endoderm gain competence in the form of expression of certain transcription factors that allow them to respond to certain inductive signals. Hepatic specification is then a result of such inductive signals, which often emanate from the surrounding mesenchyme. During hepatic specification bipotential hepatic stem cells or hepatoblasts become apparent and undergo expansion, which results in a visible liver primordium during the stage of hepatic morphogenesis. Hepatoblasts next differentiate into either hepatocytes or cholangiocytes. The expansion and differentiation is regulated by cellular and molecular interactions between hepatoblasts and mesenchymal cells including sinusoidal endothelial cells, stellate cells, and also innate hematopoietic elements. Further maturation of hepatocytes and cholangiocytes continues during late hepatic development as a function of various growth factors. At this time, liver gains architectural novelty in the form of zonality and at cellular level acquires polarity. A comprehensive elucidation of such finely tuned developmental cues have been the basis of transdifferentiation of various types of stem cells to hepatocyte-like cells for purposes of understanding health and disease and for therapeutic applications. PMID:23720330

  15. Electromagnetic Basis of Metabolism and Heredity

    NASA Technical Reports Server (NTRS)

    Freund, Friedemann; Stolc, Viktor

    2016-01-01

    Living organisms control their cellular biological clocks to maintain functional oscillation of the redox cycle, also called the "metabolic cycle" or "respiratory cycle". Organization of cellular processes requires parallel processing on a synchronized time-base. These clocks coordinate the timing of all biochemical processes in the cell, including energy production, DNA replication, and RNA transcription. When this universal time keeping function is perturbed by exogenous induction of reactive oxygen species (ROS), the rate of metabolism changes. This causes oxidative stress, aging and mutations. Therefore, good temporal coordination of the redox cycle not only actively prevents chemical conflict between the reductive and oxidative partial reactions; it also maintains genome integrity and lifespan. Moreover, this universal biochemical rhythm can be disrupted by ROS induction in vivo. This in turn can be achieved by blocking the electron transport chain either endogenously or exogenously by various metabolites, e.g. hydrogen sulfide (H2S), highly diffusible drugs, and carbon monoxide (CO). Alternatively, the electron transport in vivo can be attenuated via a coherent or interfering transfer of energy from exogenous ultralow frequency (ULF) and extremely low frequency (ELF) electromagnetic (EM) fields, suggesting that-on Earth-such ambient fields are an omnipresent (and probably crucially important) factor for the time-setting basis of universal biochemical reactions in living cells. Our work demonstrated previously un-described evidence for quantum effects in biology by electromagnetic coupling below thermal noise at the universal electron transport chain (ETC) in vivo.

  16. The Neural Basis of Following Advice

    PubMed Central

    Biele, Guido; Rieskamp, Jörg; Krugel, Lea K.; Heekeren, Hauke R.

    2011-01-01

    Learning by following explicit advice is fundamental for human cultural evolution, yet the neurobiology of adaptive social learning is largely unknown. Here, we used simulations to analyze the adaptive value of social learning mechanisms, computational modeling of behavioral data to describe cognitive mechanisms involved in social learning, and model-based functional magnetic resonance imaging (fMRI) to identify the neurobiological basis of following advice. One-time advice received before learning had a sustained influence on people's learning processes. This was best explained by social learning mechanisms implementing a more positive evaluation of the outcomes from recommended options. Computer simulations showed that this “outcome-bonus” accumulates more rewards than an alternative mechanism implementing higher initial reward expectation for recommended options. fMRI results revealed a neural outcome-bonus signal in the septal area and the left caudate. This neural signal coded rewards in the absence of advice, and crucially, it signaled greater positive rewards for positive and negative feedback after recommended rather than after non-recommended choices. Hence, our results indicate that following advice is intrinsically rewarding. A positive correlation between the model's outcome-bonus parameter and amygdala activity after positive feedback directly relates the computational model to brain activity. These results advance the understanding of social learning by providing a neurobiological account for adaptive learning from advice. PMID:21713027

  17. Structural basis for spectrin recognition by ankyrin

    SciTech Connect

    Ipsaro, Jonathan J.; Mondragón, Alfonso

    2010-10-19

    Maintenance of membrane integrity and organization in the metazoan cell is accomplished through intracellular tethering of membrane proteins to an extensive, flexible protein network. Spectrin, the principal component of this network, is anchored to membrane proteins through the adaptor protein ankyrin. To elucidate the atomic basis for this interaction, we determined a crystal structure of human {beta}I-spectrin repeats 13 to 15 in complex with the ZU5-ANK domain of human ankyrin R. The structure reveals the role of repeats 14 to 15 in binding, the electrostatic and hydrophobic contributions along the interface, and the necessity for a particular orientation of the spectrin repeats. Using structural and biochemical data as a guide, we characterized the individual proteins and their interactions by binding and thermal stability analyses. In addition to validating the structural model, these data provide insight into the nature of some mutations associated with cell morphology defects, including those found in human diseases such as hereditary spherocytosis and elliptocytosis. Finally, analysis of the ZU5 domain suggests it is a versatile protein-protein interaction module with distinct interaction surfaces. The structure represents not only the first of a spectrin fragment in complex with its binding partner, but also that of an intermolecular complex involving a ZU5 domain.

  18. The genetic basis of chronic mountain sickness.

    PubMed

    Ronen, Roy; Zhou, Dan; Bafna, Vineet; Haddad, Gabriel G

    2014-11-01

    Chronic mountain sickness (CMS) is a disease that affects many high-altitude dwellers, particularly in the Andean Mountains in South America. The hallmark symptom of CMS is polycythemia, which causes increased risk of pulmonary hypertension and stroke (among other symptoms). A prevailing hypothesis in high-altitude medicine is that CMS results from a population-specific "maladaptation" to the hypoxic conditions at high altitude. In contrast, the prevalence of CMS is very low in other high-altitude populations (e.g., Tibetans and Ethiopians), which are seemingly well adapted to hypoxia. In recent years, concurrent with the advent of genomic technologies, several studies have investigated the genetic basis of adaptation to altitude. These studies have identified several candidate genes that may underlie the adaptation, or maladaptation. Interestingly, some of these genes are targeted by known drugs, raising the possibility of new treatments for CMS and other ischemic diseases. We review recent discoveries, alongside the methodologies used to obtain them, and outline some of the challenges remaining in the field. ©2014 Int. Union Physiol. Sci./Am. Physiol. Soc.

  19. Molecular Basis of Laminin-Integrin Interactions.

    PubMed

    Yamada, Masashi; Sekiguchi, Kiyotoshi

    2015-01-01

    Laminins are composed of three polypeptide chains, designated as α, β, and γ. The C-terminal region of laminin heterotrimers, containing coiled-coil regions, short tails, and laminin globular (LG) domains, is necessary and sufficient for binding to integrins, which are the major laminin receptor class. Laminin recognition by integrins critically requires the α chain LG domains and a glutamic acid residue of the γ chain at the third position from the C-terminus. Furthermore, the C-terminal region of the β chain contains a short amino acid sequence that modulates laminin affinity for integrins. Thus, all three of the laminin chains act cooperatively to facilitate integrin binding. Mammals possess 5 α (α1-5), 3 β (β1-3), and 3 γ (γ1-3) chains, combinations of which give rise to 16 distinct laminin isoforms. Each isoform is expressed in a tissue-specific and developmental stage-specific manner, exerting its functions through binding of integrins. In this review, we detail the current knowledge surrounding the molecular basis and physiological relevance of specific interactions between laminins and integrins, and describe the mechanisms underlying laminin action through integrins.

  20. Genetic and Developmental Basis of Cardiovascular Malformations

    PubMed Central

    Azhar, Mohamad; Ware, Stephanie M.

    2015-01-01

    Cardiovascular malformations (CVMs) are the most common birth defect, occurring in 1–5% of all live births. Genetic, epigenetic, and environmental factors all influence the development of CVMs, and an improved understanding of causation of CVMs is a prerequisite for prevention. Cardiac development is a complex, multi-step process of morphogenesis that is under genetic regulation. Multiple developmental pathways act independently or in combination to effect proper cardiac lineage specification, differentiation, and structure. Because of this complexity, there are numerous potential mechanisms by which genetic variation can impact both fetal cardiac development and latent cardiac disease. Although the genetic contribution to CVMs is well recognized, the genetic causes of human CVMs are still identified relatively infrequently. Mouse models are important tools to investigate the molecular mechanisms underpinning cardiac development as well as the complex genetics that characterize human CVMs. In this review we provide an overview of the key genetic concepts characterizing human CVMs, review their developmental basis, and provide examples to illustrate the critical developmental and genetic concepts underlying the pathogenesis of CVMs. PMID:26876120

  1. Physicochemical and physiological basis of dichromatic colour

    NASA Astrophysics Data System (ADS)

    Kreft, Samo; Kreft, Marko

    2007-11-01

    Out of three perceptual characteristics of the colour of any substance, the hue depends mostly on the spectral properties of a substance, while the brightness and saturation depend also on the concentration of a substance and its thickness. Here, we report that evident change of the hue of the colour (i.e., from green to red) is due to a change in concentration or the thickness of a layer in some exceptional substances such as pumpkin seed oil or an aqueous solution of bromophenol blue. In some regions of Central Europe, salad dressing is made preferably with the pumpkin seed oil, which has a strong characteristic nut-like taste and remarkable properties of the colour: it appears red in a bottle, but green when served as a salad dressing. The colour of the pumpkin seed oil was previously described as brownish yellow, dark green, dark green to red ochre or dark reddish brown to light yellow green. We elucidated the physicochemical and physiological basis of such dichromatism by Beer-Lambert law and by the characteristics of human colour perception. Our concept was corroborated by the outcome of calculations of colour from spectral properties using colour matching functions. We found that dichromatism is observed if the absorption spectrum of any substance has at least two local minima: one wide but shallow and one narrow but deep local minimum.

  2. Toward a Neural Basis for Social Behavior

    PubMed Central

    Stanley, Damian A.; Adolphs, Ralph

    2014-01-01

    Nearly 25 years ago, the shared interests of psychologists and biologists in understanding the neural basis of social behavior led to the inception of social neuroscience. In the past decade, this field has exploded, in large part due to the infusion of studies that use fMRI. At the same time, tensions have arisen about how to prioritize a diverse range of questions and about the authority of neurobiological data in answering them. The field is now poised to tackle some of the most interesting and important questions about human and animal behavior but at the same time faces uncertainty about how to achieve focus in its research and cohesion among the scientists who tackle it. The next 25 years offer the opportunity to alleviate some of these growing pains, as well as the challenge of answering large questions that encompass the nature and bounds of diverse social interactions (in humans, including interactions through the internet); how to characterize, and treat, social dysfunction in psychiatric illness; and how to compare social cognition in humans with that in other animals. PMID:24183030

  3. The genetic basis of obesity complications.

    PubMed

    Skrypnik, Katarzyna; Suliburska, Joanna; Skrypnik, Damian; Pilarski, Łukasz; Reguła, Julita; Bogdański, Paweł

    2017-01-01

    Intensive research is currently being performed into the genetic background of excess body mass compli- cations such as diabetes, cardiovascular disorders, especially atherosclerosis and coronary heart disease. Chronic inflammation is an important process in the pathogenesis of obesity, wherein there is an aberrant ex- pression of genes encoding adipokines. Visceral tissue is characterized by a higher expression and secretion of interleukin-8, interleukin-1ß and plasminogen activator inhibitor 1 in the subcutaneous tissue secretion of leptin prevails. An important complication of obesity is obstructive sleep apnea, often observed in Prader- Willi syndrome. The genetic background of sleep apnea may be a polymorphism of the SREBF1 gene. The consequence of excess body mass is metabolic syndrome, which may be related to the occurrence of the rs926198 variant of gene encoding caveolin-1. The genes of transcription factor TCF7L2 and PPAR-γ2 take part in the pathogenesis of diabetes development. It has been demonstrated that oncogenes FOS, FOSB, and JUN may be co-responsible not only for obesity but also for osteoporosis and colorectal cancer. It has been shown that weight loss causes a modification in the expression of about 100 genes involvedt in the production of substances such as cytokines and other responsible for chronic inflammation in obesity. In future studies on the complications of obesity, such scientific disciplines as proteomics, peptidomics, metabolomics and transcriptomics should be used. The aim of this study is to present the current state of knowledge about the genetic basis of obesity complications.

  4. A brain basis for musical hallucinations☆

    PubMed Central

    Kumar, Sukhbinder; Sedley, William; Barnes, Gareth R.; Teki, Sundeep; Friston, Karl J.; Griffiths, Timothy D.

    2014-01-01

    The physiological basis for musical hallucinations (MH) is not understood. One obstacle to understanding has been the lack of a method to manipulate the intensity of hallucination during the course of experiment. Residual inhibition, transient suppression of a phantom percept after the offset of a masking stimulus, has been used in the study of tinnitus. We report here a human subject whose MH were residually inhibited by short periods of music. Magnetoencephalography (MEG) allowed us to examine variation in the underlying oscillatory brain activity in different states. Source-space analysis capable of single-subject inference defined left-lateralised power increases, associated with stronger hallucinations, in the gamma band in left anterior superior temporal gyrus, and in the beta band in motor cortex and posteromedial cortex. The data indicate that these areas form a crucial network in the generation of MH, and are consistent with a model in which MH are generated by persistent reciprocal communication in a predictive coding hierarchy. PMID:24445167

  5. The neural basis of the imitation drive

    PubMed Central

    Sugiura, Motoaki; Nozawa, Takayuki; Kotozaki, Yuka; Yomogida, Yukihito; Ihara, Mizuki; Akimoto, Yoritaka; Thyreau, Benjamin; Izumi, Shinichi; Kawashima, Ryuta

    2016-01-01

    Spontaneous imitation is assumed to underlie the acquisition of important skills by infants, including language and social interaction. In this study, functional magnetic resonance imaging (fMRI) was used to examine the neural basis of ‘spontaneously’ driven imitation, which has not yet been fully investigated. Healthy participants were presented with movie clips of meaningless bimanual actions and instructed to observe and imitate them during an fMRI scan. The participants were subsequently shown the movie clips again and asked to evaluate the strength of their ‘urge to imitate’ (Urge) for each action. We searched for cortical areas where the degree of activation positively correlated with Urge scores; significant positive correlations were observed in the right supplementary motor area (SMA) and bilateral midcingulate cortex (MCC) under the imitation condition. These areas were not explained by explicit reasons for imitation or the kinematic characteristics of the actions. Previous studies performed in monkeys and humans have implicated the SMA and MCC/caudal cingulate zone in voluntary actions. This study also confirmed the functional connectivity between Urge and imitation performance using a psychophysiological interaction analysis. Thus, our findings reveal the critical neural components that underlie spontaneous imitation and provide possible reasons why infants imitate spontaneously. PMID:26168793

  6. The Perceptual Basis of Vast Space.

    PubMed

    Klatzky, Roberta L; Thompson, William B; Stefanucci, Jeanine K; Gill, Devin; McGee, D Kevin

    2017-03-20

    "Vast" is a word often applied to environmental terrain that is perceived to have large spatial extent. This judgment is made even at viewing distances where traditional metric depth cues are not useful. This paper explores the perceptual basis of vast experience, including reliability and visual precursors. Experiment 1 demonstrated strong agreement in ratings of the spatial extent of two-dimensional (2D) scene images by participants in two countries under very different viewing conditions. Image categories labeled "vast" often exemplified scene attributes of ruggedness and openness (Oliva & Torralba, 2001). Experiment 2 quantitatively assessed whether these properties predict vastness. High vastness ratings were associated with highly open, or moderately open but rugged, scenes. Experiment 3 provided evidence, consistent with theory, that metric distance perception does not directly mediate the observed vastness ratings. The question remains as to how people perceive vast space when information about environmental scale is unavailable from metric depth cues or associated scene properties. We consider possible answers, including contribution from strong cues to relative depth.

  7. The pathological basis for skeletal scintigraphy.

    PubMed

    Galasko, C S

    1975-08-01

    Skeletal scintigraphy, which has now been established as a useful and accurate method of detecting early skeletal metastases and assessing their response to treatment, has been investigated for its pathological basis. Histological examination of several hyndred necropsy specimens, from sixty-eight patients who died from malignant disease, showed a significant increase of osteoid and immature woven bone in the presence of metastatic cancer. Tumour-cell suspensions of the VX2 carcinoma were injected into the medullary cavity or on to the periosteal surface of the ilia or tibiae of New Zealand white rabbits. A combination of bone destruction and new bone formation, similar to the autopsy material, was seen. There were at least two mechanisms for the new bone production. Initially, intramembranous ossification was seen in the fibrous stroma surrounding the tumour. Once the cortex was involved and cortical bone destruction had occurred, large amounts of woven bone resembling fracture callus were laid down. The new bone had a markedly increased avidity for bone-seeking isotopes, indicating why skeletal scintigraphy was useful. A further twenty rabbits, in whose ilia the VX2 carcinoma was growing, were treated by local irradiation. When treatment was successful the tumour was destroyed, the production of new bone ceased, and the lesion lost its increased avidity for bone-seeking isotopes, indicating that skeletal scintigraphy could be used to assess the response of skeletal metastases to therapy.

  8. The neural basis of monitoring goal progress

    PubMed Central

    Benn, Yael; Webb, Thomas L.; Chang, Betty P. I.; Sun, Yu-Hsuan; Wilkinson, Iain D.; Farrow, Tom F. D.

    2014-01-01

    The neural basis of progress monitoring has received relatively little attention compared to other sub-processes that are involved in goal directed behavior such as motor control and response inhibition. Studies of error-monitoring have identified the dorsal anterior cingulate cortex (dACC) as a structure that is sensitive to conflict detection, and triggers corrective action. However, monitoring goal progress involves monitoring correct as well as erroneous events over a period of time. In the present research, 20 healthy participants underwent functional magnetic resonance imagining (fMRI) while playing a game that involved monitoring progress toward either a numerical or a visuo-spatial target. The findings confirmed the role of the dACC in detecting situations in which the current state may conflict with the desired state, but also revealed activations in the frontal and parietal regions, pointing to the involvement of processes such as attention and working memory (WM) in monitoring progress over time. In addition, activation of the cuneus was associated with monitoring progress toward a specific target presented in the visual modality. This is the first time that activation in this region has been linked to higher-order processing of goal-relevant information, rather than low-level anticipation of visual stimuli. Taken together, these findings identify the neural substrates involved in monitoring progress over time, and how these extend beyond activations observed in conflict and error monitoring. PMID:25309380

  9. Molecular basis of ancestral vertebrate electroreception

    PubMed Central

    Bellono, Nicholas W.; Leitch, Duncan B.; Julius, David

    2017-01-01

    Elasmobranch fishes, including sharks, rays, and skates, use specialized electrosensory organs called Ampullae of Lorenzini to detect extremely small changes in environmental electric fields. Electrosensory cells within these ampullae are able to discriminate and respond to minute changes in environmental voltage gradients through an as-yet unknown mechanism. Here we show that the voltage-gated calcium channel CaV1.3 and big conductance calcium-activated potassium (BK) channel are preferentially expressed by electrosensory cells in little skate (Leucoraja erinacea) and functionally couple to mediate electrosensory cell membrane voltage oscillations, which are important in the detection of specific, weak electrical signals. Both channels exhibit unique properties compared with their mammalian orthologues to support electrosensory functions: structural adaptations in CaV1.3 mediate a low voltage threshold for activation, while alterations in BK support specifically tuned voltage oscillations. These findings reveal a molecular basis of electroreception and demonstrate how discrete evolutionary changes in ion channel structure facilitate sensory adaptation. PMID:28264196

  10. Biological Basis For Computer Vision: Some Perspectives

    NASA Astrophysics Data System (ADS)

    Gupta, Madan M.

    1990-03-01

    Using biology as a basis for the development of sensors, devices and computer vision systems is a challenge to systems and vision scientists. It is also a field of promising research for engineering applications. Biological sensory systems, such as vision, touch and hearing, sense different physical phenomena from our environment, yet they possess some common mathematical functions. These mathematical functions are cast into the neural layers which are distributed throughout our sensory regions, sensory information transmission channels and in the cortex, the centre of perception. In this paper, we are concerned with the study of the biological vision system and the emulation of some of its mathematical functions, both retinal and visual cortex, for the development of a robust computer vision system. This field of research is not only intriguing, but offers a great challenge to systems scientists in the development of functional algorithms. These functional algorithms can be generalized for further studies in such fields as signal processing, control systems and image processing. Our studies are heavily dependent on the the use of fuzzy - neural layers and generalized receptive fields. Building blocks of such neural layers and receptive fields may lead to the design of better sensors and better computer vision systems. It is hoped that these studies will lead to the development of better artificial vision systems with various applications to vision prosthesis for the blind, robotic vision, medical imaging, medical sensors, industrial automation, remote sensing, space stations and ocean exploration.

  11. Cellular basis of memory for addiction.

    PubMed

    Nestler, Eric J

    2013-12-01

    DESPITE THE IMPORTANCE OF NUMEROUS PSYCHOSOCIAL FACTORS, AT ITS CORE, DRUG ADDICTION INVOLVES A BIOLOGICAL PROCESS: the ability of repeated exposure to a drug of abuse to induce changes in a vulnerable brain that drive the compulsive seeking and taking of drugs, and loss of control over drug use, that define a state of addiction. Here, we review the types of molecular and cellular adaptations that occur in specific brain regions to mediate addiction-associated behavioral abnormalities. These include alterations in gene expression achieved in part via epigenetic mechanisms, plasticity in the neurophysiological functioning of neurons and synapses, and associated plasticity in neuronal and synaptic morphology mediated in part by altered neurotrophic factor signaling. Each of these types of drug-induced modifications can be viewed as a form of "cellular or molecular memory." Moreover, it is striking that most addiction-related forms of plasticity are very similar to the types of plasticity that have been associated with more classic forms of "behavioral memory," perhaps reflecting the finite repertoire of adaptive mechanisms available to neurons when faced with environmental challenges. Finally, addiction-related molecular and cellular adaptations involve most of the same brain regions that mediate more classic forms of memory, consistent with the view that abnormal memories are important drivers of addiction syndromes. The goal of these studies which aim to explicate the molecular and cellular basis of drug addiction is to eventually develop biologically based diagnostic tests, as well as more effective treatments for addiction disorders.

  12. Structural basis for retroviral integration into nucleosomes.

    PubMed

    Maskell, Daniel P; Renault, Ludovic; Serrao, Erik; Lesbats, Paul; Matadeen, Rishi; Hare, Stephen; Lindemann, Dirk; Engelman, Alan N; Costa, Alessandro; Cherepanov, Peter

    2015-07-16

    Retroviral integration is catalysed by a tetramer of integrase (IN) assembled on viral DNA ends in a stable complex, known as the intasome. How the intasome interfaces with chromosomal DNA, which exists in the form of nucleosomal arrays, is currently unknown. Here we show that the prototype foamy virus (PFV) intasome is proficient at stable capture of nucleosomes as targets for integration. Single-particle cryo-electron microscopy reveals a multivalent intasome-nucleosome interface involving both gyres of nucleosomal DNA and one H2A-H2B heterodimer. While the histone octamer remains intact, the DNA is lifted from the surface of the H2A-H2B heterodimer to allow integration at strongly preferred superhelix location ±3.5 positions. Amino acid substitutions disrupting these contacts impinge on the ability of the intasome to engage nucleosomes in vitro and redistribute viral integration sites on the genomic scale. Our findings elucidate the molecular basis for nucleosome capture by the viral DNA recombination machinery and the underlying nucleosome plasticity that allows integration.

  13. Genetic Basis for Red Coloration in Birds.

    PubMed

    Lopes, Ricardo J; Johnson, James D; Toomey, Matthew B; Ferreira, Mafalda S; Araujo, Pedro M; Melo-Ferreira, José; Andersson, Leif; Hill, Geoffrey E; Corbo, Joseph C; Carneiro, Miguel

    2016-06-06

    The yellow and red feather pigmentation of many bird species [1] plays pivotal roles in social signaling and mate choice [2, 3]. To produce red pigments, birds ingest yellow carotenoids and endogenously convert them into red ketocarotenoids via an oxidation reaction catalyzed by a previously unknown ketolase [4-6]. We investigated the genetic basis for red coloration in birds using whole-genome sequencing of red siskins (Spinus cucullata), common canaries (Serinus canaria), and "red factor" canaries, which are the hybrid product of crossing red siskins with common canaries [7]. We identified two genomic regions introgressed from red siskins into red factor canaries that are required for red coloration. One of these regions contains a gene encoding a cytochrome P450 enzyme, CYP2J19. Transcriptome analysis demonstrates that CYP2J19 is significantly upregulated in the skin and liver of red factor canaries, strongly implicating CYP2J19 as the ketolase that mediates red coloration in birds. Interestingly, a second introgressed region required for red feathers resides within the epidermal differentiation complex, a cluster of genes involved in development of the integument. Lastly, we present evidence that CYP2J19 is involved in ketocarotenoid formation in the retina. The discovery of the carotenoid ketolase has important implications for understanding sensory function and signaling mediated by carotenoid pigmentation.

  14. The anatomic basis of parathyroid surgery.

    PubMed Central

    Wang, C

    1976-01-01

    A study of 645 normal adult parathyroid glands in 160 cadavers revealed that there is a definite pattern of anatomic distribution on the basis of the embryologic development of the parathyroid, thyroid, and thymic glands. The sites of predilection of the upper gland (Parathyroid IV) are, in order of frequency, the cricothyroid junction; the dorsum of the upper pole of the thyroid; and the retropharyngeal space.Those of the lower gland (Parathyroid III) are at the lower pole of the thyroid and the thymic tongue; rarely in the upper, the lateral neck, or the mediastinum. An understanding of the developmental relationship of the parathyroid glands to the thyroid and the thymus is fundamental in the delineation of the embryologic origin of the parathyroid glands. The parathyroid gland, located within the surgical capsule of the thyroid (subcapsular), when diseased, remains in place locally. A gland outside of the capsule (extracapsular) is often displaced into the posterior or anterior mediastinum. A collective assessment of the size, weight, color, shape, and consistency of the parathyroid gland is mandatory in the determination of its normalcy. Frozen section examination for stromal and intracellular fatty content is an added assurance of normalcy. That parathyroid glands sink in saline solution, and fat globules float, may aid in differentiating the two types of tissue. Supernumerary, fused, and intrathyroidal parathyroids, albeit rare, are of surgical importance. PMID:1259483

  15. Inverse problems using reduced basis method

    NASA Astrophysics Data System (ADS)

    Gralla, Phil

    Inverse Problems is a field of great interest for many applications, such as parameter identification and image reconstruction. The underlying models of inverse problems in many applications often involve Partial Differential Equations (PDEs). A Reduced Basis (RB) method for solving PDE based inverse problems is introduced in this thesis. The RB has been rigorously established as an efficient approach for solving PDEs in recent years. In this work, we investigate whether the RB method can be used as a regularization for solving ill-posed and nonlinear inverse problems using iterative methods. We rigorously analyze the RB method and prove convergence of the RB approximation to the exact solution. Furthermore, an iterative algorithm is proposed based on gradient method with RB regularization. We also implement the proposed method numerically and apply the algorithm to the inverse problem of Electrical Impedance Tomography (EIT) which is known to be a notoriously ill-posed and nonlinear. For the EIT example, we provide all necessary details and carefully explain each step of the RB method. We also investigate the limitations of the RB method for solving nonlinear inverse problems in general. We conclude that the RB method can be used to solve nonlinear inverse problems with appropriate assumptions however the assumptions are somewhat restrictive and may not be applicable for a wide range of problems.

  16. The neural basis of tactile motion perception.

    PubMed

    Pei, Yu-Cheng; Bensmaia, Sliman J

    2014-12-15

    The manipulation of objects commonly involves motion between object and skin. In this review, we discuss the neural basis of tactile motion perception and its similarities with its visual counterpart. First, much like in vision, the perception of tactile motion relies on the processing of spatiotemporal patterns of activation across populations of sensory receptors. Second, many neurons in primary somatosensory cortex are highly sensitive to motion direction, and the response properties of these neurons draw strong analogies to those of direction-selective neurons in visual cortex. Third, tactile speed may be encoded in the strength of the response of cutaneous mechanoreceptive afferents and of a subpopulation of speed-sensitive neurons in cortex. However, both afferent and cortical responses are strongly dependent on texture as well, so it is unclear how texture and speed signals are disambiguated. Fourth, motion signals from multiple fingers must often be integrated during the exploration of objects, but the way these signals are combined is complex and remains to be elucidated. Finally, visual and tactile motion perception interact powerfully, an integration process that is likely mediated by visual association cortex.

  17. The neural basis of tactile motion perception

    PubMed Central

    Pei, Yu-Cheng

    2014-01-01

    The manipulation of objects commonly involves motion between object and skin. In this review, we discuss the neural basis of tactile motion perception and its similarities with its visual counterpart. First, much like in vision, the perception of tactile motion relies on the processing of spatiotemporal patterns of activation across populations of sensory receptors. Second, many neurons in primary somatosensory cortex are highly sensitive to motion direction, and the response properties of these neurons draw strong analogies to those of direction-selective neurons in visual cortex. Third, tactile speed may be encoded in the strength of the response of cutaneous mechanoreceptive afferents and of a subpopulation of speed-sensitive neurons in cortex. However, both afferent and cortical responses are strongly dependent on texture as well, so it is unclear how texture and speed signals are disambiguated. Fourth, motion signals from multiple fingers must often be integrated during the exploration of objects, but the way these signals are combined is complex and remains to be elucidated. Finally, visual and tactile motion perception interact powerfully, an integration process that is likely mediated by visual association cortex. PMID:25253479

  18. Scientific basis for the Precautionary Principle

    SciTech Connect

    Vineis, Paolo . E-mail: p.vineis@imperial.ac.uk

    2005-09-01

    The Precautionary Principle is based on two general criteria: (a) appropriate public action should be taken in response to limited, but plausible and credible, evidence of likely and substantial harm; (b) the burden of proof is shifted from demonstrating the presence of risk to demonstrating the absence of risk. Not much has been written about the scientific basis of the precautionary principle, apart from the uncertainty that characterizes epidemiologic research on chronic disease, and the use of surrogate evidence when human evidence cannot be provided. It is proposed in this paper that a new scientific paradigm, based on the theory of evolution, is emerging; this might offer stronger support to the need for precaution in the regulation of environmental risks. Environmental hazards do not consist only in direct attacks to the integrity of DNA or other macromolecules. They can consist in changes that take place already in utero, and that condition disease risks many years later. Also, environmental exposures can act as 'stressors', inducing hypermutability (the mutator phenotype) as an adaptive response. Finally, environmental changes should be evaluated against a background of a not-so-easily modifiable genetic make-up, inherited from a period in which humans were mainly hunters-gatherers and had dietary habits very different from the current ones.

  19. Defining meridians: a modern basis of understanding.

    PubMed

    Longhurst, John C

    2010-06-01

    Acupuncture, one of the primary methods of treatment in traditional Oriental medicine, is based on a system of meridians. Along the meridians lie acupuncture points or acupoints, which are stimulated by needling, pressure or heat to resolve a clinical problem. A number of methods have been used to identify meridians and to explain them anatomically. Thus, tendinomuscular structures, primo-vessels (Bonghan ducts), regions of increased temperature and low skin resistance have been suggested to represent meridians or as methods to identify them. However, none of these methods have met the criteria for a meridian, an entity that, when stimulated by acupuncture can result in clinical improvement. More recently, modern physiologists have put forward the "neural hypothesis" stating that the clinical influence of acupuncture is transmitted primarily through stimulation of sensory nerves that provide signals to the brain, which processes this information and then causes clinical changes associated with treatment. Although additional research is warranted to investigate the role of some of the structures identified, it seems clear that the peripheral and central nervous system can now be considered to be the most rational basis for defining meridians. The meridian maps and associated acupoints located along them are best viewed as road maps that can guide practitioners towards applying acupuncture to achieve optimal clinical results.

  20. The genetic basis of music ability.

    PubMed

    Tan, Yi Ting; McPherson, Gary E; Peretz, Isabelle; Berkovic, Samuel F; Wilson, Sarah J

    2014-01-01

    Music is an integral part of the cultural heritage of all known human societies, with the capacity for music perception and production present in most people. Researchers generally agree that both genetic and environmental factors contribute to the broader realization of music ability, with the degree of music aptitude varying, not only from individual to individual, but across various components of music ability within the same individual. While environmental factors influencing music development and expertise have been well investigated in the psychological and music literature, the interrogation of possible genetic influences has not progressed at the same rate. Recent advances in genetic research offer fertile ground for exploring the genetic basis of music ability. This paper begins with a brief overview of behavioral and molecular genetic approaches commonly used in human genetic analyses, and then critically reviews the key findings of genetic investigations of the components of music ability. Some promising and converging findings have emerged, with several loci on chromosome 4 implicated in singing and music perception, and certain loci on chromosome 8q implicated in absolute pitch and music perception. The gene AVPR1A on chromosome 12q has also been implicated in music perception, music memory, and music listening, whereas SLC6A4 on chromosome 17q has been associated with music memory and choir participation. Replication of these results in alternate populations and with larger samples is warranted to confirm the findings. Through increased research efforts, a clearer picture of the genetic mechanisms underpinning music ability will hopefully emerge.

  1. Molecular basis of the irritable bowel syndrome

    PubMed Central

    Vaiopoulou, Anna; Karamanolis, Georgios; Psaltopoulou, Theodora; Karatzias, George; Gazouli, Maria

    2014-01-01

    Irritable bowel syndrome (IBS) is a functional disorder characterized by abdominal pain, discomfort and bloating. The pathophysiology of IBS is poorly understood, but the presence of psychosocial basis is now known. There is an increasing number of publications supporting the role of genetics in IBS. Most of the variations are found in genes associated with the brain-gut axis, revealing the strong correlation of brain-gut axis and IBS. miRNAs, which play critical roles in physiological processes, are not well studied in IBS. However, so far there is found an involvement of alterations in miRNA expression or sequence, in IBS symptoms. IBS phenotype is affected by epigenetic alteration and environment. Changes in DNA and histone methylation are observed in patients who suffered childhood trauma or abuse, resulting in altered gene expression, such as the glucocorticoid receptor gene. Finally, diet is another factor associated with IBS, which may contribute to symptom onset. Certain foods may affect on bacterial metabolism and epigenetic modifications, predisposing to IBS. PMID:24574707

  2. The neural basis of altruistic punishment.

    PubMed

    de Quervain, Dominique J-F; Fischbacher, Urs; Treyer, Valerie; Schellhammer, Melanie; Schnyder, Ulrich; Buck, Alfred; Fehr, Ernst

    2004-08-27

    Many people voluntarily incur costs to punish violations of social norms. Evolutionary models and empirical evidence indicate that such altruistic punishment has been a decisive force in the evolution of human cooperation. We used H2 15O positron emission tomography to examine the neural basis for altruistic punishment of defectors in an economic exchange. Subjects could punish defection either symbolically or effectively. Symbolic punishment did not reduce the defector's economic payoff, whereas effective punishment did reduce the payoff. We scanned the subjects' brains while they learned about the defector's abuse of trust and determined the punishment. Effective punishment, as compared with symbolic punishment, activated the dorsal striatum, which has been implicated in the processing of rewards that accrue as a result of goal-directed actions. Moreover, subjects with stronger activations in the dorsal striatum were willing to incur greater costs in order to punish. Our findings support the hypothesis that people derive satisfaction from punishing norm violations and that the activation in the dorsal striatum reflects the anticipated satisfaction from punishing defectors.

  3. The molecular basis of lactose intolerance.

    PubMed

    Campbell, Anthony K; Waud, Jonathan P; Matthews, Stephanie B

    2005-01-01

    A staggering 4000 million people cannot digest lactose, the sugar in milk, properly. All mammals, apart from white Northern Europeans and few tribes in Africa and Asia, lose most of their lactase, the enzyme that cleaves lactose into galactose and glucose, after weaning. Lactose intolerance causes gut and a range of systemic symptoms, though the threshold to lactose varies considerably between ethnic groups and individuals within a group. The molecular basis of inherited hypolactasia has yet to be identified, though two polymorphisms in the introns of a helicase upstream from the lactase gene correlate closely with hypolactasia, and thus lactose intolerance. The symptoms of lactose intolerance are caused by gases and toxins produced by anaerobic bacteria in the large intestine. Bacterial toxins may play a key role in several other diseases, such as diabetes, rheumatoid arthritis, multiple sclerosis and some cancers. The problem of lactose intolerance has been exacerbated because of the addition of products containing lactose to various foods and drinks without being on the label. Lactose intolerance fits exactly the illness that Charles Darwin suffered from for over 40 years, and yet was never diagnosed. Darwin missed something else--the key to our own evolution--the Rubicon some 300 million years ago that produced lactose and lactase in sufficient amounts to be susceptible to natural selection.

  4. Molecular Basis of ABHD5 Lipolysis Activation

    PubMed Central

    Sanders, Matthew A.; Zhang, Huamei; Mladenovic, Ljiljana; Tseng, Yan Yuan; Granneman, James G.

    2017-01-01

    Alpha-beta hydrolase domain-containing 5 (ABHD5), the defective gene in human Chanarin-Dorfman syndrome, is a highly conserved regulator of adipose triglyceride lipase (ATGL)-mediated lipolysis that plays important roles in metabolism, tumor progression, viral replication, and skin barrier formation. The structural determinants of ABHD5 lipolysis activation, however, are unknown. We performed comparative evolutionary analysis and structural modeling of ABHD5 and ABHD4, a functionally distinct paralog that diverged from ABHD5 ~500 million years ago, to identify determinants of ABHD5 lipolysis activation. Two highly conserved ABHD5 amino acids (R299 and G328) enabled ABHD4 (ABHD4 N303R/S332G) to activate ATGL in Cos7 cells, brown adipocytes, and artificial lipid droplets. The corresponding ABHD5 mutations (ABHD5 R299N and ABHD5 G328S) selectively disrupted lipolysis without affecting ATGL lipid droplet translocation or ABHD5 interactions with perilipin proteins and ABHD5 ligands, demonstrating that ABHD5 lipase activation could be dissociated from its other functions. Structural modeling placed ABHD5 R299/G328 and R303/G332 from gain-of-function ABHD4 in close proximity on the ABHD protein surface, indicating they form part of a novel functional surface required for lipase activation. These data demonstrate distinct ABHD5 functional properties and provide new insights into the functional evolution of ABHD family members and the structural basis of lipase regulation. PMID:28211464

  5. The molecular basis of lactose intolerance.

    PubMed

    Campbell, Anthony K; Waud, Jonathan P; Matthews, Stephanie B

    2009-01-01

    A staggering 4000 million people cannot digest lactose, the sugar in milk, properly. All mammals, apart from white Northern Europeans and few tribes in Africa and Asia, lose most of their lactase, the enzyme that cleaves lactose into galactose and glucose, after weaning. Lactose intolerance causes gut and a range of systemic symptoms, though the threshold to lactose varies considerably between ethnic groups and individuals within a group. The molecular basis of inherited hypolactasia has yet to be identified, though two polymorphisms in the introns of a helicase upstream from the lactase gene correlate closely with hypolactasia, and thus lactose intolerance. The symptoms of lactose intolerance are caused by gases and toxins produced by anaerobic bacteria in the large intestine. Bacterial toxins may play a key role in several other diseases, such as diabetes, rheumatoid arthritis, multiple sclerosis and some cancers. The problem of lactose intolerance has been exacerbated because of the addition of products containing lactose to various foods and drinks without being on the label. Lactose intolerance fits exactly the illness that Charles Darwin suffered from for over 40 years, and yet was never diagnosed. Darwin missed something else--the key to our own evolution--the Rubicon some 300 million years ago that produced lactose and lactase in sufficient amounts to be susceptible to natural selection.

  6. The neural basis of the imitation drive.

    PubMed

    Hanawa, Sugiko; Sugiura, Motoaki; Nozawa, Takayuki; Kotozaki, Yuka; Yomogida, Yukihito; Ihara, Mizuki; Akimoto, Yoritaka; Thyreau, Benjamin; Izumi, Shinichi; Kawashima, Ryuta

    2016-01-01

    Spontaneous imitation is assumed to underlie the acquisition of important skills by infants, including language and social interaction. In this study, functional magnetic resonance imaging (fMRI) was used to examine the neural basis of 'spontaneously' driven imitation, which has not yet been fully investigated. Healthy participants were presented with movie clips of meaningless bimanual actions and instructed to observe and imitate them during an fMRI scan. The participants were subsequently shown the movie clips again and asked to evaluate the strength of their 'urge to imitate' (Urge) for each action. We searched for cortical areas where the degree of activation positively correlated with Urge scores; significant positive correlations were observed in the right supplementary motor area (SMA) and bilateral midcingulate cortex (MCC) under the imitation condition. These areas were not explained by explicit reasons for imitation or the kinematic characteristics of the actions. Previous studies performed in monkeys and humans have implicated the SMA and MCC/caudal cingulate zone in voluntary actions. This study also confirmed the functional connectivity between Urge and imitation performance using a psychophysiological interaction analysis. Thus, our findings reveal the critical neural components that underlie spontaneous imitation and provide possible reasons why infants imitate spontaneously. © The Author (2015). Published by Oxford University Press.

  7. Neurobiological basis of motivational deficits in psychopathology.

    PubMed

    Salamone, John D; Koychev, Ivan; Correa, Mercè; McGuire, Philip

    2015-08-01

    In recent years, there has been increasing emphasis on the importance of motivational symptoms in depression, schizophrenia and other disorders. The present review discusses the conceptual background related to the construct of motivation, and provides a framework that for research on both physiological and pathological aspects of motivation. Particular emphasis is placed on what is known about the neurobiological basis of activational aspects of motivation, including studies from animal models. The role of limbic/prefrontal/striatal circuitry in behavioral activation and effort-related functions is examined, and the utility of behavioral tasks of effort-based decision making as models of motivational symptoms is discussed. We also review the neurobiology of motivational symptoms in relation to psychopathology, and issues related to the language used to characterize motivational dysfunctions are considered. The literature suggests that research on the neurobiology of motivational dysfunction in psychopathology, at both clinical and preclinical levels, could inform the development of novel and more effective treatments for a range of CNS disorders.

  8. Quantitative microbiology: a basis for food safety.

    PubMed Central

    McMeekin, T. A.; Brown, J.; Krist, K.; Miles, D.; Neumeyer, K.; Nichols, D. S.; Olley, J.; Presser, K.; Ratkowsky, D. A.; Ross, T.; Salter, M.; Soontranon, S.

    1997-01-01

    Because microorganisms are easily dispersed, display physiologic diversity, and tolerate extreme conditions, they are ubiquitous and may contaminate and grow in many food products. The behavior of microbial populations in foods (growth, survival, or death) is determined by the properties of the food (e.g., water activity and pH) and the storage conditions (e.g., temperature, relative humidity, and atmosphere). The effect of these properties can be predicted by mathematical models derived from quantitative studies on microbial populations. Temperature abuse is a major factor contributing to foodborne disease; monitoring temperature history during food processing, distribution, and storage is a simple, effective means to reduce the incidence of food poisoning. Interpretation of temperature profiles by computer programs based on predictive models allows informed decisions on the shelf life and safety of foods. In- or on-package temperature indicators require further development to accurately predict microbial behavior. We suggest a basis for a "universal" temperature indicator. This article emphasizes the need to combine kinetic and probability approaches to modeling and suggests a method to define the bacterial growth/no growth interface. Advances in controlling foodborne pathogens depend on understanding the pathogens' physiologic responses to growth constraints, including constraints conferring increased survival capacity. PMID:9366608

  9. Human Papillomaviruses: Genetic Basis of Carcinogenicity

    PubMed Central

    Burk, Robert D.; Chen, Zigui; Van Doorslaer, Koenraad

    2009-01-01

    Persistent infection by specific oncogenic human papillomaviruses (HPVs) is established as the necessary cause of cervix cancer. DNA sequence differences between HPV genomes determine whether an HPV has the potential to cause cancer. Of the more than 100 HPV genotypes characterized at the genetic level, at least 15 are associated, to varying degrees, with cervical cancer. Classification based on nucleotide similarity places nearly all HPVs that infect the cervicovaginal area within the α-PV genus. Within this genus, phylogenetic trees inferred from the entire viral genome cluster all cancer-causing types together, suggesting the existence of a common ancestor for the oncogenic HPVs. However, in separate trees built from the early open reading frames (ORFs; i.e. E1, E2, E6, E7) or the late ORFs (i.e. L1, L2), the carcinogenic potential sorts with the early region of the genome, but not the late region. Thus, genetic differences within the early region specify the pathogenic potential of α-HPV infections. Since the HPV genomes are monophyletic and sites are highly correlated across the genome, diagnosis of oncogenic types and non-oncogenic types can be accomplished using any region across the genome. Here we review our current understanding of the evolutionary history of the oncogenic HPVs, in particular, we focus on the importance of viral genome heterogeneity and discuss the genetic basis for the oncogenic phenotype in some but not all α-PVs. PMID:19684441

  10. Global embedding via coordinate basis vectors

    NASA Astrophysics Data System (ADS)

    Goedecke, G. H.

    2011-03-01

    Following the work reported in an earlier paper (G.H. Goedecke, J. Math. Phys. 15, 789 (1974)), the coordinate basis vector approach to tensor calculus is exploited fully to obtain additional and stronger results, including: i) any curved Riemannian space must be a subspace of a larger flat host space; ii) a free test particle moves uniformly on a geodesic in the host space, but experiences gravity and other pseudoforces as viewed in four-dimensional (4D) spacetime; iii) the 4D Riemann-Christoffel curvature tensor is identically equal to a geometrical tensor associated with the complementary subspace of the host space; iv) Einstein's field equations are automatically geometrized, with the stress-energy tensor expressed in terms of the contracted complementary tensor; v) there cannot be a conventional cosmological term in these field equations, except as an approximation; vi) other geometrical field equations involving the complementary subspace metric fields exist and should be physical equations; vii) the long-range two-body time-independent central forces due to all metric fields that have localized sources are inverse square or generalized Yukawa forces. Some of the relationships between this theory and Kaluza-Klein (KK) and string theories are noted; for example, some of the results derived herein must be postulated in KK theories.

  11. Introduction: the structural basis of virus function.

    PubMed

    Mateu, Mauricio G

    2013-01-01

    Viruses may be regarded as dynamic nucleoprotein assemblies capable of assisted multiplication within cells, and of propagation between cells and organisms. Infectious virus particles (virions) assembled in a host cell are dynamic, generally metastable particles: They are robust enough to protect the viral genome outside the cell, but are also poised to undergo structural changes and execute mechanochemical actions required for infection of other cells. This chapter provides an introduction to the structural and physical biology of viruses by including: (i) an elementary overview on virions and the structural basis of virus function; (ii) a concise summary on basic techniques used in structural or physical virology; (iii) brief structure-based general descriptions of the different stages in the virus cycle, especially those in which virions and/or their components are involved. These contents may facilitate a better understanding of the specialized subjects treated in the rest of the book. This chapter is also intended as a "road map" to help interconnect and integrate in a single picture the different topics described in depth in the 21 monographic chapters in this book.

  12. A radial basis function Galerkin method for inhomogeneous nonlocal diffusion

    DOE PAGES

    Lehoucq, Richard B.; Rowe, Stephen T.

    2016-02-01

    We introduce a discretization for a nonlocal diffusion problem using a localized basis of radial basis functions. The stiffness matrix entries are assembled by a special quadrature routine unique to the localized basis. Combining the quadrature method with the localized basis produces a well-conditioned, sparse, symmetric positive definite stiffness matrix. We demonstrate that both the continuum and discrete problems are well-posed and present numerical results for the convergence behavior of the radial basis function method. As a result, we explore approximating the solution to anisotropic differential equations by solving anisotropic nonlocal integral equations using the radial basis function method.

  13. PARFUME Theory and Model basis Report

    SciTech Connect

    Darrell L. Knudson; Gregory K Miller; G.K. Miller; D.A. Petti; J.T. Maki; D.L. Knudson

    2009-09-01

    The success of gas reactors depends upon the safety and quality of the coated particle fuel. The fuel performance modeling code PARFUME simulates the mechanical, thermal and physico-chemical behavior of fuel particles during irradiation. This report documents the theory and material properties behind vari¬ous capabilities of the code, which include: 1) various options for calculating CO production and fission product gas release, 2) an analytical solution for stresses in the coating layers that accounts for irradiation-induced creep and swelling of the pyrocarbon layers, 3) a thermal model that calculates a time-dependent temperature profile through a pebble bed sphere or a prismatic block core, as well as through the layers of each analyzed particle, 4) simulation of multi-dimensional particle behavior associated with cracking in the IPyC layer, partial debonding of the IPyC from the SiC, particle asphericity, and kernel migration (or amoeba effect), 5) two independent methods for determining particle failure probabilities, 6) a model for calculating release-to-birth (R/B) ratios of gaseous fission products that accounts for particle failures and uranium contamination in the fuel matrix, and 7) the evaluation of an accident condition, where a particle experiences a sudden change in temperature following a period of normal irradiation. The accident condi¬tion entails diffusion of fission products through the particle coating layers and through the fuel matrix to the coolant boundary. This document represents the initial version of the PARFUME Theory and Model Basis Report. More detailed descriptions will be provided in future revisions.

  14. The genetic basis of music ability

    PubMed Central

    Tan, Yi Ting; McPherson, Gary E.; Peretz, Isabelle; Berkovic, Samuel F.; Wilson, Sarah J.

    2014-01-01

    Music is an integral part of the cultural heritage of all known human societies, with the capacity for music perception and production present in most people. Researchers generally agree that both genetic and environmental factors contribute to the broader realization of music ability, with the degree of music aptitude varying, not only from individual to individual, but across various components of music ability within the same individual. While environmental factors influencing music development and expertise have been well investigated in the psychological and music literature, the interrogation of possible genetic influences has not progressed at the same rate. Recent advances in genetic research offer fertile ground for exploring the genetic basis of music ability. This paper begins with a brief overview of behavioral and molecular genetic approaches commonly used in human genetic analyses, and then critically reviews the key findings of genetic investigations of the components of music ability. Some promising and converging findings have emerged, with several loci on chromosome 4 implicated in singing and music perception, and certain loci on chromosome 8q implicated in absolute pitch and music perception. The gene AVPR1A on chromosome 12q has also been implicated in music perception, music memory, and music listening, whereas SLC6A4 on chromosome 17q has been associated with music memory and choir participation. Replication of these results in alternate populations and with larger samples is warranted to confirm the findings. Through increased research efforts, a clearer picture of the genetic mechanisms underpinning music ability will hopefully emerge. PMID:25018744

  15. Neural basis of economic bubble behavior.

    PubMed

    Ogawa, A; Onozaki, T; Mizuno, T; Asamizuya, T; Ueno, K; Cheng, K; Iriki, A

    2014-04-18

    Throughout human history, economic bubbles have formed and burst. As a bubble grows, microeconomic behavior ceases to be constrained by realistic predictions. This contradicts the basic assumption of economics that agents have rational expectations. To examine the neural basis of behavior during bubbles, we performed functional magnetic resonance imaging while participants traded shares in a virtual stock exchange with two non-bubble stocks and one bubble stock. The price was largely deflected from the fair price in one of the non-bubble stocks, but not in the other. Their fair prices were specified. The price of the bubble stock showed a large increase and battering, as based on a real stock-market bust. The imaging results revealed modulation of the brain circuits that regulate trade behavior under different market conditions. The premotor cortex was activated only under a market condition in which the price was largely deflected from the fair price specified. During the bubble, brain regions associated with the cognitive processing that supports order decisions were identified. The asset preference that might bias the decision was associated with the ventrolateral prefrontal cortex and the dorsolateral prefrontal cortex (DLPFC). The activity of the inferior parietal lobule (IPL) was correlated with the score of future time perspective, which would bias the estimation of future price. These regions were deemed to form a distinctive network during the bubble. A functional connectivity analysis showed that the connectivity between the DLPFC and the IPL was predominant compared with other connectivities only during the bubble. These findings indicate that uncertain and unstable market conditions changed brain modes in traders. These brain mechanisms might lead to a loss of control caused by wishful thinking, and to microeconomic bubbles that expand, on the macroscopic scale, toward bust. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  16. Enzymatic Basis for N-Glycan Sialylation

    PubMed Central

    Meng, Lu; Forouhar, Farhad; Thieker, David; Gao, Zhongwei; Ramiah, Annapoorani; Moniz, Heather; Xiang, Yong; Seetharaman, Jayaraman; Milaninia, Sahand; Su, Min; Bridger, Robert; Veillon, Lucas; Azadi, Parastoo; Kornhaber, Gregory; Wells, Lance; Montelione, Gaetano T.; Woods, Robert J.; Tong, Liang; Moremen, Kelley W.

    2013-01-01

    Glycan structures on glycoproteins and glycolipids play critical roles in biological recognition, targeting, and modulation of functions in animal systems. Many classes of glycan structures are capped with terminal sialic acid residues, which contribute to biological functions by either forming or masking glycan recognition sites on the cell surface or secreted glycoconjugates. Sialylated glycans are synthesized in mammals by a single conserved family of sialyltransferases that have diverse linkage and acceptor specificities. We examined the enzymatic basis for glycan sialylation in animal systems by determining the crystal structures of rat ST6GAL1, an enzyme that creates terminal α2,6-sialic acid linkages on complex-type N-glycans, at 2.4 Å resolution. Crystals were obtained from enzyme preparations generated in mammalian cells. The resulting structure revealed an overall protein fold broadly resembling the previously determined structure of pig ST3GAL1, including a CMP-sialic acid-binding site assembled from conserved sialylmotif sequence elements. Significant differences in structure and disulfide bonding patterns were found outside the sialylmotif sequences, including differences in residues predicted to interact with the glycan acceptor. Computational substrate docking and molecular dynamics simulations were performed to predict and evaluate the CMP-sialic acid donor and glycan acceptor interactions, and the results were compared with kinetic analysis of active site mutants. Comparisons of the structure with pig ST3GAL1 and a bacterial sialyltransferase revealed a similar positioning of donor, acceptor, and catalytic residues that provide a common structural framework for catalysis by the mammalian and bacterial sialyltransferases. PMID:24155237

  17. Accelerated Best Basis Inventory Baselining Task

    SciTech Connect

    SASAKI, L.M.

    2001-10-19

    The baselining effort was recently proposed to bring the Best-Basis Inventory (BBI) and Question No.8 of the Tank Interpretive Report (TIR) for all 177 tanks to the current standards and protocols and to prepare a TIR Question No.8 if one is not already available. This plan outlines the objectives and methodology of the accelerated BBI baselining task. BBI baselining meetings held during December 2000 resulted in a revised BBI methodology and an initial set of BBI creation rules to be used in the baselining effort. The objectives of the BBI baselining effort are to: (1) Provide inventories that are consistent with the revised BBI methodology and new BBI creation rules. (2) Split the total tank waste in each tank into six waste phases, as appropriate (Supernatant, saltcake solids, saltcake liquid, sludge solids, sludge liquid, and retained gas). In some tanks, the solids and liquid portions of the sludge and/or saltcake may be combined into a single sludge or saltcake phase. (3) Identify sampling events that are to be used for calculating the BBIs. (4) Update waste volumes for subsequent reconciliation with the Hanlon (2001) waste tank summary. (5) Implement new waste type templates. (6) Include any sample data that might have been unintentionally omitted in the previous BBI and remove any sample data that should not have been included. Sample data to be used in the BBI must be available on TWINS. (7) Ensure that an inventory value for each standard BBI analyte is provided for each waste component. Sample based inventories for supplemental BBI analytes will be included when available. (8) Provide new means and confidence interval reports if one is not already available and include uncertainties in reporting inventory values.

  18. Structural basis of kynurenine 3-monooxygenase inhibition

    PubMed Central

    Amaral, Marta; Levy, Colin; Heyes, Derren J.; Lafite, Pierre; Outeiro, Tiago F.; Giorgini, Flaviano; Leys, David; Scrutton, Nigel S.

    2013-01-01

    Inhibition of kynurenine 3-monooxygenase (KMO), an enzyme in the eukaryotic tryptophan catabolic pathway (i.e. kynurenine pathway), leads to amelioration of Huntington’s disease-relevant phenotypes in yeast, fruit fly, and mouse models1–5, as well as a mouse model of Alzheimer’s disease3. KMO is a FAD-dependent monooxygenase, and is located in the outer mitochondrial membrane where it converts L-kynurenine to 3-hydroxykynurenine. Perturbations in the levels of kynurenine pathway metabolites have been linked to the pathogenesis of a spectrum of brain disorders6, as well as cancer7,8, and several peripheral inflammatory conditions9. Despite the importance of KMO as a target for neurodegenerative disease, the molecular basis of KMO inhibition by available lead compounds has remained hitherto unknown. Here we report the first crystal structure of KMO, in the free form and in complex with the tight-binding inhibitor UPF 648. UPF 648 binds close to the FAD cofactor and perturbs the local active site structure, preventing productive binding of the substrate kynurenine. Functional assays and targeted mutagenesis revealed that the active site architecture and UPF 648 binding are essentially identical in human KMO, validating the yeast KMO:UPF 648 structure as a template for structure-based drug design. This will inform the search for new KMO inhibitors that are able to cross the blood-brain barrier in targeted therapies against neurodegenerative diseases such as Huntington’s, Alzheimer’s, and Parkinson’s diseases. PMID:23575632

  19. Deciphering the Chemical Basis of Nestmate Recognition

    PubMed Central

    Sulc, Robert; Shea, Kenneth J.; Tsutsui, Neil D.

    2010-01-01

    Social insects maintain colony cohesion by recognizing and, if necessary, discriminating against conspecifics that are not part of the colony. This recognition ability is encoded by a complex mixture of cuticular hydrocarbons (CHCs), although it is largely unclear how social insects interpret such a multifaceted signal. CHC profiles often contain several series of homologous hydrocarbons, possessing the same methyl branch position but differing in chain length (e.g., 15-methyl-pentatriacontane, 15-methyl-heptatriacontane, 15-methyl-nonatriacontane). Recent studies have revealed that within species these homologs can occur in correlated concentrations. In such cases, single compounds may convey the same information as the homologs. In this study, we used behavioral bioassays to explore how social insects perceive and interpret different hydrocarbons. We tested the aggressive response of Argentine ants, Linepithema humile, toward nest-mate CHC profiles that were augmented with one of eight synthetic hydrocarbons that differed in branch position, chain length, or both. We found that Argentine ants showed similar levels of aggression toward nest-mate CHC profiles augmented with compounds that had the same branch position but differed in chain length. Conversely, Argentine ants displayed different levels of aggression toward nest-mate CHC profiles augmented with compounds that had different branch positions but the same chain length. While this was true in almost all cases, one CHC we tested elicited a greater aggressive response than its homologs. Interestingly, this was the only compound that did not occur naturally in correlated concentrations with its homologs in CHC profiles. Combined, these data suggest that CHCs of a homologous series elicit the same aggressive response because they convey the same information, rather than Argentine ants being unable to discriminate between different homologs. This study contributes to our understanding of the chemical basis of

  20. Authorization basis status report (miscellaneous TWRS facilities, tanks and components)

    SciTech Connect

    Stickney, R.G.

    1998-04-29

    This report presents the results of a systematic evaluation conducted to identify miscellaneous TWRS facilities, tanks and components with potential needed authorization basis upgrades. It provides the Authorization Basis upgrade plan for those miscellaneous TWRS facilities, tanks and components identified.

  1. 47 CFR 27.1 - Basis and purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES General Information § 27.1 Basis and purpose. This section contains the statutory basis... rules for miscellaneous wireless communications services (WCS) in this part are promulgated under...

  2. 47 CFR 27.1 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES General Information § 27.1 Basis and purpose. This section contains the statutory basis... rules for miscellaneous wireless communications services (WCS) in this part are promulgated under...

  3. 47 CFR 27.1 - Basis and purpose.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES General Information § 27.1 Basis and purpose. This section contains the statutory basis... rules for miscellaneous wireless communications services (WCS) in this part are promulgated under...

  4. 47 CFR 27.1 - Basis and purpose.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES General Information § 27.1 Basis and purpose. This section contains the statutory basis... rules for miscellaneous wireless communications services (WCS) in this part are promulgated under...

  5. 31 CFR 150.4 - Calculation of assessment basis.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... OFFICES, DEPARTMENT OF THE TREASURY FINANCIAL RESEARCH FUND § 150.4 Calculation of assessment basis. (a... basis that shall be sufficient to replenish the Financial Research Fund to a level equivalent to the sum...

  6. 31 CFR 150.4 - Calculation of assessment basis.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... OFFICES, DEPARTMENT OF THE TREASURY FINANCIAL RESEARCH FUND § 150.4 Calculation of assessment basis. (a... basis that shall be sufficient to replenish the Financial Research Fund to a level equivalent to the sum...

  7. 16 CFR 1203.51 - Purpose and basis.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... STANDARD FOR BICYCLE HELMETS Requirements For Bicycle Helmets Manufactured From March 17, 1995, Through March 10, 1999 § 1203.51 Purpose and basis. The purpose and basis of this subpart is to protect...

  8. Atomic Natural Orbital Basis Sets for Transition Metals

    NASA Technical Reports Server (NTRS)

    Bauschlicher, Charles W., Jr.; Taylor, Peter R.

    1993-01-01

    We show that atomic natural orbitals are an excellent way to contract transition-metal basis sets, even though the different low-lying electronic states may have very different basis set requirements.

  9. 10 CFR 72.92 - Design basis external natural events.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Design basis external natural events. 72.92 Section 72.92... Evaluation Factors § 72.92 Design basis external natural events. (a) Natural phenomena that may exist or that... must be adopted for evaluating the design basis external natural events based on the characteristics...

  10. 10 CFR 72.92 - Design basis external natural events.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Design basis external natural events. 72.92 Section 72.92... Evaluation Factors § 72.92 Design basis external natural events. (a) Natural phenomena that may exist or that... must be adopted for evaluating the design basis external natural events based on the characteristics...

  11. 10 CFR 72.92 - Design basis external natural events.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Design basis external natural events. 72.92 Section 72.92... Evaluation Factors § 72.92 Design basis external natural events. (a) Natural phenomena that may exist or that... must be adopted for evaluating the design basis external natural events based on the characteristics...

  12. 10 CFR 72.92 - Design basis external natural events.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Design basis external natural events. 72.92 Section 72.92... Evaluation Factors § 72.92 Design basis external natural events. (a) Natural phenomena that may exist or that... must be adopted for evaluating the design basis external natural events based on the characteristics...

  13. 10 CFR 72.92 - Design basis external natural events.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Design basis external natural events. 72.92 Section 72.92... Evaluation Factors § 72.92 Design basis external natural events. (a) Natural phenomena that may exist or that... must be adopted for evaluating the design basis external natural events based on the characteristics...

  14. 26 CFR 1.358-1 - Basis to distributees.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... transaction, the sum of the basis of all of the stock and securities received in the transaction shall be the same as the basis of all the stock and securities in such corporation surrendered in the transaction... property is received, immediately after the transaction, the sum of the basis of all of the stock and...

  15. 9 CFR 590.130 - Basis of billing plants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Basis of billing plants. 590.130... of Service § 590.130 Basis of billing plants. Overtime and/or holiday services shall be billed to the official plant on the basis of each 15 minutes of overtime and/or holiday service performed by...

  16. 9 CFR 590.130 - Basis of billing plants.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Basis of billing plants. 590.130... of Service § 590.130 Basis of billing plants. Overtime and/or holiday services shall be billed to the official plant on the basis of each 15 minutes of overtime and/or holiday service performed by...

  17. 9 CFR 590.130 - Basis of billing plants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Basis of billing plants. 590.130... of Service § 590.130 Basis of billing plants. Overtime and/or holiday services shall be billed to the official plant on the basis of each 15 minutes of overtime and/or holiday service performed by...

  18. 10 CFR 13.1 - Basis and purpose.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Basis and purpose. 13.1 Section 13.1 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.1 Basis and purpose. (a) Basis. This part implements the Program Fraud Civil Remedies Act of 1986, Public Law No. 99-509, §§ 6101-6104, 100 Stat....

  19. 16 CFR 1203.2 - Purpose and basis.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Purpose and basis. 1203.2 Section 1203.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS The Standard § 1203.2 Purpose and basis. The purpose and basis of...

  20. 42 CFR 403.500 - Basis, scope, and definition.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Basis, scope, and definition. 403.500 Section 403... Basis, scope, and definition. (a) Basis. This subpart implements, in part, the provisions of section... purpose of providing information, counseling, and assistance relating to obtaining adequate and...

  1. 16 CFR 1203.2 - Purpose and basis.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Purpose and basis. 1203.2 Section 1203.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS The Standard § 1203.2 Purpose and basis. The purpose and basis of this...

  2. 16 CFR 1203.2 - Purpose and basis.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Purpose and basis. 1203.2 Section 1203.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS The Standard § 1203.2 Purpose and basis. The purpose and basis of this...

  3. 16 CFR 1203.2 - Purpose and basis.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Purpose and basis. 1203.2 Section 1203.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS The Standard § 1203.2 Purpose and basis. The purpose and basis of this...

  4. 16 CFR 1203.2 - Purpose and basis.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Purpose and basis. 1203.2 Section 1203.2 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR BICYCLE HELMETS The Standard § 1203.2 Purpose and basis. The purpose and basis of this...

  5. 10 CFR 830.207 - DOE approval of safety basis.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false DOE approval of safety basis. 830.207 Section 830.207 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.207 DOE approval of... DOE nuclear facility must submit for DOE approval a safety basis that meets the requirements of this...

  6. 10 CFR 830.207 - DOE approval of safety basis.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false DOE approval of safety basis. 830.207 Section 830.207 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.207 DOE approval of... DOE nuclear facility must submit for DOE approval a safety basis that meets the requirements of this...

  7. 10 CFR 830.207 - DOE approval of safety basis.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false DOE approval of safety basis. 830.207 Section 830.207 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.207 DOE approval of... DOE nuclear facility must submit for DOE approval a safety basis that meets the requirements of this...

  8. 10 CFR 830.207 - DOE approval of safety basis.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false DOE approval of safety basis. 830.207 Section 830.207 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.207 DOE approval of... DOE nuclear facility must submit for DOE approval a safety basis that meets the requirements of this...

  9. 10 CFR 830.207 - DOE approval of safety basis.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false DOE approval of safety basis. 830.207 Section 830.207 Energy DEPARTMENT OF ENERGY NUCLEAR SAFETY MANAGEMENT Safety Basis Requirements § 830.207 DOE approval of... DOE nuclear facility must submit for DOE approval a safety basis that meets the requirements of this...

  10. 42 CFR 417.530 - Basis and scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Basis and scope. 417.530 Section 417.530 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... PLANS Medicare Payment: Cost Basis § 417.530 Basis and scope. This subpart sets forth the principles...

  11. 42 CFR 417.530 - Basis and scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Basis and scope. 417.530 Section 417.530 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... PREPAYMENT PLANS Medicare Payment: Cost Basis § 417.530 Basis and scope. This subpart sets forth the...

  12. 9 CFR 590.130 - Basis of billing plants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Basis of billing plants. 590.130... of Service § 590.130 Basis of billing plants. Overtime and/or holiday services shall be billed to the official plant on the basis of each 15 minutes of overtime and/or holiday service performed by each...

  13. Understanding the Social Basis of Adolescent Body Image.

    ERIC Educational Resources Information Center

    Bornholt, L. J.

    It is apparent from current research and professional experience that body image has a strong social basis, but the form of such comparisons is unclear. Therefore, the aim of this study is to examine likely forms of the social basis of adolescent body image. This study compares two approaches to the social basis of body image to ask to what extent…

  14. 46 CFR 287.17 - Basis of new vessel.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 8 2011-10-01 2011-10-01 false Basis of new vessel. 287.17 Section 287.17 Shipping... OPERATORS ESTABLISHMENT OF CONSTRUCTION RESERVE FUNDS § 287.17 Basis of new vessel. The basis for determining gain or loss and for depreciation for the purpose of the Federal income tax with respect to a new...

  15. 26 CFR 2.1-17 - Basis of new vessel.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 14 2014-04-01 2013-04-01 true Basis of new vessel. 2.1-17 Section 2.1-17...) MARITIME CONSTRUCTION RESERVE FUND § 2.1-17 Basis of new vessel. The basis for determining gain or loss and for depreciation for the purpose of the Federal income tax with respect to a new vessel constructed...

  16. 22 CFR 521.1 - Basis and purpose.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Basis and purpose. 521.1 Section 521.1 Foreign... Basis and purpose. (a) Basis. This part implements the Program Fraud Civil Remedies Act of 1986, Public Law 99-509, sections 6101-6104, 100 Stat. 1874 (October 21, 1986), codified at 31 U.S.C....

  17. 7 CFR 1.301 - Basis, purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Basis, purpose and scope. 1.301 Section 1.301... Administrative Hearings Under the Program Fraud Civil Remedies Act of 1986 § 1.301 Basis, purpose and scope. (a) Basis. This subpart implements the Program Fraud Civil Remedies Act of 1986, Public Law No....

  18. 14 CFR 1264.100 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Basis and purpose. 1264.100 Section 1264... FRAUD CIVIL PENALTIES ACT OF 1986 § 1264.100 Basis and purpose. (a) Basis. This part implements the Program Fraud Civil Remedies Act of 1986, Pub. L. 99-509, sections 6101-6104, 100 Stat. 1874 (October...

  19. 32 CFR 1633.8 - Basis of classification.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Basis of classification. 1633.8 Section 1633.8 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM ADMINISTRATION OF CLASSIFICATION § 1633.8 Basis of classification. The registrant's classification shall be determined on the basis...

  20. 37 CFR 41.120 - Notice of basis for relief.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Notice of basis for relief... Notice of basis for relief. (a) The Board may require a party to provide a notice stating the relief it requests and the basis for its entitlement to relief. The Board may provide for the notice to be maintained...

  1. 6 CFR 13.1 - Basis, purpose, scope and effect.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Basis, purpose, scope and effect. 13.1 Section... REMEDIES § 13.1 Basis, purpose, scope and effect. (a) Basis. This part implements the Program Fraud Civil... Persons who Make, submit, or present, or cause to be Made, submitted, or presented, false, fictitious,...

  2. 45 CFR 155.1300 - Basis and purpose.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Basis and purpose. 155.1300 Section 155.1300 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS... Flexibility § 155.1300 Basis and purpose. (a) Statutory basis. This subpart implements provisions of...

  3. 45 CFR 155.1300 - Basis and purpose.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Basis and purpose. 155.1300 Section 155.1300 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS... Flexibility § 155.1300 Basis and purpose. (a) Statutory basis. This subpart implements provisions of...

  4. 42 CFR 402.200 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Basis and purpose. 402.200 Section 402.200 Public... PROVISIONS CIVIL MONEY PENALTIES, ASSESSMENTS, AND EXCLUSIONS Exclusions § 402.200 Basis and purpose. (a) Basis. This subpart is based on the sections of the Act that are specified in § 402.1(e). (b) Purpose...

  5. 7 CFR 810.1403 - Basis of determination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Basis of determination. Each determination of broken kernels and foreign material is made on the basis of the grain when free from dockage. Each determination of class, damaged kernels, heat-damaged kernels, and stones is made on the basis of the grain when free from dockage and that portion of...

  6. 42 CFR 485.900 - Basis and scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...: Community Mental Health Centers (CMHCs) § 485.900 Basis and scope. (a) Basis. This subpart is based on the... 42 Public Health 5 2014-10-01 2014-10-01 false Basis and scope. 485.900 Section 485.900 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  7. 42 CFR 403.300 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Basis and purpose. 403.300 Section 403.300 Public... PROVISIONS SPECIAL PROGRAMS AND PROJECTS Recognition of State Reimbursement Control Systems § 403.300 Basis and purpose. (a) Basis. This subpart implements section 1886(c) of the Act, which authorizes payment...

  8. 38 CFR 42.1 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Basis and purpose. 42.1 Section 42.1 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) STANDARDS IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.1 Basis and purpose. (a) Basis. This part implements...

  9. 38 CFR 42.1 - Basis and purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Basis and purpose. 42.1 Section 42.1 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) STANDARDS IMPLEMENTING THE PROGRAM FRAUD CIVIL REMEDIES ACT § 42.1 Basis and purpose. (a) Basis. This part implements...

  10. 20 CFR 355.1 - Basis and purpose.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Basis and purpose. 355.1 Section 355.1... REGULATIONS UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.1 Basis and purpose. (a) Basis. This part... fraudulent claims or written statements to authorities or to their agents, and (2) Specifies the hearing and...

  11. 20 CFR 355.1 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Basis and purpose. 355.1 Section 355.1... REGULATIONS UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.1 Basis and purpose. (a) Basis. This part... fraudulent claims or written statements to authorities or to their agents, and (2) Specifies the hearing and...

  12. 20 CFR 355.1 - Basis and purpose.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Basis and purpose. 355.1 Section 355.1... REGULATIONS UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.1 Basis and purpose. (a) Basis. This part... fraudulent claims or written statements to authorities or to their agents, and (2) Specifies the hearing and...

  13. 20 CFR 355.1 - Basis and purpose.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Basis and purpose. 355.1 Section 355.1... REGULATIONS UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.1 Basis and purpose. (a) Basis. This part... fraudulent claims or written statements to authorities or to their agents, and (2) Specifies the hearing and...

  14. 20 CFR 355.1 - Basis and purpose.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Basis and purpose. 355.1 Section 355.1... REGULATIONS UNDER THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 355.1 Basis and purpose. (a) Basis. This part... fraudulent claims or written statements to authorities or to their agents, and (2) Specifies the hearing and...

  15. 42 CFR 413.300 - Basis and scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Basis and scope. 413.300 Section 413.300 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM... § 413.300 Basis and scope. (a) Basis. This subpart implements section 1888(d) of the Act, which...

  16. 42 CFR 413.300 - Basis and scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Basis and scope. 413.300 Section 413.300 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM... § 413.300 Basis and scope. (a) Basis. This subpart implements section 1888(d) of the Act, which...

  17. The neural circuit basis of learning

    NASA Astrophysics Data System (ADS)

    Patrick, Kaifosh William John

    The astounding capacity for learning ranks among the nervous system's most impressive features. This thesis comprises studies employing varied approaches to improve understanding, at the level of neural circuits, of the brain's capacity for learning. The first part of the thesis contains investigations of hippocampal circuitry -- both theoretical work and experimental work in the mouse Mus musculus -- as a model system for declarative memory. To begin, Chapter 2 presents a theory of hippocampal memory storage and retrieval that reflects nonlinear dendritic processing within hippocampal pyramidal neurons. As a prelude to the experimental work that comprises the remainder of this part, Chapter 3 describes an open source software platform that we have developed for analysis of data acquired with in vivo Ca2+ imaging, the main experimental technique used throughout the remainder of this part of the thesis. As a first application of this technique, Chapter 4 characterizes the content of signaling at synapses between GABAergic neurons of the medial septum and interneurons in stratum oriens of hippocampal area CA1. Chapter 5 then combines these techniques with optogenetic, pharmacogenetic, and pharmacological manipulations to uncover inhibitory circuit mechanisms underlying fear learning. The second part of this thesis focuses on the cerebellum-like electrosensory lobe in the weakly electric mormyrid fish Gnathonemus petersii, as a model system for non-declarative memory. In Chapter 6, we study how short-duration EOD motor commands are recoded into a complex temporal basis in the granule cell layer, which can be used to cancel Purkinje-like cell firing to the longer duration and temporally varying EOD-driven sensory responses. In Chapter 7, we consider not only the temporal aspects of the granule cell code, but also the encoding of body position provided from proprioceptive and efference copy sources. Together these studies clarify how the cerebellum-like circuitry of the

  18. Entanglement patterns in mutually unbiased basis sets

    SciTech Connect

    Lawrence, Jay

    2011-08-15

    A few simply stated rules govern the entanglement patterns that can occur in mutually unbiased basis sets (MUBs) and constrain the combinations of such patterns that can coexist in full complements of MUBs. We consider Hilbert spaces of prime power dimensions (D=p{sup N}), as realized by systems of N prime-state particles, where full complements of D+1 MUBs are known to exist, and we assume only that MUBs are eigenbases of generalized Pauli operators, without using any particular construction. The general rules include the following: (1) In any MUB, a given particle appears either in a pure state or totally entangled and (2) in any full MUB complement, each particle is pure in (p+1) bases (not necessarily the same ones) and totally entangled in the remaining (p{sup N}-p). It follows that the maximum number of product bases is p+1 and, when this number is realized, all remaining (p{sup N}-p) bases in the complement are characterized by the total entanglement of every particle. This ''standard distribution'' is inescapable for two-particle systems (of any p), where only product and generalized Bell bases are admissible MUB types. This and the following results generalize previous results for qubits [Phys. Rev. A 65. 032320 (2002); Phys. Rev. A 72, 062310 (2005)] and qutrits [Phys. Rev. A 70, 012302 (2004)], drawing particularly upon [Phys. Rev. A 72, 062310 (2005)]. With three particles there are three MUB types, and these may be combined in (p+2) different ways to form full complements. With N=4, there are 6 MUB types for p=2, but new MUB types become possible with larger p, and these are essential to realizing full complements. With this example, we argue that new MUB types that show new entanglement patterns should enter with every step in N and, also, when N is a prime plus 1, at a critical p value, p=N-1. Such MUBs should play critical roles in filling complements.

  19. An improved choice of oscillator basis for banana shaped nuclides

    SciTech Connect

    Chasman, R.R.

    1994-03-01

    The question of the appropriate choice of oscillator basis functions for studying exotic nuclear shapes is raised. Difficulties with the conventional choice of oscillator basis states are noted for shapes having a large banana component. A prescription for an improved oscillator basis to study these shapes is given. It can be applied in a more general context. New calculations with this improved basis are presented for the banana deformation mode. The change of basis gives results that improve the prospects of finding states in the banana minimum for many isotopes of Tl, Pb and Bi.

  20. Local-basis-function approach to computed tomography

    NASA Astrophysics Data System (ADS)

    Hanson, K. M.; Wecksung, G. W.

    1985-12-01

    In the local basis-function approach, a reconstruction is represented as a linear expansion of basis functions, which are arranged on a rectangular grid and possess a local region of support. The basis functions considered here are positive and may overlap. It is found that basis functions based on cubic B-splines offer significant improvements in the calculational accuracy that can be achieved with iterative tomographic reconstruction algorithms. By employing repetitive basis functions, the computational effort involved in these algorithms can be minimized through the use of tabulated values for the line or strip integrals over a single-basis function. The local nature of the basis functions reduces the difficulties associated with applying local constraints on reconstruction values, such as upper and lower limits. Since a reconstruction is specified everywhere by a set of coefficients, display of a coarsely represented image does not require an arbitrary choice of an interpolation function.

  1. Optimized Basis Sets for the Environment in the Domain-Specific Basis Set Approach of the Incremental Scheme.

    PubMed

    Anacker, Tony; Hill, J Grant; Friedrich, Joachim

    2016-04-21

    Minimal basis sets, denoted DSBSenv, based on the segmented basis sets of Ahlrichs and co-workers have been developed for use as environmental basis sets for the domain-specific basis set (DSBS) incremental scheme with the aim of decreasing the CPU requirements of the incremental scheme. The use of these minimal basis sets within explicitly correlated (F12) methods has been enabled by the optimization of matching auxiliary basis sets for use in density fitting of two-electron integrals and resolution of the identity. The accuracy of these auxiliary sets has been validated by calculations on a test set containing small- to medium-sized molecules. The errors due to density fitting are about 2-4 orders of magnitude smaller than the basis set incompleteness error of the DSBSenv orbital basis sets. Additional reductions in computational cost have been tested with the reduced DSBSenv basis sets, in which the highest angular momentum functions of the DSBSenv auxiliary basis sets have been removed. The optimized and reduced basis sets are used in the framework of the domain-specific basis set of the incremental scheme to decrease the computation time without significant loss of accuracy. The computation times and accuracy of the previously used environmental basis and that optimized in this work have been validated with a test set of medium- to large-sized systems. The optimized and reduced DSBSenv basis sets decrease the CPU time by about 15.4% and 19.4% compared with the old environmental basis and retain the accuracy in the absolute energy with standard deviations of 0.99 and 1.06 kJ/mol, respectively.

  2. Basis Set Exchange: A Community Database for Computational Sciences

    SciTech Connect

    Schuchardt, Karen L.; Didier, Brett T.; Elsethagen, Todd O.; Sun, Lisong; Gurumoorthi, Vidhya; Chase, Jared M.; Li, Jun; Windus, Theresa L.

    2007-05-01

    Basis sets are one of the most important input data for computational models in the chemistry, materials, biology and other science domains that utilize computational quantum mechanics methods. Providing a shared, web accessible environment where researchers can not only download basis sets in their required format, but browse the data, contribute new basis sets, and ultimately curate and manage the data as a community will facilitate growth of this resource and encourage sharing both data and knowledge. We describe the Basis Set Exchange (BSE), a web portal that provides advanced browsing and download capabilities, facilities for contributing basis set data, and an environment that incorporates tools to foster development and interaction of communities. The BSE leverages and enables continued development of the basis set library originally assembled at the Environmental Molecular Sciences Laboratory.

  3. Kaiser-Bessel basis for particle-mesh interpolation

    NASA Astrophysics Data System (ADS)

    Gao, Xingyu; Fang, Jun; Wang, Han

    2017-06-01

    In this work, we introduce the Kaiser-Bessel interpolation basis for the particle-mesh interpolation in the fast Ewald method. A reliable a priori error estimate is developed to measure the accuracy of the force computation in correlated charge systems, and is shown to be effective in optimizing the shape parameter of the Kaiser-Bessel basis in terms of accuracy. By comparing the optimized Kaiser-Bessel basis with the traditional B -spline basis, we demonstrate that the former is more accurate than the latter in part of the working parameter space, say, a relatively small real-space cutoff, a relatively small reciprocal space mesh, and a relatively large truncation of basis. In some cases, the Kaiser-Bessel basis is found to be more than one order of magnitude more accurate.

  4. Kaiser-Bessel basis for particle-mesh interpolation.

    PubMed

    Gao, Xingyu; Fang, Jun; Wang, Han

    2017-06-01

    In this work, we introduce the Kaiser-Bessel interpolation basis for the particle-mesh interpolation in the fast Ewald method. A reliable a priori error estimate is developed to measure the accuracy of the force computation in correlated charge systems, and is shown to be effective in optimizing the shape parameter of the Kaiser-Bessel basis in terms of accuracy. By comparing the optimized Kaiser-Bessel basis with the traditional B-spline basis, we demonstrate that the former is more accurate than the latter in part of the working parameter space, say, a relatively small real-space cutoff, a relatively small reciprocal space mesh, and a relatively large truncation of basis. In some cases, the Kaiser-Bessel basis is found to be more than one order of magnitude more accurate.

  5. 26 CFR 1.1016-10 - Substituted basis.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 11 2010-04-01 2010-04-01 true Substituted basis. 1.1016-10 Section 1.1016-10...) INCOME TAXES Basis Rules of General Application § 1.1016-10 Substituted basis. (a) Whenever it appears... 1016(b), the adjustments indicated in §§ 1.1016-1 to 1.1016-6, inclusive, shall be made after first...

  6. 26 CFR 1.1012-1 - Basis of property.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 11 2012-04-01 2012-04-01 false Basis of property. 1.1012-1 Section 1.1012-1... use the average basis method to compute the basis of the shares of G Company. In 2014, B transfers the... realizes $25.25 ($1.01 * 25) long-term capital gain for the 25 shares acquired on January 8, 2010, and $15...

  7. Differential Forms Basis Functions for Better Conditioned Integral Equations

    SciTech Connect

    Fasenfest, B; White, D; Stowell, M; Rieben, R; Sharpe, R; Madsen, N; Rockway, J D; Champagne, N J; Jandhyala, V; Pingenot, J

    2005-01-13

    Differential forms offer a convenient way to classify physical quantities and set up computational problems. By observing the dimensionality and type of derivatives (divergence,curl,gradient) applied to a quantity, an appropriate differential form can be chosen for that quantity. To use these differential forms in a simulation, the forms must be discretized using basis functions. The 0-form through 2-form basis functions are formed for surfaces. Twisted 1-form and 2-form bases will be presented in this paper. Twisted 1-form (1-forms) basis functions ({Lambda}) are divergence-conforming edge basis functions with units m{sup -1}. They are appropriate for representing vector quantities with continuous normal components, and they belong to the same function space as the commonly used RWG bases [1]. They are used here to formulate the frequency-domain EFIE with Galerkin testing. The 2-form basis functions (f) are scalar basis functions with units m{sup -2} and with no enforced continuity between elements. At lowest order, the 2-form basis functions are similar to pulse basis functions. They are used here to formulate an electrostatic integral equation. It should be noted that the derivative of an n-form differential form basis function is an (n+1)-form, i.e. the derivative of a 1-form basis function is a 2-form. Because the basis functions are constructed such that they have spatial units, the spatial units are removed from the degrees of freedom, leading to a better-conditioned system matrix. In this conference paper, we look at the performance of these differential forms and bases by examining the conditioning of matrix systems for electrostatics and the EFIE. The meshes used were refined across the object to consider the behavior of these basis transforms for elements of different sizes.

  8. 31 CFR 16.1 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Basis and purpose. 16.1 Section 16.1... FRAUD CIVIL REMEDIES ACT OF 1986 § 16.1 Basis and purpose. (a) Basis. This part implements the Program Fraud Civil Remedies Act of 1986, Pub. L. 99-509, sections 6101-6104, 100 Stat. 1874 (October 21,...

  9. 29 CFR 22.1 - Basis and purpose.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Basis and purpose. 22.1 Section 22.1 Labor Office of the Secretary of Labor PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 22.1 Basis and purpose. (a) Basis. This part implements the Program Fraud Civil Remedies Act of 1986, Public Law No. 99-509, sections 6101-6104, 100...

  10. 14 CFR § 1264.100 - Basis and purpose.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Basis and purpose. § 1264.100 Section Â... PROGRAM FRAUD CIVIL PENALTIES ACT OF 1986 § 1264.100 Basis and purpose. (a) Basis. This part implements the Program Fraud Civil Remedies Act of 1986, Pub. L. 99-509, sections 6101-6104, 100 Stat....

  11. Birman—Wenzl—Murakami Algebra and Topological Basis

    NASA Astrophysics Data System (ADS)

    Zhou, Cheng-Cheng; Xue, Kang; Wang, Gang-Cheng; Sun, Chun-Fang; Du, Gui-Jiao

    2012-02-01

    In this paper, we use entangled states to construct 9 × 9-matrix representations of Temperley—Lieb algebra (TLA), then a family of 9 × 9-matrix representations of Birman—Wenzl—Murakami algebra (BWMA) have been presented. Based on which, three topological basis states have been found. And we apply topological basis states to recast nine-dimensional BWMA into its three-dimensional counterpart. Finally, we find the topological basis states are spin singlet states in special case.

  12. 48 CFR 1426.7103-1 - Statutory basis.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Minority Business Reports 1426.7103-1 Statutory basis... qualified minority business enterprises in awarding contracts under the Act and report annually to...

  13. 48 CFR 1426.7102-1 - Statutory basis.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Minority Business Reports 1426.7102-1 Statutory basis...., MBDA) to collect information on acquisition and financial assistance awards to minority businesses,...

  14. 48 CFR 1426.7102-1 - Statutory basis.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Minority Business Reports 1426.7102-1 Statutory basis...., MBDA) to collect information on acquisition and financial assistance awards to minority businesses,...

  15. 48 CFR 1426.7103-1 - Statutory basis.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Minority Business Reports 1426.7103-1 Statutory basis... qualified minority business enterprises in awarding contracts under the Act and report annually to...

  16. 48 CFR 1426.7103-1 - Statutory basis.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Minority Business Reports 1426.7103-1 Statutory basis... qualified minority business enterprises in awarding contracts under the Act and report annually to...

  17. 48 CFR 1426.7103-1 - Statutory basis.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Minority Business Reports 1426.7103-1 Statutory basis... qualified minority business enterprises in awarding contracts under the Act and report annually to...

  18. 48 CFR 1426.7103-1 - Statutory basis.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Minority Business Reports 1426.7103-1 Statutory basis... qualified minority business enterprises in awarding contracts under the Act and report annually to...

  19. 48 CFR 1426.7102-1 - Statutory basis.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Minority Business Reports 1426.7102-1 Statutory basis...., MBDA) to collect information on acquisition and financial assistance awards to minority businesses,...

  20. 48 CFR 1426.7102-1 - Statutory basis.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Minority Business Reports 1426.7102-1 Statutory basis...., MBDA) to collect information on acquisition and financial assistance awards to minority businesses,...

  1. 42 CFR 422.300 - Basis and scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Payments to Medicare Advantage Organizations § 422.300 Basis... for making payments to Medicare Advantage (MA) organizations offering local and regional MA...

  2. 42 CFR 422.300 - Basis and scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Payments to Medicare Advantage Organizations § 422.300 Basis... for making payments to Medicare Advantage (MA) organizations offering local and regional MA...

  3. 7 CFR 810.2003 - Basis of determination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Basis of determination. Each determination of heat-damaged kernels, damaged kernels, material other than... shrunken and broken kernels. Other determinations not specifically provided for under the...

  4. Extension of the basis set of linearized augmented plane wave (LAPW) method by using supplemented tight binding basis functions

    NASA Astrophysics Data System (ADS)

    Nikolaev, A. V.; Lamoen, D.; Partoens, B.

    2016-07-01

    In order to increase the accuracy of the linearized augmented plane wave (LAPW) method, we present a new approach where the plane wave basis function is augmented by two different atomic radial components constructed at two different linearization energies corresponding to two different electron bands (or energy windows). We demonstrate that this case can be reduced to the standard treatment within the LAPW paradigm where the usual basis set is enriched by the basis functions of the tight binding type, which go to zero with zero derivative at the sphere boundary. We show that the task is closely related with the problem of extended core states which is currently solved by applying the LAPW method with local orbitals (LAPW+LO). In comparison with LAPW+LO, the number of supplemented basis functions in our approach is doubled, which opens up a new channel for the extension of the LAPW and LAPW+LO basis sets. The appearance of new supplemented basis functions absent in the LAPW+LO treatment is closely related with the existence of the u ˙ l -component in the canonical LAPW method. We discuss properties of additional tight binding basis functions and apply the extended basis set for computation of electron energy bands of lanthanum (face and body centered structures) and hexagonal close packed lattice of cadmium. We demonstrate that the new treatment gives lower total energies in comparison with both canonical LAPW and LAPW+LO, with the energy difference more pronounced for intermediate and poor LAPW basis sets.

  5. 36 CFR 8.2 - Basis and purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Basis and purpose. 8.2 Section 8.2 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR LABOR STANDARDS APPLICABLE TO EMPLOYEES OF NATIONAL PARK SERVICE CONCESSIONERS § 8.2 Basis and purpose. The public...

  6. Transuranic storage and assay facility interim safety basis

    SciTech Connect

    Porten, D.R., Fluor Daniel Hanford

    1997-02-12

    The Transuranic Waste Storage and Assay Facility (TRUSAF) Interim Safety Basis document provides the authorization basis for the interim operation and restriction on interim operations for the TRUSAF. The TRUSAF ISB demonstrates that the TRUSAF can be operated safely, protecting the workers, the public, and the environment. The previous safety analysis document TRUSAF Hazards Identification and Evaluation (WHC 1987) is superseded by this document.

  7. 42 CFR 416.180 - Basis and scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Intraocular Lenses Furnished by Ambulatory Service Centers § 416.180 Basis and scope. (a) Basis. This subpart... technology intraocular lenses (IOLs) furnished at ambulatory surgical centers (ASCs). (b) Scope. This subpart... is reasonable and related to the cost of acquiring a lens determined by CMS as belonging to a...

  8. 42 CFR 416.180 - Basis and scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Intraocular Lenses Furnished by Ambulatory Service Centers § 416.180 Basis and scope. (a) Basis. This subpart... technology intraocular lenses (IOLs) furnished at ambulatory surgical centers (ASCs). (b) Scope. This subpart... is reasonable and related to the cost of acquiring a lens determined by CMS as belonging to a...

  9. 42 CFR 416.180 - Basis and scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Intraocular Lenses Furnished by Ambulatory Service Centers § 416.180 Basis and scope. (a) Basis. This subpart... technology intraocular lenses (IOLs) furnished at ambulatory surgical centers (ASCs). (b) Scope. This subpart... is reasonable and related to the cost of acquiring a lens determined by CMS as belonging to a...

  10. 7 CFR 75.8 - Basis of service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Basis of service. 75.8 Section 75.8 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... AND CERTIFICATION OF QUALITY OF AGRICULTURAL AND VEGETABLE SEEDS Inspection § 75.8 Basis of service...

  11. 7 CFR 91.15 - Basis of a laboratory service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Basis of a laboratory service. 91.15 Section 91.15..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS SERVICES AND GENERAL INFORMATION Laboratory Service § 91.15 Basis of a laboratory service....

  12. 7 CFR 91.15 - Basis of a laboratory service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Basis of a laboratory service. 91.15 Section 91.15..., Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) COMMODITY LABORATORY TESTING PROGRAMS SERVICES AND GENERAL INFORMATION Laboratory Service § 91.15 Basis of a laboratory service....

  13. 7 CFR 810.1203 - Basis of determination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE OFFICIAL UNITED STATES STANDARDS FOR GRAIN United States Standards for Rye Principles Governing the Application of Standards § 810.1203 Basis... 7 Agriculture 7 2014-01-01 2014-01-01 false Basis of determination. 810.1203 Section...

  14. 7 CFR 810.1203 - Basis of determination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE OFFICIAL UNITED STATES STANDARDS FOR GRAIN United States Standards for Rye Principles Governing the Application of Standards § 810.1203 Basis... 7 Agriculture 7 2013-01-01 2013-01-01 false Basis of determination. 810.1203 Section...

  15. 7 CFR 810.1203 - Basis of determination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE OFFICIAL UNITED STATES STANDARDS FOR GRAIN United States Standards for Rye Principles Governing the Application of Standards § 810.1203 Basis... 7 Agriculture 7 2011-01-01 2011-01-01 false Basis of determination. 810.1203 Section...

  16. 7 CFR 810.1203 - Basis of determination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE OFFICIAL UNITED STATES STANDARDS FOR GRAIN United States Standards for Rye Principles Governing the Application of Standards § 810.1203 Basis... 7 Agriculture 7 2012-01-01 2012-01-01 false Basis of determination. 810.1203 Section...

  17. 7 CFR 54.1005 - Basis of service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Poultry Products § 54.1005 Basis of service. (a) Certification of Sanitary Design and Fabrication... 7 Agriculture 3 2010-01-01 2010-01-01 false Basis of service. 54.1005 Section 54.1005 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE...

  18. 36 CFR 8.2 - Basis and purpose.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 1 2014-07-01 2014-07-01 false Basis and purpose. 8.2 Section 8.2 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR LABOR STANDARDS APPLICABLE TO EMPLOYEES OF NATIONAL PARK SERVICE CONCESSIONERS § 8.2 Basis and purpose. The public...

  19. 36 CFR 8.2 - Basis and purpose.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 36 Parks, Forests, and Public Property 1 2012-07-01 2012-07-01 false Basis and purpose. 8.2 Section 8.2 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR LABOR STANDARDS APPLICABLE TO EMPLOYEES OF NATIONAL PARK SERVICE CONCESSIONERS § 8.2 Basis and purpose. The public...

  20. 36 CFR 8.2 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Basis and purpose. 8.2 Section 8.2 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR LABOR STANDARDS APPLICABLE TO EMPLOYEES OF NATIONAL PARK SERVICE CONCESSIONERS § 8.2 Basis and purpose. The public...

  1. 12 CFR 261b.1 - Basis and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Basis and scope. 261b.1 Section 261b.1 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.1 Basis and scope. This part is issued by the Board of...

  2. 45 CFR 159.100 - Basis and scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Basis and scope. 159.100 Section 159.100 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH CARE REFORM INSURANCE WEB PORTAL § 159.100 Basis and scope. This part establishes provisions governing a...

  3. 47 CFR 64.2001 - Basis and purpose.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false Basis and purpose. 64.2001 Section 64.2001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) MISCELLANEOUS RULES RELATING TO COMMON CARRIERS Customer Proprietary Network Information § 64.2001 Basis and...

  4. 47 CFR 64.2001 - Basis and purpose.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 3 2014-10-01 2014-10-01 false Basis and purpose. 64.2001 Section 64.2001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) MISCELLANEOUS RULES RELATING TO COMMON CARRIERS Customer Proprietary Network Information § 64.2001 Basis and...

  5. 47 CFR 64.2001 - Basis and purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 3 2011-10-01 2011-10-01 false Basis and purpose. 64.2001 Section 64.2001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) MISCELLANEOUS RULES RELATING TO COMMON CARRIERS Customer Proprietary Network Information § 64.2001 Basis and...

  6. 47 CFR 64.2001 - Basis and purpose.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 3 2012-10-01 2012-10-01 false Basis and purpose. 64.2001 Section 64.2001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) MISCELLANEOUS RULES RELATING TO COMMON CARRIERS Customer Proprietary Network Information § 64.2001 Basis and...

  7. 45 CFR 159.100 - Basis and scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Basis and scope. 159.100 Section 159.100 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH CARE REFORM INSURANCE WEB PORTAL § 159.100 Basis and scope. This part establishes provisions governing a...

  8. 47 CFR 64.2001 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Basis and purpose. 64.2001 Section 64.2001 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES (CONTINUED) MISCELLANEOUS RULES RELATING TO COMMON CARRIERS Customer Proprietary Network Information § 64.2001 Basis and purpose...

  9. Improved Algorithm For Finite-Field Normal-Basis Multipliers

    NASA Technical Reports Server (NTRS)

    Wang, C. C.

    1989-01-01

    Improved algorithm reduces complexity of calculations that must precede design of Massey-Omura finite-field normal-basis multipliers, used in error-correcting-code equipment and cryptographic devices. Algorithm represents an extension of development reported in "Algorithm To Design Finite-Field Normal-Basis Multipliers" (NPO-17109), NASA Tech Briefs, Vol. 12, No. 5, page 82.

  10. 42 CFR 431.954 - Basis and scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Improper Payments in Medicaid and CHIP § 431.954 Basis and scope. (a) Basis. The statutory bases for this... or child health assistance under CHIP; and State-specific sample sizes for application of the PERM... improper payments in the fee-for-service (FFS) and managed care components of the Medicaid and CHIP...

  11. 42 CFR 431.954 - Basis and scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Improper Payments in Medicaid and CHIP § 431.954 Basis and scope. (a) Basis. The statutory bases for this... or child health assistance under CHIP; and State-specific sample sizes for application of the PERM... improper payments in the fee-for-service (FFS) and managed care components of the Medicaid and CHIP...

  12. 45 CFR 159.100 - Basis and scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Basis and scope. 159.100 Section 159.100 Public Welfare Department of Health and Human Services REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH CARE REFORM INSURANCE WEB PORTAL § 159.100 Basis and scope. This part establishes provisions governing a Web...

  13. 45 CFR 159.100 - Basis and scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Basis and scope. 159.100 Section 159.100 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH CARE REFORM INSURANCE WEB PORTAL § 159.100 Basis and scope. This part establishes provisions governing a Web...

  14. 45 CFR 159.100 - Basis and scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Basis and scope. 159.100 Section 159.100 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS HEALTH CARE REFORM INSURANCE WEB PORTAL § 159.100 Basis and scope. This part establishes provisions governing a Web...

  15. TECHNICAL BASIS FOR A CANDIDATE BUILDING MATERIALS RADIUM STANDARD

    EPA Science Inventory

    The report summarizes the technical basis for a candidate building materials radium standard. It contains the standard and a summary of the technical basis for the standard. (NOTE: The Florida Radon Research Program (FRRP), sponsored by the Environmental Protection Agency and the...

  16. 40 CFR 72.64 - Statement of basis.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 17 2012-07-01 2012-07-01 false Statement of basis. 72.64 Section 72.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Federal Acid Rain Permit Issuance Procedures § 72.64 Statement of basis. (a) The...

  17. 40 CFR 72.64 - Statement of basis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Statement of basis. 72.64 Section 72.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Federal Acid Rain Permit Issuance Procedures § 72.64 Statement of basis. (a) The...

  18. 40 CFR 72.64 - Statement of basis.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 17 2013-07-01 2013-07-01 false Statement of basis. 72.64 Section 72.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Federal Acid Rain Permit Issuance Procedures § 72.64 Statement of basis. (a) The...

  19. 40 CFR 72.64 - Statement of basis.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 16 2011-07-01 2011-07-01 false Statement of basis. 72.64 Section 72.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Federal Acid Rain Permit Issuance Procedures § 72.64 Statement of basis. (a) The...

  20. 40 CFR 72.64 - Statement of basis.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 17 2014-07-01 2014-07-01 false Statement of basis. 72.64 Section 72.64 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PERMITS REGULATION Federal Acid Rain Permit Issuance Procedures § 72.64 Statement of basis. (a) The...

  1. 42 CFR 416.1 - Basis and scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Basis and scope. 416.1 Section 416.1 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM AMBULATORY SURGICAL SERVICES General Provisions and Definitions § 416.1 Basis and scope....

  2. 30 CFR 206.301 - Value basis for royalty computation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Value basis for royalty computation. 206.301 Section 206.301 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR MINERALS REVENUE MANAGEMENT PRODUCT VALUATION Other Solid Minerals § 206.301 Value basis for royalty computation. (a)...

  3. 47 CFR 4.1 - Scope, basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Scope, basis and purpose. 4.1 Section 4.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL DISRUPTIONS TO COMMUNICATIONS General § 4.1 Scope, basis and purpose. In this part, the Federal Communications Commission is setting forth...

  4. 42 CFR 431.954 - Basis and scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Improper Payments in Medicaid and CHIP § 431.954 Basis and scope. (a) Basis. The statutory bases for this... or child health assistance under CHIP; and State-specific sample sizes for application of the PERM... improper payments in the fee-for-service (FFS) and managed care components of the Medicaid and CHIP...

  5. 42 CFR 431.954 - Basis and scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Improper Payments in Medicaid and CHIP § 431.954 Basis and scope. (a) Basis. The statutory bases for this... or child health assistance under CHIP; and State-specific sample sizes for application of the PERM... improper payments in the fee-for-service (FFS) and managed care components of the Medicaid and CHIP...

  6. 42 CFR 431.954 - Basis and scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Improper Payments in Medicaid and CHIP § 431.954 Basis and scope. (a) Basis. The statutory bases for this... or child health assistance under CHIP; and State-specific sample sizes for application of the PERM... improper payments in the fee-for-service (FFS) and managed care components of the Medicaid and CHIP...

  7. 48 CFR 53.301-1435 - Settlement Proposal (Inventory Basis).

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 2 2011-10-01 2011-10-01 false Settlement Proposal (Inventory Basis). 53.301-1435 Section 53.301-1435 Federal Acquisition Regulations System FEDERAL ACQUISITION... (Inventory Basis). ER09DE97.004 ER09DE97.005 ER09DE97.006 ER09DE97.007...

  8. 48 CFR 53.301-1435 - Settlement Proposal (Inventory Basis).

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Settlement Proposal (Inventory Basis). 53.301-1435 Section 53.301-1435 Federal Acquisition Regulations System FEDERAL ACQUISITION... (Inventory Basis). ER09DE97.004 ER09DE97.005 ER09DE97.006 ER09DE97.007...

  9. 14 CFR 121.162 - ETOPS Type Design Approval Basis.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false ETOPS Type Design Approval Basis. 121.162... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Aircraft Requirements § 121.162 ETOPS Type Design Approval Basis. Except for a passenger-carrying airplane with more than two engines manufactured prior to...

  10. 42 CFR 457.700 - Basis, scope, and applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Strategic Planning, Reporting, and Evaluation § 457.700 Basis, scope, and applicability. (a) Statutory basis... strategic planning, reports, and program budgets; and (2) Section 2108 of the Act, which sets forth... strategic planning, monitoring, reporting and evaluation under title XXI. (c) Applicability....

  11. TECHNICAL BASIS FOR A CANDIDATE BUILDING MATERIALS RADIUM STANDARD

    EPA Science Inventory

    The report summarizes the technical basis for a candidate building materials radium standard. It contains the standard and a summary of the technical basis for the standard. (NOTE: The Florida Radon Research Program (FRRP), sponsored by the Environmental Protection Agency and the...

  12. 26 CFR 1.167(g)-1 - Basis for depreciation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Basis for depreciation. 1.167(g)-1 Section 1.167(g)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Itemized Deductions for Individuals and Corporations § 1.167(g)-1 Basis...

  13. 14 CFR 198.3 - Basis of insurance.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Basis of insurance. 198.3 Section 198.3 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) WAR RISK INSURANCE AVIATION INSURANCE § 198.3 Basis of insurance. (a) Premium insurance may be issued by the FAA...

  14. 14 CFR 198.3 - Basis of insurance.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Basis of insurance. 198.3 Section 198.3 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) WAR RISK INSURANCE AVIATION INSURANCE § 198.3 Basis of insurance. (a) Premium insurance may be issued by the FAA...

  15. 14 CFR 198.3 - Basis of insurance.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Basis of insurance. 198.3 Section 198.3 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) WAR RISK INSURANCE AVIATION INSURANCE § 198.3 Basis of insurance. (a) Premium insurance may be issued by the FAA...

  16. THEORETICAL BASIS FOR THE PRINCIPLE OF SINGLE CELLED ALGAE CULTIVATION,

    DTIC Science & Technology

    The aim of this study is to provide the basis for a mathematical approach to the principle of cultivating chlorella , which will make possible a...biological and design. The mathe matical basis for the amount of chlorella biomass as a function of the duration of its cultivation is presented.

  17. 26 CFR 403.56 - All bids on unit basis.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false All bids on unit basis. 403.56 Section 403.56 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) PROCEDURE AND ADMINISTRATION DISPOSITION OF SEIZED PERSONAL PROPERTY Administrative Sale of Personal Property § 403.56 All bids on unit basis. All competitive bids...

  18. 26 CFR 1.1014-3 - Other basis rules.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ..., whichever is applicable, shall be deemed to be its fair market value. If no estate tax return is required to... trustee sold the real property and invested the proceeds in stock of the Y company at $50 per share. At...) INCOME TAXES Basis Rules of General Application § 1.1014-3 Other basis rules. (a) Fair market value....

  19. 26 CFR 1.1014-3 - Other basis rules.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... for such purpose, whichever is applicable, shall be deemed to be its fair market value. If no estate...'s death, the trustee sold the real property and invested the proceeds in stock of the Y company at...) INCOME TAXES (CONTINUED) Basis Rules of General Application § 1.1014-3 Other basis rules. (a) Fair...

  20. 12 CFR 308.500 - Basis, purpose, and scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... PRACTICE AND PROCEDURE Program Fraud Civil Remedies and Procedures § 308.500 Basis, purpose, and scope. (a) Basis. This subpart implements the Program Fraud Civil Remedies Act, Pub. L. 99-509, sections 6101-6104...) Establishes administrative procedures for imposing civil penalties and assessments against persons who...

  1. 42 CFR 422.200 - Basis and scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Basis and scope. 422.200 Section 422.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Relationships With Providers § 422.200 Basis and scope....

  2. 42 CFR 422.1 - Basis and scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., limitations, and procedures for Medicare services furnished, or paid for, by Medicare Advantage organizations... PROGRAM MEDICARE ADVANTAGE PROGRAM General Provisions § 422.1 Basis and scope. (a) Basis. This part is... enrollment. 1852—Benefits and beneficiary protections. 1853—Payments to Medicare Advantage (MA)...

  3. 42 CFR 422.1 - Basis and scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., limitations, and procedures for Medicare services furnished, or paid for, by Medicare Advantage organizations... PROGRAM MEDICARE ADVANTAGE PROGRAM General Provisions § 422.1 Basis and scope. (a) Basis. This part is... enrollment. 1852—Benefits and beneficiary protections. 1853—Payments to Medicare Advantage (MA)...

  4. 42 CFR 422.200 - Basis and scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Basis and scope. 422.200 Section 422.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Relationships With Providers § 422.200 Basis and scope....

  5. 40 CFR 104.4 - Statement of basis and purpose.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 23 2012-07-01 2012-07-01 false Statement of basis and purpose. 104.4 Section 104.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS PUBLIC HEARINGS ON EFFLUENT STANDARDS FOR TOXIC POLLUTANTS § 104.4 Statement of basis and purpose. Whenever the...

  6. 45 CFR 508.1 - Basis for hearing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Basis for hearing. 508.1 Section 508.1 Public Welfare Regulations Relating to Public Welfare (Continued) FOREIGN CLAIMS SETTLEMENT COMMISSION OF THE... WAR CLAIMS ACT OF 1948, AS AMENDED HEARINGS § 508.1 Basis for hearing. Any claimant whose...

  7. 45 CFR 508.1 - Basis for hearing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Basis for hearing. 508.1 Section 508.1 Public Welfare Regulations Relating to Public Welfare (Continued) FOREIGN CLAIMS SETTLEMENT COMMISSION OF THE... WAR CLAIMS ACT OF 1948, AS AMENDED HEARINGS § 508.1 Basis for hearing. Any claimant whose...

  8. 45 CFR 508.1 - Basis for hearing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Basis for hearing. 508.1 Section 508.1 Public Welfare Regulations Relating to Public Welfare (Continued) FOREIGN CLAIMS SETTLEMENT COMMISSION OF THE... WAR CLAIMS ACT OF 1948, AS AMENDED HEARINGS § 508.1 Basis for hearing. Any claimant whose...

  9. 45 CFR 508.1 - Basis for hearing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Basis for hearing. 508.1 Section 508.1 Public Welfare Regulations Relating to Public Welfare (Continued) FOREIGN CLAIMS SETTLEMENT COMMISSION OF THE... WAR CLAIMS ACT OF 1948, AS AMENDED HEARINGS § 508.1 Basis for hearing. Any claimant whose...

  10. 9 CFR 592.24 - Basis of service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Basis of service. 592.24 Section 592.24 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS General § 592.24 Basis of service. (a)...

  11. 9 CFR 592.24 - Basis of service.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Basis of service. 592.24 Section 592.24 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS General § 592.24 Basis of service. (a)...

  12. 9 CFR 592.24 - Basis of service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Basis of service. 592.24 Section 592.24 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS General § 592.24 Basis of service. (a)...

  13. 9 CFR 592.24 - Basis of service.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Basis of service. 592.24 Section 592.24 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS General § 592.24 Basis of service. (a)...

  14. 9 CFR 592.24 - Basis of service.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Basis of service. 592.24 Section 592.24 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE EGG PRODUCTS INSPECTION VOLUNTARY INSPECTION OF EGG PRODUCTS General § 592.24 Basis of service. (a)...

  15. 34 CFR 81.30 - Basis for recovery of funds.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 1 2011-07-01 2011-07-01 false Basis for recovery of funds. 81.30 Section 81.30 Education Office of the Secretary, Department of Education GENERAL EDUCATION PROVISIONS ACT-ENFORCEMENT Hearings for Recovery of Funds § 81.30 Basis for recovery of funds. (a) Subject to the provisions of §...

  16. 34 CFR 81.30 - Basis for recovery of funds.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Basis for recovery of funds. 81.30 Section 81.30 Education Office of the Secretary, Department of Education GENERAL EDUCATION PROVISIONS ACT-ENFORCEMENT Hearings for Recovery of Funds § 81.30 Basis for recovery of funds. (a) Subject to the provisions of §...

  17. 29 CFR 779.353 - Basis for classification.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 3 2012-07-01 2012-07-01 false Basis for classification. 779.353 Section 779.353 Labor... RETAILERS OF GOODS OR SERVICES Exemptions for Certain Retail or Service Establishments Classification of Sales and Establishments in Certain Industries § 779.353 Basis for classification. The general...

  18. 29 CFR 779.353 - Basis for classification.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 3 2013-07-01 2013-07-01 false Basis for classification. 779.353 Section 779.353 Labor... RETAILERS OF GOODS OR SERVICES Exemptions for Certain Retail or Service Establishments Classification of Sales and Establishments in Certain Industries § 779.353 Basis for classification. The general...

  19. 7 CFR 42.105 - Basis for selection of sample.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 2 2013-01-01 2013-01-01 false Basis for selection of sample. 42.105 Section 42.105... § 42.105 Basis for selection of sample. (a) Identification of lot. Selection of proper samples requires... bags, etc. If such segments or portions noted are of any consequence, the lot may be rejected for...

  20. 7 CFR 42.105 - Basis for selection of sample.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 2 2014-01-01 2014-01-01 false Basis for selection of sample. 42.105 Section 42.105... § 42.105 Basis for selection of sample. (a) Identification of lot. Selection of proper samples requires... bags, etc. If such segments or portions noted are of any consequence, the lot may be rejected for...

  1. 22 CFR 3a.5 - Basis for approval or disapproval.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Basis for approval or disapproval. 3a.5 Section 3a.5 Foreign Relations DEPARTMENT OF STATE GENERAL ACCEPTANCE OF EMPLOYMENT FROM FOREIGN GOVERNMENTS BY MEMBERS OF THE UNIFORMED SERVICES § 3a.5 Basis for approval or disapproval. Decisions by the...

  2. 42 CFR 456.22 - Sample basis evaluation of services.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Sample basis evaluation of services. 456.22 Section 456.22 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... sample basis, of the need for and the quality and timeliness of Medicaid services. ...

  3. 47 CFR 95.1400 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Basis and purpose. 95.1400 Section 95.1400 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Personal Locator Beacons (PLB). § 95.1400 Basis and purpose. The rules in this subpart are...

  4. 47 CFR 95.1400 - Basis and purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Basis and purpose. 95.1400 Section 95.1400 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Personal Locator Beacons (PLB). § 95.1400 Basis and purpose. The rules in this subpart are...

  5. 12 CFR 505.1 - Basis and scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Basis and scope. 505.1 Section 505.1 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY FREEDOM OF INFORMATION ACT § 505.1 Basis... Freedom of Information Act regulations of the Department of the Treasury, 31 CFR part 1, subpart A,...

  6. 12 CFR 505.1 - Basis and scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Basis and scope. 505.1 Section 505.1 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY FREEDOM OF INFORMATION ACT § 505.1 Basis... Freedom of Information Act regulations of the Department of the Treasury, 31 CFR part 1, subpart A,...

  7. No Discrimination on the Basis of Irrelevant Qualifications. Hothead Article

    ERIC Educational Resources Information Center

    Walford, Geoffrey

    2004-01-01

    This paper argues that social justice demands that discrimination on the basis of irrelevant qualifications be made illegal. Just as historically it was seen as 'natural' for discrimination in employment and education to be made on the basis of class, gender, ethnicity, sexuality, disability and age, so (at present) most people see discrimination…

  8. 47 CFR 13.1 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Basis and purpose. 13.1 Section 13.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.1 Basis and... purpose of the rules in this part is to prescribe the manner and conditions under which commercial...

  9. 7 CFR 810.403 - Basis of determination.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... GRAIN United States Standards for Corn Principles Governing the Application of Standards § 810.403 Basis of determination. Each determination of class, damaged kernels, heat-damaged kernels, waxy corn, flint corn, and flint and dent corn is made on the basis of the grain after the removal of the broken...

  10. 7 CFR 810.403 - Basis of determination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... GRAIN United States Standards for Corn Principles Governing the Application of Standards § 810.403 Basis of determination. Each determination of class, damaged kernels, heat-damaged kernels, waxy corn, flint corn, and flint and dent corn is made on the basis of the grain after the removal of the broken...

  11. 7 CFR 810.403 - Basis of determination.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... GRAIN United States Standards for Corn Principles Governing the Application of Standards § 810.403 Basis of determination. Each determination of class, damaged kernels, heat-damaged kernels, waxy corn, flint corn, and flint and dent corn is made on the basis of the grain after the removal of the broken...

  12. 7 CFR 810.403 - Basis of determination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... GRAIN United States Standards for Corn Principles Governing the Application of Standards § 810.403 Basis of determination. Each determination of class, damaged kernels, heat-damaged kernels, waxy corn, flint corn, and flint and dent corn is made on the basis of the grain after the removal of the broken...

  13. 7 CFR 810.403 - Basis of determination.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... GRAIN United States Standards for Corn Principles Governing the Application of Standards § 810.403 Basis of determination. Each determination of class, damaged kernels, heat-damaged kernels, waxy corn, flint corn, and flint and dent corn is made on the basis of the grain after the removal of the broken...

  14. 7 CFR 810.803 - Basis of determination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... made on the basis of the grain as a whole, except the determination of odor is made on either the basis of the grain as a whole or the grain when free from foreign material and fines. Grades and Grade... Agriculture Regulations of the Department of Agriculture (Continued) GRAIN INSPECTION, PACKERS AND...

  15. 40 CFR 35.192 - Basis for allotment.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Basis for allotment. 35.192 Section 35.192 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE... 1443(b)) § 35.192 Basis for allotment. The Administrator allots funds for grants to support State's...

  16. 40 CFR 35.192 - Basis for allotment.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Basis for allotment. 35.192 Section 35.192 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE... 1443(b)) § 35.192 Basis for allotment. The Administrator allots funds for grants to support State's...

  17. 40 CFR 35.192 - Basis for allotment.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Basis for allotment. 35.192 Section 35.192 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE... 1443(b)) § 35.192 Basis for allotment. The Administrator allots funds for grants to support State's...

  18. 40 CFR 35.192 - Basis for allotment.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Basis for allotment. 35.192 Section 35.192 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE... 1443(b)) § 35.192 Basis for allotment. The Administrator allots funds for grants to support State's...

  19. Random phase approximation in a deformed Hartree-Fock basis

    SciTech Connect

    Gering, M.Z.I.; Heiss, W.D.

    1984-03-01

    The validity of the random phase approximation in a deformed Hartree-Fock basis is investigated in a soluble model. There is strong evidence that the random phase approximation reproduces well the vibrational excitations of the system. Within the framework of the Green's function technique, the significance of the deformed single particle basis is established.

  20. 9 CFR 590.130 - Basis of billing plants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Basis of billing plants. 590.130... of Service § 590.130 Basis of billing plants. Overtime and/or holiday services shall be billed to the... are payable upon receipt and become delinquent 30 days from date of billing. Overtime or...

  1. 42 CFR 416.1 - Basis and scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Basis and scope. 416.1 Section 416.1 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM AMBULATORY SURGICAL SERVICES General Provisions and Definitions § 416.1 Basis and scope. (a...

  2. 42 CFR 433.135 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Basis and purpose. 433.135 Section 433.135 Public...) MEDICAL ASSISTANCE PROGRAMS STATE FISCAL ADMINISTRATION Third Party Liability § 433.135 Basis and purpose... to pay for services provided under the plan; (b) Assignment to the State of an individual's rights to...

  3. 42 CFR 403.200 - Basis and scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Basis and scope. 403.200 Section 403.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Medicare Supplemental Policies § 403.200 Basis and scope. (a...

  4. 42 CFR 403.200 - Basis and scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 2 2013-10-01 2013-10-01 false Basis and scope. 403.200 Section 403.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Medicare Supplemental Policies § 403.200 Basis and scope. (a...

  5. 42 CFR 403.200 - Basis and scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Basis and scope. 403.200 Section 403.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Medicare Supplemental Policies § 403.200 Basis and scope. (a...

  6. 42 CFR 403.200 - Basis and scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 2 2014-10-01 2014-10-01 false Basis and scope. 403.200 Section 403.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Medicare Supplemental Policies § 403.200 Basis and scope. (a...

  7. 42 CFR 403.200 - Basis and scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Basis and scope. 403.200 Section 403.200 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL PROVISIONS SPECIAL PROGRAMS AND PROJECTS Medicare Supplemental Policies § 403.200 Basis and scope. (a...

  8. Transuranic waste storage and assay facility (TRUSAF) interim safety basis

    SciTech Connect

    Gibson, K.D.

    1995-09-01

    The TRUSAF ISB is based upon current facility configuration and procedures. The purpose of the document is to provide the basis for interim operation or restrictions on interim operations and the authorization basis for the TRUSAF at the Hanford Site. The previous safety analysis document TRUSAF hazards Identification and Evaluation (WHC 1977) is superseded by this document.

  9. 47 CFR 95.1400 - Basis and purpose.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Basis and purpose. 95.1400 Section 95.1400 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Personal Locator Beacons (PLB) § 95.1400 Basis and purpose. The rules in this subpart are...

  10. 47 CFR 95.1400 - Basis and purpose.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Basis and purpose. 95.1400 Section 95.1400 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Personal Locator Beacons (PLB) § 95.1400 Basis and purpose. The rules in this subpart are...

  11. 47 CFR 95.1400 - Basis and purpose.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Basis and purpose. 95.1400 Section 95.1400 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES PERSONAL RADIO SERVICES Personal Locator Beacons (PLB) § 95.1400 Basis and purpose. The rules in this subpart are...

  12. 28 CFR 76.3 - Basis for civil penalty.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Basis for civil penalty. 76.3 Section 76... CIVIL PENALTIES FOR POSSESSION OF CERTAIN CONTROLLED SUBSTANCES § 76.3 Basis for civil penalty. (a) Any....C. 844a shall be liable to the United States for a civil penalty in an amount of not to exceed...

  13. 28 CFR 76.3 - Basis for civil penalty.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Basis for civil penalty. 76.3 Section 76... CIVIL PENALTIES FOR POSSESSION OF CERTAIN CONTROLLED SUBSTANCES § 76.3 Basis for civil penalty. (a) Any....C. 844a shall be liable to the United States for a civil penalty in an amount of not to exceed...

  14. 48 CFR 245.7302-4 - Basis for sale.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Basis for sale. 245.7302-4..., DEPARTMENT OF DEFENSE CONTRACT MANAGEMENT GOVERNMENT PROPERTY Sale of Surplus Contractor Inventory 245.7302-4 Basis for sale. (a) Unit price basis—requires the offeror to state the bid price in terms of...

  15. 7 CFR 56.4 - Basis of grading service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) VOLUNTARY GRADING OF SHELL EGGS Grading of Shell Eggs General § 56.4 Basis of grading service. (a) Any grading service in... the basis of the “United States Standards, Grades, and Weight Classes for Egg Shells.” However...

  16. 7 CFR 56.4 - Basis of grading service.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) VOLUNTARY GRADING OF SHELL EGGS Grading of Shell Eggs General § 56.4 Basis of grading service. (a) Any grading service in... the basis of the “United States Standards, Grades, and Weight Classes for Egg Shells.” However...

  17. 7 CFR 56.4 - Basis of grading service.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) VOLUNTARY GRADING OF SHELL EGGS Grading of Shell Eggs General § 56.4 Basis of grading service. (a) Any grading service in... the basis of the “United States Standards, Grades, and Weight Classes for Egg Shells.” However...

  18. 7 CFR 56.4 - Basis of grading service.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) VOLUNTARY GRADING OF SHELL EGGS Grading of Shell Eggs General § 56.4 Basis of grading service. (a) Any grading service in... the basis of the “United States Standards, Grades, and Weight Classes for Egg Shells.” However...

  19. 7 CFR 56.4 - Basis of grading service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURAL MARKETING ACT OF 1946 AND THE EGG PRODUCTS INSPECTION ACT (CONTINUED) VOLUNTARY GRADING OF SHELL EGGS Grading of Shell Eggs General § 56.4 Basis of grading service. (a) Any grading service in... the basis of the “United States Standards, Grades, and Weight Classes for Egg Shells.” However...

  20. 42 CFR 483.350 - Basis and scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Inpatient Psychiatric Services for Individuals Under Age 21 § 483.350 Basis and scope. (a) Statutory basis... psychiatric services for children under the age of 21 as defined by sections 1905(a)(16) and (h) of the Act... to individuals under age 21. ...

  1. 42 CFR 483.350 - Basis and scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Inpatient Psychiatric Services for Individuals Under Age 21 § 483.350 Basis and scope. (a) Statutory basis... psychiatric services for children under the age of 21 as defined by sections 1905(a)(16) and (h) of the Act... to individuals under age 21. ...

  2. 42 CFR 483.350 - Basis and scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Inpatient Psychiatric Services for Individuals Under Age 21 § 483.350 Basis and scope. (a) Statutory basis... psychiatric services for children under the age of 21 as defined by sections 1905(a)(16) and (h) of the Act... to individuals under age 21. ...

  3. 42 CFR 483.350 - Basis and scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Inpatient Psychiatric Services for Individuals Under Age 21 § 483.350 Basis and scope. (a) Statutory basis... psychiatric services for children under the age of 21 as defined by sections 1905(a)(16) and (h) of the Act... to individuals under age 21. ...

  4. 42 CFR 483.350 - Basis and scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Inpatient Psychiatric Services for Individuals Under Age 21 § 483.350 Basis and scope. (a) Statutory basis... psychiatric services for children under the age of 21 as defined by sections 1905(a)(16) and (h) of the Act... to individuals under age 21. ...

  5. 26 CFR 1.362-1 - Basis to corporations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Basis to corporations. 1.362-1 Section 1.362-1...) INCOME TAXES Effects on Corporation § 1.362-1 Basis to corporations. (a) In general. Section 362 provides, as a general rule, that if property was acquired on or after June 22, 1954, by a corporation (1)...

  6. 42 CFR 403.700 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Basis and purpose. 403.700 Section 403.700 Public... PROVISIONS SPECIAL PROGRAMS AND PROJECTS Religious Nonmedical Health Care Institutions-Benefits, Conditions of Participation, and Payment § 403.700 Basis and purpose. This subpart implements sections 1821...

  7. 31 CFR 150.4 - Calculation of assessment basis.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Calculation of assessment basis. 150.4 Section 150.4 Money and Finance: Treasury Regulations Relating to Money and Finance MONETARY OFFICES, DEPARTMENT OF THE TREASURY FINANCIAL RESEARCH FUND § 150.4 Calculation of assessment basis....

  8. 22 CFR 40.6 - Basis for refusal.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Basis for refusal. 40.6 Section 40.6 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING TO BOTH NONIMMIGRANTS AND IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED General Provisions § 40.6 Basis for refusal. A visa can be...

  9. 22 CFR 40.6 - Basis for refusal.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Basis for refusal. 40.6 Section 40.6 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING TO BOTH NONIMMIGRANTS AND IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED General Provisions § 40.6 Basis for refusal. A visa can be...

  10. 22 CFR 40.6 - Basis for refusal.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Basis for refusal. 40.6 Section 40.6 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING TO BOTH NONIMMIGRANTS AND IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED General Provisions § 40.6 Basis for refusal. A visa can be...

  11. 22 CFR 40.6 - Basis for refusal.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Basis for refusal. 40.6 Section 40.6 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING TO BOTH NONIMMIGRANTS AND IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED General Provisions § 40.6 Basis for refusal. A visa can be...

  12. 22 CFR 40.6 - Basis for refusal.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Basis for refusal. 40.6 Section 40.6 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING TO BOTH NONIMMIGRANTS AND IMMIGRANTS UNDER THE IMMIGRATION AND NATIONALITY ACT, AS AMENDED General Provisions § 40.6 Basis for refusal. A visa can be...

  13. 42 CFR 416.180 - Basis and scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Lenses Furnished by Ambulatory Service Centers § 416.180 Basis and scope. (a) Basis. This subpart... technology intraocular lenses (IOLs) furnished at ambulatory surgical centers (ASCs). (b) Scope. This subpart... is reasonable and related to the cost of acquiring a lens determined by CMS as belonging to a...

  14. 10 CFR 110.80 - Basis for hearings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Basis for hearings. 110.80 Section 110.80 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Public Participation Procedures Concerning License Applications § 110.80 Basis for hearings. The procedures in this part...

  15. 7 CFR 810.103 - Basis of determination.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... GRAIN General Provisions Principles Governing the Application of Standards § 810.103 Basis of determination. (a) Distinctly low quality. The determination of distinctly low quality is made on the basis of... representative sample and/or the sample as a whole. (b) Certain quality determinations. Each determination of...

  16. 7 CFR 810.103 - Basis of determination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... GRAIN General Provisions Principles Governing the Application of Standards § 810.103 Basis of determination. (a) Distinctly low quality. The determination of distinctly low quality is made on the basis of... representative sample and/or the sample as a whole. (b) Certain quality determinations. Each determination of...

  17. 42 CFR 457.300 - Basis, scope, and applicability.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Basis, scope, and applicability. 457.300 Section 457.300 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... State Plan Requirements: Eligibility, Screening, Applications, and Enrollment § 457.300 Basis,...

  18. 42 CFR 431.300 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Basis and purpose. 431.300 Section 431.300 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... Applicants and Recipients § 431.300 Basis and purpose. (a) Section 1902(a)(7) of the Act requires that...

  19. 42 CFR 441.300 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Basis and purpose. 441.300 Section 441.300 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED... Community-Based Services: Waiver Requirements § 441.300 Basis and purpose. Section 1915(c) of the...

  20. Basis Functions in Image Reconstruction From Projections: A Tutorial Introduction

    NASA Astrophysics Data System (ADS)

    Herman, Gabor T.

    2015-11-01

    The series expansion approaches to image reconstruction from projections assume that the object to be reconstructed can be represented as a linear combination of fixed basis functions and the task of the reconstruction algorithm is to estimate the coefficients in such a linear combination based on the measured projection data. It is demonstrated that using spherically symmetric basis functions (blobs), instead of ones based on the more traditional pixels, yields superior reconstructions of medically relevant objects. The demonstration uses simulated computerized tomography projection data of head cross-sections and the series expansion method ART for the reconstruction. In addition to showing the results of one anecdotal example, the relative efficacy of using pixel and blob basis functions in image reconstruction from projections is also evaluated using a statistical hypothesis testing based task oriented comparison methodology. The superiority of the efficacy of blob basis functions over that of pixel basis function is found to be statistically significant.

  1. Exploring continuum structures with a pseudo-state basis

    SciTech Connect

    Lay, J. A.; Moro, A. M.; Arias, J. M.; Gomez-Camacho, J.

    2010-08-15

    The ability of a recently developed square-integrable discrete basis to represent the properties of the continuum of a two-body system is investigated. The basis is obtained performing a simple analytic local scale transformation to the harmonic oscillator basis. Scattering phase-shifts and the electric transition probabilities B(E1) and B(E2) have been evaluated for several potentials using the proposed basis. Both quantities are found to be in excellent agreement with the exact values calculated from the true scattering states. The basis has been applied to describe the projectile continuum in the {sup 6}He scattering by {sup 12}C and {sup 208}Pb targets at 240 MeV/nucleon and the {sup 11}Be scattering by {sup 12}C at 67 MeV/nucleon. The calculated breakup differential cross sections are found to be in very good agreement with the available experimental data for these reactions.

  2. Emergence of a measurement basis in atom-photon scattering.

    PubMed

    Glickman, Yinnon; Kotler, Shlomi; Akerman, Nitzan; Ozeri, Roee

    2013-03-08

    After measurement, a wave-function is postulated to collapse on a predetermined set of states--the measurement basis. Using quantum process tomography, we show how a measurement basis emerges in the evolution of the electronic spin of a single trapped atomic ion after spontaneous photon scattering and detection. This basis is determined by the excitation laser polarization and the direction along which the photon was detected. Quantum tomography of the combined spin-photon state reveals that although photon scattering entangles all superpositions of the measurement-basis states with the scattered photon polarization, the measurement-basis states themselves remain classically correlated with it. Our findings shed light on the process of quantum measurement in atom-photon interactions.

  3. Basis set dependence of the doubly hybrid XYG3 functional

    NASA Astrophysics Data System (ADS)

    Zhang, Igor Ying; Luo, Yi; Xu, Xin

    2010-09-01

    In the present study, we investigated the basis set dependence of XYG3, a newly developed doubly hybrid functional [Y. Zhang, X. Xu, and W. A. Goddard III, Proc. Natl. Acad. Sci. U.S.A. 106, 4963 (2009)], in prediction of (1) heats of formation (HOFs), (2) bond dissociation enthalpies (BDEs), (3) reaction barrier heights (RBHs), and (4) nonbonded interactions (NBIs). We used basis sets of triple-zeta quality starting from 6-311+G(d,p) with increasing completeness of the polarization functions to the largest Pople-type basis set 6-311++G(3df,3pd) and found that there was a continued improvement with larger basis sets. We showed that while HOF predictions were prone to basis set deficiencies, the basis set dependences in calculating BDEs, RBHs, and NBIs were mild. All of them converged fast with the increase of basis set size. We extended XYG3 to propose the XYG3o functional which was specifically optimized for a particular basis set in order to enhance its performance when using basis set of moderate size. With the 6-311+G(2df,p) basis set, XYG3o led to MADs of 2.56 kcal/mol for HOFs of the G3/99 set, 1.17 kcal/mol for BDEs of the BDE92/07 set, 1.11 kcal/mol for RBHs of the NHTBH38/04 and HTBH38/04 sets, and 0.40 kcal/mol for NBIs of the NCIE31/05 set, being comparable to those obtained by using XYG3/6-311++G(3df,3pd).

  4. Auxiliary Basis Sets for Density-Fitted MP2 Calculations: Correlation-Consistent Basis Sets for the 4d Elements.

    PubMed

    Hill, J Grant; Platts, James A

    2009-03-10

    Auxiliary basis sets for use in density fitting second-order Møller-Plesset perturbation theory and other correlated ab initio methods have been developed for the 4d transition metal elements Y-Tc and Rh-Pd (sets for Ru, Ag, and Cd are already available), to be used in conjunction with the correlation consistent basis sets with pseudopotentials cc-pVnZ-PP and aug-cc-pVnZ-PP. Correlation energy calculations for a test set of small- to medium-sized transition metal complexes encompassing a variety of oxidation states show that the error in using these auxiliary basis sets is around 3-4 orders of magnitude smaller than the error due to orbital basis set size. The effect of truncating the auxiliary basis sets to remove higher angular momentum functions is also considered.

  5. A new basis set for molecular bending degrees of freedom

    NASA Astrophysics Data System (ADS)

    Jutier, Laurent

    2010-07-01

    We present a new basis set as an alternative to Legendre polynomials for the variational treatment of bending vibrational degrees of freedom in order to highly reduce the number of basis functions. This basis set is inspired from the harmonic oscillator eigenfunctions but is defined for a bending angle in the range θ ɛ[0:π]. The aim is to bring the basis functions closer to the final (ro)vibronic wave functions nature. Our methodology is extended to complicated potential energy surfaces, such as quasilinearity or multiequilibrium geometries, by using several free parameters in the basis functions. These parameters allow several density maxima, linear or not, around which the basis functions will be mainly located. Divergences at linearity in integral computations are resolved as generalized Legendre polynomials. All integral computations required for the evaluation of molecular Hamiltonian matrix elements are given for both discrete variable representation and finite basis representation. Convergence tests for the low energy vibronic states of HCCH++, HCCH+, and HCCS are presented.

  6. Localized basis sets for unbound electrons in nanoelectronics.

    PubMed

    Soriano, D; Jacob, D; Palacios, J J

    2008-02-21

    It is shown how unbound electron wave functions can be expanded in a suitably chosen localized basis sets for any desired range of energies. In particular, we focus on the use of Gaussian basis sets, commonly used in first-principles codes. The possible usefulness of these basis sets in a first-principles description of field emission or scanning tunneling microscopy at large bias is illustrated by studying a simpler related phenomenon: The lifetime of an electron in a H atom subjected to a strong electric field.

  7. Normal basis of finite field GF(2 super m)

    NASA Technical Reports Server (NTRS)

    Pei, D. Y.; Wang, C. C.; Omura, J. K.

    1986-01-01

    Massey and Omura (1981) recently developed a new multiplication algorithm for Galois fields based on the normal basis representation. This algorithm shows a much simpler way to perform multiplication in finite field than the conventional method. The necessary and sufficient conditions are presented for an element to generate a normal basis in the field GF(2 super m), where m = 2 super k p super n and p super n has two as a primitive root. This result provides a way to find a normal basis in the field.

  8. 47 CFR 1.1301 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... National Environmental Policy Act of 1969 § 1.1301 Basis and purpose. The provisions of this subpart implement Subchapter I of the National Environmental Policy Act of 1969, as amended, 42 U.S.C. 4321-4335....

  9. 42 CFR 431.700 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Nursing Home Administrators § 431.700 Basis and purpose. This subpart implements sections 1903(a)(29) and 1908 of the Act which require that the State plan include a State program for licensing nursing home...

  10. 42 CFR 431.700 - Basis and purpose.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Nursing Home Administrators § 431.700 Basis and purpose. This subpart implements sections 1903(a)(29) and 1908 of the Act which require that the State plan include a State program for licensing nursing home...

  11. 42 CFR 431.700 - Basis and purpose.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Nursing Home Administrators § 431.700 Basis and purpose. This subpart implements sections 1903(a)(29) and 1908 of the Act which require that the State plan include a State program for licensing nursing home...

  12. 42 CFR 431.700 - Basis and purpose.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Nursing Home Administrators § 431.700 Basis and purpose. This subpart implements sections 1903(a)(29) and 1908 of the Act which require that the State plan include a State program for licensing nursing home...

  13. 38 CFR 17.42 - Examinations on an outpatient basis.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... MEDICAL Examinations and Observation and Examination § 17.42 Examinations on an outpatient basis. Physical... care and to the same categories of persons for whom hospitalization for observation and examination may...

  14. A generalized algorithm to design finite field normal basis multipliers

    NASA Technical Reports Server (NTRS)

    Wang, C. C.

    1986-01-01

    Finite field arithmetic logic is central in the implementation of some error-correcting coders and some cryptographic devices. There is a need for good multiplication algorithms which can be easily realized. Massey and Omura recently developed a new multiplication algorithm for finite fields based on a normal basis representation. Using the normal basis representation, the design of the finite field multiplier is simple and regular. The fundamental design of the Massey-Omura multiplier is based on a design of a product function. In this article, a generalized algorithm to locate a normal basis in a field is first presented. Using this normal basis, an algorithm to construct the product function is then developed. This design does not depend on particular characteristics of the generator polynomial of the field.

  15. Basis And Application Of The CARES/LIFE Computer Program

    NASA Technical Reports Server (NTRS)

    Nemeth, Noel N.; Janosik, Lesley A.; Gyekenyesi, John P.; Powers, Lynn M.

    1996-01-01

    Report discusses physical and mathematical basis of Ceramics Analysis and Reliability Evaluation of Structures LIFE prediction (CARES/LIFE) computer program, described in "Program for Evaluation of Reliability of Ceramic Parts" (LEW-16018).

  16. 7 CFR 868.253 - Basis of determination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... FOR CERTAIN AGRICULTURAL COMMODITIES United States Standards for Brown Rice for Processing Principles... brown rice for processing shall be on the basis of the brown rice for processing after it has been...

  17. Decoy-state quantum key distribution with biased basis choice

    PubMed Central

    Wei, Zhengchao; Wang, Weilong; Zhang, Zhen; Gao, Ming; Ma, Zhi; Ma, Xiongfeng

    2013-01-01

    We propose a quantum key distribution scheme that combines a biased basis choice with the decoy-state method. In this scheme, Alice sends all signal states in the Z basis and decoy states in the X and Z basis with certain probabilities, and Bob measures received pulses with optimal basis choice. This scheme simplifies the system and reduces the random number consumption. From the simulation result taking into account of statistical fluctuations, we find that in a typical experimental setup, the proposed scheme can increase the key rate by at least 45% comparing to the standard decoy-state scheme. In the postprocessing, we also apply a rigorous method to upper bound the phase error rate of the single-photon components of signal states. PMID:23948999

  18. 42 CFR 432.1 - Basis and purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... system of State personnel administration and training and use of subprofessional staff and volunteers in...) MEDICAL ASSISTANCE PROGRAMS STATE PERSONNEL ADMINISTRATION General Provisions § 432.1 Basis and purpose... State training programs for all staff. ...

  19. 42 CFR 433.110 - Basis, purpose, and applicability.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... and Information Retrieval Systems § 433.110 Basis, purpose, and applicability. (a) This subpart... information retrieval systems and for the operation of certain systems. Additional HHS regulations and CMS... conditions on mechanized claims processing and information retrieval systems (including...

  20. 42 CFR 433.110 - Basis, purpose, and applicability.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... and Information Retrieval Systems § 433.110 Basis, purpose, and applicability. (a) This subpart... information retrieval systems and for the operation of certain systems. Additional HHS regulations and CMS... conditions on mechanized claims processing and information retrieval systems (including...