LEAP into the Pfizer Global Virtual Library (PGVL) space: creation of readily synthesizable design ideas automatically.

PubMed

Hu, Qiyue; Peng, Zhengwei; Kostrowicki, Jaroslav; Kuki, Atsuo

2011-01-01

Pfizer Global Virtual Library (PGVL) of 10(13) readily synthesizable molecules offers a tremendous opportunity for lead optimization and scaffold hopping in drug discovery projects. However, mining into a chemical space of this size presents a challenge for the concomitant design informatics due to the fact that standard molecular similarity searches against a collection of explicit molecules cannot be utilized, since no chemical information system could create and manage more than 10(8) explicit molecules. Nevertheless, by accepting a tolerable level of false negatives in search results, we were able to bypass the need for full 10(13) enumeration and enabled the efficient similarity search and retrieval into this huge chemical space for practical usage by medicinal chemists. In this report, two search methods (LEAP1 and LEAP2) are presented. The first method uses PGVL reaction knowledge to disassemble the incoming search query molecule into a set of reactants and then uses reactant-level similarities into actual available starting materials to focus on a much smaller sub-region of the full virtual library compound space. This sub-region is then explicitly enumerated and searched via a standard similarity method using the original query molecule. The second method uses a fuzzy mapping onto candidate reactions and does not require exact disassembly of the incoming query molecule. Instead Basis Products (or capped reactants) are mapped into the query molecule and the resultant asymmetric similarity scores are used to prioritize the corresponding reactions and reactant sets. All sets of Basis Products are inherently indexed to specific reactions and specific starting materials. This again allows focusing on a much smaller sub-region for explicit enumeration and subsequent standard product-level similarity search. A set of validation studies were conducted. The results have shown that the level of false negatives for the disassembly-based method is acceptable when the query molecule can be recognized for exact disassembly, and the fuzzy reaction mapping method based on Basis Products has an even better performance in terms of lower false-negative rate because it is not limited by the requirement that the query molecule needs to be recognized by any disassembly algorithm. Both search methods have been implemented and accessed through a powerful desktop molecular design tool (see ref. (33) for details). The chapter will end with a comparison of published search methods against large virtual chemical space.

The Cost of Quality--Its Application to Libraries.

ERIC Educational Resources Information Center

Franklin, Brinley

1994-01-01

Examines the conceptual basis for the cost of quality and its application to libraries. The framework for analysis of this conceptual basis includes definitions of the cost of quality; a brief historical review of the cost of quality; and the application of quality cost to libraries, including an explanation of how quality costs respond to quality…

Planning & Urban Affairs Library Manual.

ERIC Educational Resources Information Center

Knobbe, Mary L., Ed.; Lessel, Janice W., Ed.

Written especially for persons without a library degree who are operating a small urban study or planning agency library on a part-time basis. Subjects covered are: (1) library function and staff function, duties and training; (2) physical layout and equipment of library; (3) establishing and maintaining the library; (4) library administration;…

National Library Associations and Their Impact on Library Legislation: An International Survey.

ERIC Educational Resources Information Center

Fang, Josephine Riss

Librarians may most effectively promote library legislation needed to further the goals of libraries and library service through legislative lobbying activities. The legal basis for library legislation exists in the undisputed fact that libraries are agencies of learning and therefore merit the same legislative attention as schools. The most basic…

University Libraries and Other General Research Libraries Section. General Research Libraries Division. Papers.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

Papers on network activity among university and other general research libraries and information centers presented at the 1982 International Federation of Library Associations (IFLA) conference include: (1) "The Principles of the Relationship Between National and University Library Collections as a Basis for a Network" by K. W. Humphreys (United…

Impact of a Graduate Entry Programme on a medical school library service.

PubMed

Martin, Sam

2003-03-01

The aim of this study was to compare the use of library facilities by first year undergraduate medical students and Graduate Entry Programme students (GEP). More specifically it tried to determine which library services (if any) were more frequently used by GEP so that this could be taken into account in future Information Services planning. A questionnaire on the use of Library and Information Services was posted to all first year GEP students and undergraduates on the 5-year course. In addition, user statistics of library entry and borrowing were collated from gate readings and the library Unicorn management system. Overall, GEP students were found to make a greater daily/weekly use of library facilities than undergraduates on the 5-year course. The facilities most used by both sets of students were essential texts, e-mail, PCs and study facilities. Computer Aided Learning packages, journals and video facilities were least used. However, on a daily/weekly basis GEP students made 74% more use of journals (P < 0.01), 59% more use of e-journals (P < 0.05), 36% more use photocopiers (P < 0.05), 42% more use of printers (P < 0.05), 56% more use of the library catalogue (P < 0.05) and 50% more use of databases (P < 0.05). This difference in use should be taken into account by LIS providers as there is expected to be an increase in fast-track graduate courses offered by medical schools throughout the UK.

Multidimensional signaling via wavelet packets

NASA Astrophysics Data System (ADS)

Lindsey, Alan R.

1995-04-01

This work presents a generalized signaling strategy for orthogonally multiplexed communication. Wavelet packet modulation (WPM) employs the basis functions from an arbitrary pruning of a full dyadic tree structured filter bank as orthogonal pulse shapes for conventional QAM symbols. The multi-scale modulation (MSM) and M-band wavelet modulation (MWM) schemes which have been recently introduced are handled as special cases, with the added benefit of an entire library of potentially superior sets of basis functions. The figures of merit are derived and it is shown that the power spectral density is equivalent to that for QAM (in fact, QAM is another special case) and hence directly applicable in existing systems employing this standard modulation. Two key advantages of this method are increased flexibility in time-frequency partitioning and an efficient all-digital filter bank implementation, making the WPM scheme more robust to a larger set of interferences (both temporal and sinusoidal) and computationally attractive as well.

THE COMMUNITY COLLEGE LIBRARY, AN APPRAISAL OF CURRENT PRACTICE.

ERIC Educational Resources Information Center

WHEELER, HELEN RIPPIER

THE BASIS FOR A QUESTIONNAIRE SENT TO LIBRARY DIRECTORS IN 198 PUBLIC JUNIOR COLLEGES WAS A LIST OF 10 CRITERIA--(1) THE LIBRARY PROGRAM REFLECTS THE COLLEGE CURRICULUM, OBJECTIVES, AND FUNCTIONS. (2) CONTINUOUS EVALUATION OF THE LIBRARY IS PROVIDED BY APPROPRIATE TECHNIQUES AND MEASURES. (3) THE LIBRARY FACILITATES THE FACULTY'S RESEARCH AND…

Nuclide radioactive decay data uncertainties library

NASA Astrophysics Data System (ADS)

Barabanova, D. S.; Zherdev, G. M.

2017-01-01

The results of the developing the library of uncertainties of radioactive decay data in the ABBN data library format are described. Different evaluations of uncertainties were compared and their effects on the results of calculations of residual energy release were determined using the test problems and experiment. Tables were generated in the ABBN format with the data obtained on the basis of libraries in ENDF-6 format. 3821 isotopes from the ENDF/B-7 data library, 3852 isotopes from the JEFF-3.11 data library and 1264 isotopes from the JENDL-4.0 data library were processed. It was revealed that the differences in the evaluations accepted in different decay data libraries are not so big, although they sometimes exceed the uncertainties assigned to the data in the ENDF/B-7 and JEFF-3.11 libraries, which as a rule, they agree with each other. On the basis of developed method it is supposed to create a library of data uncertainties for radioactive decay within the constant data system in FSUE RFNC-VNIIEF with its further connection with CRYSTAL module.

The NASA Ames PAH IR Spectroscopic Database: Computational Version 3.00 with Updated Content and the Introduction of Multiple Scaling Factors

NASA Astrophysics Data System (ADS)

Bauschlicher, Charles W., Jr.; Ricca, A.; Boersma, C.; Allamandola, L. J.

2018-02-01

Version 3.00 of the library of computed spectra in the NASA Ames PAH IR Spectroscopic Database (PAHdb) is described. Version 3.00 introduces the use of multiple scale factors, instead of the single scaling factor used previously, to align the theoretical harmonic frequencies with the experimental fundamentals. The use of multiple scale factors permits the use of a variety of basis sets; this allows new PAH species to be included in the database, such as those containing oxygen, and yields an improved treatment of strained species and those containing nitrogen. In addition, the computed spectra of 2439 new PAH species have been added. The impact of these changes on the analysis of an astronomical spectrum through database-fitting is considered and compared with a fit using Version 2.00 of the library of computed spectra. Finally, astronomical constraints are defined for the PAH spectral libraries in PAHdb.

The Recognition of Depreciation of Library Materials.

ERIC Educational Resources Information Center

Carpenter, Michael; Millican, Rita

1991-01-01

Discussion of the depreciation of assets for nonprofit organizations focuses on a study conducted at the Louisiana State University Law Library to determine the cost basis for depreciation of library materials. Determining the useful life of the library materials is described and various methods of depreciation are explained. (five references)…

Past into Future: Capturing Library Expertise in a Virtual Library.

ERIC Educational Resources Information Center

Daniels, Wayne; Scardellato, Kathy

1999-01-01

Reports on an initiative by the Toronto Public Library to create the "Virtual Reference Library" (VRL). Describes the first service to be offered, a Dewey application called "Science Net." Discusses the VRL and its precursor, objectives, basis for its funding, technical aspects, progress to date and future direction. (AEF)

Intelligent Libraries and Apomediators: Distinguishing between Library 3.0 and Library 2.0

ERIC Educational Resources Information Center

Kwanya, Tom; Stilwell, Christine; Underwood, Peter G.

2013-01-01

Using the "point oh" naming system for developments in librarianship is attracting debate about its appropriateness, basis and syntax and the meaning and potential of Library 2.0. Now a new term, Library 3.0, has emerged. Is there is any significant difference between the two models? Using documentary analysis to explore the terms, the…

The role of the medical departmental library.

PubMed Central

Moran, B

1996-01-01

At most academic medical institutions, the first level of library service is provided by health sciences or medical school libraries. For many medical departments, however, these services are also provided by a second-level library, the departmental library. These libraries are usually supported by a specific department, such as surgery, and provide customized services to this sponsor. Departmental libraries continue to play an important role amid the debate over centralized, versus decentralized, library systems. On the basis of a limited survey, this paper describes a representative medical departmental library. PMID:8938327

Library Services to University Branch Campuses: The Ohio State Experience

ERIC Educational Resources Information Center

Schmidt, C. James; And Others

1970-01-01

The Ohio State University Main Library acquires and processes books, on a cost-supported contract basis, for each of four regional campus undergraduate libraries. The article describes requirements, rationale, and procedures, and diagrams procedural flow. (Author/NH)

User library service expectations in health science vs. other settings: a LibQUAL+ Study.

PubMed

Thompson, Bruce; Kyrillidou, Martha; Cook, Colleen

2007-12-01

To explore how the library service expectations and perceptions of users might differ across health-related libraries as against major research libraries not operating in a medical context; to determine whether users of medical libraries demand better library service quality, because the inability of users to access needed literature promptly may lead to a patient who cannot be properly diagnosed, or a diagnosis that cannot be properly treated. We compared LibQUAL+ total and subscale scores across three groups of US, Canadian and British libraries for this purpose. Anticipated differences in expectations for health as other library settings did not emerge. The expectations and perceptions are similar across different types of health science library settings, hospital and academic, and across other general research libraries.

Texas School Libraries: Standards, Resources, Services, and Students' Performance.

ERIC Educational Resources Information Center

Smith, Ester G.

This study of Texas school libraries had three objectives: examine school library resources, services, and use, on the basis of the School Library Programs: Standards and Guidelines for Texas and determine the need for updating these standards and guidelines so that they better serve communities across the state; determine the impact that school…

Campus-Library Collaboration with Makerspaces

ERIC Educational Resources Information Center

Lee, Rebekah J.

2017-01-01

Makerspaces provide an opportunity for libraries to build upon services they already offer while reaching out to students and faculty who do not frequent the library on a daily basis. By implementing a makerspace in the campus library, the space is seen as more neutral and approachable by students and staff from all academic departments. Broadly…

Montana State Plan for Federal Depository Library Service.

ERIC Educational Resources Information Center

Richards, Dennis L.; And Others

This report begins by explaining the purpose of and legal basis for the state depository library program as part of the national program operated by the U.S. Government Printing Office. Montana's selective federal depository libraries are then listed together with the regional depository library and several depository vacancies. Goals for both…

Smart Libraries: Integrating Communications Channels and Information Sources.

ERIC Educational Resources Information Center

Webb, T. D.; Jensen, E. A.

Noting that the changing nature of information delivery has established immediacy as the new basis for modern library service, this paper describes the new facilities design and floor plan for the library of Kapiolani Community College of the University of Hawaii. The new library was carefully designed so that students can move progressively from…

Online Education and Marketing: A Joint Approach.

ERIC Educational Resources Information Center

Day, J. M.; O'Donovan, K.

1988-01-01

Describes a cooperative study between a university library and department of library and information studies in which the library collected topics from clients as the basis for students' online search exercises. The discussion includes the benefits of client feedback to students and of publicity for its online service to the library. (Author/CLB)

Research on Energy-saving Shape Design of High School Library Building in Cold Region

NASA Astrophysics Data System (ADS)

Hui, Zhao; Weishuang, Xie; Zirui, Tong

2017-11-01

Considering climatic characteristics in cold region, existing high school libraries in Changchun are researched according to investigation of real conditions of these library buildings. Mathematical analysis and CAD methods are used to summarize the relation between building shape and building energy saving of high school library. Strategies are put forward for sustainable development of high school library building in cold region, providing reliable design basis for construction of high school libraries in Changchun.

Progress and Problems of Pennsylvania Libraries; a Re-Survey.

ERIC Educational Resources Information Center

Martin, Lowell A.

Following an earlier study of public libraries in Pennsylvania, issued in 1958, this "re-survey" has two purposes: (1) to determine the extent to which the 1958 Pennsylvania library program has been achieved and (2) to propose a revised or new Pennsylvania library program. The basis for the study is 1965-66 data which was obtained from…

The Public Library in a Changing Society Viewed in the Light of the UNESCO Manifest. The African Experience. Occasional Paper No. 13.

ERIC Educational Resources Information Center

Kaungamno, E. E.

Using the UNESCO Public Library Manifesto as a basis for discussion, this paper examines the role of the public library within developing countries and reviews the major developments in public library services in Africa subsequent to the two UNESCO seminars on Public Library Development held in Nigeria in 1962. A number of key statements from the…

Directory of Agencies Collecting Statistical Data from College & University Libraries.

ERIC Educational Resources Information Center

LaBrake, Lynn B., Ed.

This directory of organizations and agencies that survey academic libraries for statistical information on a regular basis includes 104 organizations representing state and federal agencies, college and university administrative bodies, accrediting organizations, all types of library organizations and associations, and publishers. The directory…

Efficient Computation of Sparse Matrix Functions for Large-Scale Electronic Structure Calculations: The CheSS Library.

PubMed

Mohr, Stephan; Dawson, William; Wagner, Michael; Caliste, Damien; Nakajima, Takahito; Genovese, Luigi

2017-10-10

We present CheSS, the "Chebyshev Sparse Solvers" library, which has been designed to solve typical problems arising in large-scale electronic structure calculations using localized basis sets. The library is based on a flexible and efficient expansion in terms of Chebyshev polynomials and presently features the calculation of the density matrix, the calculation of matrix powers for arbitrary powers, and the extraction of eigenvalues in a selected interval. CheSS is able to exploit the sparsity of the matrices and scales linearly with respect to the number of nonzero entries, making it well-suited for large-scale calculations. The approach is particularly adapted for setups leading to small spectral widths of the involved matrices and outperforms alternative methods in this regime. By coupling CheSS to the DFT code BigDFT, we show that such a favorable setup is indeed possible in practice. In addition, the approach based on Chebyshev polynomials can be massively parallelized, and CheSS exhibits excellent scaling up to thousands of cores even for relatively small matrix sizes.

StrBioLib: a Java library for development of custom computationalstructural biology applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chandonia, John-Marc

2007-05-14

Summary: StrBioLib is a library of Java classes useful fordeveloping software for computational structural biology research.StrBioLib contains classes to represent and manipulate proteinstructures, biopolymer sequences, sets of biopolymer sequences, andalignments between biopolymers based on either sequence or structure.Interfaces are provided to interact with commonly used bioinformaticsapplications, including (PSI)-BLAST, MODELLER, MUSCLE, and Primer3, andtools are provided to read and write many file formats used to representbioinformatic data. The library includes a general-purpose neural networkobject with multiple training algorithms, the Hooke and Jeeves nonlinearoptimization algorithm, and tools for efficient C-style string parsingand formatting. StrBioLib is the basis for the Pred2ary secondarystructure predictionmore » program, is used to build the ASTRAL compendium forsequence and structure analysis, and has been extensively tested throughuse in many smaller projects. Examples and documentation are available atthe site below.Availability: StrBioLib may be obtained under the terms ofthe GNU LGPL license from http://strbio.sourceforge.net/Contact:JMChandonia@lbl.gov« less

Reactivity effects in VVER-1000 of the third unit of the kalinin nuclear power plant at physical start-up. Computations in ShIPR intellectual code system with library of two-group cross sections generated by UNK code

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zizin, M. N.; Zimin, V. G.; Zizina, S. N., E-mail: zizin@adis.vver.kiae.ru

2010-12-15

The ShIPR intellectual code system for mathematical simulation of nuclear reactors includes a set of computing modules implementing the preparation of macro cross sections on the basis of the two-group library of neutron-physics cross sections obtained for the SKETCH-N nodal code. This library is created by using the UNK code for 3D diffusion computation of first VVER-1000 fuel loadings. Computation of neutron fields in the ShIPR system is performed using the DP3 code in the two-group diffusion approximation in 3D triangular geometry. The efficiency of all groups of control rods for the first fuel loading of the third unit ofmore » the Kalinin Nuclear Power Plant is computed. The temperature, barometric, and density effects of reactivity as well as the reactivity coefficient due to the concentration of boric acid in the reactor were computed additionally. Results of computations are compared with the experiment.« less

StrBioLib: a Java library for development of custom computational structural biology applications.

PubMed

Chandonia, John-Marc

2007-08-01

StrBioLib is a library of Java classes useful for developing software for computational structural biology research. StrBioLib contains classes to represent and manipulate protein structures, biopolymer sequences, sets of biopolymer sequences, and alignments between biopolymers based on either sequence or structure. Interfaces are provided to interact with commonly used bioinformatics applications, including (psi)-blast, modeller, muscle and Primer3, and tools are provided to read and write many file formats used to represent bioinformatic data. The library includes a general-purpose neural network object with multiple training algorithms, the Hooke and Jeeves non-linear optimization algorithm, and tools for efficient C-style string parsing and formatting. StrBioLib is the basis for the Pred2ary secondary structure prediction program, is used to build the astral compendium for sequence and structure analysis, and has been extensively tested through use in many smaller projects. Examples and documentation are available at the site below. StrBioLib may be obtained under the terms of the GNU LGPL license from http://strbio.sourceforge.net/

Reactivity effects in VVER-1000 of the third unit of the kalinin nuclear power plant at physical start-up. Computations in ShIPR intellectual code system with library of two-group cross sections generated by UNK code

NASA Astrophysics Data System (ADS)

Zizin, M. N.; Zimin, V. G.; Zizina, S. N.; Kryakvin, L. V.; Pitilimov, V. A.; Tereshonok, V. A.

2010-12-01

The ShIPR intellectual code system for mathematical simulation of nuclear reactors includes a set of computing modules implementing the preparation of macro cross sections on the basis of the two-group library of neutron-physics cross sections obtained for the SKETCH-N nodal code. This library is created by using the UNK code for 3D diffusion computation of first VVER-1000 fuel loadings. Computation of neutron fields in the ShIPR system is performed using the DP3 code in the two-group diffusion approximation in 3D triangular geometry. The efficiency of all groups of control rods for the first fuel loading of the third unit of the Kalinin Nuclear Power Plant is computed. The temperature, barometric, and density effects of reactivity as well as the reactivity coefficient due to the concentration of boric acid in the reactor were computed additionally. Results of computations are compared with the experiment.

The Science, Engineering and Technology Career Library Corner. Final report, February 1, 1995--January 31, 1996

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cole, P.R.

1996-03-01

A grant was made to install and pilot-test the Science, Engineering and Technology (SET) Career Library Corner at the New York Hall of Science. The SET Career Library Corner is located in a multi-media library setting where visitors can explore careers in a quiet, uninterrupted environment, in contrast to the original installation designed as a museum floor exhibit.

36 CFR 702.4 - Photographs.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 702.4 Parks, Forests, and Public Property LIBRARY OF CONGRESS CONDUCT ON LIBRARY PREMISES § 702.4 Photographs. (a) The policy set out herein applies to all individuals who are photographing Library of... interior of Library buildings and may set the conditions under which the photographing may take place. Such...

36 CFR 702.4 - Photographs.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 702.4 Parks, Forests, and Public Property LIBRARY OF CONGRESS CONDUCT ON LIBRARY PREMISES § 702.4 Photographs. (a) The policy set out herein applies to all individuals who are photographing Library of... interior of Library buildings and may set the conditions under which the photographing may take place. Such...

36 CFR 702.4 - Photographs.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 702.4 Parks, Forests, and Public Property LIBRARY OF CONGRESS CONDUCT ON LIBRARY PREMISES § 702.4 Photographs. (a) The policy set out herein applies to all individuals who are photographing Library of... interior of Library buildings and may set the conditions under which the photographing may take place. Such...

Understanding University Library Users' Mistreatment of Books

ERIC Educational Resources Information Center

Perez, Carmen; Cuadrado, Manuel; Cervera, Amparo

2009-01-01

This paper analyses university library users' attitudes towards book vandalism in order to develop a basis for intervention. Using a customer oriented approach data was collected from users who attended an academic library exhibition on vandalized books at a University campus. Respondents were asked both for their reactions to the vandalism as…

Does It Make a Sound: Are Open Access Monographs Discoverable in Library Catalogs?

ERIC Educational Resources Information Center

McCollough, Aaron

2017-01-01

This article describes an exploratory study examining the common perception among library-based publishers that open access academic publications (especially monographs) are not readily discoverable in library catalogs. Using titles from the Michigan Publishing imprint, digital culture books, the study provides an empirical basis for evaluating…

Shame: The Emotional Basis of Library Anxiety

ERIC Educational Resources Information Center

McAfee, Erin L.

2018-01-01

In 1986, Constance Mellon found that 75 to 85 percent of undergraduate students experienced library anxiety as well as shame about their anxiety. Fifteen years earlier, Helen Block Lewis began her groundbreaking research in shame theory. This paper explores the affective components of library anxiety using the pioneering research of Constance…

36 CFR § 702.4 - Photographs.

Code of Federal Regulations, 2013 CFR

2013-07-01

... § 702.4 Parks, Forests, and Public Property LIBRARY OF CONGRESS CONDUCT ON LIBRARY PREMISES § 702.4 Photographs. (a) The policy set out herein applies to all individuals who are photographing Library of... interior of Library buildings and may set the conditions under which the photographing may take place. Such...

Maine School Library Survey. Statistics of Public School Libraries in Maine Serving Grades K-12, from Data Gathered February 1990.

ERIC Educational Resources Information Center

Soule, Margaret

This survey of the current status of public school libraries in Maine was intended to provide statistical data as a basis for improving the school library media center program in these schools. Information was gathered that detailed how resources and delivery of services differed across grade level; across variation in size of school; between…

45 CFR 1706.130 - General prohibitions against discrimination.

Code of Federal Regulations, 2014 CFR

2014-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.130...

45 CFR 1706.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2012 CFR

2012-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.150...

45 CFR 1706.151 - Program accessibility: New construction and alterations.

Code of Federal Regulations, 2011 CFR

2011-10-01

...) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE...

45 CFR 1706.151 - Program accessibility: New construction and alterations.

Code of Federal Regulations, 2013 CFR

2013-10-01

...) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE...

45 CFR 1706.130 - General prohibitions against discrimination.

Code of Federal Regulations, 2013 CFR

2013-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.130...

45 CFR 1706.130 - General prohibitions against discrimination.

Code of Federal Regulations, 2011 CFR

2011-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.130...

45 CFR 1706.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2013 CFR

2013-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.150...

45 CFR 1706.151 - Program accessibility: New construction and alterations.

Code of Federal Regulations, 2012 CFR

2012-10-01

...) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE...

45 CFR 1706.151 - Program accessibility: New construction and alterations.

Code of Federal Regulations, 2014 CFR

2014-10-01

...) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE...

45 CFR 1706.149 - Program accessibility: Discrimination prohibited.

Code of Federal Regulations, 2014 CFR

2014-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.149...

45 CFR 1706.130 - General prohibitions against discrimination.

Code of Federal Regulations, 2012 CFR

2012-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.130...

45 CFR 1706.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2014 CFR

2014-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.150...

45 CFR 1706.149 - Program accessibility: Discrimination prohibited.

Code of Federal Regulations, 2011 CFR

2011-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.149...

45 CFR 1706.149 - Program accessibility: Discrimination prohibited.

Code of Federal Regulations, 2013 CFR

2013-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.149...

45 CFR 1706.149 - Program accessibility: Discrimination prohibited.

Code of Federal Regulations, 2012 CFR

2012-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.149...

45 CFR 1706.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.150...

45 CFR 1706.151 - Program accessibility: New construction and alterations.

Code of Federal Regulations, 2010 CFR

2010-10-01

...) NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE...

45 CFR 1706.149 - Program accessibility: Discrimination prohibited.

Code of Federal Regulations, 2010 CFR

2010-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.149...

45 CFR 1706.150 - Program accessibility: Existing facilities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.150...

45 CFR 1706.130 - General prohibitions against discrimination.

Code of Federal Regulations, 2010 CFR

2010-10-01

... COMMISSION ON LIBRARIES AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.130...

Minnesota Computer Aided Library System (MCALS); University of Minnesota Subsystem Cost/Benefits Analysis.

ERIC Educational Resources Information Center

Lourey, Eugene D., Comp.

The Minnesota Computer Aided Library System (MCALS) provides a basis of unification for library service program development in Minnesota for eventual linkage to the national information network. A prototype plan for communications functions is illustrated. A cost/benefits analysis was made to show the cost/effectiveness potential for MCALS. System…

Quality Management and Self Assessment Tools for Public Libraries.

ERIC Educational Resources Information Center

Evans, Margaret Kinnell

This paper describes a two-year study by the British Library Research and Innovation Centre that examined the potential of self-assessment for public library services. The approaches that formed the basis for the investigation were the Business Excellence Model, the Quality Framework, and the Democratic Approach. Core values were identified by…

36 CFR 701.3 - Methods of disposition of surplus and/or duplicate materials.

Code of Federal Regulations, 2010 CFR

2010-07-01

... organizations in the United States. It is the Library's policy, in keeping with the Federal Property and... surplus and/or duplicate materials. 701.3 Section 701.3 Parks, Forests, and Public Property LIBRARY OF...) Exchange. All libraries may make selections on an exchange basis from the materials available in the...

36 CFR 701.3 - Methods of disposition of surplus and/or duplicate materials.

Code of Federal Regulations, 2012 CFR

2012-07-01

... surplus and/or duplicate materials. 701.3 Section 701.3 Parks, Forests, and Public Property LIBRARY OF...) Exchange. All libraries may make selections on an exchange basis from the materials available in the... with dealers. Offers of exchange submitted by libraries shall be submitted to the Chief of the African...

36 CFR 701.3 - Methods of disposition of surplus and/or duplicate materials.

Code of Federal Regulations, 2011 CFR

2011-07-01

... surplus and/or duplicate materials. 701.3 Section 701.3 Parks, Forests, and Public Property LIBRARY OF...) Exchange. All libraries may make selections on an exchange basis from the materials available in the... with dealers. Offers of exchange submitted by libraries shall be submitted to the Chief of the African...

36 CFR 701.3 - Methods of disposition of surplus and/or duplicate materials.

Code of Federal Regulations, 2014 CFR

2014-07-01

... surplus and/or duplicate materials. 701.3 Section 701.3 Parks, Forests, and Public Property LIBRARY OF...) Exchange. All libraries may make selections on an exchange basis from the materials available in the... with dealers. Offers of exchange submitted by libraries shall be submitted to the Chief of the African...

Future Challenges in Library Science.

ERIC Educational Resources Information Center

Murgai, Sarla R.

This paper considers a number of potential developments for the future of library science and the roles of information professionals. Among the projections are: (1) the use of computers and management science operations research methodologies will form the basis of decision making in libraries in the future; (2) a concerted effort will be made to…

The Use of On-Line Technology in Connecticut Libraries, 1980-1985.

ERIC Educational Resources Information Center

Epstein, Hank; Epstein, Susan Baerg

This report describing the current and future use of online automation technology in Connecticut libraries provides recommendations designed to assist Connecticut libraries in making more effective use of current systems, in selecting the most appropriate new systems, and by providing a basis for effective statewide planning that will take…

Libraries as 'everyday' settings: the Glasgow MCISS project.

PubMed

Whitelaw, Sandy; Coburn, Jonathan; Lacey, Marion; McKee, Martin J; Hill, Carol

2017-10-01

A settings-based approach is now well-established in health promotion, initially undertaken in conventional places like schools and workplaces, but more recently being expressed in a wider range of what Torp et al. call 'everyday' settings. In this context, libraries have emerged as another potential setting whose ubiquity and accessibility suggests that they may be particularly effective in addressing health inequalities. Drawing on a case study-the Glasgow Macmillan Cancer Information and Support Services Library project-this paper reports on the potential for seeing 'libraries as settings' and in the context of a set of associated theoretical resources, specifically scrutinizes the nature of initiative implementation. Data were drawn from multiple sources: semi-structured interviews and focus groups with strategic partners and stakeholders, operational staff, project volunteers, service users and members of the general public. Qualitative data were complemented by quantitative insights from surveys with members of the partnership, libraries staff and volunteers. Despite some concerns associated with potentially hostile cultural and financial contexts that might threaten longer term sustainability, insights suggested that in pragmatic terms, the project was attracting sizable 'footfall' and successfully addressing a range of needs. Additionally, the formal implementation processes associated with project implementation were considered to have been highly successful in embedding the model into the library culture. In summary, there is evidence that libraries have the potential to be considered as supportive settings and could act as a model for an emergent vision of what libraries do. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL).

PubMed

Koestler, Devin C; Jones, Meaghan J; Usset, Joseph; Christensen, Brock C; Butler, Rondi A; Kobor, Michael S; Wiencke, John K; Kelsey, Karl T

2016-03-08

Confounding due to cellular heterogeneity represents one of the foremost challenges currently facing Epigenome-Wide Association Studies (EWAS). Statistical methods leveraging the tissue-specificity of DNA methylation for deconvoluting the cellular mixture of heterogenous biospecimens offer a promising solution, however the performance of such methods depends entirely on the library of methylation markers being used for deconvolution. Here, we introduce a novel algorithm for Identifying Optimal Libraries (IDOL) that dynamically scans a candidate set of cell-specific methylation markers to find libraries that optimize the accuracy of cell fraction estimates obtained from cell mixture deconvolution. Application of IDOL to training set consisting of samples with both whole-blood DNA methylation data (Illumina HumanMethylation450 BeadArray (HM450)) and flow cytometry measurements of cell composition revealed an optimized library comprised of 300 CpG sites. When compared existing libraries, the library identified by IDOL demonstrated significantly better overall discrimination of the entire immune cell landscape (p = 0.038), and resulted in improved discrimination of 14 out of the 15 pairs of leukocyte subtypes. Estimates of cell composition across the samples in the training set using the IDOL library were highly correlated with their respective flow cytometry measurements, with all cell-specific R (2)>0.99 and root mean square errors (RMSEs) ranging from [0.97 % to 1.33 %] across leukocyte subtypes. Independent validation of the optimized IDOL library using two additional HM450 data sets showed similarly strong prediction performance, with all cell-specific R (2)>0.90 and R M S E<4.00 %. In simulation studies, adjustments for cell composition using the IDOL library resulted in uniformly lower false positive rates compared to competing libraries, while also demonstrating an improved capacity to explain epigenome-wide variation in DNA methylation within two large publicly available HM450 data sets. Despite consisting of half as many CpGs compared to existing libraries for whole blood mixture deconvolution, the optimized IDOL library identified herein resulted in outstanding prediction performance across all considered data sets and demonstrated potential to improve the operating characteristics of EWAS involving adjustments for cell distribution. In addition to providing the EWAS community with an optimized library for whole blood mixture deconvolution, our work establishes a systematic and generalizable framework for the assembly of libraries that improve the accuracy of cell mixture deconvolution.

36 CFR § 701.3 - Methods of disposition of surplus and/or duplicate materials.

Code of Federal Regulations, 2013 CFR

2013-07-01

... surplus and/or duplicate materials. § 701.3 Section § 701.3 Parks, Forests, and Public Property LIBRARY... materials. (a) Exchange. All libraries may make selections on an exchange basis from the materials available... be exchanged with dealers. Offers of exchange submitted by libraries shall be submitted to the Chief...

A Study of the Effects of Creative Dramatics on the Progress in Use of the Library, Reading Interests, Reading Achievement, Self-Concept, Creativity, and Empathy of Fourth and Fifth Grade Children.

ERIC Educational Resources Information Center

Ziegler, Elsie Mae

To appraise the value of a creative dramatics program in a public library setting was the purpose of this study. Nine public library branches comprised the setting for the experiment. At each branch there were three units: (1) creative dramatics, (2) storytelling, and (3) library usage. Storytelling and library usage were the control group. Pre…

STAR Library Education Network: a hands-on learning program for libraries and their communities

NASA Astrophysics Data System (ADS)

Dusenbery, P.

2010-12-01

Science and technology are widely recognized as major drivers of innovation and industry (e.g. Rising above the Gathering Storm, 2006). While the focus for education reform is on school improvement, there is considerable research that supports the role that out-of-school experiences can play in student achievement and public understanding of STEM disciplines. Libraries provide an untapped resource for engaging underserved youth and their families in fostering an appreciation and deeper understanding of science and technology topics. Designed spaces, like libraries, allow lifelong, life-wide, and life-deep learning to take place though the research basis for learning in libraries is not as developed as other informal settings like science centers. The Space Science Institute’s National Center for Interactive Learning (NCIL) in partnership with the American Library Association (ALA), the Lunar and Planetary Institute (LPI), and the National Girls Collaborative Project (NGCP) have received funding from NSF to develop a national education project called the STAR Library Education Network: a hands-on learning program for libraries and their communities (or STAR-Net for short). STAR stands for Science-Technology, Activities and Resources. The overarching goal of the project is to reach underserved youth and their families with informal STEM learning experiences. This project will deepen our knowledge of informal/lifelong learning that takes place in libraries and establish a learning model that can be compared to the more established free-choice learning model for science centers and museums. The project includes the development of two STEM hands-on exhibits on topics that are of interest to library staff and their patrons: Discover Earth and Discover Tech. In addition, the project will produce resources and inquiry-based activities that libraries can use to enrich the exhibit experience. Additional resources will be provided through partnerships with relevant professional science and technology organizations (e.g. American Geophysical Union; National Academy of Engineering) that will provide speakers for host library events and webinars. Online and in-person workshops will be conducted for library staff with a focus on increasing content knowledge and improving facilitation expertise. This presentation will report on strategic planning activities for STAR-Net, a Community of Practice model, and the evaluation/research components of this national education program.

Quality evaluation of tandem mass spectral libraries.

PubMed

Oberacher, Herbert; Weinmann, Wolfgang; Dresen, Sebastian

2011-06-01

Tandem mass spectral libraries are gaining more and more importance for the identification of unknowns in different fields of research, including metabolomics, forensics, toxicology, and environmental analysis. Particularly, the recent invention of reliable, robust, and transferable libraries has increased the general acceptance of these tools. Herein, we report on results obtained from thorough evaluation of the match reliabilities of two tandem mass spectral libraries: the MSforID library established by the Oberacher group in Innsbruck and the Weinmann library established by the Weinmann group in Freiburg. Three different experiments were performed: (1) Spectra of the libraries were searched against their corresponding library after excluding either this single compound-specific spectrum or all compound-specific spectra prior to searching; (2) the libraries were searched against each other using either library as reference set or sample set; (3) spectra acquired on different mass spectrometric instruments were matched to both libraries. Almost 13,000 tandem mass spectra were included in this study. The MSforID search algorithm was used for spectral matching. Statistical evaluation of the library search results revealed that principally both libraries enable the sensitive and specific identification of compounds. Due to higher mass accuracy of the QqTOF compared with the QTrap instrument, matches to the MSforID library were more reliable when comparing spectra with both libraries. Furthermore, only the MSforID library was shown to be efficiently transferable to different kinds of tandem mass spectrometers, including "tandem-in-time" instruments; this is due to the coverage of a large range of different collision energy settings-including the very low range-which is an outstanding characteristics of the MSforID library.

Library fingerprints: a novel approach to the screening of virtual libraries.

PubMed

Klon, Anthony E; Diller, David J

2007-01-01

We propose a novel method to prioritize libraries for combinatorial synthesis and high-throughput screening that assesses the viability of a particular library on the basis of the aggregate physical-chemical properties of the compounds using a naïve Bayesian classifier. This approach prioritizes collections of related compounds according to the aggregate values of their physical-chemical parameters in contrast to single-compound screening. The method is also shown to be useful in screening existing noncombinatorial libraries when the compounds in these libraries have been previously clustered according to their molecular graphs. We show that the method used here is comparable or superior to the single-compound virtual screening of combinatorial libraries and noncombinatorial libraries and is superior to the pairwise Tanimoto similarity searching of a collection of combinatorial libraries.

User Requirements in Identifying Desired Works in a Large Library. Final Report.

ERIC Educational Resources Information Center

Lipetz, Ben-Ami

Utilization of the card catalog in the main library (Sterling Memorial Library) of Yale University was studied over a period of more than a year. Traffic flow in the catalog was observed, and was used as the basis for scheduling interviews with a representative sample of catalog users at the moment of catalog use. More than 2000 interviews were…

The Development of the National Library System on the Basis of the German Democratic Republic's Social Development.

ERIC Educational Resources Information Center

Schumann, Wolfgang; Schwarz, Gerhard

This historical review considers the rise of the German Democratic Republic's (GDR) system of libraries since its inception in 1945. Sections detail the following: (1) background; (2) tasks of the state organs in the development of the library network, with attention to legislation, planning, and management of the system; (3) role of the GDR…

Models and Management of Student Employees in an Australian University Library

ERIC Educational Resources Information Center

O'Neil, Frances; Comley, Jenny

2010-01-01

Since 2008, Victoria University (VU) Library has employed 20 or more Student Assistants annually who work on a casual basis for up to 12 hours per week during terms/semesters to staff the Library in Study Hall mode (where there is self-service access to PCs and collections and limited staff assistance). This initiative appears to have been highly…

Optimization of an RNA-Seq Differential Gene Expression Analysis Depending on Biological Replicate Number and Library Size

PubMed Central

Lamarre, Sophie; Frasse, Pierre; Zouine, Mohamed; Labourdette, Delphine; Sainderichin, Elise; Hu, Guojian; Le Berre-Anton, Véronique; Bouzayen, Mondher; Maza, Elie

2018-01-01

RNA-Seq is a widely used technology that allows an efficient genome-wide quantification of gene expressions for, for example, differential expression (DE) analysis. After a brief review of the main issues, methods and tools related to the DE analysis of RNA-Seq data, this article focuses on the impact of both the replicate number and library size in such analyses. While the main drawback of previous relevant studies is the lack of generality, we conducted both an analysis of a two-condition experiment (with eight biological replicates per condition) to compare the results with previous benchmark studies, and a meta-analysis of 17 experiments with up to 18 biological conditions, eight biological replicates and 100 million (M) reads per sample. As a global trend, we concluded that the replicate number has a larger impact than the library size on the power of the DE analysis, except for low-expressed genes, for which both parameters seem to have the same impact. Our study also provides new insights for practitioners aiming to enhance their experimental designs. For instance, by analyzing both the sensitivity and specificity of the DE analysis, we showed that the optimal threshold to control the false discovery rate (FDR) is approximately 2−r, where r is the replicate number. Furthermore, we showed that the false positive rate (FPR) is rather well controlled by all three studied R packages: DESeq, DESeq2, and edgeR. We also analyzed the impact of both the replicate number and library size on gene ontology (GO) enrichment analysis. Interestingly, we concluded that increases in the replicate number and library size tend to enhance the sensitivity and specificity, respectively, of the GO analysis. Finally, we recommend to RNA-Seq practitioners the production of a pilot data set to strictly analyze the power of their experimental design, or the use of a public data set, which should be similar to the data set they will obtain. For individuals working on tomato research, on the basis of the meta-analysis, we recommend at least four biological replicates per condition and 20 M reads per sample to be almost sure of obtaining about 1000 DE genes if they exist. PMID:29491871

The structure of a thermophilic kinase shapes fitness upon random circular permutation

PubMed Central

Jones, Alicia M.; Mehta, Manan M.; Thomas, Emily E.; Atkinson, Joshua T.; Segall-Shapiro, Thomas H.; Liu, Shirley; Silberg, Jonathan J.

2016-01-01

Proteins can be engineered for synthetic biology through circular permutation, a sequence rearrangement where native protein termini become linked and new termini are created elsewhere through backbone fission. However, it remains challenging to anticipate a protein’s functional tolerance to circular permutation. Here, we describe new transposons for creating libraries of randomly circularly permuted proteins that minimize peptide additions at their termini, and we use transposase mutagenesis to study the tolerance of a thermophilic adenylate kinase (AK) to circular permutation. We find that libraries expressing permuted AK with either short or long peptides amended to their N-terminus yield distinct sets of active variants and present evidence that this trend arises because permuted protein expression varies across libraries. Mapping all sites that tolerate backbone cleavage onto AK structure reveals that the largest contiguous regions of sequence that lack cleavage sites are proximal to the phosphotransfer site. A comparison of our results with a range of structure-derived parameters further showed that retention of function correlates to the strongest extent with the distance to the phosphotransfer site, amino acid variability in an AK family sequence alignment, and residue-level deviations in superimposed AK structures. Our work illustrates how permuted protein libraries can be created with minimal peptide additions using transposase mutagenesis, and they reveal a challenge of maintaining consistent expression across permuted variants in a library that minimizes peptide additions. Furthermore, these findings provide a basis for interpreting responses of thermophilic phosphotransferases to circular permutation by calibrating how different structure-derived parameters relate to retention of function in a cellular selection. PMID:26976658

The Structure of a Thermophilic Kinase Shapes Fitness upon Random Circular Permutation.

PubMed

Jones, Alicia M; Mehta, Manan M; Thomas, Emily E; Atkinson, Joshua T; Segall-Shapiro, Thomas H; Liu, Shirley; Silberg, Jonathan J

2016-05-20

Proteins can be engineered for synthetic biology through circular permutation, a sequence rearrangement in which native protein termini become linked and new termini are created elsewhere through backbone fission. However, it remains challenging to anticipate a protein's functional tolerance to circular permutation. Here, we describe new transposons for creating libraries of randomly circularly permuted proteins that minimize peptide additions at their termini, and we use transposase mutagenesis to study the tolerance of a thermophilic adenylate kinase (AK) to circular permutation. We find that libraries expressing permuted AKs with either short or long peptides amended to their N-terminus yield distinct sets of active variants and present evidence that this trend arises because permuted protein expression varies across libraries. Mapping all sites that tolerate backbone cleavage onto AK structure reveals that the largest contiguous regions of sequence that lack cleavage sites are proximal to the phosphotransfer site. A comparison of our results with a range of structure-derived parameters further showed that retention of function correlates to the strongest extent with the distance to the phosphotransfer site, amino acid variability in an AK family sequence alignment, and residue-level deviations in superimposed AK structures. Our work illustrates how permuted protein libraries can be created with minimal peptide additions using transposase mutagenesis, and it reveals a challenge of maintaining consistent expression across permuted variants in a library that minimizes peptide additions. Furthermore, these findings provide a basis for interpreting responses of thermophilic phosphotransferases to circular permutation by calibrating how different structure-derived parameters relate to retention of function in a cellular selection.

Biofragments: An Approach towards Predicting Protein Function Using Biologically Related Fragments and its Application to Mycobacterium tuberculosis CYP126

PubMed Central

Hudson, Sean A; Mashalidis, Ellene H; Bender, Andreas; McLean, Kirsty J; Munro, Andrew W; Abell, Chris

2014-01-01

We present a novel fragment-based approach that tackles some of the challenges for chemical biology of predicting protein function. The general approach, which we have termed biofragments, comprises two key stages. First, a biologically relevant fragment library (biofragment library) can be designed and constructed from known sets of substrate-like ligands for a protein class of interest. Second, the library can be screened for binding to a novel putative ligand-binding protein from the same or similar class, and the characterization of hits provides insight into the basis of ligand recognition, selectivity, and function at the substrate level. As a proof-of-concept, we applied the biofragments approach to the functionally uncharacterized Mycobacterium tuberculosis (Mtb) cytochrome P450 isoform, CYP126. This led to the development of a tailored CYP biofragment library with notable 3D characteristics and a significantly higher screening hit rate (14 %) than standard drug-like fragment libraries screened previously against Mtb CYP121 and 125 (4 % and 1 %, respectively). Biofragment hits were identified that make both substrate-like type-I and inhibitor-like type-II interactions with CYP126. A chemical-fingerprint-based substrate model was built from the hits and used to search a virtual TB metabolome, which led to the discovery that CYP126 has a strong preference for the recognition of aromatics and substrate-like type-I binding of chlorophenol moieties within the active site near the heme. Future catalytic analyses will be focused on assessing CYP126 for potential substrate oxidative dehalogenation. PMID:24677424

45 CFR 1614.3 - Range of activities.

Code of Federal Regulations, 2013 CFR

2013-10-01

... assistance, research, advice and counsel, or the use of recipient facilities, libraries, computer assisted... bono basis through the provision of community legal education, training, technical assistance, research, advice and counsel; co-counseling arrangements; or the use of private law firm facilities, libraries...

45 CFR 1614.3 - Range of activities.

Code of Federal Regulations, 2014 CFR

2014-10-01

... assistance, research, advice and counsel, or the use of recipient facilities, libraries, computer assisted... bono basis through the provision of community legal education, training, technical assistance, research, advice and counsel; co-counseling arrangements; or the use of private law firm facilities, libraries...

45 CFR 1614.3 - Range of activities.

Code of Federal Regulations, 2012 CFR

2012-10-01

... assistance, research, advice and counsel, or the use of recipient facilities, libraries, computer assisted... bono basis through the provision of community legal education, training, technical assistance, research, advice and counsel; co-counseling arrangements; or the use of private law firm facilities, libraries...

SSMNG Software Service Manager: A Scalable Building Blocks Architecture for PUS Services & FDIR Management

NASA Astrophysics Data System (ADS)

Lisio, Giovanni; Candia, Sante; Campolo, Giovanni; Pascucci, Dario

2011-08-01

Thales Alenia Space Italy has carried out the definition of a configurable (on mission basis) PUS ECSS-E_70- 41A see [3] Centralised Services Layer, characterised by:- a mission-independent set of 'classes' implementing the services logic.- a mission-dependent set of configuration data and selection flags.The software components belonging to this layer implement the PUS standard services ECSS-E_70-41A and a set of mission-specific services. The design of this layer has been performed by separating the services mechanisms (mission-independent execution logic) from the services configuration information (mission-dependent data). Once instantiated for a specific mission, the PUS Centralised Services Layer offers a large set of capabilities available to the CSCI's Applications Layer. This paper describes the building blocks PUS architectural solution developed by Thales Alenia Space Italy, emphasizing the mechanisms which allow easy configuration of the Scalable PUS library to fulfill the requirements of different missions. This paper also focus the Thales Alenia Space solution to automatically generate the mission-specific "PUS Services" flight software based on mission specific requirements. Building the PUS services mechanisms, which are configurable on mission basis is part of the PRIMA (Multipurpose Spacecraft Bus ) 'missionisation' process improvement. PRIMA Platform Avionics Software (ASW) is continuously evolving to improve modularity and standardization of interfaces and of SW components (see references in [1]).

Just a Book in a Library? The Sybil Campbell Library Collection Fostering International Friendship amongst Graduate Women

ERIC Educational Resources Information Center

Spencer, Stephanie

2013-01-01

In 1927 the British Federation of University Women (BFUW) established Crosby Hall in London as a hall of residence for women graduates from overseas. The Federation aimed to foster international understanding and peace at a time of social and political turmoil. Accessions to the library at the Hall were on a somewhat ad hoc basis and provide an…

Reduced Order Model Basis Vector Generation: Generates Basis Vectors fro ROMs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arrighi, Bill

2016-03-03

libROM is a library that implements order reduction via singular value decomposition (SVD) of sampled state vectors. It implements 2 parallel, incremental SVD algorithms and one serial, non-incremental algorithm. It also provides a mechanism for adaptive sampling of basis vectors.

Chemical Space of DNA-Encoded Libraries.

PubMed

Franzini, Raphael M; Randolph, Cassie

2016-07-28

In recent years, DNA-encoded chemical libraries (DECLs) have attracted considerable attention as a potential discovery tool in drug development. Screening encoded libraries may offer advantages over conventional hit discovery approaches and has the potential to complement such methods in pharmaceutical research. As a result of the increased application of encoded libraries in drug discovery, a growing number of hit compounds are emerging in scientific literature. In this review we evaluate reported encoded library-derived structures and identify general trends of these compounds in relation to library design parameters. We in particular emphasize the combinatorial nature of these libraries. Generally, the reported molecules demonstrate the ability of this technology to afford hits suitable for further lead development, and on the basis of them, we derive guidelines for DECL design.

Understanding the foundation: the state of generalist search education in library schools as related to the needs of expert searchers in medical libraries

PubMed Central

Nicholson, Scott

2005-01-01

Purpose: The paper explores the current state of generalist search education in library schools and considers that foundation in respect to the Medical Library Association's statement on expert searching. Setting/Subjects: Syllabi from courses with significant searching components were examined from ten of the top library schools, as determined by the U.S. News & World Report rankings. Methodology: Mixed methods were used, but primarily quantitative bibliometric methods were used. Results: The educational focus in these searching components was on understanding the generalist searching resources and typical users and on performing a reflective search through application of search strategies, controlled vocabulary, and logic appropriate to the search tool. There is a growing emphasis on Web-based search tools and a movement away from traditional set-based searching and toward free-text search strategies. While a core set of authors is used in these courses, no core set of readings is used. Discussion/Conclusion: While library schools provide a strong foundation, future medical librarians still need to take courses that introduce them to the resources, settings, and users associated with medical libraries. In addition, as more emphasis is placed on Web-based search tools and free-text searching, instructors of the specialist medical informatics courses will need to focus on teaching traditional search methods appropriate for common tools in the medical domain. PMID:15685276

Using relational databases for improved sequence similarity searching and large-scale genomic analyses.

PubMed

Mackey, Aaron J; Pearson, William R

2004-10-01

Relational databases are designed to integrate diverse types of information and manage large sets of search results, greatly simplifying genome-scale analyses. Relational databases are essential for management and analysis of large-scale sequence analyses, and can also be used to improve the statistical significance of similarity searches by focusing on subsets of sequence libraries most likely to contain homologs. This unit describes using relational databases to improve the efficiency of sequence similarity searching and to demonstrate various large-scale genomic analyses of homology-related data. This unit describes the installation and use of a simple protein sequence database, seqdb_demo, which is used as a basis for the other protocols. These include basic use of the database to generate a novel sequence library subset, how to extend and use seqdb_demo for the storage of sequence similarity search results and making use of various kinds of stored search results to address aspects of comparative genomic analysis.

GIS Application System Design Applied to Information Monitoring

NASA Astrophysics Data System (ADS)

Qun, Zhou; Yujin, Yuan; Yuena, Kang

Natural environment information management system involves on-line instrument monitoring, data communications, database establishment, information management software development and so on. Its core lies in collecting effective and reliable environmental information, increasing utilization rate and sharing degree of environment information by advanced information technology, and maximizingly providing timely and scientific foundation for environmental monitoring and management. This thesis adopts C# plug-in application development and uses a set of complete embedded GIS component libraries and tools libraries provided by GIS Engine to finish the core of plug-in GIS application framework, namely, the design and implementation of framework host program and each functional plug-in, as well as the design and implementation of plug-in GIS application framework platform. This thesis adopts the advantages of development technique of dynamic plug-in loading configuration, quickly establishes GIS application by visualized component collaborative modeling and realizes GIS application integration. The developed platform is applicable to any application integration related to GIS application (ESRI platform) and can be as basis development platform of GIS application development.

A Survey of Popular R Packages for Cluster Analysis

ERIC Educational Resources Information Center

Flynt, Abby; Dean, Nema

2016-01-01

Cluster analysis is a set of statistical methods for discovering new group/class structure when exploring data sets. This article reviews the following popular libraries/commands in the R software language for applying different types of cluster analysis: from the stats library, the kmeans, and hclust functions; the mclust library; the poLCA…

Academic Library Use of Facebook: Building Relationships with Students

ERIC Educational Resources Information Center

Phillips, Nancy Kim

2011-01-01

A content analysis was conducted of status messages posted by academic libraries on seventeen Facebook pages. In addition to being informational, libraries attempt to engage and establish rapport with students through Facebook. The university setting not only creates a context for messages, but also offers a mutual set of experiences and values…

International Federation of Library Associations Annual Conference Papers. General Research Libraries Division: Parliamentary Libraries and National Libraries Sections (47th, Leipzig, East Germany, August 17-22, 1981).

ERIC Educational Resources Information Center

Gude, Gilbert; And Others

This set of papers presented to the General Research Libraries Division of the International Federation of Library Associations (IFLA) during its 47th annual conference (1981) includes: "The Effect of the Introduction of Computers on Library and Research Staff," by Gilbert Gude; "Libraries as Information Service Agencies…

Libraries for Lifelong Literacy: Unrestricted Access to Information as a Basis for Lifelong Learning and Empowerment. IFLA/FAIFE Theme Report. World Report Series Volume IV

ERIC Educational Resources Information Center

Seidelin, Susanne, Ed.; Hamilton, Stuart, Ed.; Sturges, Paul, Ed.

2004-01-01

The IFLA/FAIFE (International Federation of Library Associations and Institutions/Committee on Free Access to Information and Freedom of Expression) Theme Report 2004 presents visions of how libraries can promote literacy and lifelong learning. The literacy process has to be recognised as inclusive of all ranges of communication, and it occurs at…

Library Management: Quantifying Goals. Papers Presented at the Fourth Annual Library Science Institute (Indiana State University, Terre Haute, Indiana, April 27-29, 1972). Changing Concept Series No. 2.

ERIC Educational Resources Information Center

Kim, Choong H., Ed.; And Others

Recognizing that the rational determination of priority goals for library services is only possible on the basis of objectively defined quantities, these papers discuss the problems of such quantification. The lead paper reviews current thought on the subject, noting the lack of practical techniques for the disciplined measurement of library…

45 CFR 1706.170 - Compliance procedures.

Code of Federal Regulations, 2013 CFR

2013-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.170 Compliance procedures. (a... Commission on Libraries and Information Science, Suite 3122, GSA-ROB 3, Washington, DC 20024. (d) The agency...

45 CFR 1706.170 - Compliance procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.170 Compliance procedures. (a... Commission on Libraries and Information Science, Suite 3122, GSA-ROB 3, Washington, DC 20024. (d) The agency...

45 CFR 1706.170 - Compliance procedures.

Code of Federal Regulations, 2012 CFR

2012-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.170 Compliance procedures. (a... Commission on Libraries and Information Science, Suite 3122, GSA-ROB 3, Washington, DC 20024. (d) The agency...

45 CFR 1706.170 - Compliance procedures.

Code of Federal Regulations, 2014 CFR

2014-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.170 Compliance procedures. (a... Commission on Libraries and Information Science, Suite 3122, GSA-ROB 3, Washington, DC 20024. (d) The agency...

45 CFR 1706.170 - Compliance procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.170 Compliance procedures. (a... Commission on Libraries and Information Science, Suite 3122, GSA-ROB 3, Washington, DC 20024. (d) The agency...

Libraries as Content Producers: How Library Publishing Services Address the Reading Experience

ERIC Educational Resources Information Center

Tracy, Daniel G.

2017-01-01

This study establishes baseline information about the ways library publishing services integrate user studies of their readers, as well as common barriers to doing so. The Library Publishing Coalition defines library publishing as "the set of activities led by college and university libraries to support the creation, dissemination, and…

SkData: data sets and algorithm evaluation protocols in Python

NASA Astrophysics Data System (ADS)

Bergstra, James; Pinto, Nicolas; Cox, David D.

2015-01-01

Machine learning benchmark data sets come in all shapes and sizes, whereas classification algorithms assume sanitized input, such as (x, y) pairs with vector-valued input x and integer class label y. Researchers and practitioners know all too well how tedious it can be to get from the URL of a new data set to a NumPy ndarray suitable for e.g. pandas or sklearn. The SkData library handles that work for a growing number of benchmark data sets (small and large) so that one-off in-house scripts for downloading and parsing data sets can be replaced with library code that is reliable, community-tested, and documented. The SkData library also introduces an open-ended formalization of training and testing protocols that facilitates direct comparison with published research. This paper describes the usage and architecture of the SkData library.

Evaluation of the Pool Critical Assembly Benchmark with Explicitly-Modeled Geometry using MCNP6

DOE PAGES

Kulesza, Joel A.; Martz, Roger Lee

2017-03-01

Despite being one of the most widely used benchmarks for qualifying light water reactor (LWR) radiation transport methods and data, no benchmark calculation of the Oak Ridge National Laboratory (ORNL) Pool Critical Assembly (PCA) pressure vessel wall benchmark facility (PVWBF) using MCNP6 with explicitly modeled core geometry exists. As such, this paper provides results for such an analysis. First, a criticality calculation is used to construct the fixed source term. Next, ADVANTG-generated variance reduction parameters are used within the final MCNP6 fixed source calculations. These calculations provide unadjusted dosimetry results using three sets of dosimetry reaction cross sections of varyingmore » ages (those packaged with MCNP6, from the IRDF-2002 multi-group library, and from the ACE-formatted IRDFF v1.05 library). These results are then compared to two different sets of measured reaction rates. The comparison agrees in an overall sense within 2% and on a specific reaction- and dosimetry location-basis within 5%. Except for the neptunium dosimetry, the individual foil raw calculation-to-experiment comparisons usually agree within 10% but is typically greater than unity. Finally, in the course of developing these calculations, geometry that has previously not been completely specified is provided herein for the convenience of future analysts.« less

The Roles That Librarians and Libraries Play in Distance Education Settings

ERIC Educational Resources Information Center

Corbett, Amanda; Brown, Abbie

2015-01-01

This article explores the literature that focuses on the various roles librarians and libraries play in distance education settings. Learners visit libraries either in person or via networked computing technology to ask for help with their online courses. Questions range from how to upload a document with a learning management system, to how to…

Automation of internal library operations in academic health sciences libraries: a state of the art report.

PubMed Central

Grefsheim, S F; Larson, R H; Bader, S A; Matheson, N W

1982-01-01

A survey of automated records management in the United States and Canada was developed to identify existing on-line library systems and technical expertise. Follow-up interviews were conducted with ten libraries. Tables compare the features and availability of four main frame and four minicomputer systems. Results showed: a trend toward vendor-supplied systems; little coordination of efforts among schools; current system developments generally on a universitywide basis; and the importance of having the cooperation of campus computer facilities to the success of automation efforts. PMID:7066571

Client value models provide a framework for rational library planning (or, phrasing the answer in the form of a question).

PubMed

Van Moorsel, Guillaume

2005-01-01

Libraries often do not know how clients value their product/ service offerings. Yet at a time when the mounting costs for library support are increasingly difficult to justify to the parent institution, the library's ability to gauge the value of its offerings to clients has never been more critical. Client Value Models (CVMs) establish a common definition of value elements-or a "value vocabulary"-for libraries and their clients, thereby providing a basis upon which to make rational planning decisions regarding product/service acquisition and development. The CVM concept is borrowed from business and industry, but its application has a natural fit in libraries. This article offers a theoretical consideration and practical illustration of CVM application in libraries.

Development of an Ada package library

NASA Technical Reports Server (NTRS)

Burton, Bruce; Broido, Michael

1986-01-01

A usable prototype Ada package library was developed and is currently being evaluated for use in large software development efforts. The library system is comprised of an Ada-oriented design language used to facilitate the collection of reuse information, a relational data base to store reuse information, a set of reusable Ada components and tools, and a set of guidelines governing the system's use. The prototyping exercise is discussed and the lessons learned from it have led to the definition of a comprehensive tool set to facilitate software reuse.

An expressed sequence tag (EST) library for Drosophila serrata, a model system for sexual selection and climatic adaptation studies.

PubMed

Frentiu, Francesca D; Adamski, Marcin; McGraw, Elizabeth A; Blows, Mark W; Chenoweth, Stephen F

2009-01-21

The native Australian fly Drosophila serrata belongs to the highly speciose montium subgroup of the melanogaster species group. It has recently emerged as an excellent model system with which to address a number of important questions, including the evolution of traits under sexual selection and traits involved in climatic adaptation along latitudinal gradients. Understanding the molecular genetic basis of such traits has been limited by a lack of genomic resources for this species. Here, we present the first expressed sequence tag (EST) collection for D. serrata that will enable the identification of genes underlying sexually-selected phenotypes and physiological responses to environmental change and may help resolve controversial phylogenetic relationships within the montium subgroup. A normalized cDNA library was constructed from whole fly bodies at several developmental stages, including larvae and adults. Assembly of 11,616 clones sequenced from the 3' end allowed us to identify 6,607 unique contigs, of which at least 90% encoded peptides. Partial transcripts were discovered from a variety of genes of evolutionary interest by BLASTing contigs against the 12 Drosophila genomes currently sequenced. By incorporating into the cDNA library multiple individuals from populations spanning a large portion of the geographical range of D. serrata, we were able to identify 11,057 putative single nucleotide polymorphisms (SNPs), with 278 different contigs having at least one "double hit" SNP that is highly likely to be a real polymorphism. At least 394 EST-associated microsatellite markers, representing 355 different contigs, were also found, providing an additional set of genetic markers. The assembled EST library is available online at http://www.chenowethlab.org/serrata/index.cgi. We have provided the first gene collection and largest set of polymorphic genetic markers, to date, for the fly D. serrata. The EST collection will provide much needed genomic resources for this model species and facilitate comparative evolutionary studies within the montium subgroup of the D. melanogaster lineage.

45 CFR 1181.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... HUMANITIES INSTITUTE OF MUSEUM AND LIBRARY SERVICES ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY THE INSTITUTE OF MUSEUM AND LIBRARY SERVICES § 1181.110 Self-evaluation. (a) The agency shall, by April 9, 1987, evaluate its current policies and practices, and the...

Special Problems in the Library Setting.

ERIC Educational Resources Information Center

Keller, Daniel P.

1997-01-01

Discussion of violence in the workplace focuses on libraries. Highlights include types of violence in libraries; recognizing warning signs of employee violence; preventive action; and strategies for a safer library, including appropriate security systems and other devices. (LRW)

Consumer Health Information Provision in Rural Public Libraries: A Comparison of Two Library Systems

ERIC Educational Resources Information Center

Flaherty, Mary Grace

2013-01-01

To better understand health information provision in the public library setting, two cooperative library systems that serve primarily rural populations in upstate New York were studied. The central library in one of those systems established a consumer health information center (CHIC) in 1999. In the other system, the central library does not have…

A reliable computational workflow for the selection of optimal screening libraries.

PubMed

Gilad, Yocheved; Nadassy, Katalin; Senderowitz, Hanoch

2015-01-01

The experimental screening of compound collections is a common starting point in many drug discovery projects. Successes of such screening campaigns critically depend on the quality of the screened library. Many libraries are currently available from different vendors yet the selection of the optimal screening library for a specific project is challenging. We have devised a novel workflow for the rational selection of project-specific screening libraries. The workflow accepts as input a set of virtual candidate libraries and applies the following steps to each library: (1) data curation; (2) assessment of ADME/T profile; (3) assessment of the number of promiscuous binders/frequent HTS hitters; (4) assessment of internal diversity; (5) assessment of similarity to known active compound(s) (optional); (6) assessment of similarity to in-house or otherwise accessible compound collections (optional). For ADME/T profiling, Lipinski's and Veber's rule-based filters were implemented and a new blood brain barrier permeation model was developed and validated (85 and 74 % success rate for training set and test set, respectively). Diversity and similarity descriptors which demonstrated best performances in terms of their ability to select either diverse or focused sets of compounds from three databases (Drug Bank, CMC and CHEMBL) were identified and used for diversity and similarity assessments. The workflow was used to analyze nine common screening libraries available from six vendors. The results of this analysis are reported for each library providing an assessment of its quality. Furthermore, a consensus approach was developed to combine the results of these analyses into a single score for selecting the optimal library under different scenarios. We have devised and tested a new workflow for the rational selection of screening libraries under different scenarios. The current workflow was implemented using the Pipeline Pilot software yet due to the usage of generic components, it can be easily adapted and reproduced by computational groups interested in rational selection of screening libraries. Furthermore, the workflow could be readily modified to include additional components. This workflow has been routinely used in our laboratory for the selection of libraries in multiple projects and consistently selects libraries which are well balanced across multiple parameters.Graphical abstract.

Partnering with libraries to promote walking among community-dwelling adults: a Kingston gets active pilot pedometer-lending project.

PubMed

Ryder, Holly H; Faloon, Kathryn J; Lévesque, Lucie; McDonald, Deanna

2009-10-01

Most adults do not walk enough to obtain health benefits. Pedometers have been successfully utilized to motivate and increase walking. Given that libraries are a place where community members seek health resources, they are a logical setting for increasing community accessibility to pedometers. The purpose was to examine the feasibility of lending pedometers to library patrons to increase walking. In five Canadian public libraries, 90 pedometers were made available for 6 months. A total of 41 library patrons (33 women, 8 men, age range 18 to 65 or older) completed a survey about their walking patterns and pedometer use. More than 330 loans were made. Chisquare analysis found significant associations between walking and motivation to walk more (p < .05), walking and goal setting (p < .05), and motivation to walk more and setting a walking goal (p < .001). Results provide preliminary evidence that lending pedometers through local libraries is an effective, low-cost approach to enhance walking in community members.

Site-directed protein recombination as a shortest-path problem.

PubMed

Endelman, Jeffrey B; Silberg, Jonathan J; Wang, Zhen-Gang; Arnold, Frances H

2004-07-01

Protein function can be tuned using laboratory evolution, in which one rapidly searches through a library of proteins for the properties of interest. In site-directed recombination, n crossovers are chosen in an alignment of p parents to define a set of p(n + 1) peptide fragments. These fragments are then assembled combinatorially to create a library of p(n+1) proteins. We have developed a computational algorithm to enrich these libraries in folded proteins while maintaining an appropriate level of diversity for evolution. For a given set of parents, our algorithm selects crossovers that minimize the average energy of the library, subject to constraints on the length of each fragment. This problem is equivalent to finding the shortest path between nodes in a network, for which the global minimum can be found efficiently. Our algorithm has a running time of O(N(3)p(2) + N(2)n) for a protein of length N. Adjusting the constraints on fragment length generates a set of optimized libraries with varying degrees of diversity. By comparing these optima for different sets of parents, we rapidly determine which parents yield the lowest energy libraries.

Special Libraries and the Corporate Political Process.

ERIC Educational Resources Information Center

White, Herbert S.

1984-01-01

This examination of the position of the special library and its services in the corporate setting highlights reasons why libraries are often taken for granted, library's role in corporate financial calculations, generalizations concerning librarian characteristics, and situations that may indicate trouble for a library that is not serving its…

Concept of Price in a Library Context.

ERIC Educational Resources Information Center

Talaga, James A.

1991-01-01

Discusses pricing problems of public library service. The meaning of price in a library context is examined, including amount charged and patron's cost; components of price setting are described, including the impact of demand, cost, and competition; and library pricing strategies are suggested that should help achieve the library's goals. (13…

Getting Users to Library Resources: A Delicious Alternative

ERIC Educational Resources Information Center

Kapucu, Aysegul; Hoeppner, Athena; Dunlop, Doug

2008-01-01

The article gives an overview of social bookmarking in libraries and discusses the University of Central Florida (UCF) Libraries Delicious project and its outcomes in depth. It also addresses technical issues involved with setting up a library Delicious account; barriers to participation; training requirements; integration with other library sites…

Design of a general-purpose European compound screening library for EU-OPENSCREEN.

PubMed

Horvath, Dragos; Lisurek, Michael; Rupp, Bernd; Kühne, Ronald; Specker, Edgar; von Kries, Jens; Rognan, Didier; Andersson, C David; Almqvist, Fredrik; Elofsson, Mikael; Enqvist, Per-Anders; Gustavsson, Anna-Lena; Remez, Nikita; Mestres, Jordi; Marcou, Gilles; Varnek, Alexander; Hibert, Marcel; Quintana, Jordi; Frank, Ronald

2014-10-01

This work describes a collaborative effort to define and apply a protocol for the rational selection of a general-purpose screening library, to be used by the screening platforms affiliated with the EU-OPENSCREEN initiative. It is designed as a standard source of compounds for primary screening against novel biological targets, at the request of research partners. Given the general nature of the potential applications of this compound collection, the focus of the selection strategy lies on ensuring chemical stability, absence of reactive compounds, screening-compliant physicochemical properties, loose compliance to drug-likeness criteria (as drug design is a major, but not exclusive application), and maximal diversity/coverage of chemical space, aimed at providing hits for a wide spectrum of drugable targets. Finally, practical availability/cost issues cannot be avoided. The main goal of this publication is to inform potential future users of this library about its conception, sources, and characteristics. The outline of the selection procedure, notably of the filtering rules designed by a large committee of European medicinal chemists and chemoinformaticians, may be of general methodological interest for the screening/medicinal chemistry community. The selection task of 200K molecules out of a pre-filtered set of 1.4M candidates was shared by five independent European research groups, each picking a subset of 40K compounds according to their own in-house methodology and expertise. An in-depth analysis of chemical space coverage of the library serves not only to characterize the collection, but also to compare the various chemoinformatics-driven selection procedures of maximal diversity sets. Compound selections contributed by various participating groups were mapped onto general-purpose self-organizing maps (SOMs) built on the basis of marketed drugs and bioactive reference molecules. In this way, the occupancy of chemical space by the EU-OPENSCREEN library could be directly compared with distributions of known bioactives of various classes. This mapping highlights the relevance of the selection and shows how the consensus reached by merging the five different 40K selections contributes to achieve this relevance. The approach also allows one to readily identify subsets of target- or target-class-oriented compounds from the EU-OPENSCREEN library to suit the needs of the diverse range of potential users. The final EU-OPENSCREEN library, assembled by merging five independent selections of 40K compounds from various expert groups, represents an excellent example of a Europe-wide collaborative effort toward the common objective of building best-in-class European open screening platforms. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Library Services for Australia: The Work of AACOBS.

ERIC Educational Resources Information Center

National Library of Australia, Canberra.

Activities of the Australian Advisory Council on Bibliographical Services (AACOBS) in 1976 included a series of initiatives designed to promote, improve, and systematise the provision of library and information services on a nation-wide basis. This report discusses work in the area of (1) bibliographical services--work in progress, control of…

A Solution in Search of a Problem: Bibliometrics and Libraries.

ERIC Educational Resources Information Center

Wallace, Danny P.

1987-01-01

The literature of bibliometrics suggests that the results of bibliometric studies can be of practical use in libraries by providing a scientific basis for collection management decisions. Reports on the application of these studies are virtually nonexistent and a number of reasons for this are suggested. (EM)

Copyright in Context: The OCLC Database.

ERIC Educational Resources Information Center

Mason, Marilyn Gell

1988-01-01

Discusses topics related to OCLC adoption of guidelines for the use and transfer of OCLC-derived records, including the purpose of OCLC; the legal basis of copyrighting; technological change; compilation copyright; rationale for copyright of the OCLC database; impact on libraries; impact on networks; and relationships between OCLC and libraries. A…

Understanding the foundation: the state of generalist search education in library schools as related to the needs of expert searchers in medical libraries.

PubMed

Nicholson, Scott

2005-01-01

The paper explores the current state of generalist search education in library schools and considers that foundation in respect to the Medical Library Association's statement on expert searching. Syllabi from courses with significant searching components were examined from ten of the top library schools, as determined by the U.S. News & World Report rankings. Mixed methods were used, but primarily quantitative bibliometric methods were used. The educational focus in these searching components was on understanding the generalist searching resources and typical users and on performing a reflective search through application of search strategies, controlled vocabulary, and logic appropriate to the search tool. There is a growing emphasis on Web-based search tools and a movement away from traditional set-based searching and toward free-text search strategies. While a core set of authors is used in these courses, no core set of readings is used. While library schools provide a strong foundation, future medical librarians still need to take courses that introduce them to the resources, settings, and users associated with medical libraries. In addition, as more emphasis is placed on Web-based search tools and free-text searching, instructors of the specialist medical informatics courses will need to focus on teaching traditional search methods appropriate for common tools in the medical domain.

Context and learning: the value and limits of library-based information literacy teaching.

PubMed

Eyre, Jason

2012-12-01

This month's regular feature will discuss some of the implications for library-based information literacy teaching that have emerged from a HEA-funded research project conducted at De Montfort University. It is argued that information literacy teaching as it has evolved in a university setting, while having a greater degree of relevance and value than ever before, nevertheless has inherent limits when it comes to its transferability beyond the academy and into a workplace setting. © 2012 The authors. Health Information and Libraries Journal © 2012 Health Libraries Group.

A User’s Guide for LOGATAK. A Simulation Model to Analyze Logistic Network Distribution and Interdiction,

DTIC Science & Technology

1981-04-15

BLANK ADD LINK DATA TO LIBRARY 0 DELETE LINK DATA FROM LIBRARY C CHANGE ONE OR MORE VARIABLES OF DEFINED LINK IN LIBARY 25 ALTERATIONST...DELETE TERMINAL DATA FROM LIBRARY C CHANGE ONE OR MORE VARIABLES OF OEFINED TERMINAL IN LIBARY Unlike link data only one card is needed to change the...sector data cards identify the sets of data to be selected from the data library. Each data set is defined by a five digit number. The first four digits

From Rationale to Results: Implementing Performance Indicators in a Public Library.

ERIC Educational Resources Information Center

Alston, Ruth

This paper describes the theoretical design and practical implementation of a set of performance indicators in a public library system in London (England). Bromley Libraries has 15 branch libraries and serves 300,000 people. The need for improved management control by assessing performance and monitoring progress, library restructuring, and…

Sparse modeling applied to patient identification for safety in medical physics applications

NASA Astrophysics Data System (ADS)

Lewkowitz, Stephanie

Every scheduled treatment at a radiation therapy clinic involves a series of safety protocol to ensure the utmost patient care. Despite safety protocol, on a rare occasion an entirely preventable medical event, an accident, may occur. Delivering a treatment plan to the wrong patient is preventable, yet still is a clinically documented error. This research describes a computational method to identify patients with a novel machine learning technique to combat misadministration. The patient identification program stores face and fingerprint data for each patient. New, unlabeled data from those patients are categorized according to the library. The categorization of data by this face-fingerprint detector is accomplished with new machine learning algorithms based on Sparse Modeling that have already begun transforming the foundation of Computer Vision. Previous patient recognition software required special subroutines for faces and different tailored subroutines for fingerprints. In this research, the same exact model is used for both fingerprints and faces, without any additional subroutines and even without adjusting the two hyperparameters. Sparse modeling is a powerful tool, already shown utility in the areas of super-resolution, denoising, inpainting, demosaicing, and sub-nyquist sampling, i.e. compressed sensing. Sparse Modeling is possible because natural images are inherently sparse in some bases, due to their inherent structure. This research chooses datasets of face and fingerprint images to test the patient identification model. The model stores the images of each dataset as a basis (library). One image at a time is removed from the library, and is classified by a sparse code in terms of the remaining library. The Locally Competitive Algorithm, a truly neural inspired Artificial Neural Network, solves the computationally difficult task of finding the sparse code for the test image. The components of the sparse representation vector are summed by ℓ1 pooling, and correct patient identification is consistently achieved 100% over 1000 trials, when either the face data or fingerprint data are implemented as a classification basis. The algorithm gets 100% classification when faces and fingerprints are concatenated into multimodal datasets. This suggests that 100% patient identification will be achievable in the clinal setting.

Advances in Library Administration and Organization. Volume 16.

ERIC Educational Resources Information Center

Williams, Delmus E., Ed.; Garten, Edward D., Ed.

This book presents the following papers on library organizational and management issues: (1) "Knowledge Management: An Essential Framework for Corporate Library Leadership" (Deanna J. Streng); (2) "Critical Factors for Collaboration in an Academic Library Setting" (Charlotte M. Knoche); (3) "Salaries of Academic Librarians…

Radio-nuclide mixture identification using medium energy resolution detectors

DOEpatents

Nelson, Karl Einar

2013-09-17

According to one embodiment, a method for identifying radio-nuclides includes receiving spectral data, extracting a feature set from the spectral data comparable to a plurality of templates in a template library, and using a branch and bound method to determine a probable template match based on the feature set and templates in the template library. In another embodiment, a device for identifying unknown radio-nuclides includes a processor, a multi-channel analyzer, and a memory operatively coupled to the processor, the memory having computer readable code stored thereon. The computer readable code is configured, when executed by the processor, to receive spectral data, to extract a feature set from the spectral data comparable to a plurality of templates in a template library, and to use a branch and bound method to determine a probable template match based on the feature set and templates in the template library.

IFLA General Conference, 1990. Division of Libraries Serving the General Public: Section on Public Libraries; Section of Children's Libraries, Children's Literature Documentation Centres, Round Table; Section of School Libraries; Section of Libraries for the Blind; INTAMEL, Round Table; Mobile Libraries, Round Table. Booklet 3.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

The 28 papers in this collection were presented at meetings of four sections and three round tables within the Division of Libraries Serving the General Public: (1) "Rural Community Information Services: Guidelines for Researching Need, Setting Up Services and Evaluating Performance" (Elaine Kempson); (2) "Library Activities at the Workplace"…

Prototype of Multifunctional Full-text Library in the Architecture Web-browser / Web-server / SQL-server

NASA Astrophysics Data System (ADS)

Lyapin, Sergey; Kukovyakin, Alexey

Within the framework of the research program "Textaurus" an operational prototype of multifunctional library T-Libra v.4.1. has been created which makes it possible to carry out flexible parametrizable search within a full-text database. The information system is realized in the architecture Web-browser / Web-server / SQL-server. This allows to achieve an optimal combination of universality and efficiency of text processing, on the one hand, and convenience and minimization of expenses for an end user (due to applying of a standard Web-browser as a client application), on the other one. The following principles underlie the information system: a) multifunctionality, b) intelligence, c) multilingual primary texts and full-text searching, d) development of digital library (DL) by a user ("administrative client"), e) multi-platform working. A "library of concepts", i.e. a block of functional models of semantic (concept-oriented) searching, as well as a subsystem of parametrizable queries to a full-text database, which is closely connected with the "library", serve as a conceptual basis of multifunctionality and "intelligence" of the DL T-Libra v.4.1. An author's paragraph is a unit of full-text searching in the suggested technology. At that, the "logic" of an educational / scientific topic or a problem can be built in a multilevel flexible structure of a query and the "library of concepts", replenishable by the developers and experts. About 10 queries of various level of complexity and conceptuality are realized in the suggested version of the information system: from simple terminological searching (taking into account lexical and grammatical paradigms of Russian) to several kinds of explication of terminological fields and adjustable two-parameter thematic searching (a [set of terms] and a [distance between terms] within the limits of an author's paragraph are such parameters correspondingly).

Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens

PubMed Central

Hart, Traver; Tong, Amy Hin Yan; Chan, Katie; Van Leeuwen, Jolanda; Seetharaman, Ashwin; Aregger, Michael; Chandrashekhar, Megha; Hustedt, Nicole; Seth, Sahil; Noonan, Avery; Habsid, Andrea; Sizova, Olga; Nedyalkova, Lyudmila; Climie, Ryan; Tworzyanski, Leanne; Lawson, Keith; Sartori, Maria Augusta; Alibeh, Sabriyeh; Tieu, David; Masud, Sanna; Mero, Patricia; Weiss, Alexander; Brown, Kevin R.; Usaj, Matej; Billmann, Maximilian; Rahman, Mahfuzur; Costanzo, Michael; Myers, Chad L.; Andrews, Brenda J.; Boone, Charles; Durocher, Daniel; Moffat, Jason

2017-01-01

The adaptation of CRISPR/SpCas9 technology to mammalian cell lines is transforming the study of human functional genomics. Pooled libraries of CRISPR guide RNAs (gRNAs) targeting human protein-coding genes and encoded in viral vectors have been used to systematically create gene knockouts in a variety of human cancer and immortalized cell lines, in an effort to identify whether these knockouts cause cellular fitness defects. Previous work has shown that CRISPR screens are more sensitive and specific than pooled-library shRNA screens in similar assays, but currently there exists significant variability across CRISPR library designs and experimental protocols. In this study, we reanalyze 17 genome-scale knockout screens in human cell lines from three research groups, using three different genome-scale gRNA libraries. Using the Bayesian Analysis of Gene Essentiality algorithm to identify essential genes, we refine and expand our previously defined set of human core essential genes from 360 to 684 genes. We use this expanded set of reference core essential genes, CEG2, plus empirical data from six CRISPR knockout screens to guide the design of a sequence-optimized gRNA library, the Toronto KnockOut version 3.0 (TKOv3) library. We then demonstrate the high effectiveness of the library relative to reference sets of essential and nonessential genes, as well as other screens using similar approaches. The optimized TKOv3 library, combined with the CEG2 reference set, provide an efficient, highly optimized platform for performing and assessing gene knockout screens in human cell lines. PMID:28655737

Public Services and Outreach in Rare Book, Manuscript, and Special Collections Libraries.

ERIC Educational Resources Information Center

Traister, Daniel

2003-01-01

Discusses the new emphasis in special collections, especially in academic libraries, on the promotion of materials. Highlights include the economic basis of promotion; exhibitions; classroom ventures; the Web; seminars and other discussion groups; creative writing courses; one-time events; friends, tourists, and the public; and reference services.…

Regional Information Centers: A Frontier in Small Library Automation. Dissemination Document No. 12.

ERIC Educational Resources Information Center

Oldsen, Carl F.; Vinsonhaler, John F.

The regional information center is examined as an instrument for innovation in small library automation and as a basis for the evolution of national information systems. Summarized is development of regional information centers in education, including centers specially for handicapped children, and indicated are trends toward national information…

Library+

ERIC Educational Resources Information Center

Merrill, Alex

2011-01-01

This article discusses possible future directions for academic libraries in the post Web/Library 2.0 world. These possible directions include areas such as data literacy, linked data sets, and opportunities for libraries in support of digital humanities. The author provides a brief sketch of the background information regarding the topics and…

Computer Programs for Library Operations; Results of a Survey Conducted Between Fall 1971 and Spring 1972.

ERIC Educational Resources Information Center

Liberman, Eva; And Others

Many library operations involving large data banks lend themselves readily to computer operation. In setting up library computer programs, in changing or expanding programs, cost in programming and time delays could be substantially reduced if the programmers had access to library computer programs being used by other libraries, providing similar…

75 FR 63516 - Institute of Museum and Library Services; Sunshine Act Meeting of the National Museum and Library...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-15

... NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES Institute of Museum and Library Services; Sunshine Act Meeting of the National Museum and Library Services Board AGENCY: Institute of Museum and Library Services (IMLS), NFAH. ACTION: Notice of meeting. SUMMARY: This notice sets forth the agenda of...

The Value of Academic Libraries: Library Services as a Predictor of Student Retention

ERIC Educational Resources Information Center

Murray, Adam; Ireland, Ashley; Hackathorn, Jana

2016-01-01

This study examined the predictive relationship between library use by individual students and their retention status in university settings. The methodology builds on a small number of previous studies to examine library use at the individual level to determine if use of specific library services is predictive of retention for freshmen and…

Vignettes: diverse library staff offering diverse bioinformatics services*

PubMed Central

Osterbur, David L.; Alpi, Kristine; Canevari, Catharine; Corley, Pamela M.; Devare, Medha; Gaedeke, Nicola; Jacobs, Donna K.; Kirlew, Peter; Ohles, Janet A.; Vaughan, K.T.L.; Wang, Lili; Wu, Yongchun; Geer, Renata C.

2006-01-01

Objectives: The paper gives examples of the bioinformatics services provided in a variety of different libraries by librarians with a broad range of educational background and training. Methods: Two investigators sent an email inquiry to attendees of the “National Center for Biotechnology Information's (NCBI) Introduction to Molecular Biology Information Resources” or “NCBI Advanced Workshop for Bioinformatics Information Specialists (NAWBIS)” courses. The thirty-five-item questionnaire addressed areas such as educational background, library setting, types and numbers of users served, and bioinformatics training and support services provided. Answers were compiled into program vignettes. Discussion: The bioinformatics support services addressed in the paper are based in libraries with academic and clinical settings. Services have been established through different means: in collaboration with biology faculty as part of formal courses, through teaching workshops in the library, through one-on-one consultations, and by other methods. Librarians with backgrounds from art history to doctoral degrees in genetics have worked to establish these programs. Conclusion: Successful bioinformatics support programs can be established in libraries in a variety of different settings and by staff with a variety of different backgrounds and approaches. PMID:16888664

36 CFR 702.4 - Photographs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 702.4 Parks, Forests, and Public Property LIBRARY OF CONGRESS CONDUCT ON LIBRARY PREMISES § 702.4 Photographs. (a) The policy set out herein applies to all individuals who are photographing Library of... conditions may include provision for a fee for services rendered consistent with the Library's policies and...

Towards the discovery of drug-like RNA ligands?

PubMed

Foloppe, Nicolas; Matassova, Natalia; Aboul-Ela, Fareed

2006-11-01

Targeting RNA with small molecule drugs is an area of great potential for therapeutic treatment of infections and possibly genetic and autoimmune diseases. However, a mature set of precedents and established methodology is lacking. The physicochemical properties of RNA raise specific issues and obstacles to development, and contribute to explain the distinct characteristics of natural RNA ligands, including antibiotics. Yet, RNA-targeting strategies are being implemented to reinvigorate antibacterial discovery by using the ribosomal X-ray structures to modify known antibiotics. To exploit further these structures, we suggest the use of existing protein kinase-directed libraries of drug-like compounds to target the A-site of the bacterial ribosome, on the basis of a specific structural hypothesis.

Study of college library appealing information system: A case of Longyan University

NASA Astrophysics Data System (ADS)

Liao, Jin-Hui

2014-10-01

The complaints from the readers at university libraries mainly focus on the aspects of service attitude, quality of service, reading environment, the management system, etc. Librarians should realize that reader complaints can actually promote the role of the library service and communicate with readers who complain in a friendly manner. In addition, the Longyan University library should establish an internal management system, improve library hardware facilities, improve the quality of librarians and optimize the knowledge structure of librarians, so as to improve the quality of the service for readers and reduce complaints. Based on this point, we have designed an appealing information system in cryptography machine basis, to provide readers online, remote and anonymous complaint functions.

Software Helps Retrieve Information Relevant to the User

NASA Technical Reports Server (NTRS)

Mathe, Natalie; Chen, James

2003-01-01

The Adaptive Indexing and Retrieval Agent (ARNIE) is a code library, designed to be used by an application program, that assists human users in retrieving desired information in a hypertext setting. Using ARNIE, the program implements a computational model for interactively learning what information each human user considers relevant in context. The model, called a "relevance network," incrementally adapts retrieved information to users individual profiles on the basis of feedback from the users regarding specific queries. The model also generalizes such knowledge for subsequent derivation of relevant references for similar queries and profiles, thereby, assisting users in filtering information by relevance. ARNIE thus enables users to categorize and share information of interest in various contexts. ARNIE encodes the relevance and structure of information in a neural network dynamically configured with a genetic algorithm. ARNIE maintains an internal database, wherein it saves associations, and from which it returns associated items in response to a query. A C++ compiler for a platform on which ARNIE will be utilized is necessary for creating the ARNIE library but is not necessary for the execution of the software.

Using scientific evidence to improve information practice.

PubMed

Bradley, J; Marshall, J G

1995-09-01

The recent policy statement of the Medical Library Association (MLA) takes the position that scientific evidence is the basis for improving the quality of library and information sciences now and in the future. Research activity is seen as the foundation of an evolving knowledge base for the profession--a knowledge base that will set health sciences librarians apart from others in an increasingly competitive world of information service providers. The statement represents the culmination of many years of activity by association members, during which the role of research in health information practice has been debated. Over a similar time period, the quality movement, with its increasing demand for the collection and use of data, has been growing. Developments such as total quality management (TQM) and continuous quality improvement (CQI) reinforce the centrality of research with its increasing demand for the collection and use of data, has been growing. Developments such as total quality management (TQM) and continuous quality improvement (CQI) reinforce the centrality of research and its relationship to efficient and effective information practice as envisioned in the MLA policy statement.

Leading Edge Technologies in a Community College Library Setting: Identifying Disconnects of Academic Libraries and Their Users

ERIC Educational Resources Information Center

Stanley, Theresa C.

2010-01-01

The intent of this research was to discover what, if any, disconnect exists between community college students' library perceptions and technology use. The researcher studied how students at a very-large southwestern community college are using the physical and virtual college library, and their overall technology and library technology use. The…

Pop-up Library at the University of Birmingham: Extending the Reach of an Academic Library by Taking "The Library" to the Students

ERIC Educational Resources Information Center

Barnett, James; Bull, Stephen; Cooper, Helen

2016-01-01

Aligning with student engagement and promotional strategies, a Pop-Up Library project was initiated at the University of Birmingham. This involved setting up temporary, staffed stalls in different locations across campus in order to informally communicate with students and effectively take "the Library" to them. This article discusses…

A Dramaturgical Perspective on Academic Libraries

ERIC Educational Resources Information Center

Quinn, Brian

2005-01-01

Although many social sciences theories have been applied to the field of library and information science, one theory that has received relatively little attention is dramaturgy. The dramaturgical perspective posits that social life is inherently theatrical in nature. When applied to the academic library setting, both librarians and library users…

Leveraging Metadata to Create Better Web Services

ERIC Educational Resources Information Center

Mitchell, Erik

2012-01-01

Libraries have been increasingly concerned with data creation, management, and publication. This increase is partly driven by shifting metadata standards in libraries and partly by the growth of data and metadata repositories being managed by libraries. In order to manage these data sets, libraries are looking for new preservation and discovery…

Diversifying Fiscal Support by Pricing Public Library Services: A Policy Impact Analysis.

ERIC Educational Resources Information Center

Hicks, Donald A.

1980-01-01

Addresses the possibility of diversifying the resource base of public libraries dependent on property taxes for funding through the setting of fees for library services, and reports on a pricing policy adopted by the Dallas Public Library System. Twenty-seven references are cited. (FM)

Intellectual Freedom and Censorship in the Library

ERIC Educational Resources Information Center

Cooper, Jessica L.

2010-01-01

The article gives a brief description of intellectual freedom and censorship in order to set a foundation for looking into the library community's role in advocating for intellectual freedom and combating censorship. Focus is given to the unique challenges of school libraries in fulfilling the larger library community's expectations in these two…

LISPA (Library and Information Center Staff Planning Advisor): A Microcomputer-Based System.

ERIC Educational Resources Information Center

Devadason, F. J.; Vespry, H. A.

1996-01-01

Describes LISPA (Library and Information Center Staff Planning Advisor), a set of programs based on Ranganathan's staff plan model. LISPA particularly aids in planning for library staff requirements, both professional and paraprofessional, in developing countries where automated systems for other library operations are not yet available.…

Background Noise Acceptance and Personality Factors Involved in Library Environment Choices by College Students

ERIC Educational Resources Information Center

Gordon-Hickey, Susan; Lemley, Trey

2012-01-01

For decades, academic libraries made efforts to provide study environments differing in acoustic environment. The present study aimed to provide an evidence basis for this practice by comparing background noise acceptance and personality factors of two groups of college-aged students self identified as preferring quiet or background noise when…

Pima Community College Facilities Specification for a Library/Student Center Prototype. Final [Report].

ERIC Educational Resources Information Center

Paulien, Daniel K.; Thibodeau, Yvonne

This document is a description of a prototype Library/Student Center designed to serve approximately 10,000 students at a comprehensive campus. Prepared by the firm Paulien & Associates, Inc., of Denver, Colorado, this prototype will serve a design basis for facilities at all Pima Community College (PCC) campuses. The prototype will not be…

People First: A New Zealand Approach to Staff, Structure and Service

ERIC Educational Resources Information Center

Hill, Jane

2007-01-01

This article uses Wellington City Libraries as the basis for a case study of a future-focused, reorganized staffing structure in a public library network. It covers the change from why, how, departure from a building-based hierarchical structure, new staff and line responsibilities, union involvement, implications for staff training to culture and…

Annual Program; Library Services and Construction Act 1972-1973. Additional LSCA FY '73 Funds.

ERIC Educational Resources Information Center

South Carolina State Library, Columbia.

The South Carolina Annual Program, Library Services and Construction Act (LSCA), 1972-73, was originally developed on the basis of the funding level approved by the administration for 1973-74. Following court decisions on suits challenging impoundment of LSCA funds, additional monies became available under the act. This Supplement to the Annual…

MLS data segmentation using Point Cloud Library procedures. (Polish Title: Segmentacja danych MLS z użyciem procedur Point Cloud Library)

NASA Astrophysics Data System (ADS)

Grochocka, M.

2013-12-01

Mobile laser scanning is dynamically developing measurement technology, which is becoming increasingly widespread in acquiring three-dimensional spatial information. Continuous technical progress based on the use of new tools, technology development, and thus the use of existing resources in a better way, reveals new horizons of extensive use of MLS technology. Mobile laser scanning system is usually used for mapping linear objects, and in particular the inventory of roads, railways, bridges, shorelines, shafts, tunnels, and even geometrically complex urban spaces. The measurement is done from the perspective of use of the object, however, does not interfere with the possibilities of movement and work. This paper presents the initial results of the segmentation data acquired by the MLS. The data used in this work was obtained as part of an inventory measurement infrastructure railway line. Measurement of point clouds was carried out using a profile scanners installed on the railway platform. To process the data, the tools of 'open source' Point Cloud Library was used. These tools allow to use templates of programming libraries. PCL is an open, independent project, operating on a large scale for processing 2D/3D image and point clouds. Software PCL is released under the terms of the BSD license (Berkeley Software Distribution License), which means it is a free for commercial and research use. The article presents a number of issues related to the use of this software and its capabilities. Segmentation data is based on applying the templates library pcl_ segmentation, which contains the segmentation algorithms to separate clusters. These algorithms are best suited to the processing point clouds, consisting of a number of spatially isolated regions. Template library performs the extraction of the cluster based on the fit of the model by the consensus method samples for various parametric models (planes, cylinders, spheres, lines, etc.). Most of the mathematical operation is carried out on the basis of Eigen library, a set of templates for linear algebra.

The POPOP4 library and codes for preparing secondary gamma-ray production cross sections

NASA Technical Reports Server (NTRS)

Ford, W. E., III

1972-01-01

The POPOP4 code for converting secondary gamma ray yield data to multigroup secondary gamma ray production cross sections and the POPOP4 library of secondary gamma ray yield data are described. Recent results of the testing of uranium and iron data sets from the POPOP4 library are given. The data sets were tested by comparing calculated secondary gamma ray pulse height spectra measured at the ORNL TSR-II reactor.

After Katrina, Dismay and Recovery: Libraries Report the Extent of Damage as Library Community Continues to Mobilize

ERIC Educational Resources Information Center

Oder, Norman; Rogers, Michael

2005-01-01

The New Orleans Public Library (NOPL) is coming back from Hurricane Katrina--thanks to the State Library of Louisiana, NOPL in mid-September set up a temporary web site (nutrias.org). Unfortunately like many libraries in the Gulf region, it sustained significant damage and retained hope for renewal. This article reports the extent of damage…

Automated design of degenerate codon libraries.

PubMed

Mena, Marco A; Daugherty, Patrick S

2005-12-01

Degenerate codon libraries are frequently used in protein engineering and evolution studies but are often limited to targeting a small number of positions to adequately limit the search space. To mitigate this, codon degeneracy can be limited using heuristics or previous knowledge of the targeted positions. To automate design of libraries given a set of amino acid sequences, an algorithm (LibDesign) was developed that generates a set of possible degenerate codon libraries, their resulting size, and their score relative to a user-defined scoring function. A gene library of a specified size can then be constructed that is representative of the given amino acid distribution or that includes specific sequences or combinations thereof. LibDesign provides a new tool for automated design of high-quality protein libraries that more effectively harness existing sequence-structure information derived from multiple sequence alignment or computational protein design data.

The Special Challenges for National Libraries

ERIC Educational Resources Information Center

Breeding, Marshall

2011-01-01

Managing a library collection at the national level follows quite a different set of assumptions than hold for typical academic or public libraries. These collections, often comprehensive of all materials published in a country, press the limits of scale in terms of the sizes of collections. A national library collection might, for example, stand…

Automating Media Centers and Small Libraries: A Microcomputer-Based Approach.

ERIC Educational Resources Information Center

Meghabghab, Dania Bilal

Although the general automation process can be applied to most libraries, small libraries and media centers require a customized approach. Using a systematic approach, this guide covers each step and aspect of automation in a small library setting, and combines the principles of automation with field- tested activities. After discussing needs…

77 FR 68851 - Sunshine Act Meeting of the National Museum and Library Services Board

Federal Register 2010, 2011, 2012, 2013, 2014

2012-11-16

... NATIONAL FOUNDATION ON THE ARTS AND THE HUMANITIES Institute of Museum and Library Services Sunshine Act Meeting of the National Museum and Library Services Board AGENCY: Institute of Museum and Library Services (IMLS), NFAH. ACTION: Notice of meeting. SUMMARY: This notice sets forth the agenda of...

North Dakota Standards and Benchmarks--Content Standards: Library/Technology Literacy

ERIC Educational Resources Information Center

North Dakota Department of Public Instruction, 2003

2003-01-01

The Library/Technology Literacy Standards for the State of North Dakota were developed during 2000-2002 by a team of library and technology specialists, assisted by representatives from the Department of Public Instruction. The initial task was to decide whether technology and library curricula overlapped enough to create a shared set of…

7 CFR 505.3 - Fees for paper copying, duplicating, and reproduction of materials in library collections.

Code of Federal Regulations, 2011 CFR

2011-01-01

... of materials in library collections. 505.3 Section 505.3 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE NATIONAL AGRICULTURAL LIBRARY... in library collections. (a) Photocopy reproduction of paper copy will be set as a flat fee of $13.00...

7 CFR 505.3 - Fees for paper copying, duplicating, and reproduction of materials in library collections.

Code of Federal Regulations, 2012 CFR

2012-01-01

... of materials in library collections. 505.3 Section 505.3 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE NATIONAL AGRICULTURAL LIBRARY... in library collections. (a) Photocopy reproduction of paper copy will be set as a flat fee of $13.00...

7 CFR 505.3 - Fees for paper copying, duplicating, and reproduction of materials in library collections.

Code of Federal Regulations, 2010 CFR

2010-01-01

... of materials in library collections. 505.3 Section 505.3 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL RESEARCH SERVICE, DEPARTMENT OF AGRICULTURE NATIONAL AGRICULTURAL LIBRARY... in library collections. (a) Photocopy reproduction of paper copy will be set as a flat fee of $13.00...

Card-Sorting Usability Tests of the WMU Libraries' Web Site

ERIC Educational Resources Information Center

Whang, Michael

2008-01-01

This article describes the card-sorting techniques used by several academic libraries, reports and discusses the results of card-sorting usability tests of the Western Michigan University Libraries' Web site, and reveals how the WMU libraries incorporated the findings into a new Web site redesign, setting the design direction early on. The article…

A Framework for Studying Organizational Innovation in Research Libraries

ERIC Educational Resources Information Center

Jantz, Ronald C.

2012-01-01

The objective of this paper is two-fold: to propose a theoretical framework and model for studying organizational innovation in research libraries and to set forth propositions that can provide directions for future empirical studies of innovation in research libraries. Research libraries can be considered members of a class of organizations…

Can your public library improve your health and well-being? An investigation of East Sussex Library and Information Service.

PubMed

Ingham, Anneliese

2014-06-01

This article is only the second in the Dissertations into Practice series to highlight the role of public libraries in health information. It is the result of an investigation into the provision of health information in East Sussex Library and Information Service, which formed the basis of Anneliese Ingham's dissertation for her MA in Information Studies at the University of Brighton. At the time Anneliese was doing her research, the service was experimenting with different ways of providing healthcare information at one of its main libraries, and they were interested in the impact of this. The provision of health information to the public is one of my own research interests, and I was Anneliese's dissertation supervisor. I thought she produced a very good piece of work, and the results she highlights in this article are applicable to all public library authorities. Anneliese graduated with an MA in 2012 and worked for East Sussex Library and Information Service, which she joined whilst she was still studying. AM. © 2014 The authors. Health Information and Libraries Journal © 2014 Health Libraries Group.

Design of compound libraries for fragment screening

NASA Astrophysics Data System (ADS)

Blomberg, Niklas; Cosgrove, David A.; Kenny, Peter W.; Kolmodin, Karin

2009-08-01

Approaches to the design of libraries for fragment screening are illustrated with reference to a 20 k generic fragment screening library and a 1.2 k generic NMR screening library. Tools and methods for library design that have been developed within AstraZeneca are described, including Foyfi fingerprints and the Flush program for neighborhood characterization. It will be shown how Flush and the BigPicker, which selects maximally diverse sets of compounds, are used to apply the Core and Layer method for library design. Approaches to partitioning libraries into cocktails are also described.

HYPERDIRE-HYPERgeometric functions DIfferential REduction: Mathematica-based packages for the differential reduction of generalized hypergeometric functions: Lauricella function FC of three variables

NASA Astrophysics Data System (ADS)

Bytev, Vladimir V.; Kniehl, Bernd A.

2016-09-01

We present a further extension of the HYPERDIRE project, which is devoted to the creation of a set of Mathematica-based program packages for manipulations with Horn-type hypergeometric functions on the basis of differential equations. Specifically, we present the implementation of the differential reduction for the Lauricella function FC of three variables. Catalogue identifier: AEPP_v4_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEPP_v4_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: GNU General Public License, version 3 No. of lines in distributed program, including test data, etc.: 243461 No. of bytes in distributed program, including test data, etc.: 61610782 Distribution format: tar.gz Programming language: Mathematica. Computer: All computers running Mathematica. Operating system: Operating systems running Mathematica. Classification: 4.4. Does the new version supersede the previous version?: No, it significantly extends the previous version. Nature of problem: Reduction of hypergeometric function FC of three variables to a set of basis functions. Solution method: Differential reduction. Reasons for new version: The extension package allows the user to handle the Lauricella function FC of three variables. Summary of revisions: The previous version goes unchanged. Running time: Depends on the complexity of the problem.

"For Poor Nations a Library Service Is Vital": Establishing a National Public Library Service in Tanzania in the 1960s

ERIC Educational Resources Information Center

Olden, Anthony

2005-01-01

The Tanganyika Library Service (TLS) was the national public library service set up in Tanzania, East Africa, in the 1960s. By the end of the decade, it was generally regarded as a model of Western-style public library development in Africa. This is an account of its establishment and early years based on accessible documentary sources in Tanzania…

Challenges and Opportunities: A Report of the 1998 Library Survey of Internet Users at Seton Hall University.

ERIC Educational Resources Information Center

Bao, Xue-Ming

1998-01-01

A survey of 786 students and faculty found 78.6% used the World Wide Web on a daily or weekly basis and provided information about user demographics, frequency of use and satisfaction, search results and problems, university library home-page use, search strategies, and search training. Discusses challenges and opportunities for librarians…

Drugs and Drug-Like Compounds: Discriminating Approved Pharmaceuticals from Screening-Library Compounds

NASA Astrophysics Data System (ADS)

Schierz, Amanda C.; King, Ross D.

Compounds in drug screening-libraries should resemble pharmaceuticals. To operationally test this, we analysed the compounds in terms of known drug-like filters and developed a novel machine learning method to discriminate approved pharmaceuticals from “drug-like” compounds. This method uses both structural features and molecular properties for discrimination. The method has an estimated accuracy of 91% in discriminating between the Maybridge HitFinder library and approved pharmaceuticals, and 99% between the NATDiverse collection (from Analyticon Discovery) and approved pharmaceuticals. These results show that Lipinski’s Rule of 5 for oral absorption is not sufficient to describe “drug-likeness” and be the main basis of screening-library design.

Life in the Cloud: A WorldShare Management Services Case Study

ERIC Educational Resources Information Center

Hartman, Robin R.

2012-01-01

A small, private academic library took the risk of moving from a traditional integrated library system to adopting a system "in the cloud." This case study presents the setting, history, and local needs of the library, including staffing challenges, and explains the decision-making rationale and process. A description of the library's transition…

Globetrotting Students and Faculty: Adapting Library Instruction to Global Sites

ERIC Educational Resources Information Center

Solis, Eimmy; Perkins, Dan

2017-01-01

As e-resources become more ubiquitous, and the technologies available to access them more sophisticated, libraries have greater opportunities to reach out to global users. However, this same distance means that some users never even set foot in a physical library. This case study will describe how one large academic library started a business,…

Education and Outreach Programs at the Reagan Library.

ERIC Educational Resources Information Center

Cumming, Gregory G.

This exploration of the need and potential for education and outreach programs at the Reagan Library begins by examining factors that make the Reagan library unique, i.e., its proximity to Los Angeles and a small town setting, closeness to the Nixon Library and birthplace, and Ronald Reagan's popularity. It is noted that, since the Reagan Library…

Marketing & Libraries Do Mix: A Handbook for Libraries and Information Centers.

ERIC Educational Resources Information Center

Tenney, H. Baird; And Others

This handbook offers a practical set of ideas to help all types of libraries in the task of marketing their services in an increasingly competitive economy and provides a model program as urged by the White House Conference on Library and Information Services. It is aimed at adult information services in particular, with passing references to…

Guidelines for Public Library Service to Children in Vermont.

ERIC Educational Resources Information Center

1989

A task force was charged with developing a revised set of guidelines for public library service to children in Vermont. Together with the results of a survey of Vermont public libraries, the help of recommendations from other states, and the expertise of individual libraries, the task force drew up a number of guidelines. In the first section the…

Buoyant despite Downturn

ERIC Educational Resources Information Center

Berry, John N., III; Fialkoff, Francine; Fox, Bette-Lee; Hadro, Josh; Horrocks, Norman; Kuzyk, Raya; Oder, Norman

2009-01-01

Even as libraries face the economic downturn, a record-setting number of people attended the American Library Association (ALA) annual conference in Chicago, July 9-15. The tough economy, however, was felt in the number of exhibitors, which declined from the previous record set in 2007 in Washington, DC, and in anecdotal evidence that suggested…

Virtual Libraries: Meeting the Corporate Challenge.

ERIC Educational Resources Information Center

DiMattia, Susan S.; Blumenstein, Lynn C.

1999-01-01

Discusses virtual libraries in corporate settings from the viewpoint of five special librarians. Highlights include competitive advantage, space and related collection issues, the use of technology, corporate culture, information overload, library vulnerability and downsizing, and the importance of service over format. (LRW)

47 CFR 54.505 - Discounts.

Code of Federal Regulations, 2011 CFR

2011-10-01

... SERVICE Universal Service Support for Schools and Libraries § 54.505 Discounts. (a) Discount mechanism. Discounts for eligible schools and libraries shall be set as a percentage discount from the pre-discount price. (b) Discount percentages. The discounts available to eligible schools and libraries shall range...

47 CFR 54.505 - Discounts.

Code of Federal Regulations, 2012 CFR

2012-10-01

... SERVICE Universal Service Support for Schools and Libraries § 54.505 Discounts. (a) Discount mechanism. Discounts for eligible schools and libraries shall be set as a percentage discount from the pre-discount price. (b) Discount percentages. The discounts available to eligible schools and libraries shall range...

Private Dollar$ for Public Libraries.

ERIC Educational Resources Information Center

Krull, Jeffrey R.

1991-01-01

Proposes targeting individuals, corporations, and charitable foundations and trusts as a means of supplementing library fund-raising campaigns. The basics of establishing and maintaining a private funds foundation are addressed, including goal setting, personnel required, and nurturing the library's relationship with the community. A sidebar by…

DNA-encoded chemical libraries: advancing beyond conventional small-molecule libraries.

PubMed

Franzini, Raphael M; Neri, Dario; Scheuermann, Jörg

2014-04-15

DNA-encoded chemical libraries (DECLs) represent a promising tool in drug discovery. DECL technology allows the synthesis and screening of chemical libraries of unprecedented size at moderate costs. In analogy to phage-display technology, where large antibody libraries are displayed on the surface of filamentous phage and are genetically encoded in the phage genome, DECLs feature the display of individual small organic chemical moieties on DNA fragments serving as amplifiable identification barcodes. The DNA-tag facilitates the synthesis and allows the simultaneous screening of very large sets of compounds (up to billions of molecules), because the hit compounds can easily be identified and quantified by PCR-amplification of the DNA-barcode followed by high-throughput DNA sequencing. Several approaches have been used to generate DECLs, differing both in the methods used for library encoding and for the combinatorial assembly of chemical moieties. For example, DECLs can be used for fragment-based drug discovery, displaying a single molecule on DNA or two chemical moieties at the extremities of complementary DNA strands. DECLs can vary substantially in the chemical structures and the library size. While ultralarge libraries containing billions of compounds have been reported containing four or more sets of building blocks, also smaller libraries have been shown to be efficient for ligand discovery. In general, it has been found that the overall library size is a poor predictor for library performance and that the number and diversity of the building blocks are rather important indicators. Smaller libraries consisting of two to three sets of building blocks better fulfill the criteria of drug-likeness and often have higher quality. In this Account, we present advances in the DECL field from proof-of-principle studies to practical applications for drug discovery, both in industry and in academia. DECL technology can yield specific binders to a variety of target proteins and is likely to become a standard tool for pharmaceutical hit discovery, lead expansion, and Chemical Biology research. The introduction of new methodologies for library encoding and for compound synthesis in the presence of DNA is an exciting research field and will crucially contribute to the performance and the propagation of the technology.

Library Programming with LEGO MINDSTORMS, Scratch, and PicoCricket: Analysis of Best Practices for Public Libraries

ERIC Educational Resources Information Center

Romero, Juan Suarez

2010-01-01

Public libraries are redefining their roles in order to stay relevant to the needs of the communities they serve. Today, libraries are places where reading meets hands-on learning and where quietness coexists with voices and music. The latest advances in technology for children and teens, specifically, robotics sets and media-rich software, are…

Charting a Course through CORAL: Texas A&M University Libraries' Experience Implementing an Open-Source Electronic Resources Management System

ERIC Educational Resources Information Center

Hartnett, Eric; Beh, Eugenia; Resnick, Taryn; Ugaz, Ana; Tabacaru, Simona

2013-01-01

In 2010, after two previous unsuccessful attempts at electronic resources management system (ERMS) implementation, Texas A&M University (TAMU) Libraries set out once again to find an ERMS that would fit its needs. After surveying the field, TAMU Libraries selected the University of Notre Dame Hesburgh Libraries-developed, open-source ERMS,…

Successfully Automating Library Consortia: Procedures To Facilitate Governance, Management and Cooperation. DataResearch Automation Guide Series, Number Three.

ERIC Educational Resources Information Center

Data Research Associates, Inc., St. Louis, MO.

Sharing a local automated library system will generally reduce the costs of automation for each participating library and will facilitate the sharing of resources. To set up a consortium, libraries must first identify and agree on governance issues and methods for dealing with these issues. Issues range from ownership, management, and location of…

A Prototype System for a Computer-Based Statewide Film Library Network: A Model for Operation. Final Report.

ERIC Educational Resources Information Center

Bidwell, Charles M.; Auricchio, Dominick

The project set out to establish an operational film scheduling network to improve service to New York State teachers using 16mm educational films. The Network is designed to serve local libraries located in Boards of Cooperative Educational Services (BOCES), regional libraries, and a statewide Syracuse University Film Rental Library (SUFRL). The…

Roving Librarian: The Suitability of Tablets in Providing Personalized Help outside of the Traditional Library

ERIC Educational Resources Information Center

Sharman, Alison

2014-01-01

Emanating from the ground-breaking Library Impact Data Project, the aim of the Roving Librarian project first initiated in 2011 was to offer personalized help outside of the traditional library to library non-users in social or academic settings using Android and the iPad tablets. It was thought that the portability and flexibility of these…

U.S. Public Libraries and the Use of Web Technologies, 2012. A Closer Look

ERIC Educational Resources Information Center

Wanucha, Meghan; Hofschire, Linda

2013-01-01

In 2008, researchers at the Library Research Service (LRS) undertook the "U.S. Public Libraries and the Use of Web Technologies" study, with the intent to document the use of various Internet technologies on the websites of public libraries throughout the nation (Lietzau, 2009). The results of that study set a baseline for the adoption…

MpTheory Java library: a multi-platform Java library for systems biology based on the Metabolic P theory.

PubMed

Marchetti, Luca; Manca, Vincenzo

2015-04-15

MpTheory Java library is an open-source project collecting a set of objects and algorithms for modeling observed dynamics by means of the Metabolic P (MP) theory, that is, a mathematical theory introduced in 2004 for modeling biological dynamics. By means of the library, it is possible to model biological systems both at continuous and at discrete time. Moreover, the library comprises a set of regression algorithms for inferring MP models starting from time series of observations. To enhance the modeling experience, beside a pure Java usage, the library can be directly used within the most popular computing environments, such as MATLAB, GNU Octave, Mathematica and R. The library is open-source and licensed under the GNU Lesser General Public License (LGPL) Version 3.0. Source code, binaries and complete documentation are available at http://mptheory.scienze.univr.it. luca.marchetti@univr.it, marchetti@cosbi.eu Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Environmental modeling in data-sparse regions: Mozambique demonstrator case

NASA Astrophysics Data System (ADS)

Schumann, G.; Niebuhr, E.; Rashid, K.; Escobar, V. M.; Andreadis, K.; Njoku, E. G.; Neal, J. C.; Voisin, N.; Pappenberger, F.; Phanthuwongpakdee, N.; Bates, P. D.; Chao, Y.; Moller, D.; Paron, P.

2014-12-01

Long time-series computations of seasonal and flood event inundation volumes from archived forecast rainfall events for the Lower Zambezi basin (Mozambique), using a coupled hydrology-hydrodynamic model, are correlated and regressed with satellite soil moisture observations and NWP rainfall forecasts as predictors for inundation volumes. This dynamic library of volume predictions can then be re-projected onto the topography to generate the corresponding floodplain and wetland inundation dynamics, including periods of flood and low flows. Especially for data-poor regions, the application potential of such a library of data is invaluable as the modeling chain is greatly simplified and readily available. The library is flexible, portable and transitional. Furthermore, deriving environmental indicators from this dynamic look-up catalogue would be relatively straightforward. Application fields are various and here we present conceptually a few that we plan to research in more detail and on some of which we already collaborate with other scientists and international institutions, though at the moment largely on an unfunded basis. The primary application is to implement an early warning system for flood inundation relief operations and flood inundation mitigation and resilience. Having this flood inundation warning system set up adequately would also allow looking into long-term predictions of crop productivity and consequently food security. Another potentially high-impact application is to relate flood inundation dynamics to disease modeling for public health monitoring and prediction, in particular focusing on Malaria. Last but not least, the dynamic inundation library we are building can be validated and complemented with advanced airborne radar imagery of flooding and inundated wetlands to study changes in wetland ecology and biodiversity with unprecedented detail in data-poor regions, in this case in particular the important wetlands of the Zambezi Delta.

Destination Media Center: How to Provide an Orientation to Make Sure Patrons Are Headed in the Right Direction

ERIC Educational Resources Information Center

Purcell, Melissa

2011-01-01

The school library media center should be a place that every student and teacher feels compelled to visit on a daily basis. Offering good, informative orientations can provide the direction needed to ensure that happens. Orientations should be part of every school library media specialist's job description and role. Orientations can be as long or…

Catch Them Young: Developing and Improving of School Libraries and Reading Habit of Secondary School Students in Nigeria

ERIC Educational Resources Information Center

Oriogu, Chuks Daniel

2015-01-01

Reading habit is a fundamental skill necessary in the life of every student. It is essential in developing a more civilized and knowledgeable society. Therefore, the study investigated reading habit of secondary school students and ways of developing and improving of school libraries in Nigeria. The study reviewed the basis of reading skills,…

A Study of Periodical Literature Searching at an Urban Research Library: Problems and Patterns.

ERIC Educational Resources Information Center

Carey, Kevin

Patron use of periodical indexes at an urban academic research library was studied over a 7-week period in the summer of 1982. A total of 98 patrons were interviewed on a random basis as they used various periodical and newspaper indexes. The questionnaire was designed to gather information on citation elements, the methods patrons use to locate…

Capacity Building and Sustainment: Focusing on the End-State for Homeland Security

DTIC Science & Technology

2007-03-01

Basic Writings of John Stuart Mill : On Liberty, The Subjection of Women & Utilitarianism (New York: The Modern Library, 2002), 234. 297 Council on...Writings of John Stuart Mill : On Liberty, The Subjection of Women & Utilitarianism . New York: The Modern Library, 2002. Palmer, Robert R., Bell I...and the basis for capacity development. Prioritizing development needs 296 John Stuart Mill , The

Do We Still Need Controlled Vocabulary? Of Course, We Do! But How Do We Get It: The Roles for Text Analysis Softwares.

ERIC Educational Resources Information Center

Greenfield, Rich

The author argues that traditional library cataloging (MARC) and the online public access catalog (OPAC) are in collision with the world of the Internet because items in electronic formats undergo MARC cataloging only on a very selective basis. Also the library profession initially isolated itself from World Wide Web development by predicting no…

An Array Library for Microsoft SQL Server with Astrophysical Applications

NASA Astrophysics Data System (ADS)

Dobos, L.; Szalay, A. S.; Blakeley, J.; Falck, B.; Budavári, T.; Csabai, I.

2012-09-01

Today's scientific simulations produce output on the 10-100 TB scale. This unprecedented amount of data requires data handling techniques that are beyond what is used for ordinary files. Relational database systems have been successfully used to store and process scientific data, but the new requirements constantly generate new challenges. Moving terabytes of data among servers on a timely basis is a tough problem, even with the newest high-throughput networks. Thus, moving the computations as close to the data as possible and minimizing the client-server overhead are absolutely necessary. At least data subsetting and preprocessing have to be done inside the server process. Out of the box commercial database systems perform very well in scientific applications from the prospective of data storage optimization, data retrieval, and memory management but lack basic functionality like handling scientific data structures or enabling advanced math inside the database server. The most important gap in Microsoft SQL Server is the lack of a native array data type. Fortunately, the technology exists to extend the database server with custom-written code that enables us to address these problems. We present the prototype of a custom-built extension to Microsoft SQL Server that adds array handling functionality to the database system. With our Array Library, fix-sized arrays of all basic numeric data types can be created and manipulated efficiently. Also, the library is designed to be able to be seamlessly integrated with the most common math libraries, such as BLAS, LAPACK, FFTW, etc. With the help of these libraries, complex operations, such as matrix inversions or Fourier transformations, can be done on-the-fly, from SQL code, inside the database server process. We are currently testing the prototype with two different scientific data sets: The Indra cosmological simulation will use it to store particle and density data from N-body simulations, and the Milky Way Laboratory project will use it to store galaxy simulation data.

The two-electron atomic systems. S-states

NASA Astrophysics Data System (ADS)

Liverts, Evgeny Z.; Barnea, Nir

2010-01-01

A simple Mathematica program for computing the S-state energies and wave functions of two-electron (helium-like) atoms (ions) is presented. The well-known method of projecting the Schrödinger equation onto the finite subspace of basis functions was applied. The basis functions are composed of the exponentials combined with integer powers of the simplest perimetric coordinates. No special subroutines were used, only built-in objects supported by Mathematica. The accuracy of results and computation time depend on the basis size. The precise energy values of 7-8 significant figures along with the corresponding wave functions can be computed on a single processor within a few minutes. The resultant wave functions have a simple analytical form consisting of elementary functions, that enables one to calculate the expectation values of arbitrary physical operators without any difficulties. Program summaryProgram title: TwoElAtom-S Catalogue identifier: AEFK_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEFK_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 10 185 No. of bytes in distributed program, including test data, etc.: 495 164 Distribution format: tar.gz Programming language: Mathematica 6.0; 7.0 Computer: Any PC Operating system: Any which supports Mathematica; tested under Microsoft Windows XP and Linux SUSE 11.0 RAM:⩾10 bytes Classification: 2.1, 2.2, 2.7, 2.9 Nature of problem: The Schrödinger equation for atoms (ions) with more than one electron has not been solved analytically. Approximate methods must be applied in order to obtain the wave functions or other physical attributes from quantum mechanical calculations. Solution method: The S-wave function is expanded into a triple basis set in three perimetric coordinates. Method of projecting the two-electron Schrödinger equation (for atoms/ions) onto a subspace of the basis functions enables one to obtain the set of homogeneous linear equations F.C=0 for the coefficients C of the above expansion. The roots of equation det(F)=0 yield the bound energies. Restrictions: First, the too large length of expansion (basis size) takes the too large computation time giving no perceptible improvement in accuracy. Second, the order of polynomial Ω (input parameter) in the wave function expansion enables one to calculate the excited nS-states up to n=Ω+1 inclusive. Additional comments: The CPC Program Library includes "A program to calculate the eigenfunctions of the random phase approximation for two electron systems" (AAJD). It should be emphasized that this fortran code realizes a very rough approximation describing only the averaged electron density of the two electron systems. It does not characterize the properties of the individual electrons and has a number of input parameters including the Roothaan orbitals. Running time: ˜10 minutes (depends on basis size and computer speed)

Leadership in Libraries--Feedback as Communication.

ERIC Educational Resources Information Center

Wright, Dianne H.

This paper focuses on the role of feedback in effective communication and ways in which feedback can assist library managers at all levels in performing their role as leaders. The various kinds and sources of feedback are discussed, and the relationship between feedback and goal setting are considered, as well as the effects of goal setting and…

36 CFR 703.2 - Policy.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Availability of Library of Congress Records § 703.2 Policy. (a) Subject to limitations set out in this part, Library of Congress records shall be available as hereinafter provided and shall be...

36 CFR 703.2 - Policy.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Availability of Library of Congress Records § 703.2 Policy. (a) Subject to limitations set out in this part, Library of Congress records shall be available as hereinafter provided and shall be...

36 CFR 703.2 - Policy.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Availability of Library of Congress Records § 703.2 Policy. (a) Subject to limitations set out in this part, Library of Congress records shall be available as hereinafter provided and shall be...

Organizational Influences on the University Electronic Library.

ERIC Educational Resources Information Center

Davies, Clare

1997-01-01

Reviews the literature on the development of full-text electronic libraries in the academic setting. Organizational factors can have impact on electronic library development and ultimate usability. Topics include strategic management, planning and implementation; system specification and design; document provision; user support and training; and…

Peroxisome Mini-Libraries: Systematic Approaches to Study Peroxisomes Made Easy.

PubMed

Dahan, Noa; Schuldiner, Maya; Zalckvar, Einat

2017-01-01

High-throughput methodologies have been extensively used in the budding yeast, Saccharomyces cerevisiae, to uncover fundamental principles of cell biology. Over the years, several collections of yeast strains (libraries) were built to enable systematic exploration of cellular functions. However, using these libraries experimentally is often labor intensive and restricted to laboratories that hold high throughput platforms. Utilizing the available full genome libraries we handpicked a subset of strains that represent all known and predicted peroxisomal proteins as well as proteins that have central roles in peroxisome biology. These smaller collections of strains, mini-libraries, can be rapidly and easily used for complicated screens by any lab. Since one of the libraries is built such that it can be easily modified in the tag, promoter and selection, we also discuss how these collections form the basis for creating a diversity of new peroxisomal libraries for future studies. Using manual tools, available in any yeast lab, coupled with few simple genetic approaches, we will show how these libraries can be "mixed and matched" to create tailor made libraries for screening. These yeast collections may now be exploited to study uncharted territories in the biology of peroxisomes by anyone, anywhere.

Human Aspects of Library Automation: Helping Staff and Patrons Cope. Papers presented at the Annual Clinic on Library Applications of Data Processing (22nd, Urbana, Illinois, April 14-16, 1985).

ERIC Educational Resources Information Center

Shaw, Debora, Ed.

This collection explores the human aspect of the automation and reautomation of library functions as both library staff and library users are expected to adapt to and use computers. A brief introduction by Debora Shaw sets the stage for the following papers: (1) "Terminal Paralysis, or Showdown at the Interface" (Sara Fine); (2)…

The visible human male: a technical report.

PubMed Central

Spitzer, V; Ackerman, M J; Scherzinger, A L; Whitlock, D

1996-01-01

The National Library of Medicine's Visible Human Male data set consists of digital magnetic resonance (MR), computed tomography (CT), and anatomic images derived from a single male cadaver. The data set is 15 gigabytes in size and is available from the National Library of Medicine under a no-cost license agreement. The history of the Visible Human Male cadaver and the methods and technology to produce the data set are described. PMID:8653448

A Model for Designing Library Instruction for Distance Learning

ERIC Educational Resources Information Center

Rand, Angela Doucet

2013-01-01

Providing library instruction in distance learning environments presents a unique set of challenges for instructional librarians. Innovations in computer-mediated communication and advances in cognitive science research provide the opportunity for designing library instruction that meets a variety of student information seeking needs. Using a…

Identify Your Brand, Before You Market.

ERIC Educational Resources Information Center

Claggett, Laura

2002-01-01

Discusses marketing in special libraries and suggests that librarians need to identify library services that set them apart from others. Highlights include the competitive environment and alternatives for the consumer; value that the library offers; targeting consumers; return on investment; and determining why consumers choose your services. (LRW)

A PVS Graph Theory Library

NASA Technical Reports Server (NTRS)

Butler, Ricky W.; Sjogren, Jon A.

1998-01-01

This paper documents the NASA Langley PVS graph theory library. The library provides fundamental definitions for graphs, subgraphs, walks, paths, subgraphs generated by walks, trees, cycles, degree, separating sets, and four notions of connectedness. Theorems provided include Ramsey's and Menger's and the equivalence of all four notions of connectedness.

Librarians' Attitudes towards Marketing Library Services

ERIC Educational Resources Information Center

Aharony, Noa

2009-01-01

This research set out to explore the attitudes of school, academic and public librarians towards marketing libraries. The main question that was examined is whether personality characteristics such as empowerment, extroversion and resistance to change influence librarians' attitudes towards the marketing of libraries. One hundred and fifty-six…

A Circle of Colleagues Meet in the Loop: ALA Midwinter Report.

ERIC Educational Resources Information Center

Wilson Library Bulletin, 1987

1987-01-01

Highlights the American Library Association (ALA) 1987 Midwinter Conference, including the aftermath of the Attorney General's report on pornography; Congressional pay equity bills; library copying rights; federal librarians' decline in membership and privatization; public library planning, role setting, and output measures manuals; and summaries…

A Guide for Montana School Libraries; A Manual of Basic Library Procedures for Montana Schools, Developed by Montana Teachers and Librarians.

ERIC Educational Resources Information Center

Montana State Dept. of Public Instruction, Helena.

Basic procedures for setting up a new school library or for maintaining an established one are described to help economize the librarian's efforts and assist in establishing effective organization. Use of this guide to streamline library routine will give librarians more time to assist school personnel and to develop a better total library…

Transcending Library Catalogs: A Comparative Study of Controlled Terms in Library of Congress Subject Headings and User-Generated Tags in LibraryThing for Transgender Books

ERIC Educational Resources Information Center

Adler, Melissa

2009-01-01

Perhaps the greatest power of folksonomies, especially when set against controlled vocabularies like the Library of Congress Subject Headings, lies in their capacity to empower user communities to name their own resources in their own terms. This article analyzes the potential and limitations of both folksonomies and controlled vocabularies for…

Rethinking the Library in the Information Age. Volume III. Building an Infrastructure for Library Research.

ERIC Educational Resources Information Center

Mathews, Anne J., Ed.

This report is the third in a set of three reports from the project, "Issues in Library Research: Proposals for the 1990s," which was launched in September 1986 to investigate library and information science issues in order to assess the current state of the profession and identify a research agenda to lead into the next decade. This…

How To Use a Library. Power of the Printed Word.

ERIC Educational Resources Information Center

Michener, James A.

To make the most of a library, read and read and read. Here's a sure remedy for the television habit: pile a stack of library books on the television set and next time, instead of turning on a program, reach for a book. Some people limit themselves to reading current bestsellers, but the library is full of yesterday's bestsellers which are still…

The ergonomics/human factors approach to health sciences libraries.

PubMed Central

Bube, J L

1985-01-01

A review of the literature reveals scant information on the application of ergonomics to health sciences libraries. Ergonomics research has identified and validated many genuine health hazards in business offices and industrial settings. While appearing innocuous, the library environment is affected by these hazards. As sophisticated technology and machinery are introduced into libraries, the human factors must be considered. This paper examines the hazards of the library environment as identified through ergonomics research and makes recommendations for alleviating or eliminating these dangers. PMID:3161572

Gwyscan: a library to support non-equidistant scanning probe microscope measurements

NASA Astrophysics Data System (ADS)

Klapetek, Petr; Yacoot, Andrew; Grolich, Petr; Valtr, Miroslav; Nečas, David

2017-03-01

We present a software library and related methodology for enabling easy integration of adaptive step (non-equidistant) scanning techniques into metrological scanning probe microscopes or scanning probe microscopes where individual x, y position data are recorded during measurements. Scanning with adaptive steps can reduce the amount of data collected in SPM measurements thereby leading to faster data acquisition, a smaller amount of data collection required for a specific analytical task and less sensitivity to mechanical and thermal drift. Implementation of adaptive scanning routines into a custom built microscope is not normally an easy task: regular data are much easier to handle for previewing (e.g. levelling) and storage. We present an environment to make implementation of adaptive scanning easier for an instrument developer, specifically taking into account data acquisition approaches that are used in high accuracy microscopes as those developed by National Metrology Institutes. This includes a library with algorithms written in C and LabVIEW for handling data storage, regular mesh preview generation and planning the scan path on basis of different assumptions. A set of modules for Gwyddion open source software for handling these data and for their further analysis is presented. Using this combination of data acquisition and processing tools one can implement adaptive scanning in a relatively easy way into an instrument that was previously measuring on a regular grid. The performance of the presented approach is shown and general non-equidistant data processing steps are discussed.

Effects of Flexitime on Sick Leave, Vacation Leave, Anxiety, Performance, and Satisfaction in a Library Setting.

ERIC Educational Resources Information Center

Saunders, Carol Stoak; Saunders, Russell

1985-01-01

Results of study using pretest and posttest control group design in public university library setting to study impact of flexitime indicate that: satisfaction with promotions decreased with significant effect, sick leaves decreased, average length of vacation leaves increased, and results were mixed on performance and approached significance for…

Informatic selection of a neural crest-melanocyte cDNA set for microarray analysis

PubMed Central

Loftus, S. K.; Chen, Y.; Gooden, G.; Ryan, J. F.; Birznieks, G.; Hilliard, M.; Baxevanis, A. D.; Bittner, M.; Meltzer, P.; Trent, J.; Pavan, W.

1999-01-01

With cDNA microarrays, it is now possible to compare the expression of many genes simultaneously. To maximize the likelihood of finding genes whose expression is altered under the experimental conditions, it would be advantageous to be able to select clones for tissue-appropriate cDNA sets. We have taken advantage of the extensive sequence information in the dbEST expressed sequence tag (EST) database to identify a neural crest-derived melanocyte cDNA set for microarray analysis. Analysis of characterized genes with dbEST identified one library that contained ESTs representing 21 neural crest-expressed genes (library 198). The distribution of the ESTs corresponding to these genes was biased toward being derived from library 198. This is in contrast to the EST distribution profile for a set of control genes, characterized to be more ubiquitously expressed in multiple tissues (P < 1 × 10−9). From library 198, a subset of 852 clustered ESTs were selected that have a library distribution profile similar to that of the 21 neural crest-expressed genes. Microarray analysis demonstrated the majority of the neural crest-selected 852 ESTs (Mel1 array) were differentially expressed in melanoma cell lines compared with a non-neural crest kidney epithelial cell line (P < 1 × 10−8). This was not observed with an array of 1,238 ESTs that was selected without library origin bias (P = 0.204). This study presents an approach for selecting tissue-appropriate cDNAs that can be used to examine the expression profiles of developmental processes and diseases. PMID:10430933

Advanced Spectral Library (ASTRAL): Atomic Fluorescence in Cool, Evolved Stars

NASA Astrophysics Data System (ADS)

Carpenter, Ken G.; Nielsen, Krister E.; Kober, Gladys V.; Rau, Gioia

2018-01-01

The "Advanced Spectral Library (ASTRAL) Project: Cool Stars" (PI = T. Ayres) collected a definitive set of representative, high-resolution (R~46,000 in the FUV up to ~1700 Å, R~30,000 for 1700-2150 Å, and R~114,000 >2150 Å) and high signal/noise (S/N>100) UV spectra of eight F-M evolved cool stars. These extremely high-quality STIS UV echelle spectra are available from the HST archive and from the Univ. of Colorado (http://casa.colorado.edu/~ayres/ASTRAL/) and will enable investigations of a broad range of problems -- stellar, interstellar, and beyond -- for many years. In this paper, we extend our study of the very rich emission-line spectra of the four evolved K-M stars in the sample, Beta Gem (K0 IIIb), Gamma Dra (K5 III), Gamma Cru (M3.4 III), and Alpha Ori (M2 Iab), to study the atomic fluorescence processes operating in their outer atmospheres. We summarize the pumping transitions and fluorescent line products known on the basis of previous work (e.g. Carpenter 1988, etc.) and newly identified in our current, on-going analysis of these extraordinary ASTRAL STIS spectra.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marleau, Peter; Monterial, Mateusz; Clarke, Shaun

A Bayesian approach is proposed for pulse shape discrimination of photons and neutrons in liquid organic scinitillators. Instead of drawing a decision boundary, each pulse is assigned a photon or neutron confidence probability. In addition, this allows for photon and neutron classification on an event-by-event basis. The sum of those confidence probabilities is used to estimate the number of photon and neutron instances in the data. An iterative scheme, similar to an expectation-maximization algorithm for Gaussian mixtures, is used to infer the ratio of photons-to-neutrons in each measurement. Therefore, the probability space adapts to data with varying photon-to-neutron ratios. Amore » time-correlated measurement of Am–Be and separate measurements of 137Cs, 60Co and 232Th photon sources were used to construct libraries of neutrons and photons. These libraries were then used to produce synthetic data sets with varying ratios of photons-to-neutrons. Probability weighted method that we implemented was found to maintain neutron acceptance rate of up to 90% up to photon-to-neutron ratio of 2000, and performed 9% better than the decision boundary approach. Furthermore, the iterative approach appropriately changed the probability space with an increasing number of photons which kept the neutron population estimate from unrealistically increasing.« less

75 FR 44800 - National Library of Medicine; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-29

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health National Library of Medicine... meeting will be open to the public as indicated below, with attendance limited to space available... National Library of Medicine will be closed to the public in accordance with the provisions set forth in...

Library Statistical Data Base Formats and Definitions.

ERIC Educational Resources Information Center

Jones, Dennis; And Others

Represented are the detailed set of data structures relevant to the categorization of information, terminology, and definitions employed in the design of the library statistical data base. The data base, or management information system, provides administrators with a framework of information and standardized data for library management, planning,…

The Roles of Libraries in Education.

ERIC Educational Resources Information Center

Boucher, Julie J.; Lance, Keith Curry

Three sets of roles that libraries play in education are identified. Each of the roles is explained, accompanied by relevant statistics and examples. In the first place, libraries provide access to education by teaching information skills, by providing leadership and expertise in the use of information and information technologies, and by…

A Mobile Application for Discovery

ERIC Educational Resources Information Center

Zylstra, Robert

2011-01-01

The last 5 years have heralded a number of important changes to virtual libraries in academic and public settings. Despite this continual effort to improve library catalogs and websites, the fundamentals of these online spaces remain relatively unchanged. Digital collections are within reach of many libraries, yet they remain difficult to…

36 CFR § 703.2 - Policy.

Code of Federal Regulations, 2013 CFR

2013-07-01

...§ 703.2 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Availability of Library of Congress Records § 703.2 Policy. (a) Subject to limitations set out in this part, Library of Congress records shall be available as hereinafter provided and shall be...

Basic Components of a Public Library Collection Development Policy.

ERIC Educational Resources Information Center

Maryland Library Association, Baltimore.

This booklet outlines the components of public library collection development policies and presents a set of materials which address the civil issues surrounding the freedom of public libraries to maintain uncensored collections. An introduction which defines the function of collection development policies is followed by an outline of the basic…

Putting the Medical Library Online: Electronic Bulletin Boards. . . and Beyond.

ERIC Educational Resources Information Center

Kittle, Paul W.

1985-01-01

Describes use of microcomputers with system called "TBBS" ("The Bread Board System") at Loma Linda University Medical Center to allow users enhanced services from home, whether library facilities are open or not. Flexibility and security, dialing into medical library, and suggestions for setting up similar computerized…

Collection Evaluation and Acquisition Budgets: A Kaleidoscope in the Making.

ERIC Educational Resources Information Center

Osburn, Charles B.

1992-01-01

Discusses library collection evaluation and its relationship to the acquisitions budget. Topics addressed include the publishing industry; library services that are more user centered; acquisition of versus access to sources of information and knowledge; the concept of value; library accountability; objectives and setting priorities; and levels of…

A standard library for modeling satellite orbits on a microcomputer

NASA Astrophysics Data System (ADS)

Beutel, Kenneth L.

1988-03-01

Introductory students of astrodynamics and the space environment are required to have a fundamental understanding of the kinematic behavior of satellite orbits. This thesis develops a standard library that contains the basic formulas for modeling earth orbiting satellites. This library is used as a basis for implementing a satellite motion simulator that can be used to demonstrate orbital phenomena in the classroom. Surveyed are the equations of orbital elements, coordinate systems and analytic formulas, which are made into a standard method for modeling earth orbiting satellites. The standard library is written in the C programming language and is designed to be highly portable between a variety of computer environments. The simulation draws heavily on the standards established by the library to produce a graphics-based orbit simulation program written for the Apple Macintosh computer. The simulation demonstrates the utility of the standard library functions but, because of its extensive use of the Macintosh user interface, is not portable to other operating systems.

Educational services in health sciences libraries: an analysis of the periodical literature, 1975-1986.

PubMed Central

Zachert, M J

1987-01-01

The periodical literature on group instructional services in health sciences libraries was analyzed to determine the nature of these services, their target audiences, and their institutional settings. Three kinds of reports were identified: descriptions of services (70%), reviews of the literature (10.5%), and future-oriented articles that advocate various group instructional services (19.5%). Five target audiences were identified: library users, staff, librarian peers, library science students, and patients. Instructional services were offered primarily in medical school/center libraries, hospital libraries, and the National Library of Medicine and its Regional Medical Libraries (RMLs). To a lesser extent, health sciences educational services are offered through other professional school libraries, library associations and consortia, and schools of library science. There are gaps in the literature in the areas of library experience with marketing, evaluation, administration of the offered educational services, and continuing education for health sciences librarians. PMID:3676534

Educational services in health sciences libraries: an analysis of the periodical literature, 1975-1986.

PubMed

Zachert, M J

1987-07-01

The periodical literature on group instructional services in health sciences libraries was analyzed to determine the nature of these services, their target audiences, and their institutional settings. Three kinds of reports were identified: descriptions of services (70%), reviews of the literature (10.5%), and future-oriented articles that advocate various group instructional services (19.5%). Five target audiences were identified: library users, staff, librarian peers, library science students, and patients. Instructional services were offered primarily in medical school/center libraries, hospital libraries, and the National Library of Medicine and its Regional Medical Libraries (RMLs). To a lesser extent, health sciences educational services are offered through other professional school libraries, library associations and consortia, and schools of library science. There are gaps in the literature in the areas of library experience with marketing, evaluation, administration of the offered educational services, and continuing education for health sciences librarians.

Production and Testing of the VITAMIN-B7 Fine-Group and BUGLE-B7 Broad-Group Coupled Neutron/Gamma Cross-Section Libraries Derived from ENDF/B-VII.0 Nuclear Data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Risner, J. M.; Wiarda, D.; Dunn, M. E.

2011-09-30

New coupled neutron-gamma cross-section libraries have been developed for use in light water reactor (LWR) shielding applications, including pressure vessel dosimetry calculations. The libraries, which were generated using Evaluated Nuclear Data File/B Version VII Release 0 (ENDF/B-VII.0), use the same fine-group and broad-group energy structures as the VITAMIN-B6 and BUGLE-96 libraries. The processing methodology used to generate both libraries is based on the methods used to develop VITAMIN-B6 and BUGLE-96 and is consistent with ANSI/ANS 6.1.2. The ENDF data were first processed into the fine-group pseudo-problem-independent VITAMIN-B7 library and then collapsed into the broad-group BUGLE-B7 library. The VITAMIN-B7 library containsmore » data for 391 nuclides. This represents a significant increase compared to the VITAMIN-B6 library, which contained data for 120 nuclides. The BUGLE-B7 library contains data for the same nuclides as BUGLE-96, and maintains the same numeric IDs for those nuclides. The broad-group data includes nuclides which are infinitely dilute and group collapsed using a concrete weighting spectrum, as well as nuclides which are self-shielded and group collapsed using weighting spectra representative of important regions of LWRs. The verification and validation of the new libraries includes a set of critical benchmark experiments, a set of regression tests that are used to evaluate multigroup crosssection libraries in the SCALE code system, and three pressure vessel dosimetry benchmarks. Results of these tests confirm that the new libraries are appropriate for use in LWR shielding analyses and meet the requirements of Regulatory Guide 1.190.« less

An Investigation of the Educational Needs of Health Sciences Library Manpower: I. Definition of the Manpower Problem and Research Design*

PubMed Central

Kronick, David A.; Rees, Alan M.; Rothenberg, Lesliebeth

1970-01-01

In order to plan adequately for education in health science librarianship and to be able to project future demands and needs we need to know a great deal more about existing manpower in health science libraries. This paper, the first in a series of reports on an investigation to gather this data, discusses the research methodology and the development of an inventory of the institution-program population upon which the survey is based. An analysis in terms of geographic location, type (educational, research, etc.), administrative control, and primary cognate area of these institutions is presented, and their distribution through the various Regional Medical Library areas is noted. Preliminary estimates are made, based on a questionnaire to the libraries, on the size of the library population, their relationship to reporting programs or institutions, exclusive of the hospital population which is being covered in an independent survey. A questionnaire to library personnel is underway which will establish, along with the other questionnaires, a basis for exploring the relationships which exist between institutions or programs, libraries and manpower. PMID:5411708

Community Digital Library Requirements for the Southern California Earthquake Center Community Modeling Environment (SCEC/CME)

NASA Astrophysics Data System (ADS)

Moore, R.; Faerman, M.; Minster, J.; Day, S. M.; Ely, G.

2003-12-01

A community digital library provides support for ingestion, organization, description, preservation, and access of digital entities. The technologies that traditionally provide these capabilities are digital libraries (ingestion, organization, description), persistent archives (preservation) and data grids (access). We present a design for the SCEC community digital library that incorporates aspects of all three systems. Multiple groups have created integrated environments that sustain large-scale scientific data collections. By examining these projects, the following stages of implementation can be identified: \\begin{itemize} Definition of semantic terms to associate with relevant information. This includes definition of uniform content descriptors to describe physical quantities relevant to the scientific discipline, and creation of concept spaces to define how the uniform content descriptors are logically related. Organization of digital entities into logical collections that make it simple to browse and manage related material. Definition of services that are used to access and manipulate material in the collection. Creation of a preservation environment for the long-term management of the collection. Each community is faced with heterogeneity that is introduced when data is distributed across multiple sites, or when multiple sets of collection semantics are used, and or when multiple scientific sub-disciplines are federated. We will present the relevant standards that simplify the implementation of the SCEC community library, the resource requirements for different types of data sets that drive the implementation, and the digital library processes that the SCEC community library will support. The SCEC community library can be viewed as the set of processing steps that are required to build the appropriate SCEC reference data sets (SCEC approved encoding format, SCEC approved descriptive metadata, SCEC approved collection organization, and SCEC managed storage location). Each digital entity that is ingested into the SCEC community library is processed and validated for conformance to SCEC standards. These steps generate provenance, descriptive, administrative, structural, and behavioral metadata. Using data grid technology, the descriptive metadata can be registered onto a logical name space that is controlled and managed by the SCEC digital library. A version of the SCEC community digital library is being implemented in the Storage Resource Broker. The SRB system provides almost all the features enumerated above. The peer-to-peer federation of metadata catalogs is planned for release in September, 2003. The SRB system is in production use in multiple projects, from high-energy physics, to astronomy, to earth systems science, to bio-informatics. The SCEC community library will be based on the definition of standard metadata attributes, the creation of logical collections within the SRB, the creation of access services, and the demonstration of a preservation environment. The use of the SRB for the SCEC digital library will sustain the expected collection size and collection capabilities.

28 CFR 0.75 - Policy functions.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., automated information services, publication services, library services and any other Department-wide central...) Provide computer and digital telecommunications services on an equitable resource-sharing basis to all...

28 CFR 0.75 - Policy functions.

Code of Federal Regulations, 2011 CFR

2011-07-01

..., automated information services, publication services, library services and any other Department-wide central...) Provide computer and digital telecommunications services on an equitable resource-sharing basis to all...

Basis sets for the calculation of core-electron binding energies

NASA Astrophysics Data System (ADS)

Hanson-Heine, Magnus W. D.; George, Michael W.; Besley, Nicholas A.

2018-05-01

Core-electron binding energies (CEBEs) computed within a Δ self-consistent field approach require large basis sets to achieve convergence with respect to the basis set limit. It is shown that supplementing a basis set with basis functions from the corresponding basis set for the element with the next highest nuclear charge (Z + 1) provides basis sets that give CEBEs close to the basis set limit. This simple procedure provides relatively small basis sets that are well suited for calculations where the description of a core-ionised state is important, such as time-dependent density functional theory calculations of X-ray emission spectroscopy.

Where to Publish and Find Ontologies? A Survey of Ontology Libraries

PubMed Central

d'Aquin, Mathieu; Noy, Natalya F.

2011-01-01

One of the key promises of the Semantic Web is its potential to enable and facilitate data interoperability. The ability of data providers and application developers to share and reuse ontologies is a critical component of this data interoperability: if different applications and data sources use the same set of well defined terms for describing their domain and data, it will be much easier for them to “talk” to one another. Ontology libraries are the systems that collect ontologies from different sources and facilitate the tasks of finding, exploring, and using these ontologies. Thus ontology libraries can serve as a link in enabling diverse users and applications to discover, evaluate, use, and publish ontologies. In this paper, we provide a survey of the growing—and surprisingly diverse—landscape of ontology libraries. We highlight how the varying scope and intended use of the libraries a ects their features, content, and potential exploitation in applications. From reviewing eleven ontology libraries, we identify a core set of questions that ontology practitioners and users should consider in choosing an ontology library for finding ontologies or publishing their own. We also discuss the research challenges that emerge from this survey, for the developers of ontology libraries to address. PMID:22408576

Trends in hospital librarianship and hospital library services: 1989 to 2006.

PubMed

Thibodeau, Patricia L; Funk, Carla J

2009-10-01

The research studied the status of hospital librarians and library services to better inform the Medical Library Association's advocacy activities. The Vital Pathways Survey Subcommittee of the Task Force on Vital Pathways for Hospital Librarians distributed a web-based survey to hospital librarians and academic health sciences library directors. The survey results were compared to data collected in a 1989 survey of hospital libraries by the American Hospital Association in order to identify any trends in hospital libraries, roles of librarians, and library services. A web-based hospital library report form based on the survey questions was also developed to more quickly identify changes in the status of hospital libraries on an ongoing basis. The greatest change in library services between 1989 and 2005/06 was in the area of access to information, with 40% more of the respondents providing access to commercial online services, 100% more providing access to Internet resources, and 28% more providing training in database searching and use of information resources. Twenty-nine percent (n = 587) of the 2005/06 respondents reported a decrease in staff over the last 5 years. Survey data support reported trends of consolidation of hospitals and hospital libraries and additions of new services. These services have likely required librarians to acquire new skills. It is hoped that future surveys will be undertaken to continue to study these trends.

Trends in hospital librarianship and hospital library services: 1989 to 2006

PubMed Central

Thibodeau, Patricia L.; Funk, Carla J.

2009-01-01

Objective: The research studied the status of hospital librarians and library services to better inform the Medical Library Association's advocacy activities. Methods: The Vital Pathways Survey Subcommittee of the Task Force on Vital Pathways for Hospital Librarians distributed a web-based survey to hospital librarians and academic health sciences library directors. The survey results were compared to data collected in a 1989 survey of hospital libraries by the American Hospital Association in order to identify any trends in hospital libraries, roles of librarians, and library services. A web-based hospital library report form based on the survey questions was also developed to more quickly identify changes in the status of hospital libraries on an ongoing basis. Results: The greatest change in library services between 1989 and 2005/06 was in the area of access to information, with 40% more of the respondents providing access to commercial online services, 100% more providing access to Internet resources, and 28% more providing training in database searching and use of information resources. Twenty-nine percent (n = 587) of the 2005/06 respondents reported a decrease in staff over the last 5 years. Conclusions: Survey data support reported trends of consolidation of hospitals and hospital libraries and additions of new services. These services have likely required librarians to acquire new skills. It is hoped that future surveys will be undertaken to continue to study these trends. PMID:19851491

PROPERTY APPRAISAL PROVIDES CONTROL, INSURANCE BASIS, AND VALUE ESTIMATE.

ERIC Educational Resources Information Center

THOMSON, JACK

A COMPLETE PROPERTY APPRAISAL SERVES AS A BASIS FOR CONTROL, INSURANCE AND VALUE ESTIMATE. A PROFESSIONAL APPRAISAL FIRM SHOULD PERFORM THIS FUNCTION BECAUSE (1) IT IS FAMILIAR WITH PROPER METHODS, (2) IT CAN PREPARE THE REPORT WITH MINIMUM CONFUSION AND INTERRRUPTION OF THE COLLEGE OPERATION, (3) USE OF ITS PRICING LIBRARY REDUCES TIME NEEDED AND…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Papajak, Ewa; Truhlar, Donald G.

We present sets of convergent, partially augmented basis set levels corresponding to subsets of the augmented “aug-cc-pV(n+d)Z” basis sets of Dunning and co-workers. We show that for many molecular properties a basis set fully augmented with diffuse functions is computationally expensive and almost always unnecessary. On the other hand, unaugmented cc-pV(n+d)Z basis sets are insufficient for many properties that require diffuse functions. Therefore, we propose using intermediate basis sets. We developed an efficient strategy for partial augmentation, and in this article, we test it and validate it. Sequentially deleting diffuse basis functions from the “aug” basis sets yields the “jul”,more » “jun”, “may”, “apr”, etc. basis sets. Tests of these basis sets for Møller-Plesset second-order perturbation theory (MP2) show the advantages of using these partially augmented basis sets and allow us to recommend which basis sets offer the best accuracy for a given number of basis functions for calculations on large systems. Similar truncations in the diffuse space can be performed for the aug-cc-pVxZ, aug-cc-pCVxZ, etc. basis sets.« less

45 CFR 1706.102 - Application.

Code of Federal Regulations, 2012 CFR

2012-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.102 Application. This part...

45 CFR 1706.102 - Application.

Code of Federal Regulations, 2013 CFR

2013-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.102 Application. This part...

45 CFR 1706.140 - Employment.

Code of Federal Regulations, 2013 CFR

2013-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.140 Employment. No qualified...

45 CFR 1706.140 - Employment.

Code of Federal Regulations, 2014 CFR

2014-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.140 Employment. No qualified...

45 CFR 1706.140 - Employment.

Code of Federal Regulations, 2011 CFR

2011-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.140 Employment. No qualified...

45 CFR 1706.102 - Application.

Code of Federal Regulations, 2014 CFR

2014-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.102 Application. This part...

45 CFR 1706.102 - Application.

Code of Federal Regulations, 2011 CFR

2011-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.102 Application. This part...

45 CFR 1706.140 - Employment.

Code of Federal Regulations, 2012 CFR

2012-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.140 Employment. No qualified...

45 CFR 1706.160 - Communications.

Code of Federal Regulations, 2010 CFR

2010-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.160 Communications. (a) The...

45 CFR 1706.102 - Application.

Code of Federal Regulations, 2010 CFR

2010-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.102 Application. This part...

45 CFR 1706.140 - Employment.

Code of Federal Regulations, 2010 CFR

2010-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.140 Employment. No qualified...

Evaluating Machine Learning Classifiers for Hybrid Network Intrusion Detection Systems

DTIC Science & Technology

2015-03-26

7 VRT Vulnerability Research Team...and the Talos (formerly the Vulnerability Research Team ( VRT )) [7] 7 ruleset libraries are the two leading rulesets in use. Both libraries offer paid...rule sets to load for the signature-based IDS. Snort is selected as the IDS engine using the “ VRT and ET No/GPL” rule set. The total rule count in the

Relationship of Technology and Characteristics of Library Functional Units.

ERIC Educational Resources Information Center

Lynch, Beverly P.; Verdin, Jo Ann

The project summarized in this report collected data from 3 of the 25 largest Association of Research Library (ARL) member libraries in order to: (1) examine the durability of the measure of technology set forth in "An Empirical Assessment of Perrow's Technology Construct" (Administrative Science Quarterly, 1974, pp. 338-356); (2) study…

Subject Liaisons in Academic Libraries: An Open Access Data Set from 2015

ERIC Educational Resources Information Center

Nero, Neil; Langley, Anne

2017-01-01

The work of subject liaison librarians in academic libraries has morphed to include a variety of roles that reach beyond the traditional. This study captures responses of 1,808 participants from land-grant, Oberlin Group, and Association of Research Libraries (ARL) institutions to a questionnaire about subject liaison librarians. The questionnaire…

Disaster Preparedness Manual.

ERIC Educational Resources Information Center

Michael, Douglas O.

Prepared for use by the staff of a community college library, this manual describes the natural, building, and human hazards which can result in disaster in a library and outlines a set of disaster prevention measures and salvage procedures. A list of salvage priorities, floor plans for all three levels of Bourke Memorial Library, and staff duties…

Two Ways to Set Up Wireless Hotspot: Comparing Apples and Oranges

ERIC Educational Resources Information Center

Mutch, Andrew; Ventura, Karen

2006-01-01

Every place has it--coffee shops, bookstores, universities ... and now libraries are offering wireless Internet access too. At the Waterford Township Public Library (Waterford, Michigan), Andrew Mutch created a wide-open wireless network using Public IP open source software. About 20 miles away, at the Novi Public Library (Novi, Michigan), Karen…

Free and Beautiful: Lucia Chen--New York Public Library

ERIC Educational Resources Information Center

Library Journal, 2004

2004-01-01

This article details the work of Lucia Chen of the New York Public Library. Lucia Chen combined her two passions--organization and beautification--in her recent project, creating an online version of the New York Public Library's (NYPL) legendary picture collection. Artists ranging from set designers to filmmakers have long used the collection,…

Measures for Electronic Resources (E-Metrics). Complete Set.

ERIC Educational Resources Information Center

Association of Research Libraries, Washington, DC.

The Association of Research Libraries (ARL) E-Metrics study was designed as an 18-month project in three phases: an inventory of what libraries were already doing about data collection for electronic resources and an identification of any libraries that could provide best practice; identifying and testing data elements that could be collected and…

36 CFR 703.15 - Purpose and scope of this subpart.

Code of Federal Regulations, 2010 CFR

2010-07-01

... Proceedings Where the Library Is Not a Party § 703.15 Purpose and scope of this subpart. This subpart sets forth the policy and procedures of the Library of Congress regarding, first, the testimony, as witnesses... subpart. 703.15 Section 703.15 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR...

36 CFR 703.15 - Purpose and scope of this subpart.

Code of Federal Regulations, 2014 CFR

2014-07-01

... subpart. 703.15 Section 703.15 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR... Proceedings Where the Library Is Not a Party § 703.15 Purpose and scope of this subpart. This subpart sets forth the policy and procedures of the Library of Congress regarding, first, the testimony, as witnesses...

36 CFR 703.15 - Purpose and scope of this subpart.

Code of Federal Regulations, 2012 CFR

2012-07-01

... subpart. 703.15 Section 703.15 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR... Proceedings Where the Library Is Not a Party § 703.15 Purpose and scope of this subpart. This subpart sets forth the policy and procedures of the Library of Congress regarding, first, the testimony, as witnesses...

36 CFR 703.15 - Purpose and scope of this subpart.

Code of Federal Regulations, 2011 CFR

2011-07-01

... subpart. 703.15 Section 703.15 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR... Proceedings Where the Library Is Not a Party § 703.15 Purpose and scope of this subpart. This subpart sets forth the policy and procedures of the Library of Congress regarding, first, the testimony, as witnesses...

From Commons to Classroom: The Evolution of Learning Spaces in Academic Libraries

ERIC Educational Resources Information Center

Karasic, Victoria

2016-01-01

Over the past two decades, academic library spaces have evolved to meet the changing teaching and learning needs of diverse campus communities. The Information Commons combines the physical and virtual in an informal library space, whereas the recent Active Learning Classroom creates a more formal setting for collaboration. As scholarship has…

Libraries without Resources: Towards Personal Collections.

ERIC Educational Resources Information Center

Savenije, Bas; Grygierczyk, Natalia

The main function of the library of the future is to provide access to electronic sources stored elsewhere. In order to comply with the users' needs, therefore, flexible license scenarios are necessary. Another future function of the library will be to set up and maintain a personal alerting system and to assist users in organizing their own…

School Librarian as Inquisitor of Practice: Reimagine, Reflect, and React with the New Standards

ERIC Educational Resources Information Center

Burns, Elizabeth

2018-01-01

The modern school library is a complex social setting "grounded in standards and best practice" (AASL 2018). The new "National School Library Standards" have refreshed the student learning standards and aligned new Shared Foundations to the school library. Additionally, the competencies for learners are now complemented by…

Creating Electronic Tutorials: On Your Mark, Get Set, Go!

ERIC Educational Resources Information Center

Plumb, Tawnya K.

2010-01-01

As library patrons move online, librarians must move instructional content online to join them. One means of educating library users is to meet them on their computers with electronic tutorials. Electronic tutorials may be used for various instructional tasks such as teaching users about the basic elements of a library catalog, pointing out the…

[Problems Inherent in Attempting Standardization of Libraries.

ERIC Educational Resources Information Center

Port, Idelle

In setting standards for a large and geographically dispersed library system, one must reconcile the many varying practices that affect what is being measured or discussed. The California State University and Colleges (CSUC) consists of 19 very distinct campuses. The problems and solutions of one type of CSUC library are not likely to be those of…

Estimating the CCSD basis-set limit energy from small basis sets: basis-set extrapolations vs additivity schemes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Spackman, Peter R.; Karton, Amir, E-mail: amir.karton@uwa.edu.au

Coupled cluster calculations with all single and double excitations (CCSD) converge exceedingly slowly with the size of the one-particle basis set. We assess the performance of a number of approaches for obtaining CCSD correlation energies close to the complete basis-set limit in conjunction with relatively small DZ and TZ basis sets. These include global and system-dependent extrapolations based on the A + B/L{sup α} two-point extrapolation formula, and the well-known additivity approach that uses an MP2-based basis-set-correction term. We show that the basis set convergence rate can change dramatically between different systems(e.g.it is slower for molecules with polar bonds and/ormore » second-row elements). The system-dependent basis-set extrapolation scheme, in which unique basis-set extrapolation exponents for each system are obtained from lower-cost MP2 calculations, significantly accelerates the basis-set convergence relative to the global extrapolations. Nevertheless, we find that the simple MP2-based basis-set additivity scheme outperforms the extrapolation approaches. For example, the following root-mean-squared deviations are obtained for the 140 basis-set limit CCSD atomization energies in the W4-11 database: 9.1 (global extrapolation), 3.7 (system-dependent extrapolation), and 2.4 (additivity scheme) kJ mol{sup –1}. The CCSD energy in these approximations is obtained from basis sets of up to TZ quality and the latter two approaches require additional MP2 calculations with basis sets of up to QZ quality. We also assess the performance of the basis-set extrapolations and additivity schemes for a set of 20 basis-set limit CCSD atomization energies of larger molecules including amino acids, DNA/RNA bases, aromatic compounds, and platonic hydrocarbon cages. We obtain the following RMSDs for the above methods: 10.2 (global extrapolation), 5.7 (system-dependent extrapolation), and 2.9 (additivity scheme) kJ mol{sup –1}.« less

Estimating the CCSD basis-set limit energy from small basis sets: basis-set extrapolations vs additivity schemes

NASA Astrophysics Data System (ADS)

Spackman, Peter R.; Karton, Amir

2015-05-01

Coupled cluster calculations with all single and double excitations (CCSD) converge exceedingly slowly with the size of the one-particle basis set. We assess the performance of a number of approaches for obtaining CCSD correlation energies close to the complete basis-set limit in conjunction with relatively small DZ and TZ basis sets. These include global and system-dependent extrapolations based on the A + B/Lα two-point extrapolation formula, and the well-known additivity approach that uses an MP2-based basis-set-correction term. We show that the basis set convergence rate can change dramatically between different systems(e.g.it is slower for molecules with polar bonds and/or second-row elements). The system-dependent basis-set extrapolation scheme, in which unique basis-set extrapolation exponents for each system are obtained from lower-cost MP2 calculations, significantly accelerates the basis-set convergence relative to the global extrapolations. Nevertheless, we find that the simple MP2-based basis-set additivity scheme outperforms the extrapolation approaches. For example, the following root-mean-squared deviations are obtained for the 140 basis-set limit CCSD atomization energies in the W4-11 database: 9.1 (global extrapolation), 3.7 (system-dependent extrapolation), and 2.4 (additivity scheme) kJ mol-1. The CCSD energy in these approximations is obtained from basis sets of up to TZ quality and the latter two approaches require additional MP2 calculations with basis sets of up to QZ quality. We also assess the performance of the basis-set extrapolations and additivity schemes for a set of 20 basis-set limit CCSD atomization energies of larger molecules including amino acids, DNA/RNA bases, aromatic compounds, and platonic hydrocarbon cages. We obtain the following RMSDs for the above methods: 10.2 (global extrapolation), 5.7 (system-dependent extrapolation), and 2.9 (additivity scheme) kJ mol-1.

Scaffold architecture and pharmacophoric properties of natural products and trade drugs: application in the design of natural product-based combinatorial libraries.

PubMed

Lee, M L; Schneider, G

2001-01-01

Natural products were analyzed to determine whether they contain appealing novel scaffold architectures for potential use in combinatorial chemistry. Ring systems were extracted and clustered on the basis of structural similarity. Several such potential scaffolds for combinatorial chemistry were identified that are not present in current trade drugs. For one of these scaffolds a virtual combinatorial library was generated. Pharmacophoric properties of natural products, trade drugs, and the virtual combinatorial library were assessed using a self-organizing map. Obviously, current trade drugs and natural products have several topological pharmacophore patterns in common. These features can be systematically explored with selected combinatorial libraries based on a combination of natural product-derived and synthetic molecular building blocks.

An EMTP system level model of the PMAD DC test bed

NASA Technical Reports Server (NTRS)

Dravid, Narayan V.; Kacpura, Thomas J.; Tam, Kwa-Sur

1991-01-01

A power management and distribution direct current (PMAD DC) test bed was set up at the NASA Lewis Research Center to investigate Space Station Freedom Electric Power Systems issues. Efficiency of test bed operation significantly improves with a computer simulation model of the test bed as an adjunct tool of investigation. Such a model is developed using the Electromagnetic Transients Program (EMTP) and is available to the test bed developers and experimenters. The computer model is assembled on a modular basis. Device models of different types can be incorporated into the system model with only a few lines of code. A library of the various model types is created for this purpose. Simulation results and corresponding test bed results are presented to demonstrate model validity.

New DMFT capabilities in CASTEP

NASA Astrophysics Data System (ADS)

Plekhanov, Evgeny; Sacksteder, Vincent; Hasnip, Phil; Probert, Matt; Clark, Stewart; Weber, Cedric; Refson, Keith

We present the first implementation of Dynamical Mean-Field Theory in UK's major ab-initio code CASTEP. This implementation: i) is modular; ii) allows great flexibility in choosing local basis set for downfolding/upfolding of self-energy; iii) permits wide choice of impurity solvers (including external solver libraries); and iv) gives the user a possibility to use several self-consistency schemes and calculate total energy and forces. We explain in details the theoretical framework used. We benchmark our implementation on several strongly-correlated insulating systems with d- and f-shells: γ-Ce and Ce2O3 by using Hubbard I and CTHYB-QMC solvers. Our results appear to be in excellent agreement with the reference data published previously in the literature. EPSRC-funded project ''Strong Correlation meets Materials Modelling: DMFT and GW in CASTEP''.

Development of an Integrated, Computer-Based Bibliographical Data System for a Large University Library. Annual Report to the National Science Foundation from the University of Chicago Library, 1966/67.

ERIC Educational Resources Information Center

Fussler, Herman; Payne, Charles T.

Part I is a discussion of the following project tasks: A) development of an on-line, real-time bibliographic data processing system; B) implementation in library operations; C) character sets; D) Project MARC; E) circulation; and F) processing operation studies. Part II is a brief discussion of efforts to work out cooperative library systems…

Developing a Strategic Plan for Transitioning to Healthcare Knowledge Services Centers (HKSCs)

PubMed Central

Goldstein, H. Mark; Coletti, Margaret H.

2012-01-01

Facing a negative trend in the form of downsizing, layoffs, and closures, a small committee of hospital librarians in New England was formed in 2004 to provide library advocacy. Between 2008 and 2010, 23 hospital libraries closed in New England. In 2010, the committee shifted its focus from advocacy to a platform for change. This resulted in the creation of the Healthcare Knowledge Services Center (HKSC) Template. The Template is the basis for a 3-phased, 5-year strategic plan to establish several regional pilots, transitioning traditional hospital libraries to healthcare knowledge services centers. This article focuses on Phase One of the strategic plan, Development. PMID:23125551

Parallel computation and the Basis system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, G.R.

1992-12-16

A software package has been written that can facilitate efforts to develop powerful, flexible, and easy-to-use programs that can run in single-processor, massively parallel, and distributed computing environments. Particular attention has been given to the difficulties posed by a program consisting of many science packages that represent subsystems of a complicated, coupled system. Methods have been found to maintain independence of the packages by hiding data structures without increasing the communication costs in a parallel computing environment. Concepts developed in this work are demonstrated by a prototype program that uses library routines from two existing software systems, Basis and Parallelmore » Virtual Machine (PVM). Most of the details of these libraries have been encapsulated in routines and macros that could be rewritten for alternative libraries that possess certain minimum capabilities. The prototype software uses a flexible master-and-slaves paradigm for parallel computation and supports domain decomposition with message passing for partitioning work among slaves. Facilities are provided for accessing variables that are distributed among the memories of slaves assigned to subdomains. The software is named PROTOPAR.« less

Parallel computation and the basis system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, G.R.

1993-05-01

A software package has been written that can facilitate efforts to develop powerful, flexible, and easy-to use programs that can run in single-processor, massively parallel, and distributed computing environments. Particular attention has been given to the difficulties posed by a program consisting of many science packages that represent subsystems of a complicated, coupled system. Methods have been found to maintain independence of the packages by hiding data structures without increasing the communications costs in a parallel computing environment. Concepts developed in this work are demonstrated by a prototype program that uses library routines from two existing software systems, Basis andmore » Parallel Virtual Machine (PVM). Most of the details of these libraries have been encapsulated in routines and macros that could be rewritten for alternative libraries that possess certain minimum capabilities. The prototype software uses a flexible master-and-slaves paradigm for parallel computation and supports domain decomposition with message passing for partitioning work among slaves. Facilities are provided for accessing variables that are distributed among the memories of slaves assigned to subdomains. The software is named PROTOPAR.« less

45 CFR 1706.110 - Self-evaluation.

Code of Federal Regulations, 2013 CFR

2013-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.110 Self-evaluation. (a) The...

45 CFR 1706.110 - Self-evaluation.

Code of Federal Regulations, 2012 CFR

2012-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.110 Self-evaluation. (a) The...

45 CFR 1706.110 - Self-evaluation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.110 Self-evaluation. (a) The...

45 CFR 1706.110 - Self-evaluation.

Code of Federal Regulations, 2014 CFR

2014-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.110 Self-evaluation. (a) The...

45 CFR 1706.110 - Self-evaluation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE § 1706.110 Self-evaluation. (a) The...

Building a bioinformatics community of practice through library education programs.

PubMed

Moore, Margaret E; Vaughan, K T L; Hayes, Barrie E

2004-01-01

This paper addresses the following questions:What makes the community of practice concept an intriguing framework for developing library services for bioinformatics? What is the campus context and setting? What has been the Health Sciences Library's role in bioinformatics at the University of North Carolina (UNC) Chapel Hill? What are the Health Sciences Library's goals? What services are currently offered? How will these services be evaluated and developed? How can libraries demonstrate their value? Providing library services for an emerging community such as bioinformatics and computational biology presents special challenges for libraries including understanding needs, defining and communicating the library's role, building relationships within the community, preparing staff, and securing funding. Like many academic health sciences libraries, the University of North Carolina (UNC) at Chapel Hill Health Sciences Library is addressing these challenges in the context of its overall mission and goals.

Real-Time Ada Problem Study

DTIC Science & Technology

1989-03-24

Specified Test Verification Matri_ .. 39 3.2.6.5 Test Generation Assistance. .............. . .. ......... 40 3.2.7 Maintenance...lack of intimate knowledge of how the runtime links to the compiler generated code. Furthermore, the runime must meet a rigorous set of tests to insure...projects, and is not provided. Along with the library, a set of tests should be provided to verify the accuracy of the library after changes have been

Improving Library Service Quality to Graduate Students: LibQual+[TM] Survey Results in a Practical Setting

ERIC Educational Resources Information Center

Jankowska, Maria Anna; Hertel, Karen; Young, Nancy J.

2006-01-01

The LibQUAL+[TM] survey was conducted to determine user satisfaction and expectations concerning library service quality. The results of the "22 items and a box" constituted a rich source of information for the University of Idaho (UI) Library's strategic planning process. Focusing on graduate students, this study used three…

The Internet Initiative: Libraries Providing Internet Services and How They Plan, Pay, and Manage.

ERIC Educational Resources Information Center

Valauskas, Edward J., Ed.; John, Nancy R., Ed.

This book examines real-life projects involving Internet access, use, and financing in libraries. It focuses on how becoming an Internet provider has improved many libraries' public visibility, level of service, and communication with other educational or community institutions. Chapters include: (1) "Setting Up an Internet Users Group in the…

Library Staff Development Workshops in an Urban University. A Project Report.

ERIC Educational Resources Information Center

Harris, Jamie L.; Meeker, Robert B.

This set of materials reports the needs assessment and implementation of a library staff development project funded by a Chicago State University grant. Because of the limited opportunity provided for all library personnel to improve their job skills, a proposal for a staff development program was submitted to the university granting office. A…

Motivational Properties of Support Staff Tasks in the Face of Automation.

ERIC Educational Resources Information Center

Garten, Edward D.

This paper maintains that staff needs which are both implicit and explicit within the automation-laden technical services work in a library setting most often do not receive adequate attention from the library's supervisory staff. It argues that analysis of problem areas within a given unit in the library can better promote positive strategies for…

Impact of After-School Nutrition Workshops in a Public Library Setting

ERIC Educational Resources Information Center

Freedman, Marjorie R.; Nickell, Audrey

2010-01-01

Objective: To determine if after-school nutrition workshops conducted in public libraries were related to lasting changes in food choice. Methods: "Snack Smart" workshops, based on Social Cognitive Theory, were conducted in 8 branch libraries (49 ethnically diverse children, ages 9 to 14) to assess changes in consumption of targeted food items by…

A Bookless Library, Part I: Relocating Print Materials to Off-Site Storage

ERIC Educational Resources Information Center

Sewell, Bethany B.

2013-01-01

This article presents an analysis of the feasibility of a bookless library in a research setting. As spaces for collections are being converted for increased study and community spaces, many libraries have been moving low-use collections to off-site storage. Issues regarding the types of storage spaces available are addressed. Concerns and…

Guidelines for Audiovisual and Multimedia Materials in Libraries and Other Institutions. Audiovisual and Multimedia Section

ERIC Educational Resources Information Center

International Federation of Library Associations and Institutions (NJ1), 2004

2004-01-01

This set of guidelines, for audiovisual and multimedia materials in libraries of all kinds and other appropriate institutions, is the product of many years of consultation and collaborative effort. As early as 1972, The UNESCO (United Nations Educational, Scientific and Cultural Organization) Public Library Manifesto had stressed the need for…

Online Opportunist: Mary Ellen Icaza--Montgomery County Public Libraries, Rockville, MD

ERIC Educational Resources Information Center

Library Journal, 2004

2004-01-01

When Mary Ellen Icaza became Electronic Services Librarian at Montgomery County Public Libraries, she noticed that the readers' services information on the library web site was invisible, even to librarians. "And if staff can't find it," she says, "customers can't." She set out to help people find that material-and to turn a…

The Friends of Northside ISD Libraries Sets Sail

ERIC Educational Resources Information Center

Hultgren, Joyce

2009-01-01

The Director of Library and Textbook services for the Northside Independent School District (NISD) Jana Knezek, had long wanted to create a Friends group and she realized how beneficial it would be to have an organization in place that could serve as an advocate for school library issues. Jana temporarily put aside that desire and participated in…

78 FR 42872 - Communication with the U.S. Copyright Office: Revised Addresses

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-18

... LIBRARY OF CONGRESS U.S. Copyright Office 37 CFR Parts 201 and 202 [Docket No. 2013-7] Communication with the U.S. Copyright Office: Revised Addresses AGENCY: U.S. Copyright Office, Library of..., LIBRARY OF CONGRESS 0 1. The heading of chapter II is revised to read as set forth above. PART 201...

Makerspaces in the Library: Science in a Student's Hands

ERIC Educational Resources Information Center

Julian, Kristi D.; Parrott, Deborah J.

2017-01-01

Makerspaces supply a venue for students to construct a variety of real-world products at the collegiate level using science and technology standards. The maker movement is sweeping the science learning community by storm in the library setting with remarkable success. The maker movement provides an opportunity to transform the library into a…

Building a Better Fragment Library for De Novo Protein Structure Prediction

PubMed Central

de Oliveira, Saulo H. P.; Shi, Jiye; Deane, Charlotte M.

2015-01-01

Fragment-based approaches are the current standard for de novo protein structure prediction. These approaches rely on accurate and reliable fragment libraries to generate good structural models. In this work, we describe a novel method for structure fragment library generation and its application in fragment-based de novo protein structure prediction. The importance of correct testing procedures in assessing the quality of fragment libraries is demonstrated. In particular, the exclusion of homologs to the target from the libraries to correctly simulate a de novo protein structure prediction scenario, something which surprisingly is not always done. We demonstrate that fragments presenting different predominant predicted secondary structures should be treated differently during the fragment library generation step and that exhaustive and random search strategies should both be used. This information was used to develop a novel method, Flib. On a validation set of 41 structurally diverse proteins, Flib libraries presents both a higher precision and coverage than two of the state-of-the-art methods, NNMake and HHFrag. Flib also achieves better precision and coverage on the set of 275 protein domains used in the two previous experiments of the the Critical Assessment of Structure Prediction (CASP9 and CASP10). We compared Flib libraries against NNMake libraries in a structure prediction context. Of the 13 cases in which a correct answer was generated, Flib models were more accurate than NNMake models for 10. “Flib is available for download at: http://www.stats.ox.ac.uk/research/proteins/resources”. PMID:25901595

International Federation of Library Associations Annual Conference. Papers of the Special Libraries Division: Geographical and Map, Science and Technology and Social Science Libraries Sections (47th, Leipzig, East Germany, August 17-22, 1981).

ERIC Educational Resources Information Center

Sprudzs, Adolf; And Others

This set of eight papers includes papers presented by participants from the United States, France, East Germany, the United Kingdom, West Germany, and the USSR: "Problems with Sources of Information in International Law and Relations: The Case of the World-Wide Treaty Jungle," by Adolf Sprudzs; "French Map Libraries and National and…

45 CFR 1706.131-1706.139 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.131-1706.139...

45 CFR 1706.161-1706.169 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.161-1706.169...

45 CFR 1706.131-1706.139 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.131-1706.139...

45 CFR 1706.141-1706.148 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.141-1706.148...

45 CFR 1706.171-1706.999 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.171-1706.999...

45 CFR 1706.104-1706.109 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.104-1706.109...

45 CFR 1706.104-1706.109 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.104-1706.109...

45 CFR 1706.152-1706.159 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.152-1706.159...

45 CFR 1706.112-1706.129 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.112-1706.129...

45 CFR 1706.131-1706.139 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.131-1706.139...

45 CFR 1706.161-1706.169 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.161-1706.169...

45 CFR 1706.171-1706.999 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.171-1706.999...

45 CFR 1706.152-1706.159 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.152-1706.159...

45 CFR 1706.161-1706.169 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.161-1706.169...

45 CFR 1706.131-1706.139 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.131-1706.139...

45 CFR 1706.141-1706.148 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.141-1706.148...

45 CFR 1706.152-1706.159 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.152-1706.159...

45 CFR 1706.112-1706.129 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.112-1706.129...

45 CFR 1706.161-1706.169 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.161-1706.169...

45 CFR 1706.112-1706.129 - [Reserved

Code of Federal Regulations, 2012 CFR

2012-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.112-1706.129...

45 CFR 1706.152-1706.159 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.152-1706.159...

45 CFR 1706.171-1706.999 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.171-1706.999...

45 CFR 1706.171-1706.999 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.171-1706.999...

45 CFR 1706.104-1706.109 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.104-1706.109...

45 CFR 1706.141-1706.148 - [Reserved

Code of Federal Regulations, 2014 CFR

2014-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.141-1706.148...

45 CFR 1706.104-1706.109 - [Reserved

Code of Federal Regulations, 2013 CFR

2013-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.104-1706.109...

45 CFR 1706.141-1706.148 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.141-1706.148...

45 CFR 1706.112-1706.129 - [Reserved

Code of Federal Regulations, 2011 CFR

2011-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.112-1706.129...

45 CFR 1706.112-1706.129 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.112-1706.129...

45 CFR 1706.171-1706.999 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.171-1706.999...

45 CFR 1706.152-1706.159 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.152-1706.159...

45 CFR 1706.141-1706.148 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.141-1706.148...

45 CFR 1706.161-1706.169 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.161-1706.169...

45 CFR 1706.104-1706.109 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.104-1706.109...

45 CFR 1706.131-1706.139 - [Reserved

Code of Federal Regulations, 2010 CFR

2010-10-01

... AND INFORMATION SCIENCE ENFORCEMENT OF NONDISCRIMINATION ON THE BASIS OF HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY NATIONAL COMMISSION ON LIBRARIES AND INFORMATION SCIENCE §§ 1706.131-1706.139...

Using Media Centers in Education. The NATUL Project. Teacher Use of Library Media Centers in the Future: A National Needs Assessment by Use of Delphi-Fault Tree Analysis for Instructional Development.

ERIC Educational Resources Information Center

Wood, Rulon Kent

This study was designed to arrive at a possible consensus of expert opinions as related to teacher use of library media centers in American public education, and to analyze the essential teacher skills and knowledge suggested by the experts through this systematic methodology. This provided a national needs assessment to serve as a basis for…

Academic health sciences library Website navigation: an analysis of forty-one Websites and their navigation tools.

PubMed

Brower, Stewart M

2004-10-01

The analysis included forty-one academic health sciences library (HSL) Websites as captured in the first two weeks of January 2001. Home pages and persistent navigational tools (PNTs) were analyzed for layout, technology, and links, and other general site metrics were taken. Websites were selected based on rank in the National Network of Libraries of Medicine, with regional and resource libraries given preference on the basis that these libraries are recognized as leaders in their regions and would be the most reasonable source of standards for best practice. A three-page evaluation tool was developed based on previous similar studies. All forty-one sites were evaluated in four specific areas: library general information, Website aids and tools, library services, and electronic resources. Metrics taken for electronic resources included orientation of bibliographic databases alphabetically by title or by subject area and with links to specifically named databases. Based on the results, a formula for determining obligatory links was developed, listing items that should appear on all academic HSL Web home pages and PNTs. These obligatory links demonstrate a series of best practices that may be followed in the design and construction of academic HSL Websites.

Information and research needs of acute-care clinical nurses.

PubMed Central

Spath, M; Buttlar, L

1996-01-01

The majority of nurses surveyed used the library on a regular but limited basis to obtain information needed in caring for or making decisions about their patients. A minority indicated that the libraries in their own institutions totally met their information needs. In fact, only 4% depended on the library to stay abreast of new information and developments in the field. Many of the nurses had their own journal subscriptions, which could account in part for the limited use of libraries and the popularity of the professional journal as the key information source. This finding correlates with the research of Binger and Huntsman, who found that 95% of staff development educators relied on professional journal literature to keep up with current information in the field, and only 45% regularly monitored indexing-and-abstracting services. The present study also revealed that nurses seek information from colleagues more than from any other source, supporting the findings of Corcoran-Perry and Graves. Further research is necessary to clarify why nurses use libraries on a limited basis. It appears, as Bunyan and Lutz contend, that a more aggressive approach to marketing the library to nurses is needed. Further research should include an assessment of how the library can meet the information needs of nurses for both research and patient care. Options to be considered include offering library orientation sessions for new staff nurses, providing current-awareness services by circulating photocopied table-of-contents pages, sending out reviews of new monographs, inviting nurses to submit search requests on a topic, scheduling seminars and workshops that teach CD-ROM and online search strategies, and providing information about electronic databases covering topics related to nursing. Information on databases may be particularly important in light of the present study's finding that databases available in CD-ROM format are consulted very little. Nursing education programs should be expanded to include curricula bibliographic sessions where the librarian, in cooperation with the teaching faculty, visits the classroom to explain all pertinent information sources or invites the class to the library for hands-on demonstration and practice. Nurses who gain working knowledge of the tools that open the doors to retrieval of research findings and who have information about new innovations in medicine and medical technology have superior chances for success in their chosen profession. PMID:8938341

Information and research needs of acute-care clinical nurses.

PubMed

Spath, M; Buttlar, L

1996-01-01

The majority of nurses surveyed used the library on a regular but limited basis to obtain information needed in caring for or making decisions about their patients. A minority indicated that the libraries in their own institutions totally met their information needs. In fact, only 4% depended on the library to stay abreast of new information and developments in the field. Many of the nurses had their own journal subscriptions, which could account in part for the limited use of libraries and the popularity of the professional journal as the key information source. This finding correlates with the research of Binger and Huntsman, who found that 95% of staff development educators relied on professional journal literature to keep up with current information in the field, and only 45% regularly monitored indexing-and-abstracting services. The present study also revealed that nurses seek information from colleagues more than from any other source, supporting the findings of Corcoran-Perry and Graves. Further research is necessary to clarify why nurses use libraries on a limited basis. It appears, as Bunyan and Lutz contend, that a more aggressive approach to marketing the library to nurses is needed. Further research should include an assessment of how the library can meet the information needs of nurses for both research and patient care. Options to be considered include offering library orientation sessions for new staff nurses, providing current-awareness services by circulating photocopied table-of-contents pages, sending out reviews of new monographs, inviting nurses to submit search requests on a topic, scheduling seminars and workshops that teach CD-ROM and online search strategies, and providing information about electronic databases covering topics related to nursing. Information on databases may be particularly important in light of the present study's finding that databases available in CD-ROM format are consulted very little. Nursing education programs should be expanded to include curricula bibliographic sessions where the librarian, in cooperation with the teaching faculty, visits the classroom to explain all pertinent information sources or invites the class to the library for hands-on demonstration and practice. Nurses who gain working knowledge of the tools that open the doors to retrieval of research findings and who have information about new innovations in medicine and medical technology have superior chances for success in their chosen profession.

BEAGLE: an application programming interface and high-performance computing library for statistical phylogenetics.

PubMed

Ayres, Daniel L; Darling, Aaron; Zwickl, Derrick J; Beerli, Peter; Holder, Mark T; Lewis, Paul O; Huelsenbeck, John P; Ronquist, Fredrik; Swofford, David L; Cummings, Michael P; Rambaut, Andrew; Suchard, Marc A

2012-01-01

Phylogenetic inference is fundamental to our understanding of most aspects of the origin and evolution of life, and in recent years, there has been a concentration of interest in statistical approaches such as Bayesian inference and maximum likelihood estimation. Yet, for large data sets and realistic or interesting models of evolution, these approaches remain computationally demanding. High-throughput sequencing can yield data for thousands of taxa, but scaling to such problems using serial computing often necessitates the use of nonstatistical or approximate approaches. The recent emergence of graphics processing units (GPUs) provides an opportunity to leverage their excellent floating-point computational performance to accelerate statistical phylogenetic inference. A specialized library for phylogenetic calculation would allow existing software packages to make more effective use of available computer hardware, including GPUs. Adoption of a common library would also make it easier for other emerging computing architectures, such as field programmable gate arrays, to be used in the future. We present BEAGLE, an application programming interface (API) and library for high-performance statistical phylogenetic inference. The API provides a uniform interface for performing phylogenetic likelihood calculations on a variety of compute hardware platforms. The library includes a set of efficient implementations and can currently exploit hardware including GPUs using NVIDIA CUDA, central processing units (CPUs) with Streaming SIMD Extensions and related processor supplementary instruction sets, and multicore CPUs via OpenMP. To demonstrate the advantages of a common API, we have incorporated the library into several popular phylogenetic software packages. The BEAGLE library is free open source software licensed under the Lesser GPL and available from http://beagle-lib.googlecode.com. An example client program is available as public domain software.

BEAGLE: An Application Programming Interface and High-Performance Computing Library for Statistical Phylogenetics

PubMed Central

Ayres, Daniel L.; Darling, Aaron; Zwickl, Derrick J.; Beerli, Peter; Holder, Mark T.; Lewis, Paul O.; Huelsenbeck, John P.; Ronquist, Fredrik; Swofford, David L.; Cummings, Michael P.; Rambaut, Andrew; Suchard, Marc A.

2012-01-01

Abstract Phylogenetic inference is fundamental to our understanding of most aspects of the origin and evolution of life, and in recent years, there has been a concentration of interest in statistical approaches such as Bayesian inference and maximum likelihood estimation. Yet, for large data sets and realistic or interesting models of evolution, these approaches remain computationally demanding. High-throughput sequencing can yield data for thousands of taxa, but scaling to such problems using serial computing often necessitates the use of nonstatistical or approximate approaches. The recent emergence of graphics processing units (GPUs) provides an opportunity to leverage their excellent floating-point computational performance to accelerate statistical phylogenetic inference. A specialized library for phylogenetic calculation would allow existing software packages to make more effective use of available computer hardware, including GPUs. Adoption of a common library would also make it easier for other emerging computing architectures, such as field programmable gate arrays, to be used in the future. We present BEAGLE, an application programming interface (API) and library for high-performance statistical phylogenetic inference. The API provides a uniform interface for performing phylogenetic likelihood calculations on a variety of compute hardware platforms. The library includes a set of efficient implementations and can currently exploit hardware including GPUs using NVIDIA CUDA, central processing units (CPUs) with Streaming SIMD Extensions and related processor supplementary instruction sets, and multicore CPUs via OpenMP. To demonstrate the advantages of a common API, we have incorporated the library into several popular phylogenetic software packages. The BEAGLE library is free open source software licensed under the Lesser GPL and available from http://beagle-lib.googlecode.com. An example client program is available as public domain software. PMID:21963610

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

PubMed Central

Kuleshov, Maxim V.; Jones, Matthew R.; Rouillard, Andrew D.; Fernandez, Nicolas F.; Duan, Qiaonan; Wang, Zichen; Koplev, Simon; Jenkins, Sherry L.; Jagodnik, Kathleen M.; Lachmann, Alexander; McDermott, Michael G.; Monteiro, Caroline D.; Gundersen, Gregory W.; Ma'ayan, Avi

2016-01-01

Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr. Enrichr currently contains a large collection of diverse gene set libraries available for analysis and download. In total, Enrichr currently contains 180 184 annotated gene sets from 102 gene set libraries. New features have been added to Enrichr including the ability to submit fuzzy sets, upload BED files, improved application programming interface and visualization of the results as clustergrams. Overall, Enrichr is a comprehensive resource for curated gene sets and a search engine that accumulates biological knowledge for further biological discoveries. Enrichr is freely available at: http://amp.pharm.mssm.edu/Enrichr. PMID:27141961

AAHSL Twitter Use From 2007 to 2014: An Exploratory Analysis.

PubMed

Stellrecht, Elizabeth; Hendrix, Dean

2016-01-01

Twitter is a popular social media platform used by organizations for communication and marketing purposes. Many libraries, including members of the Association of Academic Health Sciences Libraries (AAHSL), have Twitter accounts, but how do these libraries use Twitter to communicate with their constituents and are they using it effectively? This study is a large-scale observational study of Twitter use within AAHSL libraries and reflects on the usage patterns present in the context of social media best practices. This study also aims to expand upon best practices for implementing and maintaining a Twitter account in a health sciences library setting.

Nuclear Data Online Services at Peking University

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fan, T.S.; Guo, Z.Y.; Ye, W.G.

2005-05-24

The Institute of Heavy Ion Physics at Peking University has developed a new nuclear data online services software package. Through the web site (http://ndos.nst.pku.edu.cn), it offers online access to main relational nuclear databases: five evaluated neutron libraries (BROND, CENDL, ENDF, JEF, JENDL), the ENSDF library, the EXFOR library, the IAEA photonuclear library and the charged particle data of the FENDL library. This software allows the comparison and graphic representations of the different data sets. The computer programs of this package are based on the Linux implementation of PHP and the MySQL software.

Nuclear Data Online Services at Peking University

NASA Astrophysics Data System (ADS)

Fan, T. S.; Guo, Z. Y.; Ye, W. G.; Liu, W. L.; Liu, T. J.; Liu, C. X.; Chen, J. X.; Tang, G. Y.; Shi, Z. M.; Huang, X. L.; Chen, J. E.

2005-05-01

The Institute of Heavy Ion Physics at Peking University has developed a new nuclear data online services software package. Through the web site (http://ndos.nst.pku.edu.cn), it offers online access to main relational nuclear databases: five evaluated neutron libraries (BROND, CENDL, ENDF, JEF, JENDL), the ENSDF library, the EXFOR library, the IAEA photonuclear library and the charged particle data of the FENDL library. This software allows the comparison and graphic representations of the different data sets. The computer programs of this package are based on the Linux implementation of PHP and the MySQL software.

Big Data - What is it and why it matters.

PubMed

Tattersall, Andy; Grant, Maria J

2016-06-01

Big data, like MOOCs, altmetrics and open access, is a term that has been commonplace in the library community for some time yet, despite its prevalence, many in the library and information sector remain unsure of the relationship between big data and their roles. This editorial explores what big data could mean for the day-to-day practice of health library and information workers, presenting examples of big data in action, considering the ethics of accessing big data sets and the potential for new roles for library and information workers. © 2016 Health Libraries Group.

An Ambystoma mexicanum EST sequencing project: analysis of 17,352 expressed sequence tags from embryonic and regenerating blastema cDNA libraries

PubMed Central

Habermann, Bianca; Bebin, Anne-Gaelle; Herklotz, Stephan; Volkmer, Michael; Eckelt, Kay; Pehlke, Kerstin; Epperlein, Hans Henning; Schackert, Hans Konrad; Wiebe, Glenis; Tanaka, Elly M

2004-01-01

Background The ambystomatid salamander, Ambystoma mexicanum (axolotl), is an important model organism in evolutionary and regeneration research but relatively little sequence information has so far been available. This is a major limitation for molecular studies on caudate development, regeneration and evolution. To address this lack of sequence information we have generated an expressed sequence tag (EST) database for A. mexicanum. Results Two cDNA libraries, one made from stage 18-22 embryos and the other from day-6 regenerating tail blastemas, generated 17,352 sequences. From the sequenced ESTs, 6,377 contigs were assembled that probably represent 25% of the expressed genes in this organism. Sequence comparison revealed significant homology to entries in the NCBI non-redundant database. Further examination of this gene set revealed the presence of genes involved in important cell and developmental processes, including cell proliferation, cell differentiation and cell-cell communication. On the basis of these data, we have performed phylogenetic analysis of key cell-cycle regulators. Interestingly, while cell-cycle proteins such as the cyclin B family display expected evolutionary relationships, the cyclin-dependent kinase inhibitor 1 gene family shows an unusual evolutionary behavior among the amphibians. Conclusions Our analysis reveals the importance of a comprehensive sequence set from a representative of the Caudata and illustrates that the EST sequence database is a rich source of molecular, developmental and regeneration studies. To aid in data mining, the ESTs have been organized into an easily searchable database that is freely available online. PMID:15345051

Isaac Asimov's library of the universe. Index.

NASA Astrophysics Data System (ADS)

Asimov, Isaac

A comprehensive index to the complete set of Isaac Asimov's thirty-two volume Library of the Universe, a series of space science books that introduce young readers to the facts and mysteries of the cosmos.

vis-react-components

DOE Office of Scientific and Technical Information (OSTI.GOV)

Richardson, Gregory D; Goodall, John R; Steed, Chad A

In developing visualizations for different data sets, the end solution often become dependent on the data being visualized. This causes engineers to have to re-develop many common components multiple times. The vis-react components library was designed to help enable creating visualizations that are independent of the underlying data. This library utilizes the React.js pattern of instantiating components that may be re-used. The library exposes an example application that allows other developers to understand how to use the components in the library.

Correlation consistent basis sets for the atoms In–Xe

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mahler, Andrew; Wilson, Angela K., E-mail: akwilson@unt.edu

In this work, the correlation consistent family of Gaussian basis sets has been expanded to include all-electron basis sets for In–Xe. The methodology for developing these basis sets is described, and several examples of the performance and utility of the new sets have been provided. Dissociation energies and bond lengths for both homonuclear and heteronuclear diatomics demonstrate the systematic convergence behavior with respect to increasing basis set quality expected by the family of correlation consistent basis sets in describing molecular properties. Comparison with recently developed correlation consistent sets designed for use with the Douglas-Kroll Hamiltonian is provided.

Investigation of the Public Library as a Linking Agent to Major Scientific, Educational, Social and Environmental Data Bases. Two-Year Interim Report. Annex 2: Publicity Aspects.

ERIC Educational Resources Information Center

Summit, Roger K.; Firschein, Oscar

Project Dialib was a two-year investigation of the impact of on line information retrieval in a public library setting. This volume documents the efforts that were made to publicize the project and to promote the use of the service among library patrons. (JY)

36 CFR § 703.15 - Purpose and scope of this subpart.

Code of Federal Regulations, 2013 CFR

2013-07-01

... subpart. § 703.15 Section § 703.15 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR... Proceedings Where the Library Is Not a Party § 703.15 Purpose and scope of this subpart. This subpart sets forth the policy and procedures of the Library of Congress regarding, first, the testimony, as witnesses...

Planning and Strategy for Setting Up and Operating Academic Libraries in Temporary Quarters: Experiences of Two Northeast Colleges.

ERIC Educational Resources Information Center

Nelson, Garet; Stanley, Laurel; Eyman, David; Seiden, Peggy

The prospect of resolving a library's space and utilization problems through expansion and renovation carries with it the question of how to maintain operations during construction. Few libraries, especially those in the academic world, can afford to close their doors for very long, even though the prospect of maintaining ongoing operations amid…

Communication, Collaboration, and Enhancing the Learning Experience: Developing a Collaborative Virtual Enquiry Service in University Libraries in the North of England

ERIC Educational Resources Information Center

Jolly, Liz; White, Sue

2016-01-01

This article uses the case study of developing a collaborative "out-of-hours" virtual enquiry service by members of the Northern Collaboration Group of academic libraries in the north of England to explore the importance of communication and collaboration between academic library services in enhancing student learning. Set within the…

LINWORTH/ALISE 2009 Youth Services Paper: Equal Opportunity? Poverty and Characteristics of School Library Media Centers

ERIC Educational Resources Information Center

Pribesh, Shana; Gavigan, Karen

2009-01-01

When the authors met through a mutual colleague, Gail Dickinson at Old Dominion University, Karen and Shana set about to examine issues that do not normally interest sociologists--the number of days school libraries are closed and whether or not library schedules (fixed or flexed) impact student achievement. However, Shana, a sociologist who…

Creating Structured Collaboration in Implementing Assistive Technologies in a Community College Setting: Library Access, A Case Study.

ERIC Educational Resources Information Center

Norris, Marcia; Vasquez, Laurie

This paper discusses the role of libraries as the hub of information literacy in college and the need for professional collaboration to ensure library access for students with disabilities at California community college campuses. A working plan for developing assistive technology (AT) capabilities is provided which includes the following steps:…

LibHalfSpace: A C++ object-oriented library to study deformation and stress in elastic half-spaces

NASA Astrophysics Data System (ADS)

Ferrari, Claudio; Bonafede, Maurizio; Belardinelli, Maria Elina

2016-11-01

The study of deformation processes in elastic half-spaces is widely employed for many purposes (e.g. didactic, scientific investigation of real processes, inversion of geodetic data, etc.). We present a coherent programming interface containing a set of tools designed to make easier and faster the study of processes in an elastic half-space. LibHalfSpace is presented in the form of an object-oriented library. A set of well known and frequently used source models (Mogi source, penny shaped horizontal crack, inflating spheroid, Okada rectangular dislocation, etc.) are implemented to describe the potential usage and the versatility of the library. The common interface given to library tools enables us to switch easily among the effects produced by different deformation sources that can be monitored at the free surface. Furthermore, the library also offers an interface which simplifies the creation of new source models exploiting the features of object-oriented programming (OOP). These source models can be built as distributions of rectangular boundary elements. In order to better explain how new models can be deployed some examples are included in the library.

An Outreach Project to Provide 2.1 Million Eclipse Glasses and Eclipse Information through 7,100 Libraries Nationwide

NASA Astrophysics Data System (ADS)

Fraknoi, Andrew; Schatz, Dennis; Dusenbery, Paul; Duncan, Douglas; Holland, Anne; Laconte, Keliann

2018-01-01

With support from the Moore Foundation, Google, the Research Corporation, and NASA, we were able to distribute about 2.1 million eclipse glasses and an extensive booklet of eclipse information and outreach suggestions to 7,100 public libraries throughout the nation. It appears that this project was the single largest program to provide glasses and eclipse information to the public in the U.S. The project using (and significantly enlarged) the existing STARNet network of libraries set up and maintained by the Space Science Institute. We were able to get glasses to a diverse set of institutions, including urban, rural, Native American, small town and large city libraries. In this poster, we will summarize the history of the project, the various components and how they worked together, and the results of a post survey of the librarians, which provided numbers, photographs, and impressions from the many libraries and their patrons. A map of the libraries involved is at www.starnetlibraries.org/2017eclipse/. The booklet of information that was sent to help train librarians in eclipse science and eclipse outreach can still be downloaded free at: http://www.starnetlibraries.org/EclipseGuide/.”

The Georgetown University Library Information System (LIS): a minicomputer-based integrated library system.

PubMed Central

Broering, N C

1983-01-01

Georgetown University's Library Information System (LIS), an integrated library system designed and implemented at the Dahlgren Memorial Library, is broadly described from an administrative point of view. LIS' functional components consist of eight "user-friendly" modules: catalog, circulation, serials, bibliographic management (including Mini-MEDLINE), acquisitions, accounting, networking, and computer-assisted instruction. This article touches on emerging library services, user education, and computer information services, which are also changing the role of staff librarians. The computer's networking capability brings the library directly to users through personal or institutional computers at remote sites. The proposed Integrated Medical Center Information System at Georgetown University will include interface with LIS through a network mechanism. LIS is being replicated at other libraries, and a microcomputer version is being tested for use in a hospital setting. PMID:6688749

Open-Source Python Tools for Deploying Interactive GIS Dashboards for a Billion Datapoints on a Laptop

NASA Astrophysics Data System (ADS)

Steinberg, P. D.; Bednar, J. A.; Rudiger, P.; Stevens, J. L. R.; Ball, C. E.; Christensen, S. D.; Pothina, D.

2017-12-01

The rich variety of software libraries available in the Python scientific ecosystem provides a flexible and powerful alternative to traditional integrated GIS (geographic information system) programs. Each such library focuses on doing a certain set of general-purpose tasks well, and Python makes it relatively simple to glue the libraries together to solve a wide range of complex, open-ended problems in Earth science. However, choosing an appropriate set of libraries can be challenging, and it is difficult to predict how much "glue code" will be needed for any particular combination of libraries and tasks. Here we present a set of libraries that have been designed to work well together to build interactive analyses and visualizations of large geographic datasets, in standard web browsers. The resulting workflows run on ordinary laptops even for billions of data points, and easily scale up to larger compute clusters when available. The declarative top-level interface used in these libraries means that even complex, fully interactive applications can be built and deployed as web services using only a few dozen lines of code, making it simple to create and share custom interactive applications even for datasets too large for most traditional GIS systems. The libraries we will cover include GeoViews (HoloViews extended for geographic applications) for declaring visualizable/plottable objects, Bokeh for building visual web applications from GeoViews objects, Datashader for rendering arbitrarily large datasets faithfully as fixed-size images, Param for specifying user-modifiable parameters that model your domain, Xarray for computing with n-dimensional array data, Dask for flexibly dispatching computational tasks across processors, and Numba for compiling array-based Python code down to fast machine code. We will show how to use the resulting workflow with static datasets and with simulators such as GSSHA or AdH, allowing you to deploy flexible, high-performance web-based dashboards for your GIS data or simulations without needing major investments in code development or maintenance.

Pro Libra Makes the Impossible Happen.

ERIC Educational Resources Information Center

Cherry, Susan Spaeth

1981-01-01

Pro Libra Associates, Inc. in South Orange, New Jersey, is a cadre of some 200 carefully screened professionals and clerical workers who perform a variety of library tasks on a contract basis. (Author/LLS)

[Review of digital ground object spectral library].

PubMed

Zhou, Xiao-Hu; Zhou, Ding-Wu

2009-06-01

A higher spectral resolution is the main direction of developing remote sensing technology, and it is quite important to set up the digital ground object reflectance spectral database library, one of fundamental research fields in remote sensing application. Remote sensing application has been increasingly relying on ground object spectral characteristics, and quantitative analysis has been developed to a new stage. The present article summarized and systematically introduced the research status quo and development trend of digital ground object reflectance spectral libraries at home and in the world in recent years. Introducing the spectral libraries has been established, including desertification spectral database library, plants spectral database library, geological spectral database library, soil spectral database library, minerals spectral database library, cloud spectral database library, snow spectral database library, the atmosphere spectral database library, rocks spectral database library, water spectral database library, meteorites spectral database library, moon rock spectral database library, and man-made materials spectral database library, mixture spectral database library, volatile compounds spectral database library, and liquids spectral database library. In the process of establishing spectral database libraries, there have been some problems, such as the lack of uniform national spectral database standard and uniform standards for the ground object features as well as the comparability between different databases. In addition, data sharing mechanism can not be carried out, etc. This article also put forward some suggestions on those problems.

Use of Library Readings to Augment Conventional Geology Instruction.

ERIC Educational Resources Information Center

Nold, John Lloyd

1989-01-01

Examples of sets of questions on library readings designed to lead students into articles and emphasize important information and associated literature are presented for introductory geology courses, historical geology, structural geology, mineralogy, and petrology. (Author/CW)

YAP Version 4.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nelson, Eric M.

2004-05-20

The YAP software library computes (1) electromagnetic modes, (2) electrostatic fields, (3) magnetostatic fields and (4) particle trajectories in 2d and 3d models. The code employs finite element methods on unstructured grids of tetrahedral, hexahedral, prism and pyramid elements, with linear through cubic element shapes and basis functions to provide high accuracy. The novel particle tracker is robust, accurate and efficient, even on unstructured grids with discontinuous fields. This software library is a component of the MICHELLE 3d finite element gun code.

Analysis of Current DNA Encoded Library Screening Data Indicates Higher False Negative Rates for Numerically Larger Libraries.

PubMed

Satz, Alexander L; Hochstrasser, Remo; Petersen, Ann C

2017-04-10

To optimize future DNA-encoded library design, we have attempted to quantify the library size at which the signal becomes undetectable. To accomplish this we (i) have calculated that percent yields of individual library members following a screen range from 0.002 to 1%, (ii) extrapolated that ∼1 million copies per library member are required at the outset of a screen, and (iii) from this extrapolation predict that false negative rates will begin to outweigh the benefit of increased diversity at library sizes >10 8 . The above analysis is based upon a large internal data set comprising multiple screens, targets, and libraries; we also augmented our internal data with all currently available literature data. In theory, high false negative rates may be overcome by employing larger amounts of library; however, we argue that using more than currently reported amounts of library (≫10 nmoles) is impractical. The above conclusions may be generally applicable to other DNA encoded library platforms, particularly those platforms that do not allow for library amplification.

Push it to the limit: Characterizing the convergence of common sequences of basis sets for intermolecular interactions as described by density functional theory

NASA Astrophysics Data System (ADS)

Witte, Jonathon; Neaton, Jeffrey B.; Head-Gordon, Martin

2016-05-01

With the aim of systematically characterizing the convergence of common families of basis sets such that general recommendations for basis sets can be made, we have tested a wide variety of basis sets against complete-basis binding energies across the S22 set of intermolecular interactions—noncovalent interactions of small and medium-sized molecules consisting of first- and second-row atoms—with three distinct density functional approximations: SPW92, a form of local-density approximation; B3LYP, a global hybrid generalized gradient approximation; and B97M-V, a meta-generalized gradient approximation with nonlocal correlation. We have found that it is remarkably difficult to reach the basis set limit; for the methods and systems examined, the most complete basis is Jensen's pc-4. The Dunning correlation-consistent sequence of basis sets converges slowly relative to the Jensen sequence. The Karlsruhe basis sets are quite cost effective, particularly when a correction for basis set superposition error is applied: counterpoise-corrected def2-SVPD binding energies are better than corresponding energies computed in comparably sized Dunning and Jensen bases, and on par with uncorrected results in basis sets 3-4 times larger. These trends are exhibited regardless of the level of density functional approximation employed. A sense of the magnitude of the intrinsic incompleteness error of each basis set not only provides a foundation for guiding basis set choice in future studies but also facilitates quantitative comparison of existing studies on similar types of systems.

Psi4 1.1: An Open-Source Electronic Structure Program Emphasizing Automation, Advanced Libraries, and Interoperability.

PubMed

Parrish, Robert M; Burns, Lori A; Smith, Daniel G A; Simmonett, Andrew C; DePrince, A Eugene; Hohenstein, Edward G; Bozkaya, Uğur; Sokolov, Alexander Yu; Di Remigio, Roberto; Richard, Ryan M; Gonthier, Jérôme F; James, Andrew M; McAlexander, Harley R; Kumar, Ashutosh; Saitow, Masaaki; Wang, Xiao; Pritchard, Benjamin P; Verma, Prakash; Schaefer, Henry F; Patkowski, Konrad; King, Rollin A; Valeev, Edward F; Evangelista, Francesco A; Turney, Justin M; Crawford, T Daniel; Sherrill, C David

2017-07-11

Psi4 is an ab initio electronic structure program providing methods such as Hartree-Fock, density functional theory, configuration interaction, and coupled-cluster theory. The 1.1 release represents a major update meant to automate complex tasks, such as geometry optimization using complete-basis-set extrapolation or focal-point methods. Conversion of the top-level code to a Python module means that Psi4 can now be used in complex workflows alongside other Python tools. Several new features have been added with the aid of libraries providing easy access to techniques such as density fitting, Cholesky decomposition, and Laplace denominators. The build system has been completely rewritten to simplify interoperability with independent, reusable software components for quantum chemistry. Finally, a wide range of new theoretical methods and analyses have been added to the code base, including functional-group and open-shell symmetry adapted perturbation theory, density-fitted coupled cluster with frozen natural orbitals, orbital-optimized perturbation and coupled-cluster methods (e.g., OO-MP2 and OO-LCCD), density-fitted multiconfigurational self-consistent field, density cumulant functional theory, algebraic-diagrammatic construction excited states, improvements to the geometry optimizer, and the "X2C" approach to relativistic corrections, among many other improvements.

A first step in understanding an invasive weed through its genes: an EST analysis of invasive Centaurea maculosa.

PubMed

Broz, Amanda K; Broeckling, Corey D; He, Ji; Dai, Xinbin; Zhao, Patrick X; Vivanco, Jorge M

2007-05-24

The economic and biological implications of plant invasion are overwhelming; however, the processes by which plants become successful invaders are not well understood. Limited genetic resources are available for most invasive and weedy species, making it difficult to study molecular and genetic aspects that may be associated with invasion. As an initial step towards understanding the molecular mechanisms by which plants become invasive, we have generated a normalized Expressed Sequence Tag (EST) library comprising seven invasive populations of Centaurea maculosa, an invasive aster in North America. Seventy-seven percent of the 4423 unique transcripts showed significant similarity to existing proteins in the NCBI database and could be grouped based on gene ontology assignments. The C. maculosa EST library represents an initial step towards looking at gene-specific expression in this species, and will pave the way for creation of other resources such as microarray chips that can help provide a view of global gene expression in invasive C. maculosa and its native counterparts. To our knowledge, this is the first published set of ESTs derived from an invasive weed that will be targeted to study invasive behavior. Understanding the genetic basis of evolution for increased invasiveness in exotic plants is critical to understanding the mechanisms through which exotic invasions occur.

Application of Bayes' theorem for pulse shape discrimination

NASA Astrophysics Data System (ADS)

Monterial, Mateusz; Marleau, Peter; Clarke, Shaun; Pozzi, Sara

2015-09-01

A Bayesian approach is proposed for pulse shape discrimination of photons and neutrons in liquid organic scinitillators. Instead of drawing a decision boundary, each pulse is assigned a photon or neutron confidence probability. This allows for photon and neutron classification on an event-by-event basis. The sum of those confidence probabilities is used to estimate the number of photon and neutron instances in the data. An iterative scheme, similar to an expectation-maximization algorithm for Gaussian mixtures, is used to infer the ratio of photons-to-neutrons in each measurement. Therefore, the probability space adapts to data with varying photon-to-neutron ratios. A time-correlated measurement of Am-Be and separate measurements of 137Cs, 60Co and 232Th photon sources were used to construct libraries of neutrons and photons. These libraries were then used to produce synthetic data sets with varying ratios of photons-to-neutrons. Probability weighted method that we implemented was found to maintain neutron acceptance rate of up to 90% up to photon-to-neutron ratio of 2000, and performed 9% better than the decision boundary approach. Furthermore, the iterative approach appropriately changed the probability space with an increasing number of photons which kept the neutron population estimate from unrealistically increasing.

Application of Bayes' theorem for pulse shape discrimination

DOE PAGES

Marleau, Peter; Monterial, Mateusz; Clarke, Shaun; ...

2015-06-14

A Bayesian approach is proposed for pulse shape discrimination of photons and neutrons in liquid organic scinitillators. Instead of drawing a decision boundary, each pulse is assigned a photon or neutron confidence probability. In addition, this allows for photon and neutron classification on an event-by-event basis. The sum of those confidence probabilities is used to estimate the number of photon and neutron instances in the data. An iterative scheme, similar to an expectation-maximization algorithm for Gaussian mixtures, is used to infer the ratio of photons-to-neutrons in each measurement. Therefore, the probability space adapts to data with varying photon-to-neutron ratios. Amore » time-correlated measurement of Am–Be and separate measurements of 137Cs, 60Co and 232Th photon sources were used to construct libraries of neutrons and photons. These libraries were then used to produce synthetic data sets with varying ratios of photons-to-neutrons. Probability weighted method that we implemented was found to maintain neutron acceptance rate of up to 90% up to photon-to-neutron ratio of 2000, and performed 9% better than the decision boundary approach. Furthermore, the iterative approach appropriately changed the probability space with an increasing number of photons which kept the neutron population estimate from unrealistically increasing.« less

Costs and Their Assessment to Users of a Medical Library, Part II: Recovering Costs from Service Usage.

ERIC Educational Resources Information Center

Bres, E.; And Others

Part II of the study describes a model for associating one portion of total library costs with use; the model's output is a set of charges that can be used to recover (justify) these usage-based costs. Algebraic formulations constructed and combined to form the model are a set of service charges that may vary by user type and recover out-of-pocket…

Psychological Problems of Normal Aging: Implications for Public Library Service.

ERIC Educational Resources Information Center

Wiley, Mary Dale

Few people are conditioned in the middle years to cope with the prospect of old age and retirement. If public libraries could act as the liaison in this transition, perhaps more people would be prepared to lead productive lives after age 65. Public libraries set aside sections for children and young adults but fail to do the same for the elderly.…

Introducing Public Libraries to The Big Read: Final Report on the Audio Guide Distribution

ERIC Educational Resources Information Center

Sloan, Kay; Randall, Michelle

2009-01-01

In July 2008, over 14,000 public libraries throughout the U.S. received, free of charge, a set of fourteen Audio Guides introducing them to The Big Read. Since 2007, when the National Endowment for the Arts and the Institute of Museum and Library Services, in partnership with Arts Midwest, debuted The Big Read, the program has awarded grants to…

St. Louis Regional Library Network Manuals: Delivery System Manual, INFO-PASS Manual, Interlibrary Loan Protocol, Procedures and Policies Manual.

ERIC Educational Resources Information Center

Saint Louis Regional Library Network, MO.

Included in this set of manuals are: (1) guidelines for document delivery to member libraries within the St. Louis Regional Library Network (SLRLN) in which eligible materials are described, addressing and packing are outlined, routing and deliveries are discussed, and a list of delivery system participants is provided; (2) a descriptive guide to…

Bookbabies, Their Parents and the Library: An Evaluation of a Flemish Reading Programme in Families with Young Children

ERIC Educational Resources Information Center

Vanobbergen, Bruno; Daems, Marie; Van Tilburg, Sarah

2009-01-01

Bookbabies, an initiative from the Flemish Reading Association and the Flemish Centre for Public Libraries, is a pilot project organised in 10 Flemish cities where local public libraries worked together with 82 couples with young babies for two years to set up a programme called "having fun with books". The objectives of the research…

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update.

PubMed

Kuleshov, Maxim V; Jones, Matthew R; Rouillard, Andrew D; Fernandez, Nicolas F; Duan, Qiaonan; Wang, Zichen; Koplev, Simon; Jenkins, Sherry L; Jagodnik, Kathleen M; Lachmann, Alexander; McDermott, Michael G; Monteiro, Caroline D; Gundersen, Gregory W; Ma'ayan, Avi

2016-07-08

Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr. Enrichr currently contains a large collection of diverse gene set libraries available for analysis and download. In total, Enrichr currently contains 180 184 annotated gene sets from 102 gene set libraries. New features have been added to Enrichr including the ability to submit fuzzy sets, upload BED files, improved application programming interface and visualization of the results as clustergrams. Overall, Enrichr is a comprehensive resource for curated gene sets and a search engine that accumulates biological knowledge for further biological discoveries. Enrichr is freely available at: http://amp.pharm.mssm.edu/Enrichr. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

The simulation library of the Belle II software system

NASA Astrophysics Data System (ADS)

Kim, D. Y.; Ritter, M.; Bilka, T.; Bobrov, A.; Casarosa, G.; Chilikin, K.; Ferber, T.; Godang, R.; Jaegle, I.; Kandra, J.; Kodys, P.; Kuhr, T.; Kvasnicka, P.; Nakayama, H.; Piilonen, L.; Pulvermacher, C.; Santelj, L.; Schwenker, B.; Sibidanov, A.; Soloviev, Y.; Starič, M.; Uglov, T.

2017-10-01

SuperKEKB, the next generation B factory, has been constructed in Japan as an upgrade of KEKB. This brand new e+ e- collider is expected to deliver a very large data set for the Belle II experiment, which will be 50 times larger than the previous Belle sample. Both the triggered physics event rate and the background event rate will be increased by at least 10 times than the previous ones, and will create a challenging data taking environment for the Belle II detector. The software system of the Belle II experiment is designed to execute this ambitious plan. A full detector simulation library, which is a part of the Belle II software system, is created based on Geant4 and has been tested thoroughly. Recently the library has been upgraded with Geant4 version 10.1. The library is behaving as expected and it is utilized actively in producing Monte Carlo data sets for various studies. In this paper, we will explain the structure of the simulation library and the various interfaces to other packages including geometry and beam background simulation.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Witte, Jonathon; Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, California 94720; Neaton, Jeffrey B.

With the aim of systematically characterizing the convergence of common families of basis sets such that general recommendations for basis sets can be made, we have tested a wide variety of basis sets against complete-basis binding energies across the S22 set of intermolecular interactions—noncovalent interactions of small and medium-sized molecules consisting of first- and second-row atoms—with three distinct density functional approximations: SPW92, a form of local-density approximation; B3LYP, a global hybrid generalized gradient approximation; and B97M-V, a meta-generalized gradient approximation with nonlocal correlation. We have found that it is remarkably difficult to reach the basis set limit; for the methodsmore » and systems examined, the most complete basis is Jensen’s pc-4. The Dunning correlation-consistent sequence of basis sets converges slowly relative to the Jensen sequence. The Karlsruhe basis sets are quite cost effective, particularly when a correction for basis set superposition error is applied: counterpoise-corrected def2-SVPD binding energies are better than corresponding energies computed in comparably sized Dunning and Jensen bases, and on par with uncorrected results in basis sets 3-4 times larger. These trends are exhibited regardless of the level of density functional approximation employed. A sense of the magnitude of the intrinsic incompleteness error of each basis set not only provides a foundation for guiding basis set choice in future studies but also facilitates quantitative comparison of existing studies on similar types of systems.« less

NASA's Coordinated Efforts to Enhance STEM Education: Bringing NASA Science into the Library

NASA Astrophysics Data System (ADS)

Meinke, B. K.; Thomas, C.; Eyermann, S.; Mitchell, S.; LaConte, K.; Hauck, K.

2015-11-01

Libraries are community-centered, free-access venues serving learners of all ages and backgrounds. Libraries also recognize the importance of science literacy and strive to include science in their programming portfolio. Scientists and educators can partner with local libraries to advance mutual goals of connecting the public to Earth and Space Science. In this interactive Special Interest Group (SIG) discussion, representatives from the NASA Science Mission Directorate (SMD) Education and Public Outreach (EPO) community's library collaborations discussed the opportunities for partnership with public and school libraries; explored the resources, events, and programs available through libraries; explored NASA science programming and professional development opportunities available for librarians; and strategized about the types of support that librarians require to plan and implement programs that use NASA data and resources. We also shared successes, lessons learned, and future opportunities for incorporating NASA science programming into library settings.

Development and testing of the VITAMIN-B7/BUGLE-B7 coupled neutron-gamma multigroup cross-section libraries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Risner, J.M.; Wiarda, D.; Miller, T.M.

2011-07-01

The U.S. Nuclear Regulatory Commission's Regulatory Guide 1.190 states that calculational methods used to estimate reactor pressure vessel (RPV) fluence should use the latest version of the evaluated nuclear data file (ENDF). The VITAMIN-B6 fine-group library and BUGLE-96 broad-group library, which are widely used for RPV fluence calculations, were generated using ENDF/B-VI.3 data, which was the most current data when Regulatory Guide 1.190 was issued. We have developed new fine-group (VITAMIN-B7) and broad-group (BUGLE-B7) libraries based on ENDF/B-VII.0. These new libraries, which were processed using the AMPX code system, maintain the same group structures as the VITAMIN-B6 and BUGLE-96 libraries.more » Verification and validation of the new libraries were accomplished using diagnostic checks in AMPX, 'unit tests' for each element in VITAMIN-B7, and a diverse set of benchmark experiments including critical evaluations for fast and thermal systems, a set of experimental benchmarks that are used for SCALE regression tests, and three RPV fluence benchmarks. The benchmark evaluation results demonstrate that VITAMIN-B7 and BUGLE-B7 are appropriate for use in RPV fluence calculations and meet the calculational uncertainty criterion in Regulatory Guide 1.190. (authors)« less

Development and Testing of the VITAMIN-B7/BUGLE-B7 Coupled Neutron-Gamma Multigroup Cross-Section Libraries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Risner, Joel M; Wiarda, Dorothea; Miller, Thomas Martin

2011-01-01

The U.S. Nuclear Regulatory Commission s Regulatory Guide 1.190 states that calculational methods used to estimate reactor pressure vessel (RPV) fluence should use the latest version of the Evaluated Nuclear Data File (ENDF). The VITAMIN-B6 fine-group library and BUGLE-96 broad-group library, which are widely used for RPV fluence calculations, were generated using ENDF/B-VI data, which was the most current data when Regulatory Guide 1.190 was issued. We have developed new fine-group (VITAMIN-B7) and broad-group (BUGLE-B7) libraries based on ENDF/B-VII. These new libraries, which were processed using the AMPX code system, maintain the same group structures as the VITAMIN-B6 and BUGLE-96more » libraries. Verification and validation of the new libraries was accomplished using diagnostic checks in AMPX, unit tests for each element in VITAMIN-B7, and a diverse set of benchmark experiments including critical evaluations for fast and thermal systems, a set of experimental benchmarks that are used for SCALE regression tests, and three RPV fluence benchmarks. The benchmark evaluation results demonstrate that VITAMIN-B7 and BUGLE-B7 are appropriate for use in LWR shielding applications, and meet the calculational uncertainty criterion in Regulatory Guide 1.190.« less

Computational annotation of genes differentially expressed along olive fruit development

PubMed Central

Galla, Giulio; Barcaccia, Gianni; Ramina, Angelo; Collani, Silvio; Alagna, Fiammetta; Baldoni, Luciana; Cultrera, Nicolò GM; Martinelli, Federico; Sebastiani, Luca; Tonutti, Pietro

2009-01-01

Background Olea europaea L. is a traditional tree crop of the Mediterranean basin with a worldwide economical high impact. Differently from other fruit tree species, little is known about the physiological and molecular basis of the olive fruit development and a few sequences of genes and gene products are available for olive in public databases. This study deals with the identification of large sets of differentially expressed genes in developing olive fruits and the subsequent computational annotation by means of different software. Results mRNA from fruits of the cv. Leccino sampled at three different stages [i.e., initial fruit set (stage 1), completed pit hardening (stage 2) and veraison (stage 3)] was used for the identification of differentially expressed genes putatively involved in main processes along fruit development. Four subtractive hybridization libraries were constructed: forward and reverse between stage 1 and 2 (libraries A and B), and 2 and 3 (libraries C and D). All sequenced clones (1,132 in total) were analyzed through BlastX against non-redundant NCBI databases and about 60% of them showed similarity to known proteins. A total of 89 out of 642 differentially expressed unique sequences was further investigated by Real-Time PCR, showing a validation of the SSH results as high as 69%. Library-specific cDNA repertories were annotated according to the three main vocabularies of the gene ontology (GO): cellular component, biological process and molecular function. BlastX analysis, GO terms mapping and annotation analysis were performed using the Blast2GO software, a research tool designed with the main purpose of enabling GO based data mining on sequence sets for which no GO annotation is yet available. Bioinformatic analysis pointed out a significantly different distribution of the annotated sequences for each GO category, when comparing the three fruit developmental stages. The olive fruit-specific transcriptome dataset was used to query all known KEGG (Kyoto Encyclopaedia of Genes and Genomes) metabolic pathways for characterizing and positioning retrieved EST records. The integration of the olive sequence datasets within the MapMan platform for microarray analysis allowed the identification of specific biosynthetic pathways useful for the definition of key functional categories in time course analyses for gene groups. Conclusion The bioinformatic annotation of all gene sequences was useful to shed light on metabolic pathways and transcriptional aspects related to carbohydrates, fatty acids, secondary metabolites, transcription factors and hormones as well as response to biotic and abiotic stresses throughout olive drupe development. These results represent a first step toward both functional genomics and systems biology research for understanding the gene functions and regulatory networks in olive fruit growth and ripening. PMID:19852839

Accuracy of Lagrange-sinc functions as a basis set for electronic structure calculations of atoms and molecules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Choi, Sunghwan; Hong, Kwangwoo; Kim, Jaewook

2015-03-07

We developed a self-consistent field program based on Kohn-Sham density functional theory using Lagrange-sinc functions as a basis set and examined its numerical accuracy for atoms and molecules through comparison with the results of Gaussian basis sets. The result of the Kohn-Sham inversion formula from the Lagrange-sinc basis set manifests that the pseudopotential method is essential for cost-effective calculations. The Lagrange-sinc basis set shows faster convergence of the kinetic and correlation energies of benzene as its size increases than the finite difference method does, though both share the same uniform grid. Using a scaling factor smaller than or equal tomore » 0.226 bohr and pseudopotentials with nonlinear core correction, its accuracy for the atomization energies of the G2-1 set is comparable to all-electron complete basis set limits (mean absolute deviation ≤1 kcal/mol). The same basis set also shows small mean absolute deviations in the ionization energies, electron affinities, and static polarizabilities of atoms in the G2-1 set. In particular, the Lagrange-sinc basis set shows high accuracy with rapid convergence in describing density or orbital changes by an external electric field. Moreover, the Lagrange-sinc basis set can readily improve its accuracy toward a complete basis set limit by simply decreasing the scaling factor regardless of systems.« less

Health sciences libraries: strategies in an era of changing economics.

PubMed Central

Messerle, J

1987-01-01

Libraries in health care settings reflect their parent institutions, which, in turn, are affected by environmental changes. The economic climate of the 1980s, unleashing competitive forces and threatening the survival of some institutions, has had a major impact on both hospitals and academic health centers. The challenge to libraries of these institutions calls for reassessment of programs and realignment in their power structures. It is argued that libraries which position themselves to capitalize on the current economic environment will create a future with new opportunities. PMID:3828607

Optimization of selected molecular orbitals in group basis sets.

PubMed

Ferenczy, György G; Adams, William H

2009-04-07

We derive a local basis equation which may be used to determine the orbitals of a group of electrons in a system when the orbitals of that group are represented by a group basis set, i.e., not the basis set one would normally use but a subset suited to a specific electronic group. The group orbitals determined by the local basis equation minimize the energy of a system when a group basis set is used and the orbitals of other groups are frozen. In contrast, under the constraint of a group basis set, the group orbitals satisfying the Huzinaga equation do not minimize the energy. In a test of the local basis equation on HCl, the group basis set included only 12 of the 21 functions in a basis set one might ordinarily use, but the calculated active orbital energies were within 0.001 hartree of the values obtained by solving the Hartree-Fock-Roothaan (HFR) equation using all 21 basis functions. The total energy found was just 0.003 hartree higher than the HFR value. The errors with the group basis set approximation to the Huzinaga equation were larger by over two orders of magnitude. Similar results were obtained for PCl(3) with the group basis approximation. Retaining more basis functions allows an even higher accuracy as shown by the perfect reproduction of the HFR energy of HCl with 16 out of 21 basis functions in the valence basis set. When the core basis set was also truncated then no additional error was introduced in the calculations performed for HCl with various basis sets. The same calculations with fixed core orbitals taken from isolated heavy atoms added a small error of about 10(-4) hartree. This offers a practical way to calculate wave functions with predetermined fixed core and reduced base valence orbitals at reduced computational costs. The local basis equation can also be used to combine the above approximations with the assignment of local basis sets to groups of localized valence molecular orbitals and to derive a priori localized orbitals. An appropriately chosen localization and basis set assignment allowed a reproduction of the energy of n-hexane with an error of 10(-5) hartree, while the energy difference between its two conformers was reproduced with a similar accuracy for several combinations of localizations and basis set assignments. These calculations include localized orbitals extending to 4-5 heavy atoms and thus they require to solve reduced dimension secular equations. The dimensions are not expected to increase with increasing system size and thus the local basis equation may find use in linear scaling electronic structure calculations.

Academic health sciences library Website navigation: an analysis of forty-one Websites and their navigation tools

PubMed Central

Brower, Stewart M.

2004-01-01

Background: The analysis included forty-one academic health sciences library (HSL) Websites as captured in the first two weeks of January 2001. Home pages and persistent navigational tools (PNTs) were analyzed for layout, technology, and links, and other general site metrics were taken. Methods: Websites were selected based on rank in the National Network of Libraries of Medicine, with regional and resource libraries given preference on the basis that these libraries are recognized as leaders in their regions and would be the most reasonable source of standards for best practice. A three-page evaluation tool was developed based on previous similar studies. All forty-one sites were evaluated in four specific areas: library general information, Website aids and tools, library services, and electronic resources. Metrics taken for electronic resources included orientation of bibliographic databases alphabetically by title or by subject area and with links to specifically named databases. Results: Based on the results, a formula for determining obligatory links was developed, listing items that should appear on all academic HSL Web home pages and PNTs. Conclusions: These obligatory links demonstrate a series of best practices that may be followed in the design and construction of academic HSL Websites. PMID:15494756

Innovation, engagement and development: moving forward in health information settings.

PubMed

Spring, Hannah

2018-06-08

The current trends influencing change in health information and library settings are presenting some exciting new opportunities for health information specialists. Increasingly, knowledge specialists are playing a pivotal role in the effective mobilisation of knowledge and evidence. The focus for our profession will continue to be on demonstrating the value and impact of our services, but a shift in expectations about how those services are delivered will need to be underpinned by new tools and skill sets. These issues are reflected in the themes of the Health Libraries Group 2018 conference, and in conjunction with the event, this virtual issue draws together a collection of articles reflecting those themes. Topics covered in the virtual issue include the following: Toolkits, online systems and emergent technologies to support health information practice; Continuing professional development; Community projects, engagement, outreach and public health; Value and impact and evidence-based practice; Service improvement and library management; and Digital and health literacy. The papers selected for this issue provide some excellent examples of how we, as a profession, are initiating change in creative ways and rising to the exciting challenges of the future. © 2018 Health Libraries Group.

Challenges of Working in a Multicultural Environment.

ERIC Educational Resources Information Center

Howland, Joan S.

2001-01-01

Addresses challenges faced when working in a multicultural library setting and discusses the need for library administration to create supportive environments. Highlights include fluctuating power dynamics; merging diverse opinions and approaches; overcoming perceived lack of empathy; tokenism; accountability; and transforming challenges into…

DiffPy-CMI-Python libraries for Complex Modeling Initiative

DOE Office of Scientific and Technical Information (OSTI.GOV)

Billinge, Simon; Juhas, Pavol; Farrow, Christopher

2014-02-01

Software to manipulate and describe crystal and molecular structures and set up structural refinements from multiple experimental inputs. Calculation and simulation of structure derived physical quantities. Library for creating customized refinements of atomic structures from available experimental and theoretical inputs.

Book Discounts and Cost-Plus Pricing

ERIC Educational Resources Information Center

Andresen, David C.

1974-01-01

The adoption of cost-plus pricing by a major book jobber may have profound effects on the discounts that libraries receive. The article explains the pricing system and presents a set of graphs for libraries to use to determine its effects. (Author)

Western Michigan University Libraries' "Electronic Journal Finder"

ERIC Educational Resources Information Center

Gedeon, Randle; Boston, George

2005-01-01

This article describes the development of the "Electronic Journal Finder," a TDNet installation for the University Libraries of Western Michigan University. Topics covered include: rationale for subscription project timeline, content, product customization, set-up, maintenance issues, reporting functions, directing URL links, searching…

Accurate Methods for Large Molecular Systems (Preprint)

DTIC Science & Technology

2009-01-06

tensor, EFP calculations are basis set dependent. The smallest recommended basis set is 6- 31++G( d , p )52 The dependence of the computational cost of...and second order perturbation theory (MP2) levels with the 6-31G( d , p ) basis set. Additional SFM tests are presented for a small set of alpha...helices using the 6-31++G( d , p ) basis set. The larger 6-311++G(3df,2p) basis set is employed for creating all EFPs used for non- bonded interactions, since

Postprocessing of Voxel-Based Topologies for Additive Manufacturing Using the Computational Geometry Algorithms Library (CGAL)

DTIC Science & Technology

2015-06-01

10-2014 to 00-11-2014 4. TITLE AND SUBTITLE Postprocessing of Voxel-Based Topologies for Additive Manufacturing Using the Computational Geometry...ABSTRACT Postprocessing of 3-dimensional (3-D) topologies that are defined as a set of voxels using the Computational Geometry Algorithms Library (CGAL... computational geometry algorithms, several of which are suited to the task. The work flow described in this report involves first defining a set of

Making lemonade from lemons: a case study on loss of space at the Dolph Briscoe, Jr. Library, University of Texas Health Science Center at San Antonio.

PubMed

Tobia, Rajia C; Feldman, Jonquil D

2010-01-01

The setting for this case study is the Dolph Briscoe, Jr. Library, University of Texas Health Science Center at San Antonio, a health sciences campus with medical, dental, nursing, health professions, and graduate schools. During 2008-2009, major renovations to the library building were completed including office space for a faculty development department, multipurpose classrooms, a 24/7 study area, study rooms, library staff office space, and an information commons. The impetus for changes to the library building was the decreasing need to house collections in an increasingly electronic environment, the need for office space for other departments, and growth of the student body. About 40% of the library building was remodeled or repurposed, with a loss of approximately 25% of the library's original space. Campus administration proposed changes to the library building, and librarians worked with administration, architects, and construction managers to seek renovation solutions that meshed with the library's educational mission.

Making lemonade from lemons: a case study on loss of space at the Dolph Briscoe, Jr. Library, University of Texas Health Science Center at San Antonio

PubMed Central

Tobia, Rajia C.; Feldman, Jonquil D.

2010-01-01

The setting for this case study is the Dolph Briscoe, Jr. Library, University of Texas Health Science Center at San Antonio, a health sciences campus with medical, dental, nursing, health professions, and graduate schools. During 2008–2009, major renovations to the library building were completed including office space for a faculty development department, multipurpose classrooms, a 24/7 study area, study rooms, library staff office space, and an information commons. The impetus for changes to the library building was the decreasing need to house collections in an increasingly electronic environment, the need for office space for other departments, and growth of the student body. About 40% of the library building was remodeled or repurposed, with a loss of approximately 25% of the library's original space. Campus administration proposed changes to the library building, and librarians worked with administration, architects, and construction managers to seek renovation solutions that meshed with the library's educational mission. PMID:20098652

[Physiology in the mirror of systematic catalogue of Russian Academy of Sciences Library].

PubMed

Orlov, I V; Lazurkina, V B

2011-07-01

Representation of general human and animal physiology publications in the systematic catalogue of the Library of the Russian Academy of Sciences is considered. The organization of the catalogue as applied to the problems of physiology, built on the basis of library-bibliographic classification used in the Russian universal scientific libraries is described. The card files of the systematic catalogue of the Library contain about 8 million cards. Topics that reflect the problems of general physiology contain 39 headings. For the full range of sciences including physiology the tables of general types of divisions were developed. They have been marked by indexes using lower-case letters of the Russian alphabet. For further detalizations of these indexes decimal symbols are used. The indexes are attached directly to the field of knowledge index. With the current relatively easy availability of network resources value and relevance of any catalogue are reduced. However it concerns much more journal articles, rather than reference books, proceedings of various conferences, bibliographies, personalities, and especially the monographs contained in the systematic catalogue. The card systematic catalogue of the Library remains an important source of information on general physiology issues, as well as its magistral narrower sections.

Use of Data Libraries for IAEA Nuclear Security Assessment Methodologies (NUSAM) [section 5.4

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shull, D.; Lane, M.

2015-06-23

Data libraries are essential for the characterization of the facility and provide the documented input which enables the facility assessment results and subsequent conclusions. Data Libraries are historical, verifiable, quantified, and applicable collections of testing data on different types of barriers, sensors, cameras, procedures, and/or personnel. Data libraries are developed and maintained as part of any assessment program or process. Data is collected during the initial stages of facility characterization to aid in the model and/or simulation development process. Data library values may also be developed through the use of state testing centers and/or site resources by testing different typesmore » of barriers, sensors, cameras, procedures, and/or personnel. If no data exists, subject matter expert opinion and manufacturer's specifications/ testing values can be the basis for initially assigning values, but are generally less reliable and lack appropriate confidence measures. The use of existing data libraries that have been developed by a state testing organization reduces the assessment costs by establishing standard delay, detection and assessment values for use by multiple sites or facilities where common barriers and alarms systems exist.« less

International Federation of Library Associations Annual Conference Papers. Collections and Services Division: Interlending, Rare and Precious Books, and Exchange and Acquisition Sections (47th, Leipzig, East Germany, August 17-22, 1981).

ERIC Educational Resources Information Center

Line, Maurice B.; And Others

This set of papers presented to the Collections and Services Division of the International Federation of Library Associations at its 47th annual conference (1981) includes: "Planning Interlending Systems in Developing Countries," by Maurice B. Line; "Problems of Centralisation of Inter-Library Lending in a De-Centralized Library…

The Library's Public Revisited, By Members of the Class in The Public Library in the Political Process.

ERIC Educational Resources Information Center

Bundy, Mary Lee, Ed.; Goodstein, Sylvia, Ed.

A group of students in the course dealt with the fundamental question of the public library's role in satisfying societal needs. Each of the students set out to explore the family, social, occupational and political world of an important social group. Members of two of the groups - the urban Negro and the blue collar worker - appeared to be either…

The Chandra X-ray Observatory PSF Library

NASA Astrophysics Data System (ADS)

Karovska, M.; Beikman, S. J.; Elvis, M. S.; Flanagan, J. M.; Gaetz, T.; Glotfelty, K. J.; Jerius, D.; McDowell, J. C.; Rots, A. H.

Pre-flight and on-orbit calibration of the Chandra X-Ray Observatory provided a unique base for developing detailed models of the optics and detectors. Using these models we have produced a set of simulations of the Chandra point spread function (PSF) which is available to the users via PSF library files. We describe here how the PSF models are generated and the design and content of the Chandra PSF library files.

Sequence evaluation of four specific cDNA libraries for developmental genomics of sunflower.

PubMed

Tamborindeguy, C; Ben, C; Liboz, T; Gentzbittel, L

2004-04-01

Four different cDNA libraries were constructed from sunflower protoplasts growing under embryogenic and non-embryogenic conditions: one standard library from each condition and two subtractive libraries in opposite sense. A total of 22,876 cDNA clones were obtained and 4800 ESTs were sequenced, giving rise to 2479 high quality ESTs representing an unigene set of 1502 sequences. This set was compared with ESTs represented in public databases using the programs BLASTN and BLASTX, and its members were classified according to putative function using the catalog in the Kyoto Encyclopedia of Genes and Genomes (KEGG). Some 33% of sequences failed to align with existing plant ESTs and therefore represent putative novel genes. The libraries show a low level of redundancy and, on average, 50% of the present ESTs have not been previously reported for sunflower. Several potentially interesting genes were identified, based on their homology with genes involved in animal zygotic division or plant embryogenesis. We also identified two ESTs that show significantly different levels of expression under embryogenic and non-embryogenic conditions. The libraries described here represent an original and valuable resource for the discovery of yet unknown genes putatively involved in dicot embryogenesis and improving our knowledge of the mechanisms involved in polarity acquisition by plant embryos.

Approaching the theoretical limit in periodic local MP2 calculations with atomic-orbital basis sets: the case of LiH.

PubMed

Usvyat, Denis; Civalleri, Bartolomeo; Maschio, Lorenzo; Dovesi, Roberto; Pisani, Cesare; Schütz, Martin

2011-06-07

The atomic orbital basis set limit is approached in periodic correlated calculations for solid LiH. The valence correlation energy is evaluated at the level of the local periodic second order Møller-Plesset perturbation theory (MP2), using basis sets of progressively increasing size, and also employing "bond"-centered basis functions in addition to the standard atom-centered ones. Extended basis sets, which contain linear dependencies, are processed only at the MP2 stage via a dual basis set scheme. The local approximation (domain) error has been consistently eliminated by expanding the orbital excitation domains. As a final result, it is demonstrated that the complete basis set limit can be reached for both HF and local MP2 periodic calculations, and a general scheme is outlined for the definition of high-quality atomic-orbital basis sets for solids. © 2011 American Institute of Physics

An expanded calibration study of the explicitly correlated CCSD(T)-F12b method using large basis set standard CCSD(T) atomization energies.

PubMed

Feller, David; Peterson, Kirk A

2013-08-28

The effectiveness of the recently developed, explicitly correlated coupled cluster method CCSD(T)-F12b is examined in terms of its ability to reproduce atomization energies derived from complete basis set extrapolations of standard CCSD(T). Most of the standard method findings were obtained with aug-cc-pV7Z or aug-cc-pV8Z basis sets. For a few homonuclear diatomic molecules it was possible to push the basis set to the aug-cc-pV9Z level. F12b calculations were performed with the cc-pVnZ-F12 (n = D, T, Q) basis set sequence and were also extrapolated to the basis set limit using a Schwenke-style, parameterized formula. A systematic bias was observed in the F12b method with the (VTZ-F12/VQZ-F12) basis set combination. This bias resulted in the underestimation of reference values associated with small molecules (valence correlation energies <0.5 E(h)) and an even larger overestimation of atomization energies for bigger systems. Consequently, caution should be exercised in the use of F12b for high accuracy studies. Root mean square and mean absolute deviation error metrics for this basis set combination were comparable to complete basis set values obtained with standard CCSD(T) and the aug-cc-pVDZ through aug-cc-pVQZ basis set sequence. However, the mean signed deviation was an order of magnitude larger. Problems partially due to basis set superposition error were identified with second row compounds which resulted in a weak performance for the smaller VDZ-F12/VTZ-F12 combination of basis sets.

Using open-source programs to create a web-based portal for hydrologic information

NASA Astrophysics Data System (ADS)

Kim, H.

2013-12-01

Some hydrologic data sets, such as basin climatology, precipitation, and terrestrial water storage, are not easily obtainable and distributable due to their size and complexity. We present a Hydrologic Information Portal (HIP) that has been implemented at the University of California for Hydrologic Modeling (UCCHM) and that has been organized around the large river basins of North America. This portal can be easily accessed through a modern web browser that enables easy access and visualization of such hydrologic data sets. Some of the main features of our HIP include a set of data visualization features so that users can search, retrieve, analyze, integrate, organize, and map data within large river basins. Recent information technologies such as Google Maps, Tornado (Python asynchronous web server), NumPy/SciPy (Scientific Library for Python) and d3.js (Visualization library for JavaScript) were incorporated into the HIP to create ease in navigating large data sets. With such open source libraries, HIP can give public users a way to combine and explore various data sets by generating multiple chart types (Line, Bar, Pie, Scatter plot) directly from the Google Maps viewport. Every rendered object such as a basin shape on the viewport is clickable, and this is the first step to access the visualization of data sets.

Eliciting positive, negative and mixed emotional states: A film library for affective scientists.

PubMed

Samson, Andrea C; Kreibig, Sylvia D; Soderstrom, Blake; Wade, A Ayanna; Gross, James J

2016-08-01

We describe the creation of a film library designed for researchers interested in positive (amusing), negative (repulsive), mixed (amusing and repulsive) and neutral emotional states. Three hundred 20- to 33-second film clips videotaped by amateurs were selected from video-hosting websites and screened in laboratory studies by 75 female participants on self-reported amusement and repulsion (Experiments 1 and 2). On the basis of pre-defined cut-off values, 51 positive, 39 negative, 59 mixed and 50 neutral film clips were selected. These film clips were then presented to 411 male and female participants in a large online study to identify film clips that reliably induced the target emotions (Experiment 3). Depending on the goal of the study, researchers may choose positive, negative, mixed or neutral emotional film clips on the basis of Experiments 1 and 2 or Experiment 3 ratings.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Arion is a library and tool set that enables researchers to holistically define test system models. To define a complex system for testing an algorithm or control requires expertise across multiple domains. Simulating a complex system requires the integration of multiple simulators and test hardware, each with their own specification languages and concepts. This requires extensive set of knowledge and capabilities. Arion was developed to alleviate this challenge. Arion is a library of Java libraries that abstracts the concepts from supported simulators into a cohesive model language that allows someone to build models to their needed level of fidelity andmore » expertise. Arion is also a software tool that translates the users model back into the specification languages of the simulators and test hardware needed for execution.« less

Tampa Bay Study Data and Information Management System (DIMS)

NASA Astrophysics Data System (ADS)

Edgar, N. T.; Johnston, J. B.; Yates, K.; Smith, K. E.

2005-05-01

Providing easy access to data and information is an essential component of both science and management. The Tampa Bay Data and Information Management System (DIMS) catalogs and publicizes data and products which are generated through the Tampa Bay Integrated Science Study. The publicly accessible interface consists of a Web site (http://gulfsci.usgs.gov), a digital library, and an interactive map server (IMS). The Tampa Bay Study Web site contains information from scientists involved in the study, and is also the portal site for the digital library and IMS. Study information is highlighted on the Web site according to the estuarine component: geology and geomorphology, water and sediment quality, ecosystem structure and function, and hydrodynamics. The Tampa Bay Digital Library is a web-based clearinghouse for digital products on Tampa Bay, including documents, maps, spatial and tabular data sets, presentations, etc. New developments to the digital library include new search features, 150 new products over the past year, and partnerships to expand the offering of science products. The IMS is a Web-based geographic information system (GIS) used to store, analyze and display data pertaining to Tampa Bay. Upgrades to the IMS have improved performance and speed, as well as increased the number of data sets available for mapping. The Tampa Bay DIMS is a dynamic entity and will continue to evolve with the study. Beginning in 2005, the Tampa Bay Integrated Coastal Model will have a more prominent presence within the DIMS. The Web site will feature model projects and plans; the digital library will host model products and data sets; the IMS will display spatial model data sets and analyses. These tools will be used to increase communication of USGS efforts in Tampa Bay to the public, local managers, and scientists.

Feasibility of retrofitting a university library with active workstations to reduce sedentary behavior.

PubMed

Maeda, Hotaka; Quartiroli, Alessandro; Vos, Paul W; Carr, Lucas J; Mahar, Matthew T

2014-05-01

Libraries are an inherently sedentary environment, but are an understudied setting for sedentary behavior interventions. To investigate the feasibility of incorporating portable pedal machines in a university library to reduce sedentary behaviors. The 11-week intervention targeted students at a university library. Thirteen portable pedal machines were placed in the library. Four forms of prompts (e-mail, library website, advertisement monitors, and poster) encouraging pedal machine use were employed during the first 4 weeks. Pedal machine use was measured via automatic timers on each machine and momentary time sampling. Daily library visits were measured using a gate counter. Individualized data were measured by survey. Data were collected in fall 2012 and analyzed in 2013. Mean (SD) cumulative pedal time per day was 95.5 (66.1) minutes. One or more pedal machines were observed being used 15% of the time (N=589). Pedal machines were used at least once by 7% of students (n=527). Controlled for gate count, no linear change of pedal machine use across days was found (b=-0.1 minutes, p=0.75) and the presence of the prompts did not change daily pedal time (p=0.63). Seven of eight items that assessed attitudes toward the intervention supported intervention feasibility (p<0.05). The unique non-individualized approach of retrofitting a library with pedal machines to reduce sedentary behavior seems feasible, but improvement of its effectiveness is needed. This study could inform future studies aimed at reshaping traditionally sedentary settings to improve public health. Copyright © 2014 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.

Customized Consensus Spectral Library Building for Untargeted Quantitative Metabolomics Analysis with Data Independent Acquisition Mass Spectrometry and MetaboDIA Workflow.

PubMed

Chen, Gengbo; Walmsley, Scott; Cheung, Gemmy C M; Chen, Liyan; Cheng, Ching-Yu; Beuerman, Roger W; Wong, Tien Yin; Zhou, Lei; Choi, Hyungwon

2017-05-02

Data independent acquisition-mass spectrometry (DIA-MS) coupled with liquid chromatography is a promising approach for rapid, automatic sampling of MS/MS data in untargeted metabolomics. However, wide isolation windows in DIA-MS generate MS/MS spectra containing a mixed population of fragment ions together with their precursor ions. This precursor-fragment ion map in a comprehensive MS/MS spectral library is crucial for relative quantification of fragment ions uniquely representative of each precursor ion. However, existing reference libraries are not sufficient for this purpose since the fragmentation patterns of small molecules can vary in different instrument setups. Here we developed a bioinformatics workflow called MetaboDIA to build customized MS/MS spectral libraries using a user's own data dependent acquisition (DDA) data and to perform MS/MS-based quantification with DIA data, thus complementing conventional MS1-based quantification. MetaboDIA also allows users to build a spectral library directly from DIA data in studies of a large sample size. Using a marine algae data set, we show that quantification of fragment ions extracted with a customized MS/MS library can provide as reliable quantitative data as the direct quantification of precursor ions based on MS1 data. To test its applicability in complex samples, we applied MetaboDIA to a clinical serum metabolomics data set, where we built a DDA-based spectral library containing consensus spectra for 1829 compounds. We performed fragment ion quantification using DIA data using this library, yielding sensitive differential expression analysis.

Optimized auxiliary basis sets for density fitted post-Hartree-Fock calculations of lanthanide containing molecules

NASA Astrophysics Data System (ADS)

Chmela, Jiří; Harding, Michael E.

2018-06-01

Optimised auxiliary basis sets for lanthanide atoms (Ce to Lu) for four basis sets of the Karlsruhe error-balanced segmented contracted def2 - series (SVP, TZVP, TZVPP and QZVPP) are reported. These auxiliary basis sets enable the use of the resolution-of-the-identity (RI) approximation in post Hartree-Fock methods - as for example, second-order perturbation theory (MP2) and coupled cluster (CC) theory. The auxiliary basis sets are tested on an enlarged set of about a hundred molecules where the test criterion is the size of the RI error in MP2 calculations. Our tests also show that the same auxiliary basis sets can be used together with different effective core potentials. With these auxiliary basis set calculations of MP2 and CC quality can now be performed efficiently on medium-sized molecules containing lanthanides.

Public library consumer health information pilot project: results of a National Library of Medicine evaluation

PubMed Central

Wood, Fred B.; Lyon, Becky; Schell, Mary Beth; Kitendaugh, Paula; Cid, Victor H.; Siegel, Elliot R.

2000-01-01

In October 1998, the National Library of Medicine (NLM) launched a pilot project to learn about the role of public libraries in providing health information to the public and to generate information that would assist NLM and the National Network of Libraries of Medicine (NN/LM) in learning how best to work with public libraries in the future. Three regional medical libraries (RMLs), eight resource libraries, and forty-one public libraries or library systems from nine states and the District of Columbia were selected for participation. The pilot project included an evaluation component that was carried out in parallel with project implementation. The evaluation ran through September 1999. The results of the evaluation indicated that participating public librarians were enthusiastic about the training and information materials provided as part of the project and that many public libraries used the materials and conducted their own outreach to local communities and groups. Most libraries applied the modest funds to purchase additional Internet-accessible computers and/or upgrade their health-reference materials. However, few of the participating public libraries had health information centers (although health information was perceived as a top-ten or top-five topic of interest to patrons). Also, the project generated only minimal usage of NLM's consumer health database, known as MEDLINEplus, from the premises of the monitored libraries (patron usage from home or office locations was not tracked). The evaluation results suggested a balanced follow-up by NLM and the NN/LM, with a few carefully selected national activities, complemented by a package of targeted activities that, as of January 2000, are being planned, developed, or implemented. The results also highlighted the importance of building an evaluation component into projects like this one from the outset, to assure that objectives were met and that evaluative information was available on a timely basis, as was the case here. PMID:11055298

Public library consumer health information pilot project: results of a National Library of Medicine evaluation.

PubMed

Wood, F B; Lyon, B; Schell, M B; Kitendaugh, P; Cid, V H; Siegel, E R

2000-10-01

In October 1998, the National Library of Medicine (NLM) launched a pilot project to learn about the role of public libraries in providing health information to the public and to generate information that would assist NLM and the National Network of Libraries of Medicine (NN/LM) in learning how best to work with public libraries in the future. Three regional medical libraries (RMLs), eight resource libraries, and forty-one public libraries or library systems from nine states and the District of Columbia were selected for participation. The pilot project included an evaluation component that was carried out in parallel with project implementation. The evaluation ran through September 1999. The results of the evaluation indicated that participating public librarians were enthusiastic about the training and information materials provided as part of the project and that many public libraries used the materials and conducted their own outreach to local communities and groups. Most libraries applied the modest funds to purchase additional Internet-accessible computers and/or upgrade their health-reference materials. However, few of the participating public libraries had health information centers (although health information was perceived as a top-ten or top-five topic of interest to patrons). Also, the project generated only minimal usage of NLM's consumer health database, known as MEDLINEplus, from the premises of the monitored libraries (patron usage from home or office locations was not tracked). The evaluation results suggested a balanced follow-up by NLM and the NN/LM, with a few carefully selected national activities, complemented by a package of targeted activities that, as of January 2000, are being planned, developed, or implemented. The results also highlighted the importance of building an evaluation component into projects like this one from the outset, to assure that objectives were met and that evaluative information was available on a timely basis, as was the case here.

Planning a new library in an age of transition: the Washington University School of Medicine Library and Biomedical Communications Center.

PubMed Central

Crawford, S; Halbrook, B

1990-01-01

In an era of great technological and socioeconomic changes, the Washington University School of Medicine conceptualized and built its first Library and Biomedical Communications Center in seventy-eight years. The planning process, evolution of the electronic library, and translation of functions into operating spaces are discussed. Since 1983, when the project was approved, a whole range of information technologies and services have emerged. The authors consider the kind of library that would operate in a setting where people can do their own searches, order data and materials through an electronic network, analyze and manage information, and use software to create their own publications. Images PMID:2393757

A DNA Barcode Library for Korean Chironomidae (Insecta: Diptera) and Indexes for Defining Barcode Gap

PubMed Central

Kim, Sungmin; Song, Kyo-Hong; Ree, Han-Il; Kim, Won

2012-01-01

Non-biting midges (Diptera: Chironomidae) are a diverse population that commonly causes respiratory allergies in humans. Chironomid larvae can be used to indicate freshwater pollution, but accurate identification on the basis of morphological characteristics is difficult. In this study, we constructed a mitochondrial cytochrome c oxidase subunit I (COI)-based DNA barcode library for Korean chironomids. This library consists of 211 specimens from 49 species, including adults and unidentified larvae. The interspecies and intraspecies COI sequence variations were analyzed. Sophisticated indexes were developed in order to properly evaluate indistinct barcode gaps that are created by insufficient sampling on both the interspecies and intraspecies levels and by variable mutation rates across taxa. In a variety of insect datasets, these indexes were useful for re-evaluating large barcode datasets and for defining COI barcode gaps. The COI-based DNA barcode library will provide a rapid and reliable tool for the molecular identification of Korean chironomid species. Furthermore, this reverse-taxonomic approach will be improved by the continuous addition of other speceis’ sequences to the library. PMID:22138764

FilTer BaSe: A web accessible chemical database for small compound libraries.

PubMed

Kolte, Baban S; Londhe, Sanjay R; Solanki, Bhushan R; Gacche, Rajesh N; Meshram, Rohan J

2018-03-01

Finding novel chemical agents for targeting disease associated drug targets often requires screening of large number of new chemical libraries. In silico methods are generally implemented at initial stages for virtual screening. Filtering of such compound libraries on physicochemical and substructure ground is done to ensure elimination of compounds with undesired chemical properties. Filtering procedure, is redundant, time consuming and requires efficient bioinformatics/computer manpower along with high end software involving huge capital investment that forms a major obstacle in drug discovery projects in academic setup. We present an open source resource, FilTer BaSe- a chemoinformatics platform (http://bioinfo.net.in/filterbase/) that host fully filtered, ready to use compound libraries with workable size. The resource also hosts a database that enables efficient searching the chemical space of around 348,000 compounds on the basis of physicochemical and substructure properties. Ready to use compound libraries and database presented here is expected to aid a helping hand for new drug developers and medicinal chemists. Copyright © 2017 Elsevier Inc. All rights reserved.

Toward automated biochemotype annotation for large compound libraries.

PubMed

Chen, Xian; Liang, Yizeng; Xu, Jun

2006-08-01

Combinatorial chemistry allows scientists to probe large synthetically accessible chemical space. However, identifying the sub-space which is selectively associated with an interested biological target, is crucial to drug discovery and life sciences. This paper describes a process to automatically annotate biochemotypes of compounds in a library and thus to identify bioactivity related chemotypes (biochemotypes) from a large library of compounds. The process consists of two steps: (1) predicting all possible bioactivities for each compound in a library, and (2) deriving possible biochemotypes based on predictions. The Prediction of Activity Spectra for Substances program (PASS) was used in the first step. In second step, structural similarity and scaffold-hopping technologies are employed. These technologies are used to derive biochemotypes from bioactivity predictions and the corresponding annotated biochemotypes from MDL Drug Data Report (MDDR) database. About a one million (982,889) commercially available compound library (CACL) has been tested using this process. This paper demonstrates the feasibility of automatically annotating biochemotypes for large libraries of compounds. Nevertheless, some issues need to be considered in order to improve the process. First, the prediction accuracy of PASS program has no significant correlation with the number of compounds in a training set. Larger training sets do not necessarily increase the maximal error of prediction (MEP), nor do they increase the hit structural diversity. Smaller training sets do not necessarily decrease MEP, nor do they decrease the hit structural diversity. Second, the success of systematic bioactivity prediction relies on modeling, training data, and the definition of bioactivities (biochemotype ontology). Unfortunately, the biochemotype ontology was not well developed in the PASS program. Consequently, "ill-defined" bioactivities can reduce the quality of predictions. This paper suggests the ways in which the systematic bioactivities prediction program should be improved.

Ab Initio Density Fitting: Accuracy Assessment of Auxiliary Basis Sets from Cholesky Decompositions.

PubMed

Boström, Jonas; Aquilante, Francesco; Pedersen, Thomas Bondo; Lindh, Roland

2009-06-09

The accuracy of auxiliary basis sets derived by Cholesky decompositions of the electron repulsion integrals is assessed in a series of benchmarks on total ground state energies and dipole moments of a large test set of molecules. The test set includes molecules composed of atoms from the first three rows of the periodic table as well as transition metals. The accuracy of the auxiliary basis sets are tested for the 6-31G**, correlation consistent, and atomic natural orbital basis sets at the Hartree-Fock, density functional theory, and second-order Møller-Plesset levels of theory. By decreasing the decomposition threshold, a hierarchy of auxiliary basis sets is obtained with accuracies ranging from that of standard auxiliary basis sets to that of conventional integral treatments.

Mass Spectral Library Quality Assurance by Inter-Library Comparison

NASA Astrophysics Data System (ADS)

Wallace, William E.; Ji, Weihua; Tchekhovskoi, Dmitrii V.; Phinney, Karen W.; Stein, Stephen E.

2017-04-01

A method to discover and correct errors in mass spectral libraries is described. Comparing across a set of highly curated reference libraries compounds that have the same chemical structure quickly identifies entries that are outliers. In cases where three or more entries for the same compound are compared, the outlier as determined by visual inspection was almost always found to contain the error. These errors were either in the spectrum itself or in the chemical descriptors that accompanied it. The method is demonstrated on finding errors in compounds of forensic interest in the NIST/EPA/NIH Mass Spectral Library. The target list of compounds checked was the Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG) mass spectral library. Some examples of errors found are described. A checklist of errors that curators should look for when performing inter-library comparisons is provided.

Mass Spectral Library Quality Assurance by Inter-Library Comparison

PubMed Central

Wallace, W.E.; Ji, W.; Tchekhovskoi, D.V.; Phinney, K.W.; Stein, S.E.

2017-01-01

A method to discover and correct errors in mass spectral libraries is described. Comparing across a set of highly curated reference libraries compounds that have the same chemical structure quickly identifies entries that are outliers. In cases where three or more entries for the same compound are compared the outlier as determined by visual inspection was almost always found to contain the error. These errors were either in the spectrum itself or in the chemical descriptors that accompanied it. The method is demonstrated on finding errors in compounds of forensic interest in the NIST/EPA/NIH Mass Spectral Library. The target list of compounds checked was the Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG) mass spectral library. Some examples of errors found are described. A checklist of errors that curators should look for when performing inter-library comparisons is provided. PMID:28127680

Trend spotting--whither health science librarianship?

PubMed

Murphy, Jeannette

2011-12-01

This feature surveys 20th-century trends in health sciences librarianship. It sets the scene for a series of features looking at 21st-century trends in various countries and regions. Whilst the mission of the health science library remains constant, librarians must find ways of adjusting their role and the services they provide to take account of changes in the external environment. © 2011 The authors. Health Information and Libraries Journal © 2011 Health Libraries Group.

Specifications of a Mechanized Center for Information Services for a Public Library Reference Center. Final Report. Part 1, Preliminary Specification: Mechanized Information Services in Public Library Reference Centers.

ERIC Educational Resources Information Center

California Univ., Los Angeles. Inst. of Library Research.

This document presents preliminary specifications for a library-based Center for Information Services (CIS). Four sets of issues are covered: (1) data base inventory, providing a listing of magnetic tape data bases now available from national sources or soon to be so; (2) administrative issues, including the organization of the CIS within the…

pyGIMLi: An open-source library for modelling and inversion in geophysics

NASA Astrophysics Data System (ADS)

Rücker, Carsten; Günther, Thomas; Wagner, Florian M.

2017-12-01

Many tasks in applied geosciences cannot be solved by single measurements, but require the integration of geophysical, geotechnical and hydrological methods. Numerical simulation techniques are essential both for planning and interpretation, as well as for the process understanding of modern geophysical methods. These trends encourage open, simple, and modern software architectures aiming at a uniform interface for interdisciplinary and flexible modelling and inversion approaches. We present pyGIMLi (Python Library for Inversion and Modelling in Geophysics), an open-source framework that provides tools for modelling and inversion of various geophysical but also hydrological methods. The modelling component supplies discretization management and the numerical basis for finite-element and finite-volume solvers in 1D, 2D and 3D on arbitrarily structured meshes. The generalized inversion framework solves the minimization problem with a Gauss-Newton algorithm for any physical forward operator and provides opportunities for uncertainty and resolution analyses. More general requirements, such as flexible regularization strategies, time-lapse processing and different sorts of coupling individual methods are provided independently of the actual methods used. The usage of pyGIMLi is first demonstrated by solving the steady-state heat equation, followed by a demonstration of more complex capabilities for the combination of different geophysical data sets. A fully coupled hydrogeophysical inversion of electrical resistivity tomography (ERT) data of a simulated tracer experiment is presented that allows to directly reconstruct the underlying hydraulic conductivity distribution of the aquifer. Another example demonstrates the improvement of jointly inverting ERT and ultrasonic data with respect to saturation by a new approach that incorporates petrophysical relations in the inversion. Potential applications of the presented framework are manifold and include time-lapse, constrained, joint, and coupled inversions of various geophysical and hydrological data sets.

Evaluation of the Mycobacterium smegmatis and BCG models for the discovery of Mycobacterium tuberculosis inhibitors.

PubMed

Altaf, Mudassar; Miller, Christopher H; Bellows, David S; O'Toole, Ronan

2010-11-01

The objective of this study was to measure the efficacy of Mycobacterium smegmatis as a surrogate in vitro model for the detection of compounds which are inhibitory to the growth of Mycobacterium tuberculosis. A chemical screen of the LOPAC library for anti-mycobacterial compounds was performed using M. smegmatis. Parallel screens were conducted with another tuberculosis model, Mycobacterium bovis BCG, and with M. tuberculosis under identical growth conditions and the inhibitors detected across the three species were compared. 50% of compounds that were detected as active against M. tuberculosis were not detected using M. smegmatis compared to 21% of compounds using M. bovis BCG. To examine whether these findings were unique to LOPAC, screens were performed with the NIH Diversity Set and Spectrum Collection. An even higher proportion of M. tuberculosis inhibitors were not detected from the NIH Diversity Set and Spectrum Collection using M. smegmatis compared to M. bovis BCG. These data reveal that a significant proportion of M. tuberculosis inhibitors are missed in library screening with M. smegmatis. The basis of the variation in the inhibitory profiles of M. smegmatis and M. tuberculosis has yet to be fully determined, however, our genomic comparisons indicate that approximately 30% of M. tuberculosis proteins lack conserved orthologues in M. smegmatis compared to 3% being absent in M. bovis BCG. In conclusion, although M. smegmatis offers some technical benefits such as a shorter generation time and negligible risk to laboratory workers, it is significantly less effective in the detection of anti-M. tuberculosis compounds relative to M. bovis BCG. This limitation needs to be taken into consideration when selecting an in vitro screening model for tuberculosis drug discovery. Copyright © 2010 Elsevier Ltd. All rights reserved.

Probing the mutational interplay between primary and promiscuous protein functions: a computational-experimental approach.

PubMed

Garcia-Seisdedos, Hector; Ibarra-Molero, Beatriz; Sanchez-Ruiz, Jose M

2012-01-01

Protein promiscuity is of considerable interest due its role in adaptive metabolic plasticity, its fundamental connection with molecular evolution and also because of its biotechnological applications. Current views on the relation between primary and promiscuous protein activities stem largely from laboratory evolution experiments aimed at increasing promiscuous activity levels. Here, on the other hand, we attempt to assess the main features of the simultaneous modulation of the primary and promiscuous functions during the course of natural evolution. The computational/experimental approach we propose for this task involves the following steps: a function-targeted, statistical coupling analysis of evolutionary data is used to determine a set of positions likely linked to the recruitment of a promiscuous activity for a new function; a combinatorial library of mutations on this set of positions is prepared and screened for both, the primary and the promiscuous activities; a partial-least-squares reconstruction of the full combinatorial space is carried out; finally, an approximation to the Pareto set of variants with optimal primary/promiscuous activities is derived. Application of the approach to the emergence of folding catalysis in thioredoxin scaffolds reveals an unanticipated scenario: diverse patterns of primary/promiscuous activity modulation are possible, including a moderate (but likely significant in a biological context) simultaneous enhancement of both activities. We show that this scenario can be most simply explained on the basis of the conformational diversity hypothesis, although alternative interpretations cannot be ruled out. Overall, the results reported may help clarify the mechanisms of the evolution of new functions. From a different viewpoint, the partial-least-squares-reconstruction/Pareto-set-prediction approach we have introduced provides the computational basis for an efficient directed-evolution protocol aimed at the simultaneous enhancement of several protein features and should therefore open new possibilities in the engineering of multi-functional enzymes.

Probing the Mutational Interplay between Primary and Promiscuous Protein Functions: A Computational-Experimental Approach

PubMed Central

Garcia-Seisdedos, Hector; Ibarra-Molero, Beatriz; Sanchez-Ruiz, Jose M.

2012-01-01

Protein promiscuity is of considerable interest due its role in adaptive metabolic plasticity, its fundamental connection with molecular evolution and also because of its biotechnological applications. Current views on the relation between primary and promiscuous protein activities stem largely from laboratory evolution experiments aimed at increasing promiscuous activity levels. Here, on the other hand, we attempt to assess the main features of the simultaneous modulation of the primary and promiscuous functions during the course of natural evolution. The computational/experimental approach we propose for this task involves the following steps: a function-targeted, statistical coupling analysis of evolutionary data is used to determine a set of positions likely linked to the recruitment of a promiscuous activity for a new function; a combinatorial library of mutations on this set of positions is prepared and screened for both, the primary and the promiscuous activities; a partial-least-squares reconstruction of the full combinatorial space is carried out; finally, an approximation to the Pareto set of variants with optimal primary/promiscuous activities is derived. Application of the approach to the emergence of folding catalysis in thioredoxin scaffolds reveals an unanticipated scenario: diverse patterns of primary/promiscuous activity modulation are possible, including a moderate (but likely significant in a biological context) simultaneous enhancement of both activities. We show that this scenario can be most simply explained on the basis of the conformational diversity hypothesis, although alternative interpretations cannot be ruled out. Overall, the results reported may help clarify the mechanisms of the evolution of new functions. From a different viewpoint, the partial-least-squares-reconstruction/Pareto-set-prediction approach we have introduced provides the computational basis for an efficient directed-evolution protocol aimed at the simultaneous enhancement of several protein features and should therefore open new possibilities in the engineering of multi-functional enzymes. PMID:22719242

Library Bulletin [International Planned Parenthood Federation, May 1976].

ERIC Educational Resources Information Center

International Planned Parenthood Federation, London (England).

This loose-leaf collection includes a brief discussion of usage procedures for International Planned Parenthood Federation (IPPF) libraries. A set of annotated bibliographies follows, including descriptions of documents on the following topics: family planning and biomedical science, social sciences related to family planning, education and…

Strategies for Change: Part I.

ERIC Educational Resources Information Center

Atkinson, Hugh C.

1984-01-01

Focusing on notion of change as integrated into personal and library settings, this essay discusses routines versus change, redistribution of resources, effects of economic recession, technological changes in information transfer media (papyrus and clay tablets, video disks, fiber optics, microcomputers, databases), and changes in library patrons'…

Literacies, Narratives, and Adult Learning in Libraries

ERIC Educational Resources Information Center

Elmborg, Jim

2010-01-01

Learners within academic library settings use information resources toward specific ends--learner-constructed research and writing projects that offer new perspectives on particular topics. Such projects may take the form of individual research papers and/or class presentations, literature reviews, theses, e-portfolios, web pages, or…

Setting Up a Special Collection on Water Pollution in a University Library

ERIC Educational Resources Information Center

Friedlander, Janet

1974-01-01

The establishment of a special collection within the university library, the complexities of identifying and collecting reports in the environmental area, locating agencies concerned with water pollution, and recording the location of other local collections of data are described. (Author)

Scaling Irregular Applications through Data Aggregation and Software Multithreading

DOE Office of Scientific and Technical Information (OSTI.GOV)

Morari, Alessandro; Tumeo, Antonino; Chavarría-Miranda, Daniel

Bioinformatics, data analytics, semantic databases, knowledge discovery are emerging high performance application areas that exploit dynamic, linked data structures such as graphs, unbalanced trees or unstructured grids. These data structures usually are very large, requiring significantly more memory than available on single shared memory systems. Additionally, these data structures are difficult to partition on distributed memory systems. They also present poor spatial and temporal locality, thus generating unpredictable memory and network accesses. The Partitioned Global Address Space (PGAS) programming model seems suitable for these applications, because it allows using a shared memory abstraction across distributed-memory clusters. However, current PGAS languagesmore » and libraries are built to target regular remote data accesses and block transfers. Furthermore, they usually rely on the Single Program Multiple Data (SPMD) parallel control model, which is not well suited to the fine grained, dynamic and unbalanced parallelism of irregular applications. In this paper we present {\\bf GMT} (Global Memory and Threading library), a custom runtime library that enables efficient execution of irregular applications on commodity clusters. GMT integrates a PGAS data substrate with simple fork/join parallelism and provides automatic load balancing on a per node basis. It implements multi-level aggregation and lightweight multithreading to maximize memory and network bandwidth with fine-grained data accesses and tolerate long data access latencies. A key innovation in the GMT runtime is its thread specialization (workers, helpers and communication threads) that realize the overall functionality. We compare our approach with other PGAS models, such as UPC running using GASNet, and hand-optimized MPI code on a set of typical large-scale irregular applications, demonstrating speedups of an order of magnitude.« less

Nitrate-induced genes in tomato roots. Array analysis reveals novel genes that may play a role in nitrogen nutrition.

PubMed

Wang, Y H; Garvin, D F; Kochian, L V

2001-09-01

A subtractive tomato (Lycopersicon esculentum) root cDNA library enriched in genes up-regulated by changes in plant mineral status was screened with labeled mRNA from roots of both nitrate-induced and mineral nutrient-deficient (-nitrogen [N], -phosphorus, -potassium [K], -sulfur, -magnesium, -calcium, -iron, -zinc, and -copper) tomato plants. A subset of cDNAs was selected from this library based on mineral nutrient-related changes in expression. Additional cDNAs were selected from a second mineral-deficient tomato root library based on sequence homology to known genes. These selection processes yielded a set of 1,280 mineral nutrition-related cDNAs that were arrayed on nylon membranes for further analysis. These high-density arrays were hybridized with mRNA from tomato plants exposed to nitrate at different time points after N was withheld for 48 h, for plants that were grown on nitrate/ammonium for 5 weeks prior to the withholding of N. One hundred-fifteen genes were found to be up-regulated by nitrate resupply. Among these genes were several previously identified as nitrate responsive, including nitrate transporters, nitrate and nitrite reductase, and metabolic enzymes such as transaldolase, transketolase, malate dehydrogenase, asparagine synthetase, and histidine decarboxylase. We also identified 14 novel nitrate-inducible genes, including: (a) water channels, (b) root phosphate and K(+) transporters, (c) genes potentially involved in transcriptional regulation, (d) stress response genes, and (e) ribosomal protein genes. In addition, both families of nitrate transporters were also found to be inducible by phosphate, K, and iron deficiencies. The identification of these novel nitrate-inducible genes is providing avenues of research that will yield new insights into the molecular basis of plant N nutrition, as well as possible networking between the regulation of N, phosphorus, and K nutrition.

The Computerized Reference Department: Buying the Future.

ERIC Educational Resources Information Center

Kriz, Harry M.; Kok, Victoria T.

1985-01-01

Basis for systematic computerization of academic research library's reference, collection development, and collection management functions emphasizes productivity enhancement for librarians and support staff. Use of microcomputer and university's mainframe computer to develop applications of database management systems, electronic spreadsheets,…

S2PLOT: Three-dimensional (3D) Plotting Library

NASA Astrophysics Data System (ADS)

Barnes, D. G.; Fluke, C. J.; Bourke, P. D.; Parry, O. T.

2011-03-01

We present a new, three-dimensional (3D) plotting library with advanced features, and support for standard and enhanced display devices. The library - S2PLOT - is written in C and can be used by C, C++ and FORTRAN programs on GNU/Linux and Apple/OSX systems. S2PLOT draws objects in a 3D (x,y,z) Cartesian space and the user interactively controls how this space is rendered at run time. With a PGPLOT inspired interface, S2PLOT provides astronomers with elegant techniques for displaying and exploring 3D data sets directly from their program code, and the potential to use stereoscopic and dome display devices. The S2PLOT architecture supports dynamic geometry and can be used to plot time-evolving data sets, such as might be produced by simulation codes. In this paper, we introduce S2PLOT to the astronomical community, describe its potential applications, and present some example uses of the library.

An Advanced, Three-Dimensional Plotting Library for Astronomy

NASA Astrophysics Data System (ADS)

Barnes, David G.; Fluke, Christopher J.; Bourke, Paul D.; Parry, Owen T.

2006-07-01

We present a new, three-dimensional (3D) plotting library with advanced features, and support for standard and enhanced display devices. The library - s2plot - is written in c and can be used by c, c++, and fortran programs on GNU/Linux and Apple/OSX systems. s2plot draws objects in a 3D (x,y,z) Cartesian space and the user interactively controls how this space is rendered at run time. With a pgplot-inspired interface, s2plot provides astronomers with elegant techniques for displaying and exploring 3D data sets directly from their program code, and the potential to use stereoscopic and dome display devices. The s2plot architecture supports dynamic geometry and can be used to plot time-evolving data sets, such as might be produced by simulation codes. In this paper, we introduce s2plot to the astronomical community, describe its potential applications, and present some example uses of the library.

Expanding services in a shrinking economy: desktop document delivery in a dental school library

PubMed Central

Gushrowski, Barbara A

2011-01-01

Question: How can library staff develop and promote a document delivery service and then expand the service to a wide audience? Setting: The setting is the library at the Indiana University School of Dentistry (IUSD), Indianapolis. Method: A faculty survey and a citation analysis were conducted to determine potential use of the service. Volume of interlibrary loan transactions and staff and equipment capacity were also studied. Main results: IUSD Library staff created a desktop delivery service (DDSXpress) for faculty and then expanded the service to practicing dental professionals and graduate students. The number of faculty using DDSXpress remains consistent. The number of practicing dental professionals using the service is low. Graduate students have been quick to adopt the service. Conclusion: Through careful analysis of capacity and need for the service, staff successfully expanded document delivery service without incurring additional costs. Use of DDSXpress is continually monitored, and opportunities to market the service to practicing dental professionals are being investigated. PMID:21753911

Natural product-like virtual libraries: recursive atom-based enumeration.

PubMed

Yu, Melvin J

2011-03-28

A new molecular enumerator is described that allows chemically and architecturally diverse sets of natural product-like and drug-like structures to be generated from a core structure as simple as a single carbon atom or as complex as a polycyclic ring system. Integrated with a rudimentary machine-learning algorithm, the enumerator has the ability to assemble biased virtual libraries enriched in compounds predicted to meet target criteria. The ability to dynamically generate relatively small focused libraries in a recursive manner could reduce the computational time and infrastructure necessary to construct and manage extremely large static libraries. Depending on enumeration conditions, natural product-like structures can be produced with a wide range of heterocyclic and alicyclic ring assemblies. Because natural products represent a proven source of validated structures for identifying and designing new drug candidates, mimicking the structural and topological diversity found in nature with a dynamic set of virtual natural product-like compounds may facilitate the creation of new ideas for novel, biologically relevant lead structures in areas of uncharted chemical space.

Use of Massive Parallel Computing Libraries in the Context of Global Gravity Field Determination from Satellite Data

NASA Astrophysics Data System (ADS)

Brockmann, J. M.; Schuh, W.-D.

2011-07-01

The estimation of the global Earth's gravity field parametrized as a finite spherical harmonic series is computationally demanding. The computational effort depends on the one hand on the maximal resolution of the spherical harmonic expansion (i.e. the number of parameters to be estimated) and on the other hand on the number of observations (which are several millions for e.g. observations from the GOCE satellite missions). To circumvent these restrictions, a massive parallel software based on high-performance computing (HPC) libraries as ScaLAPACK, PBLAS and BLACS was designed in the context of GOCE HPF WP6000 and the GOCO consortium. A prerequisite for the use of these libraries is that all matrices are block-cyclic distributed on a processor grid comprised by a large number of (distributed memory) computers. Using this set of standard HPC libraries has the benefit that once the matrices are distributed across the computer cluster, a huge set of efficient and highly scalable linear algebra operations can be used.

Educational technologies in health sciences libraries: teaching technology skills.

PubMed

Hurst, Emily J

2014-01-01

As technology rapidly changes, libraries remain go-to points for education and technology skill development. In academic health sciences libraries, trends suggest librarians provide more training on technology topics than ever before. While education and training have always been roles for librarians, providing technology training on new mobile devices and emerging systems requires class creation and training capabilities that are new to many librarians. To appeal to their users, many health sciences librarians are interested in developing technology-based classes. This column explores the question: what skills are necessary for developing and teaching technology in an academic health sciences library setting?

Tips and Tricks of Incorporating Industry Standards into a Library Collection

DOE Office of Scientific and Technical Information (OSTI.GOV)

Abbott, Jennifer; Sandberg, Tami

Professional literature on the incorporation of industry standards into a library collection is somewhat limited. The objective of this presentation is to discuss the intricate details of acquiring, managing, and delivering electronic industry standards to library patrons in a seamless manner. Lessons learned regarding vendor selection and license agreements will also be discussed. Results from a survey administer at the National Renewable Energy Laboratory will be used to analyze how collection policies can properly be developed to incorporate industry standards into a library setting. The key points of acquisition decisions, avoidance of liability issues, and cost will be addressed.

Adapting an embedded model of librarianship, college by college.

PubMed

Blake, Lindsay; Mears, Kim; Davies, Kathy; Ballance, Darra; Shipman, Peter; Connolly-Brown, Maryska; Gaines, Julie K

2014-01-01

Librarians are increasingly moving out of the library and into the wider university setting as patrons spend more time seeking information online and less time visiting the library. The move to embed librarians in colleges, departments, or customer groups has been going on for some time but has recently received more attention as libraries work to find new ways to reach patrons that no longer need to come to the physical library. Few universities have attempted to embed all their librarians. This case study describes how one group of health sciences librarians dispersed its professional staff throughout its campuses and medical centers.

Educational Technologies in Health Science Libraries: Teaching Technology Skills

PubMed Central

Hurst, Emily J.

2014-01-01

As technology rapidly changes, libraries remain go-to points for education and technology skill development. In academic health sciences libraries, trends suggest librarians provide more training on technology topics than ever before. While education and training have always been roles for librarians, providing technology training on new mobile devices and emerging systems requires class creation and training capabilities that are new to many. To appeal to their users, many health sciences librarians are interested in developing technology-based classes. This column explores the question: what skills are necessary for developing and teaching technology in an academic health sciences library setting? PMID:24528269

Case study: the Health SmartLibrary* experiences in web personalization and customization at the Galter Health Sciences Library, Northwestern University

PubMed Central

Shedlock, James; Frisque, Michelle; Hunt, Steve; Walton, Linda; Handler, Jonathan; Gillam, Michael

2010-01-01

Question: How can the user's access to health information, especially full-text articles, be improved? The solution is building and evaluating the Health SmartLibrary (HSL). Setting: The setting is the Galter Health Sciences Library, Feinberg School of Medicine, Northwestern University. Method: The HSL was built on web-based personalization and customization tools: My E-Resources, Stay Current, Quick Search, and File Cabinet. Personalization and customization data were tracked to show user activity with these value-added, online services. Main Results: Registration data indicated that users were receptive to personalized resource selection and that the automated application of specialty-based, personalized HSLs was more frequently adopted than manual customization by users. Those who did customize customized My E-Resources and Stay Current more often than Quick Search and File Cabinet. Most of those who customized did so only once. Conclusion: Users did not always take advantage of the services designed to aid their library research experiences. When personalization is available at registration, users readily accepted it. Customization tools were used less frequently; however, more research is needed to determine why this was the case. PMID:20428276

Scaling up the 454 Titanium Library Construction and Pooling of Barcoded Libraries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Phung, Wilson; Hack, Christopher; Shapiro, Harris

2009-03-23

We have been developing a high throughput 454 library construction process at the Joint Genome Institute to meet the needs of de novo sequencing a large number of microbial and eukaryote genomes, EST, and metagenome projects. We have been focusing efforts in three areas: (1) modifying the current process to allow the construction of 454 standard libraries on a 96-well format; (2) developing a robotic platform to perform the 454 library construction; and (3) designing molecular barcodes to allow pooling and sorting of many different samples. In the development of a high throughput process to scale up the number ofmore » libraries by adapting the process to a 96-well plate format, the key process change involves the replacement of gel electrophoresis for size selection with Solid Phase Reversible Immobilization (SPRI) beads. Although the standard deviation of the insert sizes increases, the overall quality sequence and distribution of the reads in the genome has not changed. The manual process of constructing 454 shotgun libraries on 96-well plates is a time-consuming, labor-intensive, and ergonomically hazardous process; we have been experimenting to program a BioMek robot to perform the library construction. This will not only enable library construction to be completed in a single day, but will also minimize any ergonomic risk. In addition, we have implemented a set of molecular barcodes (AKA Multiple Identifiers or MID) and a pooling process that allows us to sequence many targets simultaneously. Here we will present the testing of pooling a set of selected fosmids derived from the endomycorrhizal fungus Glomus intraradices. By combining the robotic library construction process and the use of molecular barcodes, it is now possible to sequence hundreds of fosmids that represent a minimal tiling path of this genome. Here we present the progress and the challenges of developing these scaled-up processes.« less

Using geographic information systems to identify prospective marketing areas for a special library.

PubMed

McConnaughy, Rozalynd P; Wilson, Steven P

2006-05-04

The Center for Disability Resources (CDR) Library is the largest collection of its kind in the Southeastern United States, consisting of over 5,200 books, videos/DVDs, brochures, and audiotapes covering a variety of disability-related topics, from autism to transition resources. The purpose of the library is to support the information needs of families, faculty, students, staff, and other professionals in South Carolina working with individuals with disabilities. The CDR Library is funded on a yearly basis; therefore, maintaining high usage is crucial. A variety of promotional efforts have been used to attract new patrons to the library. Anyone in South Carolina can check out materials from the library, and most of the patrons use the library remotely by requesting materials, which are then mailed to them. The goal of this project was to identify areas of low geographic usage as a means of identifying locations for future library marketing efforts. Nearly four years worth of library statistics were compiled in a spreadsheet that provided information per county on the number of checkouts, the number of renewals, and the population. Five maps were created using ArcView GIS software to create visual representations of patron checkout and renewal behavior per county. Out of the 46 counties in South Carolina, eight counties never checked out materials from the library. As expected urban areas and counties near the library's physical location have high usage totals. The visual representation of the data made identification of low usage regions easier than using a standalone database with no visual-spatial component. The low usage counties will be the focus of future Center for Disability Resources Library marketing efforts. Due to the impressive visual-spatial representations created with Geographic Information Systems, which more efficiently communicate information than stand-alone database information can, librarians may benefit from the software's use as a supplemental tool for tracking library usage and planning promotional efforts.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rossi, Tuomas P., E-mail: tuomas.rossi@alumni.aalto.fi; Sakko, Arto; Puska, Martti J.

We present an approach for generating local numerical basis sets of improving accuracy for first-principles nanoplasmonics simulations within time-dependent density functional theory. The method is demonstrated for copper, silver, and gold nanoparticles that are of experimental interest but computationally demanding due to the semi-core d-electrons that affect their plasmonic response. The basis sets are constructed by augmenting numerical atomic orbital basis sets by truncated Gaussian-type orbitals generated by the completeness-optimization scheme, which is applied to the photoabsorption spectra of homoatomic metal atom dimers. We obtain basis sets of improving accuracy up to the complete basis set limit and demonstrate thatmore » the performance of the basis sets transfers to simulations of larger nanoparticles and nanoalloys as well as to calculations with various exchange-correlation functionals. This work promotes the use of the local basis set approach of controllable accuracy in first-principles nanoplasmonics simulations and beyond.« less

Cytoscape tools for the web age: D3.js and Cytoscape.js exporters

PubMed Central

Ono, Keiichiro; Demchak, Barry; Ideker, Trey

2014-01-01

In this paper we present new data export modules for Cytoscape 3 that can generate network files for Cytoscape.js and D3.js. Cytoscape.js exporter is implemented as a core feature of Cytoscape 3, and D3.js exporter is available as a Cytoscape 3 app. These modules enable users to seamlessly export network and table data sets generated in Cytoscape to popular JavaScript library readable formats. In addition, we implemented template web applications for browser-based interactive network visualization that can be used as basis for complex data visualization applications for bioinformatics research. Example web applications created with these tools demonstrate how Cytoscape works in modern data visualization workflows built with traditional desktop tools and emerging web-based technologies. This interactivity enables researchers more flexibility than with static images, thereby greatly improving the quality of insights researchers can gain from them. PMID:25520778

Cytoscape tools for the web age: D3.js and Cytoscape.js exporters.

PubMed

Ono, Keiichiro; Demchak, Barry; Ideker, Trey

2014-01-01

In this paper we present new data export modules for Cytoscape 3 that can generate network files for Cytoscape.js and D3.js. Cytoscape.js exporter is implemented as a core feature of Cytoscape 3, and D3.js exporter is available as a Cytoscape 3 app. These modules enable users to seamlessly export network and table data sets generated in Cytoscape to popular JavaScript library readable formats. In addition, we implemented template web applications for browser-based interactive network visualization that can be used as basis for complex data visualization applications for bioinformatics research. Example web applications created with these tools demonstrate how Cytoscape works in modern data visualization workflows built with traditional desktop tools and emerging web-based technologies. This interactivity enables researchers more flexibility than with static images, thereby greatly improving the quality of insights researchers can gain from them.

Generalization of Solovev’s approach to finding equilibrium solutions for axisymmetric plasmas with flow

NASA Astrophysics Data System (ADS)

M, S. CHU; Yemin, HU; Wenfeng, GUO

2018-03-01

Solovev’s approach of finding equilibrium solutions was found to be extremely useful for generating a library of linear-superposable equilibria for the purpose of shaping studies. This set of solutions was subsequently expanded to include the vacuum solutions of Zheng, Wootton and Solano, resulting in a set of functions {SOLOVEV_ZWS} that were usually used for all toroidally symmetric plasmas, commonly recognized as being able to accommodate any desired plasma shapes (complete-shaping capability). The possibility of extending the Solovev approach to toroidal equilibria with a general plasma flow is examined theoretically. We found that the only meaningful extension is to plasmas with a pure toroidal rotation and with a constant Mach number. We also show that the simplification ansatz made to the current profiles, which was the basis of the Solovev approach, should be applied more systematically to include an internal boundary condition at the magnetic axis; resulting in a modified and more useful set {SOLOVEV_ZWSm}. Explicit expressions of functions in this set are given for equilibria with a quasi-constant current density profile, with a toroidal flow at a constant Mach number and with specific heat capacity 1. The properties of {SOLOVEV_ZWSm} are studied analytically. Numerical examples of achievable equilibria are demonstrated. Although the shaping capability of the set {SOLOVE_ZWSm} is quite extensive, it nevertheless still does not have complete shaping capability, particularly for plasmas with negative curvature points on the plasma boundary such as the doublets or indented bean shaped tokamaks.

Comfort with Computers in the Library.

ERIC Educational Resources Information Center

Agati, Joseph

2002-01-01

Sets forth a list of do's and don't's when integrating aesthetics, functionality, and technology into college library computer workstation furniture. The article discusses workstation access for both portable computer users and for staff, whose needs involve desktop computers that are possibly networked with printers and other peripherals. (GR)

Data Input for Libraries: State-of-the-Art Report.

ERIC Educational Resources Information Center

Buckland, Lawrence F.

This brief overview of new manuscript preparation methods which allow authors and editors to set their own type discusses the advantages and disadvantages of optical character recognition (OCR), microcomputers and personal computers, minicomputers, and word processors for editing and database entry. Potential library applications are also…

Genomics & Genetics | National Agricultural Library

Science.gov Websites

Skip to main content Home National Agricultural Library United States Department of Agriculture Ag agricultural and environmental settings. Deadpool proximal sensing cart docx xlsx 3x jpeg 5x pdf Data from Buytaert. NAL Home | USDA.gov | Agricultural Research Service | Plain Language | FOIA | Accessibility

Human Factors in Library Administration. Revised Edition.

ERIC Educational Resources Information Center

Barnhard, Neil

Intended for the beginning or inexperienced supervisor, this continuing education course syllabus presents basic information on the development of human relations skills, particularly in the areas of leadership, communication, conflict, and motivation. Role playing situations set in various types of medical libraries are also outlined to provide…

Collaboration Practices

ERIC Educational Resources Information Center

Brodie, Carolyn S.

2006-01-01

Collaborative practices of library media specialists and teachers as set forth in "Information Power" and implemented by the Institute for Library and Information Literacy Education (ILILE) are the focus of this article. Much has been written about collaboration in the past and much is still to be learned. "Information Power" tells everyone that…

Management Matters: Planning Goals and Time

ERIC Educational Resources Information Center

Pappas, Marjorie L.

2004-01-01

This article discusses the importance of setting and implementing goals that can help change and improve a library media program over time--goals that go beyond merely keeping the library media center running. Suggestions for developing an action plan and strategies for effective time management are also presented.

Transcending Silos, Developing Synergies: Libraries and Archives

ERIC Educational Resources Information Center

Oliver, Gillian

2010-01-01

Introduction: Very little research crosses the institutional boundaries of libraries and archives, and theres appears to be little predisposition to look for areas of common interest. However, practitioners in these settings have much to learn from each other. Purpose: This paper argues that practitioners' understanding of information management…

The Screening Compound Collection: A Key Asset for Drug Discovery.

PubMed

Boss, Christoph; Hazemann, Julien; Kimmerlin, Thierry; von Korff, Modest; Lüthi, Urs; Peter, Oliver; Sander, Thomas; Siegrist, Romain

2017-10-25

In this case study on an essential instrument of modern drug discovery, we summarize our successful efforts in the last four years toward enhancing the Actelion screening compound collection. A key organizational step was the establishment of the Compound Library Committee (CLC) in September 2013. This cross-functional team consisting of computational scientists, medicinal chemists and a biologist was endowed with a significant annual budget for regular new compound purchases. Based on an initial library analysis performed in 2013, the CLC developed a New Library Strategy. The established continuous library turn-over mode, and the screening library size of 300'000 compounds were maintained, while the structural library quality was increased. This was achieved by shifting the selection criteria from 'druglike' to 'leadlike' structures, enriching for non-flat structures, aiming for compound novelty, and increasing the ratio of higher cost 'Premium Compounds'. Novel chemical space was gained by adding natural compounds, macrocycles, designed and focused libraries to the collection, and through mutual exchanges of proprietary compounds with agrochemical companies. A comparative analysis in 2016 provided evidence for the positive impact of these measures. Screening the improved library has provided several highly promising hits, including a macrocyclic compound, that are currently followed up in different Hit-to-Lead and Lead Optimization programs. It is important to state that the goal of the CLC was not to achieve higher HTS hit rates, but to increase the chances of identified hits to serve as the basis of successful early drug discovery programs. The experience gathered so far legitimates the New Library Strategy.

Biotechnology awareness study, Part 1: Where scientists get their information.

PubMed Central

Grefsheim, S; Franklin, J; Cunningham, D

1991-01-01

A model study, funded by the National Library of Medicine (NLM) and conducted by the Southeastern/Atlantic Regional Medical Library (RML) and the University of Maryland Health Sciences Library, attempted to assess the information needs of researchers in the developing field of biotechnology and to determine the resources available to meet those needs in major academic health sciences centers. Nine medical schools in RML Region 2 were selected to participate in a biotechnology awareness study. A survey was conducted of the nine medical school libraries to assess their support of biotechnology research. To identify the information needs of scientists engaged in biotechnology-related research at the schools, a written survey was sent to the deans of the nine institutions and selected scientists they had identified. This was followed by individual, in-depth interviews with both the deans and scientists surveyed. In general, scientists obtained information from three major sources: their own experiments, personal communication with other scientists, and textual material (print or electronic). For textual information, most study participants relied on personal journal subscriptions. Tangential journals were scanned in the department's library. Only a few of these scientists came to the health sciences library on a regular basis. Further, the study found that personal computers have had a major impact on how biotechnologists get and use information. Implications of these findings for libraries and librarians are discussed. PMID:1998818

[Construction of human phage antibody library and screening for human monoclonal antibodies of amylin].

PubMed

Gong, Qian; Li, Chang-ying; Chang, Ji-wu; Zhu, Tie-hong

2012-06-01

To screen monoclonal antibodies to amylin from a constructed human phage antibody library and identify their antigenic specificity and combining activities. The heavy chain Fd fragment and light chain of human immunoglobulin genes were amplified from peripheral blood lymphocytes of healthy donors using RT-PCR, and then inserted into phagemid pComb3XSS to generate a human phage antibody library. The insertion of light chain or heavy chain Fd genes were identified by PCR after the digestion of Sac I, Xba I, Xho Iand Spe I. One of positive clones was analyzed by DNA sequencing. The specific anti-amylin clones were screened from antibody library against human amylin antigens and then the positive clones were determined by Phage-ELISA analysis. A Fab phage antibody library with 0.8×10(8); members was constructed with the efficacy of about 70%. DNA sequence analysis indicated V(H); gene belonged to V(H);3 gene family and V(λ); gene belonged to the V(λ); gene family. Using human amylin as panning antigen, specific anti-amylin Fab antibodies were enriched by screening the library for three times. Phage-ELISA assay showed the positive clones had very good specificity to amylin antigen. The successful construction of a phage antibody library and the identification of anti-amylin Fab antibodies provide a basis for further study and preparation of human anti-amylin antibodies.

Library roles in disaster response: an oral history project by the National Library of Medicine*†

PubMed Central

Featherstone, Robin M.; Lyon, Becky J.; Ruffin, Angela B.

2008-01-01

Objectives: To develop a knowledgebase of stories illustrating the variety of roles that librarians can assume in emergency and disaster planning, preparedness, response, and recovery, the National Library of Medicine conducted an oral history project during the summer of 2007. The history aimed to describe clearly and compellingly the activities—both expected and unusual—that librarians performed during and in the aftermath of the disasters. While various types of libraries were included in interviews, the overall focus of the project was on elucidating roles for medical libraries. Methods: Using four broad questions as the basis for telephone and email interviews, the investigators recorded the stories of twenty-three North American librarians who responded to bombings and other acts of terrorism, earthquakes, epidemics, fires, floods, hurricanes, and tornados. Results: Through the process of conducting the oral history, an understanding of multiple roles for libraries in disaster response emerged. The roles fit into eight categories: institutional supporters, collection managers, information disseminators, internal planners, community supporters, government partners, educators and trainers, and information community builders. Conclusions: Librarians—particularly health sciences librarians—made significant contributions to preparedness and recovery activities surrounding recent disasters. Lessons learned from the oral history project increased understanding of and underscored the value of collaborative relationships between libraries and local, state, and federal disaster management agencies and organizations. PMID:18974811

Designing a diverse high-quality library for crystallography-based FBDD screening.

PubMed

Tounge, Brett A; Parker, Michael H

2011-01-01

A well-chosen set of fragments is able to cover a large chemical space using a small number of compounds. The actual size and makeup of the fragment set is dependent on the screening method since each technique has its own practical limits in terms of the number of compounds that can be screened and requirements for compound solubility. In this chapter, an overview of the general requirements for a fragment library is presented for different screening platforms. In the case of the FBDD work at Johnson & Johnson Pharmaceutical Research and Development, L.L.C., our main screening technology is X-ray crystallography. Since every soaked protein crystal needs to be diffracted and a protein structure determined to delineate if a fragment binds, the size of our initial screening library cannot be a rate-limiting factor. For this reason, we have chosen 900 as the appropriate primary fragment library size. To choose the best set, we have developed our own mix of simple property ("Rule of 3") and "bad" substructure filtering. While this gets one a long way in terms of limiting the fragment pool, there are still tens of thousands of compounds to choose from after this initial step. Many of the choices left at this stage are not drug-like, so we have developed an FBDD Score to help select a 900-compound set. The details of this score and the filtering are presented. Copyright © 2011 Elsevier Inc. All rights reserved.

Emerging roles for biomedical librarians: a survey of current practice, challenges, and changes.

PubMed

Crum, Janet A; Cooper, I Diane

2013-10-01

This study is intended to (1) identify emerging roles for biomedical librarians and determine how common these roles are in a variety of library settings, (2) identify barriers to taking on new roles, and (3) determine how librarians are developing the capacity to take on new roles. A survey was conducted of librarians in biomedical settings. Most biomedical librarians are taking on new roles. The most common roles selected by survey respondents include analysis and enhancement of user experiences, support for social media, support for systematic reviews, clinical informationist, help for faculty or staff with authorship issues, and implementation of researcher profiling and collaboration tools. Respondents in academic settings are more likely to report new roles than hospital librarians are, but some new roles are common in both settings. Respondents use a variety of methods to free up time for new roles, but predominant methods vary between directors and librarians and between academic and hospital respondents. Lack of time is the biggest barrier that librarians face when trying to adopt new roles. New roles are associated with increased collaboration with individuals and/or groups outside the library. This survey documents the widespread incorporation of new roles in biomedical libraries in the United States, as well as the barriers to adopting these roles and the means by which librarians are making time for them. The results of the survey can be used to inform strategic planning, succession planning, library education, and career development for biomedical librarians.

Effective empirical corrections for basis set superposition error in the def2-SVPD basis: gCP and DFT-C

NASA Astrophysics Data System (ADS)

Witte, Jonathon; Neaton, Jeffrey B.; Head-Gordon, Martin

2017-06-01

With the aim of mitigating the basis set error in density functional theory (DFT) calculations employing local basis sets, we herein develop two empirical corrections for basis set superposition error (BSSE) in the def2-SVPD basis, a basis which—when stripped of BSSE—is capable of providing near-complete-basis DFT results for non-covalent interactions. Specifically, we adapt the existing pairwise geometrical counterpoise (gCP) approach to the def2-SVPD basis, and we develop a beyond-pairwise approach, DFT-C, which we parameterize across a small set of intermolecular interactions. Both gCP and DFT-C are evaluated against the traditional Boys-Bernardi counterpoise correction across a set of 3402 non-covalent binding energies and isomerization energies. We find that the DFT-C method represents a significant improvement over gCP, particularly for non-covalently-interacting molecular clusters. Moreover, DFT-C is transferable among density functionals and can be combined with existing functionals—such as B97M-V—to recover large-basis results at a fraction of the cost.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hart, David; Klise, Katherine A.

The PyEPANET package is a set of commands for the Python programming language that are built to wrap the EPANET toolkit library commands, without requiring the end user to program using the ctypes package. This package does not contain the EPANET code, nor does it implement the functions within the EPANET software, and it requires the separately downloaded or compiled EPANET2 toolkit dynamic library (epanet.dll, libepanent.so, or epanet.dylib) and/or the EPANET-MSX dynamic library in order to function.

Creation of BAC genomic resources for cocoa ( Theobroma cacao L.) for physical mapping of RGA containing BAC clones.

PubMed

Clément, D; Lanaud, C; Sabau, X; Fouet, O; Le Cunff, L; Ruiz, E; Risterucci, A M; Glaszmann, J C; Piffanelli, P

2004-05-01

We have constructed and validated the first cocoa ( Theobroma cacao L.) BAC library, with the aim of developing molecular resources to study the structure and evolution of the genome of this perennial crop. This library contains 36,864 clones with an average insert size of 120 kb, representing approximately ten haploid genome equivalents. It was constructed from the genotype Scavina-6 (Sca-6), a Forastero clone highly resistant to cocoa pathogens and a parent of existing mapping populations. Validation of the BAC library was carried out with a set of 13 genetically-anchored single copy and one duplicated markers. An average of nine BAC clones per probe was identified, giving an initial experimental estimation of the genome coverage represented in the library. Screening of the library with a set of resistance gene analogues (RGAs), previously mapped in cocoa and co-localizing with QTL for resistance to Phytophthora traits, confirmed at the physical level the tight clustering of RGAs in the cocoa genome and provided the first insights into the relationships between genetic and physical distances in the cocoa genome. This library represents an available BAC resource for structural genomic studies or map-based cloning of genes corresponding to important QTLs for agronomic traits such as resistance genes to major cocoa pathogens like Phytophthora spp ( palmivora and megakarya), Crinipellis perniciosa and Moniliophthora roreri.

Uprobe: a genome-wide universal probe resource for comparative physical mapping in vertebrates.

PubMed

Kellner, Wendy A; Sullivan, Robert T; Carlson, Brian H; Thomas, James W

2005-01-01

Interspecies comparisons are important for deciphering the functional content and evolution of genomes. The expansive array of >70 public vertebrate genomic bacterial artificial chromosome (BAC) libraries can provide a means of comparative mapping, sequencing, and functional analysis of targeted chromosomal segments that is independent and complementary to whole-genome sequencing. However, at the present time, no complementary resource exists for the efficient targeted physical mapping of the majority of these BAC libraries. Universal overgo-hybridization probes, designed from regions of sequenced genomes that are highly conserved between species, have been demonstrated to be an effective resource for the isolation of orthologous regions from multiple BAC libraries in parallel. Here we report the application of the universal probe design principal across entire genomes, and the subsequent creation of a complementary probe resource, Uprobe, for screening vertebrate BAC libraries. Uprobe currently consists of whole-genome sets of universal overgo-hybridization probes designed for screening mammalian or avian/reptilian libraries. Retrospective analysis, experimental validation of the probe design process on a panel of representative BAC libraries, and estimates of probe coverage across the genome indicate that the majority of all eutherian and avian/reptilian genes or regions of interest can be isolated using Uprobe. Future implementation of the universal probe design strategy will be used to create an expanded number of whole-genome probe sets that will encompass all vertebrate genomes.

compomics-utilities: an open-source Java library for computational proteomics.

PubMed

Barsnes, Harald; Vaudel, Marc; Colaert, Niklaas; Helsens, Kenny; Sickmann, Albert; Berven, Frode S; Martens, Lennart

2011-03-08

The growing interest in the field of proteomics has increased the demand for software tools and applications that process and analyze the resulting data. And even though the purpose of these tools can vary significantly, they usually share a basic set of features, including the handling of protein and peptide sequences, the visualization of (and interaction with) spectra and chromatograms, and the parsing of results from various proteomics search engines. Developers typically spend considerable time and effort implementing these support structures, which detracts from working on the novel aspects of their tool. In order to simplify the development of proteomics tools, we have implemented an open-source support library for computational proteomics, called compomics-utilities. The library contains a broad set of features required for reading, parsing, and analyzing proteomics data. compomics-utilities is already used by a long list of existing software, ensuring library stability and continued support and development. As a user-friendly, well-documented and open-source library, compomics-utilities greatly simplifies the implementation of the basic features needed in most proteomics tools. Implemented in 100% Java, compomics-utilities is fully portable across platforms and architectures. Our library thus allows the developers to focus on the novel aspects of their tools, rather than on the basic functions, which can contribute substantially to faster development, and better tools for proteomics.

Overview of open resources to support automated structure verification and elucidation

EPA Science Inventory

Cheminformatics methods form an essential basis for providing analytical scientists with access to data, algorithms and workflows. There are an increasing number of free online databases (compound databases, spectral libraries, data repositories) and a rich collection of software...

The patients' library movement: an overview of early efforts in the United States to establish organized libraries for hospital patients.

PubMed Central

Panella, N M

1996-01-01

The patients' library movement in the United States, a dynamic, cohesive drive begun and sustained by librarians and physicians, strove to promote placement of organized libraries for patients in hospitals. It took shape in the early years of this century, evolving from its proponents' deeply held conviction that books and reading foster the rehabilitation of sick people. The American Library Association's World War I service to hospitalized military personnel dramatically reinforced the conviction; the post-World War I institution of public library extension services to general hospitals explicitly reflected it. Enormous energy was infused into the patients' library movement. Throughout the first half of this century, there were sustained efforts not only to establish organized libraries for hospitalized people but also to expand and systematically study bibliotherapy and to shape patients' librarianship as a professional specialty. The movement's achievements include the establishment of patients' library committees within national and international associations; impetus for development of academic programs to train patients' librarians; and publication, from 1944 through 1970, of successive sets of standards for hospital patients' libraries. The first of these remain the first standards written and issued by a professional library association for a hospital library. PMID:8938330

Hospital library service and the changes in national standards.

PubMed Central

Glitz, B; Flack, V; Lovas, I M; Newell, P

1998-01-01

Two important sets of standards affecting hospital libraries were significantly revised in 1994, those of the Medical Library Association (MLA) and the Joint Commission on Accreditation of Healthcare Organizations (JCAHO). As part of its continuing efforts to monitor library services within its region, the University of California, Los Angeles Biomedical Library, Regional Medical Library for the Pacific Southwest Region of the National Network of Libraries of Medicine (NN/LM) conducted a survey in late 1994, in part to determine the effects of these revised standards on regional hospital libraries. Data from the survey were also used to provide a view of hospital libraries in the Pacific Southwest region, and to make comparisons with similar data collected in 1989. Results showed that while libraries remained stable in overall number, size, and staffing, services, especially those associated with end-user searching and interlibrary loan, increased enormously. With respect to the MLA standards, results show a high compliance level. Interesting differences were seen between the perceptions of library staff concerning their rate of compliance with the JCAHO standards and their actual compliance as measured by the MLA criteria. While some libraries appear to measure up better than their own perceptions would indicate, others may be fully aware of their actual compliance level. PMID:9549016

Safeguarding Digital Library Contents: Charging for Online Content.

ERIC Educational Resources Information Center

Herzberg, Amir

1998-01-01

Investigates the need for mechanisms for charging by digital libraries and other providers of online content, in particular for micropayments, i.e., charging for small amounts. The SSL (Secure Socket Layer) and SET (Secure Electronic Transactions) protocols for charge card payments and the MiniPay micropayment mechanism for charging small amounts…

Proposal for Support of Miami Inner City Marine Summer Intern Program, Dade County.

DTIC Science & Technology

1987-12-21

employer NUMBER OF POSITIONS ONE MINIMUM AGE 16 SPECIAL REQUIREMENTS * General Science * Basic knowledge of library orncedures, an interest in library ... science in helpful * Minimum Grade Point Average 3.0 DRESS REQUIREMENTS Discuss with employer JOB DESCRIPTION p. * Catalogs and files new sets of

Perspectives on Library Public Services from Four Leaders

ERIC Educational Resources Information Center

Dallis, Diane

2017-01-01

This article explores and examines the state of library services through interviewing a small group of directors, associate deans, and associate university librarians of public services and identifying common themes and insightful views on this area of librarianship. The participants respond to the same set of questions that cover topics including…

Sandia National Laboratories: CRISPR genome-editing technology

Science.gov Websites

boom sets records, forges ties "Like a jar of jellybeans, a pooled CRISPR library is a complex like individually wrapped and labeled jellybeans. When you identify a particular CRISPR of interest arrayed libraries, the CRISPR of interest is already labeled, therefore hit identification is much easier

The Role of Posters in Teacher Education Programs

ERIC Educational Resources Information Center

Osa, Justina O.; Musser, Linda R.

2004-01-01

Posters abound in education libraries as decorative objects yet few libraries realize the educational potential of the poster. Posters are colorful, attractive learning media which can enhance the learning environment. This paper describes the value of posters in the educational setting, offers suggestions on selecting posters for learning, and…

36 CFR 703.2 - Policy.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Policy. 703.2 Section 703.2 Parks, Forests, and Public Property LIBRARY OF CONGRESS DISCLOSURE OR PRODUCTION OF RECORDS OR INFORMATION Availability of Library of Congress Records § 703.2 Policy. (a) Subject to limitations set out in...

The Black Belt Librarian: Real-World Safety & Security

ERIC Educational Resources Information Center

Graham, Warren

2012-01-01

Sharing expertise gleaned from more than two decades as a library security manager, Graham demonstrates that libraries can maintain their best traditions of openness and public access by creating an unobtrusive yet effective security plan. In straightforward language, the author: (1) Shows how to easily set clear expectations for visitors'…

Retrospective Catalog Conversion in Mid-Sized Law Libraries: Some Practical Guidelines for Automation.

ERIC Educational Resources Information Center

Riger, Robert E.

1992-01-01

Discusses retrospective catalog conversion from the viewpoint of a law firm library. Topics discussed include reasons for retrospective conversion; preplanning; suggestions for the selection of software; conducting an inventory of the collection; sources of MARC bibliographic records; setting up an online public access catalog; and marketing…

The Role of Empathy in Managerial Communication.

ERIC Educational Resources Information Center

Johnson, Peggy

This paper begins with a discussion of the role of communication in the organizational setting in general and in libraries in particular. Four attributes of effective communicators and the responsibility of library managers to foster a communication climate manifesting these attributes are then examined: (1) trust, (2) empathy, (3) openness, and…

Instructional Design: Skills to Benefit the Library Profession

ERIC Educational Resources Information Center

Turner, Jennifer

2016-01-01

Librarians in many types of libraries frequently find themselves positioned as instructors in formal and informal educational settings. Librarians can help ensure that learner needs are better defined and addressed by gaining basic competency in instructional design (ID), an intentional process used to create effective, efficient educational and…